Clinical trial: Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) (NCT00007189)

Eligibility criteria:
Inclusion Criteria:

          -  Aged 70 years or older.

          -  Family history of parent, brother, or sister who has, or had, serious age-related
             memory loss, senility, dementia, or Alzheimer's disease.

          -  Study partner available to provide information on the cognitive status of the
             participant and to assist with monitoring of trial medications, if needed.

          -  Sufficient fluency in written and spoken English to participate in study visits and
             neuropsychological testing.

          -  Willingness to limit use of the following for the duration of the study: vitamin E (at
             doses greater than 400 IU per day), non-aspirin NSAIDs, histamine H2 receptor
             antagonists (Tagamet, for example), corticosteroids, anti-inflammatory or analgesic
             doses of aspirin (greater than 81 mg per day), Ginkgo biloba extracts

          -  Ability and intention to participate in regular study visits, in the opinion of the
             study physician.

          -  Provision of informed consent.

        Exclusion Criteria:

          -  History of peptic ulcer disease with bleeding or obstruction.

          -  Clinically significant liver or kidney disease.

          -  History of hypersensitivity to aspirin, ibuprofen, celecoxib, naproxen, or other
             NSAIDs.

          -  Use of anti-coagulant medication.

          -  Cognitive impairment or dementia.

          -  Current alcohol abuse or dependence
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 70 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment