araag2/NLI4PR huggingface dataset:
Clinical trial: Pilot Study: A Parent-Infant Fragile X Intervention (PIXI) (NCT03836300)

Eligibility criteria:
Inclusion Criteria:

          -  Infants identified with FXS prior to 2 months of age with parents/caregivers who speak
             English

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers

Subject must be at most 6 Months

Patient description (medical language): A 15-year-old boy with mild intellectual disability is brought to the office by his parents for a routine physical examination.  The boy is going to a school for students with learning disabilities.  The patient was adopted, and his immunizations are up to date.  Review of the patient's medical records is notable for cytogenetic studies that showed a small gap near the tip of the long arm of the X chromosome, which is consistent with fragile X syndrome, an X-linked disorder. The defect is an unstable expansion of trinucleotide repeats (CGG) in the fragile X mental retardation 1 (FMR1) gene, located on the long arm of the X chromosome. He is not using any medications and vital signs are within normal levels. His blood chemistry analysis as bellow:
Blood Chemistry Value      Normal Range     Patient Value
Glucose                    90-120 mg/dl     95 mg/dl
BUN (Blood Urea Nitrogen)  7-24 mg/dl       10 mg/dl
Creatinine                 0.7-1.4 mg/dl    0.8 mg/dl
Calcium                    8.5-10.5 mg/dl   9 mg/dl
Sodium                     134-143 mEq/L    135 mEq/L
Potassium                  3.5-4.5 mEq/L    3.7 mEq/L
Chloride                   95-108 mEq/L     98 mEq/L
CO2                        20-30 mEq/L      25 mEq/L
Blood pH                   7.38-7.42        7. 39

Patient description (patient's own words): My husband and I brought our 15-year-old son to the clinic for his routine exam. My son is going to school for special needs students. We adopted him a few years ago. His vaccinations are up to date. He already passed some chromosome testing and they found that he has a fragile X syndrome. The doctor told us that it comes from repeats in the fragile X chromosome. My son is not using any medication and his blood pressure temperature and breathing were normal during the exam. He also did a blood test. The results came back and showed that his blood sugar urea creatinine calcium sodium potassium chloride CO2 and blood pH were all within the normal range.

Does the patient match the trial criteria? 0
Clinical trial: Laparoscopic Inguinal Hernia Repair- Transabdominal Preperitoneal (TAPP) Versus Totally Extra Peritoneal (TEP) (NCT00687375)

Eligibility criteria:
Inclusion Criteria:

          -  All consecutive patients with uncomplicated symptomatic inguinal hernia attending the
             out patient department of surgery at AIIMS will be included in the study.

          -  The diagnosis of inguinal hernia will be made clinically.

        Exclusion Criteria:

          -  Co-morbid conditions making the patients unfit for general anaesthesia

          -  Complicated hernia.

          -  Uncorrectable coagulopathy

          -  Morbid obesity (Body Mass Index > 30)

          -  Suspected intra-abdominal or pelvic malignancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: A New Treatment for Zenker's Diverticulum-submucosal Tunneling Endoscopic Septum Division (NCT03125733)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of Zenker's diverticulum by symptoms, esophagram and/ or EGD

          -  Symptomatic score≥2 in any of the symptoms or ≥3 in total

          -  Patients or legal surrogates willing and competent to give informed consent and to
             comply with follow up visits and tests

        Exclusion Criteria:

          -  Patients with minimal symptoms (score ≤1 in all four symptoms and <3 in total)

          -  Presence of coagulopathy or pregnancy

          -  Patients who, in the investigator's opinion, are medically unstable or have a life
             expectancy of< 2 years, are unable to give informed consent or have poor compliance
             with follow-up, or whose risks of participating in the study outweigh the benefits
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? 1
Clinical trial: The Effect of the Nutraceutical "Hemofix" on the Coagulation System (NCT01651468)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy volunteers and volunteers with a mild bleeding disorder

        Exclusion Criteria:

          -  people with thrombophilic and cardiovascular complications,

          -  people who are treated with anti-coagulants,

          -  women taking birth control pills

          -  people with a history hypercoagulability
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? 1
Clinical trial: Adherence in Chronic Adrenal Insufficiency (NCT03399383)

Eligibility criteria:
Inclusion Criteria:

          -  Age > 18 years

          -  Patient's written informed consent

          -  Ability to comply with the protocol procedures

          -  Patients with chronic adrenal insufficiency under established stable replacement
             therapy

        Exclusion Criteria:

          -  Age < 18 years
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? 1
Clinical trial: Autologous Multipotent Mesenchymal Stromal Cells in the Treatment of Amyotrophic Lateral Sclerosis (NCT03828123)

Eligibility criteria:
Inclusion Criteria:

          1. established diagnosis of definite ALS according to El Escorial criteria

          2. riluzole naive or stable dose for at least 2 months,

          3. life expectancy more than 2 years

          4. patients able to provide written informed consent.

        Exclusion Criteria:

          1. FVC less than 70%

          2. in case of primary bulbar paralysis less than 15 points on Norris bulbar scale,

          3. less than 15 points on Norris spinal scale,

          4. pregnancy, breastfeeding

          5. coagulopathy,

          6. skin infection at the site of bone marrow aspiration or application of the cell
             product,

          7. gastrostomy,

          8. any significant medical condition that would compromise the safety of the patient
             (e.g. recent myocardial infarction, congestive heart failure, renal failure, liver
             failure, cancer, systemic infection, recurrent thromboembolic disease .....),

          9. alcohol or drug abuse

         10. cancer.

         11. women of childbearing potential not using effective contraception (established oral
             contraception, intrauterine device, ligation of the uterine tube) including proven
             contraceptive measures taken by their sexual partners

         12. fertile men not using proven contraceptive measures including effective contraception
             of their partner (established oral contraception, intrauterine device, ligation of the
             uterine tube)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? 1
Clinical trial: Interprofessional Dementia Care (NCT04741932)

Eligibility criteria:
Inclusion Criteria:

          -  70+ years

          -  PwD lives at home

          -  existing dementia diagnosis or screening result of DemTect <9

          -  caregiver: main caregiver of a PwD (Hauptversorgungsperson)

        Exclusion Criteria:

        - not able to provide written consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 70 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 1
Clinical trial: Cervical Mobility and Vestibular Rehabilitation (NCT02622516)

Eligibility criteria:
Inclusion Criteria:

          -  People from the age of majority (18 years) to 69 years, considered by the population
             division in youth, adults and older people to 69 years according to the World Health
             Organization (WHO) , of both genders, with commitment by diagnosed peripheral
             vestibular disorders clinically by a doctor, including the peripheral vestibular type
             Benign Paroxysmal Positional Vertigo (BPPV), with vestibular symptoms, with higher
             scores than or equal to a spot on the Visual Analogue Scale (VAS) Dizziness or higher
             rank than or equal to 16 points in the questionnaire dizziness Handicap Inventory
             (DHI).

        Exclusion Criteria:

          -  Elderly aged 70 or more, which have visual impairment and/or total hearing, orthopedic
             disorders that limit the realization of the proposed activities, nervous system
             injuries that cause damage engines and/or additional sensitive and diagnostics of
             Ménière's disease.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 72 Years

Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? 1
Clinical trial: Bilateral Essential Tremor Treatment With FUS (NCT04501484)

Eligibility criteria:
Inclusion Criteria:

          -  Patients must be ≥ 18 years

          -  The patient has a primary diagnosis of ET or ET plus confirmed by a movement disorder
             neurologist;

          -  The patient previously underwent a MRgFUS (> 6 months ago);

          -  The tremor on the untreated side negatively impacts the patients' quality of life;

          -  The patient wants treatment of the contralateral side.

        Exclusion Criteria:

          -  Clinically relevant gait and/or balance impairment (e.g. wide-based, more than 2
             falls/months, wheelchair, walker, cane use)

          -  Clinically relevant speech impairment (e.g. impairment of intelligibility)

          -  Inability to comply with the follow-up schedule;

          -  Refusal of the treating physician.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 1
Clinical trial: Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein (NCT00196001)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy males and females aged 6-60

        Exclusion Criteria:

          -  Known medical condition

          -  Use of inhaled, topical, or oral steroids

          -  Use of oral contraceptive pills or hormone replacement

          -  Menopause

          -  Pregnancy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 6 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? 0