araag2/NLI4PR huggingface dataset:
Clinical trial: Comparative Study Between ICSI Results in Transvaginal Ultrasound Guided Embryo Transfer and Transabdominal Ultrasound Guided Embryo Transfer (NCT03683043)

Eligibility criteria:
Inclusion Criteria:

          -  Infertile female patients aged 20-37 years old undergoing IVF

          -  Long protocol

          -  Embryo transfer of fresh cycles D3

        Exclusion Criteria:

          -  Uterine abnormalities e.g. sub-mucous fibroid, or fibroids indenting the endometrium,
             polyps, Ashermann, etc.

          -  Poor responders

          -  Female patients ˃35 years old

          -  Medical disorders e.g. DM, HTN

          -  Immunological disorders e.g. SLE, APS

          -  Cervical distortions

          -  Thyroid or adrenal dysfunction

          -  Endometriosis grade 3 or 4
Female
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 37 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Plasma Total Antioxidant Status and Thiobarbituric Acid-reacting Substances in Patients With Inguinal Hernia (NCT02336256)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with inguinal hernia.

        Exclusion Criteria:

          -  Patients with acute disease and severe chronic disorder.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Study of the Molecular Basis in the Pathophysiology of Food Intake and Growth in Children (NCT00830141)

Eligibility criteria:
Inclusion Criteria:

          -  Group1: Children with GH deficiency diagnosed by 2 provocative tests with peak GH less
             than 10 ng/ml.

          -  Group 2:Children with height less than the 3rd centile without any etiology

          -  Group 3:children with failure to thrive until the age of 3 years.

          -  Group 4: children with obesity defined by BMI above the 90th centile for age and sex.

          -  Group 5: children with no endocrine diseases and without obesity or short stature.

        Exclusion Criteria:

          -  Children with known pediatric or endocrine diseases.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Norwegian Adenomyosis Study I (NCT02201719)

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal women aged 30 - 50 years old

          -  scheduled for vaginal, abdominal or laparoscopic total hysterectomy

          -  one or more of the following clinical symptoms: bleeding disorders (menorrhagia,
             irregular bleeding, hypermenorrhoea), chronic pelvic pain, dysmenorrhoea, or
             dyspareunia

          -  junction zone definable

        Exclusion Criteria:

          -  postmenopausal women,

          -  pregnancy

          -  gynecological cancer

          -  GnRH analog therapy or systemic hormone therapy in the last three months prior to
             hysterectomy

          -  junctional zone not identifiable
Female
Accepts Healthy Volunteers
Subject must be at least 25 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Sonography and Haemophilia (NCT04550988)

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients (≥ 18 years of age) suffering from severe haemophilia A or B

          -  No professional medical background

          -  Submitted written consent to participate in the study and to use their study related
             pseudonymized data

        Exclusion Criteria:

          -  Patients suffering from other bleeding diseases

          -  Participants < 18 years of age

          -  Participants without written consent

          -  Professional medical background
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy of Pancrelipase on Postprandial Belching and Bloating. (NCT00266721)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects will have either bothersome upper abdominal discomfort, bloating (feeling of
             abdominal distention) or belching following meals for at least 12 month's duration.
             Subjects must have had a normal upper gastrointestinal endoscopy and/or upper GI
             series during the preceding three years.

        Exclusion Criteria:

          -  Individuals with a history suggestive of organic disease such as recent weight loss,
             nausea, vomiting, GERD, recent changes in bowel habits will be excluded from the
             study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Implications for Quality of Life and Quality of Care in Patients With Hereditary Haemochromatosis (NCT01991925)

Eligibility criteria:
Inclusion Criteria:

          -  phase 1: experts in the field of haemochromatosis (hepatologists, hematologists,
             endocrinologists, general practitioner, nurses, ...)

          -  phase 2: patients with hereditary haemochromatosis, treatment with phlebotomy since 3
             months, Dutch/English speaking

        Exclusion Criteria:

          -  patients with secundary iron overload

          -  phlebotomy treatment less than 3 months

          -  language: no Dutch or English
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: German Pediatric Hemophilia Research Database (NCT02912143)

Eligibility criteria:
Inclusion Criteria:

          -  hemophilia A or B

          -  FVIII/FIX <1% to 25%

          -  informed consent

        Exclusion Criteria:

          -  no consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: A Trial of EBUS-TBNA Versus Conventional TBNA in Diagnosis of Sarcoidosis (NCT01908868)

Eligibility criteria:
Inclusion Criteria:

        Consecutive patients presenting with clinicoradiological features suggestive of sarcoidosis
        and an indication for transbronchial needle aspiration

        Exclusion Criteria:

          -  Pregnancy

          -  Hypoxemia (SpO2 <90%) on room air

          -  Poor lung function (forced expiratory volume in first second [FEV1] <1L)

          -  Patients with deranged clotting profile (prothrombin time >3 seconds above control;
             activated partial thromboplastin time >10 seconds above control, platelet count
             <50000/µL)

          -  Patients already initiated on glucocorticoids

          -  Diagnosis of sarcoidosis possible on minimally invasive techniques such as skin biopsy
             or peripheral lymph node biopsy and failure to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Phase I/III Study of D961H 10 mg and 20 mg in Japanese Paediatric Patients With Gastrointestinal Acid Related Diseases (NCT02153398)

Eligibility criteria:
Inclusion Criteria:

          -  Provision of signed written informed consent from the patient's guardian

          -  Patients aged ≥ 1 year to 14 years old

          -  Patients who have a diagnosis of or suspected to have GU, DU, AU, NERD, RE or
             Zollinger-Ellison syndrome.

        Exclusion Criteria:

          -  Patients less than 10 kg in weight.

          -  Use of any other investigational compounds or participations in another clinical trial
             within 4 weeks prior to the randomisation/registration.

          -  Significant clinical illness within 4 weeks prior to the registration

          -  Presence of hepatic diseases or other conditions that could interfere with evaluation
             of the study as judged by the investigators.

          -  Positive for pregnancy test by urinary or lactation for post-menarchal females.

          -  Previous total gastrectomy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 14 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Oral Androgens in Man-4: (Short Title: Oral T-4) (NCT00399165)

Eligibility criteria:
Inclusion Criteria:

          -  Males between 18 to 55 years of age

          -  In good general health based on normal screening evaluation (consisting of a medical
             history, physical exam, normal serum chemistry, hematology, and baseline hormone
             levels)

          -  Subject must agree not to participate in another research drug study for the duration
             of the study

          -  Subject must agree to not donate blood during the study

          -  Subject must be willing to comply with the study protocol and procedures

        Exclusion Criteria:

          -  Men in poor general health, with abnormal blood results (clinical laboratory tests or
             hormone values)

          -  A known history of alcohol or drug abuse

          -  A history of testicular disease or severe testicular trauma,

          -  A history of bleeding disorders or current use of anti-coagulants

          -  A history of sleep apnea and/or major psychiatric disorders

          -  A body-mass index greater than 35,

          -  A history of or current use of testosterone

          -  Infertility
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment