araag2/NLI4PR huggingface dataset:
Clinical trial: Management of Adrenal Emergency in Germany (NCT03426332)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥18 years

          -  Documented chronic adrenal insufficiency

          -  Established corticosteroid replacement therapy

          -  Written informed consent

        Exclusion Criteria:

        - Age <18 years
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? Contradiction
Clinical trial: PTG-300 in Subjects With Hereditary Hemochromatosis (NCT04202965)

Eligibility criteria:
Inclusion Criteria:

          -  Men and women aged 18 and older

          -  Confirmed diagnosis of HFE-related hereditary hemochromatosis with prior genotype
             testing

          -  Documented stable phlebotomy for ≥ 6 months

          -  Screening hemoglobin >11.5 g/dL

          -  Documented evidence of prior serum ferritin ≥500 ng/mL

          -  Serum ferritin >50 ng/mL and <300 ng/mL at screening

        Exclusion Criteria:

          -  Clinically meaningful laboratory abnormality

          -  Receiving iron chelation therapy

          -  Receiving erythrocytapheresis

          -  Pregnant or lactating females

          -  Infection requiring hospitalization or intravenous antimicrobial therapy, or
             opportunistic infection within 3 months of dosing; any infections requiring
             antimicrobial therapy within 4 weeks of dosing.

          -  Serious or unstable medical or psychiatric condition that would prevent subject
             providing informed consent

          -  Organ damage from iron overload

          -  Primary or secondary immunodeficiency

          -  Positive hepatitis B or hepatitis C or known human immunodeficiency virus infection

          -  Known history of autoimmune/inflammatory diseases

          -  Any surgical procedures requiring general anesthesia within 1 month prior to screening
             or planned surgery during study

          -  History of invasive malignancies within last 2 years, except non-malignant skin cancer
             and local cured prostrate cancer, cervical cancer, or ductal carcinoma in situ

          -  Receipt of an investigational agent within 30 days of screening
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Entailment
Clinical trial: Pharmacokinetics and Safety of rFVIIIFc Manufactured at 15,000 L (15K) Scale (NCT02502149)

Eligibility criteria:
Key Inclusion Criteria:

          -  Have severe hemophilia A, defined as <1 IU/dL (<1%) endogenous FVIII as determined by
             one-stage clotting assay from the central laboratory at Screening.

          -  Previously treated subject, defined as having at least 150 documented prior exposure
             days (EDs) to any recombinant and/or plasma-derived FVIII and/or cryoprecipitate
             products at Day 1. Fresh frozen plasma treatment must not be considered in the count
             for documented exposure days.

          -  No history of a positive inhibitor test or clinical signs of decreased response to
             FVIII administrations. Family history of inhibitors will not exclude the subject.

          -  No measurable inhibitor activity using the Nijmegen-modified Bethesda assay (>=0.6
             Bethesda Unit per milliliter [BU/mL] is considered positive) at Screening.

        Key Exclusion Criteria:

          -  Current enrollment in any interventional clinical study in which an investigational
             drug or approved therapy for investigational use is administered within 30 days prior
             to the Baseline Visit OR prior participation in any of the following Biogen studies:
             998HA101 (NCT01027377), 997HA301 (NCT01181128), 8HA02PED (NCT01458106), 997HA307
             (NCT02083965), and 8HA01EXT (NCT01454739).

          -  Previous participation in this study.

          -  Any concurrent clinically significant major disease that, in the opinion of the
             Investigator or Biogen, makes the subject unsuitable for participation in the study.

          -  Other coagulation disorder(s) in addition to hemophilia A.

          -  History of hypersensitivity or anaphylaxis associated with FVIII or intravenous (IV)
             immunoglobulin administration.

        NOTE: Other protocol-defined inclusion/exclusion criteria may apply.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients (NCT03497728)

Eligibility criteria:
Inclusion Criteria:

        -Male patients diagnosed with azoospermia and severe oligozoospermia.

        Exclusion Criteria:

          1. Klinefelter Syndrome ;

          2. Structural chromosome aberrations；

          3. Obstructive anspermia;

          4. Male infertility caused by endocrine factors;

          5. Do not meet requirements for acquisition, processing and preservation of samples；

          6. After sampling, it doesn't conform to the standard of quality control, or other
             experimental conditions that don't meet the test requirement；

          7. Unable to obtain patient history;
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? Contradiction
Clinical trial: Transcranial Direct Current Stimulation (tDCS) as a Cognitive Enhancer for Patients With Alzheimers Disease (NCT02518412)

Eligibility criteria:
Inclusion Criteria:

          -  Alzheimers disease according to (National Institute of Neurological and Communicative
             Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association).

          -  The cognitive impairment and decline must be documented by cognitive /
             neuropsychological testing and from an informant.

        Exclusion Criteria:

          -  Stroke,

          -  Cancer,

          -  Psychiatric disorders (major depression, psychosis) or diseases / injuries in the
             central nervous system.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Alzheimer Disease : Rehabilitation's Intervention at Home (NCT01689948)

Eligibility criteria:
Patient's inclusion criteria:

          -  Aged 65 and over

          -  AD or mixed dementia (DSM IV TR criteria), documented by a neuropsychological
             assessment and a brain imaging

          -  Living at home

          -  Having a caregiver (more than 2 visits per week)

          -  Agreement for the study

        Caregiver's inclusion criteria :

          -  More than 2 patient's visits per week

          -  Agreement for the study

        Patient's exclusion criteria:

          -  Life expectancy less than 1 year

          -  Guardianship

          -  Already having a rehabilitation program's therapy

          -  Participation in a pharmacological study

        Caregiver's exclusion criteria:

        - Medical condition requiring regular care
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 65 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Levonorgestrel-releasing Intrauterine System for the Treatment of Symptomatic Adenomyosis (NCT03027648)

Eligibility criteria:
Inclusion Criteria:

          -  Women with regular menses

          -  Adenomyosis diagnosed via transvaginal ultrasound

          -  With severe dysmenorrhea (VAS ≥ 7) and/or menorrhea (pictorial chart scores >100)

          -  Duration of placement > 12 months

          -  Size of uterus by physical examination less than uterus of 12-week pregnancy

        Exclusion Criteria:

          -  Desire for pregnancy or lactation

          -  With diagnosis of malignancies or precancerous lesions

          -  Acceptance of laparotomy

          -  Contraindication of placing levonorgestrel-releasing intrauterine system
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Role of Cryobiopsy in Diagnosis of Pleural Effusion (NCT03828903)

Eligibility criteria:
Inclusion Criteria:

        - 1. Unilateral moderate or massive exudative pleural effusion patients. 2. Undiagnosed
        pleural effusion after simple pleural fluid aspiration, cytology or blind (closed) pleural
        biopsy using Abram's needle.

        3. Age>18 years old

        Exclusion Criteria:

          1. Transudative pleural effusion.

          2. Exudative pleural effusion less than one third of hemithorax.

          3. Presence of hemorrhagic diathesis (prothrombin concentration <50% and platelet count
             <80,000/mm 3).

          4. Poor performance state (ECOG performance status >4) as recommended in BTS (British
             thoracic society) guidelines 2010.

          5. Sever uncontrollable cough, hypercapnia and sever respiratory distress.

          6. Fibrothorax, excessive pleural adhesion.

             -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? Contradiction
Clinical trial: Clinical and Radiographic Evaluation in Pulpotomy of Primary Molars Using Protooth Vs. MTA (NCT04710160)

Eligibility criteria:
Inclusion Criteria:

          -  Complete physical and mental health, with no confounding history of systemic disease
             and/or use of special local or systemic drugs

          -  No allergic reactions recorded in patient history

          -  Having primary molar teeth in one jaw, having deep caries and vital pulp.

          -  No history of spontaneous pain, pathologic mobility, draining sinus tract, redness or
             swelling of vestibule

          -  Normal gingival and periodontal condition, with no sensitivity to vestibular
             palpation, and no pain on percussion test

               -  Radiographic criteria:

          -  No sign of radiolucency in periapical or furcation area

          -  No widening of PDL space or loss of lamina dura continuity

          -  No evidence of internal/external pathologic root resorption

        Exclusion Criteria:

          -  Lack of informed consent by the child patient's parent

          -  Lack of informed consent by the child patient's parent

          -  Unable to attend follow-up visits.

          -  Refusal of participation.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 4 Years old.
Subject must be at most 8 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction