araag2/NLI4PR huggingface dataset:
Clinical trial: Dynamic 4DCT to Examine Wrist Carpal Mechanics (NCT04402502)

Eligibility criteria:
Inclusion Criteria:

          -  fluent in English, capacity to provide consent,

          -  over the age of 18 years old, with no previous injury to either hand or wrist

        Exclusion Criteria:

          -  pregnancy and presence of neurological disorders, rheumatoid arthritis or comorbid
             health conditions that preclude completion of study measures
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Optimization of VIM Targeting in Essential Tremor Surgery (NCT03760406)

Eligibility criteria:
Inclusion Criteria:

          -  Severe essential tremor despite the optimal medical management

          -  Age between 18 and 75 years

          -  Normal MRI scan

          -  Mattis Dementia Rating Scale (MDRS) score ≥ 130

          -  Affiliation to the social security

          -  Signed informed consent

        Exclusion Criteria:

          -  Depression (Beck Depression Inventory scale > 20)

          -  Contra-indication to surgery or general anesthesia

          -  Cerebral atrophy on MRI scan

          -  Pregnant or breastfeeding women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of ACE-031 in Subjects With Duchenne Muscular Dystrophy (NCT01099761)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of DMD confirmed

          -  Ambulant

          -  Corticosteroid therapy for at least one year prior to study day 1 and on a stable dose
             and schedule for at least 6 months prior to study day 1

          -  Evidence of muscle weakness by clinical assessment

        Exclusion Criteria:

          -  Any previous treatment with another investigational product within 6 months prior to
             study day 1

          -  Any clinically significant cardiac, endocrine, hematologic, hepatic, immunologic,
             metabolic, urologic, pulmonary, neurologic, dermatologic, psychiatric, renal, and/or
             other major disease that is not related to DMD

          -  Inability to perform a whole body dual x-ray absorptiometry (DXA) scan
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Experimental Round Spermatid Injection (ROSI) to Treat Infertile Couples (NCT04298255)

Eligibility criteria:
Inclusion Criteria:

          -  Males with no elongated spermatids or spermatozoa present but with round spermatids
             present on TESE (Testicular Sperm Extraction)

          -  Male diagnosed with non-obstructive Azoospermia

          -  Male partner ≥18

          -  Female partner greater than 18 years of age and less than 38 years of age or Anti
             Mullerian Hormone (AMH) greater than 2 ng/ml.

        Exclusion Criteria:

          -  Males with obstructive azoospermia

          -  Males with presence an adequate number of elongated spermatids or spermatozoa
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparison of Intra-articular and Intra-tendinous Injections for Treatment of Lateral Epicondylitis (NCT02986646)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of lateral epicondylitis based on 2 or more of the following
             diagnostic criteria: tenderness over the lateral epicondyle; pain with resisted wrist
             extension; pain with resisted long finger extension.

          -  Symptoms lasting a minimum of 6 weeks

          -  Pain score of >= 3/10 using the Visual Analog Scale (VAS)

          -  Age >= 18 years

        Exclusion Criteria:

          -  History of prior elbow surgery

          -  History elbow fracture within the past year

          -  Elbow instability on physical examination

          -  Elbow arthritis on radiographs

          -  Compressive neuropathy in the affected extremity (i.e.carpal tunnel, cubital tunnel)

          -  Evidence of cervical myelopathy, radiculopathy or brachial plexopathy

          -  History of systemic inflammatory condition (i.e. rheumatoid arthritis or systemic
             lupus erythematosus)

          -  Allergy to study administered medications (steroid or lidocaine)

          -  Neoplasm

          -  Non-English speaking patients

          -  Inability to comply with study protocols and follow up.

          -  Pregnant female
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effect of Functional Lumbar Stabilization Exercises in Women With Menstrual Low Back Pain (NCT01932723)

Eligibility criteria:
Inclusion Criteria:

          -  Having low back pain LBP during menstrual phase (days 1-6) of the menstrual cycle.

          -  Suffering from low back pain during all menstrual cycles in the year before the study.

          -  No back pain or low back paiun at times other than the menstrual phase.

          -  Pain intensity during menstrual LBP greater than 5 in Numeric Pain Scale

        Exclusion Criteria:

          -  History of spinal surgery, spinal or pelvic fracture and hospitalization for severe
             trauma or car accident, urinary tract infection, vaginal infection and known
             neurological disorders.

          -  Pain intensity lesser than 5 in Numeric Pain Scale
Female
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Once-daily Oral Modified Release Hydrocortisone in Patients With Adrenal Insufficiency (NCT00915343)

Eligibility criteria:
Inclusion Criteria:

          -  Previously diagnosed (e.g. more than 6 months ago) primary adrenal insufficiency with
             a stable daily glucocorticoid substitution dose for at least 3 months prior to study
             entry

          -  Signed informed consent to participate in the study.

        Exclusion Criteria:

          -  Clinical or laboratory signs of significant cerebral, cardiovascular, respiratory,
             Hepatobiliary, pancreatic disease

          -  Clinically significant renal dysfunction

          -  Clinical or laboratory signs of significant gastrointestinal emptying or motility
             disease

          -  Any medication with agents which could interfere with hydrocortisone kinetics

          -  Pregnant or lactating women

          -  Regular dehydroepiandrosterone (DHEA) medication for the past 4 weeks

          -  Oral oestrogen medication for the past 4 weeks

          -  Deranged mineralocorticoid status
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: The C3I COVID-19 Project (NCT04506528)

Eligibility criteria:
Inclusion Criteria:

          -  COVID-19 positive PCR test

          -  a COVID-19 ICD-10-CM diagnosis code during a healthcare visit, or a COVID-19 positive
             antibody test

          -  Must be a patient in one of the 21 participating healthcare systems

        Exclusion Criteria:

          -  N/A
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Thalamic LFPs and VIM DBS in Essential Tremor: Correlation, Evolution, and Therapeutic Perspectives (NCT02264925)

Eligibility criteria:
Inclusion Criteria:

          -  Patients suffering from severe and disabling ET with serious impact on their quality
             of life (QoL).

          -  18-70 years old

          -  Free of evolutive and untreated psychiatric disorder

          -  Tremor must be predominant in the upper limbs although it can affect the lower limbs,
             head and voice.

          -  Affiliation to a social security system

          -  Written informed consent signed by the participant and the investigator (prior to any
             examination required by research)

        Exclusion Criteria:

          -  Parkinsonian tremor

          -  Pregnancy or lactating women

          -  Severe co-morbidity (cardiac, renal or respiratory failures, evolutive cancer)

          -  Impaired cognitive functions (score <130 on Mattis scale).

          -  Patients with severe atrophy or lesions on MRI

          -  Depression (Beck > 10)

          -  Participation in another clinical research for 18 months (after surgery)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: CYP2C19 Genetic Polymorphism on the Accuracy of Proton-Pump Inhibitor Testing (NCT00354757)

Eligibility criteria:
Inclusion Criteria:

          -  A consecutive series of patients with symptoms suggestive of GERD were enrolled from
             the Gastroenterology outpatient clinic in our institution. The typical GERD symptom
             was defined as heartburn and/or acid regurgitation of at least three episodes per week
             for a minimum of three months.

        Exclusion Criteria:

          -  Patients who received concurrent PPI treatment, had a medical contraindication to
             rabeprazole therapy, reported a history of peptic ulcer disease or gastrointestinal
             surgery, peptic ulcer disease or malignancy proven by endoscopy, the presence of alarm
             features (e.g., dysphagia, weight loss, bleeding, abdominal mass, and/or anemia), or
             who were unwilling or unable to provide informed consent were excluded from the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction