araag2/NLI4PR huggingface dataset:
Clinical trial: The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With Albinism (NCT02200263)

Eligibility criteria:
Inclusion Criteria:

          -  Age of 12 years old and older

          -  Clinical and/or genetic diagnosis of ocular or oculocutaneous albinism

          -  Ocular media allowing acceptable visualization of the retina.

          -  Ocular media allowing acceptable quality of the ocular coherence tomography (OCT)
             and/or fundus autofluorescence (FAF) scans.

          -  At least one reliable central macular pigment optical density (MPOD) measurement
             captured on the enrollment visit in at least one eligible eye

          -  Best corrected visual acuity of 20/200 or better in one or both eligible eyes (eyes
             that confirmed to be eligible by the MPOD testing).

        Exclusion Criteria:

          -  Persons taking lutein and/or zeaxanthin supplements over the past 6 months

          -  Pregnant or planning to become pregnant

          -  Evidence of present or past retinal macular condition other than congenital foveal
             hypoplasia

          -  History of gastrointestinal disease that would interfere with absorption of lutein and
             zeaxanthin

          -  Participation in a clinical trial requiring visual testing or administration of a drug
             (marketed or investigational) within 60 days before entry in the study (the day
             informed consent is signed)

          -  Inability to communicate or cooperate with the investigator due to cognitive
             impairment or poor general health

          -  Any other condition which, in the opinion of the investigators, is likely to interfere
             with the successful collection of the measures required for the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? Contradiction
Clinical trial: Light to Maximize Vision, Minimize Insomnia (NCT01712243)

Eligibility criteria:
Inclusion Criteria:

          -  Aged 55-85

          -  At least 20/200 corrected visual acuity

          -  Greater than 20° visual field with no lower visual field loss

          -  Stable health

          -  Male or female

          -  Normal color vision

          -  Normal hearing

        Exclusion Criteria:

          -  Extreme chronotype

          -  Sleep disorders

          -  Dementia

          -  Smoker

          -  Depression

          -  Alcohol abuse

          -  Use of illegal drugs

          -  Use of sleep/wake altering drugs on an acute or as needed basis (including
             nutraceuticals, antihistamines)

          -  Use of light sensitizing drugs

          -  Self-reported history of nocturia (>3 times per night)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 55 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient description (patient's own words): I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of the Laparoscopy-Assisted Distal Gastrectomy and Open Distal Gastrectomy for Advanced Gastric Cancer (NCT00741676)

Eligibility criteria:
Inclusion Criteria:

          -  Pathologic finding by gastric endoscopy: confirmed gastric adenocarcinoma

          -  Age: older than 20 year old, younger than 80 year old

          -  Cancer core: located at the middle or lower part of stomach

          -  Preoperative cancer stage (CT, GFS stage): cT2N0M0, cT2aN1M0, cT2bN1M0, cT3N0M0

          -  ASA score: ≤ 3

          -  Informed consent patients (explanation about our clinical trials is provided to the
             patients or patrons, if patient is not available)

        Exclusion Criteria:

          -  Concurrent cancer patients or patient who was treated due to other types of cancer
             before the patient was diagnosed as a gastric cancer patient

          -  Patient who was treated by other types of treatment methods, such as chemotherapy,
             immunotherapy, or radiotherapy

          -  Patient who was received upper abdominal surgery (except, laparoscopic
             cholecystectomy)

          -  Patient who was treated because of systemic inflammatory disease

          -  Pregnant patient

          -  Patient who suffer from bleeding tendency disease, such as hemophilia or patient
             taking anti-coagulant medication due to deep vein thrombosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Expanded Access Protocol of BHV-0223 for Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT03537807)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with diagnosed ALS of any type or duration

          -  Current or previous treatment with oral riluzole tablets, or patients who have never
             taken riluzole oral tablets, or patients who have successfully completed a clinical
             trial with BHV-0223 and were not withdrawn prematurely due to adverse events

          -  Swallowing difficulties, or patient or caregiver report choking one or more times per
             week, or investigator deems appropriate to treat with sublingual BHV-0223 because
             (s)he deems the patient cannot be satisfactorily treated with Rilutek®

          -  Adequate hepatic function

        Exclusion Criteria:

          -  Patient with history of severe hypersensitivity reaction to riluzole oral tablets or
             BHV-0223

          -  Patient is known to have any other acute or chronic liver disease
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of Postoperative Inguinal Pain Between the Onstep Technique and the Lichtenstein Technique (NCT04138329)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of unilateral inguinal hernia.

          -  Male or Female.

          -  Older tan 16 years.

          -  Accept to participate in the study.

        Exclusion Criteria:

          -  Chronic Obstructive Pulmonary Disease.

          -  Obesity.

          -  Diabetes Mellitus.

          -  Cirrhosis.

          -  Diseases involving collagen deficiency.

          -  Previous surgery in the groin.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Laparoscopic Inguinal Hernia Repair in Infancy and Childhood (NCT02239185)

Eligibility criteria:
Inclusion Criteria:

        Bilateral congenital inguinal hernia (CIH), recurrent cases, unilateral cases with
        questionable other side, parental request and cases with CIH associated with umbilical
        hernia.

        Exclusion Criteria:

        Hernia of canal of Nuck in females, Inguinal hernia with undescended testis, Parental
        refusal, Contraindications for laparoscopy as lower major abdominal surgery
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 3 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Management of Sleep Apnoea Syndrome (SAS) in Patients With Vasovagal Syncope (VVS) (NCT04294524)

Eligibility criteria:
Inclusion Criteria:

          -  Obstructive sleep apnoea syndrome (>15 respiratory micro awakenings per hour of sleep)
             with an indication for treatment

          -  Recurring vasovagal syncope episodes defined as follows: at least three vasovagal
             syncopes during the last two years - OR- symptoms of orthostatic intolerance occurring
             in the last 6 months (Symptoms are triggered by orthostatism and can include malaises
             without loss of consciousness, asthenia, dizziness, visual disturbances, tinnitus,
             palpitations, headache, limitations of physical activity)

        Exclusion Criteria:

          -  Pathology that may explain syncope symptoms

          -  Cardiopathy

          -  Known disautonomia

          -  Hypotension of known origin

          -  Adrenal insufficiency

          -  Thyroid disorder

          -  History of sudden death in a first degree family member
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Contradiction
Clinical trial: Treadmill Training and Orthotic Use in Infants With Down Syndrome (NCT00825175)

Eligibility criteria:
Inclusion Criteria:

          -  Trisomy 21

          -  Able to pull to stand but not walk

        Exclusion Criteria:

          -  Additional developmental diagnoses

          -  Uncorrected vision or hearing impairments

          -  Previous orthotic intervention

          -  Previous treadmill intervention
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 36 Months

Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Clinical Utility of Pediatric Whole Exome Sequencing (NCT03525431)

Eligibility criteria:
Inclusion Criteria:

          1. Presenting clinical features suggestive of a genetic etiology, including intellectual
             disability, seizures, multiple congenital anomalies, metabolic conditions, and
             neurodegenerative conditions or idiopathic cerebral palsy.

          2. A minimum of one biological parent is available and willing to provide a specimen for
             WES, with a preference for two available parents. At least one parent consenting to
             WES of the child.

        4. Pediatric patients must have had at least one prior genetics appointment or evaluation
        5. Pediatric patients may have had a single nucleotide polymorphism (SNP) array or
        oligonucleotide array that did not provide a diagnosis.

        Exclusion Criteria:

          1. Prior WES performed for a clinical or research indication

          2. Lack of phenotypic indication of a likely underlying genetic etiology

          3. Both biological parents are unavailable.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Clinical Database and Biobank of Patients With Inflammatory Myopathies: the MASC Project (Myositis, DNA, Serum, Cells) (MASC) (NCT04637672)

Eligibility criteria:
Inclusion Criteria:

          -  All patients who had a confirmed (muscular biopsy, electromyogram, magnetic resonance
             imaging) or suspected clinically myositis. Myositis criteria are as follow:

               -  Dermatomyositis or polymyositis according to Bohan and Peter criteria (1975)

               -  Body inclusion myositis according to Griggs et al. criteria (1995)

               -  Necrotizing autoimmune myopathy according to Hoogendijk et al. criteria (2004)

               -  Drug-induced myositis

          -  Signature of the informed consent form for the study and for the biobank

          -  Age over 18 years old

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient description (patient's own words): I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Does the patient match the trial criteria? Entailment