araag2/NLI4PR huggingface dataset:
Clinical trial: Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children (NCT00494624)

Eligibility criteria:
Inclusion Criteria:

          -  age 3 months to 16 years

          -  hospitalization for expiratory wheezing

          -  written informed consent from the parents

        Exclusion Criteria:

          -  Any chronic disease (other than allergy or asthma), e.g. heart disease, immune
             deficiency, or diabetes

          -  varicella and exposure to varicella if not previously have had it

          -  Systemic glucocorticoid 4 weeks prios to the study

          -  Severe disease that needs treatment in the intensive care unit or oxygen saturation
             below 92% despite of additional oxygen and frequent salbutamol inhalations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.
Subject must be at most 15 Years

Patient description (medical language): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient description (patient's own words): I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Does the patient match the trial criteria? Entailment
Clinical trial: The Role of Referred Pain From the Retro Trochanteric Region in Patients With Knee Pain (NCT02560259)

Eligibility criteria:
Inclusion Criteria:

          -  Knee pain

          -  Failure to understand the pain with more conventional diagnosis

          -  Symptoms and retrotrochanteric pain with examination

          -  Pain relief with retro trochanteric local anaesthetic injection

        Exclusion Criteria:

          -  Mental illness

          -  Failure to cooperate

          -  Not adequate Norwegian language skills

          -  Other well known disease explaining symptoms
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: MOBILE Study - A Study of Bonviva (Ibandronate) Regimens in Women With Post-Menopausal Osteoporosis (NCT00048061)

Eligibility criteria:
Inclusion Criteria:

          -  women 55-80 years of age;

          -  post-menopausal for >= 5 years;

          -  ambulatory.

        Exclusion Criteria:

          -  malignant disease diagnosed within the previous 10 years (except basal cell cancer
             that has been successfully removed);

          -  breast cancer within the previous 20 years;

          -  allergy to bisphosphonates;

          -  previous treatment with an intravenous bisphosphonate at any time;

          -  previous treatment with an oral bisphosphonate within the last 6 months, >1 month of
             treatment within the last year, or >3 months of treatment within the last 2 years.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: The Blood Pressure Effects of Febuxostat in Patients Previously Treated With Allopurinol: A Pilot Study (NCT01701622)

Eligibility criteria:
Inclusion Criteria:

          -  Patients currently treated at the University of Mississippi Medical Center General
             Internal Medicine/Hypertension or Family Medicine Clinics.

          -  Have a diagnosis of gout.

          -  Taking allopurinol at a stable dose for at least 2 months.

        Exclusion Criteria:

          -  Less than 18 years old.

          -  Severe renal impairment defined as CrCl <30 mL/min.

          -  Previous diagnosis of severe hepatic impairment.

          -  Currently taking azathioprine, mercaptopurine, or theophylline.

          -  Pregnant, breastfeeding, or anticipating pregnancy or breastfeeding.

          -  Arm circumference greater than 50 cm.

          -  Change in antihypertensive medication within the previous 2 months.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Polycan in Combination With Glucosamine for Treatment of Knee Osteoarthritis (NCT03717714)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of knee osteoarthritis (OA)

          -  OA ranging from grade 1 to grade 3 by Kellgren and Lawrence system

          -  Agree to participate into the study

        Exclusion Criteria:

          -  OA ranging from grade 4 by Kellgren and Lawrence system

          -  Allergic or contradicted with oral NSAIDs (Meloxicam)

          -  Pregnant and breastfeeding women.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Tennis Elbow Patients Undergoing Closed Therapy Can Easily Cause Tendon Tear (NCT04457024)

Eligibility criteria:
Inclusion Criteria:

          -  All patients with tennis elbows in our hospital

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.




Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Knee Arthritis Treatment With Autologous Fragmented Adipose Tissue and PRP - Comparison of Two Treatment Methods (NCT04321629)

Eligibility criteria:
Inclusion Criteria:

          -  symptomatic knee OA

          -  Kellgren- Lawrence grades I - III OA

          -  no or minimal positive effects of previous conservative treatment (rehabilitation,
             hyaluronic acid injections, steroid injections)

          -  VAS pain level minimum 4 in one knee, VAS pain < 2 in the contralateral knee

        Exclusion Criteria:

          -  Use of local corticosteroids up to three months or hyaluronic acid injections up to
             six months prior to the study

          -  Past or present joint infection

          -  Previous knee arthroscopy surgery up to one year prior to examination

          -  Peripheral inflammatory diseases (rheumatoid arthritis, spondyloarthropathies, etc.)

          -  Total arthroplasty and osteotomy

          -  Ankylosis of the joint

          -  Dermatitis or dermatological disease at the intended injection site

          -  Coexistence of degenerative changes in other limb joints (hip, foot)

          -  Cancer

          -  Oral corticosteroid therapy

          -  Use of medicines that affect blood clotting

          -  Pregnancy or breast-feeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Iron Overload in African Americans (NCT00001455)

Eligibility criteria:
Index subjects as well as male and female first and second degree family members, greater
        than 5 years of age, of index subjects with iron overload.

        In some cases, more distant family members will also be studied.

        No patients less than or equal to 5 years old.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment
Clinical trial: VERTOS-II. Percutaneous Vertebroplasty Versus Conservative Therapy (NCT00232466)

Eligibility criteria:
Inclusion criteria:

          -  age: 50 and older

          -  vertebral fracture: 15-85% height loss

          -  level: thoracic vertebral body 5 (Th 5) or lower

          -  osteopenia (T-score &lt; -1 SD)

          -  back pain for at least no longer than 6 weeks

          -  edema in the vertebrae on MR imaging

        Exclusion criteria:

          -  complete loss of vertebral body height

          -  fracture through or destruction of the posterior vertebral wall

          -  pressure of bone fragments on the spinal cord

          -  osteomyelitis or spondylodiscitis

          -  vertebral column neoplasms

          -  uncorrectable coagulation disorder

          -  medical conditions that would make the patient ineligible for emergency decompressive
             surgery should it be necessary to treat a complication of the procedure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Memory and Fear Study (Fear of Memory Loss Study) (NCT04821960)

Eligibility criteria:
Inclusion Criteria:

          -  55 years of age or older

          -  Elevated dementia-related fear

          -  Able to read/write in English

          -  Willingness to be randomized to intervention group

          -  Willingness to complete three weeks of self-guided intervention, questionnaires, and
             cognitive tests.

          -  Access to a reliable internet connection

        Exclusion Criteria:

          -  Diagnosis of mild cognitive impairment, Alzheimer's Disease, or dementia by a
             healthcare provider.

          -  Impaired cognitive or neurologic function

          -  Unstable medical condition

          -  Severe depression

          -  Current treatment for anxiety or depression

          -  Current participation in another psychotherapy

          -  Current use of psychiatric medication

          -  Current substance use disorder

          -  Inadequate vision or hearing to interact with study materials
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 55 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Contradiction