araag2/NLI4PR huggingface dataset:
Clinical trial: The Effect of N-Acetylcystein on Quality of Life and Air Trapping During Rest and After Exercise (NCT00476736)

Eligibility criteria:
Inclusion Criteria:

          -  30 Moderate COPD (GOLD classification) , AGE 45-70, both sexes.

          -  Treated with inhaled steroids and long acting beta agonists.

        Exclusion Criteria:

          -  Active ischemic heart disease, heart failure, orthopedic problems that preclude
             ergometric bicycle activity.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Testicular Injection of Autologous Stem Cells for Treatment of Patients With Azoospermia (NCT02041910)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with non-obstructive Azoospermia

          -  Patients between 25 - 60 years old.

        Exclusion Criteria:

          -  Patients with obstructive Azoospermia

          -  Men with previous surgery in testis

          -  Men with infectious genital diseases and anatomical abnormalities of the genital tract

          -  Those with major medical problems such as malignancy, hepatitis, etc.

          -  Chromosomal aberration (e.g. Y microdeleion, trisomy….)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Hemophilia Inhibitor Eradication Trial (NCT04303572)

Eligibility criteria:
Inclusion Criteria:

          1. Male adults or children > 4 months of age.

          2. Severe hemophilia A (FVIII < 0.01 U/ml).

          3. Current or past high-responding inhibitor, anti-FVIII >= 5.0 B.U., ITI-refractory or
             ITI-naive.

        Exclusion Criteria:

          1. Acquired hemophilia or any bleeding disorder other than hemophilia A.

          2. Current use of Emicizumab, or if used, > 8 weeks since last treatment.

          3. Use of an experimental drug(s).

          4. Surgery anticipated in the next 48 weeks.

          5. Life expectancy less than 5 years.

          6. Patient/parent/caretaker unable or unwilling to keep a personal diary of bleeding
             frequency and study drug treatment, make monthly visits and blood draws at weeks 4, 8,
             12, 24, 36, and 48.

          7. Other illness, condition, or reason in the opinion of the investigator that would make
             the patient unsuitable for the trial.
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Duration of Antibiotic Treatment of Erythema Migrans (NCT00910715)

Eligibility criteria:
Inclusion Criteria:

          -  solitary erythema migrans in patients > 15 years

        Exclusion Criteria:

          -  a history of Lyme borreliosis in the past

          -  pregnancy or lactation

          -  immunocompromised status

          -  serious adverse event to doxycycline

          -  taking antibiotic with antiborrelial activity within 10 days

          -  multiple erythema migrans or extracutaneous manifestations of Lyme borreliosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.


Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee (NCT01444365)

Eligibility criteria:
Inclusion Criteria:

          -  History of osteoarthritis (OA) of the knee joint and meeting American College of
             Rheumatology (ACR) Clinical and Radiographic criteria,

          -  Currently taking nonsteroidal anti-inflammatory drugs (NSAIDs) and still experiencing
             pain as per the protocol requirements.

          -  Willing to washout of analgesics and to follow treatment plan, visit schedules and
             study procedures.

        Exclusion Criteria:

          -  Diagnosis of rheumatoid arthritis, autoimmune disorder, arthritis other than
             osteoarthritis involving the study joint, or other painful syndrome that could
             interfere with the assessment of pain at the study joint

          -  Any cardiac, respiratory, neurological, psychiatric disorder or any other medical
             condition or illness that is not well controlled with treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Amlodipine Prevents Morning Blood Pressure Surge Study (NCT01030081)

Eligibility criteria:
Inclusion Criteria:

          -  Age: 40 to 70 years old.

          -  Untreated patients or those on monotherapy of antihypertensive drugs but with
             uncontrolled blood pressure in the ranges of 140-160/90-100 mmHg.

          -  Patients on antihypertensive medication should discontinue their antihypertensive
             treatment for at least 4 weeks. During the 4 weeks run-in period, all patients should
             have 2 clinic visits. At each visit, blood pressure will be measured 3 times
             consecutively. The average of these 6 readings from 2 clinic visits should be in the
             range of 140-180 systolic or 90-110 diastolic mm Hg. 24-h mean blood pressure should
             be equal to or higher than 130 mm Hg systolic and 80 mm Hg diastolic.

          -  The patients should sign the consent form prior to the participation in the trial,
             adhere to the study design, and can visit the outpatient clinic on his/her own.

        Exclusion Criteria:

          -  With life-threatening disease.

          -  With myocardial infarction or stroke in the last 2 years.

          -  With contraindications to a dihydropyridine calcium channel blocker.

          -  Current participation in another trial or trials.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study About Patients Using Copper Intrauterine Device (NCT01541241)

Eligibility criteria:
Inclusion Criteria:

          1. Regularly menstruating women before CIUD insertion.

          2. Age between 18 and 35 years.

          3. Hormonal treatment has not been taken at least two months before the study.

          4. Non steroidal anti-inflammatory drugs has not been taken 24 hours before the
             examination.

        Exclusion Criteria:

          1. Pregnancy.

          2. The presence of pelvic pathology as ovarian cysts, pelvic endometriosis, endometrial
             polyps or fibrosis.

          3. Present or past history of pelvic inflammatory disease.

          4. Patients on hormonal treatment in the last two months before the study.

          5. Patients on non steroidal anti-inflammatory drugs last 24 hours before the
             examination.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of Intramuscular and Intravenous ACTH Stimulation Test in Normal Volunteers (NCT03752190)

Eligibility criteria:
Inclusion Criteria:

        - Healthy volunteers

        Exclusion Criteria:

        - Know history of pituitary or adrenal disease. Current or recent use of glucocorticoids,
        and use of oral estrogen, pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application (NCT03998098)

Eligibility criteria:
Inclusion Criteria:

          1. Subject is informed and has been given ample time and opportunity to think about
             his/her participation and has given his/her written informed consent

          2. Subject is ≥18 years of age

          3. Subject's health status: individual is considered to be healthy (hypertension and
             hypotension is permissible. Other stable diseases at the time of testing are also
             permissible)

          4. Subject is capable of undergoing controlled hypoxaemia to the levels called for the in
             the protocol with minimal medical risk (unless only participating in the blood
             pressure study).

        Exclusion Criteria:

          1. Subject cannot expose their face fully for a reading to be taken

          2. Subject is unable to give informed consent

          3. Subject is outside of the specified age range

          4. Subject has already taken part in the study (all 4 sub studies)

          5. Subject with significant irregular heart rhythm or any disease that might affect the
             results of the study

          6. Subject is not capable of undergoing controlled hypoxia and would be placed at undue
             medical risk if this occurred

          7. Subject has any contraindications identified that would deem them unsuitable to take
             part
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: A Clinical Double Blind, Randomized Study of the Efficacy of Hyperuricemia Treatment With Anserine Product. (NCT00208000)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female patients, age between 18 to 60 years

          -  With the data of serum uric acid level more than 8.0 mg/dl within 2 weeks before the
             initiation of study

          -  Signed informed consent obtained prior to inclusion into the study

        Exclusion Criteria:

          -  Pregnant women.

          -  Acute onset of gouty arthritis or renal stone

          -  Significant liver or renal dysfunction, hematological disease, oncological disease, or
             other life threatens disorders.

          -  Condition that need the management of diuretics or analgesics agent

          -  Have been administrated by anti-hyperuricemia agent or healthy food with in 4 weeks
             before the initiation of study.

          -  The serum uric acid level could be decrease to lower than 8 mg/dl by diet control.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction