Clinical trial NCT00460174 (phase 2, status: completed)
Conditions: pancreatic cancer
ICD codes: C25.3
Drugs: gemcitabine
SMILES: [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1
Eligibility criteria:

        DISEASE CHARACTERISTICS:

          -  Diagnosis of localized pancreatic cancer

               -  No metastatic disease

          -  Resectable or unresectable tumor based on spiral CT with both oral and intravenous
             contrast enhancement, defined by the following National Comprehensive Cancer Network
             (NCCN) criteria for resectability*:

               -  Resectable tumors meeting the following criteria:

                    -  No distant metastases

                    -  Clear fat plane around celiac and superior mesenteric arteries

                    -  Patent superior mesenteric vein/portal vein

               -  Tumors considered borderline resectable according to NCCN criteria, including any
                  of the following, are considered unresectable for the purpose of this study:

                    -  Severe unilateral superior mesenteric vein/portal impingement

                    -  Tumor abutment on the superior mesenteric artery

                    -  Gastroduodenal artery encasement up to the origin at the hepatic artery

                    -  Colon invasion NOTE: *Determination of resectability must be made prior to
                       study entry based on NCCN criteria

          -  Patients with biliary or gastroduodenal obstruction must have drainage or surgical
             bypass prior to starting chemoradiotherapy

          -  Radiographically assessable disease

               -  Malignant disease must be encompassable within a single irradiation field

          -  No gross duodenal invasion noted on endoscopy

          -  No CNS or brain metastases

        PATIENT CHARACTERISTICS:

          -  ECOG performance status 0-1

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective contraception during and for up to 3 months after
             completion of study therapy

          -  Bilirubin ≤ 2.0 mg/dL

          -  AST or ALT ≤ 2.5 times upper limit of normal

          -  Urine protein:creatinine ratio < 1.0

          -  Proteinuria < 2+ by dipstick urinalysis OR baseline protein ≤ 1 g/24-hour urine
             collection

          -  Absolute neutrophil count ≥ 1,500/mm³

          -  Platelet count ≥ 100,000/mm³

          -  Hemoglobin ≥ 9.0 g/dL (transfusion or epoetin alfa support allowed)

          -  INR ≤ 1.5

          -  No other malignancy within the past 5 years except nonmelanomatous skin cancer or
             carcinoma in situ of the cervix, uterus, or bladder

          -  No concurrent significant infection or other medical condition that would preclude
             protocol treatment

          -  No history of other disease, metabolic dysfunction, physical examination finding, or
             clinical laboratory finding that would contraindicate use of an investigational drug,
             affect the interpretation of the results of the study, or render the patient at high
             risk for treatment complications

          -  No clinically significant cardiac disease, including any of the following:

               -  Uncontrolled hypertension (i.e., blood pressure > 150/100 mm Hg despite
                  antihypertensive medication)

               -  Myocardial infarction within the past year

               -  Unstable angina

               -  New York Heart Association class II-IV congestive heart failure

               -  Unstable symptomatic arrhythmia requiring medication

                    -  Chronic atrial arrhythmia (i.e., atrial fibrillation or paroxysmal
                       supraventricular tachycardia) allowed

          -  No clinically significant peripheral vascular disease

          -  No evidence of bleeding diathesis or coagulopathy

          -  No significant traumatic injury within the past 28 days

          -  No serious, nonhealing wound or ulcer, or concurrent healing fracture

          -  No history of aneurysm, stroke, transient ischemic attack, or arteriovenous
             malformation

          -  No abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within
             the past 6 months

        PRIOR CONCURRENT THERAPY:

          -  See Disease Characteristics

          -  No prior treatment for pancreatic cancer

          -  More than 5 years since prior chemotherapy for malignancies other than pancreatic
             cancer

          -  No prior radiotherapy to the target volume

          -  More than 28 days since prior major surgical procedure or open biopsy

          -  At least 28 days since prior surgical bypass

          -  More than 7 days since prior fine-needle aspiration or core biopsy

          -  No prior organ transplant

          -  At least 4 weeks since prior sorivudine or brivudine

          -  At least 30 days since prior cimetidine

          -  No concurrent major surgical procedure