araag2/NLI4PR huggingface dataset:
Clinical trial: TGA (Thrombin Generation Assay) and Prophylaxis in Haemophilia (NCT02781766)

Eligibility criteria:
Inclusion Criteria:

          -  Severe haemophilia A (FVIII < 1 IU/dl)

          -  Currently on prophylactic therapy

          -  The same prophylaxis regimen in the last six months

          -  Age: 2 (with a body weight ≥12.5 kg ) - 45 years

          -  Adequate venous access

          -  Haemophilia patient's diary or equivalent regularly completed

          -  Ability of patient or family (for minors) to give informed consent

          -  Subject with health insurance

        Exclusion Criteria:

          -  Age <2 and >45 years

          -  Haemophilia A with documented inhibitor in the last 12 months

          -  Clinically symptomatic liver disease (historical evidence documented in patient's
             medical file)

          -  Platelet count < 100x109/l

          -  Poor venous access

          -  Presence of a documented target joint

          -  Subject under legal protection measure.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of α MAT Versus Steroid Injection in Knee Osteoarthritis (STα MAT-knee Study) (NCT04230902)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who are ≥ 45 years old

          -  Symptomatic knee OA defined as symptoms of knee pain and/or decreased range of motion
             (ROM)

          -  Classified radiographically as having Grade 2 or 3 Knee OA

          -  Failure of 3-months conservative management (NSAIDs and Physical therapy)

        Exclusion Criteria:

          -  Patients < 45 years old

          -  Pregnant or breastfeeding women

          -  Cancer patients

          -  Rheumatoid arthritis patients

          -  Patients having any autoimmune disease affecting the joint

          -  Patients who have had hyaluronic acid injection <1 year ago

          -  Patients who have undergone lower extremity surgery or trauma on the same side

          -  Hypersensitivity to methylprednisolone (Depo-Medrol®)or any of its components,
             lidocaine/xylocaine or any of its components, and any of the ingredients of Lipogems®
             injection kit

          -  Patients with acute systemic or local infection

          -  Patients on anticoagulants (warfarin, coumadin, heparin, Xeralto, or Plavix)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Thoracic Ultrasound in the Treatment of Pleural Effusion (NCT02505763)

Eligibility criteria:
Inclusion Criteria:

          -  Patients hospitalized or seen in consultation with pleural effusion diagnosed
             clinically or radiologically whatever be its initial management.

        Exclusion Criteria:

          -  Patient with a neoplasia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Contradiction
Clinical trial: Rhythmical Massage Compared With Heart Rate Variability Biofeedback in Women With Menstrual Pain (Dysmenorrhea) (NCT03712800)

Eligibility criteria:
Inclusion Criteria:

          -  At least one year of primary dysmenorrhea (physician-confirmed).

          -  Written informed consent (also from parents/legal guardians of underage girls).

          -  Menarche at least one year ago.

        Exclusion Criteria:

          -  Secondary dysmenorrhea.

          -  Participation in another study.

          -  Mental retardation.

          -  Addiction.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 46 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Constitution of a Clinical, Neurophysiological and Biological Cohort for Chronic Sleep Disorders Responsible of Hypersomnolence (NCT03998020)

Eligibility criteria:
Inclusion Criteria:

          -  following a diagnostic of chronic sleep disorders responsible to hypersomnolence with
             a score at the Epworth scale better than 10/24

          -  can be treated or not for chronic sleep disorder.

          -  speak and understand french

          -  should have a social security system

          -  should not have infectious or inflammatory pathology

        Exclusion Criteria:

          -  be private of liberty

          -  live in medical institution

          -  be a major protected by law

          -  not have social security system

          -  refuse to participate in protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.


Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? Entailment
Clinical trial: IL-11 in Women With Von Willebrand Disease and Refractory Menorrhagia (NCT00524342)

Eligibility criteria:
Inclusion Criteria:

          -  Females 18-45 years of age

          -  Confirmed type 1 VWD, as defined by low VWF:RCoF or low VWF:Ag and qualitatively
             normal VWF multimers

          -  Menorrhagia refractory to estrogens, hormones, hemostatic agents

          -  Willingness to have blood drawn

        Exclusion Criteria:

          -  Use of immunomodulatory or experimental drugs, or diuretics

          -  Pregnant or lactating women or those unwilling to use contraception during study

          -  Previous cardiac disease, congestive failure, arrhythmia (e.g., atrial fibrillation,
             atrial flutter), hypertension, MI, stroke, or thrombosis

          -  Past allergic reaction to Neumega or DDAVP

          -  Surgery within the past 8 weeks

          -  Inability to comply with study protocol requirements

          -  Concomitant use of antiplatelet drugs, anticoagulants, dextran, aspirin or NSAIDs

          -  Treatment with DDAVP, cryoprecipitate, whole blood, plasma and plasma derivatives
             containing substantial quantities of FVIII and/or VWF within five days of study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Cooperative Parent Mediated Therapy in Children With Fragile X Syndrome and Williams Syndrome (NCT04610424)

Eligibility criteria:
Inclusion Criteria:

          -  Molecularly confirmed diagnosis of Fragile X Syndrome

          -  Molecularly confirmed diagnosis of Williams-Beuren Syndrome

          -  Autism features

          -  Score > or = 4 in Clinical Global Impression (Guy et al., 1976)

        Exclusion Criteria:

          -  Parent yet enrolled in a parent training during first evaluation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 7 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Short-Term Androgen Priming Before COS Using Aromatase Inhibitor and hCG During Early-Follicular-Phase GnRH Antagonist Administration - a Randomized Controlled Trial (NCT00286364)

Eligibility criteria:
Inclusion Criteria:

          -  Indication and wish for IVF/ICSI treatment

          -  Womens age 20-39 years (both inclusive)

          -  Regular menstrual cycle within normal range

          -  Body Mass Index: 18-30 kg/m2 (both inclusive)

          -  Negative pregnancy test before treatment

          -  A maximum of 3 earlier IVF/ICSI treatments that did not result in pregnancy

        Exclusion Criteria:

          -  serious systemic disease

          -  Presence of polycystic ovarian syndrome (PCOS)

          -  Earlier poor response with less than 4 mature follicles

          -  Earlier participation in the investigation
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy and Safety Study of XP12B in Women With Menorrhagia (NCT00386308)

Eligibility criteria:
Inclusion Criteria:

          -  Women with menorrhagia

          -  18-49 years of age

          -  Regularly occurring menstrual periods

        Exclusion Criteria:

          -  History or presence of clinically significant disease or abnormalities that may
             confound the study

          -  History of bilateral oophorectomy or hysterectomy

          -  Hormone therapy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 49 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: PDE Inhibitors in DMD Study (Acute Dosing Study) (NCT01580501)

Eligibility criteria:
Inclusion Criteria:

          1. diagnosis of DMD confirmed by muscle biopsy or DNA analysis

          2. age 7-15y

          3. ambulatory

          4. no clinical evidence of heart failure

        Exclusion Criteria:

          1. hypertension, diabetes, or heart failure by standard clinical criteria

          2. elevated BNP level (>100 pg/ml)

          3. LVEF < 50%

          4. non-ambulatory

          5. cardiac rhythm disorder, specifically: rhythm other than sinus, SVT, atrial
             fibrillation, ventricular tachycardia

          6. continuous ventilatory support

          7. liver disease

          8. renal impairment

          9. contraindications to sildenafil (use of nitrates, alpha-blockers, CYP3A inhibitors,
             amlodipine, or other PDE5A inhibitors)
Male
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 15 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment