Clinical trial NCT00280150 (phase 1/phase 2, status: completed)
Conditions: lung cancer
ICD codes: C78.00, C78.01, C78.02, D14.30, D14.31, D14.32, C34.2
Drugs: carboplatin, erlotinib hydrochloride, paclitaxel
SMILES: N[C@@H](CCCNC(N)=N)C(O)=O, COCCOC1=CC2=C(C=C1OCCOC)C(NC1=CC(=CC=C1)C#C)=NC=N2, [H][C@@]1(C[C@@H](C)[C@]2([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]3([H])CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](OCCO)[C@@H](C1)OC
Eligibility criteria:

        DISEASE CHARACTERISTICS:

          -  Diagnosis of non-small cell lung cancer

               -  Stage IIIA or IIIB disease

               -  No malignant pleural or pericardial effusions

               -  No palpable supraclavicular adenopathy

          -  Squamous cell histology allowed provided there is no hemoptysis and no central
             invasive lesions that abut or invade major blood vessels in the chest (with or without
             cavitation)

          -  Considered suitable and appropriate for combined modality therapy and thoracic
             conformal radiotherapy, as determined by the treating medical and radiation oncologist

        PATIENT CHARACTERISTICS:

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0-1

          -  Hemoglobin ≥ 9.0 mg/dL

          -  Platelet count ≥ 100,000/mm³

          -  Absolute neutrophil count (ANC) ≥ 1,500/mm³

          -  Forced expiratory volume 1 (FEV_1) ≥ 1 L

          -  Creatinine ≤ 1.5 times upper limit of normal (ULN)

          -  Aspartate Aminotransferase (AST) or Alanine Aminotransferase (ALT) ≤ 2.5 times ULN

          -  Bilirubin normal

          -  Partial thromboplastin time (PTT) and international normalized ratio (INR) normal

          -  Urine protein:creatinine ratio < 1.0

          -  Blood pressure ≤ 150/100 mm Hg on 3 separate occasions

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective contraception

          -  No significant recent hemoptysis (> ½ teaspoon of bright red blood)

          -  No unstable angina

          -  No New York Heart Association (NYHA) congestive heart failure ≥ class II

          -  No myocardial infarction or stroke within the past 6 months

          -  No clinically significant peripheral vascular disease

          -  No evidence of bleeding diathesis or coagulopathy

          -  No abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within
             the past 6 months

          -  No serious, non-healing wound, ulcer, or bone fracture

          -  No thrombosis requiring therapeutic anticoagulation

          -  No significant traumatic injury within the last 28 days

        PRIOR CONCURRENT THERAPY:

          -  Recovered from prior surgery

          -  At least 4 weeks since prior and no concurrent participation in another experimental
             drug study

          -  At least 4 weeks since prior and no concurrent major surgical procedure or open biopsy

          -  At least 2 weeks since prior mediastinoscopy or mediastinotomy

          -  At least 1 week since prior fine needle aspirations or core biopsies

          -  No other concurrent antineoplastic or antitumor agents, including chemotherapy,
             radiotherapy, immunotherapy, or hormonal anticancer therapy

          -  No other concurrent investigational agents