Clinical trial: Sustainable Method for Alzheimer's Prediction (NCT03654911)

Eligibility criteria:
Exclusion criteria for AD will be:

          -  frontotemporal dementia;

          -  behavioural variant of frontotemporal dementia;

          -  vascular dementia;

          -  extra-pyramidal syndromes;

          -  reversible dementias (including pseudodementia of depression);

          -  Lewy body dementia.

        The exclusion criteria for aMCI will be:

          -  mild AD, as diagnosed by standard protocols including National Institute on
             Aging-Alzheimer's Association workgroups (McKhann et al. 2011);

          -  evidence (including magnetic resonance imaging -MRI procedures) of concomitant
             dementia such as frontotemporal, vascular and reversible dementias (including
             pseudo-depressive dementia), marked fluctuations in cognitive performance compatible
             with Lewy body dementia and/or features of mixed dementias;

          -  evidence of concomitant extrapyramidal symptoms;

          -  clinical and indirect evidence of depression as revealed by the Geriatric Depression
             Scale GDS (Yesavage et al. 1982); scores lower than 14 (no depression);

          -  other psychiatric diseases, epilepsy, drug addiction, alcohol dependence, use of
             neuro/psychoactive drugs including acetylcholinesterase inhibitors;

          -  current or previous uncontrolled or complicated systemic diseases (including diabetes
             mellitus) or traumatic brain injuries.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Contradiction