araag2/NLI4PR huggingface dataset:
Clinical trial: Rational Approach to a Unilateral Pleural Effusion (NCT03272087)

Eligibility criteria:
Inclusion Criteria:

          1. Patients with recurrent pleural effusion of unknown origin after a first pleural tap
             according to BTS guidelines.

          2. Indication for thoracoscopy according to BTS guidelines.

          3. Patients accept further investigation according to Danish and BTS guidelines.

          4. Have received oral and written consent and agreed.

          5. At the time of inclusion, above 18 years of age.

        Exclusion Criteria:

          1. Female patients: pregnancy or breastfeeding.

          2. Lack of language comprehension.

          3. Legally incompetent patients.

          4. Life expectancy less than 3 month.

          5. Contraindications to pleural tissue sampling.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Contradiction
Clinical trial: Mesenchymal Stem Cells Enhanced With PRP Versus PRP In OA Knee (NCT01985633)

Eligibility criteria:
Inclusion Criteria:

          1. Grade 1 or Grade 2 Osteoarthritis knee as per Ahlbacks radiographic staging

          2. Patients willing to give consent

        Exclusion Criteria:

          1. Osteoarthritis secondary to joint inflammatory diseases (eg- rheumatoid arthritis,
             ankylosing spondylitis etc)

          2. Patients with other diseases, affecting the knee joint like crystal arthropathy,
             symptomatic chondrocalcinosis, acute synovitis, excessive joint effusion(>100ml),
             cystic disease around the knee joint(eg-popliteal cyst)

          3. Advanced stage of osteoarthritis

          4. Bone marrow suppression

          5. Co morbidities like pregnancy, cancer, immunosuppression,

          6. Osteoarthritis secondary to trauma
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Intra-venous Zoledronic Acid Once Yearly (NCT00984893)

Eligibility criteria:
Inclusion Criteria:

          -  Patient is an ambulatory female 45 years of age or older

          -  Postmenopausal women with diagnosis of osteoporosis

          -  Prescription of zoledronic acid or any OBP as per the current Canadian monograph

          -  Must provide informed consent

        Exclusion Criteria:

          -  Any prior use of iv bisphosphonates within the last 2 years

          -  Known secondary osteoporosis of any aetiology (hypogonadism in premenopausal women or
             premature menopause, malabsorption, chronic liver disease, inflammatory bowel disease)

          -  Metabolic bone diseases such as primary or secondary hyperparathyroidism,
             hypoparathyroidism, Paget's disease of bone, Fibrous dysplasia..

          -  Non-corrected hypocalcaemia at the time of zoledronic acid infusion

          -  Creatinine clearance < or = 30 ml/min

          -  Unwillingness or inability to comply with the study requirements

          -  Concurrent participation in a clinical trial of an investigational drug, or within the
             last 30 days

        Other protocol-defined inclusion/exclusion criteria may apply.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Gas Supply, Demand and Middle Ear Gas Balance -- Fly/Dive Simulation (NCT01976429)

Eligibility criteria:
Inclusion Criteria:

          -  bilaterally intact tympanic membranes

          -  flyer or diver with middle-ear symptoms

          -  flyer or diver without middle-ear symptoms (controls)

          -  generally good health

          -  no recent history of non-activity related otitis media

        Exclusion Criteria:

          -  existing middle-ear disease

          -  allergic rhinitis symptoms or "cold" on day of testing

          -  syndrome predisposing to otitis media

          -  history of ossicular reconstruction
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction
Clinical trial: AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion (NCT04322136)

Eligibility criteria:
Inclusion Criteria:

          1. Patients with a symptomatic MPE*

          2. Predicted survival of more than 6 months

          3. Eastern Cooperative Oncology Group (ECOG) score = Peformance status defined as a
             patient's level of functioning in terms of their ability to care for themselves, daily
             activity, and physical ability (walking, working, etc. ECOG 0-1 (or ECOG greater than
             or equal to 2 if it is felt that removal of pleural fluid would improve their status
             to 0 or 1).

               -  MPE is defined as histologically/cytologically proven pleural malignancy or an
                  otherwise unexplained pleural effusion in the context of clinically proven cancer
                  elsewhere.

        Exclusion Criteria:

          1. Age <18yrs;

          2. Unfit to undergo a surgical procedure (American Society of Anaesthesiologists Score
             >/=4); 3. Pleural infection;

        4. Chylothorax; 5. Pregnancy or lactation; 6. Uncorrectable bleeding diathesis; 7. Previous
        ipsilateral lobectomy/pneumonectomy; 8. Inability to consent or comply with protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Therapy in Amyotrophic Lateral Sclerosis (TAME) (NCT02118727)

Eligibility criteria:
Inclusion Criteria:

          1. Age 18-85

          2. Male or Female

          3. Clinically definite, probable, probable lab-supported, or possible ALS by El Escorial
             criteria

          4. ALSFRS-R > 25

          5. Must be willing to undergo longitudinal blood draws for biomarker analysis

          6. Must have a caregiver

          7. Availability and willingness to complete the study

          8. Capable of providing informed consent and complying with trial procedures

          9. If patients are taking riluzole and/or Radicava, they must be a on a stable dose for
             at least thirty days prior to the baseline.

        Exclusion Criteria:

          1. Patients with FVC ≤ 60%

          2. History of liver disease

          3. Severe renal failure

          4. History of intolerance to memantine

          5. Onset of weakness for greater than 3 years

          6. Any other co-morbid condition which would make completion of the trial unlikely

          7. If female, pregnant or breast-feeding; or, if of childbearing age, an unwillingness to
             use birth control.

          8. Taking any trial medications. Non-trial medications are not cause for exclusion.

          9. Unwillingness to provide consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Spinal Manipulation and Spinal Mobilization Effects in Participants With and Without Back Pain (NCT02660801)

Eligibility criteria:
Inclusion Criteria:

          -  presenting or not a history of chronic nonspecific back pain

        Exclusion Criteria:

          -  History of back trauma or surgery

          -  Severe osteoarthritis

          -  Inflammatory arthritis

          -  Vascular conditions

          -  Contraindication to the use of spinal manipulation or spinal mobilization

          -  Pregnancy

          -  Scoliosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Prospective Evaluation of Symptom Resolution in Acid Versus Non-acid Reflux Disease Following Anti-reflux Surgery (NCT01241149)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who are offered anti-reflux surgical treatment with elevated DeMeester scores
             or with low (less than 14.7) DeMeester scores, but with positive impedance scores
             (positive symptom index associated with reflux episodes).

        Exclusion Criteria:

          -  • Previous major upper gastrointestinal surgery (includes esophagus, stomach, and
             duodenum) - previous cholecystectomy (gallbladder removal) is not considered a major
             upper GI surgery

               -  Presence of paraesophageal hernia (type II - type IV)

               -  Presence of large hiatal hernia >5cm

               -  Presence of peptic strictures

               -  History of severe esophageal motility disorders such as:

                    -  achalasia

                    -  diffuse esophageal spasms

                    -  scleroderma

                    -  poorly-controlled diabetes mellitus

                    -  autonomic or peripheral neuropathy

                    -  myopathy

               -  Pregnancy (As a standard operating procedure, women of child-bearing age will
                  undergo a urine pregnancy test the morning of surgery because anti-reflux surgery
                  is considered an elective case, where pregnancy is a relative contraindication.)

               -  BMI greater than 40

               -  Undergoes Collis gastroplasty during surgery

               -  Conversion to an open procedure

               -  Age less than 18 years old
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 17 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: A Survey Collecting Data on Adult Height in Patients With Achondroplasia Treated With Somatropin (NCT01435629)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who were enrolled in the GH-1941 study (1997 to 2006) and expected to
             theoretically reach the adult height within the study period
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction