Clinical trial: Effectiveness of Curcumin-based Food Supplement in Reducing Pain and Inflammatory Component in Osteoarthritis (NCT04207021)

Eligibility criteria:
Inclusion Criteria:

          -  Presence of osteoarthritis of the knee. Traditional American College of Rheumatology
             criteria, which are based on the presence of pain (gonalgia) plus at least three of
             the following characteristics, will be used for the diagnosis of osteoarthritis of the
             knee:

          -  Age > 50 years

          -  Stiffness in the morning < 30 minutes

          -  Presence of articular rusting

          -  Painfulness of the bones

          -  Tumefaction of the bones

          -  Absence of palpable heat

        Exclusion Criteria:

          -  - pregnancy and breastfeeding (if the potential participant does not declare to be in
             a menopausal state)

          -  other specific contraindications/intolerances to the compounds contained in the
             supplement (e.g. celiac disease, allergy)

          -  simultaneous intake of other supplements

          -  to be at the time of enrolment for treatment with anti-inflammatory or pain-relieving
             treatment for other clinical conditions

          -  Participation in other clinical studies

          -  State of inability to understand or desire
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment