araag2/NLI4PR huggingface dataset:
Clinical trial: The Effects of Fluidotherapy® Exercise (NCT03649542)

Eligibility criteria:
Inclusion Criteria:

          -  Participants must be referred to outpatient rehabilitation at St. Thomas Hospital,
             Akron, Ohio.

          -  Patients diagnosed with a wrist fracture will include those patients with distal
             radius fractures, distal radius/ulna fractures, and distal ulna fractures. Patients
             who have had closed reductions, open reductions, internal fixation, and/or external
             fixation will all be included.

          -  Patients will be recruited for this study if they have been cleared by the referring
             physician on the order to safely begin wristrange of motion.

        Exclusion Criteria:

          -  Have open wounds

          -  Have Hepatitis

          -  Currently have chicken pox or shingles

          -  Have other serious fractures in the arm

          -  Have blood circulation problems in the arms or legs

          -  Do not have a physician referral to outpatient rehab

          -  Fractured wrist less than 6-weeks old as of evaluation day

          -  Fractured wrist over a year ago

          -  Under the age of 18 and over the age of 85 years at the time of participation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? 0
Clinical trial: Assessment of Long Term Treatment With Testosterone Undecanoate in Males With Hypogonadism (NCT00220298)

Eligibility criteria:
Inclusion Criteria:

          -  Hypogonadal men, aged 18-75 years with low serum total testosterone (TT) levels and
             symptoms of androgen deficiency

        Exclusion Criteria:

          -  Tumors of the prostate or the male mammary gland including suspicion thereof. Past or
             present liver tumors or chronic hepatic disease with impairment of liver function,
             Severe acne.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? 1
Clinical trial: Study of DS-5141b in Patients With Duchenne Muscular Dystrophy (NCT02667483)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmation of out-of-frame deletion(s) that could be corrected by dystrophin gene
             exon 45 skipping.

          -  Intact muscles of adequate quality for biopsy to allow evaluation of the efficacy of
             the study drug.

          -  Boys aged from 5 years to <11 years.

          -  Patients able to walk at least 325 meters in the 6-minutes walk test.

          -  Glucocorticoid-naive patients, or patients who have used glucocorticoids for at least
             6 months prior to enrollment in this study with no dose changes for at least 3 months
             prior to enrollment.

        Exclusion Criteria:

          -  A genetic mutation that can not be expected the expression of dystrophin protein by
             dystrophin gene exon 45 skipping.

          -  A concurrent illness other than DMD that can cause muscle weakness and/or impairment
             of motor function.

          -  Current or history of severe disorder.

          -  Left ventricular ejection fraction (LEVF) <55%.

          -  Corrected QT interval (QTc) >0.45 sec.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 10 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 1
Clinical trial: Second Molecular Event Identification by Exome Sequencing for Intellectually Disabled Patients Carrying 16p13.11 CNVs (NCT03644797)

Eligibility criteria:
Inclusion Criteria:

          -  Patients presenting intellectual disability

          -  Patients carrying a 16p13.11 copy number variant

          -  Blood DNA available without re sampling for the patient and his parents.

          -  Consent for genetics analysis already for the patient and his parents.

        Exclusion Criteria:

        - Other diagnosis for intellectual disability (apart 16p13.11 copy number variant) already
        posed
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? 0
Clinical trial: The Effect of Non Invasive Electrical Stimulation Therapy on Gastroesophageal Reflux Disease (GERD) Symptoms - Proof of Concept Study (NCT02500264)

Eligibility criteria:
Inclusion Criteria:

          -  at least 3 episodes of heartburn and/or regurgitation in a week for at least 3 months.

          -  evidence for an abnormal esophagal acid exposure on impedance-pH monitoring (tested in
             the last 2 years off PPI)

        Exclusion Criteria:

          -  gastric or esophagal surgery

          -  active peptic ulcer disease

          -  malignancy

          -  pregnancy

          -  uncontrolled diabetes mellitus

          -  severe cardiac conditions such as cardiac arrhythmia or ischemia or cardiac
             pacemaker/defibrillator

          -  allergy to adhesives/patches

          -  severe pulmonary disease

          -  obesity (BMI>30)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 0
Clinical trial: Survivin as Predictive Biomarker for RA (NCT03444623)

Eligibility criteria:
Inclusion Criteria:

          -  Patients seeking treatment at the primary health care for problems with their joints
             (pain, stiffness).

        Exclusion Criteria:

          -  Patients diagnosed with RA
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1
Clinical trial: Effect of Lithium Carbonate in Patients With Amyotrophic Lateral Sclerosis (NCT00925847)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of clinically possible, clinically probable laboratory-supported, clinically
             probable or clinically definite ALS (according to WNF EL Escorial diagnostic criteria,
             revised according to the AIRLIE House Conference 1998)

          -  Concomitant standard Riluzole therapy (50mg twice daily)

          -  patients included in ALS reference center

          -  women of childbearing age be non-lactating and surgically sterile or using a highly
             effective method of birth control and have a negative pregnancy test

          -  capable of thoroughly understanding all information given and giving full informed
             consent according to GCP

          -  Patients with gastrostomy

        Exclusion Criteria:

          -  evidence of major psychiatric disorder or clinically evident dementia precluding
             evaluation of symptoms

          -  any medical condition known to contre-indicate lithium treatment (dysthyroid,
             cardiopathy, renal insufficiency)

          -  presence of any concomitant life-threatening disease or impairment likely to interfere
             with functional assessment

          -  known hypersensitivity to any component of the study drugs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? 1
Clinical trial: Human Epidermal Growth Factor Receptor 2 (HER-2) Status in Gastric and Gastro-Esophageal Junction (GEJ) Carcinoma (NCT02731313)

Eligibility criteria:
Inclusion Criteria:

          -  Tumor samples with histologically confirmed gastric or gastro-esophageal junction
             (GEJ) adenocarcinoma, any stage

          -  Samples with sufficient tumor material for centralized analysis

          -  Samples fixed and embedded in paraffin (formalin-fixed paraffin-embedded tissue
             [FFPET] samples).

        Exclusion Criteria:

        - Fixatives not allowed: Bouin's solution
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? 1
Clinical trial: Effects of Action Observation Therapy on Pain, Functional Level and Brain Hemodynamic in Patients With Knee Osteoarthritis (NCT03245073)

Eligibility criteria:
Inclusion Criteria:

          -  Between 45 to 70 years;

          -  Unilateral knee osteoarthritis according to clinical and radiological criteria

          -  Grade 2 or Grade 3 according to Kellgren-Lawrance Scale

          -  Right-handed according to Edinburgh Handedness Scale

          -  Chronic pain during the rest or activity above 4 points according to the Verbal Rating
             Scale

        Exclusion Criteria:

          -  Having neurological or psychiatric diseases

          -  Having chronic pain due to another pain disorder

          -  Having rheumatic diseases

          -  Using antidepressant medications or opioids

          -  Knee surgery within one year prior to the study

          -  Intraarticular injection and attend physical therapy within 6 months prior to the
             study

          -  Mini Mental State Examination Scale score below 24
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 0