araag2/NLI4PR huggingface dataset:
Clinical trial: Pleural Ultrasonography in Lung Cancer (NCT01141946)

Eligibility criteria:
Inclusion Criteria:

          -  Lung lesion being evaluated for surgery during initial consultation with a thoracic
             surgeon

        Exclusion Criteria:

          -  Age < 18 years old

          -  Inability to consent for the study

          -  Chest wall anatomy precluding PULC

          -  Inability to sit upright

          -  Medications including Warfarin (Coumadin) or Clopidogrel (Plavix) in patient requiring
             pleural fluid aspiration

          -  Active cutaneous infection overlying proposed puncture site
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of Different Prophylaxis Regimens for Moderate to Severe Hemophilia A Pediatric Patients (NCT02727647)

Eligibility criteria:
Inclusion Criteria:

          -  Hemophilia patients with moderate (factor level 1-3%) or severe (factor level <1%)
             severity

        Exclusion Criteria:

          -  Platelet count less than 100,000 /mm3 or other bleeding tendency

          -  Hemophilia patients who have FVIII inhibitor >0.6 BU (modified Nijmogen method)

          -  Hemophilia patients who have no bleeding symptoms
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Months old.
Subject must be at most 20 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Vertebroplasty for the Treatment of Fractures Due to Osteoporosis (NCT00068822)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed osteoporosis or osteopenia by a referring physician and/or medical history
             and physical exam OR osteopenia on plain film

          -  Vertebral compression fracture in vertebrae T4 through L5, of less than 1 year old

          -  Pain not responsive to standard medical therapy

          -  Current rating for pain intensity of at least 3 on a scale of 0 to 10

        Exclusion Criteria:

          -  Evidence or suspicion of malignant tumor or spinal canal compromise

          -  Concomitant hip fracture

          -  Local or systemic infection

          -  Uncorrectable bleeding diatheses

          -  Surgery within the previous 60 days

          -  Lack of access to telephone

          -  Inability to communicate in English

          -  Dementia

          -  Pregnancy

          -  Abnormal renal function or anticipated venography

          -  Conscious sedation is contraindicated for subject
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Intraspinal Transplantation of Autologous ADRC in ALS Patients (NCT03296501)

Eligibility criteria:
Inclusion Criteria:

          -  clinically definite or probable ALS according to El Escorial criteria

          -  life expectancy of more than 1 year

          -  INR ≤2 before liposuction

          -  lack of treatment with immune-suppressants and/or corticosteroids within min. 20 days
             prior to recruitment

          -  constant riluzole treatment (50 mg/bid) throughout the study period

          -  compliance with treatment regimen e.g. will and possibility to attend check-up visits

          -  Polish citizens

        Exclusion Criteria:

          -  primary haematological disease, including hypercoagulable states

          -  Presence of comorbidity that would stand in the way of neurosurgical treatment-

          -  previous history of a spinal-cord surgery at the clinically affected level

          -  previous/current history of neoplasm or comorbidity that could impact upon patient's
             survival

          -  PEG

          -  pregnancy /lactation

          -  noninvasive/invasive mechanical ventilation at time of recruitment

          -  alcohol abuse, cocaine amphetamine, etc.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Is Anesthetic Loss of Consciousness a Top Down or Bottom up Phenomenon. What Does the Neurologic Examination Say?. (NCT03140982)

Eligibility criteria:
Inclusion Criteria: ASA 1-2 patients programmed for elective surgery, normal neurologic
        examination -

        Exclusion Criteria: neurologic illness, receiving drugs that affect Central Nervous System
        during the last 48 hours

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Contradiction
Clinical trial: Exercise and Physical Fitness for Persons With Knee Osteoarthritis (NCT00265447)

Eligibility criteria:
Inclusion Criteria:

        community-dwelling, physician diagnosed osteoarthritis of the knee, willingness to exercise
        regularly, willingness to perform 3 testing sessions over a 6-month period, ability to
        exercise safely at a moderate level of intensity, knee osteoarthritis by clinical criteria,

        WOMAC Scores as follows:

        PAIN:"mild" pain on 2 items or "moderate" pain on 1 item; PHYSICAL FUNCTION: "mild"
        difficulty in 4 items or "moderate" difficulty in 2 items -

        Exclusion Criteria:

        age<50,inability to exercise and ambulate independently, physical limitation secondary to a
        condition that is not modifiable by exercise (e.g., active cancer), knee replacement (past
        or scheduled), total hip joint replacement less than 6 months ago, current participation in
        regular conditioning exercise, participation in another research study,

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Biochemical Markers of Growth Response to Growth Hormone Treatment in Children With Idiopathic Short Stature (NCT00458263)

Eligibility criteria:
Inclusion Criteria:

          -  Ages 3 to <9 years

          -  Short stature with height >2.25 Standard Deviation below the mean

          -  Prepubertal (Tanner stage I) at commencement of trial

          -  Peak Growth Hormone above 10ng/ml in at least one provocative test for Growth Hormone
             secretion

          -  Signing informed consent forms

        Exclusion Criteria:

          -  Intra Uterine Growth Retardation

          -  Growth retardation associated with malignancy, severe chronic disease, genetic
             syndromes and endocrine disorders

          -  Diabetes

          -  Treatment with any medical product which may interfere with Growth Hormone
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 9 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pain in Patients With Congenital Coagulopathies (NCT03499522)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with medical diagnosis of congenital coagulopathies: hemophilia A, hemophilia
             B, or von Willebrand's disease

          -  Patients over 18 years of age

          -  Patients in a prophylactic or on demand regimen with FVIII / FIX concentrates

          -  Patients that have accepted the informed consent document.

        Exclusion Criteria:

          -  Patients with neurological or cognitive disorders that prevent the comprehension of
             the questionnaires

          -  Patients without capacity to walk autonomously or with orthosis

          -  Patients without access to digital media to complement the measuring instruments.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison Between Positive and Negative COVID-19 Pneumonia (NCT04507893)

Eligibility criteria:
Inclusion Criteria:

        All consecutive patients referred to the Emergency Unit of the "V. Cervello" Hospital, in
        Palermo, Italy, for clinical symptoms suggestive of suspected COVID-19 infection.

        In details, we consider patients referred for one or more of the following manifestations:
        respiratory symptoms, fever, taste or smell loss.

        To be included their records must include:

          -  detailed clinical history

          -  radiological findings (High-resolution CT, HRCT)

          -  results of viral RNA research for SARS-COV2, by PCR on nasopharyngeal swab, repeated
             two times (at the admission and again after 48 hours from the admission in the
             Emergency Unit)

          -  laboratory results regarding routine hemato-chemical assays

          -  oxygen therapy

          -  treatment used.

        Exclusion Criteria:

          -  age <18 years

          -  incomplete medical records with respect to the parameters sought
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 95 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Relationship Between PFTs and Pdi in DMD (NCT03335384)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Duchenne muscular dystrophy

        Exclusion Criteria:

          -  Inability to follow verbal instructions
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 25 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment