araag2/NLI4PR huggingface dataset:
Clinical trial: Physical Endometrial Manipulation and Its Effect on ICSI (NCT03345251)

Eligibility criteria:
Inclusion Criteria:

          -  Infertile female age 20-35 years

          -  Previous Failed one ICSI trial

          -  normal basal hormonal profile [FSH, LH] 3-10 mIU/ml and 1.8-8.5 mIU/ml respectively,
             --normal endometrial cavity

          -  patent tubes

          -  normal Husband semen analysis

        Exclusion Criteria:

          -  Ovarian factor of infertility

          -  Tubal factor of infertility

          -  Endometrial factor of infertility

          -  Male factor of infertility
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: Cognitive Training for Fragile X Syndrome (NCT02747394)

Eligibility criteria:
Inclusion Criteria:

          -  fragile X full mutation

          -  normal or corrected vision

          -  English or Spanish speaking

          -  ability to pass three-span items following completion of a Cogmed training session at
             baseline

          -  parental agreement to maintain adherence to the training schedule and to not alter
             other treatments during the study unless medically necessary

        Exclusion Criteria:

          -  previous Cogmed training

          -  significant medical problems that would interfere with the study or significant brain
             trauma
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Alzheimer's Disease Treatment and Illness Perceptions Survey (TIPS) II (NCT00059410)

Eligibility criteria:
Inclusion Criteria:

        Three groups of participants are sought to take part in the survey:

          -  70 primary caregivers(current or former) of persons with AD, or related memory
             disorders

          -  70 adult children and siblings of people with AD or related memory disorders

          -  70 adults age 40 and older without immediate family history of AD or related memory
             disorders

        Exclusion Criteria:

          -  Not fluent in English

          -  Cognitive impairment that would preclude responding to a 30-minute telephone survey
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Nutrition Support for Hirschsprung Disease (NCT04598841)

Eligibility criteria:
Inclusion Criteria:

          1. Children aged 0-2 years.

          2. Clinical diagnosis with Hirschsprung's disease who requires surgery;

        Exclusion Criteria:

          1. Complicated with severe complications such as enterocolitis associated with
             Hirschsprung disease;

          2. History of diseases associated with various organ systems that may be
             life-threatening;

          3. Other severe digestive tract malformations or other diseases that may interfere with
             the treatment or compliance of the child;

          4. Patients who have participated in other clinical trials within the last 1 month;

          5. Any other conditions in which the investigator considers it inappropriate to
             participate in the trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 2 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Entailment
Clinical trial: Diagnostic Evaluation of Patients With Neuromuscular Disease (NCT00015470)

Eligibility criteria:
-  INCLUSION CRITERIA:

        Research patients will be studied under this protocol if they fulfill the following
        criteria:

        Have an identifiable neuromuscular disorder that may be suitable for a specific current or
        future protocol;

        Present a diagnostic puzzle in spite of the previously performed diagnostic work-up;

        Have unusual manifestation of a more usual neuromuscular disease;

        Have a disorder useful for teaching purposes.

        Patients should be referred by a physician who will continue their care after our
        evaluation. A report of the patients' visit and tests, along with suggestions or
        recommendations will be sent to each referring physician. There is a wide spectrum of
        neuromuscular diseases to be studied, among them are: peripheral neuropathies, myopathies,
        dystrophies, myasthenia, stiff person syndrome, muscle cramps, myotonias, motor neuron
        diseases, post-polio syndrome, and certain demyelinating disorders affecting both the
        central and the peripheral nervous system.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Transcriptomic Profile of Endometrium in Different Histological Dating of Natural Cycle (NCT03222830)

Eligibility criteria:
Inclusion Criteria:

          -  The inclusion criteria for RIF group were: unexplained repeated implantation failure
             (RIF) is defined as the absence of a gestational sac on ultrasound at 5 or more weeks
             after embryo transfer (ET) after 3 embryo transfers with high quality embryos or after
             the transfer of ≥10 embryos in multiple transfers.

        The inclusion criteria for control group were: (1) age <35 years; (2) regular menstrual
        cycles of 24-35 days; (3) baseline follicle- stimulating hormone (FSH) < 9.0 IU/L; (4)
        endometrial thickness ≥8.0 mm on the day of hCG administration.

        Exclusion Criteria:

          -  (1) uterine abnormalities (double uterus, bicornuate uterus, unicornuate uterus); (2)
             intrauterine adhesions（moderate - severe）, endometriosis, adenomyosis, untreated
             hydrosalpinx, uterine fibroids (submucosal fibroids, nonmucosal fibroids >4.0 cm
             and/or endometrial pressure) (3) history of adverse pregnancy (including spontaneous
             abortion, stillbirth, and fetal malformation).
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Response of Children With Atopic Dermatitis (Eczema) to Eucrisa (NCT04023084)

Eligibility criteria:
Inclusion Criteria:

          -  AD diagnosis by dermatologist or allergist based on Hanifin and Rajka criteria

          -  5% or more treatable body surface area involvement

          -  baseline Investigator's Static Assessment (ISGA) score of mild (2) or moderate (3)

          -  patient on stable regimens (consistent use 14 days before day 1 of enrollment) of
             inhaled corticosteroids and antihistamines

          -  must have lesional skin in the antecubital fossa

        Exclusion Criteria:

          -  use of topical corticosteroid, calcineurin inhibitor, or PDE4 inhibitor within 14 days
             of enrollment

          -  significant active infection

          -  any previous use of biologic therapy

          -  no pruritus at baseline visit, or other pruritic condition

          -  washing/moisturizer use 24 hours prior to tape strip biomarker collection at site

          -  uncontrolled asthma, uncontrolled allergic rhinitis, or other sleep disturbing
             condition
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient description (patient's own words): I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Does the patient match the trial criteria? Entailment
Clinical trial: Mutation Exploration in Non-acquired, Genetic Disorders and Its Impact on Health Economy and Life Quality (NCT02380729)

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis: Suspicion of genetic disease. (Only one of the following criteria is
             required.) [1.1] Family member(s) with similar phenotype OR [1.2] At least two
             affected organ systems OR [1.3] One affected organ system that is known to be
             associated with multiple disease causing genes (e.g. long QT syndrome) OR [1.4]
             Multiple birth defects

          2. Both parents must be available for blood draw in order to confirm phase (segregation
             analysis) or in order to perform WGS of the trio at a later time point.

          3. Age: from birth up until age 18 years

          4. Gender: Both sexes will be included

        Exclusion Criteria:

          1. Suspicion that the phenotype is due to an acquired disease

          2. Missing informed consent from both parents or from all legal guardians for genetic
             testing in the setting of a clinical trial.

          3. Clinical diagnosis of a disease with a known monogenic cause, e.g. Phenylketonuria or
             Cystic fibrosis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Entailment
Clinical trial: Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile Men (NCT04675164)

Eligibility criteria:
Inclusion Criteria:

          -  Eligible couples are those undergoing ICSI due to azoospermia with testicular biopsy
             positive for sperm (either fresh or cryopreserved) following testicular sperm
             extraction (TESE) or aspiration (TESA).

        Exclusion Criteria:

          -  Cases with female factor infertility or woman age above 35 years will be excluded.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Entailment