araag2/NLI4PR huggingface dataset:
Clinical trial: The Effect of Systemic Lidocaine Infusion to Postoperative Pain and Quality of Recovery After Laparoscopic Hernia Repair in Children (NCT02007330)

Eligibility criteria:
Inclusion Criteria:

          -  Age between 1 and 6 year-old

          -  ASA class 1 and 2

          -  Pediatric Inguinal hernia patients who are scheduled for elective laparoscopic
             inguinal hernia repair

        Exclusion Criteria:

          -  Allergy to local anesthetics or contraindication to use of lidocaine

          -  Current active upper respiratory infection or history of upper respiratory infection
             within 2 weeks

          -  Severe cardiovascular disease

          -  Renal failure

          -  Liver failure

          -  Neurologic and psychologic disease

          -  Chronic treatment with analgesics

          -  Previous history of laparoscopic operation

          -  Parents' refusal
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 6 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Trial Investigating Safety and Efficacy of Treatment With BAY94-9027 in Severe Hemophilia A (NCT01580293)

Eligibility criteria:
Inclusion Criteria:

          -  Male; 12-65 years of age

          -  Subjects with severe hemophilia A

          -  Previously treated with factor VIII for a minimum of 150 exposure days

        Exclusion Criteria:

          -  Inhibitors to FVIII (current evidence or history)

          -  Any other inherited or acquired bleeding disorder in addition to Hemophilia A

          -  Platelet count < 100,000/mm3

          -  Creatinine > 2x upper limit of normal or AST/ALT (aspartate aminotransferase/alanine
             aminotransferase) > 5x upper limit of normal
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: The Liver in the World Trade Center Health Program General Responder Cohort and Controls (NCT03858920)

Eligibility criteria:
Inclusion Criteria:

          -  Male or Female between 55 and 80 years of age

          -  30 year pack-history of smoking and are either current smokers or who quit during the
             past 15 years.

          -  Individuals who are members of the World Trade Center General Responder Cohort or
             Subjects who meet the United States Preventive Services Task Forces guidelines for
             lung cancer screening

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 55 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Menstrual Cycle Characteristics of Healthcare Professionals (NCT04413058)

Eligibility criteria:
Inclusion Criteria:

          -  Working at Covid 19 Pandemic Hospital

          -  Being at between 18 and 47 years old

          -  Having menstruation

        Exclusion Criteria:

          -  Oral contraceptive users

          -  Pregnants

          -  Having malignancy

          -  Having primary amenorrhea

          -  Being at menopause

          -  Lactation
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 47 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? Entailment
Clinical trial: The Nitrate and Bone Study: Effects of Nitrates on Osteoporosis (NCT00252421)

Eligibility criteria:
Inclusion Criteria:

          -  Women aged 50 and older

          -  Lumbar spine BMD (L1 to L4) T score between 0 and -2.0

          -  At least 3 years postmenopausal

        Exclusion Criteria:

          -  Prior low trauma hip or vertebral fracture

          -  Total hip or femoral neck T score of <-2.0

          -  Bone disorders other than osteopenia (e.g., hyperparathyroidism or Paget's disease)

          -  Treatment within six months of study entry with androgen, calcitonin, estrogen,
             progesterone, fluoride in a tablet form, raloxifene, tamoxifen, etidronate, prednisone
             or an equivalent at 5 mg/d for 12 months or greater, lithium or anticonvulsants

          -  Alendronate or risedronate use for at least four weeks, within the last three years

          -  Current treatment with nitrates

          -  Systolic blood pressure of =<100 mm Hg or diastolic blood pressure >=100 mm Hg at the
             baseline screening examination

          -  Abnormal electrocardiogram (ECG) at the baseline screening examination

          -  history of myocardial infarction, angina, valvular or congenital heart disease

          -  Disabling conditions that may interfere with follow-up visits

          -  Inability to give informed consent

          -  Migraine headaches

          -  Hypersensitivity to nitrates
Female
Accepts Healthy Volunteers
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Digital Intervention for HIV Prevention in Black Adolescent Girls (NCT04108988)

Eligibility criteria:
Inclusion Criteria:

        Both phases (includes focus groups- Phase 1)

          -  Black (race)

          -  Heterosexual

          -  Currently enrolled in high school

        Pilot Test (Phase 2)

          -  Ability to participate in web-based videogame

          -  Willing to sit for at least 60 minutes (to play the game)

          -  No HIV testing in the last 12 months

          -  Ability to provide assent or parental/guardian consent

        Exclusion Criteria:

          -  Failure to meet inclusion criteria
Female
Accepts Healthy Volunteers
Subject must be at least 14 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Elastography as Gouty Arthropathy Outcome (EGO) (NCT02471261)

Eligibility criteria:
Inclusion Criteria:

          1. Subjects who are at least 18 years of age but younger than or equal to 99 years of
             age.

          2. Subjects with gouty arthritis as determined by the ACR 1977 classification criteria
             for gouty arthritis.

          3. Subjects with one palpable tophus detectable by one of the three clinical parameters
             described.

             -

        Exclusion Criteria:

          1. Subjects who are not eligible for urate lowering treatment or show a hypersensitivity
             to these drugs or class of compounds.

          2. Subjects with significant cardiovascular, neuropsychiatric, hematologic, hepatic,
             renal or endocrine dysfunction who in the opinion of the principal investigator are
             unfit for participation in a clinical trial.

          3. Subjects for which the clinical and laboratory assessment would provide undue
             discomfort and / or are contraindicated.

             -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Risk Stratification in Children and Adolescents With Primary Cardiomyopathy (NCT03572569)

Eligibility criteria:
Inclusion Criteria:

          1. Index patients:

               -  Age ≤18 years

               -  written informed consent of parents/legal guardians

               -  diagnosis of primary cardiomypathy:

               -  DCM: left ventricular (LV) systolic dysfunction and dilatation greater than two
                  standard deviations (SD) above the mean of a normal population

               -  HCM: LV hypertrophy and septal wall thickness above two SD

               -  RCM: diastolic dysfunction and concordant atrial enlargement

               -  LVNC: separation of the myocardium into a compacted (C) and a non- compacted (NC)
                  layer with an NC/C ratio >2 in echocardiography and/or >2.3 in CMR

               -  ARVC: according to the revised Task Force Criteria

          2. First-degree family members (parents and siblings):

               -  Age ≥3 years

               -  written informed consent of parents/legal guardians and siblings ≥18 years

        Exclusion Criteria:

          -  unwillingness to give consent

          -  myocardial inflammation / myocarditis

          -  systemic disease with cardiac involvement (secondary cardiomyopathy)

          -  structural congenital heart disease
No condition on gender to be admitted to the trial.


Subject must be at most 18 Years

Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Contradiction
Clinical trial: To Assess the Efficacy of CitruSlim® on Body Composition as Well as Metabolic and Hormonal Factors in Overweight and Obese Individuals (NCT03973086)

Eligibility criteria:
Inclusion Criteria:

          1. Male and female participants with the age of ≥18 and ≤ 60 years of age.

          2. BMI of ≥25 - ≤ 35 kg/m2

          3. Waist circumference:India: Men: > 94 cm (37 inches), Women: >80 cm (31.5 inches) USA:
             Men: > 102 cm (40 inches), Women: >89 cm (35 inches)

          4. Triglycerides >150 mg/dL

          5. Blood pressure: Systolic: ≥130 mm Hg and/or Diastolic: ≥85 mm Hg

          6. Fasting blood glucose ≥ 100 mg/ dl

          7. Low HDL level: Men: < 40 mg/dL, Women: < 50 mg/dL

          8. Ready to give voluntary, written, informed consent to participate in the study.

        Exclusion Criteria:

        Participants meeting any of the following criteria will be excluded from the trial:

          1. Current smoker.

          2. Inability to walk independently.

          3. Presence of unstable, acutely symptomatic, or life-limiting illness.

          4. Neurological conditions causing functional or cognitive impairments

          5. Unwillingness or inability to be randomized to one of three intervention groups.

          6. Bilateral hip replacements.

          7. Exposure to any non-registered drug product within 3 months prior to the screening
             visit.

          8. Unable/unwillingness to complete study specific diaries (digital/paper-based).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction