araag2/NLI4PR huggingface dataset:
Clinical trial: Efficacy of Radial Shockwave Therapy for Treatment of Pain in Knee Osteoarthritis (NCT02197962)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical and radiological diagnosis of primary knee diagnosis.

          -  Pain intensity: Visual Analog Scale (VAS) ≥ 6;

          -  One of more failures with conventional treatment (drugs, Non-Steroidal
             Anti-inflammatory Drugs - NSAD, physiotherapy, stretching, acupuncture, orthosis and
             others);

          -  Age over 60 years;

          -  No use of corticosteroids in the prior 48 hours;

          -  No major osteoarthritis events in other joints of lower limbs (waist and ankle) and
             lower back;

          -  No clinical evidence of related neuropathy, including radiculopathy and peripheral
             neuropathy;

          -  Absence of systemic inflammatory disease (Rheumatoid arthritis, Reiter, ankylosing
             spondylitis, generalized polyarthritis, cancer);

          -  Absence of infection or cancer at the application site;

          -  Absence of related endocrine and metabolic diseases;

          -  Absence of fibromyalgia, diagnosed after the American College of Rheumatology, 1999;

          -  Absence of severe blood dyscrasias;

          -  Absence of severe psychiatric disturbances that requires psychiatric assessment;

          -  Availability to comply with the clinic visits and follow up evaluations along the
             treatment

        Exclusion Criteria:

          -  Patients who withdraw the informed consent form at any time
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Assessment of Day-night Secretion of Progesterone and LH Across Puberty (NCT02155933)

Eligibility criteria:
Inclusion Criteria:

          -  Early and late pubertal girls with normal androgens

          -  Early and late pubertal girls with hyperandrogenemia

          -  All subjects will be girls from pre-puberty (Stage 1 breast development and pubic hair
             growth but at least 7 years old) to 7 years post menarche.

        Exclusion Criteria:

          -  Pregnancy

          -  Inability to comprehend what will be done during the study or why it will be done

          -  Hemoglobin <11.5 g/dL for non-African American subjects; Hemoglobin < 11.0 g/dL for
             African American subjects

          -  Persistently abnormal sodium, potassium, or bicarbonate (i.e., confirmed on repeat)

          -  Persistently elevated creatinine, hepatic transaminases, or alkaline phosphatase
             (i.e., confirmed on repeat)

          -  Total bilirubin > 1.5 times upper limit of normal (i.e., confirmed on repeat)

          -  Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected
             congestive heart failure; asthma requiring intermittent systemic corticosteroids;
             etc.)

          -  Untreated hypo- or hyperthyroidism (reflected by persistently abnormal TSH values)

          -  Total testosterone > 200 ng/dl

          -  Basal (follicular) 17-OHP > 200 ng/ml (in girls without a previous diagnosis of
             congenital adrenal hyperplasia)

          -  DHEA-S > 800 mcg/dl

          -  Elevation of prolactin > 2 times upper limit of normal

          -  Weight less than 25 kg
Female
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Growth Hormone (GH) Deficiency & Insulin Like Growth Factor 1 (IGF-I)/ Insulin Like Growth Factor Binding Protein 3 (IGFBP-3) Ratio (NCT02424240)

Eligibility criteria:
Inclusion Criteria:

          -  children presented to Jordan Univeristy Hospital (JUH) outpatient endocrinology clinic
             for the evaluation of short stature (SS)

        Exclusion Criteria:

        (i) their parents could not provide written consent for them; (ii) they were lost to follow
        up; (iii) they could not perform clonidine stimulation tests (CST) or insulin tolerance
        test (ITT) due to a medical contraindication (e.g. cardiac disorder, seizure disorder);
        (iv) they had received GH therapy in the past; (v) they were known to have pituitary
        diseases, hypothyroidism, hypogonadism or discovered to have panhypopituitarism or (vi)
        they have malnutrition, diabetes mellitus, liver disease, or other chronic illnesses.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 4 Years old.
Subject must be at most 16 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Novel Therapies for Essential Tremor (NCT00018564)

Eligibility criteria:
1. Diagnosis of essential tremor.

          2. Tremor rating scale score 3 or one or both upper extremities

          3. Unsatisfactory response to primidone or to propanolol

          4. Not taking tremor-inducing drug

          5. Able to comply with visits
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Gastrectomy and Anastomosis on Diabetes and Hypertension in Early Gastric Cancer Patients (NCT01643811)

Eligibility criteria:
Inclusion Criteria:

          -  Histologically proven primary gastric adenocarcinoma

          -  clinical stage Ia or Ib examined with endoscopy, endoscopic ultrasound, and computed
             tomography

          -  aged 20-80 year old,

          -  performance status (PS) of 0 or 1 on Eastern Cooperative Oncology Group (ECOG) scale

          -  diagnosed as diabetes or hypertension

          -  patients planning to undergo gastrectomy or endoscopic submucosal dissection

          -  written informed consent

        Exclusion Criteria:

          -  having high risk for operation such as severe heart disease, severe respiratory
             disease

          -  pregnant

          -  previous abdominal surgery or radiation therapy

          -  proven more advanced disease than pathological stage II requiring adjuvant
             chemotherapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: The Dynamic Interplay Between Bleeding Phenotype and Baseline Factor Level in Moderate and Mild Hemophilia A and B (NCT03623295)

Eligibility criteria:
Inclusion Criteria:

          -  Moderate or mild hemophilia A (FVIII:C 0.02-0.35 IU/mL) or hemophilia B (FIX:C
             0.02-0.35 IU/mL)

          -  Age from 12 up to and including 55 years

        Exclusion Criteria:

          -  Other clotting disorder

          -  Participation in another trial with an investigational product

          -  Comorbidity affecting the musculoskeletal status

          -  Clinically relevant inhibitor status at present or in the past

          -  Hemophilia B Leyden

          -  Use of anticoagulants
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparison of Estrogen-progestin Therapy in Continuous Regimen Versus Combination Estrogen-progestin Therapy in Continuous Regimen Plus Levonorgestrel-releasing Intrauterine System (LNG-IUS) (NCT02556411)

Eligibility criteria:
Inclusion Criteria:

          -  Women affected by adenomyosis with pelvic pain > 4;

          -  Negative Pap Smear test

        Exclusion Criteria:

          -  Pregnancy or research of pregnancy

          -  Refusal or inability to sign informed consent

          -  Severe underlying comorbidities (hepatic, oncological)

          -  Pelvic inflammatory disease

          -  Other cervical or uterine pathologies

          -  Deep venous thromboembolism

          -  Hormonal therapy contraindications

          -  Smoke
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Staging Procedures to Diagnose Malignant Pleural Mesothelioma (NCT02648763)

Eligibility criteria:
Inclusion Criteria:

          -  Subject provides informed consent

          -  Subject is >18 years of age

          -  Subject is deemed competent for making medical decisions

          -  Subject is scheduled to undergo a staging pleuroscopy

          -  Subject is a surgical candidate

          -  A negative pregnancy test is required in women of child-bearing potential, as standard
             of care.

        Exclusion Criteria:

          -  Subject is <18 years old.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Early Diagnosis of Alzheimer-like Dementia: Benefit of MRI and PET Imaging (NCT01815112)

Eligibility criteria:
Inclusion Criteria:

          -  Age: over 65

          -  Participants (or representatives) gave their written informed consent

          -  Dementia diagnosed according to Diagnostic and Statistical Manual of Mental Disorders
             (DSM IV) criteria

          -  For Alzheimer arm: probable Alzheimer based disease according to NINCDS-ADRDA
             (National Institute of Neurological and Communicative Disorders and Stroke and the
             Alzheimer's Disease and Related Disorders Association ) criteria

          -  For vascular dementia: diagnosis based on NINDS-AIREN (National Institute of
             Neurological Disorders and Stroke and Association Internationale pour la Recherche et
             l'Enseignement en Neurosciences) criteria

          -  For MCI: diagnosis based on Petersen index

        Exclusion Criteria:

          -  Claustrophobia

          -  Diabetes

          -  Cardiovascular disease

          -  Glycemia over 1.3 g/L

          -  Lumbar puncture within one week before MRI examination

          -  Non MR-compatible implant

          -  Suspected brain metastases

          -  No informed consent signature
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Multistability: Perception is Inspired by Noise (NCT03723044)

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent

          -  Medical examination carried out before the participation in the research

          -  Age between 18 and 55 years

          -  Minimum level of studies

          -  Obligation to join the social security system

          -  normal or corrected vision normal

        Exclusion Criteria:

          -  Subject included in another clinical and / or therapeutic experimentation in progress

          -  Major vision disorder

          -  Past or current neurological or neuropsychiatric pathologies

          -  History of cranial trauma with loss of consciousness.

          -  Medication treatments likely to modulate brain activity: benzodiazepine,
             antidepressants, neuroleptics, lithium, etc.

          -  Diabetes, cardiac pathology, immunodeficiency.

          -  Medication treatments likely to modulate the activity of the cardiovascular system.

          -  History of abuse or recent ingestion of alcohol, hard drugs or doping products.

          -  Consumption of more than 15 cigarettes per day

          -  Subject deprived of liberty by a judicial or administrative decision (L1121-6 CSP)

          -  Major subject subject to a legal protection measure or unable to express their consent
             (L1121-8 CSP)

          -  Pregnant, parturient and nursing mothers (L1121-5)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? Contradiction