araag2/NLI4PR huggingface dataset:
Clinical trial: Study Evaluating A Novel Ibuprofen Formulation In The Treatment Of Dental Pain (NCT01216163)

Eligibility criteria:
Inclusion Criteria:

          -  Normal, healthy males and females 16 to 40 years of age

          -  Outpatients who have moderate to severe post-operative pain (confirmed by a Visual
             Analog Scale-Pain Severity Rating [VAS-PSR] score of at least 50 mm on a 100 mm VAS
             PSR) following surgical extraction of two or more third molars, at least one of which
             must be a partial or complete bony mandibular impaction

          -  Use of only the following pre-operative medication(s)/anesthetic(s): topical
             benzocaine, a short acting parenteral (local) anesthetic (mepivacaine or lidocaine)
             with or without vasoconstrictor and/or nitrous oxide

        Exclusion Criteria:

          -  Pregnancy or breast-feeding

          -  Alcohol or substance abuse

          -  Any serious medical or psychiatric disorder

          -  History of stomach ulcers, stomach bleed, or other bleeding disorders

          -  Use of a prescription or over-the-counter (OTC) drug with which administration of
             ibuprofen or any other non-steroidal anti-inflammatory drug (NSAID); acetaminophen
             (APAP); or codeine or any other opioid is contraindicated (including: opioids,
             antipsychotics, antianxiety agents, or other central nervous system depressants
             [including alcohol])
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Popular Diets Study (NCT00315354)

Eligibility criteria:
Inclusion Criteria:

          -  BMI ≥ 27 kg/m2

          -  Willing and able to come to the GCRC 5 days per week to consume a supervised meal and
             pick-up food for all other meals

          -  Available for scheduled hospital admissions

          -  Willing to abstain from alcohol consumption for the duration of the study

          -  If female, regular menstrual cycles (defined as 26 to 30 days between cycles; no more
             than one day variation in the duration of menstrual flow)

        Exclusion Criteria:

          -  Weight > 350 lbs

          -  Change in body weight (± 10%) over preceding year

          -  Taking any medications or dietary supplements that might affect body weight, appetite,
             or energy expenditure

          -  Smoking (1 cigarette in the last week)

          -  High levels of physical activity

          -  Currently following a special diet

          -  Abnormal laboratory screening tests

          -  Type 2 diabetes mellitus

          -  Allergies or aversions to foods on the study menu

          -  Previous diagnosis of an eating disorder or any other mental health disorder

          -  If female, pregnant in the past 12 months or planning to become pregnant during the
             study period

          -  If female, lactating in the preceding 12 months

          -  If taking birth control medication, change in medication in previous 3 months or plans
             to change medication during the study period
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Adrenal Venous Sampling in Patients With Overt or Subclinical Cushings Syndrome, and Bilateral Adrenal Tumors (NCT02543697)

Eligibility criteria:
Inclusion Criteria:

          -  Benign tumors/adenomas in the adrenals and biochemically overproduction of cortisol

        Exclusion Criteria:

          -  Use of steroids ( tablets, inhalations, lotions)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Contradiction
Clinical trial: Assessing the Role of the NLRP3 Inflammasome in Intercritical Gout (NCT04125459)

Eligibility criteria:
Inclusion Criteria:

          1. Adult patients with gout diagnosed by a Rheumatologist.

          2. patients with a history of at least two gout attacks in the target joint

          3. Patients with a target joint amenable to biopsy. Target joint defined as:

        Joint that has been affected by acute gout attack at least twice in the 12 months prior to
        enrollment.

        Ultrasound finds grade 2 gray-scale synovitis in joint. Joint is amenable to biopsy. At the
        time of enrollment, the joint is without signs of acute inflammation: redness, swelling,
        and severe pain (>7/10).

        Exclusion Criteria:

          1. Patients on anti-coagulation therapy.

          2. Patients with an active infection.

          3. Tophus present at the biopsy site.

          4. Target joint with signs of acute gout attack (pain >7/10, redness, warmth)

          5. Known chondrocalcinosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Use of Human Fibrin Glue Versus Staples for Mesh Fixation in Laparoscopic Transabdominal Preperitoneal Hernioplasty (NCT01641718)

Eligibility criteria:
Inclusion Criteria:

          -  primary hernia repair (no re-operation for recurrent hernia)

          -  good compliance can be expected

          -  informed consent

        Exclusion Criteria:

          -  chronic pain

          -  acute pain requiring analgesic others than paracetamol or more than a single dose
             non-steroidal anti-inflammatory drugs treatment within 48 h before surgery

          -  current treatment with psychopharmaceutical drugs

          -  mental incapacity

          -  known incompatibility (allergies) with the Tisseel compounds
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Echocardiography-guided Transthoracic Radio Frequency/Laser Ablation for Ventricular Septum of Hypertrophic Obstructive Cardiomyopathy (NCT02888132)

Eligibility criteria:
Inclusion Criteria:

          -  Subject who cannot tolerate ventricular septum resection or transcatheter ethanol
             ablation and volunteer for the operation

          -  Subject meets HOCM diagnosis standards verified by the echocardiogram; the obstruction
             is located in the basal part of ventricular septum

          -  Subject has significant clinical symptoms, including progressively increasing fatigue,
             angina, exertional dyspnea, and syncope; subject receives poor effect after drug
             therapy or cannot tolerate side effects of medication

          -  Subject has pressure gradient of left ventricular outflow tract (LVOT) ≥50 mmHg（with
             Systolic Anterior Motion）in the resting-state or after exercise stress test

          -  Subject over 18 years old

        Exclusion Criteria:

          -  Subject has non-obstructive hypertrophic cardiomyopathy

          -  Subject has combined cerebral vascular diseases

          -  Subject has diseases that must receive surgeries, including severe mitral valve
             lesions and coronary heart disease which requires coronary artery bypass grafting.

          -  Subject has end-stage heart failure

          -  Subject has intraventricular septal thickness (IVST) ≥ 30mm
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of the Efficiency of Two Different PPI Formula in Atypical GERD (NCT03418337)

Eligibility criteria:
Inclusion Criteria:

          1. atypical GERD symptoms (cough, globus, or NCCP)

          2. with or without typical GERD symptoms (heartburn or acid regurgitation)

          3. A total Reflux Symptom Index (RSI) score ≥13

        Exclusion Criteria:

          1. Patients who currently took pro-kinetic agents, baclofen, antacid, sucralfate,
             histamin-2 receptor antagonists, PPI, antitussive, non-steroid anti-inflammatory
             drugs, anxiolytics, or anti-depressants during screening and during study period

          2. Patients who have severe cardiac, pulmonary, hepatic, or renal diseases

          3. Patients who have uncured underlying malignancy

          4. Patients with laryngeal or pharyngeal disorders

          5. Patients with a history of gastrointestinal (GI) surgery, symptoms of GI tract
             obstruction

          6. Patients with a contraindication for PPI use
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies (NCT03811964)

Eligibility criteria:
Inclusion Criteria:

          -  Man or woman

          -  Aged 18 years or older

          -  Subject having signed a free and informed consent

          -  Subject affiliated to a social protection scheme Arm 1 :Subjects with primary
             sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder
             of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric
             pathology pathology with disorder of the controls of the wake and the sleep Arm 4 :
             subject presenting an ophthalmological pathology with possible alteration of the
             photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with
             regulation disorder of sleep and wake Arm 6 : healthy subject

        Exclusion Criteria:

        Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa,
        macular involvement of diabetes)

          -  Cataract with significant vision loss <5/10

          -  Chorioretinal neovascularization

          -  Subject in exclusion period determined by previous or current study

          -  Impossibility to give the subject information enlightened (subject in emergency
             situation, difficulties of understanding the subject, ...)

          -  Subject under the protection of justice

          -  Subject under guardianship or curatorship

          -  Pregnancy / Breastfeeding
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient description (patient's own words): I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Does the patient match the trial criteria? Entailment
Clinical trial: Short Segment Fixation in Thoracolumbar Osteoporotic Fracture (NCT02719340)

Eligibility criteria:
Inclusion Criteria

          -  osteoporotic burst fracture at a single level of the thoracolumbar region

          -  dual-energy X-ray absorptiometry and T-score value less than -2.5

        Exclusion Criteria

          -  translational displacement at the fracture site (fracture-dislocation)

          -  loss of structural integrity within the posterior osteoligamentous complex (such as
             flexion-distraction ligament disruption)

          -  spondylolisthesis of the adjacent vertebrae

          -  malignancy

          -  chronic steroid administration

          -  previous spinal surgery

          -  prior vertebroplasty and infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction