Clinical trial: To Evaluate the Efficacy and Safety Aliviador Compared to Gelol in Patients With Contusions, Sprains, Trauma and Muscle Injury. (NCT01097798)

Eligibility criteria:
Inclusion Criteria:

          -  Patients of both sexes, of any race, aged over 12 years.

          -  Ability to read, understand and sign the IC, in the case of minors consent of
             responsible;

          -  Clinical diagnosis of bruises, sprains, trauma, muscle damage occurred in less than 24
             hours or muscle pain, myofascial pain or tendinitis.

          -  Patients able to understand and maintain the clinical protocol.

        Exclusion Criteria:

          -  Known hypersensitivity to components of the formulas of both the drug test as the
             comparator.

          -  Known hypersensitivity to paracetamol.

          -  Location of the lesion with skin wound or irritated.

          -  Liver or kidney disease known.

          -  Pregnant or lactating women.

          -  Patients who require surgery or immobilization.

          -  Patients with fractures or rupture of the ligaments.

          -  Patients using anticoagulants.

          -  Patients with severe concomitant systemic diseases, such as cancer, diabetes, or
             acquired heart disease, hematological diseases, seizure disorders, autoimmune
             diseases, renal failure, severe infections, hormonal disorders and pulmonary
             disorders.

          -  History of alcoholism or illicit drug use;

          -  Use of NSAIDs, corticosteroids or venoterápicos, topics or any other form of
             administration.

          -  Conditions in the opinion of the researcher make the patient unsuitable to participate
             in the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction