araag2/NLI4PR huggingface dataset:
Clinical trial: Behavior, Environment And Treatments for Covid-19 (NCT04321811)

Eligibility criteria:
Inclusion Criteria:

          -  People who are feeling sick and have tested positive for COVID-19

          -  People who are feeling sick but have not tested positive for COVID-19

          -  People who are not feeling sick but want to participate

        Exclusion Criteria:

        • People who are unwilling or unable to provide informed consent
No condition on gender to be admitted to the trial.

Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: Efficacy and Safety of a Single Dose of Canakinumab (ACZ885) in Hospitalized Patients With Acute Gout (NCT00663169)

Eligibility criteria:
Inclusion Criteria:

          -  score over 50 on the 0-100 VAS pain scale

          -  acute, confirmed gout flare for no longer than 3 days

        Exclusion Criteria:

          -  Treatment with biological anti-tumor necrosis factor (anti-TNF) within the past 3
             months

          -  Anti-inflammatory medication for the treatment of acute gout within the previous 24
             hours

          -  Pregnant or breastfeeding women

          -  Major surgery with high infection risk

          -  History of severe allergy to food or drugs

          -  History or risk of tuberculosis

          -  Active infection

        Other protocol-defined inclusion/exclusion criteria may apply
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 1
Clinical trial: COVID-19 Lessons Learned: the Outcome of TOMEKA® Project is to Teach (NCT04424940)

Eligibility criteria:
Inclusion Criteria:

          -  Fulfill Inclusion criteria and accept

          -  COVID-19 patients confirmed

          -  be regular on appointments

        Exclusion Criteria:

          -  COVID-19 suspected clinically

          -  Children

          -  refuse to participate
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 75 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? 1
Clinical trial: Impact of Menstrual Cycle on Antiretroviral Pharmacokinetics in Healthy Women (NCT00869960)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy, HIV negative, nonsmoking females between 21 and 40 years of age.

          -  Subjects must be within 20% of their ideal body weight and have a regular menstrual
             cycle, defined as at least 10 cycles per year occurring approximately every 28 ± 4
             days and cycle length varying by not more than 7 days.

          -  Subjects must be willing and able to provide written informed consent.

          -  Subjects cannot be breast feeding, pregnant or be taking hormonal contraception within
             3 months prior to study enrollment. However, they must agree to use an effective
             non-hormonal method of contraception during the study.

        Exclusion Criteria:

          -  Subjects receiving prescription or over-the-counter products which may interact with
             the study medication will be excluded from the study.

          -  Subjects with a Grade 3 or higher laboratory liver, renal or hematology abnormality as
             specified below in accordance with the DAIDS Table for Grading the Severity of Adult
             and Pediatric Adverse Events (DAIDS AE Grading Table) Version 1.0, Dec 2004, will be
             excluded.
Female
Accepts Healthy Volunteers
Subject must be at least 21 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 0
Clinical trial: New Approach for Treatment of Behavioral Disorders in Alzheimer's Disease (Alzheimer's Behavioral and Cognitive Disorders) (NCT02462291)

Eligibility criteria:
Inclusion Criteria:

          -  Person with Alzheimer's disease.

        Exclusion Criteria:

          -  Bedridden patients.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 65 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? 1
Clinical trial: Gynecomastia Extension Study (NCT00637182)

Eligibility criteria:
Inclusion Criteria:

          -  Subjects must have entered Trial 1033US/0006 and completed 6 months of treatment and
             one month of follow-up.

          -  Subjects must have gynecomastia, with one breast measuring at least 3 cm in diameter.

        Exclusion Criteria:

          -  Subjects who have been given medications known to cause gynecomastia within the
             previous 3 months
Male
No healthy subjects accepted to join the trial.
Subject must be at least 11 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 24-year-old man comes to the office complaining of infertility.  He and his wife have been trying to conceive for the last 18 months.  Medical records of his wife showed no abnormalities.  The patient doesn't smoke and takes no medications.  Height is 185 cm and weight is 77 kg.  Heart and lung sounds are normal.  There is bilateral gynecomastia and bilateral descended firm testes.  The lower extremities appear abnormally long. His karyotype evaluation shows 47, XXY consistent with Klinefelter syndrome.

Patient description (patient's own words): I'm only a 24 year old man but I’m already struggling with infertility. I went to a clinic with my wife the other day because we've been trying to have a baby for at least 18 months. The medical records of my wife are totally normal. For me I don't smoke or take any medication. I'm 185 cm and 77 kg. Everything was normal when the doctor inspected my lungs and my heart. The doctor said that I have enlarged breasts for a man. My testicles seem normal. The doctor noticed that my legs were abnormally long compared to the rest of my body. I also had a karyotype evaluation which led the doctor to diagnose me with Klinefelter syndrome.

Does the patient match the trial criteria? 0
Clinical trial: Relationship Between Pleural Elastance and Effectiveness of Pleurodesis on Recurrent Malignant Pleural Effusion (NCT01819363)

Eligibility criteria:
Inclusion Criteria:

          -  Malignant pleural effusion diagnosed by pleural fluid cytology and / or pleural
             biopsy;

          -  Recurrent pleural effusion (new accumulation of fluid after puncture) and symptoms
             (dyspnea and / or chest pain);

          -  Complete lung expansion (> 90%) after puncture emptying confirmed by chest
             radiography;

          -  Karnofsky index (KPS - Karnofsky Performance Status) > 30;

          -  Agreed to participate in the study and sign an informed consent.

        Exclusion Criteria:

          -  Thrombocytopenia or coagulation disorders (prothrombin activity <50% and platelet
             count <80,000 mm3);

          -  Endobronchial obstruction by the neoplasm;

          -  Major pulmonary fibrosis or lymphangitis carcinomatosis ipsilateral to the effusion;

          -  Volume drained <800 mL;

          -  No contact between the pleural surfaces after draining;

          -  Pleural or active systemic infection;

          -  Massive neoplastic infiltration of the skin;

          -  Inability to understand the quality of life questionnaire;

          -  Age less than 18 years;

          -  Previous pleural procedures (except punctures and needle biopsies).
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 47-year-old man comes to the office for routine checkup. He is complaining of chronic cough and occasional but progressive dyspnea.  Other medical conditions include hypertension and osteoarthritis.  The patient smokes a pack of cigarettes daily and does not use alcohol or illicit drugs.  He used to be a construction worker. On examination, there are decreased breath sounds and percussive dullness at the base of both lungs.  Chest CT scan reveals a mild bilateral pleural effusion and diffuse thickening of the pleura. The patient's documents show chronic exposure to asbestosis. The specimen of the lungs reveled  pulmonary fibrosis that is most predominant in the lower lobes, characterized  by the presence of asbestos bodies (golden-brown beaded rods with translucent centers).

Patient description (patient's own words): I'm a 47-year-old former construction worker. I'm a man and I smoke a pack of cigs a day but I don't drink or do drugs. I went to my routine checkup because I've been coughing so much lately. I also had shortness of breath and it got worse over time. I already suffer from hypertension and osteoarthritis. My doctor found that I have decreased breath sounds. I did a chest scan and it seems that I have fluid around my lungs, and the lining of my lungs has become thicker in many areas. I have been exposed a lot to asbestos fibers. The other lung exam showed that I have pulmonary fibrosis, especially in the lower part of my lungs and they found some asbestos there.

Does the patient match the trial criteria? 1
Clinical trial: Comparing Buccal and Vaginal Misoprostol in Management of Early Pregnancy Loss (NCT02141555)

Eligibility criteria:
Inclusion Criteria:

          -  Women ages 18-50 who are English or Spanish speaking

          -  First trimester pregnancy (less than 13 weeks and 0 days)

          -  Desires medical management of an early pregnancy loss with misoprostol

          -  Diagnosed with an early pregnancy failure by UCSD Radiology or diagnosed early
             pregnancy failure defined by any of the following criteria (Bourne 2013):

               -  Crown-rump length > 7mm with no cardiac activity

               -  Mean gestational sac diameter of > 25 mm and no embryo

               -  Absence of an embryo with heartbeat > 2 weeks after a scan showing a gestational
                  sac without a yolk sac

               -  Absence of embryo with heartbeat > 11 days after a scan showing a gestational sac
                  with a yolk sac

        Exclusion Criteria:

          -  Evidence of infection, acute hemorrhage, or hemodynamic instability

          -  Hemoglobin less than 9.5 including use of point of care Hgb testing

          -  Known allergy to misoprostol

          -  Underwent surgical or medical abortion during current pregnancy

          -  Currently breastfeeding

          -  Currently has intrauterine device in place

          -  Suspicion of ectopic or gestational trophoblastic disease

          -  History of clotting disorder or on anticoagulant therapy (excluding aspirin)

          -  Unreliable for follow up
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 1
Clinical trial: Hydrocodone For Pain Control in First Trimester Surgical Abortion (NCT01330459)

Eligibility criteria:
Inclusion Criteria:

          -  Aged 18 years or older

          -  Voluntarily requesting surgical pregnancy termination

          -  Pregnancy with intrauterine gestational sac up to 10 weeks 6 days gestation, dated by
             ultrasound

          -  Eligible for suction curettage

          -  English or Spanish speaking

          -  Good general health

          -  Able and willing to give informed consent and agree to terms of the study

        Exclusion Criteria:

          -  Gestational ages 11 weeks or more

          -  Incomplete abortion

          -  Premedication with misoprostol

          -  Use of any opioid medication within the past 7 days

          -  Use of heroin within the past 7 days

          -  Requested opioids or IV sedation prior to start of the procedure

          -  Patients who refuse ibuprofen or lorazepam

          -  Contraindications or allergies to HC/APAP, lidocaine, ibuprofen, or lorazepam

          -  Significant medical problem necessitating inpatient procedure

          -  Adnexal mass or tenderness on pelvic exam consistent with pelvic inflammatory disease

          -  Known hepatic disease
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Web-based Application for the Population Pharmacokinetic Service - Phase 1 (NCT02061072)

Eligibility criteria:
Inclusion Criteria:

          -  Patients with severe or moderate Hemophilia A or B

          -  Informed consent to data processing

        Exclusion Criteria:

          -  Non measurable plasma factor VIII due to high titre inhibitor
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1