Clinical trial: Effect of Lithium Carbonate on Low-Dose Radioiodine Therapy in Early Thyroid Cancer (NCT00251316)

Eligibility criteria:
-  INCLUSION CRITERIA

               1. Patients older than 16 years with well-differentiated papillary or follicular
                  thyroid cancer stage I or II, according to the NTCTCS classification at time of
                  surgery

               2. Patients younger than 45 years with any size of primary papillary or follicular
                  tumor

               3. Patients older than 45 years with:

                    1. primary papillary tumor less than 4 cm or

                    2. primary follicular tumor less than 1 cm

          -  EXCLUSION CRITERIA

               1. Patients with postsurgical thyroid remnant more than 5 g

               2. Patients with distant metastases

               3. Patients above 45 years of age having:

                    1. known cervical lymph nodes metastases

                    2. microscopic multifocal follicular cancer

                    3. microscopic extraglandular invasion of follicular cancer

                    4. gross extraglandular invasion of papillary or follicular cancer

               4. Patients with confirmed histological subtypes of well-differentiated thyroid
                  cancer such as Hurtle cell carcinoma, insular and tall cell variants of papillary
                  cancer.

               5. Pregnant or lactating women

               6. Patients with renal impairment defined as repeat serum creatinine concentrations
                  above 1.5 mg/dl on thyroid hormone

               7. Patients on chronic lithium therapy for psychiatric illness

               8. Patients with current unstable cardiovascular conditions

               9. Patients with severe chronic medical conditions (liver failure, severe
                  debilitation, dehydration, sodium depletion, any other cancer requiring therapy,
                  etc)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction