Clinical trial: Ambulatory Screening for Specific Learning Disabilities (SLD) and Developmental Coordination Disorder (DCD). (NCT04122820)

Eligibility criteria:
Inclusion Criteria:

        The population studied is composed of children:

          -  from 8 to 12 years old

          -  seen for any reason for consultation in general practice

          -  Schooled in an ordinary environment since the Preparatory Course in France

          -  Francophone parents

          -  One of whose parents has signed the consent

          -  Consent of the child

          -  Social Insured

        Exclusion Criteria:

        The background and living conditions that may promote secondary learning disabilities, for
        example:

          -  Child with a known intellectual disability (Wisc)

          -  Child in IME (Institut Médico Educatif)

          -  Child followed in SESSAD (Specialised education service at home)

          -  Child not knowing how to answer the questions asked

          -  Child with a known etiology causing learning disabilities (epilepsy, autism spectrum
             disorder, hearing impairment, visual impairment (deafness, blindness, low vision))

          -  Child on treatment (antiepileptic, neuroleptic, antidepressant, anxiolytic)

          -  Child under the care of a psychiatrist,

          -  Child followed by the CMP (Centre médico-psychologique)

          -  Child living in an institution,

          -  Adopted child

          -  A child whose mother has experienced known depression during the child's early
             childhood (0-18 months) because it causes attachment disorders, which can impact the
             child's development, including learning

          -  Child of a family that has lived through more than two family recompositions

          -  Child known to be a victim of abuse.

          -  Out of school child.

        To determine the presence of an HV-Labile

          -  Child with a known visual correction greater than + or- 2 diopters

          -  Known amblyopic child

          -  Known strabic child

          -  Child with no known binocular vision.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Contradiction