araag2/NLI4PR huggingface dataset:
Clinical trial: RCT Novasure Versus Novasure + Mirena IUS in the Treatment of Menorrhagia (NCT01965587)

Eligibility criteria:
Inclusion Criteria:

          -  Anybody suitable for novasure ablation

        Exclusion Criteria:

          -  Mirena IUS is indicated as treatment
Female
Accepts Healthy Volunteers



Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy and Tolerability of Mud Packs Therapy in Osteoarthritis of the Hand (NCT00773682)

Eligibility criteria:
Inclusion Criteria:

          -  Patients suffering from osteoarthritis of the hands according to the ACR criteria

        Exclusion Criteria:

          -  Patients suffering from any other rheumatological disease other than osteoarthritis

          -  Patients that have been treated with mud-pack therapy and balneotherapy in the last 9
             months

          -  Contraindications to mud-packs and balneotherapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Risk Factors for Occurrence of Placenta Accrete Spectrum Following Primary Cesarean Delivery (NCT04264169)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with history of previous one caesarean delivery

          -  Patients who refused trail of vaginal birth after caesarean section

          -  Patients with permanent indication for caesarean section like contracted pelvis

          -  Patient without any history of medical diseases

        Exclusion Criteria:

          -  Patients with history of more than one previous caesarean delivery

          -  Patients with medical disorders complicating pregnancy kike preeclampsia and
             gestational diabetes mellitus

          -  Patients with known uterine abnormalities eg (Bicornuate uterus, Adenomyosis,
             Submucous fibroids and Myotonic dystrophy)

          -  Patients who are candidates for vaginal birth after caesarean section
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Iron Deficiency In Pulmonary Hypertension (NCT01288651)

Eligibility criteria:
Inclusion Criteria:

          -  Stable idiopathic pulmonary arterial hypertension (stable disease for at least 3
             months)

          -  iron deficiency (serum iron below 10 μmol/l, decreased transferrin saturation (< 15%
             in females and < 20% in males) and serum ferritin < 100 μg/l) irrespective of the
             coexistence of anaemia

        Exclusion Criteria:

          -  Current iron therapy (oral or iv)

          -  Current other study medication for PAH

          -  History of anaemia or current treatment for anaemia

          -  Liver function impairment

          -  Chronic disease other than PAH (rheumatism, asthma, chronic infection)

          -  Acute infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Impact of Iron Injection on Blood Donation (NCT03014921)

Eligibility criteria:
Inclusion Criteria:

          -  Male between 20 and 35 yo

          -  BMI between 18 and 30

          -  Ferritin < 50ug/l

          -  Transferrin saturation < 20 if ferritin between 20 and 50ug/l

        Exclusion Criteria:

          -  high level athlete

          -  blood donation within 6 months before the study

          -  liver disorder
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Safety and Efficacy in a ReAl-Life Study in Patients With Haemophilia Treated wIth NovoEight® for Surgery (NCT04808349)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female

          -  Regardless of age

          -  No inhibitor (anti-FVIII alloantibodies) at the time of treatment.

          -  No objections expressed to participate in the study after having been informed of its
             purposes and the data involved.

          -  No other inherited hemorrhagic disorders than HA

        Exclusion Criteria:

        In order to reflect the reality of daily practice, no criteria for non-inclusion are
        provided for other than the refusal of the patient or his or her legal representative to
        participate in the study or the existence in the patient of a contraindication to the use
        of turoctocog alfa (NovoEight®) treatment.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of the Safety and Effectiveness of Rilonacept for the Prevention of Gout Flares (NCT00610363)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female greater than 18 years of age;

          -  Previously met the preliminary criteria of the American Rheumatism Association (ARA)
             for the classification of the acute arthritis of primary gout;

          -  At least 2 gout flares in the year prior to the screening visit.

        Exclusion Criteria:

          -  Acute gout flare within 2 weeks of the screening visit and during screening;

          -  Persistent chronic or active infections;

          -  History of an allergic reaction to allopurinol;

          -  History or presence of cancer within 5 years of the screening visit.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Basic Study of Combination Therapy Based on APCC-induced FVllI Activation in Hemophilia A Patients With Inhibitors (NCT02554526)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with hemophilia A with inhibitors (Inhibitor titer; >0.5 Bethesda U/ml)

          -  Patients with agreement consents with the patients signatures

        Exclusion Criteria:

          -  Patients that do not fill the conditions described above
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Electronic Patient Reported Outcome (ePRO) Mobile Application Pragmatic Trial (NCT02917954)

Eligibility criteria:
Inclusion Criteria:

          1. a FHT patient at one of the FHT sites selected and is 60 years or older;

          2. physical capability to use a tablet and/or a caregiver who can use the tablet on their
             behalf;

          3. ability to read and write in English and/or the availability of a caregiver who can do
             so on their behalf;

          4. has complex care needs defined as two or more chronic conditions and 10 or more visits
             to their primary health care provider within the last 12 months; and

          5. be thinking about or ready to make changes to support their self-management.

        In addition patients can self-identify and join the study, as well as providers can
        identify other patients they feel fit our eligibility criteria that may not have been
        pulled from the EMR system. This allows eligible patients to enroll into the study that may
        have been missed when identifying patients through the EMR system.

        Exclusion Criteria:

        1. Absence of Inclusion Criteria
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Oral Contraceptives and Body Mass Index (NCT01170390)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-35

          -  BMI > 30kg/m2

          -  Proof of a normal breast and pelvic exam within last 9 months

          -  Self reported normal menstrual periods (24-35 days)

          -  Good general health

          -  In the investigator's opinion, are subject's veins suitable the repeat blood draws
             dictated by study protocol

          -  Single progesterone level during screening visit ≥ 3ng/mL

          -  Hematocrit ≥ 36%

        Exclusion Criteria:

          -  Contradictions to COCs (history of deep vein thrombosis,myocardial infection,
             uncontrolled hypertension, pulmonary embolus, diabetes with vascular changes, stroke,
             migraines with neurologic changes, breast cancer, impaired liver function,
             uncontrolled thyroid disease, hypersensitivity or allergy to birth control)

          -  Smoker (must smoke 0 cigarettes)

          -  Actively seeking/involved in a weight loss program

          -  Currently pregnant/seeking pregnancy in the next 6 months

          -  Currently breast-feeding

          -  Past or current diagnosis of polycystic ovarian disease

          -  Recent use of birth control (Depot medroxyprogesterone: 6 months, Progestin implants:
             6 months, Oral contraceptives, patch or ring: 2 months, Hormone impregnated IUD: 6
             months)

          -  Currently taking medication that interferes with COC's (Rifampin, Carbamazepine, St.
             John's Wort)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction