araag2/NLI4PR huggingface dataset:
Clinical trial: Cyriax Manipulation in Lumbar Derangement Syndrome (NCT04082065)

Eligibility criteria:
Inclusion Criteria:

          -  lumber pain, pain radiating to leg, motor deficits in legs, , dural signs and
             symptoms, impaired nerve root mobility(straight leg raise and L3 stretch), back pain
             effecting Quality of life, ODI score less than 30 and Limited range of motion .

        Exclusion Criteria:

          -  Osteoporosis of hip, Bilateral sciatica, having anticoagulant medication, pregnancy,
             patient with impaired mental status
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient description (patient's own words): I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Does the patient match the trial criteria? Contradiction
Clinical trial: Correlation Analysis of Hearing Thresholds, Validated Questionnaires and Psychoacoustic Measurements in Tinnitus Patients (NCT00976547)

Eligibility criteria:
Inclusion Criteria:

          -  tinnitus for more than 6 months

          -  sensorineural hearing loss

          -  normal otoscopy

        Exclusion Criteria:

          -  conductive or mixed hearing losses

          -  A-r, A-d, B and C tympanograms

          -  tinnitus treatment in the last 6 months

          -  pregnant woman

          -  Vestibular Schwannoma
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy and Safety Study of XP12B in Women With Menorrhagia (NCT00386308)

Eligibility criteria:
Inclusion Criteria:

          -  Women with menorrhagia

          -  18-49 years of age

          -  Regularly occurring menstrual periods

        Exclusion Criteria:

          -  History or presence of clinically significant disease or abnormalities that may
             confound the study

          -  History of bilateral oophorectomy or hysterectomy

          -  Hormone therapy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 49 Years

Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Contradiction
Clinical trial: Knee Pain Nurse Led Package of CareTrial (NCT03670706)

Eligibility criteria:
Inclusion Criteria:

          -  Knee pain on most days of the previous month

          -  At least moderate pain on two of the five WOMAC knee pain domains in the most painful
             knee

          -  Knee pain present for longer than 3 months

        Exclusion Criteria:• House-bound or care home resident

          -  Dementia

          -  Dialysis

          -  On home oxygen

          -  Serious mental illness

          -  Inability to communicate in English

          -  Unable to give consent

          -  Terminal cancer

          -  Known diagnosis of autoimmune rheumatic diseases or psoriasis

          -  Knee or hip replacement, or on waiting list for knee or hip replacement

          -  Asthma or COPD requiring regular daily oral corticosteroids

          -  Unstable angina or heart failure

          -  Known peripheral vascular disease

          -  Pregnant
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Safety and Efficacy of IQP-LH-101 in Postprandial Heartburn (NCT01718639)

Eligibility criteria:
Inclusion Criteria:

          -  Post-prandial heartburn (e.g. after a high-fat meal) in at least 2 months prior to the
             study (at least 2 times a week)

          -  Not receiving prescribed treatment for heartburn, reflux or upper gastrointestinal
             disorders

          -  Written informed consent is a prerequisite for subject enrollment.

        Exclusion Criteria:

          -  Gastrointestinal bleeding within 12 months prior to the study

          -  Difficulty swallowing (dysphagia)

          -  History of or symptoms suggestive of Zollinger-Ellison syndrome, oesophageal or
             gastric malignancy, gastric or duodenal ulcer, pernicious anaemia, Barrett's
             oesophagus or systemic sclerosis

          -  Participation in other studies within the last 30 days prior to entry or during the
             study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Issues Surrounding Prenatal Genetic Testing for Achondroplasia (NCT00001536)

Eligibility criteria:
Adult individuals of either gender with achondroplasia and their first degree relatives
        (both short and average statured) of all ethnic and cultural backgrounds.

        No short-statured persons with conditions other than achondroplasia.

        No average-statured family members of short statured persons with conditions other than
        achondroplasia.

        No minors less than 18 years of age.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome (NCT00233363)

Eligibility criteria:
Inclusion Criteria:

          1. Patients with Sjögren's syndrome (Revised Japanese criteria for Sjögren's syndrome
             (1999): 1998 research report on immunological intractable diseases specified by the
             Japanese Ministry of Health and Welfare)

          2. Patients aged 20 years or older at time of consent

          3. Patients with dry mouth

          4. Patients with decreased salivation

        Exclusion Criteria:

          1. Patients who have developed dry mouth clearly due to a cause other than Sjögren's
             syndrome

          2. Patients in whom Saxon test cannot be performed (artificial tooth, tooth implant,
             etc.)

          3. Patients who have received rebamipide within 3 months prior to obtaining informed
             consent

          4. Patients who are pregnant, possibly pregnant, or lactating

          5. Patients with a history of hypersensitivity to rebamipide

          6. Patients who have received any other investigational drug within 3 months prior to
             obtaining informed consent

          7. Patients who are otherwise judged inappropriate for inclusion in the study by the
             investigator or subinvestigator
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluation of Furosap in Human Volunteers (NCT02748005)

Eligibility criteria:
Inclusion Criteria:

          1. Agrees to written as well as audio-visual informed consent.

          2. Ability to understand the risks/benefits of the protocol

          3. Male between 35-65 years of age.

          4. Diagnosed with Symptomatic hypogonadism

        Exclusion Criteria:

          1. Uncooperative Subjects

          2. Impaired hepatic function indicated by SGOT/SGPT >2.5 times the upper limit of normal.

          3. Abnormal liver or kidney function tests (ALT or AST > 2 times the upper limit of
             normal

          4. elevated creatinine, males > 125 µmol/L or 1.4mg/dl, females > 110 µmol/L or1.2mg/dl)

          5. Patients suffering from CAD

          6. History of malignancy

          7. History of hypersensitivity to any of the investigational drugs Receiving any other
             testosterone booster therapy/medication/supplement within the last 2 months

          8. History of coagulopathies

          9. High alcohol intake (>2 standard drinks per day)

         10. History of psychiatric disorder that may impair the ability of subjects to provide
             written informed consent.

         11. Any medical condition, where the investigator feels participation in the study could
             be detrimental to the subjects overall well-being
Male
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy/Safety of Lansoprazole in Patients With Frequent Heartburn (NCT00390390)

Eligibility criteria:
Inclusion Criteria:

          1. Experiencing heartburn at least 2 days per week over the past month.

          2. Having heartburn that responds to heartburn medication.

          3. Be willing to discontinue the use of heartburn treatment for 7 days prior to inclusion
             in the study.

        Exclusion Criteria:

          1. Having history of erosive esophagitis or gastroesophageal reflux disease diagnosed by
             a physician and confirmed by testing (endoscopy).

          2. Be unwilling to take only the study medication, and antacid provided as a rescue
             medication for relief of acute heartburn during the study.

        Other protocol-defined inclusion or exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Sexual Absorption of Vaginal Progesterone (NCT01959464)

Eligibility criteria:
Inclusion Criteria:

          -  Sexually active 18-40 year old heterosexual couple

          -  Subject willing to take Mircette birth control pills for at least one cycle (one pack)

          -  Willing to have intercourse at the defined times (at least weekly within a 3 week
             interval, and draw blood within 10 hours of intercourse)

          -  IRB signed informed consent

        Exclusion Criteria:

          -  Undiagnosed vaginal bleeding

          -  Contraindication to oral contraceptives

          -  Liver dysfunction or disease

          -  Known sensitivity to Crinone

          -  Known or suspected malignancy of the breast or genital organs

          -  History of or active thrombophlebitis or thromboembolic disorders

          -  Use of condoms during intercourse

          -  Male erectile or ejaculatory dysfunction
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment