araag2/HINT huggingface dataset:
Clinical trial NCT02043678 (phase 3, status: active, not recruiting)
Conditions: prostatic neoplasms
ICD codes: B38.81, N42.31, Z87.430, N40.0, N40.1
Drugs: radium-223 dichloride (xofigo, bay88-8223), matching placebo (normal saline), abiraterone, prednisone/prednisolone
SMILES: Cl[223Ra]Cl, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, [H][C@@]12CC=C(C3=CC=CN=C3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C, [H][C@@]12CC[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)C=C[C@]12C
Eligibility criteria:

        Inclusion Criteria:

          -  Histologically confirmed adenocarcinoma of the prostate

          -  Male subjects of age ≥ 18 years

          -  Prostate cancer progression documented by prostate specific antigen (PSA) according to
             the Prostate Cancer Working Group 2 (PCWG2) criteria or radiological progression
             according to Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1

          -  Two or more bone metastases on bone scan within 4 weeks prior to randomization with no
             lung, liver, other visceral and/or brain metastasis

          -  Asymptomatic or mildly symptomatic prostate cancer

          -  Subjects who received combined androgen blockade with an anti-androgen must have shown
             PSA progression after discontinuing the anti-androgen prior to enrollment

          -  Maintenance of medical castration or surgical castration with testosterone less than
             50 ng/dL (1.7nmol/L)

          -  Eastern Cooperative Oncology Group performance status (ECOG PS) score 0 or 1

        Exclusion Criteria:

          -  Prior cytotoxic chemotherapy for the treatment of CRPC, including taxanes,
             mitoxantrone and estramustine

          -  Any chronic medical condition requiring a higher dose of corticosteroid than 5 mg
             prednisone/prednisolone twice daily

          -  Pathological finding consistent with small cell carcinoma of the prostate

          -  History of visceral metastasis, or presence of visceral metastasis detected by
             screening imaging examinations

          -  History of or known brain metastasis

          -  Malignant lymphadenopathy exceeding 3 cm in short-axis diameter

          -  Blood transfusion or erythropoietin stimulating agents prior 4 weeks of screening and
             during the whole screening period before randomization

          -  Imminent spinal cord compression based on clinical findings and/or magnetic resonance
             imaging (MRI). Subjects with history of spinal cord compression should have completely
             recovered

          -  Use of opiate analgesics for cancer-related pain, including codeine and
             dextropropoxyphene, currently or anytime during the 4- week period prior to
             randomization.
Clinical trial NCT02044354 (phase 3, status: unknown status)
Conditions: metastatic castration-resistant prostate cancer
ICD codes: C61, D29.1, D40.0, Z15.03, Z80.42, Z85.46, Z12.5
Drugs: taxotere, jevtana
SMILES: [H][N]([H])([H])[Pt](Cl)(Cl)[N]([H])([H])[H], [H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C4=CC=CC=C4)C(C)=C([C@@H](OC)C(=O)[C@]1(C)[C@H](C[C@H]1OC[C@@]21OC(C)=O)OC)C3(C)C
Eligibility criteria:

        Inclusion Criteria:

          -  Affiliated to a social security regimen ;

          -  Male patients older than 18 years ;

          -  Histologically confirmed adenocarcinoma of the prostate ;

          -  Continued androgen deprivation therapy either by LHRH agonists/antagonists or
             orchidectomy ;

          -  Serum testosterone <0.50 ng/ml (1.7 nmol/L) ;

          -  Progressive disease (PSA progression or radiological progression or clinical
             progression) ;

          -  ECOG 0-2 ;

          -  Information delivered to patient and informed consent form signed by the patient or
             his legal representative ;

          -  Adequate organ or bone marrow function as evidenced by:

               -  Hemoglobin >/= 10 g/dL

               -  Absolute neutrophil count >/=1.5 x 109/L,

               -  Platelet count >/=100 x 109/L,

               -  AST/SGOT and/or ALT/SGPT </=1.5 x ULN;

               -  Total bilirubin </=1.5 x ULN,

               -  Serum creatinine </=1.5 x ULN. If creatinine 1.0 - 1.5 xULN, creatinine clearance
                  will be calculated according to CKD-EPI formula and patients with creatinine
                  clearance <60 mL/min should be excluded

