araag2/NLI4PR huggingface dataset:
Clinical trial: Continuous Subcutaneous Hydrocortisone Infusion In Addison's Disease and Type 1 Diabetes (NCT01840189)

Eligibility criteria:
Inclusion Criteria:

        - primary Addison's disease in combination with long-standing Type 1 diabetes

        Exclusion Criteria:

          -  cardiovascular disease

          -  active malignant disease

          -  pregnant women

          -  pharmacological treatment with glucocorticoids or drugs that interfere with cortisol
             metabolism (antiepileptics, rifampicin, St. Johns war, estrogens)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: RA-4: 13-cis Retinoic Acid for Treatment of Men With Azoospermia (NCT03323801)

Eligibility criteria:
Inclusion Criteria: Infertile men with azoospermia on at least two semen analyses separated
        by at least one week, and no pregnancy with partner with normal cycles and normal
        hysterosalpingogram despite >1 year of unprotected intercourse.

        -

        Exclusion Criteria: hypogonadotropic hypogonadism (that might respond to gonadotropin
        injections); use of anabolic steroids,illicit drugs, or consumption of more than 4
        alcoholic beverages daily; current therapy with retinoic acid (eg Accutane) or vitamin A-
        of use of isotretinoin within eight weeks of start of dosing;phenytoin, or medication
        containing tetracycline; personal history of serious psychiatric disorders, score of
        greater than 15 on the PHQ9 (mood) questionnaire; elevated serum serum triglycerides or
        other abnormal serum chemistry values; history of inflammatory bowel disease or bone
        disease; not living within catchment area; participation in another clinical trial

        -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Design and Implementation of a Nutritional Intervention in Patients With Oropharyngeal Dysphagia (NCT02959450)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Oropharyngeal Dysphagia.

          -  Patients who have primary caregiver.

          -  Agreeing to participate in the study.

        Exclusion Criteria:

          -  Critically ill patients.

          -  Chronic kidney disease with Glomerular Filtration Rate <30 ml / min or in renal
             replacement therapy

          -  Liver failure.

          -  Cancer with active radiotherapy or chemotherapy treatment.

          -  Patients who are participating in another study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: The Stork OTC: Collection, Placement & Delivery (NCT02038322)

Eligibility criteria:
Inclusion Criteria:

          -  Literacy must be in English (able to understand Informed Consent)

          -  In general good health

          -  Heterosexual, monogamous couples, of any race or ethnicity, who are sexually active
             (as a couple)

          -  18 - 50 years of age

          -  REALM-SF Test Results demonstrate 6th grade literacy or above

          -  Past experience with using condoms

          -  Trying to conceive or using a non-vaginal birth control with which they do not
             normally use a condom.

          -  Signed Informed Consent

        Exclusion Criteria:

          -  Vaginal prolapsed (female)

          -  Hysterectomy (female)

          -  Erectile Dysfunction (male)

          -  Colposcopy with biopsy surgery within the last three (3) months (female)

          -  Treatment for dysplasia surgery within the last three (3) months (female)

          -  Vaginal/cervical surgery within the last three (3) months (female)

          -  Current Pregnancy (female)

          -  Unable to read and understand English
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Platelet Rich Plasma vs Open Surgery in the Treatment of Tennis Elbow (NCT02755727)

Eligibility criteria:
Inclusion Criteria:

        Any patient who:

          -  Has experienced more than 6 months of symptoms from tennis elbow (pain on the lateral
             elbow that radiates down the forearm, point tenderness over the origin of the extensor
             muscles or at its close proximity (within 2.5cm) and pain on resisted extension of the
             Wrist).

          -  Patients must also have failed conservative treatment (a course of physiotherapy and
             activity modification)

          -  Baseline elbow pain >3/10 on VAS during resisted elbow extension.

        Exclusion Criteria:

          -  Presence of a full tendon tear on pre-intervention ultrasound

          -  Unfit for surgical intervention

          -  Have undergone previous elbow surgery,

          -  Have previously undergone PRP injection therapy

          -  Systemic autoimmune rheumatological disease

          -  Receiving immunosuppressive treatments

          -  Received local steroid injection within 3 months of randomization

          -  Unable to comply with follow-up.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Perhexiline Therapy in Patients With Hypertrophic Cardiomyopathy (NCT00500552)

Eligibility criteria:
Inclusion Criteria:

          1. Symptomatic Hypertrophic Cardiomyopathy patients

          2. Abnormal Peak VO2

          3. No significant LVOT obstruction at rest (gradient < 30mmHg)

          4. Sinus rhythm

        Exclusion Criteria:

          1. Abnormal LFT.

          2. Concomitant use of amiodarone

          3. Pre-existing evidence of peripheral neuropathy.

          4. Women of childbearing potential.

          5. Patients with ICD's will be excluded from the MR part of the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: Pilot Study of the Effect of Baclofen and Bromocriptine on Luteinizing Hormone Secretion in Pubertal Children (NCT00004793)

Eligibility criteria:
-  Short stature and/or constitutional growth delay

          -  No epilepsy or risk of epilepsy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: An Efficacy and Safety Study of Fentanyl Transdermal Patch in Filipino Participants With Osteoarthritis and Chronic Low Back Pain (NCT01795898)

Eligibility criteria:
Inclusion Criteria:

          -  Participants diagnosed with osteoarthritis and chronic low back pain

          -  3 months of persistent moderate to severe pain levels

          -  More than 3 times a week frequency or daily moderate to severe pain

          -  Moderate to severe pain at Baseline (at least a score of 4 in the 11-point numerical
             pain scale) Exclusion Criteria

          -  History of allergy to fentanyl transdermal patch or its components and history of
             illicit drug use for the past 3 months

          -  Active skin disease preventing application of the transdermal system

          -  Chronic pulmonary disease (lung disorder)

          -  Participants susceptible to intracranial (inside the skull) effects of carbon dioxide
             retention

          -  Pregnant and breastfeeding mothers
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction
Clinical trial: Healthy Teen Girls: HIV Risk Reduction (NCT00787696)

Eligibility criteria:
Inclusion Criteria:

          -  Female, ages 13 to 17 years, committed to Columbia Training School, who provide
             written informed assent.

        Exclusion Criteria:

          -  Acute or chronic physically illness that would preclude participation as determined by
             facility physician; placement in maximum security unit; study participation during a
             prior commitment
Female
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Genetic Characterization of Dementia (NCT01867359)

Eligibility criteria:
-  INCLUSION CRITERIA:

        Previous diagnosis of Dementia by neurologist, other medical care provider, or researcher
        accompanied by sufficient clinical and/or laboratory evidence

        Clinical confirmation of Dementia by the investigator and his associates either by exam
        and/or review of medical records

        Family member of diagnosed dementia patient

        Healthy controls

        EXCLUSION CRITERIA:

        Individuals with any movement disorder secondary to a specific environmental exposure,
        birth injury, metabolic disorder, or brain infection such as encephalitis.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment