araag2/NLI4PR huggingface dataset:
Clinical trial: Weight Loss for Obese Individuals With Gout (NCT03664167)

Eligibility criteria:
Inclusion Criteria:

          -  a diagnosis of gouty arthritis per expert opinion and the ACR/EULAR 2015 criteria for
             gout.

          -  have had at least one self-reported flare in the last 12 months

          -  BMI >30kg/m2

          -  >18 years of age

        Exclusion Criteria:

          -  pregnant

          -  hisotry or suspicion of drug abuse within the past 5 years

          -  Active muscle disease, cancer, previous kidney disease, and/or fatty liver

          -  An estimated creatinine clearance <30 mL/min calculated by the Cockcroft-Gault formula
             using ideal body weight.

          -  An investigational therapy within 8 weeks or 5 half-lives (whichever is longer) prior
             to the screening visit.

          -  Any other medical or psychological condition which, in the opinion of the investigator
             and/or medical monitor, might create undue risk to the patient or interfere with the
             patient's ability to comply with the protocol requirements, or to complete the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Safety and Efficacy of AFQ056 in Adult Patients With Fragile X Syndrome (NCT01253629)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Fragile X Syndrome, who are at least moderately ill based on a Clinical
             Global Impression Severity score of at least 4 and have qualifying scores on the ABC-C
             and IQ test at Visit 1

        Exclusion Criteria:

          -  Advanced, severe or unstable disease that may interfere with the study outcome
             evaluations

          -  Cancer within the past 5 years, other than localized skin cancer

          -  Current treatment with more than two psychoactive medications, excluding
             anti-epileptics

          -  History of severe self-injurious behavior

        Other protocol-defined inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Clinical Trial of a Vitamin/Nutriceutical Formulation for Alzheimer's Disease (NCT01320527)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Alzheimer's disease or Mild Cognitive Impairment

          -  must be able to swallow pills

        Exclusion Criteria:

          -  known or suspected bipolar disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of Memantine on Functional Outcomes and Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis (ALS) (NCT00409721)

Eligibility criteria:
Inclusion Criteria:

          -  El Escorial Classification of laboratory supported probable, probable,or definite ALS

          -  Age 18 - 80 years,

          -  ALS symptoms for no more than 3 years,

          -  FVC greater than or equal to 60% predicted,

          -  Riluzole naïve or have been on a stable dose of Riluzole for at least 2 months,

          -  Patients must have the ability to attend monthly study visits in Edmonton or Calgary,
             Alberta

        Exclusion Criteria:

          -  Presence of significant sensory abnormalities, dementia, other neurologic diseases,
             uncompensated medical illness and psychiatric illness

          -  Female patients who are breastfeeding

          -  Use of concurrent investigational drugs,

          -  Patient unlikely to comply with study requirements

          -  Poor adherence to study protocol during run-in phase
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Serum IL-17 Correlated With Inflammatory Changes in Osteoarthritis and Rheumatoid Arthritis (NCT04474912)

Eligibility criteria:
Inclusion Criteria:

          -  A patient is considered having definite RA if he/she scores at least 6 points in the
             established classification system

          -  A patient is considered having Hand OA if he /she Hand pain, aching, or stiffness plus
             3 or 4 of hard tissue enlargement of 2 or more of 10 selected joints or hard tissue
             enlargement of 2 or more DIP joints or fewer than 3 swollen MCP joints, or deformity
             of at least 1 of 10 selected joints which are are the second and third distal
             interphalangeal (DIP), the second and third proximal interphalangeal, and the first
             carpometacarpal joints of both hands

        Exclusion Criteria:

          -  Any subject with liver diseases, coronary artery diseases, kidney diseases or other
             inflammatory conditions was excluded from the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Gastric Cancer Registry for Epidemiology and Molecular Risk Factor (NCT03046745)

Eligibility criteria:
Inclusion Criteria:

          -  The patients who were diagnosed of primary gastric adenocarcinoma and drew up
             agreement for understanding and enrollment of this study.

        Exclusion Criteria:

          -  Being treated (surgery, endoscopic resection and chemoradiation) after the diagnosis
             of gastric cancer; metastatic gastric cancer; refusal to participation of this study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of Resistance Training in Body Composition and Body Image Perception of Women Throughout the Menstrual Cycle (NCT04038463)

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  Sedentary or Active

          -  18.5-34.9 kg/m2 BMI

          -  Normal menstrual cycle defined as 28 to 30 days and a duration of 3 to 7 days

          -  Age range is 18-45 years old

          -  The inclusion of other participants may alter the results as an increase in body fat
             has been linked to known changes in different hormonal levels and those changes might
             influence substrate utilization

          -  Changes in the hormonal status of pre-menopausal women may appear without symptoms

          -  Younger females also display variations in their hormones since they are going through
             the process of development

        Exclusion Criteria:

          -  Previous physiological and mental health history

          -  Pregnant females

          -  Males

          -  Irregular menstrual cycle, menstrual dysfunction or unusual sex hormone levels

          -  Musculoskeletal injuries

          -  Contraceptives, a medication that alters hormonal or cardio-respiratory responses

          -  Pre-menopausal symptoms

          -  On moderate to high-intensity exercise regime more than 2 days/week
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Targeted Dose Finding of Canakinumab (ACZ885) for Management of Acute Flare in Refractory or Contraindicated Gout Patients (NCT00798369)

Eligibility criteria:
Inclusion Criteria:

          -  History of at least 1 gout flare prior to the Screening Visit

          -  Meeting the American College of Rheumatology (ACR) 1977 preliminary criteria for the
             classification of acute arthritis of primary gout.

          -  Presence of acute gout flare for no longer than 5 days.

          -  Baseline pain intensity > or = to 50 mm on the 0-100 mm VAS.

          -  Contraindicated for, intolerant or unresponsive to NSAIDs, colchicine or both.

        Exclusion Criteria:

          -  Rheumatoid arthritis, evidence/suspicion of infectious/septic arthritis, or other
             acute inflammatory arthritis.

          -  Presence of severe renal function impairment

          -  Contraindication to intramuscular injection

          -  Known presence or suspicion of active or recurrent bacterial, fungal or viral
             infection at the time of enrollment

          -  Evidence of active pulmonary disease

          -  Live vaccinations within 3 months prior to the start of the study

          -  Use of forbidden therapy

        Other protocol-defined inclusion/exclusion criteria applied
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Von Willebrand Disease in the Netherlands (NCT03521583)

Eligibility criteria:
Inclusion Criteria:

          -  Historically lowest VWF:Ag and/or VWF:RCo and/or VWF:CB ≤ 0.30 IU/mL and/or FVIII:C ≤
             0.40 IU/mL

          -  Treatment at a Hemophilia treatment center in the Netherlands

          -  All types of VWD

          -  All ages

        Exclusion Criteria:

        - Other known bleeding disorders present.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment