araag2/NLI4PR huggingface dataset:
Clinical trial: Psychological Strengths and Burden Among Osteoarthritis Patient (NCT03899272)

Eligibility criteria:
Inclusion Criteria:

          -  all new patient present to AHNH clinic referred for osteoarthritis for considering
             joint replacement

          -  Present with knee pain (unilateral or bilateral) contributed by osteoarthritis

        Exclusion Criteria:

          -  mentally unsound

          -  dialectic speaker that difficult to communicate
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Correlation of Endoscopic Findings and Symptoms in Patients Undergoing the First Upper Gastrointestinal Endoscopy (NCT03736824)

Eligibility criteria:
Inclusion Criteria:

          -  Patients undergoing the first upper gastrointestinal endoscopy.

        Exclusion Criteria:

          -  The patients had previously performed endoscopy and any esophageal, gastric or
             duodenal surgery.

          -  The patients couldn't complete the questionnaire survey under the guidance of
             physicians at the appointment of the upper gastrointestinal endoscopy.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Prospective Follow-up Study of the Aortic Diameter in Patients With Giant Cell Arteritis (NCT01588483)

Eligibility criteria:
Inclusion Criteria:

          -  patients with a first episode of biopsy and/or scintigraphy proven giant cell
             arteritis

          -  patients with a previous diagnosis of giant cell arteritis, in whom a yearly computed
             tomography of the aorta is available can opt to participate in this study

          -  informed consent form has to be signed by all patients

        Exclusion Criteria:

          -  patients already treated with steroids before performance of PET-scintigraphy

          -  earlier episodes of giant cell arteritis, without documentation of the aortic diameter
             at that moment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparative Study Between Minidose Long Protocol and Microdose Flare Protocol in Controlled Ovarian Hyperstimulation (NCT02342197)

Eligibility criteria:
Inclusion Criteria:

          -  Age > 35 years

          -  Day 3 serum FSH level > 10m IU/ml

          -  Number of antral follicles measuring 4-8mm during the early phase < 6

          -  Small ovarian volume

          -  AMH < 1

          -  Prior poor ovarian response to COH (oocytes < 5)

        Exclusion Criteria:

          -  Polycystic ovarian syndrome patients

          -  Patients with Endometriosis

          -  Normal responders to ovulation induction

          -  Patients having ovarian cyst

          -  Patients receiving ovulation induction in the preceding cycle
Female
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 42 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Predictive Value of Alarm Symptoms in Patients With Dyspepsia Based on Roman IV (NCT03479528)

Eligibility criteria:
Inclusion criteria:

          1. Aged 18 years and older;

          2. Presence of dyspeptic symptoms according with Rome IV criteria (Discomfort was
             characterized by the presence of one or more symptoms that included bothersome
             postprandial fullness, bothersome early satiation, bothersome epigastric pain,
             bothersome epigastric burning, Symptoms had to be present for at least 3 months within
             the preceding 6 months);

          3. From March 2018 to January 2019, patient went to the Gastroenterology clinics of the
             second affiliated hospital of xi'an jiaotong university, Xijing Hospital, Tangdu
             Hospital, Xi'an No.3 Hospital, and received gastroscopy;

          4. Upper abdominal ultrasonography, blood routine examination, liver function test were
             conducted within six months.

        Exclusion criteria:

          1. History of esophagitis or ulcer disease or other organic upper gastrointestinal
             disease, pancreaticobiliary disease, metabolic disease(abnormal thyroid function,
             diabetes );

          2. Were pregnant, might become pregnant, or were lactating;

          3. Major abdominal surgery;

          4. Severe neurological disorder, psychological diseases; or with severe hepatic, renal or
             respiratory dysfunction;

          5. Known or suspected liver dysfunction, including NASH, HBV or HCV-related hepatitis;

          6. History of gastroscope within 1 year;

        (6) Current antidepressant, steroids or NSAID use; (7) Patients who had only reflux-related
        symptoms or who had predominantly reflux-related symptoms; (8) Not willing to participate
        in the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Revival of Stem Cells in Addison's Study (NCT01371526)

Eligibility criteria:
Inclusion Criteria:

          -  Established autoimmune adrenal failure for >1yr age 16 to 65

        Exclusion Criteria:

          -  Significant cardio-respiratory, chronic renal or non-autoimmune liver disease;
             malignancy

          -  Asthma, current infectious disease, recent live vaccination, acute psychosis, peptic
             ulcer disease

          -  Pregnancy, breast feeding or plan for pregnancy within 9 months

          -  Known non-autoimmune cause for adrenal failure (haemorrhage, adrenoleukodystrophy
             etc.)

          -  Known hypersensitivity or allergy to Synacthen
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 66 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effects of Sand Treatment on Osteoarthritis (NCT03943303)

Eligibility criteria:
Inclusion Criteria:

          -  Joint pain related to daily activities;

          -  No morning joint stiffness greater than 30 minutes;

          -  Age between 30 and 95 years.

        Exclusion Criteria:

          -  History of previous knee surgery.

          -  History of fracture in the knee region.

          -  History of any secondary OA associated with any cystic arthropathy.

          -  Any treatment for the knee with methotrexate.

          -  History of hemorrhagic disorders.

          -  History of any infiltration of the knee during the previous 6 months (eg
             corticosteroids and hyaluronic acid).

          -  Morbid obesity.

          -  History of severe psychiatric disorders.

          -  History of skin cancer.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 95 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: A Two-stage Translation of the Chinese Version Menstrual Distress Questionnaire (NCT04452227)

Eligibility criteria:
Inclusion Criteria:

          1. A eumenorrheic healthy woman with a regular menstrual cycle for three months,
             predictable, and a period between 24-38 days that lasts less than 8 days.

          2. No hormonal contraceptives have been used in the past six months.

          3. No history of smoking, drinking or drug abuse.

        Exclusion Criteria:

          1. Women with systemic diseases, cardiovascular diseases, liver diseases, kidney
             diseases, diabetes or thyroid diseases.

          2. Taking any medicine due to chronic disease

          3. Women with mental illness
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Light Intensity Physical Activity Trial (NCT03415880)

Eligibility criteria:
Inclusion Criteria:

          -  40-70 years old

          -  having type 2 diabetes

          -  BMI 20-35 kg/m2

          -  having a sedentary lifestyle (i.e., self-reported moderate-to-vigorous physical
             activity < 150 minutes per week)

          -  willingness to undergo randomization

          -  being in the possession of personally owned smart phone

        Exclusion Criteria:

          -  not being able to walk for 15 minutes for any (medical) reason

          -  currently engaged in an (medical) exercise program

          -  plan to move out of the study area in the next 12 months

          -  (digital) illiteracy or being unable to read Dutch

          -  a history of any cardiovascular event (including stroke) three months prior to
             possible inclusion

          -  a history of signs or symptoms of ischemic heart disease and(or) heart failure three
             months prior to possible inclusion

          -  a history or signs or symptoms of peripheral arterial disease three months prior to
             possible inclusion

          -  a history or signs or symptoms of severe diabetic neuropathy or diabetic foot ulcers
             three months prior to possible inclusion

          -  a history of sign or symptoms of severe diabetic retinopathy three months prior to
             possible inclusion

          -  a history or sign or symptoms of severe osteoarthritis or severe joint complaints
             three months prior to possible inclusion

          -  a history or signs or symptoms of COPD (eligible are those participants with a COPD
             Gold classification ≤ I)

          -  uncontrolled diabetes (i.e., uncontrolled hypo- or hyperglycaemia)

          -  uncontrolled hypertension (i.e., systolic / diastolic blood pressure ≥ 180 / 95 mmHg)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Hemochromatosis--Genetic Prevalence and Penetrance (NCT00006312)

Eligibility criteria:
No eligibility criteria
Male
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment