araag2/NLI4PR huggingface dataset:
Clinical trial: Quantifying and Understanding the Signs and Symptoms of Fever (NCT01287143)

Eligibility criteria:
-  INCLUSION CRITERIA PHASE I:

        Adult and pediatric medical-surgical patients hospitalized in the Clinical Center, NIH
        admitted to 3NE (oncology/ transplant), 3NW (surgical oncology) and 1NW (pediatrics).

        Oriented to person, time and place at time of interview

        Active fever (body temperature greater than or equal to 38.0 Celsius), treated or
        untreated, within the last 12 hours.

        Willingness to participate in a short interview (15-20 minutes) about their symptoms

        Understands and speaks English

        Age 8 years and older

        INCLUSION CRITERIA FOR STUDY OF FEBRILE ASSESSMENT TOOL:

        Adult (18 years of age or greater) medical-surgical patients hospitalized at the Clinical
        Center and admitted to 3NW.

        Oriented to person, time and place at time of admission

        Willingness to be asked about their symptoms of fever during vital signs assessment

        Understands and speaks English

        INCLUSION CRITERIA PHASE II:

        Inpatients admitted to the Clinical Center

        Age 8 years and older
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 100 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: The Effect of Cryotherapy in Pain Control, Function and Quality of Life in Individuals With Knee Osteoarthritis (NCT02725047)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with knee osteoarthritis based on clinical and radiographic criteria of
             American College of Rheumatology

          -  Osteoarthritis signals in at least one of the compartments of the knee joint
             (tibiofemoral and / or the patellofemoral joint)

          -  Do not perform regular physical activity - less than three times a week regularly

          -  Grade 2 or 3 according to the criteria of Kellgren & Lawrence knee osteoarthritis
             radiographic examination scale.

          -  Minimum score of 4 cm in Visual Analogue Scale (total 10 cm)

          -  Body Mass Index less or equal to 45 kg/cm2

        Exclusion Criteria:

          -  Physical therapy within 3 months prior to the research project

          -  Corticosteroid injection in the knee (in the previous 6 months)

          -  Medical condition (cardiorespiratory, neurological and / or musculoskeletal)

          -  Previous ankle, knee or hip surgery
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Tunneled Pleural Catheter in Partially Entrapped Lung (NCT00637676)

Eligibility criteria:
Inclusion Criteria:

          -  One-sided malignant pleural effusion, first occurrence, or following repeated
             pleuracentesis

          -  History of dyspnea relieved after pleuracentesis

          -  Patient is suitable for VATS

          -  Surgery is indicated by diagnostic necessity

          -  Ability of subject to understand character and individual consequences of clinical
             trial

          -  Written informed consent must be available before enrolment in the trial

          -  For women with childbearing potential, adequate contraception.

          -  Histological proven pleural carcinosis by immediate sectioning

          -  Intraoperative: partial entrapment of the lung

        Exclusion Criteria:

          -  Prior lobectomy or pneumonectomy on the affected side

          -  The patient is not operable for general reasons or Karnofsky performance score < 50

          -  Intraoperative suspicion of a pleural empyema

          -  Chylothorax

          -  Prior attempts at pleurodesis

          -  Intended or prior intrapleural chemotherapy or radiotherapy

          -  Pregnancy and lactation

          -  Participation in other competing clinical trials and observation period of competing
             trials
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? 1
Clinical trial: Exercise Versus DDAVP in Patients With Mild Hemophilia A (NCT03379974)

Eligibility criteria:
Inclusion Criteria:

          -  1) Patients of ≥13 years of age and ≤21 years of age with MHA (FVIII:C level of ≥6% to
             ≤50%).

        Exclusion Criteria:

          1. A currently circulating or a history of inhibitor (0.5 BU on two or more occasions).
             Inhibitor development is rare in MHA.

          2. History of FVIII infusion (both standard-acting and extended half-life products) or
             DDAVP use in preceding 1 week. Patients will be instructed to hold factor use or DDAVP
             for 1-week prior to participation in study, except for management of acute bleeds, in
             which case they will be instructed to inform the PI via telephone or e-mail.

          3. Patients with severe arthropathy (as determined by the principal investigator)
             interfering with ability to exercise. Severe arthropathy is rare in MHA.

          4. Patients on beta-blockers, anti-platelet agents or regular non-steroidal
             anti-inflammatory medications (e.g. Celebrex).

          5. Patients who are active smokers (cigarettes, marijuana).

          6. Patients with a history of a recent bleed (in preceding 2 weeks) in any location or a
             joint/muscle bleed in the lower limbs in the preceding 4 weeks.

          7. Co-existence of a congenital bleeding disorder other than MHA (e.g. VWD).

          8. Patients with an active infectious or inflammatory condition. This includes previously
             identified HIV, active hepatitis B or C as reflected in elevated AST, ALT, RNA
             positivity for hepatitis B or C. HIV, hepatitis B and C are very rare in the age group
             (13-21 years) we hope to accrue in the proposed study.

          9. Patients who for medical reasons should not receive DDAVP [those with renal or CNS
             disease (e.g. brain tumor)] or have previously experienced adverse events with DDAVP
             (e.g. hypotensive event, seizure).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 21 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1
Clinical trial: The Efficacy of Tranexamic Acid in the Treatment of Lichen Planus Pigmentosus and Erythema Dyschromicum Perstans (NCT04233749)

Eligibility criteria:
Inclusion Criteria:

          -  Subject age 18 and older

          -  Subject with a diagnosis of LPP, EDP, or AD

          -  Subject able to understand requirements of the study and risks involved

          -  Subject able to sign a consent form

          -  Subject to have discontinued all topical or oral medications, with the exception of
             sunscreen, used to treat pigmentary abnormalities one month prior to treatment

        Exclusion Criteria:

          -  Personal history of clotting disorder or thromboembolic disease (deep vein thrombosis
             (DVT), stroke, etc)

          -  Active malignancy, excluding non-melanoma skin cancer

          -  Moderate to severe renal impairment

          -  History of migraine with aura

          -  Current anticoagulant therapy

          -  Current use of hormonal contraception or hormone replacement therapy in the last 30
             days

          -  A woman who is lactating, pregnant, or planning to become pregnant
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? 0
Clinical trial: Examining Social, Emotional, and Cognitive Functioning in People With Fragile X and Down Syndromes (NCT00879515)

Eligibility criteria:
Inclusion Criteria:

          -  Fragile X premutation or fragile X syndrome, measured by DNA testing; Down syndrome,
             confirmed by chromosomal analysis; or normally developing control

          -  Normal hearing
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 5 Years old.
Subject must be at most 25 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? 1
Clinical trial: RCT Comparing 21 and 22 G Needle in the Diagnosis of Sarcoidosis by EBUS TBNA (NCT02459431)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥18 years

          -  Clinicoradiological suspicion of sarcoidosis where endobronchial ultrasound guided
             transbronchial needle aspiration is contemplated

          -  Enlarged hilar and mediastinal lymph nodes >10 mm (any axis) on computed tomography of
             the chest

        Exclusion Criteria:

          -  Hypoxemia (SpO2 <92%) on inspired fraction of oxygen 0.3

          -  Treatment with systemic glucocorticoids for more than 2 weeks in the preceding three
             months

          -  Diagnosis of sarcoidosis possible with another minimally invasive technique such as
             skin biopsy or peripheral lymph node biopsy

          -  Failure to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 99 Years

Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? 0
Clinical trial: Trans-Middle-Ear Mucosal Gas Exchange Project 1, Specific Aim 1 (NCT01925482)

Eligibility criteria:
Inclusion Criteria:

          -  Otherwise healthy adults aged 18 to 50 years

          -  No history of significant ME disease; intact tympanic membrane (Group 1 only)

          -  Functional tympanostomy tube or chronic perforation after tube extruded; tube placed
             for middle-ear effusion/Eustachian tube dysfunction (Group 2)

          -  No history of past ME surgeries other than ventilation tubes (Group 2),

          -  Able to comprehend study risks and provide written Informed Consent

        Exclusion Criteria:

          -  Have any chronic health problem

          -  Have ME fluid or otitis media (OM)at the time of presentation for ventilation tube
             insertion (Group 1 only)

          -  Have drainage through the ventilation tube at the time of testing

          -  Have a cold or allergic rhinitis at the time of testing

          -  Taking any prescription drug with the exception of those for birth control

          -  Have a known or suspected allergy/adverse reaction to any of the study drugs use to
             prepare the tympanic membrane for ventilation tube insertion (Group 1 only)

          -  Have a hearing threshold >15 dB or a >10 dB air-bone gap at any of the speech
             frequencies (Group 1 only)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? 0