araag2/NLI4PR huggingface dataset:
Clinical trial: Treatment Response of Maintenance Dose of Proton Pump Inhibitor in Patients With Nonerosive Gatroesophageal Reflux Disease (NCT03436914)

Eligibility criteria:
Inclusion Criteria:

          -  Patient over 19 years old

          -  Patient with typical GERD symptom (heartburn or acid reflux more than once a week)

        Exclusion Criteria:

          -  Patient who received EGD since the past 6 months, and diagnosed as GERD endoscopically

          -  Patient with active gastric/duodenal ulcer

          -  Patient who received esophagus, stomach or duodenum surgery

          -  Patient with hypersensitivity to esomezol®

          -  Patient with no achieved agreement on the study from the guardian or patient himself.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Validation of a Smartphone-Based Hearing-in-Noise Test (HearMe) (NCT03429777)

Eligibility criteria:
Inclusion Criteria:

          -  Age-matched (18-100)

          -  Healthy normal controls with no known hearing loss

          -  Patients with clinically assessed hearing loss

        Exclusion Criteria:

          -  Complete hearing loss/deafness

          -  Cognitive decline or dysfunction, dementia
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment
Clinical trial: Application of a Systematic Developmental Assessment to a Novel Population: Infants With Rare Genetic Disorders (NCT03967743)

Eligibility criteria:
Inclusion Criteria:

          -  Eligible patients are infants under 4 years of age with genetic disorders undergoing
             developmental surveillance in the NICU GraDS program.

        Exclusion Criteria:

          -  Children 4 years of age or older will be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 4 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Entailment
Clinical trial: Genetics of Mendelian Forms of Young Onset Alzheimer Disease (NCT01622894)

Eligibility criteria:
Inclusion Criteria:

          -  > in one family 2 cases of Alzheimer disease with age of onset under 65

        Exclusion Criteria:

          -  other cases of young onset dementia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: The Hemophilia Ultrasound Project (NCT02807753)

Eligibility criteria:
Inclusion Criteria:

          -  Severe Hemophilia Cohort:Patients from 0 up to 30 months of age with diagnosis of
             severe hemophilia A or B defined as a factor VIII:C/IX:C of <1% undergoing prophylaxis
             regimen with any factor VIII or IX concentrate and without evidence (clinical or by
             history) of target joint disease.

          -  Mild/moderate Hemophilia Cohort:Patients from 0 up to 30 months of age with diagnosis
             of mild hemophilia A or B defined as a factor VIII:C/IX:C of 5-50% and those with
             diagnosis of moderate hemophilia A or B defined a s a factor VIII:C/IX:C of 1-5%
             without evidence (clinical or by history) of target joint disease and no history of
             spontaneous joint bleeds.

        Exclusion Criteria:

          -  Patients with concomitant Hepatitis B, Hepatitis C and HIV viral infections (because
             of a recognized arthritogen effect).

          -  Present or prior history of anti FVIII or IX inhibitors.

          -  Known inflammatory joint disease.

          -  Established target joint.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 30 Months

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Prediction of Clinical Course in COVID19 Patients (NCT04377685)

Eligibility criteria:
Inclusion Criteria:

          -  age ≥ 18 years

          -  clinical suspicion of COVID-19 confirmed by RT-PCR

          -  CT scan at ER admission

          -  RT-PCR sampling

        Exclusion Criteria:

          -  CT scan failure or loss of CT data

          -  RT-PCR initial results unavailable
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Miromatrix Biological Mesh for Hiatal Hernia Repair (NCT02436681)

Eligibility criteria:
Inclusion Criteria:

          -  between 18 and 80 years old on the day of study enrollment

          -  able and willing to sign the consent form and comply with all study visits and
             procedures

          -  able to undergo elective laparoscopic hiatal hernia repair

          -  free of cognitive or speech impairment

          -  documented, symptomatic type II or III hernia ≥5cm in the axial/vertical dimension

          -  commit to non-smoking for at least 4 weeks prior to procedure

        Exclusion Criteria:

          -  previous operation of the esophagus or stomach

          -  sensitivity to porcine material

          -  pregnant or plan to be pregnant within next 2 years

          -  immunocompromised or at risk of immunosuppression (i.e. be HIV positive, be
             experiencing organ rejection, be a recent or anticipated chemotherapy recipient) as
             determined by the Investigator

          -  require emergent operation for acute gastric volvulus or strangulation

          -  American Society of Anesthesiology (ASA) class 4 or greater

          -  BMI ≥40

          -  life expectancy of less than 2 years at the time of enrollment

          -  associated gastrointestinal disease that requires extensive medical or surgical
             intervention that might interfere with the quality of life assessment (e.g. Crohn's
             disease)

          -  any condition in the opinion of the Investigator that would preclude the use of the
             study device, or preclude the subject from completing the follow-up requirements
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Phase 2 Dose-finding Study to Evaluate the Effects of BA058 in the Treatment of Postmenopausal Women With Osteoporosis (NCT00542425)

Eligibility criteria:
Primary Inclusion Criteria:

          -  The patient has a bone mineral density T-score ≤ 2.5 at the lumbar spine or hip
             (femoral neck) by dual energy x-ray absorptiometry (DXA). Women with a bone mineral
             density T-score of 2.0 or lower and a prior low-trauma forearm, humerus, vertebral,
             sacral, pelvic, hip, femoral, or tibial fracture within the past 5 years, or who have
             an additional risk factor such as age 65 or greater or a strong maternal history of
             osteoporosis defined as a fracture related to osteoporosis or osteoporosis itself as
             determined by BMD criteria, are also study candidates.

          -  The patient is in good general health as determined by medical history and physical
             examination and is without evidence of clinically significant abnormality in the
             opinion of the Investigator.

        Primary Exclusion Criteria:

          -  History of bone disorders (e.g., Paget's disease) other than postmenopausal
             osteoporosis.

          -  Prior treatment with approved or as yet unapproved bone-acting investigational agents.

          -  History of carcinoma, nephrolithiasis or urolithiasis within the past five years or
             osteosarcoma at any time.

          -  History of radiotherapy (radiation therapy).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effects of Omega-3 Fatty Acid (OMACOR) on the Low-density Lipoprotein (LDL) Sub-fraction in Type 2 Diabetic Patients (NCT00758927)

Eligibility criteria:
Inclusion Criteria:

          -  Agreed for informed consent

          -  Age between 40-70 years old

          -  Type 2 diabetes mellitus

          -  Combined hyperlipidemia

          -  Serum triglyceride level between 200-500(mg/dl)

          -  No sudden change of glucose lowering therapies during trial, anticipated

        Exclusion Criteria:

          -  Hypersensitivity to OMACOR(Omega-3 fatty acid)

          -  Alcoholics

          -  Pregnancy

          -  Proliferative diabetic retinopathy

          -  Patients already taking fibrates

          -  Enrolled in other clinical trials during the recent 3 months

          -  Severe ischemic heart disease, liver disease, neurological disease

          -  AST/ALT level 2 folds above the normal reference level

          -  Psychiatric disorder not adequately controlled

          -  Serum creatinine over 2.0 (mg/dl)

          -  Previous pancreatic surgery

          -  Patients who can not maintain regular diet
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Anomalies of Dense Platelet Granules (NCT04095715)

Eligibility criteria:
Inclusion Criteria:

          -  Adult or child patient ≥ 2 years

          -  Having a hemorrhagic score ISTH > 3 for men, > 5 for women and > 2 for children.

          -  With no abnormal coagulation (defined by normal TP and TCK or activity ≥ 50% of FII,
             FV, FVII, FX, FVIII, FIX, FXI)

          -  no deficiency of Willebrand factor (defined by a cofactor activity with Ristoctin
             (VWF: RCo < 50%))

          -  no a known major thrombocytopenia/thrombopathy linked to a deficiency of one of the
             major platelet receptors

          -  Information of the patient and/or his legal representative present

        Exclusion Criteria:

          -  Inability or refusal of compliance with research requirements

          -  Thrombocytopenia < 100 G/L

          -  Treatments interfering with platelet functions within 10 days prior to inclusion

          -  Malignant hemopathy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction