araag2/NLI4PR huggingface dataset:
Clinical trial: Breakpoint Analysis of de Novo Apparently Balanced Chromosomal Translocations (NCT01826708)

Eligibility criteria:
Inclusion Criteria:

          -  patient with syndromic psychomotor delay

          -  patient with a apparently balanced de novo chromosomal translocation

          -  patient with health insurance

          -  informed consent signed by patient or by parents or by the legal representative for
             children

        Exclusion Criteria:

          -  patient with an inherited translocation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Ultrasound in Diagnosing Patients With Skin Lesions (NCT03914846)

Eligibility criteria:
Inclusion Criteria:

          -  Candidate with skin lesions.

          -  Signed study-specific informed consent prior to study entry.

        Exclusion Criteria:

          -  Prior surgery or radiotherapy to the area to be treated.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers (NCT04355455)

Eligibility criteria:
Inclusion Criteria:

          -  HV aged between 18 - 60 years

        Exclusion Criteria:

          -  history of psychiatric disease or a positive first degree psychiatric family history

          -  pregnancy or lactation

          -  concomitant administration of any centrally activating medication (anti-depressive
             medication, hypnotics, sedatives, anxiolytics, …)

          -  medication affecting esophageal motility

          -  significant co-morbidities (neuromuscular, psychiatric, cardiovascular, pulmonary,
             endocrine, autoimmune, renal and hepatic)

          -  prior history of esophageal, gastric surgery or endoscopic anti-reflux procedure

          -  history of gastrointestinal disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Contradiction
Clinical trial: Using Bite Counter for Weight Loss: A One-month Usability Trial to Test the Effectiveness of Using the Bite Counter (NCT02494674)

Eligibility criteria:
Inclusion Criteria:

          -  18-65 years of age

          -  BMI between 25- 49.9 kg/m2

          -  live in Columbia, South Carolina area

          -  be able to attend all assessment visits

          -  have access to the Internet, a computer, and a smartphone (iPhone, Android, etc.)

          -  have MD consent for participation if currently on blood pressure medications, have
             issues with dizziness, or have bone or joint issues

          -  be free of an eating disorder as screened by the Eating disorder Screen for Primary
             care. (If a participant has an eating disorder, they will be referred to their family
             physician)

          -  no current participation in a weight loss program or taking weight loss medications
             (although participants may be trying to lose weight on their own)

          -  able to prepare all their own meals (i.e. not living on-campus)

        Exclusion Criteria:

          -  major health or psychiatric diseases, drug or alcohol dependency, thyroid conditions,
             or pregnancy

          -  pregnant (or have been pregnant in the last 6 months), anticipating on becoming
             pregnant in the next 7 months, or currently breastfeeding o Women who are pregnant
             should not be pursuing weight loss and should be under the direct care of a physician.
             Therefore women who are pregnant or who are anticipating they might be pregnant should
             not participate in this study. If a woman becomes pregnant during the study, she will
             be advised to consult her care provider and will be dropped from the weight loss
             study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Vaccine Coverage and Primary Sjögren'Syndrome (NCT04224454)

Eligibility criteria:
Inclusion criteria:

        - patients with pSS according to European-American Diagnostic Criteria

        Exclusion criteria:

        - Refusal to participate
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: The Usage of Soda-Water in Gastric Preparation for Magnetically Controlled Capsule Endoscopy (NCT04479423)

Eligibility criteria:
Inclusion Criteria:

          -  Over 18 years and below 75 years of age

          -  Plan to undergo MCCG examination in Changhai Hospital

        Exclusion Criteria:

          -  dysphagia or symptoms of gastric outlet obstruction, suspected or known intestinal
             stenosis, overt gastrointestinal bleeding, fistulas and strictures;

          -  history of gastrointestinal surgery or suspected delayed gastric emptying;

          -  Implanted metallic devices such aspacemakers, defibrillators, artificial heart valves
             or joint prostheses;

          -  Allergic to high molecular materials such as simethicone and streptozyme;

          -  Pregnancy or mentally ill person;

          -  currently participating in another clinical study;
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Real World Evidence for the Cycle of Neoadjuvant Chemotherapy in Gastric Cancer With Shared Decision Making (NCT03413514)

Eligibility criteria:
Inclusion Criteria:

          1. Histologically proven adenocarcinoma of the stomach

          2. Clinical cT2N+M0,or cT3-4a/N+M0 disease, confirmed by upper gastrointestinal endoscopy
             and abdominal computed tomography (CT) and MRI and laparoscopy.

          3. Receive neoadjuvant chemotherapy in clinical

        Exclusion Criteria:

          1. Contraindication for chemotherapy

          2. Contraindication for surgery

          3. Clinically apparent distant metastasis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Follicle Stimulating Hormone (FSH) to Improve Testicular Development in Men With Hypogonadism (NCT00064987)

Eligibility criteria:
Inclusion Criteria

          -  no history of spontaneous puberty

          -  clinical hypogonadism

          -  infantile testes (< 3 ml)

          -  no reproductive hormone therapy except testosterone

          -  Complete absence of normal LH pulses during 12-hour baseline frequent blood sampling
             and serum testosterone < 100 ng/dl

          -  Normal testing of the anterior pituitary gland

          -  Negative MRI of the hypothalamic-pituitary area

        Exclusion Criteria

          -  Prior therapy with gonadotropins (FSH, hCG, or GnRH)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Feasibility of Re-TREPP in Patients With a Recurrent Inguinal Hernia After Previous TREPP Repair (NCT03411226)

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients who had developed a recurrent inguinal hernia and had undergone a
             re-TREPP.

        Exclusion Criteria:

          -  Children (age <18 years)

          -  Exclusion criterium for long term follow up: no informed consent obtained.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Non-Invasive Electrical Stimulation of the Human Brain (NCT00001216)

Eligibility criteria:
Males and females, ages 18 and over.

        Diverse racial groups.

        Amputees and others with whom we will have no patient-care relationship may also be
        considered to be volunteers.

        Patients will be recruited from those referred to the Human Motor Control Section, NINDS
        who have neurological syndromes that are of interest.

        On rare occasions we may attempt to study children as young as 10 years with TES.

        Individuals without indwelling cardiac lines and pacemakers.

        Patients recruited for study would come from those referred to the EMG laboratory and to
        the Human Motor Control Clinic who would have distinct neurologic syndromes from well
        defined peripheral and central nervous system lesions including hemiplegia from stroke,
        trauma, tumor or focal demyelination (most commonly patients would have hemiplegia from
        stroke), peripheral nerve lesions, amputations, spinal cord injury.

        Normal volunteers, including NIH employees, would be healthy adults without history of
        physical examination evidence of neurologic disease and individuals with different types of
        amputations involving upper and lower extremities.

        Volunteers may also be participants in the electrophysiological protocol (84-N-0196).

        No history of epilepsy.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment