araag2/NLI4PR huggingface dataset:
Clinical trial: A Prospective Cohort Study for Patients With Adrenal Diseases (NCT03474237)

Eligibility criteria:
Inclusion Criteria:

          -  Adults, male or female aged 19 years or older

          -  newly diagnosed with adrenal disease such as adrenal incidentaloma, pheochromocytoma,
             primary aldosteronism, adrenal cushing syndrome, adrenocortical carcinoma

        Exclusion Criteria:

          -  previous or current history of adrenal diseases

          -  using oral or intravenous steroids

          -  history of major depressive disorder

          -  history of chronic alcoholics

          -  history of any cancer with suspicious adrenal metastasis

          -  those with acute illness (ex- patients with acute coronary syndrome within 4 weeks,
             acute febrile disease)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluation of the Role of Follicular Sensitivity Index in the Prediction of Pregnancy in Women Undergoing ICSI/IVF Without Polycystic Ovarian Syndrome (NCT02158026)

Eligibility criteria:
Inclusion Criteria:

          -  Both ovaries are present

          -  Day 2 FSH <10 mIU/L

          -  Day 2 Estradiol <50 pg/L

        Exclusion Criteria:

          -  Polycystic ovarian syndrome (PCOS)

          -  Abnormalities affecting the uterine cavity

          -  Uncontrolled diabetes

          -  Allergy to gonadotrophins

          -  Cancelled cycles during the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pulsed Dye Laser (PDL) vs. Microsecond 1064-nm Nd:YAG Laser for Treatment of Diffuse Facial Redness (NCT01529996)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy patients 18-55 years of age with erythematotelangiectatic rosacea (as verified
             by the the PI).

          -  Subjects who are willing to provide informed consent for participation in the study.

        Exclusion Criteria:

          -  Pregnant or lactating individuals

          -  Subjects who are unable to understand the protocol or to give informed consent.

          -  Subjects who have a known history of photosensitive conditions (e.g. Systemic lupus,
             polymorphous light eruption)

          -  Subjects who have facial telangiectasia of diameter greater than 2 mm.

          -  Subject who have significant (as determined by the PI) acute inflammatory papules,
             pustules, and vesicle involving the central face.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Degree-of-worry and Illness Perception in Patients Suffering From Acute Illness in the Emergency Department (NCT04226040)

Eligibility criteria:
Inclusion Criteria:

          -  ≥18 years of age

          -  cognitively intact

          -  consent to participation.

        Exclusion Criteria:

          -  patients arriving to the ED regarding injury

          -  patient with the highest triage level

          -  demented patients

          -  intoxicated patients
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Entailment
Clinical trial: Management of Acute Pain in the Emergency Department (NCT00470652)

Eligibility criteria:
Inclusion Criteria:

        Any patient admitted to our Emergency Department who is

          -  age > 16 years

          -  pain lasting =< 1 week or

          -  no pain on admission but pain during the ED stay

        Exclusion Criteria:

          -  life-threatening condition requiring immediate admission in the OR or ICU

          -  no pain or pain lasting >1 week

          -  inability to give informed consent (intoxicated, psychiatric disorder, language
             problem, prisoner)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Contradiction
Clinical trial: Impact of Probiotics on Oral Microbiota in Older Adults With Dysphagia (NCT03682094)

Eligibility criteria:
Inclusion Criteria

          1. 65 years of age or older

          2. Dysphagia diagnosis based on videofluoroscopic swallow study with observed airway
             invasion (Penetration-Aspiration Scale score of 3 or higher)

          3. Ability to provide consent

          4. Ability to submit oral samples

          5. Ability to swallow sachet of probiotic (dissolved in thickened liquid, as needed)

          6. Ability to return to UWHC for week 2 and week 4 visits.

        Exclusion Criteria

          1. Currently taking antibiotics or probiotics

          2. Actively receiving immunosuppressive therapy

          3. Non-oral feeding with inability to swallow probiotic

          4. diagnosis of head and neck cancer or upper airway disease

          5. prior surgery to the head and neck region that would have affected the muscles of
             swallowing or the salivary glands

          6. history of chemotherapy or radiation to the head and neck region

          7. severe periodontal disease.

          8. currently pregnant or planning to become pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.
Subject must be at most 99 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Prophylaxis Versus On-demand Therapy Through Economic Report (NCT01159587)

Eligibility criteria:
Inclusion Criteria:

          -  age ≥ 12 years and ≤ 55 years

          -  severe haemophilia A (FVIII < 1%)

          -  absence of inhibitors (Bethesda titre < 0.6 BU/ml)

          -  Previous Treated Patients (prior exposure days > 200)

          -  Kogenate Bayer administered 20-30 IU/kg -3 times a week, for the prophylaxis group

          -  ≥ 6 joint bleeds requiring treatment with FVIII concentrates in the previous 6 months
             before enrollment, for on-demand group

          -  written informed consent

        Exclusion Criteria:

          -  concomitant severe and chronic diseases or congenital skeletal malformation

          -  unreliability of patient or likelihood of follow-up failure

          -  presence of inhibitors or history of inhibitors (in the previous 2 years)

          -  currently on immune tolerance treatment

          -  hepatic cirrhosis or liver disease in rapid progression

          -  AIDS

          -  platelet count < 75,000/mm3

          -  presence of conditions that influence negatively patient´s compliance

          -  participation in another study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Doxycycline for Lateral Epicondylalgia - RCT (NCT00631501)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-65

          -  Pain at the lateral side of the elbow ≥8 weeks

          -  Local tenderness on palpation of the lateral epicondyle

          -  Pain on resisted extension of the wrist

        Exclusion Criteria:

          -  Rheumatic disorder

          -  History of fibromyalgia or generalised pain

          -  Elbow surgery (on the painful side)

          -  Active infection

          -  Glucocorticoid treatment during the duration of symtoms of epicondylalgia

          -  NSAID use within 1 w before presentation and during the study

          -  Pregnancy

          -  Taking drug that might interact with doxycycline
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Creatine for the Treatment of Amyotrophic Lateral Sclerosis (NCT00070993)

Eligibility criteria:
Inclusion Criteria

          -  Diagnosis of probable or definite ALS

          -  At least 5 of 10 testable upper extremity muscle groups (shoulder and elbow
             extensors/flexors and grip) of Medical Research Council (MRC) grade 4 or better

          -  At least 5 years from onset of symptoms

        Exclusion Criteria

          -  Requires tracheostomy ventilation

          -  History of renal disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Gastric Microperfusion in Patients Undergoing Gastroesophageal Resections (NCT02077673)

Eligibility criteria:
Inclusion Criteria:

          -  Patients diagnosed with adenocarcinoma in the gastroesophageal junction

          -  Patients assumed to be resectable

        Exclusion Criteria:

          -  lack of consent

          -  non-adenocarcinomas
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment