Clinical trial NCT02031744 (phase 3, status: completed)
Conditions: non-small cell lung cancer
ICD codes: C78.00, C78.01, C78.02, D14.30, D14.31, D14.32, C34.2
Drugs: erlotinib [tarceva], placebo, onartuzumab [metmab]
SMILES: COCCOC1=CC2=C(C=C1OCCOC)C(NC1=CC(=CC=C1)C#C)=NC=N2, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Male or female, 18 years or older.

          -  Patients with an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.

          -  Histologically confirmed incurable Stage IIIB/IV NSCLC tumor.

          -  Met-positive status and results of epidermal growth factor receptor (EGFR)-activating
             mutation testing.

          -  Available tumor tissue sample or agreement to take such a sample.

          -  Radiographic evidence of disease. Lesions must be outside a previous radiotherapy
             field if they are the sole site of disease, unless disease progression has occurred at
             that site since radiation.

          -  Prior treatment with at least one platinum-based line of treatment for locally
             advanced, unresectable/inoperable disease or metastatic disease, and no more than one
             additional line of chemotherapy treatment, defined as follows:

          -  Adjuvant/neoadjuvant chemotherapy or chemoradiation counts as a line of therapy if <
             12 months have elapsed between the last dose and the date of recurrence. Combined
             treatment with chemotherapy and radiation constitutes a single regimen; surgery is not
             considered a regimen.

          -  Cytotoxic maintenance therapy that differs from first-line therapy is considered an
             additional line of therapy. However, changes in treatment due to intolerance or
             excessive toxicity are not considered an additional regimen.

          -  The last dose of prior chemotherapy must have been given >/= 21 days prior to Day 1
             (>/= 14 days for vinorelbine or other vinca alkaloids or gemcitabine).

          -  Anti-cancer agents used for pleurodesis are not counted as a line of therapy.

          -  Prior radiation therapy is allowed provided the patient has recovered from any toxic
             effects and >/= 7 days have elapsed between the last session and randomization.

          -  Patients must use effective contraception throughout the trial and until 3 months
             after the last dose.

        Exclusion Criteria:

          -  More than 30 days expsoure to an EGFR inhibitor or a known EGFR-toxicity resulting in
             dose modifications.

          -  Prior exposure to agents targeting either the HGF or MET pathway, including but not
             limited to crizotinib, cabozantinib, ficlatuzumab, rilotumumab, and tivantinib.

          -  Pleural effusion, pericardial fluid, or ascites requiring drainage every other week or
             more frequently.

          -  Brain metastases or spinal cord compression that were not definitively treated with
             surgery and/or radiation or that were previously diagnosed and treated without
             evidence of clinically stable disease for >/= 14 days. Patients with treated central
             nervous system (CNS) metastases who are asymptomatic and on a stable dose of
             corticosteroid for >/= 14 days prior to randomization are eligible.

          -  History of another cancer in the previous 5 years, except for appropriately treated
             carcinoma in situ of the cervix, non-melanoma skin cancer, stage I uterine cancer, or
             other cancers that are curable.

          -  Life expectancy < 12 weeks.

          -  Radiographically visible interstitial lung disease (ILD) or a history of it. History
             of radiation pneumonitis in the radiation field (fibrosis) is permitted.

          -  Inadequate hematologic, biological, or organ function.

          -  Significant history of cardiac disease.

          -  Serious active infection at the time of randomization or other serious underlying
             medical conditions that would impair the ability of the patient to receive protocol
             treatment, including positive HIV or active hepatitis B or C infections, significant
             gastrointestinal abnormalities, uncontrolled diabetes.

          -  Any inflammatory changes to the surface of the eye.

          -  Inability to take oral medication, need for intravenous alimentation, prior surgical
             procedures affecting absorption, or active peptic ulcer disease.

          -  Pregnant or breast-feeding women.

          -  Any major surgery within 2 weeks prior to randomization.

          -  Inability to understand the language(s) in which the HRQOL questionnaires are
             available.