araag2/NLI4PR huggingface dataset:
Clinical trial: The Changes of Ryodoraku and HRV After PPI Treatment in GERD Patients (NCT02149914)

Eligibility criteria:
Inclusion Criteria:

          -  male or female

          -  age of 20-75 years

          -  patients with GERD who have to receive PPIs for four weeks

        Exclusion Criteria:

          -  Suffering from peptic ulcer, gallstones, cancer, and Barrett's esophagus

          -  previously underwent the esophagus, stomach or duodenum surgery

          -  Lactating women or pregnant women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy of Combined Contraceptive Vaginal Ring(NuvaRing)in Women With Idiopathic Menorrhagia (NCT01266759)

Eligibility criteria:
Inclusion Criteria:

          -  Women with heavy menstrual bleeding based on PBAC score over 185 (mean of two control
             cycles)and desire contraception

        Exclusion Criteria:

          -  Menorrhagia of endocrine or systemic origin

          -  other pathology e.g. patients with fibroids of any size, adenomyosis, endometriosis,
             pelvic inflammatory disease.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Biomarkers in Giant Cells Arteritis (NCT02844023)

Eligibility criteria:
Inclusion Criteria:

          -  Patient suffering from giant cells arteritis.

          -  Inclusion while discovery of symptoms, or during relapse.

        Exclusion Criteria:

          -  Healthy volunteer

          -  Treatment with corticosteroid since more than 8 days for a patient suffering from
             giant cells arteritis, exept for patients under corticosteroid for a polymyalgia
             rheumatica.

          -  Other diseases than giant cells arteritis that could introduce an inflammatory
             symptom, especially a tumoral process in progress or a chronic inflammatory disease
             (any other one than giant cells arteritis)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Efficacy Study Comparing 4 Weeks of Treatment With Esomeprazole 20 mg qd and 40 mg qd to Placebo qd in Patients With Heartburn and Sleep Disturbances Associated With Gastroesophageal Reflux Disease (GERD) (NCT00628342)

Eligibility criteria:
Inclusion Criteria:

          -  A history of heartburn or acid regurgitation for 3 months or longer or any history of
             erosive esophagitis.

          -  Nightime heartburn averaging at least 2 or 3 times per week and a history of sleep
             disturbances associated with GERD for 1 month or more.

          -  Nightime heartburn graded as moderate or severe on 3 of the last 7 days of the run-in
             period and sleep disturbances associated with GERD as documented in the run-in diary
             card on at least 3 of the last 7 days of the run-in period..

        Exclusion Criteria:

          -  Any condition other than GERD that is either the primary cause of, or a significant
             contributor to the patients sleep disturbance.

          -  Shift workers who work between 12am (midnight) and 6am.

          -  Sleep medication, antihistamine, benzodiazepine, or anti-anxiety medication use that
             has not been stable for at least 3 months or is not expected to remain stable during
             the patients participation in the study.

          -  Other diseases / conditions as listed in the protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Improving Quality of Osteoporosis Care Through Patient Storytelling (NCT01112098)

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  Age 65 or older

          -  At least one visit with a primary care physician in the previous 12 months

        Exclusion Criteria:

          -  DXA scan in the previous 5 years
Female
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Umifenovir in Hospitalized COVID-19 Patients (NCT04350684)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18

          -  COVID-19 Confirmed Cases (Either RT-PCR or CT Scan Confirmed).

          -  Tympanic Temperature of ≥37.5 AND at least one of the following: Cough, Sputum
             production, nasal discharge, myalgia, headache or fatigue) on admission.

          -  Time of onset of the symptoms should be acute ( Days ≤ 10).

          -  SpO2 ≤ 93%

          -  Respiratory Rate ≥ 22

        Exclusion Criteria:

          -  Refusal to participate expressed by patient or legally authorized representative if
             they are present.

          -  Patients with prolonged QT or PR intervals, Second or Third Degree heart block,
             Arrhythmias including torsade de pointes

          -  Patients using drugs with potential interaction with Umifenovir Hydroxychloroquine,
             Lopinavir/Ritonavir or Interferon-β 1a.

          -  Pregnant or lactating women.

          -  History of alcohol or drug addiction in the past 5 years.

          -  Blood ALT/AST levels > 5 times the upper limit of normal on laboratory results.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Comparison of Two Different Wrist Immobilization Methods (NCT04213352)

Eligibility criteria:
Inclusion Criteria:

          -  Being an office worker between 20-35 years of age

          -  Using a computer for at least 4 hours a day

          -  Working full time for at least 1 year without any upper extremity pathology

        Exclusion Criteria:

          -  Having a body mass index of 30 kg / m2 or more on the day of evaluation

          -  Using muscle relaxants 72 hours before the evaluation

          -  Exercising within the last 48 hours
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Deep Brain Stimulation for the Treatment of Alzheimer's Disease (NCT01559220)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of probable AD according to the National Institute of Neurological and
             Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders
             Association (NINCDS-ADRDA) criteria

        Exclusion Criteria:

          -  Has significant neurological disease, other than Alzheimer's disease, e.g., multiple
             sclerosis, Parkinson's disease and ischemic stroke, or severe brain atrophy or the
             presence of subdural hygromas or subdural hematomas.

          -  Evidence of substance abuse (alcohol or other drug) abuse or dependence during the
             previous 12 months (DSM-IV Criteria).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Laryngeal Mask Insertion Conditions And Hemodynamic Effects (NCT03257800)

Eligibility criteria:
Inclusion Criteria:

          -  ASA physical status I or II who were scheduled to minor elective ambulatory surgery
             (e.g. inguinal hernia, undescended testes, umbilical hernia) performed by experienced
             surgeon under general anesthesia.

        Exclusion Criteria:

          -  patients with full stomach

          -  A history of gastric reflux

          -  A history of convulsions, cardiovascular or neuromuscular disease

          -  Allergies to the study drugs

          -  obese children

          -  suspected difficult airway and hyper-reactive airway disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 8 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE) (NCT03358979)

Eligibility criteria:
Patients:

        Inclusion criteria

          -  18 years and over

          -  Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop
             (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level,
             marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds
             (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes

        Exclusion criteria

          -  Treatment with topical ciclosporin

          -  Autologous serum treatment

          -  Wearer of scleral lenses

          -  Known pregnancy or breastfeeding

        Control subjects:

        Inclusion criteria

          -  18 years and over

          -  Tear Break Up Time > 5 seconds (fluorescein test)

        Exclusion criteria

          -  Wearer of contact lenses

          -  Functional ocular signs

          -  Anomalies of the ocular surface observed during examination with the slit lamp

          -  Fluorescein staining of the ocular surface (cornea, conjunctiva)

          -  Topical ocular treatment

          -  Known pregnancy or breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Contradiction