araag2/NLI4PR huggingface dataset:
Clinical trial: Audio-visual Stimulation for Sleep Promotion in Older Adults With Osteoarthritis Pain (NCT03441191)

Eligibility criteria:
Inclusion Criteria:

          -  60 years or older

          -  Having difficulty sleeping over the past three months (Insomnia Severity Index ≥ 8)

          -  Having osteoarthritis pain (Brief Pain Inventory Worst pain ≥ 4)

        Exclusion Criteria:

          -  Working night shift

          -  Previously diagnosed with a primary sleep disorder (Sleep Apnea or Restless Leg
             Syndrome).

          -  Seizure disorder

          -  Photosensitivity

          -  Dementia

          -  Diagnosis or other significant chronic illness beyond OA that would impact sleep

          -  Severe psychiatric disorder including a history of or current diagnosis of psychosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of the Effects Strengthening Exercises in Individuals With ALS (NCT00204464)

Eligibility criteria:
Inclusion Criteria:

          -  definite and/or probable diagnosis of ALS

          -  early stages of the disease

        Exclusion Criteria:

          -  history of neuromuscular dysfunction not related to ALS

          -  active, confounding medical conditions

          -  unwillingness or inability to comply with the protocol

          -  FVC of less than 90% predicted

          -  ALSFRS score of less than 30
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Tranexamic Acid Versus Epinephrine During Exploratory Tympanotomy (NCT04188184)

Eligibility criteria:
Inclusion Criteria:

          -  18 - 60 years old

          -  ASA (I and II)

          -  Hb level > 10 mg/dl

          -  elective ear exploratory tympanotomy surgery under general anesthesia.

        Exclusion Criteria:

          -  Allergy to TXA

          -  bleeding/coagulation disorders

          -  psychiatric illness

          -  acute and chronic renal failure

          -  heparin use within 48 hrs or aspirin use within seven days before surgery,

          -  pregnancy

          -  liver cirrhosis

          -  color blindness

          -  cardiac stent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Role of Wrist Based Blood Pressure Monitoring in Clinical Practice (NCT03862742)

Eligibility criteria:
Inclusion Criteria:

          -  ≥18 years of age

          -  Own an iOS or Android device

        Exclusion Criteria:

          -  Inability to give informed consent

          -  <18 years of age

          -  Inability to understand written English language

          -  Hypertensive urgency or emergency as an admission diagnosis
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of Respiratory Physiotherapy on Pleural Effusion (NCT01756742)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of pleural effusion based on the presence of a consistent radiological
             finding on simple posteroanterior and lateral chest X-rays, and decubitus lateral in
             cases of small PE.

        Exclusion Criteria:

          -  Non diagnosis of pleural effusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of Fear of Falling on Physical Performance and Quality of Life in Children With Duchenne Muscular Dystrophy (NCT03507530)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with Duchenne Muscular Dystrophy by a pediatric neurologist,

          -  Being volunteer,

          -  Being between 6 and 15 years old,

          -  Being between levels 1-5 according to the Brooke Lower Extremity Functional
             Classification developed to classify lower extremity functions in children with DMD,

          -  Being able to cooperate with the physiotherapist's directives.

        Exclusion Criteria:

          -  Being between levels 6-10 (children who do not have independent ambulatory ability)
             according to the Brooke Lower Extremity Functional Classification,

          -  Not being able to cooperate with the physiotherapist's directives,

          -  End of the volunteering.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 15 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of HICT and LIIT on Functional Strength and Weight Efficacy in Overweight and Obese Females (NCT04812340)

Eligibility criteria:
Inclusion Criteria:

          -  Females with BMI >25 kg/m2.

          -  Females not engaged in routine exercise programs in last 6 months

        Exclusion Criteria:

          -  Females who are using weight loss products.

          -  Females having uncontrolled diabetes, thyroid disease, arthritis, cardiac diseases,
             asthma, hypertension, and recent trauma would not be included in the study.

          -  Females who are pregnant would not be included in the study.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of Depression, Peptides, and Steroids in Cushing's Syndrome (NCT00004334)

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

          -  Patients aged 20 to 60 with spontaneous active Cushing's syndrome

          -  At least 2 weeks since medication with psychoactive effects or influence on cortisol
             metabolism by hepatic hydroxylating enzyme induction

          -  Antihypertensives allowed for severe hypertension

          -  No barbiturates

          -  No phenytoin
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Entailment
Clinical trial: iBeat Wristwatch Validation Study (NCT03711695)

Eligibility criteria:
Inclusion Criteria:

          1. Age ≥ 21 years and ≤ 85 years

          2. Able to understand and give informed consent.

          3. Subject is presenting for the following planned procedures:

        3.1 Group A (25 subjects): Subjects presenting for catheter ablation for cardiac
        arrhythmias (e.g. atrial fibrillation, supraventricular tachycardia, or ventricular
        tachycardia) 3.2 Group B (25 subjects): Subjects judged based on the clinical evaluation of
        high, greater than 75%, atrial pacing or ventricular pacing burden or known pacing
        dependence with planned device interrogation for: 1) pacemaker (single or dual chamber), 2)
        implantable cardioverter-defibrillator (single or dual chamber), or 3) cardiac
        resynchronization therapy with or without defibrillator (single or dual chamber plus left
        ventricular pacing).

        3.3 Group C (5 subjects): Subjects for clinically indicated defibrillation threshold
        testing (DFT) (with a transvenous or subcutaneous ICD lead system)

        Exclusion Criteria:

          1. Age < 21 years and > 85 years

          2. Unable to or refuse to give written informed consent

          3. Unwilling or unable to wear the smartwatch device on at least one wrist

          4. Uncorrected severe aortic stenosis or subaortic stenosis (including hypertrophic
             cardiomyopathy) with outflow tract obstruction > 50 mm

          5. New York Heart Association Class IV Heart Failure
No condition on gender to be admitted to the trial.

Subject must be at least 21 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of Visual Performance With Contact Lenses (NCT03705130)

Eligibility criteria:
Inclusion Criteria:

          -  18 to 39 years of age

          -  Best corrected visual acuity of at least 20/30

          -  Spherical equivalent refractive error in each eye of between -0.75 and -6.00 diopters
             sphere after vertexing to the corneal plane

        Exclusion Criteria:

          -  Greater than -1.00 diopter of refractive astigmatism at the corneal plane

          -  Any active anterior segment disease, pathology, or surgery affecting vision,
             refraction, or the ability to wear a soft contact lens

          -  History of ocular trauma or surgery causing abnormal or distorted vision

          -  Current Rigid Gas Permeable (RGP) contact lens wearers

          -  Unwilling to have eyes photographed or video recorded

          -  Pregnant and/or lactating females, by self-report
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: Verification of the Efficacy/Safety of the Dual Drug Delivery for Hearing Loss (NCT04766853)

Eligibility criteria:
Inclusion Criteria:

          -  Sudden hearing loss, ototoxic hearing loss, noise-induced hearing loss, meniere's
             disease patients with 25dB HL in pure tone audiometry

          -  Patients whose hearing has not been restored after standard treatment

          -  Patients do not participate in clinical trials within 6 months

        Exclusion Criteria:

          -  Patients with retrocochlear lesion

          -  Patients with history of hypersensitivity to the substance of this drug
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment