araag2/NLI4PR huggingface dataset:
Clinical trial: Heart Rate Variability During the Menstrual Cycle (NCT04382001)

Eligibility criteria:
Inclusion Criteria:

          -  Aged 18 years of age and over

          -  Regular menstrual cycles (23-35 days in length)-

        Exclusion Criteria:

          -  Taking any hormonal medications

          -  Taking any medications that may affect heart rate

          -  Known heart condition or use of a pacemaker

          -  Skin condition where there is sensitivity to wearing a skin monitor

          -  Currently suffering with anxiety or panic attacks

          -  Pregnant or breastfeeding

          -  Undertaking any frequent travel or long-haul flights during the course of the study

          -  Does not have access to an Apple iPhone or iPad with Bluetooth 4.0 (or later) and iOS
             10.0 (or later)
Female

Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect Of Pulsed Electromagnetic Field And Progressive Resistance Exercise On Knee Osteoarthritis (NCT04106986)

Eligibility criteria:
Inclusion Criteria:

          -  40 year-old and above

          -  Diagnosed with unilateral or bilateral knee OA

        Exclusion Criteria:

          -  Patients with current or previous knee surgeries

          -  Inflammatory arthritis's (rheumatoid arthritis, gout, etc.)

          -  Alzheimer disease

          -  Parkinson disease

          -  Unable to walk unaided for 6 months

        To maximize the efficiency of our experiments we excluded patients if they:

          -  Have participated in progressive resistance training or received pulsed
             electromagnetic field treatment in the prior year

          -  Exercise regularly more than once a week.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Hand Ultrasonography: Clinical and Functional Correlation in Symptomatic Osteoarthritis (OA) (NCT02324192)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of hand OA, according to the criteria of the American College of
             Rheumatology (ACR) (Altman et al., 1990) with involvement of proximal and / or distal
             IP joints

          -  More than 40 years old

          -  Visual analog scale of pain (VAS of 0-10 cm) in the joint of study between 3-8cm

          -  And agree and sign the Consent Term of the study.

        Exclusion Criteria:

          -  Changed the use of oral corticosteroids and nonsteroidal anti-inflammatory drugs in
             the last thirty days

          -  Changed the treatment of OA in the last two months (including drug and rehabilitation)

          -  Radiography of hands suggesting interphalangeal arthropathy of other etiology
             (psoriatic arthritis, microcrystalline arthropathy).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Telerehabilitation for Patients Diagnosed With Coronavirus (NCT04346927)

Eligibility criteria:
Inclusion Criteria:

          -  Having been diagnosed with COVID-19,

          -  Having been diagnosed in the last 1 week,

          -  Being between the ages of 18-70,

          -  Patients who continue to be followed at home

        Exclusion Criteria:

          -  Hospitalization patients

          -  Having a serious cognitive impairment

          -  Having serious hearing and vision problems
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study to Assess the Feasibility of Screening for SARS-CoV-2 Among Healthy Workers (NCT04405466)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy workers asymptomatic for SARS-CoV-2

          -  Ability to consent with the study and its procedures

          -  Age above 18 years old

          -  Full time employee on site at least 3 full working days a week

          -  Working in a shared office/lab/manufacturing environment where at least 3 employees
             are present and/or having frequent contact with others i.e reception area,
             transportation and delivery areas.

        Exclusion Criteria:

        Workers presenting symptoms that could be signs of a SARS-CoV-2 infection such as:

          -  fever ≥38°C

          -  chills

          -  fatigue

          -  muscle ache (myalgia)

          -  sore throat

          -  cough

          -  runny nose (rhinorrhea)

          -  shortness of breath (dyspnea)

          -  wheezing

          -  chest pain

          -  other respiratory Symptoms

          -  headache

          -  nausea/vomiting
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Healing of Post-ext Sites Using Bovine Bone Mineral: a CBCT and Histologic RCCT (NCT01800149)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy adult patients with one or more teeth to be extracted, from premolar to
             premolar

        Exclusion Criteria:

          -  Heavy smokers (more than 10 cig per day)

          -  Current Pregnant patients

          -  History of malignancy

          -  History of radiotherapy or chemiotherapy in the past 5 years

          -  Long term steroidal or antibiotic therapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Biodesign® Otologic Repair Graft (NCT04635228)

Eligibility criteria:
Inclusion Criteria:

          -  Patient requires tympanic membrane closure.

        Exclusion Criteria:

          -  Life expectancy < 12 months

          -  Known sensitivity to porcine material
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: POCUS: Hemostatic Potential and Joint Health in Patients With Severe Hemophilia A on Novel Replacement Therapies (NCT04690322)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with moderate hemophilia A (baseline factor VIII activity 1-5%) or severe
             hemophilia A (baseline factor VIII activity <1%) on prophylactic standard half-life
             FVIII infusions OR subjects with moderate or severe hemophilia A who have not started
             prophylactic treatment

          -  Less than 18 years of age

        Exclusion Criteria:

          -  Subjects with documented FVIII inhibitor

          -  Subjects with a history of ≥ 2 target joints

          -  Subjects with a history of synovectomy

          -  Currently using medications known to impact bone and mineral metabolism (e.g.,
             bisphosphonates, corticosteroids, estrogen, testosterone, calcitonin, thyroid hormone
             therapy);

          -  Disease states known to affect bone integrity (e.g., primary hyperparathyroidism,
             Paget's disease, clinically significant liver disease)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 17 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Benchmark Ear Impression Techniques (NCT03303183)

Eligibility criteria:
Inclusion Criteria:

          -  Only adult participants ≥ 18 years

          -  Informed consent form as documented by signature

          -  Ability to fill in a questionnaire conscientious

          -  Healthy outer ear (Pinna and ear canal, w/o previous surgical procedures)

        Exclusion Criteria:

          -  Contraindications to the MD in this study, e.g. known hypersensitivity or allergy to
             the investigational product

          -  Inability to follow the procedures of the study, e.g. due to language problems,
             psychological disorders, dementia, etc. of the participant
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Heat Application on Depression, Anxiety, Menstrual Attitude and Dysmenorrhea (NCT04572555)

Eligibility criteria:
Inclusion Criteria:

          -  the ages of 18-30,

          -  being nulliparous,

          -  having a VAS score of 2 and higher,

          -  not having a systemic or chronic disease

          -  not using hormonal contraceptives.

        Exclusion Criteria:

          -  using forms of analgesic and alternative treatments during the study

          -  experiencing menstrual irregularities
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 30 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Treatment of Covid-19 Using Infrared and/or Vitamin C (NCT04584437)

Eligibility criteria:
Inclusion Criteria:

          -  All humans seeking prevention or treatment of the COVID-19 pandemic.

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Clinical Procedures to Support Research in ALS (NCT03489278)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of ALS or a related disorder (e.g. primary lateral sclerosis, progressive
             muscular atrophy).

          -  Receiving care at a clinical center that uses Epic as its EHR.

          -  Able and willing to provide informed consent (or informed consent obtainable from a
             designated proxy).

        Exclusion Criteria:

          -  Inability to understand English and/or Spanish
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment