araag2/NLI4PR huggingface dataset:
Clinical trial: Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion (NCT00166894)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of pleural effusion

          -  Pleural effusion proved by chest sonography

        Exclusion Criteria:

          -  Conditions for which thoracentesis are contraindicated

          -  Pregnancy
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? 1
Clinical trial: Virtual Reality in Individuals With Duchenne Muscular Dystrophy (NCT03002298)

Eligibility criteria:
Inclusion Criteria:

          -  medical diagnosis of Duchenne Muscular Dystrophy confirmed by molecular method and/or
             protein expression in skeletal muscle;

          -  signing of an informed consent form from the individual or person legally responsible.

        Exclusion Criteria:

          -  presence of associated comorbidities;

          -  inability in comprehension of the task.
Male
Accepts Healthy Volunteers
Subject must be at least 12 Years old.
Subject must be at most 32 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 0
Clinical trial: Short-term Impact of Cyplexinol® on Self-reported Joint Pain (NCT04764110)

Eligibility criteria:
Inclusion Criteria:

          -  body mass index (BMI) between 18-29.9 kg/m2 (not obese)

          -  no consumption of alcohol-containing beverages within 48 hours of testing

          -  experiencing self-reported joint pain with a minimum pain rating of 3/10 for at least
             the past 30 days

          -  engaged in structured exercise 2 or more days per week for the past 6 months or longer

          -  a negative verbal pre-study drug screen (alcohol abuse, amphetamines, benzodiazepines,
             cocaine, opioids, phencyclidine, barbiturates, cotinine), no history of use of illicit
             drugs or other substances of abuse within 12 months of the screening visit

        Exclusion Criteria:

          -  pregnant

          -  tobacco user

          -  active infection or illness of any kind

          -  rheumatic or osteoarthritic diagnosis

          -  Using anti-inflammatory medicines, pain medications, or dietary supplements (or not
             willing to cease for one-month prior to participation and throughout study)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 1
Clinical trial: Positive Pressure Treadmill Walking for Individuals With Knee Pathology (NCT04747444)

Eligibility criteria:
Inclusion Criteria:

          -  Age > 50 years

          -  Diagnosis of unilateral or bilateral knee osteoarthritis

          -  Clinical AND/OR radiographic knee osteoarthritis.

        Exclusion Criteria:

          -  Age < 50 years

          -  History of lower extremity total joint arthroplasty

          -  Current cardiovascular disease or hypertension that is uncontrolled

          -  History of neurological disorder that effects lower extremity function (i.e., stroke,
             peripheral neuropathy, multiple sclerosis, Parkinson's disease)

          -  Current ankle or hip pain

          -  Currently pregnant for female participants

          -  Weight over 400 lbs (181.4 kg), height less than 4'8" (142 cm) or over 6'4" (193 cm),
             18.5" (47 cm) hip width, or 58" (147 cm) hip circumference
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 0
Clinical trial: Propranolol and Botulinum Toxin for Essential Vocal Tremor (NCT02111369)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of essential voice tremor

          -  Patients who have received or are planning to receive botulinum toxin injections for
             essential voice tremor

          -  Patients who give informed consent to be contacted for research

        Exclusion Criteria:

          -  Patients who are already on a beta blocker

          -  Patients who suffer from hypotension, bradycardia, or otherwise have a medical
             contraindication to beta blocker therapy (eg. moderate to severe bronchial asthma)

        If the patient has received botulinum toxin injections for EVT previously, a three-month
        washout period is necessary before participation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 45 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 0
Clinical trial: Normative Database for Pattern Electroretinogram (PERG) and Flash Electroretinogram (FERG) (NCT02609204)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy volunteers age 18 years

          -  older with normal eye exam

        Exclusion Criteria:

          -  spherical refraction outside + 5.0 Diopters and cylinder correction outside + 3.0
             Diopters.

          -  IOP (intraocular pressure) ≥ 22 mm Hg (millimeters of mercury)

          -  history of any type of glaucoma in either eye.

          -  Intraocular surgery in study eye (except non-complicated cataract or refractive
             surgery performed more than 1 year before enrollment).

          -  Best corrected visual acuity worse than 20/40.

          -  Evidence of diabetic retinopathy, diabetic macular edema, or other vitreo-retinal
             disease in either eye.

          -  Evidence of optic nerve, macula and/or retinal nerve fiber layer abnormality in either
             eye.

          -  Evidence of reproducible (false positives, fixation losses and false negatives ≤ 25%
             with no observable testing artifacts).

          -  Standard Automatic Perimetry (SAP) abnormality in either eye, defined as Pattern
             Standard Deviation < 5% level, and/or abnormal Glaucoma Hemifield test result, and/or
             any other pattern of loss which is consistent with a neurologic and/or ocular disease.

          -  Current or recent (within the past 30 days) use of an agent (by any administering
             method) known to affect visual function.

          -  Inability to obtain reliable PERG/FERG (Pattern Electroretinogram/Flash
             Electroretinogram) results.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient description (patient's own words): I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Does the patient match the trial criteria? 0
Clinical trial: Clinical Performance Evaluation of KnowNow SARS-CoV-2 Test for the Detection of COVID-19 Antigen (NCT04733170)

Eligibility criteria:
Inclusion Criteria:

          1. Male or female aged 18 years or over (or age of adult consent in some states within
             the United States).

          2. Suspected COVID-19 infection and / or presenting with at least 1 recognised symptom
             Fever or chills. ie: Cough. Shortness of breath or difficulty breathing, fatigue,
             muscle or body aches, headache, new loss of taste or smell, sore throat

          3. Be willing and able to comply with study procedures.

          4. Be able to give written informed consent.

        Exclusion Criteria:

          1. Inability to give written informed consent.

          2. Vaccinated against SARS-CoV-2

          3. Adults unable to undertake the requirements of the nasopharyngeal or saliva sample
             collection for physical or psychological reasons

          4. Subjects with other significant disease, condition, or at the Clinician's discretion.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: Oval-8 Splinting Versus Standardized Treatment With Tee Pee or Forearm Based Thumb Spica Splinting (NCT02266095)

Eligibility criteria:
Inclusion Criteria:

          -  Carpometacarpal (CMC) osteoarthritis

          -  greater than or equal to 35 degrees of passive thumb interphalangeal (IP) joint
             hyperextension on physical exam

        Exclusion Criteria:

          -  History of hand surgery to affected hand

          -  Prior surgical treatment for thumb carpometacarpal (CMC) osteoarthritis.

          -  Patients with diagnosis of an autoimmune arthritis and post traumatic arthritis
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 0
Clinical trial: Effect of Simethicone on Eustachian Tube Dysfunction (NCT01312038)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 to 50 years

          -  Healthy subjects other than current upper respiratory tract infection ("cold")

          -  Jackson Score of 6 on screening

          -  Subject reports symptom onset within 4 days of entry visit

          -  Unilateral or bilateral middle-ear pressure <-50 mmH2O

        Exclusion Criteria:

          -  Otoscopic diagnosis of unilateral or bilateral otitis media

          -  Presence of tympanostomy tubes or tympanic membrane perforations bilaterally

          -  Asthma or any chronic medical disease or condition

          -  Use of an "over the counter" medicine within 24 hours of study or prescription within
             4 weeks of the study day (except birth control)

          -  Use of an experimental drug within 3 months of study

          -  An unusual or allergic reaction to simethicone, food dyes, or preservatives

          -  Pregnancy or breast feeding

          -  Ear surgery other than tympanostomy tube insertion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? 1
Clinical trial: Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder (NCT01401413)

Eligibility criteria:
Inclusion Criteria:

          -  Meets criteria for RBD as determined by screening PSG's

          -  steady bed partner for completion of RBD questionnaire

        Exclusion Criteria:

          -  Hepatic impairment

          -  RBD associated with narcolepsy

          -  use of fluvoxamine, rifampin, fluconazole or ketoconazole

          -  current alcohol or drug abuse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? 0