araag2/NLI4PR huggingface dataset:
Clinical trial: Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis (NCT00005766)

Eligibility criteria:
Inclusion Criteria:

          -  ALS

          -  FVC >=50%

          -  Abnormality in upper and/or lower extremity motor function

          -  Not pregnant

          -  Disease duration <5 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Quality of Life and Physical Performance After Novel Coronavirus Infection (COVID-19); (NCT04375709)

Eligibility criteria:
Inclusion Criteria:

          -  Hospitalized at the Kantonsspital Winterthur (KSW) due to COVID-19 infection
             (laboratory-confirmed),

               -  with or without mechanically assisted ventilation

               -  being at risk to obtain severe illness caused by the COVID-19*

               -  individuals without defined risk factors but requiring oxygenation during
                  hospitalisation

          -  Agree to general consent or specific consent to subsequent use of his/her personal
             health data for research purpose

          -  German-speaking

        Exclusion Criteria:

          -  Presence of mental disability or impairments to reasoning or judgment

          -  Individuals who are immunocompromised due to medical treatment

          -  A documented objection of subsequent use of personal health data

        Specific exclusion criteria for presence at the hospital (for evaluation and training);
        criteria will be verified during the phone-based screening process. After two weeks of a
        COVID-19 positive diagnosis and with four entire days the patient reports no signs of:

          -  fever >37.3° C

          -  sore throat,

          -  cough (productive or non-productive)

          -  common cold

        Also, treatment-based immunocompromised patients are excluded for on-site evaluation and
        training.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Home-Based Covid-19 Rehabilitation Program (NCT04406532)

Eligibility criteria:
Inclusion Criteria:

          1. Age 18 and older.

          2. Symptoms suggestive of Covid-19 infection (fever, cough, chest discomfort or loss of
             smell/taste).

          3. Covid-19 screening done.

          4. Ambulatory without assistive devices (such as cane or walker).

          5. Access to PT-Pal app via cellular phone, iPad or computer (e.g. Zoom™).

        Exclusion Criteria:

          1. Severe symptoms requiring referral to the Emergency Department.

          2. Contraindications to exercise (cardiac disease such as diagnosed arrhythmias, on home
             oxygen, or end stage organ failure).

          3. Known history of poorly controlled diabetes or hypertension.

          4. Active neurological or psychiatric illnesses.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Value of CA125 and Yolk Sac Morphology in Prediction of Pregnancy Outcome in Threatened Miscarriage (NCT03320213)

Eligibility criteria:
Inclusion Criteria:

          -  pregnant women between 20-40 years. Pregnancy between 6-10 weeks. single intrauterine
             spontaneous pregnancy. vaginal bleeding or bloody vaginal discharge with or without
             pelvic pain for patients with threatened miscarriage.

        Exclusion Criteria:

          -  medical disorders with pregnancy. History of recurrent miscarriage. Any maternal
             disease that would cause an increase in CA125 level. Local gynecological disorders
             e.g. fibroid. Presence of any uterine malformation. History of congenital
             abnormalities in previous pregnancy Presence of multiple pregnancy. Presence of
             anembryonic sac. Absent fetal heart pulsation.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy and Safety of QL1206 in the Treatment of Postmenopausal Osteoporosis With High Fracture Risk (NCT04128163)

Eligibility criteria:
Inclusion Criteria:

          1. Subject is willing to provide written informed consent.

          2. Ambulatory woman between the age of 50 and 85 years, inclusive.

          3. The subject has a BMD absolute value consistent with a T-score<-2.5 and >-4.0 at
             either the lumbar spine or total hip

          4. All subjects must have at least one of following additional the risk factors:history
             of fracture（after 40 years）,parental history of hip fracture, low Body mass index
             (BMI≤19kg/m^2), elderly (age≥65year)，current smoker

          5. Postmenopausal defined as >2 years postmenopausal, which can be >2 years of
             spontaneous amenorrhea or >2 years post surgical bilateral oophorectomy.

        Exclusion Criteria:

          1. Bone/metabolic disease:a. Any metabolic bone disease, e.g., osteomalacia or
             osteogenesis imperfecta,which may interfere with the interpretation of the findings.

             b. Paget's disease c. Cushing's disease d. Hyperprolactinemia

          2. Current hyperparathyroidism or hypoparathyroidism by medical record

          3. Thyroid condition: Hyperthyroidism or hypothyroidism.

          4. Rheumatoid arthritis

             -
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Imaging in the Diagnosis of Parkinson's Disease and Essential Tremor (NCT01446939)

Eligibility criteria:
Inclusion Criteria:

          -  Parkinson´s disease patients according to UK Parkinson´s Disease Brain Bank Criteria

          -  Essential Tremor Patients according to Movement Disorder´s diagnosis consensus
             criteria.

          -  Healthy Volunteers: paired with PD patients by age and gender.

        Exclusion Criteria:

          -  Contraindication to MRI

          -  Claustrophobia.

          -  Serious structural brain anomalies.

          -  Condition or situation in which, in the opinion of the investigator put the patient at
             significant risk, which can confound the results, or substantially interfere with the
             individual's participation in the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 45 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparative Study Between Single Versus Dual Trigger for Poor Responders in GnRH-antagonist ICSI Cycles (NCT04008966)

Eligibility criteria:
Inclusion Criteria:

          -  women with poor ovarian response candidate for ICSI

          -  women with spontaneous normal menstrual cycle

          -  normal uterine cavity

        Exclusion Criteria:

          -  women with ovarian cysts

          -  endometriosis

          -  hydrosalpinx

          -  endocrinological disorders as hyperprolactinemia, thyroid or adrenal disorders.

          -  Couples with azospermic male partner

          -  those with severe uncontrolled medical or metabolic disorders
Female
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 42 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Chinese Tuina Therapy for Treatment of Knee Osteoarthritis (NCT03966248)

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of KOA;

          2. Age 40-75 years;

          3. KL (Kellgren-Lawrence) grade Ⅱ or Ⅲ in recent 3 months;

          4. NRS score of pain at least more than 4 points;

          5. Single/bilateral knee pain, duration of more than 6 month; If the patient has KOA on
             both legs, the heavier leg is selected for study.

        Exclusion Criteria:

          1. Surgery history of knee or waiting for surgery (knee replacement or knee arthroscopy);

          2. Knee pain caused by other diseases (such as joint bodies, severe effusion of joint
             cavity, infection, malignant tumors, autoimmune diseases, trauma, etc.);

          3. Oral administration of hormones within 3 month, intra-articular injection within 6
             months, knee injuries or open injuries within 6 months, or knee arthroscopy within 1
             year.

          4. Severe acute/chronic organic or mental diseases;

          5. Pregnant women, pregnant and lactating women;

          6. Coagulation disorders (such as hemophilia, etc.), or the skin diseases at the site of
             operation;

          7. Device support treatment after knee osteoarthritis disability;

          8. Participation in another clinical study in the past 3 months;

          9. History of receiving acupuncture, massage, manipulation, or any medical plaster
             treatment within 3 months

         10. Breaks for treatment longer than 3-4 weeks depending on each circumstance or merit may
             be construed as non-compliance and may be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone (NCT01428089)

Eligibility criteria:
Inclusion Criteria:

          -  Female volunteers in early to mid-puberty (i.e., late Tanner I [estradiol level > 20
             pg/mL], Tanner II, or Tanner III)

          -  Premenarcheal

        Exclusion Criteria:

          -  Pregnancy

          -  Inability to comprehend what will be done during the study or why it will be done

          -  Hemoglobin less than 12 g/dl and hematocrit less than 36%

          -  Persistently abnormal sodium, potassium, or bicarbonate (i.e., confirmed on repeat)

          -  Persistently elevated creatinine, hepatic transaminases, or alkaline phosphatase
             (i.e., confirmed on repeat)

          -  Total bilirubin > 1.5 times upper limit of normal (i.e., confirmed on repeat)

          -  Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected
             congestive heart failure; asthma requiring intermittent systemic corticosteroids;
             etc.)

          -  Untreated hypo- or hyperthyroidism, reflected by persistently abnormal
             thyroid-stimulating hormone (TSH) values

          -  Total testosterone > 200 ng/dl

          -  Basal (follicular) 17-hydroxyprogesterone > 200 ng/ml (in girls without a previous
             diagnosis of congenital adrenal hyperplasia)

          -  Dehydroepiandrosterone sulfate (DHEA-S) > 800 mcg/dl

          -  Elevation of prolactin > 2 times upper limit of normal

          -  Weight less than 26 kg.
Female
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 14 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparative Study of LAVH and Minilaparotomy Hysterectomy (NCT03548831)

Eligibility criteria:
Inclusion Criteria:

          -  Non descent uterus with benign gynaecological conditions

        Exclusion Criteria:

          -  Uterine size > 20 weeks

          -  Minilaparotomy was contraindicated in patients where severe adhesions might exist eg -

               -  Endometriosis

               -  Previous pelvic inflammatory disease

          -  Patients with one or more contraindications for LAVH were excluded -

               -  Cardiac or respiratory morbidity contraindicating laparoscopy

               -  Frozen pelvis

               -  Cervix flushed with vagina
Female




Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment