Clinical trial NCT00368030 (phase 3, status: completed)
Conditions: insomnia, depressive disorder, major
ICD codes: F51.01, F51.02, F51.03, F51.04, G47.00, G47.09, A81.83, F33.0, F33.1, F33.9, F32.0, F32.1, F32.9, F33.40
Drugs: eszopiclone
SMILES: CN1CCN(CC1)C(=O)O[C@@H]1N(C(=O)C2=NC=CN=C12)C1=NC=C(Cl)C=C1
Eligibility criteria:

        Inclusion Criteria:

          -  Subject must understand the purpose of the study and be willing to adhere to the study
             schedule and procedures described in this protocol.

          -  Subject must be 21 to 64 years of age (inclusive) on the day of signing consent.

          -  Subject must meet criteria for a primary and principal diagnosis of Major Depressive
             Disorder.

          -  Subject's current depressive episode is at least 2 weeks but not longer than 6 months
             in duration.

          -  Subject must meet criteria for insomnia related to MDD and the symptoms of insomnia
             must not pre-date the symptoms of MDD by more than 10 weeks.

          -  Subject must report a sleep onset time of > 30 minutes, and wake time after sleep
             onset of > 45 minutes, and < 6.5 hours of total sleep time at least three times a week
             over the previous month.

          -  Subject must take the Hamilton-D-17 scale and have a protocol pre-specified minimum
             score.

          -  Subject must have no known clinically significant abnormal laboratory, ECG, or
             physical examination findings at screening.

          -  Subject must meet one of the following conditions:

          -  Subject is not taking antidepressant medications at the time of study start.

          -  Subject is taking a sub-therapeutic dose of antidepressant or other disallowed
             psychotropic medication and with the approval of the investigator agrees to taper off
             of this medication, prior to completion of screening assessments at study start.

        Exclusion Criteria:

          -  Female subject is pregnant, lactating or within 6 months post partum.

          -  Subject has known sensitivity to any selective SSRI, zopiclone, or eszopiclone.

          -  Subject has history of major depressive disorder that was refractory to treatment with
             SSRIs.

          -  Subject has a current primary psychiatric diagnosis of any of the following disorders:
             dementia, delirium, schizophrenia, psychosis, other psychotic disorders, dysthymic
             disorder; bipolar disorders; cyclothymic disorder, other mood disorders, nocturnal
             panic disorder, primary anxiety disorders, primary panic disorders or any other
             psychiatric disorder that would compromise the investigator's ability to evaluate the
             safety and efficacy of the study medication.

          -  Note: Subjects with Sexual and Gender Identity Disorders or other non-psychotic
             disorders will be considered on a case-by-case basis. Subjects with MDD and a
             secondary diagnosis of generalized anxiety disorder, panic disorders other than
             nocturnal panic disorder or seasonal affective disorder will be allowed.

          -  Subject has any of the following Personality Disorders diagnoses: schizotypal,
             schizoid, borderline personality disorder; mental retardation or any other personality
             disorder that would compromise the investigator's ability to evaluate the safety and
             efficacy of the study medication.

          -  Subject has difficulties in sleep initiation or maintenance associated with known
             medical diagnosis [e.g. sleep apnea, restless leg syndrome (RLS), or periodic leg
             movement syndrome (PLMS)], or has any condition that has or may affect sleep [(e.g.,
             chronic pain, benign prostatic hypertrophy (BPH)].

          -  Subject has any clinically significant unstable medical or neurologic abnormality,
             unstable chronic disease, or a history of a clinically significant abnormality of the
             cardiovascular, respiratory, hepatic, or renal systems.

          -  Subject has a disorder or history of a condition (e.g., malabsorption,
             gastrointestinal surgery) that may interfere with drug absorption, distribution,
             metabolism, or excretion.

          -  Subject has a history of malignancy within 5 years, or current malignancy, except for
             non-melanoma skin cancer.

          -  Subject has a history of drug or alcohol abuse or dependence in the past 6 months or
             positive urine drug and alcohol test at screening.

          -  Subject is participating in, has participated in, or plans to participate in any
             investigational drug study within 30 days prior to screening until the end of this
             study.

          -  Subject has history of circadian rhythm disorder, or travels across >3 time zones on a
             regular basis.

          -  Subject is known to be seropositive for Human Immunodeficiency Virus (HIV).

          -  Subject has used any drugs known or suspected to affect hepatic or renal clearance
             capacity within a period of 30 days prior to screening.

          -  Subject is unwilling to refrain from drinking alcoholic beverages during study
             participation.

          -  Subject is a rotating or third/night shift worker.

          -  Subject is a staff member or relative of a staff member.