araag2/NLI4PR huggingface dataset:
Clinical trial: Feasibility of Multi-modal Physical Therapy in Latino Older Adults With Moderate Knee Osteoarthritis (NCT04219423)

Eligibility criteria:
Inclusion Criteria:

          1. Moderate knee osteoarthritis Defined as Kellgren-Lawrence radiographic level 2 or 3

          2. People who speak Spanish as a primary language

          3. Age 50 or greater

          4. pass a Phone screening: Reports problems with physical performance due to knee:
             Answers yes to 'Are you now limited in any way in any of your usual activities because
             of arthritis or joint?' Reports pain in their knee: Answers 'yes' to have you had pain
             in your knee in last 30 days? Be able to walk inside home without a cane, be able to
             walk ¼ of a block without a cane and be able to go up a flight of stairs without
             assistance from another

        Exclusion Criteria:

          1. Psychiatric or behavioral comorbidity preventing participation in a group exercise
             program

          2. History of lower extremity joint arthroplasty

          3. Morbid obesity defined as body mass index of 40 or greater

          4. Presence of inflammatory arthritic condition

          5. Neurologic involvement impacting functional mobility
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Project Options - The ABC Method (NCT03489356)

Eligibility criteria:
Inclusion Criteria:

          -  scheduled for a skin exam with participating dermatologists

        Exclusion Criteria:

          -  psoriasis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Preferences & Treatment Satisfaction Drivers in Rosacea Patients (NCT02602470)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female patients of at least 18 years of age at index date

          -  At least one prescription for a topical rosacea treatments: Azelaic Acid Gel, Azelaic
             Acid Cream, Metronidazole Gel, Metronidazole Cream, Metronidazole Emulsion,
             Metronidazole Lotion, Brimonidine Tartrate Gel

          -  At least one medical record with a diagnosis code for rosacea (ICD-9: 695.3)

          -  At least 6 months of data history prior to the index date

          -  Had at least one encounter at the Reliant Medical Group within 3 months prior to 01
             January 2015

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: The Knee Usual Care Evaluation Study (NCT01905358)

Eligibility criteria:
Inclusion Criteria:

          -  Age greater than 30 years and less than 80 years

          -  Knee pain for at least 6 weeks

          -  Pain rate greater than or equal to 4/10 on a visual analog scale

          -  Morning stiffness less than 30 minutes

          -  Crepitus on active motion of the knee, bony tenderness, or bony enlargement of the
             knee

          -  Willing and able to consider all medical treatment options used to manage
             osteoarthritis of the knee

          -  No contraindications to knee radiographs or MRI

          -  Willing to participate in a registry

          -  Able to understand and sign a consent

          -  Able to answer registry questions independently

        Exclusion Criteria:

          -  Diagnosis of a systemic rheumatic disease or crystalline arthritis (ie RA, SLE,
             systemic sclerosis, psoriatic arthritis or psoriasis, gout, pseudogout, lyme
             arthritis, reactive arthritis, viral arthritis

          -  pregnant or nursing

          -  unable to give informed consent

          -  contraindication to MRI such as indwelling paemaker or cochlear implant

          -  requirement of metal equipment (such as oxygen)

          -  known claustrophobia

          -  gadolinium allergy

          -  lack of fluency in English. Unfortunately, we do not have the financial resources to
             offer full translation services
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Sensory Basis of Speech Motor Learning (NCT04497428)

Eligibility criteria:
Inclusion Criteria:

          -  right handed adults

          -  no known physical or neurological abnormalities

        Exclusion Criteria:

          -  patients with:

          -  cardiac pacemaker

          -  surgical clips or values on the heart

          -  implants

          -  metal or metallic fragments in any part of the body

          -  pregnancy

          -  claustrophobia

          -  a personal or family history of epilepsy

          -  currently taking antipsychotic drugs

          -  currently taking antidepressant drugs

          -  currently taking antianxiety drugs

          -  history of concussion.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Analgesic Efficacy of Erector Spinae Plane Block for Laparoscopic Inguinal Hernia Repair (NCT04131985)

Eligibility criteria:
Inclusion Criteria:

          -  Inguinal hernia disease

        Exclusion Criteria:

          -  Cardio-respiratory disease

          -  Anti-inflammatory treatment

          -  Cognitive disorders

          -  Written consent form haven't get

          -  history of relevant drug allergy

          -  infection of the skin at the site of needle puncture area

          -  coagulopathy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Spectacles for Patients With Down Syndrome (NCT03367793)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Down syndrome

        Exclusion Criteria:

          -  Nystagmus (Involuntary beating movement of the eyes)

          -  Visually significant media opacities (e.g. cataracts or corneal scars)

          -  Strabismic amblyopia (reduced vision in one eye related to a constant eye-turn)

          -  Anisometropic amblyopia (reduced vision in one eye related to a long-standing
             uncompensated difference in prescription between the two eyes)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Resistance Exercise in Woman With Primary Sjörgen Syndrome. (NCT03130062)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with a diagnosis of PSS - according to the criteria of the American-European
             Society for the classification of Primary Sjögren's Syndrome (Vitali et al., 2002);

          -  Female gender

          -  Aged above 18 years

        Exclusion Criteria:

          -  Patients who had cognitive difficulties, with diagnosis of Secondary Sjögren's
             Syndrome,

          -  A regular physical exercise practitioner or who were practicing physical exercise
             regularly up to 2 months before the interview.

          -  Patients in clinical conditions that prevented the practice of physical exercise
             according to previous medical evaluation, such as decompensated diabetes mellitus,
             decompensated thyroid disease, severe cardiorespiratory diseases, etc. - Use of
             medications that interfere with physical aspects, especially in response to the
             sensation of fatigue.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy and Safety of Turoctocog Alfa for Prophylaxis and Treatment of Bleeding Episodes in Previously Treated Chinese Patients With Haemophilia A (NCT02938585)

Eligibility criteria:
Inclusion Criteria:

          -  Male patients

          -  Age from 0 years

          -  With the diagnosis of severe congenital haemophilia A (FVIII≤1%)

          -  History of exposure days (ED) to any FVIII products fulfilling the criteria of
             previously treated patients:

          -  Patients of 12 years or above: 100 exposures days (ED) or more

          -  Patients below 12 years: 50 exposure days (ED) or more

        Exclusion Criteria:

          -  Inhibitors to factor VIII (≥0.6 BU) at screening as assessed by central laboratory

          -  Known history of FVIII inhibitors
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Cushing's Disease Complications (NCT02568982)

Eligibility criteria:
Inclusion Criteria:

          -  Cushing's disease diagnosed by complementary explorations according to the National
             Program of Diagnosis and Care of the Cushing 's disease

        Exclusion Criteria:

          -  other cause of Cushing's syndrome

          -  known inherited syndrome having for consequence an hormonal hypersecretion (NEM-1,
             complexe of carney, McCuneAlbright syndrome)

          -  patient does not understand french

          -  life expectancy of less than 6 months

          -  pregnant women

          -  dependent patient
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Entailment
Clinical trial: Prospective Trial Comparing Two Different Polypropylene Meshes for Inguinal Hernias (NCT01825187)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects undergoing laparoscopic repair for the treatment of either single or
             bilateral inguinal hernias

          -  All surgical residents at New Hanover Regional Medical Center

        Exclusion Criteria:

          -  Subjects requiring emergency surgery

          -  Pregnant subjects

          -  Subjects under the age of 18 years of age
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment