araag2/NLI4PR huggingface dataset:
Clinical trial: Effect of Healing Time on New Bone Formation Following Tooth Extraction and Ridge Preservation With Demineralized Freeze-Dried Bone Allograft (NCT02154386)

Eligibility criteria:
Inclusion Criteria:

          -  Patient currently a patient at dental school or eligible for treatment at dental
             school

          -  Patient resides within 50 mile radius of dental school

          -  A single rooted tooth that has been identified by dental faculty as requiring
             extraction

          -  Have adequate restorative space for a dental implant-retained restoration

          -  Have at least 10mm of alveolar bone height, without impinging on the maxillary sinus
             or inferior alveolar canal.

          -  Have a dehiscence of the buccal or lingual bony plate of the tooth socket extending no
             more than 50% of the total depth of the socket.

          -  Female patients who have undergone a hysterectomy, tubal ligation, or menopause, and
             non-pregnant women of child-bearing potential.

        Exclusion Criteria:

          -  not meeting inclusion criteria above

          -  Active localized or systemic infection other than periodontitis.

          -  Inadequate bone dimensions or restorative space dimensions to place a dental implant

          -  Presence of a disease entity, medical condition or therapeutic regimen which decreases
             probability of soft tissue and bony healing, e.g., poorly controlled diabetes,
             chemotherapeutic and immunosuppressive agents, autoimmune diseases, history of
             bisphosphonate use or long-term steroid therapy.

          -  Positive medical history of endocarditis following oral or dental surgery.

          -  Sensitivity or allergy to Bacitracin, Gentamicin, Polymyxin B Sulfate, alcohol and/or
             surfactants (per package insert)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 89 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Liquid Meal Replacements in Conjunction With Lifestyle Intervention in Overweight Adolescents (NCT00207519)

Eligibility criteria:
Inclusion Criteria:

          -  BMI >85th% for age and sex

          -  Weight gain over the last 6 months of >5% than expected on the growth curve

          -  12-17 years of age

        Exclusion Criteria:

          -  Subjects with intolerance to dairy products (e.g., lactose intolerance) will be
             excluded from entering into the study.

          -  Subjects must not have a history of clinically significant cardiac disease, congenital
             heart disease, any clinically significant abnormal cardiac condition, or be known to
             have a clinically significantly abnormal ECG. Specifically excluded conditions include
             coronary artery disease, clinically significant cardiac arrhythmias, and congestive
             heart failure.

          -  Subjects must not have a history of anorexia nervosa, untreated hypothyroidism (TSH
             greater than 4.0 mU/L for a second generation test), malignancy, pathophysiologic or
             genetic syndromes associated with obesity (i.e., Cushing's syndrome, Turner's
             syndrome, Prader Willi syndrome), major psychiatric illness such as bi-polar disorder,
             ADD, major depression, bulimia, schizophrenia, or psychosis.

          -  Subjects may not participate in any weight management program, except for that in this
             study, during this pilot. Subjects may not use prescription or over-the-counter (or
             herbal) weight control medication during the trial.

          -  Subjects must not have a history of alcohol or drug addiction or substance abuse
             within the previous 2 years.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 12 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Italian Validation of the Beaumont Behavioural Inventory (BBI) (NCT04440644)

Eligibility criteria:
Inclusion Criteria:

          -  possible, probable or definite ALS according to El Escorial revised criteria

        Exclusion Criteria:

          -  Any other clinically significant cardiovascular, gastrointestinal, hepatic, renal,
             neurological or psychiatric disorder or any other major concurrent illness that in the
             opinion of the investigator could interfere with the interpretation of the study
             results
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: WiiMote Game Controller as a Device to Study Movement Disorders (NCT00802191)

Eligibility criteria:
Inclusion Criteria:

          1. Men and women, aged 18 or older, with abnormal movements (including tremor, chorea,
             dystonia, myoclonus, and tic) and normal controls (subjects without abnormal
             movements).

          2. Subjects must be willing and able to comply with study procedures.

          3. Patients must be willing and able to give meaningful, written informed consent.

        Exclusion Criteria:

        1. Significant cognitive impairment which, in the opinion of the Investigator, would
        interfere with the ability to complete all the tests required in the protocol.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of Smoking and Vitamin D3 on the Levels of Human Cathelicidin Peptide LL-37 (NCT03923218)

Eligibility criteria:
Inclusion Criteria for chronic periodontitis groups:

          -  Clinical attachment loss ≥ 5mm

          -  Probing depth ≥5mm

          -  Bone loss affecting >30% of the existing teeth on clinical and radiographic
             examination

          -  gingival index (GI) score> 1

        Inclusion criteria for control group:

          -  full-mouth PD was≤ 3mm,

          -  Gingival index <1

          -  there was no indication of Attachment Loss or no radiographic evidence of alveolar
             bone loss in control group.

          -  Non-smokers.

        Smoking criteria for groups:

          -  patients smoked more than 10 cigarettes in a day

          -  smoking for 3 or more years,

        Exclusion Criteria:

          -  systemic condition (diabetes, cardiovascular disease, immunologic disorders,
             hepatitis, e.g.)

          -  pregnancy, lactation or menopause term,

          -  antibiotic treatment or non-steroidal anti-inflammatory medications within the last 3
             months before the study,

          -  non-surgical periodontal treatment during the last 6 months before the study,

          -  treatment with Vitamin D supplementation before the study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Dancing Against Fall Fractures in Osteoporosis Patients and Healthy Elderly (NCT03683849)

Eligibility criteria:
Patient groups

        Inclusion Criteria:

          -  Verified osteoporosis (T-score -2.5 to -3.5) from previous Dual-energy X-ray
             absorptiometry scanning (DXA)

          -  Receiving medical treatment for osteoporosis

        Exclusion Criteria:

          -  Drug addiction defined as the use of cannabis, opioids or other drugs.

          -  Use of medical cannabis.

          -  Previous neurologic, musculoskeletal (besides osteoporosis) or mental illnesses

          -  Lack of ability to cooperate.

          -  Osteoporosis grade higher than moderate or severe (T-score < -3.5)

        Healthy elderly groups

        Inclusion Criteria:

        • T-score higher than -2.5 from previous Dual-energy X-ray absorptiometry scanning (DXA)

        Exclusion Criteria:

          -  Drug addiction defined as the use of cannabis, opioids or other drugs.

          -  Use of medical cannabis.

          -  Previous neurologic, musculoskeletal (besides osteoporosis) or mental illnesses

          -  Lack of ability to cooperate.

          -  Osteoporosis grade higher than mild, moderate or severe (T-score < -2.5)

          -  Receiving medical treatment for osteoporosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes (NCT03500016)

Eligibility criteria:
Inclusion Criteria:

          -  GAD65 antibody negative patients with T2D

          -  Duration of diabetes 6 months to 10 years

          -  No diabetic complications

          -  Treated with either diet alone or diet in combination with either metformin, oral
             DPP-4 inhibitors or sulphonylureas

          -  Patients should be able and willing to discontinue all drugs for 1 weeks prior to the
             studies

          -  Obese and lean controls should be healthy, glucose tolerant and drug naive

          -  Obese and lean controls should have no family history of diabetes

          -  All participants should be able to provide informed written consent

        Exclusion Criteria:

          -  Any unknown disease or need for medication that occurs after inclusion

          -  Abnormal ECG, screening blood tests and/or severe hypertension

          -  Impaired glucose tolerance in non-diabetic subjects
Male
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Prevalence of PE in ED Patients With Isolated Syncope (NCT03487237)

Eligibility criteria:
Inclusion Criteria:

          -  Age >= 18 years visiting the Emergency Department,

          -  history of syncope in the past 24 hours: loss of consciousness, rapid onset, short
             duration (<1 min), transient, with spontaneous and rapid recovery without post event
             confusion

          -  With or without prodromes

          -  Without any other obvious cause

          -  Informed written consent

          -  Affiliation to a social security system (AME Excepted)

        Exclusion Criteria:

        - Other criteria for PE suspicion : Acute onset of dyspnea Acute severe chest pain,

          -  Pregnancy

          -  Concurrent anticoagulation treatment

          -  Other obvious cause of syncope : Seizure, Stroke, Traumatic brain injury , toxic
             intake , Atrioventricular block type 3
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: Cistanche Total Glycosides for Amyotrophic Lateral Sclerosis: A Randomized Control Trial (RCT) Study Assessing Clinical Response (NCT00753571)

Eligibility criteria:
Inclusion Criteria:

          -  All subjects must have a verifiable diagnosis of ALS of 0.5 to 2 years' duration.

          -  The diagnosis must be supported by the Revised Criteria of the World Federation of
             Neurology.

          -  The grades of diagnosis must be clinically definite ALS or clinically probable ALS.

          -  All subjects must be over age 18 and below 65.

          -  The ALS is mildly to moderate based on ALS Health State Scale.

          -  Electrophysiological features show CMAP amplitude of motor nerve normal or mild
             declining.

          -  Serum creatine kinase is normal or mild upper, less than 500U/L.

        Exclusion Criteria:

          -  If anyone of the above eligibility requirements is not met

          -  Use of any other investigational agent within 30 days beginning the treatment phase of
             this study

          -  Severe cardiac, pulmonary, hepatic or/and hematic disease

          -  HIV positivity or signs and symptoms consistent with HIV infection

          -  Pregnant or nursing women

          -  History of cancer with less than 5 years documentation of a disease-free state

          -  History of anaphylactic reaction or hypersensitivity to G-CSF or proteins derived from
             E.coli

          -  Alcohol or drug abuse in recent 1 year

          -  Can't understand or obey the rules of treatment

          -  Blood donor in recent 30 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment