Clinical trial NCT00062283 (phase 2, status: completed)
Conditions: lung cancer, malignant mesothelioma, pancreatic cancer, sarcoma
ICD codes: C78.00, C78.01, C78.02, D14.30, D14.31, D14.32, C34.2, C45.9, C45.0, C45.1, C45.2, C45.7, C25.3, C96.A, C46.9, C96.22, C46.0, C46.2, C92.31, C92.32
Drugs: l-alanosine
SMILES: N[C@@H](CN(O)N=O)C(O)=O
Eligibility criteria:

        DISEASE CHARACTERISTICS:

          -  Histologically or cytologically confirmed malignancy of any of the following types:

               -  Soft-tissue sarcoma

                    -  High grade

                    -  Chemotherapy naïve or progressive or metastatic after no more than 2 prior
                       cytotoxic treatment regimens (not including adjuvant therapy)

               -  Sarcoma of the bone (including osteosarcoma* and chondrosarcoma)

                    -  High grade

                    -  Progressive or recurrent after no more than 2 prior cytotoxic treatment
                       regimens

                    -  No newly diagnosed or chemotherapy naïve disease NOTE: *Prior treatment with
                       cisplatin and doxorubicin required

               -  Mesothelioma

                    -  Unresectable

                    -  Chemotherapy naïve or progressive after no more than 1 prior cytotoxic
                       chemotherapy regimen

                    -  Not amenable to curative treatment with surgery

                         -  Evidence of gross unresectability includes, but is not limited to,
                            direct extension into the chest wall, mediastinal or hilar
                            lymphadenopathy, pulmonary or cardiac function that is inadequate to
                            tolerate resection, and sarcomatoid or mixed histology

               -  Non-small cell lung cancer

                    -  Stage III with malignant pleural or pericardial effusion, stage IV, or
                       progressive after no more than 2 prior cytotoxic chemotherapy regimens

                    -  No newly diagnosed or chemotherapy naïve disease

               -  Pancreatic cancer

                    -  Stage IV adenocarcinoma after no more than 1 prior cytotoxic treatment
                       regimen

                    -  No newly diagnosed or chemotherapy naïve disease

          -  No Ewing's sarcoma of the soft tissue or bone

          -  Documented absence of methylthioadenosine phosphorylase on fixed tumor specimens

          -  Measurable disease

               -  For all tumor types, at least 1 lesion measurable by MRI or CT scan

               -  Chest x-ray allowed only for clearly defined lesions surrounded by aerated lung

               -  Soft tissue component of bone disease considered measurable provided it can be
                  measured by MRI or CT scan

               -  Must be outside of a previously irradiated area

          -  No uncontrolled CNS metastases of primary tumor under study

               -  Patients with brain metastases are eligible only if the brain metastases have
                  been treated with prior radiotherapy and/or surgery, are neurologically stable
                  with no progressing symptoms, and are off steroids and anticonvulsants

        PATIENT CHARACTERISTICS:

        Age

          -  18 and over (13 and over for osteosarcoma only)

        Performance status

          -  WHO 0-2

        Life expectancy

          -  At least 3 months

        Hematopoietic

          -  Absolute granulocyte count at least 1,500/mm^3

          -  Platelet count at least 100,000/mm^3

        Hepatic

          -  Bilirubin no greater than 1.5 times upper limit of normal (ULN)

          -  Alkaline phosphatase no greater than 2.5 times ULN

          -  AST and ALT no greater than 2.5 times ULN (5 times ULN if liver metastases are
             present)

        Renal

          -  Creatinine no greater than 1.5 times ULN

        Other

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective barrier contraception during and for 4 weeks after
             study treatment

          -  No premalignant bony lesions (e.g., Paget's disease)

          -  No other concurrent active malignancy except completely excised nonmelanoma skin
             cancer or carcinoma in situ of the cervix or bladder

          -  No serious infection

          -  No medical or psychiatric condition that would preclude the achievement of the study
             objectives

        PRIOR CONCURRENT THERAPY:

        Biologic therapy

          -  Not specified

        Chemotherapy

          -  See Disease Characteristics

          -  More than 42 days since prior nitrosoureas or mitomycin

        Endocrine therapy

          -  See Disease Characteristics

        Radiotherapy

          -  See Disease Characteristics

          -  At least 28 days since prior brain radiotherapy

          -  More than 28 days since prior radiotherapy to more than 50% of the bone marrow

        Surgery

          -  See Disease Characteristics

          -  At least 28 days since prior thoracic or other major surgery

        Other

          -  Recovered from prior therapy

          -  More than 28 days since prior cytotoxic agents

          -  More than 28 days since prior anticancer investigational agents

          -  No other concurrent anti-tumor treatment