araag2/NLI4PR huggingface dataset:
Clinical trial: Patient Functioning and Well-being, Economic, and Clinical Impact of Hemophilia A and Its Treatment (NCT02396862)

Eligibility criteria:
Inclusion Criteria:

          -  Age 16 or over.

          -  Have documentation of physician-confirmed diagnosis of moderate or severe Hemophilia A
             (severity defined as moderate = FVIII activity 1% to 5% and severe = FVIII activity
             ≤1%).

          -  Signed written informed consent provided by the patient or the patient's parents for
             patients under the age of 18 (dependent of local regulations).

          -  Signed written assent is also required for patients under the age 18 years (dependent
             on local regulations).

          -  Plan to receive at least half of their Hemophilia care at the registry site.

          -  Willing and able to enter data as per the data collection schedule.

          -  Currently receiving prophylactic or on demand treatment (including within last 6months
             for on demand).

          -  Expected life expectancy of at least 2 years.

        Exclusion Criteria:

          -  Patients with Hemophilia B

          -  Patients with von Willebrand disease (vWD)

          -  Patients with other rare bleeding disorders

          -  Unable to comply with the study protocol
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Conventional Versus Virtual Reality Based Vestibular Rehabilitation (NCT01442623)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of peripheral vestibular dysfunction and no other neurological
             deficit (confirmed where possible with vestibular function testing; canal paresis
             >20%).

          -  One of the following subjective complaints indicating a failure of vestibular
             compensation; disequilibrium, gait instability, vertigo/dizziness, motion sensitivity.

          -  Not taking medication for vertigo or willing to discontinue with permission from
             consultant physician.

        Exclusion Criteria:

          -  Bilateral peripheral vestibular pathology.

          -  CNS involvement.

          -  Fluctuating Symptoms (Meniere's disease, migrainous vertigo) or active BPPV.

          -  Other medical conditions in the acute phase (orthopaedic injury).

          -  Previous vestibular rehabilitation.

          -  Pacemaker, Epilepsy (as per Nintendo Wii Guidelines).

          -  Unwilling or unable to use a Nintendo Wii.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Contradiction
Clinical trial: Hemoglobin and INR Out of Nose Blood (NCT02370381)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with active nose bleeding

          -  Indication for routine blood sampling

          -  Aged 18 to 99 years

          -  Verbal informed consent before implementation takes place

          -  Written consent of the participating person after investigation and completion of
             treatment

        Exclusion Criteria:

          -  No active bleeding

          -  Routine blood sampling for medical reasons not indicated

          -  Lack of understanding of the study or investigation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Entailment
Clinical trial: E3810-A001-312: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers (NCT00236197)

Eligibility criteria:
Key Inclusion Criteria:

          1. Male or female patients > 18 years of age.

          2. If female, not of childbearing potential by reason of surgery or menopause, or of
             childbearing potential, but using an approved method of contraception since the last
             menstrual period. Females of childbearing potential must have a negative serum
             pregnancy test before starting the study.

          3. Patients must report a history of heartburn at least two days per week over the past
             month.

        Key Exclusion Criteria:

          1. History of erosive esophagitis verified by endoscopy.

          2. History of gastroesophageal reflux disease (GERD) diagnosed by a physician.

          3. Patients who have a history of Barrett's esophagus or esophageal stricture.

          4. Evidence of any medical condition that may interfere with the conduct of the study,
             the interpretation of study results, or the health of the patient during the study.

          5. Patients who require continuous use of proton pump inhibitors, histamine receptor (H2)
             blockers, or prokinetics. Prior intermittent use of these agents is permitted if they
             are discontinued at least three days prior to the run-in phase. The H2 blocker,
             cimetidine (Tagamet®), must be discontinued for at least seven days before the study
             drug is administered.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effect of Low Intensity Ultrasound Therapy on Chronic Pain Due to Osteoarthritis of the Knee. (NCT03679507)

Eligibility criteria:
Inclusion Criteria:

          1. Osteo-arthritis of knee joint diagnosed through X-Ray evaluation

          2. Moderate or sever level of pain due to knee osteoarthritis and no other known reason

          3. Male of Female patients of 18 to 85 years old

          4. Pain interfering with activities of daily life

        Exclusion Criteria:

          1. Cancer pain or any other concurrent cancerous condition

          2. History of Knee replacement surgery in the study joint

          3. Local infection or any kind of inflammatory or allergic skin lesion

          4. Rheumatoid arthritis

          5. Mobility disorders or not being able to walk
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Pressure and Flow Study Before and After Treatments for EMD. The pFlow Study (NCT03904004)

Eligibility criteria:
Inclusion Criteria:

          -  to present with GI symptoms that are secondary to EMD such as dysphagia, regurgitation
             and/or non-cardiac chest pain.

          -  the EMD patients to be recruited under this study are achalasia type I, II and III;
             OGJ outflow obstruction; distal oesophageal spasm, hypercontractile oesophagus or
             disorders not fulfilling Chicago Criteria v3.

          -  Receive a treatment such as POEM, neumatic dilatation, LHM, botox injection.

        Exclusion Criteria:

          -  Exclusion criteria are the inability to fill in symptom questionnaires, intolerance of
             pre or post procedure test, incomplete therapeutic procedures or technical failure of
             baseline manometry investigation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle (NCT00614406)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-35

          -  Normal menstrual periods (24-35 days)

          -  Good general health

          -  Willing to use a non-hormonal form of contraception for the entire study (Acceptable
             forms of contraception include condoms, spermicide, sexual contact with a sterilized
             partner, subject is surgically sterile, same-sex partner, Copper IUD and abstinence)

          -  Willing and able to return to clinic for bi-weekly blood tests

        Exclusion Criteria:

          -  Pregnant or breast feeding

          -  Polycystic ovarian disease

          -  Gastrointestinal conditions (i.e.gastric ulcer)

          -  Currently using birth control

          -  Known allergy to aspirin, non-steroidal anti-inflammatory drugs (NSAIDS) or
             Sulfa-drugs

          -  Diabetes

          -  Cardiac disease or hypertension

          -  Moderate to severe heartburn (GERD)

          -  Obesity (BMI greater than 30)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Lcr35 for Children With Functional Constipation (NCT01985867)

Eligibility criteria:
Inclusion Criteria:

          -  Children below 5 years of age

          -  Functional constipation according to Rome III criteria i.e. 1 month of at least 2 of
             the following:

               -  Two or fewer defecations per week

               -  At least 1 episode per week of incontinence after the acquisition of toileting
                  skills

               -  History of excessive stool retention

               -  History of painful or hard bowel movements

               -  Presence of a large fecal mass in the rectum

               -  History of large- diameter stools that may obstruct the toilet

        Exclusion Criteria:

          -  Irritable bowel syndrome

          -  Mental retardation

          -  Endocrine disease (e.g. hypothyroidism)

          -  Organic cause of constipation (e.g. Hirschsprung disease)

          -  Spinal anomalies

          -  Anatomic defects of the anorectum

          -  History of previous gastrointestinal surgery

          -  Functional nonretentive fecal incontinence

          -  Use of drugs that influence gastrointestinal motility
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 5 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo (NCT01068405)

Eligibility criteria:
Inclusion Criteria:

          -  hand arthritis

          -  pain over 40/100

          -  stable treatment since 4 weeks at least with non-steroid analgesic

          -  between 45 et 85 years

        Exclusion Criteria:

          -  pregnancy or breast feeding women

          -  hyaluronic acid injection within the past 6 months

          -  cortisonic derivated injection within the past 3 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment