araag2/NLI4PR huggingface dataset:
Clinical trial: Optimizing Treatment on Idiopathic Inflammatory Myopathies (NCT03092180)

Eligibility criteria:
Inclusion Criteria:

          -  Idiopathic inflammatory myopathies

        Exclusion Criteria:

          -  Inclusion body myositis, muscular dystrophies, neoplasia-associated myopathies,
             overlapped myopathies, others myopathies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient description (patient's own words): I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Does the patient match the trial criteria? Entailment
Clinical trial: Cerebellar rTMS for Essential Tremor (NCT02704793)

Eligibility criteria:
Inclusion Criteria:

          -  having a diagnosis of essential tremor (ET) based on Movement Disorder Society
             criteria, involving at least one hand.

          -  18 years or above

          -  cognitively eligible to give informed consent of participation in the trial.

        Exclusion Criteria:

          -  Cardiac pace-maker or other implanted magnetic device or having other
             contraindications of performing a routine non-contrast MRI

          -  skin defect at the occipital area preventing placement of a coil

          -  Currently pregnant or plan for pregnancy in the next 6 months

          -  History of seizure

          -  Other comorbid medical conditions capable of producing or enhancing tremor

          -  advanced cardiac, renal, hepatic or other disabling conditions making patient physical
             unable to participate in examination and receiving the intervention

          -  Use of new drugs with potential effect on tremor
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Screening for Osteoporosis in General Practice (NCT02220699)

Eligibility criteria:
Inclusion Criteria:

          -  Patient identified as being at an increased risk of osteoporosis by the data capture
             system

        Exclusion Criteria:

          -  Known osteoporosis.

          -  Patients treated with alendronate.

          -  Patients below 25 years of age.

          -  Bone metastasis.

          -  Terminal disease.

          -  Severe dementia or other disease or condition that is incompatible with participation.

          -  Bone mineral density scan within the past 3 years.

          -  Errors in their ICPC coding that leads to the patient being misclassified as having an
             increased risk of osteoporosis.

          -  Patients not wanting to participate.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study to Compare the Safety, Pharmacokinetics and Pharmacodynamics of HIP1802 to HGP1705 in Healthy Volunteers (NCT04324905)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy volunteers in the age between 19 and 50 years old.

          -  Body mass index (BMI) in the range of 19 to 28 kg/m2 and weight 55.0kg to 90.0kg.

          -  After fully hearing and understanding the details of this clinical trial, Subjects who
             have willingness to sign of informed consent before the screening.

          -  Subject who are eligible from physical examination, clinical laboratory test by
             investigators judgment.

        Exclusion Criteria:

          -  Gastrointestinal disorders (gastrointestinal ulcers, gastritis, stomach cramps,
             gastro-esophageal reflux disease, Crohn's disease or chronic pancreatitis) or
             gastrointestinal surgery (except for simple cecal or hernia surgery) which may affect
             the safety and pharmacokinetic evaluation of test drug.

          -  Subjects who have a history of hypersensitivity or clinically significant
             hypersensitivity to investigational product or the same component or other drugs
             (aspirin, antibiotics, etc.).

          -  Aspartate aminotransferase and alanine aminotransferase exceed 1.5 times the upper
             limit of normal range from screening laboratory results before randomization.

          -  Subject who continues to drink (21 units / week, 1 unit = 10 g of pure alcohol) within
             a month before the screening visit or who cannot abstain during the hospital stay.

          -  Heavy smoker (>10 cigarettes/day).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Pilot Study of a Homeopathic Therapy in Combination With Cyclosporin (Restasis) in the Treatment of Dry Eye Disease (NCT01072526)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of moderate to severe dry eye syndrome with or without Sjögren's syndrome

          -  receiving treatment with topical cyclosporine (Restasis)

          -  experience one or more moderate dry eye-related symptoms, including dryness, foreign
             body sensation, burning, blurred vision, photophobia, and soreness or pain

        Exclusion Criteria:

          -  history of ocular disorder including non-dry eye ocular inflammation, glaucoma,
             contact lens use

          -  trauma or surgery, including punctal plug insertion within the prior 3 months

          -  any uncontrolled systemic disease or significant illness

          -  use of topical ophthalmic medications that could affect dry eye syndrome

          -  pregnancy, lactation, or considering a pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Contradiction
Clinical trial: Epidemiology of Hearing Loss in Diabetic and Non-Diabetic Veterans (NCT00018486)

Eligibility criteria:
Any participants over 21 years of age and under 80 who do not have an end-stage disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Improved Delivery of Cardiovascular Care Through Outreach Facilitation (NCT00574808)

Eligibility criteria:
Inclusion Criteria:

          -  Men and women over 40 years of age, who meet at least one of the following criteria:

               1. have established cardiovascular disease: Coronary Artery Disease, Cerebrovascular
                  disease (documented stroke and/or TIA), and Peripheral Vascular Disease;

               2. have Diabetes Mellitus;

               3. have Chronic Kidney Disease ;

               4. are at high risk for CVD based on a presence of at least three of the following
                  established cardiovascular risk factors: age (males ≥ 45, females ≥ 55), smoker
                  status, hypertension, and dyslipidemia.

          -  No restrictions will be imposed on the recruitment process; all practices in the
             region will be eligible to participate.

        Exclusion Criteria:

          -  see above
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Neoadjuvant Chomotherapy With Paclitaxel-albumin and S-1 for Advanced Gastric Cancer (NCT04258657)

Eligibility criteria:
Inclusion Criteria:

          1. pathologically diagnosed gastric adenocarcinoma

          2. Type II and III esophageal-gastric-junction malignancy

          3. AJCC stage II-III

          4. No contraindications for surgery, radical resection can be expected

          5. KPS>60; ECOG score:0-2

          6. Expactant survival period>6 months

          7. Age 20~75

          8. No other major health issues

          9. Lab results within 7 days before inclusion must satisfy:

               1. neutrophil≥1.5×109/L

               2. PLT≥100×109/L

               3. hemogloblin≥90g/L

               4. ALT,AST<1.5 upper limit

               5. Tbil≤1.0×UNL

               6. serum creatinine<1.5×UNL

               7. PT-INR/PTT<1.7 upper limit

         10. with measurable lesion according to RECIST1.1 criteria

         11. with consent

         12. co-operative

        Exclusion Criteria:

          1. with other major health issue

          2. allergic to relevant drugs

          3. experienced any other drug therapy with 4 weeks before inclusion

          4. experienced any drug therapy for gastric cancer at anytime

          5. diagnosed with any other malignancy within the past 5 years

          6. women at child-bearing age; pregnant or breast-feeding women

          7. with severe heart disease

          8. with upper GI digestion or disrupted absorption

          9. with peripheral neural disease

         10. with transplated organs or organs having been resected for transplantation

         11. known DPD deficiency

         12. with uncontrolled infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Comparing Arthroscopic Tennis Elbow Release With Arthroscopic Debridement (NCT02236689)

Eligibility criteria:
Inclusion Criteria:

          -  Patients eligible for inclusion in the study will have had symptoms for at least 9
             months and have failed conservative management.

        Exclusion Criteria:

          -  Significant prior elbow trauma will be excluded alternative diagnoses that better
             explain their symptoms

          -  Patients who have had significant prior elbow trauma or surgery

          -  WSIB patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction