Clinical trial: COVID-19 Antibody Plasma Research Study in Hospitalized Patients (NCT04524507)

Eligibility criteria:
Inclusion Criteria:

          1. Age at least 18 years

          2. Ability and willingness of participant or Legally Authorized Representative (LAR) to
             give written informed consent.

          3. Laboratory confirmed diagnosis of infection with SARS-CoV-2 by PCR

          4. Hospitalized for COVID-19 with one or more respiratory or gastrointestinal (GI)
             symptoms:

               -  COVID-19 associated respiratory symptoms include but are not limited to: cough,
                  shortness of breath, difficulty breathing, or sore throat

               -  COVID-19 associated GI symptoms include but are not limited to: loss of taste,
                  loss of sense of smell, diarrhea, nausea, or vomiting,

        Note: Respiratory and GI symptoms other than those listed above, must be noted as
        acceptable and signed by study PI or designee.

        Exclusion Criteria:

          1. Receipt of pooled immunoglobulin in past 30 days

          2. Current or prior enrollment in a SARS-CoV-2 antibody or T-cell therapeutic study.

             Note: Patients enrolled on other randomized controlled trials of pharmaceutical and/or
             non-pharmaceutical interventions for COVID and meeting eligibility criteria will not
             be excluded, as determined by study PI (or designee) on a case-by-case basis and as
             allowed by eligibility criteria of the other trials.

          3. Contraindication to transfusion or history of prior reactions to transfusion blood
             products. This may include religious or cultural objections to receiving blood
             products and transfusions.

          4. ABO-compatible titered plasma is not available

          5. > 10 days from noted COVID-related subjective or objective fever at randomization.
             Patients without subjective or objective fever, > 10 days from symptom onset as
             determined by study PI.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction