Clinical trial NCT00412412 (phase 1, status: completed)
Conditions: breast cancer
ICD codes: C79.81, D24.1, D24.2, D24.9, D49.3, C44.501, D48.60
Drugs: cnf2024, cnf2024 + trastuzumab
SMILES: COC1=C(C)C=NC(CN2C=NC3=C(Cl)NC(=N)N=C23)=C1C, COC1=C(C)C=NC(CN2C=NC3=C(Cl)NC(=N)N=C23)=C1C
Eligibility criteria:

        Inclusion Criteria (Group A):

          -  Age ≥18 years at the time of informed consent.

          -  Male and female subjects with confirmed HER2 adenocarcinoma of the breast with
             advanced disease (advanced disease will be defined as metastatic disease or locally
             advanced disease that is surgically unresectable and considered unmanageable with
             standard therapies such as radiation or systemic therapies) who have had disease
             progression on at least one standard hormonal or chemotherapy regimen for advanced
             breast cancer or who have refused standard therapies.

          -  Evaluable disease either by measurable disease (RECIST) or nonmeasurable disease.

          -  ECOG ≤2.

          -  Required Laboratory Values:ANC ≥1500 cells/mm3,platelet count ≥100,000
             cells/mm3,hemoglobin ≥9 gm/L; Glucose >3.3 mmol/L, sodium >130 mmol/L, calcium >2.0
             mmol/L.

          -  Plasma cortisol and ACTH levels that are not suggestive of adrenal insufficiency.

          -  Normal electrocardiogram (ECG) with QTc ≤450 msec for men and ≤470 msec for women.

          -  Female subjects of childbearing potential must have a negative pregnancy test within 7
             days prior to first study drug administration.

        Inclusion Criteria (Group B):

          -  Age ≥18 years at the time of informed consent.

          -  Male and female subjects with confirmed HER2+ (IHC 3+ or IHC 2+/FISH+) adenocarcinoma
             of the breast with advanced disease that have had disease progression on at least 1
             standard hormonal or chemotherapy regimen for advanced metastatic breast cancer.
             Advanced disease will be defined as metastatic disease or locally advanced disease
             that is surgically unresectable and considered unmanageable with standard therapies
             such as radiation or systemic therapies.

          -  Subjects must have progressed either within 3 months following last dose of adjuvant
             trastuzumab treatment or progressed following trastuzumab based therapies for
             metastatic disease.

          -  Measurable disease by RECIST or evaluable nonmeasurable disease

          -  ECOG ≤2.

          -  Required Laboratory Values: ANC ≥1500 cells/mm3,platelet count ≥100,000
             cells/mm3,hemoglobin ≥9 gm/L; Glucose >3.3 mmol/L, sodium >130 mmol/L, calcium >2.0
             mmol/L.

          -  Plasma cortisol and ACTH levels that are not suggestive of adrenal insufficiency.

          -  Normal ECG with QTc ≤450 msec for men and ≤470 msec for women.

          -  Female subjects of childbearing potential must have a negative pregnancy test within 7
             days prior to first study drug administration.

        Exclusion Criteria (Group A):

          -  Prior antitumor therapies including prior experimental agents or approved antitumor
             therapies, within 1 month.

          -  Active infection requiring intravenous (IV) antibiotic treatment.

          -  History of prior malignancies within the past 5 years with the exception of curatively
             treated basal or squamous cell carcinomas of the skin or carcinoma in situ of the
             cervix.

          -  Concurrent severe or uncontrolled diabetes and/or other medical disease

          -  Problems with swallowing or malabsorption.

          -  History of major surgery to small intestine.

          -  Prior treatment with Hsp90 inhibitors.

          -  History of central nervous system (CNS) metastasis.

        Exclusion Criteria (Group B):

          -  Prior antitumor therapies, including prior experimental agents or approved antitumor
             therapies, within 1 month.

          -  Active infection requiring intravenous (IV) antibiotic treatment.

          -  History of prior malignancies within the past 5 years with the exception of curatively
             treated basal or squamous cell carcinomas of the skin or carcinoma in situ of the
             cervix.

          -  Concurrent severe or uncontrolled diabetes and/or other medical disease

          -  Problems with swallowing or malabsorption.

          -  History of major surgery to small intestine.

          -  Cardiac left ventricular function with resting ejection fraction <50%, assessed by
             either ECHO or MUGA.

          -  Prior treatment with Hsp90 inhibitors.

          -  Diabetes treated with insulin.

          -  History of CNS metastasis.