araag2/NLI4PR huggingface dataset:
Clinical trial: Study to Evaluate Dietary Modification in Patients With Functional Dyspepsia. (NCT02863822)

Eligibility criteria:
Inclusion Criteria:

          -  Men and women 18 years and older

          -  Diagnosis of FD with either PDS or EPS as measured by Rome III Criteria

          -  Patients describing inadequate relief of dyspepsia symptoms

          -  Endoscopy performed in the last 3 years and negative for an organic cause for
             dyspeptic symptoms

          -  H pylori negative by non-invasive testing or biopsy. Patients with a history of
             successfully eradicated H pylori will be included if follow-up testing by stool
             antigen, urea breath testing, or biopsy is negative

          -  Celiac disease excluded by serologies or biopsy

        Exclusion Criteria:

          -  Patients with IBS predominant symptoms that are not well controlled

          -  Patients with a diagnosis of GERD who have uncontrolled heartburn

          -  History of esophagitis, ulcer disease, or other organic upper GI disease, including a
             diagnosis of celiac disease, gastroparesis, or vascular disorders of the upper GI
             tract

          -  History of surgery involving the esophagus, stomach, or duodenum

          -  Known lactose intolerance, unless symptoms persist on a lactose free diet

          -  Known fructose intolerance unless symptoms persist on a fructose free diet

          -  Patients undergoing active titration of any medications

          -  Pregnant or breastfeeding women

          -  Prisoners
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: REFRESH: Receptivity Enhancement by Follicular-phase Renewal After Endometrial ScratcHing (NCT02061228)

Eligibility criteria:
Inclusion Criteria:

          -  Fresh IVF/ICSI cycle

          -  Antagonist down-regulation

          -  Signed informed consent

        Exclusion Criteria:

          -  Other known reasons for impaired implantation (i.e. hydrosalpinx, fibroid distorting
             the endometrial cavity, Asherman's syndrome, thrombophilia or endometrial
             tuberculosis)

          -  Oocyte donation acceptors

          -  Frozen egg transfers

          -  Embryos planned to undergo preimplantation genetic diagnosis (PGD)

          -  BMI >35 or <18

          -  Women already recruited for another trial on medically assisted procreation during the
             same cycle

          -  Women who have previously enrolled in the trial

          -  Those unable to comprehend the investigational nature of the proposed study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Intra-articular Injection in the Knee of Adipose Derived Stromal Cells and Platelet Rich Plasma for Osteoarthritis (NCT03089762)

Eligibility criteria:
Inclusion Criteria:

          -  patients age 50 or older who present with symptomatic primary osteoarthritis of the
             knee

          -  daily pain for the previous 3 months

          -  analgesics usage at least once a week

          -  less than 30 minutes of morning stiffness

          -  WOMAC score of ≤ 75 in the target knee

          -  Brandt Radiographic Grading Scale of Osteoarthritis grade 1 and 2

        Exclusion Criteria:

          -  evidence of secondary knee osteoarthritis

          -  severe osteoarthritis (Joint space width - JSW < 2 mm)

          -  prior intra articular injections within the previous one year prior to inclusion

          -  patients with clinically significant systemic disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Idiopathic Pulmonary Fibrosis Registry for Future Studies (NCT00815711)

Eligibility criteria:
Inclusion Criteria:

          -  any patient referred to the Interstitial Lund Disease clinic who is undergoing
             evaluation and or treatment for a new diagnosis of ILD. This can include patients
             referred for presumed pulmonary fibrosis/interstitial pneumonitis (IPF, UIP, NSIP),
             sarcoidosis, hypersensitivity pneumonitis, cryptogenic organising pneumonia,
             drug-induced, or other idiopathic ILDs.

        Exclusion Criteria:

          -  pregnancy

          -  inability to follow study requirements
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Entailment
Clinical trial: Functional Outcome After Incisional Hernia Repair: Open Versus Laparoscopic Repair (NCT00625053)

Eligibility criteria:
Inclusion Criteria:

          -  Informed consent

          -  Age 18 years or older

          -  Diagnosis of reducible incisional hernias up to 200 cm²

          -  Medically fit for general anesthesia

          -  Comprehension and use of French language

          -  Installed in the geographical region without foreseeable move for two years

        Exclusion Criteria:

          -  Incarcerated hernia

          -  Ongoing chronic pain syndrome, other than hernia origin

          -  Coagulation disorders, prophylactic or therapeutic anticoagulation, unable to stop
             platelet antiaggregation therapy 10 days before surgery

          -  American Society of Anesthesiology Class 4 and 5 patients

          -  Emergency surgery, peritonitis, bowel obstruction, strangulation, perforation

          -  Mentally ill patients

          -  Presence of local or systemic infection

          -  Life expectancy < 2 years

          -  Any cognitive impairment (Psychiatric disorder, Alzheimer's disease etc.)

          -  Morbid obesity (BMI over 40)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Osteoporosis Disease Management Demonstration Project (0000-037) (NCT00139425)

Eligibility criteria:
Inclusion Criteria:

          -  Members of the Henry Ford Health System

        Exclusion Criteria:

          -  Individuals who are not members of the Henry Ford Health System
Female
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.
Subject must be at most 89 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility? (NCT02992665)

Eligibility criteria:
Inclusion Criteria:

          -  Severe male factor infertility, Average response to COH,

        Exclusion Criteria:

          -  Poor responders,
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Mesh and Mesh Fixation in Laparoscopic Groin Hernia Surgery (NCT03755219)

Eligibility criteria:
Inclusion Criteria:

          -  All laparoscopic TEP and TAPP repairs that have been registered in the SHR from
             January 1, 2005 until December 31, 2017.

        Exclusion Criteria:

          -  Open repairs.

          -  Hernioplasties that were converted from laparoscopic to open surgery.

          -  Age < 15 years.

          -  Patients not having a 10-digit state-assigned Patient Identification Number.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Personal FET in RIF Patients According to Histological Dating of Endometrial of Natural/ Hormone Replacement Cycle (NCT03312309)

Eligibility criteria:
Inclusion Criteria:

        The inclusion criteria for RIF group were:

        •unexplained repeated implantation failure (RIF) which is defined as the absence of a
        gestational sac on ultrasound at 5 or more weeks after embryo transfer (ET) after 3 embryo
        transfers with high quality embryos or after the transfer of ≥10 embryos in multiple
        transfers.

        The inclusion criteria for control group were:

          -  age <35 years;

          -  regular menstrual cycles of 24-35 days;

          -  baseline follicle- stimulating hormone (FSH) < 9.0 IU/L;

          -  endometrial thickness ≥8.0 mm on the day of hCG administration.

        Exclusion Criteria:

          -  uterine abnormalities (double uterus, bicornuate uterus, unicornuate uterus);

          -  intrauterine adhesions（moderate - severe）, endometriosis, adenomyosis, untreated
             hydrosalpinx, uterine fibroids (submucosal fibroids, nonmucosal fibroids >4.0 cm
             and/or endometrial pressure)

          -  history of adverse pregnancy (including spontaneous abortion, stillbirth, and fetal
             malformation).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Gene Therapy Study for Hemophilia B (NCT02484092)

Eligibility criteria:
Inclusion Criteria:

          -  Able to provide informed consent and comply with requirements of the study

          -  Males ≥18 y.o. with confirmed diagnosis of hemophilia B (≤2 IU/dL or ≤2% endogenous
             factor IX)

          -  Received ≥50 exposure days to factor IX products

          -  A minimum average of 4 bleeding events per year requiring episodic treatment of factor
             IX infusions or prophylactic factor IX infusions

          -  No measurable factor IX inhibitor as assessed by the central laboratory and have no
             prior history of inhibitors to factor IX protein

          -  Agree to use reliable barrier contraception until 3 consecutive samples are negative
             for vector sequences

        Exclusion Criteria:

          -  Evidence of active hepatitis B or C

          -  Currently on antiviral therapy for hepatitis B or C

          -  Have significant underlying liver disease

          -  Have serological evidence* of HIV-1 or HIV-2 with CD4 counts ≤200/mm3 (* subjects who
             are HIV+ and stable with CD4 count >200/mm3 and undetectable viral load are eligible
             to enroll)

          -  Neutralizing antibodies reactive with AAV-Spark100 above and/or below a defined titre

          -  Participated in a gene transfer trial within the last 52 weeks or in a clinical trial
             with an investigational drug within the last 12 weeks

          -  Unable or unwilling to comply with study assessments
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction