araag2/NLI4PR huggingface dataset:
Clinical trial: Tranexamic Acid (TA) vs Combined Oral Contraceptive (COCP) Pilot Study (NCT01428713)

Eligibility criteria:
Inclusion Criteria:

          1. Menstruating females with menorrhagia or menometrorrhagia referred to hematology or
             gynecology clinics at Texas Childrens Hospital. Menorrhagia is defined as regular
             periods with heavy menstrual bleeding with a PBAC score greater than 100;
             menometrorrhagia is heavy vaginal bleeding occurring at irregular intervals.

          2. PBAC Score greater than 100 for 2 consecutive cycles

          3. Pelvic ultrasound that excludes pelvic pathology that can cause menorrhagia within 12
             months prior to study participation.

          4. Normal external genitalia examination within 6 months prior to study participation.

          5. Normal thyroid stimulating hormone (TSH) in the last 6 months prior to study
             participation.

          6. Negative urine or serum pregnancy test within 4 weeks prior to study participation.

        Exclusion Criteria:

          1. Presence of intra uterine device.

          2. Presence of a diagnosed bleeding disorder based on the standard work-up including
             complete blood count (CBC), prothrombin time, partial thromboplastin time, fibrinogen,
             von Willebrand panel and platelet function analysis (PFA-100) or platelet aggregation.

          3. Intake of medications with increased risk of bleeding

          4. Taking herbal products.

          5. Sexually active status.

          6. Body weight less than 40 kg.
Female
No healthy subjects accepted to join the trial.

Subject must be at most 21 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 0
Clinical trial: Integrating Behavioral Health and Primary Care for Comorbid Behavioral and Medical Problems (NCT02868983)

Eligibility criteria:
Inclusion Criteria:

          -  Over 18 years of age

          -  At least one target chronic medical condition:

          -  arthritis

          -  asthma

          -  chronic obstructive lung disease

          -  diabetes

          -  heart failure

          -  or hypertension.

          -  Evidence of a behavioral problem or need:

          -  Diagnosis of:

          -  anxiety

          -  chronic pain including headache

          -  depression

          -  fibromyalgia

          -  insomnia

          -  irritable bowel syndrome

          -  problem drinking

          -  substance use disorder

          -  OR persistent use of certain medications used for behavioral concerns:

          -  antidepressants

          -  anxiolytics

          -  opioids

          -  antineuropathy agents

          -  OR persistent failure to attain physiologic control of a medical problem:

          -  blood pressure>165 while on 3 or more medications

          -  A1C > 9% for 6 months)

          -  OR the presence of three or more of the target chronic medical conditions.

        Exclusion Criteria:

          -  Not seeking care at a participating practice

          -  Inability to consent due to cognitive and/or developmental impairment/delays

          -  Living in the same household as a previously enrolled study participant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? 1
Clinical trial: Follow Fever to Decide (NCT04311268)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy male or female,

          -  Between 18 and 40 years of age for the WP I and II phases, and between 18 and 80 years
             of age for the WP III phase,

          -  Having an BMI within the range [18.5; 24.9] kg/m² for the Work Package I and II
             phases, and between [18.5; 34.9] kg/m² for the Work Package III phase,

          -  Beneficiary of the social security,

          -  Provided informed consent for participation in the study.

        Exclusion Criteria:

          -  Presenting an acute pathology,

          -  Chronic pathology not followed and balanced,

          -  Having intestinal disorders (diverticles, disorders of the motility of the digestive
             tract, ...) or having undergone surgery at the gastrointestinal level,

          -  With known swallowing disorders,

          -  Having an alcohol dependence (more than 28 alcohol units per week), benzodiazepines or
             any illicit product,

          -  Smoking more than 5 cigarettes per day,

          -  Working nights or shift work,

          -  Simultaneous participation in other clinical research or participation in another
             clinical study for which the exclusion period has not ended.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: Memantine Treatment in Fragile X-Associated Tremor/Ataxia Syndrome (NCT00584948)

Eligibility criteria:
Inclusion Criteria:

          -  Fragile X premutation carrier (CGG repeat 55-200)with neurological symptoms; Clinical
             FXTAS Stage 1-5

        Exclusion Criteria:

          -  Previous reaction to memantine
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 30 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? 0
Clinical trial: Head and Neck cancERs International cOviD-19 collabOraTion (NCT04632173)

Eligibility criteria:
Inclusion Criteria:

        Any head and neck cancer patients (including salivary gland, thyroid, nasal and paranasal
        cancer with a COVID-19 diagnosis defined as any of the following:

          -  Laboratory confirmed [Real Time - Polymerase Chain Reaction (RT-PCR) technique]
             COVID-19.

          -  Suspected COVID-19 cases; diagnosed clinically based on symptoms (fever >37.5°,
             decrease of oximeter saturation of at least 5 %, cough, diarrhoea, otitis, dysgeusia,
             anosmia, myalgia, arthralgia, conjunctivitis and rhinorrhea and exposure to confirmed
             COVID-19 positive case (laboratory confirmation).

          -  Clinically diagnosed cases; suspected cases with lung imaging features consistent with
             coronavirus pneumonia.

          -  Asymptomatic cases; diagnosed based on positive viral nucleic acid test results but
             without any COVID- 19 symptoms

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: Effects of Hormone Replacement Therapy on Arthralgia in Postmenopausal Women (NCT02838576)

Eligibility criteria:
Inclusion Criteria:

          -  age between 45 and 55 years

          -  chronic arthralgia related to climacteric

          -  regular mammography and pap smear test in the last twelve months

          -  availability to attend hormone replacement therapy

          -  maximum of ten years of amenorrhea according to the criteria of Stages of Reproductive
             Aging Workshop (STRAW)

          -  without use of hormone replacement therapy, at least, previous six months

          -  no contraindication to hormone replacement therapy (current or past of breast and / or
             cervical cancer, severe current or recent heart disease, thromboembolism, hypertension
             with no control, metabolic diseases (but stable thyroid disease) and endometrial
             hyperplasia to be enlightened

          -  Informed consent

        Exclusion Criteria:

          -  autoimmune diseases

          -  visceral pain (chronic pelvic pain, dyspareunia, irritable bowel syndrome)

          -  systemic diseases (rheumatic, neurological, oncology, sexually transmitted infection)

          -  body mass index of 30 or greater

          -  soy diet

          -  abuse of alcohol and drugs

          -  large surgeries
Female
Accepts Healthy Volunteers
Subject must be at least 45 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 0
Clinical trial: PREventative Study Against URate-lowering Drug-induced Gout Exacerbations 1 (NCT00829829)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female 18 to 80 years of age;

          -  Previously met the preliminary criteria of the American Rheumatism Association (ARA)
             for the classification; of the acute arthritis of primary gout;

          -  At least 2 gout flares in the year prior to the screening visit;

          -  Serum uric acid greater than or equal to 7.5 mg/dL at the screening visit;

        Exclusion Criteria:

          -  Acute gout flare within 2 weeks of the screening visit or during screening;

          -  Persistent chronic or active infections;

          -  History of an allergic reaction to allopurinol;

          -  History or presence of cancer within 5 years of the screening visit;

          -  Previous exposure to Rilonacept;

          -  Use of allopurinol, benzbromarone, febuxostat, probenecid or sulfinpyrazone within 3
             months prior to the screening visit.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 0
Clinical trial: Comparing Efficacy of Microwave vs Embolization Treatment for Adenomyosis (NCT04209127)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women aged 30-55 with symptomatic adenomyosis

          -  Premenopausal

          -  Adenomyosis diagnosted by TVUS and MRI

          -  Willing to comply with protocol

        Exclusion Criteria:

          -  Current or future childwish

          -  Body Mass Index >35

          -  Treatment with anticoagulant/bleeding disorder

          -  Visible myomas >3cm or visible endometriosis on UL/MRI

          -  Contraindication for UAE or general anesthesia
Female
No healthy subjects accepted to join the trial.
Subject must be at least 30 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 0
Clinical trial: Using Simulation-Based Training to Incorporate Lung Ultrasound Into Physical Examination (NCT02152072)

Eligibility criteria:
Inclusion Criteria:

          -  Third year medical students who signed the consent

        Exclusion Criteria:

          -  a medical student who is not a third year and/or didn't signed the consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 30-year-old man who is a computer scientist came to the clinic with the lab result stating azoospermia.  The patient is sexually active with his wife and does not use any contraception methods.  They have been trying to conceive for the past year with no success.  The patient has a past medical history of recurrent pneumonia, shortness of breath, and  persistent cough that produces large amounts of thick sputum. The patient had multiple lung infections during childhood. He does not smoke, use illicit drugs or alcohol.  The patient has no history of other medical conditions including allergies or any kind of surgery.  On physical examination, the digits show clubbing.  An ultrasound shows bilateral absence of the vas deferens, and FEV1 was 75% on the respiratory function test.

Patient description (patient's own words): I'm a 30-year-old computer scientist. I did some lab tests that came back quite alarming, stating that I have azoospermia?! I'm sexually active with my wife and we don't use contraception. We've been trying to have a child for the past year. I have a medical history of pneumonia and shortness of breath and regular wet cough. I had several lung infections when I was a kid. That's why I'm very careful and don't smoke, do drugs, or drink. I don't have other medical conditions including allergies or any kind of surgery. The doctor did the clubbing test on my fingers, which was positive. I also did an ultrasound and it showed that I'm missing the tubes that carry sperm around. I also had a 75% for my respiratory function test.

Does the patient match the trial criteria? 1