araag2/NLI4PR huggingface dataset:
Clinical trial: Estradiol vs Lysteda in Treatment of Heavy Menstrual Bleeding (NCT01659008)

Eligibility criteria:
Inclusion Criteria:

          -  Age: between 18-45 years old

          -  Hemoglobin concentration: less than or equal to 11.5 g/dL, greater than or equal to
             8.0 g/dL

          -  BMI: less than or equal to 35

          -  Menstrual cycle: previous menstrual cycle interval between 26 to 34 days with less
             than or equal to 10 days of bleeding

          -  Contraception: at least two months from implant removal, or six months from their last
             depo-provera or depo-Lupron injection, or recently(at least 2 months) discontinued
             oral, patch or intravaginal ring contraceptives

          -  On cycle day 1-3 of the current menstrual bleeding episode

        Exclusion Criteria:

          -  NSAID, or aspirin containing medications during the 48 hours preceding the current ER
             visit

          -  Estrogen or progestin treatment during the 30 days preceding the current ER visit

          -  Using Paraguard

          -  Pregnant and or lactating

          -  History of endometrial ablation

          -  Women with thromboembolic disease, or coagulopathy

          -  Women with history of myocardial infarction, or cerebrovascular occlusion

          -  Uncontrolled high blood pressure (blood pressure greater than 150/90)

          -  Sensitivity to estrogen, or tranexamic acid
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Weekly vs Daily Teriparatide Therapy in Severe Postmenopausal Osteoporosis (NCT01760798)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women of age group 50-70 having T score less than -2.5 SD or lower at
             lumbar spine or proximal femur.

        Exclusion Criteria:

          -  Patients with renal dysfunction (serum creatinine >1.5)

          -  Primary and secondary hyperparathyroidism

          -  Secondary osteoporosis

          -  Unexplained elevated ALP (alkaline phosphatase)

          -  History of therapeutic radiation

          -  Active malignancy and patients having implant

          -  Patients who have received i.v. or oral bisphosphonates in their disease course
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparing Clinical Efficacy of One-Week Dual Delayed-Release Dexlansoprazole and Esomeprazole for GERD Grade A and B (NCT03128736)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with clinical symptoms of acid regurgitation, heart burn, or feeling of
             acidity in the stomach, who have Los Angeles Grade A and B erosive esophagitis proven
             by endoscopy were recruited

        Exclusion Criteria:

          -  taking antisecretory agents, such as PPIs and histamine-2 receptor antagonists within
             2 week prior to the endoscopy

          -  coexistence of peptic ulcer or gastrointestinal malignancies

          -  pregnancy

          -  coexistence of serious concomitant illness (for example, decompensated liver cirrhosis
             and uremia),

          -  previous gastric surgery

          -  allergy to dexlansoprazole or esomeprazole

          -  symptom score of a validated questionnaire (Chinese GERDQ) less than 12
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy of Natural Ingredient to Improve the Swallowing Response of Patients With Oropharyngeal Dysphagia (NCT02422576)

Eligibility criteria:
Inclusion Criteria:

          -  Patients aged 55+

          -  Patients showing impaired safety of the deglutition during the V-VST (volume -
             viscosity swallow test): Cough oxygen desaturation ≥3% or voice change.

          -  Neurodegenerative or ischemic/hemorrhagic cerebral cause (stroke) or elderly subjects

        Exclusion Criteria:

          -  Patients radiated for treatment of head and neck cancer Idiosyncrasis

          -  Allergy to food or medication, especially contrast products (iodine)

          -  Major respiratory disease needing oxygen as standard treatment.

          -  Any major and relevant abdominal, head and neck, or chest surgery within the three
             months preceding the study.

          -  Have a high alcohol consumption (more than 2 drinks/day)

          -  Subject who cannot be expected to comply with the study procedures, including
             consuming the test products.

          -  Currently participating or having participated in another clinical trial during the
             month preceding the study

          -  Patients with relevant mucosal damage or with in-mouth irritation

          -  Patients with pacemaker or electrode implants

          -  Epileptic patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Reducing HIV Risk in Urban Women: Soap Opera Videos on Video-Capable Cell Phones (NCT03330522)

Eligibility criteria:
Inclusion Criteria:

          -  Women 18-29 years old

          -  Unprotected vaginal or anal sex with at least one man that they perceive as engaging
             in risky behavior OR

          -  Unprotected vaginal or anal sex with more than 1 man regardless of perceived partner
             risk

          -  Can understand written and spoken English

        Exclusion Criteria:

          -  Women younger than 18 years old

          -  Women older than 29 years old

          -  Cannot understand written or spoken English

          -  Previously participated in the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 29 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study Of Sunitinib In Combination With Cisplatin/Capecitabine Or Oxaliplatin/Capecitabine In Patients With Advanced Gastric Cancer (NCT00555620)

Eligibility criteria:
Inclusion Criteria:

          -  confirmed diagnosis of stomach cancer

          -  advanced stomach cancer of stage IV

          -  adequate blood chemistry, blood counts and kidney function

          -  willing to participate to study requirements and sign an informed consent document

        Exclusion Criteria:

          -  prior chemotherapy for the stomach cancer in its advanced stage

          -  excessive toxicities related to prior therapies

          -  pregnant or breastfeeding patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Patient Computer Dialog in Primary Care (NCT00386776)

Eligibility criteria:
Inclusion Criteria:

          -  Request for an initial appointment with a primary care physician at Beth Israel
             Deaconess Medical Center who has agreed to participate in the study

          -  English as first language

          -  Internet access at home

        Exclusion Criteria

          -  Under 18 years of age
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: The Influence of Hypnotic Medications on Sleep Arousal and Its Effect on Gastroesophageal Reflux (NCT00462137)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects must have had a pH probe test at Thomas Jefferson University between July
             2004 and January 2006 with findings consistent with GERD.

          -  Male or female over the age of 18

        Exclusion Criteria:

          -  Hypersensitivity to zolpidem or any of its components

          -  Pregnancy

          -  History of depression or hypnotic/substance abuse

          -  Prior esophagus or stomach surgery

          -  GI tract motility disorder

          -  Any sleep disorder or contraindications to the use of hypnotic medications.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: EUS-guided RFA for Solid Abdominal Neoplasms (NCT03221335)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years-old or above

          -  Suffering from solid neoplasms of the stomach, liver, kidney or adrenals (<5cm in
             largest diameter) that is indicated for treatment.

          -  Unsuitable for surgery, due to one (or more) of the following items:

               -  ASA score > II*

               -  An alternative advanced malignancy

               -  Unsuitable for surgery upon expert's opinion for any other reason

          -  Healthy individuals who are not keen for surgical resection

          -  Eligible for endoscopic intervention

          -  Written informed consent

        Exclusion Criteria:

          -  Coagulopathy (international normalized ratio >1.3, partial thromboplastin time greater
             than twice that of control), platelet count <50,000x103/uL

          -  Pregnancy

          -  Patients with a poor mental condition or mental retardation, unable to understand the
             nature and possible consequences of the study

          -  Patients unwilling to undergo follow-up assessments

          -  Patients with liver cirrhosis, portal hypertension and/or gastric varices.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Hydroxychloroquine for the Treatment of Patients With Mild to Moderate COVID-19 to Prevent Progression to Severe Infection or Death (NCT04323631)

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients (>18 years)

          -  Confirmed COVID-19 infection by real-time PCR from a respiratory or other body sample
             within 48 hours of testing.

          -  Mild to moderate infection or asymptomatic patients with comorbidities: Symptomatic
             patients with fever >37.9ºC or cough or dyspnea or chest pain, not fulfilling severity
             exclusion criteria. We will include patients regardless of time since symptom onset.
             In addition, we will include asymptomatic patients with comorbidities including
             cardiac, pulmonary, diabetes, chronic renal failure or liver disease hospitalized for
             observation.

          -  Informed consent from patient or legal representative.

        Exclusion Criteria:

          -  Severe infection, defined as need for invasive or non-invasive ventilator support,
             ECMO or shock requiring vasopressor support.

          -  Unable to take oral medication

          -  Known allergy to HCQ or chloroquine

          -  Prolonged QT, defined as QTc ≥450 milliseconds for men and as QTc ≥470 for women

          -  Severely reduced LV function (Ejection fraction<30%)

          -  Retinopathy

          -  Pregnancy or breast feeding

          -  Concomitant treatment with azithromycin, flecainide, amiodarone, digoxin,
             procainamide, propafenone, thioridazine, pimozide.

          -  Chronic chloroquine/ HCQ treatment (within 1 month)

          -  Need for hemodialysis

          -  Participating in another RCT for treatment of COVID-19
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment