Clinical trial NCT00077064 (phase 2, status: terminated)
Conditions: lung cancer, pulmonary complications, radiation fibrosis
ICD codes: C78.00, C78.01, C78.02, D14.30, D14.31, D14.32, C34.2, O89.09, O29.091, O29.092, O29.093, O29.099, O74.1, K62.7, G62.82, N46.024, N46.124, T66.XXXS, Z57.1, N52.35
Drugs: captopril
SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
Reason stopped: 
    due to unmet accrual/randomization goals
  
Eligibility criteria:

        DISEASE CHARACTERISTICS:

          -  One of the following histologically or cytologically confirmed diagnoses:

               -  Stage II-IIIB non-small cell lung cancer (NSCLC)

               -  Stage I central NSCLC

                    -  No peripheral coin lesions

               -  Limited stage small cell lung cancer

                    -  Nonmetastatic disease that is receiving radiotherapy and the target is
                       confined to a single radiotherapy treatment area

          -  Planning to receive radiotherapy

               -  At least 45 Gy to be delivered to the target volume

               -  More than 25% of total lung volume to receive > 20 Gy if receiving radiotherapy
                  alone

        PATIENT CHARACTERISTICS:

        Age

          -  18 and over

        Performance status

          -  Zubrod 0-1

        Hematopoietic

          -  Absolute granulocyte count greater than 1,000/mm^3

          -  Platelet count greater than 75,000/mm^3

          -  Hemoglobin greater than 9.0 g/dL (transfusion allowed)

        Hepatic

          -  Bilirubin less than 1.5 mg/dL

          -  Serum glutamate oxaloacetate transaminase (SGOT) less than 2 times normal

        Renal

          -  Blood urea nitrogen (BUN) less than 25 mg/dL

          -  Creatinine less than 1.6 mg/dL

          -  Urine protein less than 10 mg/dL

          -  Urine glucose negative

        Cardiovascular

          -  Systolic blood pressure greater than 110 mm Hg

          -  Diastolic blood pressure greater than 60 mm Hg

        Other

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective contraception

          -  Sodium normal

          -  Potassium normal

          -  No collagen vascular disease (e.g., lupus or scleroderma)

               -  Rheumatoid arthritis allowed

          -  No known hypersensitivity to ACE inhibitors

        PRIOR CONCURRENT THERAPY:

        Biologic therapy

          -  Not specified

        Chemotherapy

          -  Induction or concurrent chemotherapy allowed either during radiotherapy or during
             therapy with captopril

          -  No concurrent methotrexate

        Endocrine therapy

          -  Not specified

        Radiotherapy

          -  See Disease Characteristics

        Surgery

          -  Prior pulmonary lobectomy or segmentectomy allowed

               -  No prior pneumonectomy

        Other

          -  No concurrent angiotensin-converting enzyme (ACE) inhibitors or angiotensin II
             receptor antagonists for hypertension or congestive heart failure

          -  No concurrent lithium

          -  No concurrent procainamide