araag2/NLI4PR huggingface dataset:
Clinical trial: Inguinal Hernia Management: Watchful Waiting vs. Tension-Free Open Repair (NCT01922674)

Eligibility criteria:
Inclusion Criteria:

          -  18 years of age or older (19 years in Nebraska)

          -  Male

          -  Diagnosis of inguinal hernia (patients with bilateral and recurrent hernias are
             eligible)

          -  Inguinal hernia that is either completely asymptomatic or minimally symptomatic (does
             not interfere with normal activities

          -  Informed consent for randomization

        Exclusion Criteria:

          -  A hernia that could not detected on physical examination

          -  American Society of Anesthesia (ASA) Class IV or V

          -  Evidence was present of an acute hernia complication such as bowel obstruction,
             strangulation, peritonitis, or perforation

          -  Local or systemic infection

          -  Presence of pain and discomfort associated with the hernia that limits usual
             activities

          -  A history of recent (within six weeks of visit) onset of difficulty in reducing a
             hernia that was previously easily reduced

          -  Participation in another clinical trial

          -  Female
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Evaluating Novel Approaches for Estimating Awake and Sleep Blood Pressure (NCT04307004)

Eligibility criteria:
Inclusion Criteria:

          -  Mean screening systolic blood pressure of 110 to < 160 mm Hg at most recent visit

          -  Mean screening diastolic blood pressure of 70 to <100 mm Hg at most recent visit

        Exclusion Criteria:

          -  Currently taking antihypertensive medications

          -  Known to be currently pregnant

          -  History of sleep apnea

          -  History of heart attack, stroke, or any cardiovascular disease

          -  History of arrhythmia (e.g. - atrial fibrillation or ventricular tachycardia)

          -  Completed ambulatory blood pressure monitoring in the past year

          -  Second shift, overnight, or jobs that will not allow ambulatory blood pressure device
             to measure every 30 minutes for 24 hours.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 19 Years old.
Subject must be at most 87 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Safety Study of XP12B in Women With Menorrhagia (NCT00113568)

Eligibility criteria:
Inclusion Criteria:

          -  Women with menorrhagia

          -  18-49 years of age

          -  Regularly occuring menstrual periods

        Exclusion Criteria:

          -  History or presence of clinically significant disease or abnormalities that might
             confound the study

          -  History of bilateral oophorectomy or hysterectomy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 49 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Fitness and Exercise for People With Arthritis (NCT00252070)

Eligibility criteria:
Inclusion Criteria:

          -  Self-reported doctor-diagnosed arthritis

          -  No physical limitations precluding exercise participation

          -  Negative screen for CVD (PAR-Q)

          -  Age 20+

          -  English or Spanish speaking

        Exclusion Criteria:

          -  Presence of any condition for which exercise is contraindicated

          -  Physical inability to complete exercise program
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Three-Year Trial on a New Testosterone Gel (NCT00204269)

Eligibility criteria:
Inclusion Criteria:

        men with

          -  hypergonadotropic hypogonadism

          -  hypogonadotropic hypogonadism

          -  late-onset hypogonadism

        combined with an initial Testosterone serum level of < 11 nmol/l

        Exclusion Criteria:

          -  known or suspected carcinoma of the prostate

          -  clinically relevant abnormalities in clinical chemistry or haematology

          -  any severe medical conditions at the opinion of the investigator
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Treatment of Severe Alzheimer's Disease: Evaluation of Efficacy and Safety of Galantamine Hydrobromide in a Controlled Study (NCT00216593)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Alzheimer's type dementia, rated as severe

          -  progressive worsening of memory and other cognitive functions

          -  brain imaging (CTor MRI scan) within last 3 years

          -  ability to be mobile (aided or unaided) with sufficient vision and hearing to comply
             with testing.

        Exclusion Criteria:

          -  Dementia caused by cerebrovascular disease

          -  disturbances of consciousness, delirium, psychosis

          -  severe aphasia

          -  or major sensorimotor impairment

          -  cognitive impairment due to acute cerebral trauma, hypoxic cerebral damage, vitamin
             deficiency, infections, primary of metastatic cerebral neoplasia, endocrine or
             metabolic disease or mental retardation, pregnant or nursing women or those without
             adequate contraception.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Diagnostic Value of DECT Scan Compared to Diagnostic Needle Aspiration (NCT03038386)

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  Mono or oligo arthritis (2-3 swollen joints)

          -  Indication for diagnostic aspiration of an inflamed joint in which gout is one of the
             possibilities

        Exclusion Criteria:

          -  Polyarthritis ( up to 4 swollen joint);

          -  Chrystal proven gout in history

          -  Patient is on uric acid lowering therapy (Allopurinol, Benzbromaron, Febuxostat)

          -  Hip arthritis*

          -  Metal or prosthesis of the inflamed joint

          -  Highly suspicion of infectious arthritis

          -  Pregnancy

          -  Contra indication of joint aspiration (skin infection, hemophilia)

          -  No informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: An Investigational Drug in Patients With Osteoarthritis (0663-073) (NCT00092755)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with osteoarthritis of the hip or knee who use current approved medication
             (nonsteroidal anti-inflammatory drugs (NSAIDs)) or tylenol to treat the symptoms of
             their osteoarthritis. Patients taking NSAIDs are required to discontinue using these
             drugs and their symptoms must become worse.

        Exclusion Criteria:

          -  Patients with certain medical conditions may not be allowed to participate. These
             conditions will be reviewed with the study physician.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Enhanced Recovery After Surgery In Hirschsprung Disease (NCT02776176)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Hirschsprung Disease

        Exclusion Criteria:

          -  with other disease

          -  receive emergency surgery

          -  need to do the ostomy

          -  full colonic Hirschsprung Disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 14 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Entailment
Clinical trial: Microaspiration in Pulmonary Fibrosis (NCT01150591)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of IPF

          -  Ability ot provide informed consent

        Exclusion Criteria:

          -  History of fundoplication or other gastroesophageal surgery

          -  Too ill to undergo bronchoscopy in the opinion of the investigator
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? Entailment