araag2/NLI4PR huggingface dataset:
Clinical trial: Evaluation of Body Iron Stores in Overweight Healthy Volunteers (NCT02304874)

Eligibility criteria:
Inclusion Criteria:

          -  Male,

          -  At least 18 years old

          -  BMI > 25 Kg/m2

          -  Serum ferritin level between 100 et 300 µg/L

          -  Written informed consent

        Exclusion Criteria:

          -  Blood donations in the past two years

          -  Alcohol consumption more than 30 g/day

          -  Inflammatory syndrome (CRP > 10 mg/L)

          -  Inflammatory, dysimmunitary or cancerous disease

          -  Hepatic cytolysis

          -  Transferrin saturation > 45%

          -  Person involved in another clinical trial

          -  Person with a measure of legal protection (guardianship)

          -  Person who reached the annual limit for compensation provided by biomedical research

          -  Hemoglobin < 13 g/dL

          -  Uncontrolled heart failure or coronary insufficiency

          -  Abnormal ECG

          -  Echocardiographic abnormalities contraindicating phlebotomy

          -  Hepatic, renal or respiratory insufficiency

          -  Superficial venous network insufficiency
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Feasibility of a Water-soluble Contrast Application Into Dysphagia Evaluation (NCT03598491)

Eligibility criteria:
Inclusion Criteria:

          -  All the patients who referred for video-fluoroscopic-swallowing study

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Special Survey for Long Term Application (NCT01516229)

Eligibility criteria:
Inclusion Criteria:

          -  Achondroplasia without epiphyseal line closure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 15 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy and Safety of Sirolimus in COVID-19 Infection (NCT04461340)

Eligibility criteria:
Inclusion Criteria:

          -  Adults (˃18 years) COVID-19 positive patients (confirmed by PCR).

          -  Moderate infection ( pneumonia ± leucopenia or lymphopenia ).

        Exclusion Criteria:

          -  Severe or life threatening COVID infection: Severe disease is defined as: dyspnea,
             respiratory frequency ≥ 30/min, blood oxygen saturation ≤ 93%, partial pressure of
             arterial oxygen to fraction of inspired oxygen ratio < 300, and/or lung infiltrates >
             50% within 24 to 48 hours. Life threatening disease is defined as: respiratory
             failure, septic shock, and/or multiple organ dysfunction or failure .

          -  Pregnant or lactating females.

          -  Participation in any investigational clinical study, other than observational, within
             the past 30 days; or plans to participate in such a study at any time from the day of
             enrollment until 30 days post-treatment in the current study.

          -  Allergy or hypersensitivity to sirolimus.

          -  Taking immunosuppressive drugs.

          -  Glomerular filtration rate (GFR) < 30 ml/min by CKD-EPI equation.

          -  liver cirrhosis .

          -  Decompensated heart failure.

          -  known active tuberculosis (TB) or history of incompletely treated TB.

          -  Uncontrolled systemic bacterial or fungal infections.

          -  Drugs that may affect sirolimus level: antifungals, diltiazem, verapamil, nicardipine,
             phenytoin, phenobarbital, rifampicin, carbamazepine.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effect of Woodsmoke on Vascular Function (NCT01495325)

Eligibility criteria:
Inclusion Criteria:

          -  Non-smoking healthy male firefighters or volunteers

        Exclusion Criteria:

          -  Current smoker or regular users of snus

          -  History of lung or ischaemic heart disease

          -  Malignant arrhythmia

          -  Systolic blood pressure >190mmHg or <100mmHg

          -  Renal or hepatic dysfunction

          -  Previous history of blood dyscrasia

          -  Unable to tolerate the supine position

          -  Blood donation within the last 3 months

          -  Recent respiratory tract infection within the past 4 weeks

          -  Routine medication including aspirin and NSAIDs
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Examining The Efficacy Of Scapular Exercises On Pain And Function İn Patients With Lateral Epicondylitis (NCT04141488)

Eligibility criteria:
Inclusion Criteria:

          -  Cases diagnosed with lateral epicondylitis by the physician and decided to receive
             conservative treatment

          -  Not receiving NSAID or other medical treatment

          -  Untreated Lateral Epicondylitis for the last 6 months

          -  Cases with age range 18-75

          -  Patients with pain and tenderness for at least 3 months

        Exclusion Criteria:

          -  People with pacemakers or cardiac arrhythmias

          -  Tumoral disease

          -  Pregnant women

          -  Head and neck, elbow, scapula joint pathologies

          -  Acute infection

          -  Nerve or nerve root compression

          -  Other musculoskeletal problems
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 68 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Determining the Effectiveness of Sexual Health and Development Education for Children With Intellectual Disability (NCT04635969)

Eligibility criteria:
Inclusion Criteria:

          -  Being between the ages of 12-18

          -  Mild to moderate intellectual disability

          -  Parents agree to participate in research.

          -  Lack of speech and vision impairment

          -  Completing all trainings and follow-ups during the research period

        Exclusion Criteria:

          -  Not being between the ages of 12-18

          -  Having several intellectual disability

          -  Parents not agree to participate in research.

          -  Having speech and vision impairment

          -  Not completing all trainings and follow-ups during the research period
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 12 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Use of Otoscope as a Non-Invasive Tool for Diagnosis of Pilomatricoma (NCT00715819)

Eligibility criteria:
Inclusion Criteria:- Potential participants will be any patient that is seen at Stanford
        Dermatology or LPCH that has a cyst, nodule, vesicle, tumor, or possible pilomatricoma
        Exclusion Criteria:- Inability of subject or subject's guardian to understand informed
        consent form.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Swiss Hemophilia Registry (NCT02512250)

Eligibility criteria:
Inclusion Criteria:

        Diagnosis of hemophilia or other severe bleeding disorders. Signed inform consent

        Exclusion Criteria:

        None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Usability Study of the Focus Touch™ Conception System: Semen Collection (NCT01585012)

Eligibility criteria:
Inclusion Criteria:

          -  Heterosexual, monogamous couples, of any race or ethnicity, who are sexually active

          -  20 - 50 years of age

          -  Signed Informed Consent

          -  Past experience with using condoms

          -  Trying to conceive or using a non-vaginal birth control with which they do not
             normally use a condom.

        Exclusion Criteria:

          -  Vaginal tract medical interventions with the last three (3) month

          -  Vaginal prolapse

          -  Full Hysterectomy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment