araag2/NLI4PR huggingface dataset:
Clinical trial: A Study of Ibandronate [Bonviva/Boniva] and Alendronate in Female Patients With Post-Menopausal Osteoporosis (NCT01128257)

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients, >/= 55 years of age

          -  Postmenopausal osteoporosis

          -  Patients who are in the opinion of the physician eligible to participate in this study

        Exclusion Criteria:

          -  N/A
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Deep Brain Stimulation Effects in Essential Tremor (NCT04581941)

Eligibility criteria:
Inclusion Criteria

          -  Patient gives an informed consent.

          -  Patient is over 21 years of age.

          -  Having a diagnosis of a essential tremor confirmed by a trained movement disorders
             neurologist;

          -  Having failed or not tolerated conventional medical management, at the discretion of
             the neurologist managing the patient;

        Exclusion Criteria

          -  Having alternative diagnoses to essential tremor;

          -  Having comorbid neurodegenerative disorders that may affect mobility or cognition
             (e.g. comorbid Parkinson's disease or dystonia);

          -  Having sequelae of prior brain insult (e.g. prior stroke or brain tumor);

          -  History of prior resective brain surgery (e.g. tumor resection);

          -  Not being a DBS candidate;

          -  Receiving unilateral implants

          -  Having a higher surgical risk that precludes patient from having standard
             intraoperative mapping.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Phase II/III Clinical Study of R484iv (Ibandronic Acid) for Primary Osteoporosis (NCT00447915)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with fragile bone fracture

          -  Patients in whom either of study site analysis value of bone density of lumbar spine,
             proximal part of femur or neck of femur is less than 80% of young adult mean (YAM).

          -  Patients with 1 - 5 bone fractures in 4th thoracic spine (Th4) - 4th lumbar spine (L4)

          -  Ambulatory

        Exclusion Criteria:

          -  Patients with disease lowering bone volume secondarily (secondary osteoporosis)

          -  Patients receiving at least one time of of oral bisphosphonate preparations within 6
             months before the start of administration of the study drug

          -  Patient with disorder delaying the passage of food through esophagus
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Detection of Deterioration by SNAP40 Versus Standard Monitoring in the ED (NCT03179267)

Eligibility criteria:
Inclusion Criteria:

          1. Participant aged 16 years or over AND

          2. Participant triaged to Majors (High Dependency or Immediate Care) OR Participants who
             are stepped down from Resuscitation room care to High Dependency or Immediate Care

        Exclusion Criteria:

          1. Participants under 16 years of age

          2. Previous participation in the study

          3. Participant in custody

          4. Participants deemed high risk for absconding by clinical staff

          5. Participants unable to communicate in English

          6. Participants who are triaged to immediate resuscitation. These participants may be
             considered for inclusion once immediate assessment and treatment have been initiated
             and they are stepped down to High Dependency (HD)/Immediate Care (IC) areas

          7. Patients with implantable defibrillators, pacemakers or neurostimulators will be
             excluded

          8. Patients who cannot have blood pressure measured in both arms e.g. patients with renal
             fistula, a Peripherally Inserted Central Catheter (PICC) line or who have had a lymph
             node clearance
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: A Comparative Study of the Safety and Efficacy of Face Talc Slurry and Iodopovidone for Pleurodesis (NCT00430664)

Eligibility criteria:
Inclusion Criteria:

          -  Age over 12 years

          -  Symptomatic recurrent pleural effusion

          -  Pneumothorax needing pleurodesis

        Exclusion Criteria:

          -  Life expectancy <1 month

          -  Unwilling to give consent

          -  Empyema

          -  ICTD drain output >150 ml/d

          -  Presence of an airleak
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: A Trial Evaluating the Effects of Zoledronic Acid 5 mg Infusion on Bone Mineral Density (BMD) in Postmenopausal Osteoporosis (PMO) Patients Between the Ages of 50 and 65 Years (NCT00909961)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal osteoporosis

          -  Patients who has a low bone mineral density at hip or vertebral

          -  Patients who has an osteoporotic fracture at hip or vertebra

        Exclusion Criteria:

          -  Hypersensitivity either to the active substance or to any of the excipients or to any
             biphosphonates.

          -  Known metabolic bone disease excluding osteoporosis.

          -  Serious systemic disorder treated with drugs interfering with bone metabolism.

          -  Significant liver or renal failure

          -  Pathologic fracture in the examined body area or elsewhere.

          -  Previous anti-osteoporotic treatment within 12 months or less prior to the
             recruitment.

          -  Patients with hypocalcaemia

        Other protocol-defined inclusion/exclusion criteria may apply
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Training of Patients With Dysphagia (NCT04402307)

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with dysphaigia

          -  Patients living in the participating locations

        Exclusion Criteria:

          -  Patients who are linguistically or cognitively unable to participate

          -  Patients who are unable to collaborate about the training

          -  Palliative patients

          -  Patients with a probe
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of Androgen and Growth Hormone on Height and Learning in Girls With Turner Syndrome (NCT00029159)

Eligibility criteria:
-  Karyotype diagnosis compatible with Turner syndrome, but no presence of any Y material
             in the peripheral karyotype unless a gonadectomy has been performed;

          -  Chronological age between 10.0 and 14.9 years;

          -  Bone age less than or equal to 12 years; and

          -  No treatment with estrogen, androgen, growth hormone, or any other growth-promoting
             agents exceeding 12 months, and no treatment with any of these agents in the previous
             3 months.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 14 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Investigation of the Effectiveness of a Structured Squat-based Program in Knee Osteoarthritis Rehabilitation (NCT04588558)

Eligibility criteria:
Inclusion Criteria:

          1. The age range is between 40-65 years old

          2. According to ACR criteria, clinically and radiographically, at least one of the knees
             should be diagnosed with knee OA (within the last 6 months)

          3. Having findings consistent with Kellgren-Lawrence grade II-III OA on knee radiography

          4. Pain between 2-7 according to the visual analog scale

        Exclusion Criteria:

          1. Acute OA in the knee

          2. Comorbid diseases (advanced osteoporosis, vertigo, neurological diseases, etc.),
             injuries and surgeries where exercise is contraindicated

          3. Use of NSAIDs and similar disease modifying drugs (Diacerein, Glucosamine etc.) in the
             last month

          4. Having exercised regularly in the last 6 months (more than 1 day a week)

          5. Having had arthroplasty surgery

          6. Intra-articular injection (hyaluronic acid / steroid) application in the last 6 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Circulating Exosomes As Potential Prognostic And Predictive Biomarkers In Advanced Gastric Cancer Patients ("EXO-PPP Study") (NCT01779583)

Eligibility criteria:
Inclusion Criteria:

        Subjects eligible for enrollment must meet all of the following criteria:

          1. Provide signed informed consent. The subject is capable of understanding and complying
             with parameters as outlined in the protocol and able to sign informed consent,
             approved by the Independent Ethic Committee (IEC)/Institutional Review Board (IRB)
             prior to the initiation of any study-specific procedures

          2. Men or women aged >= 18 years.

          3. Eastern Cooperative Oncology Group Performance Status (ECOG) <= 2.

          4. Histologically confirmed adenocarcinoma of the stomach, gastroesophageal junction or
             esophagus.

          5. Metastatic disease or locally advanced disease not amenable to curative surgery.

          6. Radiographically assessable, non-measurable disease or measurable disease as per
             RECIST criteria.

          7. Life expectancy of at least 12 weeks from the time of enrollment.

          8. No other malignancy within the past 5 years except adequately treated basal cell or
             squamous cell skin cancer or carcinoma in situ of the cervix.

          9. No prior chemotherapy for advanced disease.

        Exclusion Criteria:

        Subjects meeting any of the following criteria must not be enrolled in the study:

          1. Gastric carcinoid, sarcomas, or squamous cell cancer.

          2. Pregnant or lactating females.

          3. Significant neurological or psychiatric disorders (psychotic disorders, dementia or
             seizures) that would prohibit the understanding and giving of informed consent.

          4. Active Hepatitis B or C or history of an HIV infection.

          5. Active uncontrolled infection.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment