araag2/NLI4PR huggingface dataset:
Clinical trial: Is Adding E2 to P4 Luteal Support In High Responder Long Gn-RH Agonist ICSI Cycles Detrimental to Outcome? RCT (NCT01790282)

Eligibility criteria:
Inclusion criteria

          -  age<40 years,

          -  first ICSI cycle,

          -  third day FSH< 10 mIU/mL,

          -  serum E2 level on day of hCG administration <4,000 pg/mL,

          -  number of ova obtained >15

        Exclusion Criteria:

          -  age 40 years or more,

          -  basal FSH 10 mIU/mL or more ,

          -  eggs retrieved 15 or less ,

          -  E2 level on day of hCG administration 4000 or more pg/ mL or more,

          -  repeat ICSI , need for PGD, presence of myoma , hydrosalpinx (unless disconnected)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Investigating a Von Willebrand Factor (VWF) Functional Screening Assay for Assigning the Phenotypic Variants of Von Willebrand Disease (VWD) (NCT02466789)

Eligibility criteria:
Inclusion Criteria:

          -  New subjects undergoing evaluation for the diagnosis of VWD determined to have a
             VWF:Ag or VWF: RCo < 50 IU/dl and or a VWF:RCo/VWF:Ag of <0.7. Also subjects will be
             included if Type 2 N VWD is clinically suspected

        Exclusion Criteria:

          -  Those subjects whose lab results do not meet the inclusion criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Mirena or Conventional Medical Treatment for Menorrhagia (NCT00864136)

Eligibility criteria:
Inclusion Criteria:

          -  Women between the ages of 18-45 (inclusive) not intending to get pregnant during the
             next year

          -  Women complaining of heavy menstrual bleeding over several consecutive cycles

          -  Women without structural or histological abnormality of the uterus, or with fibroids
             less than 3 cm in diameter which are causing no distortion of the uterine cavity
             (eligible for pharmaceutical treatment according to the NICE guideline 2007)

          -  Informed consent (where required by laws or regulations)

        Exclusion Criteria:

          -  The contraindications and warnings of the respective Summary of Product
             Characteristics (Mirena, combined oral contraceptives, oral/injectable progestogens,
             non-steroidal anti-inflammatory drug, or anti-fibrinolytic agent) must be followed.

          -  Women taking hormone replacement therapy

          -  Women with symptoms such as intermenstrual or post-coital bleeding, unless an
             endometrial biopsy has been performed and pathology excluded

          -  Women with fibroids that are palpable abdominally or who have intra-cavity fibroids
             and/or whose uterine length as measured at ultrasound or hysteroscopy is greater than
             12 cm (NICE guideline 2007)

          -  Women on anticoagulative therapy or other treatment (including e.g. Copper IUD use)
             known to cause menorrhagia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Entailment
Clinical trial: Non-invasive Imaging of Muscle Structure in Duchenne Muscular Dystrophy Using Multispectral Optoacoustic Tomography (NCT03490214)

Eligibility criteria:
DMD-Patients

        Inclusion Criteria:

          -  Histologic or genetically proven DMD

          -  Age 3-10 years

        Exclusion Criteria:

        -

        Healthy controls

        Inclusion Criteria:

          -  Male

          -  Age 3-10 years

        Exclusion Criteria:

          -  Suspected muscular disease/myopathia

          -  missing informed consent
Male
Accepts Healthy Volunteers
Subject must be at least 3 Years old.
Subject must be at most 10 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: A One Year Open Label Study for the Treatment of Hypogonadism (Low Testosterone) in Men Who Have Completed ZA-203 (NCT01386567)

Eligibility criteria:
Inclusion Criteria:

          -  Successful completion of ZA-203

          -  Ability to understand and provide written informed consent

          -  Agreement to use a condom, and with a fertile female partner, another form of
             contraception

          -  Agreement to provide semen samples in the clinic

        Exclusion Criteria:

          -  Any condition which, in the opinion of the Investigator, would make the Subject an
             unsuitable candidate for enrollment in the study
Male
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of Meloxicam Capsules to Treat Osteoarthritis Pain (NCT01787188)

Eligibility criteria:
Inclusion Criteria:

          -  Primary diagnosis of Functional Class I-III OA of the hip or knee

          -  Chronic user of nonsteroidal anti-inflammatory drugs (NDAIDs) and/or acetaminophen for
             OA pain

          -  Discontinued all analgesic therapy at Screening

          -  For women of child-bearing potential: a woman who is not pregnant and not nursing, and
             who is practicing an acceptable method of birth control

        Exclusion Criteria:

          -  History of allergic reaction or clinically significant intolerance to acetaminophen,
             aspirin, or any NSAIDs, including meloxicam

          -  Requires continuous use of opioid or opioid combination products to control OA pain of
             the knee or hip

          -  Clinically significant unstable cardiac, respiratory, neurological, immunological,
             hematological, or renal disease

          -  Significant difficulties swallowing capsules or unable to tolerate oral medication

          -  Previous participation in another clinical study of Meloxicam Capsules or received any
             investigational drug or device or investigational therapy within 30 days before
             Screening
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Long-Term Results of DDD Pacing in Obstructive Hypertrophic Cardiomyopathy (NCT00001530)

Eligibility criteria:
Group 1:

        HCM patients, aged grater than 20 years of either gender who received DDD pacemakers at the
        NIH at least 4 years ago, for relief of LVOT obstruction and drug-refractory symptoms.

        Group 2:

        HCM patients selected from Group 1 who at the follow-up cardiac catheterization are
        demonstrated to have either (1) no significant LVOT obstruction (less than 30mm HG at rest
        and less than 50mm HG with Isuprel); or (2) a substantial reduction of the LVOT obstruction
        (greater than 50% reduction in LVOT gradient).

        Patient who have developed a heart block will be excluded from group 2.

        Females must have a negative pregnancy test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: Cryotherapy Associated With Exercise in Pain Control and Physical Function in Individuals With Knee Osteoarthritis (NCT03360500)

Eligibility criteria:
Main Inclusion Criteria:

          -  Diagnosed with knee osteoarthritis based on clinical and radiographic criteria of
             American College of Rheumatology

          -  Grade 2 or 3 according to the criteria of Kellgren & Lawrence knee osteoarthritis
             radiographic examination scale.

          -  Minimum score of 4 cm in Visual Analogue Scale (total 10 cm)

          -  Medical prescription, showing that the participant is capable of performing physical
             activities

        Main exclusion Criteria:

          -  Physical therapy within 3 months prior to the research project

          -  Corticosteroid injection in the knee (in the previous 6 months)

          -  Medical condition (cardiorespiratory, neurological and / or musculoskeletal)

          -  Previous ankle, knee or hip surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Lansoprazole for Subgroups of Functional Dyspepsia (NCT01040455)

Eligibility criteria:
Inclusion Criteria:

          -  Dyspeptic adult outpatients

          -  Characteristic dyspeptic symptoms according to Rome III criteria (bothersome
             postprandial fullness, early satiation, epigastric pain, or epigastric burning)

          -  Upper gastrointestinal endoscopy excluding structural diseases

        Exclusion Criteria:

          -  aged less than 20 years old,

          -  organic lesions such as peptic ulcer, tumor of any kind, stricture or structural
             deformity, erosive esophagitis, or vasculopathy on endoscopy

          -  typical and predominant reflux symptoms (heartburn or acid regurgitation)

          -  comorbidity with malignancy, diabetes mellitus, liver cirrhosis, renal failure, or
             porphyria

          -  history of intra-abdominal surgery

          -  concurrent use of aspirin, non-steroidal anti-inflammatory drug or proton pump
             inhibitor

          -  history of allergy or severe side effects to lansoprazole

          -  pregnant or lactating women.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Relief From Side Effects: Clinical Use of Electrodes With Direction (NCT03795935)

Eligibility criteria:
Inclusion Criteria:

          -  Participants must have been implanted with the DBS

          -  Participants must have been diagnosed with Essential Tremor

          -  Participants must experience negative side effects from their DBS which limit control
             over their tremor

          -  Participants must be able to receive benefit from their stimulator, but at the cost of
             negative side effects

        Exclusion Criteria:

          -  All individuals who meet criteria outlined in "inclusion criteria" may be eligible for
             this study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Contradiction