Clinical trial NCT00522938 (phase 1/phase 2, status: terminated)
Conditions: carcinoma, non-small-cell lung
ICD codes: D02.20, D02.21, D02.22
Drugs: chr-2797 (tosedostat), erlotinib
SMILES: CC(C)C[C@H]([C@H](O)C(=O)NO)C(=O)N[C@H](C(=O)OC1CCCC1)C1=CC=CC=C1, COCCOC1=CC2=C(C=C1OCCOC)C(NC1=CC(=CC=C1)C#C)=NC=N2
Reason stopped: 
    very poor recruitment of patients to the study
  
Eligibility criteria:

        Inclusion Criteria:

          1. Histologically and/or pathologically confirmed NSCLC (cytologic specimens obtained by
             brushing, washing, or needle aspiration of a defined lesion are acceptable). This
             includes the histologic subtypes of squamous cell, adeno, large cell, anaplastic cell,
             bronchioalveolar carcinoma, and NSCLC not otherwise specified (NOS). Note that tumors
             with the presence of small cell anaplastic elements are not eligible

          2. NSCLC with documentation of Stage IIIB (with pleural effusion), or Stage IV, or
             recurrent metastatic disease based on current TNM classification

          3. Disease progression or relapse following failure of platinum-based chemotherapy

          4. For Study Phase A, patients are not required to have measurable disease (according to
             RECIST criteria) for enrollment. For patients in Study Phase B, patients must have
             measurable disease according to RECIST, defined by at least 1 lesion that can be
             accurately measured. All other lesions (e.g., pleural effusions) including small
             lesions (<1 cm×1 cm by spiral CT scan) are considered non-measurable for the purposes
             of this study. Baseline tumor measurements are to be completed as close as possible
             to, but no longer than 14 days before the start of study treatment

          5. Prior radiation to the measurable site(s) of disease is not allowed, unless disease
             progression has been documented at that site since the radiotherapy. Patients who have
             had extensive radiotherapy are also excluded, because of the associated
             myelosuppressive effect

          6. Prior surgery is allowed, provided it was completed at least 4 weeks prior to
             enrollment and the patient has recovered from surgery.

          7. No known prior primary brain, metastatic brain, or meningeal tumors or clinical signs
             or symptoms of brain metastases

          8. Able to understand and willing to sign an informed consent document

          9. Age ≥18 years

         10. Predicted life expectancy >3 months

         11. Eastern Cooperative Oncology Group (ECOG) performance status score ≤2

         12. Laboratory values within the normal or reasonable ranges and, specifically,adequate
             bone marrow, hepatic, and renal function including the following:

               -  Hemoglobin >10 g/dL, absolute neutrophil count (ANC)>1.5×109/L, platelets
                  ≥100×109/L

               -  Total bilirubin ≤1.5× upper limit normal (ULN)

               -  Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <2.5×ULN or
                  <5×ULN in patients with documented liver metastases

               -  Creatinine ≤1.5×ULN or calculated creatinine clearance ≥60 mL/min

         13. Female patients with reproductive potential must have a negative serum pregnancy test
             within 72 hours prior to start of study medication. All female patients of
             childbearing potential, and all male patients, must agree to use a medically
             acceptable method of contraception or agree to be abstinent throughout the treatment
             period and for 3 months after discontinuation of treatment. (See Section 4.1for more
             information.)

         14. Screening for LVEF >= 55%

        Exclusion Criteria:

          1. Excluded therapies:

               -  Concurrent anti-cancer therapy

               -  Treatment with cytotoxic agents within the last 3 or 4 weeks, depending on the
                  usual frequency of administration of the regimen, or within the last 6 weeks for
                  agents such as mitomycin. Patients must have had resolution of acute
                  treatment-related toxicities to baseline or National Cancer Institute Common
                  Toxicity Criteria (NCI-CTC) Grade <1, with the exception of alopecia

               -  Therapy within the last 28 days or while on study with another investigational
                  drug

               -  Use of biological response modifiers, such as granulocyte-colony stimulating
                  factor (G-CSF) or erythropoietin, within 28 days of enrollment

               -  Prior therapy with an epidermal growth factor receptor (EGFR) inhibitor

               -  Radiation to the site(s) of measurable disease, unless disease progression has
                  been documented at that site since the radiotherapy.

               -  Need for palliative radiotherapy of indicator lesions

               -  Treatment with known strong CYP3A4 inhibitors, for example '- azole antifungals,
                  protease inhibitors, erythromycin, clarithromycin within 2 weeks of enrollment or
                  at any time during the study

               -  Treatment with strong CYP3A4 inducers such as rifampicin, rifabutin or
                  rifapentine within 2 weeks of enrollment or at any time during the study

               -  Warfarin or doses of coumadin (or equivalent) that are higher than 1mg/day

          2. Excluded medical conditions:

               -  Current hematological malignancy

               -  Gastro-intestinal abnormalities including:

                    -  Inability to take oral medication

                    -  Requirement for intravenous (IV) alimentation

                    -  Malabsorption syndrome

                    -  Active peptic ulcer disease

               -  A serious uncontrolled medical disorder or active infection which would impair
                  their ability to receive study treatment

               -  Known primary brain, metastatic brain, or meningeal tumors, or clinical signs or
                  symptoms of brain metastases

               -  Second malignancy (except adequately treated basal cell carcinoma of the skin or
                  in-situ carcinoma of the cervix or breast)

               -  Known history of human immunodeficiency virus (HIV) infection or chronic
                  hepatitis B or C

               -  Uncontrolled hypercalcemia (>NCI-CTC Grade 1)

               -  Significant cardiovascular disease including but not limited to the following:

                    -  History (past or present) of congestive heart failure

                    -  History (past or present) of angina pectoris requiring medication

                    -  History of myocardial infarction with past 12 months

                    -  Presence of clinically significant valvular heart disease

                    -  History (past or present) of arrhythmia requiring treatment

                    -  Presence of conduction defect on Screening ECG

                    -  History (past or present) of uncontrolled hypertension

               -  Patients with interstitial lung disease

          3. Major surgery within 4 weeks prior to enrollment

          4. >20% weight loss in previous 3 months

          5. Pregnant or lactating women

          6. Known rapidly deteriorating liver function tests (2×ULN rise in 1 week)

          7. Dementia or significantly altered mental status that would prohibit the understanding
             or rendering of informed consent and/or compliance with the requirements of the
             protocol

          8. Known or suspected allergy to any study medication used in this study