Clinical trial NCT01254370 (phase 2, status: completed)
Conditions: glaucoma, ocular hypertension, ocular surface disease
ICD codes: H40.9, Q15.0, B73.02, H40.823, H40.89, H44.513, H40.821, H40.053, H40.051, H40.052, H40.059
Drugs: latanoprost, travatan z
SMILES: CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1, CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC1=CC=CC(=C1)C(F)(F)F
Eligibility criteria:

        Inclusion Criteria:

          -  Be at least 18 years of age at Visit 1 (IOP Screening), of either sex and any race or
             ethnicity.

          -  Be willing and able to provide written informed consent prior to any study procedures
             being performed.

          -  Be willing and able to follow all instructions and attend all study visits.

          -  Have a documented diagnosis of ocular hypertension, open angle glaucoma (with or
             without pseudoexfoliation or pigment dispersion component) or chronic angle closure
             glaucoma with a patent iridotomy requiring treatment with an ocular hypertensive
             therapy in the study eye.

          -  Agree to submit to a pregnancy test at Visit 1 and at Visit 4, or not be of
             childbearing potential.

          -  Agree to use an acceptable method of contraception for the duration of the study or
             not be of childbearing potential. Acceptable methods of birth control include:
             spermicide with barrier, oral, transdermal, injectable, or implantable contraception,
             IUD, abstinence, and surgical sterilization of partner. Female subjects are not of
             childbearing potential if they have had a hysterectomy, bilateral oophorectomy,
             bilateral tubal ligation, or are post-menopausal by at least 12 months.

        Exclusion Criteria:

          -  Have known sensitivity or poor tolerance to latanoprost or travoprost or any other
             component of the study medications.

          -  Have any form of glaucoma other than open angle glaucoma (with or without a pigment
             dispersion or pseudoexfoliation component), ocular hypertension or chronic angle
             closure glaucoma with patent iridotomy in either eye.

          -  Have an IOP at any time point during the Screening or Baseline visits (Visits 1 or 2)
             of > 34 mmHg in either eye.

          -  Be currently pregnant, nursing, or planning a pregnancy during the study period; or be
             a woman that has a positive pregnancy test.

          -  Have a history of any significant ocular condition(s) in either eye that would
             contraindicate the use of latanoprost or travoprost, or that might affect the study
             conduct or the interpretation of the study results.

          -  Have any abnormality preventing reliable Goldmann applanation tonometry of either eye.

          -  Have been previously non-responsive to prostaglandin analog therapy for reduction of
             IOP.

          -  Have prior (within 30 days of Visit 1) or anticipated concurrent use of an
             investigational drug or device during the study period.

          -  Have a condition or a situation, which in the Investigator's opinion, may put the
             subject at increased risk, confound study data, or interfere significantly with the
             subject's study participation.