araag2/NLI4PR huggingface dataset:
Clinical trial: Efficacy of Three Weekly Injections of a Bacterial-- Sourced Hyaluronate on Pain and Function in Patients With Knee Osteoarthritis (OA) (NCT01185444)

Eligibility criteria:
Inclusion Criteria:

          -  (1) age 40 years or older, presence of a primary knee OA with knee pain for at least 6
             months despite conservative treatment (rest, physical therapy, orthoses or pain
             medications etc.); (2) had average pain on knee movement of at least 3 cm on a 10-cm
             VAS; (3) had a current Lequesne index score (described below) >7 (possible range,
             0-24); (4) were willing to discontinue all nonsteroidal anti-inflammatory drugs
             (NSAIDs) or other analgesic medication (except for rescue medication) for the duration
             of the study; and (5) were willing to not receive physical therapy or trial of shoe
             modifications or orthoses during the study period.

        Exclusion Criteria:Exclusion criteria included previous orthopedic surgery on the spine or
        lower limbs, knee instability or marked deformity on examination, clinically apparent tense
        effusion of the knee, intra-articular steroid or HA injection in any joint within the past
        6 months, and concomitant inflammatory arthropathy or other rheumatologic, neurological,
        cardiovascular or psychiatric disorders that would interfere with the clinical assessment
        during the study period.

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Single-dose Linaclotide for Capsule Endoscopy Preparation (NCT02465385)

Eligibility criteria:
Inclusion Criteria:

          -  Schedule for video endoscopy at UVHS

          -  Ability to speak, read and write English

          -  Age >18

          -  Able to provide consent

        Exclusion Criteria:

          -  Prisoner

          -  Woman who is currently pregnant or breastfeeding

          -  Allergy to linaclotide

          -  Patients with known or suspected mechanical gastrointestinal obstruction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Preoperative Buccal Misoprostol on Blood Loss in Second-trimester Dilation and Evacuation Abortion (NCT01436266)

Eligibility criteria:
Inclusion Criteria:

          -  English or Spanish speaking

          -  Gestational age between 16 weeks 6 days and 20 weeks 6 days gestation by ultrasound
             dating on the day of enrollment

          -  Ultrasound used for dating purposes must be within the last two weeks.

          -  Women 18-50 years of age undergoing surgical termination of pregnancy

        Exclusion Criteria:

          -  Spontaneous fetal demise

          -  Ruptured membranes or intrauterine infection

          -  Fibroids that significantly distort the uterine shape

          -  Uterine abnormality such as unicornuate uterus

          -  Prior transmural myomectomy

          -  Severe oligohydramnios

          -  Morbid obesity with BMI>45

          -  Inability to place osmotic dilators
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Individualized Dietetic Intervention-eating Habits in Obese Hispanic Children of Low Socioeconomic Status (NCT01925976)

Eligibility criteria:
Inclusion Criteria:

          -  Attendance from first to sixth grade

          -  Ages 6-12 years

          -  BMI ≥ 85th percentile for age and sex

          -  Hispanic origin

          -  Both parents Hispanic

          -  Low socioeconomic status

          -  Signed consent from both parents/care givers and active assent from children

        Exclusion Criteria:

          -  Disapproval by the children's physician due to any at-risk medical condition known by
             the parents
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: LNG-IUS for Treatment of Dysmenorrhea (NCT01601366)

Eligibility criteria:
Inclusion Criteria:

          1. Women have dysmenorrhoea and/or chronic pelvic pain secondary to adenomyosis.

          2. Planning for birth spacing for at least 2 years.

          3. Patient aged between 20-45 years old.

          4. Ultrasonographic and Doppler examination suggestive of adenomyosis.

          5. Living in a nearby area to make follow-up reasonably possible.

        Exclusion Criteria:

          1. Pregnancy

          2. Evidence of defective coagulation.

          3. History or evidence of malignancy.

          4. Hyperplasia in the endometrial biopsy.

          5. Incidental adnexal abnormality on ultrasound.

          6. Contraindications to COCs.

          7. Absolute contraindication of LNG-IUS insertion.

          8. Previous endometrial ablation or resection

          9. Uninvestigated postcoital bleeding

         10. Untreated abnormal cervical cytology
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effectiveness Of Expectant Management In The Tubal Ectopic Pregnancy (NCT01876004)

Eligibility criteria:
Inclusion Criteria:

          -  Hemodynamic stability

          -  Initial β-hCG <2000 mIU / mL

          -  Titers of β-hCG in decline in 48 hours before treatment

          -  Adnexal mass <5.0 cm

          -  Desire for future pregnancy

        Exclusion Criteria:

          -  Alive embryo

          -  Ectopic pregnancy other than in tubal location

          -  Pregnancy of unknown location
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Dose-Response, Safety and Efficacy of Febuxostat in Subjects With Gout (NCT00174967)

Eligibility criteria:
Inclusion Criteria:

          -  Hyperuricemia (serum uric acid ≥8.0 mg/dL).

          -  Must meet American College of Rheumatology criteria for gout.

          -  Must have adequate renal function (serum creatinine <1.5 mg/dL).

          -  Females of childbearing potential who are sexually active must agree to use adequate
             contraception, and can neither be pregnant nor lactating from Screening throughout the
             duration of the study.

        Exclusion Criteria:

          -  History of xanthinuria

          -  Alcohol consumption >14/week

          -  Has a history of significant concomitant illness.

          -  Has active liver disease.

          -  Has a body mass index greater than 50 kilogram per meter² (kg/m²)

          -  Any other significant medical condition that would interfere with the treatment,
             safety or compliance with the protocol, as defined by the investigator.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Essential Voice Tremor: A Study of Botulinum Toxin Treatment and Injection Augmentation (NCT02711995)

Eligibility criteria:
Inclusion Criteria:

          -  Male and female patients ages 18-100 who have been diagnosed with essential tremor of
             the voice (EVT) Diagnosis Code 478.75 Laryngeal Spasm.

        Exclusion Criteria:

          -  WCMC subjects under age 18

          -  Pregnant patients

          -  Patients with laryngeal pathology besides tremor, including but not limited to polyps
             and other benign lesions, precancerous or cancerous changes, vocal fold paralysis, or
             other laryngeal disorders of mobility
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Contradiction
Clinical trial: Efficacy and Safety of Growth Hormone Treatment in Juvenile Idiopathic Arthritis (NCT00420251)

Eligibility criteria:
Inclusion Criteria:

          -  Polyarticular or systemic juvenile idiopathic arthritis,

          -  Growth velocity below the 25th percentile and or short stature ,

          -  Treatment with glucocorticoids for at least the previous 6 months before inclusion,

          -  Prepubertal stage,

          -  Bone age below 10 in girls and 12 in boys,

          -  Growth hormone levels after stimulation with clonidine or arginine above 10 ng/ml

        Exclusion Criteria:

          -  Previous treatment with growth hormone,

          -  Endocrinopathy,

          -  Additional chronic disease beside juvenile idiopathic arthritis,

          -  Malignant disase,

          -  Chromosomal aberration or othe syndromal disease,

          -  Previous treatment with Oxandrolone,

          -  Small for gestational age,

          -  Elevated fasting glucose level
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 14 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Treatment of Vitamin D Insufficiency (NCT00933244)

Eligibility criteria:
Inclusion Criteria:

          -  Vitamin D insufficiency, defined as a serum 25(OH)D 16 to 25 ng/mL by high performance
             liquid chromotography assay

          -  Women ≥ 5 years past the date of last menses or bilateral oophorectomy, or ≥ 60 years
             old if they had prior hysterectomy without bilateral oophorectomy

          -  Total dietary and supplemental calcium intake < 600 mg daily but ≤ 1,400 mg daily,
             based on a food frequency questionnaire

        Exclusion Criteria:

          -  Women > 75 years old

          -  Hypercalcemia (serum calcium corrected for albumin > 10.4 mg/dL)

          -  Nephrolithiasis by medical record or patient report

          -  Inflammatory bowel disease, malabsorption or chronic diarrhea

          -  Stage 3, 4 or 5 Chronic Kidney Disease based on the Modification of Renal Diet (MDRD)
             formula

          -  Use of bone-active medications within the past 6 months including bisphosphonates,
             estrogen compounds, calcitonin, teriparatide, oral corticosteroids and anticonvulsants

          -  Allergy or intolerance to orange juice

          -  Allergy or intolerance to sunscreen

          -  Prior adult clinical fragility fracture of the hip, spine or wrist or a T-score below
             -2.5 at the lumbar spine or femur
Female
Accepts Healthy Volunteers

Subject must be at most 75 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment