araag2/NLI4PR huggingface dataset:
Clinical trial: Confocal Endoscopic Microscopy for Detection of Early Stage Gastric Cancer in Subjects With Hereditary Diffuse Gastric Cancer Syndrome (NCT03648879)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Patients with Cadherin-1 (CDH1) germline mutation known to be pathogenic or likely
             pathogenic, which may also be classified as "significant" or "likely significant"
             (patients with variants of "uncertain significance " are excluded)

        or

        -Patients with Catenin Alpha 1 (CTNNA1) and partner and localizer of breast cancer 2
        (BRCA2) (PALB2) germline mutations suspected to be, or reported to be, associated with
        hereditary diffuse gastric cancer (HDGC) syndrome.

        or

          -  In the absence of a germline CDH1 mutation, patients must meet clinical criteria for
             genetic testing due to a history suggestive of Hereditary Diffuse Gastric Cancer
             (HDGC) syndrome

          -  Age greater than or equal to 18 years.

          -  Physiologically able to undergo upper endoscopy.

          -  Ability to understand and the willingness to sign a written informed consent document.

          -  Pregnant women are eligible during second trimester of pregnancy if clinically
             indicated for evaluation of cancer.

        EXCLUSION CRITERIA:

          -  Current use of therapeutic anticoagulation medication

          -  Known bleeding disorder or thrombocytopenia.

          -  Unstable angina or recent (within 3 months) myocardial infarction

          -  Any clinical contraindication to general anesthesia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: The Role of Cyclooxygenase Activity in the Endothelial Function of Hypertensive and Hypercholesterolemic Patients (NCT00001742)

Eligibility criteria:
Patients (men and nonpregnant women) with systemic hypertension and patients with
        hypercholesterolema will be included for this study.

        Patient with aspirin allergies and those with a platelet count less than 50,000 will be
        excluded.

        Volunteers cannot be in any kind of medication while participating in this study.

        No history of diabetes, peripheral vascular disease, coagulopathy, or vasculitis.

        Must be capable of rendering informed consent for all procedures.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Histopathological Diagnosis of Adenomyosis (NCT02340533)

Eligibility criteria:
Inclusion Criteria:

          -  females complaining of pelvic congestion: dysmenorrhea, dyspareunia, chronic pelvic
             pain, menorrhagia, metrorrhagia

        Exclusion Criteria:

          -  refusal of the patient to get enrolled in the study
Female
Accepts Healthy Volunteers
Subject must be at least 38 Years old.
Subject must be at most 52 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Study on Von Willebrand Disease and Hemophilia in Cuenca, Ecuador (NCT01589848)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects living at urban and rural parishes from Cuenca district.

          -  Subjects referred from professionals of public and private health services, who have
             filled the initial hemorrhage survey.

          -  Must be referred women who sign the informed consent form.

          -  Patients who answer the standardized bleeding score questionnaire (BS).

          -  Patients who answer the quality of life questionnaire (SF-12).

          -  Patients who answer the socio-economic survey.

          -  Patients who accept to provide a venous blood sample for the initial laboratory tests.

        Exclusion Criteria:

          -  Women with organic or hormonal bleeding etiologies.

          -  Patients taking medicines which may affect the coagulation cascade or the number or
             function of platelets.

          -  Those women who otherwise do not comply with the inclusion criteria.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Safety and Efficacy of BGS649 in Obese, Hypogonadotropic Hypogonadal Men (NCT01200862)

Eligibility criteria:
Inclusion Criteria:

          -  Males who meet the criteria of obese, hypogonadotropic hypogonadism defined as:

               -  Patients with a Body Mass Index (BMI) ≥ 30 kg/m2

               -  Patients with a morning serum total testosterone level < 300 ng/dL on at least
                  two separate occasions during the Screening and/or Baseline periods.

               -  Patients with inappropriately low gonadotropins at screening given the low
                  testosterone:

          -  Luteinizing hormone (LH) ≤ ULN

          -  Follicle stimulating hormone (FSH) ≤ ULN

          -  Estradiol within or above the normal range (defined as ≥ LLN of the approved assay)

               -  Normal hypothalamic/pituitary function, including:

          -  Prolactin: within the normal range

          -  Thyroid stimulating hormone (TSH): within the normal range

          -  Ferritin: within the normal range

          -  Patients agree to use a barrier method of contraception (e.g., condom), for the
             duration of the study and for at least 3 months following their Study Completion visit
             to prevent BGS649 exposure to their partners.

        Exclusion Criteria:

          -  Patients with hypogonadism, not related to obesity or as a result of other underlying
             issues

          -  Patients with significant major organ class illness (e.g. kidney or liver disease).

          -  Other protocol-defined inclusion/exclusion criteria may apply
Male
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Safety and Efficacy of Carbohydrate Drink Ingested Two Hours Before Upper Endoscopy Under General Anaesthesia (NCT01471600)

Eligibility criteria:
Inclusion Criteria:

          -  age >= 18 yrs

          -  undergoing upper endoscopy procedure under general anesthesia without emergency

          -  informed written consent

        Exclusion Criteria:

          -  emergency

          -  might impair gastrointestinal motility (intestinal obstruction, stenosis)

          -  diseases of the central and peripheral nervous system or neuromuscular diseases

          -  drug-induced gastric emptying disorders

          -  pregnancy

          -  ionic disorders (hyponatremia<125mmol/l ; hypokalemia<3,5mmol/l

          -  hemodynamic disorders (systolic arterial pressure <100mmHg)

          -  unstable diabetes (glycemia>2,5g/l) ± insulin- dependent diabetes ± diabetic
             gastroparesis

          -  the potential for difficult airway management

          -  understanding of the information

          -  patient with bad prognosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Ventilatory Muscle Training by Breath-Stacking in Healthy Youngsters (NCT03258944)

Eligibility criteria:
Inclusion Criteria:

          -  No signs and symptoms of pulmonary diseases, normal ventilatory muscle strength and
             agreement to participate and sign the informed consent form.

        Exclusion Criteria:

          -  Presenting neuromuscular diseases, claustrophobia, ruptured eardrum, history of
             spontaneous pneumothorax and playing wind instruments or being a singer. Sample loss
             will be considered as non-attendance at all training sessions.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 24 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Narcolepsy - New Potential Treatment (NCT02077036)

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent

          -  Diagnosed with narcolepsy (diagnose code G47.4)

          -  16 - 60 years of age

          -  MSLT has shown hypersomnia (sleeping latency < 8 min) & 1 episode REM

          -  HLA-type associated with increased occurrence of narcolepsy

        Exclusion Criteria:

          -  Reduced cognitive function

          -  Other relevant organ disease (that could affect the study results or put the patient
             at risk)

          -  Ongoing bacterial infection in the nose

          -  Comorbidity that can increase the risk of bleeding

          -  Has received treatment with an implantable stimulator or other implantable product in
             the head and / or in the neck

          -  Known pronounced septal deviation

          -  Known allergy to polyvinylchloride or medicinal liquid paraffin

          -  Women not using adequate contraceptives

          -  Participated in a clinical investigational drug trial within the previous 30 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy and Safety Study of Ingavirin® 90 mg Once Daily to Treat Influenza and Other Acute Viral Infections in Adults (NCT03154515)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with clinically diagnosed influenza, body temperature ≥ 38 ºС or other acute
             respiratory viral infection, body temperature ≥ 37 ºС, with no less than 2 symptoms of
             catarrhal and intoxication each:

               -  Intoxication symptoms: Dizziness, headache, chills, fever, sweating, fatigue,
                  myalgia, pain while moving eyes, flushing, pale skin, sleep disturbances,
                  decreased appetite, nausea, vomiting, epistaxis, cyanosis, meningeal signs.

               -  Catarrhal symptoms: Sore throat, rhinorrhea and nasal congestion, difficulty
                  swallowing, hoarseness, stridor, wheezing, rattling dry and wet cough,
                  expectoration.

          -  Laboratory confirmation of viral origin of the disease

          -  Uncomplicated influenza and other acute respiratory viral infections

          -  Interval between onset of symptoms and enrollment to the study not more than 48 hours

          -  Have read, understood and signed an informed consent form

        Exclusion Criteria:

          -  Complicated course of influenza and other acute respiratory viral infections
             (secondary bacterial infection)

          -  Pregnancy and Breastfeeding

          -  Severe decompensated or unstable medical or psychiatric conditions (any diseases or
             conditions that threaten the life of the patient or worsen the patient's prognosis)

          -  Cancer, HIV infection, tuberculosis, including those in history

          -  History of alcohol and drug abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment