araag2/NLI4PR huggingface dataset:
Clinical trial: Biomarkers in Primary Sjögren's Syndrome (NCT03765593)

Eligibility criteria:
Inclusion Criteria:

          -  Patients: cross sectionally patients will be included for clinical suspicion of
             primary SS or with the diagnosis already established in Rheumatology unit.

        The following inclusion criteria will be applied to the study:

          -  Age > 18 years

          -  Informed consent of the patient.

        Exclusion Criteria:

          -  Impossibility of obtaining consent (cognitive impairment, other causes).

          -  Associated systemic autoimmune or rheumatological diseases.

          -  Chronic viral infections (HCV, HBV, HIV).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Tongue Strengthening for Swallowing Problems (NCT01570023)

Eligibility criteria:
Inclusion Criteria:

          -  referral by a physician for swallowing evaluation because of suspected dysphagia

          -  complaint of difficulty swallowing

          -  aspiration or penetration of the laryngeal vestibule with liquids or semisolids OR
             post-swallow residue visible in the oral cavity, valleculae, or pharynx that is
             instrumentally documented by a participating SLP during a standard clinical
             videofluoroscopic swallowing study

          -  between the ages of 21 and 95

          -  ability to perform the exercise protocol independently or with the assistance of a
             caregiver

          -  physician approval of medical stability to participate

          -  decision-making capacity to provide informed consent (confirmed through discussion
             between the participating SLP and the subject's primary physician)

        Exclusion Criteria:

          -  degenerative neuromuscular disease

          -  poorly controlled psychosis

          -  patient unable to complete the exercise program

          -  allergy to barium (used in videofluoroscopic swallowing assessment)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 95 Years

Patient description (medical language): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient description (patient's own words): I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Does the patient match the trial criteria? Entailment
Clinical trial: Inflammatory Mediators in Erythema Migrans (NCT03956212)

Eligibility criteria:
Inclusion Criteria:

          -  erythema migrans in patients > 18 years

        Exclusion Criteria:

          -  pregnancy or immunocompromising conditions

          -  taking antibiotic with antiborrelial activity within 10 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? Entailment
Clinical trial: Educational Impact of the NLM/National Area Health Education Center Organization (NAO) Project-SHARE Based Teen Health Information Literacy Curriculum (NCT02769988)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Participation in the NLM / NAO Teen Health Information Literacy Project

        EXCLUSION CRITERIA:

        -NA
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluating the Potential of the Diet as Disease Modifier in Amyotrophic Lateral Sclerosis (JERN_ALS) (NCT02572479)

Eligibility criteria:
Inclusion Criteria:

          -  ALS patients diagnosed according to El Escorial / Awaji criteria for ALS

          -  patients should have the ability to comprehend the full nature and purpose of the
             study, to cooperate with the investigator, to understand verbal and written
             instructions, and to comply with the requirements of the entire study.

        Exclusion Criteria:

          -  patient's request or if patient compliance with the study protocol is doubtful
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of Varied Estrogen Doses on Endometrial Receptivity (NCT02458404)

Eligibility criteria:
Inclusion Criteria:

          -  Regular menstrual cycles

          -  Age 18-50

          -  Normal Baseline ultrasound

          -  No intra-uterine procedures in prior 90 days

        Exclusion Criteria:

          -  Any contraindications to undergoing estrogen stimulation of the endometrium

          -  Age ≥35 years and smoking ≥15 cigarettes per day

          -  Multiple risk factors for arterial cardiovascular disease (smoking, diabetes, and
             hypertension)

          -  Hypertension (systolic ≥140 mmHg or diastolic ≥90 mmHg)

          -  Venous thromboembolism (current or history of)

          -  Known thrombogenic mutations

          -  Known ischemic heart disease

          -  History of stroke

          -  Complicated valvular heart disease (pulmonary hypertension, risk for atrial
             fibrillation, history of subacute bacterial endocarditis)

          -  Systemic lupus erythematosus (positive or unknown antiphospholipid antibodies)

          -  Migraine with aura at any age

          -  Breast cancer

          -  Cirrhosis

          -  Hepatocellular adenoma or malignant hepatoma

          -  History of undiagnosed abnormal uterine bleeding.

          -  Allergic reaction to any study drug

          -  Known pregnancy or delivery within the past 6 months

          -  Breastfeeding

          -  Obesity >35 kg/m2
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Mysterious on/Off Itch and Erythema During Whole Body Vibration Exercise (NCT03455036)

Eligibility criteria:
Inclusion Criteria:

          -  age 18-35 years

          -  female

          -  Informed Consent as documented by signature (Appendix Informed Consent Form)

        Exclusion Criteria:

          -  itchy skin diseases

          -  hay fever

          -  asthma

          -  chronic venous insufficiency

          -  peripheral artery disease

          -  musculoskeletal diseases or injuries affecting the legs, hips and pelvis

          -  BMI < 17 and > 35 kg/m2

          -  pregnancy
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? Contradiction
Clinical trial: Retro-walking in Knee Osteoarthritis (NCT04546659)

Eligibility criteria:
Inclusion Criteria:

          -  Patient suffering with Osteoarthritis knee for three months at least

          -  Age ranges from 40-70

          -  knee OA as per the American College of Rheumatology clinical and radiographic
             diagnostic criteria will participate

          -  1-3 radiographic grades on the Kellgren-Lawrence scale

          -  Both genders will be included

          -  being able to cooperate

          -  Bilateral knee osteoarthritis

        Exclusion Criteria:

          -  Traumatic knee pain, fractures or ruptured ligaments, meniscopathy of knee joint

          -  Inflammatory and Infectious knee conditions (RA, gout, psoriatic arthritis)

          -  Balance problem

          -  Any recent surgical intervention of knee joint or those who had undergone arthroplasty

          -  Surgeries in hip or knee

          -  Tumors/malignancy of bone
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Assistive Device for Hand Osteoarthritis (NCT02667145)

Eligibility criteria:
Inclusion Criteria:

          -  Hand OA diagnosis according to the criteria of the American College of Rheumatology
             (ACR )

          -  Be properly registered in the rheumatology clinic of Hospital das Clínicas

        Exclusion Criteria:

          -  Surgical treatment or infiltration in the hands, in the last 6 months;

          -  Treatment of occupational therapy and / or physical therapy, or use of any TA feature
             (assist device or stent) in the last 6 months;

          -  Diagnosis of another rheumatologic disease or musculoskeletal system that compromise
             the hands associated.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Normal and Small Size Mesh in Open Inguinal Herni Repair (NCT04269330)

Eligibility criteria:
Inclusion Criteria:

          -  ages must be upper 18

        Exclusion Criteria:

          -  Morbit obesity (BMI>40)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment