araag2/HINT huggingface dataset:
Clinical trial NCT02525874 (phase 3, status: completed)
Conditions: multiple sclerosis, relapsing-remitting, multiple sclerosis
ICD codes: G35, G93.81, K74.1, Q85.1, G12.21, G12.23, M34.0, G35, C81.18
Drugs: dimethyl fumarate
SMILES: [H]\C(=C(\[H])C(=O)OC)C(=O)OC
Eligibility criteria:

        Key Inclusion Criteria:

          -  Subjects of childbearing potential (including female subjects who are post-menopausal
             for less than 1 year) must practice effective contraception during the study and be
             willing and able to continue contraception for 30 days after their last dose of study
             treatment.

          -  Must have a confirmed diagnosis of RRMS according to the revised McDonald criteria
             (2010) [Polman 2011]

        Key Exclusion Criteria:

          -  History of or positive test result at Screening for:

          -  human immunodeficiency virus

          -  hepatitis C virus antibody

          -  hepatitis B infection

          -  Drug or alcohol abuse within 1 year prior to Screening.

          -  Prior treatment with any of the following:

          -  cladribine

          -  mitoxantrone

          -  total lymphoid irradiation

          -  alemtuzumab

          -  T-cell or T-cell receptor vaccination

          -  any therapeutic monoclonal antibody, with the exception of natalizumab or daclizumab

          -  Treatment with any of the following medications or procedures within 6 months prior to
             Baseline (Day 1):

          -  DMF (given as Fumaderm®) or BG00012; enrollment will be limited to no more than 40
             subjects (out of 200) with prior DMF exposure

          -  cyclosporine

          -  azathioprine

          -  methotrexate

          -  mycophenolate mofetil

          -  intravenous (IV) Ig

          -  plasmapheresis or cytapheresis

        NOTE: Other protocol defined Inclusion/Exclusion criteria may apply
Clinical trial NCT02531035 (phase 3, status: completed)
Conditions: type 1 diabetes mellitus (t1dm), high level of sugar (glucose) in the blood
ICD codes: E23.2, N25.1, P70.2, O24.92, Z83.3, Z86.32, E10.65
Drugs: sotagliflozin, placebo
SMILES: CCOC1=CC=C(CC2=CC(=CC=C2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)C=C1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Participants had given written informed consent to participate in the study in
             accordance with local regulations

          -  Adult participants 18 years and older with a diagnosis of T1DM made at least 1 year
             prior to informed consent

          -  Participants were being treated with insulin or insulin analog

          -  Willing and able to perform self-monitoring of blood glucose (SMBG) and complete the
             study diary as required per protocol

          -  At the Screening Visit, A1C was between 7.0% to 11.0%

          -  Females of childbearing potential used an adequate method of contraception and had a
             negative pregnancy test

        Exclusion Criteria:

          -  Use of antidiabetic agent other than insulin or insulin analog at the time of
             screening

          -  Use of sodium-glucose cotransporter (SGLT) inhibitors within 8 weeks prior to
             screening

          -  Chronic systemic corticosteroid use

          -  Type 2 diabetes mellitus (T2DM), or severely uncontrolled T1D as determined by the
             Investigator
Clinical trial NCT02531438 (phase 3, status: completed)
Conditions: bacterial pneumonia, community-acquired infections
ICD codes: J15.9, P23.6
Drugs: omadacycline, moxifloxacin
SMILES: [H][C@@]12CC3=C(C=C(CNCC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@@H](N(C)C)[C@]1([H])C2)N(C)C, [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Eligibility criteria:

        Inclusion Criteria:

          -  Patients, ages 18 years or older who have signed the informed consent

          -  Has qualifying bacterial pneumonia

          -  Female patients must not be pregnant at the time of enrollment

          -  Must agree to a reliable method of birth control during the study and for 30 days
             following the last dose of study drug

        Exclusion Criteria:

          -  Known or suspected hospital-acquired pneumonia

          -  Evidence of significant immunological disease

          -  Has a history of hypersensitivity or allergic reaction to any tetracycline or to any
             fluoroquinolone antibiotic

          -  Has received an investigational drug within past 30 days

          -  Women who are pregnant or nursing
Clinical trial NCT02544451 (phase 3, status: completed)
Conditions: cystic fibrosis
ICD codes: E84.9, Z14.1, E84.0, E84.11, E84.8, E84.19, P09.4
Drugs: lum/iva
SMILES: CC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)C
Eligibility criteria:

        Inclusion Criteria:

        Subjects entering the Treatment Cohort must meet both of the following criteria:

          -  Completed study visits up to Week 24 of Study 109 or Week 26 of Study 011B and did not
             permanently discontinue treatment

          -  Willing to remain on a stable CF medication through the Safety Follow-up Visit.

        Subjects entering the Observational Cohort must meet 1 of the following criteria:

          -  Completed 24 weeks of study drug treatment in Study 109 or completed 24 weeks of study
             drug treatment and the Week 26 Safety Follow up in Study 011B.

          -  Received at least 4 weeks of study drug and completed visits up to Week 24 of Study
             109 or Week 26 of Study 011B.

        Exclusion Criteria (Treatment Cohort Only):

          -  History of any comorbidity or laboratory abnormality that, in the opinion of the
             investigator, might confound the results of the study or pose an additional risk in
             administering study drug to the subject (e.g., cirrhosis with portal hypertension).

          -  Pregnant and nursing females.

          -  Sexually active subjects of reproductive potential who are not willing to follow the
             contraception requirements.

          -  History of drug intolerance in the prior study that would pose an additional risk to
             the subject in the opinion of investigator

          -  History of poor compliance with study drug and/or procedure in the previous study as
             deemed by the investigator.

          -  Participation in an investigational drug trial (including studies investigating
             lumacaftor and/or ivacaftor).
Clinical trial NCT02544763 (phase 3, status: completed)
Conditions: tuberous sclerosis complex, seizures
ICD codes: G35, G93.81, K74.1, Q85.1, G12.21, G12.23, M34.0, G40.89, R56.1, F44.5, G40.501, G40.509, G40.111, G40.119
Drugs: gwp42003-p, placebo
SMILES: CCCCCC1=CC(O)=C([C@@H]2C=C(C)CC[C@H]2C(C)=C)C(O)=C1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Key Inclusion Criteria:

          -  Participant has a well-documented clinical history of epilepsy.

          -  Participant has a clinical diagnosis of Tuberous Sclerosis Complex (TSC) according to
             the criteria agreed by the 2012 International TSC Consensus Conference.

          -  All medications or interventions for epilepsy (including ketogenic diet and any
             neurostimulation devices for epilepsy) must have been stable for 1 month prior to
             screening and the participant is willing to maintain a stable regimen throughout the
             trial.

        Key Exclusion Criteria:

          -  Participant has a history of pseudo-seizures.

          -  Participant has clinically significant unstable medical conditions other than
             epilepsy.

          -  Participant has an illness in the 4 weeks prior to screening or randomization, other
             than epilepsy, which in the opinion of the investigator could affect seizure
             frequency.

          -  Participant has undergone general anesthetic in the 4 weeks prior to screening or
             randomization.

          -  Participant has undergone surgery for epilepsy in the 6 months prior to screening.

          -  Participant is being considered for epilepsy surgery or any procedure involving
             general anesthesia.

          -  Participant has been taking felbamate for less than 1 year prior to screening.

          -  Participant is taking an oral mTOR inhibitor.

          -  Participant has any known or suspected hypersensitivity to cannabinoids or any of the
             excipients of the Investigational Medicinal Product (IMP), such as sesame oil.

          -  Participant has any history of suicidal behavior or any suicidal ideation of type 4 or
             5 on the C-SSRS in the last month or at screening.

          -  Participant is currently using or has in the past used recreational or medicinal
             cannabis, or cannabinoid-based medications, within the 3 months prior to screening and
             is unwilling to abstain for the duration for the study.

          -  Participant has tumor growth which, in the opinion of the Investigator, could affect
             the primary endpoint.

          -  Participant has significantly impaired hepatic function at the screening or
             randomization visit

          -  Participant has received an IMP within the 12 weeks prior to the screening visit.
Clinical trial NCT02545504 (phase 3, status: completed)
Conditions: gastric adenocarcinoma
ICD codes: C22.0, C22.1, C4A.9, C7B.1, D09.9, C4A.0, C4A.31
Drugs: andecaliximab, placebo, leucovorin, 5-fluorouracil, oxaliplatin
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1, FC1=CNC(=O)NC1=O, [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1
Eligibility criteria:

        Key Inclusion Criteria:

          -  Adults with histologically confirmed adenocarcinoma of the stomach or gastroesophageal
             junction that is inoperable, locally advanced or metastatic and not amenable to
             curative therapy

          -  Adequate hematologic, liver, coagulation and kidney function

          -  Eastern Cooperative Oncology Group (ECOG) ≤ 1

          -  Evaluable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v 1.1

        Key Exclusion Criteria:

          -  Previous chemotherapy for locally advanced or metastatic gastric cancer.

          -  Human Epidermal Growth Factor Receptor 2 (HER2)-positive gastric cancer

          -  HIV, hepatitis B virus (HBV), or hepatitis C virus (HCV) infection

          -  Pregnant or breast feeding women

          -  Individuals with known or suspected central nervous system metastases or individuals
             requiring chronic daily treatment with oral corticosteroids

          -  Grade ≥ 2 peripheral neuropathy

        Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Clinical trial NCT02549417 (phase 3, status: completed)
Conditions: secondary hyperparathyroidism
ICD codes: E21.1, N25.81
Drugs: khk7580
SMILES: C[C@@H](N[C@H]1CCN(C1)C1=CC=C(CC(O)=O)C=C1)C1=C2C=CC=CC2=CC=C1
Eligibility criteria:

        Inclusion Criteria:

          -  Personally submitted written voluntary informed consent to participate in the study

          -  Stable chronic renal disease treated with peritoneal dialysis for at least 16 weeks
             before screening

          -  Intact PTH level of > 240 pg/ml at screening

        Exclusion Criteria:

          -  Treatment with cinacalcet hydrochloride within 2 weeks before screening;

          -  Change in dose or dosing regimen of an activated vitamin D drug or its derivative,
             phosphate binder, or calcium preparation within 2 weeks before screening; or start of
             treatment with such drugs within 2 weeks before screening;

          -  Parathyroidectomy and/or parathyroid intervention within 24 weeks before screening;

          -  Severe heart disease;

          -  Severe hepatic dysfunction;

          -  Uncontrolled hypertension and/or diabetes;

          -  Treatment with an investigational product (drug or medical device) in a clinical study
             or any study equivalent to clinical study within 12 weeks before screening;

          -  Primary hyperparathyroidism;

          -  Other conditions unfit for participation in this study at the discretion of the
             investigator or subinvestigator.
Clinical trial NCT02550665 (phase 3, status: completed)
Conditions: alzheimer's disease
ICD codes: G30.8, G30.9, G30.0, G30.1
Drugs: donepezil
SMILES: O=S(=O)(C1=CC=CC=C1)C1=CN=C2C(C=CC=C2N2CCNCC2)=C1
Eligibility criteria:

        Inclusion Criteria:

          -  dementia according to Diagnostic and Statistical Manual of Mental Disorders (DSM)-IV
             criteria

          -  probable Alzheimer's disease dementia according to National Institute on
             Aging-Alzheimer's Association (NIAAA) criteria

          -  Mini-Mental State Examination (MMSE) score of 20 or less

          -  General Deterioration Scale (GDS) score of 4 or more / Clinical Dementia Rating (CDR)
             score of 2 or more

          -  stable dose of 10mg donepezil at least 3 months before screening

          -  caregiver who can come together at every visit and give informations about side
             effects profiles should exist

          -  patients and caregivers accepted the study

        Exclusion Criteria:

          -  patients receiving other concomitant acetylcholinesterase inhibitor

          -  uncontrolled psychiatric disorders

          -  drug overuse or alcohol abuse history within 5 years

          -  significant uncontrolled or active medical conditions

          -  uncontrolled epilepsy

          -  patients who cannot come at scheduled visits
Clinical trial NCT02551874 (phase 3, status: completed)
Conditions: type 2 diabetes mellitus
ICD codes: E11.65, E11.9, E11.21, E11.36, E11.41, E11.42, E11.44
Drugs: saxagliptin, onglyza, dapagliflozin, farxiga, glargine insulin, metformin
SMILES: N[C@H](C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N)C12CC3CC(CC(O)(C3)C1)C2, CCOC1=CC=C(CC2=C(Cl)C=CC(=C2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)C=C1, [Na+].[Na+].[O-]P([O-])(F)=O, CSCC[C@H](N)C(O)=O
Eligibility criteria:

        For more information regarding BMS clinical trial participation, please visit
        www.BMSStudyConnect.com

        Inclusion Criteria:

          -  At least 18 years of age at screening

          -  HbA1c ≥ 8% and ≤ 12% at screening

          -  Fasting plasma glucose (FPG) ≤ 270 mg/dL (15mmol/L)

          -  Stable dose metformin ≥ 1500 mg per day with or without a stable dose of sulfonylurea
             (defined as at least 50% maximal dose per local label) for at least 8 weeks

          -  estimated glomerular filtration rate (eGFR) &lt; 60 ml/ml/1.73m2

          -  Body Mass Index ≤ 45.0 kg/m2

        Exclusion Criteria:

          -  Clinical diagnosis of Type 1 diabetes

          -  History of ketoacidosis

          -  Renal, hepatic or pancreatic disease

          -  Impairment of renal function (defined as creatinine clearance [CrCl] < 60 mL/min

          -  Cardiovascular or vascular diseases identified within 3 months of
             participationImpairment of renal function (defined as creatinine clearance [CrCl] < 60
             mL/min
Clinical trial NCT02553772 (phase 3, status: completed)
Conditions: dry eye syndromes
ICD codes: H04.121, H04.122, H04.123, H04.129
Drugs: carboxymethylcellulose based eye drop, carboxymethylcellulose sodium 0.5%
SMILES: OCC(O)CO
Eligibility criteria:

        Inclusion Criteria:

          -  Used artificial tears for dry eye

          -  Visual acuity of at least 20/32 (while wearing glasses, if necessary).

        Exclusion Criteria:

          -  Use of contact lenses in the last 3 months, or anticipated use of contact lenses
             during the study

          -  Herpes keratitis in the last 6 months

          -  Cataract surgery, laser-assisted in situ keratomileusis [LASIK], or photorefractive
             keratectomy, within the last 6 months
Clinical trial NCT02555215 (phase 3, status: completed)
Conditions: multiple sclerosis, relapsing-remitting
ICD codes: G35, G93.81, K74.1, Q85.1, G12.21, G12.23, M34.0
Drugs: dimethyl fumarate
SMILES: [H]\C(=C(\[H])C(=O)OC)C(=O)OC
Eligibility criteria:

        Key Inclusion Criteria:

          -  Ability of parents, legal guardians, and/or subjects to understand the purpose and
             risks of the study and provide signed and dated informed consent and authorization to
             use confidential health information in accordance with national and local subject
             privacy regulations. Subjects will provide assent in addition to the parental or
             guardian consent, as appropriate, per local regulations.

          -  Subjects who completed, as per protocol, the previous BG00012 clinical study 109MS202
             (NCT02410200) and remain on BG00012 treatment.

        Key Exclusion Criteria:

          -  Unwillingness or inability to comply with study requirements, including the presence
             of any condition (physical, mental, or social) that is likely to affect the subject's
             ability to comply with the protocol.

          -  Any significant changes in medical history occurring after enrollment in the parent
             Study 109MS202 (NCT02410200), including laboratory test abnormalities or current
             clinically significant conditions that in the opinion of the Investigator would have
             excluded the subject's participation from the parent study. The Investigator must
             re-review the subject's medical fitness for participation and consider any factors
             that would preclude treatment.

          -  Subjects from Study 109MS202 (NCT02410200) who could not tolerate study treatment.

