araag2/NLI4PR huggingface dataset:
Clinical trial: Sex Hormones & Serum Sclerostin Level (NCT01418924)

Eligibility criteria:
Inclusion Criteria:

          -  premenopausal women

          -  healthy

          -  volunteer

        Exclusion Criteria:

          -  Endocrinopathies

          -  Bone disease (osteoporosis, osteomalacia, paget disease etc)

          -  Women who used hormonal drug within last six months

          -  Cognitive disorders
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: CAVA: Dizziness Trial (NCT04026516)

Eligibility criteria:
Inclusion Criteria:

        Adults aged 18 and over.

          -  Patients experiencing episodes of true vertigo, with at least two episodes within the
             preceding month. Relevant medical conditions include Meniere's disease, Benign
             Paroxysmal Positional Vertigo (BPPV), recurrent vestibulopathy and vestibular
             migraine.

          -  Able to commit to 30 days of continuous wear of the trial device as per the study
             plan.

          -  Own a telephone.

        Exclusion Criteria:

          -  Potential participants who have a history of dermatological disease, fragile skin, or
             damage around the forehead.

          -  Potential participants who have an allergy to plasters and/or medical adhesives -
             (similarly to materials used in the device).

          -  History of hypertension or cardiac problems (uncontrolled, acute or de-compensated -
             phase).

          -  History of ear disease, or previous ear surgery.

          -  History of psychotic/neurotic disorders or epilepsy.

          -  History of eye disease, or previous eye surgery.

          -  Pregnant or nursing mothers.

          -  Potential participants who have taken part in a previous CAVA trial.

          -  Potential participants who are currently taking part in another trial.

          -  Unable to follow the testing protocol.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment
Clinical trial: Vasculitis Illness Perception (VIP) Study (NCT02190916)

Eligibility criteria:
Inclusion Criteria:

          -  Enrolled in VCRC Contact Registry

          -  Patient reported diagnosis of granulomatosis with polyangiitis (Wegener's
             granulomatosis), Microscopic Polyangiitis, Churg-Strauss Syndrome, Polyarteritis
             Nodosa, Giant Cell Arteritis, Takayasu's Arteritis, Henoch-Schöenlein Purpura, Behçets
             disease, and CNS Vasculitis

          -  18 years of age or older

          -  English speaking

        Exclusion Criteria:

          -  Inability to provide informed consent and complete survey
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? Entailment
Clinical trial: Validity and Reliability of Smartphone Use in Measuring Joint Position Sense in Patients With Knee Osteoarthritis (NCT03658915)

Eligibility criteria:
Inclusion Criteria:

          -  Patient must be referred to the outpatient clinic of the faculty of Physical Therapy
             and Medicine, Cairo University with a confirmed diagnosis of unilateral or bilateral
             osteoarthritis of the knee and having one or more of the following criteria (ASo,
             2000).

          -  Morning stiffness for less than 30 minutes.

          -  Crepitus on active knee movement.

          -  Bony enlargement either palpable or visible in radiographs.

          -  Bony tenderness at joint margins.

          -  Age 40-60 years old.

        Exclusion Criteria:

          -  Steroid injection within 2 months prior to inclusion.

          -  Presence of neurologic disorders (e.g., stroke, Parkinson's disease, or
             poliomyelitis). •Presence of other rheumatoid or orthopedic disorders in the lower
             extremity or spine. •A recent history of a lower extremity fracture with in the past
             year.

          -  History of ligament deficiency, such as anterior cruciate ligament or meniscal injury.

          -  Severe pain with active movement.

          -  Poor memory or cognitive function.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Contradiction
Clinical trial: Pathophysiological Effects of Intrapleural Pressure Changes During Therapeutic Thoracentesis (NCT02192138)

Eligibility criteria:
Inclusion Criteria:

          1. age 18 - 85 years,

          2. pleural effusion occupying more than one third of the hemithorax on the
             posteroanterior chest radiograph,

          3. therapeutic thoracentesis planned on the basis of signs and symptoms as well as
             imaging and functional studies,

          4. no contraindications for thoracentesis,

          5. signed informed consent for participation in the study.

        Exclusion Criteria:

          1. poor performance status requiring maximal shortening of the procedure,

          2. instable hemodynamic or respiratory status unrelated to pleural effusion,

          3. respiratory failure requiring mechanical ventilation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Proof of Concept Study Efficacy of an Antacid/Lansoprazole Combination for Relief of Heartburn (NCT01037452)

Eligibility criteria:
Inclusion Criteria:

          -  Experiencing heartburn in the past month if untreated

          -  Having heartburn that responds to heartburn medication

          -  Be willing to discontinue the use of heartburn treatment for 7 days prior to inclusion
             in the study.

        Exclusion Criteria:

          -  Having history of erosive esophagitis or gastroesophageal reflux disease (GERD)
             diagnosed by a physician and confirmed by testing (endoscopy)

          -  Be unwilling to take only the study medication, and antacid provided as a rescue
             medication for relief of acute heartburn during the study.

        "Other protocol-defined inclusion/exclusion criteria may apply"
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux Disease (NCT00260572)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with reflux symptoms present for at least 6 months, caused by documented
             reflux. Reflux symptoms include:

               -  heartburn

               -  acid regurgitation

               -  waterbrash

               -  non-cardiac chest pain

               -  dyspepsia

          -  Reflux diagnosis either by endoscopy, upper gastrointestinal (GI), or 24 hour pH.

          -  Patients scheduled for surgical management of GERD and/or hiatal hernia

          -  Patients currently or commencing treatment with at least proton pump inhibitors or
             pro-motility agents.

        Exclusion Criteria:

          -  Patients unable to comprehend or complete the QOL instruments.

          -  Patients less than 18 years of age.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: ACTH vs Betamethasone in Hospitalized Patients With Acute Gout (NCT04306653)

Eligibility criteria:
Inclusion Criteria:

          1. Age>18 years

          2. able to provide written informed consent

          3. diagnosis of acute gout according to ACR/EULAR classification criteria -

        Exclusion Criteria:

          1. pregnancy/lactation

          2. unable to provide written informed consent -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Lauren Classifications and HER2 Status in Gastric Cancer Patients (NCT01927146)

Eligibility criteria:
Inclusion Criteria:

          1. Patients' admission date: 1996-2006.

          2. Histologically confirmed gastric adenocarcinoma patients and underwent gastrectomy.

          3. Adequate paraffin- embedded tumor tissue sample for pathologic and human epidermal
             growth factor receptor 2 (HER2) status analysis.

          4. Integrity medical records with regular survival follow up, the overall survival (OS)
             could be sourced.

        Exclusion Criteria:

          1. Age<18 years old.

          2. Other malignancy within the last 5 years, except for carcinoma in situ of the cervix,
             or basal cell carcinoma.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Intrauterine Injection of Human Chorionic Gonadotropin Injection (hCG) Before Embryo Transfer on Pregnancy Outcomes in Frozen Embryo Transfer Cycles. (NCT02825108)

Eligibility criteria:
Inclusion Criteria:

          1. Patients with history of one fresh embryo transfer failure

          2. Patients with Primary infertility

          3. Patients with at least one embryo with excellent quality

        Exclusion Criteria:

          1. Female age over 40 years old

          2. Severe male factor (Azoospermia)

          3. Endometriosis diagnosis and the presence of hydrosalpinges

          4. Uterine factor ( polyps, myoma and previous myomectomy, …)

          5. Patients with polycystic ovarian syndrome diagnosis

          6. Cases with pre-implantation genetic diagnosis (PGD)indication

          7. Cases with difficult embryo transfer or use of Tenaculum

          8. Patients with repeated implantation failures and repeated miscarriages.

          9. Female smokers
Female
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction