araag2/NLI4PR huggingface dataset:
Clinical trial: Traditional Chinese Medicine Formula Liu-Wei-Die-Huang-Wan in the Treatment of Osteoarthritis. (NCT04108832)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥20 years old

          -  Written informed consent obtained

          -  Been diagnosed with knee or hip osteoarthritis

          -  The physician interpretation of X-ray identification and joint space narrowing or bone
             spurs confirmed

          -  In randomized trials before entering if used steroids or non-steroid medications
             osteoarthritis stable doses required at least one week

          -  The WOMAC osteoarthritis index of the degree of pain assessment in the past two weeks
             at least> 4ppm pain

        Exclusion Criteria:

          -  Pregnant or breast-feeding women.

          -  Chemotherapy or radiation therapy in cancer patients
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 1
Clinical trial: Proton Pump Inhibitors in the Prevention of Iron Reaccumulation in Patient With Hereditary Hemochromatosis (NCT01524757)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with hereditary hemochromatosis (HH), homozygous for C282Y, currently treated
             with phlebotomy as maintenance therapy for at least 12 months with ≥ 3 phlebotomies
             per year.

          -  Ferritin level between 50-100 μg/L at start of the inclusion.

          -  Age: 18 years- 60 years and weight > 50 kg.

        Exclusion Criteria:

          -  Patients receiving other therapies such as chelating therapy or forced dietary
             regimen.

          -  Patients younger than 18 years.

          -  HH patients with excessive overweight (BMI > 35).

          -  Patients who are mentally incapacitated.

          -  Women being pregnant or expecting/ planning to become pregnant during the one year
             period of the study.

          -  Patients with a malignancy.

          -  Patients already on PPI treatment.

          -  Patients who experienced side effects of PPI's.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? 0
Clinical trial: Effects and Interactions of Liquorice and Grapefruit on Glucocorticoid Replacement Therapy in Addison's Disease (NCT01271296)

Eligibility criteria:
Inclusion Criteria:

          -  Verified diagnosis of adrenal insufficiency (Addison's disease)

          -  Stable cortisone acetate replacement therapy

          -  Written informed consent

        Exclusion Criteria:

          -  Malignant disease

          -  Pharmacological treatment with other glucocorticoids

          -  Pregnancy

          -  Current minor disease (ie the flu)

          -  Major disease or accident requiring hospitalization the last three months

          -  Use of grapefruit juice or liquorice the last two weeks before study start

          -  Blood pressure above 150mmHg systolic or 90 mmHg diastolic.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 33-year-old woman comes to clinic complaining of progressive fatigue, decreased appetite, and 11-lb weight loss in the past 2 months.  She uses levothyroxine because of the previously diagnosed Hashimoto disease. She has no other medical conditions and does not use tobacco, alcohol, or illicit drugs.  Physical examination shows a generalized increase in pigmentation of the skin.  Measurement of serum cortisol before and after administration of exogenous adrenocorticotropic hormone (ACTH) shows no difference in the levels. Stable glucocorticoid replacement therapy starts for her with the diagnosis for primary adrenal insufficiency (Addison disease)

Patient description (patient's own words): I went to the clinic because I was really suffering from fatigue and decreased appetite and I also lost 11 pounds over the past two months. I'm just 33 years old so that's not normal, especially for a woman. I take levothyroxine because I have been diagnosed with Hashimoto disease. I don't have any other medical condition, and I don't smoke I don't drink, and I don't do drugs. They also did my physical examination and they saw that I had an increase in pigmentation of my skin. They measured my cortisol level before and after giving me some ACTH hormone, and the results came back with no difference whatsoever. The doctor told me I have Addison disease and put me under glucocorticoid therapy.

Does the patient match the trial criteria? 1
Clinical trial: A Comparison of Orally Pilocarpine and Artificial Saliva in Xerostomy Treatment (NCT00438048)

Eligibility criteria:
Inclusion Criteria:

          -  Patiens over 18 years, with primary or secondary Sjogren's Syndrome and xerostomia.

        Exclusion Criteria:

          -  Patiens with cardiac, pulmonary, renal, gastric diseases,

          -  Patients with diabetes, glaucoma, Multipleesclerosis,

          -  Pregnant women.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 1
Clinical trial: Epi-GERD Study: Epidemiological Evaluation in Patients With Gastro-Esophageal Reflux Disease (GERD) (NCT04094402)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18 years

          -  Previous diagnosis of Gastroesophageal Reflux Disease (GERD)

          -  CURRENT treatment with a proton-pump inhibitor (PPI), OR NOT CURRENT treatment with
             some PPI but YES in the last year

        Exclusion Criteria:

          -  Refusal to participate in the study by the patient.

          -  Patients who, in the judgment of the Investigator, do not understand or are not
             willing to adequately answer to the questions.

          -  Mental or psychiatric illness that, in the judgment of the investigator, does not
             allow adequate information to be obtained.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 1
Clinical trial: The Impact of Gynecological Surgery on Ovarian Function in Women of Reproductive Age: Postoperative Changes of Serum Anti-Müllerian Hormone (AMH) (NCT00928044)

Eligibility criteria:
Inclusion Criteria:

          -  For both operation and control groups, women were eligible for inclusion if they had
             regular menstrual cycles and no history of pelvic surgery.

        Exclusion Criteria:

          -  No endocrine disorders (e.g. PCOS).

          -  Received any kind of medication that could affect the results within the preceding 6
             months.

          -  Any woman who had a suspected pathologic lesion in the ovary or menopausal symptoms.
Female
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 49 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 1
Clinical trial: Prophylaxis Versus on Demand Treatment for Children With Hemophilia A (NCT01810666)

Eligibility criteria:
Inclusion Criteria:

          -  Male, aged 2-16yrs

          -  Severe hemophilia A (<1% FVIII:C [Blood Clotting Factor VIII:C] )

          -  Minimum of at least 50 documented ED (exposure day) prior to enrolment

          -  No measurable inhibitor activity at baseline and history of FVIII inhibitor antibody
             formation

          -  Parents or legal guardians document, sign, and date informed consent

        Exclusion Criteria:

          -  Another bleeding disease that is different from hemophilia A

          -  Known hypersensitivity to the active substance, mouse or hamster protein

          -  Thrombocytopenia (platelet count <100 000/mm3) based on previous medical records
Male
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 16 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Velocimetric Study of Temporal Arteries in Patients With Horton Disease Using Scan-Doppler (NCT03360162)

Eligibility criteria:
Inclusion Criteria:

          -  patients with suspicious giant arteritis

        Exclusion Criteria:

          -  patients who have already been treated or diagnosed for giant arteritis
No condition on gender to be admitted to the trial.

Subject must be at least 55 Years old.


Patient description (medical language): A 61-year-old man comes to the emergency department complaining of an acute vision disturbance. He had an episode of vision disturbance in the right eye that occurred suddenly and resolved spontaneously in 15 minutes. He also has right jaw pain while chewing.  He also complains of fatigue and hip muscle aches over the last several months.  The patient has a history of mild hyperlipidemia that has been controlled by diet and lifestyle modifications.  On examination, his blood pressure is 130/70 mm Hg and pulse is 66/min.  Neurological examination is unremarkable.  Visual examination is also normal. ESR is 103 mm/h. Temporal artery biopsy shows multinuclear giant cells and internal elastic membrane fragmentation.

Patient description (patient's own words): I’m a 61-year-old man and I came to the ER because I had a sudden episode where I couldn’t see out of my right eye. It only lasted about 15 minutes and went away on its own but it really scared me. I’ve also been having pain in my right jaw when I chew. For the past few months I’ve felt really tired and noticed my hips ache a lot. I have a history of mild cholesterol issues but I’ve been managing that with my diet and lifestyle. When the doctors checked me my blood pressure and pulse were normal and my vision and neurological exams didn’t show anything wrong. However they ran some tests and said my ESR levels were very high and a biopsy of my temporal artery showed some inflammation and damage.

Does the patient match the trial criteria? 0
Clinical trial: Anti-Müllerian Hormone (AMH) Measured With Fully Automated Assay Versus AFC in the Prediction of Ovarian Response (NCT04168892)

Eligibility criteria:
Inclusion Criteria:

        BMI between 18 and 30 kg/m2, basal serum day 3 FSH ≤ 15 IU/l, normal regular menstrual
        cycles, ranging from 25 to 33 days in length, normal thyroid-stimulating hormone (TSH) and
        prolactin levels, normal uterine cavity as assessed by hysteroscopy or sonohysterography or
        three-dimensional ultrasound and presence of both ovaries.

        Exclusion Criteria:

        irregular menstrual cycles, severe endometriosis, defined as stage III-IV of the American
        Society for Reproductive Medicine (ASRM) revised classification, previous ovarian surgery,
        presence of ovarian cysts, polycystic ovary syndrome, use of hormonal contraception in the
        previous 3 months and use of gonadotrophins in the previous 3 months, any known metabolic
        or endocrinological disease
Female

Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 0
Clinical trial: Safety and Efficacy of Umbilical Cord Mesenchymal Stem Cell Therapy for Patients With Duchenne Muscular Dystrophy (NCT01610440)

Eligibility criteria:
Inclusion Criteria:

          -  Aged 5-12 years

          -  Clinical manifestation, enzymology, electromyogram, gene type confirmed the diagnose
             of Duchenne muscular dystrophy

          -  Sign the consent form and follow the clinic trail procedure

        Exclusion Criteria:

          -  Not Duchenne muscular dystrophy

          -  Any history of hypersensitivity to serum products,or other know drug and food allergy

          -  Combined Pneumonia or other Severe systemic bacteria infection

          -  HIV+, TPPA +， patients diagnosed as HBV or HCV

          -  Tumor Markers +

          -  Severe psychotic patients, cognitive dysfunction

          -  Coagulation disorders

          -  Uncontrolled hypertension after treatment，blood pressure≥180mmHg/110 mmHg

          -  Other severe systemic or organic disease

          -  Enrollment in other trials in the last 3 months

          -  Received any stem cell therapy in past 6 months

          -  Other criteria that investigator consider improper for inclusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 5 Years old.
Subject must be at most 12 Years

Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? 1