araag2/NLI4PR huggingface dataset:
Clinical trial: Description of the Uterine Cavity in Patients With Recurrent Miscarriages (NCT02746588)

Eligibility criteria:
Inclusion Criteria:

          -  Correctly diagnosed with recurrent miscarriages

        Exclusion Criteria:

          -  Known course of the condition
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Entailment
Clinical trial: Botulinum Toxin Injection Versus Anal Myectomy in Management of Idiopathic Constipation (NCT02361749)

Eligibility criteria:
Inclusion Criteria:

          -  Children with Idiopathic constipation

        Exclusion Criteria:

          -  Hirschsprung's disease or Anorectal malformations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Metabolic Syndrome in Children and Adolescents (NCT03203863)

Eligibility criteria:
Inclusion Criteria:

        The study was conducted in children attending 5th and 6th grade in all 20 public schools of
        the Municipality of Puente Alto, Santiago, Chile. All students were invited to participate
        in the study. Parents or their representatives signed an informed consent form and
        boys/girls an informed acceptance form.

        Exclusion Criteria:

        Subjects not signing the informed consent or acceptance forms were excluded from the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 15 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Corneal Nerve Structure in Sjogren's (NCT03203382)

Eligibility criteria:
Inclusion Criteria:

          -  Suspected or confirmed Sjogren's syndrome

          -  18+ years of age

        Exclusion Criteria:

          -  Any condition that in the opinion of the investigator may confound study results or
             cause concerns for safety
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Entailment
Clinical trial: Cardiac Involvement in Patients With Duchenne/Becker Muscular Dystrophy (NCT02470962)

Eligibility criteria:
Inclusion Criteria:

          -  Boys aged 8 to 18 years with DMD/BMD confirmed genetically or by muscle biopsy

          -  Informed consent

        Exclusion Criteria:

          -  Other clinically significant concomitant disease states (e.g., renal failure)

          -  Inability to follow the procedures of the study, e.g. due to language problems,
             psychological disorders, dementia, etc. of the participant or his/her parents or legal
             caregivers,

          -  Inability to lie still for the duration of the imaging procedures (approximately 45
             minutes each for echocardiography and CMR)

          -  MR-incompatible implanted or accidentally incorporated metal device or claustrophobia
             that prohibits use of magnetic resonance imaging
Male
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Single Dose Study in Subjects With Severe Hemophilia A Comparing Pharmacokinetic Parameters for BAY81-8973 and Advate (NCT02483208)

Eligibility criteria:
Inclusion Criteria:

          -  Males, age 18 to 65 years

               -  Subjects with Severe hemophilia A with a documented plasma FVIII level of <1%

               -  ≥ 150 exposure days with FVIII concentrate(s) as supported by medical records

        Exclusion Criteria:

          -  Evidence of current or past inhibitor antibody

               -  History of any congenital or acquired coagulation disorders other than hemophilia
                  A

               -  Platelet count <75,000/mm3

               -  Abnormal renal function (serum creatinine >2 times the upper limit of the normal
                  [ULN] range)

               -  Active liver disease verified by medical history or persistently elevated alanine
                  aminotransferase (ALT) or aspartate aminotransferase (AST) >5 times the ULN or
                  severe liver disease as evidenced by, but not limited to any of the following:
                  International Normalized Ratio (INR) >1.4, hypoalbuminemia, portal vein
                  hypertension including presence of otherwise unexplained splenomegaly and history
                  of esophageal varices.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Biological Clock Dysfunction in Optic Nerve Hypoplasia (NCT00825591)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of ONH (Diagnosis will be confirmed by ocular fundus
             photography.Disc-macula distance 0.35 or below. In eyes without ONH, the DD/DM ratio
             is greater than 0.3581.)

          -  Ages 2-10 years

          -  Ability to ambulate independently

          -  Under care of endocrinologist if on pituitary hormone replacement therapy.

        Exclusion Criteria:

          -  Non-ambulatory

          -  Active malignancy

          -  Cardio-respiratory disorder
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 10 Years

Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? Entailment
Clinical trial: Effectiveness of a Walking Intervention on Impact Loading and Pain (NCT04148807)

Eligibility criteria:
Inclusion Criteria:

        Subjects with a clinical definition of knee OA using NICE guidelines:

          -  Age ≥ 45

          -  Walking related joint pain in the last week that averages ≥ 4 on 11-point numeric
             rating scale, where 0 = no pain and 10 = worst pain possible

          -  History of knee pain for at least 3 months

          -  Morning stiffness in the morning lasting less than 30 minutes

        Exclusion Criteria:

          -  Walk with an assistive device

          -  Current use of oral opiates or centrally acting pain medications

          -  History of lower extremity surgery

          -  Underwent an intra-articular knee joint injection in the past 3 months

          -  Suffer from inflammatory arthritis or other conditions that affect lower extremity
             functions

          -  Currently receiving treatment for their knee and unwilling to stop this treatment for
             the duration of the study

          -  Currently pregnant

          -  Skin allergies to adhesives
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Rehabilitative Trial With tDCS in Amyotrophic Lateral Sclerosis (NCT03293394)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with a diagnosis of probable, laboratory-supported probable, or definite
             amyotrophic lateral sclerosis according to the El Escorial revised criteria

          -  Disease duration ≤ 24 months

          -  Disease progression in the past 3 months

          -  Score ≥ 2 at the item "swallowing" of the ALS Functional Rating Scale Revised

          -  Score ≥ 2 at the item "walking" of the ALS Functional Rating Scale Revised

          -  Treatment with steady regimen of riluzole for a minimum of 1 month before study entry,
             and desiring its continuation

          -  Able to give informed consent

          -  Written informed consent

        Exclusion Criteria:

          -  Motor neuron diseases other than ALS

          -  Severe head trauma in the past

          -  History of seizures

          -  History of ischemic stroke or hemorrhage

          -  Pacemaker

          -  Metal implants in the head/neck region

          -  Severe comorbidity

          -  Intake of illegal drugs

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Low Level Laser Therapy in Knee Osteoarthritis (NCT04682171)

Eligibility criteria:
Inclusion Criteria:

          -  Both males and females

          -  Patients with age 45-65 years

          -  Patients with knee OA of grade II or III according to Kellgren-Lawrence grade.

          -  Pain intensity ranging between> 5 measured by Numeric Pain Rating Scale.

          -  Patients who had minimum score of 25 on the Western Ontario McMaster Universities
             Osteoarthritis Index (WOMAC) total score.

          -  Patients having knee pain for at least 3 months.

        Exclusion Criteria:

          -  Patients with pain in other lower limb joints.

          -  Patients with symptomatic hip osteoarthritis.

          -  Patients with knee surgery in last 6 months.

          -  Patients with complaint of cancer, diabetes, neurological deficit or uncontrolled
             hypertension
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment