araag2/NLI4PR huggingface dataset:
Clinical trial: Kinematic-based BoNT-A Injections for Bilateral ET (NCT02551848)

Eligibility criteria:
Inclusion Criteria:

          -  Consenting male and female participants

          -  Diagnosis of 'definite essential tremor' in accordance with the TRIG criteria
             including: ET individuals diagnosed with upper limb tremor in their motor dominant and
             non-dominant hands

          -  Stable ET medication management for the 3 month duration prior to their enrollment in
             the study

          -  Participants who are botulinum toxin naïve for tremor management

          -  Patients will be screened for pregnancy by the physician

        Exclusion Criteria:

          -  History of stroke

          -  Muscle weakness or any related compartmental muscle syndrome

          -  Smoking

          -  History of ALS or Myasthenia Gravis

          -  Offending medications (Lithium, valproate, steroids, amiodarone, beta-adrenergic
             agonists (e.g. salbutamol)

          -  Persons prescribed zonisamide

          -  History of allergic or side effect reaction to botulinum toxin

          -  Contraindications per the Xeomin® drug monograph

          -  Women reporting that they are pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 1
Clinical trial: National Study of Moderate and Severe Von Willebrand Disease in the Netherlands (NCT00510042)

Eligibility criteria:
Inclusion Criteria:

          1. haemorrhagic symptoms or a family history of von Willebrand disease

          2. vWF antigen ≤ 30%, lowest measurement counts and/or vWF activity (vWF:RCo of vWF:CB) ≤
             30%, lowest measurement counts and/or FVIII:C ≤ 40 %, lowest measurement counts

          3. being known in a hemophilia treatment center or if only the diagnose is made in a
             hemophilia treatment center this must be done after 1987

        Exclusion Criteria:

          1. Hemophilia A

          2. Carriership of hemophilia A

          3. No informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Study to Evaluate the Efficacy and Safety of Valoctocogene Roxaparvovec, With Prophylactic Steroids in Hemophilia A (NCT04323098)

Eligibility criteria:
Inclusion Criteria:

          1. Males ≥ 18 years of age with hemophilia A and residual FVIII levels ≤ 1 IU/dL as
             evidenced by medical history, at the time of signing the informed consent.

          2. Must have been on prophylactic hemophilia therapy for at least 12 months prior to
             study entry.

          3. Treated/exposed to FVIII concentrates or cryoprecipitate for a minimum of 150 exposure
             days (EDs).

          4. No previous documented history of a detectable FVIII inhibitor, <0.6 Bethesda Units
             (BU).

          5. Sexually active participants must agree to use an acceptable method of effective
             contraception. Participants must agree to contraception use for at least 12 weeks
             post-infusion.

        Exclusion Criteria:

          1. Detectable pre-existing antibodies to the AAV5 capsid. Up to 25% of subjects may have
             detectable pre-existing AAV5 capsid antibodies, so long as the titer level is below
             the minimum required dilution (< 20).

          2. Any evidence of active infection or any immunosuppressive disorder, including HIV
             infection.

          3. Significant renal dysfunction or liver dysfunction, infection or history of hepatic
             malignancy.

          4. Evidence of any bleeding disorder not related to hemophilia A.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1
Clinical trial: Algorithms for Programming DBS Systems for ET (NCT03984643)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of ET

          -  medication-refractory tremor

          -  VIM-DBS implant (unilateral or bilateral)

          -  7T MRI pre-operative scan under Dr. Harel's IRB (institutional review board) protocol
             (#1210M22183)

          -  Post-operative CT scan

        Exclusion Criteria:

          -  history of musculoskeletal disorders that affect movement of the limbs

          -  other significant neurological disorder

          -  prior history of stereotactic neurosurgery (other than VIM-DBS surgery)

          -  pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 1
Clinical trial: Intra-subject Variability Following Administrations of Activated Recombinant Human Factor VII in Haemophilia Patients in a Non-bleeding State (NCT01562457)

Eligibility criteria:
Inclusion Criteria:

          -  Confirmed diagnosis of congenital haemophilia A or B with a FVIII:C (Activated
             Coagulation Factor VIIa Clotting activity) or FIX:C (Coagulation Factor IX Clotting
             activity) one stage activity, respectively, at less than 5% of normal (based on
             medical records) plus/minus inhibitors (a positive inhibitor status defined as 0.6
             Bethesda units)

          -  Non-bleeding state (i.e. no clinical manifestation of active bleed) at the time of
             administration of trial product

        Exclusion Criteria:

          -  Known or suspected allergy to trial product or any of its components or to related
             products

          -  Known clinically relevant coagulation disorders or insufficiencies other than
             congenital haemophilia A or B

          -  Platelet count below 50,000 platelets/mcL

          -  Received any haemostatic treatment (e.g. Feiba) within the last 7 days prior to
             administration of trial product, except for activated recombinant human factor VII
Male
No healthy subjects accepted to join the trial.
Subject must be at least 16 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1
Clinical trial: The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms (NCT02495311)

Eligibility criteria:
<Women with myoma or adenomyosis>

        Inclusion Criteria:

          1. >20 years old.

          2. Myoma: women with >3 cm uterine myoma

          3. Adenomyosis: women with uterus having several dark area (lacunar areas) in one uterine
             wall or thickening uterine wall

        <The control group>

        Inclusion criteria:

          1. >20 years old.

          2. Women without myoma or adenomyosis

        <Both groups>

        Exclusion Criteria:

          1. The patient has a lower urinary tract infection or acute intestinal inflammation.

          2. Previous surgery for the bladder or urethra.

          3. History of urinary tract stones or tumors.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 1
Clinical trial: Understanding Tick-borne Diseases (NCT03501407)

Eligibility criteria:
Inclusion Criteria for patient with an erythema migrans

          -  Age≥18 years

          -  Erythema migrans

          -  Registered with social security

          -  informed and written consent

        Exclusion Criteria for patient with an erythema migrans

          -  Pregnant women

          -  Immunocompromised patients (undergoing chemotherapy, corticotherapy, or biotherapy)

          -  Chronic inflammatory disease

          -  Systemic disease

        Inclusion Criteria for patient with no-erythema migrans:

          -  Age≥18 years

          -  Confirmed tick bite within the last 6 months prior to the appearance of inflammatory
             joint disease verified via joint imaging (MRI or ultrasound)

          -  and/or cerebrospinal fluid cyto-chemical anomalies (meningitis,albuminocytological
             dissociation)

          -  Registered with social security

          -  informed and written consent

        Exclusion Criteria for patient with no-erythema migrans

          -  Pregnant women

          -  Immunocompromised patients (undergoing chemotherapy, corticotherapy, or biotherapy)

          -  Chronic inflammatory disease

          -  Systemic disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? 1
Clinical trial: Life Plans Intervention Study (NCT03215901)

Eligibility criteria:
Inclusion Criteria:

          -  resides in Africa Health Research Institute demographic surveillance area,
             specifically bounded structures to be visited during the last trimester of the
             surveillance in the "Southern PIPSA" area.

          -  member of a household in the AHRI demographic surveillance

          -  18 to 25 years of age

        Exclusion Criteria:

          -  <18, >25 years

          -  not a member of a household under surveillance

          -  not resident in the surveillance area
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 25 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? 1
Clinical trial: Fertility Assessment in Patients With Klinefelter Syndrome (NCT02461303)

Eligibility criteria:
Inclusion Criteria:

          -  males between the ages of 12 and 25

          -  diagnosed with mosaic or non-mosaic Klinefelter's Syndrome

          -  having bilaterally descended testes

          -  not having had a febrile illness within 3 months of enrollment.

        Exclusion Criteria:

          -  previous treated with gonadotoxic chemotherapeutic or radiation regimen.

          -  psychological, psychiatric, or other conditions which prevent giving fully informed
             consent.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 25 Years

Patient description (medical language): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient description (patient's own words): I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Does the patient match the trial criteria? 1
Clinical trial: Aromatase Inhibitors or GnRH-a for Uterine Adenomyosis (NCT01218581)

Eligibility criteria:
Inclusion Criteria:

          -  Patients included in the study were premenopausal women aged 18-42 years with
             adenomyosis with abnormal uterine bleeding, unexplained infertility, pelvic pain,
             dysmenorrhea, or pressure effect

        Exclusion Criteria:

          -  Excluded subjects included women who had myoma(s) measuring >2 cm, women with uterine
             adenomyoma who were under treatment with any type of hormonal therapy more recently
             than 1 month, and women with a history of major medical problem and/or previous
             medical or surgical treatment for the problem
Female
No healthy subjects accepted to join the trial.



Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 0
Clinical trial: Safety of Somatropin and Induction of Puberty With 17-beta-oestradiol in Girls With Turner Syndrome (NCT01518062)

Eligibility criteria:
Inclusion Criteria:

          -  Turner Syndrome

          -  Well documented growth rate during the previous year

          -  Height below the 50th percentile for the age in Dutch children

          -  Normal thyroid function

        Exclusion Criteria:

          -  Any endocrine or metabolic disorder

          -  Growth failure due to disorders of genitourinary, cardio-pulmonary, gastro-intestinal
             and nervous systems, nutritional/vitamins deficiencies and chondrodysplasias

          -  Patients with hydrocephalus
Female
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 11 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 1