Clinical trial: Application Value of CTCs Detection for Advanced Gastric Cancer Patients (NCT03156777)

Eligibility criteria:
Inclusion Criteria:

        Subjects eligible for enrollment must meet all of the following criteria:

          1. Provide signed informed consent. The subject is capable of understanding and complying
             with parameters as outlined in the protocol and able to sign informed consent,
             approved by the Independent Ethic Committee (IEC)/Institutional Review Board (IRB)
             prior to the initiation of any study-specific procedures

          2. Men or women aged >= 18 years and <=75 years.

          3. Eastern Cooperative Oncology Group Performance Status (ECOG) <= 2.

          4. Histologically confirmed adenocarcinoma of the stomach, gastroesophageal junction.

          5. Metastatic disease or locally advanced disease not amenable to curative surgery.

          6. Radiographically assessable, non-measurable disease or measurable disease as per
             RECIST criteria.

          7. Life expectancy of at least 12 weeks with tumor and at least 5 years without tumor
             from the time of enrollment.

          8. No other malignancy within the past 5 years except adequately treated basal cell or
             squamous cell skin cancer or carcinoma in situ of the cervix.

          9. No prior chemotherapy for advanced disease. -

        Exclusion Criteria:

        Subjects meeting any of the following criteria must not be enrolled in the study:

          1. Gastric carcinoid, sarcomas, or squamous cell cancer.

          2. Pregnant or lactating females.

          3. Significant neurological or psychiatric disorders (psychotic disorders, dementia or
             seizures) that would prohibit the understanding and giving of informed consent.

          4. Active Hepatitis B or C or history of an HIV infection.

          5. Active uncontrolled infection. -
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 75 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction