araag2/NLI4PR huggingface dataset:
Clinical trial: A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease (NCT04520412)

Eligibility criteria:
Inclusion Criteria:

          -  Mild to moderate AD per NIA-AA.

          -  History of cognitive and functional decline over at least 1 year.

          -  MMSE scores between 11 and 24 (inclusive) at baseline.

          -  Brain MRI scan show the highest possibility of AD.

          -  Have a study partner/caregiver.

        Exclusion Criteria:

          -  Diagnosis of a dementia-related central nervous system disease other than AD.

          -  Major structural brain disease as judged by MRI.

          -  A resting heart rate of < 50 beats per minute (bpm) after 5 minutes of rest in sitting
             or supine position.

          -  Major medical illness or unstable medical condition within 6 months of screening.

          -  Concomitant use of AChEIs and/or memantine within 30 days before first MMSE score, and
             during the study.

          -  Inadequate hepatic function.

          -  Inadequate organ and marrow function.

          -  ECG clinically significant abnormalities.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 1
Clinical trial: Efficacy and Mechanisms of Energy Medicine to Decrease Chronic Knee Pain in Outpatient Settings (NCT03637595)

Eligibility criteria:
Inclusion Criteria:

          -  Presence of knee pain lasting for at least six months

          -  No radiation of knee pain

          -  No acupuncture treatments in the previous six months

          -  Failure to respond completely to the medications given by their orthopedic or pain
             management specialist

          -  Knee pain on most days (4 out of 7 days of the week) with average self-reported
             severity of 4 or more out of 10 on a numeric rating scale (NRS)

          -  Complaints of morning stiffness lasting less than 30 minutes

          -  Not be in active physical therapy (PT) for the duration of the trial.

          -  Adult patients ≥18 years of age

          -  English speaking

        Exclusion Criteria:

          -  Any concurrent diagnosis of systemic disease

          -  Other concurrent treatments such as massage, Acupcunture, PT or any kind of Energy
             Medicine

          -  Bleeding disorder

          -  Trypanophobia (fear of needles or injections).

          -  Have medical condition that causes difficulty in saliva production/collection (i.e.:
             Sjogren's Syndrome)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Effects of Mineral Water Consumption on Serum Lipid Parameters (NCT00812617)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy as based on medical history and physical examination

          -  Fasting serum LDL cholesterol > 100 and/or fasting serum triglyceride > 100

          -  Willing to drink mineral water for 12 weeks

          -  Willing not to serve as blood donor during the study

          -  Informed consent signed

        Exclusion Criteria:

          -  Female subjects who are pregnant or nursing a child

          -  Participation in any clinical trial up to 90 days before Day 01 of this study

          -  Renal or hepatic dysfunction

          -  Heart disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1
Clinical trial: Study Evaluating rFIX; BeneFIX in Severe Hemophilia B (NCT00037557)

Eligibility criteria:
Inclusion Criteria:

          -  Severe hemophilia B

          -  Less than 5 years of age

          -  In the investigator's judgment, the patient and/or caregiver will be compliant to
             study procedures

        Exclusion Criteria:

          -  A currently detectable FIX inhibitor. A family history of inhibitors will not exclude
             the patient.

          -  Impaired liver function

          -  Impaired renal function
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 5 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: World Bleeding Disorders Registry Pilot Study (NCT02776826)

Eligibility criteria:
Inclusion Criteria:

          -  Patients of participating Hemophilia Treatment Centres with Hemophilia A or B.

          -  Ability to provide data in English

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1
Clinical trial: The Intervention of Multi-vitamin With Minerals to Hyperuricemia (NCT03218709)

Eligibility criteria:
Inclusion Criteria:

          -  Under the dietary pattern of normal intake of purine, the level of serum uric acid is
             higher than 420μmol/L for male or 360μmol/L for female (not be detected twice at the
             same day).

        Exclusion Criteria:

          -  Gouty arthritis, tophus or gouty nephropathy.

          -  Complications including diabetes, cardiovascular diseases (angina, myocardial
             infarction) and so on.

          -  Taken hypouricemic medicine in the last week before intervention, including
             allopurinol, benzbromarone, probenecid and so on.

          -  Had an operation in the past year.

          -  Malnutrition or severe obesity, BMI<18.5kg/m2 or >30.0 kg/m2.

          -  Mental diseases, tumor, hepatic cirrhosis or other diseases that may interfere with
             the intervention.

          -  Alcohol abuse (>80g/d)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 22 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 0
Clinical trial: Clinical and Genetic Study of Familial Sarcoidosis (SARCFAM) (NCT02829853)

Eligibility criteria:
Inclusion Criteria:

          -  patient affected by sarcoidosis, as defined by clinical criteria such as : chest X-ray
             staging, pulmonary function tests, biological variables: serum calcium and creatinine,
             bronchial alveolar lavage cell count and when available, an histological confirmation
             of the granuloma by biopsy. The disease may be expressed initially as uveitis,
             cutaneous or other anatomical sites involvement, which must be also confirmed as
             sarcoidosis-related granuloma by competent pathologists.

        Exclusion Criteria:

          -  Any other disease suggesting sarcoidosis and expressed by similar symptoms, as for ex.
             hilar lymphadenopathy, other forms of uveitis, restrictive pulmonary syndromes .. etc
             ….

          -  Any patients for which the follow-up was not available over the 8 year program of the
             GSF SARCFAM

          -  age < 8 years old or > 80 years old
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? 1
Clinical trial: Coronavirus (COVID-19) Outcomes Registries in Immunocompromised Individuals Australia (CORIA) (NCT04354818)

Eligibility criteria:
Inclusion Criteria:

          1. Presenting (in person or via telemedicine) for evaluation because they:

               -  Have clinical symptoms consistent with for COVID-19:

               -  Fever (≥ 37.8 °C) on examination OR patient reported fever (≥ 37.8 °C) or
                  feverishness (felt febrile but did not take temperature) OR any of, cough, sore
                  throat, shortness of breath, rhinorrhoea, headache, chills, generalise myalgia,
                  malaise, fatigue, confusion, diarrhea, nausea or vomiting

               -  Have been contacted because they have been identified as a contact to a confirmed
                  case

               -  Have been contacted and told they tested positive for COVID-19

          2. Have one of the following conditions affecting immune function:

               -  Known or suspected primary immunodeficiency, defined as a predisposition to
                  infection associated with an apparent or presumed deficit of immune function

               -  On immunosuppressive therapy

               -  Treatment with immune checkpoint inhibitors within 36 months of enrolment date

               -  HIV infection

               -  Diagnosis of cancer within 36 months of enrolment date, excluding superficial
                  basal cell and squamous cell carcinomas

               -  Solid organ transplantation

          3. For optional biobanking only, ability to provide informed consent

        Exclusion Criteria:

          -  Nil
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: Pleural Manometry in Thoracocentesis (NCT04420663)

Eligibility criteria:
Inclusion Criteria:

          1. age between 18 and 85 years,

          2. pleural effusion occupying at least one-third of the ipsilateral hemithorax in P-A
             chest radiograph (CXR)

          3. no contraindications for therapeutic thoracentesis

          4. general health condition allowing prolonged procedure of therapeutic thoracentesis.

        Exclusion Criteria:

          -  patients with very small amounts of pleural effusion

          -  patients on mechanical ventilation

          -  patients using anticoagulant therapy

          -  patients refusing to be subjected to thoracocentesis.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? 1
Clinical trial: Efficacy Study of Amazing Me Program (NCT04754126)

Eligibility criteria:
Inclusion Criteria:

          -  Educators teaching 4th and 5th graders. Thus students will be on average between 9 and
             11 years old.

        Exclusion Criteria:

          -  None.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 11 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 1