araag2/NLI4PR huggingface dataset:
Clinical trial: MRI QSM Imaging for Iron Overload (NCT04631718)

Eligibility criteria:
Inclusion Criteria:

          -  Ages 10 years or older

          -  Known or suspected iron overload.

          -  Past serum ferritin > 500

        Exclusion Criteria:

          -  Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic
             implants, claustrophobia, etc)

          -  Pregnant or trying to become pregnant (as determined by self-report during MRI safety
             screening)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment
Clinical trial: Power Morcellation Systems for Laparoscopic Hysterectomy and Myomectomy (NCT02777203)

Eligibility criteria:
Inclusion Criteria:

          -  adult premenopausal women (equal or greater than 18 years old)

          -  no symptoms of menopause

          -  undergoing robotic or laparoscopic total or supracervical hysterectomies or
             myomectomies for the indication of symptomatic uterine fibroids

          -  not candidates for specimen removal via mini-laparotomy incision (as deemed by the
             study surgeon) or who have refused mini-laparotomy

          -  endometrial biopsy with no suspicion for malignancy

        Exclusion Criteria:

          -  known or suspected malignancy

          -  peri- or post-menopausal women

          -  specimen that can be removed without power morcellation (e.g., vaginally or through
             laparoscopic trocars)

          -  adults unable to consent.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study of the Safety and Effectiveness of Infliximab (Remicade) in Patients With Giant Cell Arteritis (NCT00076726)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who have a diagnosis of Giant Cell Arteritis (GCA)

          -  Patients who have a diagnosis of GCA of = 4 weeks' duration

          -  Patients who are receiving = 40 mg/day of prednisone/prednisolone Exclusion Criteria:

          -  Patients must not have a prior diagnosis of GCA > 4 weeks

          -  Patients must not have failed to respond to glucocorticosteroid therapy within 5 days
             of initiation of therapy.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: Protopic Adherence and Efficacy in Korean Eczema Patient (NCT02126176)

Eligibility criteria:
Inclusion Criteria:

          -  at least 19 years of age with a diagnosis of atopic dermatitis

          -  treated with protopic 0.1% ointment

        Exclusion Criteria:

          -  treated with other medication or topical agent

          -  skin lesion on the scalp or hand and foot

          -  pregnant women/lactating women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Patient description (medical language): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient description (patient's own words): I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Does the patient match the trial criteria? Contradiction
Clinical trial: Abnormal Movements, Cerebellum and Sensorimotor : Oculomotor Study (NCT01495897)

Eligibility criteria:
Inclusion criteria:

          -  Age ≥18 years

          -  -normal cognitive functions (>24y)

          -  Normal clinical examination of ocular mobility, visualization of the target

          -  No drug potentially able to modify and to influence the data: anti-depressants,
             neuroleptics, anti-emetics, amphetamines, anti myoclonic/dystonic drugs, alcohol,
             dopaminergic drug, antiepileptic.

          -  Dystonia or essential tremor or Parkinson: diagnostic made by a neurologist

          -  For DYT11: mutation in SGCE gene.

          -  For dystonia: No secondary dystonia

          -  For Parkinson : UPDRS<28

          -  No other neurological disorder

        For the patient having deep brain stimulation:

          -  Duration of stimulation> 6 months

          -  Cerebral imagery post operation made

          -  Stimulation parameter stable since 3 months at least.

          -  Usual stop of the stimulation during the night

        Exclusion criteria:

          -  Uncontrollable medical problems not related to M-D

          -  Current active psychiatric disorder

          -  Intake during the last 3 days of drugs potentially able to modify and to influence the
             data: anti-depressants, neuroleptics, anti-emetics, amphetamines, anti
             myoclonic/dystonic drugs, alcohol, dopaminergic drug

          -  Subjects legally protected.

          -  Subjects who are not enrolled at social security.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Impact of Head of Bed Elevation in Symptoms of Patients With Gastroesophageal Reflux Disease (NCT02706938)

Eligibility criteria:
Inclusion Criteria:

          -  Esophageal erosions

          -  Retrosternal pyrosis lasting ≥ 3 months

          -  Pyrosis and/or regurgitation with a frequency ≥ 3 nights per week

          -  GERD-associated sleep disturbance (insomnia, poor sleep quality) lasting ≥ 1 month

          -  GERD-associated sleep disturbance (insomnia, poor sleep quality) with a frequency ≥ 3
             nights per week

        Exclusion Criteria:

          -  Non-erosive gastroesophageal reflux disease (NERD)

          -  Peptic ulcer

          -  History of upper gastrointestinal surgery (except for cholecystectomy)

          -  Lactating or pregnant women

          -  Nighttime shift workers (12 am to 6 am)

          -  Obstructive sleep apnea hypopnea syndrome

          -  Chronic obstructive pulmonary disease

          -  Patients with nocturnal supplementary oxygen requirement

          -  Orthopnea

          -  Restless legs syndrome

          -  Patients consuming more than 3 cups of coffee per day

          -  Patients planning to travel beyond 3 time zones during study

          -  Patients being treated with sleep medication (e.g. anxiolytics, antihistamines,
             benzodiazepines) for less than 3 months

          -  Patients being treated with sleep medication (e.g. anxiolytics, antihistamines,
             benzodiazepines), when suspension or dose modification of this drugs is being planned
             during the study course
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: A Randomized, Parallel-Group Comparison Study of Topical Corticosteroids in Dry Eye Patients With Sjögren Syndrome (NCT02011776)

Eligibility criteria:
Inclusion Criteria:

          -  willing to participate in this clinical study, and signed informed consent

          -  age from 18 to 70 years old,both genders are permitted

          -  diagnosed as the Sjögren syndrome

          -  have the symptoms and signs of dry eye disease as below:

               1. have at least 2 symptoms such as dryness,foreign body sensation ,eye
                  strain,conjunctival congestion,secretion.The summed up score of symptoms greater
                  than 6.

               2. the score of tear-film break up time less than 5 seconds or the score of Schirmer
                  test less than 5mm/5min.

               3. the score of corneal fluorescein staining greater than 3.

                  Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluation of Respiratory Specimens for Bacterial and Viral Pathogens by Real-Time PCR (NCT00275691)

Eligibility criteria:
Greater than 18 years of age. Cough present greater than one day and a history of fever and
        chills or documented fever in the Emergency Department
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Desmopressin for Bleeding Related to Low Body Temperature (NCT00902057)

Eligibility criteria:
Inclusion Criteria:

        1. Healthy volunteers

        Exclusion Criteria:

          1. Any known platelet or coagulation disorder.

          2. Pregnant or lactating women.

          3. Known chronic liver or renal disease.

          4. Coronary artery, carotid artery or peripheral artery disease

          5. Recent history of taking antiplatelet drugs, anticoagulants or herbal preparations.

          6. Smoker or alcohol user

          7. Mentally incapable of providing informed consent

          8. Students or junior staff members who had direct working relationship with the PI
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Montelukast for Persistent Cough in Young People and Adults (NCT01279668)

Eligibility criteria:
Inclusion Criteria:

          -  Male or Female, aged 16 years to 49 years inclusive.

          -  Presenting with a persistent cough of 2-8 weeks' duration without an established
             diagnosis (e.g. asthma, gastro-oesophageal reflux).

          -  Able to complete cough diary and study questionnaires.

        Exclusion Criteria:

          -  There is a contraindication to montelukast.

          -  Chronic severe disease which may cause persistent cough (eg cystic fibrosis,
             bronchiectasis, cardiac failure).

          -  Immunodeficiency/immunocompromised state.

          -  Pregnancy.

          -  Breastfeeding.

          -  Current smoker (i.e. stopped smoking less than 6 months ago).

          -  Regular medication associated with persistent cough (ACE inhibitors).

          -  The individual is in another clinical research study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 49 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction