araag2/NLI4PR huggingface dataset:
Clinical trial: A Study to Test if TVB-009P is Effective in Relieving Postmenopausal Osteoporosis (NCT04729621)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal womeen (≥60 and ≤90 years) with a diagnosis of osteoporosis

          -  Body weight ≥50 kg and ≤90 kg

          -  Bone Mineral Density (BMD) measurement T score of less than 2.5 but not less than 4.0
             by dual-energy X-ray absorptiometry (DXA) at the lumbar spine at screening

          -  At least 3 vertebrae in the L1 L4 region that are evaluable by dual-energy X-ray
             absorptiometry (DXA)

        Exclusion Criteria:

          -  One severe or more than two moderate vertebral fractures

          -  History and/or presence of hip fracture or atypical femur fracture

          -  Any prior treatment with denosumab

          -  Ongoing use of any bone active drugs which can affect Bone Mineral Density (BMD)

          -  Vitamin D deficiency or hyper- or hypocalcemiacium at screening

          -  Hyperthyroidism, hypothyroidism, hypoparathyroidism or hyperparathyroidism

          -  Any medical condition that could jeopardize or would compromise the patient's safety
             or ability to participate in this study

        Other Inclusion/exclusion criteria may apply
Female
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Registry for Clinical Presentation and Management of Patients With COVID-19 in the Emergency Room (NCT04351854)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical suspicion or evidence of SARS-CoV-2-infection on presentation in the ED

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Antibody Response to Influenza Vaccine in Patients With Sarcoidosis (NCT00828828)

Eligibility criteria:
Inclusion Criteria:

        Sarcoidosis patients:

          -  Patients with relevant clinical, radiologic and histologic features of sarcoidosis
             (all stages).

          -  Signed informed consent.

        Exclusion Criteria:

          -  Organ failure (kidney, heart, liver).

          -  Collagen vascular diseases.

          -  Diabetes.

          -  Contraindications of vaccine (Egg allergy).

          -  Patients who receive high dose (> 60 mg/day) steroid therapy.

          -  Any acute disease.

          -  Conditions accompanied by immunosuppression (like organ transplantation, HIV).

          -  Any psychological disease that interferes with regular follow-up.

          -  Inoculation with influenza vaccine within the past 5 years.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? Entailment
Clinical trial: Identification of Biomarkers for Prediction of Response or Resistance Against Target Therapy in Gastric Cancer (NCT02305043)

Eligibility criteria:
Inclusion Criteria:

          -  histologically proven adenocarcinoma of the stomach or gastroesophageal junction

               -  stage IV

               -  patient receives chemotherapy

               -  signed informed consent

               -  Age > 18 years

        Exclusion Criteria:

          -  Patient can not understand meaning and purpose of the study

          -  patient already received a chemotherapy treatment for advanced disease.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: New Treatments for Troublesome Bleeding in Implanon Users (NCT01384331)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women aged 18-45 using the subdermal progestogen-only contraceptive implant
             and experiencing frequent or prolonged vaginal bleeding Willing to keep a menstrual
             diary for 6 months

        Exclusion Criteria:

        Women who have currently or previously had

          -  Heart attack or stroke

          -  Blood clot in a vein

          -  High blood pressure

          -  Severe liver or kidney disease

          -  Blood pressure > 135 mm systolic or >85 mm diastolic

          -  Migraine with aura

          -  Breast cancer or any genital cancer

          -  Severe chronic liver or kidney disease

          -  Women with known sensitivity to ethinyl oestradiol, progestogens

          -  Women taking phenytoin, carbamazepine or phenobarbitol

          -  Women who are pregnant

          -  Women who are lactating

          -  Women who are unwilling to keep a daily menstrual diary or otherwise unwilling to
             follow the study criteria
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Investigation of Heart Rate Variability During the Menstrual Cycle (NCT04008277)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years and over

          -  Regular menstrual cycles

        Exclusion Criteria:

          -  Taking any hormonal medications

          -  Taking any medications that may affect heart rate

          -  Known heart condition or use of a pacemaker

          -  Skin condition where there is sensitivity to wearing a skin monitor

          -  Currently suffering with anxiety or panic attacks

          -  Pregnant or breastfeeding
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy of Tart Cherry Juice to Reduce Pain and Inflammation Among Patients With Inflammatory Osteoarthritis (NCT01073982)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with inflammatory osteoarthritis

          -  In good general health

          -  Stable pattern of anti-inflammatory or pain relieving drug use for 3 months prior to
             study

          -  Ability and willingness to maintain consistent pattern of anti-inflammatory or pain
             relieving drug use during the course of the study, and to not seek any other treatment
             during the study

          -  Ability and willingness to consume juice or placebo drink for 21 consecutive days, and
             to participate in screening measures, including a blood draw, before and after the
             intervention period

        Exclusion Criteria:

          -  Pregnancy

          -  Serious medical conditions such as recent heart attack or stroke, cancer, diabetes
             (type 1 and type 2), or gastrointestinal ulcers

          -  Individuals who have not been on a stable dose of pain medications or pain modalities
             for at least 3 months, including muscle relaxants, tender point anesthetic injections,
             systemic or intrabursal or intraarticular steroids, or any investigational drug/device
             in the prior 90 days

          -  Individuals who have used nonpharmacologic pain therapies including acupuncture,
             ultrasound, or transcutaneous electrical nerve stimulation within the past 30 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Concentrate of Autologous Rich Plasma in Growth Factors in the Treatment of the Thin Endometrium (NCT03387501)

Eligibility criteria:
Inclusion Criteria:

          -  Women who signed informed consent.

          -  Women who understand the Spanish language.

          -  Women under 40 years

        Exclusion Criteria:

          -  Thrombopenia.

          -  Congenital or acquired uterine malformations that reduce embryo implantation or term
             gestation.

          -  Ovarian tumors.

          -  Benign uterine tumors require surgical treatment

          -  Local acute inflammatory diseases

          -  Patients with malignant tumors requiring chemotherapy.

          -  Patients with acute or chronic infectious or inflammatory diseases requiring active
             treatment with drugs that may interfere with implantation and gestation.

          -  Chronic treatment with NSAIDs (Nonsteroidal anti-inflammatory drugs)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Entailment
Clinical trial: Investigating the Involvement of ACE and Angiotensinogen Genes' Polymorphism Along With Other Thrombophilic Genotypes in Severe Forms of COVID-19 With/Without Thrombotic Events (NCT04519398)

Eligibility criteria:
Inclusion Criteria:

          -  All hospitalized patients with cough, fever, myalgia - with confirmed COVID-19
             infection • All patients with a positive SARS-CoV-2 PCR test

        Exclusion Criteria:

          -  Patient refusal

          -  Uncertain tests results

          -  Children
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Randomized, Double-blind, Placebo-controlled, Dose Response Study of AMG 162 (Denosumab) in Japanese Postmenopausal Osteoporotic Subjects (NCT00306189)

Eligibility criteria:
Inclusion Criteria: - Ambulatory postmenopausal women. - BMD values (g/cm2, Hologic) must
        be lower than 0.714 at lumbar spine, 0.515 at femoral neck, 0.588 at total hip. - BMD
        values must not be lower than 0.535 at the lumbar spine, 0.406 at the femoral neck and
        0.478 at the total hip. Exclusion Criteria: - Oral bisphosphonate treatments, PTH or PTH
        derivatives use within the last 12 months and administration of any of anti-osteoporotic
        treatments within the last 3 months before initial administration of the investigational
        product. - History of hypocalcemia. - More than two moderate vertebral fractures or any
        severe vertebral fracture.
Female
No healthy subjects accepted to join the trial.

Subject must be at most 80 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction