Clinical trial NCT00203372 (phase 2, status: completed)
Conditions: breast cancer
ICD codes: C79.81, D24.1, D24.2, D24.9, D49.3, C44.501, D48.60
Drugs: bevacizumab 7.5 and tac, placebo 7.5 and docetaxel, doxorubicin, and cyclophosphamide (tac), bevacizumab 15 and tac, placebo 15 and tac
SMILES: [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1, ClCCN(CCCl)P1(=O)NCCCO1, [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Histologically or cytologically proven adenocarcinoma of the breast

          -  Stage II (T > 3 cm) or Stage III disease (except inflammatory breast cancer),
             according to the AJCC Staging Manual, 6th Edition, 2002

          -  HER2-negative disease (as defined by fluorescence in situ hybridization [FISH])

          -  ECOG performance status 0-1

          -  No prior chemotherapy, radiotherapy, or endocrine therapy for invasive or noninvasive
             breast cancer

          -  Normal cardiac function (ejection fraction > lower limit of normal) as determined by
             MUGA or echocardiogram

          -  Adequate organ function

        Exclusion Criteria:

          -  Prior chemotherapy or radiotherapy for Stage II or Stage III breast cancer

          -  Inflammatory Breast Cancer, clinically defined as the presence of erythema or
             induration involving one-third or more of the breast

          -  Prior treatment with an anti-angiogenic agent

          -  Prior ipsilateral radiation therapy for invasive or non-invasive breast cancer

          -  Bilateral invasive breast cancer

          -  Concurrent therapy with any other non-protocol anti-cancer therapy

          -  Current therapy with hormone replacement therapy, or any hormonal agent such as
             raloxifene, tamoxifen, or other selective estrogen receptor modulators (agents must be
             stopped prior to randomization)

          -  Presence of neuropathy > grade 2 (NCI-CTC version 3.0) at baseline

          -  Presence of any non-healing wound, bone fracture, or ulcer, or the presence of
             clinically significant (> grade 2) peripheral vascular disease

          -  History of any other malignancy within the past 5 years, with the exception of
             non-melanoma skin cancer or carcinoma-in-situ of the cervix

          -  Clinically significant cardiovascular disease (e.g., hypertension [BP > 150/100],
             myocardial infarction or stroke within 6 months, unstable angina), New York Heart
             Association (NYHA) Grade II or greater congestive heart failure, or serious cardiac
             arrhythmia requiring medication

          -  Active peptic ulcer disease, inflammatory bowel disease, or other gastrointestinal
             condition increasing the risk of perforation; history of abdominal fistula,
             gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to
             beginning therapy

          -  Active, uncontrolled infection requiring parenteral antimicrobials

          -  The presence of any other medical or psychiatric disorder that, in the opinion of the
             treating physician, would contraindicate the use of the drugs in this protocol or
             place the subject at undue risk for treatment complications

          -  Pregnancy or lactation

          -  A history of a severe hypersensitivity reaction to bevacizumab, or docetaxel or other
             drugs formulated with polysorbate 80

          -  Evidence of bleeding diathesis or coagulopathy

          -  Major surgical procedure, open biopsy, or significant traumatic injury within 28 days
             prior to beginning therapy, or anticipation of the need for a major surgical procedure
             during the course of the study; minor surgical procedure, fine needle aspiration, or
             core biopsy within 7 days prior to beginning therapy

          -  Urine protein:creatinine ratio of > 1.0 at screening