araag2/NLI4PR huggingface dataset:
Clinical trial: Study of In-line Pressure Using Various Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase (INFUSE-AT1A) (NCT01116102)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female, aged 18 to 60 years, inclusive.

          -  Body mass index 19.0 to 35.0 kg/m2

          -  Intact normal skin without potentially obscuring tattoos, pigmentation, or lesions on
             the upper back in the area intended for infusion

          -  Free from any clinically significant abnormality on the basis of medical/medication
             history or physical examination

          -  Vital signs and clinical laboratory parameters within normal range or, if outside
             normal range, deemed not clinically significant

          -  Negative urine drug and alcohol screens.

        Exclusion Criteria:

          -  Upper back pathology that could interfere with study outcome.

          -  History of congestive heart failure, known coronary heart disease, active or recent
             pulmonary disease, or renal insufficiency.

          -  Rales on lung auscultation.

          -  Known allergy to hyaluronidase or any other ingredient in the formulation of hylenex
             recombinant

          -  Treatment with furosemide, benzodiazepines, or phenytoin.

          -  Pregnancy or breastfeeding.

          -  Exposure to any experimental drug within 30 days prior to study admission, or previous
             participation in this study.

          -  Any other reason which, in the investigator's opinion, would prevent the safe
             participation in the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study of Disposable Transnasal Esophagoscope (NCT01360515)

Eligibility criteria:
Inclusion Criteria:

          1. aged 20 years or older

          2. endoscopy indicated for reflux symptoms (heartburn, epigastric soreness and/or
             regurgitation), dyspepsia (epigastric discomfort, bloating, early satiety), or
             non-cardiogenic chest pain, or known or suspected to have esophageal varices,
             infectious esophagitis, or other esophageal disease based on their medical history

          3. a written informed consent form

        Exclusion Criteria:

          1. history or symptoms of severe rhinitis and sinusitis

          2. symptoms of acute respiratory inflammation at the time of examination

          3. abnormal anatomy of the nasal cavity or nasopharynx due to nasal tumors or previous
             nasopharyngeal surgery

          4. taking anticoagulants such as coumadin

          5. patients for whom a EGD could not be performed
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Basivertebral Nerve Block During Vertebral Augmentation: An Alternative Approach to Intraprocedural Pain Management (NCT04774029)

Eligibility criteria:
Inclusion Criteria:

          -  Age >50 years old

          -  Patient must have a diagnosis of osteoporosis on dual energy x-ray absorptiometry
             (DEXA),

          -  Patient must have an acute or subacute single level vertebral compression fracture
             between T10 - L3 as confirmed via magnetic resonance imaging (MRI) or nuclear medicine
             bone scan,

          -  Patient must have an initial pain score of greater than or equal to five using a
             standard 0-10 Visual Analog Scale subjective pain score upon initial consultation.

        Exclusion Criteria:

          -  Pathologic compression fracture, such as due to metastatic disease

          -  Age >90 years old or <50 years old

          -  Pregnancy

          -  Diagnosed Anxiety Disorder

          -  Diagnosed Depression Disorder

          -  Diagnosed Psychotic Disorder

          -  Diagnosed Mental Disease Disorder

          -  Diagnosed Parkinson's disease/other movement disorders/or cerebellar dysfunction

          -  Eastern Cooperative Oncology Group (ECOG) score at baseline prior to compression
             fracture >1

          -  Back Pain scores at time of initial consult <5, using a standard Visual Analog Scale

          -  Illicit drug dependence or abuse

          -  Alcohol dependence or abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Cabergoline on Endometrial Vascularity During IntraCytoplasmic Sperm Injection (NCT02306564)

Eligibility criteria:
Inclusion Criteria:

          1. Age ≥18 - ≤40 years

          2. Normal serum prolactin level.

          3. Tubal factor of infertility.

          4. Unexplained infertility.

          5. BMI ≥ 30 kg/m2.

          6. Estradiol (E2)>3,500 pg/ml on day of ovulation trigger.

          7. Patients who underwent coasting for OHSS prevention.

          8. More than 20 follicles ≥11 mm on the day of final oocyte maturation.

        Exclusion criteria:

          1. Contraindication of pregnancy e.g.: Somatic and mental diseases, which are
             contraindications for carrying of a pregnancy and childbirth, inborn malformations or
             acquired deformations of uterus cavity which make embryo implantation or carrying of a
             pregnancy impossible ,ovarian tumors.

          2. Severe Male factor infertility.

          3. Hyperprolactinemic patients.

          4. Frozen embryo transfer cycles

          5. Uterine Anomalies.

          6. Uterine synechia.

          7. History of Genital Tuberculosis.

          8. Repeated implantation failure in ICSI.

          9. On medication that is known to alter prolactin levels e.g antipsychotics, Atypical
             agents and risperidone

         10. Thyroid dysfunction.

         11. Medical disorders affecting serum prolactin eg acromegaly ,chronic renal failure and
             hypothyroidism
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Characteristics and Outcomes of Hospitalized Patients With COVID-19 in Spain (NCT04355871)

Eligibility criteria:
Inclusion Criteria:

          -  Laboratory-confirmed COVID-19 infection by real-time polymerase chain reaction
             (RT-PCR) assay

          -  Hospital admission

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.




Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Detailed Pain Pattern After Laparoscopic Inguinal Hernia Repair (NCT01105039)

Eligibility criteria:
Inclusion Criteria:

          -  men

          -  18-69 years

          -  uni- or bilateral hernia

          -  ASA I-II

          -  Danish speaking

        Exclusion Criteria:

          -  bad compliance

          -  acute operation

          -  daily intake of opioids
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 69 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Exercise Study Including Patients With Hypertrophic Cardiomyopathy (NCT01165749)

Eligibility criteria:
Inclusion Criteria:

          1. Ages 18 - 80 years old.

          2. Diagnosis of hypertrophic cardiomyopathy, defined by the presence of unexplained
             left-ventricular hypertrophy (wall thickening) > 13 mm in any wall segment.

          3. Exercise £ 30 minutes, 1 day per week for the previous 3 months.

          4. Agreement to be a participant in the study protocol and willing/able to return for
             follow-up.

        Exclusion Criteria:

          1. History of exercise-induced syncope or arrhythmias (ventricular tachycardia or
             non-sustained ventricular tachycardia).

          2. Medically refractory LV outflow tract obstruction being evaluated for septal reduction
             therapy.

          3. Less than 3 months post septal reduction therapy (surgery or catheter based
             intervention).

          4. Hypotensive response to exercise (> 20 mmHg drop in systolic blood pressure from peak
             blood pressure to post exercise blood pressure).

          5. Pregnancy.

          6. ICD placement in last 3 months or scheduled.

          7. Life expectancy less than 12 months.

          8. Inability to exercise due to orthopedic or other non-cardiovascular limitations.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of 3 Doses of ARD-0403 in Testosterone Deficient Men (NCT00597051)

Eligibility criteria:
Inclusion Criteria:

          -  Testosterone deficiency

          -  Normal BMI

        Exclusion Criteria:

          -  Previous treatment with testosterone replacement therapy within 4 weeks

          -  Moderate-severe benign prostatic hypertrophy, or prostatic cancer

          -  Haematocrit >50%
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Ultradian Subcutaneous Hydrocortisone Infusion in Addison Disease and Congenital Adrenal Hyperplasia (NCT02096510)

Eligibility criteria:
Inclusion Criteria:

          1. clinical diagnosis of primary adrenal insufficiency

          2. Written informed consent

        Exclusion Criteria:.

          1. Diabetes mellitus

          2. Severe cardiovascular disease

          3. Active malignant disease

          4. Pregnancy or breast feeding

          5. treatment with interfering drugs

          6. Intake of grapefruit juice
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study of Efficacy and Safety of "On-demand" Maintenance Therapy With Rabeprazole in Patients With Non-erosive Reflux Disease (NERD) (NCT00236392)

Eligibility criteria:
Inclusion Criteria:

          -  Minimum of 12 months history of heartburn as the predominant symptom with at least 2
             symptomatic episodes

          -  Negative endoscopy (no erosive lesions according to the Modified Savary-Miller scale)
             within 7 days prior to acute treatment

          -  at least 3 days with moderate to very severe heartburn within one week prior to acute
             treatment

        Exclusion Criteria:

          -  No known gastro-duodenal ulcer

          -  no infections, inflammations, or obstruction of the small or large intestine

          -  no history of gastrointestinal cancer, or prior surgery of the stomach or intestine

          -  no stomach or abdominal pain or discomfort as the predominant symptom or that requires
             treatment

          -  no history of erosive reflux causing inflammation of the esophagus

          -  no stricture of the esophagus, stomach, or any condition that causes difficulty in
             swallowing

          -  no history of non-erosive reflux disease (NERD) that is or was refractory to an
             adequate treatment course (1 month) with proton pump inhibitors

          -  no females who are pregnant or those lacking adequate contraception
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction