araag2/NLI4PR huggingface dataset:
Clinical trial: Gastric Activity and Gastrointestinal Peptides in Patients With Functional Dyspepsia (NCT02113527)

Eligibility criteria:
Inclusion Criteria:

          -  Patients suffering from dyspeptic symptoms according to Rome III;

          -  Helicobacter pylori negative subjects;

          -  age 19-70 yr.;

          -  willingness to complete the study;

          -  not recent administration (in the 2 months before the examination) of
             anti-inflammatory drugs (NSAIDs), antibiotics, bismuth, antacids, H2-receptor
             antagonists, proton pump inhibitor, sucralfate or misoprostol;

          -  at least one endoscopic/radiological GI evaluation in the last 5 yrs.

        Exclusion Criteria:

          -  previous history of gastric tumors or gastric surgery

          -  lactose intolerance;

          -  celiac disease, wheat sensitivity;

          -  alarm symptoms (GI bleeding, weight loose etc.);

          -  psychiatric diseases;

          -  familial history of peptic ulcer;

          -  gastric cancer or IBD;

          -  abnormal thyroid function;

          -  other exclusion criteria (namely, pregnancy, breast-feeding, and drug allergies).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: The Efficacy of a Self-fixating Mesh in Unilateral Open Inguinal Hernia Repair (NCT01596049)

Eligibility criteria:
Inclusion Criteria:

          -  All patients undergoing primary unilateral open Inguinal Hernia Repair .

          -  patients undergoing elective surgery.

          -  above the age of 18 years old

        Exclusion Criteria:

          -  patients having repeated Inguinal Hernia.

          -  patients having bilateral Hernia.

          -  patients undergoing laparoscopic surgery.

          -  patients undergoing non-elective surgery.
Male
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 49-year-old man comes to the office because of the bulging in his groin.  Physical examination shows a swelling above the inguinal ligament. When the patient is asked to cough, the size of the bulge increases.  His medical history is significant for mild dyslipidemia, which is under control by lifestyle modifications. He does not smoke, but drinks alcohol occasionally. His vital signs and other physical examinations are unremarkable. He is referred to a surgeon and scheduled to undergo elective laparoscopic hernia repair.

Patient description (patient's own words): I'm a 49-year-old man and I went to my doctor the other day because I could not stand that sharp pain in my upper thigh, it was so swollen! The doctor told me that it was swollen right next to my ligament. It's even bigger when I'm coughing. I'm suffering from high cholesterol and I already had to adapt my lifestyle to keep the disease under control. I do not smoke but to be honest I still drink from time to time. The doctor found my vitals normal. She gave me a note to see a surgeon to get my mass removed and get a hernia repair.

Does the patient match the trial criteria? Entailment
Clinical trial: Bromelin, a Compound Prepared With Ananas Comocus Extract and Honey, for Acute Cough (NCT01356693)

Eligibility criteria:
Inclusion Criteria:

          -  cough for less than 24 hours

          -  common cold symptoms : nasal obstruction, headache, myalgias, runny nose.

        Exclusion Criteria:

          -  declared chronic pulmonary diseases declared Nervous diseases declared Diabetes
             declared cardiac diseases known primary or secondary immunodeficiencies
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 2 Years old.
Subject must be at most 15 Years

Patient description (medical language): The patient is a 38-year-old man with cough and body ache that started 3 days ago.  He had fever and chills at the beginning and has low grade fever at the time of visit. He feels tired and sleepy. His body ache and myalgia get better after using Tylenol. The PCR test for Covid is positive. His vital signs are within normal limits with a body temperature of 37.9 C. There is no lymphadenopathy or white exudates in the pharynx.

Patient description (patient's own words): I was feeling really sick the other day, to the point that I showed up at the doctor's office. I was coughing, and my body was hurting for 3 days. I had a fever and chills and felt tired and sleepy. I got better after using Tylenol. They did a PCR Covid test on me, and it was positive! My vitals were normal, and my temperature was 37.9 C. I had no swelling around my neck or white spots on the back of my throat.

Does the patient match the trial criteria? Contradiction
Clinical trial: Oesophageal Acid Exposure in Healthy Subjects Over 96 Hours (NCT03417817)

Eligibility criteria:
Inclusion Criteria:

          -  Asymptomatic in:

               -  GORD according to the Montreal GORD consensus definition

               -  Dysphagia using the Hospital Odynophagia Dysphagia Questionnaire (HODQ) scoring <
                  7

          -  People without reflux referred for gastroscopy in context of other conditions e.g.
             iron deficiency anaemia, coeliac disease.

          -  Subjects must sign an informed consent

        Exclusion Criteria:

          -  Gastro-oesophageal symptoms in accordance with Montreal criteria

          -  Previous abdominal operations on GI tract

          -  Antireflux treatments either prescribed or over the counter

          -  BMI > 35

          -  History of hepatic diseases, oesophageal varices

          -  History of ischemic heart disease, asthma

          -  Anticoagulants

          -  Allergies

          -  Pregnancy

          -  Any medical or non-medical condition that in the opinion of the research team will
             make the candidate unfit for this study e.g. drug abuse etc.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effect of Growth Hormone in Very Young Girls With Turner Syndrome (NCT00406926)

Eligibility criteria:
Inclusion Criteria:

          -  Karyotype-proven Turner syndrome that included a documented abnormality of the short
             arm of an X chromosome.

          -  At least 9 months of age and not greater than 4 years of age.

          -  Normal values for age for hemoglobin, thyroid stimulating hormone (TSH) and urinalysis
             (office dipstick is adequate), performed prior to study entry.

          -  If there was a known history of hypothyroidism, then adequate thyroid hormone
             replacement must have been taken for at least 6 months prior to study entry.

        Exclusion Criteria:

          -  Current or previous treatment with any therapy that may have directly influenced
             growth, including growth hormone, growth hormone-releasing hormone, estrogens and
             anabolic steroids such as oxandrolone. This included previous completion of, or
             withdrawal from, this study or any other study investigating therapeutic uses of
             growth hormone or growth hormone-releasing hormone.

          -  Chronic treatment with systemic glucocorticoids in supra-physiological doses.

          -  Treatment with potential growth-influencing medications such as methylphenidate
             (Ritalin), pemoline (Cylert), and amphetamines, at, or within 3 months prior to, study
             entry.

          -  Presence of any Y chromosome component in the karyotype if gonads were in situ.
             Subjects whose karyotype contained Y chromatin, but who had undergone gonadectomy,
             were eligible to enter the study.

          -  Presence of any additional known autosomal abnormality.
Female
No healthy subjects accepted to join the trial.
Subject must be at least 9 Months old.
Subject must be at most 4 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Morphological Markers of Gastroesophageal Reflux Disease (GERD) (NCT01921686)

Eligibility criteria:
Inclusion Criteria for GERD or EoE Subjects:

          -  Children between the ages of 8-18 years

          -  Suspected diagnosis of GERD or EoE based on symptom criteria

          -  Able to tolerate upper endoscopy examination with biopsies

        Inclusion Criteria for Control Subjects:

          -  Children between the ages of 8-18

          -  Scheduled for EGD for clinical indications

          -  No history of esophageal disease of esophageal symptoms

          -  Able to tolerate upper endoscopy examination with biopsies

        Exclusion Criteria for GERD or EoE Subjects:

          -  History of Barrett's esophagus

          -  Previous esophageal or gastric surgery

          -  History of congenital defect/malformation of the esophagus

          -  Diagnosis of Crohn disease

        Exclusion Criteria for Control Subjects:

          -  Symptoms of GERD or EoE (including heartburn, regurgitation, difficulty swallowing,
             painful swallowing).
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 8 Years old.
Subject must be at most 18 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Using Microfluidic Separation Sperm Selection for Unexplained Infertility and Reccurrent Implantation Failure (NCT03355937)

Eligibility criteria:
Unexplained Infertility Group; The inclusion criteria are;

          1. normal HSG,

          2. normal hormone levels,

          3. normal over functions,

          4. having normal uterine cavity and endometrial thickness determined by office
             hysteroscopy

          5. no endometriosis (determined by transvaginal ultrasonography and / or diagnostic
             laparoscopy)

          6. normal spermiogram result Recurrent Implantation Failure The inclusion criteria are;

        1-The inclusion criteria of the working group are: 2-Failure of embryo transfer at least
        twice after high quality embryo transfer after 3-IVF treatment, 4-having normal hormone
        reserve (FSH <8 mIU / mL), 5-respond well to hormone stimulation (> 8 oocyte collection),
        6-having normal uterine cavity and endometrial thickness determined by office hysteroscopy
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 20 Years old.
Subject must be at most 40 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Survey on the Success of Inhibitor Elimination Using Individualized Concentrate Selection and Controlled ITI (NCT02207894)

Eligibility criteria:
Inclusion Criteria:

          -  Based on the decision of the treating physicians in the participating centres, male
             patients at any age suffering from severe (FVIII activity < 1%), moderate (FVIII
             activity >1% - 5%), or mild (FVIII activity > 5%) haemophilia A will be included into
             this post marketing observation if relevant inhibitor levels (> 0.6 BU) have been
             detected, or - in case of an inhibitor level <0.6 BU - with reduced recovery or
             half-life of FVIII.

          -  The observation is also open for patients who failed an earlier ITI attempt.

        Exclusion Criteria:

          -  Female
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): A 20-year-old man comes to the emergency due to bleeding after a tooth extraction.  The bleeding has persisted for approximately 30 minutes despite constant direct pressure.  He is a known case of Hemophilia type A treated with FVIII. Blood pressure is 95/60 mm Hg and pulse is 105/min. His weight is 70 Kg. Family history is positive for Hemophilia type A in his maternal uncle. He also has a lipoma on his left arm which he plans to remove surgically. His FVIII activity is 40%.

Patient description (patient's own words): I got my tooth extracted and I could not stop bleeding for 30 min. I'm a 20 yo dude but I have Hemophilia type A treated with FVIII. My blood pressure was 95/60 and my pulse 105/min. I'm 70 kg. My uncle on my mom's side also has type A hemophilia. I also have a fatty swelling on my left arm and I was supposed to remove it. My FVIII activity was 40%.

Does the patient match the trial criteria? Contradiction
Clinical trial: Clinical Effectiveness of Frozen Thawed Embryo Transfer Compared to Fresh Embryo Transfer (NCT02570386)

Eligibility criteria:
Inclusion Criteria:

          -  Women under 42 years of age

          -  Presence of at least 3 embryos suitable to freeze on day 2 or 3 following
             fertilisation based on the centre's criteria

          -  Written informed consent

        Exclusion Criteria:

          -  Women using donor eggs/donor sperm

          -  Women undergoing preimplantation genetic diagnosis

          -  Women with abnormal uterine cavity shown on hysterosalpingogram or saline infusion
             sonogram

          -  Women with hydrosalpinges shown on scanning and not corrected treated

          -  Women with excessive ovarian response at risk of ovarian hyperstimulation where
             elective freeze is already planned

          -  Women with serum progesterone level on day of human chorionic gonadotrophin>1.5ng/ml
             or 5 nmol/L

          -  Women whose embryos have not survived freeze-thawing in the past

          -  Fresh transfer is planned e.g. patients with endometriosis or adenomyosis who have
             received prolonged downregulation

          -  Only frozen transfer is planned e.g. patients receiving ovarian stimulation regimens
             which may have adverse impacts on the endometrium
Female
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 42 Years

Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effect of Virtual Reality Exercises on Balance in Patients With Osteoporosis (NCT04780997)

Eligibility criteria:
Inclusion Criteria:

          -  diagnosed with primary osteoporosis

        Exclusion Criteria:

          -  history of inflammatory rheumatic disease

          -  history of vestibular and cerebellar disease

          -  diseases affecting the central and peripheral nervous system (Parkinson's, stroke,
             ataxia, dementia, multiple sclerosis, peripheral neuropathy
Female
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Entailment