araag2/NLI4PR huggingface dataset:
Clinical trial: A Multi-Center Controlled Screening Trial of Safety and Efficacy of Lithium Carbonate in Subjects With Amyotrophic Lateral Sclerosis (ALS) (NCT00790582)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of laboratory-supported probable, probable, or definite ALS

          -  Vital capacity of at least 75% of predicted

          -  Onset of weakness within 3 years prior to enrollment

          -  If patients are on riluzole, they must be on a stable dose for at least 30 days prior
             to baseline visit

          -  Women of childbearing potential must be surgically sterile or using an effective
             method of birth control and have a negative pregnancy test

          -  Willing and able to give informed consent

        Exclusion Criteria:

          -  Diagnosis of other neurodegenerative disease

          -  Need tracheotomy ventilation or non-invasive ventilation 23 or more hours/day

          -  Clinically significant history of any unstable medical condition in past 30 days

          -  History of renal

          -  History of liver disease

          -  Current pregnancy or lactation

          -  Use of lithium within thirty days of enrollment

          -  Significantly limited mental capacity

          -  History of recent drug or alcohol abuse

          -  Use of any investigational drug within 30 days prior to enrollment
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Levonorgestrel Contraceptive Intrauterine Systems (LCS) Pearl Index Study (NCT00528112)

Eligibility criteria:
Inclusion Criteria:

          -  Age between 18 and 35 years (inclusive), in good general health and requesting
             contraception.

          -  Has regular menstrual cycles (length of cycle 21-35 days) (i.e., endogenous cyclicity
             without hormonal contraceptive use).

        Exclusion Criteria:

          -  Known or suspected pregnancy or is lactating.

          -  History of ectopic pregnancies.

          -  Any genital infection (until successfully treated).

          -  Abnormal uterine bleeding of unknown origin.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Phased-Implementation Feasibility and Proof-of-Concept Study to Assess Incorporating the NIDA CTN Common Data Elements (CDEs) Into the Electronic Health Record (EHR) in Large Primary Care Settings ("CDE-EHR-PC" Study), Phase 1 (NCT02974335)

Eligibility criteria:
Inclusion Criteria:

          -  Must be a current primary care clinic patient

        Exclusion Criteria:

          -  Inability to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluation of Momentary Affect Regulation - Safer Sex Intervention (NCT04798248)

Eligibility criteria:
Inclusion Criteria:

          -  Be an active patient of one of the participating Planned Parenthood health centers

          -  Own a smartphone

          -  Be fluent in English

          -  Be 17 to 20 years of age

          -  Be biologically able to become pregnant (to the best of their knowledge)

          -  Score at least 10 on the PHQ-8

          -  Have had penile-vaginal sex in the past 3 months

          -  Have had penile-vaginal sex at least once a week, on average

          -  Report having done at least one of the following during the 3 months preceding
             eligibility screening: 1) Not using a condom every time they have sexual intercourse;
             2) Used condoms, a diaphragm, cervical cap, spermicide, sponge, fertility awareness,
             or withdrawal as a primary form of birth control; 3) Had sexual intercourse with more
             than one person; 4) Had sexual intercourse within 2 hours after using drugs and
             alcohol; and/or 5) Been treated for an STI/STD

        Exclusion Criteria:

          -  Trying to get pregnant or currently pregnant at the time of eligibility screening

          -  Have given birth during the 6 months preceding eligibility screening

          -  Married or engaged to be married at the time of eligibility screening
Female
No healthy subjects accepted to join the trial.
Subject must be at least 17 Years old.
Subject must be at most 20 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Assessment of Novel Sound Changing Principles in Hearing Instruments to Determine Their Application - 2020_09 (NCT04578457)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy outer ear (without previous surgical procedures)

          -  Ability to fill in a questionnaire conscientiously

          -  Informed Consent as documented by signature

          -  Minimum 1 year hearing aid experience

          -  Moderate-Severe (N3-N5) hearing loss or Normal Hearing

        Exclusion Criteria:

          -  Contraindications to the MD in this study, e.g. known hypersensitivity or allergy to
             the investigational product

          -  Limited mobility and not in the position to attend weekly appointments

          -  Inability to produce a reliable hearing test result

          -  Massively limited dexterity

          -  Known psychological problems

          -  Known central hearing disorders
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: COVID-19, Aging, and Cardiometabolic Risk Factors Study (NCT04802044)

Eligibility criteria:
Inclusion Criteria:

          -  Patients newly diagnosed with COVID-19 at hospital setting or community screening,
             confirmed with biological proof (RT-PCR)

        Exclusion Criteria:

          -  Subjects opposed to the use of their data

          -  Minors, adults under guardianship, protected persons

          -  History of malignancy

          -  History of autoimmune disease

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Controlled Study of ONO-5920 in Patients With Involutional Osteoporosis in Japan (NCT00212719)

Eligibility criteria:
Inclusion Criteria:

          1. A diagnosis in accordance with Criteria for the Diagnosis of Primary Osteoporosis.

          2. Other inclusion criteria as specified in the study protocol.

        Exclusion Criteria:

          1. Patients having secondary osteoporosis or another condition that presents low bone
             mass.

          2. Patients having findings that affect measurement of lumbar spinal bone mineral density
             by DXA

          3. Patients that have been administered bisphosphonate derivatives.

          4. Other exclusion criteria as specified in the study protocol.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Menstrual Cycle-induced Pain, Fatigue and Anxiety in Women Suffered From COVID-19 (NCT04806815)

Eligibility criteria:
Inclusion Criteria:

          -  Being between the ages of 18 and 45,

          -  PCR test result positive confirmed having COVID-19 infection,

          -  Women had at least one period of Menstrual cycle after COVID-19

          -  Being an Internet connection,

          -  To be able to speak and write in Turkish.

        Exclusion Criteria:

          -  To be in the premenaposual/postmenopausal period (to be in the transition period to
             menopause or in the period after menopause.)

          -  Having insufficient co-operation.
Female

Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Decision Support System Algorithm for COVID-19 Diagnosis (NCT04479319)

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients with a differential diagnosis of COVID-19

        Exclusion Criteria:

          -  Patients who are under 18 year-old

          -  Patients who have not either Thorax CT or SARS-CoV-2 RT-PCR
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Clinical and Immunological Evaluation of Children With Allergies (NCT00102570)

Eligibility criteria:
-  INCLUSION CRITERIA:

        Males and females, age 3 months to 19 years old, (less than 18 years old).

        Individuals referred to the NIH with a diagnosis of asthma, rhinitis, anaphylaxis,
        urticaria, atopic dermatitis, food allergy, stinging insect allergy or other
        allergic/inflammatory diseases.

        Subjects must maintain a primary physician for protocol related and non-related long-term
        follow-up and for any emergency medical treatment required.

        INCLUSION CRITERIA FOR PARENTS:

        Must be biological Parent

        Must have a child with a diagnosis of allergic disease

        EXCLUSION CRITERIA:

        Inability to provide informed consent or assent. In the case of minors, unavailability of a
        parent or guardian.

        EXCLUSION CRITERIA FOR PARENTS:

        Non-biological parent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Months old.
Subject must be at most 19 Years

Patient description (medical language): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient description (patient's own words): I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Does the patient match the trial criteria? Entailment
Clinical trial: Metabolomics During Testosterone Therapy (NCT01963390)

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic testosterone deficiency

          -  Intend to undergo testosterone therapy at Men's Health Boston

          -  Total testosterone <350ng/dL or free testosterone <1.5ng/dL

        Exclusion Criteria:

          -  Type 1 diabetes

          -  Use of exogenous testosterone or clomiphene citrate

          -  Known karyotype abnormalities

          -  Seizure disorders

          -  Malignancy
Male
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment