araag2/NLI4PR huggingface dataset:
Clinical trial: Studies of Children With Metabolic and Other Genetic Disorders (NCT00025870)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Patients with suspected or diagnosed genetic and/or metabolic conditions of all ages
             are eligible for this protocol.

          -  In addition, children with unexplained developmental delay, deafness, dysmorphism,
             congenital malformations, acidosis, failure to thrive, feeding problems, short
             stature, birth defects, and other syndromes of sporadic or unknown etiology will
             qualify for this protocol.

          -  The actual selection of patients most appropriate for research and clinical training
             needs will be made by protocol investigators.

        EXCLUSION CRITERIA:

          -  Patients that their care requires resources not available at the NIH Clinical Center
             will not be eligible for the in-patient part of this study.

          -  There are no exclusions for the out-patient or DNA collection part of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Menstrual Cycle Characteristics of Healthcare Professionals (NCT04413058)

Eligibility criteria:
Inclusion Criteria:

          -  Working at Covid 19 Pandemic Hospital

          -  Being at between 18 and 47 years old

          -  Having menstruation

        Exclusion Criteria:

          -  Oral contraceptive users

          -  Pregnants

          -  Having malignancy

          -  Having primary amenorrhea

          -  Being at menopause

          -  Lactation
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 47 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Clinical Evaluator Outcomes Reliability Study (NCT02146586)

Eligibility criteria:
Dystrophinopathy Participant Inclusion Criteria:

          -  Site confirmed genetic diagnosis of a dystrophinopathy

          -  Aged 6 years and older

          -  Able to transfer to testing table

          -  Able to walk 10 meters without an assistive device

        Dystrophinopathy Participant Exclusion Criteria:

          -  Investigator assessment of inability to comply with protocol assessments

          -  Participants who have attention deficient disorder or other cognitive conditions that
             may limit attention span to perform protocol assessments
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of Postoperative Pain After Gallbladder Retrieval From Umbilical and Epigastric Ports. (NCT04208568)

Eligibility criteria:
Inclusion Criteria:

          -  All healthy patients without cholecystitis

        Exclusion Criteria:

          -  Acute cholecystits, mucocoele, empyema, carcinoma, peritonitis, ASA 3 and 4
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Effect and Essentiality of Vertebroplasty Surgery in Acute Vertebral Compression Fractures (NCT03360383)

Eligibility criteria:
Inclusion Criteria:

          -  vertebral compression fracture on spine radiograph (minimum 15% height loss)

          -  level of fracture at Th5 or lower; back pain for 6 weeks or less

          -  focal tenderness at fracture level on physical examination

          -  bone oedema of vertebral fracture on MRI

          -  decreased bone density (T scores ≤-1)

        Exclusion Criteria:

          -  severe cardiopulmonary comorbidity

          -  suspected underlying malignant disease

          -  radicular syndrome

          -  spinal-cord compression syndrome

          -  contraindication for radiography exam
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Development of a Nutrigenetic Test for Personalized Prescription of Body Weight Loss Diets (Obekit) (NCT02737267)

Eligibility criteria:
Inclusion Criteria:

          -  Body Mass Index (BMI) between 25 and 40 kg/m2

          -  Physical examination and vital signs normal, or is considered abnormal, but clinically
             insignificant by researcher.

          -  In the case of individuals with chronic stable dose drug treatment and during the last
             3 previous months at baseline, the investigator will assess their possible inclusion.

        Exclusion Criteria:

          -  BMI less than 25 or higher than 40 kg/m2

          -  Pregnant women

          -  Breastfeeding period. If artificial feeding until 6 months after birth.

          -  Type 1 diabetes

          -  Severe kidney diseases

          -  Severe digestive system diseases

          -  Electrolyte disorders (disorders of sodium, potassium, calcium, chlorine, phosphorus,
             magnesium)

          -  Acute cardiovascular diseases

          -  Cancer

          -  Anemia

          -  Eating disorders

          -  Recent prescription drug treatment (without stable doses scheduled)

          -  Drug therapy that can influence weight loss as corticosteroids.

          -  Some type of cognitive impairment and / psychic

          -  Subjects in which poor collaboration or, in the investigator's opinion, have
             difficulty following the procedures of the study is foreseen

          -  Lack of commitment (at the discretion of the investigator) with the intervention,
             suspected non-compliance, or real difficulties to follow the development of the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Cementation Techniques for Single-tooth Implant Crowns (NCT03581565)

Eligibility criteria:
Inclusion Criteria:

          -  completed growth and development

          -  periodontally and dentally healthy conditions

          -  missing single molar tooth without free-end edentulism

          -  bone-level standard diameter of a specific implant from one manufacturer

          -  complication free healing period for osseointegration following straightforward
             surgical implant placement

          -  natural dentition or fixed restoration in dental arch

          -  signing of informed consent form

        Exclusion Criteria:

          -  absolute systemic contraindications for implant surgery (e.g. bone cancer, radiation
             therapy)

          -  relative systemic contraindications for implant surgery (e.g. diabetes, steroid
             therapy)

          -  risk factors (e.g. smoking, limited mouth opening)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of Endometrial Stromal Cell Apoptosis in Adenomyosis (NCT00172588)

Eligibility criteria:
Inclusion Criteria:

          -  women with adenomyosis

          -  at early- to mid-secretory phases

        Exclusion Criteria:

          -  postmenopausal

          -  malignancy
Female
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Dietary Fiber on Metabolism, Inflammation and Nutritional Status in Patients With Chronic Diseases (NCT04690075)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-70y

          -  Be diagnosed with obesity, hyperlipemia or hyperglycemia

          -  Fully understood and voluntarily signed the informed consent

        Exclusion Criteria:

          -  Secondary hyperlipidemia or hyperglycemia

          -  Multiple organ failure

          -  Allergic or intolerant to dietary fiber(dietary supplement)

          -  Have gastrointestinal diseases

          -  Have a history of abdominal diseases

          -  Experienced intra-abdominal surgery

          -  Pregnant and lactating women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of Testosterone Replacement in Patients With Hypogonadotrophic Hypogonadism Due to Opioid Treatment for Non-malignant Disease (NCT02433730)

Eligibility criteria:
Inclusion Criteria:

          -  Male patients 18-75 years

          -  Treatment with opioid for >3 months, daily dose >50-100 mg

          -  Total testosterone < 12 mmol/L

          -  Follicle Stimulating Hormone (FSH)/Luteinizing Hormone (LH) levels normal og below
             normal laboratory values

          -  Normal prolactin levels

        Exclusion Criteria:

          -  Hematocrit> 54% at screening

          -  Prostate Specific Antigen (PSA) > 3 ng/ml

          -  Severe organic and mental disease

          -  current or present cancer diagnosis

          -  Previous venous thrombotic embolism and cerebrovascular disease

          -  Uncontrolled hypertension

          -  Epilepsy or migraine not adequately controlled by therapy

          -  Severe benign prostate hypertrophy with symptom score >19

          -  Sleep apnea

          -  Alcohol or drug abuse

          -  Implantation of sustained action sex hormone in the last 12 months

          -  Use of oral, buccal or transdermal testosterone in the last two weeks

          -  Treatment with glucocorticoids > 5 mg/day or 5 alfa reductase inhibitors

          -  Hypersensitivity to Nebido
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Human Movement Database (NCT00001252)

Eligibility criteria:
-  Any volunteer of any age from birth to old age who is deemed medically fit to
             participate and is willing to provide their informed consent will be included in the
             study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 1 Month old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment