Clinical trial: Effect of Cis-9-cetylmyristoleate in Sub-healthy Subjects Presenting With Knee Joint Pain (NCT02800759)

Eligibility criteria:
Inclusion Criteria:

          -  sub-healthy persons >18 years of age and knee joint pain with a 0-10 numerical rating
             scale (NRS) pain score ≤ 4.

        Exclusion Criteria:

          -  current medication use related to arthritis;

          -  current use of FAC containing products;

          -  clinical or radiological diagnosis as moderate degree arthritis accompanied by
             peri-articular spur formation, irregular joint margin, and/or subchondral cyst;

          -  previous history of knee surgery;

          -  pregnant, breastfeeding, or practicing contraception with reliable methods, or not
             accepting our guidelines during the research periods;

          -  major pain other than knee joint pain;

          -  current treatment of gastritis or gastric ulcer;

          -  abnormal screening laboratory results;

          -  major cardiac, renal disease, or disability that could affect adverse effect
             assessment or interfere with study completion when enrolled;

          -  history of major procedures or operations that might affect study results;

          -  enrollment in another clinical trial or human application testing; and

          -  judged as unsuitable for human application testing.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction