araag2/NLI4PR huggingface dataset:
Clinical trial: Early Biomarkers for ARthritic PAIN to Guide Improved Treatments for Arthritis (NCT03533569)

Eligibility criteria:
Inclusion Criteria:

        Inclusion Criteria for OA patients:

          -  Fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of
             knee osteoarthritis

          -  Symptomatic knee pain

          -  On usual care for knee osteoarthritis including paracetamol and/or NSAIDs

        Inclusion criteria for Inflammatory Arthritis Patients:

          -  Fulfilling the American College of Rheumatology (ACR) criteria for the diagnosis of
             inflammatory arthritis i.e. rheumatoid arthritis (Anti-CCP antibodies & Rheumatoid
             Factor checked ), psoriatic arthritis or spondyloarthropathy

          -  Symptomatic knee pain

          -  On usual care for arthritis including disease-modifying anti-rheumatic drugs (DMARDs),
             paracetamol and/or NSAIDs

        Exclusion Criteria:

          -  Other rheumatological diagnosis e.g. systemic lupus erythematosus, fibromyalgia,
             Polymyalgia Rheumatica, Gout, Giant Cell Arteritis, Sjogren's syndrome

          -  History of uncontrolled depression

          -  Recent surgery

          -  Uncontrolled ischaemic heart disease

          -  Uncontrolled diabetes mellitus

          -  Alcohol consumption > 14 units/week as per UK National guidelines

          -  Participants unable to give full informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Lutein for Age-Related Macular Degeneration (NCT00006202)

Eligibility criteria:
INCLUSION CRITERIA:

        Men and women aged 60 years or older.

        Patients ranging from no AMD with little or no drusen in either eye through end stage AMD
        (geographic atrophic, retinal pigment epithelial detachment, or other signs of
        neovascular/exudative disease) in their eye with worst disease will be eligible.

        The ability to understand and sign an informed consent form prior to enrollment.

        EXCLUSION CRITERIA:

        Ocular disease which confounds assessment of the retina other than age-related macular
        degeneration including diabetic retinopathy, central serous choroidopathy, optic atrophy,
        retinal vein occlusion, active uveitis, significant explained or unexplained visual field
        loss, or any other type of retinopathy or retinal degeneration.

        Chronic requirement for any systemic or ocular medication for other diseases such as
        glaucoma.

        Patients has regularly been taking lutein supplements during the last 3 months or is
        currently taking lutein supplements. The daily use of the new Centrum or Centrum Silver or
        other similar multivitamins will be allowed but should be limited to a maximum of twice a
        day.

        Abnormal liver function tests.

        Inability to be followed for a period of 1 year.

        Acute potentially life-threatening illness such as heart attack in the last year, malignant
        cancer or blood disease not in remission.

        History of lung cancer.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient description (patient's own words): I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Does the patient match the trial criteria? Entailment
Clinical trial: NBI for Identifying Resection Margin Status in Gastric Cancer (NCT02926716)

Eligibility criteria:
Inclusion Criteria:

          -  The patient from over 20 to under 90 years

          -  The patient who is diagnosed as gastric cancer clinically by endoscopy or computed
             tomography

          -  The patient who is informed and consent about the purpose and contents of this study
             prior to the participation in this study

        Exclusion Criteria:

          -  The patient who shows far advanced gastric cancer preoperatively or intraoperatively

          -  The patient with previous medical history of other treatment for gastric caner such as
             endoscopic resection, chemotherapy, radiation, immunotherapy, and so on
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Survey in Patients With Chronic Adrenal Insufficiency in Germany (NCT00444119)

Eligibility criteria:
Inclusion Criteria:

          -  age > 18 years

          -  chronic adrenal failure with disease duration > 12 months and hormone replacement
             therapy for cortisol deficiency

        Exclusion Criteria:

          -  adrenal insufficiency due to adrenocortical carcinoma

          -  AI due to long-term pharmacological glucocorticoid treatment

          -  glucocortiocid doses above 7.5 mg prednisolone equivalent for other reasons than AI
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Entailment
Clinical trial: Spectral Domain Optical Coherence Tomography Imaging of the Eyes of Neonates (NCT01404247)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy term, gestational age of 38-42 weeks inclusive.

          -  Able to be transported to the Eye Clinic.

          -  No longer monitored. On no intravenous or other lines.

        Exclusion Criteria:

          -  History of hyperglycemia in the infant (a blood sugar greater than 100mg%, per
             Laboratory Policy on Critical Values for infants less than 20 days old).

          -  Feeding intolerance.

          -  Green-tinged aspirates/emesis.

          -  Abdominal distention.

          -  History of genetic consult indicating any abnormality.

          -  Any known ocular disorder.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 38 Weeks old.
Subject must be at most 42 Weeks

Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy of Green Tea Buccal Tablets in Oral Lichen Planus (NCT03415165)

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic lesions.

          -  OLP lesions with the diagnosis confirmed both clinically and histopathologically.

          -  Clinical score higher than 3.

          -  Disease duration of more than 2 months.

          -  Absence of dysplasia in histological section

        Exclusion Criteria:

          -  Presence of any visible oral lesion other than OLP.

          -  Pregnant or breast-feeding women,

          -  Immuno-deficiency diseases.

          -  Current malignancy or malignancy in history.

          -  Concomitant treatment potentially effective on OLP within the previous 2 months such
             as antimalarial agents, retinoids, corticosteroids or immunosuppressive drugs.

          -  Severe or recurrent infections.

          -  Lichenoid reaction.

          -  Patients presents with skin lesions which may require systemic corticosteroid therapy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 17 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: NSAID Treatment in Knee Osteoarthritis (NCT01860833)

Eligibility criteria:
Inclusion Criteria:

        Patients eligible for the study were:

          -  older than 50 years and

          -  had primary knee OA diagnosed according to the clinical and radiological criteria of
             the American Rheumatism Association.

        Further inclusion criteria were:

          -  clinical signs of joint inflammation (warmth, swelling or effusion) and

          -  a disease severity grade 2 or 3 according to the Kellgren-Lawrence classification

        Exclusion Criteria:

          -  allergy to NSAIDs,

          -  progressive serious medical conditions (such as cancer, AIDS or end-stage renal
             disease),

          -  history of gastrointestinal ulcer or bleeding,

          -  a hemoglobin concentration lower than 11.5 g/dL,

          -  renal diseases (serum creatinine concentration more than 1.2 times the upper limit of
             the normal range according to the central laboratory definition reference values), or

          -  liver dysfunction (serum alanine or aspartate transaminase concentrations more than
             1.5 times the upper limit of normal range according to the central laboratory
             definition reference values).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Short-Term Effects & Safety of an Accelerated Intravenous Iron Regimen in Patients With Heart Failure (NCT01925703)

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  Admission to the general cardiology or heart failure services and under the care of a
             cardiologist at the study institution

          -  New York Heart Association Class II-IV heart failure

          -  Ejection fraction < 40%

          -  Serum hemoglobin < 12.0 g/dL

          -  Ferritin < 100 ng/mL or 100-300 ng/mL with transferrin saturation (TSAT) < 20%

          -  Patients deemed by an attending physician to require intravenous iron therapy based on
             previous attempts to correct iron deficiency or other patient-specific circumstances

        Exclusion Criteria:

          -  Anemia of other known etiology (e.g., malignancy, malabsorption syndromes)

          -  Use of iron or erythropoietin-stimulating agents within previous 12 weeks

          -  Blood transfusion within previous 12 weeks; additionally, if patients receive blood
             transfusions during the study period, they will remain in the safety analysis but will
             be excluded from efficacy analysis

          -  Active bleeding

          -  Known infection at admission

          -  Immunosuppressant therapy

          -  Renal replacement therapy

          -  Known pregnancy

          -  Any other criteria deemed by the attending physician to warrant exclusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Low Dose Continuous Administration of the Progesterone Receptor Modulator VA2914 (NCT00456924)

Eligibility criteria:
Inclusion Criteria:

          -  women in good general health with regular, ovulatory menstrual cycles

          -  age 18-35

          -  not pregnant

          -  not sexually active or reliably use barrier methods of contraception

          -  normal liver and renal functions and normal laboratory exams

        Exclusion Criteria:

          -  pregnant or breastfeeding

          -  oral contraception, IUD or other hormonal treatment

          -  use of agents known to induce hepatic P450

          -  cardiovascular disorder

          -  hepatic, renal, or gastrointestinal disorder

          -  metrorrhagia

          -  abnormal transvaginal ultrasound (at baseline)

          -  history of abnormal endometrial biopsy,

          -  cancer

          -  depression

          -  mental illness

          -  epilepsy

          -  migraines

          -  abnormal Pap Smear requiring further exploratory examination

          -  anovulatory cycle before treatment

          -  extreme overweight or underweight (body mass index < 16 ou >28)

          -  subjects unlikely to comply with the protocol, e.g., uncooperative attitude, inability
             to return for follow-up visits, and unlikelihood of completing the study

          -  use of narcotics

          -  more than 10 cigarettes per day, more than 2 glasses of wine/beer per day

          -  surgical procedures planned in the 6 months following screening visit
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction