araag2/NLI4PR huggingface dataset:
Clinical trial: Infants With Down Syndrome on a Different Surface (NCT04539535)

Eligibility criteria:
Inclusion Criteria:

          -  Infants aged between 3 and 5 months in both groups

          -  Infants without any neurological, genetic or metabolic disorder diagnosis in the
             control group

        Exclusion Criteria:

          -  Infants whose parents did not want to participate study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 9 Weeks old.
Subject must be at most 19 Weeks

Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study of Factor Inhibitors in Adult Patients With Hemophilia and Von Willebrand's Disease in Upper Egypt (NCT04106323)

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed congenital hemophilia A, Christmas disease, and VWD

        Exclusion Criteria

          -  Patients diagnosed with acquired hemophilia

          -  Patients below 18 years

          -  Patients with other bleeding tendencies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of FYU-981 in Hyperuricemia With or Without Gout (NCT02416167)

Eligibility criteria:
Inclusion Criteria:

          -  Hyperuricemic or gout patients

          -  Serum urate level:

        >= 7.0mg/dL in patients with history of gout, or >= 8.0mg/dL in patients with hypertension,
        diabetes or metabolic syndrome, or >= 9.0mg/dL

        Exclusion Criteria:

          -  Gouty arthritis within two weeks before start of study treatment

          -  Secondary hyperuricemia

          -  HbA1c: >= 8.4%

          -  Uric acid-overproduction type in the classification of hyperuricemia

          -  History of, clinically significant cardiac, hematologic and hepatic disease

          -  Kidney calculi or clinically significant urinary calculi

          -  eGFR: < 30mL/min/1.73m^2

          -  Systolic blood pressure: >= 180 mmHg

          -  Diastolic blood pressure: >= 110 mmHg
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study About Lymphocytes Change During Menstrual Cycle in Women of Child-bearing Age (NCT02951832)

Eligibility criteria:
Inclusion Criteria:

          -  Women aged 20-49;

          -  Having a regular menstrual cycle of which the menstrual period is between day 3-7, and
             the period between day 25-35;

          -  Excluding internal and surgical disease (after having variety of physical examination
             such as electrocardiogram/hepatic and renal function/blood routine and urine routine).

        Exclusion Criteria:

          -  Having experienced severe allergies, trauma history and/or operation history within 3
             months;

          -  With a history of mental illness and/or family history of mental illness;

          -  Limb disabled;

          -  Taking medicine within one month;

          -  Suffering major events or having mood swings.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 49 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Long Term Outcomes Following Total Laparoscopic Hysterectomy and Laparoscopic Supracervical Hysterectomy (NCT01289314)

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal women who are referred to the department

          -  benign condition requiring hysterectomy

          -  Dysmenorrohea/cyclic pelvic pain

          -  Informed consent

        Exclusion Criteria:

          -  Women who are unable to communicate in Norwegian language.

          -  Women with a previous history of cervical dysplasia, with cellular changes suggestive
             of dysplasia in preoperative cervical smear.

          -  Women with atypical hyperplasia or malignancy in preoperative endometrial biopsy.

          -  Women with a substantially enlarged uterus requiring abdominal hysterectomy or not
             suitable for TLH (> 12 week amenorrhea).

          -  Women with a concomitant condition requiring uni- or bilateral oophorectomy.

          -  Postmenopausal women.

          -  Women with no dysmenorrohea/cyclic pelvic pain (<1 on a 10-point visual analogue
             scale).

          -  Women with deep infiltrating endometriosis.
Female
No healthy subjects accepted to join the trial.



Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Value of 25 mcg Cortrosyn Stimulation Test (NCT01428336)

Eligibility criteria:
Inclusion Criteria:

          -  hypothalamic-pituitary-adrenal disorders

        Exclusion Criteria:

          -  under 18 or older than 65 years of age
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Entailment
Clinical trial: Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients (NCT03370913)

Eligibility criteria:
Inclusion Criteria:

          1. Males ≥ 18 years of age with hemophilia A and residual FVIII levels ≤ 1 IU/dL as
             evidenced by medical history, at the time of signing the informed consent.

          2. Must have been on prophylactic FVIII replacement therapy for at least 12 months prior
             to study entry.

          3. Treated/exposed to FVIII concentrates or cryoprecipitate for a minimum of 150 exposure
             days (EDs).

          4. No previous documented history of a detectable FVIII inhibitor, and results from a
             Bethesda assay or Bethesda assay with Nijmegen modification of less than 0.6 Bethesda
             Units (BU) on 2 consecutive occasions at least one week apart within the past 12
             months.

        Exclusion Criteria:

          1. Detectable pre-existing antibodies to the AAV5 capsid.

          2. Any evidence of active infection or any immunosuppressive disorder, including HIV
             infection.

          3. Significant liver dysfunction.

          4. Prior liver biopsy showing significant fibrosis.

          5. Evidence of any bleeding disorder not related to hemophilia A.

          6. Platelet count of < 100 x 10^9/L.

          7. Creatinine ≥ 1.5 mg/dL.

          8. Liver cirrhosis of any etiology as assessed by liver ultrasound.

          9. Chronic or active hepatitis B.

         10. Active Hepatitis C.

         11. Active malignancy, except non-melanoma skin cancer.

         12. History of hepatic malignancy.

         13. History of arterial or venous thromboembolic events.

         14. Known inherited or acquired thrombophilia, including conditions associated with
             increased thromboembolic risk, such as atrial fibrillation.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Validation Process for Confirmation of the French Version of the Pediatric Quality of Life Inventory :PedsQLTM. (NCT03513367)

Eligibility criteria:
Inclusion Criteria:

          -  Boys aged 7 to 18, with genomic Duchenne muscular dystrophy whose parents (mother and
             / or father) or direct grandparents do not oppose.

        Exclusion Criteria:

          -  Inability for the child to understand the issues

          -  Absence of direct parents or grandparents

          -  Child receiving antidepressant treatment

          -  Non French speaking child

          -  Duchenne Muscular Dystrophy girls
Male
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 18 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Azoospermia Patients (NCT03991663)

Eligibility criteria:
Inclusion Criteria:

          -  at least three semen evaluations performed on separate occasions, when the seminal
             specimen after centrifugation showed no sperm under the microscope and was then
             diagnosed according to several clinical parameters；

        Exclusion Criteria:

        -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: FODMAPs and Refractory GERD (NCT02471989)

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18

          -  Affiliation to French Social Security

          -  Informed written consent

          -  RDQ score > 3

          -  Abnormal pH-impedance monitoring on PPI twice daily (since 3 months) according to
             normal values published by Zerbib et al (CGH 2013)

        Exclusion Criteria:

          -  Pregnancy or breast feeding

          -  Women of childbearing potential without an effective method of contraception

          -  Person under guardianship

          -  History of thoracic of abdominal surgery (excepted appendectomy and cholecystectomy)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Inhibitor Development in Patients With Hemophilia A Undergoing Surgery (NCT01571934)

Eligibility criteria:
Inclusion Criteria:

          -  Males with mild/moderate hemophilia A (fVIII activity 1-40%)

          -  Planned surgical intervention which is anticipated to require 5 consecutive days of
             fVIII replacement therapy (These can be outpatient or inpatient treatment days.)

          -  Weight >22.5 kg (To assure that volumes of blood to be drawn for study purposes are
             safe.)

        Exclusion Criteria:

          -  Past history of an inhibitor (inhibitor titer >0.4 BU/ml)

          -  HIV infection with CD4 count <400/ul

          -  Currently receiving immunosuppressive medication(s)

          -  Unable to tolerate quantity of blood to be drawn

          -  Current or past diagnosis autoimmune disorder

          -  Current or past diagnosis of immune deficiency disorder other than HIV
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment