araag2/NLI4PR huggingface dataset:
Clinical trial: Zinc Sulfate in the Treatment of Rosacea: A Randomized, Controlled Trial (NCT00395226)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of facial rosacea made or confirmed by one of the investigators.

          -  Severity of signs of rosacea "greater than mild" at the time of enrollment.

        Exclusion Criteria:

          -  Treatment for rosacea during the 3 months prior to enrollment.

          -  Use of zinc dietary supplement > 25 mg per day during the 3 months prior to enrollment
             ( Most patients taking multivitamins with Zinc, often 15 mg per day, will not be
             excluded, whereas most patients taking additional Zinc supplements, often 25-50 mg per
             day or more will be excluded.)

          -  Diagnosis of rosacea fulminancy.

          -  Pregnant or breast feeding.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? 1
Clinical trial: Protocol for the Determination of Menstrual Losses in Healthy Women With Apparently Normal Cycles (NCT01276964)

Eligibility criteria:
Inclusion Criteria:

          -  Women in the fertile age (between 20-45 years), not assuming oral contraceptives from
             at least three months

          -  Referred normal menses .Use of the same brand of sanitary protection wear for the
             whole of the period.

          -  BMI between 18 and 30

        Exclusion Criteria:

          -  Abnormal Bleeding Score

          -  Positive gynecological history of fibroids, polyps or malignancy

          -  Treatment with anti-coagulants, antifibrinolytics, non steroidal anti-inflammatory
             agents

          -  Use of oral contraceptives in past three months

          -  Use of intrauterine devices (IUDs) in past three months .Hgb levels <12 g/dl and
             Ferritin <25 ng/ml.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: A Clinical Trial to Test the Saftey and Success Rate for a Cerrumen Cleaning Device - "Wondertip". (NCT03019380)

Eligibility criteria:
Inclusion Criteria:

          -  Patients over 1 year old who have cerumen impaction.

        Exclusion Criteria:

          -  external ear infection

          -  chronic otitis media with perforation of the tympanic membrane

          -  past ear surgery

          -  otorrhea

          -  inflamation of the auricle or the periauricular region

          -  temporal bone neoplasm

          -  deafness in the contralateral ear (single sided deafness).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Year old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? 0
Clinical trial: Inpatient Physical Activity Function Through Enhanced Participation Levels in Animal-Assisted Therapy Programs (NCT02606006)

Eligibility criteria:
Inclusion Criteria:

          1. Are being rehabilitated as an inpatient for Parkinson's, stroke, or generalized
             weakness deconditioning (muscle weakness);

          2. Are able to give informed consent or communicate either verbally or in writing;

          3. Are able to follow instructions;

          4. Are at least 18 years old; and

          5. Choose to participate.

        Exclusion Criteria:

          1. Have a fear/dislike of dogs;

          2. Show noticeable cues of resistance/discomfort to dogs;

          3. Are allergic to dogs;

          4. Are immunocompromised;

          5. Are not being rehabilitated for Parkinson's, stroke, or generalized weakness
             deconditioning (muscle weakness);

          6. Are not able to give informed consent or communicate either verbally or in writing;

          7. Are not able to follow instructions;

          8. Do not speak English;

          9. Are not at least 18 years old; and

         10. Do not choose to participate.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 0
Clinical trial: Pulmonary Fibrosis and Telomerase Mutation Study (NCT01501578)

Eligibility criteria:
Inclusion Criteria:

          -  Diffuse interstitial lung disease on CT scan

          -  Telomerase mutation analysis

        Exclusion Criteria:

          -  Presence of connective tissue disease, or pneumoconiosis or drug induced lung disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? 0
Clinical trial: Patient-Reported Outcome Of Facial Erythema (PROOF) (NCT01885000)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female subjects age of 18 years or older,

          -  A clinical diagnosis of facial rosacea,

          -  A Patient Self-Assessment score of 4 (severe) at Baseline prior to the study drug
             application,

          -  A Clinician's Erythema Assessment (CEA) score of 3 (moderate) or 4 (severe) at
             Baseline prior to the study drug application,

        Exclusion Criteria:

          -  More than 5 facial inflammatory lesions (papules or pustules) of rosacea,

          -  Any uncontrolled chronic or serious disease or medical condition that may either
             interfere with the interpretation of the clinical trial results, or put the subject at
             significant risk if the subject participates in the clinical trial as judged by the
             investigator,

          -  Known or suspected allergies or sensitivities to any component of the study drugs,
             including the active ingredient brimonidine tartrate (see Investigator's Brochure),

          -  Female who is pregnant or lactating.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? 1
Clinical trial: Effect of Perioperative Intravenous Lidocaine on Opioid Consumption and Pain After Laparoscopic Totally Extraperitoneal Inguinal Hernioplasty (NCT02601651)

Eligibility criteria:
Inclusion Criteria:

          -  Male patients with American Society of Anaesthesiologists physical status (ASA PS) I
             and II of age 18 to 65 years

          -  Patients undergoing laparoscopic totally extraperitoneal repair for
             unilateral/bilateral inguinal hernia.

        Exclusion Criteria:

          -  Refusal to give consent.

          -  ASA physical status III or more.

          -  Inability to comprehend pain assessment score or severe mental impairment

          -  Patient who weighed < 40 kg or >100 kg

          -  Severe underlying cardiac rhythm disorder

          -  Renal or hepatic disease

          -  Allergic to local anaesthetics

          -  Epilepsy

          -  Patients on regular analgesics or anti-arrhythmic drugs
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 120 Days (SL120) (NCT01595646)

Eligibility criteria:
Inclusion Criteria:

          -  Age 50-89

          -  Diagnosed with mild cognitive impairment, or mild/moderate AD

        Exclusion Criteria:

          -  Excessively high or low blood pressure, heart rate

          -  Pre-existing diabetes not controlled by exercise/diet

          -  Previous/current use of insulin

          -  Significant elevations in lipids, liver enzymes

          -  Menstrual period within the last 12 months

          -  Significant neurological or medical disorder (other than AD)

          -  Significant use of nasal decongestants

          -  Current use of anti-psychotic, anti-convulsive, anxiolytic, glucocorticoids, or
             sedative medications
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 89 Years

Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 0
Clinical trial: Single-Arm Study To Evaluate The Efficacy and Safety of Valoctocogene Roxaparvovec in Hemophilia A Patients at a Dose of 4E13 vg/kg (NCT03392974)

Eligibility criteria:
Inclusion Criteria:

          1. Males ≥ 18 years of age with hemophilia A and residual FVIII levels ≤ 1 IU/dL as
             evidenced by medical history.

          2. Must have been on prophylactic FVIII replacement therapy for at least 12 months prior
             to study entry.

          3. Treated/exposed to FVIII concentrates or cryoprecipitate for a minimum of 150 exposure
             days.

          4. No previous documented history of a detectable FVIII inhibitor of less than 0.6
             Bethesda Units (BU).

        Exclusion Criteria:

          1. Detectable pre-existing antibodies to the AAV5 capsid.

          2. Any evidence of active infection or any immunosuppressive disorder, including HIV
             infection.

          3. Significant liver dysfunction, prior liver biopsy showing significant fibrosis, liver
             cirrhosis of any etiology or history of hepatic malignancy.

          4. Evidence of any bleeding disorder not related to hemophilia A.

          5. Active Hepatitis C.

          6. Prior treatment with any vector/gene transfer agent.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1
Clinical trial: Hearing Results and Post Surgical Outcomes Using Amniotic Membrane Allograft vs. Fascia for Tympanoplasty (NCT03028272)

Eligibility criteria:
Inclusion Criteria:

          1. Presence of a tympanic membrane perforation

          2. Patient at PI's clinic

        Exclusion Criteria:

          1. Presence of cholesteatoma

          2. Prior surgery on the same-sided TM or middle ear

          3. Ossicular chain abnormalities

          4. Congenital deformities involving the middle ear or eustachian tube

          5. Refusal to undergo surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 3 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? 0