araag2/NLI4PR huggingface dataset:
Clinical trial: Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (NCT01793168)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of a rare disease, a disease of unknown prevalence, undiagnosed or an
             unaffected carrier of a rare/uncommon disease

        Exclusion Criteria:

          -  Diagnosis of a disease which is not rare
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Limb Cooling in Essential Tremor (NCT02067702)

Eligibility criteria:
Inclusion Criteria:

          -  Age range 18 to 95 years,

          -  Clinical diagnosis of essential tremor for at least a year,

          -  A +2 or worse action or kinetic tremor of one or both upper limbs involving at least
             the forearm and/or hand

        Exclusion Criteria:

          -  Dermatologic lesions in upper limbs (e.g. skin cancer, eczema, fresh or healing
             wounds, abrasions, acne, pustules, abscesses, or skin rash),

          -  Sensory loss in the upper limbs,

          -  Known history of sensitivity to cold (i.e., cold urticaria),

          -  Known peripheral vascular disease,

          -  Raynaud's phenomenon,

          -  Scleroderma

        Healthy normal controls will be enrolled through advertisements. All controls will be
        examined to ensure that they are neurologically healthy.

        The exclusion criteria for controls will remain same as those for patient subjects.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 95 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Monitored Breathing Awareness Therapy for Insomnia Disorder in Older Adults-2 (NCT03187340)

Eligibility criteria:
Inclusion Criteria: 1) Sleep onset latency > 30 min for at least 3 nights per week

        Exclusion Criteria: 1) Unable to perform tests due to inability to communicate
        verbally/blindness, inability to write and read in English (the study questionnaires are in
        English and do not exist in validated form for other languages). 2) Cognitive impairment;
        cognitively impaired patients may not be able to comply with the protocol). 3) History of a
        diagnosed non-insomnia sleep disorder, such as sleep apnea or circadian rhythm disorder 4)
        Upper extremity motor impairment that would preclude MBAT therapy (e.g., quadriplegia).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? Contradiction
Clinical trial: Supporting the Health and Well-being of Children With Intellectual and Developmental Disability During COVID-19 Pandemic (NCT04565509)

Eligibility criteria:
Inclusion Criteria:

          -  Students enrolled in the St. Louis Special School District.

          -  Teachers/Staff working at the 6 St. Louis Special Schools dedicated to teaching
             children with IDD.

        or

          -  Parents/ of students, teachers and/or staff employed by the St. Louis Special School
             District or Kennedy Krieger Institute schools in Maryland or

          -  Families, teachers, and staff of the 67 University Centers for Excellence in
             Developmental Disabilities (UCEDD) which is sponsored by the Association of University
             Centers for Disability (AUCD).

        Exclusion Criteria:

          -  Members of the research team will not be eligible to participate in the focus groups.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Dynamic Neck Function During Gait in Patients With Dizziness (NCT04626544)

Eligibility criteria:
Inclusion Criteria:

        Locally referred Patients to an ear-nose-and throat (ENT) clinic at an University Hospital
        for dizziness symptoms.

        Exclusion Criteria:

        Any severe neurologic or orthopedic disease affecting gait.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 67 Years

Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment
Clinical trial: Spermatogonial Stem Cells in Azoospermic Patients: a Comparison Between Obstructive and Non-obstructive Azoospermia (NCT01178463)

Eligibility criteria:
Inclusion Criteria:

          -  Azoospermic patients

        Exclusion Criteria:

          -  Patients with sperm cells
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Impact of Yoga on Blood Pressure, Quality of Life and Stress in Patients With Hypertension (NCT01984593)

Eligibility criteria:
Inclusion Criteria:

          -  30-80 years old

          -  Diagnosed with hypertension since at least one year

          -  Blood pressure 130-160 mm Hg systolic and/or 85-100 diastolic at the last blood
             pressure control by doctor or nurse.

          -  Blood pressure within inclusion- and exclusion-limits at baseline control

        Exclusion Criteria:

          -  Blood pressure outside the range of 120-180 systolic and 80-110 diastolic at the last
             blood pressure control or at baseline control.

          -  Medical adjustments regarding hypertension within 4 weeks prior to begin of study.

          -  Expected inability to understand instructions about yoga exercises (e.g dementia and
             mental retardation) or physical or psychical inability to carry out yoga exercises
             (e.g severe physical or psychical handicap).

          -  Need for interpreter. Linguistic/language difficulties
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Gene Associations and Infertility (NCT01223092)

Eligibility criteria:
Inclusion Criteria:

          -  all patients undergoing fertility care

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient description (patient's own words): I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy Study of Tissucol/Tisseel Fibrin Sealant to Treat Inguinal Hernia (NCT00306839)

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent obtained from the subject prior to participation in the study

          -  Active males over the age of 18 years and below 80 years

          -  Experiencing an uncomplicated unilateral primary inguinal hernia or experiencing an
             uncomplicated bilateral hernia provided that only one hernia is operated during the 12
             months of study follow-up

          -  Subjects eligible for elective inguinal hernia repair using Lichtenstein technique.

        Exclusion Criteria:

          -  Recurrent, scrotal, incarcerated or femoral hernias

          -  Hernia types L3 and M3 according the EHS classification

          -  BMI equal or more than 35

          -  Concomitant abdominal surgery

          -  Ongoing long term analgesic or steroid treatment

          -  Patients under Clopidogrel or Warfarin (can be switched to LMW sub-cutaneous heparin)

          -  Known abuse of alcohol or drugs

          -  Liver cirrhosis (Child C)

          -  Previous treatment or Hypersensitivity to bovine aprotinin

          -  Known immunodeficiency

          -  Severely compromised physical or psychological health, that in the investigator's
             opinion will affect patient compliance

          -  Concurrently participating in another clinical trial and having received another
             investigational drug or device within the last 30 days
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: New Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis (NCT04691011)

Eligibility criteria:
Inclusion Criteria:

          -  Patients will be adults with a diagnosis of ALS.

          -  Healthy controls will also be recruited and will be age- and gender-matched to
             patients.

          -  Patients able to undergo a brain MRI for approximately an hour.

        Exclusion Criteria:

          -  Subjects with other psychiatric or CNS or PNS diseases.

          -  Subjects ineligible for MRI investigation due to a pacemaker or other metallic foreign
             body, or significant claustrophobia that could affect the ability to have an MRI scan.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment