araag2/NLI4PR huggingface dataset:
Clinical trial: Phase I/II Study of SRP-4053 in DMD Patients (NCT02310906)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with DMD, genotypically confirmed.

          -  Intact right and left biceps muscles or an alternative upper arm muscle group.

          -  Stable pulmonary and cardiac function.

          -  Minimum performance on 6MWT, North Star Ambulatory Assessment, and rise (Gowers) test
             as specified in the study protocol.

          -  On a stable dose of corticosteroids for at least 6 months.

        Exclusion Criteria:

          -  Previous treatment with the experimental agents BMN-195 (SMT C1100) or PRO053.

          -  Current or previous treatment with any other experimental treatments within 12 weeks
             prior to study entry.

          -  Major surgery within the last 3 months.

          -  Presence of other clinically significant illness.

          -  Major change in physical therapy regime within the last 3 months.

        Other inclusion and exclusion criteria may apply.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 15 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Mifepristone Dynamic Testing for Diagnosis for Central Adrenal Insufficiency (NCT04588688)

Eligibility criteria:
Inclusion Criteria (1 of the following):

          -  Completed insulin tolerance testing (ITT) at University of Michigan from 2012 to
             present.

          -  Are scheduled to complete ITT.

          -  Are clinically suspected to have adrenal insufficiency but have not undergone ITT.

        Exclusion Criteria:

          -  Female patients who are of child-bearing potential (defined as a sexually mature woman
             who has not undergone hysterectomy, bilateral oophorectomy bilateral salpingectomy or
             bilateral tubal ligation/occlusion, at least 12 weeks prior to screening, or who has
             not been naturally postmenopausal for at least 24 consecutive months prior to study
             enrollment) and not using non-hormonal contraception.

          -  Female patients not willing to use non-hormonal contraception for one month following
             treatment.

          -  Women who are pregnant or breast feeding.

          -  Patients with an existing diagnosis of adrenal insufficiency who are on any
             glucocorticoid replacement other than oral hydrocortisone or prednisone.

          -  Patients on medications that are strong CYP3A

          -  Patients taking other medications metabolized by CYP3A

          -  Patients who have a history of QT prolongation and patients with any recent abnormal
             electrocardiogram (ECG).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Healing of Post-ext Sites Using Bovine Bone Mineral: a CBCT and Histologic RCCT (NCT01800149)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy adult patients with one or more teeth to be extracted, from premolar to
             premolar

        Exclusion Criteria:

          -  Heavy smokers (more than 10 cig per day)

          -  Current Pregnant patients

          -  History of malignancy

          -  History of radiotherapy or chemiotherapy in the past 5 years

          -  Long term steroidal or antibiotic therapy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Effect of CoVid-19 (CoronaVirusDisease-19) and Exercise on Myocardial Fibrosis and Ventricular Arrhythmias (NCT04726150)

Eligibility criteria:
Inclusion Criteria:

          -  Athletes (professional or recreational but aiming to compete at a national or
             international level), performing mixed-type or endurance sports as defined by
             Pelliccia et al. who:

               1. have recovered from a proven (either by PCR (Polymerase Chain Reaction), serology
                  or chest Computed Tomography) COVID-19 infection

               2. are more than 1-month post onset of symptoms or the first positive PCR and

               3. are willing to start (or are) exercising again

        Exclusion Criteria:

          1. known prior cardiac fibrosis

          2. known or newly diagnosed coronary artery disease

          3. allergy or contraindications for gadolinium contrast.

          4. unwillingness or impossibility to give informed consent

          5. Presence of edema on the CMR
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Entailment
Clinical trial: Use of a TGA and TEM in the Assessment of the Efficacy of Treatment With APCC or rFVIIa (NCT01856751)

Eligibility criteria:
Inclusion Criteria:

          -  patients with acquired haemophilia

          -  patients with congenital haemophilia A with inhibitor

        Exclusion Criteria:
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: High-intensity Focused Ultrasound in Treatment of Uterine Adenomyosis (NCT02954757)

Eligibility criteria:
Inclusion Criteria:

          -  Age >40 years old, with no future childbearing plans

          -  Age >30 years old, who has tubal sterilization

          -  Significant symptoms related to adenomyosis, intractable to standard medical therapy,
             or patient considering radiological intervention (uterine fibroid embolization) or
             surgery.

          -  Clinical uterine size less than 20 weeks gestation

          -  Localized adenomyotic lesion or adenomyoma identified of less than 10 cm in diameter
             as judged by contrast MRI, involving only anterior or posterior uterine wall and not
             both.

          -  No laparotomy scars.

          -  Women should be able to give consent.

        Exclusion Criteria:

          -  Other pelvic or uncontrolled systemic diseases

          -  Confirmed or suspected pregnancy

          -  Patients who are unable to communicate with researchers during the treatment

          -  Patients who are contraindicated for MRI examination

          -  Patients with thick abdominal wall (>5 cm, as measured by MRI)

          -  Presence or history of acute pelvic inflammatory disease or any pelvic malignancy

          -  History of lower abdominal surgery, known severe pelvic endometriosis and/ or
             extensive pelvic adhesion

          -  Presence of significant sized fibroids which may interfere with the treatment or
             affect the outcome measures
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Laparoscopic Assisted Pull-through Versus Other Surgical Procedures for Treatment of Hirschsprung Disease (NCT03269812)

Eligibility criteria:
Inclusion Criteria:

          1. Age from 6months to 3 years.

          2. Both sexes.

          3. Classic and long segment Hirshsprung.

          4. Total a ganglionic colon.

          5. Hirshsprung disease with leveling colostomy

        Exclusion Criteria:

          1. Patients <6 months and >3 years.

          2. Short and Ultra-short Hirshsprung.

          3. Recurrent cases of Hirshsprung.

          4. Other contraindication of laparoscopy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 36 Months

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Entailment
Clinical trial: Eﬀects of Reparel™ Knee Sleeve on Knee Osteoarthritis (NCT04743921)

Eligibility criteria:
Inclusion Criteria:

          -  osteoarthritis visible on knee radiograph

          -  patient opting for non-surgical treatment

          -  no corticosteroid knee injection for 90 days prior to consent

          -  no corticosteroid knee injection for 90 days following consent

        Exclusion Criteria:

          -  bilateral symptomatic knee osteoarthritis

          -  prior surgery on the knee of interest

          -  hardware present on the knee of interest

          -  gross instability detected on physical exam

          -  malignancy in the knee of question
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Laryngopharyngeal Reflux Before and After Cricopharyngeal Myotomy (NCT01880892)

Eligibility criteria:
Inclusion Criteria:

          -  symptoms of gastroesophageal reflux

          -  presence of Zenker's diverticulum or cricopharyngeal hypertrophy

          -  undergoing surgery for Zenker's diverticulum or cricopharyngeal hypertrophy with
             endoscopic laser cricopharyngeal myotomy

          -  at least 18 years old

        Exclusion Criteria:

          -  pregnant women

          -  children

          -  prisoners

          -  adults lacking capacity to consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: Prediction of Response to Intra-articular Injections of Hyaluronic Acid for Knee Osteoarthritis (NCT01557868)

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic knee osteoarthritis presenting to physician's office

          -  Radiographic evidence of knee osteoarthritis

          -  Age 18 years or older

          -  Failed minimum of 3 months of non-operative treatment, including, but not limited to,
             Tylenol, anti-inflammatory medication, cortisone injection, physical therapy, bracing,
             and/or heel wedge

          -  Symptoms for at least 3 months

        Exclusion Criteria:

          -  Associated ligamentous instability

          -  History of deep knee infection

          -  Candidate for total knee arthroplasty or arthroscopy

          -  Peripheral neuropathy.

          -  X-rays that are completely negative and only MRI evidence or arthroscopic evidence
             (from previous arthroscopy) of OA.

          -  Prior HA injections at any point in the past

          -  Chondrocalcinosis

          -  Patients with precautions or contraindications for viscosupplementation use

          -  Cortisone injection within past 3 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment