Clinical trial: Diurnal Testosterone Concentration (NCT03091296)

Eligibility criteria:
Inclusion Criteria:

        Men with testosterone deficiency:

          -  Ability to read, write, and understand English

          -  Male sex at birth

          -  Age greater than or equal to 18

          -  Age less than 46

          -  Diagnosed with testosterone deficiency prior to visit 1

          -  Screening testosterone concentration of less than 350 ng/dL

          -  Willing and able to comply with the study protocol

          -  Willing to provide informed consent for this study

          -  No previous exposure to exogenous T unless off therapy for at least 4 weeks

        Men without testosterone deficiency:

          -  Ability to read, write, and understand English

          -  Male sex at birth

          -  Age greater than or equal to 18

          -  Age less than 46

          -  Never diagnosed with testosterone deficiency

          -  Screening testosterone concentration of greater than 350 ng/dL

          -  Willing and able to comply with the study protocol

          -  Willing to provide informed consent for this study

          -  No previous exposure to exogenous T

        Exclusion Criteria:

          -  Previous exposure to exogenous T, clomiphene citrate, or other Selective Estrogen
             Receptor Modulators, unless off therapy for at least 4 weeks

          -  Serious psychiatric disease or uncontrolled medical illness, as suspected from the
             history or clinical examination

          -  Used any sex hormones or steroidal anabolic drug supplements within 28 days before
             screening testosterone collection

          -  Incapable of giving informed consent or complying with the protocol
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 46 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? 1