araag2/NLI4PR huggingface dataset:
Clinical trial: Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment (NCT02034487)

Eligibility criteria:
Inclusion Criteria:

          -  All boys identified in the period from January 1990 to February 2013

        Exclusion Criteria:

          -  Misclassified (other diagnoses)

          -  Insufficient data

          -  Lost to follow up
Male
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 20 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effects of Gonadotropin Replacement Therapy in Patients With Hypogonadism (NCT02042638)

Eligibility criteria:
Inclusion Criteria: Serum testosterone concentration < 300ng/dL Absence of a pituitary or
        hypothalamic mass lesions, Presence of gonadotropin response to GnRH, -

        Exclusion Criteria: Previous androgen treatment, diabetes mellitus, arterial hypertension
        other hormone deficiencies

        -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Bone Mineral Density (BMD) in Adolescents With Growth Hormone Deficiency (GHD) (NCT00097526)

Eligibility criteria:
Inclusion Criteria:

          -  Bone age of at least 15 years for girls or at least 16 years for boys within 6 months
             of obtaining the DXA scan

          -  Previous enrollment in the NCGS core study, 85-036

          -  Tanner Stage 4 or greater

          -  Either spontaneous or induced puberty

          -  Subjects who plan on terminating GH treatment for statural purposes for one or more of
             the following reasons: epiphyseal fusion, slowing growth rate indicates that near
             adult height has been reached, or satisfied with current height

        Exclusion Criteria:

          -  Current therapy with a non Genentech GH product

          -  Pregnancy (to avoid exposure to low levels of radiation from DXA scanners)

          -  Bilateral hip replacement

          -  Weight >130 kg (286 lb.)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 17 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparing Pleth Variability Index (PVI) Measurements at Different Sensing Locations (NCT02124551)

Eligibility criteria:
Inclusion Criteria:

          -  18 years of age or older

          -  Undergo any type of surgeries under general anesthesia in UCI Medical Center

          -  Mechanically ventilated during surgery

          -  Arterial line placement is preferred but not required

          -  Agree to sign the consent and HIPAA forms

        Exclusion Criteria:

          -  Less than 18 years of age

          -  Pregnant women

          -  Refused to sign the consent and HIPAA forms

          -  Receive vasoactive medication prior to surgery

          -  Has these conditions: hypotension, hypothyroidism, moderate or poorly controlled
             hypertension, chronic poorly-controlled diabetes, heart failure patients, and patients
             with active airway flow obstruction, left ventricular dysfunction, intra-cardiac
             shunts, right ventricular dysfunction, atrial fibrillation, arrhythmias

          -  patients with surgeries at or around site of sensor placement

          -  Subject has skin abnormalities affecting the digits such as psoriasis, eczema,
             angioma, scar tissue, burn, fungal infection, substantial skin breakdown, nail polish
             or acrylic nails that would prevent monitoring of SpO2 levels during the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Trial of IW-3718 for 8 Weeks in Patients With Symptomatic Gastroesophageal Reflux Disease (GERD) (NCT02637557)

Eligibility criteria:
Inclusion Criteria:

          -  Patient is an ambulatory, community-dwelling male or nonpregnant female and is at
             least 18 years old at the Screening Visit. Lactating females must agree not to
             breastfeed.

          -  Patient has a diagnosis of GERD and reports experiencing GERD symptoms (heartburn or
             regurgitation) on ≥ 4 days per week during the 8 weeks before the Screening Visit
             while taking standard QD PPI therapy.

        Exclusion Criteria:

          -  Patient may not meet any of the excluded conditions specified in the protocol

          -  Patient has any alarm symptoms including but not limited to GI bleeding, anemia,
             vomiting, dysphagia, or unexpected weight loss any time during the Screening or
             Pretreatment Periods

          -  Patient has a history of clinically significant hypersensitivity or allergies to any
             of the excipients contained in the study medication (active or placebo).

        NOTE: Additional inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Tidal Lavage in Knee Osteoarthritis (NCT00000424)

Eligibility criteria:
Inclusion Criteria:

          -  Knee pain attributed to osteoarthritis for at least 1 year.

          -  Meet American College of Rheumatology clinical or clinical plus x-ray criteria for
             knee osteoarthritis

          -  Have at least a moderate pain rating on at least one of the five Western
             Ontario-McMaster University Osteoarthritis Index (WOMAC) scales

        Exclusion Criteria:

          -  Significant conditions of the spine, hips, or feet that affect the ability to walk

          -  Significant medical conditions that affect the ability to walk and function

          -  Inflammatory arthritis, such as rheumatoid arthritis or gout

          -  Degenerative arthritis secondary to other conditions, such as hemochromatosis,
             Wilson's disease, or ochronosis

          -  Current significant soft tissue rheumatism such as fibromyalgia, anserine bursitis, or
             trochanteric bursitis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy and Tolerability of PEG-only Laxative for Fecal Impaction and Chronic Constipation in Children (NCT01592734)

Eligibility criteria:
Inclusion Criteria:

          -  out-patients children with diagnosis of functional constipation or have faecal
             impaction on medical history and physical examination

        Exclusion Criteria:

          -  children with organic causes for defecation disorders, such as Hirschsprung disease,
             spina bifid, hypothyroidism, or other metabolic or renal abnormalities;

          -  Children receiving medication influencing gastrointestinal motility;

          -  Children with suspected gastrointestinal obstruction or stenosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 16 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study Of "Continuous Use" Of Celecoxib Vs. "Usual or Intermittent Use" (NCT00139776)

Eligibility criteria:
Inclusion Criteria:

          -  Subject has been diagnosed, according to American College of Rheumatology guidelines,
             with osteoarthritis of the hip or knee and requires non-steroidal anti-inflammatory
             drugs (NSAIDs) to control their osteoarthritis pain and have access to a touch-tone
             telephone.

        Exclusion Criteria:

          -  Subject has had surgery on index joint.

          -  Subject has history of rheumatoid arthritis or fibromyalgia syndrome.

          -  Subject has active gastrointestinal or cardiovascular disease.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: A Registered Cohort Study on Duchenne Muscular Dystrophy (NCT04012671)

Eligibility criteria:
Inclusion Criteria:

          -  Beyond 2 years old

          -  Diagnosis with Duchenne Muscular Dystrophy, and female carriers, genotypically
             confirmed

          -  Diagnosis should be supported by muscle biopsy, if no genetic confirmation.

        Exclusion Criteria:

          -  Presence of other clinically significant illness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: VERARE_2 Efficacy of the Observation of Virtual Motor Actions for the Improvement of Gait in Patients With ICU-weakness (NCT04713345)

Eligibility criteria:
Inclusion Criteria:

          -  Patient hospitalized in one of the ICU departments or Continuing Medical or Surgical
             Care Units of the Rennes University Hospital for less than 3 months, and presenting
             muscle weakness of the lower limbs with a MRC motor test on the main muscle segments
             giving a score less than or equal to 48/60 (diagnostic criterion of ICU Weakness)

          -  Person of full age;

          -  Affiliation to a social security scheme;

          -  Free, informed and signed written consent.

        Exclusion Criteria:

          -  History of a central neurological event with clinical repercussions

          -  Gait disorders pre-existing to hospitalization in intensive care and limiting the
             walking perimeter (declaration by the patient) or requiring the use of technical
             assistance;

          -  Uncontrolled epilepsy (seizure less than 6 months old);

          -  Adults who are the subject of legal protection (safeguard of justice, curatorship,
             guardianship), persons deprived of their liberty;

          -  Non-French speaking person;

          -  Pregnant or breastfeeding woman.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment