araag2/NLI4PR huggingface dataset:
Clinical trial: Observational Study of Patients Suffering From Endometriosis and Adenomyosis (NCT04862000)

Eligibility criteria:
Inclusion Criteria:

          -  with endometriosis or adenomyosis confirmed by ultrasound or MRI

        Exclusion Criteria:

          -  refuse to participate in the study, less than 18 years old, menopausal, illiterate or
             mentally incapable
Female

Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: Comparative Clinical Efficacy and Safety of Coded Polyherbal Medicine for the Management of Arthritis (NCT03506919)

Eligibility criteria:
Inclusion Criteria:

          -  Patients suffering from Arthritis

        Exclusion Criteria:

          -  Patients with Hypertension, Cardiovascular disorders and Kidney disorders were
             excluded
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 15 Years old.
Subject must be at most 60 Years

Patient description (medical language): A 39-year-old man comes to the emergency department with an acute onset of severe left toe pain.  The toe is red and exhibits swelling. The patient is not febrile, and does not remember any recent trauma. Medical history is not significant except for the similar attacks and the diagnosis of gouty arthritis. His medication history includes Allopurinol to prevent gouty attacks. His father has the same medical condition. However, his older brother who is 41 years old is healthy with no history of gouty arthritis. Physical examination shows a swollen, tender first metatarsophalangeal joint.  Aspiration of the joint showed high leukocyte count, negative Gram stain, and numerous needle-shaped crystals, which is compatible with gouty arthritis.

Patient description (patient's own words): I'm a 39-year-old man and got admitted to the ER after an unbearable pain in my left toe. My toe was red and terribly swollen. I was still standing on my feet, not febrile and I don't remember hitting my head or anything. I don't have any special medical history, but I had been diagnosed with gout before. I take Lopurin to prevent my gouty attacks. My dad had the same problem, but my 41-year-old brother is healthy and does not have gouty attacks. The doctor did a physical exam and found that the joints between my toes and the rest of my foot were swollen and tender. The doctor renewed his diagnosis of gouty arthritis.

Does the patient match the trial criteria? Entailment
Clinical trial: Subcutaneous vs. Intramuscular Testosterone (NCT03091348)

Eligibility criteria:
Inclusion Criteria:

          -  Ability to read, write, and understand English

          -  Age greater than or equal to 18

          -  Diagnosed with testosterone deficiency

          -  Pre-enrollment testosterone concentration of less than 350 ng/dL

          -  Planning to initiate testosterone treatment at MHB

          -  Willing to be followed at MHB for at least one month

          -  Willing to provide informed consent for this study

        Exclusion Criteria:

          -  Previous exposure to exogenous T, clomiphene citrate, or other Selective Estrogen
             Receptor Modulators, unless off therapy for at least 12 weeks

          -  American Urological Association Prostate Symptom score of 15 or greater or significant
             prostatic symptoms

          -  History of carcinoma, tumors or induration of the prostate or the male mammary gland,
             including suspicion thereof

          -  Pre-enrollment serum PSA more than 4 ng/ml

          -  Serious psychiatric disease or uncontrolled medical illness, as suspected from the
             history or clinical examination

          -  Used any sex hormones or steroidal anabolic drug supplements within 28 days before
             pre-enrollment testosterone collection or at any time throughout the study

          -  Incapable of giving informed consent or complying with the protocol
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: Testing of a New Scale Measuring Medical Outcomes of Dysphagia (MOD) in Adult Patients With Swallowing Disorders (NCT01419886)

Eligibility criteria:
Inclusion Criteria:

          -  Adult (18+ years)

          -  Any disease etiology, including but not limited to: previous or current diagnosis of
             head and neck cancer (treatment may include surgery, radiation or chemotherapy, or a
             combination of more than one), stroke, cervical spine abnormality, brain tumour,
             cardiovascular surgery, and Parkinson's disease

          -  Current diagnosis of dysphagia, as determined by a speech language pathologist

          -  English-speaking

        Exclusion Criteria:

          -  No dysphagia

          -  Cognitive impairment

          -  Limited fluency in English
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic complaining of difficulty swallowing both liquids and solid foods, as well as occasional cough while eating.  She also has difficulty lifting her arms above her head and getting up from a chair. The weakness seems to get worse gradually. The patient has no prior medical problems and takes no medications.  Vital signs are normal.  Physical examination shows an erythematous rash on the upper eyelids. There are some red papules over joints of her hands. The rest of the physical examination is unremarkable. Antinuclear antibodies, anti-Jo-1 antibodies and anti-MDA5 antibody are positive.  Muscle biopsy shows perifascicular inflammation and atrophy of the fascicle and surrounding blood vessels.

Patient description (patient's own words): I had to go to the clinic because of difficulty swallowing all kinds of food, liquid and solid. I also sometimes cough when I eat my dinner. At only 50 year old, I had some difficulties lifting up my arms and getting up from a chair! And it's only getting worse! I never had any medical issues in the past and I'm not under any medication, I just don't get it! My vitals were normal. The physical exam showed a red rash on my upper eyelids. I also have red papules on my hands' joints. After a blood test, they told me that my antinuclear antibodies, anti-Jo-1 antibodies, and anti-MDA5 antibodies were positive.  I also did a muscle biopsy and it showed that I had an atrophy of my blood vessels around my muscle fibers and that I have an inflammation of these.

Does the patient match the trial criteria? Entailment
Clinical trial: Vital Signs Patch Early Feasibility and Usability Study (NCT02521922)

Eligibility criteria:
Inclusion Criteria:

          -  Adult male and female in-patients with vital signs considered 'stable' by clinical
             caregivers.

        Exclusion Criteria:

          -  Pediatric patients

          -  Female patients who are pregnant

          -  Patients with internal or external defibrillators

          -  Patients who have undergone surgery and still have a fresh incision on the chest.

          -  Patients with skin damage on the chest such as burns, irritation, infections, wounds,
             etc.

          -  Patients in the Critical Care Unit (CCU)

          -  Patients who otherwise satisfy any of the contraindications associated with the VSP
             system.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Comparison of Total and Partial Fundoplication During Surgery of Patients With Gastroesophageal Reflux Disease (NCT03659487)

Eligibility criteria:
Inclusion Criteria:

          -  surgery treatment for GERD

          -  laparoscopic surgery

        Exclusion Criteria:

          -  previous surgery for GERD

          -  ASA classification >3

          -  paraesophageal hernias or large hiatal
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Cyclic Variation in Micronutrient Concentrations and Plasma Volume (NCT03422809)

Eligibility criteria:
Inclusion Criteria:

          -  Female

          -  18 to 44 years of age

          -  General good health (does not have a known, ongoing health condition/medical issue
             that requires regular monitoring by a doctor or regular visits to the hospital)

          -  BMI 18.5-24.9 kg/m2

          -  Regular menstrual cycle (26-35 days)

          -  Non-smoker

          -  Non-pregnant

          -  If pregnant before, ≥12 months since last pregnancy

        Exclusion Criteria:

          -  Known allergy to shellfish or iodine

          -  Blood pressure on the day of measurements is low or high (systolic blood pressure
             (SBP) <90 or ≥130 mmHg and/or diastolic blood pressure (DBP) <60 or ≥80 mmHg)

          -  Currently has low or high blood pressure (SBP <90 or ≥130 mmHg and/or DBP <60 or ≥80
             mmHg), self-reported

          -  Current hypertension or previous hypertensive disorder in pregnancy (gestational
             hypertension or preeclampsia)

          -  Taking regular medication(s) (physician's prescribed medications for a health
             condition)

          -  Currently trying to conceive

          -  Currently breastfeeding

          -  Currently using hormonal birth control or used within last 3 months

          -  Used depot medroxyprogesterone acetate (DMPA) in the past 12 months

          -  Diagnosis of polycystic ovary syndrome
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 44 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: Implementation of PPI Medication PGX Testing (NCT02794844)

Eligibility criteria:
Inclusion Criteria:

          -  Children diagnosed with Gastroesophageal Reflux Disease (GERD) or a stomach acid
             mediated condition for which a PPI is prescribed.

          -  Currently taking or will be prescribed Proton Pump Inhibitor (PPI) medication

          -  Parents/legal guardians and or child must also have access to the internet and a valid
             email address to complete weekly required forms.

        Exclusion Criteria:

          -  Children who have had peptic ulcer surgery;

          -  with a history of PKU

          -  with a history of previous adverse effects from PPI treatment or a sensitivity to
             aspartame (NutraSweet, Equal);

          -  who are non-adherent including inability or unwillingness of the legal guardian to
             provide consent of unwillingness of the child to provide assent;

          -  who are unable to take study medications;

          -  who are unable to communicate via telephone or other device;

          -  who do not have access to a computer with internet access
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Pregnancy Rate by HCG Administration Versus Urinary LH Surge Method in Patients Undergoing IUI (NCT02638285)

Eligibility criteria:
Inclusion Criteria:

          -  infertile women candidate for IUI

        Exclusion Criteria:

          -  women with negative urinary LH surge which required HCG administration,

          -  those with more than 5 follicles who had to use LH kit and not receive HCG to avoid
             ovarian hyperstimulation.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers



Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: PTHrP and Osteoporosis (NCT00021827)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy caucasian postmenopausal females between 50-75 years of age with low bone
             mineral density at the lumbar spine or hip as measured using dual energy x-ray
             absorptiometry or DXA.

          -  ON estrogen replacement treatment for at least three years.

        Exclusion Criteria:

          -  Heart, vascular, kidney, liver, lung, hormonal, musculo-skeletal disease (other than
             osteoporosis), rheumatic, blood diseases are exclusion criteria.

          -  High blood pressure

          -  Pregnancy

          -  Cancer

          -  Alcohol or drug dependence

          -  Prior use of a drug treatment for osteoporosis such as PTH, bisphosphonates,
             raloxifene, or calcitonin within the preceding five years
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment