araag2/NLI4PR huggingface dataset:
Clinical trial: Geniculate Artery Embolization for the Treatment of Knee Pain (NCT02850068)

Eligibility criteria:
Inclusion Criteria:

          -  Moderate to severe knee pain (visual analog scale (VAS) > 50 mm), and

          -  Pain refractory to at least 3 months* of conservative therapies (anti-inflammatory
             drugs, or physical therapy, or muscle strengthening, or intra-articular injections),
             and

          -  Kellgren-Lawrence grade 1, 2 or 3 on radiograph of the knee.

        Exclusion Criteria:

          -  Current local infection, or

          -  Life expectancy less than 6 months, or

          -  Known advanced atherosclerosis, or

          -  Rheumatoid or infectious arthritis, or

          -  Prior knee surgery, or

          -  Uncorrectable coagulopathy including international normalized ratio (INR) > 2.5 or
             platelets < 30,000, or

          -  Iodine allergy resulting in anaphylaxis, or

          -  Renal dysfunction as defined by serum creatinine >1.6 dl/mg obtained within the past
             30 days.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Favipiravir in Hospitalized COVID-19 Patients (NCT04359615)

Eligibility criteria:
Inclusion Criteria:

          -  Age ≥ 18

          -  COVID-19 Confirmed Cases (Reverse transcription polymerase chain reaction (RT-PCR)
             Confirmed).

          -  Tympanic Temperature of ≥37.5 AND at least one of the following: Cough, Sputum
             production, nasal discharge, myalgia, headache or fatigue) on admission.

          -  Time of onset of the symptoms should be acute ( Days ≤ 10).

          -  SpO2 ≤ 93%

          -  Respiratory Rate ≥ 22

        Exclusion Criteria:

          -  Refusal to participate expressed by patient or legally authorized representative if
             they are present.

          -  Patients with prolonged QT or PR intervals, Second or Third Degree heart block and
             Arrhythmias.

          -  Patients using drugs with potential interaction with Favipiravir or
             Hydroxychloroquine.

          -  Pregnant or lactating women.

          -  History of alcohol or drug addiction in the past 5 years.

          -  Blood Alanine transaminase/aspartate aminotransferase (ALT/AST) levels > 5 times the
             upper limit of normal on laboratory results.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Detailed Clinical, Biochemical and Genetic Characterization in Gonadotropin-releasing Hormone (GnRH) Deficiency Disorders (NCT01165619)

Eligibility criteria:
Inclusion Criteria:

          -  Over the age of 18 for men

          -  Between the ages of 18 and 40 for women

          -  For reproductive disorder population: Current or previous diagnosis of Idiopathic
             Hypogonadotropic Hypogonadism or Hypothalamic Amenorrhea

        Exclusion Criteria:

          -  chronic disease (hypertension, high cholesterol, diabetes, asthma, etc)

          -  polycystic ovarian syndrome for women

          -  prescription medication use (other than allergy meds) for control populations

          -  irregular menstrual cycles for healthy female control population (cycle length longer
             than 35 days or shorter than 25 days. cycle length varies by more than 5 days. less
             than 9 periods per year)
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: TFPI Levels in Haemophilia A and B Patients (NCT04570696)

Eligibility criteria:
inclusion criteria :

          -  Men, adult (≥ 18 years old), haemophilia A or B disease (whatever the severity)

          -  Follow-up consultation in our center

          -  Blood samples collection planed during the consultation exclusion criteria :

          -  Children (< 18 years old), women

          -  No blood samples collection planed during the follow-up consultation
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Entailment
Clinical trial: SurgeCon: An Emergency Department Surge Management Platform (NCT04789902)

Eligibility criteria:
Inclusion Criteria:

          -  All individuals who visit any of the four selected emergency departments during the
             study period will be included.

        Exclusion Criteria:

          -  none
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 23-year-old woman comes to the emergency department with a history of nosebleeds lasting for 1 hour. She has a history of heavy menses as well as occasional gum bleeding following dental procedures. Her mother also has a history of menorrhagia. Laboratory tests reveal increased bleeding time and slightly increased partial thromboplastin time. She has no other medical conditions and is otherwise healthy. Her coagulation study shows CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL. She is not smoking or using any kind of illicit drugs. She uses alcohol occasionally and is in ra elationship with her boyfriend for the past 2 years.

Patient description (patient's own words): I had to rush to the ER because of a non-stop nosebleed that had been on for 1 hour. As a 23-year-old, I always had heavy periods, and sometimes, my gums would bleed after going to the dentist or brushing my teeth. I thought that it was not very alarming since my mom also had heavy periods. I did some lab tests that showed that I had increased bleeding time and long clotting time. Otherwise, I'm pretty healthy, and I don't smoke or take any kind of drugs. I drink only at parties from time to time. I have been with my boyfriend for the last 2 years. I did a coagulation study and I got the following results: CB = 0.30 IU/mL and FVIII:C = 0.37 IU/mL.

Does the patient match the trial criteria? Entailment
Clinical trial: Aromatase Inhibitors, Alone And In Combination With Growth Hormone In Adolescent Boys With Idiopathic Short Stature (NCT01248416)

Eligibility criteria:
Inclusion Criteria:

          -  Males: Ages: 12 - less than 18 years.

          -  Bone age less than 14 ½ years at study initiation.

          -  Presence of puberty.

          -  Idiopathic short stature will be defined as a short child equal or less than -2SD for
             height, with normal GH responses to stimuli (> or = 5ng/ml to at least 2
             secretagogues) or a normal IGF-I and BP-3, normal body proportions and no other
             identifiable growth pathology.

          -  Accurate growth data for at least 6 months at baseline is available.

        Exclusion Criteria:

          -  Chronic illnesses.

          -  Chronic use of glucocorticosteroids.

          -  Previous use of hormonal treatment with AIs, sex steroids or GH in the preceding 6
             months.

          -  Birth weight small for gestational age (SGA).
Male
No healthy subjects accepted to join the trial.
Subject must be at least 12 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 3-year-old girl is brought to the clinic by her parents for assessment of her short stature. Physical examination reveals short limbs and a relatively large head. She has a flat nasal bridge and a small midface. The girl's father exhibits similar physical features; however, her mother looks normal. The genetic testing reveals an autosomal dominant point mutation in the fibroblast growth factor receptor 3 (FGFR3) gene consistent with achondroplasia in both father and the child. The girl has not received any treatment yet, and it is her first visit after immigration to the US. The other mental and developmental examinations are unremarkable.

Patient description (patient's own words): I just brought my little 3-year-old girl to the clinic to have her checked up by the doctor. I was worried sick because she was smaller than her classmates. The lovely doctor performed a physical exam and she told me that she has short limbs and a larger head. My girl also has a flat nasal bridge and a small midface. My baby just has the face of her father, unlike me! They performed some genetic testing on my child and my husband and found out that both my husband and her have a mutation of the FGFR3 gene, which led the doctor to diagnose them with dwarfism. My baby never received any treatment and it was our first visit to the doctor since we arrived in the US. The other tests regarding her mental and physical development were perfectly fine.

Does the patient match the trial criteria? Contradiction
Clinical trial: Using Hypnotherapy For Dementia & Alzheimer's (NCT01435551)

Eligibility criteria:
Inclusion Criteria:

          -  Diagnosed having Alzheimer

          -  Under doctor's care

        Exclusion Criteria:

          -  Must be able to follow instructions
No condition on gender to be admitted to the trial.




Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: D3-GHR Polymorphism and Turner Syndrome (NCT00443144)

Eligibility criteria:
Inclusion Criteria:

          -  Turner syndrome defined by a structural aberration or lack of the X chromosome.

          -  Growth velocity less than 2 cm/year at the time of final analysis (= final height).

        Exclusion Criteria:

          -  Age <3.5 or >14 years at start of GH therapy,

          -  GH peak serum levels < 8 ng/ml in two independent tests,

          -  Thelarche at start or during the first year of treatment,

          -  Oxandrolone therapy for any time and a duration of GH therapy less than 2 years.
Female

Subject must be at least 38 Months old.
Subject must be at most 14 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Entailment
Clinical trial: A Study of Fortigel Testosterone Gel 2% in Males With Low Testosterone (NCT00522431)

Eligibility criteria:
Inclusion Criteria:

          -  Men aged 18 - 75 years with primary or secondary hypogonadism as confirmed by:

               -  Single serum total testosterone concentration < 250 ng/dL, or

               -  Two consecutive serum total testosterone concentrations < 300 ng/dL (determined
                  at least one week apart during the screening period).

          -  Has a BMI ≥ 22 kg/m2 and < 35 kg/m2.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 19-year-old male came to clinic with some sexual concern.  He recently engaged in a relationship and is worried about the satisfaction of his girlfriend. He has a "baby face" according to his girlfriend's statement and he is not as muscular as his classmates.  On physical examination, there is some pubic hair and poorly developed secondary sexual characteristics. He is unable to detect coffee smell during the examination, but the visual acuity is normal. Ultrasound reveals the testes volume of 1-2 ml. The hormonal evaluation showed serum testosterone level of 65 ng/dL with low levels of GnRH.

Patient description (patient's own words): I'm 19 years old guy and I just went to see a doctor at the clinic after I just got with my girlfriend. I'm kinda worried because she thinks that I have a baby face and to be honest, I'm way less muscular than my classmates. I don't have much hair down there, and yes, I don't have that macho look. The doctor made me smell some coffee and I couldn't smell anything special. I also had some eyesight checkups and the doctor told me everything was normal. I got my test results back and it says: testes volume is 1-2 ml and serum testosterone level of 65 ng/dL with low GnRH levels.

Does the patient match the trial criteria? Entailment
Clinical trial: OTO-313 in Subjects With Unilateral Subjective Tinnitus (NCT04829214)

Eligibility criteria:
Inclusion Criteria:

          -  Subject has early-onset subjective unilateral tinnitus that is persistent
             (consistently aware of their tinnitus throughout much of the waking day).

          -  Subject is able to use the diary to complete their daily tinnitus ratings.

          -  Subject's tinnitus is likely of cochlear origin, e.g., associated with sensorineural
             hearing loss; acute hearing loss from noise trauma, barotrauma, or traumatic cochlear
             injury (acute acoustic trauma, blast trauma, middle ear surgery, inner ear
             barotrauma); age related hearing loss; resolved otitis media; ototoxic drug exposure.

          -  Subject is willing to comply with the protocol and attend all study visits.

        Exclusion Criteria:

          -  Subject has pulsatile tinnitus, temporomandibular joint disease (TMJ) associated with
             tinnitus perception, tinnitus resulting from traumatic head or neck injury, or
             tinnitus resulting from a tumor or stroke.

          -  Subject is pregnant, lactating, or undergoing fertility treatment.

          -  Subject has other clinically significant illness, medical condition or medical history
             at Screening or Baseline that, in the Investigator's opinion, would likely reduce the
             safety of study participation or compliance with study procedures.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Entailment