araag2/NLI4PR huggingface dataset:
Clinical trial: Involvement of Immune Cells Derived From the Intestine in Sjogren's Syndrome (NCT03841318)

Eligibility criteria:
Inclusion Criteria:

          -  Suspicion of Sjogren's syndrome based on 2016 American College of Rheumatology (ACR)
             criteria;

          -  Age ≥ 18 years

          -  Being affiliated to health insurance

          -  Willing to participate

        Exclusion Criteria:

          -  Pregnant or breastfeeding women,

          -  Patient concerned by articles L 1121-5 to L 1121-8 (persons deprived of their liberty
             by a judicial or administrative decision, minors, persons of legal age who are the
             object of a legal protection measure or unable to express their consent)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Improve Osteoarthritis Care (NCT04670549)

Eligibility criteria:
Inclusion Criteria:

          -  Self-reported hip or knee osteoarthritis

        Exclusion Criteria:

          -  Persons who do not understand the Norwegian language
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Transcriptomic Profile of Endometrium in Different Histological Dating of Natural Cycle (NCT03222830)

Eligibility criteria:
Inclusion Criteria:

          -  The inclusion criteria for RIF group were: unexplained repeated implantation failure
             (RIF) is defined as the absence of a gestational sac on ultrasound at 5 or more weeks
             after embryo transfer (ET) after 3 embryo transfers with high quality embryos or after
             the transfer of ≥10 embryos in multiple transfers.

        The inclusion criteria for control group were: (1) age <35 years; (2) regular menstrual
        cycles of 24-35 days; (3) baseline follicle- stimulating hormone (FSH) < 9.0 IU/L; (4)
        endometrial thickness ≥8.0 mm on the day of hCG administration.

        Exclusion Criteria:

          -  (1) uterine abnormalities (double uterus, bicornuate uterus, unicornuate uterus); (2)
             intrauterine adhesions（moderate - severe）, endometriosis, adenomyosis, untreated
             hydrosalpinx, uterine fibroids (submucosal fibroids, nonmucosal fibroids >4.0 cm
             and/or endometrial pressure) (3) history of adverse pregnancy (including spontaneous
             abortion, stillbirth, and fetal malformation).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Safety Study of Mini-dystrophin Gene to Treat Duchenne Muscular Dystrophy (NCT00428935)

Eligibility criteria:
Inclusion Criteria:

          -  Known null mutation of the Dystrophin gene

          -  Male age of 5 years or older

          -  If taking corticosteroids, must have dose unchanged for the past 3 months

          -  Serum creatine kinase elevation greater than 10x normal value (established by
             Children's Hospital)

          -  Progressive, symmetrical proximal muscle weakness of arms and legs

        Exclusion Criteria:

          -  Unable to cooperate for muscle strength testing

          -  Joint contractures that prohibit muscle strength testing

          -  Concomitant illness

          -  Individuals predisposed to excessive vagal responses (bradyarrhythmia or hypotension)

          -  Controlled substance abuse
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 15 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Pharmacokinetics, Metabolism, Efficacy, and Safety Study of Two Testosterone Matrix Transdermal Systems (NCT01323140)

Eligibility criteria:
Inclusion Criteria:

          -  Male, 18 - 65 years of age;

          -  Documented testosterone deficiency;

          -  BMI 18 to 33.

        Exclusion Criteria:

          -  Evidence of prostate cancer and benign prostate hyperplasia;

          -  Taking medications that interfere testosterone metabolism;

          -  History of alcohol or drug substance abuse;

          -  Abnormal ECG;

          -  Allergic to transdermal products;

          -  Skin condition that interfere transdermal system application and assessment
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluating the Immune Response for COVID-19 (NCT04348422)

Eligibility criteria:
Inclusion Criteria:

          -  Positive COVID-19 RT-PCR to the subject or his/her household.

          -  Over 18 years old

          -  Ability to sign an informed consent

        Exclusion Criteria:

          -  Inability to sign an informed consent

          -  Pregnancy
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Recurrent Inguinal Hernia Treatment - Lichtenstein Versus Laparoscopic Totally Extraperitoneal Preperitoneal Hernioplasty (NCT00642200)

Eligibility criteria:
Inclusion Criteria:

          -  recurrent inguinal hernia

          -  willing to participate

        Exclusion Criteria:

          -  unwilling to participate

          -  bilateral hernia

          -  preference towards either treatment arm
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of the Goldstein SonoBiopsy™ Catheter for Diagnosing Endometrial Pathology (NCT01969396)

Eligibility criteria:
Inclusion Criteria:

          -  Patient with thickened endometrium

          -  Abnormal uterine bleeding

        Exclusion Criteria:

          -  Pregnant

          -  Active pelvic infection

          -  Pelvic inflammatory disease

          -  Blood clotting disorders

          -  Sexually transmitted disease

          -  Uterine perforation

          -  Recent cesarean section
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: HECTHOR: Humira to Spare Steroids in Giant Cell Arteritis (NCT00305539)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 50 years

          -  ACR criteria for Giant cell arteritis (HUNDER 1990)

          -  Positive Temporal artery biopsy

          -  Plus standard inclusion criteria for Humira protocols

        Exclusion Criteria:

          -  Prednisone treatment for a different disease at a dose >15 mg/day

          -  Corticoid treatment for GCA more than 10 days

          -  GCA treatment with prednisone > 1 mg/kg whatever period of time

          -  GCA treatment with an anti-TNF, MTX, cyclosporine, cyclophosphamide, dapsone or
             steroid bolus

          -  Recent, permanent or transient visual loss due to GCA and the presence of any specific
             visual abnormality (diplopia, hallucination)

          -  Plus standard exclusion criteria for Humira protocols
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluation of Medicines Use Review in Slovenia (NCT04417400)

Eligibility criteria:
Inclusion Criteria:

          -  at least one prescription medicine for a chronic condition for at least six months

          -  deemed to be suitable for MUR by a pharmacist, certified to provide the MUR service;

          -  ability to communicate in Slovenian; The inclusion of patients was performed in
             accordance with the SOP MUR, to reflect how patients are generally offered MUR service
             in Slovenia.

        Exclusion Criteria:

          -  urgent need of MUR (the service delay due to randomization would risk their health);

          -  referred for MUR by a healthcare professional (general practitioner, nurse, etc.);

          -  the patient's carer, rather than the patient themselves, was able to attend the
             interviews and receive MUR;

          -  previously received MUR or an advanced medication review;

          -  difficulties understanding, communicating or other issues (vision, hearing) that might
             affect study outcomes.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: The Factors Associated With the Recurrence in Patients With Cushing Disease (NCT02233335)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosed Cushing's disease

        Exclusion Criteria:

          -  Already received treatment in other hospital

          -  Ectopic Cushing's syndrome
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Entailment