Clinical trial NCT00003041 (phase 2, status: completed)
Conditions: breast cancer
ICD codes: C79.81, D24.1, D24.2, D24.9, D49.3, C44.501, D48.60
Drugs: pyrazoloacridine
SMILES: NC(=O)C1=NC=CN=C1
Eligibility criteria:

        DISEASE CHARACTERISTICS: Histologically confirmed metastatic breast cancer Bidimensionally
        measurable disease of any of the following types required: Bidimensionally measurable lung
        lesions on chest X-ray, CT scan, or MRI Palpable and quantifiable lymph nodes at least 2 x
        2 cm Abdominal mass at least 2 x 2 cm quantifiable by CT scan Bidimensionally measurable
        liver metastases at least 2 x 2 cm Palpable hepatomegaly if liver edge is clearly defined
        and extends at least 5 cm below the costal margin of the xiphoid process Unacceptable as
        measurable disease: Diffuse lung infiltration or unidimensionally measurable hilar lesions
        Pelvic mass of indefinite dimension Bone metastases Pleural effusion or ascites No brain
        metastases Must have failed or progressed on prior therapy or relapsed less than 12 months
        after therapy discontinuation Hormone receptor status: Not specified

        PATIENT CHARACTERISTICS: Age: 16 and over Sex: Female Menopausal status: Not specified
        Performance status: SWOG 0-2 Life expectancy: At least 6 months Hematopoietic: Granulocyte
        count at least 1,500/mm3 Platelet count at least 100,000/mm3 Hepatic: SGOT no greater than
        2.5 times upper limit of normal Bilirubin no greater than 1.5 mg/dL Renal: Creatinine no
        greater than 1.5 mg/dL OR Creatinine clearance at least 60 mL/min Cardiovascular: No
        history of congestive heart failure, myocardial infarction within past 6 months,
        ventricular arrhythmia, or ischemic heart disease requiring medication If necessary,
        ejection fraction at least 50% by MUGA Other: Not pregnant or nursing Negative pregnancy
        test Fertile patients must use effective contraception No other prior malignancies in past
        5 years other than basal cell or squamous cell carcinoma of the skin or carcinoma in situ
        of the cervix No other serious illnesses or active infections No seizure disorder requiring
        anticonvulsant therapy

        PRIOR CONCURRENT THERAPY: Biologic therapy: No concurrent biologic therapy Chemotherapy:
        See Disease Characteristics No more than 2 prior chemotherapy regimens for metastatic
        disease One prior adjuvant chemotherapy regimen for metastatic disease allowed At least 4
        weeks since prior chemotherapy No other concurrent chemotherapy Endocrine therapy: One
        prior regimen of hormonal therapy for metastatic disease allowed At least 3 weeks since
        prior hormonal therapy and recovered No concurrent hormonal or corticosteroid therapy
        Radiotherapy: At least 4 weeks since prior radiotherapy to less than 25% bone marrow No
        concurrent radiotherapy Surgery: At least 4 weeks since prior surgery and recovered No
        concurrent surgery Other: At least 4 weeks since any prior treatment directed at the tumor
        and recovered No other concurrent anticancer or investigational therapy No concurrent
        participation on another therapeutic clinical trial