araag2/NLI4PR huggingface dataset:
Clinical trial: Use of Wearable Tech to Increase Physical Activity in Inpatient Rehabilitation for Patients With Chronic Pain (NCT04031092)

Eligibility criteria:
Inclusion Criteria:

          -  taking part in inpatient rehabilitation at Unicare Helefort Rehabilitation center for
             chronic pain.

        Exclusion Criteria:

          -  not having a smartphone (will not be able to access the mobile application).

          -  using a wheelchair (the technology will be not able to measure activity correctly)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: DRIVE Trial (Dialysis Patients' Response to Intravenous [IV] Iron With Elevated Ferritin) (NCT00224081)

Eligibility criteria:
Inclusion Criteria:

          -  Chronic hemodialysis

          -  Elevated serum ferritin with low to normal transferrin saturation (TSAT)

          -  Moderate to severe anemia

          -  Receiving epoetin alfa treatment

        Exclusion Criteria:

          -  Known sensitivity to Ferrlecit®

          -  Medical conditions that would confound the efficacy evaluation

          -  Recent blood transfusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Cardiovascular Status in Adrenal Insufficiency (NCT03426319)

Eligibility criteria:
Inclusion Criteria:

          -  Chronic primary adrenal insufficiency

          -  Adequate hormone replacement therapy (>3 years)

          -  Age >18 years

          -  Patient's informed consent

        Exclusion Criteria:

          -  Hormone replacement therapy with an other glucocorticoid than hydrocortisone

          -  Pharmacotherapy with glucocorticoids

          -  Congenital adrenal hyperplasia

          -  Coronary heart disease

          -  Heart failure

          -  Systemic disease with (potential) cardiac involvement (e.g. amyloidosis, lung
             fibrosis)

          -  Pregnancy

          -  Chronic alcohol abuse

          -  Malignant disease

          -  Arterial hypertension

          -  Chronic renal failure (MDRD <60)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Bone Marrow-Derived Autologous Stem Cells for the Treatment of Duchenne Muscular Dystrophy (NCT03067831)

Eligibility criteria:
Inclusion Criteria:

          -  Age group of 3-25 years

          -  Duchenne muscular dystrophy diagnosed on the basis of clinical presentation

        Exclusion Criteria:

          -  Respiratory Distress

          -  Acute infections such as Human Immunodeficient Virus/Hepatitis B Virus/Hepatitis C
             Virus malignancies

          -  Acute medical conditions such as respiratory infections, fever, hemoglobin less than 8
             bleeding tendency, bone marrow disorder, left ventricular ejection fraction < 30%

          -  Pregnancy or breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 25 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of HT-100 in Duchenne Muscular Dystrophy (NCT01847573)

Eligibility criteria:
Main Inclusion Criteria:

          -  Ambulatory or non-ambulatory

          -  Diagnosis of DMD with confirmation of minimal to no dystrophin

          -  Corticosteroid naive or on therapy for at least 12 months (stable dose and regimen)

        Main Exclusion Criteria:

          -  Recent, substantial change in use of cardiac medications or medications affecting
             muscle function

          -  Inability to undergo magnetic resonance imaging (MRI)

          -  Significantly compromised cardio-respiratory function

          -  Prior treatment with another investigational product in past 6 months
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 20 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Safety and Efficacy Study of IGF-1 in Duchenne Muscular Dystrophy (NCT01207908)

Eligibility criteria:
Inclusion Criteria:

          -  DMD diagnosed with mutational testing and/or complete absence of dystrophin on muscle
             biopsy

          -  Proximal pelvic girdle weakness (Gower's maneuver, difficulty with arising from floor
             and going up steps)

          -  Male

          -  Age > 5 years of age

          -  Bone maturation (assess by bone age x-ray): </= 11 years of age

          -  Daily GC (prednisone or deflazacort) therapy for > 12 months

          -  Ambulatory

          -  Informed consent

          -  Willingness and ability to comply with all protocol requirements and procedures

        Exclusion Criteria:

          -  Current or prior treatment with growth hormone or IGF-1 therapy

          -  Non-ambulatory

          -  Pubertal (based on clinical Tanner staging examination)

          -  Congestive cardiac failure

          -  History of intracranial hypertension

          -  Daytime ventilatory dependence (non-invasive or tracheostomy)

          -  Concomitant therapy - any other medications/supplements that would be considered, in
             the opinion of the investigators, to affect muscle function, need to have been started
             3 months prior to enrollment

          -  Patients enrolled in other clinical drug trials

          -  Any physical or mental conditions which may, in the investigators'opinions, render the
             subject unable to complete the tasks of the study appropriately

          -  There will be no selection by ethnicity
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: TEP Versus Open Repair of Sportsman's Hernia (NCT01876342)

Eligibility criteria:
Inclusion Criteria:

          -  males/females professional or non-professional athletes

          -  age 18-50 years

          -  unilateral or bilateral groin pain lasting > 6 weeks

          -  physical examination and MRI indicating sportsman's hernia

          -  pain above inguinal ligament in the deep inguinal ring

          -  grade I-II edema at pubic symphysis on MRI scan is allowed

        Exclusion Criteria:

          -  patients not willing to participate

          -  inguinal or femoral hernia

          -  MRI reveals other major pathology

          -  former surgery to the actual groin

          -  allergy to polypropylene or other contra-indication to surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Use of COLD-fX to Prevent Respiratory Infections in Community Dwelling Seniors (NCT00240461)

Eligibility criteria:
Inclusion Criteria:

          -  Age 65 years of age and older

          -  current season influenza immunization

          -  available for follow-up visits

          -  willing and able to sign written informed consent

        Exclusion Criteria:

          -  HIV infection

          -  malignancy (under active observation or treatment)

          -  unstable cardiovascular diseases

          -  renal abnormalities (serum creatine >200umol/l)

          -  pulmonary disease (chronic bronchitis, emphysema, or asthma requiring treatment in the
             last 3 months with oral steroids - prednisone >10mg/day, other chronic respiratory
             illness)

          -  acute or active chronic liver disease

          -  neurologic or psychiatric disease (progressive or currently under treatment

          -  active tuberculosis

          -  multiple sclerosis

          -  bleeding disorders

          -  planned surgery over the course of the trial

          -  on immunosuppressive therapy

          -  taking oral steroids at dose = to prednisone 10 mg/day or more

          -  taking phenelzine, pentobarbital, haloperidol, warfarin, heparin

          -  use of natural health products(except the study product and vitamins and minerals with
             a dose <600 mg/day of vitamin E and containing no vitamin K) including echinacea or
             ginseng-containing products (tea, capsules, extracts, tablets)

          -  current alcohol/drug abuse

          -  major surgery in the past 6 months

          -  allergies to ginseng
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Depot Medroxyprogesterone Acetate as Emergency Contraception (NCT03395756)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women of reproductive age (18-39 years old) with BMI 18-30 kg/m2

          -  Regular menses for the last 3 months

          -  Cycle duration 24 to 35 days

          -  Women using copper IUD, sterilization, or barrier methods as current or preferred
             birth control method, and women reporting exclusive sex with women

          -  English- or Spanish-speaking

        Exclusion Criteria:

          -  Any contraindications to progesterone contraception per teh CDC Medical Eligibility
             Criteria (Category 3 or 4)

          -  On medications that can alter, or be altered by, progesterone contraceptive steroid
             hormone (e.g., aminoglutethimide or other anti-steroid medication)

          -  Use of any hormonal contraceptive pill, patch, or vaginal ring in the month prior to
             recruitment

          -  Use of depot-medroxyprogesterone acetate in teh 10 months prior to recruitment

          -  Currently pregnant and/or breastfeeding

          -  History of allergic reaction to depot medroxyprogesterone acetate (rash, urticaria,
             anaphylaxis)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Subcapsular Orchiectomy in Men With Klinefelter Syndrome (NCT01750632)

Eligibility criteria:
Inclusion Criteria:

          -  Klinefelter

          -  15-40 years of age

        Exclusion Criteria:

          -  inability to understand the study
Male
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient description (patient's own words): I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Does the patient match the trial criteria? Entailment