Clinical trial: Comparing Pregnancy Outcomes in Good Prognosis Patients Between Fresh and 'Freeze-All' Single Blastocyst Transfers (NCT02712840)

Eligibility criteria:
Inclusion Criteria:

          -  First IVF cycle

          -  Normal ovarian reserve parameters (antral follicle count > 12, follicle stimulating
             hormone (FSH) < 10 IU/L, AMH (if measured) > 15 pmol/L)

          -  Infertility cause due to tubal factor, male factor with ejaculated sperm or
             unexplained

          -  3 or more fresh transfer or cryopreservation-quality blastocysts on day 5
             post-oocyte-retrieval

          -  GnRH antagonist or long GnRH agonist cycles

        Exclusion Criteria:

          -  Evidence of (or evidence for significant risk of) ovarian hyperstimulation syndrome
             (OHSS) on post-oocyte-retrieval day 5 (in which the standard protocol is not to
             perform a fresh embryo transfer, but rather to freeze all blastocysts for future
             frozen embryo transfers).

          -  Use of a gonadotropin releasing hormone (GnRH) agonist trigger for ovulation and
             resulting intensive luteal phase support protocol.

          -  Women requiring automatic freeze-all approaches (such as for pre-implantation genetic
             testing or cryopreservation for fertility preservation).

          -  Female infertility causes that may adversely affect implantation, such as severe
             endometriosis, fibroids, mullerian abnormalities, or prior uterine procedures
             resulting in a potentially compromised endometrial cavity.

          -  In-vitro maturation of oocytes

          -  Oocyte donation cycles
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction