araag2/NLI4PR huggingface dataset:
Clinical trial: Extreme Lipids Repository (NCT04156997)

Eligibility criteria:
Inclusion Criteria:

          -  adult patients (age 18 years or older) diagnosed with any lipid or metabolic disorder
             including hyperlipidemia, dyslipidemia, hyperlipoproteinemia, low HDL levels and
             deranged lipoprotein metabolism

        Exclusion Criteria:

          -  Anyone under 18 years of age will be excluded from the study.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Entailment
Clinical trial: Patient Education Program for Osteoarthritis With Exercise Included (NCT01119547)

Eligibility criteria:
Inclusion Criteria:

          -  Clinical diagnosis of osteoarthritis

        Exclusion Criteria:

          -  Must be able to speak and understand swedish
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.



Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment
Clinical trial: Periodontal Status in Oral Lichen Planus Patients (NCT04259034)

Eligibility criteria:
Inclusion Criteria:

        Individuals aged 40-50 yrs. Clinically diagnosed and histo-pathologically confirmed cases
        of oral Lichen Planus

        Exclusion Criteria:

        History of periodontal therapy in last one year. Drug-induced lichenoid reaction or any
        other red or white lesions in the oral cavity.

        The presence of any tooth restoration near the lesions. Smokers or patients with history of
        smoking. systemic diseases or conditions that are reported to be associated with
        periodontal diseases, including diabetes mellitus, osteoporosis, rheumatoid arthritis
        Pregnant and lactating women. Patients with history of systemic treatment for oral Lichen
        Planus Patients with cutaneous lichen planus
No condition on gender to be admitted to the trial.

Subject must be at least 40 Years old.
Subject must be at most 50 Years

Patient description (medical language): A 27-year-old woman comes to the dermatology clinic with skin rash and oral ulcers.  The rashes are mildly itchy. The patient has no other medical conditions and takes no medications.  Vital signs are normal.  On examination, there are pink papules symmetrically distributed over the anterior surfaces of the shins and ankles. There are some white ulcerated papules on her buccal mucosa. She is in relationship with her boyfriend and has only one sexual partner. Her boyfriend uses condoms. She smokes 1 to 2 cigarettes a day and drinks a beer daily. Biopsy reveals prominent hyperkeratosis with a thickened granular layer.  There is an infiltration of mononuclear cells in the superficial dermis that involves the overlying epidermis. The rete ridges have a sawtooth appearance.

Patient description (patient's own words): I went to the dermatologist because I had rashes on my skin and ulcers in my mouth. The rashes were not that itchy. I don't get it! I'm 27, I don't take medication, nor I don't have any other illnesses. My vitals were normal. My doc told me there were pink spots on the back of my throat. I'm heterosexual and have been only with my boyfriend and he uses condoms. I smoke 1 or 2 cigarettes a day and I drink a beer to accompany it. I had a biopsy and it showed some thick and grainy skin texture. The doc said it's an immune reaction.

Does the patient match the trial criteria? Contradiction
Clinical trial: A Study of Efficacy and Safety With the Transdermal Contraceptive System. (NCT00236769)

Eligibility criteria:
Inclusion Criteria:

          -  Healthy women with regular menstrual cycles

          -  sexually active and at risk of pregnancy

          -  nonpregnant

          -  acceptable body mass index (BMI)

          -  last term pregnancy at least 42 days prior, nonlactating, with 1 normal menstrual
             cycle since

          -  sitting BP<140mmHg/<90mmHg

          -  1 normal menstrual cycle since removal of IUD or norplant

          -  agreement to use study drug for contraception for up to 13 cycles, except when backup
             contraception is required for disease protection or patch detachment

          -  agree not to use other systemic steroid medication

        Exclusion Criteria:

          -  Presence, history, hereditary predisposition or risk of deep vein thrombophlebitis or
             thromboembolic disorders

          -  cerebral vascular or coronary artery disease, hypertension, or severe migraines

          -  liver tumor resulting from estrogen-containing products

          -  diabetes mellitus

          -  cholestatic jaundice, liver or renal disease

          -  abnormal PAP smear

          -  thyroid disorder

          -  dermal hypersensitivity

          -  carcinoma of breast, endometrium or other estrogen-dependent neoplasia

          -  substance abuse

          -  received experimental drug within prior 30 days

          -  smoking women over 35 years of age.
Female
Accepts Healthy Volunteers
Subject must be at least 18 Years old.
Subject must be at most 45 Years

Patient description (medical language): A 43-year-old woman, gravida 3 para 3, comes to the clinic complaining of recently painful menstrual cycles.  The patient's last menstrual period was 2 weeks ago. Urine β-hCG is negative. Menarche was at age 12, and menstrual periods occur every 28 days and lasts for 5 days.  She is sexually active with her husband and does not have pain with intercourse. BMI is 23 kg/m2 and Vital signs are normal.  On physical examination, the uterus is uniformly enlarged and tender. She is candidate for hysterectomy with the diagnosis of adenomyosis.

Patient description (patient's own words): I'm 43, and I paid a visit to my doctor because my last few periods were insanely painful. My last periods were 2 weeks ago. I already had three pregnancies that gave me the three lovely children. I did a urine test to check for potential pregnancy, and it came back negative. I started to have my periods at the age of 12, and I have been pretty regular with periods every 28 days for 5 days. I'm sexually active with my husband and I do not have any pain when we have sex. My BMI is 23 and my vitals were normal. The doctor performed a physical exam and found that my uterus was tender and enlarged. She proposed me a hysterectomy and diagnosed me with adenomyosis.

Does the patient match the trial criteria? Entailment
Clinical trial: A Comparison of the Efficacy and Safety of Topiramate Versus Placebo in Treating Tremor of Unknown Cause. (NCT00236496)

Eligibility criteria:
Inclusion Criteria:

          -  Current symptoms of essential tremor based on the Tremor Investigational Group (TRIG)
             criteria

          -  Dominant upper extremity posture or action intention tremor of 2 (moderate) to 4
             (severe)

          -  In good health otherwise

        Exclusion Criteria:

          -  Patients with abnormal neurologic signs other than essential tremor

          -  Taking more than one anti-tremor medication

          -  Taking drugs known to cause tremors

          -  With physical damage to the nervous system or Parkinson's disease

          -  Known to be abusing drugs or alcohol

          -  Women who are pregnant or breast-feeding
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 60-year-old man comes to the clinic complaining of hand tremor that started few months ago.  It is most bothering when he wants to drink from a glass or pour from a bottle. He does not smoke, but drinks occasionally. He recently started consuming more alcohol as his tremor subsides somewhat when he drinks small amounts of alcohol.  Family history is significant for similar problems in his mother.  Vital signs are normal and the patient has no other medical conditions.  Neurologic examination shows bilateral tremor in the upper extremities. The diagnosis of essential tremor is confirmed.

Patient description (patient's own words): I'm only a 60 years old man but I already suffer from shaky hands. It started a few months ago, and it really bothers me when I want to pour myself a glass or even while drinking. I don't smoke, but I drink alcohol from time to time. To be honest, I've been drinking a little more lately since it helps me with the shaking. My mom had the same issue when she was my age. The doctor took my vitals, and they were normal. I don't have any other medical issues. I underwent neurological exams and it showed that I’m shaky from both sides. The doctor diagnosed me with essential tremor.

Does the patient match the trial criteria? Entailment
Clinical trial: Magnetic Resonance Imaging Evaluation of Inner Ear Pathology Using Intra-Tympanic Contrast Agent (NCT02080312)

Eligibility criteria:
Inclusion Criteria:

          -  Symptoms and clinical exam consistent with Ménière's disease

          -  Ability to undergo MR exam

          -  Interest in participating in this study

          -  Ability to provide informed consent

        Exclusion Criteria:

          -  Children (under age 18),

          -  Contraindication to MR imaging (see attached UCSD MR Screening Form)

          -  Claustrophobia precluding MR exam without sedation

          -  Contraindication to receiving intravenous gadolinium-based contrast agent (see
             attached UCSD Contrast Policy)

          -  Patients who are pregnant or breast feeding (intravenous contrast agents are Category
             C)

          -  Contraindication to osmotic challenge (congestive heart failure, renal failure,
             hepatic failure)
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 50-year-old woman comes to the clinic with intermittent ear discharge and sense of hearing loss on her left ear.  Past medical history is significant for obesity, hyperlipidemia, and diabetes mellitus.  Her medications include Metformin, Atorvastatin and Vit D supplement. Vital signs are normal. BMI is 37. Otoscopy shows a small perforation in the left tympanic membrane and a pearly mass behind the membrane.  Conduction hearing loss is noted in the left ear.  The remainder of the ear, nose, and throat examination is normal.

Patient description (patient's own words): I went to the clinic the other day because I had some fluid in my ear and I felt like I could not hear as well as I used to in my left ear. I'm a 50-year-old woman, and I have been obese for a while now. I have diabetes and cholesterol. I take some medication. I take metformin, atorvastatin, and vitamin D supplements. When I was admitted, my vitals were normal. My BMI is 37. When they looked into my ears, they said that my left tympanic membrane was broken and there was some fluid behind the membrane. During the hearing test, they could assess that my left ear suffers from hearing loss. They also performed ear, nose, and throat examinations that turned out to be normal.

Does the patient match the trial criteria? Contradiction
Clinical trial: Validation of the DyCare® Lynx System for Motion Analysis of the Wrist (NCT04773535)

Eligibility criteria:
Inclusion Criteria:

          -  10 test persons with healthy right-dominant hands

          -  Test Persons older than 18 Years

          -  Test persons willing and able to give written informed consent to participate in the
             study

        Exclusion Criteria:

          -  Inflammatory disease (e.g. rheumatoid arthritis)

          -  German language barrier to understand instructions

          -  Any disease process that would preclude accurate evaluation (e.g. neuromuscular,
             psychiatric or metabolic disorder)

          -  Legal incompetence

          -  Participation in any other medical device or medicinal product study within the
             previous months that could influence the results of the present study
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 18 Years old.


Patient description (medical language): A 19-year-old girl comes to the clinic due to a left wrist mass.  She noticed swelling on the top of her wrist about 4 months ago and came to the clinic due to cosmetic concerns.  Examination shows a nontender, rounded mass on the dorsal wrist that transilluminates with a penlight. Vital signs are normal. The patient needs to type on her computer almost all day. She is left-handed. She does not smoke or use illicit drugs. She is in sexual relationship with two male partners and uses condoms.

Patient description (patient's own words): I'm a 19-year-old girl and I went to see my doctor because of a mass on my left wrist. I noticed a swelling on top of my wrist, like 4 months ago, and I went the first time to the doctor because it was pretty ugly! My wrist was not tender, and the mass was round and let the light go through when the doctor used a penlight. My blood pressure, breathing and temperature were normal. I'm left-handed and I need to be on my PC all day. I don't smoke or do drugs. I'm sexually active and I have 2 male partners but they all use condoms.

Does the patient match the trial criteria? Contradiction
Clinical trial: Ultrasound-Guided Pulsed Radiofrequency In The Treatment Of Patients With Osteoarthritis Knee (USPRFGENOAK) (NCT02915120)

Eligibility criteria:
Inclusion Criteria:

          -  Chronic knee pain with pain intensity of at least 4 out 10 on the VAS on most or all
             days for more than 3 months

          -  Patients of either sex with primary osteoarthritis of one or both knees fulfilling
             diagnostic criteria for osteoarthritis knee laid down by American College of
             Rheumatology.

          -  Patients also had to have a Kellgren-Lawrence (radiologic criterion) score of at least
             2

          -  Pain resistant to conventional therapy including NSAIDs, opioids, muscle relaxants,
             oral steroids, physical therapy, and intra-articular injection therapy.

        Exclusion Criteria:

          -  The patients with secondary osteoarthritis of knees

          -  Associated systemic arthropathies, e.g. rheumatoid arthritis and gout

          -  Previous radiofrequency ablation treatment for similar symptoms.

          -  Intra-articular knee corticosteroid or hyaluronic acid injection in the past 3 months.

          -  Active systemic or local infections at the site of proposed needle and electrode
             placement.

          -  Coagulopathy or other bleeding disorder

          -  Cognitive deficit.

          -  Unstable medical or psychiatric illness.

          -  Previous knee joint replacement surgery

          -  Patients missing two or more appointments consecutively were excluded from the study
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 40 Years old.


Patient description (medical language): A 47-year-old woman comes to the office complaining of pain in the calf and knee when she bends down. The pain limits her activity. Her medical history is significant for osteoarthritis, for which she uses nonsteroidal anti-inflammatory drugs (NSAIDs) for the past two years. She is living with her husband and has 3 children. She doesn't smoke but drinks alcohol occasionally. Her vital signs are normal. On physical examination, there is a small effusion in the right knee. The effusion grew a little larger and she developed a tender swelling in the popliteal fossa and calf. Both the pain and swelling worsened as she bent and straightened her knee.

Patient description (patient's own words): I'm a 47-year-old woman, married with 3 kids. I don't smoke and I drink occasionally. I went to the doctor because of pain in my calf and knee when I was bending down. This has been limiting my daily activities. I have been diagnosed with osteoarthritis for which I have taken anti-inflammatory drugs for the past 2 years. The doctor saw a small fluid buildup in my right knee. This buildup became a bit bigger and I have a swollen calf. The pain is worse when I bend and straighten my knee.

Does the patient match the trial criteria? Entailment
Clinical trial: Pacemaker Therapy for Drug-refractory Symptoms in Mid-cavity Hypertrophic Cardiomyopathy (NCT03450252)

Eligibility criteria:
Inclusion Criteria:

          1. Male or female, >18 years.

          2. Referred for PPM +/- ICD implantation for either primary prevention of sudden cardiac
             death or other indications such as heart block or obstructive physiology.

          3. HCM patients with a mid-cavity gradient of ≥30 mmHg demonstrated by echocardiography
             and gradient confirmed by cardiac catheterisation at rest or with isoprenaline
             provocation. HCM morphology confirmed by cardiac MRI.

          4. All patients should be taking maximum tolerated doses of beta blockers or verapamil
             with or without disopyramide.

          5. Symptoms refractory to optimum medical therapy as above, for example breathlessness,
             chest pain, dizziness, or syncope.

        Exclusion Criteria:

          1. Patients with multi-level obstruction, i.e. across the mid-cavity and outflow tract.

          2. Patients with moderate or severe valvular stenosis or regurgitation.

          3. Patients with a history of myocardial infarction or acute coronary syndrome.

          4. Patients unable to provide informed consent.

          5. Patients in atrial fibrillation.

          6. Pregnancy.

          7. Renal failure.

          8. If considered unsuitable by clinician.

          9. Patients already participating in trials involving invasive procedures.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 23-year-old man comes to the emergency department following an episode of syncope.  He was working out when he felt dizzy and passed out without head injury.  He has had 3 other episodes of light-headedness over the last year, all happening during physical activity. He never had this experience while resting. He has no other medical conditions.  The patient does not use tobacco, alcohol, or illicit drugs.  His father died suddenly at age 35.  Vital signs are within normal limits.  On physical examination, the patient has a harsh systolic murmur.  The lungs are clear with no peripheral edema. Echocardiography shows asymmetric interventricular septal hypertrophy.

Patient description (patient's own words): I'm 23, and I got admitted to the ER because I fainted all of a sudden. I was in the gym, working out, when all of a sudden, I just got dizzy and passed out. Hopefully, I didn't hit my head. It's not my first time having that kind of dizziness at the gym, never when I'm chilling at home tho. I don't have any special medical conditions and I'm not even smoking, drinking or doing drugs! My dad died suddenly when he was 35, so I'm kind of scared. My vitals were normal while at the ER and they did a physical exam and they told me my heart sounds abnormal. My lungs are ok, but I had to do an echography of my heart, and they told me it is bigger than average.

Does the patient match the trial criteria? Entailment