araag2/NLI4PR huggingface dataset:
Clinical trial: Zingiber and Acmella Against Knee Osteoarthritis (NCT03907787)

Eligibility criteria:
Inclusion Criteria:

          -  established moderate knee OA (classification 1-3 according to Kellgren and Lawrence
             system for classification of knee OA)

          -  Lequesne Index of 6-10; 3) Body Mass Index (BMI) between 22 and 30 kg/m2

          -  aged 40-75

          -  no drugs for OA, such as nonsteroidal anti-inflammatory drugs (NSAIDs).

        Exclusion Criteria:

          -  diabetes, metabolic disease, or neoplasia, as well as the patients with disabling
             diseases that could directly affect muscle weakness (such as neurological diseases,
             hip fractures, or amputations)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: D-chiro-inositol, a Putative Aromatase Inhibitor, Increases Androgen and Reduces Estrogen Levels in Serum of Male Volunteers. A Pilot Study. (NCT04615767)

Eligibility criteria:
Inclusion Criteria:

          -  Body mass index (BMI) range is between 22 and 34 kg/m2, in order to include subjects
             with normal weight, overweight and obese. Subjects with altered glycemia or hormonal
             status due to age or weight were enrolled in the study.

        Exclusion Criteria:

          -  Men with poor general health were excluded from the study.
Male
Accepts Healthy Volunteers
Subject must be at least 30 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? 0
Clinical trial: Risk Stratification of Patients With Suspected COVID-19 Presenting to the ED (NCT04682093)

Eligibility criteria:
Inclusion Criteria:

          -  Adult patients (>= 18 years old) attending the ED with a clinical suspicion of
             COVID-19 based on the presence of the following criteria

          -  Fever >= 38 °C

          -  respiratory symptoms (dyspnea, cough, expectorations)

          -  any other symptoms suggestive of COVID-19 including digestive signs (diarrhea,
             anosmia…)

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 130 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: Ataxia in Essential Tremor: Describing the Differences Between Disease Process and Treatment Effect (NCT03769961)

Eligibility criteria:
Inclusion Criteria:

          -  Essential Tremor diagnosis at least 3 years duration

          -  Absence of other neurological signes (such as dystonia, ataxia, or Parkinsonism)

          -  Patients must be able to walk 2 minutes unassisted.

          -  Patients must be able to understand and consent to be in the study.

        Exclusion Criteria:

          -  Patients who have had changes in DBS settings within the last 3 months.

          -  Patients who have had no initial improvement or response to DBS.

          -  ET medication changes in the last month.

          -  Actively abusing alcohol.

          -  A neurologic diagnosis other than ET that in the investigator's opinion could affect
             gait and/or balance.

          -  Atypical tremor disorder including by not limited to tremor due to multiple sclerosis,
             medication-induced tremor, Parkinson's disease, or parkinsonian syndrome.

          -  Dementia
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 1
Clinical trial: A Study of Flt3-Ligand Levels in Sjögrens Syndrome (NCT01470638)

Eligibility criteria:
Inclusion Criteria:

          -  fulfill the ACR-criteria for primary Sjogrens syndrome,

          -  age above 18 years old

        Exclusion Criteria:

          -  other CNS-disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1
Clinical trial: Vaccination for Middle Ear Infection (NCT00001605)

Eligibility criteria:
Healthy volunteers between ages 18 and 35 years.

        Not pregnant or planning to become pregnant in next six months.

        HIV negative.

        Hepatitis B Negative.

        No chronic Respiratory Tract Infections.

        No history of abnormal immune system.

        No severe or multiple allergies.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? 1
Clinical trial: Study of Merimepodib in Combination With Remdesivir in Adult Patients With Advanced COVID-19 (NCT04410354)

Eligibility criteria:
Inclusion Criteria:

          -  At least 18 years old

          -  Confirmed SARS-CoV-2 viral infection

          -  Advanced COVID-19 with score of 3 or 4 on NIAID scale (first 40 patients) or score of
             3 on NIAID scale (last 40 patient

          -  Has at least one of the following: fever, cough, sore throat, malaise, headache,
             muscle pain, shortness of breath, confusion or severe lower respiratory symptoms

          -  Off antiviral medications at least 24 hours prior to first dose of study drug (except
             for remdesivir)

          -  Able to provide consent

          -  Agree to appropriate methods of contraception

        Exclusion Criteria:

          -  In critical condition or has ARDS

          -  On invasive mechanical ventilation or ECMO

          -  Bacterial or fungal infection

          -  Pregnant or lactating (women)

          -  ALT >5x ULN, bilirubin >2x ULN, INR outside of normal limits at screening

          -  eGFR <30 mL/min

          -  Clinically relevant serious co-morbid medical conditions

          -  Treatment with any immunosuppressive therapy within 30 days prior to screening

          -  Treatment with another investigational drug within 30 days or 5 half-lives of drug
             prior to screening

          -  Prior treatment with the study drug (MMPD) or treatment with remdesivir more than 24
             hours prior to the first randomized dose of study drug

          -  Known hypersensitivity to the inactive ingredients in the study drug (MMPD or placebo)
             or any ingredient of remdesivir
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitors (NCT04684940)

Eligibility criteria:
Inclusion Criteria:

          1. Males ≥ 18 years of age with hemophilia A and documented prior residual FVIII activity
             ≤ 1 IU/dL including, but not limited to, at the time of detected inhibitors, at the
             time of signing the informed consent.

          2. History of a positive inhibitor result with the first positive result in the last 12
             months.

             Part A: Positive FVIII inhibitor titer ≥ 0.6 BU. Part B: Negative FVIII inhibitor
             screening titer < 0.6 BU.

          3. Part A: Emicizumab prophylaxis at least 6 months prior to screening; Part B: FVIII
             replacement prophylaxis for 12 months. Bleeding, inhibitor & hemophilia therapy Hx
             over previous 12 months.

          4. Sexually active participants must agree to use an acceptable method of effective
             contraception. Participants must agree to contraception use for at least 12 weeks
             post-infusion.

          5. Willing to abstain from consumption of alcohol for at least the first 52 weeks
             following BMN 270 infusion.

        Exclusion Criteria:

          1. Detectable pre-existing antibodies to the AAV5 capsid.

          2. Any evidence of active infection or any immunosuppressive disorder, including HIV
             infection.

          3. Currently undergoing, or plan to receive during the study, immune tolerance induction
             therapy or prophylaxis with FVIII (Part A only).

          4. Significant renal dysfunction or liver dysfunction, infection or history of hepatic
             malignancy.

          5. Evidence of any bleeding disorder not related to hemophilia A.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: The IGFBP-3 Stimulation Test: A New Tool for the Diagnosis of Growth Hormone Deficiency in Children. (NCT00235599)

Eligibility criteria:
Inclusion Criteria:

          -  Bone age < 10 years female, < 12 years male

          -  Pubertal status: Girls: Tanner I for breast development. Boys: testicular volume of ≤
             3 cc, as measured by the standardized orchidometer (Prader type). The onset of pubic
             hair development up to and including Tanner III is allowed in the study.

          -  Adequate nutrition: body mass index ≥ 25th percentile for gender.

        Exclusion Criteria:

          -  Syndromic short stature

          -  Chronic illnesses.

          -  Other disorders, including osteo- or chondrodystrophies, and endocrine causes of short
             stature such as Cushing syndrome, and untreated hypothyroidism.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 4 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 0
Clinical trial: Cognition, Steroids, and Imaging in Cushings Disease (NCT00081341)

Eligibility criteria:
Inclusion criteria:

          -  patients with suspected Cushing's syndrome with clinical findings suggestive of
             Cushing's syndrome and positive screening tests (urinary free cortisol and low dose
             overnight dexamethasone suppression test).

        Exclusion criteria: none
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 9 Years old.


Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? 1
Clinical trial: Duchenne Muscular Dystrophy Heart Study (NCT03443115)

Eligibility criteria:
Inclusion Criteria:

          -  Genetically-proven Duchenne Muscular Dystrophy (DMD mutation)

          -  Covering by social security

        Exclusion Criteria:

          -  Patient refusal to participate to the study
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 1