araag2/NLI4PR huggingface dataset:
Clinical trial: Calibration and Validation of High Quality Low-Cost 3D Printed Pulse Oximeter (NCT02846974)

Eligibility criteria:
Inclusion Criteria:

        - This study has 2 Phases. In Phase 1, healthy, non-smoking adult volunteers greater than
        18 years of age are invited to participate. In Phase 2, all adult (>18) non-critical
        patients and healthy community volunteers visiting the ED at VH and UH are eligible to
        participate.

        Exclusion Criteria:

        Potential participants will be excluded based on the following criteria:

        Phase 1:

          -  greater than 70 years of age,

          -  current smokers,

          -  previous history of cardiac disease (e.g., atrial fibrillation, myocardial infarction,
             congestive heart failure),

          -  history of moderate or severe asthma,

          -  history of seizures,

          -  history of stroke or transient ischemic attack

          -  pregnant women

          -  Patients with any active pulmonary disease such as pneumonia

          -  Individuals who are unwilling to participate or are less than 18 years old

          -  Those who are unable to consent

        Phase 2

          -  Critical patients will be excluded from participating

          -  Individuals who are unwilling to participate or are less than 18 years old will be
             excluded

          -  Those who are unable to consent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Growth Hormone Secretion Following the Anaerobic Exercise (NCT01934270)

Eligibility criteria:
Inclusion Criteria:

          -  Children evaluated for short stature

          -  Normal weight \ overweight \ obesity

        Exclusion Criteria:

          -  Known GH deficiency
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 16 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Vision Response to Dopamine Replacement (NCT01663935)

Eligibility criteria:
Inclusion Criteria:

          -  clinical diagnosis of oculocutaneous albinism

          -  age over 3 and weight over 25 lbs.

        Exclusion Criteria:

          -  ocular only albinism

          -  ocular pathology other than albinism

          -  neurologic disease, history of myocardial infarction, history of clinical depression,
             pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.


Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? Entailment
Clinical trial: To Access the Egyptian COVID-19 Whole Genome by NGS and Compare to the International Worldwide Database (NCT04346043)

Eligibility criteria:
Inclusion Criteria:

        Patients With confirmed COVID-19

        Exclusion Criteria:

        inadequate sample of the patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Hemochromatosis and Iron Overload Screening Study (HEIRS) (NCT00005541)

Eligibility criteria:
No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment
Clinical trial: Long-term Safety and Effectiveness of Growtropin®-II Treatment in Children With Short Stature (NCT04798690)

Eligibility criteria:
Inclusion Criteria:

          -  Children with short stature by growth hormone deficiency(GHD) or idiopathic short
             stature (ISS) or turner's syndrome(TS) or small for gestational age(SGA)

          -  Children who has official height record at least 6 months prior

        Exclusion Criteria:

          -  Children with Epiphyseal closure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Osteoporosis School (NCT00224991)

Eligibility criteria:
Inclusion criteria:

          -  fracture caused by osteoporosis

          -  fifty years or more of age

          -  informed consent

        Exclusion criteria:

        - Physically or mental state that does not participation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Russian Kogenate Pediatric Study (NCT00632814)

Eligibility criteria:
Inclusion Criteria:

          -  Male

          -  Severe hemophilia A or moderate hemophilia A

          -  1-12 years of age

          -  Requiring treatment with FVIII

        Exclusion Criteria:

          -  Current or prior inhibitor or familial antecedents of inhibitor

          -  Surgery required during the study (9 months)

          -  Positive for HIV
Male
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 12 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study Evaluating B-Domain Deleted Recombinant Factor VIII (BDDrFVIII, ReFacto AF) in Patients With Hemophilia A Undergoing Elective Major Surgery (NCT00243659)

Eligibility criteria:
-  Male, at least 12 years old, with severe hemophilia A undergoing major elective major
             surgery requiring FVIII replacement for at least 6 days. Negative FVIII inhibitor test
             at screening and no past history of inhibitor.

          -  Previously treated with at least 150 exposure days to any Factor VIII product

          -  Normal hepatic and renal function tests and no other bleeding disorder
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Glucocorticoid Treatment in Addison's Disease (NCT01063569)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with verified Addison's disease on stable treatment.

        Exclusion Criteria:

          -  Insulin treated Diabetes Mellitus, cardiovascular disease,malignant disease,
             pregnancy.

          -  Treatment with glucocorticoids or drugs that interfere with cortisol metabolism
             (antiepileptics, rifampicin, St. John's wart).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Entailment
Clinical trial: The Efficacy and Safety of Collagen Scaffold Loaded With Umbilical Cord Derived Mesenchymal Stem Cells in Infertile Women With Thin Endometrium or Endometrial Scarring (NCT03592849)

Eligibility criteria:
Inclusion Criteria:

          1. Infertile patients with clear fertility desires

          2. Diagnosed with thin endometrium or endometrial scarring for whom drugs and surgical
             interventions were ineffective

          3. 20-42 years old

          4. Normal ovarian function or with frozen embryos

          5. Willing to actively cooperate with postoperative follow-up

        Exclusion Criteria:

          1. With abnormal chromosome karyotype

          2. With other uterine diseases including large intramural myomas, severe endometriosis,
             severe adenomyosis, severe congenital uterine malformations, endometrial tuberculosis,
             vaginitis and endometritis

          3. Systemic diseases: hypertension, diabetes, and so on

          4. Contraindications to pregnancy

          5. Contraindications to hormone replacement therapy

          6. Medical history of pelvic tumors or receiving pelvic radiotherapy

          7. Involved in other clinical studies

          8. Unable to adhere to the follow-up
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 42 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of Daily Pentoxifylline as a Rescue Treatment in Duchenne Muscular Dystrophy (NCT00243789)

Eligibility criteria:
Inclusion Criteria:

          -  Male

          -  Age 7 years to 100 years

          -  Ability to ambulate for 10 meters. Assistive devices are allowed.

          -  Diagnosis of DMD confirmed by at least one the following:

          -  On stable dose of prednisone, prednisolone or deflazacort for at least 12 months prior
             to screening.

          -  Participants who are on stable dose of any combination of the following compounds
             (creatine, glutamine, coenzyme Q10, vitamin E, C or D, JUVEN, arginine, calcium) must
             have taken these medications for at least 2 months prior to screening. Subjects are
             not required to take these medications to participate in the study.

          -  All other herbs, supplements or green tea (other than those noted above) have been
             discontinued 3 months prior to screening.

          -  Ability to provide reproducible QMT bicep score with no more than 15% variation
             between scores during screening.

          -  Normal blood clotting ability evidenced by a platelet function assessment (PFA).

        Exclusion Criteria:

          -  Currently enrolled in another treatment clinical trial.

          -  History of significant concomitant illness or significant impairment of renal or
             hepatic function.

          -  History of impairment of blood clotting ability (as evidenced by increased PT/PTT or
             PFA over the upper limit of normal (ULN)).

          -  Recent cerebral or retinal hemorrhage.

          -  History of bleeding diathesis or gastric ulcer.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment