Clinical trial NCT00571116 (phase 1, status: terminated)
Conditions: metastatic melanoma
ICD codes: C43.0, C43.31, D03.9, C43.51, C43.9, D03.0, C43.4
Drugs: disulfiram, arsenic trioxide
SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC, O=[As]O[As]=O
Reason stopped: 
    halted because of slow accrual and lack of study funding
  
Eligibility criteria:

        Inclusion Criteria:

          -  Subjects must have bidimensionally measurable disease. All measurable lesions must be
             assessed (by physical examination, CT scan, radionuclide scan or plain X-ray) within
             28 days prior to registration. Non-measurable sites must be assessed within 42 days
             prior to registration. The subject's disease status must be completely assessed and
             reported.

          -  All subjects must undergo a CT of abdomen and chest within 28 days prior to
             registration.

          -  All subjects must undergo either a CT or MRI of the brain within 28 days of
             registration. Subjects with asymptomatic brain metastasis are eligible for this
             protocol but their metastasis must be clinically stable and asymptomatic. Subjects
             with Central Nervous System (CNS) metastasis must have been evaluated by neurosurgery
             prior to entry to confirm that they are a candidate for this trial. Treatment of
             symptomatic CNS metastasis that is required before protocol entry.

          -  Subjects must have progressed based on Response Evaluation Criteria in Solid Tumors
             (RECIST) criteria after at least one prior systemic therapy (chemotherapy,
             biologic/immunotherapy, or a combination regimen) for metastatic disease. This
             includes development of any new lesion or a 20% increase in the sum of the subject's
             measurable disease compared to their previous nadir. New CNS metastasis could be the
             reason for disease progression, but they must be stable clinically and satisfy
             criteria delineated in section 5.4. Prior systemic therapy must have been completed at
             least 28 days before registration.

          -  Subjects may have received prior biologic or immunotherapy given in an adjuvant
             fashion. Prior adjuvant therapy must have been completed at least 28 days prior to
             registration

          -  Subjects may have received prior radiation therapy. If all known sites of disease have
             been previously radiated, there must be objective evidence of progression for the
             subject to be eligible. Radiation therapy must have been completed at least 28 days
             before registration.

          -  Subjects may have received prior surgery. Prior surgery must have been completed at
             least 28 days before registration.

          -  Performance status must be 0-2 according to Southwest Oncology Group Criteria

        Performance Status:

        GRADE SCALE

        0 Fully active; able to carry on all pre-disease activities without restriction.

          1. Restricted in physically strenuous activity but ambulatory and able to carry out work
             of a light or sedentary nature, e.g., light housework, office work.

          2. Ambulatory and capable of all self care but unable to carry out any work activities.
             Up and about more than 50% of waking hours.

          3. Capable of only limited self care; confined to bed or chair more than 50% of waking
             hours.

          4. Completely disabled. Cannot carry on any self care. Totally confined to bed or chair.

          5. Dead

               -  Subjects must have a normal ECG, without evidence of congestive heart failure.

                    1. Normal heart rate (less than 100 per minute)

                    2. Normal sinus rhythm

                    3. Normal interval from the beginning of the Q wave to the termination of the S
                       wave, representing the time for ventricular depolarization (QRS) interval

                    4. Subjects with QT prolongation > 500msec on their ECG will be considered
                       ineligible.

                       Exclusion Criteria:

               -  Pregnant or nursing women are not eligible to participate in this trial because
                  the safe use of this drug in pregnancy has not been established.

               -  Subjects with severe myocardial disease or coronary occlusion, psychoses, and
                  hypersensitivity to disulfiram or other thiuram derivatives used in pesticides
                  and rubber vulcanization are excluded from the study.

               -  Subjects who can not abstain from alcohol intake during the entire duration of
                  this protocol are not qualified for this study.