Clinical trial NCT00090129 (phase 3, status: terminated)
Conditions: arthritis, psoriatic
ICD codes: L40.52
Drugs: onercept, placebo
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Reason stopped: 
    the risk-benefit ratio for the use of onercept in this condition was not sufficiently favorable
    to justify continued development
  
Eligibility criteria:

        Inclusion Criteria:

          -  Written informed consent, given prior to any study-related procedure not part of the
             subject's normal medical care, with the understanding that consent may be withdrawn by
             the subject at any time without prejudice to his or her future medical care

          -  At least 18 years of age

          -  Female subjects must be neither pregnant nor breast-feeding, and must lack
             childbearing potential, as defined by either:

               -  Being post-menopausal (that is at least 12 months passed last menses) or
                  surgically sterile, or

               -  Using an effective form of contraception (that is, condoms, oral contraceptives
                  or intrauterine device) (Confirmation that the subject is not pregnant must be
                  established by a negative urinary human chorionic gonadotrophin test within 7
                  days before Study Day 1. A pregnancy test is not required if the subject is
                  post-menopausal or surgically sterile)

          -  An out-patient status at the time of enrollment

          -  Plaque psoriasis for at least 12 months

          -  Plaque psoriasis covering at least 10 percent of total body surface area and a PASI
             score of 12.0 or more

          -  Candidate for phototherapy or systemic therapy

          -  Static Physician's Global Assessment (sPGA) of 3 or more

        Exclusion Criteria:

          -  Use of more than one Non-steroidal anti-inflammatory drug (NSAID) to treat psoriatic
             arthritis or having a change in chronic NSAID regimen during the 28 days before Study
             Day 1 to treat psoriatic arthritis

          -  Previous systemic treatment with biologics, including interferon, and/or
             cytokines/anti cytokines (for example, anti- tumor necrosis factor-alpha, anti-cluster
             of differentiation [CD]4, interleukin [IL]-10, IL-1ra, anti-CD11a, etc.) within 3
             months before Study Day 1

          -  Participation in any other investigational study or experimental therapeutic procedure
             considered to interfere with the study within 3 months before Study Day 1

          -  Treatment with any systemic corticosteroids or intra-articular corticosteroid
             injection during the 28 days before Study Day 1

          -  Experimental or off-label treatments for psoriasis and/or psoriatic arthritis such as
             azathioprine, hydroxyurea / hydroxycarbamide, mycophenolate, chlorambucil, leflunomide
             or cyclophosphamide within 1 year prior to Study Day 1

          -  Treatment with cyclosporin, methotrexate, oral retinoids (that is, acitretin), or
             fumaric acid esters within 28 days (3 months for acitretin) before Study Day 1

          -  Treatment with any topical therapies, such as Vitamin D derivatives, corticosteroids,
             tars and tar oils, dithranol for chronic or short contact therapy, salicylic acid and
             topical retinoids, within 14 days before Study Day 1

          -  Phototherapy within 28 days before Study Day 1

          -  Use of tanning booths within 14 days before Study Day 1

          -  Abnormal liver function, defined by a total bilirubin greater than or equal to 1.2
             times the upper limit of normal values, (except in the case of Gilbert's syndrome), or
             aspartate aminotransferase, alanine aminotransferase or alkaline phosphatase levels
             greater than or equal to 2.5 times the upper limit of normal values

          -  Inadequate bone marrow reserve, defined as:

               -  Leukocytes less than or equal to 3.5 * 10^9 per liter (/L), or

               -  Thrombocytes less than or equal to 100 * 10^9 /L, or

               -  Hemoglobin less than or equal to 5 millimole per liter (mmol/L) (8.9 gram per
                  deciliter).

          -  Abnormal renal function, defined by serum creatinine greater than 150 micromole per
             liter.

          -  Sero-positivity for human immunodeficiency virus (HIV), Hepatitis B surface antigen
             (HBsAg), or Hepatitis C virus (HCV)

          -  Planned major surgery within the treatment period of the study.

          -  History of cancer in the preceding 5 years (except adequately treated basal cell
             carcinoma of the skin or squamous cell carcinoma in situ of the skin). Any history of
             hematopoietic cancer

          -  History of active tuberculosis, current active tuberculosis or candidacy for
             prophylactic therapy for tuberculosis

          -  Active severe infection (or non-severe infection at the discretion of the
             Investigator).

          -  History of any opportunistic infection (for example, viral, fungal, protozoal, or
             bacterial) in the 6 months preceding Study Day 1 related to any clinical condition of
             immunodeficiency

          -  Clinically significant and serious abnormalities on electrocardiography or chest
             X-ray, (at the discretion of the Investigator)

          -  Other serious concomitant disorders incompatible with the study. In particular,
             subjects with congestive heart failure, prior or current history of blood dyscrasia or
             central nervous system demyelinating disorders should not be included in the study

          -  History of or current drug (including narcotics) abuse, or current active problems
             with alcohol abuse

          -  Requirement for immunization, allergy desensitization or vaccination during the entire
             study period (it is recommended that these procedures be scheduled at least 14 days
             prior to Study Day 1 or greater than 3 months after the last injection of study drug),
             with the exception of killed influenza vaccines which are allowed at any time during
             the study

          -  Guttate, erythrodermic or pustular psoriasis as sole or predominant form of psoriasis.

          -  Evidence of skin conditions other than psoriasis (for example, eczema) that would
             interfere with psoriasis disease assessments

          -  Clinically significant psoriasis flares during screening or at the time of enrollment
             necessitating immediate relief (at the Investigator's discretion)

          -  Live or killed virus or bacteria vaccines (within 14 days before Study Day 1) with the
             exception of killed influenza vaccines which are allowed both prior to Study Day 1 and
             at any time during the study

          -  Bedridden status

          -  Previous use of onercept