araag2/NLI4PR huggingface dataset:
Clinical trial: Treatment of Heavy and/or Prolonged Menstrual Bleeding Without Organic Cause (NCT02943655)

Eligibility criteria:
Inclusion Criteria:

        Regular menstrual cycles with BMI (19-29 kg/m2). Heavy and/or prolonged menstrual bleeding
        involving at least last three consecutive menstrual cycles.

        Exclusion Criteria:

          1. Postmenopausal bleeding (over one year since the last menstrual period).

          2. Irregular menses or intermenstrual bleeding.

          3. Organic causes of heavy menstrual bleeding suspected or confirmed by experienced
             abdominal and transvaginal ultrasound after thorough general and gynecological
             examination.

          4. Iatrogenic (treatment-related) causes of heavy menstrual bleeding (e.g.
             non-progestogen-releasing intrauterine contraceptive device, oral contraceptives,
             other hormonal drug use or anticoagulant agent).

          5. Iron deficiency anemia.

          6. History of chronic diseases known to interfere with menstrual bleeding or prevent the
             use of any of the listed drugs e.g previous or current thromboembolic disease.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 25 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 23-year-old female has prolonged oral bleeding immediately after a tooth extraction.  Despite several interventions, the bleeding persists for hours and stops only after desmopressin (DDAVP) administration.  The patient has heavy menstrual cycles each month.  She has no other medical problems and takes no medications.  Her mother and grandmother have also had excessive bleeding during menstrual period.  Review of systems is positive for mild bruising on his legs. Laboratory findings reveal a normal platelet count and an abnormal ristocetin cofactor assay, as well as CB <= 0.30 IU/mL and FVIII:C <= 0.40 IU/mL.

Patient description (patient's own words): I'm a 23 woman and I went to the ER because of non-stop bleeding after my tooth extraction. I tried to make the bleeding stop but it just kept going for hours and it finally stopped when I took some medication called DDAVP. I usually have heavy periods, just like my mom and grandma had. I don't have any other medical condition and I don't take any other medication. The doctor noticed the bruises on my legs. I had to do some lab tests. I had a normal platelet count but an abnormal ristocetin cofactor assay. I had low CB and FVIII:C levels.

Does the patient match the trial criteria? 1
Clinical trial: Manual Therapy Versus Exercise on Knee Osteoarthritis (NCT00988468)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosis of knee osteoarthritis.

        Exclusion Criteria:

          -  Inability to ambulate at least 100 feet, ride a stationary bicycle for at least 10
             minutes, or lie in the prone position for at least 10 minutes,

          -  Intra-articular knee injection within one month of study inception,

          -  A history of exercise induced or uncontrolled angina within three months of the study
             entry,

          -  Severe dyspnea at rest,

          -  Previous bilateral total knee arthroplasty,

          -  Pregnancy, OR

          -  The absence of knee pain at the time of recruitment for the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 89 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? 1
Clinical trial: Microarray Analysis in Syndromic Obesity (NCT01043198)

Eligibility criteria:
Inclusion Criteria:

          -  children (under 18 year-old)

          -  obesity (following IOTF definition)

          -  at least one criteria among :

               -  mental retardation

               -  facial dysmorphism

               -  at least one major malformation (uro-genital, cardiac, skeletal, cerebral,
                  ophthalmologic…)

        Exclusion Criteria:

          -  common obesity

          -  obesity with an identified aetiology
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.

Subject must be at most 18 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? 0
Clinical trial: Web Accessible Population Pharmacokinetics Service - Hemophilia: Sources of Variability (NCT03533504)

Eligibility criteria:
Inclusion Criteria:

          -  individuals with hemophilia A or B

          -  infusion/PK data is available on the WAPPS-Hemo database

          -  given informed consent to data input on the WAPPS-Hemo database

        Exclusion Criteria:

        - individuals currently undergoing immune tolerance induction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 1
Clinical trial: Assessment of Day-night Secretion of Progesterone and LH Across Pubertal Maturation in Girls With and Without Hyperandrogenemia (JCM023) (NCT02155933)

Eligibility criteria:
Inclusion Criteria:

          -  Early and late pubertal girls with normal androgens

          -  Early and late pubertal girls with hyperandrogenemia

          -  All subjects will be girls from pre-puberty (Stage 1 breast development and pubic hair
             growth but at least 7 years old) to 7 years post menarche.

        Exclusion Criteria:

          -  Pregnancy

          -  Inability to comprehend what will be done during the study or why it will be done

          -  Hemoglobin <11.5 g/dL for non-African American subjects; Hemoglobin < 11.0 g/dL for
             African American subjects

          -  Persistently abnormal sodium, potassium, or bicarbonate (i.e., confirmed on repeat)

          -  Persistently elevated creatinine, hepatic transaminases, or alkaline phosphatase
             (i.e., confirmed on repeat)

          -  Total bilirubin > 1.5 times upper limit of normal (i.e., confirmed on repeat)

          -  Significant history of cardiac or pulmonary dysfunction (e.g., known or suspected
             congestive heart failure; asthma requiring intermittent systemic corticosteroids;
             etc.)

          -  Untreated hypo- or hyperthyroidism (reflected by persistently abnormal TSH values)

          -  Total testosterone > 200 ng/dl

          -  Basal (follicular) 17-OHP > 200 ng/ml (in girls without a previous diagnosis of
             congenital adrenal hyperplasia)

          -  DHEA-S > 800 mcg/dl

          -  Elevation of prolactin > 2 times upper limit of normal

          -  Weight less than 25 kg
Female
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? 0
Clinical trial: Comparison of Self Fixating Mesh to Mesh Fixation With Metallic Tacks in Laparoscopic Inguinal Hernia Repair (NCT03564535)

Eligibility criteria:
Inclusion Criteria:

          1. Unilateral inguinal hernia

          2. Age 18-80years

          3. American Society of Anesthesiologists (ASA) Grade 1 or 2

        Exclusion Criteria:

          1. Patient unfit for general anesthesia or laparoscopic surgery

          2. Large scrotal hernias

          3. Irreducible hernias

          4. Morbid obesity

          5. Previous pelvic surgery

          6. Coagulopathy

          7. Those who cannot understand the VAS score

          8. Those who did not agree to participate in the study

          9. Gastritis

         10. Gastroesophageal reflux disease

         11. Liver dysfunction

         12. kidney dysfunction
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? 1
Clinical trial: A RCT Comparing Spontaneous Natural Cycles and Human Chorionic Gonadotrophin-induced Natural Cycles in FET (NCT02197208)

Eligibility criteria:
Inclusion Criteria:

          -  Age of women <43 years

          -  Regular menstrual cycles ranging from 21-35 days with not more than 4 days variation
             between cycles

          -  Undergoing FET in natural cycles

          -  Normal uterine cavity as shown on saline sonogram performed before the IVF cycle or
             normal uterine cavity shown on pelvic scanning during the stimulated IVF cycle

          -  Endometrial thickness >=8mm in both stimulated IVF and FET cycles

        Exclusion Criteria:

          -  >3 previous IVF cycles

          -  >6 embryos replaced without pregnancy

          -  Irregular menstrual cycles

          -  Subjects requiring clomid-induced cycles and hormonal replacement (HRT) cycles

          -  History of previous FET cycles within the study period

          -  Blastocyst transfer

          -  Preimplantation genetic diagnosis treatment

          -  Use of donor oocytes

          -  Presence of hydrosalpinx not corrected surgically prior to FET

          -  Recurrent miscarriage

          -  Serum progesterone level on the day of LH surge or day of hCG >5 nmol/L or 1.5 pg/L
             (these patients will be retrospectively excluded)

          -  Refusal to join the study
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 43 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? 0
Clinical trial: Pharmacokinetics of Testosterone Lotion in the Treatment of Hypogonadal Males (NCT00372008)

Eligibility criteria:
Inclusion Criteria:

          -  Hypogonadal males between 18-70 years old with qualifying general medical health

        Exclusion Criteria:

          -  Disqualifying concurrent conditions or allergy/sensitivity to testosterone replacement
             therapy
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? 1
Clinical trial: Arthritis Patient Education for Urban African Americans (NCT00000396)

Eligibility criteria:
Inclusion Criteria:

          -  Urban African Americans with arthritis

          -  18 years or older

        Exclusion Criteria:

          -  None
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? 0
Clinical trial: Assess the Safety and Efficacy of Individually Tailored Prophylaxis With Human-cl rhFVIII in Patients With Severe Haemophilia A (NCT01863758)

Eligibility criteria:
Inclusion Criteria:

          -  Severe haemophilia A (FVIII:C < 1%) according to medical history.

          -  Male patients ≥ 18 years old.

          -  Previous treatment with a FVIII concentrate (regular prophylaxis with good compliance
             or on-demand treatment) for at least 150 exposure days (EDs).

          -  Good documentation regarding dosing and bleeding frequency in the 6 months preceding
             study start.

          -  Immunocompetence (CD4+ count > 200/microliter).

          -  HIV-negative, if positive, viral load < 200 particles/microliter or < 400,000
             copies/mL.

          -  Freely given written informed consent

        Exclusion Criteria:

          -  Any coagulation disorder other than haemophilia A.

          -  Present or past FVIII inhibitor activity (> 0.6 Bethesda Unit [BU])

          -  Severe liver or kidney disease.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? 0
Clinical trial: Effects of Infant Massage on Development of Down Syndrome Babies (NCT03084497)

Eligibility criteria:
Inclusion Criteria:

          -  Babies with Down Syndrome that received Early Attention.

        Exclusion Criteria:

        Babies with Down syndrome:

          -  With associated pathology.

          -  Adopted.

          -  Have received infant massage course.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 4 Months old.
Subject must be at most 8 Months

Patient description (medical language): A 15-week-old infant brought to the clinic for the follow up. The infant has flat facies, small ears, a single palmar crease, and upward slanting eyes. He was born on 39th week to a 39-year-old woman who didn't have prenatal care. The medical record confirms the trisomy of chromosome 21 (Down syndrome). The infant is otherwise healthy.

Patient description (patient's own words): My newborn, who is only 15 weeks old, had one of his follow-up appointments. The doctor pointed out that my baby had a flat face, small ears, only one palm line, and small eyes. He was born on his 39th week, while I was 39. What a coincidence! To be honest, I did not go to the doctor during my pregnancy. The doctor diagnosed my baby with Down syndrome. Apart from that he's healthy.

Does the patient match the trial criteria? 1