araag2/NLI4PR huggingface dataset:
Clinical trial: Antecedents of Bronchopulmonary Dysplasia (NCT00005293)

Eligibility criteria:
No eligibility criteria
Male
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis (NCT00552487)

Eligibility criteria:
Inclusion Criteria:

          -  Hashimoto thyroiditis euthyreot thyroid function with levothyroxin therapy written
             informed consent

        Exclusion Criteria:

          -  • hypothyroidism of other origin

               -  pregnancy and lactation

               -  oral contraception

               -  glucocorticoid therapy during the last 2 months

               -  History of malignancy or chronic infections (Hepatitis, HIV)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of Respecting the Circle of Life on Pregnancy Prevention Outcomes Among American Indian Adolescents (NCT02904629)

Eligibility criteria:
Inclusion Criteria:

          -  American Indian ethnicity

          -  Membership in the White Mountain Apache community. (Although the investigators
             anticipate the vast majority of participants will be White Mountain Apache tribal
             members, study participation is open to all American Indian individuals who live on
             the Fort Apache Indian Reservation or on/near the border).

          -  Participants ages 11+ must have parent/legal guardian consent

          -  Adult participants must sign written informed consent

        Exclusion Criteria:

          -  Inability to participate in full intervention or evaluation (e.g., planned move,
             residential treatment, etc.)

          -  Unwilling to be randomized
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 11 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Biochemical Versus Ultrasound Findings as Predictors of Fetal Loss in Cases of First Trimester Threatened Miscarriage (NCT03797508)

Eligibility criteria:
Inclusion Criteria:

          -  Singleton Pregnancy.

          -  Age20-35years.

          -  Gestational age between6 to 8weeks.

          -  Threatened miscarriage is diagnosed by vaginal bleeding, closed cervix and positive
             fetal life.

          -  Patients who are sure of their dates (three regular menstrual cycles before conception
             without the use of hormonal contraception.

        Exclusion Criteria:

        Patients with recurrent miscarriage or pregnancy of unknown location (PUL).

          -  Patients had ovulation induction medications or on progesterone treatment.

          -  Patients with past medical history of diabetes mellitus or chronic hypertension.

          -  Patients who are unsure of the last menstrual period date or with irregular menstrual
             cycle.

          -  Pregnancy associated with presence of ovarian cyst.

          -  Molar pregnancy.

          -  Those who had a history of maternal disease which would cause an increase in
             CA-125level. These diseases include chronic pelvic infection, endometriosis, myoma
             uteri, endometrioma and lung, kidney and hepatic diseases.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Safety and Efficacy of AFQ056 in Adolescent Patients With Fragile X Syndrome (NCT01357239)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Fragile X Syndrome, who are at least moderately ill based on a Clinical
             Global Impression Severity score of at least 4 and have qualifying scores on the ABC-C
             and IQ test at Visit 1

        Exclusion Criteria:

          -  Advanced, severe or unstable disease that may interfere with the study outcome
             evaluations

          -  Cancer within the past 5 years, other than localized skin cancer

          -  Current treatment with more than two psychoactive medications, excluding
             anti-epileptics

          -  History of severe self-injurious behavior

          -  Weigh less than 32 kg

          -  Females who are sexually active

        Other protocol-defined inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Diagnostic Accuracy of FDG PET/CT of Cranial Arteries in GCA (NCT03409913)

Eligibility criteria:
Inclusion Criteria:

        Cases:

          -  1) age ≥50 years, 2) CRP>15mg/l or ESR>40mm/h, 3) either a) cranial symptoms, b)
             new-onset extremity claudication or c) weight loss >5 kilograms or fever>38oC for >3
             weeks and a clinical diagnosis of giant cell arteritis judged by expert
             rheumatologist.

        Controls:

          -  age-(+/-3 years) and sex-matched malignant melanoma (MM) patients

          -  follow-up metastatic-disease-free FDG PET/CT ≥6 months after MM resection

        Exclusion Criteria:

          -  Previous diagnosis of polymyalgia or giant cell arteritis

          -  immunosuppresive treatment within last month
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: The Cardiovascular Genetic and Therapeutic Implications of Muscular Dystrophy (NCT00518817)

Eligibility criteria:
Inclusion Criteria:

          -  All patients with the diagnosis of muscular dystrophy.

        Exclusion Criteria:

          -  Patients that do not carry the diagnosis of muscular dystrophy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Month old.
Subject must be at most 65 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Characteristics of Back Pain Attendances at ED (NCT03762174)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who have attended Darlington Memorial Hospital between 01-08-2016 and
             31-07-2017

          -  Aged 16 or over

        Exclusion Criteria:

          -  Below the age of 16
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.


Patient description (medical language): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient description (patient's own words): I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Does the patient match the trial criteria? Entailment
Clinical trial: A Comparison of Effectiveness of Oral Sucrolfate, Alginate and Hydrotalcide in Dispeptic Pain Treatment (NCT03635372)

Eligibility criteria:
Inclusion Criteria:

          -  Stomach pain, swelling or dispeptic complaints.

          -  Men and women between the ages of 18-60.

          -  Patients with VAS> 5.

        Exclusion Criteria:

          -  Pregnancy and lactation.

          -  Sucralfate, alginate, hydrotalcite allergy.

          -  Emergency service arrives with acute psychiatric symptoms.

          -  Gastrointestinal system bleedings.

          -  Chronic renal failure, liver cirrhosis, structural and functional heart disease.

          -  Gastric malignancy and terminal illness.

          -  Patients suspected of having a different problem such as ileus, biliary colic,

          -  pancreatitis, hepatitis.

          -  Patients who refuse to participate in the study.

          -  Those who can not use VAS.

          -  Presence of ischemic findings on the arrival ECG.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Extended Half Life Factor (EHF) Products For Heavy Menstrual Bleeding in Hemophilia Carriers (NCT03272568)

Eligibility criteria:
Inclusion Criteria:

          -  Females of reproductive age who experience monthly menstrual bleedings

          -  Female Hemophilia A or B carrier (heterozygote, lyonized or Turner's Syndrome)

          -  FVIII or FIX activity ≤60% at time of the study

          -  Baseline Pictorial Bleeding Assessment Chart >150 mean at time of recruitment

          -  Negative pregnancy test at time of enrollment

          -  Both female and her male partner have agreed to use an acceptable barrier method of
             birth control (e.g., diaphragm, cervical cap, male condom, female condom, and
             spermicidal foam, sponges, and film) throughout the duration of this study (for
             sexually active participants)

        Exclusion Criteria:

          -  Has not reached menarche

          -  Menopause: natural or induced by surgical/medical treatment

          -  Pregnant or breasfeeding

          -  Female or her male partner refuses to use barrier method of birth control (for
             sexually active)

          -  Current use of any of the following contraceptives (copper IUD, oral combined,
             Progestin-only including but not limited to: Provera, Aygestin, Nexplanon, Implanon,
             Depo Provera, Mirena IUD)

          -  VWF:Ag or VWF:RCo <40%

          -  Diagnosis of a qualitative platelet disorder

          -  Personal history of thrombosis or superficial thrombosis

          -  First degree relative with a history of thrombosis

          -  Personal history of concomitant bleeding or clotting disorder

          -  Cigarette smoker

          -  Willing to avoid taking an anti-fibrinolytic agent (amicar, transexamic acid, lysteda)
             during the trial
Female
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction