araag2/NLI4PR huggingface dataset:
Clinical trial: Placebo-controlled Trial With OROS Hydromorphone Hydrochloride to Treat Patients With Moderate to Severe Pain Induced by Osteoarthritis of the Hip or the Knee (NCT00980798)

Eligibility criteria:
Inclusion Criteria:

          -  Documented Osteoarthritis of the hip or knee

          -  Chronic pain for more than 3 months treated with daily analgesic for the last month

          -  Moderate to severe OA pain of the target joint, which cannot be adequately treated
             with non-steroidal anti-inflamatory drugs or paracetamol

          -  Moderate to severe pain by means of a mean weekly score of >= 5 in the Brief Pain
             Invetory item 5 'pain on average'

        Exclusion Criteria:

          -  Regular treatment with an opioid in the 4 weeks before screening visit (infrequent use
             of tramadol, codeine, tilidine, or dihydrocodeine for no more than 10 days in the 4
             weeks before the screening visit is acceptable, however, treatment must be stopped at
             screening visit)

          -  Diagnosis of major depression

          -  Treatment for epilepsy

          -  Corticosteroid injection within the last 3 months

          -  Major surgery in the 3 months before the start of the study

          -  Women who are pregnant or breast-feeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Prucalopride in Pediatric Subjects With Functional Constipation (NCT01330381)

Eligibility criteria:
Main Inclusion Criteria:

          1. Boys and girls, aged ≥ 6 months and < 18 years.

          2. Subjects with a confirmed diagnosis of functional constipation as defined by the Rome
             III criteria.

        Main Exclusion Criteria:

          1. Children with underlying GI abnormalities and causes for defecation disorders.

          2. Constipation is thought to be drug-induced.

          3. Subjects suffering from secondary causes of chronic constipation.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 6 Months old.
Subject must be at most 17 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? 0
Clinical trial: Combination Iron Chelation Therapy (NCT00004982)

Eligibility criteria:
Inclusion Criteria:

          -  Iron overload

        Exclusion Criteria:

          -  Overt cardiac disease
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 7 Years old.


Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? 1
Clinical trial: Safety and Efficacy of BAY94-9027 in Previously Treated Male Children With Haemophilia A (NCT01775618)

Eligibility criteria:
Inclusion Criteria:

          -  Males < 12 years of age

          -  Subjects with severe hemophilia A

          -  Previously treated with FVIII for > 50 exposure days

        Exclusion Criteria:

          -  Subjects with current evidence of or history of inhibitors to FVIII

          -  Any other inherited or acquired bleeding disorder

          -  Platelet counts < 100,000/mm^3

          -  Creatinine > 2x the upper limit of normal

          -  Aspartate aminotransferase (AST) / Alanine aminotransferase (ALT) > 5x the upper limit
             of normal
Male
No healthy subjects accepted to join the trial.

Subject must be at most 12 Years

Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Progesterone Supplementation in Frozen Embryo Transfer Cycles (NCT03504345)

Eligibility criteria:
Inclusion Criteria:

          -  Patient at Mount Sinai Fertility who wants to undertake a frozen embryo transfer

          -  History of recurrent implantation failure, defined as no pregnancy after three or more
             embryo transfers of four or more good quality blastocysts

        Exclusion Criteria:

          -  Previous testing with Endometrial Receptivity Assay (ERA)

          -  Unable understand/communicate in English
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 55 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Dietary Advice on Prescription in Kungsbacka (NCT01385930)

Eligibility criteria:
Inclusion Criteria:

          -  BMI 28-35

        Exclusion Criteria:

          -  Severe disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 40 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? 1
Clinical trial: Esophageal Hypersensitivity Study in Patients With Gastroesophageal Reflux Disease (GERD) (NCT01019928)

Eligibility criteria:
Inclusion Criteria:

          -  Provision of signed informed consent form

          -  BMI 18.5-35.0, inclusive

          -  Continuous PPI treatment for GERD during the last 4 weeks

        Exclusion Criteria:

          -  Patients that have not experienced any GERD symptoms improvement at all after PPI
             treatment

          -  Unstable or clinically significant disorders including cardiovascular, respiratory,
             renal, hepatic, metabolic, psychiatric, other gastrointestinal and esophageal
             disorders besides GERD

          -  Prior surgery of the upper GI tract
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? 1
Clinical trial: CARE Canadian ALS Riluzole Evaluation (NCT00542412)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of ALS confirmed by the following definition:

             (a)"Probable" or "Definite" Amyotrophic Lateral Sclerosis (ALS) according to the El
             Escorial criteria(b)"Peripheral" onset form (limb involvement) or a "Bulbar" form of
             ALS with a duration of five years, based on inquiry for the earliest symptoms of the
             disease

          -  A subject who simultaneously presents with bulbar and peripheral signs at onset of ALS
             disease should be stratified to the bulbar onset group. The neurologic progression of
             such subjects matches that of the bulbar onset ALS subjects.

          -  Pulmonary Function: forced vital capacity (FVC) must be 3 60% at study entry.

          -  Females of childbearing potential must be documented to be using acceptable birth
             control methods such as an IUD or oral contraceptives.

        Exclusion Criteria:

          -  Previous treatment with riluzole

          -  Tracheostomy, or expected to undergo a tracheostomy within two months after study
             inclusion

          -  Signs of clinical dementia and/or major psychiatric disorders

          -  Serious concomitant disease or handicap likely to interfere with the subject's
             assessments or impact on the subject's survival

          -  A multiple conduction block has been shown on nerve conduction studies by
             electromyogram

        The above information is not intended to contain all considerations relevant to a patient's
        potential participation in a clinical trial.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old man comes to the clinic for the follow up of his neuromuscular disease. He experienced gradual, progressive weakness of the left upper extremity over the last year.  Over the last few months, he has also noticed weakness in the right upper extremity.  BP is 120/75, PR is 80 and temperature is 37 C. Reflexes are brisk in the upper extremities, and the plantar responses are extensor.  Mild gait ataxia is present. The patient is under treatment of Riluzole 50 mg BID with the diagnosis of ALS.

Patient description (patient's own words): I've been suffering from a neuromuscular disease for a while now, and I went to my doctor's office. I'm now a 47-year-old man and over the past year I experienced a progressive and gradual weakness of my left upper extremity, and over the past month, I also noticed a weakness over my right upper extremity. My heart rate was 120/75, and my  PR was 80 with 37°C for temperature. My reflexes are not good in my upper extremities, and I have trouble with my balance. I'm also under Exservan 50 mg for my sclerosis.

Does the patient match the trial criteria? 0
Clinical trial: Predictability of the Ability to Perform an Emergency Stop After Surgery for Inguinal Hernia (NCT03808012)

Eligibility criteria:
Inclusion Criteria:

          -  scheduled surgery for inguinal hernia of the right groin with Lichtenstein procedure

          -  valid driving license

          -  male and female

        Exclusion Criteria:

          -  lacking driving license

          -  pregnancy

          -  neuromuscular disorder (e.g. myopathy, muscular dystrophy)

          -  central neurological disorders/diseases (e.g. apoplexia, psychiatric diseases)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: Performance During Menstrual Cycle (NCT03832972)

Eligibility criteria:
Inclusion Criteria:

          -  Women

          -  18-35 years of age

          -  BMI 18.5-25.

        Exclusion Criteria:

          -  Smoking

          -  hormonal or metabolic disorders

          -  chronic sickness

          -  use of medication

          -  breast feeding, vegetarians

          -  diet containing a lot of soja based products

          -  injuries which make it impossible to do the tests
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 35 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? 0
Clinical trial: Effect of Benzalkonium Chloride Containing Eye Drops on the Conjunctival Bacterial Flora of Dry Eye Patients (NCT02533154)

Eligibility criteria:
Inclusion Criteria:

          -  Men and women aged between 18 and 75 years.

          -  Signed and dated written informed consent.

          -  History of dry eye syndrome for at least 3 months

          -  Tear Break Up Time (BUT) ≤ 10 seconds or Schirmer I test ≤ 10 mm and ≥ 2mm

          -  Normal ophthalmic findings except dry eye syndrome, ametropia < 6 Dpt.

          -  Recommended use of topical lubricants, but no administration of topical lubricants 4
             weeks preceding the first study day.

        Exclusion Criteria:

          -  History or presence of ocular disease judged by the investigator as incompatible with
             the study.

          -  Any other topical ocular treatment than the study medication in the 4 weeks preceding
             the first study day and during the treatment period.

          -  Wearing of contact lenses.

          -  Symptoms of a clinically relevant illness in the 3 weeks before the first study day.

          -  Participation in a clinical trial in the 3 weeks preceding the first study day.

          -  Pregnancy, lactation.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 40-year-old woman comes to the clinic complaining of gritty sensation in her eyes. She also has difficulty swallowing dry foods with no pain or heartburn.  The patient is a schoolteacher and must drink water frequently during lectures due to her mouth dryness.  She also reports occasional joint pain.  Medical history is not significant other than the confirmed Sjogren disease with no other rheumatologic disease.  She is sexually active with her husband and has 2 children both delivered by natural vaginal delivery. She has no history of any kind of surgery. Physical examination shows conjunctival erythema and cracking of the lips. The remainder of the examination and history is normal. Her lab result shows elevated ESR (50 mm/h)

Patient description (patient's own words): I went to the clinic because I had a terrible gritty sensation in my eyes. It was also hard to swallow dry food, but it didn't burn, and there was no pain. I'm a 40-year-old female school teacher and I should drink water for the lectures because otherwise, my mouth gets really dry. I also have joint pain from time to time. I have been diagnosed with Sjogren disease but no other rheumatologic disease. I have a husband, we're sexually active, and I also have two lovely children that I delivered both naturally. I never undergone any surgery. Physical examination when I came to the clinic, and it showed cracking on my lips and a pink eye. The rest was fine. I also did some lab tests, and they came back with high ESR.

Does the patient match the trial criteria? 0