araag2/NLI4PR huggingface dataset:
Clinical trial: Microbiota and Bone Fragility:Study of the Relation Between Gut Microbiota and Bone Microarchitecture (NCT04265742)

Eligibility criteria:
Inclusion Criteria:

          -  post-menopausal women

          -  with a normal Bone Mineral Density (T-score >-1.5) at the 3 sites (lumbar spine, total
             hip and femoral neck) or with osteoporosis (T-score ≤ -2.5) at least at one of the 3
             sites.

        Exclusion Criteria:

          -  Current antibiotherapy or in the last 6 months or repeated antibiotherapy

          -  Current corticotherapy or stopped for less than 6 months

          -  Current treatment of osteoporosis or having lasted more than 3 months in the last 5
             years

          -  Current hormonal treatment for menopause

          -  Current or discontinued drugs that may affect bone metabolism (eg anti-aromatase)

          -  Known hepatic, cardiac or respiratory insufficiency

          -  Pathologies that may affect bone metabolism, particularly severe renal insufficiency

          -  Serious illnesses, particularly disabling and chronic diseases of the gastrointestinal
             tract

          -  Diseases characterized by substantial disorders of the gut microbiota (eg severe
             obesity, BMI> 40 kg / m2, depression, poorly controlled diabetes)

          -  Psychiatric pathology hindering understanding

          -  Difficulty understanding oral French

          -  Person protected by law, unable to express her consent, subject to a protective
             measure or deprived of liberty.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Erythrocyte Apheresis Versus Phlebotomy in Hemochromatosis (NCT00509652)

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis

               -  Individuals who art homozygous for C282Y or H63D or "compound heterozygous" for
                  these tow variants and have ferritin levels higher than 300 micrograms/L or
                  transferrin saturation higher than 50%.

               -  Individuals heterozygous for C282Y or H63D if ferritin levels higher than 500
                  micrograms/L or transferrin saturation higher than 50%.

          2. Requirements to the patient Body weight higher than 65 kg and initial hemoglobin level
             higher than 12 g/dL.

        Exclusion Criteria:

          1. Contra-indications to either treatment modality

          2. Patients who are not able to co-operate

          3. Lack of informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment
Clinical trial: Stated-Preferences in Knee Arthroplasty (NCT03058380)

Eligibility criteria:
Inclusion Criteria:

          -  Age 40-80

          -  Knee Pain

        Exclusion Criteria:

          -  Inability to read, understand and give effective English consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Plasma RBP Levels in Patients With Idiopathic Hypogonadotrophic Hypogonadism (NCT01758094)

Eligibility criteria:
Inclusion Criteria:

        decreased serum testosterone concentration below the normal range (serum T < 300ng/dL), FSH
        and LH levels within or below the normal range, absence of a pituitary or hypothalamic mass
        lesions on MRI, presence of gonadotropin response to repetitive doses of GnRH, normal smell
        test and normal karyotypes

        Exclusion Criteria:

        previous androgen treatment, history of smoking, presence of bilateral anorchia,
        intellectual deficiency, diabetes mellitus, arterial hypertension or dyslipoproteinemia,
        medication of any kind and drug abuse. Because of possible confounding effects, patients
        with other hormone deficiencies were excluded.

        -
Male
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 26 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Impact of Biological Point of Care Devices Implementation on the Length of Stay of Patients in Emergency Room (NCT03840564)

Eligibility criteria:
Inclusion Criteria:

          -  Any patient consulting in the emergency department during the study period

        Exclusion Criteria:

          -  Patients attending the emergency departments as part of dressing or trauma follow-up
             consultations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.


Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Entailment
Clinical trial: Radiological Analysis on Patients With Achondroplasia Disorder (NCT04184817)

Eligibility criteria:
Inclusion Criteria:

          -  Boys and girls.

          -  Aged from 0 to 18 years old.

          -  Subjects with an Achondroplasia diagnosis.

          -  Patients or parents/ legal guardian must provide non opposition prior to participation
             in the study.

        Exclusion Criteria:

        - Patients or patient's parents or legal guardian whose have an objection for using their
        data.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Entailment
Clinical trial: A Clinical Study to Assess the Efficacy and Safety of Amizon® Max in the Treatment of Moderate Covid-19 (NCT04682873)

Eligibility criteria:
Inclusion Criteria:

        Each subject must meet all of the following inclusion criteria to be randomized to
        treatment:

          1. Willing and able to provide written informed consent

          2. Aged ≥ 18 years

          3. SARS-CoV-2 infection confirmed by PCR ≤ 4 days before randomization

          4. Currently hospitalized due to SARS-CoV-2 infection with fever, defined as body
             temperature ≥ 37.8 °C

          5. Modified World Health Organization (WHO) Ordinal Scale for Clinical Status Patient
             state in Covid-19: score 4 i.e. hospitalized, virus-positive, oxygen by mask or nasal
             prongs

        Exclusion Criteria:

        The subject is excluded from the trial if any of the following criteria apply:

          1. Concurrent treatment with other agents with actual or possible direct acting antiviral
             activity against SARS-CoV-2 is prohibited < 24 hours prior to start of IMP treatment

          2. Requiring mechanical ventilation at screening or it is expected within 24 h after
             inclusion

          3. Expected survival time < 72 hours for any reason

          4. Positive pregnancy test

          5. Breastfeeding woman

          6. Presence of renal dysfunction defined as estimated glomerular filtration rate (eGFR)
             <60 mL/min, total bilirubin ≥ 2.0 mg/dL, Thyroid stimulating hormone (TSH) outside
             normal range and / or Aspartate aminotransferase (ASAT)/ Alanine aminotransferase
             (ALAT) above threefold upper limit of normal range (known from patients medical
             history)

          7. Known hypersensitivity to the trial drug, the metabolites, or formulation excipient

          8. History or presence of drug or alcohol abuse

          9. History or presence of diseases of thyroid gland
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of the Effectiveness of Internet Based Nutrition and Physical Activity Education Programme in Adolescents (NCT02297919)

Eligibility criteria:
Inclusion Criteria:

          -  All students who accept to participate in the study

        Exclusion Criteria:

          -  Students who refused to participate in the study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Proteomics Study of Mild Cognitive Impairment and Alzheimer's Disease (NCT04804618)

Eligibility criteria:
Inclusion Criteria:

          1. Older than 55-year-old，male or female.

          2. patients meet the diagnosis of mild cognitive impairment (MCI) or Alzheimer's
             disease(AD) or whose family members were diagnoed with AD

          3. Complete self-rating scale for memory impairment (AD-8 scale)

          4. Those who agree to participate in clinical research and sign informed consent.

        Exclusion Criteria:

          1. Patients with acute cardiovascular and cerebrovascular diseases, acute infections
             (pneumonia, urinary tract infection, oral infection, digestive tract infection),
             severe renal dysfunction, and uremia;

          2. Pregnant or lactating women;
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 55 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: A Pilot Randomized Controlled Trial for Hand Osteoarthritis (NCT04784065)

Eligibility criteria:
Inclusion Criteria:

          -  Enrolled to receive medical care at the Michael E. DeBakey VA Medical Center

          -  At least 3 joints affected by distal interphalangeal (DIP) nodal hand OA

          -  DIP nodal hand OA will be defined as Heberden's nodes on physical exam.

          -  Sufficiently severe frequent pain of at least one DIP

          -  Frequent pain: pain on most days of the month for at least one month in the last year.

          -  Minimum VAS pain severity of 40 on a 0 - 100 scale

        Exclusion Criteria:

          -  History or current inflammatory arthritides (examples: gout, psoriatic arthritis, and
             rheumatoid arthritis)

          -  Prior surgery on the DIP joints

          -  Planned surgery for the DIP joints

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment