araag2/NLI4PR huggingface dataset:
Clinical trial: Impact of Cognitive Behavioral Therapy on Parasomnias (NCT04633668)

Eligibility criteria:
Inclusion Criteria:

          -  DSM 5 Parasomnia Disorder

          -  at least one parasomnia event per week

          -  daytime fatigue or sleepiness

          -  6 months in duration

        Exclusion Criteria:

          -  current use of agents known to triggers parasomnias such as Lithium carbonate,
             Thioridazine, Chlorpromazine, Perhphenazine, Methaqualone, or Amitriptyline,

          -  for participants taking benzodiazepines or Prazosin, a stable dose regime for the past
             4 weeks,

          -  excessive alcohol consumption defined as the consumption of > 10 alcoholic beverages
             per week
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? Entailment
Clinical trial: Dementia Early Recognition and Response in Primary Care (NCT00866099)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with memory or other cognitive impairments suggestive of dementia syndrome

          -  those with a formal diagnosis of dementia, of any type.

        Exclusion Criteria:

          -  Patients and carers who are already involved in concurrent research

          -  If the key professional feels that an approach to the person with dementia or their
             carer would be inappropriate, for example the dementia is very severe, or that an
             approach may increase distress

          -  and any other important reason that the key professional may have for why the person
             with dementia or their carer should not be contacted.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Full-Thickness-Gastroplication For The Treatment Of Gastroesophageal Reflux Disease GERD (NCT01453985)

Eligibility criteria:
Inclusion Criteria:

          -  persistent or recurrent symptoms despite continuous medical treatment, at least one
             typical reflux symptom (heartburn/ regurgitation/dysphagia/epigastric pain) and/or at
             least one atypical reflux symptom (cough/ asthma/hoarseness/distortion of taste),
             pathologic esophageal acid exposure as documented by a reflux-related DeMeester score
             ≥14.7, and symptom correlation ≥50%, and/or reflux episodes >73.

        Exclusion Criteria:

          -  any distinct hiatal hernia detectable by gastroscopy or barium radiography, dysphagia,
             esophageal strictures, poor physical status (American Society of Anesthesiologists
             (ASA) scores III and IV) and pregnancy.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: GnRh Antagonist Protocol With Delayed Start Stimulation in Patients With Poor Ovarian Response (NCT03134690)

Eligibility criteria:
Inclusion Criteria:

          -  a history of ovarian surgery;

          -  previous treatment using conventional protocols that yielded less than three oocytes;

          -  antral follicle count of less than 5 on menstrual cycle day 2-3; and basal serum FSH
             concentration between 10 and 19 IU/l.

        Exclusion Criteria:

          -  ovarian failure including basal FSH above 20 IU/l or no antral follicle by ultrasound
             examination;

          -  Endometriosis grade 3 or higher;

          -  Any contraindications to ovarian stimulation treatment.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Relationship Between the Residual Renal Function and Osteoporosis Treatment (NCT02304887)

Eligibility criteria:
Inclusion Criteria:

          -  Osteoporosis patients

        Exclusion Criteria:

          -  eGFR < 15
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Kidney Injury Severity and COVID-19 (NCT04386564)

Eligibility criteria:
Inclusion Criteria:

          -  Pneumonia confirmed by CT scans

        Exclusion Criteria:

          -  a history of chronic renal failure;

          -  a history of kidney transplantation;

          -  intake of substances with a history of renal toxicity (no later than a month before
             inclusion);

          -  patients with a single kidney;

          -  refusal of the patient to participate in the study;

          -  absence of SARS-CoV-2 virus smear from the nasopharynx in PCR.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Sedation During Muscle Biopsy in Patients With Duchenne Muscular Dystrophy (NCT01645098)

Eligibility criteria:
Inclusion Criteria:

          -  Patients undergoing a muscle biopsy for IRB11-00203.
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Parathyroid Hormone (PTH) for Osteoporosis in Postmenopausal Women (NCT00086619)

Eligibility criteria:
Inclusion Criteria:

          -  Three or more years after menopause

          -  Bone mineral density T-score < or = -2.0 by dual-energy x-ray absorptiometry (DXA) of
             vertebrae or femoral neck, or by quantitative computerized tomography (QCT) of
             vertebral body trabeculae

        Exclusion Criteria:

          -  Cannot walk without assistance

          -  Significant heart, kidney, liver, or malignant disease

          -  Current alcohol abuse

          -  Major psychiatric disorders

          -  Other current or past disorders known to affect bone

          -  Use of medications known to affect bone for > 7 days in the past 12 months

          -  Use of bisphosphonates or fluoride

          -  Abnormal blood calcium, PTH, 25-hydroxy vitamin D, creatinine, liver function tests,
             or complete blood count

          -  Elevated calcium levels in 24-hour urine collection
Female
No healthy subjects accepted to join the trial.
Subject must be at least 46 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: OLGA and OLGIM Stage System for Gastric Cancer (NCT03380052)

Eligibility criteria:
Inclusion Criteria:

          -  Control group

               -  those who were between 25 and 80 years old and did not have any evidence of
                  gastric cancer and gastric dysplasia, esophageal tumor and MALToma in upper
                  gastrointestinal endoscopy

          -  Gastric cancer group

               -  Patients diagnosed as gastric cancer in the upper gastrointestinal endoscopy at
                  the time of participating in the study between 25 and 80 years old.

        Exclusion Criteria:

          -  history of previous gastrointestinal surgery,

          -  any other malignancy

          -  cardia cancer

          -  who do not perform endoscopic biopsy

          -  pathologically proven gastric dysplasia
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 25 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: JZ Thickness as a Predictor of Recurrent Unexplained First Trimesteric Pregnancy Loss. (NCT03054558)

Eligibility criteria:
Inclusion Criteria:

          -  Females with history of recurrent pregnancy loss

          -  for control group healthy females with history of at least one uncomplicated full
             pregnancy.

        Exclusion Criteria:

          -  no history of endocrinal disorders

          -  no history of immunological diseases

          -  no history of pelvic pathology

          -  no history of uterine anomalies or cervical incompetence As a cause of recurrent
             pregnancy loss
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of Tongue Strengthening for Swallowing Problems (NCT01570023)

Eligibility criteria:
Inclusion Criteria:

          -  referral by a physician for swallowing evaluation because of suspected dysphagia

          -  complaint of difficulty swallowing

          -  aspiration or penetration of the laryngeal vestibule with liquids or semisolids OR
             post-swallow residue visible in the oral cavity, valleculae, or pharynx that is
             instrumentally documented by a participating SLP during a standard clinical
             videofluoroscopic swallowing study

          -  between the ages of 21 and 95

          -  ability to perform the exercise protocol independently or with the assistance of a
             caregiver

          -  physician approval of medical stability to participate

          -  decision-making capacity to provide informed consent (confirmed through discussion
             between the participating SLP and the subject's primary physician)

        Exclusion Criteria:

          -  degenerative neuromuscular disease

          -  poorly controlled psychosis

          -  patient unable to complete the exercise program

          -  allergy to barium (used in videofluoroscopic swallowing assessment)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 95 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment