araag2/NLI4PR huggingface dataset:
Clinical trial: Financial Incentives for Low Socioeconomic Diabetic Patients (NCT03506230)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of type 2 diabetes for at least 6 months

          -  Diabetes for a maximum of ten years

          -  Updated HbA1c level of between 8.5 and 11% from the last month

          -  Agreement to participate and sign an informed consent

        Exclusion Criteria:

          -  Pregnancy

          -  Insulin therapy

          -  Psychiatric disorder from the first or second line according to the Diagnostic and
             Statistical Manual of mental disorders (DSM)

          -  Active oncology disease [excluding squamous cell carcinoma (SCC) and basal cell
             carcinoma (BCC)

          -  Planed bariatric surgery for the next 6 months

          -  Cardiac hospitalization in the previous year

          -  A severe hypoglycemia event three months prior to allocation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Double Stimulation in Women With Low Prognosis in ART (NCT04531644)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≤ 40.

          -  AMH ≥ 0.3 ng/ml and ≤ 1.2 ng/ml.

          -  OR 3 ≤ AFC ≤7.

          -  Normal shape of uterus (based on ultrasound).

          -  Body mass index within 28 - 37 kg/m2

        Exclusion Criteria:

          -  Asherman's syndrome.

          -  Endometriosis.

          -  Leiomyomas distorting the endometrium

          -  Sperm extracted from surgical procedures (i.e. PESA, TESE).

          -  Patients refuse to continue participating in the study.

          -  Patients injected with wrong dose of gonadotropins during the treatment.

          -  Serious complications or accidents arise forcing the patients to discontinue the
             treatments.

          -  Ovarian surgery

          -  Previous chemotherapy or pelvic irradiation
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Lyme Disease (NCT04148222)

Eligibility criteria:
Inclusion Criteria:

          1. Signed informed consent, demonstrating that the patient understands the procedures
             required for the study and the purpose of the study

          2. Male or female patients of any age (interest is given to children to compare with
             mothers)

          3. Diagnosis of Lyme Disease

        Exclusion Criteria:

          1. Refusal to sign informed consent form

          2. History of bariatric surgery, total colectomy with ileorectal anastomosis or
             proctocolectomy.

          3. Postoperative stoma, ostomy, or ileoanal pouch

          4. Participation in any experimental drug protocol within the past 12 weeks

          5. Treatment with total parenteral nutrition

          6. Any clinically significant evidence of disease that could interfere with the subject's
             ability to enter the trial

          7. Inability to adequately communicate with the investigator or their respective designee
             and/or comply with the requirements of the entire study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? Entailment
Clinical trial: Post Covid-19 Cardiopulmonary and Immunological Changes (NCT04388436)

Eligibility criteria:
Inclusion Criteria:

          -  pcr positive for covid -19 who are survived

        Exclusion Criteria:

          -  dead patient uncooperative
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Total Laparoscopic Hysterectomy vs Minilap Hysterectomy (NCT03251677)

Eligibility criteria:
Inclusion Criteria:

          -  Mobile uterus.

          -  Uterine size up to 12 weeks gestation.

          -  Benign lesions.

        Exclusion Criteria:

          -  Enlarged uterus > 12 weeks gestation.

          -  Suspected malignancy.

          -  Large adnexal masses.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effects of Infant Massage on Acceptance, Commitment and Conscience of Influence of Parents With Down Syndrome Babies (NCT03126734)

Eligibility criteria:
Inclusion Criteria:

          -  Parents with babies with Down Syndrome between 4 and 8 months old.

        Exclusion Criteria:

          -  Parents with babies without Down Syndrome.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? Entailment
Clinical trial: Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE) (NCT03072940)

Eligibility criteria:
Inclusion Criteria:

        - idiopathic RBD (criteria of the international classification of sleep disorders-3)

        For healthy controls : no neurologic or psychiatric disorder

        Exclusion Criteria:

          -  Contraindication to MRI

          -  Do not speak French
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? Contradiction
Clinical trial: Kinematic-guided BoNT-A Treatment for ET and PD Tremor (NCT02427646)

Eligibility criteria:
Inclusion Criteria:

          -  Consenting male and female participants, aged 18 years to 80 years

          -  PD individuals diagnosed by UK Brain Bank Criteria with stage H&Y2-3 disease or ET
             with hand tremor in their motor dominant hand

          -  Stable IPD/ET medication management for the 6 month duration prior to their enrollment
             in the study

          -  Individuals with IPD will be eligible for the study only if tremor is their primary
             and most bothersome symptom as determined by clinical exam and patient report

          -  Participants who are botulinum toxin naïve for tremor management

        Exclusion Criteria:

          -  History of stroke

          -  Muscle weakness or any related compartmental muscle syndrome

          -  Smoking

          -  Offending medications (Lithium, valproate, steroids, amiodarone, beta-adrenergic
             agonists (e.g. salbutamol))

          -  Contradictions per the Xeomin® drug monograph

          -  Patients prescribed zonisamide
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Gait and REM Sleep Behavior Disorder (NCT02554331)

Eligibility criteria:
Inclusion Criteria:

          -  Specific inclusion criteria for RBD patients - to reach the diagnosis criteria of RBD
             (International Classification of Sleep Disorders 2)

          -  Specific inclusion criteria for PD patients - to reach the diagnosis criteria of
             idiopathic PD (Queen Square Brain Bank) - Hoehn Yahr score ≤ 2

        Exclusion Criteria:

          -  Specific exclusion criteria for RBD patients - diagnosis of PD - other pathology
             associated to RBD diagnosis - presence of antiparkinsonism medication

          -  Specific exclusion criteria for PD patients - clinical signs of parkinsonian syndrome-
             Mini Mental State Examination < 24/30- gait disorder clinically observable

          -  Specific exclusion criteria for controls - neurological disease- gait disorder
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? Entailment
Clinical trial: Baricitinib Therapy in COVID-19 (NCT04358614)

Eligibility criteria:
Inclusion Criteria:

          -  SARS-Co-V2 positivitity to the nasal-swab by reverse-transcriptase-polymerase chain-
             reaction (RT-PCR) assay tested by the local diagnostic laboratory

          -  Age >18 and <85 years

          -  Presence of at least 3 of the following symptoms as present fever, cough, myalgia,
             fatigue.

          -  Presence of radiological findings of pneumonia assessed by chest radiograph, computed
             tomography, or pulmonary ultrasound.

          -  Peripheral capillary oxygen saturation (SpO2) > 92% on room air at screening

          -  PaO2/FiO2 >100-300 mmHg at arterial blood gas analysis.

        Exclusion Criteria:

          -  Age < 18 and >85

          -  History of thrombophlebitis

          -  Latent tuberculosis infection (based on the positivity to QuantiFERON Plus positivity,
             Qiagen, Germany)

          -  Pregnancy and lactation

          -  History of malignancies over the previous 5 years, current diagnosis of malignancy

          -  Inability or unwillingness to sign a written consent.

          -  Transaminases values 4-fold higher than the upper normal limit.

          -  HBV and HCV positivity.

          -  Current Herpes zoster infection.

          -  Evidence of concomitant bacterial infections.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Cardiovascular Responses to Static and Dynamic Exercise in Elderly With Isolated Systolic Hypertension (NCT02270216)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects should be over 60 years of age with essential isolated systolic hypertension
             (stage I-II base on recommendation of JNC-VII) for the hypertension group and normal
             blood pressure in the healthy group. Good communication, independent physical
             activity. The healthy subject should be non-smokers, non-obese, free of any signs or
             symptoms of disease as revealed by medical history

        Exclusion Criteria:

          -  Essential hypertension stage III or secondary hypertension, any history of respiratory
             disease, heart disease, renal disease, blindness, cerebrovascular disease, exercise
             limited by pain
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction