Clinical trial NCT01342172 (phase 1/phase 2, status: terminated)
Conditions: urinary bladder neoplasms
ICD codes: D30.3, C67.5, C67.9, C79.11, C67.0, C67.1, D41.4
Drugs: lenalidomide
SMILES: NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O
Reason stopped: 
    low accrual
  
Eligibility criteria:

        Inclusion Criteria:

          1. Written informed consent and HIPAA authorization for release of personal health
             information. NOTE: HIPAA authorization may be included in the informed consent or
             obtained separately.

          2. Age > 18 years at the time of consent.

          3. Karnofsky Performance Status of ≥ 70%.

          4. Histological or cytological proof of transitional cell carcinoma of the urothelial
             tract. The primary site may include: urethra, bladder, ureters, and renal pelvis.
             Patients with mixed histologies may be enrolled provided that transitional cell
             carcinoma is the predominant histology.

          5. Measurable disease according to RECIST or unresectable disease (cT4b).

          6. All study participants must be registered into the mandatory RevAssist® program, and
             be willing and able to comply with the requirements of RevAssist®.

          7. Females of childbearing potential (FCBP)* must have a negative serum or urine
             pregnancy test with a sensitivity of at least 50 mIU/mL within 10 - 14 days and again
             within 24 hours prior to prescribing lenalidomide for Cycle 1 (prescriptions must be
             filled within 7 days) and must either commit to continued abstinence from heterosexual
             intercourse or begin TWO acceptable methods of birth control.

          8. Able to take aspirin (81 or 325 mg) daily as prophylactic anticoagulation (patients
             intolerant to ASA may use warfarin or low molecular weight heparin).

          9. Adequate organ function as determined by the following laboratory values:

               -  Hemoglobin (Hgb) > 9 g/dL

               -  Platelets > 100 x 1,000,000,000/L

               -  Absolute neutrophil count (ANC) > 1.5 x 1,000,000,000/L

               -  Calculated creatinine clearance of > 60 cc/min using the Cockcroft-Gault formula

               -  Bilirubin < 1.5 x ULN

               -  Aspartate aminotransferase (AST, SGOT) < 1.5 X ULN (< 5 X ULN if patient has
                  hepatic metastases)

        Exclusion Criteria:

          1. Has had prior treatment with systemic chemotherapy for metastatic disease (prior
             intravesical therapy is permitted; prior neoadjuvant/adjuvant chemotherapy permitted
             if completed ≥ 1 year from study entry)

          2. Has received prior lenalidomide.

          3. Has had major surgery within 30 days of starting the study treatment

          4. Has had any of the following within the 6 months prior to study drug administration:
             myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass
             graft, symptomatic congestive heart failure, cerebrovascular accident or transient
             ischemic attack, or pulmonary embolism

          5. Has active CNS metastases. Subjects with neurological symptoms must undergo a head CT
             scan or brain MRI to exclude brain metastasis.

          6. Has a history of a prior malignancy

          7. Has received anticancer therapy, radiation, or any investigational agent within 30
             days prior to being registered for protocol therapy.

          8. Pregnant or breastfeeding.

          9. Has a clinically significant infection as judged by the treating investigator.

         10. Known seropositive for or active viral infection with human immunodeficiency virus
             (HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV).