araag2/HINT huggingface dataset:
Clinical trial NCT02614183 (phase 3, status: completed)
Conditions: migraine
ICD codes: G43.B1, G43.D1, G43.B0, G43.D0, G43.A1, G43.411, G43.419
Drugs: galcanezumab, placebo
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Have a diagnosis of episodic migraine as defined by International Headache Society
             (IHS) International Classification of Headache Disorders (ICHD)-3 beta guidelines (1.1
             or 1.2) (ICHD-3 2013), with a history of migraine headaches of at least 1 year prior
             to screening, migraine onset prior to age 50 and MONTHLY frequency of 4-14 Migraine
             Headache Days (MHD).

        Exclusion Criteria:

          -  Are currently enrolled in or have participated within the last 30 days or within 5
             half-lives (whichever is longer) in a clinical trial involving an investigational
             product.

          -  Current use or prior exposure to Galcanezumab or another CGRP antibody.

          -  Known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic
             proteins, or to Galcanezumab.

          -  History of persistent daily headache, cluster headache or migraine subtypes including
             hemiplegic (sporadic or familial) migraine, ophthalmoplegic migraine, and migraine
             with brainstem aura (basilar-type migraine) defined by IHS ICHD-3 beta.
Clinical trial NCT02614196 (phase 3, status: completed)
Conditions: migraine
ICD codes: G43.B1, G43.D1, G43.B0, G43.D0, G43.A1, G43.411, G43.419
Drugs: galcanezumab, placebo
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Have a diagnosis of migraine as defined by International Headache Society (IHS)
             International Classification of Headache Disorders (ICHD)-3 beta version (1.1 or 1.2)
             (ICHD-3 2013), with a history of migraine headaches of at least 1 year prior to
             screening, migraine onset prior to age 50 and MONTHLY frequency of 4-14 MHD.

        Exclusion Criteria:

          -  Are currently enrolled in or have participated within the last 30 days or within 5
             half-lives (whichever is longer) in a clinical trial involving an investigational
             product.

          -  Current use or prior exposure to galcanezumab or another Calcitonin Gene-Related
             Peptide (CGRP) antibody.

          -  Known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic
             proteins, or to galcanezumab.

          -  History of persistent daily headache, cluster headache or migraine subtypes including
             hemiplegic (sporadic or familial) migraine, ophthalmoplegic migraine, and migraine
             with brainstem aura (basilar-type migraine) defined by IHS ICHD-3 beta.
Clinical trial NCT02614261 (phase 3, status: active, not recruiting)
Conditions: chronic migraine
ICD codes: G43.711, G43.719, G43.701, G43.709
Drugs: galcanezumab, placebo
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Have a diagnosis of chronic migraine as defined by International Headache Society
             (IHS) International Classification of Headache Disorders (ICHD)-3 beta guidelines
             (1.3) (ICHD-3 2013), with a history of migraine headaches of at least 1 year prior to
             screening, and migraine onset prior to age 50.

        Exclusion Criteria:

          -  Are currently enrolled in or have participated within the last 30 days or within 5
             half-lives (whichever is longer) in a clinical trial involving an investigational
             product.

          -  Current use or prior exposure to galcanezumab or another calcitonin gene-related
             peptide (CGRP) antibody.

          -  Known hypersensitivity to multiple drugs, monoclonal antibodies or other therapeutic
             proteins, or to galcanezumab.

          -  History of persistent daily headache, cluster headache or migraine subtypes including
             hemiplegic (sporadic or familial) migraine, ophthalmoplegic migraine, and migraine
             with brainstem aura (basilar-type migraine) defined by IHS ICHD-3 beta.
Clinical trial NCT02617485 (phase 3, status: completed)
Conditions: diffuse large b-cell lymphoma
ICD codes: S33.110S, S33.111S, S33.120S, S33.121S, S33.130S, S33.131S, S33.140S
Drugs: rituximab, doxorubicin, vincristine, cyclophosphamide, prednisone
SMILES: ClCCN(CCCl)P1(=O)NCCCO1, COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C(=O)CO)C(O)=C1C2=O, CC[C@]1(O)C[C@@H]2CN(C1)CCC1=C(NC3=CC=CC=C13)[C@@](C2)(C(=O)OC)C1=C(OC)C=C2N(C=O)[C@@H]3[C@]4(CCN5CC=C[C@](CC)([C@@H]45)[C@@H](OC(C)=O)[C@]3(O)C(=O)OC)C2=C1, ClCCN(CCCl)P1(=O)NCCCO1, [H][C@@]12CC=C(C3=CC=CN=C3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C
Eligibility criteria:

        Inclusion Criteria:

          1. Patients with histological confirmed CD20 (cluster of differentiation 20) positive
             diffuse large B cell lymphoma (DLBCL)

          2. Patients that had been diagnosed according to the WHO classification;

          3. Performance status ≤ 2 on the ECOG (Eastern Cooperative Oncology Group) / WHO (world
             Health Organization) scale, performance status of 3 will be accepted if impairment is
             caused by DLBCL complications and improvement is expected once therapy is initiated;

        Exclusion Criteria:

          1. Life expectance less than 6 months;

          2. Any chemotherapy, radiotherapy, immunotherapy, biologic, investigational or hormonal
             therapy for treatment of lymphoma within 28 days prior to treatment;

          3. Rituximab, other anti-CD20 mAb (Monoclonal Antibodies) drug treatment, treatment with
             any cell depleting therapies - e.g., anti-CD4 (cluster of differentiation 4) anti-CD5
             (cluster of differentiation 5), anti-CD3 (cluster of differentiation 3), anti-CD19
             (cluster of differentiation 19), anti CD11 (cluster of differentiation 11), anti-CD22
             (cluster of differentiation 11), BLys/BAFF (B Lymphocyte Stimulator/B-cell activating
             factor) within 1,5 years before screening;
Clinical trial NCT02617589 (phase 3, status: active, not recruiting)
Conditions: brain cancer
ICD codes: C71.7, C71.9, C79.31, D33.0, D33.1, D33.2, D49.6
Drugs: nivolumab, temozolomide
SMILES: [H][N]1([H])[C@@H]2CCCC[C@H]2[N]([H])([H])[Pt]11OC(=O)C(=O)O1, CSCC[C@H](N)C(O)=O
Eligibility criteria:

        For more information regarding BMS clinical trial participation, please visit
        www.BMSStudyConnect.com

        Inclusion Criteria:

          -  Males and Females, age ≥ 18 years old

          -  Newly-diagnosed brain cancer or tumor called glioblastoma or GBM

          -  Tumor test result shows MGMT unmethylated type

          -  Karnofsky performance status of ≥ 70 (able to care for self)

        Exclusion Criteria:

          -  Prior treatment for GBM (other than surgical resection)

          -  Any known tumor outside of the brain

          -  Recurrent or secondary GBM

          -  Active known or suspected autoimmune disease

          -  Biopsy with less than 20% of tumor removed
Clinical trial NCT02621892 (phase 3, status: completed)
Conditions: constipation predominant irritable bowel syndrome
ICD codes: K59.00, K59.09, K59.01, K59.02, K59.03, K59.04, K58.1
Drugs: tenapanor, placebo
SMILES: CN1C[C@@H](C2=CC(=CC=C2)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C2=CC(=CC=C2)[C@@H]2CN(C)CC3=C2C=C(Cl)C=C3Cl)C2=C(C1)C(Cl)=CC(Cl)=C2, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  18 to 75 years old

          -  Females must be of non-childbearing potential; If of child-bearing potential, must
             have negative pregnancy test and confirm the use of one of the appropriate means of
             contraception.

          -  Males must agree to use an appropriate method of barrier contraception or have
             documented surgical sterilization

          -  Subject meets definition of IBS-C using Rome III Criteria for the Diagnosis of IBS

          -  A colonoscopy based on AGA guidelines; every 10 years at ≥ 50 years old, or the
             occurrence of any warning signs

        Exclusion Criteria:

          -  Functional diarrhea as defined by Rome III criteria

          -  IBS with diarrhea (IBS-D), mixed IBS (IBS-M), or unsubtyped IBS as defined by Rome III
             criteria

          -  Diagnosis or treatment of any clinically symptomatic biochemical or structural
             abnormality of the GI tract within 6 months prior to screening, or active disease
             within 6 months prior to screening; including but not limited to cancer, inflammatory
             bowel disease, diverticulitis, duodenal ulcer, erosive esophagitis, gastric ulcer,
             pancreatitis (within 12 months of screening), cholelithiasis, amyloidosis, ileus,
             non-controlled GERD, gastrointestinal obstruction, ischemic colitis or carcinoid
             syndrome.

          -  Subject has a history or current evidence of laxative abuse (in the clinical judgment
             of the physician)

          -  Hepatic dysfunction (ALT [SGPT] or AST [SGOT] >2.5 times the upper limit of normal) or
             renal impairment (serum creatinine > 2mg/dL)

          -  Any evidence of or treatment of malignancy (other than localized basal cell, squamous
             cell skin cancer or cancer in situ that has been resected) within the previous year

          -  Any surgery on the stomach, small intestine or colon, excluding appendectomy or
             cholecystectomy (unless within 60 days of screening visit)
Clinical trial NCT02621931 (phase 3, status: completed)
Conditions: migraine
ICD codes: G43.B1, G43.D1, G43.B0, G43.D0, G43.A1, G43.411, G43.419
Drugs: fremanezumab, placebo
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Males or females aged 18 to 70 years, inclusive, with migraine onset at ≤50 years of
             age

          -  Patient signs and dates the informed consent document

          -  Patient has history of migraine according to International Classification of Headache
             Disorders, or clinical judgment suggests a migraine diagnosis

          -  85% e-diary compliance

          -  Total body weight between 99 and 250 lbs, inclusive

               -  Additional criteria apply, please contact the investigator for more information

        Exclusion Criteria:

          -  Clinically significant hematological, cardiac, renal, endocrine, pulmonary,
             gastrointestinal, genitourinary, neurologic, hepatic, or ocular disease, at the
             discretion of the investigator

          -  Evidence or medical history of clinically significant psychiatric issues, including
             any suicide attempt in the past, or suicidal ideation with a specific plan in the past
             2 years

          -  History of clinically significant cardiovascular disease or vascular ischemia (such as
             myocardial, neurological [eg, cerebral ischemia], peripheral extremity ischemia, or
             other ischemic event) or thromboembolic events (arterial or venous thrombotic or
             embolic events), such as cerebrovascular accident (including transient ischemic
             attacks), deep vein thrombosis, or pulmonary embolism

          -  Known infection or history of human immunodeficiency virus, tuberculosis, or chronic
             hepatitis B or C infection

          -  Past or current history of cancer in the last 5 years, except for appropriately
             treated nonmelanoma skin carcinoma

          -  Pregnant or nursing females

          -  History of hypersensitivity reactions to injected proteins, including monoclonal
             antibodies

          -  Participation in a clinical study of a new chemical entity or a prescription medicine
             within 2 months prior to study drug administration or 5 half-lives, whichever is
             longer

               -  Additional criteria apply, please contact the investigator for more information
Clinical trial NCT02627963 (phase 3, status: active, not recruiting)
Conditions: carcinoma, renal cell
ICD codes: C22.0, C4A.9, C7B.1, C4A.0, C4A.31, C4A.51, C4A.8
Drugs: tivozanib hydrochloride, sorafenib
SMILES: COC1=C(OC)C=C2C(OC3=CC(Cl)=C(C=C3)N=C(O)N=C3NOC(C)=C3)=CC=NC2=C1, CNC(=O)C1=NC=CC(OC2=CC=C(NC(=O)NC3=CC(=C(Cl)C=C3)C(F)(F)F)C=C2)=C1
Eligibility criteria:

        Inclusion Criteria:

          -  18 years or older

          -  Subjects with metastatic RCC who have failed 2 or 3 prior systemic regimens, one of
             which includes a VEGFR TKI other than sorafenib or tivozanib.

          -  Histologically or cytologically confirmed RCC with a clear cell component (subjects
             with pure papillary cell tumor or other non-clear cell histologies, including
             collecting duct, medullary, chromophobe, and unclassified RCC are excluded).

          -  Measurable disease per the Response Evaluation Criteria in Solid Tumors (RECIST)
             criteria Version 1.1.

          -  Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

          -  Life expectancy ≥ 3 months.

        Exclusion Criteria:

          -  Prior treatment with sorafenib or tivozanib.

          -  More than 3 prior regimens for metastatic RCC.

          -  Known central nervous system (CNS) metastases other than stable, treated brain
             metastases. Subjects with previously treated brain metastasis will be allowed if the
             brain metastasis has been stable by neuroimaging without steroid treatment for at
             least 3 months following prior treatment (radiotherapy or surgery).

          -  Significant hematologic, gastrointestinal, thromboembolic, vascular, bleeding, or
             coagulation disorders.

          -  Significant serum chemistry abnormalities

          -  Significant cardiovascular disease, including: Active clinically symptomatic left
             ventricular failure,uncontrolled hypertension, myocardial infarction, severe angina,
             or unstable angina within 6 months prior to administration of first dose of study
             drug, history of serious ventricular arrhythmia, cardiac arrhythmias requiring
             anti-arrhythmic medications.

          -  Inadequate recovery from any prior surgical procedure or major surgical procedure
             within 4 weeks prior to administration of first dose of study drug.

          -  Currently active second primary malignancy.
Clinical trial NCT02629159 (phase 3, status: active, not recruiting)
Conditions: rheumatoid arthritis
ICD codes: M06.9, M05.9, M06.08, M06.00, M06.011, M06.012, M06.019
Drugs: placebo for adalimumab, adalimumab, placebo for upadacitinib, upadacitinib
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Adult male or female, at least 18 years old.

          -  Diagnosis of RA for greater than or equal to 3 months.

          -  Subjects must have been on oral or parenteral methotrexate (MTX) therapy greater than
             or equal to 3 months and on a stable prescription of greater than or equal to 15 to 25
             mg/week (or greater than or equal to 10 mg/week in subjects intolerant of MTX at doses
             greater than or equal to 12.5 mg/week) for at least 4 weeks prior to the first dose of
             study drug. In addition all subjects should take a dietary supplement of folic acid or
             folinic acid throughout the study participation.

          -  Meets the following minimum disease activity criteria: greater than or equal to 6
             swollen joints (based on 66 joint counts) and greater than or equal to 6 tender joints
             (based on 68 joint counts) at Screening and Baseline Visits.

          -  At least one of the following at Screening: greater than or equal to 3 bone erosions
             on x-ray OR greater than or equal to 1 bone erosion and a positive rheumatoid factor
             OR greater than or equal to 1 bone erosion and a positive anti-cyclic citrullinated
             peptide autoantibodies.

          -  Subjects with prior exposure to only one biological disease-modifying anti-rheumatic
             drugs (bDMARD) (except adalimumab) may be enrolled (up to 20% of total study
             population) if they have documented evidence of intolerance to the bDMARD or limited
             exposure (less than 3 months), but required washout periods need to be satisfied.

          -  Except for MTX, subject must have discontinued all conventional synthetic
             disease-modifying anti-rheumatic drugs (csDMARDs).

        Exclusion Criteria:

          -  Prior exposure to any Janus kinase (JAK) inhibitor (including but not limited to
             tofacitinib, baricitinib, and filgotinib).

          -  Subjects who have been exposed to adalimumab or who are considered inadequate
             responders to bDMARD therapy as determined by the Investigator.

          -  History of inflammatory joint disease other than RA. History of secondary Sjogren's
             Syndrome is permitted.
Clinical trial NCT02629861 (phase 3, status: completed)
Conditions: migraine
ICD codes: G43.B1, G43.D1, G43.B0, G43.D0, G43.A1, G43.411, G43.419
Drugs: fremanezumab, placebo
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Males or females aged 18 to 70 years, inclusive, with migraine onset at ≤50 years of
             age

          -  Patient signs and dates the informed consent document

          -  Patient has history of migraine according to International Classification of Headache
             Disorders, or clinical judgment suggests a migraine diagnosis

          -  85% e-diary compliance

          -  Total body weight between 99 and 265 lbs, inclusive

               -  Additional criteria apply, please contact the investigator for more information

        Exclusion Criteria:

          -  Clinically significant hematological, cardiac, renal, endocrine, pulmonary,
             gastrointestinal, genitourinary, neurologic, hepatic, or ocular disease, at the
             discretion of the investigator

          -  Evidence or medical history of clinically significant psychiatric issues, including
             any suicide attempt in the past, or suicidal ideation with a specific plan in the past
             2 years

          -  History of clinically significant cardiovascular disease or vascular ischemia (such as
             myocardial, neurological [eg, cerebral ischemia], peripheral extremity ischemia, or
             other ischemic event) or thromboembolic events (arterial or venous thrombotic or
             embolic events), such as cerebrovascular accident (including transient ischemic
             attacks), deep vein thrombosis, or pulmonary embolism

          -  Known infection or history of human immunodeficiency virus, tuberculosis, or chronic
             hepatitis B or C infection

          -  Past or current history of cancer in the last 5 years, except for appropriately
             treated nonmelanoma skin carcinoma

          -  Pregnant or nursing females

          -  History of hypersensitivity reactions to injected proteins, including monoclonal
             antibodies

          -  Participation in a clinical study of a new chemical entity or a prescription medicine
             within 2 months or 5 half-lives, whichever is longer

               -  Additional criteria apply, please contact the investigator for more information
Clinical trial NCT02629965 (phase 3, status: completed)
Conditions: pulmonary disease, chronic obstructive
ICD codes: J44.9, J44.1, J44.0
Drugs: tiotropium, olodaterol, tiotropium
SMILES: [H][C@]12O[C@@]1([H])[C@]1([H])C[C@@]([H])(C[C@@]2([H])[N+]1(C)C)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1, COC1=CC=C(CC(C)(C)NC[C@H](O)C2=C3OCC(=O)NC3=CC(O)=C2)C=C1, [H][C@]12O[C@@]1([H])[C@]1([H])C[C@@]([H])(C[C@@]2([H])[N+]1(C)C)OC(=O)C(O)(C1=CC=CS1)C1=CC=CS1
Eligibility criteria:

        Inclusion criteria:

          -  All patients must sign an informed consent consistent with International Conference on
             Harmonization - Good Clinical Practice (ICH-GCP) guidelines prior to participation in
             the trial, which includes medication washout and restrictions.

          -  All patients must have a diagnosis of chronic obstructive pulmonary disease (COPD) and
             must meet the following spirometric criteria:

        Patients must have relatively stable airway obstruction with a post-bronchodilator Forced
        expiratory volume in one second (FEV1) < 80% of predicted normal and post-bronchodilator
        FEV1/forced vital capacity (FVC) < 70% at Visit 1.

          -  Male or female patients, aged >= 40 years.

          -  Patients must be current or ex-smokers with a smoking history of more than 10 pack
             years. Patients who have never smoked cigarettes must be excluded.

          -  Patients with score on the modified Medical Research Council (mMRC) >= 1.

          -  Patients who walk < 400 meters of 6MWT and have a score on the modified Borg >= 4 at
             the end of 6 minute walk test (6MWT) at Visit 2.

          -  Patients must be able to perform technically acceptable pulmonary function tests
             (spirometry), to use the physical activity monitor and must be able to complete 6MWT
             during the study period as required in the protocol.

          -  Patients must be able to inhale medication in a competent manner from the RESPIMAT
             Inhaler and from a metered dose inhaler.

        Exclusion criteria:

          -  Patients with a significant disease other than COPD; a significant disease is defined
             as a disease which, in the opinion of the investigator, may put the patient at risk
             because of participation in the study, influence the results of the study and cause
             concern regarding the patient's ability to participate in the study.

          -  Patients with clinically relevant abnormal baseline haematology, blood
             chemistry,urinalysis or creatinine > x2 upper limit of normal (ULN) will be excluded
             regardless of clinical condition (a repeat laboratory evaluation can be conducted if
             deemed necessary by the investigator).

          -  Patients with a current documented diagnosis of asthma. For patients with allergic
             rhinitis or atopy, source documentation is required to verify that the patient does
             not have asthma.

          -  Further exclusion criteria apply