Clinical trial: Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort: The 4F Study (NCT03414411)

Eligibility criteria:
Inclusion Criteria:

          -  Ability to speak English (fluency)

          -  Willing to provide information for >1 contact person likely to know their whereabouts
             for follow-up.

          -  Documented HIV antibody by ELISA confirmed by Western Blot or current HIV viral load
             greater than 10,000 (in any medical record); or HIV antibody by 4th generation ELISA
             confirmed by a "Multi-Spot" rapid test for discrimination of HIV-1 from HIV-2
             infection and, if necessary in the case of discordant results, nucleic acid testing
             (NAT) for HIV-1; or any other confirmatory pathway approved by the Massachusetts
             Department of Public Health, U.S. Centers for Disease Control and Prevention or BMC
             Center for Infectious Diseases.

          -  Any past 12 month use of illicit drugs, marijuana (not recommended by a healthcare
             provider), or nonmedical use of prescription medications (assessed using the Tobacco,
             Alcohol, Prescription Medication and Other Substances (TAPS) Tool); OR past 12 month
             alcohol use with positive AUDIT-C score (≥3 for females and ≥4 for males)

          -  OR, an existing participant in the Boston ARCH Cohort

        Exclusion Criteria:

          -  Inability to consent or understand interview (determined by trained research
             assistant)

          -  Under age 18

          -  Plans to leave Boston area in <1 year
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? 1