araag2/NLI4PR huggingface dataset:
Clinical trial: Regression of Hamstring Flexibility and Performance in Children With Duchenne Muscular Dystrophy (NCT03589612)

Eligibility criteria:
Inclusion Criteria:

          -  To be a Duchenne Muscular Dystrophy diagnosis,

          -  Being in the ambulatory period and climbing four steps independently,

          -  to be Level 1 and Level 2 according to Brooke Lower Functional Classification Test

          -  To be able to cooperate

          -  No any severe contracture in the lower limbs which may prevent assessments,

        Exclusion Criteria:

          -  Children who fail to meet these criteria study.
Male

Subject must be at least 5 Years old.
Subject must be at most 14 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton Disease (NCT02473029)

Eligibility criteria:
Inclusion Criteria:

          -  Patients admitted to the Fondation Ophtalmologique Adolphe de Rothschild and suspected
             to suffer from Horton disease, based on the presence of 3 or more major criteria, or 2
             major criteria and at least one minor criteria.

        Major criteria : Age > 50 ans ; headache ; intermittent jaw or tongue pain ; visual
        impairment ; ESR > 50 mm at 1h and/or CRP > 8mg/l.

        Minor criteria: temporal artery or scalp tenderness ; facial pain or tenderness ; fever
        >38°C, weight loss >10%, anorexia, fatigue.

        Exclusion Criteria:

          -  Autoimmune disease

          -  Active infectious condition

          -  Malignant disease

          -  Condition counterindicating one or several of the protocol's imaging procedures :
             allergy to iodine and/or renal insufficiency and/or claustrophobia and/or metallic
             foreign body...
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: Development and Needs Assessment and Efficiency of Smart Communication System for Patients With ALS (Part 1) (NCT03806647)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of ALS

          -  Taiwanese and used traditional Chinese(Mandarin).

          -  If they were older than age 20 years.

        Exclusion Criteria:

          -  Frontotemporal dementia, severe depression, or schizophrenia.

          -  If they cannot complete the questionnaire with researchers or family members help.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Treatment of Inherited Factor VII Deficiency (NCT01269138)

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent by the patient or next of kin or legally acceptable
             representative to collect data on treatment of a given bleeding episode, surgical
             event or prophylactic regimen as specified in the protocol.

          -  If informed consent is provided by the next of kin or legally acceptable
             representative, consent must also be obtained from the patient as soon as he/she is
             able to do so.Informed consent should preferentially be obtained before initiation of
             treatment or as a minimum before entry of data into the database. 2.Males and females
             0 to 90 years of age. 3. Any patient with a FVII deficiency for whom treatment of
             bleeding episodes, prevention related to surgery and primary/secondary prophylaxis is
             considered necessary by the treating physician can be enrolled.

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 90 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Improved Muscle Function in Duchenne Muscular Dystrophy Through L-Arginine and Metformin (NCT02516085)

Eligibility criteria:
Inclusion Criteria:

          -  Molecular diagnosis of DMD

          -  Patients 7 - 10 years of age at time of screening

          -  Ambulant

        Exclusion Criteria:

          -  Previous (3 months or less) or concomitant participation in another therapeutic trial

          -  Use of L-arginine, L-citrulline or metformin within the last 3 months

          -  Known individual hypersensitivity to L-citrulline or metformin

          -  Other chronic disease or clinical relevant limitation of renal, liver, heart function
             according to discretion of the investigator
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.
Subject must be at most 10 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males (NCT03541395)

Eligibility criteria:
Inclusion Criteria:

        healthy males

        Exclusion Criteria:

        use of anabolic steroids, use of narcotics,
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 30 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effects of Chronic Ozone Exposure on Lung Function (NCT00006306)

Eligibility criteria:
No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 21 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Safety and Efficacy Study of Ispronicline (TC-1734-112) in Subjects With Age Associated Memory Impairment (AAMI) (NCT00109564)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female subjects aged 50-80 years.

          -  Lives with a significant other.

          -  Has subjective memory complaints. Verbal verification of this subjective memory
             complaint will be obtained from the significant other.

          -  Has no severe, uncontrolled medical condition.

          -  If receiving treatment for a medical condition, that treatment has been stable for at
             least 2 months before entering the trial and to remain stable throughout the trial.

        Exclusion Criteria

          -  Aged less than 50 years or greater than 80 years.

          -  Lives alone.

          -  Has any medical condition not adequately controlled, or likely to interfere with
             performance of the study procedures.

          -  Medication for a medical condition has been changed in the last 2 months or during the
             trial.

          -  Administration of acetylcholinesterase inhibitors and gingko biloba within 2 months
             prior to entering the study.

          -  Has evidence of depression or anxiety

          -  Meets DSM-IV criteria for Alzheimer's or vascular dementia.

          -  Has participated in an investigational drug trial in the previous 30 days.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Treatment of Newly Diagnosed Gastroesophageal Reflux Disease in a National Population-based Cohort (NCT03524781)

Eligibility criteria:
Inclusion Criteria:

          -  Danish adult patient with GERD-diagnosis verified by upper endoscopy 1997-2014

        Exclusion Criteria:

          -  Any diagnosis of cancer in the gastrointestinal tract during follow-up

          -  Patients with GERD-diagnosis within previous four years or with concomitant diagnosis
             requiring independent anti-secretory treatment will be excluded (DK25.0-9, DK26.0-9,
             DK27.0-9, DK22.7 & DE16.4B).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: A Comparison of Two Treatments: Pacemaker and Percutaneous Transluminal Septal Ablation for Hypertrophic Cardiomyopathy (NCT00001894)

Eligibility criteria:
Patients of either gender, aged 18-80 years.

        NYHA functional class III/IV, or syncope, or greater than or equal to 2 presyncope despite
        verapamil and/or Beta-blocker therapy.

        LV outflow tract gradient greater than or equal to 30 mm Hg at rest or greater than or
        equal to 50 mm Hg following isoproterenol infusion to a heart rate of greater than 100 bpm.

        No patients with mid-cavity obstructive HCM.

        No patients with LV septal wall thickness less than 15 mm estimated by echocardiography.

        No patients with greater than 50 percent luminal narrowing in a major coronary artery
        vessel.

        No patients with chronic atrial fibrillation.

        No patients with a positive pregnancy test.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment