araag2/NLI4PR huggingface dataset:
Clinical trial: Effects of Naturally Silicon-Rich Water on Bone Metabolism in Women (NCT01067508)

Eligibility criteria:
Inclusion Criteria:

          -  Body mass index (BMI) < 30

          -  Postmenopausal women with no evidence of osteoporosis by dual energy X-ray
             absorptiometry (DEXA) scan (T ≥ -2 in the total hip and lumbar spine).

          -  Pre- or peri-menopausal women with osteopenia but no evidence of osteoporosis by DEXA
             scan (-1.5 ≤ T ≤ -2 in the total hip and lumbar spine)

          -  No estrogens or corticosteroids

          -  No prior history of bisphosphonate medication

          -  Otherwise in good health with no significant illnesses which could affect bone
             metabolism such as hypercortisolism, untreated hypothyroidism, treatment with statins
             or other drugs affecting bone metabolism other than calcium and vitamin D3.

          -  No change in exercise regimen or calcium intake in the past 3 months.

          -  Subject must sign the Institutional Review Board-approved written informed consent
             prior to the initiation of any study specific procedures or randomization. A subject
             will be excluded for any condition that might compromise the ability to give truly
             informed consent for participation in the study.

        Exclusion Criteria:

          -  Males

          -  Premenopausal women with DEXA T scores ≥ -1.5 or ≤ -2.

          -  Postmenopausal women with DEXA T scores ≤ -2.
Female
Accepts Healthy Volunteers



Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pediatric Inguinal Hernia Repair: Are Muscle Relaxants Necessary? Endotracheal Intubation vs Laryngeal Mask Airway (NCT02696837)

Eligibility criteria:
Inclusion Criteria:

          -  Children aged 0-18 years

          -  Diagnosed with inguinal hernia or communicating hydrocele

          -  Due to undergo laparoscopic inguinal hernia repair

        Exclusion Criteria:

          -  Previous abdominal surgery

          -  Comorbidities that will effect surgical time, time under anesthesia, intragastric
             pressure and abdominal pressure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Optical Coherence Tomography Imaging of the Posterior Segment in High Myopia. (NCT00347451)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy young adult males with myopia <-8D

        Exclusion Criteria:

          -  Best corrected visual acuity <6/9

          -  Previous intraocular surgery

          -  Intraocular pressure >21mmHg

          -  Gonioscopic findings of angle closure

          -  Clinical evidence of pseudo-exfoliation, uveitis or pigment dispersion syndrome,
             corneal or media opacities, retinal pathology or neurological diseases

          -  Family history in a first degree relative of glaucoma or other optic neuropathy.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison Open Lichtenstein Repair and Totally Extraperitoneal Herniorrhaphy (NCT03820570)

Eligibility criteria:
Inclusion Criteria:

          -  inguinal hernia

        Exclusion Criteria:

          -  recurrent hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Collection of Biological Samples With Clinical Characterization of Covid-19 Patients (NCT04363385)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of COVID-19 confirmed on RT-PCR test or chest scanner

          -  Any age

          -  Membership in the general social security system

          -  Inform consent signed by the patient or by legal representatives for minors

        Exclusion Criteria:

          -  Refusal of the patient or one of the legal representatives
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Histamine Pharmacogenetics in Children With Atopic Dermatitis (NCT00277433)

Eligibility criteria:
Inclusion Criteria:

          -  Caucasian, Hispanic and African American children ages 6 months to 5 years with a
             diagnosis of atopic dermatitis within the last 12 months will constitute the candidate
             pool for enrollment into the study group. The diagnosis of atopic dermatitis will be
             determined by the presence of at least 3 major diagnostic features (i.e., pruritis,
             rash,relapsing-remitting presentation, family history or atopy) in addition to at
             least 3 minor features (including but not limited to xerosis, elevated serum IgE,
             ocular involvement, food allergy). Healthy Caucasian, Hispanic and African American
             children within the same age range will comprise the pool for enrollment into the
             control group.

        Exclusion Criteria:

          -  Any child with atopic dermatitis who has a documented history of asthma or
             bronchospasm or who is currently receiving treatment for either of these conditions
             will be excluded. Any control subject who has asthma or positive family history of
             allergy or atopic disease in a first-degree relative (biological mother, father or
             siblings) will also be ineligible for enrollment.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.
Subject must be at most 5 Years

Patient description (medical language): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient description (patient's own words): I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Does the patient match the trial criteria? Entailment
Clinical trial: Correlates of GERD Symptom Severity (NCT03020550)

Eligibility criteria:
Inclusion Criteria:

          -  Adults ages 21-70 years old

          -  Heartburn symptoms 3 or more days per week with an average daily symptom severity of 3
             or more on a 7 day baseline symptom diary

          -  English language proficiency

          -  Willingness to be videotaped and connected to physiologic monitoring devices during
             the visit

        Exclusion Criteria:

          -  Diagnosis of Crohn's disease, systemic sclerosis, known active ulcer disease, gastric
             cancer, or untreated/active Barrett's esophagitis based on subject self-report and/or
             medical record review

          -  Heavy alcohol use (> 6 drinks/week for women and > 13 drinks/week for men)

          -  Pregnant women.

          -  Dementia or significant memory difficulties

          -  Severe, unstable psychiatric disease

          -  Greater than 15 doses of nonsteroidal anti-inflammatory drugs (NSAIDS) within the
             prior 30 days (aspirin ≤ 325 mg daily permitted) or ongoing NSAID use at a level
             deemed likely to interfere with the study

          -  Failure to complete the baseline symptom diary for at least 6 of 7 days

          -  Change in GERD treatment regimen within the last 2 weeks (subjects may use antacids,
             H2 receptor blockers, and/or proton pump inhibitors as long as they are symptomatic on
             a stable regimen)

          -  Allergy to adhesives

          -  Inability to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Vital Signs Patch Early Feasibility and Usability Study v1.0 (NCT02524470)

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female in-patients with vital signs considered 'stable' by clinical
             caregivers.

        Exclusion Criteria:

          -  Pediatric patients

          -  Female patients who are pregnant

          -  Patients with internal or external defibrillators

          -  Patients who have undergone surgery and still have a fresh incision on the chest.

          -  Patients with skin damage on the chest such as burns, irritation, infections, wounds,
             etc.

          -  Patients in the Critical Care Unit (CCU)

          -  Patients who otherwise satisfy any of the contraindications associated with the VSP
             system.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Phase 1/2 Trial of Gavo-cel (TC-210) in Patients With Advanced Mesothelin-Expressing Cancer (NCT03907852)

Eligibility criteria:
Inclusion Criteria:

          -  Patient is > 18 years of age at the time the Informed Consent is signed.

          -  Patient has a pathologically confirmed diagnosis of either Malignant
             Pleural/Peritoneal Mesothelioma (MPM), Serous Ovarian Adenocarcinoma,
             Cholangiocarcinoma, or Non-Small Cell Lung Cancer (NSCLC).

          -  Patient's tumor has been pathologically reviewed by the central laboratory with
             confirmed positive MSLN expression on > 50% of tumor cells that are 2+ and/or 3+ by
             immunohistochemistry.

          -  Prior to gavo-cel infusion, patients must have received at least 1 systemic standard
             of care therapy for metastatic or unresectable disease with more details provided in
             the clinical protocol

          -  Patient has an Eastern Cooperative Oncology Group performance status 0 or 1.

          -  Patient has a left ventricular ejection fraction > 45% as measured by resting
             echocardiogram, with no clinically significant pericardial effusion.

          -  Patient is fit for leukapheresis and has adequate venous access for the cell
             collection.

          -  Patient must have adequate organ function as indicated by the laboratory values in the
             clinical protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Effectiveness of Manual Therapy in Dysmenorrhea (NCT03593057)

Eligibility criteria:
Inclusion Criteria:

          -  Women with menstrual pain of more than 6 months of evolution.

          -  Women with pain equal to or greater than 4 on the visual analogue scale in more than
             half of their one-year menstrual cycles.

        Exclusion Criteria:

          -  Hormone treatment

          -  Contraindication to any of the treatments

          -  Participate in this period of no functional recovery program or physiotherapy
             treatment.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction