araag2/NLI4PR huggingface dataset:
Clinical trial: Effect of Therapeutic Joint Arthrocentesis on Pain and Quadriceps Function in Patients With Knee Osteoarthritis (NCT04146649)

Eligibility criteria:
Inclusion Criteria:

          1. Patients aged 18 years or older with moderate to severe knee effusion associated with
             underlying osteoarthritis (Outerbridge grade II or higher) that undergo therapeutic
             aspiration

          2. Patients with symptomatic primary total knee arthroplasty without infection (as
             verified by prior aspiration) with moderate to severe effusion electing for
             therapeutic arthrocentesis. Must be minimum of 3 months from index surgery to be
             included.

        Exclusion Criteria:

          1. Patients with effusion related to trauma or another underlying condition (ie.
             fracture, ligamentous injury, hemarthrosis)

          2. Patients with known history of gout or with synovial fluid samples testing positive
             for urate of calcium pyrophosphate crystals

          3. Patients with knee effusion associated with septic arthritis or periprosthetic knee
             infection as determined from knee arthrocentesis.

          4. Patients with inflammatory arthritis (ie. JIA, RA, psoriatic arthritis, etc).

          5. Patients with revision knee arthroplasty, unicompartmental arthroplasty or other
             repair/reconstruction surgery

          6. Patients with underlying muscular disorder (ie. Stroke, cerebral palsy, multiple
             sclerosis, polymyalgia, fibromyalgia, muscular dystrophy, etc.)

          7. Patients with symptomatic hip pain

          8. Patients with active cancer in the area

          9. Patients with pacemakers

         10. Patients who are pregnant
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Constitutional Delay of Growth and Puberty: Towards Evidence-based Treatment (NCT01797718)

Eligibility criteria:
Inclusion Criteria:

          -  Constitutional delay of growth and puberty

          -  Age 14 years or more

          -  mean testicular volume 2.5 ml or more and less than 4 ml

          -  serum testosterone level less than 5 nM OR

        as above, but serum testosterone 1 nM or more with normal DHEAS level, even if the mean
        testicular volume is less than 2.5 ml OR

        as above, but tanner stage G2 and testosterone level less than 3 nM

        Exclusion Criteria:

          -  Chronic diseases

          -  Primary or secondary hypogonadism

          -  Chromosomal anomalies

          -  Chronic medication that potentially adversely affects bone mineralization (excluding
             inhaled corticosteroid treatment)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Strategies for Patients With Osteoarthritis, by Using Assistive Technology and Exercises. (NCT03173989)

Eligibility criteria:
Inclusion Criteria:

          -  Kellgreen and Lawrence (KL) classification for I to III or painful IV osteoarthritis
             (with the use of orthoses for analgesia, in this case).

          -  Capacity to understand and agree to the consent form and questionnaires and
             evaluations.

        Exclusion Criteria:

          -  Patients who had undergone previous non-medical therapeutic treatment for OA of the
             hands;

          -  Who had undergone some surgical procedure in the region or were involved in another
             clinical trial;

          -  Patients with rheumatoid arthritis or other rheumatologic disease, any neurological
             problems.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy and Safety of Diclofenac Sodium Gel in Hand Osteoarthritis (NCT00171665)

Eligibility criteria:
Key Inclusion criteria:

        • Osteoarthritis of the hand

        Key Exclusion Criteria:

          -  Other rheumatic disease, such as rheumatoid arthritis

          -  Active gastrointestinal ulcer during the last year

          -  Known allergy to analgesic drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Laparoscopic Roux-en-Y Gastric Bypass and Gastro-esophageal Reflux (NCT02618044)

Eligibility criteria:
Inclusion Criteria:

          -  history of obesity exceeding 5 years

          -  documented previous weight loss attempts,

          -  body mass index (BMI)) of 40-50 kg/m2

          -  age of 18-60 years.

        Exclusion Criteria:

          -  contraindications to pneumoperitoneum

          -  large esophageal hiatal hernia

          -  pregnancy,

          -  drug or alcohol abuse,

          -  psychological disorders (e.g., bulimia, depression)

          -  hormonal or genetic obesity-related disease

          -  previous gastric surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparative Study on Self-adhesive Mesh for Open Inguinal Hernia Repair (NCT00960011)

Eligibility criteria:
Inclusion Criteria:

          -  Age above 18 and below 80

          -  Male or female patients

          -  Unilateral inguinal hernia

          -  First occurrence hernia

        Exclusion Criteria:

          -  Inguino-scrotal hernia

          -  Recurrent inguinal hernia

          -  Incarcerated hernia

          -  Bilateral inguinal hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Prospective Analysis of Eosinophilic Esophagitis in Patients Presenting With Dysphagia (NCT00256529)

Eligibility criteria:
Inclusion Criteria:

          -  Patients aged 18-90 presenting with dysphagia or food impaction

          -  Ability to undergo esophagogastroduodenoscopy and biopsies

          -  No significant cardiopulmonary disease, or other contraindication to EGD

        Exclusion Criteria:

          -  Contradiction to EGD and/or biopsies such as Boerhaave's syndrome, or history or
             bleeding disorder or elevated INR

          -  Inability to provide informed consent

          -  Esophageal varices
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of A Special Vessel Subtype in Bone Samples From Patients With Osteoporotic and Nonosteoporotic Fracture (NCT02750046)

Eligibility criteria:
Inclusion Criteria:

          1. Ages Eligible for Study: 65-75 Years

          2. Genders Eligible for Study: Woman

          3. Accepts Healthy Volunteers: NO

          4. Study Population: Female patients with hip fracture. -

        Exclusion Criteria:

          1. Malignancy or benign ovarian cysts

          2. Known chronic or systemic diseases

          3. Hormone therapy in the previous 3 months

          4. Bone metabolism and drug therapy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of First TIME Immunotolerance Induction in Severe Hemophilia A Patients With Inhibitor at High Risk of Failure: Comparison With FVIII Concentrates With or Without Von Willebrand Factor - RES.I.S.T. Naive (NCT01051544)

Eligibility criteria:
Inclusion Criteria:

          1. severe hemophilia A (FVIII<1%);

          2. male, any age;

          3. high responders (peak inhibitor levels > 5 BU);

          4. any inhibitor level at study enrolment;

          5. ability and willingness to participate in the study;

          6. at least one of the following risk factors for ITI failure:

               -  peak inhibitor titer > 200 BU

               -  titer at ITI start > 10 BU

               -  age > 7 years

               -  time between inhibitor occurrence and ITI > 2 years

          7. absence of high risk of cardiovascular, cerebrovascular or other thromboembolic events
             as deemed by the treating clinician.

        Exclusion Criteria:

          1. concomitant systemic treatment with immunosuppressive drugs;

          2. concomitant experimental treatment;

          3. previous ITI attempt;

          4. previous history of myocardial infarction and/or cerebral stroke.
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Assessment of Digital Imaging as a Tool for Diagnosing Psoriasis, Hand Rashes and Unusual Moles (NCT00005781)

Eligibility criteria:
Must have employee status at the National Institutes of Health.

        Age greater than 18 years.

        Able to understand and sign consent.

        Patients who are wheelchair bound and are unable to have images of their back and lower
        extremities taken safely will be excluded from photography since this portion of the
        examination requires an ability to stand. However, they will still be eligible to
        participate in the skin cancer screening.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient description (patient's own words): I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Does the patient match the trial criteria? Contradiction