araag2/NLI4PR huggingface dataset:
Clinical trial: Caplacizumab Single and Multiple Dose Study in Healthy Japanese and White Subjects. (NCT03172208)

Eligibility criteria:
Inclusion Criteria:

          -  BMI between ≥18 kg/m² and <30 kg/m² at time of screening

          -  Body weight between ≥45 kg and <100 kg

          -  Baseline vWF:Ag between ≥60% and <170% (0.6-1.7 IU/mL)

        Exclusion Criteria:

          -  History of and/or any sign or symptom indicating current abnormal hemostasis or blood
             dyscrasia, including but not limited to thrombocytopenia, thrombocytopathy,
             thromboasthenia, hemophilia, von Willebrand's disease, vascular purpura, bleeding gums
             and/or frequent nose bleeding, easy/spontaneous bruises, meno- or metrorrhagia,
             history of gastrointestinal bleeding or excessive bleeding after minor injury such as
             shaving.

          -  Family history of congenital vascular malformation (e.g., Marfan's Syndrome) and/or
             bleeding disorder (e.g., hemophilia, von Willebrand's disease, Christmas disease)

          -  Any surgical intervention (including tooth extraction) or trauma within the 4 weeks
             preceding screening for the study or any planned surgical intervention during the
             participation in the study

          -  Treatment with vitamin K, direct oral anticoagulant (DOAC), warfarin, high dose
             heparin within 2 weeks before screening
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effects of Group Cycling (Spinning®) With Knee Osteoarthritis: A Randomized Control Trial (NCT00917618)

Eligibility criteria:
Inclusion Criteria:

          -  symptomatic and radiographic knee OA

        Exclusion Criteria:

          -  severe patella femoral knee pain that would make cycling difficult

          -  medical condition which would prohibit an exercise program
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: The Primary Symptoms of GERD(Gastroesophageal Reflux Disease) in Chinese Outpatients in Gastroenterology Department (NCT02506634)

Eligibility criteria:
Inclusion Criteria:

          -  Consecutive patients aged 18-65 years who go to the gastroenterology clinic presented
             with upper gastrointestinal discomfort, such as heartburn, regurgitation, dysphagia,
             substernal pain, epigastric pain, epigastric burning, early satiety, postprandial
             fullness.

          -  Whose previous symptoms should last for at least 3 months and be at least 3 days per
             week in frequency with moderate severity.

          -  Able to fill in the questionaires.

        Exclusion Criteria:

          -  gastric or duodenal ulcers, upper GI neoplasms on upper endoscopy

          -  severe cardiac or pulmonary diseases, diabetes or rheumatic diseases

          -  history of operations in the upper GI tract

          -  renal failure or abnormal liver function

          -  use of non-steroidal anti-inflammatory drugs (NSAIDs)

          -  allergy to esomeprazole

          -  Pregnancy or lactating mother
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Pathophysiology of Tremor-modulating Mechanisms of Propranolol and Primidone in Essential Tremor (NCT04692844)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of essential tremor made according to the newest consensus statement on the
             classification of tremors

          -  patients initiated on propranolol or primidone

        Exclusion Criteria:

          -  a history of seizures

          -  a history of mental illness,

          -  having a cardiac pacemaker

          -  having metal material in the head (except dental material in the mouth)

          -  having a medication pump

          -  pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Progestin Treatment for Endometrial Stromal Cells in Adenomyosis (NCT00155051)

Eligibility criteria:
Inclusion Criteria:

          -  women with adenomyosis

          -  at early- to mid-secretory phases

        Exclusion Criteria:

          -  postmenopausal

          -  malignancy
Female
Accepts Healthy Volunteers
Subject must be at least 35 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: The Efficacy Study of FUROSAP: A Testosterone Booster Supplement In Humans. (NCT02702882)

Eligibility criteria:
Inclusion Criteria:

          1. Agrees to written as well as audio-visual informed consent.

          2. Ability to understand the risks/benefits of the protocol

          3. Male between 35-65 years of age.

          4. Diagnosed with Symptomatic hypogonadism

        Exclusion Criteria:

          1. Uncooperative Subjects

          2. Impaired hepatic function indicated by SGOT/SGPT >2.5 times the upper limit of normal.

          3. Abnormal liver or kidney function tests (ALT or AST > 2 times the upper limit of
             normal; elevated creatinine, males > 125 µmol/L or 1.4mg/dl, females > 110 µmol/L
             or1.2mg/dl)

          4. Patients suffering from CAD

          5. History of malignancy

          6. History of hypersensitivity to any of the investigational drugs

          7. Receiving any other testosterone booster therapy/medication/supplement within the last
             2 months

          8. History of coagulopathies

          9. High alcohol intake (>2 standard drinks per day)

         10. History of psychiatric disorder that may impair the ability of subjects to provide
             written informed consent.

         11. Any medical condition, where the investigator feels participation in the study could
             be detrimental to the subjects overall well-being.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Visual Function and Ocular Pigmentation in Albinism (NCT00001153)

Eligibility criteria:
Patients have been recruited into the study by referral from an ophthalmologist or
        pediatrician.

        Entrance into the study was dependent upon clinical evidence of decreased or absent
        pigmentation in skin, hair, and/or eyes.

        The definition was purposefully broad to include the broad range of phenotype variations
        and clinical heterogeneity.

        The purpose of the study id to be able to document iris and retina/choroidal pigmentation
        and correlated these finding with visual function.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? Entailment
Clinical trial: Non-invasive Cerebellar Stimulation on Motor Learning (NCT02559518)

Eligibility criteria:
Inclusion Criteria:

          -  Right-handed (assessed by Edinburgh Handedness Inventory)

          -  Healthy volunteers (self report)

          -  Absence of neurological and psychiatric diseases

          -  No history of severe musculoskeletal injury to wrists and fingers

          -  Without using drugs or neuroactive substances regularly

        Exclusion Criteria:

          -  Pregnancy

          -  Presence of metallic implant close to the target stimulation area

          -  Acute eczema under the target stimulation area

          -  Pacemaker

          -  History of seizures or epilepsy

          -  Hemodynamic instability
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Normal Values for Esophageal and Pyloric Impedance Planimetry Under General Anesthesia (NormaFLIP) (NCT02905669)

Eligibility criteria:
Inclusion Criteria:

          -  Subject older than 18 years and younger than 80 years

          -  Subject referred for upper gastro-intestinal endoscopy under general anesthesia for
             anemia, intestinal metaplasia in the stomach, Helicobacter pylori screening, or
             submucosal dissection

          -  Subject with health insurance

          -  Written informed consent

        Exclusion Criteria:

          -  Patient younger than 18 years or older than 80 years

          -  Pregnancy or breast feeding

          -  Previous history of esophago-gastric surgery or vagotomy

          -  Previous history of Parkinson disease or diabetes mellitus

          -  Contra-indication to upper gastro-intestinal endoscopy

          -  Esophageal varices

          -  Esophageal diameter smaller than 5 mm

          -  Contra-indication to general anesthesia

          -  Hiatal hernia greater than 3 cm on endoscopy

          -  Esophageal or gastric cancer otherwise than superficial lesion with indication of
             submucosal dissection

          -  Typical symptoms (heartburn, regurgitation) of gastro-esophageal reflux disease and/or
             gastroesophageal reflux disease (GERD)-Q score greater or equal to 8

          -  Nausea, vomiting or epigastric pain

          -  Dysphagia with Sydney score greater ou equal to 50

          -  Incapability to give consent

          -  No written informed consent

          -  Participation to another study at the same time
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Prolotherapy Intervention Effect in Patient With Knee Osteoarthritis (NCT04557943)

Eligibility criteria:
Inclusion Criteria:

          1. The patient provides consent to be part of the research.

          2. The diagnosis of Knee Osteoarthritis was made based on clinical criteria/radiology
             American College of Rheumatology (ACR) 2012 with radiology grading according to
             Kellgren-Lawrence 2-3

        Exclusion Criteria:

          1. The Patient has received other forms of intraarticular injection therapy.

          2. The patient has received Non Steroid Anti inflammation drug (NSAID) therapy for one
             week before the start of the intervention.

          3. The patient has one or more contraindications for prolotherapy (e.g., Abscess,
             cellulitis, or septic arthritis).

        Drop Out Criteria :

          1. The patient has undergone a strenuous physical activity that precipitates a degree of
             complication (i.e., joint effusion).

          2. The use of NSAID within one week after the intervention.

          3. The patient does not adhere to the intervention.

          4. The patient developed or being diagnosed with osteoarthritis or other forms of
             inflammatory disease in other joints.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment