araag2/NLI4PR huggingface dataset:
Clinical trial: Arthritis in Assiut University Children Hospital (NCT04326582)

Eligibility criteria:
Inclusion Criteria:

        All patients Attending Rheumatology clinic and unit whom diagnosed as arthritis below the
        age of 18 years at the onset of presentation who have 1 or more of the following symptoms:
        swelling or limitation of motion of a joint , morning stiffness and arthralgia during the
        day, joint pain or abnormal joint use, history of school absences or limited ability to
        participate in physical education.

        Exclusion Criteria:

          -  Bone or joint trauma

          -  Hematological disorder (Leukemia, sickle cell disease, thalassemia or hemophilia).

          -  Patients with chronic diseases (Renal and hepatic diseases).
No condition on gender to be admitted to the trial.

Subject must be at least 3 Months old.
Subject must be at most 18 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 0
Clinical trial: Tissue Flossing in Tennis Elbow Patients (NCT03834077)

Eligibility criteria:
Inclusion Criteria:

          -  Elbow pain for at least 6 weeks and satisfy the widely accepted diagnostic criteria of
             lateral epicondylalgia.

          -  Diagnostic criteria are pain over the lateral humeral epicondyle that is provoked by
             gripping activities.

          -  Reduced grip strength and increased sensitivity to manual palpation over the lateral
             epicondyle.

          -  Pain with stretching or contraction of the wrist extensor muscles.

        Exclusion Criteria:

          -  Upper limb fractures, surgery or concomitant disease.

          -  Red flags presence.

          -  Mental disorders.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 17-year-old male comes to the office due to several months of right elbow pain.  The pain is worse with activity and limits his workouts and activities.  He has tried over-the-counter medications with limited relief.  Medical history is notable for eczema, and current medications include a topical hydrocortisone ointment.  He is sexually active with his girlfriend and uses condoms. He does not smoke or drink alcohol. He plays tennis most of the days of the week. The comprehensive evaluation shows pain on the lateral side of the elbow, made worse by pressure applied on the lateral epicondyle of the humerus and when making a fist with the elbow joint straightened. The patient has this pain since last year and had several courses of physical therapy.

Patient description (patient's own words): I'm 17, and I had to go to the doctor because I've been suffering from my right elbow for several months. The pain is even worse when I do sports and it kind of limits me for my workouts and activities. I tried over-the-counter medications but it didn't work much. I had eczema before and my medication is ointments that contain cortisone. I am sexually active as a 17-year-old guy, and I have a girlfriend, and we use condoms. I don't smoke or drink. I play tennis most days of the week. I did an exam that showed pain on the side of my elbow and it was worse when they applied some pressure on it and when I was putting my hand as a fist. I have had this pain since last year, and I had several sessions of physical therapy already.

Does the patient match the trial criteria? 0
Clinical trial: S Ketamine Use in Total Abdominal Hysterectomy (NCT02543385)

Eligibility criteria:
Inclusion Criteria:

          -  Females above the age of 21 years old scheduled undergoing open abdominal hysterectomy
             with remifentanil-propofol TCI in KKH for benign condition (fibroids, adenomyosis),

          -  Be willing and able to give written informed consent for participation in this study

          -  ASA I/II patient's.

        Exclusion Criteria:

          -  Patient with contraindications to the use of S+ketamine, as listed in the product
             label e.g. untreated or insufficiently treated thyroid hyperfunction, unstable angina
             pectoris or myocardial infarction within the last 6 months, diseases of the CNS,
             increased intraocular pressure and perforating ocular injuries, surgical procedures in
             the upper respiratory tract, etc

          -  Patients with a h/o drug or alcohol abuse

          -  Regular use of analgesics, or use of opioids within 12 hours of surgery

          -  Patient on chronic use of benzodiazepine or neurololeptics

          -  Patient on thyroid replacement hormone

          -  H/o IHD,HTN,Thyroid disorder.

          -  BMI> 30kg/m2.

          -  H/o Psychiatric disorder.

          -  Laproscopic surgery converted to open surgery.

          -  Pregnant or breast feeding female's.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 1
Clinical trial: Evaluate the Effect of Growth Hormone (GH) Treatment on Fibroblast Growth Factor 23, a Known Phosphaturic Agent (NCT00334945)

Eligibility criteria:
Inclusion Criteria:

          -  Twenty children with significant short stature < 3rd percentile, ages 3-14 years, and
             referred to Children's Hospital of Alabama

          -  Normal healthy volunteer children 3-18 years with normal stature

        Exclusion Criteria:

          -  Patients on medication including GH

          -  Patients with concomitant hormonal abnormalities

          -  Patients with disorders of calcium and phosphate metabolism

          -  Active neoplasms

          -  Closed epiphysis

          -  Known bone disorders
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 3 Years old.
Subject must be at most 14 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 0
Clinical trial: Determinants of Efficacy of EsophyX Treatment in Gastro-Esophageal Reflux Disease (NCT00498082)

Eligibility criteria:
Inclusion Criteria:

          -  Patients being considered for EsophyX treatment of GERD
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 1
Clinical trial: Effect of Exercise on Spread of the Miconozole Nitrate OVULE in the Vagina (NCT00194324)

Eligibility criteria:
Inclusion Criteria:

          -  Not at risk for pregnancy

          -  Willing to abstain from intercourse 24 hours prior to MRI

          -  Regular menstrual cycles (every 23-38 days)

          -  At least 10 weeks from most recent pregnancy outcome and had 2 spontaneous menstrual
             cycles since

          -  Normal pap smear within previous 12 months

          -  Negative test for yeast, bacterial vaginosis and trichomonas

          -  Not allergic to any component of the formulation

          -  No contraindications to MRI

          -  Not participated in another investigational trial within 30 days

          -  No history of condition, or finding on exam, that, in the opinion of the investigator,
             would make participation unsafe for the volunteer or complicate interpretation of the
             data
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 1
Clinical trial: Traditional Chinese Medicine Formula in the Treatment of Osteoarthritis of Knees or Hips. (NCT04110847)

Eligibility criteria:
Inclusion Criteria:

          -  1. Age ≥20 years old 2. Written informed consent obtained 3. Been diagnosed with knee
             or hip osteoarthritis 4. The physician interpretation of X-ray identification and
             joint space narrowing or bone spurs confirmed 5. In randomized trials before entering
             if used steroids or non-steroid medications osteoarthritis stable doses required at
             least one week 6. The WOMAC osteoarthritis index of the degree of pain assessment in
             the past two weeks at least> 4ppm pain

        Exclusion Criteria:

          -  1. Pregnant or breast-feeding women. 2. Chemotherapy or radiation therapy in cancer
             patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 1
Clinical trial: Hirschsprung Disease Genetic Study (NCT00478712)

Eligibility criteria:
Inclusion Criteria:

        - Individuals with Hirschsprung disease and their first degree relatives (any segment
        length of disease, with or without other congenital anomalies or health problems, single or
        multiple affected individuals in family)

        Exclusion Criteria:

          -  Unable or unwilling to provide sample for genetic studies

          -  Individual, parent, or guardian unable to comprehend and provide informed consent
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers

Subject must be at most 100 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? 1
Clinical trial: Effect of Hericium Erinaceus on Clinical Patients With Hearing Impairment (NCT03632512)

Eligibility criteria:
Inclusion Criteria:

          -  Patients aged 50 to 79 years old with symmetric sensorineural hearing loss, subjective
             sensorineural tinnitus, and all frequencies differed of ears less than 15 dB.

        Exclusion Criteria:

          -  Patients with abnormal liver and kidney function, normal hearing, severe and very
             severe hearing loss, no tinnitus or non-subjective sensorineural tinnitus, moderate or
             more cognitive impairment , patients unable to understand the details of this study or
             patients unable to co-examine, history of alcohol or drug abuse, history of high
             ambient noise exposure, bone tone air gap of pure tone hearing threshold greater than
             10 dB, and audiogram 4 kHz air conduction threshold greater than 8 kHz, 20 dB airway
             threshold, hearing impairment before age 30, and inability to understand the details
             of this study.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 79 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? 0
Clinical trial: A Comparative Pharmacokinetic and Pharmacodynamic Study of Sildenafil in Adult Smokers and Non Smokers (NCT04100759)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy male subjects

          -  Age 18-55 years.

          -  Ideal weight with ideal body mass index(BMI).

          -  Non-contributory history and normal physiological examination.

          -  Laboratory data within normal limits.

          -  Performance and compliance.

          -  The subjects should be without known history of alcohol or drug abuse problems

          -  Subjects who are cigarette smokers

          -  Subjects who are cannabis smokers

          -  Subjects who are non-smokers

        Exclusion Criteria:

          -  A known hypersensitivity to the drug.

          -  Gastrointestinal diseases.

          -  Auto immune diseases.

          -  Renal diseases or dysfunction.

          -  Cardiovascular disease of any type.

          -  Pancreatic disease including diabetes.

          -  Hepatic disease.

          -  Hematological, osteopathic, or pulmonary disease.

          -  History of alcoholism or drug abuse.

          -  Serious Psychological illness.

          -  Positive HIV.

          -  Abnormal (out of range) laboratory values.

          -  Subject who have taken any medication less than two weeks of the trials starting date.

          -  Subject who have donated blood or who have been in multiple dosing studies requiring a
             large volume of blood (more than 500 ml) to be drawn within six weeks preceding the
             start of the trials.
Male
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the clinic for his routine checkup. The patient wears glasses for myopia and takes no medications.  Vital signs are normal.  On physical examination, the patient is tall with long upper extremities and fingers.  The face appears narrow with down-slanted palpebral fissures, flattened malar bones, and a small jaw.  The lungs are clear on auscultation.  The abdomen is soft with no organomegaly. The patient is diagnosed with Marfan syndrome, and he is cooperative with his medical appointments. He is working as driver.

Patient description (patient's own words): I'm a 20-year-old guy, working as a driver and I went to the clinic for my routine checkup. I have myopia, so I wear glasses and I don't take any other medications. My vitals were normal. I also did a physical exam, and I was told that I have long legs, arms, and fingers. They also told me that my face is quite narrow, with down-slanted eyes and a small jaw. My lungs were fine and my tummy too. I have been diagnosed with Marfan syndrome and I haven't been skipping any medical appointments since.

Does the patient match the trial criteria? 0