araag2/NLI4PR huggingface dataset:
Clinical trial: Dexamethasone Versus Placebo in Optimizing the Postoperative Period After Laparoscopic Inguinal Hernia Repair (NCT01170780)

Eligibility criteria:
Inclusion Criteria:

          -  patients planned for elective laparoscopic hernia repair (TAPP)

          -  Unilateral inguinal or femoral hernia

          -  ASA class I-II

          -  Read and speak Danish

        Exclusion Criteria:

          -  Acute hernia operation

          -  Operation for other hernias with mesh during the same procedure

          -  Endocrine disease (diabetes, adrenal insufficiency etc.)

          -  fever/infection within the first 10 days before operation

          -  Poor compliance

          -  No signed consent form

          -  Daily intake of opioids or anxiolytic drugs

          -  Manic episodes

          -  Use medicine against glaucoma

          -  Use thiazide or loop diuretics

          -  Vaccination within the last 14 days
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: COVID-19 Infection in Cancer Pantients (NCT04569292)

Eligibility criteria:
Inclusion Criteria:

          -  confirmation of COVID-19 in the laboratory (RT-PCR techniques);

          -  suspected cases of COVID-19; clinically diagnosed based on symptoms (fever> 37.5 °,
             decrease in oximeter saturation by at least 5%, cough, diarrhea, otitis, dysgeusia,
             myalgia, arthralgia, conjunctivitis and rhinorrhea) + close contact a COVID-19 subject
             positive;

          -  asymptomatic cases; diagnosed based on positive swab results but without symptoms even
             dead patients

        Exclusion Criteria:

        -
No condition on gender to be admitted to the trial.




Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: Safety, Tolerability and Pharmacokinetics of SAR113945 Following Intra-articular Administration in Patients With Knee Osteoarthritis (NCT01113333)

Eligibility criteria:
Inclusion criteria:

          -  Male patients or female patients of non child-bearing potential, aged at least 40
             years with primary knee osteoarthritis having:

               -  X-ray or Magnetic Resonance Imaging (MRI) evidence for Kellgren Lawrence Grades
                  II./III joint space narrowing and osteophyte formation,

               -  Western Ontario MacMaster (WOMAC) score ≦ 72,

               -  American College of Rheumatology (ACR) Clinical and Radiographic criteria for
                  osteoarthritis.

        Exclusion criteria:

          -  Any uncontrolled, chronic condition or laboratory finding which, in the opinion of the
             Principal Investigator, could potentially put the patient at increased risk.

          -  Secondary osteoarthritis.

          -  Moderate/severe renal impairment.

          -  Underlying hepatobiliary disease and/or elevated Alanine Aminotransferase (ALT) > 3
             Upper Limit of Normal range.

          -  Intra-articular injection within 3 months.

          -  Presence of local skin abnormality at the affected knee joint.

          -  Unable to be maintained for at least 2 weeks prior to entry into study on paracetamol
             or metamizole as analgesic.

          -  Any Investigational Product within 3 months.

          -  Any patient unlikely to comply with the requirements of the study.

        The above information is not intended to contain all considerations relevant to a patient's
        potential participation in a clinical trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Exploration of the Reward System by Functional MRI in Narco-cataplexy Patients With and Without REM Sleep Behavior Disorder (NCT03425214)

Eligibility criteria:
Inclusion Criteria:

          -  - Men or women, right handed, 18 to 80 years

          -  Patients with type 1 Narcolepsy according to the criteria of the International
             Classification of Sleep, 3rd version, 2014

          -  Acceptance of the protocol and signature of a written consent

          -  Social security affiliation

        Exclusion Criteria:

          -  Previous history of psychosis or psychiatric disease

          -  History of stroke or vascular lesion on MRI.

          -  Perceptual disorder (vision, hearing) may hinder the realization of the protocols,

          -  Dementia defined by a score across Montreal Cognitive Assessment (MoCA) <26/30.

          -  Major depressive state defined by a score scale Beck Depression Inventory (BDI)> 14

          -  Apathy defined by a score ≥ 14 on the Apathy Scale of Starkstein. Patients with a
             score ≥ this one will be excluded.

          -  Usual contraindications to MRI, knowing that no contrast agent injection is performed.

          -  Pregnant woman.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 25-year-old woman comes to the clinic with her roommate.  The roommate says that the patient has twice fallen asleep while they were talking.  The patient has regularly fallen asleep in the afternoon while reading or watching television but typically feels refreshed after a brief nap.  She also reveals that she sometimes hears a voice prior to falling asleep.  She also complains of some episodes of clumsiness that cause her to drop objects or fall. MSLT showed that the sleep latency was less than 8 min and that the patient enters rapid eye movement (REM) sleep almost immediately.

Patient description (patient's own words): I brought my roommate to the clinic because she kept falling asleep when we were having a conversation. We're both 25 and usually healthy girls. She usually takes a nap in the afternoon while reading or watching TV, but usually, she is quite energetic afterward. She told me that she sometimes hears a voice before falling asleep. How weird! And sometimes she's the clumsiest! She keeps dropping all her stuff. The doctor did a sleeping test and she found out that it takes her less than 8 min to fall asleep.

Does the patient match the trial criteria? 1
Clinical trial: Turkish Acquired Haemophilia Registry (NCT01403740)

Eligibility criteria:
Inclusion Criteria:

          -  Acquired haemophilia diagnosis, written consent

        Exclusion Criteria:

          -  Being unable to give written consent
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Suppression of Daytime and Nighttime Luteinizing Hormone Frequency by Progesterone (NCT01428089)

Eligibility criteria:
Inclusion Criteria:

          -  Female volunteers in early to mid-puberty (i.e., late Tanner I [estradiol level > 20
             pg/mL], Tanner II, or Tanner III)

          -  Premenarcheal

        Exclusion Criteria:

          -  Pregnancy

          -  Inability to comprehend what will be done during the study or why it will be done

          -  Hemoglobin less than 12 g/dl and hematocrit less than 36%

          -  Persistently abnormal sodium, potassium, or bicarbonate (i.e., confirmed on repeat)

          -  Persistently elevated creatinine, hepatic transaminases, or alkaline phosphatase
             (i.e., confirmed on repeat)

          -  Total bilirubin > 1.5 times upper limit of normal (i.e., confirmed on repeat)

          -  Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected
             congestive heart failure; asthma requiring intermittent systemic corticosteroids;
             etc.)

          -  Untreated hypo- or hyperthyroidism, reflected by persistently abnormal
             thyroid-stimulating hormone (TSH) values

          -  Total testosterone > 200 ng/dl

          -  Basal (follicular) 17-hydroxyprogesterone > 200 ng/ml (in girls without a previous
             diagnosis of congenital adrenal hyperplasia)

          -  Dehydroepiandrosterone sulfate (DHEA-S) > 800 mcg/dl

          -  Elevation of prolactin > 2 times upper limit of normal

          -  Weight less than 26 kg.
Female
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 14 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? 0
Clinical trial: Evaluation of Two Types of PRP in Knee Osteoarthritis (NCT02923310)

Eligibility criteria:
Inclusion Criteria:

        Patients with Osteoarthrits

        Exclusion Criteria:

          -  diabetes, rheumatoid arthritis, axial deviation (varus> 10 degrees valgus> 10
             degrees), blood disorders (coagulopathy and platelet changes), cardiovascular
             diseases, infections, immunosuppression, patients on anticoagulant therapy or
             antiplatelet use of nonsteroidal anti-inflammatory 5 days before blood collection,
             patients with hemoglobin concentrations <11 and platelet count <150,000 mm³.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? 1
Clinical trial: Study Evaluating the Safety and Efficacy of Autologous Non-Hematopoietic Peripheral Blood Stem Cells in COVID-19 (NCT04473170)

Eligibility criteria:
Inclusion Criteria:

          -  RT-PCR Laboratory confirmation of COVID-19.

          -  Male or female aged ≥ 18 years.

          -  Interstitial lung change ≥ 3 judged by "Lungs Lobar based scoring" according to
             computed tomography (CT) scans.

          -  Hospitalized and symptomatic patients, referring one or more of the following symptoms
             (fever, cough, or shortness of breath), in association with (at least one): tiredness,
             runny nose, headache, sore throat, chills, muscle pain, or new loss of taste or
             smell).

          -  Ability to comply with test requirements and peripheral blood stem cells collection.

          -  The patient or legal representative agrees to participate in the study, and signs the
             SENTAD-COVID Study informed consent form.

        Exclusion Criteria:

          -  Pediatric patients (aged < 18 years).

          -  Diagnosis of any kind of shock.

          -  Organ transplants in the past 3 months.

          -  Patients receiving immunosuppressive therapy.

          -  Diagnostic of Hepatitis B Virus (HBV) infection.

          -  Diagnostic of Human Immunodeficiency Virus (HIV) infection or Acquired
             Immunodeficiency Syndrome (AIDS).

          -  Current diagnosis of cancer.

          -  History of malignancies in the past 5 years.

          -  Pregnant or lactating women.

          -  Have participated in other clinical trials in the past 3 months.

          -  Inability to comply with test requirements and peripheral blood stem cells collection.

          -  Inability to provide informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 0
Clinical trial: Validation Study of Physical Measurement of Tophi (NCT00175006)

Eligibility criteria:
Inclusion Criteria:

          -  Must have at least 1 palpable gouty tophus nodule in the foot/ankle, hand/wrist, or
             elbow, confirmed as gouty by prior diagnosis according to ACR criteria.

          -  The tophus must be solid, round, non-tender, intact, and larger than 10mm in both
             length and width.

          -  Joints nearest and immediately adjacent to the selected tophus must not be acutely
             inflamed.

          -  Must be on stable treatment for gout with no medication changes in the past 30 days.

        Exclusion Criteria:

          -  Must be able to return to the clinical site within 10 days.

          -  Must not have allergy to ink.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 85 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 0
Clinical trial: Autologous Human Adipose-Derived Mesenchymal Stem Cells in Alzheimer's Disease (NCT04855955)

Eligibility criteria:
Inclusion Criteria:

          -  The patient is diagnosed with later stage of Alzheimer Disease with sever cognitive
             disability.

          -  All current anti-Alzheimer medicines cannot prevent disease progression and the
             patient's mental and physical ability persistently declined

          -  Patient's legal guardian and caregiver must voluntarily sign an approved written
             consent form after ample explanation of the proposed therapy.

        Exclusion Criteria:

          -  Current diagnosis of malignancy

          -  Renal/liver dysfunction: Exceed two times as normal subject

          -  Pregnant or nursing

          -  Received other trial drugs within 30 days after participation of this study

          -  Experienced major surgery or trauma in the last 14 days
No condition on gender to be admitted to the trial.




Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 1