araag2/NLI4PR huggingface dataset:
Clinical trial: Study of Diclofenac Capsules to Treat Osteoarthritis Pain (NCT01461369)

Eligibility criteria:
Inclusion Criteria:

          -  Primary diagnosis of Functional Class I-III OA of the hip or knee with documented
             osteoarthritis flare at baseline

          -  Chronic user of nonsteroidal anti-inflammatory drugs (NSAIDs) and/or acetaminophen for
             OA pain

          -  Discontinued all analgesic therapy at Screening

          -  For women of child-bearing potential: a woman who is not pregnant and not nursing, and
             who is practicing an acceptable method of birth control

        Exclusion Criteria:

          -  History of allergic reaction or clinically significant intolerance to acetaminophen,
             aspirin, or any NSAIDS, including diclofenac

          -  Requires continuous use of opioid or opioid combination products to control OA pain of
             the knee or hip

          -  Clinically significant unstable cardiac, respiratory, neurological, immunological,
             hematological, or renal disease

          -  Significant difficulties swallowing capsules or unable to tolerate oral medication

          -  Previous participation in another clinical study of Diclofenac Capsules or received
             any investigational drug or device or investigational therapy within 30 days before
             Screening.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: A Double-blind, Placebo-controlled Clinical Trial of Fluvoxamine for Symptomatic Individuals With COVID-19 Infection (NCT04342663)

Eligibility criteria:
Inclusion Criteria:

          1. men and woman age 18 and older;

          2. Not hospitalized;

          3. Has recently tested SARS-CoV-2 (COVID-19 virus) positive.

          4. Currently symptomatic with one or more of one or more of the following symptoms:
             fever, cough, myalgia, mild dyspnea, diarrhea, vomiting, anosmia (inability to smell),
             ageusia (inability to taste), sore throat.

          5. Able to provide informed consent.

        Exclusion Criteria:

          1. Illness severe enough to require hospitalization or already meeting study's primary
             endpoint for clinical worsening.

          2. Unstable medical comorbidities including, but not limited to: Severe underlying lung
             disease (COPD on home oxygen, interstitial lung disease, pulmonary hypertension),
             decompensated cirrhosis, Congestive heart failure (stage 3 or 4 per patient report
             and/or medical records).

          3. Immunocompromised (solid organ transplant, BMT, AIDS, on biologics and/or high dose
             steroids (>20mg prednisone per day)

          4. Unable to provide informed consent (eg moderate-severe dementia diagnosis)

          5. Unable to perform the study procedures
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: A Phase 1/2 Study of Ramucirumab Plus Nivolumab in Participants With Gastric or GEJ Cancer (NCT02999295)

Eligibility criteria:
Inclusion Criteria:

          -  Advanced or recurrent unresectable gastric or GEJ cancer

          -  Histologically confirmed adenocarcinoma (papillary adenocarcinoma, tubular
             adenocarcinoma or poorly differentiated adenocarcinoma), signet-ring cell carcinoma,
             mucinous adenocarcinoma or hepatoid adnocarcinoma

          -  Patients with normal oral intake

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

          -  Patients who have measurable target lesion

          -  Patients has a refractory or intolerant pretreatment by pyrimidine fluoride anticancer
             agent and platinum-based anticancer agent

          -  Patients with adequate organ function

          -  Patients with no pretreatment history including ramucirumab, nivolumab or other
             therapies targeting control of T cells

          -  Patients with written informed consent

        Exclusion Criteria:

          -  Patients have double cancer

          -  Patients have infection required systemic therapy

          -  Known central vervous system (CNS) metastasis

          -  Patients with history of pneumonitis or pulmonary fibrosis

          -  Patients with history of serious anaphylaxis induced by antibody preparation

          -  Patients who have known active autoimmune disease or history of chronic recurrent
             autoimmune disease

          -  Female who is pregnant, lactating or suspected pregnancy

          -  Patients with psychosis or dementia to interfere to obtain informed consent
             appropriately
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? 1
Clinical trial: Feasibility Assessment of the Blood Pressure Imager, a Continuous Blood Pressure Monitor (NCT03128944)

Eligibility criteria:
Inclusion Criteria:

          -  Tests will be performed with any adult volunteer who is physically and mentally able
             to perform the experimental tasks.

        Exclusion Criteria:

          -  We will restrict the experiments to adult volunteers who are physically and mentally
             able to consent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? 1
Clinical trial: Statistical Basis for Hemochromatosis Screening (NCT00005559)

Eligibility criteria:
No eligibility criteria
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 100 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? 1
Clinical trial: A Trial on Treatments of Hirschsprung Allied Disease (NCT02212054)

Eligibility criteria:
Inclusion Criteria:

          -  hard or firm stools for twice or less per week

          -  a predicting score of less than 5 refer to literature: Wu, X.J., et al., A new
             diagnostic scoring system to differentiate Hirschsprung's disease from Hirschsprung's
             disease-allied disorders in patients with suspected intestinal dysganglionosis. Int J
             Colorectal Dis, 2013. 28(5): p. 689-96

        Exclusion Criteria:

          -  functional constipation

          -  a predicting score of more than 5 refer to literature: Wu, X.J., et al., A new
             diagnostic scoring system to differentiate Hirschsprung's disease from Hirschsprung's
             disease-allied disorders in patients with suspected intestinal dysganglionosis. Int J
             Colorectal Dis, 2013. 28(5): p. 689-96
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.
Subject must be at most 14 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? 0
Clinical trial: Duchenne Muscular Dystrophy Clinical Trial (NCT01874275)

Eligibility criteria:
Inclusion Criteria:

          -  Participants must have Duchenne Muscular Dystrophy diagnosis as confirmed by licensed
             physician, wheelchair bound, & age 8 - 20 years old.

        Exclusion Criteria:

          -  Active cancer in the area of application of the treatment, infection, skin infection,
             pregnancy, thrombophlebitis, pacemaker, amputation of any part of feet or hands,
             taking steroids. In addition, the participant may not be in any other clinical trial
             during the time they are in this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 20 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 1
Clinical trial: Response Surface Pathway Design With Two Interventional- and One Response Variable in Estimating Minimum Efficacy Dose (NCT03568825)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosed Gastroesophigual Reflux Disease

          -  Known effect of anti-reflux medication

        Exclusion Criteria:

          -  Hiatus hernia ≥5 cm

          -  gastric ulcer

          -  cancer

          -  uncontrolled bacterial, viral, fungal or parasite infection.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 1
Clinical trial: Safety and Biomarker Study of EPI-589 in Participants With Amyotrophic Lateral Sclerosis (ALS) (NCT02460679)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of possible, probable, laboratory supported probable, or definite ALS by E1
             Escorial Criteria

          -  Forced vital capacity (FVC) ≥ 70% of predicted

          -  Weakness onset within 3 years

          -  Agreement to use contraception if within reproductive years

          -  Willingness and ability to comply with study procedures

          -  Stable regimen of dietary supplements and /or riluzole for at least 30 days prior to
             enrollment

          -  Abstention from use of other investigative or non-approved drugs

          -  Participants must be able to swallow 0.375 * 0.700 inch tablets

        Exclusion Criteria:

          -  Allergy to EPI-589

          -  Use of ventilation

          -  Participation in other intervention studies

          -  Diagnosis of any other neurologic disease

          -  Malignancy within the past 2 years

          -  History of stroke

          -  History of brain surgery

          -  Hepatic insufficiency with liver function tests (LFTs) greater than 3 times upper
             limit of normal (ULN)

          -  Renal insufficiency requiring dialysis

          -  End stage cardiac failure

          -  Participation in a trial of a device, drug, or other therapy for ALS within 3 months
             of screening or during the trial
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? 1
Clinical trial: Hesperidin and Diosmin for Treatment of COVID-19 (NCT04452799)

Eligibility criteria:
Inclusion Criteria:

        Confirmed cases of Covid-19 (all by RT-PCR) Newly diagnosed asymptomatic or with upper
        respiratory tract infection (URTI) patients who will present with rhinitis, pharyngitis, or
        isolated low-grade fever and myalgia, Adult (18-65 Years old) Both sexes

        Exclusion Criteria:

        Patients with bleeding disorders Patients with low to very low blood pressure Patients
        after surgery Immunocompromised patients taking medication upon screening
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: Registry of COVID-19 Patients at AOUI Verona (NCT04497194)

Eligibility criteria:
Inclusion Criteria:

          -  PCR for SARS-CoV 2 positive on NPS swab or high suspicion of SARS-CoV 2 with ongoing
             swab;

          -  All ages;

          -  All genders;

          -  Informed consent obtained.

        Exclusion Criteria:

          -  Failure to obtain the informed consent.
No condition on gender to be admitted to the trial.




Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0