araag2/NLI4PR huggingface dataset:
Clinical trial: Steroid-reducing Effects of Crisaborole (NCT03832010)

Eligibility criteria:
Inclusion criteria:

          -  Children aged 2 or older (<18).

          -  Diagnosed with atopic dermatitis.

          -  At baseline, AD is mild to moderate (score of 2 [mild] to 3 [moderate]) on the
             Investigator's Global Assessment scale (IGA; scores range 0-4, higher indicates
             greater severity).

        Exclusion criteria:

          -  Known allergy to a constituent of the studied products (crisaborole, vehicle,
             Aquaphor, topical steroids [hydrocortisone 2.5% ointment and triamcinolone acetonide
             0.1% ointment]).

          -  At baseline, AD is severe (score of 4 [severe] on the IGA scale).

          -  Medical problems which interfere with completion of protocols in this study.

          -  Pregnant or lactating females. (Females who have experienced menarche will be required
             to take a urine pregnancy test.)

          -  Participant is enrolled in another research study.

          -  Participant or participant's guardian(s) are unable to follow instructions as required
             in this study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 2 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 2-year-old boy is brought to the office by his parents due to a rash that started 1 week ago.  A similar red, itchy rash on the cheeks, trunk, and arms has occurred intermittently since infancy.  The patient has had a few upper respiratory infections but no major illnesses.  Vaccinations are up to date, and he takes no medications. He is on a balanced diet, and he is healthy in appearance.  Vital signs and milestone examination are within normal limits.  Similar findings are observed on the cheeks and proximal upper extremities.  The diaper area is clear, and no mucosal lesions are present.

Patient description (patient's own words): I just brought my two-year-old son to the doctor's office because he had a rash for like one week. His rash was on the cheeks, the trunk, and his arms. He already had this before, and it keeps coming back from time to time to time. In the past, he had some respiratory infections but he has never been this sick. His vaccinations are up to date, and he doesn't take any medication. He's healthy with a nice diet. The doctor told me his vitals and milestone examinations were normal. The doctor also said there was a rash around the cheek and the upper part of his arms. The diaper area is okay, and there are no lesions.

Does the patient match the trial criteria? 1
Clinical trial: Correlation of the Inflammatory Parameters With Pain and Radiological Findings in Coxarthrosis (NCT04796129)

Eligibility criteria:
Inclusion Criteria:

          -  Being diagnosed with hip osteoarthritis

          -  Being aged at 45 years or older

        Exclusion Criteria:

          -  Not accept being participation in the study.

          -  Having any systemic disease like the diabetes mellitus, hypertension, coronary after
             disease

          -  Having any inflammatory rheumatologic disease

          -  Having any disease that prevent to participate the study like mental retardation,
             dementia and psychotic disorders.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 0
Clinical trial: Autoantibodies on Spinal Cord Injury (NCT02493543)

Eligibility criteria:
Inclusion Criteria:

          -  Traumatic or non-progressive vascular SCI

          -  Less than 45 days after lesion

          -  Any neurological level

          -  Complete and incomplete lesions

          -  If patient has been treated with glucocorticoids, it should have passed at least 7
             days from the end of the treatment

        Exclusion Criteria:

          -  Cauda equina syndrome

          -  Autoimmune disorder

          -  Tumor (even if benign)

          -  Neurodegenerative disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient description (patient's own words): I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Does the patient match the trial criteria? 0
Clinical trial: Autologous Intrauterine Platelet-Rich Plasma Instillation And Endometrial Scratching for Thinned Endometrium (NCT04240860)

Eligibility criteria:
Inclusion Criteria:

        Endometrial thickness < 7 mm under estrogen replacement therapy or repeated implantation
        failure Age between 18 and 38years

        Exclusion Criteria:

        Age < 18 and > 46 years Pregnancy Bleeding diathesis Previous uterine surgery (miomectomy,
        cesarean section, etc...) Platelet count < 105/μL Hemoglobin < 10 g/dL Presence of a tumor
        in the wound bed or metastatic disease Current diagnosis of cancer Other concomitant active
        infections Other factors of infertility ( PCO, tubal block, congenital anomalies, genetic
        malformation, male infertility)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 38 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 1
Clinical trial: Safety and Efficacy of Somatropin in Children With Growth Hormone Deficiency (NCT01502124)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of short stature (height maximum 2 standard deviations of mean for age and
             gender) or inadequate growth deemed secondary to growth hormone deficiency (GHD)

          -  Naïve to growth hormone therapy

        Exclusion Criteria:

          -  Known or suspected allergy to the trial product or related products

          -  Growth retardation attributable to causes other than GHD. Growth retardation
             attributable to diabetes mellitus, inborn errors of metabolism, primary bone disease,
             chromosomal disorders or disease of the genitourinary, cardiopulmonary,
             gastrointestinal or central nervous system; bone marrow transplantation or any
             syndrome known to give short stature (examples are: Prader-Willi Syndrome,
             Russell-Silver Syndrome, Turner Syndrome, Noonan Syndrome)

          -  Intrauterine growth retardation: birth weight below 3rd percentile, adjusted for
             gestational age

          -  Pregnancy or the intention to become pregnant

          -  Breast-feeding

          -  Administration of other growth-altering medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 0
Clinical trial: Comparison of Medical Therapies in Marfan Syndrome. (NCT01295047)

Eligibility criteria:
Inclusion Criteria:

          -  Ages 16-60 years old with no treatment or β-blocker or other monotherapy only for
             Marfan syndrome

        Exclusion Criteria:

          -  Previous aortic dissection or aortic surgery

          -  Severe valvular regurgitation

          -  Aortic diameter at the sinotubular junction ≥ 5.0cm

          -  Contraindications to specific drug treatment, e.g. asthma and β-blocker

          -  Those who were pregnant or at risk of pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? 1
Clinical trial: Accuracy of Commercially Available Heart Rate Monitors (NCT02697214)

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  Able and willing to exercise (walk/jog) for a total of fifteen minutes

        Exclusion Criteria:

          -  Health issues that preclude or contraindicate walking and/or jogging, including
             cardiovascular, orthopedic, pulmonary and other conditions

          -  Presence of a cardiac pacemaker

          -  Known cardiovascular disease

          -  Known heart rhythm disorders

          -  Use of Beta-blockers or antiarrhythmic medications

          -  Tattoos around the wrist area
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? 1
Clinical trial: An Innovative Mind-motor Exercise Approach to Osteoarthritis Treatment (NCT02753634)

Eligibility criteria:
Inclusion Criteria:

          -  Knee osteoarthritis

        Exclusion Criteria:

          -  WOMAC less than 4

          -  Use of braces

          -  Uncontrolled hypertension

          -  Significant psychiatric or psychotic disorder

          -  Not able to attend 75% of sessions

          -  Any other reason that would prevent participation
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 1
Clinical trial: Pharmacokinetics Evaluation of Recombinant Coagulation Factor VIII Injection in Subjects With Hemophilia A. (NCT04060836)

Eligibility criteria:
Inclusion Criteria:

          1. Hemophilia A.

          2. FVIII:C <1%. 3）12 and 65 years old.

        4）Has received FVIII treatment and the treatment exposure days ≥100. 5）Has bleeding
        treatment records of at least 3 months before randomization. 6）FVIII inhibitor assay
        results is negative.

        7） Subjects should agree to use an adequate method of contraception during the study.

        8）Understood and Signed an informed consent form. 9）Has not received an treatment of any
        FVIII within 4 days before the first dose.

        10）Non-bleeding state.

        Exclusion Criteria:

          1. Has a history or family history of blood coagulation factor VIII inhibitor.

          2. Has other coagulation dysfunction diseases in addition to hemophilia A.

          3. HIV positive.

          4. Plan to receive surgery during the trial.

          5. Has used immunomodulator within one weeks before the first dose，and less than 7
             half-life periods.

          6. Known to be allergic to experimental drugs or any excipients.

          7. Severe anemia and need blood transfusion.

          8. Serious liver or kidney damage.

          9. Serious heart disease.

         10. Uncontrollable hypertension.

         11. Has participated in other clinical studies within one month before the first dose.

         12. The researchers believe that it is not suitable for participants.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Re-exposure Study of Pegloticase Intravenous (i.v.) in Symptomatic Gout Patients (NCT00675103)

Eligibility criteria:
Inclusion Criteria:

          -  Previous treatment in studies of pegloticase i.v.

          -  Last exposure to pegloticase i.v. greater than one year prior to study entry

          -  Symptomatic gout

          -  Documented hyperuricemic (SUA ≥ 7 mg/dL)

        Exclusion Criteria:

          -  Prior exposure to Elitek® (rasburicase)

          -  Unstable angina

          -  Uncontrolled arrhythmia or hypertension

          -  Non-compensated congestive heart failure

          -  End stage renal disease requiring dialysis

          -  Concomitant use of SUA lowering agents and use of other investigational drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 0