        NOTE: Other protocol defined inclusion/exclusion criteria may apply.
Clinical trial NCT02555657 (phase 3, status: completed)
Conditions: metastatic triple negative breast cancer
ICD codes: C79.81, D24.1, D24.2, D24.9, D49.3, C44.501, D48.60
Drugs: capecitabine, eribulin, gemcitabine, vinorelbine
SMILES: [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1, [H][C@@]12O[C@@]3([H])CCC4CC(=O)C[C@H]5[C@H](C[C@H]6O[C@H](C[C@@H](C)C6=C)CC[C@@H]6O[C@H](CC6=C)CC[C@@]67C[C@@H](O[C@H]1[C@@H](O6)[C@@]3([H])O4)[C@@H]2O7)O[C@H](C[C@H](O)CN)[C@@H]5OC, [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1, [H][C@@]12N(C)C3=CC(OC)=C(C=C3[C@@]11CCN3CC=C[C@](CC)([C@@]13[H])[C@@]([H])(OC(C)=O)[C@]2(O)C(=O)OC)[C@]1(C[C@@]2([H])CN(CC(CC)=C2)CC2=C1NC1=CC=CC=C21)C(=O)OC
Eligibility criteria:

        Inclusion Criteria:

          -  Centrally confirmed Stage IV/M1 mTNBC

          -  Newly obtained tumor biopsy from metastatic site

          -  Central determination of programmed cell death ligand 1 (PD-L1) tumor status

          -  Received either one or two prior systemic treatments for metastatic breast cancer and
             have documented disease progression on or after the most recent therapy

          -  Previously treated with an anthracycline and/or taxane in the neoadjuvant/adjuvant or
             metastatic setting

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 within 10 days
             prior to study start

          -  Adequate organ function

        Exclusion Criteria:

          -  Participation in another clinical trial within 4 weeks

          -  Monoclonal antibody (mAb) for direct anti-neoplastic treatment within 4 weeks

          -  Chemotherapy, targeted small molecule therapy, or radiation therapy within at least 2
             weeks

          -  Active autoimmune disease that required systemic treatment in the past 2 years

          -  Diagnosed with immunodeficiency or receiving systemic steroid therapy or another form
             of immunosuppressive therapy within 7 days

          -  Known additional malignancy that required treatment or progressed in last 5 years

          -  Known active brain metastases and/or carcinomatous meningitis

          -  Prior therapy with an anti-programmed cell death (PD)-1, anti-PD-ligand-1
             (anti-PD-L1), anti-PD-L2 agent or with an agent directed to another co-inhibitory
             T-cell receptor (e.g. cytotoxic T-lymphocyte associated protein 4 [CTLA-4], OX-40,
             CD137) or previously participated in any pembrolizumab (MK-3475) clinical studies
Clinical trial NCT02555878 (phase 3, status: completed)
Conditions: neoplasms
ICD codes: C05.2, C10.0, C16.0, C16.4, C17.0, C17.1, C17.2
Drugs: rivaroxaban, placebo
SMILES: ClC1=CC=C(S1)C(=O)NC[C@H]1CN(C(=O)O1)C1=CC=C(C=C1)N1CCOCC1=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Have histologically confirmed solid malignancy including but not limited to: pancreas,
             lung, stomach, colon, rectum, bladder, breast, ovary, renal or lymphoma (hematologic),
             with locally advanced or metastatic disease

          -  Have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2

          -  Have a Khorana thromboembolic risk Score greater than or equal to (>=) 2

          -  Creatinine clearance (CrCl) >= 30 milliliter per minute (mL/min)

          -  Plan to initiate systemic cancer therapy within plus or minus (+-) 1 week of receiving
             the first dose of study drug with the intention of receiving systemic cancer therapy
             during the double-blind treatment period for an intended duration determined by the
             treating oncologist according to standard protocols of clinical care

        Exclusion Criteria:

          -  Diagnosis of primary brain tumors

          -  Known history of brain metastases

          -  Bleeding diathesis, hemorrhagic lesions, active bleeding, and other conditions with a
             high risk for bleeding

          -  Hematologic malignancies with the exception of lymphoma

          -  Platelet count less than (<) 50,000/millimeter^3 (mm^3), Life expectancy of less than
             or equal to (<=) 6 months