Clinical trial NCT00733889 (phase 2, status: completed)
Conditions: esophageal carcinoma
ICD codes: C22.0, C22.1, C4A.9, C7B.1, D09.9, C4A.0, C4A.31
Drugs: cetuximab and chemotherapy (docetaxel, cisplatin, 5-fluorouracil)
SMILES: [H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H]
Eligibility criteria:

        Inclusion Criteria:

          -  Informed consent form signed before performing any of the study's specific procedures.

          -  Age > 18 and < 70.

          -  Karnofsky performance status > 70% upon inclusion in the study.

          -  Life expectancy of more than 3 months.

          -  Histologically confirmed diagnosis of squamous cell carcinoma or adenocarcinoma of the
             oesophagus or the gastroesophageal junction. The disease must be confined to the
             oesophagus or gastroesophageal junction and the perioesophageal region. There must be
             no tumor extension beyond 2 cm into the stomach.

          -  Stages II or III. The patients must have a T1N1M0 or T2-4; any N; M0. The only
             exception would be patients with stage IVA: an oesophageal carcinoma of the upper
             thoracic region with metastasis in cervical lymph nodes (M1a) and an oesophageal
             carcinoma of the lower thoracic region with metastasis in the celiac lymph nodes
             (M1a), providing the disease remains within the radiotherapy fields.

          -  Presence of a unidimensionally measurable and/or assessable lesion

          -  Neutrophils >1500/mm3, platelet count >150,000/mm3 and haemoglobin >10 g/dl.

          -  Adequate renal function: serum creatinine < 120 micromol/l (1.4 mg/dl); if the values
             are >120 micromol/l (1.4 mg/dl) creatinine clearance must be > 65 ml/min.

          -  Adequate liver function: total bilirubin <1 x NUL; aspartate aminotransferase (AST)
             and alanine aminotransferase (ALT) <2.5 x NUL; alkaline phosphatase (AP) < 5 x NUL.
             Patients with AST and/or ALT > 1.5 < 2.5 x NUL and AP > 1.5 x NUL < 5 x NUL are not
             eligible.

          -  Serum calcium <1.25 x normal upper limit (NUL).

          -  Adequate nutritional status: weight loss < 20% of regular weight and albumin > 35 g/l.

          -  Total oral and/or enteral intake should be at least 1700 calories/day.

          -  Use of an effective contraceptive method for patients of both sexes when there is a
             risk of conception and/or pregnancy.

          -  Availability of tumour tissue for immunohistochemical analysis of EGFR expression and
             other biological markers.

        Exclusion Criteria:

          -  Patients with a tracheo-oesophageal fistula or direct invasion of the tracheal mucosa
             or a major bronchi are not eligible. Bronchoscopy (with biopsy and cytology if lesion
             is seen) is required in order to rule out a fistula and/or direct invasion if the
             primary tumour is < than 30 cm from the incisors. Bronchoscopy is also required when
             the primary tumour is shown to be at or above the carina by an imaging study.

          -  Prior thoracic radiotherapy and/or systemic chemotherapy and/or oesophageal surgery.

          -  Patients with multiple carcinoma of the oesophagus.

          -  Diagnosis of any other cancer in the previous 5 years with the exception of
             appropriately treated carcinoma in situ of the uterine cervix and/or basal cell
             carcinoma of the skin.

          -  Systemic, chronic and concomitant immune treatment, or anti-cancer hormone therapy.

          -  Other concomitant cancer treatments.

          -  Active infection (infection requiring intravenous antibiotics), including active
             tuberculosis and diagnosed HIV.

          -  Uncontrolled hypertension defined as systolic blood pressure > 180 mmHg and/or
             diastolic blood pressure > 130 mmHg at rest.

          -  Active, uncontrolled, gastric or duodenal peptic ulcer.

          -  Chronic obstructive pulmonary disease requiring hospitalisation in the 6 months prior
             to inclusion in the study.

          -  History of atrioventricular arrhythmia and/or cardiac failure and/or second or third
             degree heart block.

          -  Clinically significant coronary artery disease or history of myocardial infarction in
             the last 12 months .

          -  Peripheral neuropathy grade > 2 NCIC-CTG of any aetiology.

          -  Hearing disorder grade > 2 NCIC-CTG of any aetiology.

          -  Any other disease or medical disorder suggesting that the patient will not be able to
             complete the study.

          -  Any psychological disorder suggesting that the complete treatment will not be
             possible.

          -  Pregnancy (its absence must be confirmed by the serum HCG-betatest) or lactation.

          -  Known drug abuse (with the exception of the mild or moderate consumption of alcohol
             upon inclusion in the study).

          -  Known allergic reaction to any of the components in the study treatment.

          -  Prior treatment with monoclonal antibodies or other signal transduction inhibitors or
             EGFR-targeted treatment.

          -  Evidence of another cancer, with the exception of a carcinoma in situ of the uterine
             cervix and/or a basal cell carcinoma of the skin.

          -  Any experimental treatment in the 30 days prior to inclusion in the study.