araag2/NLI4PR huggingface dataset:
Clinical trial: Efficacy Study of Activated Prothrombin Complex for Prevention of Bleeds in Hemophilia A With Inhibitors (NCT00221195)

Eligibility criteria:
Inclusion Criteria:

          -  hemophilia A, any severity, with documented history of high-titer inhibitor (>5BU);
             current use of bypassing agents (PCCs, aPCCs or rFVIIa) for treatment of bleeds; >/= 6
             bleeds requiring bypassing therapy in the previous 6 months

        Exclusion Criteria:

          -  concomitant immune tolerance therapy; clinically symptomatic liver disease, platelet
             count less than 100,000
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 24 Months old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Neo-angiogenesis in Inguinal Henia Implant ProFlor (NCT04541316)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who underwent inguinal hernia repair with the 3D dynamic responsive device
             named ProFlor

          -  Patients undergoing recurrent inguinal hernia repair after primary repair with the 3D
             dynamic responsive device named ProFlor

          -  Patients undergoing surgical procedure in the groin area after inguinal hernia repair
             with the 3D dynamic responsive device named ProFlor

        Exclusion Criteria:

          -  immunosoppressive therapy, > ASA 4 classification
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effectiveness of Active Video Games in Children With Intellectual Disabilities (NCT04277130)

Eligibility criteria:
Inclusion Criteria:

          -  students with ID (mild category) aged 8-18 years old from special education schools
             including primary and secondary schools;

        Exclusion Criteria:

          -  students without physical disability.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Ganaxolone Treatment in Children With Fragile X Syndrome (NCT01725152)

Eligibility criteria:
Inclusion Criteria:

          -  molecular documentation of FMR1 full mutation

          -  ages 6-17 yrs, inclusive

          -  sexually active subjects are required to use a medically acceptable form of birth
             control

        Exclusion Criteria:

          -  non-English or Spanish speaking subjects

          -  concomitant systemic steroid, vigabatrin, felbamate and ketoconazole

          -  changes in medications within last 2 months

          -  clinically unstable medical disease, progressive CNS disease/disorder

          -  history of recurrent status epilepticus

          -  unwilling to withhold grapefruit or grapefruit juice for the duration of the study

          -  actively suicidal
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Study to Evaluate the Efficacy of the Synera Patch Compared to Naproxen Sodium for Epicondylitis of the Elbow (NCT01525043)

Eligibility criteria:
Inclusion Criteria:

          -  Individuals with clinical evidence of lateral or medial epicondylitis of the elbow.

          -  Age 18 or higher

          -  Minimum of 4 on Question 5 of BPI

        Exclusion Criteria:

          -  Peripheral neuropathy of any origin in the index limb

          -  Cubital tunnel syndrome in patients with medial epicondylitis

          -  Cortisone injection in the last 4 weeks into the index limb

          -  Surgical intervention in the past for the epicondiitis

          -  Participants in any other clinical trial in the last 30 days

          -  Known allergy to lidocaine, tetracaine, NSAIDs or PABA

          -  Uncontrolled pain in the upper extremity or neck that may interfere with evaluation of
             study drug's response as deemed by the investigator

          -  Patient who is deemed to be medically unstable by the principal investigator including
             but not limited to Liver disease or Cardiac arrhythmias

          -  Patients who are pregnant, lactating or breast feeding

          -  Vaccination within the last weeks or planning on any vaccinations during the study or
             for 4 weeks after the study completion.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Electromoxibustion and Knee Health Education for Knee Osteoarthritis in Older Adults (NCT04034394)

Eligibility criteria:
Inclusion Criteria:

          1. ethnic Chinese;

          2. aged 60 years or above;

          3. ability to comprehend Chinese;

          4. fulfilling any 3 of the following criteria: i. morning stiffness </= 30 min; ii.
             crepitus on active joint motion; iii. bone tenderness; iv. bone enlargement; or v. no
             palpable joint warmth (This classification yielded 84% sensitivity and 89% specificity
             for OA knee diagnosis (Altman et al., 1986);

          5. having knee pain for at least 3 months;

          6. Knee pain ≥4 on a Likert pain scale from 1-10; and

          7. willing to provide informed consent.

        Exclusion Criteria:

          1. medical diagnoses or conditions that preclude individuals from active participation
             (e.g. dementia, post-stroke syndrome, alcohol or drug abuse);

          2. knee pain related to other conditions (cancer, fracture, rheumatoid arthritis,
             rheumatism) as screened according to the red flags for further investigation or
             referral in the National Clinical Guideline Centre 2014 Guidelines for Osteoarthritis
             of the knee (National Clinical Guideline Centre, 2014);

          3. presence of skin lesions or infections at the treatment sites;

          4. ever had knee replacement surgery or knee joint implant; and

          5. ever received moxibustion, electromoxibustion or steroid injection for knee pain over
             the past 6 months; Further investigation or referral, either at the screening or
             during the study, will be made when necessary.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Factors Influencing Fertility or Pregnancy Health (NCT04595760)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  healthy white women aged 21-42 who were planning to become

        pregnant

        -women enrolled in the 1982-1986 North Carolina Early Pregnancy

        Study (EPS) at the time they discontinued all methods of birth control
Female
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 42 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Females With Severe or Moderate Hemophilia A or B: an International Multi-center Study (NCT00936312)

Eligibility criteria:
Inclusion Criteria:

          -  Females with severe (FVIII<0.01u/ml) or moderate (FVIII 0.01≤0.05 u/ml) hemophilia A

          -  Females with severe (FIX<0.01u/ml) or moderate (FIX 0.01≤0.05u/ml) hemophilia B

          -  Willingness to participate in the study.

        Exclusion Criteria:

          -  Subjects who do not meet the inclusion criteria with respect to gender or hemophilia
             severity.
Female
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effect of Swimming on Premenstrual Syndrome (NCT03264612)

Eligibility criteria:
Inclusion Criteria:

          1. virgins.

          2. Their age ranged from 18 to 25 years old

          3. Their body mass index (BMI) ranged from 18 to 25 kg/m2.

          4. They were clinically and medically stable during the study

          5. Have regular menstrual cycle of 23 to 35 days duration

        Exclusion Criteria:

          1. cardiopulmonary or orthopaedic problems

          2. women taking any hormonal drugs or drugs that affect hormones as antidepressnats
             during the preceding 3 months before participation in the study

          3. any abnormality in ovulation or those with pelvic inflammatory diseases (PID).

          4. Women with endocrine abnormality as thyroid, pituitary or ovarian disorders
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 25 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Haemophilia Patients With Inhibitors Being Treated for Acute Joint Bleeds (NCT00486278)

Eligibility criteria:
Inclusion Criteria:

          -  12 years of age or older (at least 18 years in Croatia, France and United Kingdom
             (UK))

          -  Clinical diagnosis of congenital haemophilia A or B with a current positive inhibitor
             titre and a known peak inhibitor of above 5 Bethesda units (BU) (present or in the
             past) to human FVIII or IX and known antihuman FVIII or IX anamnestic response

          -  Minimum of 2 joint bleeds (haemarthroses of ankles, knees, or elbows) requiring
             haemostatic drug treatment within the previous 6 months, or at least 4 joint bleeds
             (hemarthroses of ankles, knees, or elbows) requiring haemostatic drug treatment within
             the previous 12 months at trial entry

        Exclusion Criteria:

          -  Known allergy to rFVIIa, and/or suspected allergy to trial product

          -  Platelet count lower than 50,000 mm^3 based on medical records at trial entry (visit
             1)

          -  Any clinical signs or history of thromboembolic events

          -  Advanced atherosclerotic disease

          -  Severe liver disease based on medical records within the past 12 months at trial entry
             (Visit 1), as defined by alanine aminotransferase (ALAT) above 3 times the upper limit
             of normal reference range

          -  Known active pseudo tumours (documented bleeding requiring treatment within the last 3
             months

          -  Subject had any (major) surgical procedure in the 30 days prior to screening into the
             trial. a. Catheter, ports and dental extractions do not count as surgeries and will
             not exclude the subject
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction