Clinical trial NCT01039805 (phase 2, status: completed)
Conditions: gastroparesis
ICD codes: K31.84
Drugs: gsk962040 (50 mg), placebo, gsk962040 (75 mg)
SMILES: C[C@H]1CN(CC2=CC=C(CC(=O)N3CCC(CC3)NC3=CC=CC(F)=C3)C=C2)CCN1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, C[C@H]1CN(CC2=CC=C(CC(=O)N3CCC(CC3)NC3=CC=CC(F)=C3)C=C2)CCN1
Eligibility criteria:

        Inclusion Criteria:

          -  Male or female between 18-85 years of age, at the time consent is obtained.

          -  Mechanically ventilated on the Intensive Care Unit who has become intolerant of
             nasogastric enteral feeding.

          -  intolerance of nasogastric tube feeding is defined as a gastric aspirate volume (GRV)
             >250 mL at least 6 hours after commencing feeding at >40 mL/hr.

          -  Expected to remain mechanically ventilated for at least 48 hours after enrollment and
             expected to survive for at least 24 hours post dose of study medication.

          -  Subject has a nasogastric tube for enteral feeding.

          -  Body weight > or = 50 kg

          -  Written informed consent may be obtained from a legally acceptable representative,
             which includes compliance with the requirements and restrictions listed in the consent
             form. In most cases, consent will be sought from next of kin as the subject will not
             be competent to give their own consent.

          -  Average QTcB or QTcF < 450 msec; or QTc < 480 msec in subjects with Bundle Branch
             Block.

          -  AST and ALT < 3xULN; alkaline phosphatase and bilirubin < or = 2xULN.

          -  Subjects who have rapidly rising aminotransferases or for whem there is not a
             plausible explanation for the observed elevation will not be enrolled

          -  LFTs will be checked for eligibility on screening and again prior to dosing with
             GSK962040.

        Exclusion Criteria:

          -  Subjects that have received a gastric prokinetic agent in the previous 24 h (e.g.,
             erythromycin, azithromycin, metoclopramide). These agents are prohibited for the
             duration of the study.

          -  Subjects whose clinical condition is deteriorating rapidly or any subject for whom the
             investigator does not consider there is a reasonable expectation that they will be
             able to complete the study.

          -  Subjects who are known to be infected with Hepatitis B, Hepatitis C, or HIV viruses.

          -  Current or chronic history of liver disease, or known hepatic or biliary abnormalities
             (with the exception of Gilbert's syndrome or asymptomatic gallstones).

          -  The subject has participated in a clinical trial and has received an investigational
             product within the following time period prior to the first dosing day in the current
             study: 30 days, 5 half-lives or twice the duration of the biological effect of the
             investigational product (whichever is longer).

          -  Exposure to more than four new chemical entities within 12 months prior to the first
             dosing day.

          -  Use of prohibited medications listed in Section 9.2 within the restricted timeframe
             relative to dosing of study medication.

          -  Subjects with renal failure requiring replacement therapy (dialysis or filtration).

          -  Subjects for whom the reason for admission to ICU was an overdose (deliberate or
             accidental; medicinal product or not).

          -  Subjects with altered upper gastrointestinal tract anatomy and subjects who have
             undergone upper gastrointestinal tract surgery on this admission to ICU.

          -  Subjects with bowel obstruction or perforation.

          -  Subject has a gastric pacemaker

          -  Subject is receiving parenteral feeding

          -  History of sensitivity to any of the study medications, or components thereof or a
             history of drug or other allergy that, in the opinion of the investigator or GSK
             Medical Monitor, contraindicates their participation.

          -  Pregnant females as determined by positive serum or urine hCG test at screening or
             prior to dosing.

          -  Lactating females.