Clinical trial NCT00147264 (phase 3, status: completed)
Conditions: metabolic syndrome x
ICD codes: E88.81, G93.41, E88.9, P19.9, E88.89, O21.1, P19.2
Drugs: telmisartan (micardis®) vs. placebo
SMILES: CCCC1=NC2=C(C=C(C=C2C)C2=NC3=CC=CC=C3N2C)N1CC1=CC=C(C=C1)C1=CC=CC=C1C(O)=O
Eligibility criteria:

        Inclusion Criteria:

          -  Written informed consent

          -  Between 30 and 70 years of age

          -  Abdominal obesity defined as increased waist circumference (Men >102cm (>40in), Women
             >88cm (>35in)), with or without any of the following additional criteria of the
             metabolic syndrome:

          -  Triglycerides >=1.7mmol/L (>=150 mg/dL and/or on prescribed lipid lowering medication
             for > 3 months)

          -  HDL cholesterol

          -  Men <1.0 mmol/L (<40 mg/dL)

          -  Women <1.3 mmol/L (<50 mg/dL)

          -  Blood pressure >=130 and/or >=85 mmHg and/or on anti-hypertensive therapy (except
             ACE-I or ARB)

          -  Fasting glucose >=6.1 mmol/L (>=110 mg/dL)

          -  Ability and willingness to complete dietary and activity diaries and questionnaires.

        Exclusion Criteria:

          -  Participant has taken ACE inhibitor or ARB in the last 3 months, or in the opinion of
             the study physician currently has indication for either of these medications

          -  Concurrent antidiabetic medication

          -  Use of systemic glucocorticosteroids (topical and inhaled are acceptable)

          -  On lipid-lowering medication and NOT on stable dose for the last three months

          -  If the participant has any one or more of the following medical disorders:

               1. diabetes mellitus and/or FBG >=7.0 mmol/L on two separate occasions within the
                  screening period

               2. uncontrolled hypertension (SBP >=160 mmHg and/or DBP >=100 mmHg) or known
                  participants with secondary causes of hypertension

               3. biliary obstruction

               4. hepatic dysfunction as defined by SGPT (ALT) > 3 times the upper limit of normal
                  range

               5. renal dysfunction as defined by serum creatinine > 130umol/L AND/OR proteinuria
                  1+ or greater (dipstick)

               6. serum triglycerides >10 mmol/L

               7. history of hypertrophic obstructive cardiomyopathy, hemodynamically relevant
                  stenosis of the aortic or mitral valve

               8. sodium depletion or hyperkalemia.

               9. uncorrected volume depletion

              10. endocrine disorder (e.g. hyperthyroidism, Cushing's syndrome, acromegaly, etc.)
                  Participants on thyroid-replacement therapy and TSH < 5.0 mU/L may be enrolled in
                  the study.

              11. contraindications to study diet

              12. any major surgery that is, at the time of screening, planned to take place during
                  the study period.

              13. previously angioedema with ACE Inhibitor or ARB or known hypersensitivity to any
                  component of the study drug formulations (e.g. hereditary fructose intolerance)

              14. history of drug or alcohol dependency within six months prior to signing the
                  informed consent form.

              15. history of active malignancy, chronic inflammatory disorder, or chronic
                  infections which would interfere with protocol completion.

              16. any other medical, social or geographic condition, which, in the opinion of the
                  investigator would not allow safe completion of the protocol and/or safe
                  administration of trial medication

          -  If the participant has any contraindications to MRI

          -  Pre-menopausal women (last menstruation >=1 year prior to consent) who:

               1. are not surgically sterile or

               2. are nursing, or pregnant, or

               3. are of child-bearing potential and are NOT practicing acceptable methods of birth
                  control, or do NOT plan to continue practicing an acceptable method throughout
                  the study, AND do not agree to periodic pregnancy testing during participation in
                  the study.

          -  Intention to go on weight - reducing medications or weight-loss diets during the study
             period

          -  Significant fluctuations in weight over past 3 months(e.g. >10%)

          -  Household member currently in study

          -  Any investigational drug therapy within one month of signing the informed consent
             form.

          -  Participant has knowledge that he/she will be unable to consume study foods for >2
             weeks during treatment phase of study

          -  <70% compliant during run-in

          -  Unable to reduce total fat consumption to <40% and/or reduce saturated fat consumption
             to <15% during run-in