araag2/NLI4PR huggingface dataset:
Clinical trial: Evaluation of SCT800 in Prophylaxis Therapy on Previous Treated Patients With Severe Hemophilia A (NCT03815318)

Eligibility criteria:
Inclusion Criteria:

          -  Aged ≥12 years old and ≤65 years old;

          -  Male patients who are clinically diagnosed with severe (laboratory tested FVIII:C <1%)
             hemophilia A, including historical FVIII:C <1%;

          -  Previously received FVIII treatment (prophylactic or bleeding treatment), have the
             relevant records and are verified to have accumulated exposures days( EDs) ≥150 days;

          -  The bleeding treatment records of at least 3 months before screening can be obtained;

          -  Negative FVIII inhibitor assay results (laboratory tested Nijmegen-Bethesda assay
             result <0.6 BU(Bethesda unit)/mL);

          -  The prothrombin time is normal or international normalized ratio (INR) ≤1.5; 7.
             Platelet count ≥100 × 109/L;

        Exclusion Criteria:

          -  Known allergy to recombinant coagulation factor VIII concentrate or any excipient;
             known allergy to bovine, rodent or hamster bovine;

          -  Has a history or family history of blood coagulation factor VIII inhibitor;

          -  Clinical liver function test (glutamic-pyruvic transaminase, glutamic-pyruvic
             transaminase) ≥ three times the upper limit of normal (ULN) or clinical kidney
             function test (blood urea nitrogen, creatinine) ≥ three times the ULN;

          -  Patients clinically diagnosed with active Hepatitis B or Hepatitis C;

          -  Patients with other coagulation dysfunction diseases in addition to hemophilia A;

          -  Patients with severe heart disease, including myocardial infarction and cardiac
             dysfunction of class III or above;

          -  Patients who previously experienced intracranial bleeding;
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: A Database Study to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada (NCT02367222)

Eligibility criteria:
Inclusion Criteria:

          -  The entire population of Manitoba is considered for inclusion.

        Exclusion Criteria:

          -  Individuals less than or equal to 6 months of age;

          -  Having less than one year of insurance coverage before the enrolment period;

          -  Not registered with MH during the enrolment period;

          -  Physician or hospitalization records indicating a diagnosis of any demyelinating
             condition between 1971 (earliest year for which information is available) and the
             index date.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluation of Ultra-portable Ultrasound in General Practice (NCT04127149)

Eligibility criteria:
Inclusion Criteria:

          -  patients age 18 and over

          -  consulting their general practitioner for one of the 8 conditions below

        Exclusion Criteria:

          -  patients who have already received an imagery exam for the acute episode justifying
             the consult

          -  opposition to participate
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Clomiphene in Males With Prolactinomas and Persistent Hypogonadism (NCT00697814)

Eligibility criteria:
Inclusion Criteria:

          -  a minimum follow-up of 6 months under DA therapy with normal serum prolactin or with
             maximum DA dose (3.5 mg/week of cabergoline or 10 mg/day of bromocriptine for at least
             2 months)

          -  serum total testosterone less than 300ng/dl with normal or low LH and FSH levels after
             discontinuing testosterone replacement for at least 2 months.

        Exclusion Criteria:

          -  impossibility to attend scheduled visits and irregular compliance to DA treatment.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Glucocorticoid Receptor Antagonism in Subclinical Cushings (NCT00721201)

Eligibility criteria:
Inclusion Criteria:

          -  Patients will be eligible for inclusion if: they are males and over 18, lack clinical
             features classically associated with Cushing's syndrome; have evidence of excess
             circulating cortisol

        Exclusion Criteria:

          -  Evidence of local or systemic malignancy; overt Cushing's syndrome; severe
             uncontrolled diabetes mellitus or hypertension; pregnancy; clinically significantly
             impaired cardiovascular function (e.g. stage IV cardiac failure); severe liver disease
             (liver enzymes ≥ 3 x the institutional upper limit of normal range); significantly
             impaired renal function (eGFR <30/min); uncontrolled severe active infection;
             treatment with approved or experimental steroidogenesis inhibitors, adrenolytic
             agents, within four weeks of admission; In women, known endometrial cancer, history of
             endometrial hyperplasia or vaginal bleeding of unknown cause; requirement for inhaled
             or systemic glucocorticoids for existing disease; impaired mental capacity or markedly
             abnormal psychiatric evaluation that precludes informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Contradiction
Clinical trial: Online Re-Intervention On Eating Behaviour and BMI On Obese Hypertensive Patients (NCT04580264)

Eligibility criteria:
Inclusion Criteria:

          -  Hypertension.

          -  Overweight or obesity (25 ≤ BMI ≤ 35 kg/m2).

          -  Aged between 18-75 years.

          -  Being a participant of the program 5 years ago.

        Exclusion Criteria:

          -  Not having access to the Internet or lack of information about it.

          -  Treatment with more than 3 antihypertensive drugs.

          -  Meet the criteria of the DSM-IV-TR of a Food Disorder.

          -  Presenting some type of severe psychiatric disorder.

          -  Disability that prevents or hinders physical exercise.

          -  Receiving some treatment for weight loss.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction
Clinical trial: Does Hirschsprung Disease Increase the Risk of Febrile Urinary Tract Infection in Children (NCT04837963)

Eligibility criteria:
Inclusion criteria:

        Patients :

        - surgical treatment of an HD confirmed on histopathologic exam.

        Controls :

        - appendicetomy for acute appendicitis without history of HD, ano rectal malformation or
        any other colic disease

        Exclusion criteria:

          -  patients with HD but not yet operated

          -  patient with a stoma at the time of the study

          -  patient with chronic intestinal pseudo obstruction without HD
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study Evaluating ReFacto® in Hemophilia A Undergoing Major Surgery (NCT00092976)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 6 years

          -  Male previously treated patients (≥150 Exposure Days) with moderate or severe
             hemophilia A (i.e. ≤ 5% FVIII:C) who will undergo elective major surgery that is
             anticipated to require at least 6 consecutive days of daily factor VIII (FVIII)
             infusions (surgical and post-surgical prophylaxis)

          -  Ability to adhere to the protocol requirements

        Exclusion Criteria:

          -  Hypersensitivity to ReFacto, murine allergen, or hamster allergen 2 History of FVIII
             inhibitor or current inhibitor, defined as > 0.6 BU

          -  Prior participation in this study

          -  Any concomitant bleeding disorder other than hemophilia A
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Significance of the Mesh Thickness in the Operation of Inguinal Hernia (NCT00451893)

Eligibility criteria:
Inclusion Criteria:

          -  Male, age 25 years or older

          -  Reducible, unilateral, inguinal hernia (not femoral hernia) that has not been operated
             on before

        Exclusion Criteria:

          -  The patient is not able or do not want to give written informed consent

          -  The patient is not suitable for an operation in local anesthesia

          -  Anticoagulant medication or a known coagulation disorder
Male
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Laparoscopic Inguinal Hernia Repair (NCT02920307)

Eligibility criteria:
Inclusion Criteria:

          -  unilateral hernia

          -  uncomplicated hernia

          -  medical fitness for general anesthesia

        Exclusion Criteria:

          -  unfit for general anesthesia

          -  complicated hernia

          -  uncorrectable coagulopathy

          -  BMI > 35

          -  concomitant pathologies requiring simultaneous surgery

          -  bilateral hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment