araag2/NLI4PR huggingface dataset:
Clinical trial: Clinical Trial to Evaluate the Efficacy and Safety of EsoDuo Tab. 20/800mg (NCT03928470)

Eligibility criteria:
Inclusion Criteria:

          1. Male or Female aged ≥ 19 years

          2. Episode of heartburn for 3 months or more during prior to randomization visit.

          3. Episode of heartburn for 2 days or more during the last 7 days prior to randomization
             visit.

          4. Grade N, M by EGD test.

        Exclusion Criteria:

          1. Surgery history on stomach or esophagus

          2. Active medical history of stomach, esophagus area

          3. Other system disorder which can disturb this trial

          4. Patients taking the contraindication of concomitant medications

          5. Clinically significant Abnormal Lab test

          6. Pregnant woman, Breastfeeding woman.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 19 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Postural Analysis in Patients With Knee Osteoarthritis (NCT01031576)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of Osteoarthritis Disease

        Exclusion Criteria:

          -  Others Disease orthopedics
Female
Accepts Healthy Volunteers
Subject must be at least 60 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: Safety and Efficacy of Iron Reduction by Phlebotomy (NCT00689182)

Eligibility criteria:
Inclusion Criteria:

          -  consecutive patients who have undergone autologous or allogeneic HSCT

          -  who are red-cell transfusion-independent

          -  at least 60 days post-transplant

          -  serum ferritin of at least 1000ug/L

          -  ECOG less than or equal to 2.0

        Exclusion Criteria:

          -  pregnancy

          -  breast-feeding

          -  serious infection

          -  HIV antibody positive

          -  renal failure (creatinine < 30ml/min)

          -  sever obstructive lung disease

          -  have a pacemaker, cerebral aneurysm or metal prosthesis

          -  evidence of disease relapse
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 65 Years

Patient description (medical language): A 51-year-old man comes to the office complaining of fatigue and some sexual problems including lack of libido. The patient doesn't smoke or use any illicit drug.  Blood pressure is 120/80 mm Hg and pulse is 70/min.  Oxygen saturation is 99% on room air.  BMI is 24 kg/m2.  Skin examination shows increased pigmentation. Genotype testing is consistent with homozygosity for the C282Y mutation. Laboratory study shows transferrin saturation of 55% and serum ferritin of 550 μg/L. He is diagnosed as a case of hemochromatosis.

Patient description (patient's own words): I am 51 years old and I just came back from the doctor's office. I'm sick and tired of being that exhausted, reaching the point where me and my lovely wife are not touching each other anymore! I'm not smoking or doing drugs! My blood pressure was 120/80 mm Hg, and pulse was 70/min and my oxygen saturation 99%. My BMI is 24. My skin also turned a bit darker lately. He tested my genes and told me that I have a mutation of the C282Y gene. I also did lab tests where my transferrin saturation was 55% and serum ferritin was 550  μg/L. The doctor diagnosed me with iron overload.

Does the patient match the trial criteria? Contradiction
Clinical trial: Study of the Long-term Effects of Exercise on Heath Indicators in Older People (NCT01874132)

Eligibility criteria:
Inclusion Criteria:

          -  Older adults living independently;

          -  medical approval.

        Exclusion Criteria:

          -  Non-smokers;

          -  Non-morbidly obese;

          -  No history of severe hypertension;

          -  No history of falls;

          -  No orthopaedic, neurological, pulmonary, or cardiac problems.
Male
Accepts Healthy Volunteers
Subject must be at least 65 Years old.
Subject must be at most 79 Years

Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Contradiction
Clinical trial: RCT: WLE vs. NBI in Upper Gastrointestinal Endoscopy (NCT01945177)

Eligibility criteria:
Inclusion Criteria:

          1. Subjects aged > 50 years undergoing diagnostic or screening upper GI endoscopy

          2. ability to provide a written consent to trial participation.

        Exclusion Criteria:

          1. presence of active gastrointestinal bleeding

          2. presence of coagulopathy precluding biopsies

          3. absence of informed consent.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 50 Years old.


Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Efficacy Study of AGSPT201 Tablet to Treat Gastroesophageal Reflux Disease (NCT01400945)

Eligibility criteria:
Inclusion Criteria:

          -  aged 18~75 years

          -  Patients whose esophageal lesions graded over LA A grade (The severity of lesions is
             classified by LA classification)

          -  Patients whose typical reflux symptoms such as heartburn, acid regurgitation, acid
             reflux and esophagus irritation during the past 3 month

          -  Symptoms on at least 2 days of the past 7 days

        Exclusion Criteria:

          -  PPI treatment within 4 weeks before dosing or treatment of H2 blocker, sucralfate,
             prokinase NSAID (except low dose aspirin) within 2 weeks before dosing.

          -  Patients whose history of GI tract resection or vagotomy.

          -  Barrett's oesophagus greater than 3cm in length and high-grade dysplasia.

          -  Acid irrelevant Heartburn and regurgitation.

          -  Zollinger Ellison syndrome

          -  Hypersensitive and/or allergy to Pantoprazole and/or other PPI

          -  Pregnancy and lactation

          -  peptic ulcer

          -  serious hepatic

          -  any other renal, cardiac or haematological disease.

          -  Patients participated any other clinical studies during the past 3 months.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Contradiction
Clinical trial: Assessment and Treatment of Patients With Long-term Dizziness in Primary Care (NCT02655575)

Eligibility criteria:
Inclusion Criteria:

          -  The dizziness is provoked or aggravated by head movements, more than 3 months duration
             og symptoms, the dizziness started acute, understand Norwegian

        Exclusion Criteria:

          -  Dizziness no longer a problem, other known reasons, than vestibular, for the dizziness
             (neurological, psychological, or cancer), fluctuating vestibular disease (e.g,
             ménierès disease), scheduled for treatment of/ have had treatment for benign
             paroxysmal positional vertigo within one month,conditions where fast head movements
             are contraindicated (e.g. osteoporisis of the neck, whiplash associated injuries),
             participated in group therapy for dizziness within the past year, unable to attend
             test and treatment locations
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 70 Years

Patient description (medical language): A 47-year-old woman comes to the clinic complaining of dizziness.  She also has occasional nausea and ringing in her right ear.  The patient also has difficulty hearing while holding her phone to the left ear, although hearing in her right ear is normal.  The dizziness improves spontaneously, and she feels fine between episodes.  Past medical history is notable for hypothyroidism and low vit D level, for which she is using Levothyroxine and Vit D pearl.  She does not use tobacco or drink alcohol. Physical examination shows sensorineural hearing loss in the left ear. She has only one-man sexual partner and menopaused 2 years ago.

Patient description (patient's own words): The other day, I had to go to the clinic due to severe dizziness. I'm 47 years old, and I've been suffering from nausea and ringing in my right ear. I also have difficulty hearing in my left ear while I hold my phone, even if my hearing in my right ear is normal. The dizziness just gets me all of a sudden but I don't have any symptoms in between 2 episodes. I suffer from hypothyroidism and low vitamin D levels. So I take Levothyrox and vitamin D pearl. I don't smoke or drink. They conducted a physical exam and said I had hearing loss in my left ear. My only partner is my husband, and I'm menopause for 2 years now.

Does the patient match the trial criteria? Contradiction
Clinical trial: STI/HIV Prevention Intervention for Adolescents in Singapore (NCT02461940)

Eligibility criteria:
Inclusion Criteria:

          -  Singaporean citizens or permanent residents

          -  Sexually active for the past 1 year

          -  Heterosexual

          -  Attending the clinic for the first time

          -  Able to commit for one year in Singapore

        Exclusion Criteria:

          -  Involved in criminal investigation
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 16 Years old.
Subject must be at most 19 Years

Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Entailment
Clinical trial: Cardiomyopathy in DMD: Lisinopril vs. Losartan (NCT01982695)

Eligibility criteria:
Inclusion Criteria:

          -  Duchenne muscular dystrophy patients of all ages

          -  Null mutation of the dystrophin gene or muscle with <5% dystrophin

          -  Doppler echocardiogram with ejection fraction (EF) <55% within 30 days of enrollment

          -  Ability to cooperate for testing

          -  Glucocorticoid treatment acceptable including daily or weekend administration of
             prednisone or deflazacort

        Exclusion Criteria:

          -  Patients with EF 55% or greater

          -  Patients with EF <40% after washout

          -  Patients taking >5 mg lisinopril, or >25 mg losartan or >5 mg enalapril

          -  Skeletal deformities or pulmonary anatomical variants that preclude consistent
             measures of Doppler echocardiography
Male
No healthy subjects accepted to join the trial.



Patient description (medical language): An 8-year-old boy is brought to the clinic by his parents because of weakness and difficulty of standing up from a sitting position. The mother is healthy but had a brother who died in his 20th after being disabled and using wheelchairs in the last few years of his life. Physical examination shows 3/5 lower extremity muscle strength and enlarged calf muscles. The other physical examination and vital signs are unremarkable. Muscle biopsy showed absence of dystrophin protein. The patient is diagnosed with DMD.

Patient description (patient's own words): I brought my  8-year-old son to the doctor's clinic. He was struggling to stand up from a chair for the past few days. My wife is healthy but she was pretty worried since his brother died in his 20s after being disabled and using a wheelchair for the last years of his life. The doctor did an exam which highlighted weakness in the leg muscles and unusually large calf muscles. The rest of the exam was fine, and his vitals were normal. My son did a muscle biopsy, and it showed that the protein important for muscle strength and function is missing. The doctor diagnosed him with Duchenne muscular dystrophy.

Does the patient match the trial criteria? Contradiction
Clinical trial: The Effect of Lactobacillus Reuteri ATCC PTA 6475 on Volumetric Bone Mineral Density in Patients With Osteopenia (NCT02422082)

Eligibility criteria:
Inclusion Criteria:

          -  bone mineral density T-score less than -1 but more than -2.5 in the total hip or
             femoral neck or lumbar spine (L1-L4) by dual energy x-ray absorptiometry

          -  signed informed consent

          -  stated availability throughout the entire study period

          -  mental ability to understand and willingness to fulfill all the details of the
             protocol

        Exclusion Criteria:

          -  untreated hyperthyroidism

          -  rheumatoid arthritis

          -  diagnosed with disease causing secondary osteoporosis within the last year, including
             primary hyperparathyroidism, chronic obstructive pulmonary disease, inflammatory bowel
             disease, celiac disease, or diabetes

          -  recently diagnosed malignancy (within the last 5 years)

          -  per oral corticosteroid use

          -  use of antiresorptive therapy, including systemic hormone replacement therapy,
             bisphosphonates, strontium ran elate

          -  use of teriparatide (current or during the last 3 years)

          -  participation in other clinical interventional trials

          -  use of antibiotics within 2 months preceding the inclusion
Female
Accepts Healthy Volunteers
Subject must be at least 75 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 55-year-old white woman comes for a routine checkup.  She has no significant medical history and does not use tobacco, alcohol, or illicit drugs.  The patient's only medication is an over-the-counter multivitamin.  Family history is notable for a hip fracture in her mother.  Blood pressure is 130/80 mm Hg and pulse is 112/min. She has occasional back pain and lives a sedentary lifestyle with the BMI of 24 Kg/m2. Plain X-ray of the spine shows mild compression fracture at the level of T10. X-ray absorptiometry studies demonstrate abnormally low bone density in the lumbar vertebrae and T-score values below -2.5, which confirms the diagnosis of osteoporosis.

Patient description (patient's own words): I'm a 55-year-old white woman and I recently visited my family doctor. I don't smoke anything or drink. I don't have any remarkable medical history. I only use over-the-counter multivitamins to keep myself fresh and energized. My mom had a hip fracture. The doctor took my blood pressure and it was 130/80 and my pulse was 112/min. I have annoying back pain from time to time and to be honest I don't exercise much or move much. My BMI is 24. I did a spine X-ray a while ago and my doctor showed me that I have a fracture on one of my vertebrae. I also have a low bone density in my lumbar vertebrae and T-score values below -2.5. The doctor diagnosed me with osteoporosis.

Does the patient match the trial criteria? Contradiction
Clinical trial: AGN-199201 for the Treatment of Erythema With Rosacea (NCT01735201)

Eligibility criteria:
Inclusion Criteria:

          -  Redness of the skin caused by rosacea

        Exclusion Criteria:

          -  ≥3 inflammatory lesions

          -  Laser light-source or other energy based therapy in the last 6 months

          -  Any prescription or over the counter product for the treatment of acne or rosacea in
             the last 14 days
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment