araag2/NLI4PR huggingface dataset:
Clinical trial: Serology COVID-19 From the Cornwall Hospital Union (NCT04363593)

Eligibility criteria:
Inclusion Criteria:

          -  major

          -  having given his or her written consent and being able to consent

          -  For the prospective COVID-19 (+) sub-population : Diagnosis of COVID-19 by RT-PCR
             SARS-CoV-2 (+)

          -  For the retrospectiveCOVID-19 (+) sub-population : Serum stored as part of care in
             patients diagnosed with COVID-19 (+) by an RT-PCR SARS-CoV-2 (+), and no patient
             opposition obtained.

          -  For the prospective COVID-19 (-) sub-population :

        No suggestive clinical picture associated with RT-PCR SARS-CoV-2 (-) or Evocative clinical
        picture with RT-PCR SARS-CoV-2 (-) and negative chest CT scan

          -  For the retrospective COVID-19 (-) sub-population : Serum kept as part of the care
             before the outbreak began, and no opposition from the subject obtained.

          -  For the staff hospital sub-population : The staff members included must be of legal
             age, work at the Cornish Hospital Center and have given their written consent and be
             able to consent.

        Exclusion Criteria:

        -Patients with RT-PCR SARS-CoV-2 (-) but with a chest CT suggestive of COVID-19.

        And for all the patients in different sub-populations :

          -  incapable of consent

          -  refusal to participate

          -  not covered by a social security scheme
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Nutritional Habits, and Coronavirus Disease 2019 (COVID-19) Outcome (NCT04447144)

Eligibility criteria:
Inclusion Criteria:

        - Patients (18 -80 years) with mild to moderate COVID-19 cases consented to home or
        hospital isolation to follow them.

        Exclusion Criteria:

        Severe cases not fulfilling the definition of mild and moderate cases.

        Definition of mild cases according to The Egyptian Ministry Of Health: (MOH)

          1. Age < 60

          2. Temperature <38.5

          3. SaO2 >92%

          4. Heart Rate <110

          5. Respiratory Rate <25 /min.

          6. Neutrophil / lymphocyte ratio on CBC < 3.1

          7. No co-morbidities that necessitates hospital admission: Pregnancy, severe uncontrolled
             Diabetes, Chronic lung disease, Chronic kidney disease, Chronic liver disease, Serious
             heart diseases (arrythmia, Ischemic heart disease, uncontrolled hypertension),
             immunocompromised: prolonged use of corticosteroids and other immunosuppressive drugs/
             organ transplantation/ HIV/ Immunodeficiency, Obesity (BMI > 40) Any patient not
             fulfilling the above mild criteria is considered having moderate disease as well as
             any positive pulmonary imaging findings
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy and Safety of Relacorilant in Patients With Cortisol-Secreting Adrenal Adenomas (NCT04308590)

Eligibility criteria:
Inclusion Criteria:

          -  Shows lack of cortisol suppression

          -  Suppressed or low early-morning ACTH levels

          -  A radiologically confirmed adrenal lesion

          -  Has IGT or DM

          -  Has uncontrolled hypertension

        Exclusion Criteria:

          -  Has severe, uncontrolled hypertension

          -  Has poorly controlled DM

          -  Has significantly abnormal liver test results or severe renal insufficiency

          -  Has uncontrolled, clinically significant hypothyroidism or hyperthyroidism
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Contradiction
Clinical trial: Reflux Disease in Head and Neck Cancer Patients Undergoing Radiation Therapy (NCT00928161)

Eligibility criteria:
Inclusion Criteria:

          1. Signed informed consent.

          2. Head and neck cancer (HNC) Oropharynx cancer (OPC) patients who are adults > 18 years
             of age, dispositioned to receive curative RT with bilateral neck (including) parotid
             irradiation with or without chemotherapy.

          3. Radiation Therapy (3D conformal or IMRT).

        Exclusion Criteria:

          1. Subjects unable to tolerate pH-probe in past.

          2. Subjects currently on proton-pump inhibitor (PPI), daily antacids and daily H2
             antagonists.

          3. Prior history of esophago-gastric surgery.

          4. Symptoms of active gastrointestinal bleeding (melena, hematemesis).

          5. Known hepatic cirrhosis or esophageal varices.

          6. Prior esophageal perforation.

          7. Pregnant or lactating woman. Women of childbearing potential who have not undergone a
             hysterectomy with either a positive or no pregnancy test at baseline. Women / men of
             childbearing potential not using a reliable and appropriate contraceptive method
             (oral, injectable, or implantable hormonal contraceptive; tubal ligation;
             intra-uterine device; barrier contraceptive with spermicide; or vasectomized partner).

          8. Subjects with allergies or sensitivities to proton-pump inhibitors.

          9. Patients who cannot complete study follow-up and compliance with study protocol.

         10. Patients on Plavix (if medically appropriate)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Transepidermal Application of Metilaminolevulinate in Daylight PDT in the Treatment of Photodamaged Skin (NCT03963765)

Eligibility criteria:
Inclusion Criteria:

          -  Both gender;

          -  Fitzpatrick phototypes I - IV;

          -  age between 40 and 75 years;

          -  photodamaged skin with at least 1 lesion of actinic keratosis

        Exclusion Criteria:

          -  Pregnancy and lactation;

          -  photosensitivity;

          -  smoking;

          -  malignant neoplasms;

          -  infections;

          -  immunosuppression;

          -  collagenoses;

          -  any systemic disease or emotional/psychological disorder that could contraindicate the
             procedure.

          -  any topical treatment or interventions for at least three months before the study
             started
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Treatment of Occult Inguinal Hernias (NCT04815707)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 or older

          -  Patients undergoing unilateral laparoscopic inguinal hernia repair, found to have a
             contralateral occult inguinal hernia

        Exclusion Criteria:

          -  Patient has life expectancy of less than 2 years

          -  Patients unlikely to follow-up (e.g. live out of state, unable to be reached by
             phone/e-mail

          -  Non-English and Non-Spanish speakers

          -  Pregnant or breast-feeding patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Physiological Predictors of Clinical Outcomes After Anti-reflux Surgery (NCT03390634)

Eligibility criteria:
Inclusion Criteria:

          -  Males and non-pregnant females over the age of 18 years.

          -  Gastro-oesophageal symptoms in accordance with Montreal criteria49

          -  Patients who had oesophageal physiology testing at Guy's and St Thomas' NHS Foundation
             Trust

          -  Oesophageal manometry based on Chicago classification

          -  24-hour standard pH, impedance-pH and Bravo™

          -  Minimum 6 months post ARS and follow-up at GSTT

          -  Verbal consent over the phone

        Exclusion Criteria:

          -  Patients less than 18 years of age.

          -  Pregnancy at the time of interview

          -  Patients unable to comprehend or answer the questionnaires

          -  Oesophageal physiology tests performed in other centres
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Serum IL-21 Levels in Patients With Pemphigus Vulgaris (NCT03177213)

Eligibility criteria:
Inclusion Criteria:

          -  20 pemphigus vulgaris patients

          -  healthy age and sex matched

        Exclusion Criteria:

          -  - Patients with a history of topical or systemic treatment (corticosteroids,
             intralesional steroid injection, immunosuppressive therapy, anticonvulsants and
             anticancer medications, within 4 weeks of the study.

          -  Patients receiving phototherapy within 6 months of the study .

          -  Patients with a history of diabetes mellitus, anemia, thyroid or parathyroid
             disorders, chronic liver or renal diseases, or atopy .

          -  Patients with known autoimmune diseases or cancer.

          -  Pregnant or lactating women were also excluded from the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Feasibility & Effect of a Tele-rehabilitation Program in Idiopathic Pulmonary Fibrosis (IPF) (NCT03548181)

Eligibility criteria:
Inclusion Criteria:

          -  In order to be eligible to participate in this study, the patient must meet all of the
             following criteria:

        Diagnosis of either definite or possible IPF according to the American Thoracic Society
        (ATS) and European Respiratory Society (ERS) criteria Signed informed consent DLCO ≥ 30%
        predicted and FVC ≥ 50% predicted 6 minute walking test ≥ 150 m Adults ≥ 18 years Being
        clinically stable Absolute decline in DLCO & FVC should be less than 10% in the past 6
        months.

        Exclusion Criteria:

          -  A potential patient who meets any of the following criteria will be excluded from
             participation in this study if:

        Participation in an official rehabilitation program < 4 months before start of the study
        Musculoskeletal disorders Severe cardiac diseases (ejection fraction < 30%, daily angina,
        or otherwise specified by treating cardiologist) Unable to understand informed consent
        Other conditions that hamper the use of tele-rehabilitation Non-Danish speaking.
        Unwillingness to implement the protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Entailment