araag2/NLI4PR huggingface dataset:
Clinical trial: Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma (NCT02613299)

Eligibility criteria:
Inclusion Criteria:

          -  Subject provides informed consent

          -  Subject is >18 years of age

          -  Subject is deemed competent for making medical decisions

          -  Subject is scheduled to undergo radiation followed by extrapleural pneumonectomy.

          -  Subject is a surgical candidate

          -  A negative pregnancy test is required in women of child-bearing potential, as standard
             of care.

        Exclusion Criteria:

          -  Subject is <18 years old.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study of Efficacy and Safety With the Transdermal Contraceptive System Versus Triphasil. (NCT00236795)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy, nonpregnant women with regular menstrual cycles

          -  sexually active and at risk of pregnancy

          -  acceptable body mass index (BMI)

          -  last term pregnancy at least 42 days prior, nonlactating, with 1 normal menstrual
             cycle since

          -  sitting BP<140mmHg/<90mmHg

          -  1 normal menstrual cycle since removal of IUD or norplant

          -  agreement to use study drug for contraception for up to 13 cycles, except when backup
             contraception is required for disease protection or patch detachment

          -  agree not to use other systemic steroid medication

        Exclusion Criteria:

          -  Presence, history, hereditary predisposition or risk of deep vein thrombophlebitis or
             thromboembolic disorders

          -  cerebral vascular or coronary artery disease, hypertension, or severe migraines

          -  liver tumor resulting from estrogen-containing products

          -  diabetes mellitus

          -  cholestatic jaundice, liver or renal disease

          -  abnormal PAP smear

          -  undiagnosed abnormal vaginal bleeding

          -  thyroid disorder

          -  dermal hypersensitivity

          -  carcinoma of breast, genital tract or other estrogen-dependent neoplasia

          -  received any depot hormone injection within prior 6 months

          -  smoking women over 35 years of age.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Immediate Effect Of Whole-Body Vibration And Walk in Osteoporosis/Osteopenia (NCT03448276)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of osteoporosis or osteopenia examination of bone densitometry;

          -  Patients without severe neurological disease, vascular disorders, labyrinthitis and
             blindness;

          -  No use of gait auxiliaries;

          -  No history of fractures of the lower limbs in the last year;

          -  Do not be an alcoholic inactive (0 to 5 points) or less active (6 to 11 points)
             accordance with the usual physical activity questionnaire (QAFH).

        Exclusion Criteria:

        -Patients who submit to hypertensive peak, nausea and dizziness during the training
        program.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: An Open Label Trial for Treating Carpometacarpal Osteoarthritis of the Thumb: Pilot Study (NCT00198029)

Eligibility criteria:
Inclusion Criteria:

          -  Radiographic evidence of at least moderate narrowing (joint space < 1mm) or the
             presence of osteophytes or sclerosis at the Carpometacarpal joint

          -  Patient complaint of unacceptable pain despite modification of activity, a trial of
             splinting and a therapeutic dose of NSAIDS

          -  If bilateral disease, only the most severely involved hand, (as defined by VAS for
             pain), will be entered in the study.

          -  Proficiency in English.

        Exclusion Criteria:

          -  Previous bad injury to the thumb

          -  Previous hand surgery on the study thumb

          -  Known hand comorbidities (i.e. carpal tunnel syndrome, de Quervains Tenosynovitis etc)

          -  Rheumatoid arthritis or lupus

          -  Bleeding problems

          -  Being on blood thinners (except aspirin)

          -  Known allergies to any of the medications being used

          -  Allergies to chicken products

          -  Current use of oral steroids

          -  Cancer that is not cured or in remission

          -  Severe diabetes

          -  A serious infection somewhere else in the subject's body
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 95 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction
Clinical trial: Studying Skeletal Muscle, Heart, and Diaphragm Imaging in Boys With Duchenne Muscular Dystrophy (NCT01451281)

Eligibility criteria:
-  INCLUSION CRITERIA:

        DMD Subjects

          -  Eligible for the parent study

          -  Willing and able to comply with all protocol requirements and procedures, including
             MRI without sedation

          -  Able to give informed assent and parent(s)/legal guardian to give informed consent in
             writing signed by the subject and/or parent(s)/legal guardian

        Healthy Volunteers

          -  Must be unaffected by a neuromuscular condition

          -  Willing and able to comply with all protocol requirements and procedures, including
             MRI without sedation.

