Clinical trial: Measuring Gait And Self-Reported Pain In Patients With Osteoarthritis Of The Knee Using Placebo/Oxycodone/Celecoxib. (NCT00484718)

Eligibility criteria:
Inclusion Criteria:

          -  Subject has been taking an NSAID at least 15 of the past 30 days for index knee pain

          -  Grades 2 or 3 OA as defined by the Kellgren and Lawrence Grading System of the medial
             tibiofemoral joint (joint space narrowing in the medial compartment > lateral
             compartment as assessed by x-ray) using the Altman Atlas of OA7. This must be
             documented with a report from an x-ray of the study joint taken either at screening or
             within 1 year prior to screening

          -  Subject meets American College of Rheumatology (ACR) clinical classification criteria
             for osteoarthritis of the knee, defined by the following: Knee pain and at least 3 of
             the following: oAge >50 oMorning stiffness <30 minutes oCrepitus on active motion
             oBony tenderness oBony enlargement oNo palpable warmth of synovium.

        Exclusion Criteria:

          -  Subject has a documented history of an allergic reaction (hives, rash, etc.) or a
             clinically significant intolerance to celecoxib, sulfonamides, aspirin, or opioids
             including oxycodone

          -  Significant pain outside the index knee, including significant hip or back pain that
             can not be distinguished from OA pain or that interferes with ability to walk.
             (Patients with bilateral knee OA will be allowed into the study. The index knee should
             be defined as the more painful knee

          -  Predominantly patellofemoral knee osteoarthritis in the index knee as assessed by
             clinical examination

          -  Subject who are unable to discontinue all formulations of prior analgesics other than
             acetaminophen during the Washout Period of the study, or who are anticipated to be
             unable to discontinue rescue medication for 24 hours prior to the respective visits.
             (Low dose aspirin may be taken for cardiac prophylaxis

          -  Excessive signal knee joint laxity indicative of functional ligamentous deficiency
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment