araag2/NLI4PR huggingface dataset:
Clinical trial: Iodine I-131 Iodocholesterol, Its Use in Adrenal Screening (NCT00037843)

Eligibility criteria:
Adults with suspected adrenal disease, such as adrenal adenoma, carcinoma, hyperplasia, or
        Addison's Disease.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? 1
Clinical trial: Study of Acamprosate in Fragile x Syndrome (NCT01911455)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnostic confirmation of full mutation FXS

          -  Age ≥5 years and <23 years

          -  General good health as determined by physical exam, medical history and laboratory
             work up.

        Exclusion Criteria:

          -  Use of more than two psychotropic medications (medications affecting behavior).

          -  Unstable dosing of any psychotropic medication (medication affecting behavior)

          -  Problems with kidney functioning

          -  Unstable seizure disorder

          -  Change in any anti-convulsant drug dosing in the 60 days prior to study entry

          -  Prior adequate treatment trial with acamprosate as determined by the study doctor

          -  Pregnant or lactating females
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 23 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? 1
Clinical trial: Improved Factor VIII Inhibitor Evaluation (NCT02726139)

Eligibility criteria:
Inclusion Criteria:

          -  hemophilia A

          -  presence of inhibitory antibodies

        Exclusion Criteria:

          -  none
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: CONNECARE-Assuta-Case Study 1 (NCT03327233)

Eligibility criteria:
Inclusion Criteria:

          -  All Maccabi members who arrive at the ER in an unplanned manner

          -  Age over 65

          -  Living in a home and not in a nursing home

          -  LACE> 7

          -  At least three of the following conditions:

               -  Multiple drugs - regular use of four or more drugs

               -  More than one case of hospitalization or visit to the ER in the past year

               -  Malnutrition

               -  Elements of low socio-economic status

          -  The patient and / or the main caregiver speak Hebrew, English or Russian

          -  The patient or primary caregiver has a password to the Maccabi Online website

          -  The patient and / or the primary caregiver have basic technological knowledge in the
             use of the applications

          -  The patient has wireless Internet access at home (via Wifi or through a cellular
             connection)

        Exclusion Criteria:

          -  Patients with cognitive or dementia problems
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? 0
Clinical trial: Memantine for Disability in Amyotrophic Lateral Sclerosis (MEDALS) (NCT00353665)

Eligibility criteria:
Inclusion Criteria:

          -  Definite or probable disease - revise El Escorial criteria

          -  Normal blood tests

          -  Riluzole treatment during 1 month or more

          -  EMG in accordance with El Escorial criteria

        Exclusion Criteria:

          -  Other diseases (such as PNP)

          -  Both ADM muscles < 3 on MRC scale

          -  Conduction block on nerve conduction tests

          -  Disease duration > 3 years

          -  ALS-FRS < 25

          -  Forced vital capacity - <60%
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? 1
Clinical trial: Partial Versus Total Fundoplication in the Surgical Repair of Para-esophageal Hernia. (NCT04436159)

Eligibility criteria:
Inclusion Criteria:

          -  Patients undergoing acute or elective surgery for symptomatic PEH at Ersta Hospital
             and Karolinska University Hospital

        Exclusion Criteria:

          -  age below 18 years

          -  axial sliding hiatal hernia only (type I)

          -  missing informed consent

          -  previous hiatal hernia surgery

          -  American Society of Anesthesiologists (ASA) score IV or above

          -  achalasia

          -  Zollinger-Ellison syndrome

          -  malignant tumor

          -  inability or unwillingness to complete questionnaires
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 0
Clinical trial: The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism (NCT01533129)

Eligibility criteria:
Inclusion Criteria:

          -  Men

          -  Treatment naive

          -  Hypogonadotrophic hypogonadism

        Exclusion Criteria:

          -  Previous history of androgen replacement

          -  Chronic metabolic disorders
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 26 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? 1
Clinical trial: Correlation of Oropharyngeal Pepsin and Gastroesophageal (GE) Reflux (NCT01091805)

Eligibility criteria:
Inclusion Criteria:

          1. Pediatric patients from birth to 18 years (including premature infants) who are deemed
             clinically to require 24 hour esophageal pH/impedance.

          2. Pediatric patients (newborn to 18 years) undergoing MBS who have had or will have
             pH/MII monitoring within 6 months.

          3. Patients' parents or legal guardians will provide written informed consent for the
             protocol. When appropriate, patient assent will be obtained.

        Exclusion Criteria:

          1. Patients with anatomic facial anomalies or facial discomfort precluding nasal
             intubation of the pH/MII catheter.

          2. Patient unable to complete a 24 hour pH/MII study.

          3. Children fed exclusively with nasogastric or nasojejunal (transpyloric) tube at the
             time of study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 0
Clinical trial: Trans-inguinal Pre-peritoneal Hernioplasty Versus Lichtnestein's Technique in Inguinal Hernia Repair (NCT03438786)

Eligibility criteria:
Inclusion Criteria:

          -  . Patients with unilateral non complicated inguinal hernia who will undergo
             hernioplasty in surgery department at AUH

        Exclusion Criteria:

          1. Patients who were unfit for operation.

          2. Patients with bilateral or recurrent inguinal hernia

          3. Patients aged below 18 years,

          4. Patients undergoing emergency hernia repairs
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: The Study of Eustachian Tube Dysfunction and Laryngopharyngeal Reflux (NCT02123498)

Eligibility criteria:
Inclusion Criteria:

          -  They complain of symptoms of ear fullness, ear pain, and/or ear pressure, either
             unilateral or bilateral

          -  They are willing to participate in the study.

          -  They are between the ages of 18 to 80

        Exclusion Criteria:

          -  They have had major ear surgery (not including tympanostomy tubes)

          -  They have a medical condition that is another possible etiology of ear pain or acid
             reflux and may require additional medical or surgical intervention such as: Acute or
             chronic otitis externa, Chronic otitis media, Temporomandibular joint dysfunction,
             Upper aerodigestive track neoplasm, History of head/neck radiation therapy.

          -  They are pregnant. Proton pump inhibitors are a Category C drug with unknown pregnancy
             risks.

          -  They do not wish to participate in the study

          -  They are <18 or >80.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? 1