araag2/NLI4PR huggingface dataset:
Clinical trial: Gracie Diet for Gastroesophageal Reflux Disease (NCT04360252)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years or older at registration.

          -  Patients with ongoing symptoms of GERD: heartburn (pyrosis) mid-sternal chest pain,
             regurgitation of fluid or food, development of esophageal inflammation that may lead
             to swallowing dysfunction, or extraesophageal manifestations (i.e. cough,
             bronchospasms, and hoarseness).

          -  Use of one of the following PPI medications: omeprazole, lansoprazole, pantoprazole,
             rabeprazole, esomeprazole or dexlansoprazole. And/or use of one of the following H2
             blockers medications as well: famotidine, cimetidine, ranitidine or nizatidine.

          -  Willing to comply with the Gracie diet regimen

        Exclusion Criteria:

          -  Age < than 18 years.

          -  Patients unable to speak English.

          -  Pregnancy or nursing.

          -  Complicated oropharyngeal dysphagia or other condition with risk for aspiration from
             oral ingestion.

          -  Exclusion of other causes of symptoms as mechanical gastrointestinal obstruction,
             Barrett's esophagus and cancer of the esophagus by standard radiographic or endoscopic
             test evidenced in the medical record chart.

          -  A prior surgery of the upper gastrointestinal tract.

          -  Failure to give informed consent.

          -  Any other condition, which in the opinion of the investigator would impede compliance
             or hinder the completion of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 1
Clinical trial: The Frequency of Eosinophilic Esophagitis in Patients With Heartburn That is Refractory to Proton Pump Inhibitors (NCT01404832)

Eligibility criteria:
Inclusion Criteria:Male and female patients ages 18 years and older who are referred to the
        Division of Gastroenterology at the Dallas VA Medical Center for the evaluation of
        heartburn that is refractory to PPI therapy

        Exclusion Criteria:

          1. Patients unwilling or unable to provide informed consent.

          2. Allergy to lansoprazole.

          3. Patients taking warfarin.

          4. Coagulopathy that precludes safe biopsy of the esophagus.

          5. Comorbidity that precludes safe participation in the study.

          6. Pregnancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 1
Clinical trial: Study About Patients Using Copper Intrauterine Device (NCT01541241)

Eligibility criteria:
Inclusion Criteria:

          1. Regularly menstruating women before CIUD insertion.

          2. Age between 18 and 35 years.

          3. Hormonal treatment has not been taken at least two months before the study.

          4. Non steroidal anti-inflammatory drugs has not been taken 24 hours before the
             examination.

        Exclusion Criteria:

          1. Pregnancy.

          2. The presence of pelvic pathology as ovarian cysts, pelvic endometriosis, endometrial
             polyps or fibrosis.

          3. Present or past history of pelvic inflammatory disease.

          4. Patients on hormonal treatment in the last two months before the study.

          5. Patients on non steroidal anti-inflammatory drugs last 24 hours before the
             examination.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Bisphosphonates Effects On Alveolar Bone Among Osteoporotic Women (NCT02115490)

Eligibility criteria:
Inclusion Criteria:

          -  Women with osteoporosis who already use bisphosphonates.

          -  Women with osteoporosis who are not under bisphosphonates yet, or are not indicated
             for such therapy.

          -  Women with osteopenia either using or not bisphosphonates.

        Exclusion Criteria:

          -  Women with bone diseases other than osteoporosis or osteopenia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman

Does the patient match the trial criteria? 1
Clinical trial: Comparison of 3 Diagnostic Strategies of PE: Planar V/Q Scan, CTPA, and V/Q SPECT. (NCT02983760)

Eligibility criteria:
Inclusion Criteria:

          -  Outpatients with a clinically suspected PE (defined as an acute onset of new or
             worsening shortness of breath, chest pain, hemoptysis, presyncope, or syncope) without
             another obvious apparent cause.

          -  High pretest clinical probability of PE or a non-high pretest clinical probability but
             a positive D-Dimer test.

        Exclusion Criteria:

          -  Age less than 18 years

          -  Patients with already confirmed PE

          -  Patients with a clinically suspected high-risk pulmonary embolism (hypotension or
             shock)

          -  Use of therapeutic doses of anticoagulants for more than 48 hours

          -  Other indication for long-term use of anticoagulants

          -  Contraindication to contrast media (including renal insufficiency with a creatinine
             clearance lower than 30 ml/min)

          -  Life expectancy less than 3 months

          -  Unable/unwilling to give informed consent

          -  Unlikely to comply with study follow-up

          -  Ongoing pregnancy or breastfeeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? 0
Clinical trial: Study of the Efficacy of Losartan on Aortic Dilatation in Patients With Marfan Syndrome (NCT00763893)

Eligibility criteria:
Inclusion Criteria:

          -  10 years or older

          -  Marfan syndrome according to international criteria Signed informed consent

        Exclusion Criteria:

          -  Previous surgery of the ascending aorta, or surgery planned

          -  Non echogenicity

          -  Contre-indication lactose

          -  Pregnancy on going or planned within 3 years

          -  Breast feeding

          -  Participation in another clinical study

          -  Non member of the social security or CMU
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.


Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? 1
Clinical trial: THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone (NCT03013166)

Eligibility criteria:
Inclusion Criteria:

          1. Cohort 1 (IR hydrocortisone): All patients with a Read code for AI and a prescription
             of IR hydrocortisone between 2010 and data extraction but no prescription for MR
             hydrocortisone at any time during this period, and no earlier prescription for IR
             prednisolone during this period

          2. Cohort 2 (IR prednisolone): All patients with a Read code for AI and a prescription of
             IR prednisolone between 2010 and data extraction but no prescription for MR
             prednisolone at any time during this period, and no earlier prescription for IR
             prednisolone during this period

          3. Cohort 3a (MR Hydrocortisone): All patients with a Read code for AI and a prescription
             of MR hydrocortisone between 2010 and data extraction

          4. Cohort 3b (IR to MR hydrocortisone): A sub-set of patients from cohort 3a, who have
             switched from IR to MR hydrocortisone.

          5. A list of pre-defined READ codes will be used to identify all patients with primary or
             secondary AI or CAH in the THIN database.

        Exclusion Criteria:

        1)Patients who have not received a prescription of hydrocortisone or prednisolone in the
        past five years will be excluded as the aim of the study is to describe recent experience.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? 1
Clinical trial: Frequency of Common Medical Conditions in People With and Without HHT (NCT02464644)

Eligibility criteria:
Inclusion Criteria:

          -  Aged 18 or over.

          -  Capacity to fill in a questionnaire.

        Exclusion Criteria:

          -  Age under 18

          -  Unable to fill in a questionnaire
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? 1
Clinical trial: Human Epididymis Protein 4 in Normal Menstruating Women (NCT01337999)

Eligibility criteria:
Inclusion Criteria:

          -  women age 18-45 years old

          -  regular menstrual cycles (every 25-35 days)

          -  normal BMI (19-25)

          -  no hormonal contraception in the two menstrual cycles prior to enrollment

        Exclusion Criteria:

          -  pregnancy

          -  pelvic mass
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 1
Clinical trial: A Pilot Study to Explore the Role of Gut Flora in Gout (NCT04224662)

Eligibility criteria:
Inclusion Criteria:

          1. Signed informed consent, demonstrating that the patient understands the procedures
             required for the study and the purpose of the study i. May be signed by parent or
             legal guardian in the case of minor or adult unable to provide consent

          2. Male or female of all ages. (interest is given to children who present with autism or
             Crohn's and whose parents wish to analyze their children's gut flora. Also of interest
             analysis of development of the child's microbiome. In the case of autism, the younger
             the child, the better to correct the neurological problems if an association is found
             between autism and the microbiome)

          3. Diagnosis of Gout by a physician

        Exclusion Criteria:

          1. Refusal to sign informed consent form

          2. History of bariatric surgery, total colectomy with ileorectal anastomosis or
             proctocolectomy.

          3. Postoperative stoma, ostomy, or ileoanal pouch

          4. Participation in any experimental drug protocol within the past 12 weeks

          5. Treatment with total parenteral nutrition
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 1