araag2/NLI4PR huggingface dataset:
Clinical trial: Safety/Efficacy Study to Assess Whether FVIII/VWF Concentrate Can Induce Immune Tolerance in Haemophilia A Patients (NCT02479087)

Eligibility criteria:
Inclusion Criteria:

          1. Subjects (his/her parent/legal representative), must have given a written informed
             consent.

          2. Male children: age <12 years.

          3. Severe or moderate Haemophilia A (FVIII <2%).

          4. High responders (clinical history of inhibitor peak > 5BU) or low-responders (clinical
             history of inhibitor peak < 5 BU) with potential bleedings, assessed by responsible
             physicians as not to be treated with high FVIII doses.

          5. Any level of inhibitor at study enrollment.

          6. Willingness and ability to participate in the study.

          7. No other experimental treatments (involving or not FVIII concentrates).

        Exclusion Criteria:

          1. Any clinically relevant abnormality, in hematological, biochemical and urinary routine
             examinations, or any condition or treatment which in the investigator's opinion, makes
             the patient not eligible for the study.

          2. Intolerance to active substances or to any of the excipients of FVIII / VWF
             concentrates.

          3. Concomitant systemic treatment with immunosuppressive drugs.
Male
No healthy subjects accepted to join the trial.

Subject must be at most 12 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Efficacy of Using Far Infrared Radiation to Manage Muscular Dystrophies (NCT00674843)

Eligibility criteria:
Inclusion Criteria:

          -  Persons with muscular dystrophies

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of Zenker's Diverticulum Treatment Using Peroral Endoscopic Myotomy and Flexible Endoscopy Septotomy. (NCT04514042)

Eligibility criteria:
Inclusion Criteria:

          1. Males and females who are 18 years of age and older and are able to comprehend
             instructions and follow the study procedures and are willing to sign an Informed
             Consent Form (ICF).

          2. Patients with symptomatic Zenker's Diverticulum.

          3. Confirmed diagnosis of Zenker's Diverticulum based on endoscopic and radiological
             examinations.

          4. Size of Zenker's Diverticulum in the range of 1,5 to 4 cm on radiological
             examinations.

        Exclusion Criteria:

          1. Lack of written consent for participation in the study.

          2. Size of Zenker's Diverticulum <1,5 cm or >4 cm on radiological examination.

          3. Active cancer.

          4. Esophageal stricture.

          5. Eosinophilic esophagitis (EoE).

          6. Pre-cancerous changes in the esophagus.

          7. Previous surgical or endoscopic treatment of Zenker's Diverticulum.

          8. Presence of chewing deficiencies and/or neurogenic dysphagia.

          9. Presence of other esophageal motility disorders e.g. achalasia and/or spastic motility
             disorders.

         10. Severe systemic diseases which are contraindication to general sedation.

         11. Severe coagulopathy.

         12. Pregnancy and breastfeeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? Entailment
Clinical trial: The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis (NCT01282164)

Eligibility criteria:
Inclusion Criteria:

          -  18 to 80 years of age

          -  male and female

          -  hypothalamic pituitary disorders (study subjects)

          -  history of regular, age appropriate menses (control subjects)

          -  male subjects with normal serum testosterone and follicle stimulating hormone (FSH)
             (control subjects)

          -  normal FSH in post-menopausal subjects (control subjects)

          -  normal thyroid stimulating hormone (TSH), free thyroxine (T4), prolactin (control
             subjects)

        Exclusion Criteria:

          -  unable to give consent

          -  pregnancy

          -  active acromegaly

          -  pheochromocytoma

          -  active Cushing's disease

          -  pituitary insult within past 6 weeks

          -  elevated alanine aminotransferase (ALT) or aspartate aminotransferase (AST)

          -  renal failure

          -  history of malignancy

          -  severe acute illness

          -  uncontrolled hypertension

          -  Diabetes mellitus (DM) type 1

          -  Hemoglobin (Hgb) A1c >9% in last 3 months in Type 2 DM

          -  severe coronary artery disease

          -  women <50 years of age with untreated hypogonadism

          -  men with untreated hypogonadism

          -  growth hormone treatment in the past 3 months
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Entailment
Clinical trial: Use of Parietex Plug and Patch Hernia System in Open Inguinal Hernia Repair (NCT01590940)

Eligibility criteria:
Inclusion Criteria:

          -  All patients regardless of gender > 18 years of age presenting with inguinal hernias.

          -  Subjects will be informed of the nature of the study, and have provided signed written
             consent.

        Exclusion Criteria:

          -  children under the age of 18

          -  subjects that meet criteria for biologic mesh placement

          -  emergency procedure

          -  recurrent hernias.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Contradiction
Clinical trial: LifeZig Personalized Reminiscence Video With Slideshows and Music for Individuals With Alzheimer's and Dementia (NCT00759863)

Eligibility criteria:
Inclusion Criteria:

          -  Inclusion criteria for dementia patients:

               -  documented diagnosis of probable Alzheimer's or other type of dementia, medically
                  stable, and visual/hearing capabilities to watch television.

          -  Inclusion criteria for family members/caregivers:

               -  provide care or be a family member of dementia patient, have knowledge of the
                  person, and be able to provide old photographs of dementia patient.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Nutrition Education Module for Preschooler Children (NCT03910257)

Eligibility criteria:
Inclusion Criteria:

          -  children registered in selected public kindergarten

          -  grade/class B kindergarten

          -  willing to follow the study

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 7 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Entailment
Clinical trial: Face Anthropometric Pattern Recognition Technology for Computer Aided Diagnosis of Human Genetic Disorders. (NCT00705055)

Eligibility criteria:
Inclusion Criteria:

          -  all newborn infants born at the Carmel Medical Center following parental consent, and
             at Soroka Medical Center.

        Exclusion Criteria:

          -  No parental consent; Facial deformation not related to chromosomal or genetic
             anomalies; babies transferred to the neonatal intensive care unit that need
             ventilatory support.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers

Subject must be at most 2 Weeks

Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? Contradiction
Clinical trial: Multicentre Study Comparing Indwelling Pleural Catheter With Talc Pleurodesis for Malignant Pleural Effusion Management (NCT02045121)

Eligibility criteria:
Inclusion Criteria:

          -  Symptomatic malignant pleural effusion requiring intervention

        Exclusion Criteria:

          -  <18 years of age

          -  pregnant or lactating patients

          -  expected survival <3 months

          -  chylothorax

          -  previous attempted pleurodesis

          -  pleural infection

          -  leukocytopaenia (<1.0 x 10^9/L)

          -  uncorrectable bleeding diathesis

          -  inability to give informed consent or comply with the protocol
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain (NCT00418782)

Eligibility criteria:
Inclusion Criteria:

          -  Is a healthy adult 18 to 75 years of age, inclusive, in general good health and with
             diagnosis of knee OA, as determined by the American College of Rheumatology (ACR)
             clinical/radiographic classification criteria for OA of the knee.

          -  Women must be of non childbearing potential (amenorrhea for at least 1 year PLUS have
             a serum follicle stimulating hormone (FSH) level >30 IU/L, bilateral oophorectomy or
             hysterectomy), and have a confirmed negative serum pregnancy test at the screening
             visit prior to randomization.

        Exclusion Criteria:

          -  History of other diseases that may involve the study joint, including inflammatory
             joint diseases, crystalline disease, endocrinopathies, metabolic diseases, infections,
             neuropathic disorders, avascular necrosis, Paget's disease, or tumors.

          -  Women of childbearing potential, or who are pregnant or lactating.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment