Clinical trial NCT00393146 (phase 2, status: completed)
Conditions: arthritis, rheumatoid
ICD codes: M06.9, M05.9, M06.08, M06.00, M06.011, M06.012, M06.019
Drugs: gw856553
SMILES: CC1=C(C=C(C=C1F)C(=O)NC1CC1)C1=CC=C(C=N1)C(=O)NCC(C)(C)C
Eligibility criteria:

        Inclusion criteria:

          -  The subject is male or female ≥ 18 years of age.

          -  To be eligible, female subjects must have a negative pregnancy test (i.e. serum beta
             hCG test) and be of:

               1. non-childbearing potential (i.e. physiologically incapable of becoming pregnant).
                  This includes any female who is post-menopausal. For the purposes of this study,
                  post menopausal is defined as being amenorrhoeic for greater than 2 years with an
                  appropriate clinical profile, e.g. age appropriate, history of vasomotor
                  symptoms. Postmenopausal status will be confirmed by serum FSH and oestradiol
                  concentrations at screening. Surgical sterility will be defined as females who
                  have had a hysterectomy and/or bilateral oophorectomy or tubal ligation. OR

               2. childbearing potential and agrees to commit to one of the protocol-approved
                  methods of contraception as detailed in Section 7.1.

          -  Body weight ≥ 50 kg (110lbs) for males and ≥ 45 kg (99lbs) for females.

          -  Body mass index (BMI) within the range 18.5-35.0 kg/m2 inclusive.

          -  The subject has a diagnosis of RA according to the revised 1987 criteria of the
             American College of Rheumatology (ACR) (see Appendix 6).

          -  The subject must have DAS28 ≥ 4.2 (DAS28 calculated using ESR).

          -  The subject must have liver function (ALT, AST and total bilirubin) tests < 1.5 x ULN
             at screening.

          -  The subject must have ALP < 2 x ULN at screening.

          -  The subject must have normal serum folate levels at screening (folate supplements can
             be administered if required but this must be stable for 4 weeks prior to
             randomisation).

          -  The subject is able to understand and comply with protocol requirements, instructions
             and protocol-stated restrictions.

          -  Signed and dated written informed consent prior to admission to the study.

        Exclusion criteria:

          -  The subject has a three month prior history of regular alcohol consumption exceeding
             an average weekly intake of > 21 units (or an average daily intake of greater than 3
             units) for males, or an average weekly intake of > 14 units (or an average daily
             intake of greater than 2 units) for females. 1 unit is equivalent to a half-pint
             (284mL) of beer/lager; 25mL measure of spirits or 125mL of wine; or a positive alcohol
             breath test at the screening visit.

          -  The subject has any history of liver disease.

          -  The subject has a positive Hepatitis B surface antigen or Hepatitis C antibody result
             within 3 months of the start of the study.

          -  The subject has a history of elevated liver function tests on more than one occasion
             (ALT, AST, and total bilirubin > 2 x ULN or ALP > 3 x ULN) in the past 7 months.

          -  The subject is currently receiving a biological anti-rheumatic therapy.

          -  The subject has failed more than one anti-TNFα biological therapy due to lack of
             efficacy.

          -  The subject received an anti-rheumatic biological therapy within 6 months (for i.v.

        administered therapies with long half-lives e.g. infliximab) or 3 months (for
        subcutaneously administered therapies or iv administered therapies with short halflives
        e.g. adalimumab or etanercept) prior to randomisation.

          -  The subject has received rituximab.

          -  The subject is using oral prednisolone at doses > 10mg/day, methotrexate > 25 mg/week
             or sulphasalazine > 5g/day.

          -  The subject's DMARD dosing regimen has changed during the 4 weeks prior to
             randomisation.

          -  The subject's current DMARD regimen has changed significantly (i.e. likely to impact
             disease activity during the study period) within the 3 months prior to dosing e.g.
             addition of a DMARD, changes in dose of greater than 2.5mg for methotrexate.

          -  The subject has received leflunomide for less than 6 months prior to randomisation.

          -  The subject has failed more than 3 DMARDs.

          -  The subject's NSAIDs, COX-2 inhibitors or glucocorticoid dosing regimen changes at any
             time during four weeks prior to randomisation.

          -  The subject's statin dosing regimen has changed significantly during the 3 months
             prior to randomisation

          -  The subject has significant cardiac, pulmonary, metabolic, renal, hepatic or
             gastrointestinal conditions that, in the opinion of the investigator and/or GSK
             medical monitor, places the subject at an unacceptable risk as a participant in this
             trial.

          -  The subject has an acute infection or a history of repeated or chronic infections.

          -  The subject has a history of active tuberculosis.

          -  The subject has a history of malignancy, except for surgically cured basal cell
             carcinoma or females with cured cervical carcinoma (> 2 yrs prior).

          -  The subject has a history of HIV or other immunosuppressive disease.

          -  The subject has participated in a clinical trial within the 3 months prior to the
             study onset for non-biological therapy; or within 6 months of a biological therapy.

          -  The subject has Hb < 9 g/dL and platelet count < 150 000/mm3.

          -  The subject has a calculated creatinine clearance less than 60mL/min (subjects with a
             calculated creatinine clearance ≥ 50mL/min but < 60mL/min may still be included in
             consultation with the GSK medical monitor, but will not be eligible for the gadolinium
             enhancement MRI scans).

          -  The subject has uncontrolled diabetes or psoriasis.

          -  The subject has had a joint injection with glucocorticoid within the previous 4 weeks.

          -  The subject is pregnant or nursing.

          -  The subject is receiving medication which in the opinion of the investigator and/or
             GSK medical monitor, would interfere with study procedures, objectives or compromise
             subject safety.