araag2/NLI4PR huggingface dataset:
Clinical trial: Evaluation of Women's Experience With EVRA (Norelgestromin + Ethinyl Estradiol) Transdermal Contraceptive Patch Compared With Previous Methods of Contraception. (NCT00261482)

Eligibility criteria:
Inclusion Criteria:

          -  Regular menstrual cycles

          -  sexually active and at risk of pregnancy

          -  nonpregnant

          -  normal Pap smear

        Exclusion Criteria:

          -  Presently have or at risk of venous thrombosis or arterial thrombosis

          -  migraines with focal aura

          -  severe hypertension

          -  diabetes mellitus

          -  hereditary dyslipoproteinemia

          -  carcinoma of breast, endometrium or other estrogen-dependent neoplasia

          -  substance abuse

          -  skin conditions

          -  concurrent use of hormone-containing medication

          -  smoking women over 35 years of age.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Idiopathic Pulmonary Fibrosis Job Exposures Study (NCT03211507)

Eligibility criteria:
For cases

        Inclusion Criteria:

          -  New diagnosis of IPF between February 2017 and October 2019

        Exclusion Criteria:

          -  Unable to give informed consent

          -  Ever worked outside of the UK

        For controls

        Inclusion Criteria:

          -  New outpatient department attendee between February 2017 and October 2019

        Exclusion Criteria:

          -  Unable to give informed consent

          -  Ever worked outside of the UK (does not include work outside the UK by members of the
             armed forces or merchant navy)

          -  Diagnosis of IPF
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Entailment
Clinical trial: Study Evaluating the Impact of Mesh Pore Size on Chronic Pain After Lichtenstein Hernioplasty (NCT02500056)

Eligibility criteria:
Inclusion Criteria:

          -  age ≥18 years

          -  unilateral primary reducible inguinal hernia

          -  elective operation

          -  consent to participate in the study.

        Exclusion Criteria:

          -  age <18 years

          -  irreducible

          -  strangulated

          -  recurrent hernia

          -  inability to understand the questionnaire

          -  unwillingness to participate in the study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: The Efficacy of Severe Whitening and Delayed Fading in Acetic Acid-enhanced Endoscopy for Diagnosing Gastric Intestinal Metaplasia (NCT02806115)

Eligibility criteria:
Inclusion Criteria:

          -  long-lasting upper gastrointestinal symptoms (>15 years)

          -  atrophic gastritis or GIM identified at surveillance endoscopy

        Exclusion Criteria:

          -  presence of advanced adenocarcinoma in the stomach

          -  presence of acute gastrointestinal bleeding

          -  presence of coagulopathy, uncontrolled impaired renal or liver disease

          -  presence of pregnancy or lactation

          -  presence of allergy to acetic acid

          -  age younger than 18 years or older than 80 years

          -  inability to provide written informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Functional Outcomes of Awake vs. Asleep Deep Brain Stimulation (DBS) for Essential Tremor (NCT02418858)

Eligibility criteria:
Inclusion Criteria:

          -  Essential Tremor diagnosed by criteria listed in the Consensus statement of the
             Movement Disorders Society on Tremor

          -  Age 18 - 85 years of age

          -  Motor skills allowing for capability to complete evaluations

          -  Medically cleared for undergoing anesthesia and DBS surgery

        Exclusion Criteria:

          -  Dementia per DSM-V criteria

          -  Medical or other condition precluding MRI

          -  History of supraspinal CNS disease other than Essential Tremor

          -  Alcohol use of more than 4 drinks per day

          -  Pregnancy

          -  History of suicide attempt

          -  Currently uncontrolled clinically significant depression (BDI>20)

          -  History of schizophrenia, delusions, or currently uncontrolled visual hallucinations
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Care Management for Patients With Alzheimer Disease and Their Family Caregivers (NCT00246896)

Eligibility criteria:
Inclusion Criteria:

          -  Alzheimers Disease

        Exclusion Criteria:

          -  Inability to understand English

          -  No telephone
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: No Need for Neuromuscular Blockade in Daycase Laparoscopic Surgery (NCT02782832)

Eligibility criteria:
Inclusion Criteria:

          -  patients undergoing laparoscopic cholecystectomy, umbilical and inguinal hernia repair

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Mirena Extension Trial (NCT02985541)

Eligibility criteria:
Inclusion Criteria:

          -  Signed and dated informed consent

          -  Women, 18 to 35 years of age at the time of screening (visit 1) who are currently
             using Mirena for contraception or for contraception and heavy menstrual bleeding. The
             duration of use of the current Mirena has to be at least 4 years 6 months at the start
             of screening phase but not more than 5 years at visit 2 and the woman is willing to
             continue with its use and has a continuing need for contraception.

          -  Normal or clinically insignificant cervical smear not requiring further follow up

        Exclusion Criteria:

          -  Menopausal symptoms with Follicle-stimulating hormone>30 mIU/ml

          -  Pregnancy or suspicion of pregnancy

          -  Uterine bleeding of unknown etiology

          -  Untreated acute cervicitis or vaginitis or other lower genital tract infections

          -  Increased susceptibility to pelvic infection

          -  Acute pelvic inflammatory disease (PID) or a history of PID unless successfully
             treated and which, in the investigator's opinion, has not negatively affected
             subject's fertility

          -  Congenital or acquired uterine anomaly if it distorts the uterine cavity

          -  History of, diagnosed or suspected genital or other malignancy and untreated cervical
             dysplasia

          -  Any active acute liver disease or liver tumor (benign or malignant)

          -  Clinically significant endometrial polyp(s)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Safety and Efficacy of Repeated Administrations of NurOwn® in ALS Patients (NCT03280056)

Eligibility criteria:
Inclusion Criteria:

          -  ALS diagnosed as possible, laboratory-supported probable, probable, or definite as
             defined by revised El Escorial criteria.

          -  Having onset of ALS disease symptoms, including limb weakness within 24 months at the
             Screening Visit.

          -  ALSFRS-R ≥ 25 at the screening Visit.

          -  Upright slow vital capacity (SVC) measure ≥ 65% of predicted for gender, height, and
             age at the screening Visit.

          -  Rapid progressors

          -  Participants taking a stable dose of Riluzole are permitted in the study

          -  Citizen or permanent resident of the United States or Canadian citizen able to travel
             to a US site for all follow-up study visits

        Exclusion Criteria:

          -  Prior stem cell therapy of any kind

          -  History of autoimmune or other serious disease (including malignancy and immune
             deficiency) that may confound study results

          -  Current use of immunosuppressant medication or anticoagulants (per Investigator
             discretion)

          -  Exposure to any other experimental agent or participation in an ALS clinical trial
             within 30 days prior to Screening Visit

          -  Use of RADICAVA (edaravone injection) within 30 days of screening or intent to use
             edaravone at any time during the course of the study including the follow up period

          -  Use of non-invasive ventilation (BIPAP), diaphragm pacing system or invasive
             ventilation (tracheostomy)

          -  Feeding tube

          -  Pregnant women or women currently breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Guided Self-help for Families With an Overweight Child (NCT01145833)

Eligibility criteria:
Inclusion Criteria:

          -  child between the ages of 8 & 12

          -  an moderately overweight child with a BMI% between 85-97%

          -  child has a parent willing to participate

          -  child has a parent who can read English at a minimum of a 6th grade level

          -  family who is willing to commit to treatment attendance and attendance at all
             assessments.

        Exclusion Criteria:

          -  Child psychiatric disorder diagnoses (based on parent report)

          -  Child diagnoses of a serious current physical disease (such as diabetes)

          -  Child who is taking medications that may impact their weight

          -  Child with physical difficulties that limit the ability to exercise

          -  Child with an active eating disorder

          -  Child and parent will be moving out of the San Diego County before study completion

          -  Child and/or parent has a modified diet due to religious or socially conscious reasons
             (such as Vegan, vegetarian)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction