araag2/NLI4PR huggingface dataset:
Clinical trial: Association Between the Menstrual Cycle and Weight Loss (NCT01119976)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy females between the ages of 18-40 (inclusive)

          -  BMI between 26.5-35.4 kg/m² (inclusive)

          -  Regular menstrual cycle (28 ± 3 days)

          -  Weight stable (within ± 3-kg) 2 months prior to study inclusion

          -  Must use barrier contraception (e.g. male/female condom) for the study's duration

          -  Must be willing to follow the prescribed diet/exercise plan for the study's duration

        Exclusion Criteria:

          -  On hormonal contraceptives or any other daily use of medications which can make the
             subject unsuitable for inclusion in the study.

          -  Any significant health problem (history of cancer, HIV/AIDS, Diabetes, cardiovascular
             disease, untreated hypothyroidism, etc.)

          -  Restrictions against participating in cardiovascular exercise and strength training

          -  Any condition, which in the opinion of the investigator makes the subject unsuitable
             for inclusion in the study.

          -  Women who are pregnant, lactating, or planning to become pregnant during the study
             period
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Role of Follicular Output Rate in the Prediction of in Vitro Fertilization and Intracytoplasmic Sperm Injection in Women With Unexplained Infertility (NCT02154958)

Eligibility criteria:
Inclusion Criteria:

          -  Unexplained infertility

          -  Both ovaries are present

          -  Day 2 FSH <10 mIU/L

          -  Day 2 Estradiol <80 pg/L

        Exclusion Criteria:

          -  Known other cause of subfertility

          -  Expected poor responders according to Bologna criteria (9)

          -  Abnormalities affecting the uterine cavity

          -  Uncontrolled diabetes

          -  Allergy to gonadotrophins

          -  Cancelled cycles during the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effects of Aerobic Exercise for Treating Alzheimer's Disease (NCT01954550)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of probable or possible Alzheimer's disease (AD);

          -  15≤ Mini-Mental State Examination (MMSE) score ≤26;

          -  Clinical Dementia Rating score 0.5-2;

          -  Community-dwelling, e.g., homes and assisted living;

          -  Age 66 years and older;

          -  English-speaking;

          -  Verified exercise safety by the primary care providers and the cardiologists if
             subjects have significant cardiac history;

          -  Stable on AD drugs >1 month if AD drugs are prescribed.

        Exclusion Criteria:

          -  Resting heart rate (HR) ≤50 or ≥100 beats/min;

          -  Neurological disorders in the past 5 years;

          -  Psychiatric disorders in the past 5 years;

          -  Alcohol or chemical dependency in the past 5 years;

          -  Contraindications to exercise;

          -  New symptoms or diseases that have not been evaluated by a health care provider, e.g.,
             hip fracture, ongoing and unplanned weight loss, severe shortness of breath, deep vein
             thrombosis, hernia, unhealed sores, joint swelling, pain or trouble walking;

          -  Cardiac ischemia or serious arrhythmia on the electrocardiograph during the screening
             exercise test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 66 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Steroids Pharmacokinetics and the Response to Prednisone Therapy in Giant Cell Arteritis (NCT01400464)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of GCA, meeting at least 3 of the following 5 American College of
             Rheumatology (ACR) criteria for the diagnosis of GCA:

               1. At least 50 years of age at disease onset

               2. New onset or new type of localized pain in the head

               3. Temporal artery abnormality (i.e., temporal artery tenderness to palpation or
                  decreased pulsation unrelated to arteriosclerosis of cervical arteries)

               4. ESR of greater than 40 mm in the first hour by the Westergren method

               5. Temporal artery biopsy showing vasculitis characterized by a predominance of
                  mononuclear cell infiltration or granulomatous inflammation, usually with
                  multinucleated giant cells

          -  Corticoid treatment since less than 14 days

          -  Signed informed consent

          -  Affiliation to the social security system

        Exclusion Criteria:

          -  Dementia

          -  Predictable non observance

          -  Neoplasia since less than 5 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: Preoperative Etanercept Before Inguinal Hernia Surgery (NCT00825344)

Eligibility criteria:
Inclusion Criteria:

          1. Demonstrable hernia evident using ultrasound, computed tomography, or on physical
             exam.

          2. Pt scheduled for unilateral inguinal hernia repair.

          3. Symptoms present for < 6 months.

        Exclusion Criteria:

          1. Non-elective surgery.

          2. Previous hernia repair at the same site, or surgery near the site of the hernia.

          3. Demyelinating neurological disease.

          4. Current or recent (< 6 years) history of substance abuse.

          5. Pregnancy, which will be ruled out by a urine pregnancy test in women of childbearing
             age.

          6. Pre-existing untreated psychiatric condition that could preclude an optimal treatment
             response (e.g. untreated posttraumatic stress disorder).

          7. Unstable medical condition (e.g. unstable angina or congestive heart failure or
             severe).

          8. Rheumatoid arthritis, or other systemic conditions that might respond to TNF
             inhibitors.

          9. Pt is immunosuppressed or is taking other drugs (e.g. corticosteroids) that might
             suppress the immune system.

         10. Systemic infection.

         11. Any opioid analgesics within 48 hours of skin incision.

         12. Any use of tricyclic antidepressants, serotoninin-norepinephrine reuptake inhibitors,
             or anticonvulsants within 72 hours of skin incision.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Wedged Orthoses and Knee Osteoarthritis (NCT00420147)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed unilateral knee osteoarthritis by a qualified physician

          -  Recent (within 3 months of entrance into the study) radiographic confirmation of OA
             grade (I-IV) as evidenced by joint space narrowing and the presence of osteophytes

          -  A score of 50-90 mm on a 100 mm visual analogue pain scale for walking

          -  Ability to walk independently without the use of assistive devices

        Exclusion Criteria:

          -  History of lower extremity joint surgery or other lower extremity injury that would
             hinder ambulation

          -  Severe foot deformity that would prevent the accommodation of the wedged orthotic
             device

          -  Other disease process such as neurologic, cardiac, or oncologic, that would hinder
             one's ability to ambulate

          -  Any condition, such as diabetes, that results in loss of sensation in the lower
             extremities
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy (NCT03657745)

Eligibility criteria:
Inclusion Criteria:

          -  Alzheimer's disease

          -  Cognitive Impairment

        Exclusion Criteria:

          -  any previously noted epileptic seizures, including febrile seizures.

          -  any significant disease of the eye, such as macular degeneration. Since the 40Hz light
             therapy is delivered via eye stimulation, healthy eyes are required.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Brain Network Activation and Gait and Posture in FXTAS (NCT02936531)

Eligibility criteria:
Inclusion Criteria:

          -  FMR1 premutation carriers (55-200 CGG repeats)

          -  symptomatic (with possible or probable FXTAS) or neurologically asymptomatic.

        Exclusion Criteria:

          -  Severe disability unable to perform tests

          -  treatment with neuroleptics

          -  other brain disease or pathology

          -  deafness or blindness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Contradiction
Clinical trial: Adductor Canal Block Versus Intra-articular Steroid and Lignocaine in Knee Osteoarthritis Pain Management (NCT04264481)

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic Knee Osteoarthritis according to criteria of American College of
             Rheumatology

               -  Antero-medial knee pain of at least 6 months duration

               -  Matching symptoms with Knee X-ray findings of KOA

               -  Kellgran-Lawrence staging of 2-4

               -  Pain score of at least NRS(Numerical Rating Scale) 4/10 during weight bearing

        Exclusion Criteria:

          -  Presence of other knee diseases such as fracture or rheumatic diseases

          -  Referred pain from the back suggestive of lumbar radiculopathy

          -  Previous knee surgery

          -  Lateral knee pain

          -  History of knee joint injections (Intra-articular injections or ACB) within 3 months
             of study

          -  Neuropathic knee pain

          -  Unable to give consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment