araag2/NLI4PR huggingface dataset:
Clinical trial: A Primary Care Behavioral Approach for Addressing Childhood Overweight (NCT00284557)

Eligibility criteria:
Inclusion criteria included that the child must be:

          1. Obese (BMI ≥ 95th percentile for age and gender) or at-risk for obesity (85th ≥ BMI >
             95th percentile for age and gender);

          2. African-American by parent report;

          3. 7-11 years of age;

          4. Without any medical or psychological condition that would make weight loss or physical
             activity dangerous, or psychological disorders that would make adoption of health
             behaviors difficult;

          5. Without any complications of obesity that indicate prompt referral to a pediatric
             obesity treatment center for more aggressive weight loss therapy;

          6. Together with the parent/caregiver indicate that they are ready to make changes in
             their eating and physical activity behaviors;

          7. Have a parent/caregiver willing to participate.

        Exclusion Criteria:

        As noted above, to participate in this study the child must not have a medical or
        psychological condition that would make weight loss or physical activity dangerous,
        psychological disorders that would make adoption of health behaviors difficult, or
        complications of obesity that necessitate prompt referral to a pediatric obesity treatment
        center for more aggressive weight loss therapy. Examples of medical or psychological
        conditions that would render the child ineligible for this study include uncontrolled or
        poorly-controlled asthma or hypertension, bulimia, mental retardation or severe learning
        disability, as well as pseudotumor cerebri, sleep apnea, obesity hypoventilation syndrome,
        and slipped capital femoral epiphysis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 11 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Acute Effects of Intravenous Iron on Oxidative Stress and Endothelial Dysfunction in Non-dialysis CKD (NCT03388385)

Eligibility criteria:
Inclusion Criteria:

          -  Chronic kidney disease stages G3-G5 (defined according to KDIGO criteria);

          -  Anemia (defined according to KDIGO criteria) and iron deficiency defined as serum
             ferritin < 100 ng/mL and/or TSAT < 20% (KDIGO).

        Exclusion Criteria:

          -  contraindications of intravenous iron therapy: iron allergy, active infection,
             hemochromatosis, iron overload (serum ferritin > 500 ng/mL and/or transferrin
             saturation > 50%);

          -  treatment with iron and erythropoiesis-stimulating agents (at the time of recruitment
             and 6 months previously);

          -  active smoker status;

          -  antioxidant food supplements treatment in the last 3 months;

          -  clinically manifest bleeding;

          -  another cause of anemia (hemoglobinopathies, vitamin B12 and/or folic acid deficiency
             suggested by the megaloblastic peripheral blood smears's appearance, multiple myeloma
             and other paraproteinemias);

          -  severe anemia (Hb < 7 g/dl);

          -  baseline FMD < 7% (the existence of atherosclerosis which limits arterial reactivity);

          -  cancer (currently or in the past 6 months);

          -  hepatopathies (increased serum transaminases ≥ 3 x normal value) or hepatic impairment
             ≥ grade Child B;

          -  autoimmune disorders or significant inflammation (as defined by C-reactive protein > 5
             mg/L);

          -  pregnancy or lactation;

          -  participation in other clinical trials over the upast 3 months;

          -  patient unwillingness.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of Menses in Congenital Bleeding Disorders (NCT01261936)

Eligibility criteria:
Inclusion Criteria:

          1. Age between 18 and 45 years;

          2. Ascertained diagnosis of one of the following inherited bleeding disorders:

               1. Von Willebrand Disease type 1, 2, 3 severe and moderate (VWF:RCo < 30 %),as
                  diagnosed following Italian guidelines [4]

               2. Glanzmann Thromboasthenia

               3. Congenital Coagulation Factor VII, II or X deficiency

               4. A and B Haemophilia Carriers (Factor VIII and IX <25%);

          3. Bleeding Severity score > 2

          4. Signing the consent form.

        Exclusion Criteria:

        1. Under continuous anti-hemorrhagic prophylaxis 2. Affected by an active cancer or
        anti-phospholipid antibodies syndrome 3. History of liver, kidney or endocrine disorders 4.
        Submucous uterine fibroids, uterine polyps or malignancy 5. Use of oral contraceptives or
        intrauterine devices in the past three months 6. Treatment with non-steroidal
        anti-inflammatory drugs

        -
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: mp3 vs Apatos in Post-extractive Sockets (NCT02644070)

Eligibility criteria:
Inclusion Criteria:

          -  18 years old or older

          -  requiring one single tooth extraction and subsequently an implant-supported
             restoration

          -  able to sign an informed consent form

        Exclusion Criteria:

          -  history of systemic diseases that would contraindicate oral surgical treatment;

          -  long-term non-steroidal anti-inflammatory drug therapy;

          -  lack of opposite occluding dentition in the area intended for extraction and
             subsequent implant placement;

          -  Oral biphosphonate therapy;

          -  absence of adjacent teeth;

          -  unwillingness to return for the follow-up examination;

          -  use of more than 10 cigarettes per day. Subjects smoking less than 10 cigarettes per
             day were requested to stop smoking before and after surgery; however, their compliance
             could not be monitored.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Trial to Evaluate the Efficacy and Safety of a New Full Length Recombinant Human FVIII for Hemophilia A (NCT01029340)

Eligibility criteria:
Inclusion Criteria:

          -  Male, aged 12 to 65 years

          -  Severe hemophilia A defined as < 1% FVIII:C

          -  >/= 150 days of previous treatment with FVIII in lifetime

          -  Currently receiving on-demand or any type of prophylaxis treatment regimen with any
             FVIII product

          -  No history of or current FVIII inhibitors

        Exclusion Criteria:

          -  Presence of another bleeding disease that is different from hemophilia A (e.g., von
             Willebrand disease, hemophilia B)

          -  Low platelet count, abnormal kidney function, or liver disease

          -  Received treatment with immune suppressing drugs within the last 3 months prior or
             requires treatment during the study. (Some drugs for hepatitis C, Human
             immunodeficiency virus (HIV), and steroids are allowed)

          -  Receiving or has received other experimental drugs within 3 months prior to study
             entry

          -  Allergy to Factor VIII or hamsters or mouse protein
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Low-vision Rehabilitation Program for Low-vision Patients and Care Givers (NCT03166072)

Eligibility criteria:
Inclusion Criteria:

          -  at least 50 years of age

          -  has low-vision,

          -  deemed competent such as no language issues or communication barriers, no
             self-reported or physician diagnosed mental health disorder besides having depressive
             and anxiety symptoms,

          -  have sufficient hearing to be able to follow verbal instructions and able to sit
             without physical discomfort for 30 minutes

          -  willing and able to attend 4 initial ASTM training sessions and at least 75% of
             weekly, bi-weekly and monthly follow up sessions,

          -  willing to dedicate 20 minutes twice per day to ASTM practice at their own home.

        Exclusion Criteria:

          -  actively suicidal as per self-report (scoring 2 or more on item 9 of the Patient
             Health Questionnaire (PHQ-9) or on assessment by the physician,

          -  currently participating in other similar studies

          -  currently practicing any type of formal meditation regularly
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient description (patient's own words): I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Does the patient match the trial criteria? Entailment
Clinical trial: Inflammatory Aspects of Glucose in Hyperlipidemia and Diabetes (NCT02130505)

Eligibility criteria:
Inclusion Criteria:

          -  Provide written informed consent

          -  Aged 45-65 years

          -  BMI < 35 kg/m2

        Exclusion Criteria:

          -  Emotionally and intellectually not capable to decide about participation in the study
             and the consequences of participation. Subjects who are not able to understand the
             patient information

          -  Diabetes mellitus treated with oral antidiabetic medicine

          -  Type 1 diabetes mellitus

          -  Peripheral artery and/or coronary disease

          -  Untreated hypertension

          -  Alcohol use > 2 units/day

          -  Aberrations in kidney, liver and thyroid function

          -  Use of any experimental medication within 6 months of the study

          -  The use of immunosuppressive drugs
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of Syncope,Its Diagnosis, Treatment, Outcome and Prognosis (NCT00764985)

Eligibility criteria:
Inclusion Criteria:

          -  All adult patients (age 18 or older) admitted with syncope or near-syncope

        Exclusion Criteria:

          -  Patients who do not speak/read the language of the consent form

          -  Prisoners

          -  Patients who are of altered mental status or had head trauma

          -  Refusal or inability to sign consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: New Strategies of Genetic Study of Patients With Oculocutaneous Albinism (NCT04068961)

Eligibility criteria:
Inclusion Criteria:

        -Oculocutaneous albinism (diagnosis validated by a clinician at the initial genetic
        consultation and did not show mutations of the TYR, OCA2, TYRP1, SLC45A2 genes)

        Exclusion Criteria:

        None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? Entailment
Clinical trial: Retroperitoneal Ligation of Uterine Artery in Total Laparoscopic Hysterectomy for Enlarged Uterus (NCT03101098)

Eligibility criteria:
Inclusion Criteria:

          -  absence of pregnancy at the time of presentation

          -  uterine volume between 12 and 18 weeks of gestation by pelvic examination

          -  appropriate medical status for laparoscopic surgery (American Society of
             Anesthesiologists Physical Status classification 1 or 2)

        Exclusion Criteria:

          -  any suggestion of malignant uterine or adnexal diseases

          -  any major medical comorbidities or psychiatric illnesses, which could affect follow-up
             and/or compliance

          -  an inability to understand and provide written informed consent.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment