araag2/NLI4PR huggingface dataset:
Clinical trial: Study of Surgical Mesh for Inguinal Hernia Repair (NCT00924755)

Eligibility criteria:
Inclusion Criteria:

          -  male ≥19 years old

          -  symptomatic and palpable inguinal hernia

          -  candidate for unilateral, primary, open inguinal hernia repair using the Lichtenstein
             technique

          -  will comply with required follow-up study visits

          -  willing and able to provide written informed consent

        Exclusion Criteria:

          -  BMI ≥35

          -  life expectancy of <3 years

          -  strangulated hernia

          -  urologic disorder and/or previous urologic surgery in the testicular area (with the
             exception of prostate surgery)

          -  active abdominal surgical condition such as bowel obstruction or perforation

          -  local or systemic infection or peritonitis

          -  known disease that impairs wound healing

          -  anti-platelet therapy (other than aspirin) for >7 days preceding the surgical
             procedure

          -  previous ipsilateral groin incision

          -  receiving immunosuppressive therapy and/or has undergone radiation therapy to the
             affected groin area

          -  uncontrolled insulin-dependent diabetic with Hgb1Ac greater than 8

          -  advanced cirrhosis with Child-Turcott Class of C or higher

          -  severe COPD requiring home oxygen

          -  diagnosed with chronic pain syndrome or is undergoing treatment for pain management

          -  candidate for another major surgical procedure with the inguinal hernia repair

          -  enrolled in another investigational study that may confound the results of this study

          -  known drug abuser

          -  on anti-psychotic medications

          -  Worker's Compensation case
Male
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Investigating Signal Change in Malignant and Non-malignant Pleural Effusions and asCitic Fluid Using fTiR Analysis (NCT04533854)

Eligibility criteria:
Inclusion Criteria:

          -  Aged ≥18 years.

          -  A confirmed, clinician made diagnosis of the following (supported by standard accepted
             diagnostic criteria):

          -  Malignant pleural effusion: confirmed cancer

          -  lung cancer

          -  mesothelioma

          -  or metastatic cancer

          -  Non-malignant pleural effusion: effusion confirmed to be caused by alternative
             diagnosis

          -  Malignant ascites: confirmed cancer

          -  Non-malignant ascites: ascites confirmed to be caused by alternative diagnosis

          -  Willing and able to give informed consent for participation in the study.

        Exclusion Criteria:

          -  Unable to comprehend the study

          -  Unable to provide informed consent
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Remote Manipulation of a Capsule Endoscope (NCT01044797)

Eligibility criteria:
Inclusion Criteria:

          -  Asymptomatic adult volunteer with previously determined normal esophagus and stomach
             who understands the risks of the procedure.

        Exclusion Criteria:

          -  Known strictures in the intestine,

          -  Crohn's disease,

          -  Swallowing difficulty,

          -  Age less than 21,

          -  Age over 75 or have a pacemaker,

          -  Presence of implanted metal devices,

          -  Presence of esophageal or bowel disease or conditions that may preclude study
             participation as a matter of clinical judgment.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: Interferon-alpha Treatment of Chronic Cough in Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis (NCT00690885)

Eligibility criteria:
Inclusion Criteria:

        For all patients

          -  history of clinically significant chronic cough for > 3 months

          -  For COPD patients

          -  >40 years of age

          -  20-pack-year history of smoking

          -  GOLD classification of Stage 1 or higher

          -  For IPF patients

          -  > 50 years of age

          -  history of unexplained dyspnea on exertion of > 3 months

          -  exhibits coughing and bilateral, basilar, inspiratory crackles on physical exam

          -  presents as being in a stable phase of IPF

          -  lung biopsy or HRCT indicative of IPF

        Exclusion Criteria:

          -  ACE inhibitor use

          -  GERD

          -  current cancer or history of lung cancer

          -  non-ambulatory

          -  hospitalized in the previous 12 months for heart failure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Entailment
Clinical trial: Safety and Efficacy of Lansoprazole in Patients With Reflux Disease (NCT01135368)

Eligibility criteria:
Inclusion Criteria:

          -  Had Gastro Esophageal Reflux disease with or without oesophagitis.

          -  Had a history of heartburn at least for 5 days per week during the past 6 months or
             was receiving long-term treatment with a proton pump inhibitor and during two weeks
             (without proton pump inhibitor treatment) prior to enrolment.

        Exclusion Criteria:

          -  History of surgery of stomach or oesophagus.

          -  Gastric ulcer (can be included after healing of gastric ulcer).

          -  Duodenal ulcer (can be included after healing of duodenal ulcer).

          -  Bleeding (melena, hematemesis).

          -  Severe concomitant disease (cancer, cardiovascular, renal, hepatic diseases).

          -  Barrett oesophagus with dysplasia.

          -  Complicated esophagitis (oesophageal strictures or ulcers).

          -  Treatment with proton pump inhibitor or Histamine receptor 2 (H2)antagonists within
             the previous two weeks.

          -  Pregnancy, wish to become pregnant, breast feeding.

          -  Treatment with non steroidal anti-inflammatory drugs, treatment with acetylsalicylic
             acid (aspirin) > 100 mg/day.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Extension Study of Pegylated Somatropin to Treat Growth Retardation Caused by Endogenous Growth Hormone Deficiency in Children (NCT03290235)

Eligibility criteria:
Inclusion Criteria:

          -  Children has completed all visits and therapy in previous phase IV study;

          -  Investigators evaluate subjects could continue growth hormone therapy;

          -  Subjects is willing and able to cooperate to complete scheduled visits, treatment
             plans and laboratory tests and other procedures, to sign informed consent.

        Exclusion Criteria:

          -  Children with epiphyseal closure;

          -  Children is near the adule final height, that is, growth rate≤ 2 cm / year or bone age
             ≥ 14 years old for girls, bone age ≥ 16 years old for boys;

          -  Dysfunction of liver and kidney (ALT> 2 times the upper limit of normal, Cr> upper
             limit of normal);

          -  Patients with known hypersensitivity to PEG-Somatropin or Somatropin or any other
             components of the study product;

          -  Patients with severe cardiopulmonary or hematological diseases, a current or past
             history of malignant tumors, immunodeficiency diseases, or mental diseases;

          -  Patients with diabetics;

          -  Patients with congenital bone dysplasia or scoliosis;

          -  Patients took drugs that would influence the efficacy and safety of PEG-Somatropin
             after phase IV study and before screening for this extension study;

          -  Other conditions in which the investigator preclude enrollment into the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 42 Months old.
Subject must be at most 15 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer (NCT03030404)

Eligibility criteria:
-INCLUSION CRITERIA:

          1. An individual, or their family members, with any of the following:

               -  Fulfills clinical criteria for Hereditary Diffuse Gastric Cancer (HGDC) syndrome
                  or Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) syndrome

               -  Clinically suspicious personal or family medical history of gastric cancer or
                  gastric cancer syndrome that warrants genetics evaluation

               -  Current diagnosis of gastric cancer and a germline mutation associated with a
                  known cancer syndrome or an associated family history of gastric cancer

               -  Harbors a pathogenic germline mutation known to predispose to gastric cancer

               -  First-degree relatives, regardless of family history or personal history of
                  cancer, with a documented deleterious germline mutation (including but not
                  limited to CDH1, CTNNA1, SDH) known to predispose to gastric tumors

               -  Diagnosis or suspicion of a premalignant or malignant stomach lesion of suspected
                  hereditary etiology

          2. Age greater than or equal to 18 years; patients under 18 years of age and greater than
             or equal to the age of 2 may participate if the tissue acquisition is performed during
             a clinically indicated surgical procedure, and the sampling of tissue, blood and urine
             collection does not add risk to the clinically indicated procedures.

          3. Ability of subject or legally authorized representative (LAR) to understand and the
             willingness to sign a written informed consent document.

        EXCLUSION CRITERIA:

        -None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 2 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Sensory Memory in Speech Motor Learning (NCT04818268)

Eligibility criteria:
Inclusion Criteria:

          -  right handed adults

          -  no known physical or neurological abnormalities

        Exclusion Criteria:

          -  patients with:

          -  cardiac pacemaker

          -  surgical clips or values on the heart

          -  implants

          -  metal or metallic fragments in any part of the body

          -  pregnancy

          -  claustrophobia

          -  a personal or family history of epilepsy

          -  currently taking antipsychotic drugs

          -  currently taking antidepressant drugs

          -  currently taking antianxiety drugs

          -  history of concussion.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Thrombosis and Covid-19 (NCT04366778)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Covid-19

          -  non-opposition of the patient to participate

        Exclusion Criteria:

          -  Non-Covid-19 acute respiratory distress syndrome

          -  Non-Covid septicemia

          -  Pregnant women

          -  Breastfeeding women

          -  Protected vulnerable adults
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction