araag2/NLI4PR huggingface dataset:
Clinical trial: Double and Single Intrauterine Insemination In Controlled Ovarian Stimulation (COH) Cycles With Multifollicular Development (NCT00993902)

Eligibility criteria:
Inclusion Criteria:

          -  Unexplained and mild male factor infertile patients

          -  Minimum 2 follicles >16 mm at the day of HCG

          -  First 3 cycles

        Exclusion Criteria:

          -  Basal FSH >12 mIU/L

          -  Total antral follicle count<6

          -  Severe male factor infertility
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 37 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effect of Platelet Rich Plasma on Lateral Epicondylitis (NCT01851044)

Eligibility criteria:
Inclusion Criteria:

          -  The duration of symptoms over 3 months

          -  Primary conservative treatment (physiotherapy, NSAID, ...) has been tried

        Exclusion Criteria:

          -  Significant systemic diseases

          -  Any surgical operation of the particular elbow
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Role of Copper-Albumin Complex in Treatment of Knee Osteoarthritis in Human (NCT03736109)

Eligibility criteria:
Inclusion Criteria:

          -  Patients of both sexes and over 40 years of age diagnosed with unilateral or bilateral
             symptomatic OA of the knee who met the criteria of the American College of
             Rheumatology (ACR).

          -  Patients who were rated grade II or III on the Kellgren and Lawrence (K&L)
             radiological scale [19].

          -  Patients with symptomatic OA with a global mean pain in the knee >40 mm on a Visual
             Analogue Scale (VAS) for pain assessment.

        Exclusion Criteria:

          -  Women who were pregnant or breastfeeding

          -  Patients who were grade I or IV on K&L radiological scale.

          -  Patients who have had a prosthesis replaced in the 12 months prior to inclusion.

          -  Obesity
No condition on gender to be admitted to the trial.

Subject must be at least 40 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: AAI in Elderly Patient With Chronic Pain (NCT04079985)

Eligibility criteria:
Inclusion Criteria:

          -  ≥65 years

          -  diagnosis of chronic benign joint pain

          -  polypharmacy (>5 drugs or active ingredients, of which 2 or more had been prescribed
             for pain)

        Exclusion Criteria:

          -  severe cognitive deterioration (GDS> 5)

          -  allergy to or fear of animals
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction
Clinical trial: Role of Copper-Albumin Complex in Treatment of Knee Osteoarthritis in Human (NCT03736109)

Eligibility criteria:
Inclusion Criteria:

          -  Patients of both sexes and over 40 years of age diagnosed with unilateral or bilateral
             symptomatic OA of the knee who met the criteria of the American College of
             Rheumatology (ACR).

          -  Patients who were rated grade II or III on the Kellgren and Lawrence (K&L)
             radiological scale [19].

          -  Patients with symptomatic OA with a global mean pain in the knee >40 mm on a Visual
             Analogue Scale (VAS) for pain assessment.

        Exclusion Criteria:

          -  Women who were pregnant or breastfeeding

          -  Patients who were grade I or IV on K&L radiological scale.

          -  Patients who have had a prosthesis replaced in the 12 months prior to inclusion.

          -  Obesity
No condition on gender to be admitted to the trial.

Subject must be at least 40 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Study to Assess Safety and Efficacy of Filgotinib, Lanraplenib and Tirabrutinib in Adults With Active Sjogren's Syndrome (NCT03100942)

Eligibility criteria:
Key Inclusion Criteria:

          -  Diagnosed with primary or secondary SjS according to the 2002 American European
             Consensus Group (AECG) classification

          -  Active SjS as defined by an European League Against Rheumatism (EULAR) Sjogren's
             syndrome disease activity index (ESSDAI) ≥ 5

          -  Seropositivity for antibodies to SjS-associated antigens A and/or B (anti-SSA or
             anti-SSB)

        Key Exclusion Criteria:

          -  Concurrent treatment with any biologic disease modifying antirheumatic drug (bDMARD)
             (prior bDMARD treatment allowed with appropriate washout as per study protocol)

        Note: Other protocol defined Inclusion/Exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Randomized Controlled Trial to Prevent Peritoneal Seeding in Gastric Cancer (NCT01683864)

Eligibility criteria:
Inclusion Criteria:

          1. Histologically proven gastric adenocarcinoma: uT1,uT2, uT3, Nx, M0

          2. No prior chemotherapy

          3. Patients of full age, independent of gender ECOG ≤ 2

          4. No dissemination of the tumor confirmed by CT of the lung and the abdomen.

          5. Signed Consent form of the Patient agreeing to investigations

          6. Leucocytes > 3.000/µl

          7. Thrombocytes > 100.000/µl

          8. Creatinine ≤ 1.5mg/dl and or Clearance > 60 ml/min

          9. informed consent of the patient

         10. normal ejection-fraction of the heart

        Exclusion Criteria:

          1. Dissemination of the tumor or non-resectable primary tumor

          2. Malignant secondary disease < 5 years in the past (Exception: in-situ-carcinoma of the
             cervix and appropriately treated basal cell carcinoma of the skin)

          3. Patient not of full age

          4. Inflammatory chronic bowel disease

          5. Inclusion of the patient in a different study

          6. Pregnancy or lactation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: The Effects of Over-the-Counter Products on the Skin (NCT03641430)

Eligibility criteria:
Inclusion Criteria:

          -  Participants must be over the age of 18 years old with healthy skin;

          -  Participant must be willing and comply with the requirements of the protocol;

          -  Participant must have the ability to understand and communicate with the investigator;

          -  Participant must provide informed consent.

        Exclusion Criteria:

          -  Subjects who are unable to provide informed consent;

          -  Subject with significant medical history or current skin diseases that the
             investigator feels is not safe for study participation;

          -  Subjects who self-report that they are pregnant or nursing;

          -  Subjects who do not speak English or have difficulty hearing or are otherwise impaired
             for providing informed consent and communicating with the investigator;

          -  Subjects with known bleeding disorders or diathesis;

          -  Subjects with a history of keloids or excessive scarring;

          -  Subjects with known allergy to lidocaine, epinephrine, or any of the tested products;

          -  Subjects who foresee intensive UV exposure during the study (e.g. sunbathing, tanning
             beds).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Postural Sway at Menstrual Cyclus (NCT03586804)

Eligibility criteria:
Inclusion Criteria:

          -  Have dysmenorrheal syndrome

          -  Have menstrual cycle without pain

        Exclusion Criteria:

          -  Have another health problem (systemic, neurologic, orthopedic or psychiatric)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 30 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Neuraxial Pethidine After Lumbar Surgery Trial (NCT00163553)

Eligibility criteria:
Inclusion Criteria:

          -  Adults undergoing lumbar spinal surgery

        Exclusion Criteria:

          -  Lack of informed patient consent

          -  Acute or chronic renal failure

          -  Known allergy or intolerance to pethidine or tramadol

          -  Chronic respiratory insufficiency

          -  Epidural contraindicated (coagulopathy, systemic infection)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient description (patient's own words): I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Does the patient match the trial criteria? Entailment