araag2/NLI4PR huggingface dataset:
Clinical trial: Evaluation of Prealbumin Levels in Men With Low-T (NCT03313635)

Eligibility criteria:
Inclusion Criteria:

          -  Provide responses to standard questionnaires administered to subjects

          -  Written Informed Consent obtained

          -  Male sex at birth

          -  ≥ 40 and ≤ 75 years of age

          -  Presentation to the clinic with symptoms suggestive of low testosterone such as loss
             of libido, erectile dysfunction, cognitive or mood disturbances, etc.

          -  Able and willing to provide blood specimens and follow study schedule

          -  A final diagnosis can be established (androgen deficient versus not androgen
             deficient)

        Exclusion Criteria:

          -  Previous exposure to exogenous T, DHEA, clomiphen citrate, or other Selective Estrogen
             Receptor Modulators, or OTC or herbals (Treatment Naïve)

          -  Use of opioid medication within 3 months prior to enrollment

          -  Serious psychiatric disease or uncontrolled medical illness, as suspected from medical
             history or clinical examination

          -  Use of any sex hormones or steroidal anabolic drug supplements (OTC or
             prescribed)(Treatment Naïve)

          -  Incapable of giving informed consent or complying with protocol or unwilling to comply
             with protocol requirements

          -  Diagnosis of prolactinoma
Male

Subject must be at least 40 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluation of 24-Hour Intragastric pH Using Esomeprazole, Lansoprazole, and Pantoprazole in Hispanic Patients With GERD (NCT00410592)

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent

          -  Males and females ages 18-69 who are of Hispanic origin

          -  Symptoms of GERD, defined as heartburn at least 2 times a week on average over the
             last 3 months

        Exclusion Criteria:

          -  Female patients who are pregnant or breastfeeding

          -  Known intolerance or lack of response to Proton Pump Inhibitors (PPIs) such as Nexium,
             Prevacid, or Protonix

          -  Current or relevant history of non-healed ulcers, stomach surgery, or esophageal
             surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 69 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Study Evaluating "Real World" Treatment Pattern in Previously Treated Hemophilia A Patients Receiving KOVALTRY (Octocog Alfa) for Routine Prophylaxis (NCT02830477)

Eligibility criteria:
Inclusion Criteria:

          -  Male patients diagnosed with moderate to severe hemophilia A (≤ 5% FVIII:C (Factor
             VIII Coagulant activity))

          -  Any age

          -  ≥ 50 exposure days (EDs) to any FVIII product

          -  Patients with or without history of inhibitors

               -  Patient with previous history of inhibitors, with at least 2 consecutive negative
                  inhibitor tests and on standard prophylaxis therapy for at least 1 year prior to
                  study entry

               -  No current evidence of FVIII inhibitor or clinical suspicion of FVIII inhibitor

                    -  Evidence of FVIII inhibitor as measured by the Nijmegen-modified Bethesda
                       assay [<0.6 Bethesda units (BU/mL)] or Bethesda assay [< 1.0 BU/mL] in 2 on
                       consecutives samples

                    -  Documented or clinical suspicion of shortened FVIII half-life (< 6 hrs)

          -  Currently on or plan to start prophylaxis therapy with KOVALTRY

          -  Written informed consent

        Exclusion Criteria:

          -  Patients participating in an investigational program with interventions outside of
             routine clinical practice

          -  Patients with an additional diagnosis of any bleeding/coagulation disorder other than
             hemophilia A

          -  Patients on Immune Tolerance Induction (ITI) treatment at the time of enrollment
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Norwegian Adenomyosis Study III: Peristalsis (NCT02197936)

Eligibility criteria:
Inclusion Criteria:

          -  Premenopausal women aged 20-45 years having been diagnosed with adenomyosis earlier
             and have no other pathology of the uterus, regardless of clinical symptoms.

        Exclusion Criteria:

          -  Postmenopausal women,

          -  Pregnant women,

          -  Gynaecological cancer,

          -  GnRH analog therapy or systemic hormone therapy in the last three months prior to
             hysterectomy,

          -  Endometriosis,

          -  Uterine fibroids
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Study to Establish Bioequivalence of ReFacto AF (BDDrFVIII) With Advate (FLrFVIII) in Hemophilia A (NCT00141843)

Eligibility criteria:
Inclusion Criteria:

          -  Male subjects with severe or moderately severe hemophilia A

          -  A negative past medical history of a Factor VIII inhibitor

          -  Age greater than or equal to 12 years

        Exclusion Criteria:

          -  A history of Factor VIII inhibitors

          -  Presence of a bleeding disorder in addition to hemophilia

          -  Known hypersensitivity to hamster protein
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: The Safety and Efficacy of Fibrinolysis in Patients With an Indwelling Pleural Catheter for Multi-loculated Malignant Pleural Effusion. (NCT03678090)

Eligibility criteria:
Inclusion Criteria:

          -  Malignant Pleural Effusion MPE (either cytology proven or recurrent exudative pleural
             effusion in the context of histologically proven cancer)

          -  Presence of an indwelling pleural catheter (IPC)

          -  Nondraining IPC (defined as <50 mL of drainage on the past three drainage attempts)
             not responding to routine saline flush to assure patency

          -  Residual pleural fluid remaining on chest x-ray (CXR) or ultrasound

          -  Dyspnea deemed attributable to the effusion (i.e. symptomatic loculations), as
             assessed by the treating chest physician and using the modified Borg scale

          -  Presence of written informed consent from the patient or surrogate

        Exclusion Criteria:

          -  Age <18

          -  Expected survival less than 14 days

          -  Known allergy or intolerance to tissue plasminogen activator
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Entailment
Clinical trial: Cross-linked Hyaluronic Acid and Coenzyme Q10 in the Treatment of Dry Eye (NCT03074344)

Eligibility criteria:
Inclusion Criteria:

          -  age between 18 and 80 years,

          -  history of at least 3 months of dry eye symptoms referable to mild to moderate dry
             eye.

        Exclusion Criteria:

          -  presence of any ocular disease, present or past, other than dry eye;

          -  previous ocular surgery,

          -  use of contact lens or topic treatments other than tear substitutes;

          -  presence of systemic diseases requiring a treatment with systemic drugs potentially
             interfering with tear productions;

          -  hypersensitivity to the active substance or to excipients;

          -  participation in a clinical trial during the 3 months prior to the beginning of the
             study,

          -  pregnancy or breast-feeding.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? Contradiction
Clinical trial: Risk and Resilience Factors in Learning Disabilities Population (NCT01652651)

Eligibility criteria:
Inclusion Criteria:

          -  Learning Disorder diagnosis

          -  Normal range IQ

          -  Regular class attendance

        Exclusion Criteria:

          -  Suicidal ideation and psychosis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 11 Years old.
Subject must be at most 15 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? Entailment
Clinical trial: Treatment of Oral Erosive Lichen Planus With Pimecrolimus Cream (NCT00321750)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmation of the diagnosis of OELP by histological examination and a clinical score
             superior to 3

        Exclusion Criteria:

          -  Patients under 18 years

          -  Pregnancy or breast feeding

          -  Malignancy

          -  Severe or recurrent infections

          -  Uncontrolled chronic disorders

          -  Congenital or acquired immunosuppression and concomitant treatments potentially
             effective on OELP such as antimalarials, oral retinoids, steroids or immunosuppressive
             drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: Evaluating Color Perception Under LED Red/Green and Green Dominant Light (NCT01927536)

Eligibility criteria:
Inclusion Criteria:

          -  normal vision

          -  18-65 years

        Exclusion Criteria:

          -  blindness

          -  colorblind

          -  pregnant women

          -  prisoners

          -  decisionally challenged
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 66 Years

Patient description (medical language): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient description (patient's own words): I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Does the patient match the trial criteria? Contradiction