araag2/NLI4PR huggingface dataset:
Clinical trial: Combined Endoscopic and Laparoscopic Surgery (CELS) for Early Colon Cancer in High Risk Patients (NCT04606992)

Eligibility criteria:
Inclusion Criteria:

          -  UICC stage 1 colon cancer

          -  ASA score min. 3 and/or WHO PS score min. 1

          -  CELS eligible resection

          -  Biopsy show adenocarcinoma or suspicious lesion

          -  No preop chemo or radiotherapy

          -  Accept inclusion

        Exclusion Criteria:

          -  Hereditary cancer

          -  Rectal cancer

          -  Radiation downstaging
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? 1
Clinical trial: Efficacy and Safety of ADVATE Standard Prophylaxis to Hemophilia A (NCT02280265)

Eligibility criteria:
Inclusion Criteria:

          1. Subject has hemophilia A with FVIII≤2 %.

          2. Previously treated patients (PTPs).

          3. Age from 2 to 18 years.

        Exclusion Criteria:

          1. Subject has known hypersensitivity to the active substance or any of the excipients.

          2. Subject has known allergic reaction to mouse or hamster proteins.

          3. Subject has participated in another clinical study involving an investigational
             product (IP) or device within 30 days prior to study enrollment or is scheduled to
             participate in another clinical study involving another FVIII concentrate or device
             during the course of this study.

          4. Subject is planned, or likely to have surgery during the study period.

          5. Subject has end-stage renal failure or evidence of a severe or uncontrolled systemic
             disease as judged by the investigator.

          6. Subject has full-blown Acquired Immuno Deficiency Syndrome (AIDS),determined by
             Cluster Determinant 4+(CD4+) and clinical presentation.

          7. Subject has active hepatic disease (alanine aminotransferase (ALT) and aspartate
             aminotransferase (AST) levels > 5 times the upper limit of normal).

          8. Subject has clinical or laboratory evidence of severe liver impairment including (but
             not limited to) a recent and persistent international normalized ratio (INR)> 1.4,
             and/or the presence of splenomegaly and/or significant spider angioma on physical
             exam, and/or a history of esophageal hemorrhage or documented esophageal varices.

          9. The subject in the opinion of the investigator is unable or unwilling to comply with
             study protocol

         10. Subject is a family member of the investigator or site staff
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Study of a Dietary Supplement for Reflux During Sleep (NCT02274636)

Eligibility criteria:
Inclusion Criteria:

          1. A medical diagnosis of GERD

          2. Awakening with a taste of refluxed stomach acid in the mouth

          3. Heartburn during sleep

          4. Voice hoarseness upon awakening

          5. Antacid use at night

          6. Dry mouth at bedtime or during the night

          7. Experience difficulty chewing, swallowing, and speaking because of dry mouth

        Exclusion Criteria:

          1. Under 18

          2. Prior history of any of these conditions:

               1. coronary artery disease

               2. gallbladder disease

               3. gastric or esophageal cancer

               4. peptic ulcer disease

               5. esophagitis, whether eosinophilic, infectious, or pill based

               6. esophageal motility disorders

          3. A history of thoracic, esophageal, or gastric surgery

          4. No medical examination in the prior year
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 1
Clinical trial: Febuxostat-Controlled, Double-Blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout (NCT03372200)

Eligibility criteria:
Inclusion Criteria:

          -  Serum urate level:

               -  >= 7.0mg/dL in patients with gouty nodule or with history of gout, or >= 8.0mg/dL
                  in patients with hypertension, diabetes or metabolic syndrome, or >= 9.0mg/dL

          -  Disease type in the classification of hyperuricemia: Uric acid-underexcretion type or
             mixed type

          -  Outpatients

        Exclusion Criteria:

          -  Gouty arthritis within 14 days before randomized allocation

          -  Secondary hyperuricemia

          -  HbA1c: >= 8.4%

          -  Clinically significant cardiac, hepatic, renal, hematologic or endocrine disease

          -  Kidney calculi or clinically significant urinary calculi

          -  AST: >= 100 IU/L or ALT: >= 100 IU/L

          -  eGFR: < 30 mL/min/1.73m^2

          -  Systolic blood pressure: >= 180 mmHg or diastolic blood pressure: >= 110 mmHg
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 0
Clinical trial: A Clinical Evaluation of COVID-19 Rapid Point of Care Antigen Tests (NCT04568356)

Eligibility criteria:
Inclusion Criteria:

          -  Provision of verbal informed consent form

          -  Subject is suspected case of COVID-19 by clinical criteria a patient with acute
             respiratory tract infection (sudden onset of at least one of the following: cough,
             fever, shortness of breath, fatigue, decreased appetite, myalgia)

          -  No other etiology that fully explains the clinical presentation

          -  With or without a history of close contact with a confirmed or probable COVID-19 case
             in the last 14 days prior to onset of symptoms.

          -  Subject is an appropriate candidate for Nasopharyngeal sample collection

          -  Subject is willing to provide nasopharyngeal swab and saliva samples

        Exclusion Criteria:

        • Individuals who present to ER with 10 or greater days of COVID-19 Related Symptoms,
        (Fever, Cough, Fatigue, Decreased Appetite, Shortness of Breath, Myalgia) or
        post-defervescence and/or convalescence
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: New Moves - Obesity Prevention Among Adolescent Girls (NCT00250497)

Eligibility criteria:
Inclusion Criteria:

          -  High school girls

          -  Low levels of physical activity - defined as being in precontemplation, contemplation,
             or preparation stages of change for physical activity with activity levels at, or
             below, 30 minutes per day/three days per week outside of school physical education
             class

          -  Priority will be given to girls with a body mass index (BMI) greater than or equal to
             the 75th percentile for age and gender

        Exclusion Criteria:

          -  BMI less than the 25th percentile for age and gender
Female
Accepts Healthy Volunteers
Subject must be at least 14 Years old.
Subject must be at most 19 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 0
Clinical trial: Study to Investigate Adrenal Crisis (Six-year Follow-up) (NCT03499990)

Eligibility criteria:
Inclusion Criteria:

          -  Chronic primary or secondary adrenal insufficiency; hormone replacement therapy with
             glucocorticoids (hydrocortisone, cortisone acetat, prednisone or prednisolone)

          -  Written informed consent

        Exclusion Criteria:

          -  Adrenal insufficiency due to adrenocortical carcinoma

          -  Adrenal insufficiency due to long-term pharmacological glucocorticoid treatment

          -  Glucocorticoid doses above 7.5 mg prednisolone equivalent for other reasons than
             adrenal insufficiency

          -  Age younger than 18 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? 0
Clinical trial: Clinical and Genetic Studies in Families With Myopia and Related Diseases (NCT00272376)

Eligibility criteria:
-  INCLUSION CRITERIA:

               1. Individuals or family members of individuals with myopia, either congenital,
                  childhood, or older.

               2. Adults must be capable of providing their own consent.

               3. All subjects must be able to cooperate with study examination and phlebotomy.

               4. Older than 4 years of age.

        EXCLUSION CRITERIA:

          1. Diseases, infections, or trauma that mimic primary myopia.

          2. Children requiring sedation for study procedures.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.


Patient description (medical language): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient description (patient's own words): I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Does the patient match the trial criteria? 1
Clinical trial: A Study of LY3202626 on Disease Progression in Participants With Mild Alzheimer's Disease Dementia (NCT02791191)

Eligibility criteria:
Inclusion Criteria:

          -  Present with mild AD dementia based on the National Institute on Aging (NIA) and the
             Alzheimer's Association (AA) disease diagnostic criteria as determined by a qualified
             clinician approved by the Sponsor or designee.

          -  Mini-Mental State Examination score of 20 to 26 inclusive at screening visit.

          -  Has a florbetapir PET scan consistent with the presence of amyloid pathology at
             screening.

        Exclusion Criteria:

          -  Significant neurological disease affecting the central nervous system (CNS), other
             than AD, that may affect cognition or ability to complete the study, including but not
             limited to, other dementias, serious infection of the brain, Parkinson's disease,
             multiple concussions, or epilepsy or recurrent seizures (except febrile childhood
             seizures).

          -  Ocular pathology that significantly limits ability to reliably evaluate vision or the
             retina.

          -  Use of strong inducers of cytochrome P450 3A (CYP3A).

          -  Sensitivity to florbetapir or ¹⁸F-AV-1451.

          -  Contraindication to MRI or PET or poor venous access for blood draws.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 0