Clinical trial NCT02576977 (phase 3, status: terminated)
Conditions: multiple myeloma
ICD codes: C90.01, C90.02, C90.00
Drugs: pomalidomide, dexamethasone
SMILES: [H][C@@]12C[C@@H](C)[C@](O)(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C, C[C@@H](O[C@H]1OCCN(CC2=NNC(=O)N2)[C@H]1C1=CC=C(F)C=C1)C1=CC(=CC(=C1)C(F)(F)F)C(F)(F)F
Reason stopped: 
    the study was terminated early due to business reasons
  
Eligibility criteria:

        Inclusion Criteria:

          -  Has a confirmed diagnosis of active multiple myeloma and measurable disease

          -  Must have undergone prior treatment with ≥2 treatment lines of anti-myeloma therapy
             and must have failed last line of treatment (refractory to last line of treatment)

          -  Prior anti-myeloma treatments must have included an immunomodulatory drug (IMiD) AND
             proteasome inhibitor alone or in combination and participant must have failed therapy
             with an IMiD OR proteasome inhibitor

          -  Has performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
             Performance Scale

          -  Female participants of childbearing potential must have 2 negative urine human
             chorionic gonadotropin tests within 10 to 14 days and within 24 hours prior to
             receiving study medication

          -  Female participants of childbearing potential and male participants must agree to use
             adequate contraception 28 days prior to study start and continuing for up to 28 days
             after the last dose of pomalidomide (or 120 days after the last dose of pembrolizumab)

        Exclusion Criteria:

          -  Has had prior anti-myeloma therapy within 2 weeks prior to study start and has not
             recovered (i.e., ≤ Grade 1 or at Baseline) from adverse events due to a previously
             administered agent

          -  Has undergone prior allogeneic hematopoietic stem cell transplantation within the last
             5 years. (Participants who have had a transplant greater than 5 years ago are eligible
             as long as there are no symptoms of Graft versus Host Disease [GVHD]).

          -  Has received autologous stem cell transplant (auto-SCT) within 12 weeks before the
             first infusion or is planning for or is eligible for auto-SCT

          -  Has received previous therapy with pomalidomide

          -  Has peripheral neuropathy ≥ Grade 2

          -  Has a known additional malignancy that is progressing or requires active treatment
             within the last 5 years (except for basal cell carcinoma of the skin, squamous cell
             carcinoma of the skin, or in situ cervical cancer that has undergone potentially
             curative therapy)

          -  Has a history of (non-infectious) pneumonitis that required steroids or current
             pneumonitis

          -  Has received prior therapy with an anti-programmed cell death 1 receptor (anti-PD-1),
             antiprogrammed death-ligand 1 (anti-PD-L1), anti-PD-L2, anti-CD137, or anti-cytotoxic
             T-lymphocyte-associated antigen-4 (CTLA-4) antibody (including ipilimumab or any other
             antibody or drug specifically targeting T-cell costimulation or checkpoint pathways)

          -  Is pregnant or breast-feeding