araag2/NLI4PR huggingface dataset:
Clinical trial: Study Comparing Blood Levels of ReFacto and Advante in Hemophilia A (NCT00168051)

Eligibility criteria:
Inclusion Criteria:

          -  Severe hemophilia A

          -  Previously treated patients with at least 150 exposure days to any Factor VIII product

        Exclusion Criteria:

          -  Hypersensitivity to any recombinant Factor VIII product

          -  History of or current Factor VIII inhibitor

          -  Bleeding episode or other reason requiring Factor VIII treatment within 3 days of
             study
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 64 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: Randomized Fracture Liaison Services (NCT03178799)

Eligibility criteria:
Inclusion criteria：

          -  Age>=50

          -  New hip fracture from orthopedic ward

          -  Newly identified vertebral fracture (either morphological or clinical)/ old hip
             fracture without osteoporosis treatment referred by team physicians either inpatients
             or outpatients

          -  Willing to accept 10 years of follow-ups.

        Exclusion criteria

          -  Traumatic or pathologic fractures

          -  Atypical femoral shaft fracture

          -  Participating in other medication intervention trials

          -  Less than 2 years of life expectancy judged by team physicians

          -  Incapable of accepting evaluation for cognitive, communication, and physical problems
             judged by team physicians or coordinators.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Molecular Analysis of Oncogenes and Resistance Mechanisms in Lung Cancer (NCT01580982)

Eligibility criteria:
Inclusion Criteria:

          1. Patients undergoing investigation or treatment for thoracic cancers with
             oncogene-targeted therapies

          2. Aged 18 years or older

          3. Either a) have suspected tumor progression or other condition that dictates a
             standard-of-care palliative, therapeutic, or diagnostic intervention including but not
             limited to procedures such as bronchoscopic biopsy, computed tomography (CT) or
             ultra-sound (US)-guided biopsy, thoracentesis, video assisted thoracoscopic (VATS)
             pleurodesis, lobectomy, adrenalectomy or pleural catheter placement, providing tumor
             specimen appropriate molecular analysis or b) have previously had biopsy/surgical
             intervention with tumor tissue at University of Colorado or an outside institution
             available for medullar analysis.

          4. Patients must have the ability to understand and willingness to sign an informed
             consent document.

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: A Multi-site Trial Comparing Lichtensteins Operation and Prolene Hernia System in Inguinal HErnia Repair (NCT00184483)

Eligibility criteria:
Inclusion Criteria:

          -  Primary unilateral groin hernia in adult

        Exclusion Criteria:

          -  recurrence warfarin treatment bilateral groin hernia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Real-time fMRI Neurofeedback in Patients With MCI (NCT04020744)

Eligibility criteria:
Inclusion Criteria:

          -  Intact activities of daily living

          -  Fluent in German

          -  Normal/corrected-to-normal vision

          -  Written informed consent

        Exclusion Criteria:

          -  Dementia

          -  Current/lifetime severe psychiatric or neurological disorder

          -  History of seizures

          -  Psychotropic medication

          -  Currently/lifetime drug or alcohol abuse

          -  Brain damage

          -  Magnetisable implants
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Testing a Body-functionality Intervention for Body Image in Individuals With Skin Conditions (NCT04445974)

Eligibility criteria:
Inclusion Criteria:

          -  Individuals with dermatological condition (including conditions that affect the skin,
             hair and/or nails). This includes, but is not limited to, acne, eczema, alopecia,
             psoriasis, vitiligo, rosacea, dermatitis, hyperpigmentation, hidradenitis suppurativa
             (HS), hyperhidrosis, hirsutism, neurofibromatosis, onychomycosis, melasma, cysts,
             herpes, ichthyosis, and lichen sclerosus.

          -  Individuals self-reporting that their body image is affected by their skin condition.

          -  Sufficient English to complete the measures and writing exercises

          -  Access to the internet.

        Exclusion Criteria:

          -  As the focus of this research is on skin disease, individuals living with visible
             differences as a consequence of trauma (e.g. scarring from burns or scarring from
             traumatic injury) are not eligible to participate in this study.

          -  Individuals who do not feel their body image is affected by having a dermatological
             condition.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Entailment
Clinical trial: Tencel vs. Standard Cotton Therapeutic Garments as an Adjunct Treatment for Moderate to Severe Atopic Dermatitis in Children (NCT03843437)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of moderate or severe atopic dermatitis based on Eczema Area and Severity
             Index (EASI) score (moderate=6-22.9; severe=23-72)

          -  At least one active patch of atopic dermatitis at time of study

          -  Parent/guardian able to give informed consent

        Exclusion Criteria:

          -  Systemic medication or oral steroids within past 3 months (includes light therapy),

          -  Started new atopic dermatitis treatment regimen within the past month,

          -  Using wet/dry wraps > once/week
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 6 Years

Patient description (medical language): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient description (patient's own words): I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Does the patient match the trial criteria? Entailment
Clinical trial: Effects of Polyphenols on Iron Absorption in Iron Overload Disorders. (NCT03453918)

Eligibility criteria:
Inclusion Criteria:

          -  18 years old and over

          -  Written consent.

          -  For DIOS Group : at least one criteria of the metabolic syndrome as defined by the
             International Diabetes Federation, associated with hepatic iron overload measured by
             MRI (at least 50 µmol/g) or by hepatic biopsy.

          -  For Genetic Haemochromatosis type 1 Group: homozygosity mutation C282Y in HFE gene ;
             patients undergoing therapeutic phlebotomies.

        Exclusion Criteria:

          -  Persons under guardianship

          -  Body-weight less than 45 kg

          -  Hemoglobin less than 9 g/dL.

          -  Intestinal malabsorption of any cause

          -  Current use or previous use during the last 2 months of iron supplement.

          -  Current use or previous use during the last 2 months of treatment interacting with
             iron absorption (increasing like C vitamin or decreasing like iron chelators)

          -  Other causes of hyperferritinemia : chronic inflammatory syndrome, porphyria,
             hyperferritinemia-cataract-syndrome, chronic alcohol consumption, chronic hemolysis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment
Clinical trial: Multiple Breath Washout (MBW) Using Sulfur Hexafluoride Reference Values and Influence of Anthropometric Parameters (NCT04099225)

Eligibility criteria:
Inclusion Criteria:

        non-smoker

          -  no history of pulmonary disease

          -  absence of dyspnoea, cough, thoracic pain

          -  no self-reported smoking history

          -  normal lung function testing

               -  normal shape of flow-volume curve

               -  normal shape of flow-pressure curve

               -  FEV1/FVC >70% (forced expiratory volume in 1 second / forced vital capacity)

               -  TLC > 80% of predicted (total lung capacity)

               -  TLCO/VA > 80% of predicted (transfer factor corrected for ventilated alveolar
                  volume)

               -  R5 < 150% of predicted (resistance at 5Hz, impulse oscillometry)

        smoker

        - as above, but with self-reported smoking history >10 pack years

        Exclusion Criteria:

          -  unwilling or unable to give informed consent

          -  history of any respiratory disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Imaging Parameters to Predict Future Vertebral Fracture in Osteoporosis (NCT01653873)

Eligibility criteria:
Inclusion Criteria:

          -  All the patients received vertebroplasty treatment between 2005.01-2011.12 with 2nd
             fracture in the vertebral column.

        Exclusion Criteria:

          -  No image available
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction