araag2/NLI4PR huggingface dataset:
Clinical trial: Changes in Bleeding and Clotting During the Menstrual Cycle (NCT00480545)

Eligibility criteria:
Inclusion Criteria:

          -  Must be female

          -  Aged 18 to 50 years, with regular menstrual cycles.

          -  Healthy volunteers and women with von Willebrand's disorder are both being recruited.

        Exclusion Criteria:

          -  Pregnancy

          -  Use of hormonal therapy including birth control pills

          -  Use of hemostatic agents such as DDAVP or anti-platelet agents.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? 1
Clinical trial: Ultrasound Examination of Inguinal Lymph Node Used to Evaluate the Effect of Acupuncture on Knee Osteoarthritis (NCT04503941)

Eligibility criteria:
Inclusion Criteria:

          1. Patients who meet the western medicine diagnostic criteria of knee osteoarthritis;

          2. Aged between 50 and 75 years;

          3. Patients in line with the 0-III level of radiological classification for knee
             osteoarthritis degeneration;

          4. Patients who did not use glucocorticoid via oral administration or intramuscular,
             articular, or soft tissue injection four weeks before accepting the test agent;

          5. Normal line of force;

          6. Patients who signed the informed consent and ensured the compliance.

        Exclusion Criteria:

          1. Patients with long-term oral administration of agents for knee osteoarthritis, and
             still in the drug effect period, without elution;

          2. Patients with severe heart, brain, liver, kidney or lung dysfunction;

          3. Patients with other knee diseases found in arthroscopic surgery;

          4. Patients who have accepted other relevant treatments, which may affect the observation
             on the effects of this study;

          5. Patients with mental illness;

          6. Patients with coagulation dysfunction;

          7. Patients with articular surgical treatment;

          8. Patients with a history of abuse of opioid analgesics, sedative hypnotics or alcohol;

          9. Patients with poor compliance, who were unable to meet the requirements for follow-up.

         10. Pregnant and lactating women.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 0
Clinical trial: Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung Lining (NCT00242723)

Eligibility criteria:
-  INCLUSION CRITERIA:

        Patients with potentially malignant or suspicious lesions, or with biopsy proven lung
        cancers or esophageal cancers, malignant pleural mesotheliomas, mediastinal or chest wall
        neoplasms, thymoma/thymic carcinomas, or thoracic metastases from cancers of non-thoracic
        origin.

        Patients must have an ECOG performance score of 0-2.

        Patients must be 2 years of age or older. Note: Patients >= 2 and < 18 years of age may
        participate in research sample collection if the tissue acquisition is performed during a
        clinically indicated surgical procedure, and the sampling of tissue, blood and urine does
        not add risk to the clinically indicated procedures.

        Patients must be aware of the nature of his/her illness. The patient must be willing to
        undergo standard intervention that may include endoscopic biopsies of tumor and adjacent
        normal tissues, and to provide blood and urine samples to support ongoing laboratory
        research endeavors pertaining to the epigenetics of thoracic malignancies.

        Ability of subject, their parents/guardians or legally authorized representative (LAR) to
        understand and the willingness to sign a written informed consent document.

        EXCLUSION CRITERIA:

        None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.


Patient description (medical language): A 61-year-old man comes to the clinic due to nonproductive cough and progressive dyspnea.  The patient's medical conditions include hypertension, hypercholesteremia and peptic ulcer disease.  He smokes 2 packs of cigarettes daily for the past 30 years.  On examination, there are decreased breath sounds and percussive dullness at the base of the left lung.  Other vital signs are normal. Abdomen is soft without tenderness. CT scan shows a left-sided pleural effusion and nodular thickening of the pleura. The plural fluid was bloody on thoracentesis. Biopsy shows proliferation of epithelioid-type cells with very long microvilli.

Patient description (patient's own words): I am 61 and I had to go to the clinic because I couldn't stop coughing and I experienced some breath shortness. I suffer from hypertension and cholesterol and I also have a stomach ulcer. I should admit that I've been smoking 2 packs of cigarettes every day for the past 30 years. My doctor told me that my breath in my left lung sounds bad. But he told me that my blood pressure, heart rate, breathing rate and temperature are normal. My belly is also normal. However my X-Rays show some liquid on the left side and a mass where the liquid got hard. The scary thing is that the liquid was bloody when they got it out. They did a biopsy and it showed that I have an increase of epithelioid-type cells with very long microvilli.

Does the patient match the trial criteria? 1
Clinical trial: Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population (NCT02076672)

Eligibility criteria:
Inclusion Criteria:

          1. Asbestosis (defined as diffuse lung scarring based on increased profusion of
             interstitial fibrosis)

          2. Benign pleural disease (defined as thickening or fibrotic plaques on pleural surfaces
             of the lung bilaterally)

        Exclusion Criteria:

          1. Prior systemic chemotherapy, radiation therapy or both.

          2. A current or previous history of primary malignancy.

          3. Known allergy to artichoke.

          4. Known bile duct obstruction.

          5. Known pregnancy or lactating women.

          6. Known psychiatric illness/social situations that would limit study compliance.

          7. Receiving any other investigational agents.

          8. Inability to understand or unable to provide written informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? 1
Clinical trial: Epidemiological Investigation of COVID-19 in Laos Using a One-Health Approach in Human and Animals (NCT04716543)

Eligibility criteria:
All permanent residents of the household who meet the inclusion criteria of > 6 months old
        and living in their respective village for at least 6 months will be eligible to
        participate. All people from the anterior LACORIS study (2015-2019), will be invited to
        participate to the study.

        Over a year, active case finding for influenza-like illness (ILI) will be conducted among
        the cohort by staff at CILM. The suspected ILI cases will be first identified using the WHO
        clinical case definition of ILI and Covid 19 as either with:

        Acute onset of fever (> 37.5˚C axillary temperature or > 38˚C tympanic temperature) AND
        cough; OR Acute onset of ANY ONE OR MORE of the following signs or symptoms: Fever, cough,
        general weakness/fatigue, headache, myalgia, sore throat, coryza, dyspnoea, anosmia (loss
        of smell) or ageusia (loss of taste).

        with symptoms with onset within the last 10 days.

        Inclusion Criteria:

          -  Living in their respective village for 6 months or more.

          -  Physically reside in the village for more than 80% of the time during the duration of
             the study.

          -  Study subjects ≥ 6 months of age (no upper age limit).

          -  Consent form signed by patient, or if under 18 years of age or patients with learning
             difficulty or other vulnerability with impaired ability to decide on consent, signed
             by parent or guardian.

          -  Agrees to comply with study requirements.

        Exclusion Criteria:

          -  Study subjects under the age of 6 months.

          -  Study subjects or parents/guardians that do not accept participation.

          -  Study subjects or parents/guardians who refuse to sign informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: The KOMOtini BONE Study: Evaluation of the Osteogenic Potential of Sports (NCT03201302)

Eligibility criteria:
Inclusion criteria

          -  were 8-12 years and pre-pubertal

          -  were healthy and had no prior bone fractures or related surgical operation

          -  had not been involved in organized sport activities previously

          -  their body fat was <30%, e) had no history of growth irregularities

          -  were not receiving agents or drugs that affect bone tissue (e.g.
             Gonadotropin-Releasing Hormone (GnRH) agonists, antiresorptive, bisphosphonates, etc.)

        Exclusion Criteria:

          -  had prior bone fractures or related surgical operation

          -  had been involved in organized sport activities previously

          -  their body fat was >30%

          -  had history of growth irregularities

          -  were receiving agents or drugs that affect bone tissue (e.g. GnRH agonists,
             antiresorptive, bisphosphonates, etc.)

          -  missed more than 10% of training sessions
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 12 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? 0
Clinical trial: Comparison Between Rebamipide 2% Versus Autologous Serum (NCT03608761)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosis of Sjögren's syndrome

          -  dry eye symtoms

        Exclusion Criteria:

          -  history of ocular surface surgery less than one year or intraocular surgery less than
             three months in one or both eyes

          -  chronic use of drops in one of both eyes (e.g. : treatment for glaucoma)

          -  anterior segment disease (ocular scar pemphigoid, Stenvens Jhonson syndrome)

          -  presence of punctung plug (lacrimal plug) inserted in one or both lower lacrimal
             points

          -  systemic viral infections (Hepatitis B, Hepatitis C, HIV)
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1
Clinical trial: Study of FYU-981 in Hyperuricemic Outpatients With or Without Gout (Effect on Two Hyperuricemic Types) (NCT03375632)

Eligibility criteria:
Inclusion Criteria:

          -  Serum urate level:

               -  >= 7.0mg/dL in patients with gouty nodule or with history of gout, or >=8.0mg/dL
                  in patients with hypertension, diabetes or metabolic syndrome, or >= 9.0mg/dL

          -  Disease type in the classification of hyperuricemia: Uric acid-overproduction type or
             Uric acid-underexcretion type

          -  Outpatients

        Exclusion Criteria:

          -  Gouty arthritis within 14 days before randomized allocation
Male
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 0
Clinical trial: Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis (NCT03145922)

Eligibility criteria:
Inclusion Criteria:

          -  Between the ages of 18 and 85

          -  Diagnosis of sarcoidosis confirmed by either biopsy or by manifestations consistent
             with acute sarcoidosis in absence of other known diagnosis.

          -  Have a suspected diagnosis of sarcoidosis and is scheduled to undergo a biopsy
             procedure to confirm a diagnosis of sarcoidosis.

          -  Able to tolerate and willing to undergo study procedures

        Exclusion Criteria:

          -  Current cigarette smoking or smoking within six months prior to the study

          -  Currently or recently (<6months) on immunosuppressive therapy

          -  Pregnancy

          -  Patient inability to participate in the study, such as undergo venipuncture and or BAL
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 39-year-old woman comes to the clinic complaining of arthralgias and nodules on her legs.  She has no fever or other skin rashes. The prior medical condition is unremarkable, and she takes no medications.  On physical examination, there is moderate hepatomegaly. The lesions on her legs are tender and present predominantly on the anterior surface of the lower extremities. She doesn't smoke and drinks alcohol occasionally. The patient has 2 male sexual partners. Vital signs are normal. Chest x-ray demonstrates enlarged hilar lymph nodes, and laboratory testing reveals an elevated ACE level. Biopsy of the skin lesion shows noncaseating granulomas that stain negative for fungi & acid-fast bacilli.

Patient description (patient's own words): I'm just a 39-year-old young woman but lately I have noticed some underlying cysts on my legs and my joints were hurting so much. I don't have a fever. I don't have rashes. My medical history is totally clean and I don't take any medication. When I went to the clinic they did a physical examination where they found that my liver is enlarged. They also found that the lesions on my legs are kind of tender and they are located on the front side of my legs. I do not smoke and I drink alcohol occasionally. I have to male sexual partners. On the day of my visit my vitals were fine. I did an X-ray of my chest and I had swollen lymph nodes. I also has a blood test and it came back with a high ACE level. I also had a biopsy of my skin lesions that came back negative for fungi and AFB.

Does the patient match the trial criteria? 1