        Exclusion Criteria:

          -  Patients having received an investigational drug and/or prior surgery, radiation,
             chemotherapy, or other anti-cancer therapy within 4 weeks prior enrolment in the
             study, excepted radiotherapy directed to a single bone lesions which is nonacceptable
             if within 2 weeks ;

          -  Prior treatment with Taxotere or Jevtana ;

          -  Pre-existing symptomatic peripheral neuropathy grade > 2 (CTCAE V4) ;

          -  Uncontrolled cardiac arrhythmias, angina pectoris, and/or hypertension. History of
             congestive heart failure (NYHA III or IV) or myocardial infarction within last 6
             months is also not allowed ;

          -  History of severe hypersensitivity reaction (grade ≥3) to polysorbate 80 containing
             drugs ;

          -  Uncontrolled severe illness or medical condition (including uncontrolled diabetes
             mellitus), active infection including HIV infection, active Hepatitis B or C infection
             that would preclude participation in the trial ;

          -  Concurrent or planned treatment with strong inhibitors or strong inducers of
             cytochrome P450 3A4/5 (a one week wash-out period is necessary for patients who are
             already on these treatments) ;
Clinical trial NCT02045290 (phase 3, status: completed)
Conditions: type 1 diabetes
ICD codes: E10.65, E10.9, E10.21, E10.36, E10.41, E10.42, E10.44
Drugs: metformin, placebo
SMILES: CSCC[C@H](N)C(O)=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

        1. Meets eligibility criteria of the main study, Metformin Therapy for Overweight
        Adolescents With Type 1 Diabetes (NCT01881828).

        Exclusion Criteria:

        1. Low hemoglobin or hematocrit as defined by each local institution's rules for insulin
        clamps or if no institutional requirements a Hematocrit <30% or hemoglobin <10 gm/dL
Clinical trial NCT02046564 (phase 3, status: completed)
Conditions: major depressive disorder
ICD codes: F33.0, F33.1, F33.9, F32.0, F32.1, F32.9, F33.40
Drugs: asc-01, placebo
SMILES: CN[C@H]1CC[C@@H](C2=CC(Cl)=C(Cl)C=C2)C2=CC=CC=C12, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Patients who are either inpatients or outpatients.

          -  Patients who are able to understand necessary information for giving consent to
             undergo examinations, observations, and evaluations specified in this clinical
             protocol, and who are able to give written consent based on a full understanding of
             the trial.

          -  Patients who have been given a diagnosis of "Major Depressive Disorder, Single
             Episode" or "Major Depressive Disorder, Recurrent" according to the DSM-5 and who have
             a current episode of major depression that has been continuing for at least 8 weeks

          -  Patients with a HAM-D 17 total score of 18 or more at the Screening Period evaluation

        Exclusion Criteria:

          -  Female patients of childbearing potential who wish to become pregnant during the trial
             period or within 4 weeks after completion or discontinuation of the trial

          -  Pregnant or breast-feeding female patients, or female patients who may be pregnant

          -  Patients judged to be intolerant to all antidepressant (including drugs not used for
             their current episodes of major depression) based on their treatment history

          -  Patients who have had electroconvulsive therapy

          -  Patients who have enrolled in a clinical trial of other drugs or medical devices
             within 1 month before the time of informed consent

          -  Patients who have a medical history suggesting a risk of developing serious adverse
             events or symptoms that may hinder efficacy/safety evaluation (eg, symptoms of
             fibromyalgia, or premenstrual syndrome etc that overlap with depressive symptoms)

          -  Patients with complications or a history of diabetes mellitus, or patients who have
             been judged to be diabetic

               -  fasting blood glucose level ≥ 126 mg/dL

               -  2-hour glucose level in 75-g oral glucose tolerance test (OGTT) ≥ 200 mg/dL

               -  non-fasting blood glucose level ≥ 200 mg/dL

               -  HbA1c [NGSP level] ≥ 6.5%

          -  Patients who are undergoing treatment for thyroid disease (except for patients whose
             disease has been stabilized with drug therapy for 3 months or longer before the time
             of informed consent)

          -  Patients who have a history of neuroleptic malignant syndrome or serotonin syndrome

          -  Patients who have a history of seizure disorder (eg, epilepsy)
Clinical trial NCT02054702 (phase 3, status: completed)
Conditions: schizophrenia
ICD codes: F20.0, F20.1, F20.2, F20.3, F20.5, F20.89, F20.9
Drugs: brexpiprazole, aripiprazole
SMILES: O=C1NC2=CC(OCCCCN3CCN(CC3)C3=C4C=CSC4=CC=C3)=CC=C2C=C1, ClC1=CC=CC(N2CCN(CCCCOC3=CC4=C(CCC(=O)N4)C=C3)CC2)=C1Cl
Eligibility criteria:

        Inclusion Criteria:

          -  18 to 65 years of age, inclusive, at the time of informed consent with a diagnosis of
             schizophrenia as defined by the Diagnostic and Statistical Manual of Mental Disorders,
             Fourth Edition, Text Revision (DSM-IV-TR) and confirmed by the Mini International
             Neuropsychiatric Interview (M.I.N.I) for Schizophrenia and Psychotic Disorders Studies

          -  Would benefit from hospitalization or continued hospitalization for treatment of a
             current acute relapse of schizophrenia at trial entry

          -  Are experiencing an acute exacerbation of psychotic symptoms and marked deterioration
             of usual function as demonstrated by all of the following:

          -  Positive and Negative Syndrome Scale (PANSS) Total Score of ≥ 80

          -  Score of ≥ 4 on two or more of the following PANSS items at screening: hallucinatory
             behavior, unusual thought content, conceptual disorganization, or suspiciousness

          -  Clinical Global Impression - Severity of Illness Scale (CGI-S) score ≥ 4 (moderately
             ill)

        Exclusion Criteria:

          -  Are presenting with a first episode of schizophrenia based on the clinical judgment of
             the investigator

          -  Have been hospitalized > 21 days for the current acute episode at the time of the
             baseline visit

          -  Have a current DSM-IV-TR Axis I diagnosis other than schizophrenia, including, but not
             limited to, schizoaffective disorder, major depressive disorder (MDD), bipolar
             disorder, post-traumatic stress disorder, anxiety disorders, delirium, dementia,
             amnestic, or other cognitive disorders; also borderline, paranoid, histrionic,
             schizotypal, schizoid, antisocial personality disorders or mental retardation.

          -  Improvement of ≥ 20% in total PANSS score between the screening and baseline
             assessments.
Clinical trial NCT02054897 (phase 3, status: completed)
Conditions: diabetes, diabetes mellitus, type 2
ICD codes: E23.2, N25.1, P70.2, O24.92, Z83.3, Z86.32, E10.65, E11.65, E11.9, E11.21, E11.36, E11.41, E11.42, E11.44
Drugs: semaglutide, placebo
SMILES: CC[C@H](C)[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)CC1=CNC=N1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria: - For Japan only: Male or female, age above or equal to 20 years at the
        time of signing inform consent - Subjects diagnosed with type 2 diabetes and treated with
        diet and exercise for at least 30 days before screening - HbA1c 7.0 - 10.0 % (53 - 86
        mmol/mol) (both inclusive) Exclusion Criteria: - Female who is pregnant, breast-feeding or
        intends to become pregnant or is of child-bearing potential and not using adequate
        contraceptive method (adequate contraceptive measures as required by local regulation or
        practice) throughout the trial including the 5 week follow-up period. United Kingdom:
        Adequate contraceptive measures are defined as established use of oral, injected or
        implanted hormonal methods of contraception, placement of an intrauterine device or
        intrauterine system, barrier methods of contraception (condom or occlusive cap with
        spermicidal foam/gel/film/cream/suppository), male sterilisation (where partner is sole
        partner of subject), or true abstinence (when in line with preferred and usual lifestyle) -
        Any chronic disorder or severe disease which, in the opinion of the investigator, might
        jeopardise subject's safety or compliance with the protocol - Treatment with any glucose
        lowering agent(s) in a period of 90 days prior to screening. An exception is short-term
        treatment (no longer than 7 days in total) with insulin in connection with inter-current
        illness - History of chronic or idiopathic acute pancreatitis - Screening calcitonin value
        above or equal to 50 ng/L (pg/mL) - Personal or family history of medullary thyroid
        carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN 2) - Impaired renal function
        defined as eGFR (estimated glomerular filtration rate ) below 30 mL/min/1.73 m^2 per
        modification of diet in renal disease (MDRD) formula (4 variable version) - Acute coronary
        or cerebrovascular event within 90 days before randomisation - Heart failure, New York
        Heart Association class IV
Clinical trial NCT02064439 (phase 3, status: completed)
Conditions: pulmonary embolism, thromboembolism, thrombosis, venous thrombosis, venous thromboembolism
ICD codes: I27.82, Z86.711, I26.01, I26.09, I26.90, I26.99, I26.93, O88.22, O88.23, O88.211, O88.212, O88.213, O88.219, I81, K64.5, I51.3, I67.6, I74.11, I74.5, I74.8, K64.5, I67.6, O87.3, O22.50, O22.51, O22.52, O22.53, O88.22, O88.23, O88.211, O88.212, O88.213, O88.219
Drugs: bay 59-7939, bay 59-7939, asa
SMILES: ClC1=CC=C(S1)C(=O)NC[C@H]1CN(C(=O)O1)C1=CC=C(C=C1)N1CCOCC1=O, ClC1=CC=C(S1)C(=O)NC[C@H]1CN(C(=O)O1)C1=CC=C(C=C1)N1CCOCC1=O, CC(=O)OC1=CC=CC=C1C(O)=O
Eligibility criteria:

        Inclusion Criteria:

          -  Patients with confirmed symptomatic PE and/or DVT who have been treated for 6 to 12
             months and did not interrupt anticoagulation for longer than 1 week

        Exclusion Criteria:

          -  Legal lower age limitations (country specific) Indication for therapeutic-dosed
             anticoagulants Indication for antiplatelet therapy or a conventional non-steroid
             anti-inflammatory drug (NSAID) Hepatic disease which is associated with coagulopathy
             leading to a clinically relevant bleeding risk Calculated creatinine clearance < 30
             mL/min
Clinical trial NCT02065791 (phase 3, status: completed)
Conditions: diabetes mellitus, type 2, diabetic nephropathy
ICD codes: E11.65, E11.9, E11.21, E11.36, E11.41, E11.42, E11.44, E10.21, E11.21, E13.21, E08.21, E09.21
Drugs: canagliflozin, placebo
SMILES: [H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C1=CC=C(C)C(CC2=CC=C(S2)C2=CC=C(F)C=C2)=C1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Type 2 diabetes mellitus with a hemoglobin A1c (HbA1c) greater than or equal to (>=)
             6.5 percent (%) and less than or equal to (<=) 12.0%, with an estimated glomerular
             filtration rate (eGFR) of >= 30 milliliter (mL)/minute (min)/1.73meter (m)^2 and less
             than (<) 90 mL/min/1.73 m^2

          -  Participants need to be on a stable maximum tolerated labeled daily dose of an
             angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB)
             for at least 4 weeks prior to randomization

          -  Must have a urine albumin to creatinine ratio (UACR) of greater than (>) 300 milligram
             (mg)/gram (g) and <= 5000 mg/g

        Exclusion Criteria:

          -  History of diabetic ketoacidosis or type 1 diabetes mellitus

          -  History of hereditary glucose-galactose malabsorption or primary renal glucosuria

          -  Renal disease that required treatment with immunosuppressive therapy

          -  Known significant liver disease

          -  Current or history of New York Heart Association (NYHA) Class IV heart failure

          -  Blood potassium level >5.5 millimole (mmol)/liter (L) during Screening
Clinical trial NCT02066298 (phase 3, status: completed)
Conditions: asthma
ICD codes: J45.998, J82.83, J45.909, J45.991, J45.20, J45.30, J45.40
Drugs: mometasone 220mcg bid, tiotropium respimat 5mcg qd, placebo
SMILES: [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C, [H][C@]12O[C@@]1([H])[C@]1([H])C[C@@]([H])(C[C@@]2([H])[N+]1(C)C)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Physician-diagnosed asthma for at least previous 12 months.

          -  Able to perform reproducible spirometry.

          -  Baseline FEV1≥70% of predicted.

          -  Asthma confirmed either by:

               -  Beta-agonist reversibility to 4 puffs albuterol ≥ 12% OR

               -  Methacholine PC20 ≤ 16 mg/ml

          -  At least 1 of the following indications for chronic controller therapy:

               -  Asthma Symptoms > 2 days/week OR

               -  Nocturnal Asthma Symptoms > 2 nights/month OR

               -  Short-acting beta-agonist use for symptom control > 2 days/week

          -  For participants ≥18 years of age: Ability to provide informed consent. For
             participants under 18 years of age: Ability to provide verbal or written assent and
             ability of parent to provide informed consent.

          -  Willingness, if female and able to conceive, to utilize one medically-acceptable form
             of contraception.

        Exclusion Criteria:

          -  Chronic inhaled or oral corticosteroid therapy.

          -  Use of inhaled or oral corticosteroid therapy within 6 weeks.

          -  New allergen immunotherapy within the past 3 months or anticipated changes to an
             ongoing immunotherapy regimen.

          -  Use of omalizumab within 3 months.

          -  History of:

               -  bladder-neck obstruction, urinary retention or benign prostatic hyperplasia

               -  narrow angle glaucoma

               -  significant cardiovascular disorders and arrhythmias

               -  life-threatening asthma requiring treatment with intubation or mechanical
                  ventilation within the past 5 years

          -  Respiratory tract infection within past 6 weeks.

          -  History of smoking within the past 1 year, or > 10 pack-years total if ≥ 18 years of
             age, or > 5 pack-years total if < 18 years of age.

          -  Chronic diseases or medical conditions (other than asthma) that could put the
             participant at risk by participation, e.g. chronic diseases of the lung (other than
             asthma), heart, liver, kidney, endocrine or nervous system, or immunodeficiency.
Clinical trial NCT02070757 (phase 3, status: completed)
Conditions: healthcare-associated pneumonia, ventilator-associated pneumonia, lung diseases
ICD codes: J95.851, J84.115, M05.10, M05.111, M05.112, M05.119, M05.121, M05.122
Drugs: ceftolozane/tazobactam, meropenem
SMILES: CN1C(N)=C(NC(=O)NCCN)C=[N+]1CC1=C(N2[C@H](SC1)[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=NSC(N)=N1)C2=O)C([O-])=O, CN(C)CCOC(C)(C1=CC=CC=C1)C1=CC=CC=N1
Eligibility criteria:

        Key Inclusion Criteria:

          -  Adult participants diagnosed with either VABP or ventilated HABP requiring IV
             antibiotic therapy;

          -  Intubated and on mechanical ventilation at the time of randomization;

          -  New or progressive infiltrate on chest radiography consistent with pneumonia;

          -  Presence of clinical criteria consistent with a diagnosis of ventilated nosocomial
             pneumonia.

        Key Exclusion Criteria:

          -  History of moderate or severe hypersensitivity reactions to beta-lactam antibiotics;

          -  Prior non-study antibiotics for > 24 hours;

          -  Gram stain of lower respiratory tract specimen showing only gram positive bacteria;

          -  Active immunosuppression;

          -  End-stage renal disease or requirement for dialysis;

          -  Expected survival < 72 hours;

          -  Severe confounding respiratory condition (i.e., chest trauma with paradoxical
             respiration);

          -  Known or suspected community-acquired bacterial pneumonia.

          -  Anticipated concomitant use of any of the following medications during the course of
             study therapy: valproic acid or divalproex sodium. Anticipated concomitant use of
             serotonin re-uptake inhibitors, tricyclic antidepressants, or serotonin 5-HT1 receptor
             agonists (triptans), meperidine, or buspirone during the course of linezolid
             treatment.

          -  Receipt of a monoamine oxidase inhibitor within 14 days prior to the first dose of
             study drug or anticipated concomitant use during the course of linezolid therapy.