araag2/NLI4PR huggingface dataset:
Clinical trial: Electronic Tools to Assist With Identification of and Counseling for Overweight Patients (NCT00973661)

Eligibility criteria:
Inclusion Criteria (physicians):

          -  Consenting physicians from the Northwestern Memorial General Internal Medicine (NMFF
             GIM) practice

        Exclusion Criteria (physicians):

          -  Study investigators will be excluded from participation (Dr. David Baker, Dr. Joyce
             Tang)

        Inclusion Criteria (patients):

          -  Adults ages 18-65 seen at the NMFF GIM who are patients of consenting physicians

          -  Have at least one appointment at the NMFF GIM clinic between 9/1/09-2/28/10

          -  Body mass index (BMI) 27-29.9 at one or more visits between 9/1/09-2/28/10

        Exclusion Criteria (patients):

          -  Patients without at least one recorded height measurement from any prior visit or
             without weight information from a visit within the 6 month target window will be
             excluded due to inability to calculate BMI.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (NCT01322165)

Eligibility criteria:
Eligible subjects must have one of the conditions listed below and be enrolled in-person at
        one of the participating clinical centers.Contact the study coordinator at the location
        nearest you for more information about participation.

          -  Marfan syndrome

          -  Turner syndrome

          -  Ehlers-Danlos syndrome

          -  Loeys-Dietz syndrome

          -  FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 genetic mutation

          -  Bicuspid aortic valve without known family history

          -  Bicuspid aortic valve with family history

          -  Bicuspid aortic valve with coarctation

          -  Familial Thoracic Aortic Aneurysm and DissectionsYes

          -  Shprintzen-Goldberg syndrome

          -  Other aneurysms and dissections of the thoracic aorta not due to trauma, <50yo

          -  Other congenital heart disease (e.g., Tetralogy of Fallot, coarctation)

        Exclusion Criteria:

          -  Inability of the patient, parent or guardian to give consent.

          -  Unwillingness to provide a blood or buccal specimen.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: MSCT Chest in Suspected COVID-19 Patients (NCT04492865)

Eligibility criteria:
Inclusion Criteria:

          -  patients presented by fever, myalgia or respiratory symptoms

          -  Close contact with a confirmed COVID-19 patient

        Exclusion Criteria:

          -  pediatric patients

          -  patients refuse any of the following: MSCT chest, taking of nasopharyngeal swabs or
             blood sample

          -  chest MSCT -Angiography was done for suspected vascular complications (e.g., pulmonary
             embolism)

          -  severely dyspneic patients with motion artifact on MSCT images.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Directional Versus Nondirectional DBS for ET (NCT04828798)

Eligibility criteria:
Inclusion Criteria:

          -  A tremor syndrome of bilateral upper limb action tremor with at least 3 years'
             duration

        Exclusion Criteria:

          -  Patients who have decided not to receive DBS for control of their
             medication-refractory essential tremor.

          -  Patients with secondary tremor (ie not Essential Tremor), such as side effects from
             medications, secondary to another identified neurologic disease (eg multiple
             sclerosis, -----Parkinson's disease, dystonia).

          -  Prior history of deep brain stimulation.

          -  Prior history of thalamotomy.

          -  A history or signs of dystonia, ataxia or parkinsonism.

          -  Task specific tremor.

          -  Orthostatic tremor.

          -  Patients with cardiac pacemakers, defibrillators, or neurostimulators.

          -  Patients who require MRI, ECT, rTMS, or diathermy.

          -  Subjects with other type of neurological disease or injury.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Immunogenetics Predictors With COVID-19 (NCT04390269)

Eligibility criteria:
Inclusion Criteria:

          -  Adult subjects (> 18 years old) with COVID 19 infection.The patients will be
             classified on the basis of the severity of the disease.

        Exclusion Criteria:

          -  -patients have symptoms of fever and /or respiratory with negative PCR for COVID-19.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Zonisamide in the Treatment of Essential Tremor (NCT00616343)

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of Essential Tremor based on the Tremor Investigational Group criteria for
             definite or probable Essential Tremor.

          2. Age: 18 years or over.

          3. Willingness and ability to comply with the study requirements and give informed
             consent.

        Exclusion Criteria:

          1. Known history of psychiatric disorder, major depression, dementia, aplastic anemia, or
             Stevens-Johnson syndrome.

          2. Known alcohol or substance abuse in previous 12 months.

          3. Positive pregnancy test.

          4. Unwillingness to use adequate contraceptive methods if of childbearing potential.

          5. Known allergy to sulfonamides.

          6. Laboratory abnormalities prior to onset of trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Outpatient Treatment of Constipation in Children (NCT01582659)

Eligibility criteria:
Inclusion Criteria:

          -  Children between 2 and 16 years and referral to our out patient clinic with either
             constipation or fecal incontinence.

          -  Patients must fulfill the Rome III criteria of constipation, which mean they must have
             at least 2 of the following characteristics: fewer than 3 bowel movements weekly, more
             than 1 episode of fecal incontinence weekly, large stools in the rectum by digital
             rectal examination or palpable on abdominal examination, occasional passing of large
             stools, display of retentive posturing and withholding behavior, and painful
             defecation.

        Exclusion Criteria:

          -  Children with known organic causes of constipation, including Hirschsprungs disease,
             spinal and anal congenital abnormalities, previous surgery on the colon, inflammatory
             bowel disease, allergy and metabolic or endocrine diseases.

          -  Children receiving drugs known to affect bowel function during a 2 month period before
             initiation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 16 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effectiveness of Hylan GF-20 on Joint Reaction Forces and Kinematic Patterns During Gait in Patients With Knee Osteoarthritis (NCT00147186)

Eligibility criteria:
Inclusion Criteria:

          -  ambulatory, unilateral knee OA of at leas 3 months confirmed by radiography, pain
             requiring NSAIDS for at least 2 months

        Exclusion Criteria:

          -  no trauma to target knee within last 5 years, prior viscosupplementation therapy,
             allergy to avian products, inflammatory disease, joint sepsis,varus/valgus >12
             degrees, clinically apparent tense effusion, oral corticosteroids, intra-articular
             injection in any joint within the last 3 months, venous or lymphatic stasis in the
             leg, claudication or PVD, major surgery, arthroplasty in the target joint,
             arthroplasty in non-target knee within the last 6 months, current malignancy or
             treatment within the last 5 years, except for non-melanoma skin cancer, planned
             surgery during the study period, diabetes requiring insulin, use of an investigational
             device or drug (including glucosamine and chondroitin sulfate) within 90 days before
             entering the study, significant psychiatric or neurological disorder, active alcohol
             abuse or drug abuse within the past year.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 41 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Amyotrophic Lateral Sclerosis Registry Rhineland-Palatinate (NCT01955369)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of amyotrophic lateral sclerosis according to revised El Escorial criteria

          -  minimum of 18 years

          -  minimum of 6 months of residency in Rhinelnad-Palatinate

        Exclusion Criteria:

          -  patients below 18 years

          -  ALS patients outside Rhineland-Palatinate
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: A Prospective Study of Post-operative Opioid Use in General Surgery Patients (NCT02782884)

Eligibility criteria:
Inclusion Criteria:

          -  >= 18 years of age

          -  undergoing one of 9 elective outpatient operations: partial mastectomy, partial
             mastectomy and sentinel node biopsy, melanoma wide excision and sentinel node
             excision, thyroidectomy, parathyroidectomy, open inguinal hernia repair, laparoscopic
             inguinal hernia repair, laparoscopic cholecystectomy OR

          -  an inpatient on the general surgery service who took at least one oral narcotic

        Exclusion Criteria:

          -  allergic to all narcotics

          -  chronic opioid use

          -  history of opioid or benzodiazepine abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: The Value of Lateral Release in Reconstruction of the Diaphragmatic Hiatus Hernia (NCT04179578)

Eligibility criteria:
Inclusion Criteria:

          -  all patients with primary hiatus hernia type II-IV who are deemed suitable for surgery

        Exclusion Criteria:

          -  inability to understand the nature of the purpose of the study and/or to give informed
             consent.

          -  American Society of Anesthesiologists physical status-system (ASA) I-III

          -  Achalasia or another severe esophageal motor disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction