araag2/NLI4PR huggingface dataset:
Clinical trial: Very Small Embryonic-like Stem Cells for Knee Osteoarthritis (NCT03975101)

Eligibility criteria:
Inclusion Criteria:

          -  Patients had moderate to severe osteoarthritis of both knees.

          -  Those had mechanical pain of knee joints, which was aggravated by walking or stair
             climbing.

          -  Those complained of gelling pain of knee joint.

          -  Those have crepitus and limitation of the joint range of motion with joint bony
             hypertrophy on physical examination, X-rays showed narrowing of joint space and
             osteophyte formation

        Exclusion Criteria:

          -  Diabetic foot and patients with obvious edema in the legs caused by various causes

          -  Blood disease patients, thrombocytopenia or dysfunction, hypofibrinemia or
             anticoagulant therapy, long-term use of aspirin
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 1
Clinical trial: 3D vs 2D HD Laparoscopy in Inguinal Hernia Repair (NCT02367573)

Eligibility criteria:
Inclusion Criteria:

          -  Patients scheduled for laparoscopic inguinal hernia repair

        Exclusion Criteria:

          -  Some other surgical operation planned during TAPP

          -  Expected major risk of conversion (e.g. multiple previous abdominal operation,
             previous peritonitis)

          -  Operating surgeon experience less than 5 3D laparoscopy operations
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: Dose Response Relationship for Single Doses of Corticotropin Releasing Hormone (CRH) in Normal Volunteers and in Patients With Adrenal Insufficiency (NCT00001180)

Eligibility criteria:
INCLUSION CRITERIA:

        The normal volunteers are obtained through the NIH volunteer program or are NIH employees.
        Normal volunteers are in excellent health and are receiving no chronic medications.

        We now routinely test patients with hypocortisolism or hypercortisolism in our clinic and
        ward.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? 1
Clinical trial: Neuro-muscular Exercise Training Verses Quadriceps Training in Mild to Moderate Knee Osteoarthritis (NCT03798002)

Eligibility criteria:
Inclusion Criteria:

          -  UL/BL knee OA,

          -  Age 40-65, both genders,

          -  American college of rheumatology criteria for knee OA,

          -  Grade 2 or 3 on Kellgren/Lawrence classification for Knee OA.

        Exclusion Criteria:

          -  Knee surgery

          -  Rheumatoid arthritis

          -  Any neurological condition affecting lower limbs and balance

          -  Use of assistive devices for walking.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Acute Effects of Vinyasa Yoga on Vascular Function (NCT04226235)

Eligibility criteria:
Inclusion Criteria:

          -  Having normal (systolic blood pressure <120 mm Hg with a diastolic <80 mm Hg) or
             elevated blood pressure (systolic blood pressure 120-129 mm Hg) or stage 1
             hypertension (systolic blood pressure 130-139 mm Hg or a diastolic blood pressure
             80-89 mm Hg).

          -  Must have had at least 3 months of prior yoga experience.

        Exclusion Criteria:

          -  A history of cardiovascular disease or cardiac events, pregnancy, infection within the
             last 4 weeks, chronic obstructive pulmonary disease (COPD), endocrine or renal
             disease, metabolic disorders, or debilitating muscular, joint and bone injury.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? 1
Clinical trial: Turner Syndrome: Genotype and Phenotype (NCT00006334)

Eligibility criteria:
-  INCLUSION CRITERIA - for TS Subjects:

        Phenotypic females greater than or equal to 10 years of age

        Evidence of X-chromosomal abnormality

        Those with a karyotype of 45X/46XX must have at least 80% 45X lymphocytes.

        EXCLUSION CRITERIA - for TS Subjects:

        Co-existing autosomal defects

        Pregnancy

        INCLUSION CRITERIA - for the Parents of TS Subjects (for DNA only):

        Biological parent of a TS subject

        Willingness to participate

        EXCLUSION CRITERIA - for the Parents of TS Subjects (for DNA only):

        None
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 10 Years old.


Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 0
Clinical trial: Genes-in-Action - Hepcidin Regulation of Iron Supplementation (NCT03341338)

Eligibility criteria:
Inclusion Criteria:

          -  Be healthy and over 18 years of age old.

          -  Have provided appropriate ethical consent for involvement in studies relating to
             genetics.

          -  Have available genotype data based on previous or ongoing genetic studies. Fasted
             (overnight)

        Exclusion Criteria:

          -  Indication of infection/inflammation at the time of enrollment as determined by
             self-reporting, medical history or hematology (full blood count)

          -  Severe anemia (HGB<7 g/dL)

          -  Pregnant and lactating women

          -  Carrier of known genetic variants associated with iron metabolism (sickle trait, G6PD
             deficiency variants, HFE polymorphisms
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? 0
Clinical trial: Sodium Hyaluronate Ophthalmic Solution, 0.18% for Treatment of Dry Eye Syndrome (NCT01382225)

Eligibility criteria:
Inclusion Criteria:

          -  Documented history of dry eyes for at least 3 months.

          -  Ocular discomfort due to dry eyes.

          -  Presence of corneal and conjunctival staining.

          -  Other protocol-defined inclusion criteria may apply.

        Exclusion Criteria:

          -  Women who are pregnant or lactating.

          -  Contact lens wear within 1 week before Screening and during the study.

          -  Ocular surgery (of any type, including laser surgery) or ocular trauma within the 4
             months prior to Screening.

          -  Punctal plugs or punctal occlusion initiated within 3 months of screening

          -  Other protocol-defined exclusion criteria may apply.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 0
Clinical trial: Effects of Cranberry Extractive on the Lipid Profiles in Subjects With Type 2 Diabetes (NCT00695526)

Eligibility criteria:
Inclusion Criteria:

          -  type 2 diabetic subjects

          -  age between 50 and 75 years

        Exclusion Criteria:

          -  glycosylated hemoglobin (HbA1c) less than 7% or more than 10%;

          -  triglyceride more than 4.5 mmol/L;

          -  current insulin treatment;

          -  change of the medications for anti-diabetes, hypertension, hyperlipidemia and
             anti-platelet in recent four weeks;

          -  abnormal renal function (serum creatinine > 177 μmol/L;

          -  abnormal liver function test results (more than two-fold upper limit of normal range);

          -  severe systemic disease such as immune disorder, cancer, acute or chronic inflammation
             disease;

          -  smoking in recent 1 year;

          -  alcoholism (more than two drinks daily);

          -  using steroid or drugs with unknown components;

          -  pregnancy or breast-feeding.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? 1
Clinical trial: The Role of Physical Activity for Acute Exacerbations of COPD (NCT03855670)

Eligibility criteria:
Inclusion Criteria:

          -  COPD GOLD stage B or higher

          -  Written informed consent

        Exclusion Criteria:

          -  Inability to provide written informed consent

          -  Insufficient knowledge of the trial language
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? 0