Clinical trial: Based on the Ultrasound Evaluating the Effect of Xiaozhong Fang Particles for Knee Osteoarthritic With Synovial Fluid (NCT03586700)

Eligibility criteria:
Inclusion Criteria:

          -  1) the American Society of Rheumatology established the diagnostic criteria for knee
             OA in 2001;

          -  2) Kellgren/Lawrence score of knee joint grade as I,II and early III.

          -  3) According to "Principles of clinical guidance for new drugs of traditional Chinese
             Medicine ",diagnosed as "Xi Bi Disease".

          -  4) Patients with informed consent.

          -  5)Blood and urine routine tests, liver and kidney functions, electrocardiogram were
             normal before recruitment.

          -  6) Patients were not treated with NSAIDS drugs or hormone drugs, and no patients were
             treated with drugs related to this disease at least 2 weeks.

        Exclusion Criteria:

          -  1)Patients suffer from other rheumatic and metabolic diseases such as gout, rheumatoid
             arthritis, diabetes and so on.

          -  2) Patients with knee joint inflammatory infection, such as suppurative and
             nonspecific.

          -  3)Patients accompanied by traumatic synovitis, Villonodular pigmented synovitis,
             synovial membrane of the knee is the main lesion.

          -  4) Patients with informed consent.

          -  5)The color of joint fluid of patients' knees is pink or other color or cloudy; the
             white blood cell counts > 1000 /mm3 or with crystal in the joint fluid.

          -  6)Patients blood RF > 30IU/ml, ESR > 20mm/h, CRP > 10mg/L.

          -  7)Patients combined with severe cardiovascular, cerebrovascular, liver, kidney and
             other primary diseases and mental diseases.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment