araag2/NLI4PR huggingface dataset:
Clinical trial: The Rate of Space Closure With Piezocision-based Corticotomy in Different Facial Types: A Split-mouth Design (NCT04202016)

Eligibility criteria:
Inclusion Criteria:

          -  Young adults and adults (15-29).

          -  Middleastern Caucasian.

          -  Females.

          -  Having the defined orthodontic appliance, slot size, prescription, and technique of
             space closure.

          -  Class II division I of moderate space requirement that is planned to have the first
             premolar extracted.

          -  Average or high facial type.

          -  Healthy patients without systematic diseases that could affect bone and tooth movement
             and no contraindication (medical or psychological) to avoid oral surgery.

          -  No active periodontal diseases as this effect the cytokines expression (stabilized
             prostaglandin (PG) health)

          -  Good oral hygiene.

          -  No other method of non-surgical acceleration technique to be used.

        Exclusion Criteria:

          -  Patients who refused to consent for the study.

          -  The two extremes of age (younger than 14 and older than 29).

          -  Having other than the defined orthodontic appliance, slot size, prescription, and
             technique of space closure.

          -  Extraction cases of high space requirements or other teeth than the first premolar.

          -  Patients with systematic diseases that could affect bone and tooth movement and no
             contraindication (medical or psychological) avoid oral surgery.

          -  Active periodontal diseases.

          -  Other methods of non-surgical acceleration technique to be used.
Female
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 29 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Gonadotropin-Releasing Hormone Pulse Frequency in Sexual Maturation and in the Menstrual Cycle (NCT00004335)

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

        --Disease Characteristics--

          -  Suspected or proven hypothalamic-pituitary-gonadal dysfunction, i.e.: Significant
             short stature and possible hypopituitarism Delayed adolescence Precocious puberty
             Isolated growth hormone deficiency (IGHD)Primary hypogonadism

          -  Women are also studied, including those with the following disorders: Infertility
             Oligo- or amenorrhea Hirsutism

        --Patient Characteristics--

          -  Age: 7 to 16 (18 to 35 for women and volunteers)

          -  Other: No pregnant or nursing women No prisoners Not in neuropsychiatric institute or
             other facility for mental illness
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) (NCT00032890)

Eligibility criteria:
40 years and above, both genders, who have clinical and radiographic osteoarthritis
        symptomatic for at least six months.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: A Prospective Study Comparing Telescopic vs. Balloon Dissection in Single Incision Laparoscopic Inguinal Herniorraphy (SILTELESCOPIC) (NCT01883115)

Eligibility criteria:
Inclusion Criteria:

        - all patients referred with inguinal/femoral hernias

        Exclusion Criteria:

          -  • workers Compensation cases

               -  previous extraperitoneal intervention

               -  unfit for a general anaesthetic

               -  strangulated hernias
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 86 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Endometrial Scratching by Pipelle on Pregnancy Rate in Unexplained Infertility (NCT02084914)

Eligibility criteria:
Inclusion Criteria 1. Women diagnosed to have unexplained infertility aged between 20-35y.

        2. Regular menstruation with the length of the cycle between 21-35 days. 3. Ovulation
        confirmed by appropriately timed mid-luteal progesterone. 4. Fertile semen variables
        (according to world health organization criteria 2010).

        5. Bilateral tubal patency (demonstrated by laparoscopy or hystrosalpingography).

        Exclusion Criteria: 1- Patients aged less than 20 y. or more than 35y 2- Infertile semen
        analysis. 3- Abnormal hormonal profile (FSH level more than 10). 4- Patient diagnosed as
        polycystic ovary (PCO). 5- Medical disorders as hypertention,liver and renal diseases. 6-
        Endocrinal disorders as hyperthyroidism,hypothyroidism and diabetes mellitus.

        7- Pelvic pathology as PID or uterine fibroids. 8- No previous history or planning for IVF.
        9- Unwilling to comply with the protocol. 10- Participation in another clinical trial in
        the last 3 months prior to the start of this study.

        -
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of the Analytical Performance of Different Salivary Self-collection Methods for the Detection of COVID-19 (NCT04550390)

Eligibility criteria:
Inclusion Criteria:

          -  To be at least 18 years of age

          -  To come at hospital for SARS-CoV-2 screening

          -  To be able to receive a nasopharyngeal swab

        Exclusion Criteria:

          -  People under 18 years of age

          -  Inpatient in intensive care

          -  Pregnant or breastfeeding woman

          -  Individual with dry syndrome (Gougerot-Sjögren syndrome)

          -  Taking treatments that reduce salivary volume (anticholinergic activity)

          -  People with a COVID-19 diagnosis confirmed by a molecular biology method >7 days ago

          -  Contraindication to oral swabbing
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: The Hypothalamic-Pituitary-Adrenal (HPA) Axis as an Effector System in Weight Regulation (NCT00688987)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with complete adrenal failure as defined as spontaneous serum cortisol of
             levels less than 5 g/dl after 12 hours without glucocorticoid replacement and peak
             serum cortisol of < 5 g/dl 60 minutes after a 250 g ACTH stimulation test.

          -  Subjects who are at their usual weight (weight stable for at least 1 year)

          -  Subjects on stable replacement doses of any required hormone such as thyroid, sex
             hormones, mineralocorticoid replacement, growth hormone, and hydrocortisone for at
             least 6 months, and 4) have a normal body weight (BMI 19-27 kg/m2).

        Exclusion Criteria:

          -  Possible confounders on body weight and insulin resistance

          -  Age less than 18 to exclude those who might be experiencing alterations in cortisol
             production or weight as a result of adolescent growth.

          -  Subjects who exercise > 30 minutes/day, 3 times a week.

          -  Smokers.

          -  Heavy alcohol drinkers (> 2 drinks/ day).

          -  Subjects with medical diagnosis including diabetes, heart disease, and cancer.

          -  Subjects with psychiatric illness (i.e., depression, psychosis, bipolar,
             schizophrenia; or are taking medications for these disorders).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effectivenes of Family Club Denmark #Strongertogether (NCT03657888)

Eligibility criteria:
Inclusion Criteria:

          -  Family with at least one child 2-12 years old.

        Exclusion Criteria:

          -  Not able to fill out questionnaires in Danish
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Photobiomodulation in Oral Lichen Planus (NCT03320460)

Eligibility criteria:
Inclusion Criteria:

          -  The participants in this study will be male and female (aged over 18 years) diagnosed
             with symptomatic oral lichen planus, based on the clinical and histopathological
             criteria of the World Health Organization (WHO).

        Exclusion Criteria:

          -  Patients with ongoing cancer; pregnant or breastfeeding women; patients with history
             of corticosteroids and nonsteroidal anti-inflammatory treatment in the last one
             months, patients with uncontrolled systemic disease; consumption of illicit drugs; use
             of medication associated with oral lichenoid reactions; amalgam restoration near to
             OLP lesions; epithelial dysplasia in the histopathological examination.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparative Clinical Efficacy and Safety of Coded Polyherbal Medicine for the Management of Arthritis (NCT03506919)

Eligibility criteria:
Inclusion Criteria:

          -  Patients suffering from Arthritis

        Exclusion Criteria:

          -  Patients with Hypertension, Cardiovascular disorders and Kidney disorders were
             excluded
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction