araag2/NLI4PR huggingface dataset:
Clinical trial: Effect of Intrauterine Injection of HCG on Clinical Pregnancy Outcome in Repeated Implantation Failure Patients (NCT03682614)

Eligibility criteria:
Inclusion Criteria:

          -  repeated implantation failure patients: ≥ 3 times IVF-embryo transfer failed to help
             pregnancy (biochemical or non-pregnant)

          -  age ≤36 years old

          -  normal histopathological stage (+5-7)

          -  endometrial NK cell <4.5%

          -  0 endometrial CD138 positive cell

          -  natural cycle frozen embryo transfer

          -  frozen blastocysts (≥4BC) embryos ≥ 1

        Exclusion Criteria:

          -  Scar uterus (diverticulum or incision false lumen after cesarean section)

          -  intrauterine adhesions

          -  untreated hydrosalpinx

          -  adenomyosis (endometrial displacement)

          -  endometritis

          -  uterine fibroids compress the endometrium
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 36 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study to Evaluate the Long-term Safety of a Once-Daily Omiganan Topical Gel (NCT02576847)

Eligibility criteria:
Inclusion Criteria:

          1. Healthy, male and nonpregnant female subjects, 18 years of age or older.

          2. A diagnosis of severe papulopustular rosacea using the Investigator Global Assessment
             grading scale at baseline

          3. Subjects with the presence of telangiectasia at Baseline

          4. Subjects with the presence of facial erythema associated with their rosacea at
             Baseline

        Exclusion Criteria:

          1. Subjects with steroid rosacea or subtype 3 (phymatous rosacea).

          2. Subjects with nodular rosacea

          3. Standard exclusion criteria.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Treatment of Post-Extraction Dehisced Socket - A Case Series Study (NCT02980211)

Eligibility criteria:
INCLUSION CRITERIA

          -  Provision of informed consent

          -  Age: 18 years or older

          -  Subjects with a single-rooted tooth indicated for extraction bounded by stable,
             natural teeth

          -  Tooth planned for extraction must have a dehiscence defect in the surrounding bone,
             observed clinically and/or radiographically, that affects at least 50% of the bone
             height

          -  Subjects must be interested in replacing the tooth with a single implant-supported
             fixed restoration

          -  Subjects must be able and willing to follow instructions related to the study
             procedures

          -  Subjects must have read, understood and signed an informed consent form

        EXCLUSION CRITERIA

          -  Mandibular incisors

          -  Subjects with a history of organ failure (e.g. liver, kidney)

          -  Subjects with severe hematologic disorders, such as hemophilia or leukemia

          -  Subjects with uncontrolled and/or severe metabolic bone diseases or disorders, such as
             osteoporosis, thyroid disorders or Paget's disease

          -  Subjects taking any medication or supplement known to largely influence bone
             metabolism, such as IV bisphosphonates, long-term history of oral bisphosphonates or
             chronic intake of glucocorticoids

          -  Pregnant women (as indicated by positive serum HCG test) or nursing mothers

          -  Subjects with conditions that would result in compromised healing (e.g. poorly
             controlled diabetes, active heavy tobacco use [>10 cigs/day])

          -  Subjects who, at the discretion of the investigators, would be unsuitable candidates
             for the study due to safety, psychological or practical reasons (e.g. known allergies
             to any product used for the study, limited mouth opening, etc.)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Resistance Training and Sex Hormone Concentrations During the Menstrual Cycle (NCT04163380)

Eligibility criteria:
Inclusion Criteria:

          -  Eumenorrheic females

          -  Age 18-45 years old

          -  BMI of 18.5-34.99 kg/m2

        Exclusion Criteria:

          -  Practice exercise more than 2 days/week in the last 3 months.

          -  Cardiovascular, metabolic, pulmonary or muscular-skeletal condition

          -  Taking medications that affect metabolism (e.g. oral contraceptives)

          -  Irregular menstrual cycles
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: An Efficacy and Safety Study of Acetaminophen Plus Tramadol Hydrochloride (JNS013) in Participants With Chronic Pain (NCT00736853)

Eligibility criteria:
Inclusion Criteria:

          -  Participants with sustention of chronic pain associated with OA or LBP for at least 3
             months

          -  Participants whose pain cannot be controlled sufficiently with at least 14-day
             continuous treatment with identical oral NSAIDs at a usual maximum dose during 3
             months prior to this study

          -  Outpatients

          -  Ambulatory participants without need for any supportive device or assistance during
             daily life

        Exclusion Criteria:

          -  Participants with conditions for which opioids are contraindicated

          -  Participants with conditions for which acetaminophen is contraindicated

          -  Participants with history of convulsion or the possibility of convulsive seizure

          -  Participants with concurrent, previous, or possible alcohol dependence, drug
             dependence, or narcotic addiction

          -  Pregnant participants or those who may be pregnant, lactating mothers, and
             participants who wish pregnancy during the study period
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Clinical Trial of Creatine in Amyotrophic Lateral Sclerosis [ALS] (NCT00005674)

Eligibility criteria:
Inclusion Criteria:

          -  A clinical diagnosis of definite, probably or laboratory supported probably ALS,
             either sporadic or familial ALS according to a modified El Escorial criteria

          -  Willing and able to give informed consent

          -  FVC greater than or equal to 50% predicted

          -  Evidence of abnormality in upper and/or lower extremity motor function (clinical
             evidence of muscle atrophy and weakness in an upper and/or lower extremity). The
             patient should have at least 4 or 8 testable upper extremity muscle groups.

          -  Subjects may take riluzole. Riluzole must have been at stable doses for at least
             thirty days prior to baseline visit.

          -  If woman of childbearing age, must be non-lactating and surgically sterile or using an
             effective method of birth control (double barrier or oral contraceptive) and have a
             negative pregnancy test

          -  Disease duration less than five years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Use of Platelet Indices for Prediction of Recurrent Miscarriage (NCT03710226)

Eligibility criteria:
Inclusion Criteria:

          1. Women aged 18-49 years.

          2. Women with history of recurrent miscarriage(two or more consecutive miscarriages)

          3. Women with history of previous deliveries.

        Exclusion Criteria:

          1. Pregnant women

          2. Women with medical disease (e.g. DM, thyroid disorders, hypertension, systemic lupus
             erythematosus, antiphospholipid antibody syndrome).

          3. Women with known uterine anomalies.

          4. Obesity (BMI >30%).

          5. Women on anticoagulant medications or antiplatelet medications.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 49 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Validation of the JADE wRAP™, a Novel Blood Pressure Measurement Device, Using the Same Arm Sequential Method (NCT03452280)

Eligibility criteria:
Inclusion Criteria:

          1. Must be at least 18 years of age

          2. Male or Female

          3. Must provide written informed consent prior to the performance of any study-related
             procedures.

        Exclusion Criteria:

          1. Subjects who in the opinion of the study staff are too agitated, distressed or who are
             otherwise unable to cooperate with study procedures

          2. Subjects with bigeminy, trigeminy, isolated ventricular premature beat (VPD) or atrial
             fibrillation or any other condition, in the opinion of the study staff that can result
             in a significantly irregular heath rhythm.

          3. Subjects with signs or recent history of inflammation or infection of the wrists or at
             the reference clinical test site.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Application of a Systematic Developmental Assessment to a Novel Population: Infants With Rare Genetic Disorders (NCT03967743)

Eligibility criteria:
Inclusion Criteria:

          -  Eligible patients are infants under 4 years of age with genetic disorders undergoing
             developmental surveillance in the NICU GraDS program.

        Exclusion Criteria:

          -  Children 4 years of age or older will be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 4 Years

Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? Entailment
Clinical trial: Mass Drug Administrations of DHA-PQP to Accelerate Towards Malaria Elimination in Magude District, Southern Mozambique (NCT02914145)

Eligibility criteria:
Inclusion Criteria:

          -  Individuals who consent to participate in the study

          -  Residents in the study area

          -  Older than 6 months of age (or weighing more than 5Kg)

          -  Women in the second or third trimester who are not on IPTp

        Exclusion Criteria:

          -  Individuals who do not consent to participate in the study

          -  Younger than 6 months of age (or weighing more than 5Kg)

          -  Women in the first trimester of pregnancy

          -  Severely ill individuals

          -  Individuals on contra-indicated medication
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment