araag2/NLI4PR huggingface dataset:
Clinical trial: Mexican Initiative of Patients With Osteoarthritis and Rheumatoid Arthritis (IMPACTAR) (NCT02124031)

Eligibility criteria:
Inclusion Criteria:

          -  Patients > 18 years with diagnosis of OA or RA according to the criteria of the
             American College of Rheumatology (ACR).

        Exclusion Criteria:

          -  Patients with precedents of fractures; carrying patients of chronic diseases who limit
             them in the functional capacity.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Aerobic Exercise in Boys With Duchenne Muscular Dystrophy (DMD) (NCT03319030)

Eligibility criteria:
Inclusion Criteria:

          -  Ages 2-17 years old with a confirmed diagnosis of DMD. Has an appointment in MDA
             clinic at the Ann & Robert H. Lurie Children's Hospital of Chicago.

        Exclusion Criteria:

          -  Is less than two years old and does not have a confirmed diagnosis of DMD.
Male

Subject must be at least 2 Years old.
Subject must be at most 17 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Neuropsychobiological Correlates of Sex-steroid Hormone Manipulation in Healthy Women: a Risk Model for Depression (NCT02661789)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women

          -  Regular menstrual cycles (23 -35 days cycle length)

          -  No systemic or intrauterine steroid hormone use

        Exclusion Criteria:

          -  Psychiatric disorder (DSM IV Axis I or WHO ICD-10 diagnostic classification).

          -  Prior or present neurological or other severe medical condition including substance
             abuse.

          -  No drug intake suspected to influence results

          -  Conditions that may increase risk by participating in the study program including
             ovarian cysts

          -  Pregnancy during the last year

          -  Delivery during the last 2 years

          -  Presently wishing to obtain pregnancy

          -  Breast feeding

          -  Not fluent in Danish or severe visual or hearing impairments

          -  Earlier or present learning disabilities

          -  Claustrophobia (due to MRI scans)

          -  Metal implants (excludes MRI)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Prevent Postpartum Hemorrhage in Women With Von Willebrand Disease: The VWD-WOMAN Trial (NCT04344860)

Eligibility criteria:
Inclusion Criteria:

          1. Pregnant females >= 18 years of age

          2. Confirmed VWD, as defined by VWF:RCo < 0.50 IU/dL and previous history of bleeding

          3. Willingness to have blood drawn

          4. Willing to be randomized to one of two treatments at delivery and for 2 days
             postpartum.

          5. Willing to keep a diary for 3 weeks of postpartum bleeding by pictorial assessment
             chart (PBAC) and any blood products, transfusion, or medications taken.

          6. Willing to return at 21 days for final blood draw and review of diary.

        Exclusion Criteria:

          1. Any bleeding disorder other than VWD; or past thrombotic disease of other bleeding
             disorders.

          2. Previous thrombosis, cardiac disease, congestive failure, arrhythmia, hypertension,
             MI, or stroke.

          3. Platelet count < 100,000/ ul.

          4. Past allergic reaction to VWF or tranexamic acid.

          5. Surgery within the past 8 weeks.

          6. Inability to comply with study protocol requirements.

          7. Concomitant use of antiplatelet drugs, anticoagulants, aspirin or NSAIDs.

          8. Treatment with DDAVP, cryoprecipitate, whole blood, plasma or plasma derivatives
             containing substantial quantities of VWF within 5 days of study.

          9. History of renal disease.

         10. Inability to comply with study requirements.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Quantitative Measurement of Nutritional Substrate Utilization in Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT00714220)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of definite or possible ALS by the El Escorial Criteria

          -  No previously known gastrointestinal problems

        Exclusion Criteria:

          -  Patients or controls who have evidence of previous gastrointestinal disease

          -  Patients unable to give informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Utility of Fibroscan in Estimating Hepatic Iron Concentration (NCT02067130)

Eligibility criteria:
Inclusion Criteria:

          -  All adult patients (age 19 or greater) with hereditary anemias requiring chronic blood
             transfusion at St. Paul's Hospital will be invited to participate in this study. The
             majority of patients will be β-Thalassemia Major.

        Exclusion Criteria:

          -  Known Hepatitis B positive

          -  Known Hepatitis C positive

          -  Known HIV positive

          -  Known liver cirrhosis

          -  Known primary liver disease such as Wilson's disease and hereditary hemochromatosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study to Compare the Efficacy and Safety of Intrapleural Doxycycline Versus Iodopovidone for Performing Pleurodesis in Malignant Pleural Effusion (NCT02583282)

Eligibility criteria:
Inclusion Criteria:

          -  recurrent symptomatic malignant pleural effusion, with subjective improvement of
             dyspnea following thoracentesis

        Exclusion Criteria:

          -  history of any allergy to iodine or doxycycline

          -  history of thyroid disorders

          -  failure of lung expansion after insertion of intercostal tube (trapped lung)

          -  presence of air leaks

          -  advanced malignancy with limited predicted life expectancy (<30 days)

          -  failure to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Vascular Effects of Endothelium-Derived Versus Hemoglobin-Transported Nitric Oxide in Healthy Subjects (NCT00001963)

Eligibility criteria:
All volunteer subjects must be between 21 and 75 years of age, in good health, and must
        have provided informed, written consent for participation in this study.

        No subjects with a history or evidence of present or past hypertension (blood pressure
        greater than 145/95 mmHg), hypercholesterolemia (LDL cholesterol greater than 130 mg/dL),
        diabetes mellitus (fasting blood glucose greater than 120 mg/dL), smoking within 2 years,
        cardiac disease, peripheral vascular disease, coagulopathy, or any other disease
        predisposing to vasculitis or Raynaud's phenomenon.

        No volunteer subject will be allowed to take any medication (oral contraceptive agents are
        allowed) or vitamin supplements for at least one month prior to study and will not be
        allowed to take aspirin for one week prior to study.

        Pregnancy testing will be required of all women of reproductive age to exclude current
        pregnancy.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction
Clinical trial: Foreshortened Esophagus and Its Surgical Therapy (NCT00507377)

Eligibility criteria:
Inclusion Criteria:

          -  patients aged > 18 years, undergoing surgery for the treatment of GERD, of massive
             incarcerated hiatus hernia ± GERD, in which a laparotomic, laparoscopic or
             thoracotomic approach is preoperatively indicated.

        Exclusion Criteria:

          -  association of GERD with epiphrenic esophageal diverticulum, collagen diseases,
             undetermined esophageal motility disorders;

          -  redo antireflux surgery, previous surgery on the thoracic and abdominal esophagus and
             stomach, on the diaphragm.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Functional Manifestations of Pressure Changes in the Middle Ear System (NCT01932736)

Eligibility criteria:
Inclusion Criteria:

          -  21-35 years of age

          -  right-handed

        Exclusion Criteria:

          -  left-handedness or ambidexterity

          -  fMRI safety reasons (ferromagnetic material in their bodies, epilepsy, claustrophobia

          -  history of middle ear/tympanic membrane surgery (tympanostomy tubes)

          -  abnormal otoscopic findings and/or tympanometry on physical exam

          -  pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction