araag2/NLI4PR huggingface dataset:
Clinical trial: A Study To Evaluate The Safety And Efficacy Of Atorvastatin In Patients With Diabetes And High Cholesterol (NCT00645424)

Eligibility criteria:
Inclusion Criteria:

          -  Adult Taiwanese outpatients with type 2 diabetes mellitus and high cholesterol

          -  Hemoglobin A1c levels of ≤10%, LDL-C levels of ≥130 mg/dL, and serum triglyceride
             levels of <400 mg/dL

        Exclusion Criteria:

          -  Type I diabetes mellitus

          -  Secondary causes of high cholesterol

          -  Elevated liver enzymes
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study of Recombinant AAV2/6 Human Factor 8 Gene Therapy SB-525 (PF-07055480) in Subjects With Severe Hemophilia A (NCT03061201)

Eligibility criteria:
Inclusion Criteria:

          -  Male ≥18 years of age

          -  Severe hemophilia A (past evidence of circulating FVIII activity of < 1% normal)

          -  Treated or exposed to FVIII concentrates or cryoprecipitate for at least 150 exposure
             days

          -  ≥12 bleeding episodes if receiving on-demand therapy over the preceding 12 months

          -  Agree to use double barrier contraceptive until at least 3 consecutive semen samples
             are negative for AAV 2/6 after SB-525 infusion

        Exclusion Criteria:

          -  Presence of neutralizing antibodies

          -  Current inhibitor, or history of FVIII inhibitor (except for transient low titer
             inhibitor detected in childhood)

          -  History of hypersensitivity response to FVIII

          -  History of Hepatitis B or HIV-1/2 infection

          -  History of Hepatitis C, unless viral assays in two samples, collected at least 6
             months apart, are negative

          -  Evidence of any bleeding disorder in addition to hemophilia A

          -  Markers of hepatic inflammation or overt or occult cirrhosis

          -  History of chronic renal disease or creatinine ≥ 1.5 mg/dL

          -  Presence of liver mass on magnetic resonance imaging (MRI), or, positive alpha
             fetoprotein

          -  Presence of > grade 2 liver fibrosis on elastography for subjects with history of
             treated Hepatitis C or suspicion of chronic liver disease
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: the Effect of HCG Treatment as a Cardiovascular Disease Morbidity Factor in Sjogren Syndrome Patients (NCT02381587)

Eligibility criteria:
Inclusion Criteria:

          1. 18 years old

          2. Both sexes

          3. Patients that diagnosis in sjogren in treated in Meir Medical center in the years
             2003-2014 And treated in Hydroxychloroquine at least a month.

        Exclusion Criteria:

          1. Minors and special populations

          2. Patients that treated in Hydroxychloroquine at less than a month.

          3. Patient that participate in clinical trial and treat with investigational product
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Contradiction
Clinical trial: Can Ideal Mesh Size be Standardized in Open Inguinal Hernia Repair (NCT04280094)

Eligibility criteria:
Inclusion Criteria:

          -  Male patients over 18 years of age who applied for inguinal hernia surgery

        Exclusion Criteria:

          -  Patients under the age of 18

          -  Complicated hernias

          -  Recurrent hernias

          -  Those undergoing laparoscopic hernia repair
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Vital Sign Comparison Between Lifelight and Standard of Care - Development (NCT04003662)

Eligibility criteria:
Inclusion Criteria:

          -  I1. Sufficiently conversant in the English language to satisfy I3.

          -  I2. Able and willing to comply with all study requirements.

          -  I3. Able and willing to provide written informed consent to participate (including by
             parent or legal guardian if under 16 years old).

        Exclusion Criteria:

          -  There are no exclusion criteria.
No condition on gender to be admitted to the trial.

Subject must be at least 3 Years old.


Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? Entailment
Clinical trial: MTZ Plus AMX in the Treatment of Smokers and Non-smokers (NCT01837199)

Eligibility criteria:
Inclusion Criteria:

          -  Chronic periodontitis (AAP 1999);

          -  ≥35 years of age;

          -  Presence of at least 15 teeth;

          -  Minimum of 6 teeth with at least one site each with PD and clinical attachment level
             (CAL) ≥5 mm;

          -  At least 30% of the sites with PD and CAL ≥4 mm and bleeding on probing (BOP).

          -  Smokers: had smoked at least 10 cigarettes per day for a minimum of 5 years;

          -  Non-smokers: had never smoked.

        Exclusion Criteria:

          -  Previous subgingival periodontal therapy;

          -  Pregnancy;

          -  Nursing;

          -  Systemic diseases that could affect the progression of periodontal disease (e.g.
             diabetes, osteoporosis);

          -  Long-term administration of anti - inflammatory medications;

          -  Need for antibiotic pre-medication for routine dental therapy;

          -  Continuous use of mouthrinses containing antimicrobials;

          -  Antibiotic therapy in the previous 6 months

          -  Allergy to MTZ or AMX.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Testis Needle Aspiration of Sperm in Men With Azoospermia (NCT02418832)

Eligibility criteria:
Inclusion Criteria:

          -  Men with Obstructive/Non-Obstructive Azoospermia who turned to sperm cell aspiration
             for IVF and were found suitable for TEFNA and signed consent form.

        Exclusion Criteria:

          -  healthy, non-azoospermic men

          -  men who are unsuitable for the TEFNA procedure

          -  men who don't sign the Informed Consent
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Glucosamine as a Novel Adjunctive Therapy in Oral Lichen Planus (NCT02858297)

Eligibility criteria:
Inclusion Criteria:

          -  Clinically and Histologically proven painful Bullous/erosive or atrophic forms of OLP

        Exclusion Criteria:

          -  lichenoid lesions

          -  Presence of systemic conditions

          -  Smoking

          -  Known hypersensitivity or severe adverse effects to the treatment drugs or to any
             ingredient of their preparation

          -  Pregnancy or breast-feeding

          -  History of previous treatments potentially effective on OLP in last 3 months

          -  Loss of pliability or flexibility in the tissues involved by the oral lesions of
             lichen planus
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: EndogenousTestosterone Response to a Testosterone Boosting Supplement (NCT02600650)

Eligibility criteria:
Inclusion Criteria:

          -  Adult male aged 20 to 40 years.

          -  Fluent in English.

        Exclusion Criteria:

          -  Currently receiving hormonal therapy or testosterone boosting supplement.

          -  Has received hormonal therapy or testosterone boosting supplement within 3 months
             prior to study.

          -  Has experienced adverse event following previous exposure to testosterone boosting
             supplements.
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparison Between Steroid and Different Sites of Botulinum Toxin Injection in the Treatment of Lateral Epicondylalgia (NCT02767635)

Eligibility criteria:
Inclusion Criteria:

          -  spontaneous local pain over lateral epicondyle of the affected elbow for more than six
             months and failure to respond to previous physical therapy or oral medications,

          -  local tenderness around the lateral epicondyle, and

          -  pain elicited or aggravated by resisted contraction of the wrist or middle finger
             extensors.

        Exclusion Criteria:

          -  local steroid injection within the past six months,

          -  coexisting elbow arthritis or arthralgia,

          -  previous trauma or surgery history over the lateral epicondyle,

          -  pregnancy or lactation, and

          -  other systemic, neuromuscular or bleeding disorders that are contraindicated to Botox
             injection.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction