araag2/NLI4PR huggingface dataset:
Clinical trial: Effects of Serotonin Agonist Citalopram on Multimodal Esophageal Stimulation in Healthy Volunteers (NCT04355455)

Eligibility criteria:
Inclusion Criteria:

          -  HV aged between 18 - 60 years

        Exclusion Criteria:

          -  history of psychiatric disease or a positive first degree psychiatric family history

          -  pregnancy or lactation

          -  concomitant administration of any centrally activating medication (anti-depressive
             medication, hypnotics, sedatives, anxiolytics, …)

          -  medication affecting esophageal motility

          -  significant co-morbidities (neuromuscular, psychiatric, cardiovascular, pulmonary,
             endocrine, autoimmune, renal and hepatic)

          -  prior history of esophageal, gastric surgery or endoscopic anti-reflux procedure

          -  history of gastrointestinal disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia (NCT02008799)

Eligibility criteria:
Inclusion Criteria:

        - Azoospermia

        Exclusion Criteria:

        - Absent or surgical removed testes
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Joint Loading vs Normal Physiotherapy Care in Degenerative Knees (V1) (NCT02454374)

Eligibility criteria:
Inclusion Criteria:

          1. Patients referred to the Leeds Community Healthcare Musculoskeletal service aged 45
             years or over with primary symptoms suggestive of degenerative intraarticular knee
             pain with a dominant mechanical presentation (i.e. activity related pain, functional
             limitation, morning stiffness not exceeding 30 minutes) AND

          2. Limitation in weightbearing range of motion of the knee joint (tibiofemoral joint
             limitation in flexion or extension)

        Exclusion Criteria:

          1. Subjects with cognitive impairment or medical conditions preventing understanding or
             participation in the study

          2. Subjects with symptoms requiring surgical evaluation or other intervention

          3. Knee symptoms related to pathology other than degenerative intraarticular pathology

          4. Subjects who are contraindicated from kneeling or crouching

          5. Subjects unable to attend the full study programme
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Extension Study to Evaluate the Safety of Long-Term Use of Relacorilant in Patients With Cushing Syndrome (NCT03604198)

Eligibility criteria:
Inclusion Criteria:

          -  Major Inclusion Criteria:

               -  Have completed a Corcept-sponsored study of relacorilant in endogenous Cushing
                  syndrome with at least 80% compliance with the dosing schedule.

               -  According to the Investigator's opinion will benefit from continuing treatment
                  with relacorilant

        Exclusion Criteria:

          -  Major Exclusion Criteria:

               -  Premature discontinuation from a relacorilant parent study.

               -  Has uncontrolled, clinically significant hypothyroidism or hyperthyroidism

               -  Has poorly controlled hypertension

               -  Has Stage ≥ 4 renal failure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Contradiction
Clinical trial: GnRH Agonist for Dual Trigger in IVF and for Luteal Phase Support in FET (NCT04064840)

Eligibility criteria:
IVF

        Inclusion criteria:

        - Women aged <43 years at the time of IVF treatment

        Exclusion criteria:

          -  Preimplantation genetic diagnosis treatment

          -  Use of donor oocytes or donor embryos

          -  Hydrosalpinx shown on pelvic scanning and not surgically treated

          -  Women at risk of OHSS

        FET

        Inclusion criteria:

          -  Women aged <43 years at the time of IVF treatment

          -  Replacing early cleavage embryos or blastocysts after thawing

          -  FET in natural cycles

        Exclusion criteria:

          -  Frozen early cleavage embryos thawed and cultured to blastocysts prior to transfer as
             requested by the patient

          -  Preimplantation genetic diagnosis treatment

          -  Use of donor oocytes or donor embryos

          -  Hydrosalpinx shown on pelvic scanning and not surgically treated
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 42 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Role of the Robotic Platform in Inguinal Hernia Repair Surgery (NCT02816658)

Eligibility criteria:
Inclusion Criteria:

          1. 21 years or older

          2. No prior open abdominal surgery at or below the umbilicus

          3. Primary or recurrent unilateral inguinal hernia repair

          4. No previous preperitoneal mesh placement

          5. BMI less than or equal to 40kg/m2

        Exclusion Criteria:

          1. Need for an open inguinal hernia repair

          2. Patients presenting for evaluation of bilateral inguinal hernias

          3. Patients requiring surgical repair of a strangulated inguinal hernia

          4. Patients with liver disease defined by the presence of ascites

          5. Patients with end-stage renal disease requiring dialysis

          6. Patients who are unable to give informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Intra and Inter Reliability of 30 Seconds Chair Stand Test as Self-test for Patients With Knee Osteoarthritis. (NCT03855813)

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with knee osteoarthritis. The patients should have most problem
             with their knees, but are allowed to have osteoarthritis in other lower extremity
             joints.

          -  Independent in walking, with or without walking aids.

          -  Understand test instructions verbally and in writing.

        Exclusion Criteria:

          -  Neurological disorders that affects the patients balance or gait.

          -  Severe somatic or mental illness that affect the physical functional performance or
             the ability to understand test instructions verbally or in text.

          -  Knee or hip replacement the past six months.

          -  Other knee surgery the past six months that could affect the physical functional
             performance.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: rhGH Therapy on Hepatic Drug Metabolism (NCT00458991)

Eligibility criteria:
Inclusion Criteria:

          -  Children ages 4 to 14 years with a height less than the 5th percentile for age and sex
             or having a decelerated across two major percentiles (5th, 10th, 25th, 50th, 90th, and
             95th) on standard pediatric growth curves, poor growth velocity (less than 5
             centimeters/year), radiographic evidence of delayed bone age (i.e. greater than 1 SD
             below the mean for chronological age) and a documented diagnosis of idiopathic growth
             hormone deficiency [as determined by failure to raise serum GH concentrations 10
             microgram/Liter following provocative testing with two growth hormone
             secretagogues(e.g. insulin, arginine, or clonidine)].

          -  All subjects will be prepubertal, as determined by Tanner staging.

        Exclusion Criteria:

          -  Children receiving medications known to induce or inhibit hepatic CYP1A2, NAT-2, XO,
             CYP2D6 or CYP3A4 activity.

          -  Subjects with a history of smoking (including exposure to second hand smoke > 8 hours
             per day) or illicit drug use.

          -  Subjects with a history of hepatic, renal, cardiac or thyroid disorders. Presence of
             hepatic, renal, cardiac or thyroid disease will be established based on clinical
             history and results of recent laboratory tests conducted as part of the routine
             medical evaluation of children who are being considered for rhGH therapy.

          -  Children experiencing fever or acute viral illness

          -  Children who have a history of a hypersensitivity reaction to dextromethorphan or
             caffeine

          -  Children who have received prior treatment with rhGH

          -  Children who are receiving corticosteroids or thyroid hormone
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 14 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effectiveness of Pretreatment Letrozole Versus Misoprostol Alone in Missed Abortion (NCT04194658)

Eligibility criteria:
Inclusion Criteria:

          -  Singleton pregnancy.

          -  Primigravida or multigravida.

          -  Gestational age ≤ 20 weeks.

          -  Missed abortion.

        Exclusion Criteria:

          -  Maternal age < 18 years.

          -  Twin pregnancy.

          -  Previous cesarean section.

          -  Allergy to letrozole or misoprostol.

          -  Liver cirrhosis or severe liver impairment.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Entailment
Clinical trial: Knee Osteoarthritis Treatment With Adipose-derived Stem Cells: Phase II Clinical Trial (NCT03308006)

Eligibility criteria:
Inclusion Criteria:

          -  age between 45 and 65.

          -  Participants having Knee osteoarthritis grade 2 or higher "Kellgren and Lawrence
             scale"

          -  Participants had an average pain intensity of grade 4 or more on a 10-point visual
             analog for at least one year.

        Exclusion Criteria:

          -  Patient with history of rheumatic or chronic inflammatory diseases

          -  Patient poorly controlled diabetes,

          -  Patient who currently on OA treatment such as corticosteroids, chondroitin sulfate,
             glucosamine or hyaluronic acid.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment