araag2/NLI4PR huggingface dataset:
Clinical trial: Phase 2B Extension Study of Ataluren (PTC124) in Duchenne/Becker Muscular Dystrophy (DMD/BMD) (NCT00847379)

Eligibility criteria:
Inclusion Criteria:

          -  Completion of blinded study drug treatment in the previous Phase 2b study
             (PTC124-GD-007-DMD).

          -  Ability to provide written informed consent (parental/guardian consent if
             applicable)/assent (if less than [<]18 years of age).

          -  In participants who are sexually active, willingness to abstain from sexual
             intercourse or employ a barrier or medical method of contraception during PTC124
             administration and the 6-week follow up period.

          -  Willingness and ability to comply with scheduled visits, drug administration plan,
             study procedures, laboratory tests, and study restrictions.

        Exclusion Criteria:

          -  Known hypersensitivity to any of the ingredients or excipients of the study drug
             (Litesse® UltraTM [refined polydextrose], polyethylene glycol 3350, Lutrol® micro F127
             [poloxamer 407], mannitol 25C, crospovidone XL10, hydroxyethyl cellulose, vanilla,
             Cab-O-Sil® M5P [colloidal silica], magnesium stearate).

          -  Ongoing participation in any other therapeutic clinical trial.

          -  Prior or ongoing medical condition (for example, concomitant illness, psychiatric
             condition, behavioral disorder, alcoholism, drug abuse), medical history, physical
             findings, ECG findings, or laboratory abnormality that, in the investigator's opinion,
             could adversely affect the safety of the subject, makes it unlikely that the course of
             treatment or follow up would be completed, or could impair the assessment of study
             results.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Residual Gastric Volume After the Ingestion of a Beverage Containing Carbohydrates Plus Whey Protein (NCT01828645)

Eligibility criteria:
Inclusion Criteria:

        patients scheduled to upper digestive endoscopy for diagnostic purposes due to complaints
        of epigastric burning.

        Exclusion Criteria:

        American Society of Anesthesiologists (ASA) score above II, diabetes mellitus, pregnancy,
        renal or hepatic failure, gastroesophageal reflux, acute cholecystitis, use of
        corticosteroids up to 6 months previously, use of any prokynetic drug up to 6 weeks, and
        any noncompliance or violation on the assigned protocol of preoperative fasting.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Phase II Dose-Ranging Study of OrthoDerm Patch for Patients With Tennis Elbow (NCT00447928)

Eligibility criteria:
Inclusion Criteria:

          -  males >18 yr and < 70 yr

          -  BMI < 38

          -  chronic lateral epicondylitis (symptomatic > 3 mo)

          -  pain on provocation >/- 4 on 11 point scale

        Exclusion Criteria:

          -  patients on other pain medications

          -  bilateral elbow pain

          -  any humerus elbow or forearm fracture or surgery

          -  signs of injury other than lateral epicondylitis

          -  any concomitant disease or pain of the upper extremity

          -  orthostatic hypotension

          -  patients taking MAO inhibitors, phosphodiesterase inhibitors, adrenergic agents

          -  pregnant or nursing women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: HMB- Data Collection Methods (NCT02001324)

Eligibility criteria:
Inclusion Criteria:

        Patients who are presenting for gynecologic visits or well-woman examinations who still
        have an intact uterus and are between the ages of 18 and 51 years, have abnormal uterine
        bleeding, and can read and write in English.

        Exclusion Criteria:

          -  Women who are presently on a treatment for abnormal uterine bleeding.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 51 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) (NCT01822106)

Eligibility criteria:
Inclusion Criteria:

          1. Gender:Male or female.

          2. Age: from 20 y/o to 75 y/o.

          3. The diagnosis is Gastroesophageal Reflux Disease.

          4. With the symptoms of heartburn or acid regurgitation.

          5. After explaining thoroughly the whole research purpose or process, the clients are
             willing to sign the agreement.

        Exclusion Criteria:

          1. Exclude peptic ulcer, gall bladder stone (including intraheptaic and common hepatical
             duct) and major diseased of cancer.

          2. Barrett's esophagus or esophagus stricture.

          3. The operation history of esophagus or gastroduodenoal regions.

          4. Tarry stool suspected GI tract bleeding.

          5. With the history of alcohol or drug abuse.

          6. The clients with the history of study drug allergy.

          7. The clients with psychologic cannot cooperate with each other.

          8. The pregnant woman or the lactating women.

          9. Abnormal liver function such as GOT, GPT elevated over double the normal range.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Study on Ultrapro vs Polypropylene: Early Results From a Multicentric Experience in Surgery for Hernia (NCT02666040)

Eligibility criteria:
Inclusion Criteria:

          -  Elective surgery

          -  Males and females

          -  Adults over 18

          -  All primitive inguinal hernia

        Exclusion Criteria:

          -  Emergency surgery

          -  Impossibility to complete the follow-up

          -  Patients with acquired immunodeficiency symptoms

          -  Patients with relapsed inguinal hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Assessment of Iron Deposition in Major Organs of Hemodialysis Patients (NCT01169961)

Eligibility criteria:
Inclusion Criteria:

          -  patients for study are > 50 years of age,

          -  on chronic hemodialysis for at least one year,

          -  with serum ferritin levels > 2000 ng/ml and TSAT > 30%.

        Exclusion Criteria:

          -  malignancies,

          -  any active infection requiring systemic antibiotic therapy, and

          -  hospitalization within the two weeks before screening.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Continuous Measurement of the Activity for Clinical Evaluation at Home, for Non-ambulant Neuromuscular Patients (NCT01611597)

Eligibility criteria:
Inclusion Criteria:

          -  age over 10 years

          -  neuromuscular disease documented by genetic testing or by muscle biopsy

          -  not able to walk 10 meters without support

          -  capable of sitting upright in a wheelchair for at least 3 hours

          -  subject affiliated to a social security system

          -  subject who signed an informed consent

        Exclusion Criteria:

          -  severe intellectual impairment limiting the comprehension of the demanded tasks

          -  acute neurologic, inflammatory, infectious, endocrine, orthopedic disease in the month
             preceding the inclusion

          -  surgery scheduled within 3 weeks after enrollment

          -  surgery at upper limbs in the three months preceding the inclusion

          -  pregnant or nursing women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 80 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparation of Endoscopic Biopsy and Postoperative Specimen for the Molecular Diagnosis of Gastric Cancer (NCT04809025)

Eligibility criteria:
Inclusion Criteria:

          1. Lower age limit of research subjects 18 years old and upper age limit of 75 years old.

          2. Histologically proven primary gastric adenocarcinoma (Diagnostic biopsies must be
             collected within 12 months prior to enrollment).

          3. Written informed consent from the patient.

          4. Patients planned for radical R0 gastrectomy.

        Exclusion Criteria:

          1. Female in pregnancy or lactation.

          2. Patients with gastric cancer who can not undergo tumor resection

          3. Suffering from other serious diseases, including cardiovascular, respiratory, kidney,
             or liver disease, complicated by poorly controlled hypertension, diabetes, mental
             disorders or diseases.

          4. Patients with poor compliance or considered to be poor compliance.

          5. Patients received any anticancer drugs, biotherapy, radiotherapy or immunotherapy
             within 4 weeks before or after enrollment.

          6. Patients after organ transplantation, long-term need to take immunosuppressants,
             autoimmune diseases.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Differences in Coagulation Test Kits (NCT01109667)

Eligibility criteria:
Inclusion Criteria:

        Routine control patients receiving and not receiving oral anticoagulant therapy

        Exclusion Criteria:

        Hemolytic and/or lipemic samples were excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Entailment