araag2/NLI4PR huggingface dataset:
Clinical trial: BRAVO Study for Functional Dyspepsia (NCT01349413)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with functional dyspepsia that fulfill Rome III criteria with inadequate
             relief of dyspeptic symptoms

          -  Age >18

          -  Provision of written consent

        Exclusion Criteria:

          -  Presence of organic pathology identified by upper endoscopy or other investigations

          -  Presence of sliding hiatus hernia as defined by flap valve grade IV disruption of
             morphology at gastro-esophageal junction

          -  Concurrent medications that affect gastrointestinal motility

          -  Presence of acid reflux or heartburn symptoms of more than twice a month

          -  History of gastric surgery

          -  H. pylori infection

          -  Use of PPI or NSAID in the past 4 weeks

          -  Pregnancy

          -  Known hypersensitivity to PPI
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Tomographic Findings in COVID-19 and Influenza H1N1 (NCT04499378)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with signed informed consent.

          -  Patients with a positive PCR test for SARS-CoV-2 or influenza H1N1 test upon emergency
             department admission.

          -  Patients with lung CT within 24hrs of specimen collection for PCR test.

          -  Patients with complete 30-day follow-up information.

        Exclusion Criteria:

          -  Patients who are unwilling to undergo a lung CT.

          -  Negative PCR test for SARS-CoV-2 or influenza H1N1 test upon emergency department
             admission.

          -  Patients with a tumor or tumor metastasis on the pulmonary CT.

          -  Patients with a previous or de novo autoimmune disease diagnosis.

          -  Patients with a previous or de novo interstitial lung disease.

          -  Pregnancy.

        Elimination Criteria:

          -  Patients with loss of information on the variables of interest.

          -  Patients without 30-day follow-up information.

          -  Patients who chose to withdraw their participation at any time of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Japanese Upper GI Symptoms Compared With Iranian and Canadian Patients Presenting (NCT03868267)

Eligibility criteria:
Inclusion Criteria:

          -  adult patients (≥18 years of age) who are undergoing esophago-gastro duodenoscopy
             (EGD) for any reason and are consenting to be enrolled in the study during the study
             period.

        Exclusion Criteria:

          -  the patients who cannot speak English in Canada, who cannot speak Japanese in Japan,
             and cannot speak Persian in Iran.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Inspiratory Muscle Training in Individuals With Cystic Fibrosis (NCT03737630)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of cystic fibrosis, confirmed by the sweat test;

          -  14 - 25 years;

          -  Clinical stability;

          -  Absence of bacterial colonization for 4 weeks;

          -  Both sexes;

        Exclusion Criteria:

          -  Inability to perform the protocol established by the study;

          -  Present any intercurrence during data collection;

          -  Being unable to understand and / or perform procedures.

          -  Colonization during study participation;

          -  Patient hospitalization due to worsening of the clinical picture.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.
Subject must be at most 25 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Survey Study of the Treatment and Outcome Management in Patients Diagnosed With Alzheimer's Disease (NCT00291421)

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with new or previous mild or moderate Alzheimer's disease diagnosed
             by a doctor according to medically-accepted definitions

          -  Patients living in ordinary households (for example in their own home or in the home
             of a family member or friend, not in nursing homes or other long-term care facilities)

        Exclusion Criteria:

          -  Patients who are currently participating in another clinical trial
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: The Value of PET-CT in Pleural Effusions (NCT03272997)

Eligibility criteria:
Inclusion Criteria:

          -  Thoracocentesis

          -  Chest X-ray

          -  CT scanning

          -  PET-CT scanning

        Exclusion Criteria:

          -  Missing data

          -  Lung cancer

          -  Thoracic malignancies
No condition on gender to be admitted to the trial.

Subject must be at least 16 Years old.


Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Entailment
Clinical trial: Hormonal Effects on the Uterus and Endometrium (NCT00001454)

Eligibility criteria:
-  INCLUSION CRITERIA:

        Healthy volunteers will be in excellent health.

        Only women with regular menstrual cycles (every 26-35 days) using mechanical (condoms,
        diaphragm) or sterilization methods of contraception will be included.

        Only women with a negative pregnancy test, normal physical examination and laboratory
        results, and a luteal phase progesterone value of greater than 4 ng/mL will be entered into
        this study.

        Women with endometriosis will be recruited from those with histologically-proven
        endometriosis. Except for this diagnosis they will meet criteria for healthy volunteers as
        stated above.

        Women may participate in the study on more than one occasion, but biopsies may not be
        performed in a "baseline" cycle.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 43 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Clinical Intramuscular Gene Transfer Trial of rAAVrh74.MCK.Micro-Dystrophin to Patients With Duchenne Muscular Dystrophy (NCT02376816)

Eligibility criteria:
Inclusion Criteria:

          -  Age 7 or older; must be wheelchair-dependent

          -  Confirmed Dystrophin mutations based on mutation compatibility with micro-dys cDNA
             based on previously published methods.

          -  Males of any ethnic group will be eligible.

          -  Ability to cooperate with muscle testing.

          -  Willingness of sexually active subjects with reproductive capacity to practice
             reliable method of contraception (If appropriate).

        Exclusion Criteria:

          -  Active viral infection based on clinical observations.

          -  Symptoms or signs of cardiomyopathy, including:

               -  Dyspnea on exertion, pedal edema, shortness of breath upon lying flat, or rales
                  at the base of the lungs

               -  Echocardiogram with ejection fraction below 40%

          -  Serological evidence of HIV infection, or Hepatitis A, B or C infection

          -  Diagnosis of (or ongoing treatment for) an autoimmune disease

          -  Concomitant illness or requirement for chronic drug treatment that in the opinion of
             the PI creates unnecessary risks for gene transfer.

          -  Subjects with AAVrh74 binding antibody titers ≥ 1:50 as determined by ELISA
             immunoassay.

          -  Abnormal laboratory values in the clinically significant range as defined in protocol
             or based upon normal values in the Nationwide Children's Hospital Laboratory.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Effectiveness of Nanoone Woman Underwear Using in the Management of Dysmenorrhea (NCT01449305)

Eligibility criteria:
Inclusion Criteria:

          1. Females aged below 40 years old.

          2. Screened by inquiry and diagnosed as primary dysmenorrhea by gynaecologist with pelvic
             ultrasonography.

          3. Female subject who is:

               -  using adequate contraception since last menstruation and no plan for conception
                  during the study.

               -  non-lactating.

               -  has negative pregnancy test (urine) within 14 days prior to the study.

          4. Informed consent form signed.

        Exclusion Criteria:

          1. Sensitivity to study product.

          2. Patient has been diagnosed with secondary dysmenorrhea (defined as identifiable pelvic
             pathology).

          3. Patient has clinically significant physical disability or abnormal findings on
             physical examination or laboratory testing judged by the investigator or
             co-investigator.

          4. Participation of any clinical investigation during the last 30 days.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Measurement of Gait Spatio-Temporal Characteristics in Knee Osteoarthritis Patients (NCT00599729)

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic knee OA for at least 6 months

          -  Fulfilled American College of Rheumatology clinical criteria for OA of the knee

          -  Radiographically assessed OA of the knee graded 1-4 according to the Kellgren &
             Lawrence scale

        Exclusion Criteria:

          -  Acute septic arthritis

          -  Patients with an increased tendency to fall

          -  Lack of physical or mental ability to perform or comply with the treatment procedure

          -  Diabetes mellitus

          -  History of pathological osteoporotic fracture
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment