araag2/NLI4PR huggingface dataset:
Clinical trial: Body Mass Index and Audiology Function (NCT03172663)

Eligibility criteria:
Inclusion Criteria:

        It will include 50 subjects whose:

          -  Age ranges from 10 to 40 years old.

          -  Body Mass Index more than the 85th percentile.

          -  male and female will be included

        Exclusion Criteria:

          -  External or middle ear disease that causes conductive hearing loss such as otitis
             media, otomycosis, perforated drum, tumors, dislocation of the ossicles.

          -  High environmental noise exposure which causes acoustic trauma such as exploration,
             fire shots and noise in industries.

          -  ototoxic drug intake such as Aspirin, Aminoglycosides, Erythromycin, Vancomycin
             Streptomycin, Kanamycin, Neomycin, Gentamycin, Tobramycin, Lasix, Cisplatin, Nitrogen
             Mustard, and Vincristine, and Quinine.

          -  Major neurological or psychiatric diseases brain tumor, vestibular Schwannoma, stroke,
             acoustic neuroma, encephalitis, meningitis, and depression.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction
Clinical trial: Resolution of Comorbidities & Safety and Efficacy of Greater Curvature Plication in Obese Patients (NCT02315105)

Eligibility criteria:
Inclusion Criteria:

          1. Subject is willing to give consent and comply with evaluation and treatment schedule

          2. 18 to 65 years of age

          3. Have a BMI > 30 with one or more significant co-morbid medical conditions which are
             generally expected to be improved, reversed, or resolved by weight loss. these
             conditions include but are not limited to:

               -  Hyperlipidemia

               -  Type 2 diabetes

               -  Mild Obstructive Sleep Apnea

               -  Hypertension

               -  Osteoarthritis of the hip or knee

          4. Agree to refrain from any type of weight-loss drug ( prescription or OTC) or elective
             procedure that would affect body weight for the duration of the trial

          5. HbA1C < 11 %

          6. For subjects who have Type 2 Diabetes, the anti-diabetic medication regimen is no more
             complex than oral metformin plus one oral sulfonylurea plus once daily insulin
             injection.

          7. Ability to self-pay for the procedure and follow up.

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Using Online Videos to Supplement Emergency Department Discharge Instructions (NCT01361932)

Eligibility criteria:
Inclusion Criteria:

          -  Age > 16, or < 16 and accompanied by a legal guardian

          -  Has one of 38 ED discharge diagnoses

          -  Fluent in English, or caregiver fluent

          -  Has access to a computer, with internet access, in the next 4 days

          -  Has access to a telephone

        Exclusion Criteria:

          -  Age < 16 when unaccompanied by a legal guardian

          -  Decreased level of consciousness at ED discharge (eg palliative patient)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient description (patient's own words): I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Does the patient match the trial criteria? Entailment
Clinical trial: Trigger-point Blockade in Persistent Pain After Open Groin Hernia Repair (NCT02065219)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with persistent pain (< 6 mo) after open groin hernia repair

          -  Patients with maximal pain area 3 cm or less from the superficial inguinal ring

          -  Patients living in the Capital Region of Denmark (Region Hovedstaden) or the Region of
             Zealand (Region Sjælland)

        Exclusion Criteria:

          -  Known allergy to bupivacaine or other local anesthetics of amide-type

          -  Declared incapable of making his/hers own affairs

          -  Does not comprehend Danish in the written or spoken language

          -  Cognitive impairment to a degree influencing the testing reliability

          -  Known recurrence of the inguinal hernia

          -  Other surgical procedures performed in the groin or on the external genitals

          -  Neuropathy affecting the groin region caused by other conditions, e.g. post-stroke,
             multiple sclerosis, herniated intervertebral disc

          -  Abuse of alcohol or drugs

          -  Unable to cooperate with the sensory examinations
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: tDCS and Sex Differences (NCT04471805)

Eligibility criteria:
Inclusion Criteria:

          1. Has a regular menstrual cycle (for women only)

          2. Young adult (18-35 years)

          3. Right-side dominant

          4. At least 30 min of moderate-intensity, physical activity on at least 3 days of the
             week for at least the last 3 months

          5. Without chronic neurological, psychiatric, or medical conditions

          6. Not taking any psychoactive medications.

        Exclusion Criteria:

          1. Pregnant

          2. Known holes or fissures in the skull

          3. Metallic objects or implanted devices in the skull (e.g., metal plate)

          4. Women on hormonal contraceptives/supplements.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Trial to Compare Prophylaxis Therapy to On-demand Therapy With a New Full Length Recombinant FVIII in Patients With Severe Hemophilia A (NCT01233258)

Eligibility criteria:
Inclusion Criteria:

          -  Male, aged 12 to 65 years

          -  Severe hemophilia A

          -  History of more than 150 exposure days (ED) with clotting factor concentrates

          -  Currently receiving episodic treatment with FVIII; no regular prophylaxis for more
             than 6 consecutive months in the past 5 years

          -  No current Factor VIII inhibitor or history of inhibitor

          -  Willing to use electronic patient diary

        Exclusion Criteria:

          -  Presence of another bleeding disease that is different from hemophilia A

          -  Thrombocytopenia

          -  Abnormal renal function

          -  Presence of active liver disease

          -  Known hypersensitivity to FVIII
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: International Study on Syncope of Uncertain Etiology (NCT00120094)

Eligibility criteria:
Inclusion Criteria:

          -  Suspected or certain neurally-mediated syncope, based on the Guidelines of the ESC TF
             on Syncope.

          -  3 syncope episodes in the last 2 years.

          -  Severe clinical presentation of syncope requiring treatment initiation in the
             judgement of the investigator.

          -  Age >30 years.

          -  Patients have undergone carotid sinus massage, and ILR implantation.

        Exclusion Criteria:

          -  ILR not implanted for any reason; in this case, the patients are still followed in the
             ILR-not implanted group.

          -  Carotid sinus syndrome.

          -  Suspected or certain cardiac syncope.

          -  Symptomatic orthostatic hypotension diagnosed by standing blood pressure measurement.

          -  Loss of consciousness different from syncope (e.g. epilepsy, psychiatric, metabolic,
             drop-attack, TIA, intoxication, cataplexy).

          -  Steal syndrome.

          -  Psychologically or physically (due to any other illness) unfit for participation in
             the study according to the opinion of the investigator.

          -  Patient compliance doubtful.

          -  Patients who are geographically or otherwise inaccessible for follow-up.

          -  Patient unwilling or unable to give informed consent;

          -  Pregnancy.

          -  Life expectancy < 1 year due to non-cardiac cause
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Contradiction
Clinical trial: Dexibuprofen 400 mg Sachet Versus Ibuprofen 400 mg Sachet in Patients With Osteoarthritis of the Hip or Knee (NCT01066676)

Eligibility criteria:
Inclusion Criteria:

          -  male or female patients aged between 18 and 75 years

          -  everyday joint pain for the past three months

          -  global pain intensity in the involved joint (hip or knee) of "moderate" to "severe"
             within the last 48 h

        Exclusion Criteria:

          -  acute inflammation or ischaemic necrosis

          -  paget's disease, chondrocalcinosis, ochronosis of the hip/knee joint

          -  slowly progressing hip/knee arthropathy in particular of tuberculosis aetiology

          -  hip/knee arthropathy due to diabetes mellitus

          -  Charcot's joint

          -  villous synovitis

          -  chondromatosis of the synovium

          -  patients with existing gastritis or existing ulcers or bleedings in the
             gastrointestinal tract or patients with history of gastrointestinal ulcers or
             gastrointestinal haemorrhage in the past 6 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Atlas Predicted DBS Settings in Essential Tremor (NCT02678429)

Eligibility criteria:
Inclusion Criteria:

        Seleced for DBS of the VIM nucleus at Vanderbilt Medical center Diagnosis of essential
        tremor

        Exclusion Criteria:

        Unable to use the patient handheld programmer
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Six Months DHEA Treatment in Female Adrenal Failure (NCT00471900)

Eligibility criteria:
Inclusion Criteria:

          -  Female,

          -  Adrenal insuficiency,

          -  Stable and safe anticonception,

          -  Stable hydrocortison substituation treatment.

        Exclusion Criteria:

          -  Neoplastic and thromboembolic disease,

          -  Diabetes mellitus.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Entailment