araag2/NLI4PR huggingface dataset:
Clinical trial: Caplacizumab Single and Multiple Dose Study in Healthy Japanese and White Subjects. (NCT03172208)

Eligibility criteria:
Inclusion Criteria:

          -  BMI between ≥18 kg/m² and <30 kg/m² at time of screening

          -  Body weight between ≥45 kg and <100 kg

          -  Baseline vWF:Ag between ≥60% and <170% (0.6-1.7 IU/mL)

        Exclusion Criteria:

          -  History of and/or any sign or symptom indicating current abnormal hemostasis or blood
             dyscrasia, including but not limited to thrombocytopenia, thrombocytopathy,
             thromboasthenia, hemophilia, von Willebrand's disease, vascular purpura, bleeding gums
             and/or frequent nose bleeding, easy/spontaneous bruises, meno- or metrorrhagia,
             history of gastrointestinal bleeding or excessive bleeding after minor injury such as
             shaving.

          -  Family history of congenital vascular malformation (e.g., Marfan's Syndrome) and/or
             bleeding disorder (e.g., hemophilia, von Willebrand's disease, Christmas disease)

          -  Any surgical intervention (including tooth extraction) or trauma within the 4 weeks
             preceding screening for the study or any planned surgical intervention during the
             participation in the study

          -  Treatment with vitamin K, direct oral anticoagulant (DOAC), warfarin, high dose
             heparin within 2 weeks before screening
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Contradiction
Clinical trial: Nasal LPS Challenge in Healthy Volunteers (NCT02284074)

Eligibility criteria:
INCLUSION CRITERIA

          -  Males and females aged 18 to 60 years

          -  Current non-smokers for last 6 months (<5 cigs per week), with a smoking history of <5
             pack years

          -  BMI 20-30 kg/m2

        EXCLUSION CRITERIA

          -  History of allergy

          -  Upper airway infection in 2 weeks before screening

          -  Lower respiratory tract infection in past 3 months

          -  Treatment with local or systemic corticosteroids during previous 2 months

          -  Signs or symptoms of chronic rhinitis, hypertrophy of turbinates, major septum
             deviation, nasal polyposis or recurrent sinusitis

          -  Previous nasal or sinus surgery

          -  Clinically significant cardiovascular, hepatic, GIT, renal, endocrine, infective,
             haematological, neurological, dermatological, neoplastic conditions,
             gastro-oesophageal reflux, depression, TB

          -  Participation in a therapeutic drug trial in the prior 30 days.

          -  Medical therapy other than that permitted for contraception.

          -  Positive pregnancy test

          -  Inability or unwillingness to use contraception if the patient is a female of
             child-bearing age.

          -  History of drug abuse or urine test showing evidence of recreational drug abuse
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of SelfFit Mobile Medical App for Hearing Loss Diagnostics and Hearing Device Fitting / Fine Tuning (NCT01877317)

Eligibility criteria:
Inclusion Criteria:

          -  Hearing loss at the better ear between 35dB and 50dB (PTA1/2/4)

          -  Active lifestyle

          -  No language problems

          -  No medical contra-indications

          -  Age: between 18 and 75 years

          -  About 50% experienced users and 50% new users

          -  Willing to participate in the trial with one three hour visit to the AMC.

        Exclusion Criteria:

          -  Conductive hearing loss in the middle ear

          -  Severe hearing loss
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study to Assess the Efficacy, Safety and Tolerability of Tegaserod Alone and in Combination With Omeprazole Given Orally in Patients With Symptoms of Symptomatic Gastroesophageal Reflux Disease (sGERD) (NCT00149851)

Eligibility criteria:
Inclusion Criteria:

          -  History of physician diagnosed GERD

          -  Heartburn and Regurgitation 3 Days during the week prior to screening

        Exclusion Criteria:

          -  History of erosive esophagitis, Barrett's esophagus, esophageal stricture,
             scleroderma, Zollinger-Ellison Syndrome, known primary disorder

          -  History or presence of infection or inflammation of the small or large intestine,
             gastrointestinal malignancy, history of upper GI surgery

          -  Use of PPI during the last four weeks prior to screening

        Other protocol-defined inclusion/exclusion criteria may apply.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Chamaemelum Nobile 2% Versus Placebo Topic Gel to Treat Oral Lichen Planus (NCT02421770)

Eligibility criteria:
Inclusion Criteria:

          1. Patients clinically & histopathologically diagnosed to be suffering from oral lichen
             planus.

          2. Patients who had symptoms i.e. pain and/or burning sensation secondary to oral lichen
             planus.

          3. Patients not on any treatment for the same. In case they were, then such treatment was
             stopped and a washout period of two weeks was given.

        Exclusion Criteria:

          1. Patients suffering from any systemic disease/s like

          2. Patients with any other mucosal disease or any other skin disease which may be
             associated with oral lesions.

          3. Patients on any drug therapy which may cause lichen planus like lesions.

          4. Patients with findings of any physical or mental abnormality, which would interfere
             with or be affected by the study procedure.

          5. Patients with a known allergy or contraindication to study medications
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Eating Behavior in Adolescents (NCT00631644)

Eligibility criteria:
-  INCLUSION CRITERIA:

        Volunteers will qualify for participation in the study if they meet the following criteria:

          1. <TAB>Age 13-17 years.

          2. <TAB>Good general health as indicated by medical history and physical examination.

          3. <TAB>Negative urine glucose and normal electrolytes, hepatic, and thyroid function.

          4. <TAB>For the fMRI portion only: right handedness (required for standardization of
             responses).

          5. <TAB>For the fMRI portion only: female.

          6. <TAB>For the fMRI portion only: overweight (BMI greater than or equal to 85th
             percentile for age and sex).

        EXCLUSION CRITERIA:

        Volunteers will be excluded if they have any of the following:

          1. <TAB>Medical problem likely to affect caloric intake.

          2. <TAB>History of any condition including psychiatric disorders in either child or their
             responsible parent that in the opinion of the investigators would impede competence to
             sign consent, interfere with adherence to procedures, or possibly hinder completion of
             the study.

          3. <TAB>Pregnancy.

          4. <TAB>Use of medication likely to affect caloric intake.

          5. <TAB>History of significant neurological injury or insult.

          6. <TAB>For the fMRI portion only: braces (or other metal) that would interfere with the
             fMRI procedure.

          7. <TAB>For the fMRI portion only: non-native English speakers (required for
             standardization of responses).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 13 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Levamisole and Isoprinosine in the Treatment of COVID19: A Proposed Therapeutic Trial (NCT04383717)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed COVID 19 infection (positive PCR, elevated ESR, leucopenia)

          -  Clinical picture of COVID 19 infection including fever, malaise, sore throat,
             coughing, dyspnea, and runny nose

        Exclusion Criteria:

          -  Mild cases of COVID 19 that do not require hospitalization

          -  Pregnant & lactating women

          -  Children with other comorbidities

          -  People who received previous treatment for COVID 19 in the last 2 weeks N.B. Diabetes
             and hypertension not excluded
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 90 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Goal Achievement and Patient Satisfaction in Benign Hysterectomy (NCT02621710)

Eligibility criteria:
Inclusion Criteria:

          -  Patient undergoing hysterectomy for benign indication

          -  Age 18 or greater

          -  English speaking

          -  Access to communication via telephone

        Exclusion Criteria:

          -  Patient undergoing hysterectomy for malignant or pre-malignant condition

          -  Non-english speaking patient

          -  Patient without telephone access

          -  Patient undergoing emergent or unplanned hysterectomy

          -  Vulnerable populations
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: 'Fitness To Fly' Tests In Children With Type II Respiratory Failure (NCT03824223)

Eligibility criteria:
Inclusion Criteria:

          -  ≤18 years

          -  Neuromuscular weakness or central hypoventilation

          -  Established nocturnal or intermittent daytime ventilatory support

        Exclusion Criteria:

          -  Unable to sit in the plethysmograph

          -  Cardiac anomaly with right-to-left shunt
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: HMB- Data Collection Methods (NCT02001324)

Eligibility criteria:
Inclusion Criteria:

        Patients who are presenting for gynecologic visits or well-woman examinations who still
        have an intact uterus and are between the ages of 18 and 51 years, have abnormal uterine
        bleeding, and can read and write in English.

        Exclusion Criteria:

          -  Women who are presently on a treatment for abnormal uterine bleeding.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 51 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment