araag2/NLI4PR huggingface dataset:
Clinical trial: Yinhu Qingwen Decoction for the Treatment of Mild / Common CoVID-19 (NCT04278963)

Eligibility criteria:
Inclusion Criteria:

          1. Age ≥18 years at time of signing Informed Consent Form.

          2. Laboratory (RT-PCR) confirmed infection with CoVID-19.

          3. Hospitalised with Fever(≥36.7℃ -axilla or oral temperature ≥ 38.0 ℃ or ≥38.6°C
             tympanic or rectal) and cough;

          4. No difficulty swallowing oral medications.

          5. Must agree not to enroll in another study of an investigational agent prior to
             completion of Day 28 of study.

        Exclusion Criteria:

          1. Allergies, known to be allergic to research drugs or drug excipients;

          2. Patient weight is less than 40 kg;

          3. Respiratory distress-RR≥30 / min on room air,or SPO2≤ 93%, or PaO2/FiO2 ≤300mmHg
             (1mmHg = 0.133kPa)

          4. Shock;

          5. The clinician judges that ICU monitoring treatment is needed;

          6. Patients who have participated in other clinical trials within 1 month;

          7. Known patients with impaired renal function (estimated creatinine clearance <60 mL /
             min (male: Cr (ml / min) = (140-age) × body weight (kg) / 72 × blood creatinine
             concentration (mg / dl); female: Cr (ml / min) = (140-age) × weight (kg) / 85 × blood
             creatinine concentration (mg / dl));

          8. During the screening or within 24 hours before screening, patients were found to have
             any of the following laboratory parameter abnormalities (based on local laboratory
             reference range):-ALT or AST level> 5 times the upper limit of normal range (ULN)
             or-ALT or AST > 3 times ULN and total bilirubin levels> 2 times ULN;

          9. Being pregnant or breastfeeding, or having a positive pregnancy test at the time of
             pre-dose inspection, or planning to become pregnant within 3 months of study
             treatment.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: ALzheimer and MUsic THerapy: Effects of Music Lessons on Brain Plasticity, Mood, and Quality of Life in Alzheimer Patients (NCT03444181)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Alzheimer Disease

          -  Living independently at home (not in a care home or similar aged care facility)

          -  Able to complete questionnaires in Norwegian

          -  Able to undergo MRI scans

          -  Able to attend interventions and assessments in the area of Bergen, Norway

          -  Has given informed consent

        Exclusion Criteria:

          -  Hearing impairment that cannot be mended by hearing aids

          -  Conditions that hinder MRI scans, such as claustrophobia or metal objects in body
             (e.g. pacemakers)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Versartis Trial in Pre-pubertal Japanese Children With Growth Hormone Deficiency (GHD) to Assess Long-Acting Growth Hormone (Somavaratan, VRS-317) (NCT02413138)

Eligibility criteria:
Inclusion Criteria:

          -  Chronological Age ≥ 3.0 years and ≤ 9.0 years (girls) or ≤ 10.0 years (boys)

          -  Pre-pubertal status

          -  Diagnosis of GHD as documented by two or more GH stimulation test results

          -  Height SD score ≤ -2.0 at screening

          -  Weight for Stature ≥ 10th percentile

          -  IGF-I SD score ≤ -1.0 at screening

          -  Delayed bone age

        Exclusion Criteria:

          -  Prior treatment with any growth promoting agent

          -  History of, or current, significant disease

          -  Chromosomal aneuploidy, significant gene mutations (other than those that cause GHD)
             or confirmed diagnosis of a named syndrome

          -  Birth weight and/or birth length less than 5th percentile for gestational age

          -  A diagnosis of Attention Deficit Hyperactivity Disorder

          -  Daily use of anti-inflammatory doses of glucocorticoid

          -  Prior history of leukemia, lymphoma, sarcoma or cancer

          -  Ocular findings suggestive of increased intracranial pressure and/or retinopathy at
             screening

          -  Significant spinal abnormalities including scoliosis, kyphosis and spina bifida
             variants

          -  Significant abnormality in screening laboratory studies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 10 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application (NCT03998098)

Eligibility criteria:
Inclusion Criteria:

          1. Subject is informed and has been given ample time and opportunity to think about
             his/her participation and has given his/her written informed consent

          2. Subject is ≥18 years of age

          3. Subject's health status: individual is considered to be healthy (hypertension and
             hypotension is permissible. Other stable diseases at the time of testing are also
             permissible)

          4. Subject is capable of undergoing controlled hypoxaemia to the levels called for the in
             the protocol with minimal medical risk (unless only participating in the blood
             pressure study).

        Exclusion Criteria:

          1. Subject cannot expose their face fully for a reading to be taken

          2. Subject is unable to give informed consent

          3. Subject is outside of the specified age range

          4. Subject has already taken part in the study (all 4 sub studies)

          5. Subject with significant irregular heart rhythm or any disease that might affect the
             results of the study

          6. Subject is not capable of undergoing controlled hypoxia and would be placed at undue
             medical risk if this occurred

          7. Subject has any contraindications identified that would deem them unsuitable to take
             part
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Cough Monitoring Study (NCT01263626)

Eligibility criteria:
Inclusion Criteria:

        Arm 1: healthy volunteers:

          1. Male and female volunteers 18 years of age and older

          2. No history of chronic or acute cough and throat clearing

          3. Ability to read a 5th grade script written in English for approximately 20 minutes

        Arm 2: patients:

          1. Male and female volunteers 18 years of age and older

          2. Cough as chief complaint

          3. Referred to the GI clinic to evaluate if reflux is the cause of their chief complaint

          4. pH testing for standard of care purposes

        Exclusion Criteria:

          -  Subjects who are not able to give informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Prevention of Cystitis. (NCT03744338)

Eligibility criteria:
Inclusion Criteria:

          -  Woman aged 18 to 65, consultant in general medicine. (Any patient meeting the
             inclusion criteria may choose to answer the questionnaire in the waiting room of
             general practitioners selected by lot.)

        Exclusion Criteria:

        -
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? Entailment
Clinical trial: Nociceptors, Neurotrophic Factors and Cytokine Expression in Gastroesophageal Reflux Disease (NCT02114216)

Eligibility criteria:
Inclusion Criteria:

          -  subjects who completed upper GI endoscopy and questionnaires about GERD symptoms

        Exclusion Criteria:

          -  a history of gastrointestinal surgery

          -  Barrett's esophagus

          -  esophageal motility disorder

          -  duodenal ulcer

          -  benign gastric ulcer

          -  gastroduodenal cancer

          -  if he or she had any history of systemic disease requiring chronic medication (except
             for hypertension and diabetes mellitus).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Stem Cell Therapy in Muscular Dystrophy (NCT02241928)

Eligibility criteria:
Inclusion Criteria:

          -  age group of 6 months and above

          -  muscular dystrophy diagnosed on the basis of clinical presentation

        Exclusion Criteria:

          -  presence of respiratory distress

          -  presence of acute infections such as Human Immunodeficient Virus/Hepatitis B
             Virus/Hepatitis C Virus

          -  malignancies

          -  acute medical conditions such as respiratory infection, fever, hemoglobin less than 8,
             bleeding tendency, bone marrow disorder, left ventricular ejection fraction < 30%

          -  pregnancy or breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 60 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Talc Pleurodesis in Patients With Recurrent Malignant Pleural Effusion (NCT00789087)

Eligibility criteria:
Inclusion Criteria:

          -  Malignant pleural effusion confirmed by cytological analysis of pleural fluid and/or
             pleural biopsy;

          -  Recurrent pleural effusion with symptoms;

          -  Chest radiography with lung expansion after thoracocentesis;

          -  Karnofsky Performance Status > 70;

          -  Written informed patient consent were obtained.

        Exclusion Criteria:

          -  Hemorrhagic diathesis;

          -  Active infection;

          -  Cutaneous infiltration;

          -  Patients unable to understand the questionnaires;

          -  Age: > 90 yo or < 18 yo.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Perfusion Imaging With Myocardial Contrast Echocardiography in HCM (NCT02560467)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-80 years

          -  Established diagnosis of HCM

        Exclusion Criteria:

          -  Known history of coronary or peripheral artery disease

          -  History of myocardial infarction

          -  Pregnant or lactating females

          -  Hypersensitivity to any ultrasound contrast agent

          -  Evidence right-to-left or bi-directional intracardiac shunt

          -  Moderate or greater valve disease other than from HCM (systolic anterior motion of the
             mitral valve)

          -  History of septal ablation or myectomy

          -  Hemodynamic instability

          -  Pacemaker dependent heart rhythm
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment