Clinical trial NCT00640484 (phase 2, status: completed)
Conditions: chronic obstructive pulmonary disease
ICD codes: J44.9, J44.1, J44.0
Drugs: carmoterol (chf 4226), carmoterol (chf 4226), placebo, salmeterol
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, OCC1=C(O)C=CC(=C1)C(O)CNCCCCCCOCCCCC1=CC=CC=C1
Eligibility criteria:

        Inclusion Criteria:

          -  Signed IRB approved Informed Consent form

          -  Male or non-pregnant female, 40 -75 years old, inclusive

          -  Current or past cigarette smoking history of at least 15 pack-years

          -  Clinical diagnosis of COPD in accordance with recommendations of the National Heart
             Lung and Blood Institute/World Health Organization (NHLBI/WHO) Global Initiative for
             Chronic Obstructive Lung Disease (GOLD)

          -  Patient meets following requirements after FEV1 albuterol reversibility test (i.e., 30
             minutes after 200μg (metered dose) albuterol MDI):

               -  FEV1/FVC < 70%

               -  FEV1 is at least 0.9L

               -  FEV1 30% - 80%, inclusive, of patient's predicted normal value; ∆FEV1 > 5% of
                  pre-albuterol value

               -  If ∆FEV1 < 5% of pre-albuterol value, requirement must be met after retesting
                  during run-in period, at least 24 hours prior to Period 1/Visit 1.

        Exclusion Criteria:

          -  History of asthma

          -  Blood eosinophil count > 500/microliters

          -  History of allergic rhinitis or atopy

          -  COPD exacerbation or lower respiratory tract infection within 8 weeks prior to
             screening, or during run-in period, that resulted in use of an antibiotic, or oral or
             parenteral corticosteroids

          -  Inhaled corticosteroid that has been initiated, or effective dose has been changed,
             within 4 weeks prior to screening or during run-in period

          -  Uncontrolled cardiovascular (e.g., uncontrolled hypertension), respiratory,
             hematologic, immunologic, renal, neurologic, hepatic, endocrine (e.g., uncontrolled
             diabetes mellitus) or other disease, or any condition that might, in Investigator's
             judgment, place patient at undue risk or potentially compromise study results or
             interpretation

          -  History of coronary artery disease, cerebrovascular disease, cardiac arrhythmias

          -  Lung cancer or history of lung cancer

          -  Active cancer or history of cancer with < 5 years disease free survival time (with or
             without evidence of local recurrence or metastases). Localized basal cell carcinoma
             (without metastases) of skin is acceptable.

          -  Serum potassium value ≤ 3.5 mEq/L or > 5.5mEq/L and/or fasting serum glucose value ≥
             140 mg/dL

          -  Abnormal QTcF interval value in Screening visit ECG test (i.e., > 450 msec in males or
             > 470 msec in females)

          -  Cor Pulmonale

          -  Long term oxygen therapy, i.e., > 16 hours/24-hour period, every day, unless patient
             resides at elevation > 4000ft

          -  Use of any of the following medications prior to Screening, without meeting specified
             minimum washout period:

               -  Long acting anti-cholinergic agent (i.e., tiotropium): 7 days

               -  Short acting anti-cholinergics: 8 hours

               -  Fixed combinations of β2-agonists and inhaled corticosteroids: 48 hours

               -  Fixed combinations of an anti-cholinergic and short acting β2-agonist: 8 hours

          -  Long-acting β2-agonists: 48 hours

          -  Short acting β2-agonists (other than those prescribed in the study): 6 hours

          -  Theophylline and other xanthines: 1 week

          -  Parenteral or oral corticosteroids: 1 month

          -  Patient has taken any non-permitted medication

          -  Patient has received live-attenuated virus vaccination within two weeks prior to
             screening or during run-in (inactivated Influenza vaccination is acceptable if given >
             48 hours prior to Screening)

          -  Known intolerance/hypersensitivity to β2-adrenergic agonists, propellant
             gases/excipients

          -  Patient is pregnant or lactating female, or female at risk of pregnancy (i.e., not
             using adequate contraceptive method: surgical sterilization [e.g., bilateral tubal
             ligation], hormonal contraception [implantable, patch, oral], IUD, and double-barrier
             methods [any double combination of: male or female condom with spermicidal gel,
             diaphragm, sponge, cervical cap]).

          -  Patient is mentally or legally incapacitated

          -  Patient has participated in another investigational study within 30 days prior to
             screening

          -  Abuse of alcohol or other substances

          -  Patient does not maintain regular day/night, waking/sleeping cycles (e.g., night shift
             worker)

          -  Patient is potentially non-compliant or unable to perform required protocol outcome
             measurements