araag2/NLI4PR huggingface dataset:
Clinical trial: A Phase II Study With Low-dose Recombinant Human IL-2 for the Treatment of Primary Sjögren's Syndrome (NCT02464319)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of a primary Sjögren´s Syndrome

          -  ESSDAI score ≥ 6

          -  Liver values above 1,5 ULN

          -  Stable low dose systemic use of Glucocorticoids（<=7.5mg） in the last 4 weeks before
             begin with Study medication

        Exclusion Criteria:

          -  Secondary Sjögren's Syndrome

          -  Pre-treatment with Cyclosporine A

          -  Receiving cyclosphosphamide, corticosteroid bolus with dose over 1 mg/kg, rituximab,
             belimumab, other immunosuppressives

          -  Infection

          -  Neoplasia

          -  Relevant cardiac, pulmonary, neurologic or psychiatric disease

          -  Life-Vaccination within 4 weeks before begin with study medication

          -  Pregnant or breast-feeding

          -  Weight under 45kg or more than 80kg
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Clinical and Molecular Manifestations of Genetic Disorders (NCT00001466)

Eligibility criteria:
Patients and their families with known or suspected genetic disorders within the following
        categories will be recruited:

        Hereditary connective tissue disorders;

        Phacomatoses;

        Chromosomal disorders;

        Dysmorphic syndromes;

        Neuromuscular or neurological disorders;

        Inherited immunological and hematologic disorders.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Obesity Childhood in Cuenca-Ecuador: Prevalence and Risk Factors (NCT01381978)

Eligibility criteria:
Inclusion Criteria:

          -  All children of selected sample with an approved consent by their parents

        Exclusion Criteria:

          -  Children with malformations that not permit take anthropometric measures.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 9 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Performance Evaluation of RealDetect™ COVID-19 RT-PCR Kit for the Detection of SARS-CoV-2 Virus (NCT04403672)

Eligibility criteria:
Inclusion Criteria:

          -  Samples with positive RT-PCR results with Ct value ≤30 for the COVID-19 gene(s) at
             IEDCR will be selected as COVID-19 positive.

          -  Samples with negative RT-PCR results with no amplification for the COVID-19 gene(s) at
             IEDCR will be selected as COVID-19 negative.

        Exclusion Criteria:

          -  Samples with equivocal/ambiguous RT-PCR results in terms of sigmoidal curve and Ct
             value will be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 65 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders (NCT00403598)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of a metabolic bone disorder

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Strength Training as a Supplemental Therapy of Androgen Deficiency of the Aging Male (ADAM) (NCT03282682)

Eligibility criteria:
Inclusion Criteria:

          -  Patients of secondary hypogonadism on testosterone replacement therapy, newly
             diagnosed patients of secondary hypogonadism.

        Exclusion Criteria:

          -  Regular strength training, medical treating osteoporosis, abnormal digital rectal
             results, conditions which are medical contraindications (without adjusting state):
             diabetes mellitus, severe cardiac arrhythmia, uncontrolled hypertension, unstable
             angina pectoris, chronic obstructive pulmonary disease, epilepsy, unstable bone
             lesions with high risk of fracture, prostate cancer or abnormal serum PSA levels
             without adverse histological examination.
Male
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study of S5G4T-1 in the Treatment of Papular-Pustular Rosacea (NCT03564119)

Eligibility criteria:
Inclusion Criteria:

          1. Patient must sign an Institutional Review Board (IRB) approved written informed
             consent for this study.

          2. Male and female 18 years of age and older.

          3. Patients must have clinical diagnosis of moderate to severe rosacea.

          4. Have a minimum total of 15.

          5. Have two nodules or less .

        Exclusion Criteria:

          1. Females, who are pregnant, breastfeeding, or planning a pregnancy within the period of
             their study participation or were found to have positive pregnancy test at baseline or
             screening visits.

          2. Presence of more than 2 facial nodules or any nodule greater than 1 cm.

          3. Current or past ocular rosacea (e.g., conjunctivitis, blepharitis, or keratitis) of
             sufficient severity to require topical or systemic antibiotics.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study of the Expression of Nogo and Reticulon Genes in Skeletal Muscle of Patients With Amyotrophic Lateral Sclerosis (NCT00213824)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with definite ALS

          -  Males or females

          -  Age > 18

        Exclusion Criteria:

          -  Patients with other neuromuscular affections
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Reduced Port Laparoscopic Gastrectomy for Gastric Cancer (NCT04295473)

Eligibility criteria:
Inclusion Criteria:

          1. Histologically confirmed adenocarcinoma of the stomach, T1-T4 stages.

          2. Eastern Cooperative Oncology Group performance status of 0 or 1.

          3. Adequate organ function.

        Exclusion Criteria:

          1. Patients had distant metastasis.

          2. oesophageal invasion of more than 3 cm.

          3. Borrmann type 4 or large (more than 8 cm) type 3 carcinoma.

          4. Previous chemotherapy or radiation therapy for any other malignancies.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Enhancing the Effectiveness of Physical Therapy for People With Knee Osteoarthritis (NCT01314183)

Eligibility criteria:
Inclusion Criteria:

          -  40 years of age or older

          -  Meet the American College of Rheumatology (ACR) clinical criteria for a diagnosis of
             knee OA. The ACR clinical criteria for knee OA includes knee pain plus 3 of the
             following 6 criteria:

          -  age > 50 years,

          -  morning stiffness of < 30 minutes,

          -  crepitus on active movement,

          -  tenderness of the bony margins of the joint,

          -  bony enlargement of the joint noted on exam,

          -  lack of palpable warmth of the synovium. Based on this criteria, a subject who is less
             than 50 years but has knee pain and 3 of the other 5 criteria would also be classified
             as having knee OA.

        Exclusion Criteria:

          -  do not meet the ACR clinical criteria for knee OA,

          -  are scheduled for total knee arthroplasty (TKA) surgery,

          -  have undergone TJA surgery on any lower extremity joint,

          -  exhibit uncontrolled hypertension (i.e. individuals not currently taking medication
             for hypertension whose systolic blood pressure is greater than 140 mm Hg or diastolic
             blood pressure greater than 90 mm Hg at rest),

          -  have complaints of low back pain or other lower extremity joint pain that affects
             function at the time of recruitment,

          -  have a history of neurological disorders that would affect lower extremity function
             (stroke, peripheral neuropathy, parkinson's disease, multiple sclerosis, etc.),

          -  are women who are pregnant.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: LC-NMR Study Biomarkers to Detect Lung Cancer (NCT02024113)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of a new lesion in the lung

        Exclusion Criteria:

          -  a prior diagnosis of cancer in the past

          -  Not fasted for at least 6 hours

          -  Plasma glucose concentration ≥ 200 mg/dl

          -  Intake of medication at the day of investigation

          -  History/treatment of cancer in the previous 5 years
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment