Clinical trial: Prospective Evaluation and Molecular Profiling in People With Gastric Tumors (NCT03027427)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Patients with the following are eligible:

               -  Malignant or non-invasive, neoplastic lesions of the stomach confirmed by
                  histopathology or cytopathology in a CLIA-certified laboratory

        OR

        --Suspicious lesions not yet confirmed, but considered likely to be related to the stomach
        pending further evaluation

        OR

          -  Confirmed, deleterious germline mutation (including but not limited to HDGC, GAPPS)
             known to predispose to gastric tumors;

          -  Confirmed or suspicious heritable gastric malignancy disorder;

          -  Clinically suspicious personal or family medical history of gastric cancer or gastric
             cancer syndrome that warrants genetics evaluation.

               -  Patients with a family history of gastric cancer or suspicion of a heritable
                  gastric malignancy disorder

               -  Patients must have an ECOG performance score of 0-2.

               -  Age greater than or equal to 2 years. Note: Patients greater than or equal to 2
                  and less than or equal to 18 years of age may only participate in research sample
                  collection if the tissue acquisition is performed during a clinically indicated
                  surgical procedure, and the sampling of tissue, blood and urine does not add risk
                  to the clinically indicated procedures.

               -  The patient is a candidate for the clinically indicated medical evaluations that
                  are being offered

               -  Ability of subject, their parents/guardians or legally authorized representative
                  (LAR) to understand and must be willing to sign a written informed consent
                  document.

        EXCLUSION CRITERIA:

        Candidates who do not meet the inclusion criteria.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment