araag2/NLI4PR huggingface dataset:
Clinical trial: Pulsed Dye Laser and Intense Pulsed Light (IPL) for the Treatment of Telangiectasia and Skin Redness (NCT00206921)

Eligibility criteria:
Inclusion Criteria:

          -  18 years or older

          -  Skin types I, II, III

          -  No previous laser or IPL treatment for the condition

        Exclusion Criteria:

          -  Younger than 18 years old

          -  Skin types IV, V, or VI

          -  Pregnant or lactating women

          -  Previous laser or IPL treatment for the condition

          -  Recent exposure to sun or sun-beds

          -  Treatment with oral retinoid within 6 months

          -  Tendency to produce hypertrophic scars or keloids
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Gastropanel for Gastric Atrophy and Cancer Risk Assessment (NCT02114411)

Eligibility criteria:
Inclusion Criteria:

          -  Adult females and males over 45 years of age with dyspeptic symptoms (epigastric pain,
             bloating and epigastric discomfort)

        Exclusion Criteria:

          -  Patients who require surgery or immediate follow-up treatment for major symptoms,
             including hematemesis, melena, acute epigastric pain

          -  Patients who previously underwent upper gastrointestinal surgery

          -  Patients with diabetes

          -  Pregnant women

          -  Subjects who refuse to participate or are unable to give consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Stress Response Using Thin and Standard Size Endoscopy. (NCT00273130)

Eligibility criteria:
Inclusion Criteria:

          -  diagnostic gastroscopy, age over 18, danish speaking,

        Exclusion Criteria:

          -  use of beta blocking or any other heart rate modulating drug, antithyroid drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Respiratory Variations For Assessing Blood Withdrawal (NCT03066414)

Eligibility criteria:
Inclusion Criteria:

          -  adult patients of > or equal 18 years

          -  genetic hemochromatosis

          -  undergoing a therapeutic blood withdrawal

          -  health insured

          -  non-obese (body mass index <30Kg/m²)

        Exclusion Criteria:

          -  pregnancy

          -  transthoracic echogenicity unsuitable for measuring the inferior vena cava diameters

          -  clinical signs of active exhalation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effect of MAXOMAT ® on the Growth of Small Children to NOONAN's Syndrome (NCT00452725)

Eligibility criteria:
Inclusion Criteria:

          -  Children and adolescents with Noonan's syndrome with a height < -2 SD and no
             progressive cardiopathy

        Exclusion Criteria:

          -  Age < 3 years

          -  Height ≥ -2 SD

        The above information is not intended to contain all considerations relevant to a patient's
        potential participation in a clinical trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 15 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of Ataluren (PTC124) in Hemophilia A and B (NCT00947193)

Eligibility criteria:
Inclusion Criteria:

          -  Ability to provide written informed consent

          -  Age ≥18 years

          -  Presence of a nonsense mutation as the sole disease-causing mutation in the FVIII or
             FIX gene

          -  At least 20 prior treatments with FVIII or FIX concentrates

          -  Willingness and ability to comply with scheduled visits, drug administration plan,
             study restrictions, and study procedures

        Exclusion Criteria:

          -  Known hypersensitivity to any of the ingredients or excipients of the study drug

          -  Any history of prior anti-FVIII/FIX inhibitors

          -  Unable or unwilling to forego prophylactic FVIII/FIX concentrate use during the
             screening and on-study periods (Note: Participants were allowed use of FVIII/FIX
             concentrates for treatment of bleeding episodes while on study)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Ultrasonography in Hemophilic Joint Disease and Serum Markers (NCT02634918)

Eligibility criteria:
Inclusion Criteria:

          1. All children ages 6 months - 18 years with hemophilia A or B

          2. Hemophilia subjects with and without a history of hemarthroses including target joints
             ( joint of interest) and joints without documented bleeds( control joints)

          3. Hemophilia subjects with a history of inhibitor to FVIII or FIX and documented
             hemarthroses

          4. History of hemarthroses more than 4 weeks prior to study enrolment to allow for
             resolution of hemarthroses which could affect detection of synovial and cartilage
             changes

        Exclusion Criteria:

          1. Bleeding disorder subjects without a diagnosis of hemophilia

          2. Hemophilia subjects with any underlying illness such as liver or renal disease or any
             systemic illness such as diabetes or any other chronic illness apart from the
             hemophilia

          3. Hemophilia subjects on medications which could increase bleeding risk such as non
             steroidal anti inflammatory agents, anti seizure medications apart from factor
             concentrates

          4. History of hemarthroses within the 4 weeks prior to study enrolment
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 18 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Aerobic Fitness in Overweight and Obese Individuals (NCT03854786)

Eligibility criteria:
Inclusion Criteria:

          -  Body Mass Index ≥ 25 - ≤ 34.9 kg/m2.

          -  Waist Circumference ≥ 80 cms.

          -  Non-smoker.

          -  BP ≤ 140/90 mm Hg

          -  FBS ≤ 125 mg/dl

          -  Hb ≥ 11 g/ dl

          -  Can abstain from strenuous exercise and alcohol for at least 48 hours.

          -  Can abstain from caffeine for at least 24 hours.

        Exclusion Criteria:

          -  Participants with history of regular (≥2 times a week) structured exercise (gym,
             walking, yoga, etc).

          -  Inter-arm blood pressure is ≥10 mm Hg.

          -  Known cases of type II Diabetes Mellitus.

          -  Known cases of hypertension with or without anti-hypertensive medication.

          -  Visual or balance problems, or who cannot walk on a treadmill without using the
             handrails.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Surveillance of Patients With Precancerous Lesions of the Stomach (NCT03250091)

Eligibility criteria:
Inclusion Criteria:

        Patients undergoing upper endoscopy Motivation to participate in the study Signed consent

        Exclusion Criteria:

        Known gastric cancer Unwillingness or inability to co-operate
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Predictive Equations for Resting Energy Expenditure (NCT02435888)

Eligibility criteria:
Inclusion Criteria:

          -  Women treated in an endocrinology centre specialising in hyperandrogenism at the
             university hospital of University Federal of Minas Gerais (Belo Horizonte, Minas
             Gerais, Brazil)

          -  The patients were of reproductive age (range: 18-45 years)

          -  were overweight or obese (Body mass index ≥ 25.0 kg/m2) and

          -  signed an informed consent statement

        Exclusion Criteria:

          -  Women who were pregnant,

          -  were lactating,

          -  had a diagnosis of hypothyroidism or hyperthyroidism or

          -  had high physical activity levels were excluded from the sample.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy and Safety of Pemigatinib in Participants With Solid Tumors With FGFR Mutations or Translocations (FIGHT-208) (NCT04003623)

Eligibility criteria:
Inclusion Criteria:

          -  Histologically or cytologically confirmed solid tumor malignancy that is advanced or
             metastatic (Stage IIIB or IV) or is surgically unresectable.

          -  Radiographically measurable disease (per RECIST v1.1 or RANO for primary brain
             tumors).

          -  Documentation of an FGFR1-3 gene mutation or translocation.

          -  Objective disease progression after at least 1 prior therapy.

          -  Not eligible or able to participate in any other Incyte-sponsored clinical trial.

        Exclusion Criteria:

          -  Advanced/metastatic bladder cancer or advanced/metastatic cholangiocarcinoma.

          -  Prior receipt of a selective FGFR inhibitor.

          -  Current evidence of clinically significant corneal or retinal disorder.

          -  History of calcium and phosphate hemostasis disorder or systemic mineral imbalance
             with ectopic calcification of soft tissues.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Indoor Woodsmoke PM and Asthma (NCT00807183)

Eligibility criteria:
Inclusion Criteria:

          -  children with moderate to severe asthma living in homes with non EPA-certified
             woodstove used for heating.

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction