araag2/NLI4PR huggingface dataset:
Clinical trial: Evaluating the Effects of Traditional Chinese Medicine by N-of-1 Trials (NCT03147443)

Eligibility criteria:
Inclusion Criteria:

          -  the diagnostic criteria based on the consensus of Chinese experts and the guidelines
             for noncystic fibrosis bronchiectasis issued by the British Thoracic Society in 2010;

          -  male or female, aged 18-70 years;

          -  being in the stable stage, and no acute exacerbation of bronchiectasis within the past
             three weeks;

          -  frequency of acute exacerbation of bronchiectasis ≤ 3 times every year;

          -  signed informed consent for participation.

        Exclusion Criteria:

          -  having developed respiratory failure with estimated survival time less than one year;

          -  having hemoptysis as a comorbidity;

          -  having complications by active tuberculosis;

          -  being pregnant or with severe heart, liver,and kidney dysfunctions;

          -  participating in other pharmacological clinical trials within the past 3 months.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Interest in Spirituality and Oncology: Is It An International Phenomenon? (NCT00429117)

Eligibility criteria:
Inclusion Criteria:

          -  Physician members of the International Gynecologic Oncologists Society or the Society
             of Gynecologic Oncologists

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? Entailment
Clinical trial: Detachable String Magnetically Controlled Capsule Endoscopy for Completely Viewing of Esophagus and Stomach (NCT03457909)

Eligibility criteria:
Inclusion Criteria:

          -  outpatients who have esophagus symptoms.

        Exclusion Criteria:

          -  known or suspected complex history of gastrointestinal obstruction, stenosis or
             fistula.

          -  dysphagia or delayed gastric emptying.

          -  known or suspected possibility of active bleeding of digestive tract.

          -  a history of abdominal operation.

          -  pacemaker implantation and gastrointestinal pacemaker users.

          -  patients who are allergic to simethicone or pronase.

          -  pregnant women,mental patients.

          -  other circumstances that doctors consider inappropriate for the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of Early Endocapsule (EC) in Clinical Decision Unit Versus Standard of Care Work-up for GI Bleeding (NCT03955055)

Eligibility criteria:
Inclusion Criteria:

          -  Age greater than 18 years old

          -  New onset of hematemesis, melena or hematochezia

          -  Able to sign consent

          -  Hemodynamically stable (that is, blood pressure >100/60 or pulse <110 at the time of
             consent)

          -  Emergency Department must plan to admit patient to the hospital or Clinical Decision
             Unit

          -  If patients have pacemakers and/or implantable cardioverter defibrillator (ICD), they
             will be placed on telemetry

        Exclusion Criteria:

          -  adults unable to consent

          -  individuals who are not yet adults (infants, children, teenagers)

          -  pregnant women

          -  prisoners

          -  prior history of gastroparesis

          -  prior history of gastric or small bowel surgery

          -  prior history of inflammatory bowel disease

          -  concern for infectious colitis

          -  evidence of dysphagia at the time of presentation

          -  presence of small amounts of bright red blood per rectum

          -  allergy to metoclopramide or erythromycin

          -  code status of do not resuscitate/do not intubate (DNR/DNI) or comfort measures only
             (CMO)

          -  prior history of abdominal radiation

          -  abdominal pain suggesting an acute abdomen or obstruction.

          -  patients who cannot undergo surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Vital Sign Comparison Between Lifelight and Standard of Care - Development (NCT04003662)

Eligibility criteria:
Inclusion Criteria:

          -  I1. Sufficiently conversant in the English language to satisfy I3.

          -  I2. Able and willing to comply with all study requirements.

          -  I3. Able and willing to provide written informed consent to participate (including by
             parent or legal guardian if under 16 years old).

        Exclusion Criteria:

          -  There are no exclusion criteria.
No condition on gender to be admitted to the trial.

Subject must be at least 3 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients (NCT01768468)

Eligibility criteria:
Inclusion Criteria:

          -  Patients ≥40 and ≤ 80years of age

          -  Radiographic evidence of grade 2 or 3 osteoarthritis based on the Kellgren & Lawrene
             radiographic entry criteria

          -  Stable osteoarthritis during 3 months

          -  Score of 100mm pain VAS ≤ 80mm at screening

          -  Score of 100mm pain VAS ≥ 50mm at baseline

          -  Written consent form voluntarily

        Exclusion Criteria:

          -  Disease of spine or other Lower limb joints that could affect to evaluate the efficacy

          -  History of surgery or arthroscopy of the study joint within 6 months

          -  Trauma of study joint within 12 months

          -  Medication of constantly(more than 1 week) corticosteroid by oral within 3 months

          -  Medication of intra-articular injection within 3 months

          -  Diagnosed with psychical disorder, and taking medication

          -  History of upper gastrointestinal ulceration within 6 months

          -  History of upper gastrointestinal bleeding within 12 months

          -  Serum creatinine, ALT, AST, total bilirubin over UNL X 2.0 at screening test

          -  History of hypersensitivity to LAYLA, JOINS, or NSAIDs

          -  Participation in another clinical trials within 4 weeks

          -  Medication of constantly (more than 1 week) narcotic analgesics within 3 months

          -  Not consent about using effectual contraception method during trial

          -  Pregnant or lactating woman

          -  Investigator's judgment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Management of Pain in Oral Lichen Planus (NCT03572959)

Eligibility criteria:
Inclusion Criteria:

          -  histological diagnosis of OLP on the basis of WHO criteria (Meji and van der Waal
             2003).

          -  presence of painful and atrophic-erosive oral lesions, unresponsive to topical
             corticosteroid therapy

          -  ability to complete the present clinical trial.

        Exclusion Criteria:

          -  Presence of histological signs of dysplasia

          -  use of lichenoid reaction inducing drugs

          -  Therapy for OLP in the 2 months prior to the study;

          -  Patients suffering from any disease that may present with features similar to OLP
             (graft versus host disease or lupus erythematosus)

          -  Pregnant or lactating females

          -  Patients with uncontrolled diabetes or hypertension, positive HCV Ab or HBs Ag.

          -  Smokers
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 62 Years

Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions (NCT03899298)

Eligibility criteria:
Inclusion Criteria:

          1. Age 18 and over.

          2. Ability to attend follow up visits or at least converse on phone or complete email
             follow up forms.

          3. Competent to understand the study protocol and provide voluntary informed consent.

          4. Patients with any of the following conditions: Arthritis (Degenerative, Rheumatoid,
             Psoriatic, Lupus, Gout), Sports or Overuse Injuries (e.g. Rotator Cuff injury, Tennis
             Elbow), Chronic Kidney Disease (may be on dialysis), Back/Neck Pain, Erectile
             Dysfunction, Peyronie's Disease, Alzheimer's Disease, Parkinson's Disease, Neuropathy,
             Post-Stroke, Post-Concussion Syndrome, COPD, Emphysema, Pulmonary Fibrosis, Post
             myocardial infarction (at least 6 months out), Cardiomyopathy, Congestive Heart
             Failure.

        Exclusion Criteria:

          1. Active Cancer

          2. Pregnancy, Lactating

          3. Severe Clotting disorder

          4. Myocardial Infarction less than six months ago.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of Proprioseptive Vestibular Rehabilitation in Patients With Peripheral Vestibular Hypofunction (NCT04687371)

Eligibility criteria:
Inclusion Criteria:

          -  Between 18-65 years

          -  Diagnosis of vertigo according to the clinical examination performed by an
             Otorhinolaryngologist, Vestibular Evoked Myogenic Potentials (VEMP), Video Head
             Impulse Test (VHIT)

          -  Patients with Unilateral Peripheral Hypofunction

          -  After giving detailed information about the research, agreeing to participate in the
             study.

        Exclusion Criteria:

          -  Severe hearing / vision impairment-loss

          -  Patients with neurological, orthopedic, circulatory system problems that may cause
             vertigo, dizziness and balance disorders

          -  Having severe hypertension / diabetes

          -  Previous participation in a vestibular rehabilitation program

          -  Being healthy

          -  Patients using drugs that may affect the treatment negatively

          -  Refusing to participate in a clinical trial

          -  Patients who cannot adapt to the training program

          -  Patients who discontinued their treatment

          -  Patients with different diagnoses that may disrupt the treatment during the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment