araag2/NLI4PR huggingface dataset:
Clinical trial: Study of Pitavastatin in Elderly Patients With Primary Hypercholesterolemia or Combined Dyslipidemia (NCT00330876)

Eligibility criteria:
Inclusion Criteria:

          -  Greater than or equal to 65 years of age

          -  Primary hypercholesterolemia

          -  Combined dyslipidemia

          -  Completed study NK-104-306 (NCT00257686)

        Exclusion Criteria:

          -  Failed to complete study NK-104-306(NCT00257686)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pharmacokinetic Study to Determine Time to Steady-state (NCT00911586)

Eligibility criteria:
Inclusion Criteria:

          -  Male, age 18-75

          -  Morning serum testosterone (T) <300 ng/dL on two occasions

          -  Naive to androgen-replacement therapy or willing to wash-out from current T therapy

        Exclusion Criteria:

          -  Significant intercurrent disease

          -  Abnormal prostate digital rectal exam, elevated PSA, AUA symptom score >15 or history
             of prostate cancer.

          -  Serum transaminases >2 times upper limit of normal

          -  Serum bilirubin >2.0 mg/dL

          -  Hematocrit <35% or >50%

          -  BMI >36

          -  Untreated, obstructive sleep apnea.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Phase 3 Study of Dexpramipexole in ALS (NCT01281189)

Eligibility criteria:
Inclusion Criteria:

          -  Aged 18 to 80 years old, inclusive, on Day 1.

          -  Diagnosis of sporadic or familial ALS.

          -  Onset of first ALS symptoms within 24 months prior to Day 1.

          -  World Federation of Neurology El Escorial criteria are met for a possible,
             laboratory-supported probable, probable, or definite ALS diagnosis.

          -  Upright slow vital capacity (SVC) of 65% or more at screening.

          -  Patients taking or not taking Riluzole are eligible for this study: if a patient has
             never taken Riluzole, he or she is eligible; if a patient is currently taking
             Riluzole, he or she must have been on a stable dose for at least 60 days; if a patient
             has discontinued Riluzole, he or she must have stopped taking it for at least 30 days.

          -  Must be able to swallow tablets at the time of study entry.

        Exclusion Criteria:

          -  Other medically significant illness.

          -  Clinically significant abnormal laboratory values.

          -  Pregnant women or women breastfeeding.

          -  Prior exposure to dexpramipexole.

          -  Currently taking pramipexole or other dopamine agonists.

        Other protocol-defined inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy, Safety & Utilisation of Nuwiq, Octanate and Wilate in Previously Untreated & Minimally Treated Haemophilia A Patients (NCT03695978)

Eligibility criteria:
Inclusion Criteria:

          -  Male and female patients of any age and ethnicity

          -  Severe haemophilia A (FVIII:C<1%)

          -  Decision to prescribe Octapharma's FVIII concentrate before enrollment into the study

          -  Either

          -  No previous treatment with FVIII concentrates or other blood products containing FVIII
             (PUPs) OR

          -  Less than 5 Exposure Days (EDs) to FVIII concentrates or other blood products
             containing FVIII (MTPs), if

          -  their first ED occurred after 1st January 2015, AND

          -  they did not develop an inhibitor at any time point, OR

          -  they developed an inhibitor during treatment with an Octapharma FVIII concentrate AND
             continue treatment with THIS Octapharma FVIII concentrate

          -  Voluntarily given, fully informed written and signed consent obtained before any
             study-related data documentation is conducted (obtained from the patient's
             parent/legal guardian)

        Exclusion Criteria:

          -  Diagnosis with a coagulation disorder other than haemophilia A

          -  Concomitant treatment with any systemic immunosuppressive drug

          -  Participation in an interventional clinical trial during the time period evaluated

          -  Participation in another non-interventional study of Octapharma
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Marfan Syndrome Moderate Exercise Pilot (NCT04641325)

Eligibility criteria:
Inclusion Criteria:

          -  Must be between the ages of 12-21

          -  Diagnosis of Marfan Syndrome

          -  Must not have other conditions that limit the patients ability to perform exercise

        Exclusion Criteria:

          -  Patients who have undergone aortic surgery

          -  Patients with major congenital heart disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 21 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: North Health in Intellectual Disability (NCT03889002)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of intellectual disability

          -  Age 16 or older and providing consent to participate.

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.


Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Contradiction
Clinical trial: Combined Dehydropeiandrosterone and Growth Hormone in Women With Expected Poor Ovarian Response Undergoing ICSI (NCT02766764)

Eligibility criteria:
Inclusion Criteria:

          -  Women undergoing ICSI with expected poor ovarian response according to the Bologna
             criteria

        Exclusion Criteria:

          -  Body mass index >35 Kg/m2.

          -  Women with a single ovary.

          -  Allergy to DHEA or GH.

          -  Diabetic women on insulin as insulin lowers DHEA levels and might reduce its
             effectiveness
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 43 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study to Investigate the Safety, Tolerability and Efficacy of YH4808 in Patients With Reflux Esophagitis (NCT01538849)

Eligibility criteria:
Inclusion Criteria:

          1. Subject who has signed on the written consent

          2. Male and female aged 20 and over

          3. Endoscopically verified Reflux Esophagitis classified into Los Angeles classification
             Grade A, B, C or D within 2 weeks before randomisation

        Exclusion Criteria:

          1. History or presence of upper gastrointestinal anatomic or motor disorders

          2. Other exclusions apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Encouraging Physical Activity: Action Or Direction? (NCT04300634)

Eligibility criteria:
Inclusion Criteria:

          -  Being between the ages of 9-14

          -  Being literate in Turkish

          -  Not having any physical disability preventing them from doing physical activities

          -  Attending physical education class regularly

        Exclusion Criteria:

          -  Having a serious cognitive impairment

          -  Going to school on foot

          -  Physiotherapists to be selected for the physiotherapist group to work in the field of
             sports
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 14 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Etanercept Therapy for Sjogren's Syndrome (NCT00001954)

Eligibility criteria:
INCLUSION CRITERIA

        Documented primary or secondary SS.

        Absence of confounding health problems.

        No contraindications to etanercept therapy.

        SS patients cannot have sarcoidosis, HIV infection, or lymphoma.

        Patients must have one of the following abnormal autoimmune serologies associated with SS
        (i.e. positive ANA, RF, and anti-SS-A, or anti-SS-B).

        Patients may use pilocarpine provided that they hold their dose on visit days when saliva
        is collected.

        Patients taking DMARD's, such as hydroxychloroquine, must be on a stable dose.

        Participants may take NSAIDs or acetaminophen.

        EXCLUSION CRITERIA

        Patients must not have physical or mental conditions that may make them unable to comply.

        Subjects may continue their other long-term medications with the exception of tricyclic
        antidepressants and anti-cholinergics, which may affect salivary gland function.

        Patients cannot take experimental drugs during the duration of the protocol.

        Children will be excluded due to additional risks that may occur with etanercept.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment