araag2/NLI4PR huggingface dataset:
Clinical trial: A Study to Determine Safety & Efficacy of Autologous Human Platelet Lysate in Lateral Epicondylitis (Tennis Elbow) (NCT01668862)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with clinical diagnosis of tennis elbow within the last 3 months

          -  Subjects both male and female, aged 18-60 years (both inclusive)

          -  Subjects who are willing to give informed consent and adhere to the study protocol

        Exclusion Criteria:

          -  Subjects aged less than 18 and more than 60 years

          -  Subjects with autoimmune diseases

          -  Subjects with immuno-compromised system

          -  Subjects on Anti-coagulant therapy or blood thinning medicines like Aspirin

          -  Subjects taking concomitant therapy that might interfere with the study results in
             investigators opinion or who had concomitant other injury of the tennis elbow tendons.

          -  Subjects who have received treatment with corticosteroid injections within the last 6
             months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: An Open-label Safety and Efficacy Study of Recombinant FVIII in Patients With Severe Hemophilia A (NCT02172950)

Eligibility criteria:
Inclusion Criteria:

        PTPs:

          -  Males of any age who have been diagnosed with severe congenital hemophilia A (FVIII
             activity levels < 1%) and who participated in a previous CSL-sponsored clinical study
             with rVIII-SingleChain.

          -  Males 0 to <65 years age who have been diagnosed with severe congenital hemophilia A
             (FVIII activity levels < 1%), who have at least 50 EDs to any FVIII product, and who
             are not currently enrolled in a CSL-sponsored clinical study with rVIII-SingleChain.

        PUPs:

          -  Males 0 to <18 years of who have been diagnosed with severe congenital hemophilia A
             (FVIII activity levels < 1%)

          -  No prior exposure to any Factor VIII product (with the exception of short-term use of
             blood products).

        ITI substudy:

          -  PUPs who have developed a confirmed inhibitor to rVIII-SingleChain in the main study.

        Exclusion Criteria:

          -  Known or suspected hypersensitivity to rVIII-SingleChain or to any excipients of
             rVIII-SingleChain or Chinese hamster ovary (CHO) proteins.

          -  Currently receiving a therapy not permitted during the study.

          -  Serum creatinine > 2 x upper limit of normal, alanine aminotransferase or aspartate
             aminotransferase > 5 x upper limit of normal at Screening (if specified)

          -  Any first-order family (eg, siblings) history of FVIII inhibitors

          -  For PTPs not rolling over directly from a CSL-sponsored clinical study with
             rVIII-SingleChain: any history of or current FVIII inhibitors
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study Evaluating the Pharmacokinetics of the Potential Drug Interaction Between CYP2C9 Inhibitor and Substrate (NCT00369304)

Eligibility criteria:
1. Men and women, aged 18 to 50 years. Women of non-childbearing potential may be
             included.

          2. Body mass index in the range of 18 to 30 kg/meter squared and body weight equal to or
             greater than 50 kg.

          3. Healthy as determined by the investigator on the basis of medical history, physical
             examination, clinical laboratory test results, vital signs, and 12 lead
             electrocardiogram (graphic trace of the pattern of your heart beat).

          4. Non-smoker or smoker of fewer than 10 cigarettes (half a pack) per day as determined
             by history. Must abstain from smoking during inpatient stay.

          5. Have a high probability for compliance with and completion of the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Alendronate in an Weekly Effervescent Tablet Formulation Following Denosumab Discontinuation (NCT04338529)

Eligibility criteria:
Inclusion Criteria:

        i) osteopenic postmenopausal Caucasian women following Dmab treatment ii) assignment to
        treatment with alendronate in an effervescent tablet formulation following Dmab
        discontinuation

        Exclusion Criteria:

        i) secondary osteoporosis; ii) diseases that could affect bone metabolism iii) medications
        that could affect bone metabolism iv) chronic kidney disease (stage >3b) and/or liver
        failure v) neoplastic disease vi) hypersensitivity to alendronate or to any of the
        excipients vii) abnormalities of the esophagus and other factors which delay esophageal
        emptying such as stricture or achalasia viii) inability to stand or sit upright for at
        least 30 minutes ix) hypocalcaemia x) confirmed esophagitis
Female


Subject must be at most 90 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Validation of the Adenomyosis Calculator (NCT04135118)

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal (defined by having had menstruation the last six month)

          -  If amenorrhea with levonorgestrel intrauterine device, the woman should be < 45 years
             old

          -  Hysterectomy planned due to a benign condition

          -  Hysterectomy does not require morcellation it is allowed to divide the uterus into 2-3
             pieces, given that the orientation of the specimen is still possible for the
             pathologist)

          -  Written consent is given

          -  Can communicate in Norwegian or English at the Norwegian study sites, and Finnish,
             Swedish or English at the Finnish study site.

        Exclusion Criteria:

          -  Gynecological cancer present at the time of inclusion

          -  Use of gonadotropin-releasing hormone agonist or antagonist within the last 3 months
             prior to the ultrasound evaluation

          -  Prior endometrial ablation or resection

          -  Postmenopausal status or no menstrual bleeding for the last 6 months, or amenorrhea
             with levonorgestrel-intrauterine device and age >45 years.

          -  Need for morcellation of the uterus
Female
No healthy subjects accepted to join the trial.

Subject must be at most 52 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: A Comparison Study of Three Standard Elbow Wrist Hand Orthoses to Limit Forearm Rotation (NCT04130425)

Eligibility criteria:
Inclusion Criteria:

          -  No prior wrist or elbow injuries on the dominant side of his/her body

          -  Ability to complete study in one sitting of 90-120 minutes

          -  Between the ages of 18 years and 100 years

          -  Ability to follow directions and speak and read English

        Exclusion Criteria:

          -  Prior wrist or elbow injuries on the dominant side of his/her body

          -  Subjects with known rheumatoid arthritis deformities of the wrist or any prior wrist
             surgeries are excluded
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Understanding Pain Perception in Osteoarthritis (NCT02603939)

Eligibility criteria:
Inclusion criteria:

        Inclusion Criteria for OA patients:

        Study participant will be recruited from rheumatology outpatient clinics and primary care:

          1. fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of
             knee osteoarthritis

          2. male or female,

          3. symptomatic knee pain

          4. on usual care for knee osteoarthritis including paracetamol and/or non-steroidal
             anti-inflammatory drugs

          5. participants between 35 and 90 who will be undergoing knee replacement surgery or
             arthroscopy for osteoarthritis or knee surgery for fractured tibia/femur/fibula with
             osteoarthritis

        Inclusion criteria for Early OA Patients

        Study participant will be recruited from rheumatology outpatient clinics and primary care:

          1. fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of
             knee osteoarthritis

          2. male or female,

          3. symptomatic knee pain

          4. on usual care for knee osteoarthritis including paracetamol and/or non-steroidal
             anti-inflammatory drugs

          5. Participants between 35 and 90 who have osteoarthritis but will not be undergoing knee
             surgery

        Inclusion criteria for Healthy control subjects

        1. Participants aged between 35 and 90 who do not have knee pain or osteoarthritis as a
        comparator group
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Senofilcon A Lenses in Moderate to Severe Dry Eye Disease (NCT04096898)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of moderate to severe dry eye associated with either
             Graft-versus-host disease (GVHD), Sjogren syndrome, idiopathic dry eyes, or minimal
             limbal cell deficiency

          -  A baseline Schirmer tear test (1) of less than 5 mm at 5 minutes without anesthesia

          -  Have a visual analog score for comfort of 50 or less (scale of 1-100, with 100 meaning
             perfect ocular comfort and 1 meaning severe ocular pain)

          -  Ability or the resources to insert and remove the study lenses

          -  An OSDI score greater than 42

          -  A willingness to sign an informed consent

        Exclusion Criteria:

          -  No dry eyes or mild dry eyes

          -  A baseline Schirmer tear test (1) of greater than 5 mm of wetting at 5 minutes

          -  Dry eye comfort score of greater than 50 on a visual analog scale

          -  Unable to insert or remove the study lenses (or have a family member do so)

          -  Have an OSDI score less than 42

          -  Has been diagnosed with neurotrophic keratopathy in either eye

          -  Unwilling to enroll in the study, and unwilling to provide signed informed consent to
             participate in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: New Patient Support Program in Type 2 Diabetes (NCT03752567)

Eligibility criteria:
Criteria Inclusion:

          -  age> 18 years,

          -  patients with type 2 diabetes mellitus diagnosis;

          -  able to express consent to the study.

        Exclusion Criteria:

        - Nobody
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment