araag2/HINT huggingface dataset:
Clinical trial NCT02203838 (phase 3, status: completed)
Conditions: schizophrenia
ICD codes: F20.0, F20.1, F20.2, F20.3, F20.5, F20.89, F20.9
Drugs: rbp-7000
SMILES: CC1=C(CCN2CCC(CC2)C2=NOC3=C2C=CC(F)=C3)C(=O)N2CCCCC2=N1
Eligibility criteria:

        Inclusion Criteria:

        "De Novo" Patients

          -  Diagnosis of schizophrenia as defined by Diagnostic and Statistical Manual, Edition 4,
             text revision (DSM-IV-TR) criteria

          -  Total PANSS score <=70 at the time of screening (Visit 1)

          -  Otherwise healthy on the basis of physical examinatIon

          -  Provided written informed consent

        "Roll-over Patients

          -  Provided written consent to participate in this study

          -  Be considered eligible to enroll based on End of Study (EOS) (Day 57 of Study
             RB-US-09-0010) assessments and the medical judgment of the investigator

        Exclusion Criteria:

        "De Novo" Patients

          -  Patients taking daily oral risperidone at a dose plus/minus 6 mg/day

          -  Patients taking any risperidone or 9-hydroxyrisperidone long-acting injectable
             formulation within 120 days of study screening (Visit 1)

          -  Patients who have received a long-acting injectable antipsychotic within 120 days of
             screening (Visit 1)

          -  Patients with evidence or history (in the past six months prior to screening) of a
             significant hepatic disorder that may either compromise patient safety or interfere
             with the safety and/or outcome evaluation of the study drug, including:

               -  Acute or chronic hepatitis, including but not limited to hepatitis B or C

               -  Total bilirubin greater than 1.5 times the upper limit of normal (ULN), or

               -  Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) greater than 2
                  times ULN

          -  Patients with a history of drug-induced leukopenia

          -  Patients with other medical conditions including, but not limited to, history of heart
             attack (myocardial infarction) or brain injury (traumatic injury with loss of
             consciousness and/or cerebrovascular accident), and clinically significant low blood
             pressure or arrhythmias as interpreted by the primary investigator (PI) or medically
             qualified sub-investigator

          -  Patients with epilepsy or other seizure disorders, Parkinson's disease or dementia

        "Roll-over" Patients

          -  Patients requiring an inpatient treatment setting at the end of Study RB-US-09-0010

          -  Patients with an unstable medical condition developed during Study RB-US-09-0010

          -  Women of childbearing potential who have a positive pregnancy test at screening (Visit
             1), who are pregnant or breastfeeding, seeking pregnancy, or failing to use adequate
             contraceptive methods during the study
Clinical trial NCT02207088 (phase 3, status: completed)
Conditions: chronic hepatitis c, hepatitis c virus, compensated cirrhosis, severe renal impairment, end-stage renal disease
ICD codes: B18.2, B18.0, B18.1, B18.8, B18.9, K71.3, K71.4, B00.81, B25.1, B26.81, B58.1, K75.4, A51.45, B17.2, K74.3, K74.4, K74.5, K74.60, K74.69, P78.81, K70.30, N18.6, I12.0, I13.11, I13.2
Drugs: ombitasvir/paritaprevir/ritonavir, dasabuvir, ribavirin
SMILES: [H][C@@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](CN1C(=O)[C@H](CCCCC\C=C/2)NC(=O)C1=CN=C(C)C=N1)OC1=NC2=C(C=CC=C2)C2=C1C=CC=C2)C(=O)NS(=O)(=O)C1CC1, CC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1, NC(=O)C1=NN(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Eligibility criteria:

        Inclusion Criteria:

          1. Positive for anti-HCV Ab (Antibody) and HCV RNA >1,000 IU/mL at Screening.

          2. Screening laboratory result indicating HCV genotype 1 infection.

          3. Subject has never received antiviral treatment for hepatitis C infection
             (treatment-naive subject) or subject has received previous treatment with
             peginterferon with or without RBV with non-response (HCV RNA quantifiable at end of
             treatment or relapsed after end of treatment).

          4. Estimated Glomerular Filtration Rate (eGFR) < 30 mL/min/1.73 m^2 as estimated by the
             Modification of Diet in Renal Disease (MDRD) method.

        Exclusion Criteria:

          1. Women who are pregnant or breastfeeding.

          2. Positive test result for Hepatitis B surface antigen (HBsAg) or anti-Human
             Immunodeficiency Virus (HIV Ab).

          3. Any current or past clinical evidence of Child-Pugh B or C classification or clinical
             history of liver decompensation such as ascites (noted on physical exam), variceal
             bleeding, or hepatic encephalopathy.
Clinical trial NCT02207231 (phase 3, status: completed)
Conditions: psoriasis
ICD codes: L40.0, L40.4, L40.8, L40.9, L40.1, L40.50
Drugs: guselkumab 100 mg, placebo for guselkumab, adalimumab, placebo for adalimumab
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Have a diagnosis of plaque-type psoriasis (with or without psoriatic arthritis) at
             least 6 months before the first administration of study agent

          -  Have a Psoriasis Area and Severity Index (PASI) greater than or equal to (>=) 12 at
             Screening and at Baseline

          -  Have an Investigator's Global Assessment (IGA) score >=3 at Screening and at Baseline

          -  Have an involved body surface area (BSA) >=10 percent (%) at Screening and at Baseline

          -  Must be a candidate for either systemic therapy or phototherapy for psoriasis

        Exclusion Criteria:

          -  Participants with nonplaque forms of psoriasis (for example, erythrodermic, guttate,
             or pustular) or with current drug-induced psoriasis (for example, a new onset of
             psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel
             blockers, or lithium)

          -  Participants who have ever received guselkumab or adalimumab

          -  History or current signs or symptoms of severe, progressive, or uncontrolled renal,
             hepatic, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic,
             hematologic, rheumatologic, psychiatric, or metabolic disturbances

          -  Has any condition that, in the opinion of the investigator, would make participation
             not be in the best interest (for example, compromise the well-being) of the
             participant or that could prevent, limit, or confound the protocol-specified
             assessments

          -  Is pregnant, nursing, or planning a pregnancy (both men and women) within 5 months
             following the last administration of study drug
Clinical trial NCT02207244 (phase 3, status: completed)
Conditions: psoriasis
ICD codes: L40.0, L40.4, L40.8, L40.9, L40.1, L40.50
Drugs: guselkumab 100 mg, placebo for guselkumab, adalimumab, placebo for adalimumab
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Have a diagnosis of plaque-type psoriasis (with or without psoriatic arthritis) at
             least 6 months before the first administration of study agent

          -  Have a Psoriasis Area and Severity Index (PASI) greater than or equal to (>=) 12 at
             Screening and at Baseline

          -  Have an Investigator's Global Assessment (IGA) score >=3 at Screening and at Baseline

          -  Have an involved body surface area (BSA) >=10 percent (%) at Screening and at Baseline

          -  Must be a candidate for either systemic therapy or phototherapy for psoriasis

        Exclusion Criteria:

          -  Participants with nonplaque forms of psoriasis (for example, erythrodermic, guttate,
             or pustular) or with current drug-induced psoriasis (for example, a new onset of
             psoriasis or an exacerbation of psoriasis from beta blockers, calcium channel
             blockers, or lithium)

          -  Participants who have ever received guselkumab or adalimumab

          -  History or current signs or symptoms of severe, progressive, or uncontrolled renal,
             hepatic, cardiac, vascular, pulmonary, gastrointestinal, endocrine, neurologic,
             hematologic, rheumatologic, psychiatric, or metabolic disturbances

          -  Has any condition that, in the opinion of the investigator, would make participation
             not be in the best interest (for example, compromise the well-being) of the
             participant or that could prevent, limit, or confound the protocol-specified
             assessments

          -  Is pregnant, nursing, or planning a pregnancy (both men and women) within 5 months
             following the last administration of study drug
Clinical trial NCT02217267 (phase 3, status: completed)
Conditions: peripheral neuropathy
ICD codes: G90.09
Drugs: lidocaine, placebo
SMILES: OC1=CC(Cl)=CC=C1OC1=C(Cl)C=C(Cl)C=C1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Peripheral neuropathic pain from peripheral nerve injury within 6 months after injury

          -  Well understand to Thai language in writing or listening

        Exclusion Criteria:

          -  Underlying Heart disease or Arrhythmia

          -  Allergy to lidocaine, Gabapentin, Carbamazepine, tramadol

          -  History of epilepsy

          -  History of lidocaine used

          -  Underlying Psychiatric disease

          -  History of drug abuse

          -  Pregnancy and nursing
Clinical trial NCT02218008 (phase 3, status: completed)
Conditions: major depressive disorder
ICD codes: F33.0, F33.1, F33.9, F32.0, F32.1, F32.9, F33.40
Drugs: alks 5461, placebo
SMILES: CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]1CC4=C5C(O[C@@H]2[C@@]35CCN1CC1CC1)=C(O)C=C4, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Have a BMI of 18.0 to 40.0 kg/m2, inclusive

          -  Agree to use an acceptable method of contraception for the duration of the study

          -  Have an MDD primary diagnosis

          -  Have no more than 2 inadequate responses to antidepressant therapy (ADT) in the
             current Major Depressive Episode (MDE)

          -  Additional criteria may apply

        Exclusion Criteria:

          -  Have a current primary Axis-I disorder other than MDD

          -  Have used opioid agonists (eg, codeine, oxycodone, tramadol, morphine) or opioid
             antagonists (eg, naloxone, naltrexone) within 14 days

          -  Have received electroconvulsive therapy treatment within the last 2 years or received
             more than one course of electroconvulsive treatment during their lifetime

          -  Have attempted suicide within the past 2 years

          -  Have a positive test for drugs of abuse

          -  Are pregnant, planning to become pregnant, or breastfeeding

          -  Have a history of intolerance, allergy, or hypersensitivity to buprenorphine or opioid
             antagonists (eg, naltrexone, naloxone)

          -  Have had a significant blood loss or blood donation within 60 days

          -  Additional criteria may apply
Clinical trial NCT02219477 (phase 3, status: completed)
Conditions: chronic hepatitis c, decompensated cirrhosis, hepatitis c virus
ICD codes: B18.2, B18.0, B18.1, B18.8, B18.9, K71.3, K71.4, B00.81, B25.1, B26.81, B58.1, K75.4, A51.45, B17.2
Drugs: ombitasvir/paritaprevir/ritonavir, dasabuvir, ribavirin
SMILES: [H][C@@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](CN1C(=O)[C@H](CCCCC\C=C/2)NC(=O)C1=CN=C(C)C=N1)OC1=NC2=C(C=CC=C2)C2=C1C=CC=C2)C(=O)NS(=O)(=O)C1CC1, CC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1, NC(=O)C1=NN(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Eligibility criteria:

        Inclusion Criteria:

          1. HCV GT1- or GT4-infection defined as: positive for anti-HCV Ab, HCV RNA > 1,000 IU/mL
             and laboratory result indicating HCV GT1 or GT4 infection at Screening.

          2. Evidence of cirrhosis by prior liver biopsy, FibroScan or by radiograph (i.e.,
             computed tomography [CT] scan or magnetic resonance imaging [MRI]).

          3. Child-Pugh Score of 7 - 9, inclusive, at time of Screening.

        Exclusion Criteria:

          1. Women who are pregnant or breastfeeding.

          2. Positive test result for Hepatitis B surface antigen (HbsAg) or anti-HIV antibodies
             (HIV Ab).

          3. Prior or current use of any other investigational or commercially available anti-HCV
             agents other than interferon/RBV and/or pegylated interferon (pegIFN)/RBV (including
             but not limited to telaprevir, boceprevir, sofosbuvir and simeprevir).

          4. Confirmed presence of hepatocellular carcinoma indicated on imaging techniques such as
             CT scan or MRI within 3 months prior to Screening or on an ultrasound performed at
             Screening (a positive ultrasound result will be confirmed with CT scan or MRI).

          5. Any current or past evidence of Child-Pugh C classification.
Clinical trial NCT02219503 (phase 3, status: completed)
Conditions: chronic hepatitis c infection, compensated cirrhosis
ICD codes: B00.81, B25.1, B26.81, B58.1, K75.4, A51.45, B17.2, K74.3, K74.4, K74.5, K74.60, K74.69, P78.81, K70.30
Drugs: ombitasvir/paritaprevir/ritonavir, dasabuvir
SMILES: [H][C@@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](CN1C(=O)[C@H](CCCCC\C=C/2)NC(=O)C1=CN=C(C)C=N1)OC1=NC2=C(C=CC=C2)C2=C1C=CC=C2)C(=O)NS(=O)(=O)C1CC1, CC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1
Eligibility criteria:

        Inclusion Criteria:

          1. Chronic HCV genotype 1-infection prior to study enrollment. Chronic HCV-infection is
             defined as the following:

               -  Positive for anti-HCV antibody (Ab) or HCV RNA > 1,000 IU/mL at least 6 months
                  before Screening, and positive for HCV RNA and anti-HCV Ab at the time of
                  Screening; or

               -  HCV RNA > 1,000 IU/mL at the time of Screening with a liver biopsy consistent
                  with chronic HCV-infection (or a liver biopsy performed prior to enrollment with
                  evidence of chronic hepatitis C disease).

          2. Screening laboratory result indicating HCV genotype 1b-infection.

          3. Compensated cirrhosis defined as a Child-Pugh Score of 5 or 6 at Screening.

        Exclusion Criteria:

          1. Women who are pregnant or breastfeeding.

          2. Positive test result for Hepatitis B surface antigen (HBsAg) or positive human
             immunodeficiency virus (HIV) antibody (confirmed by Western Blot).

          3. Any current or past clinical evidence of Child-Pugh B or C classification or clinical
             history of liver decompensation such as ascites (noted on physical exam), variceal
             bleeding, or hepatic encephalopathy.

          4. Confirmed presence of hepatocellular carcinoma indicated on imaging techniques such as
             computed tomography (CT) scan or magnetic resonance imaging (MRI) within 3 months
             prior to Screening or on an ultrasound performed at Screening (a positive ultrasound
             result will be confirmed with CT scan or MRI.)

          5. Use of contraindicated medications within 2 weeks of dosing

          6. Screening laboratory analyses showing any of the following abnormal laboratory
             results:

               -  Calculated creatinine clearance (using Cockcroft-Gault method) < 30 mL/min

               -  Albumin < 2.8 g/dL

               -  International normalized ratio (INR) > 1.8. Participants with a known inherited
                  blood disorder and INR > 1.8 may be enrolled with permission of the AbbVie Study
                  Designated Physician.

               -  Hemoglobin < 10 g/dL

               -  Platelets < 25,000 cells per mm3

               -  Total bilirubin > 3.0 mg/dL
Clinical trial NCT02219932 (phase 3, status: completed)
Conditions: multiple sclerosis
ICD codes: G35, C81.18
Drugs: fampridine, placebo
SMILES: NC1=CC=NC=C1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Key Inclusion Criteria:

          -  Must have a diagnosis of primary-progressive, secondary-progressive,
             progressive-relapsing, or relapsing-remitting MS per revised McDonald Committee
             criteria [McDonald 2001; Polman 2005] as defined by Lublin and Reingold [Lublin and
             Reingold 1996] of at least 3 months duration

          -  Must have an Expanded Disability Status Scale (EDSS) score of 4 to 7, inclusive

          -  Must have walking impairment, as deemed by the Investigator

        Key Exclusion Criteria:

          -  History of human immunodeficiency virus (HIV)

          -  Presence of acute or chronic hepatitis. Subjects who have evidence of prior hepatitis
             infection that has been serologically confirmed as resolved are not excluded from
             study participation

          -  Known allergy to fampridine, pyridine-containing substances, or any of the inactive
             ingredients in the prolonged-release fampridine tablet

          -  Creatinine clearance (CrCl) of <80 mL/min

          -  History of malignant disease

          -  Presence of pulmonary disease

          -  A body mass index (BMI) ≥40 (BMI formula: BMI = mass [kg]/[height(m)]2)

        NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Clinical trial NCT02220907 (phase 3, status: completed)
Conditions: type 2 diabetes mellitus
ICD codes: E11.65, E11.9, E11.21, E11.36, E11.41, E11.42, E11.44
Drugs: teneligliptin/canagliflozin
SMILES: [H][C@]1(O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C1=CC=C(C)C(CC2=CC=C(S2)C2=CC=C(F)C=C2)=C1
Eligibility criteria:

        Inclusion Criteria:

          -  Men or women age ≥20 years old

          -  HbA1c of ≥7.0% and <10.5%

          -  FPG of ≤ 270 mg/dL

          -  Patients who are under dietary management and taking therapeutic exercise for diabetes
             over 12 weeks before treatment period

        Exclusion Criteria:

          -  Patients with type I diabetes, diabetes mellitus resulting from pancreatic disorder,
             or secondary diabetes

          -  Patients with serious diabetic complications

          -  Patients with hereditary glucose-galactose malabsorption or primary renal glucosuria

          -  Patients with Class III/IV heart failure symptoms according to New York Heart
             Association (NYHA) functional classification

          -  Patients with severe hepatic disorder or severe renal disorder.
Clinical trial NCT02220998 (phase 3, status: completed)
Conditions: hepatitis c virus infection
ICD codes: B00.81, B25.1, B26.81, B58.1, K75.4, A51.45, B17.2
Drugs: sof/vel, sof, rbv
SMILES: [H][C@](N=C(O)OC)(C(C)C)C(=O)N1[C@@]([H])(C)CC[C@@]1([H])C1=NC2=C(N1)C1=CC3=C(C=C1C=C2)C1=C(CO3)C=C(C=C1)C1=CN=C(N1)[C@]1([H])C[C@]([H])(COC)CN1C(=O)[C@]([H])(N=C(O)OC)C1=CC=CC=C1, CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](N2C=CC(=O)NC2=O)[C@](C)(F)[C@@H]1O)OC1=CC=CC=C1, NC(=O)C1=NN(C=N1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
Eligibility criteria:

        Inclusion Criteria:

          -  Willing and able to provide written informed consent

          -  HCV RNA ≥ 10^4 IU/mL

          -  HCV genotype 2

          -  Chronic HCV infection (≥ 6 months)

          -  Females of childbearing potential must have a negative serum pregnancy test

          -  Males and females of childbearing potential who engage in heterosexual intercourse
             must agree to use protocol specified method(s) of contraception

          -  Must be of generally good health, with the exception of chronic HCV infection, as
             determined by the investigator.

        Exclusion Criteria:

          -  Current or prior history of clinically-significant illness (other than HCV that may
             interfere with treatment, assessment or compliance with the protocol;

          -  Screening electrocardiogram (ECG) with clinically significant abnormalities

          -  Laboratory results outside of acceptable ranges at Screening

          -  Pregnant or nursing female or male with pregnant female partner

          -  Chronic liver disease of a non-HCV etiology (e.g., hemochromatosis, Wilson's disease,
             alfa-1 antitrypsin deficiency, cholangitis)

          -  Infection with hepatitis B virus (HBV) or human immunodeficiency virus (HIV)
Clinical trial NCT02224157 (phase 3, status: completed)
Conditions: asthma
ICD codes: J45.998, J82.83, J45.909, J45.991, J45.20, J45.30, J45.40
Drugs: budesonide/formoterol 'as needed' + budesonide placebo bid, budesonode bid + terbutaline 'as needed'
SMILES: COC1=CC=C(CC(C)NCC(O)C2=CC(NC=O)=C(O)C=C2)C=C1, CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1
Eligibility criteria:

        Inclusion Criteria:

          1. Provision of informed consent prior to any study specific procedures. For patients
             under-age, signed informed consent from both the patient and the patient's
             parent/legal guardian is required

          2. Male or Female, ≥12 years of age

          3. Documented diagnosis of asthma for at least 6 months prior to Visit 1

          4. Patients who are in need of GINA step 2 treatment

          5. Patients treated with a short acting inhaled bronchodilator(s) only should have
             pre-bronchodilator FEV1 ≥ 60 % of predicted normal (PN) and post-bronchodilator FEV1 ≥
             80 % PN

          6. Patients treated with low stable dose of ICS or leukotriene antagonists in addition to
             short acting inhaled bronchodilator(s) should have pre-bronchodilator FEV1 ≥80 % PN

          7. Patients should have reversible airway obstruction

          8. To be randomized patients must have used Bricanyl Turbuhaler as needed on at least 3
             separate days during the last week of the run in period

        Exclusion Criteria:

          1. Patient has a history of life-threatening asthma including intubation and intensive
             care unit admission

          2. Patient has had an asthma worsening requiring change in treatment other than short
             acting inhaled bronchodilator(s) within 30 days prior to Visit 1 and from Visit 1
             until randomization

          3. Patient has required treatment with oral, rectal or parenteral GCS within 30 days
             and/or depot parenteral GCS within 12 weeks prior to Visit 1

          4. Current or previous smoker with a smoking history of ≥ 10 pack years

          5. Pregnancy, breast-feeding or planned pregnancy during the study