          -  Able to give informed assent and parent(s)/legal guardian to give informed consent in
             writing signed by the subject and/or parent(s)/legal guardian.

        EXCLUSION CRITERIA:

        DMD Subjects and Healthy Volunteers

          -  Having metal objects in his body that are not MRI-safe. These include the following
             objects: 1) pacemakers or other implanted electrical devices; 2) brain stimulators; 3)
             some types of dental implants; 4) aneurysm clips (metal clips on the wall of a large
             artery); 5) metallic prostheses (including metal pins and rods, heart valves, and
             cochlear implants; 6) implanted delivery pump; 7) permanent eye liner; or 8) shrapnel
             fragments.

          -  Having a fear of closed spaces
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 17 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Height Loss, Kyphosis Indicators, Bone Mineral Density and Vertebral Fractures in Chinese Postmenopausal Women (NCT03798444)

Eligibility criteria:
Inclusion Criteria:

        Postmenopausal women aged ≥50 years (Menopause was defined as the absence of menstrual
        cycles for at least one year)

        Exclusion Criteria:

        Morphological abnormalities or skeletal distortions
Female
Accepts Healthy Volunteers
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of Functional Activities and Balance Ability With Taping in Subjects of Hemophilia (NCT02389205)

Eligibility criteria:
Inclusion Criteria:

          -  subject of Hemophilia

          -  20-65 years old

        Exclusion Criteria:

          -  Any history of surgery
Male
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Renin-Angiotensin-Aldosterone System Inhibitors, Hypertension, and COVID-19 (NCT04374695)

Eligibility criteria:
Inclusion Criteria:

          -  Age equal or more than 18;

          -  Symptoms suggestive of Covid-19 pneumonia. At least : fever > 38°C or influenza-like
             illness (asthenia, myalgia, chills, muscular aches, …) AND cough or dyspnea;

          -  Hospitalization required on clinical criteria including: oxygen saturation <96%
             without oxygen support, respiratory frequency > 25 per minute, hemodynamic
             instability, medical history or comorbidities known at high risk for Covid-19 (chronic
             heart disease, congestive heart failure, chronic bronchopulmonary disease, diabetes
             mellitus, age>70, history of cancer, immunosuppression, …);

          -  Covid-19 confirmation test performed (RT-PCR).

        Exclusion Criteria:

          -  Age < 18

          -  Refusal to participate in the study

          -  detainee or prisoner

          -  Protected adult uncapable to consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Powered Exoskeleton for Veterans With Knee OA (NCT04653896)

Eligibility criteria:
Inclusion Criteria:

          -  medical diagnosis of Grade 3 or 4 knee OA

          -  have a prescribed knee brace for at least three months

          -  self-reported knee pain when standing, walking, climbing stairs, squatting, or other
             mobility activities

          -  self-reported limitations to mobility and walking activities due to knee pain,
             stiffness, loss of range of motion

        Exclusion Criteria:

          -  neurological paralysis causing an inability to stand, weight bear or take stepping
             movements

          -  fixed contractures resulting in limited range of motion in the hip, knees, or ankles
             that prevent sitting, standing, walking, and/or squatting activities

          -  able to walk at a normal walking speed (>1.2 m/s) based on a 6-minute walk test (6MWT)

          -  anthropometric incompatibility with the device

          -  any medical complication or co-morbidity as judged by the study physician to be
             contraindicated for wearing the device or walking (e.g., cardiovascular disorders,
             pressure ulcers, open wounds, lower limb vascular disorders, or other medical
             conditions)

          -  a score of <8/10 on the MacArthur Competence Assessment Tool for Treatment (MacCAT-T)
             (as a proxy for cognitive competency screening); and 7) pregnancy or planning on
             becoming pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment