araag2/NLI4PR huggingface dataset:
Clinical trial: AP-004-A Randomized, Controlled Study to Evaluate Efficacy and Safety of Intra-articular Ampion for Osteoarthritis Pain in Knee (NCT02024529)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis and radiological evidence of symptomatic osteoarthritis of the knee

          -  Moderate to severe pain

        Exclusion Criteria:

          -  Other conditions in the knee, e.g., crystal arthropathies, septic necrosis, joint
             replacement, major injury within 12 months prior to screening, tense effusions

          -  Requires ongoing treatment with intra-articular pain medications or systemic
             corticosteroids
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Melatonin Osteoporosis Prevention Study (NCT01152580)

Eligibility criteria:
Inclusion Criteria:

          -  Inclusion criteria include perimenopausal women,

          -  willingness to participate in the 6-month study, willingness to undergo testing of
             bone turnover markers before and after the drug therapies and willingness to provide a
             self-assessment on quality of life and sleep throughout the program.

          -  Subjects must be willing to take their treatments right before bed and to not to
             consume alcohol with this medication.

        Exclusion Criteria:

          -  Exclusion criteria will include women in whom osteopenia is a result of some other
             known process such as hyperparathyroidism, metastatic bone disease, multiple myeloma
             or chronic steroid use.

          -  Those individuals on osteoporotic drugs, hypnotics, CYP1A2 inhibiting drugs,
             fluvoxamine or those with severe sleep apnea, severe COPD and those with moderate or
             severe hepatic impairment will also be excluded.

          -  Individuals who are lactose intolerant will also be excluded because the placebo and
             melatonin capsules will contain lactose.
Female
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 54 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Determinants of Respiratory Health in Young Adults (NCT00005361)

Eligibility criteria:
No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Hypertension Intervention Nurse Telemedicine Study (HINTS) (NCT00237692)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of uncontrolled hypertension,

          -  prescribed a medication to lower blood pressure,

          -  have a regular primary care physician at Durham VA Medical Center, and

          -  be a veteran. For Sustainability portion the patient must have participated in an
             intervention arm of primary study.

        Exclusion Criteria:

          -  Hospitalized in past 3 months for stroke,

          -  heart attack,

          -  surgery for blocked arteries,

          -  diagnosed with metastatic cancer or treated with dialysis,

          -  have a diagnosis of dementia or a hearing impairment which prevents them from being
             able to hear/speak on the telephone, and

          -  creatinine serum lab which exceed 2.5.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Efficacy of Neiguan (P6 Point) Acupressure in Patients With Gastroesophageal Reflux Disease (GERD) (NCT02255071)

Eligibility criteria:
Inclusion Criteria:

          1. Male or female

          2. Age of 20-60 years

          3. Suffered from heartburn with or without acid regurgitation

        Exclusion Criteria:

          1. Suffered from peptic ulcer, gallstones, cancer, and Barrett's esophagus

          2. previously underwent the esophagus, stomach or duodenum surgery

          3. Lactating women or pregnant women

          4. patients with severe cardiovascular disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Pretreatment With Norethindrone Acetate Prior to Levonorgestrel IUS Insertion for Heavy Menstrual Bleeding (NCT01391052)

Eligibility criteria:
Inclusion Criteria:

          -  You must be between 18-45 years old

          -  You have Heavy Periods

        Exclusion Criteria:

          -  You are pregnant

          -  You are currently using hormonal contraception or hormonal therapy

          -  You have a history of pelvic inflammatory disease (and have not had a normal pregnancy
             since)

          -  You had an infected abortion within the last three months

          -  You have abnormal or cancerous cells of the cervix or uterus

          -  You have an actine infection in your genital organs

          -  Known or suspected breast cancer

          -  Active liver disease or tumors

          -  Allergy to levonorgestrel or norethindrone

          -  You currently have deep vein thrombosis, pulmonary embolism, or history of these
             conditions

          -  you currently have active or recent (within the past year) arterial thromboembolic
             disease (such as a stroke or myocardial infarction) these conditions
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Study to Test the Safety of an Investigational Drug Given Repeatedly to Adult Men With Severe Hemophilia (NCT03996486)

Eligibility criteria:
Inclusion Criteria:

          -  Participants with hemophilia A and FVIII activity <1% or hemophilia B with FIX
             activity <2%

          -  Participants must be currently without inhibitors or with low titer inhibitors
             (inhibitor titer < 5 Bethesda units) who are receiving current on demand treatment
             with any FVIII or FIX (recombinant or plasma-derived; modified or unmodified)

        Exclusion Criteria:

          -  History or at risk of developing diseases related to venous thromboembolic events
             (e.g., pulmonary embolism, deep vein thrombosis or thrombophlebitis)

          -  History of any other clinically relevant coagulation disorder (particularly
             disseminated intravascular coagulopathy or combined FVIII/Factor V deficiency) or
             platelet disorder

          -  History or at risk of developing cardiac, coronary and/or arterial peripheral
             atherosclerotic disease and/or arterial thromboembolic events, particularly myocardial
             infarction, cerebrovascular accident, stroke, transient ischemic attack, congestive
             heart failure, angina pectoris, treatment for angina pectoris or uncontrolled
             hypertension

          -  History or at risk for thrombotic microangiopathy
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study Evaluating the Effect of Etoricoxib and Indomethacin in the Treatment of Acute Gout (0663-081)(COMPLETED) (NCT00142558)

Eligibility criteria:
Inclusion Criteria:

          -  Males or females at least 18 years of age who have acute gout.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Entailment
Clinical trial: Idiopathic Pulmonary Fibrosis--Pathogenesis and Staging - SCOR in Occupational and Immunological Lung Diseases (NCT00005317)

Eligibility criteria:
No eligibility criteria
Male
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Entailment
Clinical trial: Metformin in Children and Adults With Fragile X Syndrome (NCT03722290)

Eligibility criteria:
Inclusion Criteria:

          -  Aged between 10 et 45 years old

          -  BMI > 18.3

          -  Molecular diagnosis of FXS

          -  Accompanied by his legal tutor

        Exclusion Criteria:

          -  Pregnancy/Breastfeeding

          -  Intolerance to metformin

          -  History of lactic acidosis

          -  Gastric/renal/hepatic pathology

          -  Acute medical condition

          -  Concomitant use of ACE inhibitors

          -  Modification of antipsychotic treatments in the last 6 weeks
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment