araag2/NLI4PR huggingface dataset:
Clinical trial: Safety and Efficacy Study of A Viscoelastic-free Method for Implantable Collamer Lens (ICL) Implantation (NCT03059043)

Eligibility criteria:
Inclusion Criteria:

          -  Documented stable refraction for at least 1 year(within 0.5D)

          -  Best spectacle-corrected visual acuity (BCVA) of 20/40 or better

          -  Clear central cornea

          -  -0.5D to -18.0D of myopic refractive error

          -  Normal anterior chamber depth at least 2.8 mm to endothelium

          -  Endothelial cell density (ECD) more than 2000 cell/mm2

          -  Pupil diameter smaller than 7.0 mm under mesopic condition

          -  Discontinued 3 weeks for hard contact lens and 1 week for soft contact lens wear

        Exclusion Criteria:

          -  Preexisting ocular diseases or conditions other than myopia, evidence of progressive
             or acute ocular disease

          -  Evidence of connective tissue disease or other systemic diseases that may confound the
             results of the study;

          -  Narrow angle of anterior chamber

          -  Pregnant, lactating, or planning to become pregnant during the course of the trial
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Contradiction
Clinical trial: Vitamins and Minerals for Children With Downs Syndrome (NCT00378456)

Eligibility criteria:
Inclusion Criteria:

          -  Under 7 months of age

          -  Trisomy 21

          -  Live in recruitment Area-i.e. London inside M25, in West Midlands or SW England.

          -  One parent speaks English

        Exclusion Criteria:

          -  No life threatening cardiac disease
No condition on gender to be admitted to the trial.


Subject must be at most 7 Months

Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? Entailment
Clinical trial: Oxycodone-naloxone in Relieving Opioid-related Constipation (NCT00412152)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female subjects at lest 18 years or older with pain.

          -  Subjects must report constipation caused or aggravated by opioids.

        Exclusion Criteria:

          -  Females who are pregnant or lactating.

          -  Subjects with evidence of significant structural abnormalities of the gastrointestinal
             (GI) tract (e.g. bowel obstruction, strictures).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Biomechanical Evaluation of Wrist Ligament Injuries: Diagnostic Tool to Detect Wrist Instability (NCT00657072)

Eligibility criteria:
Inclusion Criteria:

          -  patients who have suffered ligamentous injuries to their wrists and have been referred
             to the principal investigator

          -  subject selected to undergo surgery

          -  The ethnicity and racial makeup of the group is similar to the demographics of the
             surrounding referral base

          -  There will be no exclusion of any gender, racial or ethnic group

        Exclusion Criteria:

          -  Pregnant women will not be included because of increased anesthetic risks at surgery.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Sleep Disorders and Their Cardiovascular Correlates in Atahualpa. (NCT01877616)

Eligibility criteria:
Inclusion Criteria: all Atahualpa residents aged 40 years or more -

        Exclusion Criteria: persons not signing the informed consent form

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.


Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? Entailment
Clinical trial: Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM) (NCT02277587)

Eligibility criteria:
Inclusion Criteria:

          -  Previously diagnosed (e.g. more than 6 months ago) primary or secondary adrenal
             insufficiency with a stable daily glucocorticoid substitution dose for at least 3
             months prior to study entry

          -  Signed informed consent to participate in the study

        Exclusion Criteria:

          -  acute primary or secondary adrenal insufficiency

          -  clinical or laboratory signs of significant cerebral, cardiovascular, respiratory,
             hepatobiliary, pancreatic disease

          -  clinically significant renal dysfunction

          -  any medication with agents which could interfere with glucocorticoid kinetics
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Entailment
Clinical trial: Use of Topical NSAID to Reduce Pain in Oral Lichen Planus and Oral Lichenoid Lesions. (NCT03509675)

Eligibility criteria:
Inclusion Criteria:

          -  Speak English

          -  Have a symptomatic form of the disease.

          -  Are at least 18 years of age.

        Exclusion Criteria:

          -  Known or suspected sensitivity to non-steroidal anti-inflammatory medication

          -  History of asthma

          -  History of gastrointestinal ulceration

          -  History of bleeding disorders

          -  Use of anti-inflammatory agents in the last 24 hours

          -  Use of systemic steroid medication in the last 14 days.

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pain Blocking During Drug Administration or Blood Collection With Needles (NCT01166906)

Eligibility criteria:
Inclusion Criteria:

          -  Receiving an injection with a needle

          -  Able to score the pain on a scale of 0-10 using the universal pain assessment tool,
             preferably 7 years of age or older

        Exclusion Criteria:

          -  Current pregnancy

          -  Inability to understand and carry out instruction
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Safety and Pharmacokinetics of Subcutaneous Injection of OCTA101 in Adult Patients With Severe Hemophilia A (NCT04046848)

Eligibility criteria:
Inclusion Criteria:

          1. Severe hemophilia A (<1% FVIII:C) as documented in medical records

          2. Males ≥18 years of age

          3. Subjects who have had ≥150 exposure days (EDs) with a FVIII product

          4. Written informed consent for study participation obtained before undergoing any study
             specific procedures

        Exclusion Criteria:

          1. Previous participation in this trial

          2. Use of an Investigational Medicinal Product within 30 days prior to the first OCTA101
             injection

          3. History of FVIII inhibitors titre ≥0.6 BU/mL defined by medical records

          4. Inhibitors to FVIII (≥0.6 BU/mL) at screening measured by Nijmegen modified Bethesda
             method at central laboratory

          5. Human immunodeficiency virus (HIV) positive subjects with a CD4+ count <200/mL

          6. Clinically significant anemia at screening (hemoglobin <8 g/dL)

          7. Presence of any significant comorbidity (at the discretion of the investigator) that
             might confound the interpretation of the study data and/or that might put the patient
             at undue risk by participating in the trial

          8. Any coagulation disorder other than hemophilia A

          9. AST or ALT levels >3 times the upper limit of normal

         10. Creatinine >120 μmol/L

         11. Platelet count <100,000 μL

         12. BMI ≥30 kg/m²
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Single Escalating Dose and Multiple Dose Study of BAY 1093884 in Subjects With Severe Hemophilia Types A or B, With or Without Inhibitors (NCT02571569)

Eligibility criteria:
Inclusion Criteria:

          -  Males with severe congenital Hemophilia A or B defined as <1% FVIII or Factor IX (FIX)
             concentration by measurement at the time of screening or from reliable prior
             documentation

          -  For subjects in Cohorts I-IV, I-SC1 and I-SC2; If history of inhibitors is evident,
             inhibitor titer of ≥5 Bethesda Units (BU) at screening or prior to screening at any
             time from medical records.

          -  Age: 18 to 65 years of age at screening

          -  Body mass index (BMI): 18 to 29.9 kg/m²

        Exclusion Criteria:

          -  Subjects with known bleeding disorders (such as von Willebrand factor [vWF]
             deficiency, FXI deficiency, platelet disorders, or known acquired or inherited
             thrombophilia etc.) other than congenital Hemophilia A or B with or without inhibitors

          -  History of angina pectoris or treatment for angina pectoris

          -  History of coronary and/or peripheral atherosclerotic disease, congestive heart
             failure, disseminated intravascular coagulopathy, or stage 2 hypertension defined as
             systolic blood pressure (SBP) ≥160 mmHg or diastolic blood pressure (DBP) ≥100 mmHg
             even if controlled

          -  History of thrombophlebitis, venous / arterial thromboembolic diseases (particularly
             deep vein thrombosis, pulmonary embolism, stroke, myocardial infarction,
             cerebrovascular accident, ischemic heart disease, transient ischemic attack)

          -  Known or suspected hypersensitivity of the immune system, history of anaphylactic
             reaction, known (clinically relevant) allergies, non-allergic drug reactions, or
             multiple drug allergies
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Body Weight Assessment in Swiss Primary School Children: Trend Analysis Over 10 Years (NCT01572935)

Eligibility criteria:
Inclusion Criteria:

          -  age 6-12 years

          -  child is attending one of the selected classrooms

        Exclusion Criteria:

          -  age below 6 or above 12 years
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment