Clinical trial: Evaluation of the Efficacy and Safety of Treatments for Patients Hospitalized for COVID-19 Infection Without Signs of Acute Respiratory Failure, in Tunisia (NCT04528927)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed patient COVID19 positive with clinical signs of acute lower respiratory
             infection with signs of pneumonia or bronchitis: fever and / or cough and / or
             difficulty breathing in the absence of acute respiratory failure (PaO2> 60 mmHg) with
             Plus or less :

               -  Chills

               -  Asthenia, fatigability

               -  Headache

               -  Arthromas myalgia

               -  Dry throat

               -  Rhinorrhea

               -  An anosmia

               -  chest pain

               -  Diarrhea

               -  Nausea and vomiting

                    -  Absence of rhythm disturbance (Qt interval <500ms)

                    -  Patients hospitalized in the medical service

                    -  18 years old <Age <80 years old

                    -  Having given written consent for their participation in the study

        Exclusion Criteria:

          -  Allergy to macrolides, local anesthetics such as lidocaine or amide type and
             betalactamines

          -  Take hydroxychloquine in the previous month

          -  Severe / severe liver failure

          -  Kidney failure (GFR <30 ml / min / 1.73 m2)

          -  Ongoing treatments with colchicine, ergot, rye, pimozide, mizolastine, simvastatin,
             lomitapide, alfuzosin, dapoxetine, avanafil, ivabradine, eplerenone, dronedarone,
             quetiapine, ticagrelor, cisapride, astemizole, terfenadine, ranolazine, domperidone.

          -  Complete branch block

          -  Hypovolemia

          -  Retinopathy including vitreous involvement

          -  Psoriasis

          -  Pregnant or breastfeeding woman

          -  hypersensitivity to chloroquine or hydroxychloroquine or to any of the other
             ingredients of this medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction