araag2/NLI4PR huggingface dataset:
Clinical trial: Family SuppleMented pAtient monitoRing afTEr suRgery: A Pilot Trial (NCT04341558)

Eligibility criteria:
Inclusion Criteria:

        Patients:

        • Patients ≥5 years of age undergoing surgery at Mbale Regional Referral Hospital, who
        receive post-operative care in one of four main surgical wards, with a family carer
        prepared to participate in the trial intervention.

        Carers:

          -  All carers will be included in the trial if they feel they are capable of performing
             and documenting the basic vital signs provided they agree to participate in the trial.

          -  The ability to speak English, Luganda, Lugisu, Ateso or Lugwere

          -  The ability to read a digital clock (to measure vital signs)

          -  Numeracy sufficient to write numbers on the basic observation chart

        Exclusion Criteria:

        Patients:

          -  Refusal of informed consent.

          -  Identification of potential participant >24hours after operative procedure has taken
             place

        Carers:

        • Refusal of informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.


Patient description (medical language): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient description (patient's own words): I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Does the patient match the trial criteria? Entailment
Clinical trial: BFRT for Severe Lower Extremity Muscle Atrophy (NCT04357184)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with > 20% deficit in isometric quadriceps and/or hamstrings strength

          -  Patients willing to complete at least 9 BFRT training sessions

          -  Patients willing to provide informed consent (or parental consent)

        Exclusion Criteria:

          -  Pregnancy

          -  History of varicose veins

          -  History of blood clots or active blood clot

          -  Taking oral contraceptives

          -  History of heart attack

          -  Unstable cardiac disease

          -  Taking heart failure medication

          -  Uncontrolled hypertension (> 140/90)

          -  Uncontrolled tachycardia (> 100 bpm)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Clinical Protocol of Sensitized Acupoint Changes in Knee Osteoarthritis Patients (NCT03599180)

Eligibility criteria:
Inclusion Criteria:

        Meets the diagnosis criteria of knee osteoarthritis. Age between 45 and 70 years. Meets
        imaging examination X-ray Kellgren and Laerence classification standards grade I-III.

        Patients who meet the criteria for early or mid-term stage of knee osteoarthritis.

        Discontinue use of pain medications and hormone drugs during the trial. The patient's vital
        signs are stable, can read his own medical history, and can cooperate with the relevant
        examination and treatment.

        Signed the informed consent voluntarily.

        Exclusion Criteria:

        Seriously patients with surgical indications Associated systemic arthropathies, e.g.
        rheumatoid arthritis and gout Heart failure Bleeding diathesis Liver failure knee
        arthroplasty There are diseases that may seriously endanger life, such as cardiovascular
        and cerebrovascular diseases, renal and liver failure, hematopoietic system diseases, etc.

        Patients with mental illnesses that cannot be completed or are not suitable for treatment
        and examination Patients who received treatment including traditional Chinese medicine,
        western medicine, acupuncture, massage and physiotherapy within the past month Patients on
        steroids History of intra articular injection of steroid within last six months Joint
        irrigation or arthroscopy has been performed within the past year Have had knee
        arthroplasty At the same time participate in other studies
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 38 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Timing of Umbilical Cord Clamping on Haematological and Clinical Outcomes of Infants (NCT01081977)

Eligibility criteria:
Inclusion Criteria:

          -  Mother-infant pairs, between 35 weeks and 41 completed weeks of pregnancy, planned to
             deliver through vaginal or Elective lower segment cesarean section(ELSCS)

        Exclusion Criteria:

          -  Women with multiple gestation

          -  Complications like pregnancy induced hypertension (PIH), Gestational diabetes Mellitus
             (GDM), Pre/Eclampsia, placental insufficiency, suboptimal CTG (late deceleration,
             variable deceleration)

          -  Rh-isoimmunization

          -  Chronic maternal illnesses (hypertension, cardiomyopathies, chronic renal diseases,
             haemoglobinopathies

          -  Pre-existing risk factor for postpartum haemorrhage, like polyhydramnios, previous PPH

          -  Infants with antenatal diagnosis of congenital malformations of any system (CVS, GIT,
             RENAL CNS ,RESP), anomalies or syndromes

          -  Emergency caesarean section (EmLSCS)

          -  Need for neonatal resuscitation at birth and NICU admission due to causes not directly
             related to the intervention trial.

        Criteria 1 to 6 will be applied before randomization and criteria 7 and 8 assess after
        randomization.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers

Subject must be at most 3 Months

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Influence of the Sound Generator Combined With Conventional Amplification for Tinnitus Control: Blind Randomized Clinical Trial (NCT01857661)

Eligibility criteria:
Inclusion Criteria:

          -  mild to moderate sensorineural hearing loss

          -  tinnitus (THI > 20)

          -  first user

        Exclusion Criteria:

          -  profound hearing loss

          -  conductive hearing loss

          -  THI < 20
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Red Meat Intake on Occurrence of Serum Non-transferrin Bound Iron (NTBI) (NCT03019393)

Eligibility criteria:
Inclusion Criteria:

          -  Apparently healthy male volunteers (21 - 45 years old)

          -  C-reactive protein (CRP) < 5 mg/L

        Exclusion Criteria:

          -  Blood donation or significant blood loss (e.g. surgery) within the past 4 months

          -  Regular intake of iron and other nutrient supplements within the past 4 months

          -  Regular intake of medication except oral contraceptives

          -  Acute or recent inflammatory or infectious symptoms

          -  Chronic gastrointestinal disorders or metabolic diseases

          -  Smoking

          -  Coeliac disease or gluten-related disorders

          -  Iron deficiency anemia (Hb < 14 g/dL for males) with serum ferritin concentration < 30
             ng/mL)

          -  Non-iron deficiency anemia (serum ferritin concentration within normal range (30 - 300
             ng/mL for males) but low hemoglobin (< 14 g/dL for males)

          -  Iron overload conditions (serum ferritin concentration > 300 ng/mL for males)

          -  Known hereditary disorders of iron metabolism
Male
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients (NCT03326622)

Eligibility criteria:
Inclusion Criteria:

          -  Consecutive patients diagnosed with definite, probable, or probable laboratory
             supported ALS

          -  Disease duration from first symptoms between 6-24 months to exclude slow and fast
             progression

          -  ALSFRS-R ≥ 30

          -  FVC (%predicted) ≥ 70%

        Exclusion Criteria:

          -  Other medical conditions, like cardiac insufficiency and lung disorders or others
             conditions limiting exercise training;

          -  Heavy smoking habits with laboratorial evidence of significant bronchial constriction;

          -  Signs of associated dementia or psychiatric disorders.

        Note: None of the patients were on tube feeding, invasive or non-invasive mechanical
        ventilation at admission of study protocol (T1).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Study Protocol for CTS and Keyboard Controlled Randomized Trial (NCT02101294)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of carpal tunnel syndrome

          -  Completion of a nerve conduction velocity study (NCVS) within the past twelve months
             or a physician waiver of the NCVS

          -  Able to type using all fingers on the keyboard

        Exclusion Criteria:

          -  Do not use all of their fingers when typing

          -  No active symptoms of carpal tunnel syndrome

          -  Unable to type, or flex and extend the fingers, for whatever reason

          -  Unable or unwilling to provide informed consent

          -  Use of pain relievers or medications during study sessions (potentially masking
             symptoms of median nerve entrapment)

          -  Unable to complete the typing activities before their symptoms (swelling associated
             with body ailments or metabolism) changed

          -  Had inconsistent subjective and objective evaluations in the preactivity test

          -  Threaten or abuse the investigator

          -  Unable to perform the activity so as to meet the minimal use requirements

          -  Had such injury as they had no sensation in their hands (i.e. Late stage)

          -  May suffer further injury (as indicated by their medical history) by attempting the
             typing activity

          -  Had non CTS related metabolic problems and upper extremity neurologic conditions,
             current or past, which have similar symptoms to median nerve entrapment, but which
             were not due to median nerve entrapment in the carpal canal
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effectiveness of Microcurrent for Treatment of Tennis Elbow (NCT00817232)

Eligibility criteria:
Inclusion Criteria:

          -  symptoms of tennis elbow for at least 3 months

          -  clinical diagnosis of tennis elbow

        Exclusion Criteria:

          -  significant symptom improvement in previous month

          -  receipt of any active treatment for the condition in the previous month

          -  currently under the care of another health professional for tennis elbow

          -  current cervical radiculopathy

          -  other pathology affecting distal upper limb
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction