araag2/NLI4PR huggingface dataset:
Clinical trial: Trial of Hydroxychloroquine In Covid-19 Kinetics (NCT04353271)

Eligibility criteria:
Inclusion Criteria:

          -  Symptoms occurring within 3 days prior to patient presenting to USA Facility for PCR
             nasopharyngeal swab

          -  Nasopharyngeal swab positive for Covid-19 infection and/or exposure and/or symptoms
             congruent with fever and cough

          -  Male or Female age 19 to 89 years

          -  Able to take oral medications

          -  Patients not requiring hospitalization

          -  Provision of informed consent

        Exclusion Criteria:

          -  Known history of EKG QTc prolongation abnormality

          -  Contraindication or allergy to hydroxychloroquine

          -  Retinal eye disease

          -  Known glucose-6 phosphate dehydrogenase (G-6-PD) deficiency

          -  Known chronic kidney disease, stage 4 or 5 or receiving dialysis

          -  Weight < 40 kg

          -  Current use of: hydroxychloroquine or cardiac medicines of: flecainide, Tambocor;
             amiodarone, Cordarone, Pacerone; digoxin or Digox, Digitek, Lanoxin; procainamide or
             Procan, Procanbid, propafenone, Rythmal)

          -  Known hepatic disease (cirrhosis, hepatitis)

          -  Active treatment for cancer (chemotherapy, radiation, surgery within 3 months

          -  On immunosuppressive drugs steroids, antirejection medications.

          -  Recipient of solid organ transplant

          -  Pregnancy/breastfeeding

          -  Past medical history Porphyria (may exacerbate disease)

          -  PMH Psoariasis (can worsen disease)

          -  No access to internet or email

          -  Current suicidal thoughts according to Columbia scale

          -  In the screening process before signing consent, subjects will be asked if they are
             suicidal. If this response is yes, patients will be excluded from trial and directed
             to the National Suicide Prevention Lifeline: 1-800-273-8255.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.
Subject must be at most 85 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: Genotropin Treatment In Very Young Children Born Small For Gestational Age (NCT00627523)

Eligibility criteria:
Inclusion Criteria:

        Caucasian male or female subjects aged between 19-29 months at Screening Visit 1.

        Born SGA (birth length and/or weight <-2 SD for gestational age, using country-specific
        standards).

        Height below -2.5 SD at screening (19-29 months of age). At least one measurement of length
        between 12 and 18 months of age. Normal karyotype in girls to exclude Turners syndrome.

        Exclusion Criteria:

        Severe Intra-Uterine Growth Retardation (IUGR) (birth length below - 4 SD for gestational
        age), if associated with dysmorphic features.

        Severe prematurity (Gestational Age (GA) <32 weeks of gestation). Ongoing catch-up growth
        (defined as growth velocity SDS at inclusion >0) based on at least 4 months measurement
        interval).

        Severe familial short stature defined as: Father's height below 155 cm or mother's height
        below 145 cm.

        Defined neurological defects and/or severe neurodevelopmental delay.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Months old.
Subject must be at most 29 Months

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 0
Clinical trial: Nuclear Magnetic Resonance Therapy in Knee Osteoarthrosis (NCT01603017)

Eligibility criteria:
Inclusion Criteria:

          -  Osteoarthrosis of the knee(s)

          -  Moderately severe (grade 1-2)

        Exclusion Criteria:

          -  Prior knee surgery

          -  Implanted metallic devices
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Angiotensin Converting Enzyme Inhibitors in Marfan Syndrome (NCT00485368)

Eligibility criteria:
Inclusion Criteria:

          -  Age 18-40

          -  Diagnosis of Marfan Syndrome, on the basis of the Ghent Criteria

        Exclusion Criteria:

          -  Age <18, >40

          -  Women of child-bearing potential not on adequate contraception

          -  Serum creatinine of >0.11

          -  A history of intolerance to ACEI

          -  Patients on angiotensin receptor blockers

          -  Blood pressure >140/90mmHg

          -  History of previous aortic surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? 1
Clinical trial: Changes of Bone Turnover Markers and Bone Mineral Density After Osteoporosis Treatment (NCT02156999)

Eligibility criteria:
Inclusion Criteria:

          -  Osteoporosis

        Exclusion Criteria:

          -  Kidney, parathyroid, congenital bone metabolic disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 100 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman

Does the patient match the trial criteria? 1
Clinical trial: Assessing the Efficacy of Clomiphene Citrate in Patients With Azoospermia and Hypoandrogenism (NCT02137265)

Eligibility criteria:
Inclusion Criteria:

          -  Patients over 18 years old.

          -  Man seeking fertility treatment.

          -  Azoospermia confirmed in at least 2 semen analyses with centrifugation.

          -  Testosterone <300 ng/dL and Bioavailable Testosterone<156 ng/dL.

        Exclusion Criteria:

          -  Presence of genetic disorders: Y chromosome deletions or abnormal karyotypes.

          -  Luteinizing hormone (LH) >25 IU/mL.

          -  Estradiol > 40 ng/dL.

          -  Hypogonadotropic hypogonadism (LH <2 IU/mL and Follicle Stimulating Hormone (FSH) <1
             IU/mL).

          -  Obstructive azoospermia (FSH <7.6 IU/mL plus testicle longitudinally axis >4.6 cm or
             bilateral absence of vas deferens or surgical history of vasectomy).

          -  Clinical varicocele (palpable or visible in physical exam)

          -  Previous history of cryptorchidism.

          -  Use of chemotherapy, testosterone, or anti-androgen in the last two years. Partner >40
             years or female factor infertility associated.

          -  Contraindications to clomiphene use: depression, heart and liver impairment,
             uncontrolled thyroid/adrenal dysfunction, organic intracranial lesions.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? 0
Clinical trial: Imaging of Arthropathy in Boys With Hemophilia in China (NCT03914716)

Eligibility criteria:
Inclusion Criteria:

          -  Hemophilia A with baseline FVIII levels of <2%

          -  Clinical history of ≥ 50 exposure days to FVIII prior to the study start.

          -  On-demand treatment, prophylaxis FVIII infusions or treatment with plasma-derived
             products for >3 months prior to enrollment into the study.

        Exclusion Criteria:

          -  History of FVIII inhibitor (titer >0.6 Bethesda Units [BU])

          -  Chronic renal failure (serum creatinine >2.0 mg /dL).

          -  Chronic liver disease (alanine aminotransferase [ALT] >200 U/L).

          -  Clinically documented immunodeficiency.

          -  Anticipation of need for major surgery during the study period.

          -  Association of diseases known to mimic or cause joint diseases such as symptomatic
             human immunodeficiency virus (HIV) infection, juvenile idiopathic arthritis, and
             metabolic bone diseases.

          -  Social barriers for participation in the study such as long distance between home and
             the comprehensive care centre, and documented track record of non-compliance to
             therapies or participation in clinical studies.

          -  Neuro-developmental/behavioral problems.

          -  Contraindications to MR imaging (presence of heart pacemakers, metallic foreign bodies
             in the eye, aneurysm clips, severe claustrophobia).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 4 Years old.
Subject must be at most 11 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion (NCT00313066)

Eligibility criteria:
Inclusion Criteria:

        - patients with pleural effusion

        Exclusion Criteria:

          -  HIV infection
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? 1
Clinical trial: A Web-based Digital Distance Visual Acuity Test (NCT04756596)

Eligibility criteria:
Inclusion Criteria:

          -  Patients of our outpatient ophthalmology clinic

          -  Age between 18 to 75 years

        Exclusion Criteria:

          -  Dyslexia

          -  Attention-deficiency

          -  Former diagnosis of mental and/or psychiatric diseases

          -  Inability to cooperate
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 67-year-old man comes to the clinic with slowly worsening vision in both eyes.  He is not able to drive at night, as the symptoms are worse at night. His pupils are normal in diameter both in the light and darkness. Other medical history is unremarkable.  Ocular examination shows loss of the red reflex and blurry vision.  Acuity testing shows 50/100 vision in both eyes with normal visual field testing. His blood pressure is 130/70 and pulse is 68/min. the other physical examinations are normal.

Patient description (patient's own words): I am a 67 years-old man, and I haven't been able to drive at night due to my vision getting worse. My vision is not the best in general, but night makes it even worse. The ophthalmologist told me that my pupils were normal. However, I have slow reflexes and blurry vision. My acuity test came back with 50/100 vision in both of my eyes. They also took my blood pressure, which was 130/70 with a 68 pulse. My other exams came back just fine.

Does the patient match the trial criteria? 1
Clinical trial: Ultra Structure Of Peritoneum At Electronic Microscopy In Control Subjects And Patients With Gastric Cancer (NCT00935779)

Eligibility criteria:
Inclusion Criteria:

          -  patients with operable local gastric adenocarcinoma

        Exclusion Criteria:

          -  previous abdominal surgery

          -  previous open or blunt abdominal trauma

          -  history of inflammatory bowel disease or Typhoid Fever, Gallstone disease,
             chemotherapy or radiotherapy, or any other abdominal condition that could alter
             peritoneal integrity.

          -  All other gastric malignancies such as lymphomas, GIST, carcinoids
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? 1
Clinical trial: Urea and Creatinine Level in Vaginal Fluid as a Predicator for Length of Latency Period in Prelabour Membranes Rupture (NCT03213535)

Eligibility criteria:
Inclusion Criteria:

          1. Maternal age between 20-35 years.

          2. 32-35 weeks gestational age.

          3. Viable fetus.

        Exclusion Criteria:

          1. Vaginal bleeding either spontaneous or traumatic e.g. placenta previa.

          2. Chorioamnionitis.

          3. Multiple pregnancy.

          4. Presence of uterine contractions.

          5. Amniotic fluid disorders e.g. polyhydramnios

          6. Meconium stained amniotic fluid prior to active phase of labor.

          7. Maternal disease necessitating termination of pregnancy e.g. severe preeclampsia
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0