araag2/NLI4PR huggingface dataset:
Clinical trial: Uterine Artery Ligation at Origin in Total Laparscopic Hystrectomy (NCT04808583)

Eligibility criteria:
Inclusion Criteria:

          1. Age group (35-70 years old).

          2. Women consenting to have a total laparoscopic hysterectomy.

        Exclusion Criteria:

          1. Patients with relative contraindication to general anesthesia (e.g. chronic liver cell
             failure)(All laparoscopic procedures are done under GA).

          2. Patients with contraindication to laparoscopic surgery (e.g. severe cardio-pulmonary
             dysfunction).

          3. Bleeding tendency (e.g. anticoagulants, platelets disorders)(will affect the blood
             loss measurement)

          4. Body mass index more than 35 Kg/m2(not suitable for laparoscopic surgeries as obesity
             affects airway pressure )

          5. Uncorrected anemic patients (Hemoglobin < 10 gm. /dl).(will affect the outcomes eg :

        Blood transfusion , hospital stay … etc )
Female
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Longitudinal Imaging in Patients With Large Vessel Vasculitis to Predict Further Disease Course (NCT04204876)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of GCA and having a diagnosis of LV-GCA confirmed by imaging
             (PET/CT)

          -  Informed consent to the local GCA cohort BARK

          -  Followed for GCA treatment in the outpatient department.

        Exclusion Criteria:

          -  Known hypersensitivity or allergy to Gadolinium (Gd)-based MRI contrast agents.

          -  Patients with cardiac pacemakers, intra cranial clips, metallic foreign bodies or
             other not MR-compatible implants (e.g. pumps etc.).

          -  Renal failure or severely impaired kidney function (eGFR < 30 ml/min /1,73 m2)

          -  Epilepsy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Contradiction
Clinical trial: Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: A Pilot Study (NCT00035386)

Eligibility criteria:
INCLUSION CRITERIA:

        Patients of either gender, aged 18-85 years.

        Symptomatic patients receiving clinically indicated evaluation for cardiomyopathy and found
        to have obstructive HCM.

        LV outflow tract gradient greater than 30 mm Hg at rest by echocardiography or cardiac
        catheterization.

        EXCLUSION CRITERIA:

        Positive pregnancy test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: Trial for the Diagnosis of Sarcoidosis (NCT00872612)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with suspected pulmonary sarcoidosis stage I/ II

          -  Age > 18 years

          -  Both males and females

          -  Written informed consent is obtained.

        Exclusion Criteria:

          -  Patients with obvious other organ involvement of sarcoidosis where a simple diagnostic
             biopsy to assess granulomas can be performed.

          -  Löfgren's syndrome

          -  Inability to undergo fiberbronchoscopy, EBUS or EUS (e.g. respiratory insufficiency,
             esophageal stenosis

          -  Contraindications for a lung or nodal biopsy (e.g. coagulopathy, thrombocytopenia)

          -  Pregnancy

          -  Inability to obtain informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? Contradiction
Clinical trial: ED Overcrowding Validation Study (NCT02754245)

Eligibility criteria:
Inclusion Criteria:

          -  all adult patients visiting the emergency department or urgent care clinic at any one
             of the six participating sites during the allocated one month time period

        Exclusion Criteria:

          -  those who do not meet inclusion criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Entailment
Clinical trial: Intervention Study of Drugs in Patients Osteopenia and Osteoporosis (NCT04719572)

Eligibility criteria:
Inclusion Criteria:

          -  Informed consent obtained before any trial-related activities

          -  Postmenopausal women and male aged 50 years or old

          -  Osteoporosis by DXA or fragility fracture history

          -  Osteopenia with more than one osteoporotic risk factors

        Exclusion Criteria:

          -  Secondary osteoporosis

          -  Renal insufficiency (Ccr< 35ml/min)

          -  New fractures < 3 months, prior bilateral hip fractures or surgical replacement.

          -  Other medication contraindications

          -  Malignant tumors

          -  Mobility-impaired individuals
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: The Clinical and Biological Effects Of The Use Of Probiotic VSL#3 In Patients With Oral Lichen Planus (NCT03052179)

Eligibility criteria:
Inclusion Criteria:

          1. Biopsy-proven diagnosis of OLP as per WHO histological criteria* with no evidence of
             epithelial dysplasia or malignancy.

          2. Presence of painful oral symptoms associated to OLP, with minimum severity of pain
             being 3 or more, on a 0-10 numeric pain rating scale at screening and confirmed at
             recruitment/start of the intervention.

          3. Age >18 years and willing to participate into the study.

          4. Receiving no therapy or receiving best standard topical therapy (typically topical
             corticosteroids or immunosuppressant) with the exclusion of systemic corticosteroids
             or systemic immunosuppressant

        Exclusion Criteria:

          1. Use of systemic antibiotics, retinoid, corticosteroids or immunosuppressant.

          2. Pregnancy or receiving IVF treatment.

          3. Individuals with systemic disorders affecting the immune system (e.g., HIV, connective
             tissue disorders, cancer, etc.)

          4. Evidence of oral dysplasia or malignancy on previous biopsy. -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Relation Between Blood Concentration of Colchicine and Response to Colchicine Treatment in Gout Flare (NCT03933007)

Eligibility criteria:
Inclusion Criteria:

        Patients (> 18 years old) with gout flare defined by following items :

          -  Identification of sodium urate crystals in synovial fluid analysis

          -  Or gout flare diagnosis according to Nijmegen criteria (score > 8/13)

               -  Man (2 pts)

               -  History of flare (2 pts)

               -  Flare involving first metatarsophalangeal joint (2.5 pts)

               -  Maximum of flare within 24h (0.5pt),

               -  Redness (1 pt),

               -  History of hypertension or cardiovascular diseases (1.5 pts),

               -  Serum urate level > 360 µmol/l during flare (3.5 pts)

          -  Duration of flare < 48 h

          -  Monoarticular involvement

        Exclusion Criteria:

          -  Hypersensitivity to colchicine, fexofenadine, benzodiazepine or the excipients of
             these drugs

          -  Contra-indication to colchicine : chronic kidney disease stage 4-5, severe hepatic
             impairment, treatment by macrolide antibiotics

          -  Used of pain-killers other than acetaminophen

          -  Involvement in another clinical trial with drug administration

          -  Illiteracy

          -  Pregnant woman or breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Entailment
Clinical trial: Microbiome Analysis in Gastric Intestinal Metaplasia and in Gastric Cancer and Subtypes Correlation (NCT04365946)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with gastric intestinal metaplasia and/or gastric cancer

          -  Healthy controls

        Exclusion Criteria:

          -  Metabolic syndrome and its components

          -  IBD

          -  Autoimmune diseases

          -  Otherwise tumours
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Achondroplasia Natural History Multicenter Clinical Study (NCT02597881)

Eligibility criteria:
Inclusion Criteria:

          -  Molecular or clinical diagnosis of achondroplasia (as confirmed by physical exam
             and/or radiograph review by the PI, one of the co-PIs or other qualified clinical
             geneticists)

          -  Subjects must have been seen for a clinical genetics visit at Johns Hopkins, Alfred I.
             DuPont Hospital for Children, University of Wisconsin-Madison or University of Texas

          -  Subjects may be active clinical patients at the above sites or no longer treated at a
             given site but with sufficient retrospective clinical data for extraction as
             determined by the PI or co-PIs

        Exclusion Criteria:

          -  Skeletal dysplasia diagnosis other than heterozygous

          -  Achondroplasia

          -  There is no medical complication or condition which excludes a patient with
             achondroplasia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Entailment