araag2/NLI4PR huggingface dataset:
Clinical trial: Phase 3 Papulopustular Rosacea Study (NCT01493687)

Eligibility criteria:
Inclusion Criteria:

          1. The subject has papulopustular rosacea with an Investigator Global Assessment (IGA)
             score rated 3 (moderate) or 4 (severe),

          2. The subject has at least 15 but not more than 70 inflammatory lesions (papules and
             pustules) on the face.

        Exclusion Criteria:

          1. The subject has particular forms of rosacea (rosacea conglobata, rosacea fulminans,
             isolated rhinophyma, isolated pustulosis of the chin) or other facial dermatoses that
             may be confounded with papulopustular rosacea, such as peri oral dermatitis, facial
             keratosis pilaris, seborrheic dermatitis, and acne,

          2. The subject has rosacea with more than two nodules on the face.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 41-year-old woman comes to the dermatology clinic complaining of facial redness, especially on her forehead and cheeks. She noticed that the redness gets worse in the summer and after sun exposure. She is otherwise healthy. On physical examination, she has multiple papules and pustules present on her forehead, cheeks, and nose on a background of erythema and telangiectasias. There are no other lesions or nodules. The patient is married and has 2 children who are 5 and 9 years old. She has IUD and doesn't wish to have more kids. She does not smoke or drink alcohol. Her vital signs are normal, and BMI is 21.

Patient description (patient's own words): I'm 41, married with 2 lovely kids who are 5 and 9 years old. I have an IUD and I don't want to have more kids. I don't smoke or drink alcohol. I had to go to the dermatology clinic because I had terrible redness on my face, especially on my forehead and cheeks. It got worse in the summer and after being under the sun. I'm usually healthy. They conducted a physical exam and they found several lesions and pustules on my forehead, cheeks and nose and they also found some signs of erythema and telangiectasia. My vitals were normal, and my BMI is 21.

Does the patient match the trial criteria? Entailment
Clinical trial: Serum VEGF as a Tubal Pregnancy Marker (NCT02973230)

Eligibility criteria:
Inclusion Criteria were:

          -  women that had a positive hCG test and presented with either abdominal pain or vaginal
             bleeding; all pregnancies were singletons, spontaneously conceived, with accurate
             assessments of their gestational age (42 - 56 days from the first day of the last
             menstrual period). A detailed informed consent was obtained from each patient before
             the inclusion.

        Exclusion Criteria was:

          -  non-ampullar tubal pregnancy (surgically confirmed).
Female
No healthy subjects accepted to join the trial.



Patient description (medical language): A 32-year-old woman comes to the hospital with vaginal spotting.  Her last menstrual period was 10 weeks ago. She has regular menses lasting for 6 days and repeating every 29 days. Medical history is significant for appendectomy and several complicated UTIs. She has multiple male partners, and she is inconsistent with using barrier contraceptives. Vital signs are normal.  Serum β-hCG level is 1800 mIU/mL, and a repeat level after 2 days shows an abnormal rise to 2100 mIU/mL.  Pelvic ultrasound reveals a thin endometrium with no gestational sac in the uterus.

Patient description (patient's own words): I just turned 32 and last morning I woke up with strange blood stains on my underwear. My last periods were more than 2 months ago, which is unusual for me because I used to have regular periods lasting for 6 days every 29 days, more or less. I had several UTIs in the past. I also had appendicitis. I'm currently seeing several men and, to be honest, some of them do struggle to wear a condom. I went to the hospital to check myself up and they told me that my vitals were normal. I also had a blood test on Monday, and my β-hCG level was 1800 mIU/mL, and then on Wednesday, it went up to 2100 mIU/mL. The gynecologist also did an ultrasound and she told me that, hopefully, there was no ovule.

Does the patient match the trial criteria? Entailment
Clinical trial: A Trial on Probiotics in Preventing Hirschsprung's Disease Associated Entercolitis (NCT01934959)

Eligibility criteria:
Inclusion Criteria:

        The inclusion criteria consists of all patients suffering from HD at an age of less than 13
        years old, and HD is confirmed by postoperative pathological examination, barium enema and
        anorectal manometry.

        Exclusion Criteria:

          -  Age> 13 years old

          -  Patients are complicated with mental, neurological disorders (such as hypoxic-ischemic
             encephalopathy, epilepsy and dementia) or can not thrive.

          -  Patients are complicated with congenital gastrointestinal malformations (such as anal
             stenosis, intestinal atresia stenosis), metabolic and endocrine diseases caused by
             organic constipation and functional constipation in children.

          -  Children are complicated with liver, kidney dysfunction, blood disorders, immune
             deficiency diseases and significant ECG abnormalities.

          -  Children have taken oral antibiotics, microecological modulator, yogurt, other
             gastrointestinal motility drugs which can affect the gut flora.

          -  Drug allergies, or allergic diseases..

          -  Poor compliance with oral probiotics treatment.
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 1 Month old.
Subject must be at most 13 Years

Patient description (medical language): A 7-month-old boy is brought to emergency by his parents due to irritability and inability to defecate for the past 3 days.  The patient has had constipation and discomfort with bowel movements since birth.  His symptoms worsened after eating semi-solid foods.  Vital signs are normal.  Abdominal examination shows distension and tenderness to palpation with presence of bowel sounds.  Xray with barium shows a narrow rectum and rectosigmoid area.  The rest of the colon proximal to this segment is dilated. Digital rectal exam revealed burst of feces out of the anus. The biopsy showed absence of submucosal ganglia in the last segment of the large intestine.

Patient description (patient's own words): My baby boy just turned 7 months old but my wife and I cannot get a hold of him! He has not been able to poop for 3 days! My poor little thing has been having constipation and bowel problems since birth. But since he ate some semi-solid food it has just been worse! The doctor said his vitals are normal but his belly is tense and tender with his bowels making noise. They did an X-ray and found out that he had a narrow rectum. His colon is dilated. They also performed a touch rectal exam and he could finally poop! The biopsy revealed that there is no submucosal ganglia in his large intestine.

Does the patient match the trial criteria? Entailment
Clinical trial: Biomarker Study for Alzheimer's Disease (NCT02472899)

Eligibility criteria:
Inclusion Criteria:

          -  Dementia syndrome resulting from probable Alzheimer's disease

        Exclusion Criteria:

          -  Dementia syndrome caused by conditions other than Alzheimer's disease
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 60 Years old.


Patient description (medical language): A 70-year-old man comes to the office accompanied by his wife.  The patient has experienced progressive memory loss over the last years.  He needs help with some of his routine activities, such as paying bills.  The patient's wife says, "He used to be such an independent person, but now he needs help with many things, even finding direction to home!"  Medical history includes hypertension, hyperlipidemia, and type 2 diabetes mellitus.  Family history includes Alzheimer disease in his father.  MRI reveals diffuse cortical and hippocampal atrophy. The diagnosis of AD is made using the National Institute on Aging and the Alzheimer's Association (NIA-AA) criteria.

Patient description (patient's own words): I am a 70-year-old man, and I paid a visit to the doctor with my wife the other day. I noticed that I tend to forget small things and that my memory has decreased over the past few years. I even ask my wife to help me out with my daily routine. I used to be the one paying the bills, but now she has to give me a hand. My wife mentioned to the doctor that I used to be independent and that I tend to forget where we live. I suffer from hypertension, high cholesterol, and type 2 diabetes. My poor dad was suffering from Alzheimer disease, so I hope I'm not going to end the same way! I did an MRI and they found out that some part of my brain was decreasing. I also did an Alzheimer test.

Does the patient match the trial criteria? Entailment
Clinical trial: Lansoprazole Versus Mosapride for Functional Dyspepsia (NCT00663897)

Eligibility criteria:
Inclusion Criteria:

          -  aged more than 20 years old

          -  diagnosis of functional dyspepsia by fulfilling Rome-III criteria

          -  outpatient

        Exclusion Criteria:

          -  aged less than 20 years

          -  organic lesions including ulcers, tumors, bleeding, vasculopathy or esophagitis as
             demonstrated on upper endoscopy

          -  concurrent illness with malignancy, diabetes mellitus, liver cirrhosis, renal failure
             or porphyria

          -  diagnosis of organic disease for dyspeptic symptoms by treating physicians

          -  history of abdominal surgery

          -  concurrent user of aspirin and NSAID

          -  history of allergy or severe side effects to lansoprazole or mosapride

          -  pregnant or lactating women
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 20 Years old.
Subject must be at most 90 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Contradiction
Clinical trial: Aromatase Inhibitor Growth Study: Letrozole vs. Anastrozole (NCT02137538)

Eligibility criteria:
Inclusion Criteria:

          -  Current height less than 5th percentile AND/OR

          -  Predicted adult height (based on bone age) more than 10 cm below target height (mid
             parental height)

          -  Evidence of puberty: physical signs and serum luteinizing hormone > 0.3 IU/L and
             testosterone > 15 ng/dl

        Exclusion Criteria:

          -  Bone age reading more than 14.0 years

          -  Follicle stimulating hormone > 20 IU/L
Male
No healthy subjects accepted to join the trial.
Subject must be at least 10 Years old.
Subject must be at most 17 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Endoscopy With Short Fasting (NCT01492296)

Eligibility criteria:
Inclusion Criteria:

          -  elective endoscopy

        Exclusion Criteria:

          -  poor clinical condition
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 63-year-old man comes to the clinic for recent unintentional weight loss. The patient also has epigastric discomfort after meals. He has no known medical problems and takes no medications. His blood pressure is 130/75 and pulse rate is 88/min. He is not febrile. Upper endoscopy shows a lesion in the stomach that shows typical features of diffuse-type adenocarcinoma presenting with signet ring cells that do not form glands.

Patient description (patient's own words): I went to the clinic because I had been losing so much weight that it was concerning. I'm a 63-year-old guy, and it is something rather unusual. I'm always suffering from stomachache after every meal. I've never been sick, and I don't take any medicine. The doctor took my blood pressure and told me it was 130/75, and my pulse rate was 88/min. I'm not febrile! I also had to do an endoscopy, and they found a lesion in my stomach that shows typical features of stomach cancer. I'm totally devastated...

Does the patient match the trial criteria? Entailment
Clinical trial: Diagnostic Yield of Post PRandial Esophageal High Resolution Impedance Manometry in Patients With Gastro-Esophageal Reflux Disease Symptoms Resistant to Proton Pump Inhibitor Therapy (NCT03596476)

Eligibility criteria:
Inclusion Criteria:

          -  Patient older than 18 years

          -  Typical symptoms of GERD (heartburn, regurgitation) at least twice a week despite PPI
             therapy for at least one month.

          -  Reflux Disease Questionnaire (RDQ) score off PPI > 3

          -  Subject with health insurance

        Exclusion Criteria:

          -  Previous esophago-gastric surgery,

          -  Previous history of developing esophageal or gastric tumor, esophageal stricture, or
             esophageal varices

          -  Pregnancy (assessment at V0)

          -  Contraindication to general anesthesia,

          -  Contraindications to the wireless capsule pH-monitoring: pacemakers, implantable
             cardiac defibrillator,

          -  Contraindications to HRIM: inability to tolerate nasal intubation, significant
             bleeding disorders for which nasal intubation is contraindicated, known esophageal
             obstruction is preventing the passage of the HRIM probe.

          -  Intolerance or allergy to one component of the test meal,

          -  Intolerance or allergy to PPI,

          -  Inability to give consent,

          -  Mentally unbalanced patients, under supervision or guardianship

          -  Decline to participate in the study,

          -  Participation in another study at the same time
No condition on gender to be admitted to the trial.
No healthy subjects accepted to join the trial.
Subject must be at least 18 Years old.


Patient description (medical language): A 48-year-old man comes to the office complaining of heartburn and acid reflux.  He has taken over-the-counter antacids but sees no relief.  Other medical history is unremarkable.  The patient does not use tobacco, alcohol, or illicit drugs.  Vital signs are within normal limits.  BMI is 31 kg/m2.  Physical examination is  positive for mild tenderness in upper stomach. Chest x-ray shows an air-fluid opacity behind the heart.  A barium swallow study reveals approximately 1/3 of the stomach herniating through the esophageal hiatus.

Patient description (patient's own words): I went to my doctor's office because of a non-stop heartburn and some acid reflux. I took over-the-counter medications, but it keeps going strong! I don't smoke, take drugs or drink alcohol, I'm healthy! The doctor took my vitals, which turned out normal. My BMI is 31, which might be a bit too much for a 48-year-old guy like me. They examined my stomach and found a mild tenderness in the upper part. I also did some X-rays, and they found out that I have an air-fluid opacity behind my heart. I did another X-ray, and it turns out that a part of my stomach went up my chest through a hole in my diaphragm!

Does the patient match the trial criteria? Entailment
Clinical trial: Weekly Zinc Chelate Supplementation on Children's Growth (NCT01911260)

Eligibility criteria:
Inclusion Criteria:

          -  Children with one and a half or more standard deviations below the mean height for age
             and gender of the reference population (Z-score under -1.6) were included in the
             Growth Deficit group (GD). For the Normal Stature group(NS), HAZ was set up as being
             between -1 and +1 standard deviations from the mean height reference for age and sex.

        Exclusion Criteria:

          -  Children of GD group were evaluated by a Pediatrician specialized in growth disorders
             with the objective of excluding any organic or genetic condition correlated with
             growth deficit.
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 7 Years old.
Subject must be at most 10 Years

Patient description (medical language): A 9-year-old girl is brought to the office for evaluation of short stature and overweight body habitus. The patient's mother and father are 170 cm and 181 cm tall, respectively.  On physical examination, the patient's height is in the 5th percentile of her age.  Other findings include low-set ears, a high arched palate, a webbed neck, and cubitus valgus.  Chromosomal analysis reveals a 45, XO karyotype.

Patient description (patient's own words): I took my 9-year-old daughter to the doctor because my mother-in-law kept saying she seemed small and overweight. My husband and I are 170 cm and 181 cm tall, respectively. The physical health highlighted that she is in the 5th percentile of her age. The doctor said that she has low-set ears, a high-arched palate, a webbed neck, and cubitus valgus. She also did a chromosomal analysis, which revealed a 45, XO karyotype.

Does the patient match the trial criteria? Contradiction
Clinical trial: Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis (NCT03628508)

Eligibility criteria:
Inclusion Criteria:

          1. Age between 50-80

          2. having radiographic tibiofemoral joint OA in the medial compartment defined as
             Kellgren and Lawrence grade = 2 to 3

          3. having medial knee pain on most days of the month

          4. having a minimum average pain score of 2 on an 11-point numerical rating scale in the
             past week while walking

        Exclusion Criteria:

          1. having lateral tibiofemoral compartment osteophytes greater than the medial side.

          2. having undergone intra-articular corticosteroid injection or knee surgery to either
             knee within the past 3 months

          3. having a systemic arthritic condition (e.g., rheumatoid arthritis)

          4. having a knee joint replacement or high tibial osteotomy in the past

          5. having any other muscular, joint or neurological condition influencing lower limb
             function

          6. unable to walk unaided

          7. having low back, hip, ankle or foot pain > 3 on numerical rating scale

          8. having a body mass index (BMI) >36 kg/ m2
No condition on gender to be admitted to the trial.
Accepts Healthy Volunteers
Subject must be at least 50 Years old.
Subject must be at most 80 Years

Patient description (medical language): A 66-year-old woman comes to the office due to joint pain in the hands and periodic morning stiffness that lasts less than 15 minutes.  The pain is moderately severe and worsens with daily activity. The patient used Tylenol with minimal relief.  Past medical history is notable for hypertension and hypercholesteremia.  Physical examination shows firm nodules over the distal interphalangeal joints, bilaterally. The patient has pain in her knees as well. The knees are stiff in the morning for less than 30 minutes and become worse with climbing stairs. She has some sensation of bone friction during activity. X-ray shows narrowing of the joint space, subchondral bone sclerosis and osteophyte formation along the joints.

Patient description (patient's own words): I'm a 66-year-old woman and I went to my doctor's office because of a bloody joint pain in my hands that has been lasting for a while. The pain comes and go in the morning usually. I feel like a stiffness that last less than 15 minutes. The pain is moderately severe but it gets worse when I'm using my hands. I used Tylenol which helped a little. Apart from that, I suffer from hypertension and high cholesterol. The doctor made me notice that I have bumps around both of my hand joints. I also suffer from my knees and they are also stiff in the morning for around 30 min. It's even worse when I climb up the stairs! I also feel like my bones are rubbing against each other when I'm moving. The X-ray showed that I have narrow joint space, I have sclerosis, and abnormal growths of bone along my joints.

Does the patient match the trial criteria? Entailment