araag2/NLI4PR huggingface dataset:
Clinical trial: Comparison of Efficacy, Safety and Costs of Recombinant FVIII Products Between On-demand and Secondary Prophylaxis Groups in Haemophilia A Patients (NCT01817868)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18 years

          -  Severe hemophilia A (FVIII<1%) diagnosis

          -  Prior treatment or ongoing treatment with on-demand or prophylaxis regimens according
             to Turkish guidelines and requirements

          -  Previously treated patients with at least >50 exposure days

          -  Written informed consent signed by patient/legal representative

        Exclusion Criteria:

          -  Currently on immune tolerance treatment

          -  Platelet count < 75,000/mm3

          -  Participation in another study

          -  Existence of inhibitors in the past and in the last currently available blood sample
             prior to study start (Bethesda titer < 0.6 BU/ml)

          -  Existence of inhibitor history in family members who also are diagnosed with
             hemophilia A

          -  Having been on primary prophylaxis as defined in the introduction

          -  Participation in another study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study of OV101 in Individuals With Fragile X Syndrome (NCT03697161)

Eligibility criteria:
Inclusion Criteria:

          -  Is male and 13 to 22 years old (inclusive) at the time of informed consent.

          -  Has a diagnosis of FXS with a confirmed FMR1 full mutation (≥200 CGG repeats).

        Exclusion Criteria:

          -  Concomitant disease or condition that are clinically significant and would limit study
             participation

          -  Clinically significant lab abnormalities or vital signs at the time of screening

          -  History of uncontrollable seizure disorder or seizure episodes within 6 months of
             screening or change in the anticonvulsant pharmacotherapy in the past 3 months.

          -  Unable or does not have a caregiver able to comply with study requirements.

          -  Enrolled in any clinical trial within the 30 days before screening.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 22 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Synovial Fluid Bank From Arthritic Patients (NCT00512343)

Eligibility criteria:
Inclusion Criteria:

          -  Significant joint effusion

        Exclusion Criteria:

          -  Hemorrhagic effusion

          -  Traumatic effusion

          -  Less than 3 ml total of collected fluid (used for routine analysis and culture)

          -  Inability or refusal to consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 95 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison Between Effect of Enoxaparin and Clopidogrel on Improving Pregnancy Rate in ICSI (NCT02696330)

Eligibility criteria:
Inclusion Criteria:

        Age :20-35yrs.

          1. Embryo transfer at 3rd or 5th day after ovum pick up.

          2. The transferred embryos are in the four cell stage ,eight cell stage, sixteen cell
             stage or blastocyst stage.

        Exclusion Criteria:

          1. Age <20 or >35 yrs old.

          2. Chronic medical disease.

          3. Single embryo transfer.

          4. Previous ICSI failure.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: C-GLOVES: the Effectiveness of Compression Gloves in Arthritis (NCT01874067)

Eligibility criteria:
Inclusion Criteria:

          -  experiencing hand pain and swelling

        Exclusion Criteria:

          -  unable to give informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: An Examination of the Efficacy of a Self-Determination Theory and Motivational Interviewing Exercise Intervention (NCT02250950)

Eligibility criteria:
Inclusion Criteria:

          -  participants were were willing to attend an exercise class once a week for 12 weeks,
             were willing to complete questionnaires at baseline and 12 weeks, allowed the
             intervention staff to monitor their attendance at the YMCA for 6 months post
             intervention, and allowed the exercise instructor to create an audio recording of all
             of the intervention sessions.

        Exclusion Criteria:

          -  not have any illnesses that would prevent them from exercising once a week, not be
             pregnant or planning to get pregnant within the next 3 months
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Transverse Abdominis Plane (TAP) Block in Children Undergoing Hydrocelectomy and/or Hernia Repair Surgery (NCT01698268)

Eligibility criteria:
Inclusion Criteria:

          -  Children 2-8 years of age

          -  Elective inguinal hernia repair, inguinal hernia repair with peritoneoscopy and/or
             hydrocelectomy to be performed in the Center for Children's Surgery, Beaumont
             Hospital, Royal Oak

          -  American Society of Anesthesiologists physical status classification 1 and 2 (patients
             that have either no systemic illness, or mild systemic disease that is well
             controlled, eg. mild asthma)

        Exclusion Criteria:

          -  History of allergy to study medications

          -  Enrollment in concurrent research study

          -  Pregnant patients*

          -  Students/trainees/staff*

          -  Mentally disabled/cognitively impaired*
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 8 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Yoga as an Intervention for Women With Knee Osteoarthritis (NCT02146105)

Eligibility criteria:
Inclusion Criteria:

          -  Female - 50 years of age or older

          -  Knee pain on most days of the week

          -  Less than 30 minutes of morning stiffness

          -  Bony enlargement

          -  Bony tenderness to palpation

          -  Signs of inflammation

          -  Able to safely climb 2 flights of stairs without aid

          -  Visited a family physician within the last 12 months

        Exclusion Criteria:

          -  Any other forms of arthritis

          -  Osteoporosis

          -  History of patellofemoral symptoms

          -  Active non-arthritic knee disease

          -  Knee surgery

          -  Use of cane or walking aid

          -  Unstable heart condition

          -  Neurological conditions

          -  Skin allergy to medical tape

          -  Hip or ankle injuries in past 3 months

          -  Any injuries that would prohibit participation in yoga

          -  Ipsilateral hip or ankle conditions

          -  Currently receiving cancer treatment

          -  Currently pregnant
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Randomized Controlled Trial of a Community Health Worker Program on Hearing Loss (Oyendo Bien) (NCT03255161)

Eligibility criteria:
Inclusion Criteria:

          -  Minimum age: 50 years

          -  Audiometrically-confirmed hearing loss

          -  Availability of a communication partner to attend the program with the participant

          -  Be Spanish speaking and able to sign written informed consent

        Exclusion Criteria:

          -  Cognitive impairment
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Association of Beta-2 Adrenergic Agonist and Corticosteroid Injection in the Treatment of Lipomas (NCT00624416)

Eligibility criteria:
Inclusion Criteria:

          -  You are a man or a woman between the ages of 18-60, inclusive.

          -  You have a body mass index (BMI) between 20 and less than 40 kg/m2. BMI is a number
             calculated from your height and weight.

          -  You have a lipoma (a benign fatty tumor) that is 1 inch or more in diameter under the
             skin of your abdomen or on another area of your body that is easily accessible to
             study (such as the thigh).

          -  You have not gained or lost more than 11 pounds in the last 3 months.

          -  Your exercise routine has been stable for the last 3 months or you are sedentary.
             Sedentary means you do less than 60 minutes of exercise per week.

        Exclusion Criteria:

          -  You have a history of heart or blood vessel disease.

          -  Your blood pressure is above 140/90 mmHg.

          -  You have type 1 diabetes.

          -  You have a history of kidney or liver disease.

          -  You have thyroid disease that has not been treated.

          -  You are a smoker.

          -  You use a Beta-2 (B2) adrenergic stimulator (a type of drug used to treat asthma), a
             beta adrenergic blocker (a type of drug used to treat blood pressure) or
             glucocorticoid medications (a type of drug used to treat immune system disease).

          -  You have a problem with alcoholism or other substance abuse.

          -  You are pregnant or breast feeding.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment