araag2/NLI4PR huggingface dataset:
Clinical trial: Effect of Placing the Implant Crown on the Implant on the Same Day as the Implant vs. 4 Weeks Later. (NCT04319042)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 20 years

          -  Willingness to sign informed consent and to participate in the study

          -  Plaque index according to Silness and Loe of < 35% [26]

          -  Presence of a mandibular first molar that has to be extracted

          -  Sufficient vertical interocclusal space for the placement of an implant crown (7 mm)

          -  Presence of an opposing natural or artificial tooth

          -  Ridge height sufficient for the placement of a ≥ 10 mm-long implant

          -  Sufficient ridge width for the placement of a 4.1mm diameter implant

        Exclusion Criteria:

          -  Any physical or mental disorder that would interfere with the ability to perform
             adequate oral hygiene or the capability of providing written informed consent and
             compliance to the protocol

          -  Any disorder that would interfere with wound healing or represent a contraindication
             for implant surgery such as, but not limited to, uncontrolled diabetes or conditions
             resulting in or requiring immunosuppression, radiation, chemotherapy, frequent use of
             antibiotics or antiresorptive medication such as bisphosphonates

          -  Pregnancy or lactation

          -  Intention to become pregnant between inclusion and implant loading

          -  Heavy smoking habit with ≥ 10 cig/d

          -  Severe bruxism or clenching habits, present oro-facial pain

          -  Insufficient ridge width/height for the study implant

          -  Defect of any alveolar wall (secondary exclusion criterion at tooth extraction)

          -  ISQ < 70 (secondary exclusion criterion for Group A at implant placement, for Group B
             at loading visit)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Characterization of Influenza-like Illness in Mexico (NCT01418287)

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent by participant, or for pediatric participants, signed informed
             consent by parent/legal guardian and, where appropriate, signed assent by participant

          -  At least one respiratory symptom (e.g., shortness of breath, postnasal drip, cough)
             and

          -  One of the following criteria:

          -  Fever (≥ 38 °C by any method: oral, axillary, etc.) on examination or
             participant-reported fever (≥ 38° C) or feverishness in the past 24 hours

          -  One or more non-respiratory symptoms (e.g., malaise, headache, myalgia,chest pain)

          -  Consenting to provide aspirate or naso-pharyngeal swab

        Exclusion Criteria

          -  The onset of illness is more than 48 hours after hospitalization.

          -  Participants previously included in this study within the last 30 days.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Compare the Effects of Telemedicine Approach With Usual Care in Hypertension Management in China (NCT02919033)

Eligibility criteria:
Inclusion Criteria:

          1. age 21 years or older

          2. a clinical diagnosis of hypertension with uncontrolled BP in the previous three
             months, currently taking or about to take anti-hypertensive medications

          3. received high school or above level of education

          4. active user of smart phone (Android or Apple) and mobile Apps

          5. the average of three BP measurements during the screening visit at the CHC is ≥ 140/90
             mm Hg, or ≥ 130/80 mm Hg if the patient has diabetes or renal diseases;

          6. being able to give informed consent.

        Exclusion Criteria:

          -  acute coronary syndrome

          -  heart failure

          -  cardiac arrhythmia

          -  stroke within the past three months

          -  renal failure

          -  cancer

          -  dementia, severe or acute psychiatric illness, pregnancy or intention to be pregnant
             in the next 18 months, and hospitalization within 3 months.

          -  additional exclusion criteria include participation in another clinical trial, arm

          -  circumference >32 centimeters that may affect the accuracy of BP measurement due to
             cuff size limit of the tele-monitor's, and unwillingness to comply with the 12 month
             intervention duration.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: NOWDx Test for the Detection of Antibodies to COVID-19 in Lay Persons (NCT04799392)

Eligibility criteria:
Inclusion Criteria:

        Innate Infection Cohort>

          -  PCR positives: persons who were symptomatic for COVID-19 and have tested positive for
             COVID-19 with an EUA or FDA cleared PCR test; 7+ days post positive PCR test

          -  PCR negatives: persons who have never had COVID-19 and who have tested negative for
             COVID-19 with an EUA or FDA cleared PCR test; within 0-6 days post negative PCR test

          -  persons 2+ years old

        Vaccination Cohort>

          -  persons 7- 60 days post second dose of EUA COVID-19 vaccine

          -  persons 18+ years old

        Exclusion criteria:

        Innate Infection Cohort>

          -  PCR positives: persons with a COVID-19 positive test result >45 days old

          -  PCR negatives: persons with any prior COVID-19 positive result

          -  persons who have received COVID-19 vaccine

          -  persons <2 years old

        Vaccination Cohort>

          -  persons symptomatic or previously infected with COVID-19 prior to vaccination

          -  persons <18 years old
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 2 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Rescue Immunotolerance Study in Induction of Immune Tolerance (ITI)-Experienced Patients (RES.I.S.T. Experienced) (NCT01051076)

Eligibility criteria:
Inclusion Criteria:

          1. severe hemophilia A (FVIII<1%) with high responding inhibitors (peak levels >5 BU)

          2. male, any age;

          3. any inhibitor level at study enrollment;

          4. ability and willingness to participate to the study;

          5. previous ITI course of at least 9 months with a VWF-free FVIII concentrate at any
             dosage, such as recombinant FVIII and/or monoclonally purified FVIII.

        Exclusion Criteria:

          1. concomitant systemic treatment with immunosuppressive drugs;

          2. concomitant experimental treatment;

          3. previous history of myocardial infarction and/or cerebral stroke
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Investigation of Parents' Anxiety Level and Health Related Quality of Life in Different Types of Physical Disabilities (NCT04035967)

Eligibility criteria:
Inclusion Criteria:

          -  Literate mothers with physical disabilities or healthy children between the ages of 4
             and 16, without any known functional and psychological problems

          -  Literate mothers aged 4-16 years with healthy children, without any known functional
             and psychological problems

          -  Signed informed consent form

        Exclusion Criteria:

          -  Mothers of 20 healthy children will be included. with the children who have multiple
             disabilities

          -  Mothers of 20 healthy children will be included. with the children who have severe /
             moderate mental impairment

          -  Mothers of 20 healthy children will be included. with the children who have Down's
             syndrome or autism
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 24 Years old.
Subject must be at most 70 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Transcriptomic Profile of Endometrium in Different Histological Dating of Hormone Replacement Cycle (NCT03222882)

Eligibility criteria:
Inclusion Criteria:

          -  The inclusion criteria for RIF group were: unexplained repeated implantation failure
             (RIF) is defined as the absence of a gestational sac on ultrasound at 5 or more weeks
             after embryo transfer (ET) after 3 embryo transfers with high quality embryos or after
             the transfer of ≥10 embryos in multiple transfers.

        The inclusion criteria for control group were: (1) age <35 years; (2) unregular menstrual
        cycles of >37 days; (3) baseline follicle- stimulating hormone (FSH) < 9.0 IU/L; (4)
        endometrial thickness ≥7.0 mm on the day of hCG administration.

        Exclusion Criteria:

          -  The exclusion criteria were: (1) uterine abnormalities (double uterus, bicornuate
             uterus, unicornuate uterus); (2) intrauterine adhesions（moderate - severe）,
             endometriosis, adenomyosis, untreated hydrosalpinx, uterine fibroids (submucosal
             fibroids, nonmucosal fibroids >4.0 cm and/or endometrial pressure) (3) history of
             adverse pregnancy (including spontaneous abortion, stillbirth, and fetal
             malformation).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparison of Self-Fixating vs Non-Fixating Hernia Mesh (NCT02062775)

Eligibility criteria:
Inclusion Criteria:

          -  > 18 years

          -  ASA Classification I, II, III

          -  scheduled for elective TEP inguinal hernia repair

        Exclusion Criteria:

          -  ASA Classification IV or greater

          -  needing emergency surgery

          -  known history of narcotic dependence

          -  undergoing bilateral inguinal or combined umbilical hernia repair

          -  undergoing other procedures during same anesthetic

          -  undergoing recurrent inguinal hernia repair
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: A New Formulation of Intravenous Paracetamol for Fever Management (NCT02283203)

Eligibility criteria:
Inclusion Criteria:

          1. Written informed consent by the patient

          2. Patient of either gender

          3. Age equal to or greater than 18 years old

          4. Fever onset less than 24 hours

          5. Body temperature greater than or equal to 38.50C.

          6. Infection of the upper respiratory tract or of the lower respiratory tract or acute
             pyelonephritis or infection of the skin and soft tissues that can explain fever onset.

        Exclusion Criteria:

          1. Age below 18 years old

          2. Denial for written consent

          3. Intake of paracetamol for any reason either orally or intravenously or intramuscularly
             the last 12 hours

          4. Intake of any non-steroidal anti-inflammatory drug the last 8 hours

          5. Intake of any steroidal anti-inflammatory drug the last 12 hours

          6. History of liver cirrhosis

          7. Serum creatinine greater than 3 mg/dl

          8. Aspartate aminotransferase more than 3 times greater than the upper normal limit for
             the hospital lab

          9. Known allergy to non-steroidal anti-inflammatory drugs or to paracetamol

         10. Pregnancy or lactation

         11. Active bleeding of the upper or the lower gastrointestinal tract

         12. Thrombocytopenia defined as any absolute platelet count below 50000/mm3.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction