Clinical trial: Test-retest Reproducibility of [11C]PHNO PET Using the Constant Infusion Paradigm (NCT01699607)

Eligibility criteria:
Inclusion Criteria:

          -  men and women, aged 18-55 years

          -  who are able to read and write

          -  who are able to give voluntary written informed consent

          -  have no current uncontrolled medical condition such as neurological, cardiovascular,
             endocrine, renal, liver, or thyroid pathology

          -  have no history of a neurological or psychiatric disorder, e.g., no DSMIV Axis 1
             diagnosis in 2 preceding years, except nicotine dependence in smokers)

          -  drink less than 21 drinks/week for women and less than 35 drinks per week for men

          -  have not used marijuana in the past 30 days and have not met criteria for dependence
             in the past 2 years

          -  do not suffer from claustrophobia or any MRI contradictions

          -  nonsmokers (smoked < 40 cigarettes in lifetime with urinary cotinine levels 0-30 ng/mL
             both at intake evaluation and on scan day)

          -  smokers (smoked at least 10 cigarettes/day for at least one year with an FTND>3, urine
             cotinine >150 ng/mL and CO >12 ppm at intake)

        Exclusion Criteria:

          -  psychosis

          -  presence of acute or unstable medical or neurological illness. Subjects will be
             excluded from the study if they present with any history of serious medical or
             neurological illness or if they show signs of a major medical or neurological illness
             on examination or lab testing including history of seizures, head injury, brain tumor,
             heart, liver or kidney disease, eating disorder, diabetes.

          -  regular use of any psychotropic drugs including anxiolytics and antidepressants and
             other over-the-counter medications and herbal products within the last six months

          -  pregnancy/breast feeding (as documented by pregnancy testing at screening or on days
             of the imaging studies),

          -  suicidal ideation or behavior

          -  pacemaker or other ferromagnetic material in body.

          -  use of medications which affect dopamine transmission within 2 weeks of the PET study

          -  participation in other research studies involving ionizing radiation within one year
             of the PET scans that would cause the subject to exceed the yearly dose limits for
             normal volunteers
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment