Clinical trial NCT01387204 (phase 1, status: completed)
Conditions: cancer
ICD codes: C05.2, C10.0, C16.0, C16.4, C17.0, C17.1, C17.2
Drugs: gsk1120212
SMILES: CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=CC=C(I)C=C1F)C1=CC(NC(C)=O)=CC=C1
Eligibility criteria:

        Inclusion Criteria:

          1. Male 18 years old or older.

          2. Written informed consent provided

          3. Body weight greater than or equal to 45 kg and a BMI greater than or equal to 19 kg/m2
             and less than or equal to 35 kg/m2 (inclusive).

          4. Able to swallow and retain oral medication.

          5. Histologically or cytologically confirmed diagnosis of a solid tumor.

          6. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1.

          7. Agree to use one of the contraception methods listed in the protocol from the time of
             the first dose of study medication until sixteen weeks after the last dose of study
             medication.

          8. A history of regular bowel movements (approximately once per day).

          9. Adequate baseline organ function as listed in the protocol.

        Exclusion Criteria:

          1. Currently receiving cancer therapy as specified in the protocol.

          2. Serious and/or unstable pre-existing medical psychiatric disorder, or other
             conditions.

          3. Any major surgery within the last four weeks.

          4. Unresolved toxicity equal to or greater than Grade 2 from previous anti-cancer therapy
             except alopecia.

          5. An occupation within the past 12 months which requires monitoring for radiation
             exposure, nuclear medicine procedures or excessive x-rays.

          6. Radiation exposure from the previous three year period over 10 mSv if exposed to
             ionizing radiation above background as a result of work with radiation as category A
             (classified) workers or as a result of research studies.

          7. History of interstitial lung disease or pneumonitis.

          8. Known immediate or delayed hypersensitivity reaction or idiosyncrasy to dimethyl
             sulfoxide (DMSO).

          9. Current use of a prohibited medications described in the protocol.

             • Use of anticoagulants such as warfarin is permitted.

         10. History RVO or CSR.

               -  Predisposing factors to RVO or CSR.

               -  Visible retinal pathology that is considered a risk factor for RVO or CSR such
                  as:

                  - Evidence of new optic disc cupping

                  - Intraocular pressure greater than 21 mm Hg as measured by tonography. 11.1.
                  Symptomatic or untreated leptomeningeal or brain metastases or spinal cord
                  compression. (Previously treated and have had stable CNS disease for greater than
                  3 months, asymptomatic and off corticosteroids, or on stable dose of
                  corticosteroids for at least 1 month prior to study Day 1 are permitted).

        11.2. Receiving enzyme inducing anti-epileptic drugs (EIAEDs). 12. History of acute
        coronary syndromes (including myocardial infarction and unstable angina), coronary
        angioplasty, or stenting within the past 6 months. 13. QTcB greater than or equal to 480
        msec. 14. History or evidence of current clinically significant uncontrolled arrhythmias.

        15. History or evidence of current greater than or equal to Class II congestive heart
        failure.

        16. Active gastrointestinal disease or other condition (e.g., gastrectomy, bariatric
        surgery, small bowel or large bowel resection, or cholecystectomy).

        17. A history of known Human Immunodeficiency Virus (HIV), Hepatitis B Virus, or Hepatitis
        C Virus.

        18. Alcohol or drug abuse within six months prior to screening. 19. Known immediate or
        delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to the study
        drugs or excipients.

        20. Participated in a clinical trial and has received an investigational product within 30
        days or five half-lives or twice the duration of the biological effect of the
        investigational product (whichever is longer) before the 1st dose.

        21. Where participation in the study would result in donation of blood or blood products in
        excess of 500 mL within a 56 day period.

        22. Mentally or legally incapacitated.