araag2/NLI4PR huggingface dataset:
Clinical trial: Risk of Infection of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), COVID-19, in a Massive Musical Show With Transmission Prevention Measures (NCT04668625)

Eligibility criteria:
Inclusion Criteria:

          -  Adults (age 18-59 years) with interest to attend the scheduled musical event who agree
             to participate in the study after signing the informed consent, including explicit
             acceptance of the measures implemented to reduce the risk of transmission of
             SARS-CoV-2.

          -  Negative antigen test performed up to 24 h before the event, in nasopharyngeal swab.

        Exclusion Criteria:

          -  Hypertension

          -  Diabetes Mellitus.

          -  Ischemic heart disease.

          -  Any type of Cancer in active treatment.

          -  Chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and asthma.

          -  Have a positive test for detection of SARS-CoV-2 by the rapid antigen test

          -  Who have a body temperature higher than 37.0º on the same day of the event

          -  Who have a confirmed diagnosis for SARS-CoV-2 in the two weeks prior to the event

          -  Report any symptoms suggestive of a SARS-CoV-2 infection in the 10 days prior to the
             study

          -  Who have been in contact with a person with a confirmed diagnosis of SARS-CoV-2
             infection within two weeks prior to the event.

          -  Living with a person over 70 years of age (inclusive).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 59 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: Placebo Controlled Study of ONO2506PO in the Presence of Riluzole in Patients With Amyotrophic Lateral Sclerosis (ALS) (NCT00403104)

Eligibility criteria:
Inclusion Criteria:

          1. Diagnosis of clinically possible, clinically probable laboratory-supported, clinically
             probable or clinically definite ALS (according to WNF EL Escorial diagnostic criteria,
             revised according to the Airlie House Conference 1998)

          2. Onset of muscle weakness within 14 months randomization

          3. Concomitant standard Riluzole therapy (50mg twice daily)

        Exclusion Criteria:

          1. Presence of a tracheotomy, mechanical ventilation or non-invasive ventilation

          2. Requirement for prescription drugs used for potential neuroprotective benefit -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 74 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? 1
Clinical trial: Strategies for Patients With Osteoarthritis, by Using Assistive Technology and Exercises. (NCT03173989)

Eligibility criteria:
Inclusion Criteria:

          -  Kellgreen and Lawrence (KL) classification for I to III or painful IV osteoarthritis
             (with the use of orthoses for analgesia, in this case).

          -  Capacity to understand and agree to the consent form and questionnaires and
             evaluations.

        Exclusion Criteria:

          -  Patients who had undergone previous non-medical therapeutic treatment for OA of the
             hands;

          -  Who had undergone some surgical procedure in the region or were involved in another
             clinical trial;

          -  Patients with rheumatoid arthritis or other rheumatologic disease, any neurological
             problems.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 1
Clinical trial: Double Push Acoustic Radiation Force (DP ARF) Ultrasound for Monitoring Degeneration in Duchenne Muscular Dystrophy (NCT01506518)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Duchenne muscular dystrophy with clinical onset by age 5

          -  Ability to stand, alone or with assistance, at time of enrollment

          -  Ability to communicate with pertinent staff

          -  Ability to understand and comply with study requirements

          -  Ability to give informed consent.

        Exclusion Criteria:

          -  Confirmed diagnosis of other muscle disease

          -  Previous compartment syndrome

          -  Previous injury to selected limbs

          -  Previous vascular surgery to selected limbs

          -  History of a compressive neuropathy (e.g., sciatic, femoral or tibial palsy in leg)

          -  History of rhabdomyolysis
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 13 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 1
Clinical trial: Measuring hCG Levels in Pregnant Women (NCT02763176)

Eligibility criteria:
Inclusion Criteria:

          -  Intrauterine pregnancy <= 70 days' gestation

          -  Be in general good health

          -  English speaking competency

          -  Be willing and able to sign consent forms

          -  Agree to comply with the study procedures, including returning for three study visits
             that each involve a blood draw and urine pregnancy test for measuring hCG

        Exclusion Criteria:

          -  Women less than 18 years of age.

          -  Any women not meeting the inclusion criteria listed above will be excluded from
             participating in the trial.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Application of Diffusion Tensor Imaging in Alzheimer's Disease :Quantification of White Matter Micro-structural Changes (NCT03255720)

Eligibility criteria:
Inclusion Criteria:

          1. cognitive complaints with interference in complex occupational and social activities.

          2. changes in cognition reported by the patient ,informant or clinician.

          3. absence of profound sub-cortical ischemic changes.

        Exclusion Criteria:

          1. state of delirium

          2. stroke event within 2 weeks

          3. appearance of cortical and /cortico-subcortical non -lacunar territorial infarcts and
             watershed infarcts ,hemorrhage ,signs of normal pressure hydrocephalus ,and specific
             causes of white matter lesions (e.g. multiple sclerosis, sarcoidosis, brain
             irradiation)

          4. derangements in serology tests contributing to cognitive impairment (e.g. abnormal
             levels of free T4 or rapid plasma reagin.

          5. severe hearing or visual impairment.

          6. cases of severe dementia.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 1
Clinical trial: Genetic Component of Handedness (NCT00005003)

Eligibility criteria:
INCLUSION CRITERIA:

        Members of families meeting the following criteria are eligible to participate:

        Have two left-handed siblings.

        Have at least one right-handed parent with no other known left-handed first degree
        relatives.

        EXCLUSION CRITERIA:

        All members of a family may be excluded if the right-handed parents or the left-handed
        siblings will not participate.

        Individuals in families whose left-handed siblings are under the age of eight are not
        eligible to participate.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? 1
Clinical trial: A Study to Evaluate Efficacy of rFVIIIFc for Immune Tolerance Induction (ITI) in Severe Hemophilia A Participants With Inhibitors Undergoing the First ITI Treatment (verITI-8 Study) (NCT03093480)

Eligibility criteria:
Inclusion Criteria:

          -  Ability of the participant or his legally authorized representative (e.g., parent or
             legal guardian) to understand the purpose and risks of the study and provide signed
             and dated informed consent and authorization to use protected health information in
             accordance with national and local participant privacy regulations

          -  Male participants of any age diagnosed with severe hemophilia A (as confirmed from the
             medical record)

          -  Currently diagnosed with high titer inhibitors (historical peak greater than or equal
             to (>=) 5 Bethesda units per milliliter (BU/mL), according to medical records)

          -  Previously treated with any plasma-derived or recombinant conventional or Extended
             Half-Life FVIII

        Exclusion Criteria:

          -  Other coagulation disorder(s) in addition to hemophilia A

          -  Previous immune tolerance induction (ITI)

          -  History of hypersensitivity or anaphylaxis associated with any factor VIII (FVIII)
             administration

          -  Planned major surgery scheduled during the study unless deferred until after study
             completion (minor surgery such as tooth extraction or insertion/replacement of central
             venous access device is allowed)

          -  Abnormal renal function (serum creatinine >1.5 milligram per deciliter (mg/dL) or 2 ×
             upper limit of normal (ULN) for participant age based on local laboratory range) as
             assessed by local laboratory

          -  Serum alanine aminotransferase or aspartate aminotransferase > 5 × upper limit of
             normal (ULN) as assessed by local laboratory
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading (NCT01090375)

Eligibility criteria:
Inclusion Criteria:

          -  verified osteoarthritis (x-ray)of the knee, female,

        Exclusion Criteria:

          -  dementia, inflammatory diseases, regular pain medication
Female

Subject must be at least 55 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 0
Clinical trial: MAgnetic Gastrointestinal Universal Septotome: a Safety and Feasibility Study (MAGUS) (NCT04480216)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18 years or older.

          -  Patient has got evaluable symptoms (dysphagia, regurgitation, pain, weight loss,
             halitosis or others) associated with one of the following pathology:

               1. Diverticulum of the esophagus;

               2. A pseudo-diverticulum of the upper GI tract;

               3. Candy cane syndrome;

          -  Willing and able to comply with the study procedures and provide written informed
             consent to participate in the study.

        Exclusion Criteria:

          -  Refractory stenosis of the UGI proximal to the septum;

          -  Septum height smaller than 2,5 cm or higher than 6 cm (check through CT scan, Barium
             Swallow or other imaging method);

          -  Coagulation disorders;

          -  Previous implantation of a magnetic-sensitive medical device (including active
             electronic implant, metallic stent, …);

          -  Dysphagia related to motility disorder;

          -  Planned MRI in the following month (30 days) of intervention.

          -  Concurrent medical condition that would affect the investigator's ability to evaluate
             the patient's condition or could compromise patient safety;

          -  Patient went through a surgery less than 8 weeks before implantation of the magnets;

          -  Currently enrolled in another clinical trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? 1