Clinical trial NCT02749526 (phase 2, status: terminated)
Conditions: esophageal
ICD codes: K22.2, K22.81, Q39.4, P78.83, I85.00, I85.01, I85.10
Drugs: "endostar", liposo, cisplatin, gimeracil and oteracil potassium （tegafur）
SMILES: [H][C@@]12N(C)C3=CC(OC)=C(C=C3[C@@]11CCN3CC=C[C@](CC)([C@@]13[H])[C@@]([H])(OC(C)=O)[C@]2(O)C(=O)OC)[C@]1(C[C@@]2([H])CN(CC(CC)=C2)CC2=C1NC1=CC=CC=C21)C(=O)OC, OC1=CC(=O)NC=C1Cl
Reason stopped: 
    low accrual rate
  
Eligibility criteria:

        Inclusion Criteria:

          -  patients with esophageal cancer confirmed by histology or cytology;

          -  according to TNM staging for Ⅲ period, previous untreated can be removed and
             potentially resectable esophageal cancer patients;

          -  can eat more than liquid diet;No signs before esophageal perforation;No distant
             metastasis;

          -  male or female, age 18 and 75 years old or less or more;

          -  ECOG PS 0 ~ 1 minute;

          -  is expected to survive period for 3 months or more,

          -  enough blood function: absolute neutrophil count (ANC) or 2 x 109 / L and the •
             platelet count 100 x 109 / L or higher acuity 9 g/dL and hemoglobin;Liver function

          -  enough: upper limit of total bilirubin acuities were normal (ULN);AST and ALT acuities
             were 2.5 times the upper limit of normal (ULN);Alkaline phosphatase 5 times the upper
             limit of normal or less (ULN);

          -  enough renal function, serum creatinine or less normal limit (ULN) or calculated
             creatinine clearance or 60 mL/min.

          -  basic normal ecg, no healing trauma;

          -  always not received anti-tumor drug treatment;

          -  ever had had surgery patients, request to study treatment began to have more than 4
             weeks, and the patient has recovered;

          -  a complete uterus of female in the group within 28 days before the study must have a
             negative pregnancy test results (except amenorrhea has 24 months).If the pregnancy
             test from the first time for more than 7 days, is the need for urine pregnancy test
             validation (within 7 days before the first delivery).

          -  prior to biological agents, especially e. coli genetically engineered products without
             severe allergic reactions;

        Exclusion Criteria:

          -  there is a clear taxol allergy history;

          -  pregnancy, nursing mothers, or have fertility but not women using contraception;

          -  the existing serious acute infection, and not be controlled;Or fester sex and chronic
             infection, wound in delay no more;

          -  the original serious heart disease, including: higher risk of congestive heart
             failure, unable to control arrhythmia, unstable angina, myocardial infarction, severe
             valvular heart disease, and resistant hypertension;

          -  is not easy to control nerve, mental illness or mental disorders, compliance is poor,
             can't cooperate with accounts and response to treatment;Primary brain tumors or CNS
             metastases illness did not get a control, has obvious symptoms in cranial hypertension
             or nerve spirit;

          -  with bleeding tendency;