araag2/NLI4PR huggingface dataset:
Clinical trial: Intrapleural Fibrinolytic Therapy to Enhance Chemical Pleurodesis Enhance Chemical Pleurodesis (NCT04806373)

Eligibility criteria:
Inclusion Criteria:

          1. Age > 18 years

          2. Symptomatic pleural effusion requiring intervention

          3. Expected survival > 3 months

          4. Written informed consent to trial participation

        Exclusion Criteria:

          1. Females who are pregnant or lactating

          2. Inability to obtain consent from the patient or patient's designated representative.

          3. Inability of the patient to comply with the protocol.

          4. Previously documented adverse reaction to talc or cathflo activase.

          5. Oral or intravenous steroid therapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Transcranial Static Magnetic Field Stimulation (tSMS) in Amyotrophic Lateral Sclerosis (ALS). (NCT04393467)

Eligibility criteria:
Inclusion Criteria:

          -  age between 18 and 75 years

          -  diagnosis of ALS according to revised El Escorial criteria and Awaji-Shima criteria

          -  disease duration < 24 months

          -  ALSFRS-R > 30 at the recruitment

          -  ALSFRS-R decline > 1 in the at least 3-months period before the intervention

          -  normal respiratory functionality (FVC > 80% and ALSFRS-R items 10,11,12 > 4) at the
             recruitment

          -  treatment with riluzole 50 mg x 2/die

        Exclusion Criteria:

          -  inclusion in other clinical trials

          -  presence of tracheotomy or/and PEG (percutaneous endoscopic gastrostomy)

          -  contraindications to magnetic fields exposure

          -  pregnancy or breast-feeding

          -  history of epilepsy or seizures

          -  assumption of drugs acting on central nervous system, except for antidepressive drugs
             and benzodiazepines.

          -  cognitive impairment

          -  lack of informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Register of Patients With haEmophilia A tReated With Afstyla® (NCT04675541)

Eligibility criteria:
Inclusion Criteria:

          -  Have given their agreement to take part in the observational registry after being
             informed in writing of the purposes of the study and after their data have been
             recorded (parent's agreement for minor patients);

          -  Be suffering from haemophilia A and being treated or having been treated with Afstyla®
             long term prophylactically, on demand or preventatively for a surgical procedure;

          -  Absence of inhibitor and/or treatment for immune tolerance at the time of inclusion

        Exclusion Criteria:

          -  Refusal of the patient or the patient's legal representative to take part in the
             study;

          -  Existence of a contraindication to the use of Afstyla® treatment (known
             hypersensitivity to FVIII or hamster proteins);

          -  Simultaneous participation in an interventional clinical study.

          -  Presence of an inhibitor and/or ongoing immune tolerance.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Creation of a Bank of Fibroblast From Patients With Amyotrophic Lateral Sclerosis: Pilot Study (NCT01639391)

Eligibility criteria:
Inclusion Criteria:

          -  patients over 18 years old

          -  ALS sporadic or familial or unknown

        Exclusion Criteria:

          -  known cutaneous disease not allowing the biopsy

          -  platelets less than 10 000/m3

          -  suspected or known xylocain allergy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Investigating the Impact of Obesity on Pubertal Development in Girls (NCT02583646)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Girls without a chronic medical condition

          -  Normal weight (BMI 5th-85th%) or overweight/obese (BMI > 85th%)

          -  8-14 years old

          -  Some breast development

          -  Pre-menarchal

        EXCLUSION CRITERIA:

          -  Treated with medications that may affect reproductive hormones (e.g. birth control
             pills).

          -  Pregnancy

        During the study, the PI s discretion may be used to determine final eligibility. The PI s
        discretion may be used at any point in the study (pre-screening, clinical/lab assessments,
        etc.) to ensure participants are not subjected to unnecessary procedures or visits.
Female
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 14 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Within-Breath Total Respiratory Input Impedance in Healthy Adult Subjects (NCT04140825)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects ≥ 18 years of age.

          -  Signature of the written informed consent

        Exclusion Criteria:

        Subjects will be excluded if they meet at least one of the following conditions:

          -  Abnormal spirometry defined as FEV1, FEV1/VC and VC below the LLN as established by
             the Global Lung function (GLI) 2012 reference equations.

          -  Smokers or ex-smokers

          -  BMI >30 kg/cm2

          -  History of respiratory symptoms using the ECRHS II screening questionnaire
             (www.ecrhs.org)

               -  Wheezing

               -  Cough

               -  Phlegm production

               -  Dyspnea

               -  Feeling of chest tightness

               -  Night awakening due to a cough attack

          -  Have a history of pulmonary or cardiac disease

          -  Had a recent (e.g., in the last 4 weeks) respiratory tract infection

          -  Have a neurological or neuromuscular disorder
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Multi-omics Study of Adenomyosis (NCT03742843)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed adenomyosis and/or endometriosis

          -  Signed an approved informed consents

          -  Feasible for biopsy

        Exclusion Criteria:

          -  Not meeting all of the inclusion criteria
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Socialization of Adult Men With Congenital Hemophilia A or B (NCT01510418)

Eligibility criteria:
Eligibility criteria for person with congenital bleeding disorder(PWCBD, men with
        congenital hemophilia):

          -  Known diagnosis of congenital hemophilia A or B with or without inhibitor (defined by
             a plasma factor VIII or factor IX level below lower limits of normal and medical
             history consistent with diagnosis).

          -  Male age 21 years or older

          -  Willing to indicate if they have a spouse or significant other.

          -  Able to read, write and participate in interview on site.

        Exclusion Criteria for PWCBD:

          -  Other bleeding disorder besides congenital hemophilia A or B

        Eligibility criteria for spouses/significant other (SSO) participants in the study:

          -  A person in a relationship for a minimum of 9 months with the PWCBD participating in
             the study.

          -  PWCBD partner must be participating in the study.

          -  Willing to participate in questionnaire and interview on site.

        Exclusion criteria for SSO:

        - Biologically related to PWCBD participant (that is, not a parent, sibling, child or other
        biologically-related caregiver).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss (NCT04558268)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with unexplained RPL.

          -  Patients with abnormal immunological profile, including ANA, RF, anti-DNA,
             antilymphocyte, anticardiolipin, antithyroid and lupus anticoagulant antibodies that
             have no other clinical manifestation.

          -  Women with three or more pregnancy losses (before 24 weeks of gestation) who referred
             to the RPL clinic in Soroka hospital.

          -  An age above 25 years.

          -  The women agreed to participate in the study and signed on a consent form.

          -  women with index pregnancy.

        Exclusion Criteria:

          -  Presence of any genetic impairment, Mullerian anomaly, endocrine or metabolic
             disorders, or a luteal-phase defect (as determined by a timed endometrial biopsy).

          -  Diabetes mellitus diagnosed by symptoms of diabetes plus random glucose concentration≥
             200mg/dL or fasting plasma glucose≥ 126mg/dL or hemoglobin A1C≥5.8% or 2-h plasma
             glucose≥ 200mg/dL during an oral glucose tolerance test.

          -  Previously untreated tuberculosis, as determined by an abnormal chest film in the
             previous year or a positive tuberculin skin test.

          -  Prednisone therapy during pregnancy for other reasons.

          -  Sensitivity to prednisone.
Female
Accepts Healthy Volunteers
Subject must be at least 25 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Entailment
Clinical trial: Predicting Severity and Disease Progression in Influenza-like Illness (Including COVID-19) (NCT04664075)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy persons aged ≥ 18, and able to give informed consent

          -  Patient is admitted to hospital

          -  Primary reason for hospital admission is clinical suspicion of a new episode of ARI

          -  Onset of the following symptoms within the last 7 days: i. Sudden onset of
             self-reported fever OR temperature of ≥ 38°C at presentation AND ii. At least one
             respiratory symptom (cough, sore throat, runny or congested nose, dyspnoea) AND iii.
             At least one systemic symptom (headache, muscle ache, sweats or chills or tiredness).

        Exclusion Criteria:

          -  Patient lacks capacity to provide informed consent

          -  Patient has been transferred from another hospital

          -  Patient has been previously enrolled in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction