araag2/NLI4PR huggingface dataset:
Clinical trial: Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's Disease (NCT00939822)

Eligibility criteria:
Inclusion Criteria:

          -  Parent diagnosed with Alzheimer's disease

          -  Age 40-72

        Exclusion Criteria:

          -  Active liver disease

          -  History of adverse reaction to statins

          -  Contraindication to lumbar puncture

          -  Elevated creatine kinase and creatinine lab values

          -  Use of medications known to interact with statins

          -  History of dementia or mild cognitive impairment

          -  Currently pregnant or planning to become pregnant

          -  Use of large quantities of grapefruit juice (more than 1 quart per day)

          -  Contraindications to MRI (for MRI sub-study)

          -  Currently on cholesterol-lowering medication or use in past 4 months

          -  History of heart attack, heart problems, stroke and/or diabetes

          -  Drinking more than a quart of grapefruit juice per day

          -  Metal implants, or metal debris in body (MRI)

          -  List of medications that interact with simvastatin
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 72 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Impact of Sleep Disruption on the Menstrual Cycle (NCT00456222)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy

          -  Regular menstrual cycles

        Exclusion Criteria:

          -  No medications affecting the menstrual cycle or sleep
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 30 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Investigation of the Proportion of Human Epidermal Growth Factor Receptor 2 Protein Overexpression of Gastric Adenocarcinoma and Prognostic Effect of HER2, and Analysis of Practice Pattern of Herceptin Use in Stage IV Gastric Cancer (NCT02136836)

Eligibility criteria:
Inclusion Criteria:

          1. Histologically confirmed gastric adenocarcinoma

          2. Patients were diagnosed during 2006-2013

          3. HER2 expression status was evaluated in primary gastric cancer or metastatic lesion.

        Exclusion Criteria:

          -  Patients with second primary cancer within 5 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Multistability: Perception is Inspired by Noise (NCT03723044)

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent

          -  Medical examination carried out before the participation in the research

          -  Age between 18 and 55 years

          -  Minimum level of studies

          -  Obligation to join the social security system

          -  normal or corrected vision normal

        Exclusion Criteria:

          -  Subject included in another clinical and / or therapeutic experimentation in progress

          -  Major vision disorder

          -  Past or current neurological or neuropsychiatric pathologies

          -  History of cranial trauma with loss of consciousness.

          -  Medication treatments likely to modulate brain activity: benzodiazepine,
             antidepressants, neuroleptics, lithium, etc.

          -  Diabetes, cardiac pathology, immunodeficiency.

          -  Medication treatments likely to modulate the activity of the cardiovascular system.

          -  History of abuse or recent ingestion of alcohol, hard drugs or doping products.

          -  Consumption of more than 15 cigarettes per day

          -  Subject deprived of liberty by a judicial or administrative decision (L1121-6 CSP)

          -  Major subject subject to a legal protection measure or unable to express their consent
             (L1121-8 CSP)

          -  Pregnant, parturient and nursing mothers (L1121-5)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: Soft Drinks and Osteoporosis in WHI Participants (NCT03371433)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women

          -  More than one day of follow up

          -  Dietary information on soft drinks

        Exclusion Criteria:

        Previous hip fracture
Female
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 79 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Clinical Study of Cochlear Implants in Adults With Asymmetrical Hearing Loss (NCT02004535)

Eligibility criteria:
Inclusion Criteria:

          -  18 years of age or older at time of surgery

          -  The poorer ear (implant ear) will have a severe-to-profound hearing loss and meet
             current cochlear implant candidacy criteria.

          -  The better ear (contralateral ear) will have hearing levels less than current cochlear
             implant candidacy criteria and stable/non-fluctuating hearing levels for at least the
             previous year

          -  Normal/patent cochlear anatomy

          -  Fluent in English

          -  Desire to have more functional binaural hearing and willingness to comply with all of
             the study requirements

        Exclusion Criteria:

          -  Medical or psychological conditions that contraindicate undergoing surgery

          -  Additional handicaps that would prevent or restrict participation in the audiological
             evaluations

          -  Ossification or any other cochlear anomaly that might prevent complete insertion of
             the electrode array

          -  Hearing loss of neural or central origin, including auditory neuropathy

          -  Chronic and severe tinnitus in the ear to be implanted

          -  Unwillingness or inability to comply with all investigational requirements
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment
Clinical trial: The Effect of the Oligofructose Supplementation on Body Weight in Overweight and Obese Children (NCT01673152)

Eligibility criteria:
Inclusion Criteria:

          -  Children aged 7 to 18 years

          -  BMI > 85 percentile

          -  Signed informed consent

        Exclusion Criteria:

          -  Overweight / obesity secondary to genetic syndromes and/or endocrine diseases
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Reliability, Validity of the Turkish Version of the Primary Sjögren Syndrome Quality of Life (PSS-QoL) Questionnaire (NCT04858464)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with primary Sjögren's syndrome

        Exclusion Criteria:

          -  Having neurological and cognitive disorders,

          -  Having another rheumatological diseases
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy of Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis. (NCT03379168)

Eligibility criteria:
Inclusion Criteria:

          -  Age of eighteen or older

          -  Diagnosis of symptomatic knee osteoarthritis

          -  Radiographic evidence of knee osteoarthritis. Note: For the purposes of this study,
             radiographic evidence of knee osteoarthritis is defined as any one or more of the
             following: osteophytes, joint space narrowing, loss of articular cartilage thickness,
             subchondral sclerosis or cysts.

        Exclusion Criteria:

          -  History of treatment with any intra-articular knee injection

          -  Current ligament instability as demonstrated by a positive Lachman Test, Anterior or
             Posterior Drawer Test, or positive Valgus or Varus Stress Test.

          -  Known allergy to lidocaine

          -  Under 18 years of age

          -  Pregnant women

          -  Prisoners
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: A Tiered Management System of Osteoporosis in China (NCT03916289)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women or men aged 50 years or older

        Conform to the diagnosis of osteoporosis or osteopenia as followings:

          1. Bone mineral density measured by dual-energy X-ray absorptiometry show a T-score ≤
             -1.0 at neck of femur or total hip or lumber 1-4 OR

          2. Have at least once major osteoporotic fracture

        Exclusion Criteria:

          -  Screened people who do not meet the inclusion criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment