araag2/NLI4PR huggingface dataset:
Clinical trial: Comparison of Cuff-Less Wrist Wearable Blood Pressure Device to Cuff Based Blood Pressure Measuring Devices (NCT04835857)

Eligibility criteria:
Inclusion Criteria:

          -  Health volunteers 18 years and above; equal numbers of males and females to address
             Sex As a Biological Variable (SABV); and in sinus rhythm.

          -  Agree to commit to participate in the current protocol.

          -  Provide written informed consent prior to any study procedures being performed (all
             subjects should be able to understand the informed consent form and any other
             documents that subjects are required to read).

        Exclusion Criteria:

          -  Unable or unwilling to provide informed consent

          -  Any other condition that would increase the risk of participation in the study in the
             opinion of the site Investigator.

          -  A difference of >10 mm Hg in left versus right arm oscillometric systolic BP.

          -  Upper extremity arteriovenous hemodialysis shunt.

          -  Wrist distortion or pain from arthritis.

          -  Prior trauma or surgery at the radial artery monitoring site.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: C-reactive Protein (CRP)-Guided Management Algorithm for Adults With Acute Cough (NCT00221351)

Eligibility criteria:
Inclusion Criteria:

          -  Adults (age > 18 years) seeking care for an acute respiratory illness (duration < 10
             days) in which cough is a chief complaint.

          -  Eligible patients will be required to have at least 1 symptom of acute respiratory
             tract infection (fever, night sweats, rhinorrhea, sinus congestion, myalgias).

        Exclusion Criteria:

          -  Previous (within 21 days) antibiotic treatment;

          -  immunodeficiency;

          -  cystic fibrosis;

          -  patient requiring immediate evaluation/management;

          -  inability to provide informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Lead-in Study to Collect Prospective Efficacy and Safety Data of Current FVIII Prophylaxis Replacement Therapy in Adult Hemophilia A Participants (NCT03876301)

Eligibility criteria:
Inclusion Criteria:

          1. Able and willing to provide written informed consent.

          2. Males ≥18 years of age.

          3. Clinically severe hemophilia A

          4. Previous exposure to FVIII therapy

          5. No prior history of hypersensitivity or anaphylaxis associated with an FVIII or
             intravenous immunoglobulin administration.

          6. No measurable inhibitor against FVIII

          7. Willing to participate and receive treatment in a future Spark hemophilia A gene
             therapy study.

        Exclusion Criteria:

          1. Documented active hepatitis B or C within the past 12 months of Screening

          2. Currently on antiviral therapy to treat hepatitis B or C;

          3. Documented significant liver disease within the past 6 months of Screening

          4. Have serological evidence of HIV-1 or HIV-2

          5. Anti-AAV-Spark 200 neutralizing titers ≥1:1

          6. Previously received SPK-8011;

          7. Previously dosed with any investigational or approved gene therapy product at any time
             or treated with an investigational drug within the last 12 weeks;

          8. Planned surgical procedure in the next 12 months requiring FVIII prophylactic
             treatment.

          9. Any history of chronic infection or other chronic disease, concurrent clinically
             significant major disease (such as liver abnormalities or type I diabetes) including
             active malignancy, except for non-melanoma skin cancer, any other condition or any
             other unspecified reasons that, in opinion of the Investigator or Sponsor, makes the
             participant unsuitable for participation and dosing in a future clinical study for
             Spark's hemophilia A gene therapy.

         10. Unable or unwilling to comply with the schedule of visits and/or study assessments
             described in the protocol.
Male

Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Portuguese Inguinal Hernia Cohort (PINE) Study (NCT04328597)

Eligibility criteria:
Inclusion Criteria:

          -  Elective inguinal hernia repair in a portuguese hospital

          -  Willing and able to consent and comply with the follow up protocol

        Exclusion Criteria:

          -  Urgent/emergent inguinal hernia repair
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: A Database Study to Estimate the Risk of Multiple Sclerosis Following Vaccination With Arepanrix™ in Manitoba, Canada (NCT02367222)

Eligibility criteria:
Inclusion Criteria:

          -  The entire population of Manitoba is considered for inclusion.

        Exclusion Criteria:

          -  Individuals less than or equal to 6 months of age;

          -  Having less than one year of insurance coverage before the enrolment period;

          -  Not registered with MH during the enrolment period;

          -  Physician or hospitalization records indicating a diagnosis of any demyelinating
             condition between 1971 (earliest year for which information is available) and the
             index date.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.


Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: Various Type of Genetic Events in Patients With Intellectual Disability (NCT02881333)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with developmental disabilities

          -  No etiologic diagnosis but suspected genetic cause

          -  Fragile X syndrome research negative

        Exclusion Criteria:

          -  Children born to consanguineous couples

          -  Diagnosis already established or suspected

          -  Identification of an independent etiology
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Association Study Between Periodontal Disease and Male Infertility (NCT01140945)

Eligibility criteria:
Inclusion Criteria:

          -  Consent to participate in study

        Exclusion Criteria:

          -  Systemic uncontrolled disease
Male

Subject must be at least 20 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Patient and Partner Perception After Remission of Cushing's Syndrome (NCT03607474)

Eligibility criteria:
Inclusion Criteria:

          -  Subject, male or female over 18

          -  Subject presenting a hypercortisolism in remission or controlled by a drug treatment
             for more than one year.

          -  Subject with a good understanding of the French language

          -  Non-institutionalized subject

          -  Subject whose informed consent could be obtained

        Exclusion Criteria:

          -  Minor subject or over 80 years

          -  Subject presenting hypercortisolism in remission for more than 20 years

          -  Major cognitive impairment that does not allow answering a questionnaire

          -  Genetic syndrome responsible for hypercortisolism

          -  Mixed adenoma whose corticotropic share is responsible for hypercortisolism

          -  Pituitary carcinoma

          -  Subject refusing to participate in the study

          -  Subject having no close

          -  Subject whose relative refuses to answer the questionnaires
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? Contradiction
Clinical trial: Risks and Outcomes Among COVID-19 Patients Admitted to Assiut University Hospitals. (NCT04860245)

Eligibility criteria:
Inclusion Criteria:

        - Cases aged 18 years and over. Cases diagnosed as COVID-19 by radiology or with positive
        PCR. Cases admitted to Assiut University Hospitals.

        Exclusion Criteria:

          -  Cases less than 18 years old. Cases diagnosed as COVID-19 and discharged from
             emergency department for Home Isolation. Cases express a dissent from the use of their
             data in this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 120 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effect of Lateral Wedge Insole for Knee Osteoarthritis Patient in Plantar Pressure, Quadriceps Thickness, Gait and Walking Speed (NCT04629040)

Eligibility criteria:
Inclusion Criteria:

          -  Knee osteoarthritis patients

          -  Medial knee pain

        Exclusion Criteria:

          -  Unable to walk independently

          -  Ambulation with device

          -  Any neurologic disease

          -  Rheumatoid arthritis, gouty arthritis

          -  History of lower limbs fracture

          -  History of operation for lower limbs

          -  Any infectious disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction