araag2/NLI4PR huggingface dataset:
Clinical trial: Treatment of Refractory Gout With ACTH or Methylprednisolone (NCT04808856)

Eligibility criteria:
Inclusion Criteria:

          -  (123 items and 1 item from 4-7 are met simultaneously) :

               1. Meet the 2015 ACR/EULAR classification diagnostic criteria for gout

               2. Acute gouty arthritis

               3. Age ≥18

               4. Repeated attacks and prolonged pain (more than 1 month);

               5. poor response or intolerance to colchicine or NSAIDs;

               6. Liver and kidney dysfunction;

               7. Old age;

        Exclusion Criteria:

          -  1) History of gastrointestinal bleeding and active ulcer 2) The application history of
             glucocorticoids and ACTH in 1 month before screening 3) Pregnancy and lactation 4)
             Drug and alcohol abuse 5) Malignant tumor (treated or untreated within 5 years) 6)
             Mental illness inability to communicate or have language barriers and inability to
             fully understand and cooperate 7) negligent compensatory heart failure, unstable
             angina pectoris, stroke, transient ischemic attack, myocardial infarction, and severe
             arrhythmia occurred within 6 months 8) The investigator did not consider it
             appropriate to participate in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Osteopuncture for Osteoarthritis-Associated Knee Pain & Disability (NCT00417313)

Eligibility criteria:
Inclusion Criteria:

          -  Radiographic evidence of knee OA on a standing AP X-ray

          -  Bilateral knee pain for at least 3 months with pain of at least moderate intensity
             every day or almost every day

        Exclusion Criteria:

          -  Non-ambulatory, or severely impaired mobility (i.e., require the use of a walker)

          -  Folstein Mini-Mental State Examination score of less than 24

          -  Severe visual or hearing impairment

          -  Knee pain due to factors other than OA, e.g. rheumatoid or psoriatic arthritis, gout,
             pseudogout, metastatic cancer

          -  Significant pain in parts of the body other than the knee or acute knee pain

          -  A large knee effusion or severe mechanical instability of the knee

          -  History of corticosteroid injection in the affected knee(s) during the preceding 3
             months

          -  History of hyaluronic acid injection in the affected knee(s) during the preceding 3
             months

          -  Acute or terminal illness

          -  Immune suppression

          -  Anticoagulation therapy

          -  Presence of a pacemaker

          -  Prior acupuncture treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Relationships Among Body Mass Index, Body Balance and Bone Mineral Density in Postmenopausal Women (NCT03280693)

Eligibility criteria:
Inclusion Criteria:

          -  postmenopausal women with ages range from 50 to 60 years

        Exclusion Criteria:

          -  participation in sports

          -  vertebrobasillar insufficiency

          -  poor diet
Female

Subject must be at least 50 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Soft and Hard Tissue Changes After Immediate Single-tooth Replacement (NCT03784430)

Eligibility criteria:
Inclusion Criteria:

          -  a single tooth to be extracted for endodontic failure, fractures, root caries or
             resorption in the maxillary and mandibular area from second premolar to second
             premolar

          -  patient in good systemic health, with no contraindication for oral surgical
             interventions

        Exclusion Criteria:

          -  patients with impaired systemic diseases that will interfere with surgical
             interventions (autoimmune diseases, uncontrolled diabetes)

          -  assumption of bisphosphonate

          -  smoking more than 10 cigarettes a day
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Muscle Strength and Exercise Capacity in Sarcoidosis Patients (NCT00854672)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosed sarcoidosis according to WASOG/ATS/ERS guidelines

        Exclusion Criteria:

          -  not being able to walk
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? Entailment
Clinical trial: Web-based Adherence Information Integrated Nurse-led Monitoring Clinic (NCT04244123)

Eligibility criteria:
Inclusion Criteria:

          -  All patients who receive easypod GH of age 1-14 years will be approached for consent
             to participate in the study. Patients may have any valid cause for short stature.
             These may include children with

          -  isolated growth hormone deficiency

          -  multiple pituitary hormone deficiencies

          -  non-growth hormone deficient conditions such as

          -  Small for gestational age with postnatal failure of height gain

          -  chronic renal failure and

          -  Turner syndrome. Patients will be recruited to the study irrespective of diagnosis and
             will not be stratified by diagnosis at entry to the study. However, in analysis of
             data, subgroup analysis may be performed on groups such as those with isolated growth
             hormone deficiency, dependent on the frequency of recruitment.

        All patients will be identified at the start of the study. A one month period will be
        considered before the study commences to contact families for potential recruitment. Each
        patient will remain in the study for 12 months. The active study duration will be 18 months
        whereby all eligible patients will be recruited and followed up for a 12 month period. This
        period will be followed by a buffer period to gather necessary data for analysis.

        Exclusion Criteria:

          -  Patients on growth hormone treatment but using other growth hormone devices Patients
             who are younger or older than the age limits.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 14 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: The Predictive Factors of Good Clinical Response to Cholinesterase Inhibitors in Alzheimer Disease and Mixed Dementia (NCT02187276)

Eligibility criteria:
Inclusion Criteria:

        - AD diagnosis or AD with CVD according the criteria of National Institute on Aging and the
        Alzheimer's Association workgroup and the National Institute of Neurological and
        Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders
        Association (NINCDS-ADRDA)

        Exclusion Criteria:

          -  Patients with mild cognitive impairment;

          -  Other types of dementia, such as pure vascular dementia, frontotemporal dementia,
             dementia with Lewy bodies, corticobasal degeneration;

          -  Severe dementia (CDR 3)

          -  Those who were already taking ChEI,

          -  If there have not been agreement between the first researcher and the treating
             physician.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 59 Years old.
Subject must be at most 92 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Probiotics as a Prophylaxis to Prevent Clinical Manifestations of Oral Candidosis in Patients With Sjogren's Syndrome (NCT03840538)

Eligibility criteria:
Inclusion Criteria:

          -  primary or scondary Sjogren's syndrome

        Exclusion Criteria:

          -  allergy to milk derivatives previous intake of antifungals
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study of N-acetylcysteine in Patients With COVID-19 Infection (NCT04374461)

Eligibility criteria:
Inclusion Criteria:

          -  Documented COVID-19 infection (either performed on site or documented external report)

          -  Age ≥ 18

        Arm A:

          -  Admission to an intensive care unit at MSK (M-11) and/or receiving mechanical
             ventilation

          -  Absolute lymphocyte count ≤ 1.0/mm3

          -  As the ALC of patients with lymphoid malignancies is unreliable, they may be enrolled
             at the discretion of the treating physician after review of their blood work.

        Arm B:

          -  Arm B:Requiring 2L or more of supplemental oxygen by nasal cannula or higher to
             maintain SpO2 of 95%

        Exclusion Criteria:

        Arm B:

          -  requiring mechanical ventilation or admission to an intensive care unit at MSK (M11)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effects of Memantine and Bupropion on Acute, Reinforcing, and Conditioned Effects of Cigarettes - 1 (NCT00136747)

Eligibility criteria:
Inclusion Criteria:

          -  DSM-IV diagnosis of nicotine dependence with psychological dependence

          -  Smokes at least 15 cigarettes per day for the three months prior to enrollment

          -  Currently not seeking treatment for nicotine dependence

          -  Medically healthy on the basis of physical examination and medical history, vital
             signs, EKG, and laboratory tests

          -  Females must use an effective method of contraception for the duration of the study

        Exclusion Criteria:

          -  DSM-IV diagnosis of abuse or dependence on alcohol or drugs other than nicotine

          -  Current Axis I diagnosis or current treatment with psychotropic medications within the
             three months prior to enrollment

          -  History of schizophrenia or other psychotic disorders, bipolar disorder, or anxiety
             disorders

          -  Currently seeking treatment for nicotine disorders

          -  On parole or probation

          -  History of seizures or head trauma with loss of consciousness, brain contusion, or
             fracture

          -  History of significant recent violent behavior

          -  Blood pressure greater than 150/90

          -  History of eating disorders

          -  History of allergic reaction to any of the study medications

          -  Pregnant
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction