araag2/NLI4PR huggingface dataset:
Clinical trial: Octanol to Treat Essential Tremor (NCT00080366)

Eligibility criteria:
-  INCLUSION CRITERIA:

             14 patients with a clinical diagnosis of essential tremor will participate in the
             study. Selection criterion is essential tremor with a history of ethanol
             responsiveness. Informed consent will be obtained by any of the co-investigators.

        Patients must be off any medications used to treat essential tremor such as mysoline or
        propranolol for at least 2 weeks. Patients must withhold ethanol and caffeine 24 hours
        prior to starting the treatment periods through the end of treatment periods, including
        alcohol or caffeine containing over the counter medications. Ethanol and caffeine
        consumption is allowed in the washout period.

        EXCLUSION CRITERIA:

        Patients with abnormalities on neurologic exam other than tremor.

        Patients with a history of chronic alcohol dependence.

        Patients with chronic medical conditions such as renal failure, hepatic failure and chronic
        lung disease.

        Patients on other medications that cannot be temporarily discontinued for the length of the
        study.

        Patients, who, for moral or religious reasons, do not wish to take a potentially
        intoxicating drug.

        Patients with abnormalities on their baseline screening laboratory tests.

        Women who are pregnant or lactating.

        Patients under the age of 21.

        Asians and Pacific Islanders.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 1
Clinical trial: Trial of Minocycline to Treat Children With Fragile X Syndrome (NCT01053156)

Eligibility criteria:
Inclusion Criteria:

          -  Must have fragile X syndrome with molecular documentation

          -  Current pharmacological treatment regimen has been stable for at least 4 weeks

        Exclusion Criteria:

          -  Subjects who plan to initiate or change pharmacologic or non-pharmacologic
             interventions during the course of the study

          -  subjects who are unable to take oral medication

          -  subjects who have been on minocycline previously

          -  subjects who are allergic to minocycline or tetracyclines

          -  subjects who are pregnant

          -  subjects with history of lupus or hepatic dysfunction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 42 Months old.
Subject must be at most 16 Years

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? 1
Clinical trial: Acute Low Back Pain in the Emergency Department Treated With Osteopathic Manipulative Treatment Versus NSAIDs (NCT04129437)

Eligibility criteria:
Inclusion Criteria:

          -  All patients 18 years of age or older with the chief complaint of acute low back pain
             defined as symptom duration no longer than four weeks prior to ED presentation and
             having clinical findings of somatic dysfunction (muscle edema, erythema, bogginess,
             hypertonic muscles, asymmetry of tissue, pain with movement, severe/sharp tenderness).

        Exclusion Criteria:

          -  Patients will be excluded if they previously participated in the study, history of
             gastrointestinal bleed, allergies to NSAIDs, NSAID use 4 hours prior to arrival,
             history of or concern for spinal column fracture, current diagnosis of active
             malignancy or metastatic cancer, open skin wounds at the treatment location site,
             patients with neurological deficits related to acute back pain, pregnant women,
             individuals unable to take oral medications, temperature >38C, prisoners, those unable
             to consent, subjects under police custody, nursing home residents, non-English
             speaking patients.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 57-year-old man comes to the emergency department due to constipation.  His last bowel movement was 2 days ago. He complains of spending about 30 minutes once attempting to defecate. He also has lower back pain.  There is no history of trauma. The pain is not relieved with over-the-counter pain medications.  His vital signs are within normal limits.  Examination shows low back pain that is worse with back flexion and raising of the legs; it radiates into his left leg.  Pinprick in the perianal area does not cause rapid contraction of the anal sphincter.  The rest of the neurologic examination is normal. He is suspected of Cauda Equina syndrome and referred to a spinal MRI.

Patient description (patient's own words): I'm a 57 year-old-man, and I had to go to the ER because I couldn't go defecate. My last trip to the toilet was 2 days ago, and I tried too many times, during 30 min, to get my poop to get out. I also have terrible lower back pain. The doctor did not notice any trauma. I tried to get the pain away using over-the-counter medications, but it simply did not work! Back in the ER my vitals were normal. My pain was even more intense with back flexion, and when I raised my legs, it radiated into my left leg. The doctor did an anus exam where he had to pinch it and it was not reacting! However the rest of my neurologic exam was normal. The doctor suspects a Cauda Equina syndrome and referred me to a spinal MRI.

Does the patient match the trial criteria? 0
Clinical trial: Once-A-Day Prophylaxis for Youth and Young Adults With Severe Hemophilia A (NCT00717626)

Eligibility criteria:
Inclusion Criteria:

          -  Severe hemophilia A (<1% factor VIII)

          -  Age 12 to 24 years inclusive

          -  Male

          -  No current factor VIII inhibitor (an inhibitor will be defined as ≥ 0.6 Bethesda
             Units) within the past year

          -  Able to participate in a home infusion program with adequate peripheral venous access
             as assessed ny the treating investigator

        Exclusion Criteria:

          -  Important co-morbidities (Acquired Immunodeficiency Syndrome or symptomatic HIV
             infection, symptomatic hepatitis B or C infection)

          -  Other concomitant acquired or congenital bleeding disorder (e.g. von Willebrand's
             Disease)

          -  Receiving factor VIII replacement through central venous catheter
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 24 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1
Clinical trial: Local or Regional or General Anesthesia for Hernia Repair: a Randomized Controlled Trial (NCT01845376)

Eligibility criteria:
Inclusion Criteria:

          -  Patients scheduled to undergo elective unilateral inguinal hernia repair at Siriraj
             Hospital will be undertaken.

          -  ASA I-III,

          -  Age greater than 18 years old

        Exclusion Criteria:

          -  Allergy to any medication used this study,

          -  Femoral hernia, recurrent hernia, bilateral hernia,

          -  Bleeding abnormalities,

          -  Severe hepatic, renal or cardiovascular disease,

          -  Chronic use of opioid,

          -  History of using steroidal or nonsteroidal anti-inflammatory drugs in the past 6
             months,

          -  Inability to communicate in Thai or to understand the purpose of the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: Bone Marrow Aspirate Compared to Platelet Rich Plasma for Treating Knee Osteoarthritis (NCT03289416)

Eligibility criteria:
Inclusion Criteria:

          -  Male or female age 18-80 years

          -  Knee osteoarthritis

          -  Subjects must present with pain or swelling to target knee for at least 4 months

          -  Kellgren-Lawrence score between 1 and 3 upon x-ray evaluation

          -  Must be willing and able to provide informed consent

          -  Willing and able to return for scheduled follow-up visits

        Exclusion Criteria:

          -  Major mechanical axis deviation of more than 50% into either compartment (varus or
             valgus )

          -  Have had a corticosteroid injection within 3 months or a hyaluronic acid injection
             within 6 months

          -  History of the following medical conditions:

          -  diabetes

          -  autoimmune disorders

          -  disorders requiring immunosuppression

          -  rheumatoid arthritis

          -  hemophilic arthropathy

          -  infectious arthritis

          -  Charcot's knee

          -  Paget's disease of the femur or tibia

          -  Cancer

          -  Ongoing infectious disease

          -  Significant cardiovascular, renal or hepatic disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Analysis of Bone Micro-Architecture as a Clinical Biomarker for Image-Based Fracture Risk Estimation. (NCT03463850)

Eligibility criteria:
Inclusion Criteria:

          -  Age 60 or greater Caucasian female with confirmed osteoporosis via prior DEXA.

          -  Patients with known vertebral fractures (Genant Grade 2 or higher) and with no
             fractures (Genant Score <2) from prior DEXA/VFA analysis will be recruited.

          -  Patients with fractures must have at least one lumbar vertebral body with no
             fracture(s) (as seen on prior DEXA scan) for analysis.

        Exclusion Criteria:

          -  Incidental finding to include pathology unrelated to osteoporosis that would directly
             affect bone architecture in the L spine (e.g. lytic bone lesions)

          -  Study DEXA scan reveals all lumbar vertebra have fractures (Genant >= 2)

          -  Orthopedic hardware in the lumbar spine region

          -  Unable to have a CT scan (e.g. too heavy for CT scan table, 660 lb. limit)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman

Does the patient match the trial criteria? 0
Clinical trial: The Arthritis, Diet, and Activity Promotion Trial (NCT00979043)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 60 years.

          -  BMI ≥ 28 kg/m2.

          -  Knee pain on most days of the month.

          -  Sedentary lifestyle pattern (<20 min exercise per week for last 6 months)

          -  Self-reported difficulty with at least one of the following: walking 1/4 mile,
             climbing stairs, kneeling, bending, stooping, shopping, lifting, self-care.

          -  Radiographic evidence of grade 1-3 knee osteoarthritis.

        Exclusion Criteria:

          -  Serious medical condition that precludes safe participation in exercise such as heart
             disease (angina, congestive heart failure), severe hypertension, COPD, renal or liver
             disease, insulin-dependent diabetes.

          -  Mini-mental state exam score <24.

          -  Inability to walks without a cane.

          -  Reported alcohol consumption >14 drinks/week.

          -  Inability to complete protocol.

          -  ST segment depression.

          -  Participation in another research study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 60 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 0
Clinical trial: Spectroscopic Evaluation of Middle Ear Infection (NCT04812093)

Eligibility criteria:
Inclusion Criteria:

          1. Male/ female at all age- newborn to adult.

          2. Non- pregnant woman.

          3. Diagnose of middle ear infection and plan for surgery procedure.

        Exclusion Criteria:

          1. Pregnant woman

          2. Incompetent adults (i.e. individuals with cognitive impairment)

          3. No diagnose of middle ear infection and no plan for surgery procedure.

          4. Adults with cognitive impairment and children of parents that are cognitively impaired
             and thus are unable to consent will be excluded from the study.
No condition on gender to be admitted to the trial.


Subject must be at most 21 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? 0