araag2/NLI4PR huggingface dataset:
Clinical trial: MIROCALS: Modifying Immune Response and OutComes in ALS (NCT03039673)

Eligibility criteria:
Main Inclusion criteria

          -  Patient is 18 years old and less than 76 years old

          -  Possible, Probable, Probable laboratory-supported or Definite ALS as defined by El
             Escorial Revised ALS diagnostic criteria

          -  Disease duration <= 24 months

          -  Slow Vital capacity >= 70% of normal

          -  No prior or present riluzole treatment

          -  Lumbar punctures accepted by patient and done

        Main Exclusion criteria

          -  Other neurodegenerative disease that could explain signs or symptoms

          -  Contra indication for lumbar puncture (history of allergy to xylocaine, presence of
             contra-indicated treatment, or coagulation test abnormality, clinically significant
             coagulopathy or thrombocytopenia)

          -  Non authorized treatment

          -  Other disease or disorders that could preclude functional assessment, or
             life-threatening disorders

          -  Any documented, active, past or present, auto-immune disorders except asymptomatic
             Hashimoto thyroiditis

          -  Using assisted ventilation

          -  Feeding through gastrostomy or nasogastric tube

          -  Women of child-bearing potential or sexually active man without contraception

          -  Pregnant or breast feeding woman

          -  Any clinically significant laboratory abnormality (excepting cholesterol,
             triglyceride, glucose, CK, ferritin)

          -  History of documented symptomatic and treated asthma within the past 5 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Paravertebral Block for Inguinal Hernia Repair in Elderly (NCT02537860)

Eligibility criteria:
Inclusion Criteria:

          -  patients admitted to undergo elective unilateral inguinal hernia repair

          -  patients with ASA II, III or IV

        Exclusion Criteria:

          -  bilateral inguinal hernia

          -  incarcerated hernia

          -  emergency cases

          -  known history of allergic reactions to local anesthesia

          -  bleeding disorders

          -  neurological disorders

          -  infection at site of injection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Ambulatory Laparoscopic Inguinal Hernioplasty: Feasibility and Cost Analysis (NCT04504461)

Eligibility criteria:
1. Inclusion Criteria:

               -  Patients older than 18 years old

               -  Laparoscopic inguinal hernioplasty as the pincipal surgery

          2. Exclusion Criteria:

               -  Patients with, high anesthetic risk (decompensated ASA III and ASA IV)

               -  Morbid obesity (higher BMI 40),

               -  Sleep apnea with indication of use of CPAP (Continuous Positive Airway Pressure)

               -  Medicated psychiatric disease,

               -  Drug-dependent patient

               -  Patients with an inadequate social environment-
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops (NCT01850979)

Eligibility criteria:
Inclusion Criteria:

          -  SS was diagnosed according to the SS European Criteria

          -  chronic symptoms of burning, foreign body sensation, itching in both eyes

          -  daily need of artificial tears

          -  abnormal Schirmer (ST) I test < 5mm or rose Bengal staining (RBS) ≥ 4, or break up
             time (BUT) < 5 seconds.

        Exclusion Criteria:

          -  any structural abnormalities (lid scarring, entropion, trichiasis, etc.)

          -  any inflammation or active structural change in the iris or anterior chamber

          -  glaucoma

          -  previous eye surgery or punctual occlusion

          -  use of any other topical medication other than artificial tears

          -  any systemic or topical antibacterial or antiinflammatory drug treatment 90 days
             before study entry

          -  contact lens wearer

          -  the presence of any corneal infection

          -  any corneal diseases (marginal ulcer, opacity, scar, bullous keratopathy,
             conjunctivochalasis, symblepharon or tumor)

          -  pregnancy

          -  change in the immunosuppressive systemic therapy 90 days before study entry
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of an Education Programme for Patients With Osteoarthritis in Primary Care - a Randomized Controlled Trial (NCT00979914)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of osteoarthritis

        Exclusion Criteria:

          -  Must be able to speak and understand swedish
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: A Gene Delivery Study to Evaluate the Safety of and Expression From SRP-9001 in Duchenne Muscular Dystrophy (DMD) (NCT04626674)

Eligibility criteria:
Inclusion Criteria:

          -  Is male at birth, ambulatory and from 4 to under 8 years of age at time of
             randomization.

          -  Definitive diagnosis of Duchenne Muscular Dystrophy based on documented clinical
             findings and prior genetic testing

          -  Ability to cooperate with motor assessment testing.

          -  Stable dose equivalent of oral corticosteroids for at least 12 weeks.

          -  rAAVrh74 antibody titers are not elevated as per protocol-specified requirements.

        Exclusion Criteria:

          -  Has a concomitant illness, autoimmune disease, chronic drug treatment, and/or
             cognitive delay/impairment that in the opinion of the Investigator creates unnecessary
             risks for gene transfer.

          -  Exposure to gene therapy, investigational medication, or any treatment designed to
             increase dystrophin expression within protocol specified time limits.

          -  Abnormality in protocol-specified diagnostic evaluations or laboratory tests.

        Other inclusion/exclusion criteria apply.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 7 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: S-1 and Cisplatin in Treating Patients Who Are Undergoing Surgery for Stage III Stomach Cancer (NCT00182611)

Eligibility criteria:
DISEASE CHARACTERISTICS:

          -  Histologically confirmed gastric adenocarcinoma, including type II or type III
             adenocarcinoma of the esophagogastric junction

               -  Stage III disease

                    -  T3 or T4 and/or N2

                         -  No stage IV disease

               -  Helical CT scan and laparoscopic staging required

          -  Potentially resectable disease

        PATIENT CHARACTERISTICS:

        Age

          -  20 and over

        Performance status

          -  ECOG 0-1

        Life expectancy

          -  Not specified

        Hematopoietic

          -  WBC ≥ 4,000/mm³, but < 12,000/mm³

          -  Granulocyte count ≥ 2,000/mm³

          -  Platelet count ≥ 100,000/mm³

          -  Hemoglobin ≥ 9.0 g/dL

        Hepatic

          -  AST and ALT ≤ 2.5 times upper limit of normal

          -  Bilirubin ≤ 1.5 mg/dL

        Renal

          -  Creatinine clearance ≥ 50 mL/min

        Pulmonary

          -  Arterial oxygen pressure (PaO_2) ≥ 70 mm Hg on room air

        Other

          -  Able to take oral medications

        PRIOR CONCURRENT THERAPY:

        Biologic therapy

          -  Not specified

        Chemotherapy

          -  No prior chemotherapy for gastric cancer

        Endocrine therapy

          -  Not specified

        Radiotherapy

          -  No prior radiotherapy for gastric cancer

        Surgery

          -  No prior surgery for gastric cancer

        Other

          -  No other prior therapy for gastric cancer
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Phase II Randomized Trial of Bethesda Protocol Compared to Cambridge Method for Detection of Early Stage Gastric Cancer in CDH1 Mutation Carriers (NCT04535414)

Eligibility criteria:
-  INCLUSION CRITERIA:

        Initial Enrollment:

        -An individual who harbors a pathogenic, or likely pathogenic, CDH1 germline variant.

        Note: individuals with CDH1 variant classified as any of the following are not eligible:

          -  variant of uncertain significance

          -  benign

          -  likely benign.

               -  Age greater than or equal to 18 years.

               -  Physiologically able to undergo upper endoscopy.

               -  Ability of subject to understand and the willingness to sign a written informed
                  consent document.

        EXCLUSION CRITERIA:

          -  Known bleeding disorder or thrombocytopenia that is a contraindication to endoscopic
             biopsy.

          -  Unstable angina or recent (within 3 months) myocardial infarction.

          -  Any clinical contraindication to general anesthesia.

        Re-Enrollment:

        INCLUSION CRITERIA:

          -  Subject must have previously been enrolled on the study and must have undergone
             endoscopy. Note: Subject may re-enroll only once after initial endoscopy performed

          -  Subject must have clinical need for a repeat endoscopy

          -  Prior on-protocol endoscopy must have occurred at least 6 months (+/- 2 weeks) and no
             greater than 18 months (+/- 4 weeks)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Validation of the Aktiia SA PulseWatch OBPM Device at the Wrist Against Invasive Blood Pressure Measurements (NCT03837769)

Eligibility criteria:
Inclusion criteria:

          -  Age ≥ 18 years

          -  No significant non-invasive systolic blood pressure difference between left arm and
             right arm (difference <20mmHg in systolic arterial pressure)

          -  Patient requires continuous monitoring of diastolic and systolic blood pressure
             continuously via a radial arterial line;

          -  Patient information and informed consent is obtained following the procedures
             described in CIP

        Exclusion criteria:

          -  Arrythmias: tachycardia (resting heart rate > 120/min) at time of study inclusion

          -  Atrial fibrillation

          -  Psychomotor agitation

          -  Significant bruises or trauma on forearm

          -  Intravenous canula around the wrist with impossibility to place the device (Aktiia
             OBPM PulseWatch) around the wrist
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction