araag2/NLI4PR huggingface dataset:
Clinical trial: Relationship Between Gastric Accommodation, TLESRs and Reflux in HV and in GERD With or Without Overlapping Dyspepsia (NCT03788109)

Eligibility criteria:
Inclusion Criteria:

          -  GERD patients:

               -  typical symptoms of reflux, such as heartburn and/or regurgitation;

               -  gastro-esophageal reflux assessed by 24-h pH-impedance monitoring or a positive
                  symptom association or;

               -  esophagitis assessed by upper GI endoscopy with careful evaluation of the
                  presence and extent of a hiatal hernia (HH).

          -  GERD/FD overlap:

               -  FD symptoms according to the Rome III criteria. The symptoms of FD include one or
                  more of: bothersome postprandial fullness occurring after normal sized meals,
                  early satiation that prevents finishing a regular meal, epigastric pain, and
                  epigastric burning at least several times per week during the last 6 months.

        Exclusion Criteria:

          -  Healthy volunteers:

               -  history of any upper gastrointestinal (GI) symptoms or GI surgery;

               -  psychological disorders;

               -  any drug history;

               -  use of medication altering GI motility;

               -  pregnant or nursing women.

          -  GERD patients:

               -  psychological disorders;

               -  any drug history;

               -  use of medication affecting GI motility;

               -  pregnant or nursing women;

               -  history of GI surgery.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: The Marigot Osteoarthritis Nutritional Intervention (MOANi) Trial (NCT03106584)

Eligibility criteria:
Inclusion Criteria:

        The project will focus on patients with a diagnosis of a mild-moderate KOA (level 1-3
        Kellgren and Lawrence and WOMAC in the lower two quartiles), in the target knee, (Frestedt
        et al., 2008) and a BMI between 20 and 30 kg/m2.

        Exclusion Criteria:

        [1] rheumatoid arthritis [2] gout [3] pseudo gout [4] Paget's disease [5] seizure disorder
        [6] insulin dependent diabetes mellitus [7] uncontrolled hypertension [8] unstable
        cardiovascular disease [9] active hepatic or renal disease [10] active cancer and/or HIV
        infection, involved in other clinical trial or experimental treatments in the past 3
        months; pregnant, lactating, or at risk of becoming pregnant; intramuscular/systemic
        corticosteroid injection within 4 weeks; intra-articular corticosteroid injection within 2
        months; or inter-articular hyaluronic acid injection within 4 months prior to enrollment.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 55 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study to Evaluate the Efficacy of Seasonique for the Treatment of Cyclic Pelvic Pain (NCT00196313)

Eligibility criteria:
Inclusion Criteria:

          -  Sexually naïve and agree to abstain from sex during the study

          -  Moderate to severe menstrual-related pelvic pain

          -  Regular spontaneous menstrual cycles

        Exclusion Criteria:

          -  Any contraindication to the use of oral contraceptives

          -  Treatment with an oral contraceptive within the previous 3 months

          -  Previous treatment failure with an extended oral contraceptive regimen
Female
No healthy subjects accepted to join the trial.

Subject must be at most 17 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pilot Investigation of a Multinutrient Supplement on Skin Aging and Aging Metabolites in Healthy Women (NCT00541931)

Eligibility criteria:
Inclusion Criteria:- Fitzpatrick Skin type I or II

          -  Nonpregnant Females, age 18-30 or 50-70

          -  Body Mass Index Normal or Overweight

          -  If age 18-30, must be non-smoker

          -  Willing to fast for 8 hours prior to a blood draw; Exclusion Criteria:- History of
             cosmetic surgery

          -  Use of anti-aging medications within 3 months of enrollment

          -  Use of over-the-counter anti-aging creams (not sunscreens) more than once per week
             within one month of enrollment

          -  Use of dietary supplements including vitamins within one month of enrollment

          -  Use of tanning beds or excessive UV exposure (greater than 2 hours per day) within one
             month of enrollment

          -  Use of sunless tanners within one month of enrollment

          -  Uncontrolled or ongoing serious medical condition

          -  Participation in another clinical study involving use of an investigational drug or
             product

          -  Medical condition which, at the discretion of the investigator, will have a
             significant impact on ability to judge participant's skin characteristics, including
             age.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: CATER: Comprehensive Alveolar and Tooth Esthetic Replacement (NCT04082143)

Eligibility criteria:
Inclusion Criteria:

          -  At least 18 years of age

          -  Willing and able to provide informed consent

          -  In need of one implant to replace a missing tooth

          -  At least 20 teeth in good repair and occlusion

          -  Sufficient bone volume for dental implant placement without required bone augmentation

          -  Site development (soft and/or bone tissue) performed at least 5 months before implant
             placement, when required

        Exclusion Criteria:

          -  Current smoker

          -  Implant cannot be placed without bone graft

          -  Unable to pay for crown

          -  Untreated rampant caries and/or uncontrolled periodontitis

          -  Absence of adjacent (mesial and/or distal) natural tooth

          -  Uncontrolled diabetes

          -  Systemic or local disease or condition that would compromise post-operative healing
             and/or osseointegration

          -  use of bisphosphonates

          -  History of radiation in the head and neck region

          -  Unable or unwilling to return for follow-up visits

          -  Unrealistic esthetic or functional demands

          -  Unlikely to be able to comply with study procedures

          -  Unwilling or unable to provide informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Prepubertal Children With Growth Failure Associated With Primary Insulin-Like Growth Factor-1 (IGF-1) Deficiency (NCT00125164)

Eligibility criteria:
Inclusion Criteria:

          -  Chronological age ≥ 3 and chronological or bone age less than or equal to 11 years
             inclusive in girls;

          -  Chronological age ≥ 3 and chronological or bone age less than or equal to 12 years
             inclusive for boys

          -  Prepubertal

          -  Height SD score of < -2

          -  IGF-1 SD score of < -2

        Exclusion Criteria:

          -  Prior treatment with rhGH, rhIGF-1, or other growth-influencing medications

          -  Growth failure associated with other identifiable causes (e.g., syndromes, chromosomal
             abnormality)

          -  Chronic illness such as diabetes, cystic fibrosis, etc.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Extended vs Flexed Elbow Casting (NCT03935516)

Eligibility criteria:
Inclusion Criteria:

          1. Both bone forearm fractures in which the fracture of the radius and/or ulna is located
             in the proximal one half of the bone

          2. The fracture requires a reduction maneuver

          3. All skeletally immature individuals under the age of 18

          4. Patient aged greater than three years old

          5. Patient or patient's consenting parent/guardian competent in English.

        Exclusion Criteria:

          1. Skeletally mature individuals

          2. Both fractures are located in the distal one-half of the radius and ulna

          3. Isolated fractures of the radius or ulna

          4. The fracture does not require a reduction maneuver

          5. Any nerve or arterial injury in the injured extremity

          6. Humerus fracture on the ipsilateral side

          7. Any open fracture requiring formal surgical debridement

          8. Patient or patient's consenting parent/guardian not competent in English.

          9. Patient or patient's consenting parent/guardian not present.

        9. Severe problems with maintaining follow-up (e.g live in different state) 10.
        Contractures in which applying an extended elbow cast is not possible or practical
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Entailment
Clinical trial: Consequences of Unwanted Pregnancy in Nepal (NCT03930576)

Eligibility criteria:
Inclusion Criteria:

          -  women

          -  seeking pregnancy termination services at one of the study facilities

          -  self-report last menstrual period to be at least 10 weeks ago or not know her
             gestational age

          -  15 years old or older

          -  live in Nepal

        Exclusion Criteria:

          -  under 15 years old

          -  not pregnant

          -  do not live in Nepal
Female
Accepts Healthy Volunteers
Subject must be at least 15 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Entailment
Clinical trial: Endometrial Safety Study of a 0.5 mg Estradiol and 2.5 mg Dydrogesterone Combination (NCT00160316)

Eligibility criteria:
Inclusion Criteria:

          -  Amenorrhoea for >= 12 months.

          -  Serum estradiol and FSH level within the postmenopausal range

          -  Baseline endometrial biopsy assessed by light microscopic histological evaluation
             revealing: insufficient endometrial tissue for diagnosis because of insufficient
             available (atrophic) endometrial tissue (not because of an inaccessible cervix) and
             endometrial thickness < 5 mm (double layer) by transvaginal ultrasound, atrophic
             endometrium, secretory endometrium, menstrual type endometrium, proliferative
             endometrium

        Exclusion Criteria:

          -  Previous systemic unopposed estrogen replacement therapy over 6 months or more.

          -  Any estrogen, progestogen, and/or androgen therapy in the last four weeks before
             Screening Visit (Visit 1). The baseline endometrial biopsy should in all cases be
             taken after cessation of the withdrawal bleeding due to previous hormone replacement
             therapy.

          -  History or presence of an estrogen dependent neoplasia (including breast- cancer).

          -  History or presence of malignant neoplasms other than basal or spinal cell carcinoma
             of the skin.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction