araag2/NLI4PR huggingface dataset:
Clinical trial: Performance Evaluation of Von Willebrand:Collagen-Binding Assays to Diagnose Von Willebrand Factor Deficiency in Patients With Increased Risk of Bleeding (NCT02792205)

Eligibility criteria:
Inclusion Criteria:

          -  Patient with bleeding history sent to the Hemophilia Treatment Center in Dijon or
             Nantes University Hospital with abnormal bleeding score (>3 in men and >5 in women

          -  Patient who has provided a signed consent to participate at this study and for blood
             sampling

          -  Affiliation with French social security system

        Non-Inclusion Criteria:

          -  Minors will not be included in the study.

          -  On-going pregnancy and postpartum period (3 months after delivery)

          -  Substitutive treatment with coagulation factor concentrates or desmopressin
             administration within 10 days before sampling.

          -  Ongoing infectious or inflammatory disease that can modify VWF levels.

          -  Diagnosis of obvious hemostasis disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Genetic Association With Functional Dyspepsia and Mood Disorders (NCT02282995)

Eligibility criteria:
Inclusion Criteria:

          -  All subject

               -  Age 18-60

               -  Provision of written consent

        Additional to FD patient

          -  Symptoms fulfilling Rome III criteria of functional dyspepsia

          -  Negative upper endoscopy (oesophagogastroduodenoscopy or OGD) finding

        Exclusion Criteria:

          -  All subject

               -  History of cancer

               -  Diabetes mellitus

               -  History of gastric surgery

               -  Acid suppressants or medications that affect motility in past 4 weeks

               -  Organic disease as cause of dyspepsia (for subjects with dyspeptic symptom)

        Additional to healthy volunteer

        • Any gastrointestinal symptoms (including acid regurgitation, heartburn, epigastric pain,
        bloating sensation, constipation, abdominal pain, diarrhea) in the past 4 weeks

        Additional to FD patient

          -  Frequent (once or more per week) acid reflux or heartburn symptoms

          -  Helicobacter pylori (Hp) infection
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Validation of the Turkish Version of QUALEFFO-31 (NCT04259099)

Eligibility criteria:
Inclusion Criteria:

          -  To have Dual-energy X-ray absorptiometry (DXA) results and thoracolumbar lateral spine
             X-Rays taken for any reason in the last 6 months.

          -  To have calcium, phosphorus, parathormone (PTH) and 25-hydroxyvitamin D level in the
             last 3 months.

          -  To be independently ambulatory.

          -  To have a cognitive capacity to understand and complete the questionnaires.

        Exclusion Criteria:

          -  To have malignancy.

          -  To have inflammatory diseases.

          -  To have a metabolic bone disease other than osteoporosis.

          -  To have neuromuscular diseases.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Pilot Study of Non-exposure Simple Suturing EFTR With Sentinel Lymph Node Navigation for EGC (Senorita3-pilot) (NCT03216174)

Eligibility criteria:
Inclusion Criteria:

          -  single lesion of adenocarcinoma in preoperative endoscopic biopsy

          -  clinical stage T1N0 in the preoperative evaluation of endoscopy and computed
             tomography

          -  tumor size: less than 3cm in differentiated type, less than 2cm in undifferentiated
             type

          -  location: 2cm far from the pylorus or cardia

          -  aged 20 to 80

          -  ECOG 0 or 1

          -  patient who signed the agreement

          -  patient who is suspected to underwent laparoscopy assisted gastrectomy

        Exclusion Criteria:

          -  indication of endoscopic submucosal resection

          -  inoperable due to poor cardiac, pulmonary function

          -  pregnant

          -  having allergic reaction, previous upper abdominal surgery except laparoscopic
             cholecystectomy, previous radiation therapy to upper abdomen

          -  diagnosed as malignancy within 5 years except carcinoma in situ of cervix cancer and
             thyroid cancer
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: The Turkish Deglutition Handicap Index (NCT04296409)

Eligibility criteria:
Inclusion Criteria:

          -  Willing to participate

          -  Having swallowing problems

        Exclusion Criteria:

          -  Being under the age of 20 years, and above the age of 60 years

          -  Not willing to participate

          -  Having no swallowing problems
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: Staccato Loxapine PK in Smokers and Nonsmokers (NCT00873769)

Eligibility criteria:
Inclusion Criteria:

          -  Normal spirometry at screening and in good general health as determined by a complete
             medical history, physical examination, 12-lead ECG, blood chemistry profile,
             hematology, and urinalysis,

          -  Smokers must have a history of smoking > 15 cigarettes/day currently and for at least
             the last 2 years,

          -  Nonsmokers must have never smoked > 5 cigarettes/day and not smoking at all for at
             least the last 2 years.

        Exclusion Criteria:

          -  Any acute illness in the 5 days,

          -  Use of a bronchodilator for the treatment of wheezing within 12 months, OR

          -  Any other disease or condition, by history, physical examination, or laboratory
             abnormalities that would present undue risk to the subject, or may confound the
             interpretation of study results.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: SIngle Port vs Standard TEP for Primary Inguinal Hernia Repair (NCT02302937)

Eligibility criteria:
Inclusion Criteria:

        Age: 21- 80 yrs

          -  Informed consent

          -  Diagnosis of Hernia

          -  ASA I and II

          -  BMI<25.

        Exclusion Criteria:

        Bleeding disorders

          -  Age below 21

          -  Strangulated Hernia

          -  BMI > 30

          -  Incarcerated and obstructed hernia

          -  Recurrent hernia

          -  Bilateral hernia

          -  Previous LSCS

          -  Previous lower abdominal surgery
Male
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: The Phase 2 Study to Evaluate the Safety and Efficacy of Clevudine in Patients With Moderate COVID-19 (NCT04347915)

Eligibility criteria:
Key Inclusion Criteria:

          1. Over 19 years of age

          2. COVID-19 confirmed by a real-time RT-PCR tests 4 days prior to clinical trial
             enrollment

          3. Patients with peripheral capillary oxygen saturation (SPO2) greater than 94% at the
             time of screening

          4. Patients whose body temperature is measured according to the measured area without
             taking a fever reducer during screening:

             [armpit of greater than 37.0 °C or an oral of greater than 37.2 °C; Patients with
             rectum greater than 37.6 °C or eardrum greater than 37.5 °C] (Notes: Although you take
             a fever reducer, you can still be enrolled in after investigator's judgement whether
             there is fever or not.)

          5. Patients with evidence of lung invasions as a result of radiation tests

        Exclusion Criteria:

          1. Patients who need breathing device (for example, Invasive ventilation, Invasive
             mechanical ventilation, Extra-corporeal membrane oxygenation).

          2. Patients who participated in other clinical trials related to COVID-19.

          3. Patients who were administered drugs directly to COVID-19 24 hours prior to the start
             of the study.

          4. Patients whose AST or ALT has increased by more than 5 times the normal lab value.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Digestive Events in Duchenne Muscular Dystrophy Patients (NCT04384354)

Eligibility criteria:
Inclusion Criteria:

          -  all Duchenne muscular dystrophy patients in our center

        Exclusion Criteria:

          -  none
Male

Subject must be at least 15 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Economic Assessment of STarting Endoscopic Robotic Groin Hernia Repair (NCT04431271)

Eligibility criteria:
Inclusion Criteria:

          -  adult patients

          -  underwent uni-or bilateral groin hernia repair in the period 2015- 2019

          -  surgery through minimal invasive repair

        Exclusion Criteria:

          -  open surgery or conversion from minimal-invasive to open surgery

          -  combined procedures

          -  age below 18 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Computerized Evaluation of the Endometrial Myometrial Junction During a Natural Menstrual Cyle. (NCT02295917)

Eligibility criteria:
Inclusion Criteria:patients with regular menstrual cycles -

        Exclusion Criteria:patients on contraceptive pills.patients after uterine surgery

        -
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction