araag2/NLI4PR huggingface dataset:
Clinical trial: Study of Chediak-Higashi Syndrome (NCT00005917)

Eligibility criteria:
-  ELIGIBILITY:

        Patients will be between the age of 1 month and 70 years. All patients entering this study
        will have some degree of oculocutaneous albinism plus either a bleeding diathesis or a
        history of excessive infections in childhood. Objective evidence of a platelet storage pool
        deficiency (e.g., an abnormal secondary aggregation response or absent platelet dense
        bodies) or of a lysosomal fusion abnormality (e.g., giant cytoplasmic granules in
        leucocytes) will not be required.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Month old.
Subject must be at most 70 Years

Patient description (medical language): A 4-year-old boy comes to the office for the follow up of his confirmed oculocutaneous albinism.  The patient was born at 38 weeks gestation with no complications.  Vital signs are normal.  Weight and height are at the 50th percentile.  On examination, iris transillumination is present, and there are no apparent foveae on funduscopic examination.  Optic nerves are small and gray.  All the hairs including eyebrows and lashes are white.

Patient description (patient's own words): I brought my four-year-old son to his follow-up consultation for his albinism. All his hair is white, even lashes and eyebrows. My baby was born at 38 weeks pregnant with no complications whatsoever. During the consultations his vitals were normal and now his weight and height are at the 50th percentile. The doctor did an eye exam and it seems that his iris has a kind of transillumination, and there are no foveae. The doctor told me that his optic nerves are small and gray.

Does the patient match the trial criteria? 1
Clinical trial: Role of Vagal Tone in Rumination Syndrome (NCT03912636)

Eligibility criteria:
Inclusion Criteria:

          1. Healthy volunteers (HVs)

               -  18-65 years old

               -  No history of any gastrointestinal (GI) symptoms in the 3 months prior to the
                  study.

               -  No medications 3 months prior to the study

          2. Rumination patients

               -  18-65 years old

               -  Fulfilling ROME IV clinical criteria for rumination

               -  Confirmed rumination syndrome by High Resolution Impedance Monometry within 12
                  months prior to the study

               -  No history of performing DiaB as a therapy for rumination syndrome.

               -  No medications which may affect vagal tone, the number of rumination episodes and
                  GI motility 3 months prior to the study. (i.e. opioids, Baclofen ,
                  anticholinergics drugs, prokinetics, beta-blockers)

        Exclusion Criteria:

          -  Pregnant or lactating women

          -  History of GI surgeries apart from appendectomy

          -  Alcohol or substance abuse, mental health illness

          -  Inability to obtain informed consent

          -  Non-fluent English speakers

          -  Participants with food intolerances or allergies that would not be able to take in the
             test meal (McDonalds Big Mac meal)

          -  Major comorbidities such as significant cardiac/pulmonary disease, cancer,
             life-threatening conditions or other life-limiting conditions

          -  Evidence of relevant organic diseases. (in endoscopy, CT.)

          -  Evidence of major esophageal motility disorders (Chicago classification ver3.0) (21)

          -  Known allergy to ECG electrodes or latex

          -  History of diabetes
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? 0
Clinical trial: SSRI Study for Functional Dyspepsia (SS) (NCT02153567)

Eligibility criteria:
Inclusion Criteria:

          -  • Patients with functional dyspepsia that fulfill Rome III criteria

               -  Has element of anxiety or depression reported at baseline screened by HADS
                  (either subscale of HADS - HAS or HDS scores 8 or higher)

               -  Age 18-60

               -  Provision of written consent

               -  No evidence of structural disease (including at upper endoscopy) that is likely
                  to explain the dyspeptic symptoms

        Exclusion Criteria:

          -  • Diabetes mellitus

               -  Organic brain syndrome

               -  Moderate or severe Depression diagnosed by Structured Clinical Interview for
                  DSM-IV conducted by a psychiatrist or trained research staff

               -  History of psychosis, bipolar disorder or substance abuse/dependence

               -  On psychiatric medication (SSRI, SNRI, tricyclic antidepressants, anxiolytics)

               -  Has suicidal ideation in the past two weeks as screened by PHQ at baseline
                  assessment

               -  Diagnosis of GERD by GERDQ questionnaire (GERDQ score ≥8) included in the FGI
                  Screening Questionnaire (v.3) completed at baseline visit

               -  Concurrent medications that affect GI motility

               -  History of gastric surgery

               -  Organic disease as cause of dyspepsia

               -  H. pylori infection

               -  Use of PPI or NSAID in the past 4 weeks

               -  Pregnancy

               -  Known hypersensitivity to SSRI

               -  Unable to read Chinese or illiterate
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? 0
Clinical trial: Study and Treatment of Inflammatory Muscle Diseases (NCT00001265)

Eligibility criteria:
-  INCLUSION CRITERIA:

        All eligible patients are invited to participate in this protocol. Patients are adults and
        minors, aged 16 or higher, with possible idiopathic muscle disease (suspected or
        confirmed). Since both men and women are affected with the disease, both sexes will be
        studied. All ethnic and racial groups are at risk and will be included. Healthy volunteers
        will be eligible only if they are adults aged 18 or older and only if they are willing to
        provide informed consent.

        EXCLUSION:

          -  Children (age less than 16 years) are excluded

          -  Subjects with severe active infection (such as requiring intravenous antibiotics) or
             other co-morbidities that in the opinion of the investigator would warrant exclusion.

          -  Subjects or their legal guardians who are unable or unwilling to give informed
             consent/assent.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient description (patient's own words): I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Does the patient match the trial criteria? 1
Clinical trial: Erythema Migrans in Elderly (NCT03371563)

Eligibility criteria:
Inclusion Criteria:

          -  erythema migrans

        Exclusion Criteria:

          -  pregnancy or lactation

          -  immunocompromised

          -  taking antibiotic with antiborrelial activity within 10 days

          -  received <10 days of antibiotic therapy for erythema migrans

          -  had an intercurrent episode of Lyme borreliosis during follow-up
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? 1
Clinical trial: The Ketogenic Diet for Alzheimer's Disease (NCT04701957)

Eligibility criteria:
Inclusion Criteria:

          -  Age >= 50

          -  AD confirmed by CSF biomarkers

          -  CDR score=0.5

          -  Speaking/understanding French

          -  Presence of a caregiver

        Exclusion Criteria:

          -  Diabetes

          -  Other neurological disease

          -  Chronic inflammatory disease or anti-inflammatory medication (e.g. NSAI,
             corticosteroids)

          -  Uncontrolled dyslipidemia

          -  Malnutrition (BMI < 18; or weight loss > 5% in 1 month or 10% in 6 months; or MNA <
             17)

          -  Severe chronic condition or organ dysfunction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 0
Clinical trial: Lyme Borreliosis and Early Cutaneous Diagnostic (NCT02414789)

Eligibility criteria:
Inclusion Criteria:

          -  Erythema migrant as criteria EUCALB or atypical form associated to tick's sting

          -  Patient having signed a consent

          -  Patient affiliated to a social security scheme

        Exclusion Criteria:

          -  Prior treatment with antibiotics

          -  Erythema migrans on the face

          -  Bleeding disorders

          -  Anticoagulant treatment

          -  Inability to give clear information (subject in an emergency situation, understanding
             of the topic difficulty, ...)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 31-year-old woman comes to the office due to 3 days of rash on her left arm.  The lesion is mildly pruritic but not painful.  She is otherwise healthy and occasionally takes ibuprofen during the first few days of her menstrual period.  Temperature is 37 C, blood pressure is 110/75 mm Hg, and pulse is 95/min. The lesion is like a target sign known as erythema migrans. She recently went for an adventure trip in New Hampshire. The patient is diagnosed with Lyme disease.

Patient description (patient's own words): I went to the clinic because I had a rash on my left arm for three days, and the lesion started to be putrid, but it was not painful. I'm a 31-year-old healthy woman and the only medication I use is ibuprofen when I get my periods. They took my temperature, which turned out to be 37°C and took my blood pressure which was 110/75 and my pulse 95. My lesion is round like a target sign. I just came back from a New Hampshire road trip with my friends. Unfortunately, the doctor diagnosed me with Lyme disease.

Does the patient match the trial criteria? 1
Clinical trial: Efficiency and Safety of Pleural Biopsy Methods in the Diagnosis of Pleural Diseases (NCT03153501)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with pleural diseases

        Exclusion Criteria:

          -  Patients with other lung diseases
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? 1
Clinical trial: Accuracy of Whole-Blood Testing for Rapid Detection of Pregnancy (NCT00373139)

Eligibility criteria:
Inclusion Criteria:

          1. Healthy adult women of child bearing age.

          2. Who either request a pregnancy test, or require a pregnancy test for diagnostic
             studies or treatment.

        Exclusion Criteria:

          1. Minors

          2. Adults who are unable to independently give consent for study

          3. Known pregnancy (i.e. - patient appears obviously pregnant)

          4. Hemodynamically unstable.

          5. Moderately to severely ill-appearing or in moderate to severe pain.

          6. Technically not possible to obtain blood from the study subject.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Platelet Rich Plasma Injection for Knee Pain (NCT01747018)

Eligibility criteria:
Inclusion Criteria:

          -  Patients between 18 and 65 years of age with early osteoarthritis and degenerative
             chondropathy who had previously taken medication for more than six months and without
             physical improvement

        Exclusion Criteria:

          -  advanced osteoarthritis (Kellgren-Lawrence Grading Scale > 2) and inflammatory
             arthritis with severe deformity exceeding the above range.

          -  patellofemoral instability,

          -  a history of drug abuse, and/or

          -  psychological problems
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1