araag2/NLI4PR huggingface dataset:
Clinical trial: A Study of the Efficacy and Safety of Ulipristal Acetate Intermittent Treatment for Abnormal Uterine Bleeding Associated With Leiomyomas (NCT02147158)

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal women, 18-50 years, inclusive.

          -  Cyclic abnormal uterine bleeding (heavy or prolonged).

          -  Menstrual blood loss (MBL) of ≥ 80 mL as measured by the alkaline hematin method in
             the first 8 days of menses.

          -  Minimum of one discrete leiomyoma observable by transvaginal ultrasound.

          -  Endometrial biopsy without evidence of malignancy or atypical or non-atypical
             hyperplasia.

        Exclusion Criteria:

          -  History of uterine surgery that would interfere with the study endpoints.

          -  Known coagulation disorder including bleeding disorder or clotting disorder.

          -  History of, or current uterine, cervix, ovarian, or breast cancer.

          -  Alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP),
             or total bilirubin two times or greater than the upper limit of normal range.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Clomiphene Citrate in Combination With Gonadotropins for Ovarian Stimulation in Women With Poor Ovarian Response. (NCT02237755)

Eligibility criteria:
Inclusion Criteria:

          -  Women with poor response to ovarian stimulation. The definition of poor response was
             based on the presence of at least one of the following criteria: Age > 40 years old,
             day 2 FSH >9.5 mIU/ml, AMH < 2ng/ml ,at least one previous COH with less than 3
             oocytes retrieved, at least one cancelled attempt due to poor response, estradiol less
             than 500 pg/ml on the day of HCG.

        Exclusion Criteria:

          -  All other women that do not fulfill the above mentioned criteria
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Electrocoagulation Employment During TAPP Inguinal Hernia Repair (NCT03566784)

Eligibility criteria:
Inclusion Criteria:

          -  age ≥18 years

          -  unilateral inguinal hernia

          -  no previous intraabdominal operations

          -  no history of neurological diseases

        Exclusion Criteria:

          -  recurrent inguinal hernia

          -  bilateral inguinal hernia

          -  history of chronic pain syndrome

          -  preoperative ASA classification IV-V
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of Cuff-Less Wrist Wearable Blood Pressure Device to Cuff Based Blood Pressure Measuring Devices (NCT04835857)

Eligibility criteria:
Inclusion Criteria:

          -  Health volunteers 18 years and above; equal numbers of males and females to address
             Sex As a Biological Variable (SABV); and in sinus rhythm.

          -  Agree to commit to participate in the current protocol.

          -  Provide written informed consent prior to any study procedures being performed (all
             subjects should be able to understand the informed consent form and any other
             documents that subjects are required to read).

        Exclusion Criteria:

          -  Unable or unwilling to provide informed consent

          -  Any other condition that would increase the risk of participation in the study in the
             opinion of the site Investigator.

          -  A difference of >10 mm Hg in left versus right arm oscillometric systolic BP.

          -  Upper extremity arteriovenous hemodialysis shunt.

          -  Wrist distortion or pain from arthritis.

          -  Prior trauma or surgery at the radial artery monitoring site.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Historically Controlled Trial of Corticosteroids in Young Boys With Duchenne Muscular Dystrophy (NCT02167217)

Eligibility criteria:
Inclusion Criteria:

          1. Appropriate degree of weakness for age, creatine kinase greater than 20 times the
             upper limit of normal, and genetic mutation known to be causative for Duchenne
             muscular dystrophy .

          2. Appropriate degree of weakness for age, creatine kinase greater than 20 times the
             upper limit of normal and genetic or biopsy confirmation of Duchenne muscular
             dystrophy in a primary relative (e.g. brother or maternal uncle).

          3. De-identified, genetic studies will be reviewed by collaborator Kevin Flanigan, MD
             prior to enrollment of subjects.

          4. Age at entry: one month through 30 months.

        Exclusion Criteria:

          -  Prior treatment with corticosteroids
Male
No healthy subjects accepted to join the trial.
Subject must be at least 1 Month old.
Subject must be at most 30 Months

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Characteristics and Health Related Quality of Life in Idiopathic Pulmonary Fibrosis (NCT03171870)

Eligibility criteria:
Inclusion Criteria:

          -  Idiopathic Pulmonary fibrosis will be diagnosed by presence of UIP pattern. Other
             forms of ILD will be diagnosed using HRCT by presence of Reticular abnormality
             Honeycombing with or without traction Extensive ground glass abnormality.

          -  Profuse micronodules.

        Exclusion Criteria:

          -  Patients who refused to participate in the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Entailment
Clinical trial: Pulmozyme for Sjogren's Associated Cough (NCT01357447)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years or above with primary Sjogren's disease (as defined by the American
             European Consensus Group Criteria), and complaint of chronic cough.

          -  Able to give consent and anticipated ability to adhere to the study procedures.

        Exclusion Criteria:

          -  Diagnosis of COPD, emphysema, asthma, chronic bronchitis, other clinically significant
             lung disease that is likely to cause cough. Interstitial lung disease associated with
             Sjogren's is not excluded.

          -  Cigarette use of greater than 20 pack years or regular use within 6 months

          -  Allergy or intolerance to Pulmozyme.

          -  Acute respiratory infection or other acute respiratory illness during the prior month.

          -  LCQ greater than 17 and VAS less than 3 cm at baseline (Visit 1).

          -  Pregnancy or breast feeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Contradiction
Clinical trial: Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis (NCT03344913)

Eligibility criteria:
Inclusion Criteria:

        Adults with Osteoarthritis:

          -  Age 50-80

          -  radiographic evidence of knee osteoarthritis (OA participants)

          -  self-report current non-smoker

          -  willing and able to walk for 30 minutes a day three days a week for six weeks at a
             location that is within 30 minutes from University of Maryland Baltimore

          -  speaks English

        Healthy Controls:

          -  Age 50-80

          -  self-reports no osteoarthritis

          -  self-report current non-smoker

          -  willing and able to walk for 30 minutes a day three days a week for six weeks at a
             location that is within 30 minutes from University of Maryland Baltimore

          -  speaks English

        Exclusion Criteria:

          -  unable to pass the evaluation to sign consent

          -  diagnosis of rheumatoid arthritis

          -  diagnosis of gout

          -  diagnosis of heart failure

          -  diagnosis of chronic obstructive pulmonary disease

          -  diagnosis of diabetes

          -  diagnosis of Parkinson's disease

          -  diagnosis of Alzheimer's disease

          -  diagnosis of autoimmune disease

          -  currently taking long-term steroid medications such as methotrexate

          -  weight less than 110 lbs.

          -  direct employee of the PI
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Alzheimer's Disease Reminiscence Quality of Life (NCT01295957)

Eligibility criteria:
Inclusion Criteria:

          -  Alzheimer's disease

          -  Able to communicate

        Exclusion Criteria:

          -  Active major psychiatric disorders

          -  Acute or unstable chronic medical conditions

          -  Blindness

          -  Deafness
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 87 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: A Pilot Study to Assess the Effects of Pre-SMA LF-rTMS for the Treatment of Essential Tremor (NCT02763865)

Eligibility criteria:
Inclusion Criteria:

          -  Greater than 18 of age

          -  Meet the diagnostic criteria for essential tremor with visible upper limb tremor

          -  Must be either on stable medications to treat tremor for 30 days, or no medications to
             treat tremor

        Exclusion Criteria:

          -  History of seizures

          -  History of chronic pain conditions

          -  Any metal in their body above their shoulders

          -  Use of medications that lower seizure threshold including:

               -  broad classes of drugs such as tricyclic antidepressants

               -  anti-psychotics

               -  neuroeptics

               -  thyroid medications and stimulants

          -  Use of any medications that cause tremor, Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment