araag2/NLI4PR huggingface dataset:
Clinical trial: Hypertrophic Cardiomyopathy Pilot Study (NCT02806479)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed HCM

          -  Documented history of sustained ventricular tachyarrhythmia or resuscitated sudden
             cardiac arrest

          -  Maximal left ventricular wall thickness of > 30mm

          -  Extensive fibrosis on cardiac MRI (>15% of total myocardial volume)

          -  >7.5%/5-year risk of sudden cardiac death as determined by HCM risk-SCD

        Exclusion Criteria:

          -  age < 18 years

          -  Pregnancy

          -  Atrial Fibrillation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: Maintenance Treatment for Children With Constipation (NCT01566409)

Eligibility criteria:
Inclusion Criteria:

          -  Children between 2 and 16 years and referral to our out patient clinic with either
             constipation or fecal incontinence.

          -  Patients must fulfill the Rome III criteria of constipation, which mean they must have
             at least 2 of the following characteristics: fewer than 3 bowel movements weekly, more
             than 1 episode of fecal incontinence weekly, large stools in the rectum by digital
             rectal examination or palpable on abdominal examination, occasional passing of large
             stools, display of retentive posturing and withholding behavior, and painful
             defecation.

        Exclusion Criteria:

          -  Children with known organic causes of constipation, including Hirsprung disease,
             spinal and anal congenital abnormalities, previous surgery on the colon, inflammatory
             bowel disease, allergy and metabolic or endocrine diseases.

          -  Children receiving drugs known to affect bowel function during a 2 month period before
             initiation.

          -  The healthy control group consists of children with no history of constipation (Rome
             III), urinary incontinence, urinary tract infections, fecal incontinence, laxative use
             or any other disease affecting the digestive system.

          -  Children receiving medications known to affect bowel function are excluded from the
             study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 16 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy of Miswak in Oral Hygiene Maintenance (NCT04561960)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy adults

          -  Able to perform their own oral hygiene

          -  Dental students

        Exclusion Criteria:

          -  Active Dental Caries

          -  Uncontrolled chronic medical conditions

          -  History of drug and/or treatment that reduces salivary flow

          -  Currently undergoing orthodontic treatment

          -  Missing index teeth #16, #12, #24, #36, #32, #44
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 25 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: RCT for Women With a Persisting Pregnancy of Unknown Location (NCT01800162)

Eligibility criteria:
Inclusion Criteria:

          1. Female with a persisting pregnancy of unknown location:

               1. A pregnancy of unknown location is defined as a women with a positive pregnancy
                  test but no definitive signs of pregnancy in the uterus or adnexa on ultrasound
                  imaging (Ultrasound must be performed within 7 days prior to randomization)

               2. Persistence of hCG is defined as 3 serial hCG values over 4-14 days or 2 serial
                  hCG values over 7-14 days, showing less than 30% rise, or less than 30% fall
                  between the first and last value. (This abnormal pattern of serial hCG confirms
                  that the gestation is nonviable.)

          2. Patient is hemodynamically stable, hemoglobin greater than 10 mg/dL,

          3. Greater than or 18 years of age

        Exclusion Criteria:

          1. Hemodynamically unstable in need of acute treatment

          2. Most recent hCG greater than 5000 IU/mL

          3. Patient obtaining care in relation to a recently completed pregnancy (delivery,
             spontaneous or elective abortion),

          4. Diagnosis of gestational trophoblastic disease,

          5. Subject unwilling or unable to comply with study procedures,

          6. Presence of clinical contraindications for treatment with methotrexate (ACOG
             guidelines, Appendix B),

          7. Prior medical or surgical management of this gestation.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Estrogen on Mental and Social Functioning in Girls With Turner's Syndrome (NCT00004274)

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

          -  Girls aged 8 and 12 years with Turner's syndrome-compatible karyotype

          -  Age-matched girls without Turner's syndrome entered as controls

          -  Concurrent registration on Thomas Jefferson University growth study required of
             subjects with Turner's syndrome
Female
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Magnetic Resonance Angiography vs Ultrasonography in Systemic Large vEssel vasculitiS (NCT02042092)

Eligibility criteria:
Inclusion Criteria:

          1. Patients >18 years

          2. Diagnosis of large vessel vasculitis based on Ultrasonographic and/or Computed
             Tomography Angiography and/or Magnetic Resonance Angiography findings or biopsies of
             the temporal arteries

          3. Fulfill the classification criteria for Giant Cell Arteritis /Takayasu Arteritis

        Exclusion Criteria:

          1. Patients <18 years

          2. Moderate to severe kidney failure

          3. Known allergic reactions to contrast agents

          4. Inability to give informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Varying Testosterone Levels on Insulin Sensitivity in Normal and IHH Men (NCT00470990)

Eligibility criteria:
Inclusion Criteria:

        Healthy men:

        Good general health,

          -  Normotensive,

          -  Normal testosterone levels,

          -  No medications known to influence glucose homeostasis or testosterone levels

        IHH men:

          -  Good general health;

          -  Normal thyroid, adrenal, and GH axes;

          -  Normal prolactin levels;

          -  No abnormalities on imaging of the hypothalamic-pituitary region;

          -  No medications known to influence glucose homeostasis;

          -  Must have been off hormone therapy for a suitable washout period depending on the type
             of prior androgen replacement
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Strategies to Treat Osteoporosis Following a Fragility Fracture (NCT00512499)

Eligibility criteria:
Inclusion Criteria:

          -  Over 50 years of age

          -  Fragility fracture

          -  Consulting an orthopedic surgeon at the CHUS for treatment of the fracture

        Exclusion Criteria:

          -  No Primary Care Practitioner

          -  Severe co-morbidity requiring specialized care

          -  Failure to consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 95 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Quantum Natural Family Planning Pilot (NCT03908697)

Eligibility criteria:
Inclusion Criteria:

          -  • Menstrual cycle ranging between 21-42 days

               -  At least 3 cycles after cessation of breastfeeding

        Exclusion Criteria:

          -  • Not currently on medications that affect ovulation and 3 months prior

               -  Not currently pregnant or breastfeeding

               -  No known fertility problems

               -  Not planning on achieving pregnancy during the 3 menstrual cycles of the study
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 42 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of the Reproducibility Inter-observer of the Ultrasound Anomalies of the Salivary Glands in Sjogren's Disease (NCT02358213)

Eligibility criteria:
Inclusion Criteria:

          -  Men and women from 18 to 80 years old

          -  Patients recruited during the multidisciplinary consultation of Sjogren's Disease,
             filling the criteria of Sjogren's Disease or patients having a salivary recidivate
             pathology and selected players on the basis of their voluntary service to benefit from
             an ultrasound of the main salivary glands

          -  The patients will have to be capable of adhering to the protocol of study and of
             having understood it.

          -  The patients will have to be capable of giving a signed informed consent, the latter
             being obtained before the inclusion

        Exclusion Criteria:

          -  Not cooperative patient and having refused to sign the informed consent.

          -  Patient incapable to understand the protocol, under guardianship or under
             guardianship.

          -  Unaffiliated patients to the Social Security.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment