araag2/NLI4PR huggingface dataset:
Clinical trial: Influence on Human Male Fertility of Testosterone After Intranasal (MPP10) or Transdermal (AndroGel™) Application (NCT00705796)

Eligibility criteria:
Inclusion Criteria:

          -  Age greater than or equal to 50 years but not older than 80 years of age;

          -  Serum testosterone level <13.8 nmol/l;

          -  Sperm concentration > 40 Million/ml;

          -  Willing to give written informed consent.

        Exclusion Criteria:

          -  Testicular diseases or having had any surgical procedures applied to the testes;

          -  History or currently existing serious disease of any type, in particular liver, kidney
             or heart disease, any form of diabetes mellitus, cancer or psychiatric illness;

          -  Current androgen, anabolic steroid or sex hormone treatment or any treatment with such
             compounds in the previous 6 months;

          -  Blood donation within the 12-week period before the initial study dose.

          -  History of, or current nasal disorders (e.g. seasonal or perennial allergic rhinitis,
             atrophic rhinitis, polyposis, abuse of nasal decongestants, clinically relevant nasal
             septum deviation, recurrent epistaxis) or sleep apnea;

          -  Elevated serum PSA levels (> 4 ng/ml for subjects >= 50 years of age);
Male
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Laparoscopic Versus Open Mesh Repair of Bilateral Primary Inguinal Hernia (NCT04437784)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with painless uncomplicated primary bilateral inguinal hernias

        Exclusion Criteria:

          -  Immune compromised patients

          -  Coagulopathy

          -  Chronic liver or renal disease

          -  High-risk patients unfit for major surgery (ASA III or IV),

          -  Massive scrotal hernias, Recurrent or Complicated hernias

          -  Groin pain due to any other pathology

          -  Previous infra-umbilical surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: HEPFER-Evaluation of a New Phenotypic Biological Marker in Genetic Type 1 Hemochromatosis (NCT01784939)

Eligibility criteria:
Inclusion Criteria:

          -  Men, at least 18 years old

          -  hereditary hemochromatosis C282Y homozygous diagnosed and followed in the service of
             Liver Diseases, University Hospital of Rennes

          -  Maintenance therapy with phlebotomy for at least 1 year with stable iron stock on the
             basis of at least four previous plasma ferritin < 50μg / L,

          -  Written, free and informed consent

        Exclusion Criteria:

          -  Intercurrent illness unrelated to hemochromatosis causing cytolysis or inflammatory
             reaction.

          -  Person with a measure of legal protection (guardianship)
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study to Compare the Effectiveness of Two Different Outpatient Endometrial Ablation Techniques Used for Heavy Periods (NCT01124357)

Eligibility criteria:
Inclusion Criteria:

          -  Women with no desire to preserve their fertility who have heavy menstrual bleeding
             without organic pathology (DUB) of more than six months duration

          -  Premenopausal follicular follicle stimulating hormone (FSH) level of less than 40
             IU/L.

          -  Associated functional disability (negative impact on life quality).

          -  Lack of response to medical treatment.

          -  Prepared to undergo surgical treatment without general anaesthesia

        Exclusion Criteria:

          -  Women under 25 years

          -  Suspected genital tract infection

          -  Uterine pathology including endometrial pathology on endometrial biopsy (e.g.
             endometrial hyperplasia or carcinoma) and structural lesions (e.g. uterine
             malformations, adhesions, polyps, submucous fibroids or extracavity fibroids > 3cm in
             diameter) as identified on pelvic ultrasound and/or outpatient hysteroscopy.

          -  Uterine cavity length >11cm

          -  Adnexal pathology

          -  Previous open myomectomy or endometrial ablation / resection and classical caesarian
             section

          -  patients considered vulnerable (e.g. current mental illness, emotionally labile,
             learning difficulties, immaturity)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.


Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effects of Lumbar Traction on the Straight Leg Raise Test and Pain (NCT04728685)

Eligibility criteria:
Inclusion Criteria:

          -  Back pain for less than 3 months

          -  Positive unilateral Straight Leg Raise test which includes reports of back and leg
             pain or paraesthesia below 45-degree hip flexion

          -  At least one additional neurological sign should be present including- (a) Diminished
             Achillis/Hamstring tendon reflex, tested in the supine position or (b) Hyposthesia in
             any of the L4-S2 dermatome, or (c) Muscle weakness in any of the L4-S2 myotome.

          -  MRI evidence of L-4-L5 or L5-S1 disc prolapse or both.

        Exclusion Criteria:

          -  Malignancy, Tuberculosis, Osteoporosis, Osteomyelitis of the vertebral column

          -  Cord compression, Pregnancy, Hypertension, Cardiovascular disease, Joint hyper
             mobility

          -  Subjects who could not tolerate the traction force secondary to being in an acute
             stage of back pain.

          -  Subjects who have taken previous physiotherapy treatment in the last three months for
             back pain.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient description (patient's own words): I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Does the patient match the trial criteria? Contradiction
Clinical trial: Apotransferrin in Atransferrinemia (NCT01797055)

Eligibility criteria:
Inclusion Criteria:

          -  Established diagnosis of atransferrinemia, defined as serum levels of transferrin
             below 40 mg/dl

          -  Informed consent

        Exclusion Criteria:

          -  Known with allergic reactions against human plasma or plasma products

          -  Having detectable anti-immunoglobulin A antibodies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: COVID-19 Hyperinflammation Syndrome (COV-HI): Protocol for a Rapidly Executed Cohort Study (NCT04385069)

Eligibility criteria:
Inclusion Criteria:

        - Adults (18 years and over) admitted to hospital who are COVID-19 positive (PCR positive
        on a swab, through routine clinical laboratory testing)

        Exclusion Criteria:

        - No exclusion criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: A Prospective Study Comparing Single and Multiport Laparoscopic Inguinal Hernia Repair (NCT01660048)

Eligibility criteria:
Inclusion Criteria:

          -  all referred patients with inguinal hernias

        Exclusion Criteria:

          -  workers Compensation cases

          -  previous extraperitoneal intervention

          -  unfit for a general anaesthetic

          -  strangulated hernias

          -  present of or previous ventral hernia repair extending 5 cm below umbilicus
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 86 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee (NCT00604539)

Eligibility criteria:
Inclusion Criteria:

          -  Primary OA of the knee according to ACR with synovitis criteria (warmth, swelling or
             effusion);

          -  OA of radiological stages 2 and 3 according to Kellgren-Lawrence;

          -  Minimum joint space width ≥2 mm in the medial femorotibial compartment on standing
             knee X-ray;

          -  VAS of pain while walking ≥40 mm.

        Exclusion Criteria:

          -  Known allergy to chondroitin sulphate;

          -  Progressive or serious pathologies (cancer, AIDS,...);

          -  Other bone and articular diseases (antecedents and/or current signs) such as
             chondrocalcinosis, Paget's disease, rheumatoid arthritis, aseptic osteonecrosis, gout,
             septic arthritis, ochronosis, acromegaly, hemochromatosis, Wilson's disease,
             osteochondromatosis;

          -  Corticosteroids (oral, injectable), indomethacin, therapeutic dose of glucosamine or
             chondroitin sulphate during the 12 weeks preceding inclusion;

          -  Hyaluronic Acid (intra-articular pathway) during the 26 weeks preceding inclusion;

          -  Radioactive synovectomy during the 12 weeks preceding inclusion;

          -  If the patient is receiving NSAID at baseline (D0), it should be maintained at a
             stable dosage as much as possible from D0 to D180. In the open phase of the study
             (D180 to D360), NSAID will also be allowed as rescue medication along with
             acetaminophen.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Vital Sign Comparison Between Lifelight and Standard of Care - Development (NCT04003662)

Eligibility criteria:
Inclusion Criteria:

          -  I1. Sufficiently conversant in the English language to satisfy I3.

          -  I2. Able and willing to comply with all study requirements.

          -  I3. Able and willing to provide written informed consent to participate (including by
             parent or legal guardian if under 16 years old).

        Exclusion Criteria:

          -  There are no exclusion criteria.
No condition on gender to be admitted to the trial.

Subject must be at least 3 Years old.


Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment