araag2/NLI4PR huggingface dataset:
Clinical trial: Therapeutic Potential for Aldosterone Inhibition in Duchenne Muscular Dystrophy (NCT02354352)

Eligibility criteria:
Inclusion Criteria:

          -  Boys age ≥7 years with DMD confirmed clinically and by mutation analysis able to
             undergo cardiac magnetic resonance (CMR) without sedation

          -  LV EF ≥45% (+/-5%) by clinically-acquired echocardiography, nuclear scan or cardiac
             MRI done within 2 weeks of enrollment

        Exclusion Criteria:

          -  Non-MR compatible implants

          -  Severe claustrophobia

          -  Gadolinium contrast allergy

          -  Kidney disease

          -  Prior use of or allergy to aldosterone antagonist

          -  Use of other investigational therapy.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: CoViD-19 Patient in Reims University Hospital in March to April 2020 (NCT04553575)

Eligibility criteria:
Inclusion Criteria:

          -  Patient hospitalized for CoViD-19 infection during the health crisis, in a short-stay
             service of Reims University Hospital and included in Covid-19 Cohort

          -  Age > 18 years

          -  Patient who benefit from the national health insurance coverage

          -  patient agree for participation (consent form signed)

        Exclusion Criteria:

          -  Patient protected by law
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effects of Direct Context Reactivation During Sleep on Memory (NCT04702152)

Eligibility criteria:
Inclusion Criteria:

        ---

        Exclusion Criteria:

        Participants with a history of neurological disorders or of sleep disorders will be
        excluded.

        Participants who do not believe they would be able to fall asleep in the lab will be
        excluded.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? Contradiction
Clinical trial: Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis (NCT02759393)

Eligibility criteria:
Inclusion Criteria:

          -  Eligible participants included patients ≥20 years with either overweight (BMI of 25-30
             kg/m2) or obese (BMI > 30 kg/m2), who had undergone panendoscopy due to typical
             clinical symptoms of either acid regurgitation, heartburn sensation, or both. By the
             results of panendoscopy, patients with the severity of grade A or B esophageal reflux,
             according to the Los Angeles classification, are enrolled.

        Exclusion Criteria:

          -  Patients are excluded if they have taken antisecretory agents, including histamine-2
             receptor antagonist and PPI, within two weeks prior to the panendoscopy. The following
             conditions are also excluded: the presence of peptic ulcers, pregnancy, major medical
             problems (including hypertension, liver cirrhosis, COPD, asthma, renal failure and
             congestive heart failure), or previous gastric surgery. Patients who have an allergy
             history to dexlansoprazole or lansoprazole are also excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 95 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Clinical Decision Support System Based on Non-invasive Tele-monitoring of COVID-19 Patients (NCT04802018)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of SARS-CoV-2 disease, detected by PCR or antigen test, performed
             72 h prior to patient inclusion in the study.

          -  Acceptance to sign the informed consent document.

          -  Possession of a Smartphone or Tablet with Internet connection.

          -  Possession of mental faculties to participate in the study.

        Exclusion Criteria:

          -  Age below the age of health majority (16 years).

          -  Lack of digital skills to use the Home App.

          -  Cognitive impairment that prevents the patient from participating in the study.

          -  Disabling pathology of the upper limb.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Hippocampal Complex Volume and Memory Dysfunction in Cushing's Syndrome (NCT00004326)

Eligibility criteria:
PROTOCOL ENTRY CRITERIA:

          -  Adults and teenagers with untreated, spontaneous active Cushing's syndrome

          -  Diagnosis verified at the University of Michigan Medical Center, including the
             following: Excessive cortisol secretion measured by urinary-free cortisol, cortisol
             secretion rate, and plasma cortisol level

          -  Lack of normal circadian cortisol secretion and failure to suppress following 2 mg of
             dexamethasone
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluation of Patients With Known or Suspected Heart Disease (NCT00001313)

Eligibility criteria:
-  INCLUSION CRITERIA:

        The following is a representative list of the types of patient presentations and potential
        diagnoses eligible for this protocol:

          1. Coronary artery disease with angina or inducible myocardial ischemia as determined by
             noninvasive testing.

          2. Cardiomyopathies including congestive phenotypes.

          3. Peripheral artery disease with intermittent claudication or limb-threatening ischemia.

          4. Renovascular disease with uncontrolled hypertension, intermittent pulmonary edema, or
             evidence of ischemic nephropathy.

          5. Upper extremity peripheral artery disease.

          6. Diabetes with heart failure.

          7. Pulmonary hypertension.

        EXCLUSION CRITERIA:

        Pregnancy, for those patients who require catheterization-based diagnostics.

        Inability to provide informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: Deep braIn Stimulation for Tremor TractographIC Versus Traditional (NCT02491554)

Eligibility criteria:
Inclusion Criteria:

          1. Male or female patients aged ≥ 25 and ≤ 80 years

          2. Patients with Essential Tremor according to the criteria of the consensus statement of
             the movement disorders society (Deuschl et al. 1998) are included with a medical
             treatment resistant and disabling postural and/or intentional tremor.

          3. FTMTRS to be completed within 42 days prior surgery

          4. Stable tremor medication for at least 3 months prior inclusion

          5. Written informed consent

        Exclusion Criteria:

          1. Major Depression with suicidal thoughts or suicidal thoughts in history

          2. Dementia (Mattis Dementia Rating Score ≤ 130)

          3. Acute psychosis

          4. Patient incapability

          5. Nursing care at home

          6. Surgical contraindications

          7. Medications that are likely to cause interactions in the opinion of the investigator

          8. Known or persistent abuse of medication, drugs or alcohol

          9. Persons who are in a relationship of dependence/employment with the sponsor or the
             investigator

         10. Fertile women not using adequate contraceptive methods: female condoms, diaphragm or
             coil, each used in combination with spermicides; intra-uterine device; hormonal
             contraception in combination with a mechanical method of contraception;

         11. Current or planned pregnancy, nursing period
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Texture Analysis for Postmenopausal Osteoporosis (NCT00145977)

Eligibility criteria:
Inclusion Criteria:

          -  The study will enroll 40 postmenopausal women with a T score < -2 either at the lumbar
             spine or the femoral neck: 20 who decide to begin anti-resorptive therapy (treated
             group), and 20 women who decline such therapy (control group). We will attempt to
             match the patients and the controls for T score (within 0.3) and age (within 5 years).

          -  All study participants will be:

               -  at least 3 years past the last menstrual period,

               -  not on HRT, Raloxifene or calcitonin for at least 6 months.

        Exclusion Criteria:

          -  All study participants will not be on bisphosphonates during the previous 12 months.

          -  Women with secondary causes of osteoporosis will be excluded.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 59 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Investigating the Effects of Neuromobilization in Lateral Epicondylitis (NCT04219488)

Eligibility criteria:
Inclusion Criteria:

          -  Patients aged >18 years

          -  A symptom duration of >3 months

        Exclusion Criteria:

          -  Bilateral symptoms

          -  Rheumatologic diseases affecting the elbow and the wrist

          -  Musculoskeletal disorders due to connective tissue diseases

          -  Diffuse pain syndrome

          -  Cervical radiculopathy

          -  Nerve compression syndromes involving upper extremity

          -  Undergone surgery at the affected arm

          -  Received an LE treatment in the last 6 months

          -  An inability to perform the exercises
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction