araag2/NLI4PR huggingface dataset:
Clinical trial: Idiopathic Pulmonary Fibrosis and Serum Bank (NCT04016168)

Eligibility criteria:
Inclusion Criteria:

          -  Patients seen on an outpatient basis and in stable or acute condition

          -  Patient over 18 years of age.

          -  The inclusion criteria will be those edited by the American Thoracic Society (ATS) and
             the European Respiratory Society (ERS) to diagnosis IPF

        Exclusion Criteria:

          -  Patients who are unable or unwilling to sign the consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? 1
Clinical trial: The Plastic Covering Method for Self-gripping Mesh Placement in Laparoscopic Inguinal Hernia Repair (NCT04394338)

Eligibility criteria:
Inclusion Criteria:

          -  Elective laparoscopic inguinal hernia repair

        Exclusion Criteria:

          -  Rejected or withdrawn consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior (NCT04805515)

Eligibility criteria:
Inclusion Criteria:

          -  US resident age 18+

          -  Member of the partnering consumer research panel conducting the survey

          -  Non-smokers and tobacco cigarette smokers

        Exclusion Criteria:

          -  Age less than 18

          -  Not a member of the partnering consumer research panel conducting the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? 1
Clinical trial: A Phase I Study to Assess the Effect of Itraconazole and Rifampicin on Pharmacokinetics Profile of BPI-7711 (NCT04135833)

Eligibility criteria:
Inclusion Criteria:

          -  Male, aged from 18 to 45 years

          -  BMI from 18.5 to 28.0 kg/m2

          -  Medical history, vital signs, physical examination and lab tests are normal or
             abnormal without clinical significance

        Exclusion Criteria:

          -  Subjects with clinical significant diseases

          -  Subjects with allergic disease history

          -  Subjects with gastrointestinal disease history that can affect study drug absorption

          -  Subjects with drug abuse history
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? 1
Clinical trial: A Pilot Efficacy and Safety Study of ST101 in Essential Tremor (NCT01332695)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of definite or probable essential tremor (ET) as defined by the Tremor
             Investigational Group with involvement of the hands and arms of at least 2 years
             duration

          -  Tremor severity score of >/= 2 in at least one upper extremity on the
             Fahn-Tolosa-Marin Tremor Rating Scale

          -  Subject who is accessible by telephone

          -  Subject who can comply with study visits, study drug compliance, and study procedures.

        Exclusion Criteria:

          -  Subject whose tremor is adequately controlled on a current treatment

          -  Subject who is pregnant, plans to become pregnant during the study or within 2 months
             of completing the study or who is presently lactating or breast-feeding

          -  Subject with other medical conditions that may cause or explain subject's tremor

          -  Subject with a recent history of hematologic/oncologic disorders

          -  Subject taking medication(s) that might produce tremor or interfere with the
             evaluation of tremor

          -  Subject who has had surgical intervention for their tremor in the past (e.g., ablative
             thalamotomy or gamma knife thalamotomy), or has had a botulinum toxin injection in the
             6 months prior to screening
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 1
Clinical trial: Open-Label Placebo Treatment of Women With Premenstrual Syndrome (NCT03547661)

Eligibility criteria:
Inclusion Criteria:

          -  Moderate to severe PMS

          -  Between 18 and 45 years of age

          -  A regular menstrual cycle, i.e., max. +/- 3 days of difference of cycle range

          -  Menstrual cycle range not longer than 31 or shorter than 24 days

          -  Participants have a general practioner or gynaecologist to consult

          -  At least one premenstrual symptom causes the desire for a PMS treatment

        Exclusion Criteria:

          -  Brest feeding at the moment or during the last three months

          -  Pregnancy

          -  Failing menstruation onset in the course of two consecutive menstrual cycles

          -  An essential mental or somatic disease

          -  Drug or massive alcohol intake or of other psychoactive substances

          -  Uptake of a new medication within the last 30 days

          -  Menopause, premenopausal strain or amenorrhoea

          -  Allergy of one of the ingredients of the placebo dragées (P-Dragees rosa Lichtenstein)

          -  Women who are surgically sterilised, hysterectomised, or ovariectomised

          -  BMI above 30

          -  Actual or recent participation in psychotherapy due to premenstrual symptoms

          -  Parallel participation in another study with investigational drugs or participation in
             another PMS study within the last three months
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Nottingham Osteoarthritis Biomarker Study 2011 (NCT01495455)

Eligibility criteria:
Inclusion Criteria:

        All participants:

          -  Be able to provide written informed consent

          -  Aged 30 and over

        Knee OA patients:

        • Radiographic signs of OA - that is definite joint space narrowing plus osteophyte in at
        least one compartment of the knee

        Normal controls:

          -  No knee pain

          -  No clinical or radiographic changes of knee OA
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 30 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 1
Clinical trial: The Nitazoxanide Plus Atazanavir for COVID-19 Study (NCT04459286)

Eligibility criteria:
Inclusion Criteria:

          -  Willingness and ability to provide written informed consent

          -  At least 18 and not more than 75 years of age at study entry

          -  SARS-CoV-2 infection confirmed by PCR test within 4 days before randomization

          -  Currently symptomatic (fever or chills, cough, myalgia, sore throat, shortness of
             breath, or new onset of anosmia or ageusia) and at COVID-19 isolation and treatment
             centre

        Exclusion Criteria:

          -  Inability to take orally administered medication or food

          -  Known hypersensitivity to study medication

          -  Pregnant or lactating (unless practicing exclusive replacement feeding for the entire
             study duration)

          -  Participation in any other interventional trial for COVID-19 (observational study
             co-enrollment allowed)

          -  Concurrent treatment with other agents with actual or possible direct-acting antiviral
             activity against SARS-CoV-2 less than 24 hours prior to study drug dosing

          -  Concurrent use of agents with known or uncertain interaction with study drugs,
             including ritonavir

          -  Requiring mechanical ventilation at screening

          -  Alanine Aminotransferase (ALT) or aspartate aminotransferase (AST) above 5 times upper
             limit of normal (ULN)

          -  Creatinine clearance below 50 mL/min using the Cockcroft-Gault formula for
             participants above 18 years of age
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: Liquid Biopsies for the Personalized Management of Patients With Hereditary Diffuse Gastric Cancer (NCT04253106)

Eligibility criteria:
Inclusion Criteria:

        Case:

          -  Patient>18 years old

          -  CDH1 or CTNNA1 germline pathogenic variant.

          -  No history of diffuse gastric cancer.

          -  French social security.

          -  Ability to understand and willingness to sign a written informed consent document.

        Volunteers:

          -  Patients > 18years old

          -  Patients with no oncological history

        Exclusion Criteria: for both arms

          -  Patients with cancer being treated

          -  Patients with metastatic cancer

          -  Medical contraindication to general anesthesia or FOGD (bleeding disorder, pregnant
             women )

          -  Patients under guardianship or curator
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? 0
Clinical trial: Value of Cabergoline and Low Dose Aspirin in Poor Responders Undergoing ICSI-ET With GnRH Agonist Flare-Up-Protocol (NCT03263299)

Eligibility criteria:
Inclusion Criteria:

          1. Patients with a history of one or more failed IVF cycles with three or less retrieved
             oocytes

          2. No age limitation

          3. Patients with an inadequate ovarian response in previous cycle

          4. Low estradiol (E2) levels in response to ovarian stimulation in previous cycle

          5. Lower number of retrieved oocytes in previous trials.

        Exclusion Criteria:

          1. Severe male factor (azospermia)

          2. Hydrosalpinx

          3. History of endometriosis

          4. Endocrine or metabolic disorders

          5. Follicle stimulating hormone (FSH) level > 15 mIU.

          6. Antimullerian hormone (AMH)< 0.5 ng/ml

          7. Any uterine causes of infertility e.g. septate uterus
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0