Clinical trial NCT01362036 (phase 1, status: terminated)
Conditions: myelodysplastic syndrome (mds)
ICD codes: D46.Z, D46.9, C94.6, D46.C
Drugs: txa127
SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(O)=O
Reason stopped: 
    enrollment feasibility issues, new study in design
  
Eligibility criteria:

        Inclusion Criteria:

          -  Diagnosis of MDS using the World Health Organization classification and Low or
             Intermediate-1 risk MDS using the IPSS

          -  The mean of two platelet counts taken during the 2-week Screening Period must be ≤50 x
             109/L, with no individual non-transfused count >60 x 109/L. Platelet counts taken
             prior to Informed Consent may be used as one of the two counts taken within 2 weeks
             prior to study Day 1, but both counts must be obtained within 4 weeks of commencement
             of treatment.

          -  Subjects must be ≥18 years of age at the time of obtaining informed consent

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 at the time of
             screening

          -  Adequate Liver Function, as evidenced by a serum bilirubin ≤2 times the laboratory
             upper limit of normal (ULN) (except for patients with a confirmed diagnosis of
             Gilbert's Disease), ALT and/or AST ≤3 times the laboratory ULN.

          -  A serum creatinine concentration ≤2 mg/dL

        Exclusion Criteria:

          -  Currently receiving any treatment for MDS other than transfusions (last transfusion
             must be at least 4 weeks prior to treatment).

          -  If granulocyte and/or erythropoetic growth factors are currently being received, there
             should be a 4-week washout prior to treatment, and they may not be used during the
             study period.

          -  Concurrent active malignancy (other than controlled prostate cancer, in situ cervical
             cancer, or basal cell cancer of the skin)

          -  Prior history of bone marrow transplantation

          -  Unstable angina, uncontrolled congestive heart failure [NYHA > class II], uncontrolled
             hypertension [diastolic > 100 mmHg], uncontrolled cardiac arrhythmia, or recent
             (within 1 year) myocardial infarction, or a QTc interval value >450ms.

          -  Received Anti-Thymocyte Globuline (ATG) within 6 months of screening

          -  Received hypomethylating agents, immunomodulating agents, histone deacetylase
             inhibitors, cyclosporine, or mycophenolate within 4 weeks of start of treatment

          -  Received IL-11 (oprelvekin) within 4 weeks before screening

          -  Have ever previously received rTPO, PEG-rHuMGDF, eltrombopag, or romiplostim

          -  Less than 4 weeks since receipt of any investigational agent (not FDA approved, for
             any indication)

          -  History of arterial thrombosis (e.g., stroke or transient ischemic attack) in the past
             year

          -  History of venous thrombosis that currently requires anti-coagulation therapy

          -  Female subjects who are pregnant or breastfeeding. Women of childbearing potential are
             required to have a positive HCG serum or urine pregnancy test performed 7 days prior
             to first study drug dose

          -  Women of childbearing potential who are unwilling to use an adequate form of
             contraception during the course of the study.

          -  Subjects with current alcohol abuse, illicit drug use, or any other condition (e.g.,
             psychiatric disorder) that, in the opinion of the Investigator, may interfere with the
             patient's ability to comply with the study requirements or visit schedule.

          -  Subjects with a known sensitivity to any of the study medication components.

          -  Subjects known to have active HIV or known to be seropositive for HTLV-I.