araag2/NLI4PR huggingface dataset:
Clinical trial: Establishment of a Human Tissue Bank for Studying the Microbial Etiology of Neurodegenerative Diseases (NCT01954875)

Eligibility criteria:
Inclusion Criteria:

          -  aged 18 years and older

          -  patients diagnosed with amyotrophic lateral sclerosis or other neurodegenerative
             disease, and healthy controls

        Exclusion Criteria:

          -  Subjects with acute bacterial infection of the GI tract

          -  Subjects on treatments with antibiotics or probiotics within 28 days prior to sampling
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: A New Treatment Option for Heavy Menstrual Bleeding (NCT01715025)

Eligibility criteria:
Inclusion Criteria:

          -  Women aged 18-50 years having regular menstrual cycles

          -  Women willing to collect all sanitary protection for 6 cycles

          -  Women with no contraindications to use of combined hormonal contraception

          -  Women not using any hormonal contraception or any treatment for HMB

          -  Women who have no demonstrable uterine pathology on pelvic ultrasound

          -  Women who have demonstrated a menstrual blood loss (MBL) >80mls in 2 of 3 menstrual
             periods during the pre-treatment phase will be eligible to enter the treatment phase

        Exclusion Criteria:

          -  Women for whom combined oral contraceptives are contraindicated

          -  Women unwilling to collect all sanitary protection for 6 cycles

          -  Women using hormonal contraception or any treatment for HMB

          -  Women who have demonstrable uterine pathology on pelvic ultrasound

          -  Women who have demonstrated a MBL ≤80mls in 2 of 3 consecutive menstrual periods
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Clinical Trial of Hysteroscopy in Postmenopausal Women to Compare Techniques (NCT01376934)

Eligibility criteria:
Inclusion Criteria:

          -  Women post-menopausal with abnormal uterine bleeding, ultrasound with thick
             endometrial distorted

        Exclusion Criteria:

          -  Women with uterine malformations

          -  Women with mental retardation

          -  Women underwent pelvic radiotherapy
Female
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Prevalence and Predictors of Osteoporosis in the Beijing's Urban Population (NCT01476150)

Eligibility criteria:
Inclusion Criteria:

          -  20 to 79 residents in urban Beijing, China.

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 79 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Long-term Safety and Effectiveness of Growth Hormone With GHD, TS, CRF, SGA , ISS and PWS in Children (NCT01604395)

Eligibility criteria:
Inclusion Criteria:

          -  short stature children aged 2 years or more

          -  children with GHD,TS, CRF, SGA or ISS

          -  written informed consent from the person, person's parent or legal guardian
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Human Cell Line-derived Recombinant Factor VIII (Human-cl-rhFVIII) in Previously Untreated Patients (NCT01712438)

Eligibility criteria:
Inclusion Criteria:

          -  Male patients

          -  Severe Hemophilia A (FVIII:C <1%)

          -  No previous treatment with FVIII concentrates or other blood products containing FVIII

        Exclusion Criteria:

          -  Diagnosis with a coagulation disorder other than Hemophilia A

          -  Severe liver or kidney disease

          -  Concomitant treatment with any systemic immunosuppressive drug
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Role of Lymphocyte Subsets and Laboratory Measurements in COVID-19 Disease (NCT04779359)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of COVID-19 disease.

        Exclusion Criteria:

          -  The patients were excluded patients <18 years age and without confirmed diagnosis of
             disease.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: LTFU for Gene Transfer Subjects With Hemophilia B (NCT00515710)

Eligibility criteria:
Inclusion Criteria

        -Adult subjects who participated in prior intrahepatic AAV2-hFIX16 gene transfer studies

        Exclusion Criteria

          -  Subjects who will not consent for study

          -  Subjects who the investigators believe are not capable of performing endpoints of the
             study
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effect of Biomechanical Correction in Medial Tibiofemoral Joint Osteoarthritis (NCT04324931)

Eligibility criteria:
Inclusion Criteria: • 40-60 years of age paients will be included in this study

          -  BMI (25.1±4.2) kg/m2

          -  Subjects with stiffness and knee pain

          -  Subjects with objection of pain in knee joint that was aggravated by performing 2 or
             more of the following functional activities: prolonged cross sitting, stair assents
             and descent, squatting and kneeling.

          -  Subjects who are willing to take participation

          -  Individuals who obeys the commands properly

          -  Individuals exhibiting the subsequent biomechanical changes on screening

          -  Q angle >12 degree for male and >15 degree for female, femoral anteversion, external
             tibial torsion >15 degree, lack of ≥ 5 degree of knee extension in supine position.

        Exclusion Criteria:

          -  • Knee meniscal injuries or ligament injuries

               -  Lately history of lower limb trauma and surgery

               -  In recent times fracture in lower extremity

               -  In lower extremity metal plantation

               -  Cardio vascular conditions

               -  Patella Dislocation/subluxation

               -  Abnormality in foot or deformity
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction
Clinical trial: GnRH Agonist Versus hCG Trigger in Ovulation Induction With Intrauterine Insemination. (NCT03825445)

Eligibility criteria:
Inclusion Criteria:

          -  Infertile women who were indicated for IUI cycles

          -  bilateral tubal patency

          -  at least one follicle ≥ 18mm in diameter on the day of trigger, and

          -  men with more than five millions total motile sperm after preparation.

          -  Only the first cycles of IUI were studied

        Exclusion Criteria:

          -  No mature follicle

          -  Disagree to be enrolled
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Extended Letrozole Regimen Versus Clomiphene Citrate for Superovulation in Patients With Unexplained Infertility Undergoing Intrauterine Insemination (NCT01232075)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with unexplained infertility

          -  Age between 18 - 37 years

          -  Period of infertility > 1 year

          -  Patent Fallopian tubes detected by hysterosalpingography and/or laparoscopy

          -  Normal basal luteinizing hormone (LH), follicle stimulating hormone (FSH) and
             prolactin concentrations

          -  Normal recent semen analysis (according to World Health Organization criteria)

        Exclusion Criteria:

          -  FSH> 10 IU/L

          -  Irregular menstrual cycles

          -  Polycystic ovary syndrome

          -  Endometriosis

          -  Endocrinologic disorders

          -  Systemic disease contraindicating pregnancy

          -  Previous IUI cycles

          -  liver or kidney diseases
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 37 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction