araag2/NLI4PR huggingface dataset:
Clinical trial: Pilot Study for Imaging of the Esophagus Using a Tethered Capsule OCT Endomicroscopy in the Primary Care Setting (NCT02445027)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects must be scheduled for non-urgent appointment at primary care practice
             including annual wellness visits and routine follow-up appointments.

          -  Subjects must be over the age of 18

          -  Subjects must be able to give informed consent

          -  Subjects must have no solid food for 4 hours prior to the procedure, and only clear
             liquids for 2 hours prior to the procedure.

        Exclusion Criteria:

          -  Subjects with current symptoms of dysphagia

          -  Subjects with any history of intestinal strictures, prior GI surgery, or history of
             intestinal Crohn's disease.

          -  Subjects with current symptoms of fever, nausea or sore throat at the time of the
             appointment.

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Clinical Trial to Evaluate the Efficacy and Safety of Testosterone Gel in Adult Hypogonadal Males (NCT02149264)

Eligibility criteria:
Inclusion Criteria:

          -  Males between 18-75 years of age

          -  Two fasting serum testosterone levels <300 ng/dL

        Exclusion Criteria:

          -  Previous use of the study drug

          -  History of prostate or breast cancer

          -  Prostate-Specific Antigen (PSA) ≥3 ng/mL

          -  Subject is sexually active and not willing to use adequate contraception
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: An Examination of the Value of Shortwave Diathermy and Hydrotherapy for Patients With Osteoarthritis of Their Knees (NCT00726492)

Eligibility criteria:
Inclusion Criteria:

          -  Patients had to have a documented diagnosis of osteoarthritis of their knees.

          -  Patients had to be between 50 and 70 years inclusive.

          -  Patients had to have X-ray evidence of osteoarthritis of their knees.

        Exclusion Criteria:

          -  Patients with another rheumatological condition other than osteoarthritis.

          -  Patients who were unable to understand the concepts, assessment and treatment
             involved.

          -  Patients who had received a cortisone injection into the knee in the previous 30 days.

          -  Patients for whom CSWD or hydrotherapy has been contraindicated.

          -  Patients who have had either CSWD or hydrotherapy in the past.

          -  Patients who had undergone a surgical procedure on either lower limb in the past 6
             months.

          -  Patients who were receiving other physiotherapy treatment.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study to Test the Effect of MK0217A on Vitamin D Inadequacy in Postmenopausal Women With Osteoporosis (0217A-262) (NCT00692913)

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  65 years or older

          -  Diagnosed with osteoporosis (Bone Mineral Density (BMD) T-score <= -2.5 at spine or
             hip) or prior fragility fracture BMD T-score <=-1.5 in at least one of the anatomic
             sites including lumbar spine, total hip, and femoral neck sites

          -  Postmenopausal

          -  Low levels of vitamin D as measured 25-hydroxyvitamin D

          -  Has fallen at least once within the past 12 months

        Exclusion Criteria:

          -  Unable to stand or sit upright for at least 30 minutes

          -  Has a bone disorder other than osteoporosis

          -  Contraindication to the use of FOSAVANCE
Female
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Demodex Density, Immune Response and Oxidative Stress in Rosacea Patients (NCT02556827)

Eligibility criteria:
Inclusion Criteria:

          -  Between the ages of 18-70

          -  No systemic illness

          -  No other inflammatory dermatoses except for rosacea

          -  No smoking

          -  Not using any topical, systemic treatment and sunblock at least a month for rosacea or
             other condition

        Exclusion Criteria:

          -  Systemic illness

          -  Other inflammatory dermatoses except for rosacea

          -  Smoking

          -  Using any topical, systemic treatment and sunblock for rosacea or other condition

          -  Type 4 rosacea patient (only ocular involvement)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Treatment of Benign Uterine Disorders Using High Intensity Focused Ultrasound (MR-HIFU) (NCT02914704)

Eligibility criteria:
Inclusion Criteria:

          -  BMI < 35

          -  Premenopausal

          -  Uterine size <20 gw

          -  Willingness to participate to the research

          -  Uterine fibroids with typical symptoms

          -  Maximum of 4 treated fibroids

          -  Dominant fibroid >2.5cm

          -  >50% of the fibroid is treatable

        Exclusion criteria

          -  Unspecified pelvic tumours or ovarian masses, PID

          -  Major corrective surgery to uterus (simple myomectomy excluded)

          -  Major uterine anomalies

          -  Unability to calculate the volume of uterine fibroids

          -  Marked uterine calcification

          -  Marked scarring of the lower abdomen

          -  Suspicion of malignancy

          -  Marked general health problem contraindicating MRI

          -  Claustrophobia
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Physiology, Imaging and Modeling of Essential Tremor (NCT03811405)

Eligibility criteria:
Inclusion Criteria:

          -  Existing unilateral or bilateral VIN DBS for ET, non-demented (MMSE>24), and must have
             a documented suboptimal tremor suppression on two successive visits (compared to the
             baseline post-operative improvement at 6 months following ET DBS surgery). For
             bilateral cases, the most affected tremor side will be studied.

        Exclusion Criteria:

          -  No diagnosis of Essential Tremor
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Translation of the Sydney Swallow Questionnaire and Validation of the German Version (NCT01965964)

Eligibility criteria:
Inclusion criteria: - patients with diagnosed dysphagia "of any causes"

          -  sufficient proficiency in german

          -  voluntary participation

        Exclusion criteria: - insufficient knowledge of the german language

          -  cognitive limitations

          -  reduced general state of health
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: ADX10059 as an add-on Therapy to Proton Pump Inhibitors (PPIs) in Patients With Gastroesophageal Reflux (GERD) (NCT00810485)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of typical GERD

          -  partial responder to a stable standard clinical symptoms control dose of PPI therapy

          -  body mass index ≤ 32 kg/m2

        Exclusion Criteria:

          -  exclusively atypical symptoms of GERD

          -  symptoms that have been shown not to be associated with GERD

          -  erosive oesophagitis

          -  treated with a dose of PPI greater than the dose indicated for clinical symptom
             control of GERD

          -  hiatus hernia > 3 cm

          -  current diagnosis of co-existing psychiatric disease

          -  known clinical significant allergy or known hypersensitivity to drugs

          -  is pregnant or breast-feeding

          -  has received sodium valproate or topiramate within 30 days of Screening

          -  has a history of a significant medical condition that may affect the safety of the
             patient or preclude adequate participation in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Bright Light on Sex Hormones and Ovulation in Humans (NCT00327366)

Eligibility criteria:
Inclusion Criteria:

          -  Age 19-40 years

          -  Mean menstrual cycle 28-38 days

          -  Good general health

          -  Generally normal sleep-wake regimen

          -  Motivated for free participation

        Exclusion Criteria:

          -  Low cooperation

          -  Medications known to interfere with hormone release

          -  Clinically evident endocrine abnormalities including the signs of

          -  Hyperandrogenism

          -  Travel over several time zones during two months prior the study
Female
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction