araag2/NLI4PR huggingface dataset:
Clinical trial: Cryoneurolysis for the Management of Chronic Pain in Patients With Knee Osteoarthritis (NCT03774121)

Eligibility criteria:
Inclusion Criteria:

          -  Referred to GLA:D by a physician.

          -  Age ≥ 18y

          -  Chronic knee pain for a minimum duration of 6 months.

          -  Pain intensity ≥ 40mm on a 100mm visual analogue scale (VAS).

          -  Radiographic confirmation of osteoarthritis; Grade 2-4 changes according to the
             Kellgren Lawrence classification system

          -  A decrease of ≥ 50 % in VAS scores with diagnostic genicular nerve block.

          -  Written and oral understanding of Danish.

        Exclusion Criteria:

          -  History of systemic inflammatory conditions such as rheumatoid arthritis.

          -  Previous recipient of cryoneurolysis for the knee.

          -  Use of hyaluronic acid within the previous 30 days.

          -  Injection of corticosteroid within the previous 3 months.

          -  Clinical significant structural abnormities affecting locomotion and knee function
             aside from osteoarthritis and which might cause chronic knee pain.

          -  Body mass index ≥ 18 and ≤ 40 kg/m

          -  In treatment for other pain conditions.

          -  Pregnancy

          -  Coagulopathy

          -  Uncontrolled serious disease (cancer, diabetes, etc.)

          -  Disease associated with reactions to cold, such as cryoglobulinemia, cold urticarial
             and Renaud's syndrome.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: The Effect of Dairy on Bone Mass and Body Composition in 4th-8th Grade Boys and Girls (NCT00635583)

Eligibility criteria:
Inclusion Criteria:

          -  Males and females in 4th-8th grade

          -  Generally healthy

          -  BMI percentile 5-70% for age or >85% for age

          -  Baseline calcium intake less than or equal to 800mg/d

        Exclusion Criteria:

          -  History of any illness known to affect bone mass accrual (diabetes, inflammatory bowel
             disease, childhood malignancy).

          -  A broken bone in the last six months.

          -  Consume more than 800 mg Calcium/d.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 9 Years old.
Subject must be at most 14 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 0
Clinical trial: Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh (NCT01830452)

Eligibility criteria:
Inclusion Criteria:

          -  Primary unilateral inguinal hernia

          -  Capacitated male person

          -  Age ≥ 18 years

        Exclusion Criteria:

          -  Concurrent femoral hernia

          -  Incarcerated or strangulated inguinal hernia

          -  ASA 4 or ASA 5

          -  Impaired adequate follow up

          -  Participation in another trial
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: Premedication With Simethicone or Simethicone Plus N-acetylcysteine in Improving Visibility During Upper Endoscopy (NCT01653171)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnostic upper endoscopy performed for medical indications

        Exclusion Criteria:

          -  Upper gastrointestinal surgery

          -  Gastric Cancer

          -  Deep sedation with propofol

          -  Indication of therapeutic endoscopy

          -  Emergency endoscopy

          -  Patients with a history of

               -  Upper gastrointestinal bleeding

               -  Caustic ingestion

               -  Pregnancy

               -  Diabetes mellitus

               -  Asthma

               -  Allergic reactions to medication
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? 0
Clinical trial: Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention (NCT01192204)

Eligibility criteria:
Inclusion Criteria:

          1. Ages: 21 to 80

          2. Microscopically confirmed premalignant oral epithelial disease

          3. No previous history of cancer (with the exception of basal cell carcinoma of the skin)

          4. Tobacco free for at least six weeks prior to entrance in the trial and remain
             tobacco-free for the three month duration of the study

          5. Availability for necessary study follow-up evaluations (every 10 to 14 days during the
             trial)

          6. Capable of providing informed consent.

        Exclusion Criteria:

          1. Previous history of cancer (with the exception of basal cell carcinoma of the skin)

          2. Current use of tobacco products or refusal to remain tobacco-free for the three month
             duration of the study

          3. Lack of microscopically confirmed premalignant oral epithelial changes

          4. Microscopic diagnosis of oral squamous cell carcinoma

          5. Previous history of radiation therapy on same side of the head and neck region

          6. History of allergy to any kind of berry

          7. Women who are determined to be pregnant or plan to be pregnant during the trial

          8. Women who are nursing.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 21 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? 0
Clinical trial: Dissemination of the Cardiovascular Risk Service (NCT03660631)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical Staff Subjects:

               -  Must be a current clinic or pharmacy service employee who works as a provider,
                  pharmacist, nurse, clerk or administrator

          -  Patient Subjects:

               -  English or Spanish speaking

               -  Seen in the clinic at least once in the previous 12 months

               -  Currently has one of the following diseases:

                    1. Diabetes with HA1c 9.0% or greater and/or

                    2. Hypertension (uncomplicated) with systolic blood pressure 150 mm Hg or
                       greater

          -  Informal Caregiver Subjects:

               -  Person identified by the patient subject who assists the patient subject with
                  activities of daily living or other aspects of the patient subject's healthcare

        Exclusion Criteria:

          -  Study wide exclusions:

               -  Inability to give consent

               -  Nursing home residence

               -  No telephone

          -  Additional patient subject exclusions:

               -  Cancer with a life expectancy less than 24 months

               -  Pregnancy

               -  Diagnosis of dementia

               -  Plans to terminate care from the clinic within 24 months
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 67-year-old woman comes to the clinic due to recent episode of choking, dysphagia, and cough.  Her other medical problems include hypertension, dyslipidemia, and osteoarthritis.  She does not smoke or use alcohol. She lives with her husband and she is able to do her own daily activities. She used to teach elementary school. Blood pressure is 135/80 mm Hg.  The patient's breath smells bad. Other physical examinations are normal.  A barium swallow study reveals an abnormality in the upper esophagus with an outpouching at the junction of the lower part of the throat and the upper portion of the esophagus.

Patient description (patient's own words): I'm a 67-year-old lady, and I went to the clinic due to nonstop choking, difficulty swallowing, and coughing. I also suffer from hypertension, cholesterol, and osteoarthritis. I do not smoke or drink alcohol. I live with my husband, and we are independent retired elementary school teachers. During the exam, my blood pressure was 135/80 mm Hg. The doctor told me I had a smelly breath. How embarrassing! The rest of my physical exam was normal. I did a barium swallow test, which is an X-ray of my throat, which revealed a problem in the upper part of my esophagus, where there's a small pouch or bulge at the spot where my throat meets the esophagus.

Does the patient match the trial criteria? 0
Clinical trial: Evaluation Of Acceptability And Satisfaction Of Hemophilia Patients Treated With FusENGO (NCT01959919)

Eligibility criteria:
Inclusion Criteria:

          -  Male adults (aged 18 to 65 years) with Haemophilia A (all severity levels) who
             currently use FVIII treatment either prophylactically or on-demand using traditional
             factor VIII delivery mechanisms.

          -  Patients advised for any reason by their physician to switch to a new factor VIII
             delivery device, namely FuseNGO, before receiving any details about this study or
             Patients who requested to be treated with a new factor VIII delivery device namely
             FuseNGO, before receiving any details about this study.

        Exclusion Criteria:

          -  Patients not previously recommended by their physician to switch to this new factor
             VIII delivery system or Patients who did not previously ask their physician to be
             switched to this new factor VIII delivery system.

          -  Patients for which it is anticipated that 10 infusions will not occur in the 12 months
             following their inclusion in the study.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1
Clinical trial: Safety and Efficacy of Oxymetazoline HCl Cream 1.0% in Patients With Persistent Erythema Associated With Rosacea (NCT02132117)

Eligibility criteria:
Inclusion Criteria:

        -Moderate to severe persistent facial erythema associated with rosacea.

        Exclusion Criteria:

          -  Greater than 3 inflammatory lesions on the face

          -  Current treatment with monoamine oxidase (MAO) inhibitors

          -  Raynaud's syndrome, narrow angle glaucoma, orthostatic hypotension, scleroderma or
             Sjogren's syndrome.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? 1
Clinical trial: Memory and Insulin in Early Alzheimer's Disease (NCT00581867)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with Early Alzheimer's disease

        Exclusion Criteria:

          -  Patients with Late Alzheimer's disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 0
Clinical trial: Pharmacokinetics of Fentanyl Following Intravenous and Oral Routes of Administration in Healthy Volunteers (NCT00714558)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy, non smoker, men and nonpregnant nonlactating women

          -  Weighing a minimum of 60 kg and were within 15% of ideal weight for height as
             described in the Metropolitan Life Insurance Height and Weight Standards

          -  Who did not have a history or show presence of drug or alcohol dependence or abuse

          -  And who had, after sitting for 5 minutes, blood pressure between the ranges of 100 to
             150 mm Hg systolic and 50 to 90 mm Hg diastolic. Any decrease in systolic blood
             pressure after standing for 2 minutes had to be less than or equal to 20 mm Hg

        Exclusion Criteria:

          -  History of chronic obstructive pulmonary disease or any other lung disease, such as
             asthma, that would cause carbon dioxide retention

          -  Known allergy or hypersensitivity to fentanyl or other opioids, naltrexone or naloxone

          -  Usage of prescription medication (except for birth control medications, sex-hormone
             replacement or vitamins) within 14 days before Day 1, monoamine oxide inhibitors
             within 21 days prior to Day 1, over-the-counter medication (except for vitamin
             supplements or acetaminophen less than 2 gm/day) or herbal medication within 3 days
             prior to Day 1, alcohol, grapefruit juice, or caffeine within 48 hours before dosing

          -  Consumption of more than 450 mg of caffeine per day (eg, approximately 5 cups of tea,
             3 cups of regular coffee, or 8 cans of cola)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0