araag2/NLI4PR huggingface dataset:
Clinical trial: Effect of Muscle Strength on Hamstring Flexibility in Children With Duchenne Muscular Dystrophy (NCT03589573)

Eligibility criteria:
Inclusion Criteria:

          -  Getting a Duchenne Muscular Dystrophy diagnosis,

          -  Being in ambulatuar phases and independently climbing four stairs

          -  To be cooperate to physioterapist's directions

        Exclusion Criteria:

          -  Having severe contracture in the lower extremity

          -  Having undergone surgery in the past 6 months
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 18 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of Telerehabilitation of Patients With Duchenne Muscular Dystrophy (NCT04782440)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Duchenne muscular dystrophy

        Exclusion Criteria:

          -  Patients without the ability of independent ambulation
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 18 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Can Ibuprofen Delay Ovulation in Natural Cycle-IVF? (NCT02571543)

Eligibility criteria:
Inclusion Criteria:

          -  Indication for NC-IVF

          -  Wish for NC-IVF

          -  Menstruation every 26-32 days

          -  Accessibility of both ovaries for a follicle aspiration

          -  18-42 years of age

          -  Written informed consent

          -  Indication for IUI or TSI

          -  Wish for IUI or TSI

        Exclusion Criteria

          -  <18 and >42 years of age

          -  Gastro-intestinal diseases

          -  Known Ibuprofen Intolerance
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 42 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of People With Gastrointestinal Disease (NCT01639924)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Known or suspected gastrointestinal disorders.

          -  Patients greater than or equal to 18 years of age capable of providing informed
             consent.

          -  Existence of a referring community physician who would be able to manage care outside
             of the NIH.

        EXCLUSION CRITERIA:

          -  Significant medical illnesses that the investigators feel may interfere with potential
             evaluations.

          -  Any medical, psychiatric, or social conditions which, in the opinion of the
             investigators, would make participation in this protocol not in the best interest of
             the patient.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Wearable Pulsed Electromagnetic Fields Device in Knee Osteoarthritis: Double Blinded, Randomized Clinical Trial (NCT01877278)

Eligibility criteria:
Inclusion Criteria:

          -  a diagnosis of primary OA of the knee according to the ACR criteria, including
             radiologic evidence of OA

          -  age >40 years

          -  symptomatic disease for at least 6 months prior to enrollment

          -  persistent pain despite receiving the maximum tolerated doses of conventional medical
             therapy, including acetaminophen (4 gm/day) and/or a nonsteroidal antiinflammatory
             drug (NSAID), with persistent pain defined as a minimum mean score of 25 mm on the
             visual analog scales (VAS) for global pain (0-100-mm range for each) daily pain during
             the month prior to study enrollment

          -  ability to attend followup appointments

        Exclusion Criteria:

          -  secondary causes of OA

          -  local or systemic infection

          -  diabetes mellitus

          -  systemic arthritis

          -  allergy to anesthetic agent or contrast material

          -  coagulopathy

          -  anticoagulant therapy

          -  had previous IA steroid injection

          -  avascular necrosis of bone

          -  patients who are on specific OA pharmacological therapy (NSAIDS, opioids) for more
             than 2 weeks prior enrollment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Determination of a Questionnaire After Treatment With Pantoprazole at Full Dose and Half Dose in Adult Patients With Symptoms of Acid Reflux (Gastroesophageal Reflux Disease) (BY1023/UK-506) (NCT00261339)

Eligibility criteria:
Main inclusion criteria:

          -  Written informed consent

          -  Outpatients of at least 18 years of age

          -  GERD

          -  Patients with symptoms of GERD

        Main exclusion criteria:

          -  Signs, indicating other gastrointestinal diseases

          -  Other concomitant diseases

          -  Special restrictions for female patients

          -  Previous medication

          -  Concomitant medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Iron Reduction by Phlebotomy for Type 2 Diabetes (NCT02468037)

Eligibility criteria:
Inclusion Criteria:

          -  Age 35-65

          -  Prediabetes, or diabetes relatively well-controlled (Hemoglobin A1c [HbA1c] ≤ 8.0%)
             with a single oral agent as defined by oral glucose tolerance testing (OGTT) using
             criteria of the American Diabetes Association.

          -  Serum ferritin values in the upper 50% of the normal range, 110-400 ng/mL for males,
             or 80-240 for females.

        Exclusion Criteria:

          -  hereditary hemochromatosis;

          -  cancer (except cases currently with no evidence of disease);

          -  serum creatinine >1.5;

          -  anemia (Hgb < lower limit of normal);

          -  chronic inflammatory conditions (rheumatologic conditions such as rheumatoid arthritis
             or giant cell arteritis, or chronic infections such as hepatitis B or C) that could
             affect ferritin;

          -  erythrocyte sedimentation rate or C-reactive protein>1.5 times the upper limit of
             normal (UNL);

          -  serum transaminases 2 x UNL;

          -  hemophilia,

          -  warfarin therapy,

          -  history of GI bleeding;

          -  current glucocorticoid therapy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Exploration of Patient Ethics and Communication Excellence (PEACE) Rounds (NCT03874676)

Eligibility criteria:
Inclusion Criteria:

          1. An employee of AdventHealth (AH), or a physician with privileges there, who has
             participated in PEACE Rounds at AdventHealth.

          2. Over the age of 18

          3. Able to provide informed consent

          4. Must speak and understand English

        Exclusion Criteria:

        1. Discernable cognitive impairment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Hearing Study: Sensitivity to Features of Speech Sounds (NCT03666676)

Eligibility criteria:
Inclusion Criteria:

          -  Normal hearing, mild or moderate symmetric sensorineural hearing loss.

        Exclusion Criteria:

          -  Asymmetric hearing thresholds (more than 15 decibels (dB) threshold difference between
             the two ears at any frequency up to 4 kHz).

          -  Severe hearing loss (greater than 60 dB hearing thresholds at any frequency up to 4
             kHz).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction
Clinical trial: Cohort of Patients With Rare Iron Overloads Excluding C282Y Homozygosity (NCT02619955)

Eligibility criteria:
Inclusion Criteria:

          -  Biological profile suggestive of hepcidin deficiency:

               -  increase of transferrin saturation coefficient (> 50 %) verified on at least 2
                  times, and calculated from the transferrinemia.

               -  Proved hepatic iron overload: by the dosage of the iron hepatic concentration
                  either on block hepatic biopsic, or by MRI according to the method of
                  quantification of the iron validated overload (by adopting a threshold of 100
                  µmol /g)

               -  Patient's written consent for examination of genetic characteristics for
                  diagnosis and collection development for genetic and not genetic research within
                  the framework of an abnormality of the iron metabolism

               -  Patient written inform consent.

        Exclusion Criteria:

          -  HFE hemochromatosis: homozygosity C282Y/C282Y

          -  Treatment with iterative phlebotomy

          -  Hematologic diseases with dyserythropoiesis and/or repeated transfusions

          -  Haptoglobin low, below normal directing towards the diagnosis of chronic hemolysis,
             myelodysplasia

          -  Prolonged oral or parenteral iron supplementation

          -  Current or past excessive regular drinking

          -  Patient minor or under legal protection measure
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction