Clinical trial NCT00411814 (phase 1, status: completed)
Conditions: asthma
ICD codes: J45.998, J82.83, J45.909, J45.991, J45.20, J45.30, J45.40
Drugs: gsk679586, placebo
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion criteria:

          -  Men aged 18 - 65 years inclusive, or women aged 18 - 50 years inclusive.

          -  Female subjects must be of non-childbearing potential,

          -  Male subjects must agree to abstain from sexual intercourse or use adequate
             contraception during sexual intercourse with pregnant or lactating females, in
             addition to their female partner using another form of contraception. This criterion
             must be followed from the time of the first dose of study medication until 84 days
             after the last dose of study medication.

          -  Body weight ≥ 50 kg and BMI within the range 19 - 29.9 kg/m2.

          -  Non-smoker as verified by urinary cotinine levels below 300 ng/mL at screening or
             ex-smokers who have given up smoking for >12 months with a history <10 pack years
             [Pack yrs = (No of cigarettes/day x No of years smoked)/20]

          -  Available to complete all study measurements.

          -  Able to read, comprehend, and write English at a sufficient level to complete study
             related materials.

          -  Capable of giving written informed consent, which includes compliance with the
             requirements and restrictions listed in the consent form

        Additional Inclusion Criteria for Subjects in Part I

        • Healthy as determined by a responsible physician, based on a medical evaluation including
        history, physical examination, laboratory tests, cardiac monitoring.

        Additional Inclusion Criteria for Subjects in Part II

          -  History of asthma for at least 6 months prior to the screening visit currently
             requiring no treatment or intermittent treatment with inhaled short-acting
             beta2-agonist only. Subject must not have received low dose inhaled corticosteroids
             within three months prior to Day 0.

          -  Pre-bronchodilator FEV1 >70% but <90% of predicted at screening with ≥12%
             reversibility after short-acting beta2-agonist or If the subject has a
             pre-bronchodilator FEV1 ≥90% at screening but has a history of asthma or if the
             subject meets the FEV1 criteria but does not demonstrate ≥12% reversibility after
             short-acting beta2-agonist administration, then the subject may be considered eligible
             if a Bronchial Provocation Test for asthma is positive (and after consultation with
             Medical Monitor and Principal Investigator). The bronchial provocation will be
             considered positive when the standard criteria for a positive response with the given
             challenge agent are met.

          -  Skin prick test positive for an allergen that is appropriate for nasal challenge

        Exclusion criteria:

          -  As a result of medical interview, physical examination or screening investigations,
             the responsible physician deemed the subject unsuitable for the study.

          -  History of sensitivity to any of the study medications, or components thereof or a
             history of drug or other allergy that, in the opinion of the physician responsible,
             contraindicates their participation.

          -  Previous exposure to humanised antibody therapy for any reason.

          -  A strong family history of Th1 cytokine-related inflammatory disorders, including but
             not limited to, Type I diabetes mellitus, multiple sclerosis, Crohn's disease,
             rheumatoid arthritis, sarcoidosis.

          -  Known history of active or latent tuberculosis, or recent (within 6 months of study
             enrolment) exposure to a person with active tuberculosis. Previous medical history and
             letter from the subject's physician (GP) should exclude this.

          -  A history of chronic urogenital infections or other chronic infections.

          -  Subjects who have received any type of vaccination in the last two months.

          -  The subject has participated in a clinical trial and has received a drug or a new
             chemical entity within 30 days or 5 half-lives, or twice the duration of the
             biological effect of any drug(whichever is longer) prior to the first dose of current
             study medication

          -  Where participation in study would result in donation of blood in excess of 500 mL
             within a 56 day period

          -  Exposure to more than four new chemical entities within 12 months prior to the first
             dosing day

          -  Use of prescription or non-prescription drugs, including vitamins, herbal and dietary
             supplements (including St John'sWort) within 7 days (or 14 days if the drug is a
             potential enzyme inducer) or 5 half-lives (whichever is longer) prior to the first
             dose of study medication, unless in the opinion of the Investigator and sponsor the
             medication will not interfere with the study procedures or compromise subject safety.

          -  History of alcohol/drug abuse or dependence within 12 months of the study:

          -  Abuse of alcohol defined as an average weekly intake of greater than 21 units or an
             average daily intake of greater than 3 units (males) or defined as an average weekly
             intake of greater than 14 units or an average daily intake of greater than 2 units
             (females). 1 unit is equivalent to a half-pint (220mL) of beer or 1 (25ml) measure of
             spirits or 1 glass (125ml) of wine

          -  A positive pre-study Hepatitis B surface antigen or positive Hepatitis C antibody
             result within 3 months of screening

          -  A positive test for human immunodeficiency virus (HIV) antibodies.

          -  The subject has a positive pre-study urine drug/ urine alcohol screen. A minimum list
             of drugs that will be screened for include Amphetamines, Barbiturates, Cocaine,
             Opiates, Cannabinoids and Benzodiazepines.

          -  ECG that is outside of ranges as defined by the protocol

          -  Those who, in the opinion of the Investigator, have a risk of non-compliance with
             study procedures.

          -  The subject has a history of confirmed or active parasitic infection.

          -  The subject is unable to refrain from travelling to countries with a high prevalence
             of infectious (especially parasitic) disease from when the first dose is administered
             until the expected washout period is complete (plasma levels below LLQ) or the last
             follow-up visit, which ever is later