araag2/NLI4PR huggingface dataset:
Clinical trial: Efficacy and Safety Study Comparing CD07805/47 Gel 0.5% to Azelaic Acid Gel 15% in Subjects With Erythema of Rosacea (NCT01659853)

Eligibility criteria:
Inclusion Criteria:

          1. Subject is male or female aged 18 years or older.

          2. Subject has a clinical diagnosis of facial rosacea.

          3. Subject has a clinician's assessment score of moderate to severe erythema prior to
             enrollment.

          4. Subject has a self assessment score of moderate to severe redness prior to enrollment.

          5. Subjects with none to mild facial inflammatory lesions of rosacea prior to enrollment.

        Exclusion Criteria:

          1. Female subjects who are pregnant, nursing or planning a pregnancy during the study.

          2. Subjects with a condition or who are in a situation, which in the Investigator's
             opinion may put a subject at risk, may confound study results, or may interfere with a
             subject's participation in the study.

          3. Subjects with conditions causing facial erythema which would confound the assessment
             of treatment.

          4. Subjects who are taking or have recently taken medications known to have interactions
             with α2-adrenergic agonists.

          5. Subjects with known allergies or sensitivities to one of the components of the
             investigational products.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of Positional Therapy on Symptoms of Gastroesophageal Reflux Disease: A Prospective Pilot Study (NCT04500288)

Eligibility criteria:
Inclusion Criteria:

          1. Patients over the age of 18 who have proven GERD (with nighttime heartburn at least 3
             days a week).

          2. Agree to undergo sleep positioning therapy.

          3. Able to read, understand, and complete study questionnaires.

          4. Have mobile phones with an operating system (Android or iOS) that supports the LEFT
             device.

        Exclusion Criteria:

        1. Patients who are under the age of 18.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Translational Investigation of Growth and Everyday Routines in Kids (TIGER Kids) Fitness Ancillary (NCT03611296)

Eligibility criteria:
Inclusion Criteria:

          -  Eligible for the TIGER Kids primary study

          -  BMI >/= 85th percentile

          -  Height >/= 4 feet 6 inches

          -  Weight < 350 pounds

        Exclusion Criteria:

          -  Anemia

          -  American College of Sports Medicine (ACSM) contraindications to exercise testing
             (i.e., medical history of cardiovascular or pulmonary conditions, physical conditions
             that affect the ability to exercise)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 16 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Survivin as Predictive Biomarker for RA (NCT03444623)

Eligibility criteria:
Inclusion Criteria:

          -  Patients seeking treatment at the primary health care for problems with their joints
             (pain, stiffness).

        Exclusion Criteria:

          -  Patients diagnosed with RA
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Role of Chest Sonography in Evaluation of Pleurodesis in Patients With Malignant Pleural Effusion (NCT04074902)

Eligibility criteria:
Inclusion Criteria:

          -  Any patient with malignant pleural effusion who will undergo palliative treatment with
             insertion of intercostal tube.

        Exclusion Criteria:

          1. Patients <18 years old, unable to provide informed consent.

          2. Had an allergy or other contraindication to intrapleural pleurodesis.

          3. Had evidence of unexpandable lung believed by the responsible clinician to represent
             insufficient.

          4. pleural apposition that would preclude pleurodesis, and/or had an expected survival
             of<1 month.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of MRI Monitoring in Patients With Aplastic Anemia and Low or Int-1 Risk of MDS Complicated With Iron Overload (NCT02833493)

Eligibility criteria:
Inclusion Criteria:

          1. Male or female of 18-80 year old.

          2. With blood transfusion history or RBC-transfusion-dependence.

          3. BM smear and biopsy plus chromosome analysis within 3 months before signing ICF,
             otherwise done during screening.

          4. Excluding other diseases which might cause hematological abnormalities.

          5. Serum ferritin level≥500ng/ml with no sign of active infection or malignant disease.

          6. Treatment with underlying disease is permitted for non-hematological and hematological
             conditions.

          7. Previous iron chelation therapy like deferasirox or deferoxamine is permitted.

          8. ECOG performance score ≤2

          9. All subjects must: agree not to donate blood or be counseled about pregnancy
             precautions and risks of fetal exposure.

         10. Written informed consent.

        Exclusion Criteria:

          1. Patients who are under 18-year-old or over 80-year-old.

          2. Prior history of other cancer unless cancer-free for ≥5 years.

             Subjects with the following history/concurrent conditions may enroll at any time:

             Basal cell carcinoma of the skin Squamous cell carcinoma of the skin Prostate cancer
             stage-1

          3. Proved HIV-1 infection

          4. Active HBV or active HCV infection.

          5. Pregnant or lactating

          6. Patients unwilling to or unable to comply with the protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Physical Activity With Tailored E-health Support for Individuals With Intellectual Disability (NCT04079439)

Eligibility criteria:
Inclusion Criteria:

          -  Intellectual disability

          -  Age 15-60 years

          -  Low physical activity

          -  Sedentary lifestyle

        Exclusion Criteria:

          -  Medical contradictions for participation

          -  High levels of physical activity
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Helpfulness of the Vibration Test Performed in Room Light on Clients With Inner Ear Problems (NCT02626052)

Eligibility criteria:
Inclusion Criteria:

          -  Clients 18 years and older with complaint of dizziness, vertigo, and/or imbalance who
             are willing to proceed with procedures of study.

          -  Inclusion for control group: no history of dizziness, vertigo, and/or imbalance.

        Exclusion Criteria:

          -  Conditions that warrant immediate referral to the Emergency Department or Primary Care
             Physician (undiagnosed and unstable disorders relating to cardiac, neurologic,
             metabolic, etc, dysfunction); no history of dizziness, vertigo, and/or balance
             problems.

          -  Clients with conditions that therapists believe may be aggravated by testing
             including, but not limited to: variants of head injuries, migraines, seizure
             disorders, panic/anxiety, claustrophobia, severe headache and/or nausea, and
             hypersensitivity to sensory stimuli
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment
Clinical trial: Treatment of Adrenal Insufficiency in Children (NCT02720952)

Eligibility criteria:
Inclusion Criteria:

          1. Male and female children less than 6 years of age.

          2. A diagnosis of adrenal insufficiency as confirmed by an inappropriately low cortisol
             usually with other supporting tests.

          3. Receiving appropriate adrenocortical replacement therapy (hydrocortisone with/without
             fludrocortisone).

          4. Adequately hydrated and nourished.

          5. Ability of parents/carers to understand and give written Informed Consent

        Exclusion Criteria:

          1. Clinically evident acute adrenal insufficiency (adrenal crisis).

          2. Inability of the child to take oral therapy.

          3. Concomitant therapy (other than that required to treat adrenal insufficiency, Vitamin
             D, Fluoride, Thyroxine and growth hormone).

          4. Subjects with clinical signs of acute infection or fever on Day 1.

          5. Any surgical or medical condition which in the opinion of the investigator may place
             the subject at higher risk from his/her participation in the study.

          6. Parents/carers of subjects unwilling to consent to saving and propagation of
             pseudonymised medical data for study reasons.

          7. Subjects who are dependent on the investigator or the sponsor.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 6 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of a New MR Pulse Sequence to Quantify Liver Iron Concentration (NCT00587535)

Eligibility criteria:
Inclusion Criteria:

          -  Undergoing liver biopsy for suspected or known hemochromatosis

          -  Undergoing liver biopsy for living-related liver donation evaluation

        Exclusion Criteria:

          -  Contraindication to MRI
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction