araag2/NLI4PR huggingface dataset:
Clinical trial: Prevention of Cystitis. (NCT03744338)

Eligibility criteria:
Inclusion Criteria:

          -  Woman aged 18 to 65, consultant in general medicine. (Any patient meeting the
             inclusion criteria may choose to answer the questionnaire in the waiting room of
             general practitioners selected by lot.)

        Exclusion Criteria:

        -
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Osteoporosis Associated Vertebral Fractures - Medical and Socio-economic Aspects in Austria (NCT02403726)

Eligibility criteria:
Inclusion Criteria:

        -patients older than 50 years of age with vertebral fractures at the thoracic or lumbar
        spine caused by a low-energy trauma or without any trauma, or with vertebral fractures at
        the thoracic or lumbar spine with typical osteoporotic deformity of the vertebrae (wedge,
        fish, or flat)

        Exclusion Criteria:

          -  patients younger than 50 years of age

          -  vertebral fractures at the cervical spine

          -  vertebral fractures at the thoracic or lumbar spine caused by a high-energy trauma
             (motor-vehicle accident, sports-related accident, fall from a considerable height)

          -  patients suffering from a malignancy, making a pathological fracture presumably,
             patients with vertebral fractures, whose dataset of follow-up monitoring was lacking,
             to make an evaluation of osteoporotic involvement impossible
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Semen Analysis and Insight Into Male Infertility (NCT04178954)

Eligibility criteria:
Inclusion Criteria:

          -  infertile males

        Exclusion Criteria:

          -  suergery
Male
No healthy subjects accepted to join the trial.
Subject must be at least 15 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment
Clinical trial: Insulin Resistance in Idiopathic Oligospermia and Azoospermia (NCT01509482)

Eligibility criteria:
Inclusion Criteria:

          -  sperm count less than 10 million per milliliter

          -  non-obstructive azoospermia

        Exclusion Criteria:

          -  high FSH ( > 10 mIU/ ml )

          -  high prolactin ( > 36 mIU/ml )

          -  abnormal karyotype

          -  AZF
Male
Accepts Healthy Volunteers
Subject must be at least 25 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Genetic Causes of Growth Disorders (NCT02311322)

Eligibility criteria:
-  INCLUSION CRITERIA:

        If a subject meets any one of these criteria, he/she will potentially be eligible to
        participate:

          -  Short stature (height less than - 2 SDS), either currently or previously - or

          -  Tall stature (height greater than + 2 SDS) or

          -  Bone age delay (greater than 3 years) or

          -  Bone age advancement (greater than 2.5 years or greater than 1.5 years with short
             stature) or

          -  Predicted adult height < - 2SD

          -  Growth disorder that was treated promptly, thus maintaining the child s height within
             the normal range, e.g. a subject with congenital growth hormone deficiency or multiple
             pituitary hormone deficiency of unknown genetic etiology who received growth hormone
             treatment beginning in early life or

          -  Family member of subjects who meet any of the above criteria

          -  Subjects have a current height at a low normal percentile but has short adult height
             prediction based on bone age (> 5 inches shorter than mid-parent height)

        In addition, subjects are only eligible, if, the pedigree suggests a monogenic inheritance,
        and, in the judgement of the investigators, there is a reasonable likelihood of identifying
        a novel gene responsible for the condition.

        EXCLUSION CRITERIA:

          -  A non-genetic disorder or condition, either congenital or acquired, that explains the
             growth abnormality, for example, pituitary injury, chronic thyroiditis, whole body
             irradiation, or celiac disease.

          -  In the opinion of the investigators, there is an established diagnosis of a genetic
             disorder or condition that explains the growth abnormality and for which the molecular
             genetic etiology has already been identified, for example, SHOX deficiency,
             hypochondroplasia, or Noonan syndrome.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm (NCT04766723)

Eligibility criteria:
Inclusion Criteria:

        - Score of ≥ 2 (at least 1 cm tremor amplitude) in at least two out of three maneuvers of
        test item 4 (upper limb tremor) confirmed by an independent TETRAS expert by means of video
        assessment.

        Exclusion Criteria:

          -  History or presence of day-to-day fluctuations in ET which would jeopardize meaningful
             tremor assessment over time, e.g. severe tremor on one day and minimal or no tremor on
             another day.

          -  Other neurological signs, such as dystonia, ataxia, or parkinsonism, which in the
             judgment of the investigator could interfere with the ET diagnosis and/or assessment
             of ET in ULs.

          -  Tremor types other than ET
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: New Diagnostic Strategy in Hypertrophic Cardiomyopathy (NCT02520856)

Eligibility criteria:
Inclusion Criteria:

          -  patient with newly diagnosed hypertrophic cardiomyopathy (HCM), based on conventional
             echocardiographic criteria.The diagnosis of HCM will be considered definite in the
             presence of left ventricle hypertrophy without cavity dilatation and without other
             cardiac or systemic disease able to produce the magnitude of hypertrophy.

        Exclusion Criteria:

          -  Associated cardiac or non cardiac disease known to cause left ventricle hypertrophy
             (uncontrolled systemic Hypertension, severe aortic stenosis)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment
Clinical trial: Stimulated Intrauterine Insemination Cycles and Unstimulated Intrauterine Insemination Cycles in Couples With Unexplained Infertility (NCT02461173)

Eligibility criteria:
Inclusion Criteria:

          -  Unexplained infertility

        Exclusion Criteria:

          -  Known allergy to FSH

          -  Diabetes, hypertension, known cardiac, renal or liver disease.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Extracapsular Arthroscopic Treatment for Refractory Tennis Elbow--Mid-and-short Term Retrospective Study of 50 Cases (NCT04454047)

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis was refractory tennis elbow;

          2. Standard extracapsular method was used for surgery.

        Exclusion Criteria:

          1. Patient had past history of joint infection, joint tuberculosis, or osteomyelitis, or
             the upper limb had undergone surgery within the past 6 months;

          2. Diagnosis was combined with severe heart, brain, kidney, or another organ dysfunction;

          3. Case was complicated with other serious elbow joint diseases or injuries;

          4. Patient did not sign the informed consent form.
No condition on gender to be admitted to the trial.




Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? Contradiction
Clinical trial: Autologous Stem Cells in Osteoarthritis (NCT01485198)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with knee osteoarthritis grade II or III of the Kellgren-Lawrence
             radiographic scale

          -  Age > 30 years

        Exclusion Criteria:

          -  Neurodegenerative, autoimmune, genetic or psychiatric diseases

          -  Active infection

          -  Recent joint infection

          -  Knee surgery history

          -  Knee joint fracture history
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment