araag2/NLI4PR huggingface dataset:
Clinical trial: Fertility After Transvaginal Surgery or Uterine Artery Embolization Combined With Uterine Curettage in Patients With Cesarean Scar Pregnancy (NCT02933190)

Eligibility criteria:
Inclusion Criteria:

          -  increased levels of serum β-hCG and ultrasonography findings. The criteria for
             diagnosis by ultrasonography was the presence of the following: (1) an empty uterine
             cavity and endocervical canal; (2) detection of the placenta and/or a gestational sac
             embedded in the hysterectomy scar; (3) the presence of the gestation sac with or
             without a fetal pole and with or without fetal cardiac activity (depending on the
             gestational age) in the anterior part of the uterine isthmus; and (4) a thin (1-3 mm)
             or absent myometrial layer between the gestational sac and the bladder(24). All
             patients had taken Magnetic Resonance Imaging (MRI) to clarify the diagnosis .
             Pregnancy tissues were identified by histopathology examinations of the surgical
             tissues.

        Exclusion Criteria:

          -  All enrolled patients had no contraindications for transvaginal surgery or UAE,
             including renal failure, active pelvic infection, clotting disorders, or known allergy
             to the contrast material.
Female
No healthy subjects accepted to join the trial.



Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Confocal Endomicroscopy for Non-Erosive Reflux Disease (CE NERD) (NCT02039869)

Eligibility criteria:
Inclusion Criteria:

        1. Individuals with reflux disease between the ages of 18 and 79 who have failed a trial of
        daily PPI.

        Exclusion Criteria:

          1. Barrett's esophagus

          2. Use of high dose proton pump inhibitor within 4 weeks of study entry

          3. Esophageal varices

          4. Coagulopathy

          5. GI cancer or mass

          6. Previous surgery involving the esophagus, stomach or duodenum

          7. Pregnancy

          8. Allergy to either sucralfate or proton pump inhibitors
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 79 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Knee Malalignment and Thigh Muscle Strengthening in Individuals With Medial Knee Arthritis (NCT00414557)

Eligibility criteria:
Inclusion Criteria:

          -  Pain in the knee

          -  Osteophytes on knee x-ray

          -  Self-reported pain on the inner aspect of the study knee

          -  Osteophytes in the medial compartment of the knee joint and

          -  Medial joint space narrowing greater than lateral joint space narrowing on x-ray

        Exclusion Criteria:

          -  Knee surgery within the previous 6 months

          -  History of lower limb joint replacements

          -  Systemic arthritic conditions such as rheumatic or psoriatic arthritis

          -  Valgus knee deformity (> 5º)

          -  Inability to walk without the use of walking aids

          -  Intending to start a lower limb strengthening program in the next 3 months

          -  Seeking or currently receiving physiotherapy for OA knee
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Ovarian Stimulation Using Recombinant Follicle-stimulating Hormone (FSH) and Gonadotrophin Releasing Hormone (GnRH) Agonist in Alternate Days (NCT01468441)

Eligibility criteria:
Inclusion Criteria:

          -  women of good physical and mental health

          -  under 37 years old, with regular menstrual cycles of 25-35 days

          -  normal basal FSH and LH levels

          -  BMI less than 30 kg/m2

          -  presence of both ovaries and intact uterus

          -  absence of polycystic ovaries

          -  endometriosis, or gynaecological / medical disorders and a negative result in a
             screening for sexually transmitted diseases

          -  all patients signed a written informed consent form

          -  no patient had received any hormone therapy for at least 60 days preceding the study.
Female
No healthy subjects accepted to join the trial.

Subject must be at most 35 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pretreatment With Norethindrone Acetate Prior to Levonorgestrel IUS Insertion for Heavy Menstrual Bleeding (NCT01391052)

Eligibility criteria:
Inclusion Criteria:

          -  You must be between 18-45 years old

          -  You have Heavy Periods

        Exclusion Criteria:

          -  You are pregnant

          -  You are currently using hormonal contraception or hormonal therapy

          -  You have a history of pelvic inflammatory disease (and have not had a normal pregnancy
             since)

          -  You had an infected abortion within the last three months

          -  You have abnormal or cancerous cells of the cervix or uterus

          -  You have an actine infection in your genital organs

          -  Known or suspected breast cancer

          -  Active liver disease or tumors

          -  Allergy to levonorgestrel or norethindrone

          -  You currently have deep vein thrombosis, pulmonary embolism, or history of these
             conditions

          -  you currently have active or recent (within the past year) arterial thromboembolic
             disease (such as a stroke or myocardial infarction) these conditions
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Entailment
Clinical trial: Internet-delivered ACT for Treating the Psychological Effects of Hearing Loss (NCT02877329)

Eligibility criteria:
Inclusion Criteria:

          -  HHIE-S score over 8

          -  Indication of comorbid psychological suffering/distress (defined as total score above
             0 on PHQ9/GAD7 or below 1sd on QOLI)

        Exclusion Criteria:

          -  No computer with internet connection

          -  Unability to understand written content

          -  Incomplete screening procedure

          -  A health condition that needs immediate care
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 110 Years

Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment
Clinical trial: The Utility of Nexium in Chronic Cough and Reflux Disease (NCT00287339)

Eligibility criteria:
Inclusion Criteria:

          1. males and females (of non-childbearing potential. ie-surgically sterile, or willing to
             use an approved form of birth control) between the ages of 18 and 70 who speak and
             write in English,

          2. chronic cough (> 8 wks/another article used > 6 wks) with symptom severity criteria of
             2 or greater on the Fisman Cough Severity Score and 3 or greater or the Fisman Cough
             Frequency Score, and,

          3. failure to respond to post nasal drip therapy.

        Exclusion Criteria:

          1. abnormal chest x-ray,

          2. patients taking H2 blockers within the previous 3 days or PPI's within the previous 7
             days,

          3. failure to respond to past PPI therapy given for cough that lasted at least 12 weeks,

          4. use of an investigational drug within the past 30 days,

          5. previous surgical antireflux or non-surgical endoscopic anti-reflux procedure (ex.,
             Stretta or endoscopic sewing device),

          6. previous aerodigestive malignancy,

          7. current smokers, or ex-smokers (defined as those who quit smoking less than 3 months
             prior to study enrollment or those who have quit, but have a 20 pack year smoking
             history),

          8. upper respiratory infection within 8 weeks prior to study enrollment,

          9. current use of a B- blocker, ACE-I, or anticholinesterases at time of enrollment.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: A Follow On Community Testing Study To Evaluate The Performance of the Lucira COVID-19 All-In-One Test Kit (NCT04720235)

Eligibility criteria:
Inclusion Criteria

          1. Ages 14-75

          2. Must be able to read and write in English

          3. Must be willing to try rapid COVID-19 test and self-collect a nasal swab sample in
             both nostrils

        Exclusion Criteria

          -  Currently suffering from nasal trauma such as a nosebleed

          -  Received a nasal rinse/wash/aspirates in past 12 hours

          -  Currently experiencing any of the CDC COVID-19 symptoms:

               -  Fever

               -  Cough

               -  Shortness of breath or difficulty breathing

               -  Fatigue

               -  New loss of taste or smell

               -  Muscle or body aches

               -  Headache

               -  Sore throat

               -  Congestion or runny nose

               -  Nausea or vomiting

               -  Diarrhea
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 14 Years old.
Subject must be at most 75 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effect of Eating Pulses for 8 Weeks on Satiety and Metabolic Syndrome Risk Factors in Overweight Individuals (NCT00604448)

Eligibility criteria:
Inclusion Criteria:

          -  overweight/obese adults

          -  body mass index: 27-35 kg/m2

          -  individuals not prescribed medications over the past 6 months that could interfere
             with the study outcomes (i.e. statins or metformin)

        Exclusion Criteria:

          -  smokers

          -  those on an energy restricted diet

          -  breakfast skippers

          -  pregnant/lactating women
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Nailfold Capillaroscopy Evaluation in Cushing Syndrome Patients (NCT04433819)

Eligibility criteria:
Inclusion Criteria:

          -  Male and female patients diagnosed as Cushing syndrome (CS) caused by ACTH-producing
             pituitary adenoma or cortisol producing adrenal adenoma

          -  Age between 18 and 70 years

        Exclusion Criteria:

          -  Chronic glucocorticoid use

          -  CS caused by ectopic ACTH producing tumors

          -  CS caused by adrenocortical carcinoma

          -  Pseudo CS

          -  Patients with Raynaud phenomenon

          -  Patients with collagen tissue disease

          -  Patients who use drugs that affect the metabolism of fibrinolysis (such as oral
             contraceptives)

          -  Employees at work at risk of microtrauma (such as gardeners, farmers)

          -  Skin diseases with nail fold involvement (such as dermatitis, psoriasis)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Contradiction