Clinical trial NCT02777489 (phase 2, status: terminated)
Conditions: obesity
ICD codes: E66.8, E66.9, E66.1, O99.214, O99.215, O99.210, O99.211
Drugs: perindopril
SMILES: [H][C@]12C[C@H](N(C(=O)[C@H](C)N[C@@H](CCC)C(=O)OCC)[C@@]1([H])CCCC2)C(O)=O
Reason stopped: 
    unproven hypothesis
  
Eligibility criteria:

        Inclusion Criteria:

          -  Written informed consent;

          -  Man or woman with 18 years or more;

          -  Body Mass Index (BMI) between 30.0 to 40.0 kg/m2;

          -  Willingness and ability to comply with the study requirements;

          -  Ability to understand and sign informed consent;

          -  If woman of childbearing potential, she agrees to adopt effective contraceptive
             methods.

        Exclusion Criteria:

          -  Pregnant or breastfeeding women;

          -  History of obesity with a known cause (e.g., hypothyroidism, Cushing's disease);

          -  Under treatment with perindopril or other angiotensin converting enzyme (ACE)
             inhibitor, or with an angiotensin receptor blocker (ARB) or a renin inhibitor;

          -  Hypertension diagnosed at screening;

          -  Significant variation in weight (more 10%) in the past 3 months before screening
             visit;

          -  History of anorexia nervosa, bulimia, or binge-eating disorder;

          -  Systolic blood pressure <110 mmHg;

          -  History of hypersensitivity to perindopril, or related compounds, or to any of the
             inactive ingredients;

          -  History of angioedema associated with previous ACE inhibitor therapy;

          -  History of idiopathic or hereditary angioedema;

          -  Treatment with concomitant medication affecting weight loss (e.g. metformin) starting
             within the 3 months prior to screening;

          -  Treatment with concomitant medication that might interfere with the absorption,
             distribution, metabolism or elimination of perindopril, or, is likely to compromise
             the safety of subject (e.g. diuretics in patients with salt and/or volume depletion,
             insulin or oral antidiabetics in patients prone to develop hypoglycemic episodes,
             lithium, vasodilators in patients prone to develop hypotension, tricyclic
             antidepressants, antipsychotics, anesthetics, gold, potassium supplements or
             potassium-containing salt substitutes);

          -  Treatment with any investigational drug or device within 1 month before the start of
             the run-in period;

          -  Moderate to severe hepatic impairment (Child-Pugh score ≥ 7) or moderate to severe
             renal impairment (glomerular filtration rate (GFR) ≤ 59 ml/min);

          -  Unstable coronary artery disease;

          -  Aortic and mitral valve stenosis / hypertrophic cardiomyopathy

          -  Hemodialysis patients;

          -  Kidney transplantation;

          -  Anaphylactoid reactions during low-density lipoproteins (LDL) apheresis;

          -  Neutropenia/agranulocytosis/thrombocytopenia/anemia;

          -  Patients undergoing major surgery or during anesthesia with agents that produce
             hypotension;

          -  Hyperkalemia;

          -  Any other condition or therapy that the study physician considers to make the subject
             unsuitable for this study