araag2/NLI4PR huggingface dataset:
Clinical trial: Gastric Reflux and Sinonasal Symptoms (NCT04105894)

Eligibility criteria:
Inclusion Criteria:

          -  Patient aged from18-50 years who have been diagnosed to have gastric reflux by
             gastroenterology departement before the start of treatment, and they also have
             sinonasal symptoms.

        Exclusion Criteria:

          -  Pregnant

          -  Significant nasal cavity malformations

          -  Oncological pathology

          -  Other sinonasal diseases
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis (NCT03087851)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women (postmenopausal for at least two years)

          -  Men above 50 years

          -  Treatment for at least two years with denosumab

          -  Last denosumab injection less than five months ago

        Exclusion Criteria:

          -  Low-energy vertebral fracture at any time

          -  Low-energy hip fracture within the last 12 months

          -  BMD T-score < -2,5 (lumbar spine, total hip or femoral neck)

          -  Alendronate treatment for more than three years prior to denosumab treatment

          -  Ongoing treatment with glucocorticoids

          -  Metabolic bone disease

          -  Hormone replacement therapy

          -  Cancer

          -  Estimated glomerular filtration rate (eGFR) < 35 mL/min

          -  Allergy to zoledronic acid

          -  Hypocalcaemia

          -  Contraindications for zoledronic acid according to the SPC
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Hydroxychloroquine in Giant Cell Arteritis (NCT00430807)

Eligibility criteria:
Inclusion Criteria:

          -  giant celle arteritis with at least 3 ACR criteria including a disgnostic temporal
             artery biopsy

          -  corticosteroid treatment since less than 1 month

          -  age less than 85 years

          -  signed informed consent

        Exclusion Criteria:

          -  amaurosis fugax, loss of vision, acute lumb ischemia, angina pectoris or myocardium
             infarctus, mesenteric ischemia or other vascular complications related to GCA

          -  low life expectancy (<2 years)

          -  corticosteroid treatment since more than 30 days whatever the dosage

          -  primary corticosteroid resistance defined by persistant symptoms despite prednisone
             for more than 15 days

          -  previous psychiatric troubles induced corticosteroids

          -  hydroxychloroquine contra-indicated
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: Early Pregnancy Evaluation by Three-Dimensional Ultrasound (NCT00342290)

Eligibility criteria:
-  INCLUSION CRITERIA:

        All pregnant subjects will be recruited under informed consent at Hutzel Hospital. The
        study population for both arms of this protocol will involve pregnant women between the
        ages of 15 years-old and older at Hutzel Hospital. The ethnic backgrounds are estimated to
        involve approximately 60 percent Caucasian and 40 percent African American between both
        sides.

          -  Accurate pregnancy dating criteria.

          -  Estimated gestational age less than or equal to 20 weeks' gestation.

          -  Visible fetus with normal heart rate and rhythm.

        EXCLUSION CRITERIA:

          -  Poor visualization of the fetus due to technical factors (e.g. obesity).

          -  Risk factors that increase risk for not keeping serial ultrasound appointments.

          -  Desire not to have vaginal ultrasound scans.
Female
Accepts Healthy Volunteers
Subject must be at least 15 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Clinical Trial to Evaluate the Safety and Efficacy of JP-1366 in Patients With Erosive Gastroesophageal Reflux Disease (NCT04282954)

Eligibility criteria:
Inclusion Criteria:

          -  Adults between 19 and 75 years old based on the date of written agreement

          -  Those who have been diagnosed with erosive gastroesophageal reflux disease(EGRD) of LA
             Grade A-D on the upper gastrointestinal endoscopy

          -  Those who experienced symptoms of heartburn or acid reflux within the last 7 days

        Exclusion Criteria:

          -  Those who have undergone gastric acid suppression or gastric, esophageal surgery

          -  Those who with clinically significant liver, kidney, nervous system, respiratory,
             endocrine, hematologic, cardiovascular, urinary system disease

          -  Clinically significant abnormal laboratory values during screening
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study of the Safety of Rabeprazole Administered to Adults With Gastroesophageal Reflux Disease (GERD) (NCT00216489)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with symptoms of erosive or ulcerative gastroesophageal reflux disease (GERD)
             during at least a period of 3 months prior to study initiation and symptoms of GERD
             for at least 3 days per week within the 2 weeks prior to study initiation. The
             symptoms of erosive or ulcerative gastroesophageal reflux disease includes the
             following: heartburn, aching behind the breastbone, a need for antacids, and
             difficulty in swallowing. Patients with evidence by endoscopy of erosive or ulcerative
             gastroesophageal reflux disease with no Barret-type tissue transformation.

        Exclusion Criteria:

          -  No narrowing or inflammation of the esophagus

          -  no known gastro-duodenal ulcer

          -  no infections (other than H. Pylori), inflammations or hemorrhage of the stomach,
             small or large intestine

          -  no prior surgery of the stomach or intestine

          -  no known history of primary kinetic disorders of the esophagus, other than GERD

          -  no history of enlarged veins of the esophagus or stomach

          -  no pregnant or nursing females, or those lacking adequate contraception.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Syncope Trial to Understand Tilt Testing Early or Recorders Study (NCT03974412)

Eligibility criteria:
Inclusion Criteria:

          -  50 years old

          -  syncope (defined in 2017 ACC/AHA/HRS guidelines[16]) in the prior 12 months

          -  diagnosis unclear after history, physical exam andelectrocardiogram

          -  no apparent risk of death due to the cause of syncope.

        Exclusion Criteria:

          -  inability to give informed consent

          -  unable to attend routine follow up in device clinic

          -  positive carotid sinus massage.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Contradiction
Clinical trial: Free Soft Tissue Graft in Treatment of Oral Lichen Planus (NCT00737854)

Eligibility criteria:
Inclusion Criteria:

          -  Biopsy confirmed symptomatic oral lichen planus: WHO histological criteria in
             combination with clinical appearance will be used for diagnosis

          -  Previous routine treatment modalities has been attempted including steroids and
             immunomodulatory or antioxidant agents. i.e patients who had resistant lesions to
             routine treatment .removal of possible triggering drugs was also considered.

          -  Patients of both sexes between 40 to 70 year's old

          -  Patients who have symptoms such as burning sensation, pain

          -  Patients who have localized precancerous lesions such as atrophic-erosive/plaque like
             lichen planus with diameter lesser than 2 cm

          -  Patients who agree to this treatment

          -  Patients who are willing for evaluation in first week after surgery and every two
             month for 1 years

          -  Patients who agree to final punch biopsy for histopathologic evaluation

        Exclusion criteria:

          -  Patients who unable to undergo oral surgery

          -  Patients suffering from any localized or systemic disease

          -  Pregnant patients

          -  Smokers

          -  Patients who can not continue the study for private or social reasons

          -  Patients with generalized oral lichen planus
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effects of Tegaserod on Mechanical Sensitivity of the Esophagus and Stomach in Patients With Heartburn and Dyspepsia. (NCT00171457)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female subjects at least 18 years of age.

          -  Subjects willing to undergo multiple nasogastric intubations.

          -  Patients with functional heartburn will need to meet ROME II criteria.

          -  Patients with symptoms consistent with dyspepsia (epigastric pain/discomfort
             characterized by bloating, postprandial fullness and early satiety)

        Exclusion Criteria:

          -  Subjects with clinically significant diarrhea or a diagnosis of diarrhea-predominant
             IBS.

          -  Subjects with a diagnosis of IBD, Barrett's esophagus, esophageal stricture or ring,
             or previous or current history of ulcer disease.

          -  Subjects with Diffuse Esophageal Spasm or Achalasia.

        Other protocol-defined inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment