araag2/NLI4PR huggingface dataset:
Clinical trial: Double-blind Placebo Controlled Study of Oxytocin in Fragile X Syndrome (NCT01254045)

Eligibility criteria:
Inclusion Criteria:

          1. Confirmed genetic diagnosis of Fragile X (FraX) (full mutation).

          2. Male (who have more serious effects due to the X chromosome nature of the disorder)

          3. Age 13-29 years.

          4. Parent of adolescent must be willing to sign informed consent.

          5. Intelligence Quotient (IQ) > 42.

        Exclusion Criteria:

          1. Cardiac risk factors.

          2. Medication exclusions: opiates or opiate antagonists, corticosteroids, typical or
             atypical antipsychotics.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 29 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Phase 3 Papulopustular Rosacea Study (NCT01494467)

Eligibility criteria:
Inclusion Criteria:

          1. The subject has papulopustular rosacea with an Investigator Global Assessment (IGA)
             score rated 3 (moderate) or 4 (severe),

          2. The subject has at least 15 but not more than 70 inflammatory lesions (papules and
             pustules) on the face.

        Exclusion Criteria:

          1. The subject has particular forms of rosacea (rosacea conglobata, rosacea fulminans,
             isolated rhinophyma, isolated pustulosis of the chin) or other facial dermatoses that
             may be confounded with papulopustular rosacea, such as peri oral dermatitis, facial
             keratosis pilaris, seborrheic dermatitis, and acne,

          2. The subject has rosacea with more than two nodules on the face.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Biomechanical and Morphological Changes in Dystrophic Muscle (NCT02472990)

Eligibility criteria:
Inclusion Criteria:

          -  Young man ou woman (5 to 17 years old) with Duchenne Muscular Dystrophy (confirmed by
             immunohistochimy on the muscular biopsy and/or mutation in the dystrophin confirmed by
             molecular biology)

          -  Time more than 7 secondes to test of 10 m and/or distance less than 330 m to walk test
             of 6 minutes. These values are recent markers to include children with a strong risk
             of loss of walking ability in 2 years.

          -  Parental inform sign consent and / or child inform consent

        Exclusion Criteria:

          -  Recent orthopaedic surgery of lower limbs (6 months)

          -  Other chronic disease associated, which have an impact on the walking

          -  Cognitive Deficiency or behavior disorders limiting the understanding of the study

          -  Children who can benefit ATU (translarna ® or other) during the study

          -  All MRI contradications : pacemaker or neurosensory stimulator or implantable
             defibrillator, neurosurgical valves, cochlear implant or ferromagnetic implants near
             nervous structures, brace, metallic prostheses, not cooperative or agitated patients,
             patient claustrophobic, pregnant woman.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 17 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Physiotherapeutic Intervention in Children With Chronic Functional Constipation (NCT00906971)

Eligibility criteria:
Inclusion Criteria:

          -  Less than 2 per week defecation

          -  Fecal incontinence

          -  Retentive behavior

          -  Pain at defecation and

          -  Hard stools

        Exclusion Criteria:

          -  Medication use (calcium, antacid, diuretic and hematinic)

          -  Organic causes (spina bifid, hypothyroidism, hirschusprung disease, developmental
             delay neuropsychomotor, kidney disease and metabolic diseases)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparison of Circular(Soave) and Heart-shaped Anastomosis in Hirschsprung's Disease: A Prospective Multicenter Randomized Controlled Trial (NCT02234219)

Eligibility criteria:
Inclusion Criteria:

          1. Age<14 years

          2. Hirschsprung's disease diagnosed by biopsy

          3. Surgical indication

        Exclusion Criteria:

          1. Age>14 years

          2. Not Hirschsprung's disease

          3. Surgical contraindication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 14 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Entailment
Clinical trial: A Pilot Study to Assess the Accuracy of Blood Pressure Assessment by the Omron HeartGuide Smartwatch (NCT03986281)

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  Post-operative cardiac surgery patients on the ICU floors at the Cleveland Clinic Main
             Campus

          -  Wrist size range ranging from 16 cm to 19 cm

        Exclusion Criteria:

          -  Wrist size range smaller than 16 cm or larger than 19 cm

          -  Use of a radial artery graft for coronary artery bypass grafting
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study to Evaluate CORT125134 in Participants With Cushing's Syndrome (NCT02804750)

Eligibility criteria:
Inclusion Criteria:

          1. Has a confirmed diagnosis of endogenous Cushing's syndrome.

          2. Requires medical treatment of hypercortisolemia.

          3. Meets at least one of the following criteria:

               1. Has type 2 diabetes mellitus.

               2. Has impaired glucose tolerance.

               3. Has hypertension.

        Exclusion Criteria:

          1. Has non-endogenous source of hypercortisolemia

          2. Has uncontrolled, clinically significant hypothyroidism or hyperthyroidism

          3. Has poorly controlled hypertension

          4. Has Stage ≥ 4 renal failure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Entailment
Clinical trial: Trial of L-DOPA as a Treatment to Improve Vision in Albinism (NCT01176435)

Eligibility criteria:
Inclusion Criteria:

          -  Age 3 to 60 years with albinism

        Exclusion Criteria:

          -  Glaucoma or at increased risk of glaucoma

          -  History of dystonia

          -  History of melanoma

          -  Planning to undergo eye muscle surgery during study time frame

          -  Undergoing vision therapy

          -  Taking iron supplements or vitamins with iron

          -  Taking medication for ADHD

          -  Known liver or gastrointestinal disease

          -  Previous treatment with levodopa

          -  Psychological problems

          -  Ocular abnormalities other than those associated with albinism

          -  Pregnant, nursing or planning to become pregnant during study

          -  Known allergy to levodopa/carbidopa
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? Entailment
Clinical trial: A 12-week Human Trial to Compare the Efficacy and Safety of Polycan on Bone Metabolism (NCT01402115)

Eligibility criteria:
Inclusion Criteria:

          -  They were required to have reduced bone density but no evidence of osteoporosis or
             osteopenia by Dual-emission X-ray absorptiometry (DEXA) scan (T ≥ -1.0 in the lumbar
             spine).

          -  Perimenopausal women : aged 40-70

        Exclusion Criteria:

          -  Women with a body mass index (BMI) >30 kg/m2 or who were being treated with estrogens,
             corticosteroids, or bisphosphonates, or who had significant illness affecting bone
             metabolism were excluded
Female
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy and Safety Study for the Treatment of Dysfunctional Uterine Bleeding (NCT00307801)

Eligibility criteria:
Inclusion Criteria:

          -  Women 18 years or older

          -  And with a diagnosis of dysfunctional uterine bleeding without organic pathology

          -  And with at least one of the following symptoms: prolonged, frequent or excessive
             bleeding.

        Exclusion Criteria:

          -  The use of steroidal oral contraceptives, or any drug that could alter oral
             contraception metabolism will be prohibited during the study.

          -  Women with a history of endometrial ablation or dilatation and curettage within 2
             months prior to study start will be excluded.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment