araag2/NLI4PR huggingface dataset:
Clinical trial: Multicenter Study of Nontuberculous Mycobacteria in Cystic Fibrosis Patients (NCT00004296)

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

        Patients over age 10 with cystic fibrosis documented as follows:

          -  Pilocarpine sweat chloride test at least 60 mEq/L OR

          -  Genotyping or transepithelial potential difference AND

          -  Clinical symptoms of suppurative respiratory disease or pancreatic insufficiency

        Able to produce at least 3 sputum samples

          -  Bronchoscopy specimens acceptable

          -  Throat/nasal specimens not acceptable

        No Pseudomonas cepacia colonization
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Biomarkers Serum Collection Methodology Pilot Study (NCT01318707)

Eligibility criteria:
Inclusion Criteria:

          -  Severe Hemophilia A

        Exclusion Criteria:

          -  If they are not diagnosed with severe hemophilia A.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Divergence of Blood Pressure By Race in Adolescent Girls (NCT00005470)

Eligibility criteria:
No eligibility criteria
Male
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy and Tolerability of an Intra-Nasal Testosterone Product (NCT00975650)

Eligibility criteria:
Inclusion Criteria:

          -  Men with primary or secondary hypogonadism and a serum morning (0900 h ± 30 minutes)
             testosterone levels >100 ng/dl and ≤ 300 ng/dL.

          -  Normal Otolaryngological nasal endoscopy examination.

          -  Normal prostate examination (no palpable prostatic mass), and serum PSA ≤ 4.0 ng/mL.

        Exclusion Criteria:

          -  Current treatment with other androgens (i.e. DHEA), anabolic steroids or other sex
             hormones

          -  Treatment with Estrogens, GnRH antagonists, or Growth Hormone within previous 12
             months

          -  History of nasal surgery, specifically turbinoplasty, septoplasty, rhinoplasty, or
             sinus surgery.

          -  History of nasal disorders (e.g. polyposis, recurrent epistaxis ( > 1 nose bleed per
             month, abuse of nasal decongestants) or sleep apnea.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluating Face-Recognition Technology in Syndrome Diagnosis (NCT04709965)

Eligibility criteria:
Inclusion Criteria:

        - Patients attending routine genetic clinic/paediatric clinic appointments for diagnosis of
        a multiple anomaly syndrome where distinctive facial features form part of their presenting
        pattern.

        OR:

        - Biochemically or genetically confirmed diagnosis of inborn disorder of metabolism where
        no well described dysmorphic facial features are known to be associated with disorder

        Exclusion Criteria:

          -  Patients under 8 months of age where face-recognition technology has not been shown to
             be effective.

          -  Patients who decline clinical photography as part of standard care.

          -  Patients who do not wish to consent to participation in the study even though they
             consent to photos being taken for standard care.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Months old.


Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Minimal-Massive Intervention in Elderly Patients With Dysphagia (NCT02396992)

Eligibility criteria:
Inclusion Criteria:

          -  Older patients (≥70 years) admitted to Unit 5 and 8 of Hospital de Mataró.

          -  With OD diagnosed by the V-VST.

          -  Patients that have signed the informed consent form.

          -  Patients without any exclusion criteria.

        Exclusion Criteria:

          -  Patients not able to comply with the protocol.

          -  Patients currently participating in any clinical trial or during the 4 last weeks.

          -  Patients with severe dementia or inability to communicate (GDS ≥ 6).

          -  Patients of the Intensive Care Unit.

          -  Patients with low functionality (Barthel pre-admission ≤ 40).

          -  Patients with high mortality risk (Walter score > 6).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 70 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism (NCT02282150)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with adrenal insufficiency due to hypopituitarism

          -  In steady twice or thrice daily (10-40 mg) hydrocortisone replacement treatment

          -  Written informed consent

          -  For women: Use of reliable methods of contraception in clinical trials in accordance
             with the definition by the Danish Health and Medicines Authority; intrauterine devices
             or hormonal methods (oral contraceptives, contraceptive implants, transdermal patches,
             hormonal vaginal devices or injections with prolonged release).

        Exclusion Criteria:

          -  Pregnancy

          -  Breast feeding

          -  Acromegaly

          -  Cushing's Disease

          -  Diabetes Mellitus

          -  Other major confounding disease

          -  Known or expected hypersensitivity to any of the excipients

          -  Lack of compliance (attendance and medication)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pharmacokinetics of Immediate-Release vs. Delayed-Release Omeprazole in Gastroparesis (NCT00492622)

Eligibility criteria:
Inclusion Criteria:

          -  Symptoms of heartburn >2 days per week off antireflux therapy, defined by "a burning
             feeling rising from the stomach or lower chest up towards the neck"

          -  Symptoms of gastroparesis >1 month in duration, defined by nausea, vomiting, bloating,
             dyspepsia, early satiety, or effortless regurgitation.

          -  Prior abnormal 4-hour gastric emptying scan within the past 3 years

        Exclusion Criteria:

          -  History of esophageal or gastric surgery

          -  Severe gastroparesis with any of the following: vomiting with dehydration requiring IV
             hydration, hospitalization, weight loss >10 % pre-illness weight, requiring feeding
             jejunostomy tubes

          -  Presence of gastric electrical stimulator

          -  Symptoms of retching with vomiting more than 2 days per week

          -  Diagnosis of diabetes

          -  Disorders of small bowel motility (such as pseudo-obstruction or dumping syndrome)

          -  Disorders of small bowel absorption

          -  Diagnosis of gastric outlet, small bowel or colon mechanical obstruction

          -  Diagnosis of acid hypersecretory syndrome

          -  Disorders affecting proton pump inhibitor metabolism (such as liver failure)

          -  Known allergy or side effects to proton pump inhibitor

          -  Non-ambulatory patients: bed-ridden, nursing home resident, etc.

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Transcranial Direct Current Stimulation of the Motor Cortex in Essential Tremor (NCT03952117)

Eligibility criteria:
Inclusion Criteria:

        - Patients who fulfil the 2017 Movement society concusses statement criteria for essential
        tremor

        Exclusion Criteria:

          -  Isolated focal tremor (voice, head)

          -  Orthostatic tremor with a frequency of more than 12 Hz

          -  Task and position specific tremor

          -  Sudden onset and stepwise deterioration of tremor

          -  History of substance abuse or dependence in the past

          -  Co-morbid medical conditions capable of producing or enhancing tremors

          -  Use of a medication with potential effect on tremor

          -  History of neurological disorders, brain tumors, brain surgery or abnormal
             neurological examination

          -  Epileptic disorders

          -  Cardiac pacemakers

          -  Metallic hardware in the head or scalp (surgical clips)

          -  Eczema or skin abrasion at the intended site of stimulation

          -  Currently pregnant or plan for pregnancy in the next 6 months

          -  Patients with prior experience with tDCS

          -  Major psychosocial problems or medical problems rendering informed consent impossible
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Circulating Microparticles in Giant Cell Arteritis (NCT02333708)

Eligibility criteria:
For GCA group:

        Inclusion Criteria:

          -  Men and women ≥ 18 years of age Patient affiliated to social security regimen

          -  Informed and having signed the consent form to take part in the study.

          -  Diagnosis of GCA, meeting at least 3 of the following 5 American College of
             Rheumatology (ACR) criteria for the diagnosis of GCA, including inflammatory syndrome
             and having

               -  Either temporal artery biopsy showing characteristic GCA abnormality

               -  Or inflammatory arteritis on imaging examination

        Exclusion Criteria:

          -  Persons under protection of the court or guardianship

          -  Inability to understand or to follow study procedures

          -  Dementia

          -  cancer diagnosed within the previous 5 years (except for non-melanoma skin cancer or
             in situ carcinoma of the cervix)non-contributory or inconclusive temporal artery
             biopsy

          -  Any conditions that might interfere with MPs level: diabetes, recent endo-arterial
             gesture, current treatment with corticosteroids.

          -  Participation in another ongoing clinical trial Current anticoagulant therapy

          -  Active infectious disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment