araag2/NLI4PR huggingface dataset:
Clinical trial: Study Investigating a PEGylated Recombinant Factor VIII (BAX 855) for Hemophilia A (PROLONG-ATE Study) (NCT01736475)

Eligibility criteria:
Main Inclusion Criteria:

          -  Participant and/or legal representative has/have voluntarily provided signed informed
             consent

          -  Participant is 12 to 65 years old at the time of screening

          -  Participant is male with severe hemophilia A (Factor VIII (FVIII) clotting activity <
             1%) as confirmed by central laboratory at screening after the appropriate washout
             period or a documented FVIII clotting activity <1%

          -  Participant has been previously treated with plasma-derived FVIII concentrates or
             recombinant FVIII for ≥150 documented exposure days (EDs)

          -  Participant is currently receiving prophylaxis or on-demand therapy with FVIII

          -  Participant is willing and able to comply with the requirements of the protocol

        Main Exclusion Criteria:

          -  Participant has detectable FVIII inhibitory antibodies (≥ 0.6 Bethesda Units (BU)
             using the Nijmegen modification of the Bethesda assay) as confirmed by central
             laboratory at screening

          -  Participant has history of FVIII inhibitory antibodies (≥ 0.4 BU using the Nijmegen
             modification of the Bethesda assay or ≥ 0.6 BU using the Bethesda assay) at any time
             prior to screening

          -  Participant has been diagnosed with an inherited or acquired hemostatic defect other
             than hemophilia A (eg, qualitative platelet defect or von Willebrand's disease).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Transcriptomic Profile of Endometrium in Different Histological Dating of Hormone Replacement Cycle (NCT03222882)

Eligibility criteria:
Inclusion Criteria:

          -  The inclusion criteria for RIF group were: unexplained repeated implantation failure
             (RIF) is defined as the absence of a gestational sac on ultrasound at 5 or more weeks
             after embryo transfer (ET) after 3 embryo transfers with high quality embryos or after
             the transfer of ≥10 embryos in multiple transfers.

        The inclusion criteria for control group were: (1) age <35 years; (2) unregular menstrual
        cycles of >37 days; (3) baseline follicle- stimulating hormone (FSH) < 9.0 IU/L; (4)
        endometrial thickness ≥7.0 mm on the day of hCG administration.

        Exclusion Criteria:

          -  The exclusion criteria were: (1) uterine abnormalities (double uterus, bicornuate
             uterus, unicornuate uterus); (2) intrauterine adhesions（moderate - severe）,
             endometriosis, adenomyosis, untreated hydrosalpinx, uterine fibroids (submucosal
             fibroids, nonmucosal fibroids >4.0 cm and/or endometrial pressure) (3) history of
             adverse pregnancy (including spontaneous abortion, stillbirth, and fetal
             malformation).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Survey on Patient Satisfaction Rate for Mirena Use in Heavy Menstrual Bleeding (NCT00874653)

Eligibility criteria:
Inclusion Criteria:

          -  Women diagnosed with Idiopathic Menorrhagia and Mirena inserted for a period no longer
             than three months according to the assessment of the investigator and according to the
             international and national guidelines. These women should also accept to be on
             contraception during the time period that they have Mirena in situ

          -  Body Mass Index = 18-30

        Exclusion Criteria:

          -  One or more of the following disorders: Current or recurrent pelvic inflammatory
             disease; infection of the lower genital tract; postpartum endometritis; septic
             abortion during the past three months; cervicitis; cervical dysplasia; uterine or
             cervical malignancy; undiagnosed abnormal uterine bleeding; congenital or acquired
             abnormality of the uterus including fibroids if they distort the uterine cavity;
             conditions associated with increased susceptibility to infections; acute liver disease
             or liver tumor; known hypersensitivity to any of the constituents of the product

          -  Nulliparity

          -  Consumption of Iron, Antiprostaglandins, hormonal drugs and any medication that could
             effect bleeding should be stopped at least 3 months before the first visit and should
             not be used during the course of the study.

          -  History of diabetes mellitus, cardiovascular disease and thyroid abnormalities

          -  Anticoagulation therapy

          -  Cancer history including breast cancer
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 49 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Fetal Fibronectin as a Predictor of Successful Induction of Mid-trimester Abortion (NCT02694198)

Eligibility criteria:
Inclusion Criteria:

          -  Singleton pregnancy.

          -  14-24 weeks gestation..

          -  Missed miscarriage

        Exclusion Criteria:

          -  History of pulmonary, hepatic, renal, or cardiovascular diseases.

          -  History of previous cesarean section and other uterine surgeries as hysterotomy and
             myomectomy.

          -  Inevitable abortion.

          -  Placenta covering internal os.

          -  History of any cervical surgery as cervical amputation, cauterization or dilatation.

          -  Premature rupture of membranes.

          -  Any vaginal bleeding.

          -  Contraindications for misoprostol as hypersensitivity to misoprostol, chronic adrenal
             insufficiency and inherited porphyrias.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study to Analyze Symptoms Prevalent in Early PD (Dysphonia, Tremor) (NCT04288804)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Parkinson's Disease (PD)

          -  Healthy

        Exclusion Criteria:

          -  Subject does not have clinical diagnosis of PD, however, has another neurological
             disorder/disease that manifests with symptoms of tremor or dysphonia

          -  Subject diagnosed with PD does not have dysphonia and tremor
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Contradiction
Clinical trial: Development of a Specific Measure for Assessing Adherence in Adult Patients With Hemophilia. (NCT02197611)

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with hemophilia A or B.

          -  Patients over 18 years of age.

        Exclusion Criteria:

          -  Patients with neurological or cognitive impairments that hinder oral and written
             comprehension.

          -  Patients who have not signed the informed consent document
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of the Effects of Muscular Activity on Iron Metabolism (NCT00378469)

Eligibility criteria:
Inclusion Criteria:

          -  Male individuals aged between 18 and 40 years old

          -  Body mass index (BMI) between 18 and 25

          -  Normal at clinical examination

          -  Normal biological variables

          -  Written informed consent

        Exclusion Criteria:

          -  Mutation C282Y of the HFE gene

          -  Iron metabolism abnormality

          -  Inflammatory syndrome

          -  Chronic pathology or ongoing treatment

          -  Tobacco smoking, alcohol consuming more than 30g/day

          -  History of transfusion or blood-giving within 3 months

          -  Positive serology for hepatitis B virus (HBV), hepatitis C virus (HCV) or HIV.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: ACTIONS - Aortic Counterpulsation to Improve Outcomes in Noncardiac Surgery (NCT01253356)

Eligibility criteria:
Inclusion Criteria:

          -  Patients > 18 years with planned elective major abdominal, noncardiac thoracic, head
             and neck, vascular, or orthopedic surgery and guideline-treated iscehmic heart disease
             with left ventricular dysfunction (systolic ejection fraction < or = 30%)

        Exclusion Criteria:

          -  Unstable coronary syndromes Decompensated or NYHA Class IV heart failure Hemodynamic
             instability Cardiac biomarker instability Need for surgical procedure interfering with
             placement of IABP Cardiogenic shock Septic shock Contraindication to IABP use Clinical
             need for IABP ASA score > or = 5 Pregnancy Inability to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Anastrozole Administration in Elderly Hypogonadal Men (NCT00136695)

Eligibility criteria:
Inclusion Criteria:

          -  Men ages 60 and older

          -  Serum testosterone between 150-300 ng/dL

          -  Symptoms suggestive of androgen deficiency
Male
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Natural Cycle/Progesterone Fortified Protocol for Endometrial Preparation for Frozen/Thawed Embryo Transfer (NCT02749344)

Eligibility criteria:
Inclusion Criteria:

          1. Women younger than 39 at the time of cryopreservation

          2. Regular menstrual cycles of at least 26 days and at most 32 days.

          3. Women with no more than 3 failed prior embryo transfers

          4. Patients with embryos cryopreserved 48 hours after ovum pick up

        Exclusion Criteria:

          1. Women with known uterine malformations or significant myomas

          2. Women with elevated Progesterone of at least 1.5 ng/mL for the duration of more than
             72 hours before embryo transfer can be performed

          3. Women suspected of having endometrial pathology based on previous treatment cycles
             i.e. "thin endometrium", polyps, adhesions

          4. Women whose embryos did not survive the thawing process, i.e. no embryos available for
             transfer after thawing

          5. Women without follicular development
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction