araag2/NLI4PR huggingface dataset:
Clinical trial: Autoimmunity in Inner Ear Disease (NCT00000361)

Eligibility criteria:
Inclusion Criteria:

          -  Have sensorineural (nerve/inner ear) hearing loss of at least 30 dB in each ear, which
             has rapidly progressed.

          -  Are in good general health.

          -  Are sterile or use contraception (if a woman of child-bearing age).

          -  Are able to speak and understand English or Spanish.

        Exclusion Criteria:

          -  Have had any previous reaction to prednisone, or history of psychiatric reaction to
             corticosteroids.

          -  Have used corticosteroids for more than 30 days within the past 90 days. Patients who
             have been off corticosteroids for at least 30 days may be eligible.

          -  Have any significant heart, lung, digestive, blood, or neurologic disorders.

          -  Have tuberculosis (TB), brittle or unstable insulin-dependent diabetes mellitus,
             active malignancy or prior chemotherapy, pancreatitis, active peptic ulcer disease,
             kidney failure, history of shingles, or known (other) autoimmune disease.

          -  Have had a positive test for HIV, hepatitis C or B.

          -  Have any type of middle ear disorder.

          -  Are breast-feeding or pregnant.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction
Clinical trial: Photodynamic Therapy for the Treatment of COVID-19 (NCT04416113)

Eligibility criteria:
Inclusion Criteria:

          -  Hospitalized patients with Positive COVID 19 test suffering from Fever, cough,
             shortness of breath, chills, muscle pain, the new loss of taste or smell, vomiting or
             diarrhea, and/or sore throat

        Exclusion Criteria:

          -  Patients in critical cases who admitted to the ICU, bacterial pneumonia, and
             respiratory distress grade III, IV, and patients on a mechanical ventilator.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Weight-based Dosing in Hemophilia A (NCT02586012)

Eligibility criteria:
Inclusion Criteria:

          1. Adult males age 18 or older.

          2. Hemophilia A (FVIII activity 40% or less).

          3. Overweight or obesity defined as a BMI of 25.0-29.9 and ≥ 30 mg/m2, respectively.

        Exclusion Criteria:

          1. Prior history of, or currently detectable, FVIII inhibitor defined as greater than or
             equal to 0.6 Bethesda Units (BU); however, a subject with a past low-level
             non-responding inhibitor defined as less than 5 BU, with no increase in titer
             following FVIII exposure, and not detectable within 12 months of the study, despite
             FVIII exposure during that period, will be allowed to enroll on study.

          2. Allergy to FVIII products.

          3. Current rFVIII requirements do not include at least a 72-hour period without rFVIII
             administration.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Ultrasound Evaluation of Bone Age in Healthy Children (NCT01980693)

Eligibility criteria:
Inclusion Criteria:

        Children aged 4-17 years old Children with normal (3%-97%) height values for their age
        Children with normal (3%-97%) weight values for their age Children with normal (5%-85%) BMI
        value for their age Children of Caucasian ethnical origin A signed Informed Consent Form
        that was obtained from at least one parent or legal guardian, prior to ultrasound study.

        An assent from the child to perform the SonicBone's BA device measurement

        Exclusion Criteria:

        Children taking any medication that might change bone metabolism or mineralization within
        the last year (glucocorticosteroids, sex steroids, oral contraceptives, anticonvulsants,
        calcium and vitamin D in superphysiological doses) Children with suspected bone diseases,
        metabolic diseases, chronic diseases or multiple fractures.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 4 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Tamoxifen Treatment in Patients With Motor Neuron Disease (NCT02166944)

Eligibility criteria:
Inclusion Criteria:

          1. Clinical diagnosed and confirmed ALS patients, with regular follow up and oral form
             riluzole at National Taiwan University or Shuang- Ho Hospital for more than 6 months.

          2. Age ≧20 years old

        Exclusion Criteria:

          1. Patients who had already ventilator dependent, not regular followed up for more than 6
             months or against medical advice, refuse to follow up at neurology department will be
             excluded in this study.

          2. Patients with now or previous usage of Tamoxifen

          3. Patients with any contraindications of Tamoxifen usage

          4. Patients with other internal medicine illiness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Longitudinal Follow up of Patients With Pleural Effusion (NCT04670562)

Eligibility criteria:
Inclusion Criteria:

          -  Patients presented with pleural effusion

          -  Patients who undergo thoracentesis and fluid analysis for diagnosis and management

        Exclusion Criteria:

          -  Patients who refuse to be enrolled
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Positive Exposure: A Photography and Video Intervention for Individuals With Craniofacial Differences (NCT00340964)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Participants must be at least 12 years old.

          -  Participants must have a clinically diagnosed craniofacial condition.

          -  Participants must be able to speak and write in English. However, if individuals have
             trouble writing (i.e. dyslexia or dysgraphia), they can tape record their personal
             reflections, which will be transcribed verbatim for analysis.

        EXCLUSION CRITERIA:

          -  If the individual is younger than 12 years of age.

          -  If the individual does not speak English.

          -  If the individual has been photographed by Rick Guidotti or another professional
             photographer in the past.

          -  If the individual has been video-interviewed by Diane McLean.

          -  If the individual has cognitive impairments that would preclude successfully
             completing the various steps of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 20 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: Prevalence of Pulmonary Embolism in Patients With Syncope (NCT01797289)

Eligibility criteria:
Inclusion Criteria:

          -  first episode of syncope

        Exclusion Criteria:

          -  previous episodes of syncope

          -  ongoing anticoagulation

          -  age younger than 18 years

          -  pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: Mifepristone and Misoprostol for Fetal Demise (NCT00177372)

Eligibility criteria:
Inclusion Criteria: healthy hemodynamically stable females with a non-viable pregnancy

        -

        Exclusion Criteria:

          -  orthostatic hypotension, contraindication to either mifepristone or misoprostol,
             treatment during current pregnancy to provide surgical or medical evacuation of the
             uterus, evidence of ovarian hyperstimulation syndrome, known or suspected pelvic
             infection,known or suspected clotting defect or receiving anticoagulants,
             cardiovascular disease, current breastfeeding, pregnancy with and IUD in situ, current
             participation in another clinical trial, prior participation in this trial, suspected
             or confirmed endometrial AV malformation, clinical indication requiring the
             karyotyping of products of conception
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Entailment
Clinical trial: The Impact of a Nutritional Supplement (Impryl®) on Male Fertility (NCT03337360)

Eligibility criteria:
Inclusion Criteria:

        Couples with failure to conceive for at least 12 months and starting with EM or Couples
        starting with 1st/ 2nd/3rd cycle of IUI (with/without ovarian stimulation) or Couples
        starting with 1st/ 2nd/3rd cycle of IVF/ICSI

        Furthermore:

          -  Male with age 18-50 years

          -  Female partner with age 18-43 years

          -  Willing and able to give informed consent

        Exclusion Criteria:

          -  Planned or performed diagnostic testicular biopsy (TESE) or percutaneous epididymal
             sperm aspiration (PESA)

          -  Use of donor-, cryopreserved- or electro-ejaculated semen

          -  Ovulation induction (OI) without IUI

          -  IVF for an absolute tubal factor

          -  Embryo-transfers after cryopreservation

          -  Embryo-transfer after pre-implantation genetic diagnosis

          -  Known genetic abnormalities related to infertility

          -  Known urological abnormality such as a varicocele or bilateral cryptorchism

          -  Use of other vitamin supplements
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient description (patient's own words): I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Does the patient match the trial criteria? Contradiction