araag2/NLI4PR huggingface dataset:
Clinical trial: Effectiveness of Manual Therapy and Exercise in Shoulder OA (NCT02587559)

Eligibility criteria:
Inclusion Criteria:

          -  over 50 years of age

          -  Osteoarthritis > Grade 3 on the Kellgren-Lawrence scale

          -  Presence of at least two of the following findings:

          -  morning stiffness that resolves within 60 minutes

          -  pain > 3/10 on a numerical pain rating scale

          -  asymmetrical mobility in either contralateral elevation and/or glenohumeral rotation,
             or notable crepitus with active motion.

        Exclusion Criteria:

          -  medical co-morbidities (diabetes and rheumatoid arthritis)

          -  adhesive capsulitis

          -  fractures

          -  scapulothoracic paresis

          -  surgery in past year

          -  inability to speak English language
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction
Clinical trial: COMPARISON OF LAPAROSCOPIC TOTAL EXTRAPERITONEAL HERNIA REPAIR AND LICHTENSTEIN HERNIA REPAIR (NCT03935503)

Eligibility criteria:
Inclusion Criteria:

          -  Unilateral inguinal hernia (diagnosed by physical examination or imaging)

          -  Sexual Active

          -  Male gender

          -  aged between 18 and 65

          -  ASA 1-2

          -  EHS Classification (Primary, lateral or medial, 1 and 2)

        Exclusion Criteria:

          -  Patients with previous abdominal and inguinal hernia surgery

          -  ASA 3-4

          -  Sexually inactive

          -  Emergency patients (Etrangule inguinal hernia)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Treatment of Optic Neuropathies Using Autologous Bone Marrow-Derived Stem Cells (NCT02638714)

Eligibility criteria:
Inclusion Criteria:

          -  Patient should suffer from Optic Nerve Atrophy diseases like diabetic retinopathy and
             retinal pigmentation.

          -  Age in between 18-55 years old

          -  Willingness to undergo bone marrow derived autologous cell therapy.

          -  Ability to comprehend the explained protocol

          -  Ability and willingness to regularly visit to hospital for protocol and follow up

        Exclusion Criteria:

          -  Patients with preexisting or current systemic disease such as lung, liver,
             gastrointestinal, cardiac, immunodeficiency, syphilis, or clinically relevant
             polyneuropathies.

          -  History of life threatening allergic or immune- mediated reaction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study Of Cutaneous Disease Accompanied With Pruritus In Pediatrics (NCT00257582)

Eligibility criteria:
Inclusion Criteria:

          -  Chronic urticaria

          -  Eczema & dermatitis group

          -  Atopic dermatitis

          -  Prurigo group: Acute prurigo, Prurigo subacuta, Chronic prurigo

          -  Pruritus cutaneous: Systemic pruritus cutaneous, Topical pruritus cutaneous

          -  Giving informed consent

          -  Children who have 2 grades or more pruritus score when assessed by the investigator or
             sub-investigator with the criteria for the diurnal or nocturnal pruritus score in the
             patient diary.

          -  Children with a pruritus severity of "2.Mild" or severer on the first day of the
             treatment period.

        Exclusion criteria:

          -  have a history of drug hypersensitivity

          -  are pregnant, lactating or possibly pregnant female children.

          -  have asthma that requires the treatment with corticosteroid.

          -  cannot avoid the use of external steroid classified into "strong", "strongest" or
             "very strong".

          -  have pruritus only on face and head.

          -  have inappropriate complication of dermal disorder that may influence on the
             evaluation of the study drug.

          -  are undergoing specific desensitization therapy or immunomodulation therapy or
             phototherapy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 14 Years

Patient description (medical language): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient description (patient's own words): I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy of Fluoroscopy-guided Epidural Anesthesia for Osteoporotic Vertebral Compression Fracture Treated by Percutaneous Vertebroplasty (NCT03621527)

Eligibility criteria:
Inclusion Criteria:

          -  - Two osteoporotic vertebra compression fractures in the low thoracic or lumbar spine

          -  men and women > 18 years old

          -  patients with healthcare insurance

          -  signed and dated informed consent

        Exclusion Criteria:

          -  men and women < 18 years

          -  pregnant or breastfeeding women

          -  patients under trusteeship or guardianship or patients under the protection of court

          -  bad comprehension or cooperation

          -  bleeding disorders

          -  local or general infection

          -  intracerebral or severe cardiac affections
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Misoprostol Versus Effox as Cervical Ripening Agent Prior Surgical Evacuation (NCT02738177)

Eligibility criteria:
Inclusion Criteria:

          -  healthy pregnant women candidate for surgical evacuation

          -  1st trimesteric pregnancy loss with gestational age 12 weeks or less (diagnosis was
             confirmed using transvaginal ultrasound according to the following criteria:
             Crown-rump length {CRL} of 7 mm or more and no heartbeat, Mean sac diameter {MSD} of
             25 mm or more and no embryo, absence of embryo with heartbeat 2 wk or more after a
             scan that showed a gestational sac without a yolk sac and absence of embryo with
             heartbeat 11 days or more after a scan that showed a gestational sac with a yolk sac)

          -  closed and firm cervix

        Exclusion Criteria:

          -  evidence suggesting spontaneous onset of abortion (vaginal bleeding or and uterine
             cramps), previous trial to induce abortion or the use of any cervical ripening agent
             during the current pregnancy, presence or suspicion of septic abortion (fever > 38
             degree Centigrade, offensive vaginal discharge & leukocytosis), Uterine anomalies or
             history of any cervical surgery or manipulation.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial (NCT04091698)

Eligibility criteria:
Inclusion Criteria:

          1. Patients free from any systemic disease according to the detailed questionnaire of the
             modified Cornell Medical Index 34.

          2. Patients not receiving any medication either topical or systemic that could cause
             lichenoid reaction during the 3 months before the study.

          3. Patients diagnosed by a dermatologist and oral medicine specialist as suffering from
             OLP.

          4. Patients clinically and histopathologically diagnosed as suffering from OLP according
             to World Health Organization's (WHO's) clinic-pathological diagnostic criteria for
             LP35.

          5. Patients who agree for the biopsy in undiagnosed cases.

          6. Patients who are willing to participate in this study (will give informed consent) and
             have the ability to complete the study.

               -  Exclusion criteria:

        (1) Patients taking systemic drugs such as systemic steroid, other immunosuppressive
        therapy for at least 8 weeks prior to the study.

        (2) Patients treated with any oral topical medications for at least four weeks prior to the
        study.

        (3) Patients with suspected restoration-related reaction. (4) Pregnant and lactating
        mothers.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effectiveness of Diaphragmatic Breathing on Reflux Symptoms in Outpatients (NCT04120025)

Eligibility criteria:
Inclusion Criteria:

          -  Adults with complaints of GERD, reflux, and/or heartburn symptoms

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Improving Pediatric Safety and Quality With Health Care Information Technology (NCT00134823)

Eligibility criteria:
Inclusion Criteria:

          -  Partners-affiliated pediatric practice providers utilizing Longitudinal Medical Record
             (LMR), which is an electronic health record system. Also the parents of the patients
             of the above noted pediatric providers.

        Exclusion Criteria:

          -  Non-Partners providers, or Partners providers who do not use LMR. Parents of patients
             not seen by Partners-affiliated pediatric providers who use LMR.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment