araag2/NLI4PR huggingface dataset:
Clinical trial: Evaluation of IVA (SE Femur Scans) to Identify Incomplete AFFs (NCT01747304)

Eligibility criteria:
Inclusion Criteria:

        Known AFF group

          1. A subject must have experienced an incomplete atypical low trauma fracture of the
             femoral shaft;

          2. Is a patient at the UHN osteoporosis clinic.

        Comparison Group

          1. Must be scheduled for a bone mineral density scan at UHN

          2. Have been on any bisphosphonate for 5 years or longer, and;

          3. Have unexplained symptoms of leg, hip, thigh, or knee pain.

        Exclusion Criteria:

          -  There are no exclusions
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Vaginal Hysterectomy Versus Laparoscopically Assisted Vaginal Hysterectomy for Large Uteri (NCT02826304)

Eligibility criteria:
Inclusion Criteria:

          1. Age between 40 and 70 years.

          2. Uterine weight more than 280gm. the weight will be estimated sonographically using
             algebraic formula by Kung and Chang expressed in weights and measurements: weight(g)=
             50+(4/3 x π(Pi) x L/2 x W/2 x AP/2) where (L) is the length of the uterus from the
             dome of the fundus to the level of the external os and (W) is the maximum width of the
             uterus at the level of the cornua and (AP) is the anteroposterior diameter of the
             uterus . Both (W) and (AP) will be taken perpendicular to the axis of the uterine
             length.

          3. Presence of a benign cause for hysterectomy. e.g: fibroid uterus, simple endometrial
             hyperplasia not responding to medical treatment and adenomyosis.

        Exclusion Criteria:

          1. Patients medically unfit for laparoscopy as severely compromised cardiac patients.

          2. Obese patients (BMI>30).

          3. Presence of endometriosis.

          4. Previous myomectomy

          5. Presence of adnexal mass

          6. Known or suspected gynecological malignancy.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Mirvaso® Gel and Dysport® for Erythema and Flushing of Rosacea (NCT03508869)

Eligibility criteria:
Inclusion Criteria:

          1. Male or female

          2. 18 years of age or older

          3. Clinical diagnosis of rosacea

          4. Moderate to severe persistent facial erythema associated with rosacea at baseline, as
             determined by: a grade of greater than or equal to 3 on the 5 point grading scale1
             (Figure 1)

          5. No known medical conditions that may interfere with study participation

          6. Willingness to not use any products on their face for the duration of the study

          7. Read, understand, and sign informed consent forms

          8. Willingness to sign photography release form

          9. Willing and able to comply with all follow-up requirements

         10. Willingness to undergo treatment using Mirvaso® Gel and Dysport®

        Exclusion Criteria:

          1. Any significant skin disease at treatment area

          2. Any medical condition which could interfere with the treatment

          3. Inability or unwillingness to follow the treatment schedule

          4. Inability or unwillingness to sign the informed consent

          5. Pregnant or lactating

          6. Allergy to cow's milk protein

          7. Previous or current use of Mirvaso® Gel

          8. Known hypersensitivity to Dysport® , Mirvaso® Gel or any of their ingredients

          9. Previous Dysport® treatment 6 months prior to the screening visit
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Risk of Diabetes in Young Turner Syndrome Patients (NCT02160717)

Eligibility criteria:
Turner Syndrome Females:

        Inclusion Criteria:

          -  Turner Syndrome confirmed by chromosomal testing

          -  On standard therapy (growth hormone and or estrogen)

        Exclusion Criteria:

          -  Type 1 or Type 2 diabetes

          -  Polycystic Ovarian Syndrome

          -  Pregnancy

          -  On any medications that alter blood sugar

        Healthy Female Controls:

        Inclusion Criteria:

          -  Healthy

        Exclusion Criteria:

          -  Type 1 or Type 2 diabetes

          -  Polycystic Ovarian Syndrome

          -  Pregnancy

          -  On any medications that alter blood sugar
Female
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 22 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Iron Absorption Trial (NCT02228902)

Eligibility criteria:
Inclusion Criteria:

          -  patients who are eligible for a primary Roux- en -Y gastric bypass and who have no
             pre-existing iron deficiency (serum ferritin between 20-200 micrograms/L)

        Exclusion Criteria:

          -  blood transfusion one month before ans in the study period. The use of iron containing
             nutritional supplements, except our standardized multivitamin supplements. Decreased
             function of the kidney with a GFR of < 30ml/min and a serum creatinin below 50
             micromol/L. Hb< 7.4 mmol/L in females en Hb< 8.4 mmol/L in males. Accumulation of
             iron. Hypersensitivity for ons of the medicinal products. Psychiatric illness.
             Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: An Innovative Mind-motor Exercise Approach to Osteoarthritis Treatment (NCT02753634)

Eligibility criteria:
Inclusion Criteria:

          -  Knee osteoarthritis

        Exclusion Criteria:

          -  WOMAC less than 4

          -  Use of braces

          -  Uncontrolled hypertension

          -  Significant psychiatric or psychotic disorder

          -  Not able to attend 75% of sessions

          -  Any other reason that would prevent participation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Cardioneuroablation for Reflex Syncope (NCT03903744)

Eligibility criteria:
Inclusion Criteria:

          -  At least one documented spontaneous VVS during preceding 12 months or one syncope in
             history leading to injury and minimum 2 presyncopal events during preceding 12 months,
             refractory to all recommended types of standard treatment.

          -  In case of lack of ECG documentation during spontaneous syncope and history suggesting
             reflex syncope, at least 3 seconds of asystole due to sinus arrest or
             atrio-ventricular block with syncope or bradycardia <40 beats per minute with syncope
             or presyncope during baseline tilt test

          -  Sinus rhythm during ECG and tilt test

          -  Significantly decreased quality of life due to syncope

          -  Positive response to atropine test

          -  Obtained written informed consent.

        Exclusion Criteria:

          -  Other possible and treatable causes of syncope such as significant cardiac disease,
             cardiac arrhythmia or abnormalities of vertebro-basiliar arteries

          -  History of stroke or TIA

          -  History of cardiac surgery

          -  Contraindications to ablation in the right or left atrium
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of Relapse, Efficacy and Safety of Long-term Treatment With Oracea® vs Placebo (NCT01426269)

Eligibility criteria:
Inclusion Criteria:

          -  Subject is male or female aged 18 to 80 years inclusive.

          -  Subject with papulopustular rosacea (11 to 40 papules or pustules) and an IGA of
             moderate or severe.

          -  For subjects using medications to treat a concurrent medical condition, type and dose
             must have been stable for at least 90 days prior to study entry.

        Exclusion Criteria:

          -  Female subjects who are pregnant, nursing or planning a pregnancy during the study.

          -  Subject has any other active dermatological condition on the face that may interfere
             with the conduct of the study.

          -  Subject uses or has recently used any medication which may interfere with the
             absorption, distribution, or elimination of study medications, or may interfere with
             the assessments of efficacy or safety of the study medications.

          -  Subject has a known allergy to any of the components of the study products, and/or a
             known hypersensitivity to tetracyclines or metronidazole.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Tablet-based Cognitive Training (NCT04452864)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Alzheimer's Disease

          -  Patients with increased risk for developing dementia

          -  Must be able to give their consent

        Exclusion Criteria:

          -  Contra-indications for MRI scanning

          -  Substance abuse

          -  Severe medical conditions
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: School Intervention With Daily Physical Activity and Healthy Food for Students With an Intellectual Disability. (NCT01291238)

Eligibility criteria:
Inclusion Criteria:

          -  mild/moderate intellectual disability

          -  students at the upper secondary schools for intellectual disability students

        Exclusion Criteria:

          -  severe intellectual disability

          -  obesity related syndromes

          -  major physical disabilities
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 22 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment