araag2/NLI4PR huggingface dataset:
Clinical trial: Evaluation of a Simple Pharmacokinetic Tool (myPKFiT™) to Guide Personalized Factor VIII Dosing in Patients With Hemophilia (NCT02750085)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of Hemophilia A;

          -  Severe disease (FVIII <2%);

          -  Receiving ADVATE for prevention of bleeding (prophylaxis) or receiving ADVATE on
             demand and a candidate for prophylaxis;

          -  Body weight ≤120 kg; and ≥12kg;

        Exclusion Criteria:

          -  FVIII inhibitor positive (level of ≥0.6 Bethesda Units [BU] per mL using the Nijmegen
             modification of the Bethesda assay). Inhibitor status to be documented as negative
             prior to study enrollment according to the two most recent, consecutive inhibitor
             assays on record. If patients have < 50 exposure days, an assay will be completed
             centrally within a reasonable timeframe (approximately 8 weeks suggested) to make sure
             that they are negative.

          -  Body weight >120 kg or <12kg;

          -  Human immunodeficiency virus (HIV) positivity with cluster of differentiation 4 (CD4)
             count < 200 / microliter;

          -  Significant hepatic dysfunction, alanine aminotransferase (ALT) or aspartate
             aminotransferase (AST) >5 times upper limit of normal

          -  History of recent events that might affect FVIII half-life (e.g., infection, surgery
             or an invasive procedure) within 2 weeks of blood sampling.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Vital Sign Comparison Between Lifelight and Standard of Care - Development (NCT04003662)

Eligibility criteria:
Inclusion Criteria:

          -  I1. Sufficiently conversant in the English language to satisfy I3.

          -  I2. Able and willing to comply with all study requirements.

          -  I3. Able and willing to provide written informed consent to participate (including by
             parent or legal guardian if under 16 years old).

        Exclusion Criteria:

          -  There are no exclusion criteria.
No condition on gender to be admitted to the trial.

Subject must be at least 3 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Social Cognition and Turner Syndrome (NCT01687842)

Eligibility criteria:
Inclusion criteria:

          -  Turner syndrome with homogeneous 45,X karyotype.

          -  Age between 8 and 18 years.

          -  Somatic state compatible with the evaluation.

          -  Functional language and IQ ≥ 80 for the transfer tests

          -  Informed consent signed by the holders of parental authority, the patient and the
             mother for her own participation (DNA collection).

          -  Affiliation to Social Security (beneficiary or assignee).

        Exclusion Criteria:

          -  Additional condition associated with an autism spectrum disorder

          -  Turner syndrome not related to an homogeneous 45,X karyotype
Female
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Circulating Transforming Growth Factor Beta (TGF-β) in Individuals With Marfan Syndrome (NCT01361087)

Eligibility criteria:
Inclusion Criteria:

          -  Individual with Marfan syndrome consented in to the Main Atenolol Vs. Losartan NIH
             study.

        Exclusion Criteria:

          -  Subjects in the main PHN Marfan trial who have not achieved the maintenance drug
             dosing or who have stopped taking study drug.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 24 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of Auricle Position on Tympanic Thermometry (NCT04463537)

Eligibility criteria:
Inclusion Criteria:

        The patients who were 18 years old or older, conscious, without communication issues,
        volunteers, not diagnosed with otitis media, who did not have a fever.

        Exclusion Criteria:

        havin fever, Being under the age of 18, not volunteers.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Dating Violence and HIV Prevention in Girls: Adapting Mental Health Interventions (NCT01326195)

Eligibility criteria:
Inclusion Criteria:

          -  Adolescent must be English-speaking

          -  Adolescent must have a lifetime history of physical dating violence perpetration or
             victimization

        Exclusion Criteria:

          -  Current enrollment in an intervention for dating violence or HIV prevention
Female
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Epigenetic Tools as Prognostic Predictors in Covid19 (NCT04411563)

Eligibility criteria:
Inclusion Criteria:

          -  All patients between the ages of 18 and 65 included will suffer from COVID 19, and
             specific treatment should not yet be initiated.

          -  COVID 19 diagnosis of patients will be based on full medical history, thorough
             clinical examination, radiological imaging, laboratory assessment, and SARS-CoV-2
             analysis by RT-PCR.

        Exclusion Criteria:

          -  People with chronic lung disease or previous AC surgery

          -  People with immune deficiency or cancer patients

          -  Patients receiving immunosuppressive therapy for autoimmune disease

          -  People with neurological diseases affecting the respiratory muscles, such as
             hypotonia.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Management of Acute Ankle Sprain With Sodium Hyaluronate (NCT02091674)

Eligibility criteria:
Inclusion Criteria:

          -  • 18 years and older

               -  first or second degree lateral ankle sprain within 48 h of administration of
                  study drug

               -  reported moderate (45 - 60 mm) to severe (>60 mm) ankle pain on full weight
                  bearing on the Patient's Assessment of Ankle Pain using a 100 mm VAS

               -  available for the duration of the study (90 days)

        Exclusion Criteria:

          -  • Bilateral ankle sprain

               -  Ipsilateral knee injury

               -  Third-degree sprain

               -  Previous ankle sprain within 6 months

               -  Patients who had recently used anti-inflammatory medications, muscle relaxants
                  psychotropic medications that could confound the results

               -  Patients with a history of severe GI, renal, or hepatic disease

               -  Patients with rheumatic diseases

               -  History of drug or alcohol abuse

               -  Pregnant or lactating, or a woman of childbearing potential not willing to use an
                  acceptable method of contraception during the study

               -  Having received investigational product within 30 days of the Day 1 visit
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction
Clinical trial: Levonorgestrel-releasing Intrauterine System Versus a Low-dose Combined Oral Contraceptive for Management of Adenomyosis Uteri (NCT03037944)

Eligibility criteria:
Inclusion Criteria:

          -  Women patient aged 30-45 years

          -  Diagnosed adenomyosis by transvaginal ultrasound or MRI or 3D ultrasound

          -  Patient complains of heavy menstrual bleeding or dysmenorrhea or both

          -  Living in a nearby area to make follow-up reasonably possible

          -  Planning for birth spacing for at least 2 years.

        Exclusion Criteria:

          -  Pregnancy or seeking fertility

          -  Severe underlying comorbidities (hepatic, oncological)

          -  Pelvic inflammatory disease

          -  Other cervical or uterine pathologies

          -  Deep venous thromboembolism

          -  Hormonal therapy contraindications

          -  Endometriosis or fibroid
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Intravenous Laser Irradiation Effect on Treatment Resistant Thin Endometrium (NCT03081130)

Eligibility criteria:
Inclusion Criteria:

          -  We will recruit 30 poor ovarian responders and thin endometrium patients

        Exclusion Criteria:

          -  women with underlying medical diseases, such as diabetes or hypertension
Female
Accepts Healthy Volunteers

Subject must be at most 45 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: MR Guided tDCS in Alzheimer's Disease (NCT03325205)

Eligibility criteria:
Inclusion Criteria:

          -  Alzheimer's Disease, mild and moderate stage

        Exclusion Criteria:

          -  Other neurological diseases or injuries

          -  Stroke

          -  Cancer

          -  Psychiatric disorders (moderate/ severe depression, psychosis)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment