araag2/NLI4PR huggingface dataset:
Clinical trial: INdividualized ITI Based on Fviii(ATE) Protection by VWF (NCT03204539)

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of congenital Hemophilia A and baseline FVIII ≤2%.

          2. Weight ≥ 5 kg

          3. History of FVIII inhibitor titer ≥5 BU

          4. Current FVIII inhibitor titer ≥5 BU or ≥0.6 BU and failed ITI defined by FVIII
             recovery <66% normal and half-life <6 hours

          5. Adequate venous access for daily concentrate infusions

          6. For participants <18 years, a parent or guardian willing and able to provide informed
             consent with verbal or written assent from the child if require by the local
             institution. For participants ≥18 years, a willingness and ability to provide informed
             consent from the subject.

          7. Ability to comply with study related treatments, evaluations, and follow-up.

        Exclusion Criteria:

          1. Acquired hemophilia

          2. Congenital or acquired bleeding disorder in addition to Hemophilia A

          3. ITI factor replacement regimen within the past one month unless there is clear
             evidence of ITI failure with no reduction in inhibitor titer over the past two months

          4. HIV positive with viral load ≥200 particles/μL or ≥400,000 copies/mL

          5. Rituximab within the past 3 months

          6. IVIG within the past 1 month

          7. Treatment with other immunosuppressive drugs within the past 1 month (excluding
             intermittent steroid use for asthma)

          8. Concomitant experimental treatment

          9. History of hypersensitivity to plasma-derived VWF- or FVIII-containing concentrates

         10. Elective surgery planned in the next 6 months (excluding vascular access procedure)

         11. Any condition or chronic illness, which in the opinion of the investigator makes
             participation ill-advised

         12. Inability or unwillingness to complete required screening, follow-up, and exit studies
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effect of Administration of the Combination Bezafibrate More Berberine on Lipid Profile in Patients With Dyslipidemia (NCT02548832)

Eligibility criteria:
Inclusion Criteria:

        A. Men and women B. Accomplished age 30 to 60 years

        C. Diagnosis of mixed dyslipidemia established to meet the following criteria:

          -  Total cholesterol> 200 mg / dL

          -  Triglycerides> 150 mg / dL 27 D. BMI of 25 kg / m2 to 39.9 kg / m2, weight stable over
             the past three months, defined as a variability in the lower body weight of 5%.

        E. No drug treatment for lipid profile 3 months prior to baseline. F. Women must ensure a
        non-hormonal method to avoid pregnancy during the study period G. written information
        consent

        Exclusion Criteria:

        A. Removal for informed consent letter B. Loss of monitoring C. Presence of serious adverse
        event D. Adherence to treatment <80% E. Consumption of drugs known about lipid profile,
        glucose metabolism, blood pressure and body weight during the intervention period influence
        F. Intolerance or not tolerability or hypersensitivity to the compounds used in the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Contradiction
Clinical trial: Arthroscopic Diagnosis and Treatment of Dorsal Wrist Syndrome in Patients With Synovial Hypertrophy (NCT04648527)

Eligibility criteria:
Inclusion Criteria:

          1. Men or women

          2. Age 18-65 years old, both included

          3. Diagnose of primary dorsal wrist syndrome, defined as:

             3.1 Radiocarpal dorsal focal pain 3.2 Pain increases in hyperextension of the wrist
             and in axial load 3.3 X-rays and MRI without significant findings 3.4 Watson test,
             extension finger test, Kleinman shuck test, distal radio-ulnar ballottement test,
             fovea sign all of them negatives and absence of tenosynovitis of the extensor tendons.

          4. Refractory to conservative treatment consisting in at least 3 months of physical
             therapy.

          5. Presence of a hypertrophy of the dorsal synovial of the wrist diagnosed through direct
             visualization in wrist arthroscopy.

          6. Other diagnoses excluded through wrist arthroscopy

        Exclusion Criteria:

          1. Hand or wrist fractures

          2. Arthritis

          3. Carpal boss

          4. Scapho-lunate ligament tears

          5. Luno-triquetral ligament tears

          6. Triangular fibrocartilage tears

          7. Bone necrosis

          8. Systemic arthritis as rheumatoid arthritis, psoriasic arthritis, gouty arthritis,
             etc.)

          9. Dorsal or volar ganglions

         10. Distal radio-ulnar joint injury or instability

         11. Hand or wrist infections or tumors
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Use of Infrared Spectroscopy in Fast Septic Arthritis Diagnosis (NCT04004962)

Eligibility criteria:
Inclusion Criteria:

          -  patients over 18 year old

          -  patients with an acute arthritis defined by an evolution of less than 6 weeks

          -  patients benefiting from joint fluid puncture for diagnostic purposes in the
             rheumatology hospitals participating in the study

          -  patients who received information about the protocol and have not expressed opposition
             to participate

        Exclusion Criteria:

          -  patients opposing the study

          -  protected major (safeguard justice, trusteeship and guardianship) and persons deprived
             of liberty
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Syncope: Pacing or Recording in the Later Years (NCT01423994)

Eligibility criteria:
Inclusion Criteria:

        -Patients are eligible if they have:

          -  >1 syncopal spell within 1 year preceding enrollment, and

          -  bifascicular block on a 12-lead ECG, and

          -  Age > 50 years and

          -  written informed consent. Syncope will be defined based on history using a
             standardized form.

        Exclusion Criteria:

        -Patients will be excluded if they have criteria related to study strategies, including:

          1. previous pacemaker, ICD, or Implantable Loop Recorder in situ,

          2. ACC/AHA/HRS Class I indication for permanent pacing or ICD implantation,

          3. left ventricular ejection fraction < 35% mandating ICD therapy,

          4. contra-indication to a transvenous pacemaker such as artificial tricuspid valve or
             active sepsis.

             -Patients will also be excluded if a potential competing cause of syncope poses a
             threat to life, such as:

          5. hypertrophic cardiomyopathy,

          6. documented sustained ventricular tachycardia or

          7. inducible, sustained monomorphic ventricular tachycardia on EP study.

             -They will be excluded if they have:

          8. a history of myocardial infarction within 3 months prior to enrollment, and

          9. a major chronic co-morbid medical condition that would preclude 24 months of
             follow-up.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Contradiction
Clinical trial: Improving the Quality of Patient Care by Using a Clinical Expert System. (NCT00430755)

Eligibility criteria:
Inclusion Criteria:

          -  All inpatients in a hospital environment

        Exclusion Criteria:

          -  Inability to give an informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Rare Iron Overloads Except C282Y Homozygosity : Description and Characterization. (NCT01541813)

Eligibility criteria:
Inclusion criteria:

          -  Biological profile suggesting hepcidin deficiency:

               -  high serum iron (> 25μmol / l) checked at least 2 times.

               -  increased transferrin saturation coefficient (> 50 %) checked at least 2 times,
                  and calculated from transferrinemia.

          -  Proved hepatic iron overload: using a dosage of iron hepatic concentration either on
             hepatic biopsy, or by MRI according to the method of iron overload quantification. A
             threshold of 100 µmol / g is set.

          -  Patient's written consent for examination and collection of genetic data to set the
             diagnosis.

        Non inclusion criteria:

          -  HFE hemochromatosis: C282Y/C282Y homozygosity

          -  Treatment by iterative phlebotomies (more than 2 phlebotomies)

          -  Hematological diseases with dyserythropoiesis and/or repeated transfusions

          -  Low haptoglobin level, suggesting chronic hemolysis or myelodysplasia

          -  Long-term iron oral and/or parenteral supplementation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment
Clinical trial: Remifentanil-dexmedetomidine Anesthesia With a Caudal for Elective Surgery. (Remi-dex) (NCT02799589)

Eligibility criteria:
Inclusion Criteria:

          -  Children aged 1 - 3 years undergoing urologic surgery (circumcision, hydrocele repair,
             orchidopexy, mild hypospadias) or inguinal hernia repair

          -  American Society of Anesthesiologist Physical Status (ASA-PS) I or II

          -  Eligible for caudal block

          -  Parental/legal guardian consents for study '

        Exclusion Criteria:

          -  Allergy to remifentanil, dexmedetomidine or ropivacaine

          -  Family history of malignant hyperthermia

          -  Parental/legal guardian refusal

          -  ASA-PS ≥ 3

          -  Symptoms of upper respiratory infection (URI) within the 2 weeks prior to surgery

          -  Known spinal deformity, presence of sacral dimple, or signs of infection at the site
             of the caudal block (e.g. diaper rash, skin redness or tenderness).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 3 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: Development and Assessment of a Spanish-Language Hearing Loss Toolkit for Self-Management (NCT04534387)

Eligibility criteria:
Inclusion Criteria:

          1. Participants will include community-dwelling, Spanish-speaking (monolingual or
             bilingual) adults over age 50 who self-identify as Hispanic/Latino

          2. Clinically-significant hearing loss defined as either greater than 25 decibels hearing
             leve (dB HL) thresholds at 2 or more frequencies from 250 - 8000 hertz (Hz) and/or
             significant self-reported hearing difficulties as defined by a score of greater than 8
             on the Hearing Handicap Inventory - Screening measure for adults/elderly.

        Exclusion Criteria:

          -  Individuals who are not fluent Spanish-speakers or who do not self-identify as
             Hispanic/Latino are not eligible to participate in this study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment