araag2/NLI4PR huggingface dataset:
Clinical trial: Efficacy and Safety Study of Norethindrone Acetate Transdermal Delivery System in Contraception (NCT01140217)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy females

          -  18-45 years

          -  Regular, consistent menstrual cycles between 25 and 35 days

          -  Sexually active and at risk of becoming pregnant

        Exclusion Criteria:

          -  History of infertility

          -  Known contraindications to progestogen administration

          -  Pap smear suggestive of a high-grade precancerous lesion(s)

          -  Clinically significant deviation from normal in any of the screening tests or exams
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 1
Clinical trial: Assessment of the Transfer of Using Levonorgestrel Intrauterine System (LNG IUS) as a Contraceptive to Using it as Part of Hormone Replacement Therapy (HRT). (NCT00185458)

Eligibility criteria:
Inclusion Criteria:

          -  Women with intact uterus, regular menstrual cycles and no previous or current
             climacteric symptoms.

        Exclusion Criteria:

          -  Pregnancy or lactation.

          -  Previous pelvic infections.

          -  Abnormal bleeding.

          -  Abnormal uterine cavity.

          -  Uterine polyps.

          -  Genital cancer.

          -  Liver diseases.

          -  Alcoholism or drug abuse.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 46 Years old.
Subject must be at most 51 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Sedation During Spinal Anesthesia (NCT03133780)

Eligibility criteria:
Inclusion Criteria:

          -  Male patients aged from 18 to 40 years old undergoing elective unilateral inguinal
             hernia repair with no neurological, cardiovascular and hepato-renal abnormalities.

        Exclusion Criteria:

          -  Age: younger than 18 or older than 40.

          -  Psychatric or neurological disorders.

          -  Cardiovascular disorders.

          -  Coagulation disorders.

          -  Contraindications to neuraxial block (allergy to L.A, peripheral neuropathy, prior
             spine surgery).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 0
Clinical trial: Validation of a Specific Measure for Assessment of Compliance With Treatment in Patients With Hemophilia (NCT02582450)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with hemophilia A and B

          -  Patients who have previously signed the informed consent document

        Exclusion Criteria:

          -  Patients with other congenital coaghulopatías (eg, Von Willebrand's disease)

          -  Patients with cognitive impairment, or oral or written understanding
Male
No healthy subjects accepted to join the trial.
Subject must be at least 13 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1
Clinical trial: A Comparison of Testicular Volume and Blood Flow in Patients With Inguinal Hernia, Hydrocele, and Cord Cyst (NCT03033381)

Eligibility criteria:
Inclusion Criteria:

          -  Our analysis included boys who were younger than 17 years and possessing one-sided
             inguinal hernia, hydrocele, or cord cyst and who were otherwise healthy.

        Exclusion Criteria:

          -  Patients who had bilaterally inguinal hernia, hydrocele, or cord cyst
Male
No healthy subjects accepted to join the trial.

Subject must be at most 17 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 0
Clinical trial: Glucocorticoid Withdrawal Syndrome in Patients With Treated Cushing Syndrome (NCT04543253)

Eligibility criteria:
Inclusion Criteria:

          1. age 18 and above,

          2. new diagnosis of CS of any of the three subtypes (pituitary, adrenal or ectopic CS),
             and MACS,

          3. planning for a curative surgery

          4. ability to provide informed consent.

        Exclusion Criteria:

          1. systemic supraphysiological GC for any reason within 1 month of enrollment, for more
             than 2 weeks,

          2. inability to provide informed consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the office due to weight gain and fatigue.  He is not able to lift heavy objects or climb stairs. Family history is positive for DM type 2 and HTN in his father.  Blood pressure is 165/90 mm Hg and pulse is 85/min.  On physical examination, there is symmetric proximal muscle weakness of the upper and lower extremities.  Fasting plasma glucose level is 138 mg/dL and 24-hour urinary cortisol is twice the upper normal limit.  Further evaluation reveals that high-dose, but not low-dose, dexamethasone suppresses serum cortisol levels.  Serum ACTH levels are high-normal. This patient's findings are consistent with endogenous Cushing Syndrome.

Patient description (patient's own words): I'm a 47-year-old man. I went to the clinic because I had been gaining weight and had increased fatigue over the past few weeks. I was not able to lift heavy objects or even climb the stairs. My dad was diagnosed with type 2 diabetes and high blood pressure. During the exam, they took my blood pressure, which was 165/90 mm Hg, and my pulse was 85/min. They found out that I have weaknesses in both of my arms and legs. I also did a blood test on an empty stomach, and I had a glucose level of 138 mg/dL, and twice the upper normal limit of cortisol. I had high-normal levels of ACTH. The doctor said I suffer from endogenous Cushing Syndrome.

Does the patient match the trial criteria? 0
Clinical trial: Assessment of Gastro-esophageal Reflux Using Endo-Flip vs Bravo (NCT00481949)

Eligibility criteria:
Inclusion Criteria:

          -  Provision of written, fully informed consent to undergo mechanistic procedures:
             Endo-FLIP, endoscopy and biopsy, 4 day wireless pH monitoring by the Bravo system

          -  All subjects should be off acid suppression medication (e.g. PPI, H2RA) for at least 5
             days prior to endoscopy

        Exclusion Criteria:

          -  Significant gastrointestinal symptoms or disease other than reflux

          -  Previous upper GI surgery or interventions such as oesophageal dilatations

          -  Predominant symptoms of motility disorders, e.g. dysphagia

          -  Presence of major oesophageal dysmotility on manometry, e.g. achalasia

          -  Significant co-morbidity requiring ongoing treatment or investigation

          -  Physical, neurological or psychiatric conditions preventing repeated visits to
             hospital or compliance with study procedures (e.g. physical impairment/reduced
             mobility)

          -  Pregnant at the time of enrolment

          -  No haematological abnormalities (no anticoagulants)

          -  No medications influencing gastrointestinal function within 3 days of the study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 1
Clinical trial: Physical Activity Level of Norwegian Boys With Duchenne Muscular Dystrophy (NCT03947112)

Eligibility criteria:
Inclusion Criteria:

          -  Boys with conclusive diagnosis of Duchenne Muscular disease, attending Norwegian
             pediatric rehabilitation clinics.

          -  Signed written consent

          -  Able to answer questionnaires with help from parents, care giver(s) or health care
             professional with regular follow up of the participants.

        Exclusion Criteria:

          -  Lack of consent.

          -  Language difficulties

          -  Cognitive dysfunction or mental retardation leading to difficulties in answering the
             questionnaires adequately
Male
No healthy subjects accepted to join the trial.
Subject must be at least 6 Years old.
Subject must be at most 18 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 1
Clinical trial: Comparative Study of Strategies for Management of Duchenne Myopathy (DM) (NCT03633565)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of DMD confirmed by electromyogram (EMG) , Creatine phosphokinase (CPK)
             level and/ or DNA analysis or muscle biopsy.

          -  Male patients

          -  Age 5-15y.

          -  Ambulatory (loss of ambulation was only seen in those with baseline 6 Minute Walk
             Distance {6MWD} <325 meters.)

          -  No clinical evidence of heart failure.

        Exclusion Criteria:

          -  Female patients

          -  Any injury which may impact functional testing, e.g. upper or lower limb fracture.

          -  hypertension, diabetes,

          -  Wheelchair bound.

          -  Cardiac rhythm disorder, specifically: rhythm other than sinus, supraventricular
             tachycardia (SVT), atrial fibrillation, ventricular tachycardia.or heart failure (left
             ventricle ejection fraction {LVEF < 50%}.

          -  Continuous ventilatory support.

          -  Liver disease (acute, chronic liver disease)

          -  Renal impairment
Male
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 15 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 1
Clinical trial: Arthritis Research UK Gout Treatment Trial - Phase 2 (NCT01477346)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of gout

          -  At least one acute attack of gout within previous 12 months

        Exclusion Criteria:

        - Inability to give informed consent and known terminal or mental illness
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 1
Clinical trial: The LAVA (Lateral Flow Antigen Validation and Applicability) Study for COVID-19 (NCT04629157)

Eligibility criteria:
Inclusion Criteria:

          1. Children aged 0 - <18 years undergoing combined nose and throat swabbing for an
             elective diagnostic or surgical procedure.

          2. Children aged 0 - <18 years undergoing combined nose and throat swabbing on admission
             to hospital when there is a differential diagnosis of COVID-19.

          3. Children aged 0 - <18 years undergoing routine combined nose and throat swabbing
             during a stay on the intensive care unit, the high dependency unit or a transplant
             ward.

        Exclusion Criteria:

        None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 17 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0