araag2/NLI4PR huggingface dataset:
Clinical trial: Safety and Efficacy of Long-term Treatment With SCT800 in Previously Treated Hemophilia A Patients. (NCT03947567)

Eligibility criteria:
Inclusion Criteria:

          -  Male patients who are diagnosed with severe (laboratory tested FVIII:C <2%) hemophilia
             A;

          -  Patients Who Completed trial of SCT800-A302 or SCT800-A 303 and New PTP(previously
             treated patients)(Previously received FVIII prophylactic or bleeding treatment, have
             the relevant records and are verified to have accumulated exposures days( EDs) ≥150
             days;

          -  Negative FVIII inhibitor assay results (laboratory tested Nijmegen-Bethesda assay
             result <0.6 BU(Bethesda unit)/mL);

          -  The treatment records of at least 50EDs before screening can be obtained;

          -  HIV negative; if HIV positive, the viral load <200 particles/uL or <400,000 copies/mL,
             and HIV patients must satisfy CD4+ count >200/μL;

          -  The patient or his guardian voluntarily signed the Informed Consent Form.

        Exclusion Criteria:

          -  Known allergy to any coagulation factor VIII or any excipient; known allergy to
             bovine, rodent or hamster bovine;

          -  Has a history or family history of blood coagulation factor VIII inhibitor;

          -  Patients with other coagulation dysfunction diseases in addition to hemophilia A;

          -  Patients with other clinically significant diseases, alcoholism, drug abuse, mental
             disorders or intellectual disabilities;

          -  Patients with other severe or clinical significant diseases verified by the
             investigator to be unable to benefit from the clinical study;

          -  Patients who participated in other clinical studies within one month before the first
             drug administration (except FVIII trials) and patients who participated in other FVIII
             clinical trials after signing the Informed Consent Form;
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Assessment of Giant Cell Arteritis Medical Practices in France (NCT03658889)

Eligibility criteria:
Inclusion Criteria:

          -  At least 50 years old.

          -  Suffering from GCA as per investigator judgement, newly diagnosed or not.

          -  Starting or under treatment for GCA.

          -  Informed verbally and in writing about this study and not objecting to their data
             being electronically processed or subjected to data quality control.

        Non-inclusion Criteria:

          -  Unable to consent

          -  Participation to a randomised controlled clinical trial
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: Clinical Trial for High Intensity Laser Therapy (HILT) for Elbow Epicondylosis (NCT01992627)

Eligibility criteria:
Inclusion Criteria:

          -  history of medial and lateral elbow pain for at least three months in duration

          -  local tenderness for at least three months in duration

          -  pain on the epicondyle upon active resistive flexion (medial) and extension (lateral)
             of the wrist

        Exclusion Criteria:

          -  previous elbow conservative managements such as physical therapy and elbow
             injection-based therapies

          -  previous surgical management of the elbow
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Dose Response Study of Patients With Erythematous Rosacea (NCT01186068)

Eligibility criteria:
Inclusion Criteria:

          -  male or females at least 18 years of age

          -  diagnosis of stable erythematous rosacea

          -  < 3 inflammatory lesions

          -  in good general health

          -  females must be non-pregnant and non-lactating

          -  must be willing to sign a consent form

        Exclusion Criteria:

          -  have ocular, phymatous or other types of rosacea

          -  allergy to any ingredient in study drug

          -  participation in other investigational studies within 30 days of enrollment

          -  use of systemic steroids within 28 days of Baseline

          -  use of tetracycline antibiotics within 28 days of baseline

          -  use of products containing oxymetazoline within 14 days of baseline

          -  use of topical steroids witin treatment area 14 days prior to baseline

          -  use of Rx or OTC products for treatment of acne or rosacea within 14 days of baseline

          -  use of any product for reducing redness within the treatment area witin 14 days prior
             to baseline

          -  use of monoamine oxidase (MAO) inhibitors

          -  use of niacin >/= 500mg/day
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Cryopreservation of Ovarian Cortex in Girls With Turner Syndrome (NCT01410045)

Eligibility criteria:
Inclusion criteria :

          -  girls aged from 1 to 25 years included,

          -  with Turner syndrome or mosaic

          -  patients aged more than 18 will only have ovarian insufficiency dated less than 5
             years

          -  without any severe disease, particularly of cardiovascular type

          -  whose agreement to participate to the study has been signed by the parents

          -  whose agreement to participate to the study has been signed by majority age patient

        Exclusion criteria :

          -  girls aged less than one year and over 25 years old

          -  if any surgery would be contra-indicated

          -  ovary alone presence

          -  Well-known infection by HIV, and/or HBV, and/or HCV and/or syphilis TPHA VDRL

          -  No social coverage affiliate
Female
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 25 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of a 6-Months Physical Conditioning Program in Patients With Cystic Fibrosis (NCT00231686)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of cystic fibrosis

          -  Able to engage in intense physical activities

        Exclusion Criteria:

          -  FEV1 <35%predicted

          -  Esophageal varicosis

          -  Pulmonary bullae

          -  Drop in arterial oxygen saturation with exercise <80%

          -  Non-CF related chronic diseases

          -  Signs of pulmonary hypertension (ECG and echocardiogram)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Impact of Another Person's Presence on Brain and Behavioral Performance (NCT03453216)

Eligibility criteria:
Inclusion Criteria:

          -  Girl or boy aged ≥ 8 years and ≤ 12 years old for children,

          -  Girl or boy aged ≥ 13 years and ≤ 19 years old for teenagers,

          -  Woman or man age ≥ 20 years and ≤ 35 years old for young adults,

          -  French mother tongue,

          -  With the right to a social security scheme or similar,

          -  With informed consent form signed by the legal representatives and the subject, for
             minors,

          -  Has signed the informed consent form, for adults.

        Exclusion Criteria:

          -  Known acquired neurological disorders, including epilepsy,

          -  Known psychiatric disorders,

          -  Complications at birth requiring admission to neonatal intensive care unit,

          -  Ongoing treatment with drugs affecting the central nervous system,

          -  Significant hearing impairment,

          -  Uncorrected visual inadequacy,

          -  Left manual preference,

          -  Contraindications to the MRI examination (people using a pacemaker or an insulin pump,
             people wearing a metal prosthesis or an intracerebral clip as well as claustrophobic
             subjects),

          -  Refusal of the subject or parents of the subject to be informed of any anomalies
             detected on the MRI,

          -  Pregnancy for women of childbearing age: the possibility of pregnancy will be ruled
             out on questioning for inclusion,

          -  Protected persons other than children
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Endoscopic Resection in Gastro-Esophageal Reflux Disease (NCT03357809)

Eligibility criteria:
Inclusion Criteria:

          -  Patient with GERD resistant to medical treatment, or requiring daily long-term medical
             treatment

        Exclusion Criteria:

          -  Contraindications to the realization of a upper GI endoscopy

          -  Achalasia or other esophageal motor disorders

          -  Voluminous hiatal hernia Haemorrhagic, haemostasis or coagulation disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: National Survey of Essential Tremor Plus in China (NCT04837079)

Eligibility criteria:
Inclusion Criteria:

        Patients diagnosed with ET and/or ET-plus by the Consensus Statement on the Classification
        of Tremors, from the Task Force on Tremor of the International Parkinson and Movement
        Disorder Society.

        Exclusion Criteria:

        Lack of capacity to consent to participate in the project
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Laparoscopic Versus Open Repair of Bilateral Primary Inguinal Hernia (NCT04357665)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with primary bilateral inguinal hernias in patients aged from 20 to 60 years

        Exclusion Criteria:

          1. - Immune compromised patients,

          2. - Morbid obesity (BMI > 35 kg/m2)

          3. - Chronic liver or renal disease

          4. - Coagulopathy

          5. - High-risk patients unfit for major surgery (ASA III or IV)

          6. - Recurrent hernias

          7. - Complicated hernias

          8. - Massive scrotal hernias

          9. - Previous infra-umbilical surgery

         10. Persistent groin pain due to other causes
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction