Clinical trial: Brain Network Activation in Patients With Movement Disorders (NCT03269201)

Eligibility criteria:
Inclusion Criteria:

          -  For PD: Idiopathic PD patients (according to the UK PD Society brain bank clinical
             diagnostic criteria (bradykinesia plus at least one other cardinal feature of PD, no
             atypical features or secondary cause).

          -  For ET: bilateral, largely symmetrical postural or kinetic tremor involving hand and
             forearms that is visible and persistent. Additional or isolated tremor of the head may
             occur but in the absence of abnormal posturing.

          -  For Parkinson plus syndrome: multiple system atrophy (MSA), progressive supranuclear
             palsy (PSP), corticobasal degeneration (CBD) and dementia with Lewy bodies (DLB).

          -  For NPH: patients exhibiting some or all components of the clinical triad consisting
             of gait disturbance, urinary control disturbance and cognitive impairment as well as
             proof of enlarged ventricular system or hydrocephalus by cranial CT or MRI scans.

          -  For Dystonia: patients exhibiting a movement disorder syndrome in which sustained or
             repetitive muscle contractions result in twisting and repetitive movements or abnormal
             fixed postures. The movements may resemble a tremor. Patients included will be those
             with either idiopathic, toxic or hereditary mechanism.

          -  For Cerebellar ataxia: patients exhibiting impairment of coordination and balance as
             part of an ataxic cerebellar syndrome which is caused by degeneration of the
             cerebellum and its afferent and efferent connections due to various etiologies, such
             as genetic or sporadic neurodegenerative processes or others.

        Exclusion Criteria:

          -  In the investigator's opinion, any unstable or clinically significant condition that
             would impair the participants' ability to comply with study requirements.

          -  Patients with significant psychiatric symptoms or history or treatment with
             neuroleptics.

          -  MMSE <10

          -  Currently with lice or open wounds on scalp.

          -  Significant sensory deficits, e.g., deafness or blindness

          -  Current drug abuse or alcoholism.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment