Clinical trial: Alveolar Management Following Teeth Extraction (NCT03089619)

Eligibility criteria:
Inclusion Criteria:

          -  Signed informed consent

          -  Indication for tooth extraction resulting in a edentulous gap

          -  Male and female patients with an age range 20-60 years

          -  Caucasian

          -  For female patients: a negative pregnancy test

          -  Normotonic blood pressure (according to the WHO definition):

               -  Men: 110/70 - 140/90 mm Hg

               -  Women: 100/60- 140/90mm Hg

        Exclusion Criteria:

          -  Parallel implantation of another implant

          -  Parallel planned prosthetic restoration of the adjacent teeth

          -  Smoker (less than 5 years non-smoker)

          -  Nursing women

          -  Participation in another clinical trial which dates back to less than 3 months before
             inclusion in this clinical trial

          -  Intake of bisphosphonates

          -  Radiation therapy (medical history or current)

          -  Known Diabetes mellitus

          -  Inflammatory processes in the mouth (PSI> 2)

          -  Presence of autoimmune diseases (Rheumatoid arthritis, Sjögren's syndrome, Systemic
             lupus erythematosus)

          -  Presence of blood coagulation disorders (Haemophilia A/B), or the intake of
             anticoagulants (Warfarin, new oral anticoagulants, aspirin> 100 mg)

          -  Osteogenesis imperfecta

          -  Osteoporosis

          -  Leukemia

          -  Agranulocytosis

          -  Immunocompromised patients

          -  Acute phase and rehabilitation phase of myocardial infarction

          -  Oncogenes diseases

          -  Patients undergoing chemotherapy

          -  Sepsis

          -  Acute and chronic infections: sinusitis, rhinitis, pharyngitis and Otitis media

          -  Wound healing disorders

          -  Seizures

          -  Gingival hyperplasia

          -  Alcohol abuse

          -  Drug abuse

          -  Infectious diseases (HIV, Hepatitis B and C)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0