Clinical trial: Efficacy and Safety of F-18 FPCIT PET in Parkinson's Disease and Essential Tremor Patients (NCT00468078)

Eligibility criteria:
Inclusion Criteria:

        Parkinson's disease

          -  Male or female with age over 40 years

          -  Clinical diagnosis of Parkinson's disease

          -  Ability to give informed consent

        Essential tremor

          -  Male or female with age over 40 years

          -  Clinical diagnosis of Essential tremor

          -  Ability to give informed consent

        Healthy volunteers

          -  Male or female with age over 40 years

          -  No any symptoms or sign suggesting Parkinson's disease or essential tremor

          -  Ability to give informed consent

        Exclusion Criteria:

        Parkinson's disease and essential tremor

          -  Current pregnancy and breast feeding

          -  Current or past medical history of cardiac and neuropsychiatric disease

          -  Clinical evidence of dementia

          -  Inability to hold antiparkinsonian medication

          -  History of surgical therapy for tremor

          -  Severe or unstable medical or psychiatric condition

          -  Medication affecting CNS in last 6 months(e.g. CNS stimulants, sympathomimetics)

          -  Prior participation in other research protocol within 30 days

        Healthy volunteers

          -  Current pregnancy and breast feeding

          -  Current or past medical history of cardiac and neuropsychiatric disease

          -  Severe or unstable medical or psychiatric condition

          -  Drug abuse or medication affecting CNS (e.g. CNS stimulants, sympathomimetics) within
             6 months

          -  Prior participation in other research protocol within 30 days
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment