araag2/NLI4PR huggingface dataset:
Clinical trial: The Impact of Medical Clowning on Pain and Stress Level in Pediatric Patients Undergoing Hernia Repair Surgery LAUGH Study. (NCT01622218)

Eligibility criteria:
Inclusion Criteria:

          -  ages 4-10 years old

          -  undergoing elective umbilical or inguinal hernia repair surgery

          -  ASA Physical Status = 1

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 10 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Randomized Double-blind Controlled Trial of Use of Dydrogesterone in Threatened Miscarriage (NCT02128685)

Eligibility criteria:
Inclusion Criteria:

          -  Age of women from 18-40 years at the time of recruitment (not beyond 40th birthday)

          -  Absence of fever

          -  Gestation less than 12 completed weeks as defined by pelvic ultrasound

          -  Presence of intrauterine gestational sac(s) if an urine pregnancy test is first
             positive within past 2 weeks

          -  Presence of intrauterine fetus(es) with crown-rump length of <7mm and no fetal
             pulsation, or presence of intrauterine fetus(es) with positive fetal heart pulsation
             confirmed on pelvic scanning

        Exclusion Criteria:

          -  Age of women >40 years at the time of recruitment

          -  History of recurrent miscarriage defined as at least three consecutive spontaneous
             miscarriages

          -  History of known parental chromosomal abnormalities

          -  Heavy vaginal bleeding requiring surgical intervention

          -  Severe abdominal pain requiring surgical intervention

          -  Absence of cardiac pulsation in a fetal pole with crown-rump length of >=7mm on
             transvaginal scanning

          -  Use of hCG or progesterone treatment for threatened miscarriage prior to recruitment
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Psychological Impact of Predicting Early Pregnancy Outcomes in Women With Pregnancy of Uncertain Viability (NCT03264170)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years+

          -  Diagnosis of IPUVI on initial ultrasound

        Exclusion Criteria:

          -  Current mental health condition (anxiety, depression, eating disorder). The condition
             will be considered current if it has required one or more consultations with a medical
             professional (including a psychologist) over the past 6 months (women with past mental
             health condition will not be excluded)

          -  The patient is planning a termination

          -  Multiple order pregnancies

          -  Women who in the opinion of the researcher by virtue of language or learning
             impairment would be unable to give fully informed consent to the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Entailment
Clinical trial: Menstrual Cycle Symptom Tracking (NCT04756739)

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  Aged 18 years and over

          -  Regular menstrual cycles

          -  Owns a compatible smart phone i.e. iPhones® and AndroidTM phones equipped with
             Bluetooth® 4.0/BLE

          -  Willing to use their own smartphone for the duration of this study and to download and
             install the study app

          -  Willing to give informed consent

        Exclusion Criteria:

          -  Currently trying to conceive

          -  Currently or recently pregnant or breastfeeding

          -  Taking any treatment which may affect the menstrual cycle (e.g. contraceptive pill,
             fertility medications or hormone replacement therapy)

          -  Taking or undergoing any other medical treatment for fertility such as ovulation
             drugs, artificial insemination and assisted fertility such as In vitro fertilization
             (IVF) or Intracytoplasmic sperm injection (ICSI)

          -  Has abnormal liver or kidney function

          -  Taking antibiotics containing tetracycline

          -  Taking clomiphene citrate or other ovulation induction drugs
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of Cyclosporine in the Treatment of Dry Eye Syndrome (ST-603-005) (NCT00502073)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of moderate to severe dry eye syndrome with or without Sjogren's syndrome or
             other autoimmune disease

        Exclusion Criteria:

          -  Intraocular or refractive surgery in the study eye within 3 months prior to study
             start

          -  Unwilling to discontinue use of contact lenses during the run-in and duration of the
             study

          -  Pregnancy or lactation
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Knee Osteoarthritis Care: A Quality Improvement Intervention in Physiotherapists (NCT02177162)

Eligibility criteria:
Inclusion Criteria:

          -  patients with knee osteoarthritis, treated by a participating physiotherapist within a
             predefined period

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Oral Procaterol on Postinfectious Persistent Cough (NCT02349919)

Eligibility criteria:
Inclusion Criteria:

          1. Having persistent cough that lasts longer than 3 weeks following URTI

          2. Currently being a non-smoker

          3. Having normal spirometry (FEV1>or= 80% predicted)

          4. Obtain consent form

        Exclusion Criteria:

          1. Having cough more than 8 weeks

          2. Having history of allergic or intolerance to β2 agonist

          3. Having diagnosis of asthma by physicians

          4. Presence of wheeze or rhonchi on physical examination

          5. Having radiographic evidence of pneumonia, tuberculosis or sinusitis

          6. Having significant gastroesophageal reflux symptoms suggested by GERD-Q questionnaire
             (GERD-Q score > 8)

          7. Currently taking ACE-inhibitor

          8. Being active smokers

          9. Refuse to participate in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Depressive Symptoms and Subjective Stress in the Course of the Menstrual Cycle - an Ambulatory Assessment Study. (NCT04086316)

Eligibility criteria:
For participants with major depressive episode:

        Inclusion criteria:

          -  female sex

          -  current diagnosis of a major depression episode

          -  minimum age of 18 years

          -  regular menstrual cycle.

        Exclusion criteria:

          -  Pregnancy less than one year ago;

          -  women who are breastfeeding;

          -  bipolar disorder;

          -  acute suicidal tendencies;

          -  schizophrenic disorders (F20-29);

          -  substance use disorders

          -  psychotropic drugs in the last six months;

          -  chronic somatic diseases.

        For participants without major depressive episode:

        Inclusion criteria:

          -  female sex;

          -  minimum age of 18 years;

          -  regular menstrual cycle.

        Exclusion criteria:

          -  current or lifetime mental disorder;

          -  pregnancy less than one year ago;

          -  women who are breastfeeding;

          -  psychotropic drugs in the last six months;

          -  chronic somatic diseases.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome (NCT00294593)

Eligibility criteria:
Inclusion Criteria:

          -  Down syndrome without mosaicism

          -  age 3 to 30 months

          -  weight over 4 kg

          -  possible assessment by the revised Brunet-Lezine scale

        Exclusion Criteria:

          -  history of leukemia

          -  West syndrome or non-stable epilepsy

          -  non-stable thyroxin treatment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.
Subject must be at most 30 Months

Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy And Safety Of Thoracoscopic Cryobiopsy In Patients With Undiagnosed Exudative Pleural Effusion (NCT04761003)

Eligibility criteria:
Inclusion Criteria:

          -  patients diagnosed as exudative pleural effusion according to Light criteria .informed
             written consents were taken from all patients enrolled in the study

        Exclusion Criteria:

          -  patients who refused participation ,patients unfit for medical thoracoscopy (MT) will
             be excluded from the study such as:Uncooperative patient ,Severe uncorrected hypoxemia
             in spite of continuous oxygen administration, because it's necessary to keep oxygen
             saturation above 90 % during procedure ,patients who could not tolerate the lateral
             decubitus position for a period long adequate to do the thoracoscopy, unstable
             cardiovascular or hemodynamic condition, uncorrected Coagulation defects and small
             pleural space
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment