araag2/NLI4PR huggingface dataset:
Clinical trial: Efficacy and Safety Study of Human-cl rhFVIII in PTPs With Severe Hemophilia A (NCT01125813)

Eligibility criteria:
Inclusion Criteria:

          -  Severe hemophilia A ((FVIII:C <= 1%)

          -  Male subjects >= 12 years of age

          -  Previously treated with FVIII concentrate, at least 50 EDs

          -  Immunocompetent (CD4+ count > 200/ul)

          -  Negative for anti- HIV; if positive, viral load < 200 particles/u; or <400,000
             copies/mL

        Exclusion Criteria:

          -  Other coagulation disorder than hemophilia A

          -  Present of past FVIII inhibitor activity (.= 0.6 BU)

          -  Severe liver and kidney disease

          -  Receiving of scheduled to receive immuno-modulating drugs
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Single Center Study to Demonstrate the Safety and Performance of Lifelight® First Software Application (NCT03998098)

Eligibility criteria:
Inclusion Criteria:

          1. Subject is informed and has been given ample time and opportunity to think about
             his/her participation and has given his/her written informed consent

          2. Subject is ≥18 years of age

          3. Subject's health status: individual is considered to be healthy (hypertension and
             hypotension is permissible. Other stable diseases at the time of testing are also
             permissible)

          4. Subject is capable of undergoing controlled hypoxaemia to the levels called for the in
             the protocol with minimal medical risk (unless only participating in the blood
             pressure study).

        Exclusion Criteria:

          1. Subject cannot expose their face fully for a reading to be taken

          2. Subject is unable to give informed consent

          3. Subject is outside of the specified age range

          4. Subject has already taken part in the study (all 4 sub studies)

          5. Subject with significant irregular heart rhythm or any disease that might affect the
             results of the study

          6. Subject is not capable of undergoing controlled hypoxia and would be placed at undue
             medical risk if this occurred

          7. Subject has any contraindications identified that would deem them unsuitable to take
             part
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: a Prospective Study on the Efficacy of Magnifying Endoscopy With Narrow-band Imaging in Diagnosing Gastric Lesions (NCT01508520)

Eligibility criteria:
Inclusion Criteria:

          -  patients with gastric lesions which were detected by conventional screening endoscopy
             and suspected of early malignancy.

        Exclusion Criteria:

          -  advanced gastric cancer or any other malignancy;

          -  patients under unsuitable conditions for examination or treatment, such as acute upper
             gastrointestinal bleeding, noncorrectable coagulopathy, severe systemic disease, etc;

          -  inability to provide informed consent;

          -  inability to provide histology of resected specimens after endoscopic treatment or
             surgery.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Seminal Level of Clusterin Before Testicular Sperm Extraction (NCT03857828)

Eligibility criteria:
Inclusion Criteria:

          -  Infertile males , Azoospermia undergoing TESE as a preliminary step for ICSI .

          -  Age: 20-50 year

        Exclusion Criteria:

          -  males <20 years and >50years

          -  Cryptorchidism .

          -  Testicular Agenesis and testicular atrophy .
Male

Subject must be at least 20 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: The Experience of Uncertainty in Parents of Children With an Undiagnosed Medical Condition (NCT00955370)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Men and women 18 years or older

          -  Biological or adoptive parent

          -  At least one child of participants has a medical problem or problems that have
             remained undiagnosed for > 2 years

          -  The child with an undiagnosed medical problem must reside with the parent

          -  Read and write in English

        EXCLUSION CRITERIA:

        -One parent/household may participate
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: 'Wristband Device for the Measurement of Intermittent Blood Pressure and Other Physiological Signals (NCT03409861)

Eligibility criteria:
Inclusion Criteria:

          1. Signed written Institution approved Informed Consent Form (ICF)

          2. Male and Females over the age of 18 years

          3. Patients in intensive care or cardiology units who are under continuous oversight of
             existing Invasive (A-Line) Gold Standard monitors.

          4. Only subjects who are fitted with an invasive Arterial Line (A LINE)

          5. To the extent possible, individuals who have not been using medication 5 (five) hours
             prior to the test shall be classified as non-medicated subjects.

        Exclusion Criteria:

          1. Subject who are unable to provide consent

          2. Where it would be impractical or inconvenient or otherwise unfeasible to place to
             place a wristband and generate a signal.

          3. Subjects who are not fitted with, or not planned to be fitted with an A-Line during
             their stay in the hospital.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Validation of a New Device to Measure Neuromuscular Disease Progression (NCT00606918)

Eligibility criteria:
Inclusion Criteria:

          -  All subjects must be at least 18 years old and able to provide informed consent

          -  All subjects have no health conditions that limit their ability to safely exert
             maximal force using the muscles in their arms and legs.

          -  Subjects with a diagnosis of laboratory supported probable, probable or definite ALS
             according to the World Federation of Neurology El Escorial, as determined by their
             referring neurologist at MGH.

          -  All subjects must be able to speak and understand English.

        Exclusion Criteria:

          -  Presence of significant arthritis, orthopedic conditions, or cardio-pulmonary
             conditions or other medical conditions that may limit the ability to maximally exert
             force safely.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Phase 2 Study of BA058 (Abaloparatide) Transdermal Delivery in Postmenopausal Women With Osteoporosis (NCT01674621)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal woman, less than 85 years old.

          -  BMD T-score ≤-2.5 of spine or hip (femoral neck) or ≤-2.0 with previous fracture
             (within 5 years).

          -  Normal physical exam, vital signs, electrocardiogram (ECG), and medical history.

          -  Laboratory tests within the normal range, including serum calcium, Vitamin D,
             parathyroid hormone (PTH) (1-84), serum phosphorus, and alkaline phosphatase.

        Exclusion Criteria:

          -  BMD T-score ≤-5.0 at the lumbar spine or hip.

          -  History of bone disorders (for example, Paget's disease) other than postmenopausal
             osteoporosis.

          -  Significantly impaired renal function.

          -  History of any cancer.
Female
No healthy subjects accepted to join the trial.

Subject must be at most 85 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Vital Signs Patch Early Feasibility and Usability Study v1.0 (NCT02524470)

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female in-patients with vital signs considered 'stable' by clinical
             caregivers.

        Exclusion Criteria:

          -  Pediatric patients

          -  Female patients who are pregnant

          -  Patients with internal or external defibrillators

          -  Patients who have undergone surgery and still have a fresh incision on the chest.

          -  Patients with skin damage on the chest such as burns, irritation, infections, wounds,
             etc.

          -  Patients in the Critical Care Unit (CCU)

          -  Patients who otherwise satisfy any of the contraindications associated with the VSP
             system.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Study on Combined Use of Letrozole, Mifepristone and Misoprostol in Termination of Pregnancy (NCT01475318)

Eligibility criteria:
Inclusion Criteria:

          -  good general health

          -  older than the age of legal consent (i.e. >18 years old)

          -  requesting medical abortion and eligible for abortion

          -  on Day 1 of the study (day of letrozole and mifepristone administration) the duration
             of pregnancy not more than 63 days as confirmed by pelvic ultrasound examination

          -  intrauterine pregnancy (intrauterine amniotic sac seen in US)

          -  willing to use other than hormonal or intra-uterine contraception until the first
             menses after termination of pregnancy

          -  if treatment should fail agrees to termination of pregnancy with the surgical method

          -  willing and able to participate after the study has been explained

          -  haemoglobin higher than 10g/L, normal liver and renal function

        Exclusion Criteria:

          -  a history or evidence of adrenal pathology, steroid-dependent cancer, porphyria,
             diastolic pressure over 95mm Hg, bronchial asthma, arterial hypotension

          -  a history or evidence of thrombo-embolism, severe or recurrent liver disease or
             pruritus of pregnancy

          -  the regular use of prescription drugs before admission to the study

          -  the presence of an IUCD in utero

          -  breast-feeding

          -  multiple pregnancies

          -  heavy smoker of more than 20 cigarettes per day

          -  any abnormal values in pre-treatment blood tests
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction