araag2/NLI4PR huggingface dataset:
Clinical trial: Sleep Intervention in Young Boys With Duchenne Muscular Dystrophy (NCT04529707)

Eligibility criteria:
Inclusion Criteria:

          -  Parents/caregivers of youth between ages 6 and 17 with a primary diagnosis of Duchenne
             muscular dystrophy (DMD) who lives at home .

          -  Access to a smart-phone or computer and internet for the weekly web-based sessions, as
             well as uploading of the Actigraph data;

          -  English speaking.

        Exclusion Criteria:

          -  Unable to speak or read English

          -  Their child with DMD has cognitive or behavioral concerns that would limit
             participation and follow-through of intervention;

          -  Their child/youth with DMD is currently receiving an intervention for a sleep related
             disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 18 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Efficacy and Safety of Osilodrostat in Cushing's Syndrome (NCT02468193)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with confirmed Cushing's syndrome [i.e. ectopic corticotropin syndrome,
             adrenal adenoma, adrenal carcinoma, ACTH-Independent Macronodular Adrenal Hyperplasia
             (AIMAH), or Primary Pigmented Nodular Adrenal Dysplasia (PPNAD)]

          -  For patients on medical treatment for hypercortisolism due to Cushing's syndrome, the
             washout periods had to be completed prior to baseline efficacy assessments

        Exclusion Criteria:

          -  Patients with Cushing's disease

          -  History of hypersensitivity to osilodrostat or to drugs of similar chemical classes

          -  History of malignancy of any organ system, treated or untreated, within the past 5
             years

          -  Patients receiving treatment for within 4 weeks or ≤5 x half-life of the agent
             (whichever is longer) before first dose of osilodrostat

          -  Patients with risk factors for QTc prolongation or Torsade de Pointes
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of TAP (Transversus Abdominis Plane) and Ilioinguinal/Iliohypogastric Nerve Block for Analgesia of Open Inguinal Herniorrhaphy (NCT01429480)

Eligibility criteria:
Inclusion Criteria:

          -  Patients undergoing elective primary unilateral open tension-free mesh inguinal hernia
             repair

        Exclusion Criteria:

          -  Inability to consent to the study

          -  BMI more than 40

          -  Skin infection near injection site

          -  Chronic hepatic or renal failure

          -  Peripheral neuropathy

          -  Proven opioid dependency

          -  Coagulopathy

          -  Thrombocytopenia

          -  Dementia

          -  Lack of orientation

          -  Impossibility to understand VAS

          -  Patients suffering from chronic pain
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Regular Physical Exercise in Duchenne Muscular Dystrophy (NCT03963453)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with conclusive DMD diagnosis

          -  Written consent

          -  Able to perform physical exercise and answer questions

        Exclusion Criteria:

          -  Lack of consent

          -  Cognitive disabled unable to answer questionnaire, understand instructions, and able
             to know what they participate in.

          -  Language difficulties
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 18 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Study to Determine the Effect of Food on the Absorption of an Oral Testosterone Undecanoate Formulation (NCT00924612)

Eligibility criteria:
Inclusion Criteria:

          -  Male

          -  Age 18-65

          -  Morning serum testosterone (T) <300 ng/dL on two occasions

        Exclusion Criteria:

          -  Significant intercurrent disease

          -  Abnormal prostate digital rectal exam, elevated PSA, AUA symptom score >15 or history
             of prostate cancer.

          -  Serum transaminases >2 times upper limit of normal

          -  Serum bilirubin >2.0 mg/dL

          -  Hematocrit <35% or >50%

          -  BMI >36

          -  Untreated, obstructive sleep apnea.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: EBUS vs EUS-B for Diagnosing Sarcoidosis (NCT02540694)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical and radiologic suspicion of sarcoidosis stage I (mediastinal or hilar
             lymphadenopathy) or stage II (lymphadenopathy and interparenchymal abnormalities)

          -  Indication for tissue verification of noncaseating granuloma's

          -  Provision of a written informed consent

        Exclusion Criteria:

          -  Life expectancy of less than 6 months

          -  Obvious organ involvement of sarcoidosis with the possibility to confirm granulomas
             with a minimally invasive diagnostic procedure (eg skin lesion or superficial lymph
             node)

          -  Positive acid-fast bacilli sputum test

          -  Contra-indication for endosonography

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy and Safety of Nitazoxanide for Post Exposure Prophylaxis of COVID-19 in Household Contacts (NCT04788407)

Eligibility criteria:
Inclusion Criteria:

          -  Men and women over 18 and under 65.

          -  Household contact with a confirmed case of COVID-19 by PCR for Sars-CoV-2.

          -  Initiate study medication within 4 days from the last close contact with the index
             case.

          -  The patient must not present symptoms suggestive of Covid19 (cough, dyspnea, fever>
             37.5 C, fatigue, sore throat, myalgia, diarrhoea) at the time of admission to the
             study and from previous 14 days.

          -  Informed consent from the patient or legal representative.

        Exclusion Criteria:

          -  History of infection confirmed by SARS-CoV-2.

          -  Positive IgG antibodies test for SARS-CoV-2 at the time of admission.

          -  Have received any dose of nitazoxanide within 7 days prior to screening.

          -  Known hypersensitivity to any of the study medication components.

          -  Use of any investigational or unregistered drug or vaccine within 30 days prior to
             screening, or use planned during the study period.

          -  Inability to comply with study procedures.

          -  Current breastfeeding.

          -  Pregnancy.

          -  Intolerance or inability to take oral medication.

          -  History of severe liver disease (Child-Pugh B or C) and/or chronic kidney disease.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Does Adding Cryostimulation to Conservative Care Help in Managing Chronic Lateral Epicondylitis? a Pilote Study (NCT02308514)

Eligibility criteria:
Inclusion Criteria:

          -  Must have pain at lateral elbow (lateral epicondylitis) for at least six months

          -  Pain must not come from trauma

          -  Painful palpation of the lateral epicondyle

          -  At least one out of two positive test: Cozen's, Mill's

        Exclusion Criteria:

          -  Fibromyalgia

          -  Diabetes

          -  Patient taking more than three medications at the time of inclusion

          -  Cervical radiculopathy

          -  Painful shoulder

          -  Cold intolerance / allergies

          -  Smoking

          -  Cortisone infiltration at the painful lateral epicondyle in the month previous to the
             inclusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Trial of XP (Capecitabine/CDDP) Simvastatin in Advanced Gastric Cancer Patients (NCT01099085)

Eligibility criteria:
Inclusion Criteria:

          1. histologically or cytologically confirmed diagnosis of gastric adenocarcinoma or
             gastroesophageal junction adenoca (i.e. an adenocarcinoma with > 50% extension in the
             stomach)

          2. patients must present with stage IV disease not amenable to surgery, radiation or
             combined modality therapy with curative intent. Patients previously undergoing local
             treatment (surgery and/or radiation) must have subsequently progressed or recurred

          3. measurable or evaluable disease according to RECIST

          4. age, 18 years or older

          5. ECOG performance status 0 - 2

          6. adequate organ function as defined by the following criteria absolute neutrophil count
             (ANC) ≥ 1,500/ul platelets ≥ 100,000/ul AST/ALT ≤ 2.5 x ULN, ≤ 5.0 x ULN if liver
             involvement Total serum bilirubin ≤ 3.0 mg/dL

          7. signed written informed consent

        Exclusion Criteria:

          1. severe co-morbid illness and/or active infections

          2. pregnant or lactating women

          3. active CNS metastases not controllable with radiotherapy or corticosteroids

          4. active and uncontrollable bleeding from gastrointestinal tract

          5. known history of hypersensitivity to study drugs

          6. patients who are already on statin treatment for hyperlipidemia control (if ≥ 1 year
             interval from the last statin dose, the patient is eligible for study entry)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction