araag2/NLI4PR huggingface dataset:
Clinical trial: A Study to Evaluate the Safest Dose Range for FEIBA in Hemophilia A Patients With Inhibitors on Emicizumab (NCT04205175)

Eligibility criteria:
Inclusion Criteria:

          1. Male patients with congenital hemophilia A of any severity and any age.

          2. History of high titer factor VIII inhibitor (Bethesda unit >5)

          3. Currently prescribed bypassing agent therapy for bleed management.

          4. Current treatment with emicizumab for a minimum of 2 months without interruption.

        Exclusion Criteria:

          1. Active bleed requiring factor therapy at screening.

          2. Treatment with rFVIIa or aPCC 7 days prior to screening.

          3. Surgical procedure 14 days prior to screening.

          4. Current use of any medication other than emicizumab that could affect the coagulation
             system e.g. aspirin, anticoagulants, etc.
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Patient Education Manual on Patients With Knee Osteoarthritis. (NCT04598126)

Eligibility criteria:
Inclusion Criteria

          -  Idiopathic knee OA-I, II, &III

        Exclusion Criteria:

          -  Post Traumatic OA Knees

          -  Ligament instability

          -  Condromalacia patellae

          -  Knee replacements

          -  Cognitive impairment

          -  Rheumatoid arthritis

          -  Meniscus injury
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluation of Modified Treatment Regimens for Treatment of Heavy Menstrual Bleeding Using the HerOption® System (NCT00094536)

Eligibility criteria:
Inclusion Criteria:

          -  Pre-menopausal adult women 30 years of age or older who have completed childbearing

          -  Heavy or prolonged menstrual bleeding

          -  Willing and able to complete all follow-up exams as required by protocol

        Exclusion Criteria:

          -  Known or suspected endometrial cancer or pre-malignant change of the endometrium

          -  Untreated cervical dysplasia

          -  Hereditary malformations of the uterine cavity that would prevent insertion and/or
             placement of the cryoprobe

          -  Uterine myomas > or = to 3 cm in diameter

          -  Past history of invasive treatment for abnormal uterine bleeding or uterine myomas

          -  History of classical (not low transverse incision) cesarean section

          -  Active genital or urinary tract infection or acute pelvic inflammatory disease (PID)

          -  Intrauterine device (IUD) in place

          -  Other medical conditions could be exclusionary upon evaluation for study treatment
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pain and Quality of Life After Inguinal Hernia Repair: Laparoscopic Versus Open Repair. (NCT04211142)

Eligibility criteria:
Inclusion Criteria:

          -  primary inguinal hernia

          -  unilateral hernia

        Exclusion Criteria:

          -  bilateral hernia

          -  recurrent hernia

          -  incarcerated hernia

          -  large scrotal hernia

          -  known femoral hernia

          -  need for associated procedures

          -  not able to understand the questionaire

          -  immunosuppression (including corticosteroids, radiotherapy, chemotherapy)

          -  chronic renal failure (hemodialysis)

          -  active infection

          -  pregnancy

          -  allergy to polypropylene or cyanoacrylate

          -  patient's refusal and/or absence of informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluation of Image Quality Over Time After Injection of the ﬂuorescein Sodium for Confocal Laser Endomicroscopy (NCT01042171)

Eligibility criteria:
Inclusion Criteria:

          -  These subjects will include male or female aged between 18 and 60 years with
             indications for upper-endoscopy ,but without serious gastritis and other serious
             stomach lesions

        Exclusion Criteria:

          -  Complications such as gastric and/or duodenal peptic ulcer, stenosis

          -  Esophageal, gastric or duodenal cancer or other malignancy

          -  History of stomach surgery

          -  A history of bronchial asthma, or known allergy to fluorescein.

          -  Pregnant or breast-feeding (for females)

          -  Below 18 or above 60 years of age

          -  Severe comorbidities ( e.g. such as renal failure, congestive cardiac failure, liver
             cirrhosis).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Multi-factorial Analysis of the Follicular Fluid Milieu to Explore the Discrepant Effect of Follicular Fluid Endometrial Flushing on Outcome of Assisted Reproduction Trial (NCT02468258)

Eligibility criteria:
Inclusion Criteria:

          -  Inclusion criteria included age younger than 37 years, having a regular and proven
             ovulatory menstrual cycle with a length of 26-35 days and body mass index (BMI) of <35
             kg/m2, and serum FSH and estradiol were within normal range. Indications for IVF were
             tubal pathology, unexplained infertility, and male factor

        Exclusion Criteria:

        -
Female
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 37 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Molecular Basis of the Growth Axis in Short Stature (NCT00453245)

Eligibility criteria:
Inclusion Criteria:

          -  Patient with growth hormone deficiency
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 81 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effects of E-smoke on Levels of Endothelial Progenitor Cells and Microparticles in Healthy Volunteers (NCT02532894)

Eligibility criteria:
Inclusion Criteria:

          -  healthy subjects

          -  sporadic cigarette smoking (<9 cigarettes per month)

        Exclusion Criteria:

          -  Any form of cardiovascular disease

          -  Any form of pulmonary disease like asthma or COPD

          -  Any form of systemic or chronic disorder like rheumatologic or metabolic diseases.

          -  Active allergy within 4 weeks of the study

          -  Symptoms of infection or inflammation within 4 weeks of the study

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Telescopic Dissection vs. Balloon Dissection During Laparoscopic TEP Inguinal Hernia Repair (NCT03276871)

Eligibility criteria:
Inclusion Criteria:

          -  18 years of age or older

          -  Able to give informed consent

          -  Unilateral inguinal hernia

          -  Scheduled for elective inguinal hernia repair

          -  Eligible to tolerate general anesthesia

          -  Eligible to undergo minimally invasive inguinal hernia repair

          -  Willing to undergo mesh-based repair

        Exclusion Criteria:

          -  Younger than 18 years old

          -  Unable to give informed consent

          -  Bilateral Inguinal hernias

          -  Emergent inguinal hernia repairs ( acute incarceration or strangulation)

          -  Recurrent inguinal hernia with prior preperitoneal mesh

          -  Unable to tolerate general anesthesia

          -  Not eligible for minimally invasive inguinal hernia repair

          -  Not willing to undergo mesh-based repair
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Yeast Colonization and Infection in Patients With Inflammatory Skin Diseases (NCT04215458)

Eligibility criteria:
Inclusion Criteria:

          -  Legally competent women and men

          -  Age 18 years or older

        Exclusion Criteria

          -  Actual systemic or topical antifungal therapy

          -  Pregnant or lactating women
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Entailment
Clinical trial: Subacute Effect of Pharyngeal Pharmacological Sensory Stimulation in Elderly Patients With Oropharyngeal Dysphagia (NCT04741620)

Eligibility criteria:
Inclusion Criteria:

          -  More than 70 years old.

          -  Oropharyngeal dysphagia with impaired safety of swallow (penetration aspiration score
             higher or equal than 2).

          -  Patients able to comply with the study protocol.

          -  Signature or the written informed consent.

        Exclusion Criteria:

          -  Previous history of severe gastrointestinal diseases.

          -  Epilepsy or previous convulsive crisis episodes.

          -  Pacemaker or implanted defibrillator carriers.

          -  Cardiopulmonary instability.

          -  Oropharyngeal dysphagia of structural cause.

          -  Previous history of head and neck surgery.

          -  Neurodegenerative disease.

          -  Advanced dementia (GDS higher than 5).

          -  Gastroesophageal reflux.

          -  Taking drugs with effects on dopamine.

          -  Neoplasia or active infection.

          -  Alcohol, tobacco or drugs dependence.

          -  Participate or have participated in another interventionist clinical trial in the 4
             weeks prior to inclusion.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 70 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction