araag2/NLI4PR huggingface dataset:
Clinical trial: Balloon Dilation in Selected Subjects With Refractory Eustachian Tube Dysfunction (NCT02114762)

Eligibility criteria:
Inclusion Criteria:

          -  has functional ventilation tube or a chronic perforation in at least one ear;

          -  history of Eustachian tube dysfunction and/or otitis media with effusion;

          -  history of middle-ear effusion at least once;

          -  otherwise healthy except for possible gastro-esophageal reflux disease (GERD),
             allergies, sinusitis;

          -  BMI of less than 35;

          -  no history of difficult intubation;

          -  no known family history of malignant hyperthermia.

        Exclusion Criteria:

          -  history of adverse reaction to any study-related medication and a suitable alternative
             is not available;

          -  current or past history of cancer;

          -  current or past history of vestibular pathology or cranial base surgery;

          -  craniofacial dysmorphology (examples: down syndrome, cleft palate);

          -  pregnancy or "at risk" and not using contraception;

          -  patulous Eustachian tube;

          -  non-patent nasal cavity;

          -  adenoids that block the Eustachian tube orifice;

          -  blood pressure greater than 140/90;

          -  had experimental drug or procedure in the previous 3 months;

          -  allergic to eggs, egg products, soy, or soy products;

          -  previously underwent balloon dilation of the Eustachian tube.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Amtolmetin Gaucil in Knee Osteoarthritis (NCT02865161)

Eligibility criteria:
Inclusion Criteria:

          1. Informed consent form for participation in the study;

          2. KOA (based on ACR, 1987)

          3. Age between 30-60 years old

          4. Previous regular administration of NSAIDs for at least 4 weeks (at maximum therapeutic
             dose)

          5. Dyspeptic symptoms (according to SODA questionnaire)

          6. Pain intensity in the investigated knee joint ≥ 40 mm according to VAS

          7. Subjects with systolic blood pressure ≤ 140 mm Hg and diastolic BP ≤90 mmHg against
             stable antihypertensive therapy.

        Exclusion Criteria:

          1. Contraindications to amtolmetin guacil (according to patient information leaflet)

          2. Subjects with SBP ≥140 mm Hg and DBP ≥90 mm Hg

          3. Signs of renal or hepatic failure;

          4. Pregnancy, lactation or planning for pregnancy.

          5. One of the following changes in laboratory values at screening HGB, WBC, ESR, ALT,
             AST.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Mobilization Effect on Hamstring Length (NCT04574700)

Eligibility criteria:
Inclusion Criteria:

          -  Minimum 20% length shorting

          -  NPRS more than 3

          -  Gender include male and female

          -  Age 40-65

          -  Pain more than 3 months.

          -  Patients with mild to moderate knee OA (primary and secondary) grade 1and 2 Kellgren
             and Lawrence classification system based on plain x-rays taken in supine lying
             position. They should satisfy the American College of Rheumatology Criteria for
             clinical classification of knee OA.

        Hamstring shortness screening criteria: following tests should be positive for participants
        to enroll in this study

          -  Active knee extension test

          -  90-90 test

          -  Sit and reach test

        Exclusion Criteria:

          -  Co morbidities (i.e. Systematic diseases)

          -  Patient on long-term Medications i.e. corticosteroid

          -  Patient with Spinal Surgery

          -  Recent trauma

          -  Hamstring contracture.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Gamma Knife Radiosurgery for Treatment of Essential Tremor (NCT02255929)

Eligibility criteria:
Inclusion Criteria:

          -  Men and women age 18 years or older

          -  Diagnosis of essential tremor as confirmed from clinical history and examination by a
             neurologist or neurosurgeon

          -  Tremor following prior first line therapy with either propranolol or primidone

          -  Must be able to undergo MRI of brain and CT of head for treatment planning

          -  Postural or intention tremor severity score of greater than or equal to 2 in one
             hand/arm as measured by the CRST rating scale

        Exclusion Criteria:

          -  Prior ipsilateral stereotactic radiosurgical ablation of the thalamus, ipsilateral
             deep brain stimulation, radiofrequency ablation of a ipsilateral thalamic target, or
             ultrasound ablation of an ipsilateral thalamic target

          -  Prior whole brain radiation therapy

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Multidisciplinary Follow-up of Patients With Amyotrophic Lateral Sclerosis (NCT03536962)

Eligibility criteria:
Inclusion Criteria:

        Amyotrophic Lateral Sclerosis fulfilling the El Escorial criteria (definite, probable,
        possible), primary lateral sclerosis, progressive muscular atrophy, progressive bulbar
        palsy

        Exclusion Criteria:

        Patients with other neurological diagnoses than mentioned in the inclusion criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Pain Catastrophizing-2 (SPAC-2) (NCT04805190)

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic knee OA

        Exclusion Criteria:

          -  Younger than 45 years of age or older than 85 years of age

          -  Prosthetic knee replacement or other clinically significant surgery to the arthritic
             knee

          -  Uncontrolled hypertension (>150/95)

          -  Heart disease including heart failure

          -  Peripheral neuropathy in which pain testing was contraindicated

          -  Systemic rheumatic disorders including rheumatoid arthritis, systemic lupus
             erythematosus, gout, and fibromyalgia

          -  Neurological diseases such as Parkinson's, multiple sclerosis, stroke with loss of
             sensory or motor function, or uncontrolled seizures

          -  Significantly greater pain in body sites other than in the knee

          -  Daily opioid use

          -  Hospitalization within the preceding year for psychiatric illness

          -  Currently pregnant or nursing/breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: MEPHISTO (Macrophage Phenotype In Metabolic Syndrome With Iron Overload) (NCT02066012)

Eligibility criteria:
Inclusion Criteria:

          -  • 18 years old and over

               -  written consent

               -  for groups M and HSD at least one criteria of the metabolic syndrome definition
                  according to the International Diabetes Federation

               -  for group M only hepatic iron overload mesured by IRM (above 50 µmol/g)
                  hyperferritnemia between 450 and 1500 µg/l

               -  for group T only BMI < 25 kg/m² Waist size < 80 cm for women and <94 cm for men

        Exclusion Criteria:

          -  persons under guardianship

          -  pregnancy

          -  active smoking

          -  current inflammatory or cancerous disease

          -  hereditary hemochromatosis

          -  use of anti-inflammatory, immunosuppressive or hypoglycaemic drugs

          -  hemolysis

          -  alcool consumption above 14 doses for women and 21 doses for men per week

          -  history of therapeutic phlebotomy

          -  inflammatory syndrome with CRP above 15 mg/l
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Role of Tc 99m MDP SPECT/CT in Osteoarthritis (NCT03290807)

Eligibility criteria:
Inclusion Criteria:

          -  Adult patient above 30 years old.

          -  Clinically diagnosed osteoarthritis before treatment.

          -  Patient with refractory active osteoarthritis (not responding to treatment).

          -  Ability to sleep in fixed position for about 25 minutes

          -  Ability to provide informed consent.

        Exclusion Criteria:

          -  Patient with resolved osteoarthritis.

          -  patient with other disease in joints:

               -  Avascular necrosis

               -  Stress fracture

               -  Neuropathic pain
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Coagulation Profile and Role of Heparin Like Effect in Patients With COVID-19 (NCT04668404)

Eligibility criteria:
Inclusion Criteria:

          -  Inclusion Criteria:

               -  Age 18-80 years

               -  Confirmed Covid19 patient with positive RT PCR

          -  Exclusion Criteria:

               -  Current therapy: Recent blood or blood component transfusion in the last 2 weeks.

               -  HIV positive/ AIDS patients

               -  Pregnancy

               -  Active malignancy within the last 5 years

               -  Not willing to participate in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction