Clinical trial: Axitinib Pharmacokinetics in Chinese Healthy Volunteers (NCT00919204)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy male and/or female (of nonchildbearing potential) Chinese (individuals
             currently residing in mainland China who were born in China and have both parents of
             Chinese descent) subjects between the ages of 18 and 45 years, inclusive. (Healthy is
             defined as no clinically relevant abnormalities identified by a detailed medical
             history, full physical examination, including blood pressure and pulse rate
             measurement, 12 lead ECG and clinical laboratory tests.)

          -  Body Mass Index (BMI) of 19 to 24 kg/m2; and a total body weight >50 kg (110 lbs). A
             BMI lower limit of 18.5 kg/m2 may be rounded up to 19.0 kg/m2; a BMI upper limit of
             24.5 kg/m2 may be rounded down to 24.0 kg/m2 and will be acceptable for inclusion.

        Exclusion Criteria:

          -  Evidence or history of clinically significant hematological, renal, endocrine,
             pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
             allergic (including drug allergies, but excluding untreated, asymptomatic, seasonal
             allergies at time of dosing) disease or clinical findings at Screening.

          -  Any condition possibly affecting drug absorption (eg, gastrectomy).

          -  Drug dependency, a positive urine drug screen, or alcohol dependency.

          -  History of regular alcohol consumption exceeding 28 or more units per week. (One
             unit=285 mL of beer or 25 mL of spirits or 125 mL of wine).

          -  Use of tobacco- or nicotine-containing products (or a positive urine cotinine test).

          -  Treatment with an investigational drug within 3 months (or as determined by local
             regulations) or 5 half-lives preceding the first dose of study medication.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction