araag2/NLI4PR huggingface dataset:
Clinical trial: Speckle Tracking Echocardiography Analysis of Left Ventricular Myocardium After Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy (NCT04777188)

Eligibility criteria:
Inclusion Criteria:

          1. Patients with symptoms that limit daily activities (New York Heart Association
             functional class >II, exercise-induced syncope) despite adequate medical treatment or
             when medical treatment is not tolerated

          2. Patients with a peak LVOT gradient≥50 mm Hg

        Exclusion Criteria:

          1. Those with a peak instantaneous Doppler LVOT gradient of <50 mm Hg

          2. Those with an indication for septal reduction therapy and other lesions requiring
             surgical intervention (e.g., mitral valve repair/replacement and papillary muscle
             intervention)

          3. Those with end-stage heart failure；and those the echocardialology image quality is not
             clear enough for strain analysis.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? 1
Clinical trial: Oral Testosterone for the Treatment of Hypogonadism (NCT01717768)

Eligibility criteria:
Inclusion Criteria:

          -  Prior documentation of a diagnosis of hypogonadism as evidenced by a screening serum
             testosterone < 300 ng/dL (based on the average of 2 morning samples taken at least 1
             week apart)

          -  Men over the age of 18 years with a body mass index (BMI) < 39.0 kg/m2 and weighing ≥
             55 kg

          -  Hemoglobin levels at screening and baseline > 12.5 g/dL

          -  Testosterone treatment not contraindicated

          -  No evidence of suspected reversible hypogonadism

          -  Willing to abstain from current treatment for hypogonadism in accordance with approved
             labeling to facilitate an appropriate washout period before study participation (for
             nondepot formulations of testosterone only)

          -  Understands the requirements of the study and voluntarily consents to participate in
             the study

        Exclusion Criteria:

        -
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? 1
Clinical trial: Database of All Patients Who Have Undergone Pulmonary Function Testing at Singapore General Hospital (NCT01601288)

Eligibility criteria:
Inclusion Criteria:

        1) All patients who have undergone pulmonary function testing at the Singapore General
        Hospital pulmonary function laboratory
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? 0
Clinical trial: A Study of AC-201 Controlled-Release Tablet (CR Tablet) in Patients With Gout (NCT02287818)

Eligibility criteria:
Inclusion Criteria:

          1. Male or female age 20 to 65 years, inclusive.

          2. Meets ≥6 of the 12 American College of Rheumatology preliminary criteria (1977) for
             the classification of acute arthritis of primary gout (Appendix 2), OR have proven
             tophus or documented monosodium urate (MSU) crystals in the joint fluid.

          3. Serum uric acid ≥7.5 mg/dL and ≤10 mg/dL at screening with ≥1 gouty arthritis flare
             within one year prior to screening, OR serum uric acid ≥9 mg/dL and ≤10 mg/dL at
             screening with or without prior gout flares.

        Exclusion Criteria:

          1. Use of allopurinol, febuxostat, benzbromarone, probenecid, or sulfinpyrazone within 2
             weeks prior to screening.

          2. Occurrence of a gouty arthritis flare within 1 week prior to screening or during the
             screening period through baseline.

          3. Use of colchicine within 1 week prior to screening.

          4. Use of Glucocorticoids, NSAIDs or COX-2 inhibitors within 1 week prior to screening.

          5. Allergy, contraindication, or intolerance to febuxostat.

          6. Severe renal impairment.

          7. Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) concentration >2
             times the upper limit of laboratory normal range (>2x ULN) at screening.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 0
Clinical trial: Evaluation of Influenza A/H3N2 Vaccine in Patients With Rheumatologic Diseases (NCT03540823)

Eligibility criteria:
Inclusion Criteria:

          -  Adult and juvenile systemic lupus erythematosus (SLE) and juvenile SLE patients
             according to the ACR classification criteria aged ≥ 18 years for adults and aged ≥ 9
             and <18 years for the juvenile group

          -  Patients with primary Sjögren's Syndrome (SSp) (classification criteria of the
             European Study Group on Diagnostic Criteria for Sjögren's Syndrome) aged ≥ 18 years

        Exclusion Criteria:

          1. History of anaphylactic response to vaccine components or egg allergy

          2. Moderate or severe acute febrile illness

          3. Guillain-Barré syndrome, decompensated heart failure (class III or IV), demyelinating
             disease.

          4. History of live virus vaccine up to 4 weeks before, virus vaccine inactivated up to 2
             weeks prior, influenza vaccine up to 6 months prior to study.

          5. History of having received blood products up to 6 months prior to the study.

          6. Individuals who do not agree to participate in the study and / or whose parents do not
             agree to participate in the study.

          7. Inpatients

          8. Patients with severe conditions requiring hospitalization
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 9 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1
Clinical trial: The Effects of Neuromuscular Exercises Training on Physical Activity, Functionality and Balance in Knee Osteoarthritis (NCT03470090)

Eligibility criteria:
Inclusion Criteria:

          -  patients with knee osteoarthritis,

          -  individuals without a physical disability,

          -  person in an age range 35- 65 years,

          -  Having no any knee surgeon,

          -  Mentally that is sufficient to make assessments,

          -  Who want to be involved voluntary work,

          -  Ability to adjust the training program

          -  Individuals who received informed consent

        Exclusion Criteria:

          -  Individuals who do not allow mental evaluation

          -  Individuals who do not want to be involved in voluntary work.

          -  Clinical study refused to participate in.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 35 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Effect on the Quality of Life of a Therapeutic Education Program in Patients With Marfan Syndrome (NCT04731493)

Eligibility criteria:
Inclusion Criteria:

          -  Patient aged between 7 and 25 years old with Marfan Syndrome or related according to
             Ghent criteria

          -  For minors, no oral opposition from the holders of parental authority and consent of
             the minor.

          -  For adults, no oral opposition collected

          -  Patient affiliated to a social security scheme or equivalent

        Exclusion Criteria:

          -  Inability of the patient to understand the content of the TEP sessions or the
             questionnaire about quality of life (non-French speaking, severe intellectual
             disability)

          -  Patient who has already participated in a TEP session for his pathology.

          -  Protected adult: patient under legal guardianship or curator protection
No condition on gender to be admitted to the trial.

Subject must be at least 7 Years old.
Subject must be at most 25 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? 1
Clinical trial: 1-Octanol to Treat Essential Tremor (NCT00016679)

Eligibility criteria:
INCLUSION CRITERIA:

        Patients with essential tremor with a history or ethanol responsiveness.

        Patients must be off any medications used to treat essential tremor such as mysoline or
        propranalol for at least 2 weeks.

        Patients must withhold ethanol and caffeine from 24 hours prior to starting the study until
        study termination (10 days).

        EXCLUSION CRITERIA:

        Patients with abnormalities on neurologic exam other than tremor.

        Patients with a history of chronic alcohol dependence.

        Patients with chronic medical conditions such as renal failure, hepatic failure and chronic
        lung disease.

        Patients on other chronic medications that cannot be temporarily discontinued for the
        length of the study (10 days).

        Patients, who for moral or religious reasons do not wish to take a potentially intoxicating
        drug.

        Patients with abnormalities on their baseline screening laboratory tests.

        Women who are pregnant or lactating.

        People of Asian decent who may differ pharmocogenetically with respect to alcohol and
        aldehyde dehydrogenase and may have increased sensitivity to alcohols and their metabolites
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 1
Clinical trial: Confocal Microscopy and Lacrimal Gland in Sjogren's Syndrome (NCT00920179)

Eligibility criteria:
Inclusion Criteria:

          -  The Sjögren's syndrome diagnosis was made according to the revised American-European
             consensus criteria.

          -  Briefly, the patients had to have ocular and oral symptoms of dryness,

          -  clinically diagnosed dry eye and dry mouth disease,

          -  serum rheumatoid factor and antinuclear antibody levels ≥1:160,

          -  positive serology for anti SS-A or anti SS-B antibodies,

          -  labial salivary gland inflammatory infiltration focus score ≥2 and consents for
             lacrimal gland biopsy to be included into this study.

        Exclusion Criteria:

          -  Patients with any history of ocular surgery including punctal occlusion,

          -  other ocular or systemic disease

          -  or a history of topical/ systemic drug use or contact lens wear or

          -  other systemic disorders that would cause dry eyes or that would alter the ocular
             surface.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1