araag2/NLI4PR huggingface dataset:
Clinical trial: Misoprostol for Second Trimester Pregnancy Termination (NCT02669420)

Eligibility criteria:
Inclusion Criteria:

          -  Pregnancy 13-24 weeks.

          -  Women with indication for termination of the pregnancy due to intra uterine fetal
             death

        Exclusion Criteria:-Pregnancy before 13 weeks.

          -  Pregnancy beyond 24 weeks.

          -  Women with scared uterus.

          -  Known hypersensitivity for misoprostol.

          -  Refusal of the woman to participate.
Female
No healthy subjects accepted to join the trial.



Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 1
Clinical trial: Study Evaluating the Efficacy and Safety of Topical Diclofenac Spray in Osteoarthritis of the Knee: Trial II (NCT00546832)

Eligibility criteria:
Inclusion Criteria:

          -  Males or females in generally good health at least 40 years of age

          -  Osteoarthritis (OA) of at least one knee, verified by a weight-bearing radiograph

          -  Subject has taken an oral NSAID or analgesic at least 3 days during the past 30 days
             to treat knee OA pain

        Exclusion Criteria:

          -  Females who are pregnant or lactating or who may become pregnant

          -  Hypersensitivity (exacerbations of asthma, rhinitis, or urticaria) to sulfonamides,
             acetaminophen, diclofenac, celecoxib, aspirin, or any other NSAID

          -  History of myocardial infarction, congestive heart failure, stroke, coronary-artery
             bypass graft surgery, or any other significant cardiovascular disease, or is on any
             form of anticoagulation therapy other than low-dose aspirin (no more than 325 mg/day)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: The Effects of Potassium Citrate on Bone Metabolism (NCT00357331)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women, more than 2 years post menopause

          -  Osteopenia, defined as a T score at the lumbar spine or total hip between -1.0 and
             -2.5

          -  No history of prior fragility fracture

        Exclusion criteria:

          -  Renal insufficiency

          -  Use of potassium sparing diuretics

          -  Use of potassium supplements

          -  Hyperkalemia

          -  Secondary causes of osteoporosis or metabolic bone disease

          -  Delayed gastric emptying

          -  esophageal compression, intestinal obstruction or stricture

          -  use of anticholinergic medication

          -  active urinary tract infection.
Female
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman

Does the patient match the trial criteria? 0
Clinical trial: Autoreactive Anti-Ro/SSA IgE To Determine Primary SjögRen's Syndrome's Disease Activity (NCT03003572)

Eligibility criteria:
Inclusion Criteria:

          -  Primary Sjögren's syndrome according to the American-European Consensus Criteria)

          -  Informed and having signed the study consent form

        Exclusion Criteria:

          -  Secondary Sjögren's syndrome

          -  Other systemic autoimmune disease (e.g. rheumatoid arthritis, AntiNeutrophil
             Antibodies (ANCA) -associated vasculitis, mixed connective tissue disease…)

          -  Incapacity or refusal to sign the informed consent form

          -  Incapacity or refusal to perform the follow-up examinations required by the study

          -  Has received abatacept, sifalimumab, rontalizumab, anifrolumab, belimumab, Tumor
             Necrosis Factor (TNF) antagonists or interferon during the 6 months prior to the
             inclusion

          -  Has any current signs or symptoms of active infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1
Clinical trial: Adaptation Among Adolescents and Adults With Klinefelter Syndrome (NCT00896272)

Eligibility criteria:
-  INCLUSION CRITERIA:

               1. Must have Klinefelter syndrome (47,XXY) by self-report.

               2. Must be 14 years or older.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 14 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient description (patient's own words): I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Does the patient match the trial criteria? 1
Clinical trial: Genetic Analysis and Multimodal Retinal Imaging of Asymptomatic Fovea Plana Cases in the General Population (NCT04658381)

Eligibility criteria:
Inclusion Criteria:

          -  Patient over 18 years old;

          -  Diagnosis of fovea plana in one or both eyes, confirmed by two ophthalmologists
             blinded to each other from OCT-B imaging;

        Exclusion Criteria:

          -  Known Albinism

          -  Known family history of albinism

          -  History of eye surgery other than cataract

          -  Alteration of macular visual function (loss of visual acuity independent of a disorder
             of the environments, central scotoma, metamorphopsies, etc.)

          -  Presence of another anomaly in OCT in addition to the fovea plana (epiretinal
             membrane, damage to the external retina, etc.)

          -  Syndromic fovea plana

          -  Pregnant or breastfeeding woman
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? 0
Clinical trial: Follicle-Stimulating Hormone (FSH) and the Onset of Puberty (NCT00734279)

Eligibility criteria:
Inclusion Criteria:

        Early Puberty Children who have early puberty may participate in this study. Children must
        be between 6 and 10 years of age and be healthy with the exception of having early puberty.
        For early puberty, girls should have had the onset of breast development prior to 8 years
        of age and boys should have the onset of pubic hair growth or genital growth prior to 9
        years of age.

        Inclusion Criteria for Delayed Puberty Children who have late (delayed) puberty may
        participate in this study. Children must be between 12 and 17 years of age and be healthy
        with the exception of having late puberty. In order to have late puberty, boys and girls
        should have short stature compared to their family with at least one year delay in bone age
        as determined by bone age x-ray and/or have the onset of secondary sexual characteristics
        (breast and pubic hair growth) at 12 years of age or later for a girl or 13 years of age or
        later for a boy.

        Exclusion Criteria:

        Early Puberty Children with known genetic disorders, chronic medical conditions requiring
        the use of steroids, and use of medication for puberty within the last 3 months are
        excluded.

        Delayed Puberty Children with known genetic disorders with the exception of possible
        hypogonadotropic hypogonadism, chronic medical conditions requiring the use of steroids,
        and use of medication for puberty within the last 3 months are excluded.

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? 0
Clinical trial: Wearable Sensor to Monitor COVID-19 Like Signs and Symptoms (NCT04393558)

Eligibility criteria:
Inclusion Criteria:

          -  Ages between 18-95 years old

          -  Currently experiencing any COVID-like signs and symptoms such as fever, cough,
             shortness of breath, trouble breathing, persistent pain or pressure in the chest,
             confusion or inability to arouse, bluish lips or face.

          -  Individuals who are not experience any COVID like signs and symptoms (will be asked to
             be healthy control)

          -  Able and willing to give written consent and comply with study procedures.

        Exclusion Criteria:

          -  Inability to understand instructions and follow a three step command.

          -  The subject is pregnant, nursing or planning a pregnancy.

          -  Inability to provide written consent.
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 95 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: Physiology of Weakness in Movement Disorders (NCT00307346)

Eligibility criteria:
-  INCLUSION CRITERIA:

          -  Both patients and healthy volunteers will be between age 18 and 80.

          -  Patients will be evaluated in the Human Motor Control Clinic at NINDS.

          -  The definite diagnosis of the disease may not be completely established at the time of
             recording.

          -  Patients have clear and reproducible symptoms of give way weakness of either upper or
             lower extremities.

          -  Patients have to be able to resist against the examiner for at least two seconds
             before giving way.

          -  Healthy volunteers are right handed adults without history of neurological disease or
             severe head trauma.

        EXCLUSION CRITERIA:

          -  Subjects (patients or volunteers) who cannot understand the instructions and consent
             forms of the protocol will be excluded.

          -  Subjects who cannot follow the instruction during the entire recording for whatever
             reason will be excluded.

          -  Patients with a documented organic central nervous system lesion may be excluded from
             the study. This will be discussed in detail for each individual subject at the Human
             Motor Control Clinic.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 0
Clinical trial: Routine Pathological Examination of Hernia Sac; Is it a Workload or Necessary? (NCT04383249)

Eligibility criteria:
Inclusion Criteria:

          -  Emergency operated patients

          -  Elective operated patients

        Exclusion Criteria:

          -  Hernia repairs without pathology examinations
No condition on gender to be admitted to the trial.




Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1