Clinical trial NCT02034292 (phase 1, status: terminated)
Conditions: acute coronary syndrome
ICD codes: I24.0
Drugs: clopidogrel, aspirin, apd791, placebo
SMILES: N[C@@H](CCCNC(N)=N)C(O)=O, CC(=O)OC1=CC=CC=C1C(O)=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Reason stopped: 
    sponsor decision
  
Eligibility criteria:

        Inclusion Criteria:

          1. a healthy adult between 20 and 45 years old at the time of visit for screening

          2. a person who is able to give written consent

          3. a person between 50 and 85 kg at the time of visit for screening

          4. a woman who is negative on a serum hCG test at the time of visit and the day before a
             trial, and who is not nursing

          5. a woman who agrees on double contraception, medically approved, from the time of visit
             for screening to 90 days after the last administration of a clinical trial drug, or
             who had a contraceptive operation no later than 120 days before visit for screening,
             or who is menopausal

          6. a man who had a contraceptive operation no later than 120 days before visit for
             screening, or who agrees on double contraception, medically approved, from the time of
             visit for screening to 90 days after the last administration of a clinical trial drug,
             and also agree not to donate sperm

          7. a person more than hemoglobin 12 g/dL at the time of screening (a woman more than
             hemoglobin 11 g/dL)

          8. a person whose vital signs were in the normal range at the time of visit for
             screening, or who is medically determined not to be clinically significant by an
             investigator

          9. a person who voluntarily decides to participate in this clinical trial and gives
             written consent on strict clinical trial compliance

         10. a person whose blood can be collected during a study period with visit for monitoring

        Exclusion Criteria:

          1. a person with the medical history of gastric ulcer, duodenal ulcer or esophageal ulcer
             within 90 days from the time of visit for screening

          2. a person with the medical history of gastrointestinal diseases(e.g. Crohn's disease,
             ulcerative colitis, etc.) or surgery(excluding uncomplicated appendectomy or
             herniotomy) affecting the absorption of a clinical trial drug

          3. a person with the medical history of blood coagulation disorder or hemorrhagic
             diseases, or with clinically significant abnormal findings decided by a investigator
             on blood coagulation test at the time of screening

          4. a woman with the medical history of dysfunctional uterine bleeding within a year from
             the time of visit for screening

          5. a person with the medical history of epilepsy or convulsion

          6. a person with the medical history of internal organ transplant

          7. a person expected to be hard to complete a clinical trial because of surgery or
             medical procedures planned within a clinical trial period

          8. a person with the medical history of clinically significant new diseases within 30
             days from the time of visit for screening according to investigator's decision

          9. a person with hypersensitivity reaction to a drug or gelatin, or the medical history
             of clinically significant hypersensitivity reaction

         10. a person with the history of drug abuse, or with a positive reaction to a drug
             possible to be abused on urine drug screening

         11. a person with the medical history of alcohol abuse within two years from the time of
             visit for screening

         12. a person who is a smoker, or with a positive reaction on a urine nicotine test
             conducted at the time of visit for screening

         13. a person who donated whole blood within 60 days or constituents of blood within 30
             days, or received a blood transfusion within 30 days from the time of visit for
             screening

         14. a person taking other clinical trial drugs within 90 days from the time of visit for
             screening

         15. a person taking a prescription drug within 30 days, or a contraindicated drug or
             oriental medicine within 14 days from the time of visit for screening

         16. a person with a positive reaction to a serum test(hepatitis B test, hepatitis C test,
             HIV test, syphilis test)

         17. a person with hepatic enzymes(AST, ALT) more than 2.5 times of the reference upper
             limit(UNL) or total bilirubin more than 1.5 times of the reference upper limit(UNL) or
             creatinine more than 1.25 times of the reference upper limit(UNL)

         18. a person expected to be hard to complete a clinical trial due to physical or mental
             status according to investigator's medical decision at the time of visit for screening

         19. a person decided to be inappropriate to participate in this clinical trial according
             to investigator's medical decision on the result of laboratory tests, such as complete
             blood cell count, general chemical test, clinicochemical urinalysis, and physical
             examination, vital signs, ECG, other tests excluding exclusion criteria 17 items
             conducted before subject selection for a clinical trial