Clinical trial NCT00646139 (phase 1, status: completed)
Conditions: lymphoma, lymphoproliferative disorder, small intestine cancer, unspecified adult solid tumor, protocol specific
ICD codes: S33.110S, S33.111S, S33.120S, S33.121S, S33.130S, S33.131S, S33.140S, D47.Z1, C17.9, C78.4, D37.2, C17.8, D13.30, D13.39, Z12.13, H01.009, H02.209, H02.009, H02.109, H04.209, H05.409, H10.509
Drugs: src kinase inhibitor kx2-391
SMILES: O=C(CC1=CC=C(C=N1)C1=CC=C(OCCN2CCOCC2)C=C1)NCC1=CC=CC=C1
Eligibility criteria:

        DISEASE CHARACTERISTICS:

          -  Confirmed diagnosis of advanced solid tumor or lymphoma

               -  Metastatic or unresectable disease

               -  Standard curative or palliative measures do not exist or are no longer effective

          -  Patients with treated brain or ocular metastases are eligible

        PATIENT CHARACTERISTICS:

          -  ECOG performance status 0-2

          -  Life expectancy ≥ 14 weeks

          -  ANC ≥ 1,500/mm³

          -  Platelet count ≥ 100,000/mm³

          -  Hemoglobin ≥ 10 g/dL

          -  Serum bilirubin ≤ 2.5 times upper limit of normal (ULN)

          -  ALT and AST ≤ 2.5 times ULN

          -  Alkaline phosphatase ≤ 2.5 times ULN

          -  Serum creatinine ≤ 1.5 times ULN or creatinine clearance > 60 mL/min

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective barrier contraception for 1 month prior to,
             during, and for 6 months after completion of study treatment

          -  No inflammatory bowel disease, malabsorption syndrome, or other medical condition that
             may interfere with oral drug absorption

          -  No signs or symptoms of end organ failure, major chronic illnesses other than cancer,
             or any severe concomitant conditions including, but not limited to, active infections
             that, in the opinion of the investigator, precludes protocol participation or
             compliance

          -  No history of any of the following within the past 6 months:

               -  Angina pectoris

               -  Coronary artery disease

               -  Hypertension

               -  Cerebral vascular accident

               -  Transient ischemic attack uncontrolled by medical therapy

          -  No history of confirmed cardiac conduction abnormalities or arrhythmias

          -  No known history of hepatitis B or C, or HIV infection

          -  No known history of coagulation disorders or hemolytic conditions (e.g., sickle cell
             anemia)

        PRIOR CONCURRENT THERAPY:

          -  Recovered from all prior therapy

          -  No prior major surgery to the upper gastrointestinal tract

          -  More than 2 weeks since prior investigational agents or systemic anticancer agents (28
             days for agents with unknown elimination half-lives or known elimination half-lives >
             50 hours)

          -  More than 4 weeks since prior radiotherapy to the sternum, pelvis, scapulae,
             vertebrae, or skull and recovered

          -  More than 4 weeks since prior major surgery

          -  More than 1 week since prior palliative low-dose radiotherapy to the limbs and
             recovered

          -  More than 2 weeks since prior and no concurrent hormones (e.g., estrogen
             contraceptives, hormone replacement, anti-estrogen, or progesterone) or antiplatelet
             agents

          -  More than 2 weeks since prior and no concurrent anticoagulants (e.g., coumadin) except
             prophylactic doses of anticoagulants for indwelling venous catheters

          -  More than 2 weeks or 5 half-lives since prior and no concurrent cytochrome P450
             modulators (e.g., strong inducers or inhibitors)