araag2/NLI4PR huggingface dataset:
Clinical trial: An Evaluation of the Medtronic Gatekeeper System in the Treatment of SUBJECTS With Gastroesophageal Reflux Disease (GERD) (NCT00200044)

Eligibility criteria:
Diagnosis and main criteria for inclusion:

          -  Subjects diagnosed with GERD with symptomatic improvement on PPIs.

          -  Subjects who have demonstrated a baseline 24 Hour pH ≥ 4% time with pH ≤ 4.0.

          -  Subjects with a baseline GERD-HRQL heartburn score of ≤11 on PPI and ≥ 20 off PPI.

        Diagnosis and main criteria for exclusion:

          -  Extensive Barrett's Esophagus (> 2 cm).

          -  Esophagitis (LA Classification Grades C or D).

          -  Previous history of gastroesophageal surgery, anti-reflux procedures, or
             gastroesophageal or gastric cancer.

          -  Large hiatal hernia (> 3 cm).

          -  Current complaints of clinical dysphagia evidenced by greater than one occurrence per
             month.

          -  Esophageal strictures

          -  Esophageal or gastric varices
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Inguinal Hernia and Arterial Disease (NCT04428138)

Eligibility criteria:
Inclusion Criteria:

          -  patients with inguinal hernia

        Exclusion Criteria:

          -  patients with malignancies
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Lipid Control in Hyperlipidemic Participants (MK-0653-179) (NCT01436253)

Eligibility criteria:
Inclusion criteria:

          -  Hyperlipidemic

          -  On therapy for hyperlipidemia for >=3 months without achieving target lipid values

        Exclusion criteria:

          -  Hypersensitivity or intolerance to hypolipemics

          -  Significant myopathy or rhabdomiolysis probably caused by hypolipemics

          -  Uncontrolled endocrine or metabolic disease which is known to affect lipid or
             lipoprotein values (for example, hypothyroidism and hyperthyroidism)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Long Protocol and Freeze All Embryos vs Antagonist Protocol With Fresh Embryo Transfer in PCOS Patients Undergoing ICSI (NCT03118830)

Eligibility criteria:
Inclusion Criteria:

          1. PCOS diagnosed by Roterdam criteria

          2. Protocol used for ovulation induction either long procol with freeze all embryos vs
             antagonist with fresh embryo transfer

          3. BMI less than 30

          4. ALL patients receiving adjuvant drugs for prevention of OHSS in the form of metformin,
             cabergoline as well as prophylactic hysteril , low dose asprin and LMW heparin
             following oocyte retrieval on a routine basis

        Exclusion criteria;

          1. PCOS on long protocol with fresh embryo transfer and those on antagonist protocol with
             freezing all embryo

          2. BMI more than 30

          3. PCOS patients not given adjuvant drugs in prophylaxis of OHSS

          4. Antagonist cases receiving agonist as trigger instead of HCG

          5. PCOS receiving more than 5000 IU HCG as trigger

          6. PCOS undergoing costing during ovulation induction

          7. PCOS with known medial problems as diabetes or hypertension
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: A New Method of Muscle Strength Testing Using a Quantitative Ultrasonic Technique and a Convolutional Neural Network (NCT04043832)

Eligibility criteria:
Inclusion Criteria:

          -  no major complaints of muscle numbness, spasm, or atrophy, muscle-related physical
             activity impairment or joint swelling and pain

          -  no obvious malformation in the lower limbs

          -  no disease history in the musculoskeletal system, nervous system, and peripheral
             blood,

          -  no history of severe trauma in the lower limbs

          -  joint mobility and muscle tension met the thresholds of muscle strength assessments

          -  no severe osteoporosis

          -  no acute inflammation or acute bone fracture repair

          -  between 18-55 years of age

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Home Blood Pressure Monitoring and Blood Pressure Control (NCT00202137)

Eligibility criteria:
Inclusion Criteria:

          -  adults age 18 years and older with essential hypertension.

          -  who are treated with medication to lower their blood pressure.

          -  whose mean daytime blood pressure at enrolment is 135/85 mm Hg or greater.

          -  and who are not currently using HBPM.

        Exclusion Criteria:

          -  a diagnosis of secondary hypertension.

          -  pregnancy.

          -  hypertension management primarily by a consultant.

          -  a disability that precludes use of a home blood pressure monitor.

          -  enrolled in another hypertension trial

          -  white coat hypertension
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Development of a Novel Human In Vitro Sarcoidosis Model (NCT01857401)

Eligibility criteria:
Inclusion Criteria:

          -  sarcoidosis, subjects (18 - 45 years of age), including 30 sarcoidosis, 15 latent TB
             and 15 healthy controls.

        Exclusion Criteria:

          -  pregnant women
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? Entailment
Clinical trial: Extension Study of NS-065/NCNP-01 in Boys With Duchenne Muscular Dystrophy (DMD) (NCT03167255)

Eligibility criteria:
Inclusion Criteria:

          1. Completed Study NS-065/NCNP-01-201 through Week 25.

          2. Willing and able to comply with scheduled visits, investigational product
             administration plan, and study procedures.

          3. Stable dose of glucocorticoid (GC), and is expected to remain on the stable dose for
             the duration of the study.

        Exclusion Criteria:

          1. Serious or severe adverse event in Study NS-065/NCNP-01-201 that precludes safe use of
             NS-065/NCNP-01.

          2. Patient had a treatment which was made for the purpose of dystrophin or its related
             protein induction after completion of Study NS-065/NCNP-01-201.

          3. Patient took any other investigational drugs after completion of Study
             NS-065/NCNP-01-201.

          4. Patient was judged by the investigator and/or the Sponsor that it was not appropriate
             to participate in the extension study for other reasons.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 10 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Personalized Prophylactic Treatment With Advate® in Severe or Moderate Haemophilia A Patients (NCT02622646)

Eligibility criteria:
Inclusion Criteria:

          -  Adults or adolescents older than 12 years

          -  Patients under Prophylactic treatment with Advate® for at least 1 year

          -  Written informed consent.

        Exclusion Criteria:

          -  History of FVIII inhibitor (titre ≥ 0.6 BU [Bethesda unit]) or detectable FVIII
             inhibitors at screening (titre ≥ 0.4 BU),

          -  Another haemostatic defect

          -  Need for major surgery.

          -  Withdrawal of informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated Enterocolitis (NCT02343562)

Eligibility criteria:
Inclusion Criteria:

          -  Hirschsprungs disease confirmed preoperative and postoperative specimen pathology

        Exclusion Criteria:

          -  Other cases of Enterocolitis and constipation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.
Subject must be at most 12 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Functional and Molecular Characterisation of Oesophageal Distal Epithelium: Correlations With Acid and Non Acid Reflux (NCT00231881)

Eligibility criteria:
Inclusion Criteria:

        Main inclusion criteria :

          -  Digestive symptoms suggestive of GORD (heartburn, regurgitation, epigastric pain), or
             dyspeptic syndrome (nausea, belch, bloating, epigastric discomfort).

          -  Need of upper GI endoscopy and pH monitoring.

          -  Normal propagation of oesophageal persitaltic waves (manometry < 6 months).

          -  Age 18 -70 yrs

          -  Signed informed consent

          -  Normal coagulation

        Exclusion Criteria:

          -  Barrett's oesophagus

          -  Previous oesophageal bleeding

          -  Need of NSAID treatment.

          -  Previous sus mesocolic surgery

          -  Alcool consumption > 40g/d, smoking > 10 cig/j

          -  Pregnancy or lack of contraceptive disposal, breast feeding.

          -  Allergy to Xylocaïne
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment