araag2/NLI4PR huggingface dataset:
Clinical trial: This is a Study to Get More Information About Non Ambulatory Boys & Men With Duchenne Muscular Dystrophy (NCT01098708)

Eligibility criteria:
Inclusion Criteria:

          1. For Non-ambulatory study, boys must be unable to walk without assistive devices for
             greater than or equal to one year.

          2. Age at onset of study for non-ambulatory boys and men: greater than or equal to 7
             years through age 22 years.

          3. Genetic or biopsy confirmation of dystrophinopathy or clinical diagnosis of DMD with
             biopsy/genetic confirmation in a primary relative.

        Exclusion Criteria:

        1. For Non-ambulatory study, the inability to understand and cooperate with the testing
        would exclude a subject. -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 22 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Demographics and Findings of Upper Endoscopy Patients (NCT00576992)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who present to the KCVA GI endoscopy unit with symptoms of reflux,upper
             abdominal pain, anemia (patients referred by their primary care physicians with a
             diagnosis of low hemoglobin (< 10 G/DL, and or dyspepsia

        Exclusion Criteria:

          -  Weight loss (Weight loss of > 10% of their mean body weight over last 6 months)

          -  Dysphagia

          -  Gastrointestinal bleeding

          -  Gastrointestinal malignancy

          -  Recent EGD (in the past 5 years)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Diagnosis and Mechanism of Pleural Effusion (NCT03997669)

Eligibility criteria:
Inclusion Criteria:

        Patients with pleural effusion, who has not been treated

        Exclusion Criteria:

        Patients with pleural effusion, who has already been treated
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: A Phase 2/ 3 Trial to Evaluate the Efficacy and Safety of BAY86-6150 (NCT01625390)

Eligibility criteria:
Inclusion Criteria:

          -  Male subjects

          -  12 to 62 years-of-age

          -  History of moderate or severe congenital hemophilia A or B with inhibitors to FVIII or
             FIX

          -  4 or more bleeding episodes in the last 6 months before enrollment.

        Exclusion Criteria:

          -  Clinically relevant coagulation disorder other than congenital hemophilia A or B with
             inhibitors

          -  History of coronary and/or peripheral atherosclerotic disease

          -  Disseminated intravascular coagulopathy, or stage 2 hypertension

          -  Angina pectoris

          -  Myocardial infarction

          -  Transient ischemic attack

          -  Stroke

          -  Congestive heart failure

          -  Thromboembolic event
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 62 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluating Different Modalities for Pleural Adhesiolysis at Assuit University Hospital (NCT03172052)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with symptomatic pleural effusion in whom the symptoms excepted to be
             relieved by pleural fluid drainage.

          -  Presence of intrapleural adhesions as documented sonographically.

          -  Difficult thoracentesis.

          -  Failure of satisfactory pleural fluid drainage 24 hours following intercostal tube
             (ICT) placement provided that the tube was properly positioned and not obstructed.

          -  Written consent, free and informed.

        Exclusion Criteria: patients have contraindications for any of our procedures will be
        excluded.

          -  Contraindications for streptokinase instillation i.e. (Previous allergic reaction,
             bronchopleural fistula, trauma or surgery within 48 hrs, history of hemorrhagic
             stroke, coagulation defects and previous streptokinase thrombolysis).

          -  Patients who are unfit for general anaesthesia.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Somatropin Treatment to Final Height in Turner Syndrome (NCT00191113)

Eligibility criteria:
Inclusion Criteria:

          -  girl with Turner syndrome

          -  prepubertal, Tanner stage I breast

          -  height velocity less than 6 cm/year and height less than or equal to the tenth
             percentile for sex and age in general population

          -  at least 6 months (preferably 12 months) of accurate height measurements available for
             calculation of pre-study height velocity

          -  if thyroxine deficient, to have received replacement therapy, and for six months prior
             to enrollment have had normal thyroid function tests

        Exclusion Criteria:

          -  prior treatment with growth hormone

          -  presence of a Y component in karyotype with gonads in situ

          -  diabetes mellitus
Female
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 13 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery (NCT00245375)

Eligibility criteria:
Inclusion Criteria:

        Patients may take part in this study if the answer is YES to all of these questions:

          -  Female or male between 17-65 years of age

          -  Going to have one of the following surgeries:

               -  umbilical hernia repair

               -  inguinal hernia repair

               -  small incisional or abdominal wall hernia repair

               -  laparoscopic cholecystectomy (gallbladder removed)

          -  Going home after their surgery the same day

          -  Have signed consent form.

        Exclusion Criteria:

        Patients have had or have:

          -  Been diagnosed with peptic ulcer disease or bleeding stomach ulcer in the recent past
             and are not currently on a proton pump inhibitor (special antacid medication, eg.
             Losec®, Pantoloc®, Prevacid®, Nexium®).

          -  Suffered from asthma

          -  Allergies to codeine, non-steroidal anti-inflammatory drugs (Advil®, Ibuprofen),
             aspirin, or acetaminophen

          -  Been taking other prescription pain medications prior to their surgery

          -  A history of chronic pain disorder

          -  Fibromyalgia (a chronic pain illness with symptoms of muscle aches, pain, stiffness,
             general fatigue and sleep problems)

          -  Active kidney disease or failure

          -  Known liver disease

          -  Are females who are pregnant or nursing

          -  A problem with alcohol or drug abuse.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 17 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Internet Auditory Rehabilitation: Follow-up to Adult Hearing Screening (NCT04122183)

Eligibility criteria:
Inclusion Criteria:

          -  Subject must fail a hearing screening (any threshold >34 decibels hearing level at
             2000 or 3000 Hertz in either ear) or show equivalent or greater degree of hearing loss
             on most recent audiogram.

          -  Free of obvious outer or middle ear disease (as measured by otoscopy)

          -  Between the ages of 45 and 85

          -  Pass a health literacy screening

          -  Pass a thinking skills screening

        Exclusion Criteria:

          -  Experience seeing an audiologist for a hearing evaluation or management

          -  Experience using a hearing aid
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction
Clinical trial: Strontium Ranelate and KOA (NCT03937518)

Eligibility criteria:
Inclusion Criteria:

        Patients aged ≥ 40 years with symptoms of knee osteoarthritis

        Exclusion Criteria:

        rheumatoid arthritis, spondyloarthropathy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 62 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients (NCT03127267)

Eligibility criteria:
Main inclusion criteria include:

          -  Patients diagnosed with laboratory supported probable, clinically probable or definite
             ALS according to the World Federation of Neurology Revised El Escorial criteria

          -  Patient with a familial or sporadic ALS

          -  ALS disease duration from diagnosis no longer than 24 months at the screening visit

          -  Patient treated with a stable dose of riluzole (100 mg/day) for at least 12 weeks days
             prior to the baseline visit

          -  Patient with an ALSFRS-R score progression between onset of the disease and screening
             of > 0.3 per month, confirmed with an ALSFRS-R score progression of ≥ 1 point during a
             12-week run-in period between screening and randomization.

          -  Patient with a score, at screening, of at least 26 overall, including a score of at
             least 3 on item #3 and at least 2 on each of the 12 ALSFRS-R individual component
             items and with a score, at randomization, of at least 2 on each of the 12 ALSFRS-R
             individual component items

        Main exclusion criteria include:

          -  Patient with dementia or significant neurological, psychiatric, systemic or organic
             disease, uncontrolled or that may interfere with the conduct of the trial or its
             results

          -  Patient with a FVC < 60% predicted normal value for gender, height, and age at
             screening and baseline

          -  Pregnant, or nursing female patient
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 81 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment