Clinical trial NCT00674219 (phase 3, status: completed)
Conditions: obsessive-compulsive disorder, generalized anxiety disorder
ICD codes: F42.8, F42.9, F60.5, F41.1
Drugs: memantine
SMILES: CC12CC3CC(C)(C1)CC(N)(C3)C2
Eligibility criteria:

        Inclusion Criteria:

          -  The subject is male or female outpatient between 18-64 years old.

          -  The subject meets DSM-IV criteria for Generalized Anxiety Disorder or Obsessive
             Compulsive Disorder as determined by the MINI.

          -  Sexually active female patients of childbearing potential must be practicing at least
             one or more the following methods of contraception during the study: intrauterine
             device (IUD), barrier method in combination with a spermicide, oral/hormonal
             contraception or abstinence. Female patients of childbearing potential must have a
             negative pregnancy test prior to receiving study drug.

          -  Written informed consent must be obtained from the subject prior to study
             participation.

          -  The subject is in good medical health or with chronic medical conditions which are
             currently stable.

          -  No current abuse of alcohol or other substance.

          -  The subject has a total score of 20 or more on the HARS or YBOCS at screening (for GAD
             and OCD, respectively)

          -  The subject has a Clinical Global Impression (CGI) Severity score of 4 or more at
             screening.

        Exclusion Criteria:

          -  The subject meets DSM-IV criteria for an Axis I diagnosis (other than GAD or OCD) as
             the primary diagnosis (i.e., schizophrenia, mood disorder, psychosis, anorexia
             nervosa) as determined by the MINI.

          -  The subject is clinically judged by the investigator to be at risk for suicide or is
             acutely suicidal as objectively measured by the MINI and MSE.

          -  The subject is clinically judged by the investigator to be at risk for homicide or is
             acutely homicidal as objectively measured by the MINI and MSE.

          -  The subject has a psychiatric condition that would require inpatient, or partial
             psychiatric hospitalization.

          -  Seizure disorders.

          -  Significant history of medical disease (i.e. cardiovascular, hepatic (e.g. cirrhosis,
             hepatitis B or C) renal, gynecological, musculoskeletal, neurological,
             gastrointestinal, metabolic, hematological, endocrine, cancer with a metastatic
             potential or progressive neurological disorders) which could impair reliable
             participation in the trial or necessitate the use of medication not allowed by this
             protocol.

          -  The subject is pregnant, planning to become pregnant, or nursing. If a subject becomes
             pregnant, she will be discontinued immediately and followed appropriately.

          -  Concomitant therapy with another investigational drug, or participation in an
             investigational drug study within one month prior to entering this study.

          -  Current psychotherapeutic treatment except for treatment with Specific Reuptake
             Inhibitor (SSRIs) medications which include: Fluoxetine (Prozac), Paroxetine (Paxil),
             Sertraline (Zoloft), Luvox (Fluvoxamine), and Citalopram. Potential subjects may
             remain on one of the SSRI medications provided that he or she has been on a stable
             dose for at least 4 weeks prior to entering this study; this dose remains stable
             throughout the remainder of this study; and it can be determined that this medication
             is not exacerbating the anxiety symptoms.

          -  History of poor compliance or in the Investigator's judgment patients any subject
             whose treatment as an outpatient would be clinically contraindicated

          -  The subject has attempted suicide one or more times within the past twelve months

          -  The subject has a Structured Hamilton Depression Rating Scale (SIGH-D) score above 38
             which suggests a moderate to severe clinical level of depressive symptoms