araag2/NLI4PR huggingface dataset:
Clinical trial: Ultrasound-guided Genicular Nerve Block With Phenol for the Treatment of Chronic Pain Due to Knee Osteoarthritis (NCT03601533)

Eligibility criteria:
Inclusion Criteria:

          -  Signature of the free, informed consent form

          -  Age over 18 years old

          -  Knee pain for more than six months without improvement with clinical treatment

          -  Clinical and imaging diagnosis (radiography) of knee osteoarthritis

          -  Moderate pain intensity (pain greater than 4, by the numerical scale).

        Exclusion Criteria:

          -  Cognitive impairment or psychiatric disease

          -  Other causes of knee pain (trauma, complex regional pain syndrome)

          -  Puncture site infection

          -  Coagulopathy or use of anticoagulant.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Long-Term Growth and Skeletal Effects of Early Growth Hormone Treatment in Turner Syndrome (NCT00266656)

Eligibility criteria:
Inclusion Criteria:

          -  Previously randomized in study B9R-US-GDFG (NCT00406926)

          -  Karyotype-proven Turner syndrome

        Exclusion Criteria:

          -  Immediate family members of study site personnel directly affiliated with the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 20 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study to Assess the Bioequivalence of Famotidine/Antacid Combination Tablets Compared to Famotidine/Antacid EZ Chew Tablets (0208C-145)(COMPLETED) (NCT00944671)

Eligibility criteria:
Inclusion Criteria:

          -  Female subject is not pregnant or lactating, Females of childbearing potential must
             use reliable means of contraception during the course of the study

          -  Subject is in good health

          -  Subject is able to abstain from smoking during the 24-hour periods before and during
             each treatment day

        Exclusion Criteria:

          -  Subject has a history of stomach ulcers, other Gastrointestinal (GI) diseases or GI
             surgery

          -  Subject has a history of asthma or severe allergies to drugs or foods

          -  Subject currently uses prescribed or nonprescribed drugs on a regular basis

          -  Subject has a recent history of drug/alcohol abuse

          -  Subject consumes more than 6 cups of coffee per day

          -  Subject has unconventional or extreme dietary habits

          -  Subject has donated blood or has been in a clinical trial in which they received an
             investigational drug during the past 30 days

          -  Subject has a history of allergy or intolerance to antacids

          -  Female subject is known to be pregnant or is not using reliable means of contraception
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: The Role of Sodium Bicarbonate as Adjuvant Treatment of Computed Tomography Identified COVID-19 Pneumonia (NCT04374591)

Eligibility criteria:
Inclusion Criteria:

          -  Age >18 years.

          -  Fever ≥ 38º C with upper respiratory tract manifestations, generalized bone ache with
             or without gastrointestinal symptoms as diarrhea.

          -  Chest CT with signs suggestive of COVID-19.

          -  Mild and moderate cases of COVID-19 pneumonia with respiratory and hemodynamic
             stability. - High C reactive protein (CRP).- With or without history of contact with
             index case who is isolated in a governmental hospital assigned for treatment of
             patients proved to have RT-PCR positive test for COVID-19

          -  With or without abnormalities in the total or differential white cell count.

          -  Welling to sign a fully informed consent.

        Exclusion Criteria:

          -  Severe and critical illness with respiratory failure and/ or hemodynamic instability.

          -  CT with pleural effusion with or without lung cavitation.

          -  Other organ failure.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Physical Therapy Management in Degenerative Lumbar Diseases and Osteoporosis (NCT01703403)

Eligibility criteria:
Experimental group:

        Inclusion Criteria:

          -  patients with the diagnosis including lumbar spondylosis, low back pain, osteoporosis,
             compression fracture, back pain treated at National Taiwan University Hospital

          -  received rehabilitation at the Physical Therapy Center in recent ten years.

        Control group:

        Inclusion Criteria:

          -  patients with the diagnosis including lumbar spondylosis, low back pain, osteoporosis,
             compression fracture, back pain treated at National Taiwan University Hospital

          -  not received rehabilitation at the Physical Therapy Center in recent ten years.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Changes in Radicular Pain and Pain Modulation (NCT04193969)

Eligibility criteria:
Inclusion Criteria:

        Patient group

          -  Radiating leg pain due to nerve root compression verified by MRI

          -  Clinical findings in accordance with MRI findings

          -  Average leg pain ≥ 3/10 on a numeric pain rating scale Controls

          -  No current or previous history of ongoing musculoskeletal pain

        Exclusion Criteria:

        Applies for both groups.

          -  Other specific medical conditions e.g. rheumatologic disease, diabetes or vascular
             diseases.

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient description (patient's own words): I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Does the patient match the trial criteria? Entailment
Clinical trial: Tranilast Plus Allopurinol in Patients With Moderate to Severe Gout (TAnGO) (NCT01109121)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female, aged 18 to 80

          -  Severe gout, demonstrated by 3 or more gout flares in the previous 12 months, or the
             presence of at least one gout tophus or gouty arthritis

          -  Hyperuricemia with a sUA ≥8.0 mg/dL

        Exclusion Criteria:

          -  Pregnant or nursing

          -  Known hypersensitivity to any of the components of tranilast or allopurinol

          -  Known history of xanthinuria or kidney stones

          -  Use of an investigational drug within 30 days

          -  Presence of, or history of, cancer with the exception of completely excised,
             non-metastatic squamous cell and basal cell carcinomas of the skin

          -  Subject is planning or likely to require a surgical procedure during the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effect of Kinesiotaping on Wrist Kinematics and Functional Performance (NCT03788954)

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent form and participated in all stages of the study

          -  Being in the age range of 18-25

          -  Being right-handed

        Exclusion Criteria:

          -  Having physical, mental disability (vision, hearing, etc.) which may affect
             participation in the study

          -  Presence of a history of congenital or acquired orthopedic, neurological, or rheumatic
             disease that may impair joint range and / or function of the hand and wrist

          -  Having a history of trauma requiring medical, conservative and surgical treatment for
             the application area in the last 6 months

          -  Presence of skin lesions (burns, cellulite, vesicles, bulla, pisoriasis, open / closed
             wound, scar, active infection, malignancy, etc.) in the application area.

          -  Excessive skin reaction to applications

          -  The problem of hirsutism to the extent of preventing the kinesiotaping in the
             application area.

          -  Dart sports experience as amateur or professional

          -  To have consumed alcohol, pharmaceutical substance until 24 hours before the
             evaluation

          -  Using anabolic substance

          -  To have theoretical and practical experience in Kinesio taping

          -  Being obese
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 25 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Mi-iron - Moderately Increased Iron - is Reducing Iron Overload Necessary? (NCT01631708)

Eligibility criteria:
Inclusion Criteria:

          1. HFE C282Y homozygous.

          2. Aged 18 - 70 years .

          3. SF above the upper limit of the normal range of 300µg/L but less than 1000µg/L with a
             currently or previously raised TS (>greater than the upper limit of normal for the
             testing laboratory).

        Exclusion Criteria:

          1. HH due to genotypes other than HFE C282Y homozygosity.

          2. Normal SF, SF > 1000µg/L.

          3. Other major risk factor(s) for liver toxicity or other significant co-morbidities
             including positivity for hepatitis B or C, excess alcohol consumption (> 60g/day in
             males and 40g/day in females) or body mass index > 35.

          4. Has had venesection therapy for HH in the last two years.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment
Clinical trial: Simultaneous OCT and B-FAF in Eyes With Alteration of the Foveal Contour (NCT03287648)

Eligibility criteria:
Inclusion Criteria:

          -  alteration of the foveal contour not classifiable as lamellar or pseudo macular hole

          -  focal, well-defined increased autofluorescence signal at the fovea

        Exclusion Criteria:

          -  intraretinal cysts not associated with break of the inner retina

          -  juxtafoveal telangiectasia

          -  ring of increased B-FAF

          -  vitelliform and pseudovitelliform lesions

          -  history of diabetes, retinal vein occlusion, uveitis, CSR, AMD or any other retinal
             -disease potentially associated with intra or subretinal fluid

          -  macular drusen

          -  history of submacular hemorrhage
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? Contradiction