araag2/NLI4PR huggingface dataset:
Clinical trial: Mindfulness for Osteoarthritis-related Knee Pain (NCT02595099)

Eligibility criteria:
Inclusion Criteria:

          -  Adults over 18 years, there is no upper age limit.

          -  Osteoarthritis of the knee (defined as joint space narrowing and osteophytes in 1 or
             more compartment) and moderate to severe knee pain (defined as 40-80mm on a 100mm
             visual analogue scale).

        Or

          -  Persistent moderate to severe knee pain (40 - 80mm on a 100mm visual analogue scale),
             one year following total knee replacement

        Exclusion Criteria:

          -  People who have previously participated in a 8 week Mindfulness course

          -  Terminal illness and other conditions leading to incapacity to participate in the
             study

          -  Acute knee injury, knee joint surgery or steroid injection to the knee within previous
             3 months or currently on a waiting list for knee joint surgery

          -  Inflammatory arthritis (eg Rheumatoid arthritis or psoriatic arthritis)

          -  Patients who are unable to provide informed consent

          -  Patients who are unable to communicate in English, as the intervention is delivered in
             English
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Effects of Improved Calf Muscle Function on Gait, Balance and Joint Loading in Older Adults (NCT03921801)

Eligibility criteria:
Inclusion Criteria:

          -  age between 65 and 75 (older adults) or 18 and 35 (young adults)

        Exclusion Criteria:

          -  dependent living status

          -  not able walk without assistive device or 30 min without stopping

          -  diagnosed neurological disease or joint disorder and pain during walking

          -  surgery on lower extremities

          -  current musculoskeletal injury

          -  previous cardiovascular event or symptoms during exercise (acute ECG change, coronary
             disease, symptomatic arrhythmia, symptomatic coronary stenosis, heart failure,
             myocarditis, pericarditis, pulmonary embolism, pulmonary infarct, artery bulge or
             rupture risk)

          -  body mass index <18 or >35 kg/m2

          -  contraindications for magnetic resonance imaging

          -  Mini Mental State Examination score of 23 points and lower
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 0
Clinical trial: Study of Recombinant Porcine Factor VIII (FVIII) in Hemophilia and Inhibitors to FVIII (NCT00245245)

Eligibility criteria:
Inclusion Criteria:

        Patients must meet at least the following criteria to participate in the trial:

          -  Age at least 12 years.

          -  Clinical diagnosis of congenital hemophilia A with current inhibitor to human fVIII OR
             the patient is known to have developed an anti-human fVIII inhibitor antibody
             anamnestic response to human fVIII in the past.

          -  OBI-1 inhibitor antibody titer < 20 Bethesda Units at screening.

          -  Uncomplicated joint or soft tissue bleed, or other non-life threatening or non-limb
             threatening bleeding episode.

        Exclusion Criteria:

        Patients will be ineligible to participate if any of the following are present:

          -  Current treatment plan for any acute bleeding episode incorporates the use of human
             fVIII (recombinant or plasma-derived).

          -  Presence of any life- or limb-threatening bleeding episode (defined)

          -  Patient has received any human fVIII or prothrombin complex concentrate (PCC), within
             7 days prior to Screening, OR received any PCC within 7 days prior to treatment with
             OBI-1.

          -  Patient has received recombinant human fVIIa (rVIIa) within 3 days prior to Screening
             OR within 3 days prior to treatment with OBI-1.

          -  Significant liver disease or renal disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Inflammatory Myopathies in Primary Sjögren's Syndrome (NCT03126383)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of Primary Sjögren's syndrome according to the ACR/EULAR classification
             criteria

          -  inflammatory muscle involvement, as diagnosed by the treating physician

        Exclusion Criteria:

          -  Diagnosis of inflammatory myopathy before the diagnosis of pSS
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1
Clinical trial: The Clinical Application of MCCES in Examination of Human Colon (NCT02536144)

Eligibility criteria:
Inclusion Criteria:

          -  Patients who repeatedly have the symptom such as abdominal pain, diarrhea,
             hematochezia and so on, or

          -  Patients who volunteer to the colonoscopy screening.

        Exclusion Criteria:

          -  Dysphagia or swallowing disorder,

          -  Congestive heart failure,

          -  Renal insufficiency,

          -  Prior major abdominal surgery of the gastrointestinal tract,

          -  Known or suspected bowel obstruction,

          -  Presence of a cardiac pacemaker or other implanted electromedical devices,

          -  Allergy or contraindication to the medications used in the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? 0
Clinical trial: Whole Blood Collection From Individuals in the Convalescent Phase of SARS-CoV-2 Infection (NCT04409184)

Eligibility criteria:
Inclusion Criteria:

        Patients who have previously been diagnosed with COVID-19 but are now asymptomatic >14 days
        and a matched number of healthy controls:

          1. Consent: Subject able to provide voluntary written consent before performance of any
             study-related procedure not part of normal medical care, with the understanding that
             consent may be withdrawn by the subject at any time without prejudice to future
             medical care.

          2. SARS-CoV-2 Testing Status:

               1. Experimental Population: Subject has had positive SARS-CoV-2 verified by clinical
                  laboratory OR

               2. Control Population: Subject without testing or negative SARS-CoV-2 testing

          3. Complete resolution and current absence of clinical symptoms Symptoms Defined as:
             Fever, Dry cough, Fatigue, Difficulty breathing, Sore throat, Diarrhea, Rhinorrhea
             (runny nose), or new aches/pains.

          4. Age: Greater or equal to 18 years of age. a. Subject must be able to provide voluntary
             written consent

        Exclusion Criteria:

          1. Ongoing symptoms of COVID19 due to SARS-CoV-2 infection

             a. Symptoms Defined as: Fever, Dry cough, Fatigue, Difficulty breathing, Sore throat,
             Diarrhea, Rhinorrhea (runny nose), or new aches/pains.

          2. Ongoing symptoms not due or not known to be due to SARS-CoV-2 infection

             a. Symptoms Defined as: Fever, Dry cough, Fatigue, Difficulty breathing, Sore throat,
             Diarrhea, Rhinorrhea (runny nose), or new aches/pains.

          3. Patients receiving ongoing medical symptomatic treatment or prophylaxis treatment
             related to COVID-19 due to SARS-CoV-2
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: Testing a Body-functionality Intervention for Body Image in Individuals With Skin Conditions (NCT04445974)

Eligibility criteria:
Inclusion Criteria:

          -  Individuals with dermatological condition (including conditions that affect the skin,
             hair and/or nails). This includes, but is not limited to, acne, eczema, alopecia,
             psoriasis, vitiligo, rosacea, dermatitis, hyperpigmentation, hidradenitis suppurativa
             (HS), hyperhidrosis, hirsutism, neurofibromatosis, onychomycosis, melasma, cysts,
             herpes, ichthyosis, and lichen sclerosus.

          -  Individuals self-reporting that their body image is affected by their skin condition.

          -  Sufficient English to complete the measures and writing exercises

          -  Access to the internet.

        Exclusion Criteria:

          -  As the focus of this research is on skin disease, individuals living with visible
             differences as a consequence of trauma (e.g. scarring from burns or scarring from
             traumatic injury) are not eligible to participate in this study.

          -  Individuals who do not feel their body image is affected by having a dermatological
             condition.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? 1
Clinical trial: Bone Microarchitecture in Women With and Without Fracture (NCT01049191)

Eligibility criteria:
Inclusion Criteria:

          -  Postmenopausal women volunteers age ≥ 50 years

          -  normal BMD or osteopenia (T-score > -2.5 at the L1-4 spine, proximal femur and 1/3rd
             radius) by DXA.

          -  sustained a "fragility" fracture of the spine, hip or wrist, defined as a fracture
             occurring with everyday activities including a fall from standing height or less.

          -  Historical radiographic documentation of fracture will be obtained.

          -  Criteria as defined above without prior fracture, age and bone density matching a
             participant in the fracture group

        Exclusion Criteria:

          -  metabolic bone disease

          -  malignancy

          -  renal failure

          -  use of medications which alter bone turnover

          -  diseases/conditions leading to the non-dominant arm disuse

          -  contraindications to MRI.
Female
Accepts Healthy Volunteers
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? 0
Clinical trial: Effects of Exercise and Rivastigmine on Quality of Life of Alzheimer's Disease Patients (NCT01183806)

Eligibility criteria:
Inclusion Criteria:

          -  Previous diagnosis of probable Alzheimer's disease

          -  At least 55 years of age

          -  Same caregiver (familiar or paid one) for at least 3 months before, who is able to
             follow the patient in a two-day/week exercise program

          -  Do not be taking other prescribed medication for Alzheimer disease

          -  Treated stable hypertension

        Exclusion Criteria:

          -  Mini-Mental State Examination (MMSE) score of less than 12

          -  Can't follow simple commands;

          -  Can't answer two or more items of Quality of life questionnaire

          -  Practiced regular exercise or physiotherapy/ occupational therapy in the last two
             months.

          -  Diagnosed psychiatric condition (including depression).

          -  Use of neuroleptic drugs

          -  Orthopedic, neurologic, or behavioral limitations that may preclude exercise training

          -  Visual or hearing impairment that may preclude exercise training or comprehension
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 55 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 1