araag2/NLI4PR huggingface dataset:
Clinical trial: Clinical Testing of New MR Pulse Sequences (NCT00590252)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy volunteers

          -  Patients undergoing clinical indicated MRI

        Exclusion Criteria:

          -  Patients with contraindication for MRI

          -  Pregnant women will be excluded from this study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: 2-cohort Study of Adult Patients With Severe Hemophilia A in Greece (NCT02319070)

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with severe Hemophilia A.

          -  Age ≥18 years old

          -  Patients able to read and write

          -  Patients receiving Factor VIII substitute therapy, either on-demand or as secondary
             prophylaxis.

          -  Patients under the same therapeutic strategy (On Demand or Secondary Prophylaxis) for
             at least 6 months prior to enrolment.

        Exclusion Criteria:

          -  Patients that have developed inhibitors against factor VIII.

          -  Patients participating in an investigational program with interventions outside of
             routine clinical practice.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Treatment Patterns And Outcomes In Patients Treated With Benefix Or Refacto/Refacto AF - A Swedish Cohort Study (NCT02740413)

Eligibility criteria:
Inclusion Criteria:

          -  The study population will consist of all patients diagnosed with hemophilia (D66.9
             (hemophilia A) D67.9 (hemophilia B) in International Statistical Classification of
             Diseases and Related Health Problems (ICD-10) that have been registered in the Malmö
             Hemophilia Register since 1977 and that have had at least one registered prescription
             of BeneFIX or ReFacto/ReFacto AF in the MHR since market authorization of the
             respective product

        Exclusion Criteria:

          -  No exclusion criteria in this study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Four-Week Multicenter Study Evaluating the Safety and Efficacy of Gefapixant (AF-219/MK-7264) in Subjects With Osteoarthritis of the Knee (NCT01554579)

Eligibility criteria:
Inclusion Criteria:

          -  Men or women

          -  Women of child bearing potential must not be pregnant during the study and must use
             two forms of birth control

          -  Men and their female partners must use two forms of birth control

          -  Clinical and radiographic evidence of chronic knee osteoarthritis

          -  An average NPRS score of >=5 and <=9 over a 4-7 day washout period of their previous
             osteoarthritis medications

          -  Ambulatory

          -  Have provided written informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Oral Ulcer Prevalence: Hospital-based Cross-sectional Study (NCT03167632)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects whose age was above 15 years old.

        Exclusion Criteria:

          -  Subjects having problem in opening their mouth (due to non-oral ulcer cause) or
             undergoing intermaxillary fixation where oral examination was not possible.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Entailment
Clinical trial: Clinical Management of Hereditary Hemochromatosis: Phlebotomy vs. Erythrocytoapheresis (NCT00440986)

Eligibility criteria:
Inclusion Criteria:

          -  Patiens newly diagnosed having Hereditary Hemochromatosis

        Exclusion Criteria:

          -  Age < 18 yrs.

          -  Not obese (BMI <30)

          -  Not consuming alchol beverages,

          -  Not affected by systemic diseases and known hepatic viruses
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment
Clinical trial: A Prospective, Observational Study of the PPI Non-responder (NCT03282084)

Eligibility criteria:
Inclusion Criteria:

          -  Willing and able to sign informed consent

          -  Persistent GERD symptoms after minimum 8 week trial on daily PPI

        Exclusion Criteria:

          -  Unwilling to sign informed consent

          -  Prior anti-reflux surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Using PET-CT to Target and Validate Low-frequency TMS as Treatment for Tinnitus (NCT00329524)

Eligibility criteria:
Inclusion Criteria:

          -  right-handed subjects

          -  19-65 years of age

          -  debilitating unilaterial or bilateral tinnitus

          -  Experiencing the presence of phantom auditory preception for >6 months

          -  Tinnitus Handicap Questionnaire score of >30

        Exclusion Criteria:

          -  significant neurological disease

          -  acoustic neuromas or glomus tumors

          -  active Meniere's disease

          -  profound hearing loss

          -  non English speaking

          -  personal or family history of epilepsy

          -  personal history of head injury, aneurysm, stroke, previous cranial neurosurgery,
             neurological or psychiatric disorders, metal implants in the head or neck, a
             pacemaker, pregnancy, migraines,

          -  medications that lower seizure threshold and are contraindicated

          -  individuals who have been taking certain medications

          -  claustrophobia

          -  patients who do not exhibit significant cortical asymmetries on PET
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Contradiction
Clinical trial: Three-times-weekly Versus Daily Growth Hormone (GH) Treatment in naïve GH-deficient Children (NCT03033121)

Eligibility criteria:
Inclusion Criteria:

          -  Growth hormone deficiency clinically and biochemically demonstrated

        Exclusion Criteria:

          -  Children affected by multiple pituitary hormone deficiency or receiving any other kind
             of hormonal replacement therapy or drug and GHD children with a shorter follow-up
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Association Between Individual Clotting Factor Level Monitoring and the Risk of Bleeding Whilst Physical Active Conditions (NCT04845555)

Eligibility criteria:
Inclusion Criteria:

          -  patients suffering from moderate or severe hemophilia A (FVIII <5%, ≥ 12 years old)

          -  factor treatment with ADVATE© or ADYNOVI©

          -  use of myPKFiT

        Exclusion Criteria:

          -  patients suffering from other coagulopathies

          -  participants without written consent

          -  participants < 12 years old

          -  joint surgery like arthroscopy, synovectomy up to six months before study

          -  suffering from different rheumatologic diseases like M. Bechterew, Psoriasi or other
             local or generalized joint infections (Borreliosis, septic arthritis)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Comparison of Factors of Symptoms Generation and Evaluation of Role of Biofeedback in Patients With Different Types of Functional Esophageal Disorders (Functional Heartburn and Functional Chest Pain) (NCT00471796)

Eligibility criteria:
Inclusion Criteria:

          1. Men and women ages 18-75.

          2. Willing to participate and sign an inform consent.

          3. Having heartburns, acid regurgitations and/or chest pain at least twice a week for at
             least 3 months.

          4. Ability to stop anti-acid and anti-pain medications for at least two weeks.

        Exclusion Criteria:

          1. History of upper gastrointestinal surgery.

          2. Concomitant diseases that may affect esophageal perception (diabetes mellitus,
             neuropathy).

          3. Concomitant medications that may affect esophageal perception (anti-inflammatory,
             anti-depressants drugs).

          4. Pregnancy.

          5. Severe conditions such as cardiac failure, renal failure and other that may be
             contraindication for upper endoscopy.

          6. Erosive esophagitis on upper endoscopy or pathological result of ambulatory 24-hour pH
             monitoring.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Percutaneous Vertebroplasty Versus Conservative Treatment of Pain (NCT00203554)

Eligibility criteria:
Inclusion Criteria:

          -  new pain in spine (within 6 months)

          -  x-ray verified low energy spinal fracture(s)

        Exclusion Criteria:

          -  less than 20% or more than 90% reduction of the vertebral height

          -  lack of pain at fracture level

          -  no need for continuous analgesic treatment

          -  patient no able to communicate

          -  general anaesthesia contraindicated

          -  MRI not possible

          -  coagulopathy (not adjustable)

          -  spondylitis

          -  discitis

          -  spinal metastasis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment