araag2/NLI4PR huggingface dataset:
Clinical trial: Cyclosporine A to Treat Hypertrophic Cardiomyopathy (HCM) (NCT00001965)

Eligibility criteria:
Patients of either gender, aged 18-75 years, with HCM caused by sarcomeric gene mutations
        determined by existing protocols.

        LV wall thickness of greater than or equal to 20 mm measured in any LV segment by MRI.

        Severe symptoms refractory to medical treatment (New York Heart Association functional
        class III or IV).

        No LV outflow tract obstruction at rest greater than 30 mm Hg as determined by cardiac
        catheterization.

        No coronary artery disease (greater than 50% arterial luminal narrowing of a major
        epicardial vessel).

        No chronic atrial fibrillation.

        No bleeding disorder (PTT greater than 35 sec, pro time greater than 14 sec, platelet count
        less than 154 k/mm(3).

        No anemia (Hb less than 12.7 g/dl in males and less than 11.0 g/dl in females).

        No renal impairment (serum creatinine greater than 1.3 mg/dl).

        No hepatitis B or C; nor unexplained abnormal LFTs.

        No inability to estimate LV wall thickness.

        No positive urine pregnancy test.

        No pregnant or lactating female patients.

        No concurrent use of immunosuppressives or steroids.

        No diabetes mellitus.

        No history of malignancy other than skin tumors (squamous and basal cell) in the last 5
        years.

        No condition that excludes the patient from undergoing an MRI test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: PREventative Study Against URate-Lowering Drug-Induced Gout Exacerbations (PRE-SURGE 2) (NCT00958438)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female 18 to 80 years of age;

          -  Previously met the preliminary criteria of the American Rheumatism Association (ARA)
             for the classification of the acute arthritis of primary gout;

          -  At least 2 gout flares in the year prior to the screening visit;

          -  Serum uric acid greater than or equal to 7.5 mg/dL at the screening visit.

        Exclusion Criteria:

          -  Acute gout flare within 2 weeks of the screening visit or during screening;

          -  Persistent chronic or active infections;

          -  History of an allergic reaction to allopurinol;

          -  History or presence of cancer within 5 years of the screening visit;

          -  Previous exposure to Rilonacept;

          -  Use of allopurinol, benzbromarone, febuxostat, probenecid or sulfinpyrazone within 3
             months prior to the screening visit.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris (NCT02828163)

Eligibility criteria:
Inclusion Criteria:

          -  Pemphigus vulgaris patients having bilateral erosions in the buccal mucosa.

        Exclusion Criteria:

          -  Pemphigus vulgaris patients who do not have oral erosions.

          -  Pemphigus vulgaris patients who have received intralesional steroid injection in their
             buccal mucosa.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparison of Two Different Splints in the Treatment of Lateral Epicondylitis (NCT04773249)

Eligibility criteria:
Inclusion Criteria:

          -  Applying to Dokuz Eylül University Medical Faculty Physical Medicine and
             Rehabilitation Department outpatient clinic

          -  Having pain in the elbow for less than 12 weeks and having no similar attack history
             for 1 year

          -  Diagnosing lateral epicondylitis with clinical and ultrasonographic evaluation

          -  Having pain of at least 3 in their VAS scores

          -  Agreeing to participate in the study

        Exclusion Criteria:

          -  Having elbow pain for more than 12 weeks

          -  Having signs of lateral epicondylitis in the other extremity

          -  Having a history of injection for lateral epicondylitis

          -  In the last 3 months, who had physical therapy for lateral epicondylitis

          -  Having a history of elbow surgery and fracture in the elbow area.

          -  Having muscle weakness in the upper extremity due to cervical radiculopathy and/or
             entrapment neuropathy

          -  Having malignancy or neurological, rheumatological, and psychiatric disease
             comorbidities

          -  Pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparative Study of Epigastric Pain Syndrome and Postprandial Distress Syndrome (NCT00673972)

Eligibility criteria:
Inclusion Criteria:

          -  aged greater than 20 years

          -  fulfill Rome III diagnostic criteria

        Exclusion Criteria:

          -  children and teenagers aged less than 20 years

          -  Organic lesions such as ulcers, tumors, bleeding, vasculopathy or esophagitis as
             demonstrated on upper endoscopy

          -  concurrent illness with malignancy, diabetes mellitus, liver cirrhosis, renal failure
             or porphyria

          -  diagnosis of organic disease for dyspeptic symptoms by treating physicians

          -  history of abdominal surgery

          -  concurrent user of aspirin and NSAID

          -  history of allergy or severe side effects to lansoparzole

          -  pregnant or lactating women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Beacon BNX™ Endoscopic Ultrasound (EUS)-Needle vs SharkCore™ Needle (NCT02872831)

Eligibility criteria:
Inclusion Criteria:

          -  Eligible patients will include anyone >18 years old that presents to the participating
             clinical institutions and requires an endosonographic evaluation for the presence of a
             solid-appearing mass lesion amenable to EUS access, and no contraindication to FNA as
             determined by standard clinical care

        Exclusion Criteria:

          1. Refusal to participate in the study

          2. Solid-appearing mass lesion that in not amenable to EUS guided needle access for
             tissue acquisition

          3. Patients with incomplete medical records

          4. Pregnant patients

          5. Prisoners

          6. INR > 1.5

          7. Platelets < 50,000
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: World Bleeding Disorders Registry (NCT03327779)

Eligibility criteria:
Inclusion Criteria:

          -  Patients of participating Hemophilia Treatment Centres with Hemophilia A or B

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of Structured Information and Individually Adapted Exercise on Levels of Physical Activity Measured by Accelerometer in Patients With Knee or Hip Osteoarthritis (NCT02022566)

Eligibility criteria:
Inclusion Criteria:

          1. Age between 18 and 75 years old.

          2. Patients with clinically verified OA, coming to see a physical therapist for the
             Supported self-management of osteoarthritis program.

        Exclusion Criteria:

          1. Other serious disorders causing hip or knee pain (e.g. tumor, rheumatic arthritis,
             sequel hip fracture).

          2. Other symptoms more aggravating than the OA problem (e.g. chronic pain, fibromyalgia,
             cardio-respiratory dysfunction, spinal condition).

          3. Total joint replacement surgery within the past 12 months.

          4. Other surgery of knee or hip within the past 3 months.

          5. Unable to read and understand Swedish and follow verbal and visual instructions.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Nutrition and Soccer for Pediatric Overweight and Obesity (NCT00365651)

Eligibility criteria:
Inclusion Criteria:

          -  obese or overweight 4th grade public school student in Starkville

        Exclusion Criteria:

          -  unable to run or physical disease or disability
Female
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Omepral® Tablets Special Clinical Experience Investigation in Patients With Erosive Esophagitis (NCT00859287)

Eligibility criteria:
Inclusion Criteria:

          -  Patients newly diagnosed as erosive esophagitis or history of erosive esophagitis
             confirmed by endoscopy.

          -  Patients who answered questionnaires of quality of life (QOLRAD-J), symptom severity
             and frequency and treatment satisfaction.

          -  During the past 1 week , patients who have either two days or more with heartburn or
             acid taste in the mouth of any severity

        Exclusion Criteria:

          -  Patients receiving treatment with proton pump inhibitors, which make stomach acid
             decreased during the last 4 weeks prior to enrolment.

          -  Patients who cannot answer questionnaires of quality of life (QOLRAD-J), symptom
             severity and frequency and treatment satisfaction.

          -  Patients included previously in this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction