Clinical trial NCT00109928 (phase 2, status: completed)
Conditions: lymphoma
ICD codes: S33.110S, S33.111S, S33.120S, S33.121S, S33.130S, S33.131S, S33.140S
Drugs: cisplatin, etoposide, gemcitabine, methylprednisolone
SMILES: [H][C@@]12N(C)C3=CC(OC)=C(C=C3[C@@]11CCN3CC=C[C@](CC)([C@@]13[H])[C@@]([H])(OC(C)=O)[C@]2(O)C(=O)OC)[C@]1(C[C@@]2([H])CN(CC(CC)=C2)CC2=C1NC1=CC=CC=C21)C(=O)OC, OCCOCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1, [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1, [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C
Eligibility criteria:

        DISEASE CHARACTERISTICS:

          -  Diagnosis of peripheral T-cell non-Hodgkin's lymphoma

               -  Newly diagnosed, relapsed or progressing disease after 1 prior treatment with a
                  non-platinum based chemotherapy (e.g., CHOP)

               -  Bulky stage II or stage III or IV disease

          -  The following histologies are not eligible:

               -  T-cell prolymphocytic leukemia

               -  T-cell large granular lymphocytic leukemia

               -  Any NK-cell leukemia

               -  Adult T-cell leukemia/lymphoma

               -  Mycosis fungoides/Sézary syndrome

               -  Lymphomatoid papulosis

               -  Nasal-type extranodal NK/T-cell lymphoma

               -  Enteropathy-type T-cell lymphoma

               -  Hepatosplenic T-cell lymphoma

               -  Subcutaneous panniculitis-like T-cell lymphoma

               -  Angioimmunoblastic T-cell lymphoma

               -  Primary cutaneous anaplastic large cell lymphoma (ALCL)

               -  ALCL with CD30, ALK, and EMA expression

                    -  ALCL morphology that fails to express ALK or EMA allowed provided T-cell
                       lineage is confirmed by immunotyping or genetic testing

          -  Bidimensionally measurable disease

          -  Adequate samples (e.g., core biopsies, especially multiple core biopsies) from the
             original diagnostic specimen available

               -  Needle aspiration or cytology is not considered adequate samples

          -  No clinical evidence of Central nervous system (CNS) involvement by lymphoma

        PATIENT CHARACTERISTICS:

        Age

          -  18 and over

        Performance status

          -  Zubrod 0-2

        Life expectancy

          -  Not specified

        Hematopoietic

          -  Absolute neutrophil count ≥ 1,500/mm^3

          -  Platelet count ≥ 100,000/mm^3

        Hepatic

          -  Bilirubin ≤ 2 times upper limit of normal

        Renal

          -  Creatinine clearance ≥ 30 mL/min

        Cardiovascular

          -  No history of congestive heart failure

          -  No history of myocardial infarction

          -  No history of unstable angina

          -  No history of asymptomatic arrhythmias

          -  Ejection fraction normal by multigated acquisition (MUGA) scan (for patients with
             questionable cardiac history)

          -  No other history of impaired cardiac status

        Other

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective contraception

          -  No known HIV positivity

          -  Mild clinical hearing loss allowed provided patient is willing to accept the potential
             for worsening of hearing loss

          -  No other malignancy within the past 5 years except adequately treated basal cell or
             squamous cell skin cancer or carcinoma in situ of the cervix

          -  Must have had a chest x-ray or CT scan of the chest and a CT scan of the abdomen and
             pelvis within the past 28 days

        PRIOR CONCURRENT THERAPY:

        Biologic therapy

          -  At least 3 weeks since prior biologic therapy

          -  No concurrent routine use of bone marrow colony-stimulating factors

        Chemotherapy

          -  No other concurrent chemotherapy

        Endocrine therapy

          -  Not specified

        Radiotherapy

          -  No prior radiotherapy for this cancer

          -  No concurrent radiotherapy

        Surgery

          -  Not specified

        Other

          -  No prior cytotoxic therapy for this cancer

          -  Concurrent enrollment in SWOG-8819 or SWOG-8947 allowed