araag2/NLI4PR huggingface dataset:
Clinical trial: Whey Protein on Posprandial Glucose, Insulin GLP-1, GIP and DPP4 in Type 2 Diabetes (NCT01571622)

Eligibility criteria:
Inclusion Criteria:

          1. Type 2 diabetic patients

          2. Duration of diabetes: 1-10 years

          3. Subjects ≥ 40 and ≤70 years of age

          4. Metformin therapy and all oral antidiabetic medication will be allowed

          5. Overweight or obese (BMI: 25 to 35 kg/m2)

          6. Normal liver and kidney function

          7. Normal thyroid function

          8. Read and understood the informed consent form and signed it voluntarily

        Exclusion Criteria:

          1. Liver, heart, kidney, lung, infectious, neurological, psychiatric, immunological or
             neoplastic diseases.

          2. Type 1 or insulin treated diabetes.

          3. Pregnancy or lactation

          4. Illicit drug abuse or alcoholism

          5. Subject treated with insulin or treatment with degradation-resistant GLP-1R agonists
             (Exendin-4) or similar and DPP4 inhibitors (Januvia)

          6. Subjects taking anoretic drugs

          7. Subjects on steroid treatment

          8. Subjects known by the principal investigator to be unable to cooperate for any reason.

          9. Known hypersensitivity to milk components

         10. Subjects after bariatric surgery.

             -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? 1
Clinical trial: Memory and Picture Viewing Study (NCT00736203)

Eligibility criteria:
Inclusion Criteria:

          -  generally healthy

          -  right-handed non-smokers

          -  between the ages of 18-55

          -  an expired CO concentration of 5 ppm or less; or a negative urine cotinine test of 100
             ng/mL or less (to confirm a non-smoker)

          -  having smoked < 50 cigarettes in their lifetime

        Exclusion Criteria:

          -  inability to attend all sessions

          -  significant health problems (hypertension, emphysema, seizure disorder, history of
             significant heart problems)

          -  use of psychoactive medications

          -  use of any tobacco or nicotine containing products

          -  current alcohol or drug abuse

          -  use of illegal drugs as measure by a urine drug screen

          -  presence of conditions that would make MRI unsafe (pacemaker, metallic implants
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? 0
Clinical trial: Platelet Rich Plasma Injection for Knee Osteoarthritis (NCT04454164)

Eligibility criteria:
Inclusion Criteria:

          -  stage 1-2-3 symptomatic OA patients according to Kellgren / Lawrence staging

          -  mean VAS pain score of >4 of 10 (worst possible pain) over the course of 7 days during
             the previous month

        Exclusion Criteria:

          -  OA secondary to joint inflammatory diseases,

          -  generalized OA,

          -  metabolic diseases of the bone,

          -  coexisting backache,

          -  the presence of hematological disease (coagulopathy),

          -  bilateral symptomatic lesions and advanced stages (grade 4) of OA,

          -  patients who had received intra-articular injections within 3 months or arthroscopic
             lavage in the previous 1 year,

          -  patients who were receiving immunosuppressive,

          -  patients with current use of anticoagulant medications,

          -  NSAIDs used in the 5 days before blood donation,

          -  major axis deviation (more than 15 degree of varus or more than 5 degree of valgus
             deviation),

          -  patients with a hemoglobin level less than 11.5 g/dL,

          -  platelets level less than 100,000/μL,

          -  associated comorbidities, infection, tumor, crystal arthropathies, anemia, tense joint
             effusion and pregnancy or possibility of pregnancy.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Bronchodilators for Wheeze in Young Children Presenting to Primary Care: a Randomised, Placebo-controlled, Multicentre, Parallel Group Trial (NCT04584034)

Eligibility criteria:
Inclusion Criteria:

          -  Presenting to their primary care physician because of wheezing as confirmed by
             clinical examination (chest auscultation)

          -  A baseline score of 7 or higher on a parent-reported respiratory symptom score

        Exclusion Criteria:

          -  Prematurity (<37 weeks)

          -  Major congenital malformations

          -  Pre-existing pulmonary disease as diagnosed by a paediatrician

          -  Continuous use of inhalation medication

          -  Physician visit because of wheezing in previous two weeks

          -  Use of inhalation medication in the previous two weeks

          -  Wheezing as a result of upper airway obstruction (i.e. laryngitis
             subglottica/pseudocroup)

          -  Severe illness requiring inhalation medication, prescription of antibiotics, or
             hospital referral during the consultation of inclusion
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 24 Months

Patient description (medical language): A 7-year-old girl is brought to the emergency department by her parents for generalized rash.  The mother reports that she was playing outside wearing a skirt and felt a sharp pain in her arm while seating on a mat, plying with her doll.  Her mother suspects that something had stung her.   The patient's blood pressure is 75/55 mm Hg and her heart rate is 122/min.  Physical examination shows erythematous, raised plaques over the trunk, extremities, and face.  Lung auscultation reveals bilateral expiratory wheezes.

Patient description (patient's own words): I just brought my seven-year-old girl to the ER because she just developed a terrible rash. My little girl was playing outside and she was wearing a lovely little skirt and all of a sudden. She felt like a really sharp pain in her arm. She was sitting on a mat playing with her doll. I think that something stung her. They took her blood pressure, and it turned out to be 75 out of 55. Her heart rate was 122. Then they did a physical examination, and it showed rashes all around her trunk, extremities, and face. Her breath test revealed some high-pitched breathing.

Does the patient match the trial criteria? 0
Clinical trial: Effect of Exercise in Pediatric Hemophilia (NCT04754997)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed with hemophilia (Hemophilia A) by a hematologist

          -  Hemophilia is moderate or severe, without spontaneous bleeding complaints

          -  Having a history of bleeding in the knee joint

          -  Not doing any regular exercise

          -  Willing to continue working and will not start other treatment during the study

          -  Patients whose parents were informed about the study and whose consent form was
             obtained

        Exclusion Criteria:

          -  Those who have undergone another surgery (joint debridement, fracture, knee
             replacement) that will affect lower extremity function

          -  Those with neurological disease or any sensory loss or peripheral nerve injury that
             may affect functional performance and balance
Male
No healthy subjects accepted to join the trial.
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Evaluate Efficacy and Safety of ADVATE in the Standard Prophylaxis Treatment of Severe or Moderately Severe Hemophilia A (NCT02282410)

Eligibility criteria:
Inclusion Criteria:

          1. Subject has hemophilia A with FVIII≤2 %.

          2. Previously treated patients (PTPs).

          3. Age from 2 to 18 years.

        Exclusion Criteria:

          1. Subject has known hypersensitivity to the active substance or any of the excipients.

          2. Subject has known allergic reaction to mouse or hamster proteins.

          3. Subject has participated in another clinical study involving an investigational
             product (IP) or device within 30 days prior to study enrollment or is scheduled to
             participate in another clinical study involving another FVIII concentrate or device
             during the course of this study.

          4. Subject is planned, or likely to have surgery during the study period.

          5. Subject has end-stage renal failure or evidence of a severe or uncontrolled systemic
             disease as judged by the investigator.

          6. Subject has full-blown Acquired Immuno Deficiency Syndrome (AIDS),determined by
             cluster differentiation antigen 4+ (CD4+) and clinical presentation.

          7. Subject has active hepatic disease (alanine aminotransferase (ALT) and aspartate
             aminotransferase (AST) levels > 5 times the upper limit of normal).

          8. Subject has clinical or laboratory evidence of severe liver impairment including (but
             not limited to) a recent and persistent international normalized ratio (INR)> 1.4,
             and/or the presence of splenomegaly and/or significant spider angioma on physical
             exam, and/or a history of esophageal hemorrhage or documented esophageal varices.

          9. The subject in the opinion of the investigator is unable or unwilling to comply with
             study protocol

         10. Subject is a family member of the investigator or site staff
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Telerehabilitation Gait Modification (NCT04683913)

Eligibility criteria:
Inclusion Criteria:

          -  50 years of age or older

          -  Exhibit signs of tibiofemoral osteoarthritis based on a score of ≥2 on the Kellgren
             and Lawrence grading scale predominantly in the medial compartment.

          -  Self-reported knee pain ≥ 3 / 10 on a numerical rating scale of pain (NRS; 0 = "no
             pain" and 10 = "worst pain imaginable") during most days of the previous month

          -  Comfortable walking intermittently for 30 minutes

          -  Fit into the available sizes of sensor shoes (between US women's 5 to men's 13)

          -  Exhibits ≥2% reduction in knee adduction moment impulse at 10 degrees of change in
             toe-in or toe-out during the screening appointment.

        Exclusion Criteria:

          -  Any knee surgery or intraarticular injections within the past 6 months

          -  A history of joint replacement surgery or high tibial osteotomy

          -  Current or recent (within 6 weeks) corticosteroid injections

          -  Use of a gait aid

          -  Currently on a wait list for joint replacement surgery or high tibial osteotomy

          -  Any inflammatory arthritic condition

          -  Any other conditions that may affect normal gait or participation in an aerobic
             exercise program

          -  Cannot attend all required appointments
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 0
Clinical trial: Examining the Impact of Tampon Use on the Vaginal Microbiota (NCT03346759)

Eligibility criteria:
Inclusion Criteria:

          -  regular menstrual cycles lasting 21-35 days

          -  menses lasting for at least 4 days

          -  current tampon user

          -  good self-reported general health

          -  good self-reported vaginal health

        Exclusion Criteria:

          -  currently pregnant

          -  planning to become pregnant in 4 months following enrollment

          -  difficulty using tampons

          -  current toxic shock syndrome

          -  history of toxic shock syndrome

          -  current sexually transmitted infection

          -  current urinary tract infection

          -  currently using antibiotics

          -  antibiotic use in 4 weeks prior to enrollment

          -  current antifungal use

          -  antifungal use in 4 weeks prior to enrollment

          -  autoimmune condition
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium (NCT02710981)

Eligibility criteria:
Inclusion Criteria:

          -  Women with clomiphene citrate failure (defined as at least prior 5 ovulatory cycles
             with clomiphene citrate, with no conception),

          -  persistently thin endometrium (less than 8 mm in at least 3 cycles).

          -  normal baseline FSH, LH, and free testosterone levels, patent tubes on
             hysterosalpingography, and normal male semen analysis

        Exclusion Criteria:

          -  Women with major medical problems,

          -  male factor infertility,

          -  endocrine abnormalities such as hyperprolactinemia or abnormal thyroid functions,

          -  prior ovarian or adnexal surgery, or organic pelvic pathology
Female
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0