Clinical trial NCT00054392 (phase 3, status: withdrawn)
Conditions: lung cancer
ICD codes: C78.00, C78.01, C78.02, D14.30, D14.31, D14.32, C34.2
Drugs: carboplatin, gemcitabine hydrochloride, paclitaxel
SMILES: N[C@@H](CCCNC(N)=N)C(O)=O, NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)C1(F)F, [H][C@@]1(C[C@@H](C)[C@]2([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]3([H])CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](OCCO)[C@@H](C1)OC
Reason stopped: 
    not opened at fox chase cancer center
  
Eligibility criteria:

        DISEASE CHARACTERISTICS:

          -  Histologically confirmed non-small cell lung cancer (NSCLC) of 1 of the following
             types:

               -  Squamous cell

               -  Adenocarcinoma

               -  Large cell anaplastic

               -  Bronchoalveolar

               -  Non-small cell carcinoma not otherwise specified NOTE: Mixed tumors are
                  categorized by the predominant cell type (tumors with small-cell anaplastic
                  elements are ineligible)

          -  Evidence of at least 1 of the following:

               -  Clinically documented recurrent disease after prior radiation or surgery

               -  Stage IV disease (distant metastases)

               -  Stage IIIB disease presenting with 1 of the following:

                    -  Pleural or pericardial effusion by CT scan or chest x-ray

                    -  Pleural implants documented pathologically or seen on CT scan or x-ray

          -  Measurable or evaluable disease

          -  No brain metastases unless clinically stable after surgery and/or radiotherapy

        PATIENT CHARACTERISTICS:

        Age

          -  18 and over

        Performance status

          -  ECOG 0-1

        Life expectancy

          -  Not specified

        Hematopoietic

          -  Absolute neutrophil count at least 1,500/mm^3

          -  Platelet count at least 100,000/mm^3

        Hepatic

          -  Bilirubin no greater than 1.5 mg/dL

          -  AST less than 5 times upper limit of normal

        Renal

          -  Creatinine no greater than 1.5 mg/dL OR

          -  Creatinine clearance at least 40 mL/min

        Other

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective contraception

          -  No hypersensitivity to agents that contain Cremophor EL (polyoxyethylated castor oil)

        PRIOR CONCURRENT THERAPY:

        Biologic therapy

          -  Not specified

        Chemotherapy

          -  No prior chemotherapy for advanced NSCLC

        Endocrine therapy

          -  Not specified

        Radiotherapy

          -  See Disease Characteristics

          -  Recovered from prior radiotherapy

          -  No prior radiotherapy to the only site of measurable disease, unless the site had
             subsequent progression of disease documented by physical exam, radiography, or
             pathology

          -  No concurrent radiotherapy (except for brain metastases)

        Surgery

          -  See Disease Characteristics

        Other

          -  No concurrent aminoglycoside antibiotics