Clinical trial NCT02116660 (phase 2, status: terminated)
Conditions: hiv infections
ICD codes: Z21
Drugs: raltegravir (mk-0518), nevirapine, lamivudine, tenofovir, emtricitabine, lopinavir, ritonavir, atazanavir, darunavir
SMILES: CN1C(=O)C(O)=C(N=C1C(C)(C)NC(=O)C1=NN=C(C)O1)C(=O)NCC1=CC=C(F)C=C1, CC1=C2NC(=O)C3=C(N=CC=C3)N(C3CC3)C2=NC=C1, CC1=CN([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)C(=O)NC1=O, C[C@H](CN1C=NC2=C1N=CN=C2N)OCP(O)(O)=O, NC1=NC(=O)N(C=C1F)[C@@H]1CS[C@H](CO)O1, CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1, CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1, CC(C)[C@H](NC(=O)N(C)CC1=CSC(=N1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=CN=CS1)CC1=CC=CC=C1, [H][C@@]12CCO[C@]1([H])OC[C@@H]2OC(=O)N[C@@H](CC1=CC=CC=C1)[C@H](O)CN(CC(C)C)S(=O)(=O)C1=CC=C(N)C=C1
Reason stopped: 
    this study was terminated early due to poor recruitment.
  
Eligibility criteria:

        Inclusion Criteria:

          -  Male, or non-pregnant, non-breastfeeding female

          -  No previous history of virological failure

          -  No previous exposure to non-nucleoside reverse transcriptase inhibitors or integrase
             inhibitors

          -  No previous history of intolerance to lamivudine

          -  At least 2 documented plasma HIV-1 RNA <50 copies/mL and no HIV-1 >50 copies/mL in the
             12 months before screening

          -  Receiving the same protease inhibitor/ritonavir plus tenofovir/emtricitabine
             combination for at least the 6 months before screening

          -  Has no major International Antiviral Society (IAS)-USA mutations on genotype testing
             performed before starting antiretroviral treatment

          -  Sexually-active participants and their partners of child-bearing potential agree to
             use a medically acceptable method of contraception from 2 weeks before Day 1 and for
             at least 6 months after the last dose of study drug (postmenopausal women are not
             required to use contraception; sexually-active male participants with a female partner
             of child-bearing potential must provide written informed consent to information
             regarding any pregnancy)

        Exclusion Criteria:

          -  Positive for hepatitis B surface antigen (HBsAg+) or anticipated need for hepatitis C
             virus treatment

          -  Liver cirrhosis

          -  Has a history of diabetes mellitus, defined as initiation of antidiabetic treatment or
             verification of diabetes in a case report form

          -  Has any cancer, excluding stable Kaposi Sarcoma

          -  Allergy or sensitivity to the investigational product or excipients

          -  Female participant who is nursing

          -  Female participant who is pregnant or intends to become pregnant

          -  Has an active Acquired Immunodeficiency Syndrome (AIDS)-defining event except stable
             Kaposi Sarcoma or HIV Wasting Syndrome

          -  Received any investigational drug within 30 days before screening

          -  Participated in any other clinical trial within 30 days before signing informed
             consent for the current trial