araag2/NLI4PR huggingface dataset:
Clinical trial: A Study to Assess Changes in Clinical Management After DaTSCAN Imaging of Subjects With Clinically Uncertain Parkinsonism or an Illness With Similar Symptoms (NCT00382967)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects with clinically uncertain Parkinsonian Syndromes or monosymptomatic, atypical
             or incomplete presentation of tremor, rigidity, bradykinesia or postural instability.

          -  Onset of clinical manifestations within the last 5 years

        Exclusion Criteria:

          -  Differential diagnosis between Parkinsons´s Disease and Progressive Supranuclear Palsy
             or between Parkinson´s Disease and Multiple System Atrophy

          -  Subjects with an established/certain movement disorder clinical diagnosis

          -  Presence of known causes of tremor
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 1
Clinical trial: the Effect of Mixture of Natural Products As Salivary Substitutes in Treatment Of Xerostomia (NCT04252209)

Eligibility criteria:
Inclusion Criteria:

          1. Adult patients

          2. Patients physically able to participate in the clinical trial.

          3. Patients diagnosed with Sjogren's syndrome using 2016 ACR/EULAR classification
             criteria (Shiboski et al., 2017).

          4. Secondary sjogren patients with rheumatoid arthritis.

          5. Patients with clinical oral dryness positive scores.

        Exclusion Criteria:

          1. Patients with previous radiotherapy.

          2. Patients not approved to participate in the clinical trial.

          3. Patients didn't complain from xerostomia.

          4. Patients with diabetes mellitus.

          5. Patients taking drugs caused xerostomia as antidepressants, anticholinergics,
             antihistamines, and anxiolytics and antihypertensives (Campos et al., 2019).

          6. Patients with symptomatic oral lesions
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1
Clinical trial: Testosterone in Bariatric Patients (NCT03721497)

Eligibility criteria:
Inclusion Criteria:

          -  Eligible for bariatric surgery according to the Danish national criteria (i.e. aged
             18-60 years, BMI >35 kg/m2 with specific secondary disease or BMI >40 kg/m2 with
             significant health issues assessed by the multidisciplinary bariatric team) [42]

          -  Caucasian men

          -  Total testosterone < 12.0 nmol/l

          -  No contraindications for testosterone treatment

        Exclusion Criteria:

          -  Previously diagnosed with prostate, mammae or liver cancer. Any other cancer within
             the last 5 years.

          -  Hypersensitivity to the active substance or to any of the excipients in Nebido®

          -  Symptomatic heart disease NYHA >2

          -  Recently thromboembolic disease <3 months

          -  PSA >4.0 ug/l or PSA>3.0 ug/l and lower urinary tract symptoms

          -  Disability that severely affect the ability to perform exercise training

          -  EVF > 52%
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? 0
Clinical trial: A Safety and Efficacy Study of Alefacept in the Treatment of Moderate to Severe Erosive Mucosal Lichen Planus (NCT00135733)

Eligibility criteria:
Key Inclusion Criteria:

          -  Written informed consent, authorize release and use of protected health information

          -  At least 18 years of age

          -  Diagnosis of moderate to severe mucosal lichen planus

          -  No systemic (oral or injectable) treatment of lichen planus for 4 weeks prior to
             starting study drug.

          -  Willing to forgo changes in topical treatment (creams) for 4 weeks before receiving
             the study drug and during the course of the study.

          -  Off of topical tacrolimus or pimecrolimus for 4 weeks prior to starting the study drug

          -  CD4+ T lymphocyte counts must be above the lower limit of normal laboratory value

        Key Exclusion Criteria:

          -  Clinically significant abnormal laboratory values

          -  Skin lesions currently undiagnosed, but suspicious for malignancy

          -  Other skin disease that might interfere with lichen planus status assessments.

          -  History of malignancy other than basal cell carcinomas or fewer than 3 squamous cell
             carcinomas

          -  Exposure to systemic therapy for lichen planus within 4 weeks prior to enrollment.

          -  Previous exposure to alefacept
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? 0
Clinical trial: Earlier Triggering in Rec-FSH/GnRH Antagonist Cycles (NCT01390207)

Eligibility criteria:
Inclusion Criteria:- Age ≤ 39 years

          -  Body mass index between 18 and 29 kg/m²¬

          -  Presence of both ovaries

          -  Basal levels of estradiol (≤ 80 pg/ml) and progesterone (≤ 1.6ng/ml) on day one of the
             cycle

          -  Treatment with IVF/ICSI

          -  Embryo transfer on day 3 (1 or 2 embryos)

          -  Patients can enter in the study only once

        Exclusion Criteria:

          -  Presence of endometriosis stage ≥3(AFS)

          -  Polycystic ovarian syndrome (Rotterdam criteria)

          -  Need for preimplantation genetic diagnosis (PGD)

          -  Azoospermia testicular sperm extraction (TESE)
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 39 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Progenitor Cells in Human Esophagus (NCT03108898)

Eligibility criteria:
Inclusion Criteria:

          -  ≥ 18 years old

          -  Esophagus surgery at Mayo Clinic

        Exclusion Criteria:

          -  <18 years old
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? 1
Clinical trial: Study to Evaluate the Efficacy and Safety of DWP14012 in Patients With Erosive Gastroesophageal Reflux Disease (Phase 2, Therapeutic Exploratory Study) (NCT03184324)

Eligibility criteria:
Inclusion Criteria:

          -  Adults between 20 and 75 years old based on the date of written agreement

          -  Those who have been diagnosed with erosive gastroesophageal reflux disease(EGRD) of LA
             Grade A-D on the upper gastrointestinal endoscopy

          -  Those who experienced symptoms of heartburn or acid reflux within the last 7 days

        Exclusion Criteria:

          -  Those who have undergone gastric acid suppression or gastric, esophageal surgery

          -  Those who with clinically significant liver, kidney, nervous system, respiratory,
             endocrine, hematologic, cardiovascular, urinary system disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 0
Clinical trial: Correlation Between Epistaxis and Cardiovascular Disease (NCT02677467)

Eligibility criteria:
Group A

        Inclusion Criteria:

          -  age is over 18 with spontaneous epistaxis

        Exclusion Criteria:

          -  they needs immediately treatment for hypertensive urgency.

          -  they don't want to participate in this investigation.

        Group B

        Inclusion Criteria:

          -  age is over 18 with bleeding of wound

        Exclusion Criteria:

          -  their wounds' condition is serious or their pain is much severe.

          -  they don't want to participate in this investigation.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? 1
Clinical trial: Cholesterol-Lowering Atherosclerosis Study (CLAS) (NCT00000599)

Eligibility criteria:
Non-smoking men, ages 40 to 59, with progressive atherosclerosis confirmed by angiography,
        who had coronary bypass surgery at least three months prior to the study admission date,
        and who had entry fasting blood cholesterol levels in the range of 185
Male
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 59 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 0
Clinical trial: Prevalence and Clinical Characteristics of Patients With Jackhammer Esophagus and Symptoms of Gastroesophageal Reflux Disease (NCT03347903)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with symptoms of gastroesophageal reflux disease and diagnosis of Jackhammer
             esophagus

        Exclusion Criteria:

          -  patients not willing to participate data or undergo screening for gastroesophageal
             reflux disease
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 1