araag2/NLI4PR huggingface dataset:
Clinical trial: Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients (NCT04409522)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of COVID-19 based on either ground glass appearance in chest CT scan or
             positive RT-PCR test for COVID-19

          -  Oxygen saturation drop below 93%

          -  Systolic blood pressure drop below 100 or blood pressure drop of 30 mm Hg from the
             patient's previous normal systolic blood pressure

          -  Fever

          -  Dry cough

          -  Positive PCR for COVID-19

          -  Laboratory indices include CRP and ESR indicating COVID-19

        Exclusion Criteria:

          -  Patient dissatisfaction

          -  Existence of drug interactions

          -  Lack of proper conditions for receiving medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 100 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of the Long-term Effects of Exercise on Heath Indicators in Older People (NCT01874132)

Eligibility criteria:
Inclusion Criteria:

          -  Older adults living independently;

          -  medical approval.

        Exclusion Criteria:

          -  Non-smokers;

          -  Non-morbidly obese;

          -  No history of severe hypertension;

          -  No history of falls;

          -  No orthopaedic, neurological, pulmonary, or cardiac problems.
Male
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 79 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Palliative Care and Quality of Life in Idiopathic Pulmonary Fibrosis (NCT03981406)

Eligibility criteria:
Inclusion Criteria:

          -  IPF as diagnosed by chest CT or lung biopsy, and documented by a pulmonologist in the
             patient's medical record

          -  Capacity to provide informed consent

        Exclusion Criteria:

          -  Documented malignancy that would impact mortality within the study enrollment period

          -  Inability to pay for palliative care visit, insurance or personally.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Contradiction
Clinical trial: Role of MRI in Evaluation of Non-traumatic Causes of Painful Elbow (NCT03182127)

Eligibility criteria:
Inclusion Criteria:

          1. Clinical diagnosis of elbow pain not related by trauma.

          2. Cases with self-reported history of overuse, infection, autoimmune disease, bleeding
             tendency and neoplasm of bone, joint, soft tissue at elbow.

        Exclusion Criteria:

          1. Recent acute traumatic cases.

          2. Cases not fulfilling MRI criteria(contraindicated for MRI): metal implant (pacemaker,
             artificial valve prosthesis ,implantable cardiovascular defibrillator, nerve
             simulator, intro-ocular implant, cochlear implants, arterial clips, bullets or metal
             fragments, swan-guns catheter).

          3. Pregnancy and breast milk feeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Entailment
Clinical trial: Study Utilizing Rilonacept in Gout Exacerbations (NCT00855920)

Eligibility criteria:
Inclusion Criteria:

          1. Male or female 18 - 70 years of age

          2. Previously met the preliminary criteria of ARA for the classification of the acute
             arthritis of primary gout

          3. Presenting with an acute attack (flare) of gout within 48 hours of pain onset and pain
             of at least moderate severity

          4. Must have at least 1 on the 0-3 scale for the swelling and the tenderness assessments
             of the gouty index joint

          5. Current presentation of acute gout flare in 3 joints or less

        Exclusion Criteria:

          1. Treatment with any non-steroidal anti-inflammatory drug (NSAIDs) or opiates within 48
             hours prior to baseline assessments. Treatment with long-acting NSAIDs within 1 month
             prior to baseline visit. Treatment with naproxen, meloxicam, nabumetone, celecoxib and
             indomethacin SR within 5 days prior to baseline visit.

          2. Treatment with oral analgesics within 6 hours before baseline assessments. Treatment
             with topical analgesics within 12 hours before baseline assessments

          3. History of NSAID intolerance

          4. Participants with history of chronic, gouty arthritis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Entailment
Clinical trial: Somatosensory Stimulation in Knee Osteoarthritis (NCT02854176)

Eligibility criteria:
Inclusion Criteria:

          -  18 to 45 years.

          -  Unilateral symptomatic KOA.

          -  Patient in waitlist at the Schulthess Clinic for knee arthroplasty.

          -  Patient has mild to average pain levels

          -  Living place: Canton of Zurich or neighbouring Cantons.

          -  Signed written informed consent.

        Exclusion Criteria:

          -  Symptomatic OA in lower extremity joints other than the knee.

          -  Bilateral symptomatic KOA.

          -  Usage of walking aids.

          -  Surgery to the lower limbs in the prior 12 months.

          -  BMI >35 kg/m2.

          -  Disorders that affect visuomotor function.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Anticariogenic Effect of Moringa Oleifera Mouthwash Compared to Chlorhexidine Mouthwash (NCT04575948)

Eligibility criteria:
Inclusion Criteria:

          -  Systemically free as reported by the patients

          -  Minimum of 20 teeth present in the dentition (excluding wisdom teeth);

          -  Clinically healthy gingiva (on intact periodontium)

          -  Dental biofilm-induced gingivitis (plaque induced gingivitis) according to the
             criteria set by the American Academy of Periodontology for classification of
             periodontal diseases and conditions in 2017

          -  Moderate to high caries risk patients

        Exclusion Criteria:

          -  Patients with periodontitis or requiring other immediate dental treatments (within the
             current 6 months)

          -  Subjects on antibiotics within last 6 months

          -  Periodontal therapy for the past 6 months

          -  Pregnant women and lactating mothers

          -  Medically compromised patients

          -  Subjects with tobacco consumption in any form

          -  Subjects wearing partial dentures or having clinically unacceptable restorations or
             bridges

          -  Subjects wearing orthodontic appliances

          -  History of allergy to chemical or any herbal products
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: To Evaluate the Therapeutic Equivalence and Safety of Azelaic Acid 15% Topical Gel (NCT03094403)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy male or non-pregnant female ≥ 18 years-of-age with a clinical diagnosis of
             moderate facial rosacea;

          -  Subjects had to have a definite clinical diagnosis of facial rosacea severity Grade 3
             as per the IGE

        Exclusion Criteria:

          -  Female subjects who were pregnant, nursing, or planning to become pregnant during
             study participation;
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Extension Study of Liposomal Amikacin for Inhalation in Cystic Fibrosis (CF) Patients With Chronic Pseudomonas Aeruginosa (Pa) Infection (NCT01316276)

Eligibility criteria:
Key Inclusion Criteria:

          -  Written informed consent or assent

          -  Subject has completed study TR02-108, and has been compliant with the study protocol

          -  Women of childbearing potential must agree to use reliable methods of contraception
             for the duration of the study

        Key Exclusion Criteria:

          -  Subject met any of the listed criteria for study drug discontinuation in protocol
             TR02-108.

          -  Abnormal laboratory assessments including LFT (≥ 3× upper limit of normal [ULN]),
             serum creatinine (> 2× ULN) and absolute neutrophil count [ANC] (< 1000).

          -  Psychotic, addictive or other disorder limiting the ability to provide informed
             consent or to comply with study requirements.

          -  History of alcohol, medication or illicit drug abuse within the 6 months prior to
             consent.

          -  Smoking tobacco or any substance within 6 months prior to consent or anticipated
             inability to refrain from smoking throughout the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment