araag2/NLI4PR huggingface dataset:
Clinical trial: Metformin in Overweight Type 2 Diabetes Mellitus (NCT00922194)

Eligibility criteria:
Inclusion Criteria:

          -  Type 2 Diabetes Mellitus

          -  BMI more than 25

        Exclusion Criteria:

          -  Type 1 diabetes

          -  pancreatic diabetes

          -  presence of concomitant endocrinal disorder

          -  non-overweight type 2 diabetes

          -  type 2 diabetes with secondary failure to sulfonylurea and taking insulin

          -  presence of proliferative retinopathy or chronic renal failure

          -  known cirrhosis of liver

          -  heavy alcoholic

          -  presence of active tuberculosis

          -  known HIV disease or any active infection

          -  major mental illness

          -  failure to comply with the exercise advice due to physical incapacity (e.g., severe
             osteoarthritis, hemiparesis or any other disabling neurological disease)

          -  present pregnancy (or planning pregnancy)

          -  lactating mothers

          -  using any kind of hormones including oral contraceptives, systemic corticosteroids,
             nicotinic acid

          -  use of anti-obesity drug within the past 3 months

          -  chronic gastroparesis or chronic severe gastrointestinal symptoms

          -  a history of gastric or duodenal ulcers

          -  abdominal surgery within 1 year will not be included in the study

          -  patients with congestive heart failure or overt nephropathy will also not be included,
             due to unreliability of anthropometric measurements in such subjects and the relative
             risk of lactic acidosis
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Your Voice; Impact of Duchenne Muscular Dystrophy (DMD) on the Lives of Families (NCT03680365)

Eligibility criteria:
Inclusion Criteria:

          1. Participant must be a person with DMD who is 11 years or older or The parent/legal
             guardian of a person with DMD who is under the age of 18 years.

          2. Confirmed diagnosis of DMD with written proof of disease provided

          3. Resident of the U.S.

          4. Able to read, write and communicate in English

          5. Able to grant informed consent

          6. Willing to participate in a 45 minute telephone interview

          7. Ability to view or receive a document from the interviewer before or during the
             interview (web browser, ability to receive a text, fax or document by mail)

        Exclusion Criteria:

        1. Inability to meet any of the inclusion criteria
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 11 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Role of Dienogest in the Treatment of Patient With Symptomatic Adenomyosis (NCT03654144)

Eligibility criteria:
Inclusion Criteria:

          -  symptomatic adenomyosis

          -  irregular menstrual bleeding and dysmenorrhea .

        Exclusion Criteria:

          -  asymptomatic patients -

          -  non-lactating patient

          -  not desire for pregnancy

          -  no hormonal treatment more than 6 month even contraception e.g IUD

          -  no focal lesion of uterus (malignancy ,fibroid or adenxal mass )
Female
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Micro RNAs as a Marker of Aortic Aneurysm in Hereditary Aortopathy Syndromes (NCT02213484)

Eligibility criteria:
Inclusion Criteria: To be in the study, the participant must meet the following criteria

          1. Diagnosis of hereditary aortopathy based upon:

               -  Confirmation of a disease causing mutation in a known aortopathy disorder OR

               -  Confirmation of disease based on published clinical criteria

          2. Participants is male or female and greater than 30 days old

          3. Participants are able to undergo standard of care cardiac monitoring including an
             echocardiogram

          4. Willing and able to provide written informed consent by parent(s) or guardian(s) after
             the nature of the study has been explained and prior to any research related
             procedures

          5. Signed HIPPA compliant research authorization

        Exclusion Criteria: Participant will be excluded from the study for any of the following
        criteria

          1. Diagnosis of a hereditary aortopathy can not be confirmed

          2. Existence of an additional comorbid condition- including a co-existing genetic
             syndrome, heart failure, renal disease, rheumatologic disease, history of malignancy,
             thyroid disease, recent stroke, other life-limiting illness not related to
             cardiovascular disease.

          3. Extreme prematurity, <28 weeks gestational age
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers

Subject must be at most 60 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? Entailment
Clinical trial: Treating Tinnitus Using Eutectic Mixture of Local Anesthetics (EMLA) 5% Cream (NCT02266160)

Eligibility criteria:
Inclusion Criteria:

          -  mature (above 18 years old) patients that suffer tinnitus (unilateral/bilateral) with
             sensorineural hearing loss

        Exclusion Criteria:

          -  patients that are treated for tinnitus( psychological treatment, hearing aid)

          -  drugs that affect the CNS

          -  sensitivity to amide anaesthetic

          -  hepatic failure

          -  usage of antiarrhythmic drugs

          -  severe depression any patients that develops during the trial local/ systemic symptoms
             such as rash, pain, itching, fever, nervousness,palpitations will be omitted from the
             study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment
Clinical trial: Effect of Curcumin on Iron Metabolism in Healthy Volunteer (NCT01489592)

Eligibility criteria:
Inclusion Criteria:

          -  Body mass index between 18 et 25 Kg/m²

          -  Non smoker

          -  No swallowing disorders

          -  Normal clinical exam

          -  Normal ECG

          -  Normal values for routine biological tests : serum iron, transferrin saturation,,
             hemogram ferritin, C Reactive Protein, AST, ALT, HDL and LDL cholesterol,
             triglycerides

          -  No C282Y mutation within the HFE gene

          -  Affiliation to social security

          -  Written informed consent obtained

        Exclusion Criteria:

          -  Chronic or evolutive disease

          -  Infection during the 7 days before each sequence

          -  Drug or alcohol (>30g) abuse

          -  Current treatment

          -  Known food allergy

          -  stay at altitude (> 1500m) in 2 months

          -  Positive serology for hepatitis B or C virus or HIV.

          -  Transfusion or blood donation during the last three months.

          -  Exclusion period on the healthy volunteer National File.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effectiveness of Cane in Osteoarthritis (OA) Patients (NCT00698412)

Eligibility criteria:
Inclusion Criteria:

          -  Primary Knee osteoarthritis (ACR criteria)

          -  VAS for knee pain between 3 and 7

          -  No changes the NSAID intake or physical activity in the previous 3 months

        Exclusion Criteria:

          -  Symptomatic heart or pulmonary disease

          -  Severe systemic disease

          -  Other symptomatic disease in the lower limb or in the upper limb that will carry the
             cane

          -  Joint injection in the previous 3 months

          -  PT in the previous 3 months

          -  Previously cane use

          -  Start regular physical activity in the last month
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of Gastrostomy on Amyotrophic Lateral Sclerosis (NCT00337402)

Eligibility criteria:
Inclusion Criteria:

          -  patients > 18 years-old

          -  ALS certain or probable

          -  vital capacity (respiratory) > 70 %

          -  under riluzole

        Exclusion Criteria:

          -  ALS in family

          -  other conditions affected survival and QoL

          -  cognitive impairment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Selective Neurectomy and Mesh Removal for Chronic Postherniotomy Pain (NCT00627289)

Eligibility criteria:
Inclusion Criteria:

          -  Adult ( more than 18 years old) patients with chronic pain after groin hernia surgery,
             and pain related impairment of everyday function. The pain should have occurred after
             previous open surgery.

          -  The patient should be able to locate to a specific area with maximum pain. Patients
             should be able to understand and use pain scales, and the AAS-scale.

        Exclusion Criteria:

          -  All that contradicts the above
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Transversus Abdominis Plane Block and Inguinal Hernia Repair (NCT02030223)

Eligibility criteria:
Inclusion Criteria:

        ASA I-III patients undergoing inguinal hernia repair with a mesh

        age between 18 and 75 years old

        ability to read and write greek

        -

        Exclusion Criteria:

          -  Inability to consent to the study

          -  BMI >40kg/m2

          -  Skin infection at the puncture site

          -  Contraindication to mono-amide local anaesthetics, paracetamol, NSAID's (parecoxib)

          -  Preoperative use of opioids or NSAID's for chronic pain conditions
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment