Clinical trial NCT00421642 (phase 1, status: completed)
Conditions: ulcerative colitis
ICD codes: K51.80, K51.813, K51.814, K51.90, K51.913, K51.914, K51.811
Drugs: adalimumab
SMILES: O
Eligibility criteria:

        Inclusion Criteria

          1. Males and females 18 years of age and older

          2. Female subjects must utilize a highly effective method of birth control throughout the
             study and for 70 days after study completion, or female subjects must not be of
             childbearing potential, defined as postmenopausal at least two years, or surgically
             sterile (bilateral tubal ligation, bilateral oophorectomy, or hysterectomy).

          3. A diagnosis of UC for greater than 3 months.

          4. UC diagnosis confirmed by endoscopy with exclusion of infectious cause.

          5. Active ulcerative colitis with a Mayo Clinic Score (see Appendix C) of 6 to 12 points
             with moderately-to-severely active disease on sigmoidoscopy (endoscopic subscore of at
             least 2) despite concurrent treatment with corticosteroids, and/or azathioprine or 6
             mercaptopurine and/or 5-aminosalicylate-containing medications. Patients who
             previously have not responded to or could not tolerate corticosteroids (within the
             past 18 months), or azathioprine or 6 mercaptopurine (both within the past 5 years),
             or 5 aminosalicylate-containing medications (within the past 18 months) will not
             required to be taking concurrent therapy at enrollment.

          6. Either anti-TNF agent naïve or those with previous clinical response to infliximab
             therapy for UC with subsequent loss of response AND/OR are unable to tolerate further
             infliximab therapy for UC due to acute or delayed reactions, as defined by the
             investigator.

          7. Subjects must be able and willing to give written informed consent and to comply with
             the requirements of this study protocol.

          8. Adequate cardiac, renal and hepatic function as determined by principal investigator
             and demonstrated by screening laboratory evaluations, questionnaires, and physical
             examination results that are within normal limits.

        Exclusion Criteria

          1. History of cancer or lymphoproliferative disease other than a successfully and
             completely treated squamous cell or basal cell carcinoma of the skin.

          2. Subjects with a history of Listeria, Hepatitis B infection, central nervous system
             (CNS) demyelinating disease, or human immunodeficiency virus (HIV) or a history of
             previously untreated TB. See Appendix B.

          3. Subjects with Crohn?s Disease

          4. Subjects with symptomatic obstructive strictures

          5. Subjects who have had subtotal colectomy with ileorectostomy or colectomy with
             ileoanal pouch, Kock pouch, or ileostomy for ulcerative colitis or are planning
             subtotal colectomy or colectomy within 8 weeks of starting the study medication.

          6. Subjects who are currently receiving total parenteral nutrition (TPN).

          7. Any investigational chemical agent in the past 30 days or 5 half-lives prior to
             screening (whichever is longer). Patients who have previously been treated with
             infliximab and responded, and then become intolerant to infliximab or lost response,
             can be treated >/= 4 weeks from their last infliximab dose.

          8. Antibiotic treatment for any systemic infection within 3 weeks prior to screening.

          9. Female subjects who are pregnant or breast-feeding.

         10. History of clinically significant drug or alcohol abuse in the prior year.

         11. Poorly controlled medical condition, including but not limited to diabetes with
             documented history of recurrent infections or cerebrovascular accidents (within 3
             months).

         12. Subjects who have been on cyclosporine or tacrolimus within 4 weeks of screening.

         13. Subjects who have been on methotrexate within 4 weeks of screening.