araag2/NLI4PR huggingface dataset:
Clinical trial: ATHN 8: PUPs Matter Study (NCT03818529)

Eligibility criteria:
Inclusion Criteria:

          -  Congenital hemophilia A; FVIII </=5% or congenital hemophilia B; FIX </=5%;

          -  Birth date on or after January 1, 2010;

          -  Care established at one of the participating HTCs;

          -  Co-enrollment in the ATHNdataset; and

          -  Parent or authorized guardian can provide informed consent

        Exclusion Criteria:

          -  Patients who are referred to the HTC with no record of bleed and factor utilization
             data
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 13 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Neuromuscular Ultrasound in ALS (NCT01785550)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects referred to the electromyography laboratory for ALS.

        Exclusion Criteria:

          -  Patients with known comorbid myopathy or neuropathy will be excluded from the study.

          -  Patients unable to provide their own consent will be excluded.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Robotic Assisted Surgery for Treatment of Gynecological Diseases: Pilot Study (NCT03093675)

Eligibility criteria:
Patient Inclusion Criteria:

          -  Age ≥ 18 years old

          -  Sign the informed consent form

          -  BMI ≤ 40

          -  A.S.A. Class < III or IV

        Disease Inclusion Criteria:

          -  Ovarian cyst (enucleation/oophorectomy)

          -  Prophylactic bilateral oophorectomy

          -  Ectopic pregnancy (salpingotomy/salpingectomy)

          -  Tubal inflammatory disease (salpingotomy/salpingectomy)

          -  Infertility and sterility (treatment of endometriosis, chromo-salpingography, etc.)

          -  Benign uterine disease (Fibromatosis, Adenomyosis)

          -  Endometrial hyperplasia

          -  Stage Ia G1-2 Endometrial tumors

          -  Precancerous lesions of the uterine cervix

          -  Stage Ia uterine cervical tumors

          -  Pelvic endometriosis

        Patient Exclusion Criteria:

          -  Pregnancy

          -  Liver disease

          -  Coagulation disorders

          -  Patient internal or anatomical criteria that preclude a laparoscopic approach
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Assessment of Endometrial and Sub-endometrial Vascularity Before and After PRP Infusion in Frozen Embryo Transfer Cycles (NCT04247204)

Eligibility criteria:
Inclusion Criteria:

          -  Subfertile women undergoing frozen-thawed embryo transfer with at least previously
             failed one ICSI cycle.

          -  Age between 20-35 years.

          -  Women with endometrium thickness between 8-14 mm on D15 of the frozen embryo transfer
             cycle

        Exclusion Criteria:

          -  Women with a thin endometrium (≤ 7 mm) on day 15 of the cycle.

          -  Women with known hematological or immunological disorders

          -  Women with uncontrolled endocrine or other medical conditions, such as
             hyperprolactinemia or thyroid diseases.

          -  Women with uterine abnormalities e.g. Asherman syndrome, myomas, uterine septum,
             bicornuate uterus.

          -  Women who refuse to participate in the study.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Spine Kinematics and Center of Pressure Excursion During Functional Task Vertebral Compression Fractures Subjects (NCT04135755)

Eligibility criteria:
Vertebral compression fracture Inclusion Criteria:

        older than 65 years osteoporosis diagnosed by a bone mineral density test of the lumbar
        spine (T-score < -2.5; T: peak bone mass) thoracic-lumbar VCF on radiography without
        displacement

        Vertebral compression fracture Exclusion Criteria:

        other spinal diseases that might also cause back pain (such as scoliosis, lumbar
        spondylolisthesis, lumbar disk disease, and spinal stenosis) a history of diabetes a
        history of neurological disease (such as cerebral vascular disease, peripheral neuropathy
        and vestibular disease).

        Control Inclusion Criteria:

        None the control participants had evidence of gait, postural, or spine disorders.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation, Treatment, and Follow-up of Patients With Lyme Disease (NCT00028080)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Clinical diagnosis of active Lyme disease at the time of the initial NIH evaluation
             based on the CDC case definition. Study physician will review history to confirm
             probable cases.

          -  Subjects must maintain a private physician for non-protocol related medical complaints
             and for emergency medical treatment required for these or other of their disorders.

        EXCLUSION CRITERIA:

          -  Post treatment Lyme disease syndrome.

          -  Unacceptably poor compliance, which, in the opinion of the investigator, would
             interfere with one's ability to study or provide quality medical care for the patient.

        ELIGIBILITY CRITERIA TO UNDERGO APHERESIS:

          -  Age 18 years or above.

          -  Weight greater than 110 pounds.

          -  No known heart, lung, kidney disease, or bleeding disorders.

          -  Negative HIV, HCV and HBsAg serologies.

          -  Female subjects should not be pregnant or nursing.

          -  Patients will have a CBC performed up to 2 weeks before the procedure. In order to be
             able to undergo the procedure, patient must fulfill all of the below:

               -  Hemoglobin greater than 11 g/dL for males and greater than 10 g/dL for females.

               -  Platelets greater than 150 k/mm(3).

               -  WBC greater than 3.5 x 10(3) uL.

               -  MCV above 80.

        Women who are able to conceive children must have a negative pregnancy test within 2 weeks
        before the procedure.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of Hand Functions and Wrist Proprioception in Patients With and Without Psoriatic Arthritis (NCT04553302)

Eligibility criteria:
Inclusion Criteria:

          -  to be diagnosed according to CASPAR or ACR/ EULAR 2010 criteria for patient groups

          -  taking regular medication for patient groups,

          -  have complaints related to hand / wrist joints for patients groups,

          -  have no complaints related to upper extremity for asymptomatic healthy group.

          -  have any rheumatologic disease and OA diagnosed according to traditional criteria

        Exclusion Criteria:

          -  finger infection and / or finger amputation,

          -  using orthoses,

          -  to report a diagnosis of neurological disease,

          -  to report a history of trauma or surgery involving the upper extremity,

          -  to report a psychiatric and / or cognitive problem
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Biomechanical Analysis of Gait in Individuals With Duchenne Muscular Dystrophy (NCT00312247)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of DMD

          -  Male.

          -  Four years of age or older.

          -  Ability to walk independently for five minutes to 10 minutes at self-selected speed.

          -  Ability to cognitively understand directions for testing procedures.

        Exclusion Criteria:

          -  Female

          -  Nonambulatory
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 21 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis (NCT01557868)

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic knee osteoarthritis presenting to physician's office

          -  Radiographic evidence of knee osteoarthritis

          -  Age 18 years or older

          -  Failed minimum of 3 months of non-operative treatment, including, but not limited to,
             Tylenol, anti-inflammatory medication, cortisone injection, physical therapy, bracing,
             and/or heel wedge

          -  Symptoms for at least 3 months

        Exclusion Criteria:

          -  Associated ligamentous instability

          -  History of deep knee infection

          -  Candidate for total knee arthroplasty or arthroscopy

          -  Peripheral neuropathy.

          -  X-rays that are completely negative and only MRI evidence or arthroscopic evidence
             (from previous arthroscopy) of OA.

          -  Prior HA injections at any point in the past

          -  Chondrocalcinosis

          -  Patients with precautions or contraindications for viscosupplementation use

          -  Cortisone injection within past 3 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: The Efficacy of Transversus Abdominis Plane Block After Groin Hernia Repair (NCT01052285)

Eligibility criteria:
Inclusion Criteria:

          -  18-75 years old

          -  groin hernia repair

          -  written consent

          -  ASA 1-3

          -  BMI 18-35

        Exclusion Criteria:

          -  unable to communicate in Danish

          -  relevant drug allergy

          -  pain medication in the last 24 hours

          -  pregnancy

          -  alcohol or/and drug abuse

          -  daily opioid intake

          -  infection at injection site
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment