araag2/NLI4PR huggingface dataset:
Clinical trial: A Study With RO4917523 in Patients With Fragile X Syndrome (NCT01015430)

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients, 18 to 50 years of age

          -  Fragile X Syndrome

          -  IQ less than 75

          -  Reliable caregiver

        Exclusion Criteria:

          -  Current psychosis or presumption of psychosis

          -  History of suicidal behavior or considered a high suicidal risk

          -  Severe self-injurious behavior

          -  Any unstable medical condition other than Fragile X Syndrome (e.g. hypertension,
             diabetes)

          -  Current seizure disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Influence of Antiphospholipid Antibodies on the Relationship Between Hyperurecemia, Gout and Metabolic Syndrome (NCT01818505)

Eligibility criteria:
Inclusion Criteria:

          1. Patient with gouty arthritis

          2. Patient with asymptomatic hyperurecemia

          3. Patient of osteoarthritis but without hyperuricemia and gout

        Exclusion Criteria:

        1.Patient younger than 20 y/o.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pityriasis Lichenoides Chronica, Role of Streptococcal Infection and Azithromycin (NCT03831269)

Eligibility criteria:
Inclusion Criteria:

          1. Patients with classic papular eruption of PLC (scaly erythematous papules with
             mica-like scales) with diagnosis documented histopathologically with or without
             associated hypopigmented lesions

          2. Age: > 6 years

          3. Both sexes.

        Exclusion Criteria:

          1. Patients presenting with only hypopigmented macules whom their skin biopsy revealed
             PLC.

          2. Patients with hypopigmented lesions that reveal mycosis fungoides pathologically.

          3. Patients with PLC associated with classic MF.

          4. Patients with known absolute contraindications to NB-UVB.

          5. Patients with impaired liver and/or kidney functions.

          6. Patients with history of any heart disease.

          7. Patients with known hypersensitivity to Azithromycin

             -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Comparative Effectiveness Dementia & Alzheimer's Registry (NCT03687710)

Eligibility criteria:
Inclusion Criteria:

          -  18 years of age or older

          -  family history of Alzheimer's disease and no cognitive complaints OR subjective
             cognitive decline OR preclinical AD OR mild cognitive impairment due to AD or other
             conditions

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Conventional Versus Ultrasound-guided Transbronchial Needle Aspiration for the Diagnosis of Hilar/Mediastinal Lymphadenopathies (NCT01658280)

Eligibility criteria:
Inclusion Criteria:

          -  age ≥ 18years;

          -  presence of at least one hilar/mediastinal adenopathy >1 cm on short axis assessed by
             contrast-enhanced CT scan in at least one approachable stations other than 2R and 2L;

          -  ability to give an informed consent.

        Exclusion Criteria:

          -  presence of mediastinal adenopathy in stations 2R and 2L;

          -  coagulopathy or bleeding diathesis that cannot be corrected;

          -  severe refractory hypoxemia;

          -  unstable hemodynamic status;

          -  inability to give an informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? Entailment
Clinical trial: Flemish Inguinal and Femoral Hernia Prospective Registry (NCT04623580)

Eligibility criteria:
Inclusion criteria

          -  Consecutively all patients with a groin hernia (inguinal and/or femoral hernia)
             operated starting 01.01.2018.

          -  Male and female

          -  18 years or older

          -  Operated of supervised by a participating surgeon (participating in this study is not
             necessarily by a whole surgical department of a hospital, but by specific surgeons)

          -  Elective and emergency surgery

          -  Primary and recurrent hernia

          -  Metachronous and synchronous hernia

          -  Signed informed consent form

        Exclusion criteria

          -  Younger than 18 years

          -  Not operated or supervised by participating surgeon

          -  Pregnant at inclusion in the registry

          -  No signed informed consent form
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Pleurectomy/Decortication Followed by Intrathoracic/Intraperitoneal Heated Cisplatin for Malignant Pleural Mesothelioma (NCT00165555)

Eligibility criteria:
Inclusion Criteria:

          -  Histopathologic confirmation of malignant pleural mesothelioma

          -  Patients who are able to tolerate surgical cytoreduction but unable to undergo
             extrapleural pneumonectomy due to poor cardiopulmonary reserve or tumor invasion

          -  18 years of age or older

          -  Malignancy is confined to the affected hemithorax.

          -  Grossly normal cardiac function with an EKG showing no cardiomyopathy or acute changes

          -  Evidence of adequate renal and hepatic function

          -  Karnofsky performance status of 70% or greater

        Exclusion Criteria:

          -  Extended disease outside the ipsilateral hemithorax as determined radiologically and
             intraoperatively

          -  Distant metastases

          -  Non-malignant systemic disease

          -  Active concomitant malignancy

          -  Psychiatric or addictive disorders which would preclude obtaining informed consent

          -  Prior treatment within the last 2 months, other than surgical resection for their
             current malignancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Adenomyosis: Genomic Mechanisms and Biological Response (NCT03428854)

Eligibility criteria:
Inclusion Criteria:

          -  Abnormal bleeding in the presence of Adenomyosis as demonstrated by MRI

        Exclusion Criteria:

          -  Other causes of abnormal bleeding such as fibroids, endometrial polyps, malignancy

          -  Presence of endometriosis
Female

Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study Assessing the Effects of Chemotherapy in Advanced Esophagogastric Adenocarcinoma (NCT02177552)

Eligibility criteria:
Key Inclusion Criteria:

          -  Patients with histologically verified, unresectable or metastatic, HER2-negative,
             adenocarcinoma of the esophagus or stomach

          -  Men or women less than 80 years of age

          -  Performance status 0 or 1

          -  Life expectancy >12 weeks

          -  Adequate organ-function

          -  Written informed consent

        Key Exclusion Criteria:

          -  Prior chemotherapy for adenocarcinoma of the esophagus or stomach if the
             chemotherapy-free interval is less than 6 months

          -  Progression on first-line chemotherapy for unresectable or metastatic adenocarcinoma
             of the esophagus or stomach

          -  Chemotherapy with epirubicin, oxaliplatin, carboplatin, cisplatin or docetaxel less
             than 6 months before study entry

          -  Prior cumulative dose of >300 mg/m2 of epirubicin

          -  Grade ≥ 2 side-effects from previous chemotherapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 79 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment