araag2/NLI4PR huggingface dataset:
Clinical trial: Mirena or Conventional Medical Treatment for Menorrhagia (NCT00864136)

Eligibility criteria:
Inclusion Criteria:

          -  Women between the ages of 18-45 (inclusive) not intending to get pregnant during the
             next year

          -  Women complaining of heavy menstrual bleeding over several consecutive cycles

          -  Women without structural or histological abnormality of the uterus, or with fibroids
             less than 3 cm in diameter which are causing no distortion of the uterine cavity
             (eligible for pharmaceutical treatment according to the NICE guideline 2007)

          -  Informed consent (where required by laws or regulations)

        Exclusion Criteria:

          -  The contraindications and warnings of the respective Summary of Product
             Characteristics (Mirena, combined oral contraceptives, oral/injectable progestogens,
             non-steroidal anti-inflammatory drug, or anti-fibrinolytic agent) must be followed.

          -  Women taking hormone replacement therapy

          -  Women with symptoms such as intermenstrual or post-coital bleeding, unless an
             endometrial biopsy has been performed and pathology excluded

          -  Women with fibroids that are palpable abdominally or who have intra-cavity fibroids
             and/or whose uterine length as measured at ultrasound or hysteroscopy is greater than
             12 cm (NICE guideline 2007)

          -  Women on anticoagulative therapy or other treatment (including e.g. Copper IUD use)
             known to cause menorrhagia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: A Nurse Led Patient Management Programme to Improve Outcomes in Gout (NCT03345186)

Eligibility criteria:
Inclusion Criteria:

          -  Proven diagnosis of gout according to aspiration of Monosodium urate (MSU) crystals or
             positive dual energy computer tomography (DECT) or American college of rheumatology
             (ACR) criteria 2015 fulfilled (1)

          -  written informed consent

          -  age >=18 years

          -  ability and willingness to follow a fixed outpatient programme as judged by the
             investigator

          -  indication for urate-lowering therapy (ULT)

          -  In case of established disease and intercritical gout a SUA level over 360 umol per
             liter is mandatory.

        Exclusion Criteria:

          -  informed consent not obtained

          -  age <18 years

          -  inability or unwillingness to follow a fixed outpatient programme as judged by the
             investigator

          -  no definite diagnosis of Gout

          -  no indication for ULT or contraindications against ULT

          -  in case of established disease and intercritical gout a SUA level <360 umol per liter
             is an exclusion criterion

          -  Pregnant or breastfeeding women can´t participate.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Entailment
Clinical trial: Radial Nerve Block for Treatment of Tennis Elbow (NCT03262623)

Eligibility criteria:
Inclusion Criteria:

          -  18 years and above

          -  presenting with refractory elbow pain

        Exclusion Criteria:

        patients with:

          -  osteoarthritis,

          -  rheumatoid arthritis,

          -  olecranon bursitis,

          -  radial nerve entrapment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Prospective Observational Study of the Clinical Performance of Zarin in Madagascar (NCT01200576)

Eligibility criteria:
Inclusion Criteria:

          -  be a participant of the MSM service evaluation and continue using Zarin at 3 months

          -  agree at the time of Zarin insertion to be contacted regarding an opportunity to
             participate in more research related to the implant

        Exclusion Criteria:

        -
Female
Accepts Healthy Volunteers



Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Treatment With a Spinal Orthosis Compared to Equipment Group Training and a Control Group (NCT03263585)

Eligibility criteria:
Inclusion Criteria

          -  Woman aged ≥ 60 years

          -  Osteoporosis according to DXA (Dual X-Ray Absorptiometry) hip (femoral neck or total
             hip) or lumbar spine.

          -  Back pain.

        Exclusion Criteria

          -  Diagnosed symptomatic spinal stenosis

          -  Difficulty to participate in the activities included in the study due to health
             problems.

          -  Difficulty to participate in equipment training group.

          -  Inability to be able to complete wearing the spinal orthosis.

          -  Language difficulties

          -  Cognitive difficulties

          -  Visual problems
Female
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Long-term Effect of Electromagnetic Field in Treatment of Patients With Osteopenia or Osteoporosis (NCT04608162)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with a T-scores of ≤ ˗1.5, all patients received the same medical treatment
             for osteoporosis and the same average blood glucose level, sufficient ability to
             understand the nature and potential risks of the study.

        Exclusion Criteria:

          -  Diabetes mellitus, ischemic heart disease, arrhythmia, uncontrolled thyroid disease,
             cardiac pacemaker, tuberculosis, neuropsychiatric disorders (dementia, cerebrovascular
             disease, alcohol abuse, severe depression, panic disorder, bipolar disorder, or
             psychosis), and malignancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: True Short Esophagus in Gastroesophageal Reflux Disease (NCT03848494)

Eligibility criteria:
Inclusion Criteria:

          -  Patients submitted to primary minimally invasive surgery for gastroesophageal reflux
             diseases or hiatus hernia.

          -  Age > 18 years.

        Exclusion Criteria:

          -  Patients already submitted to minimally invasive surgery for gastroesophageal reflux
             diseases or hiatus hernia for recurrence of the disease.

          -  Patients submitted to open surgery for gastroesophageal reflux diseases or hiatus
             hernia.

          -  Patients affected by other esophageal diseases.

          -  Age < 18 years.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Prevalence of Obstructive Sleep Apnea Syndrome in Sarcoidosis and Impact of CPAP Treatment on Associated Fatigue Status (NCT03926832)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with a definite diagnosis of sarcoidosis according to international ATS and
             WASOG guideline

        Exclusion Criteria:

          -  Ongoing CPAP treatment

          -  Psychiatric disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? Entailment
Clinical trial: Hormonal Regulation of Puberty and Fertility (NCT01511588)

Eligibility criteria:
-  INCLUSION CRITERIA:

        Since hypogonadotropic hypogonadism is a rare condition, with an incidence of 1/10,000 to
        1/86,000 for isolated GnRH deficiency (34, 35), this protocol remains open to enrollment so
        that we may study all subjects that are both qualified and interested in participating.

        Males or females who are greater than or equal to 14 years old with clinical findings of HH
        as outlined above will be included. In certain circumstances, a patient under the age of 14
        years may be considered for baseline evaluation if there is sufficient evidence suggestive
        of HH, such as any two of the following: anosmia, history of cryptorchidism or
        microphallus.

        EXCLUSION CRITERIA:

        -Because HH represents a spectrum, where associated clinical findings may provide
        phenotypic clues to the assessment of inheritability and underlying physiology, exclusion
        criteria are very limited:

          -  Patients who have additional pituitary deficiencies, effectively ruling out isolated
             GnRH deficiency, whether these deficiencies are congenital or acquired (e.g. secondary
             to malignancy, infection, or irradiation).

          -  Patients who are taking medications known to cause HH, such as corticosteroids or
             continuous opiate administration.

          -  Pregnancy or lactation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.


Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment