Clinical trial NCT03116971 (phase 1, status: terminated)
Conditions: small cell lung cancer
ICD codes: C78.00, C78.01, C78.02, D14.30, D14.31, D14.32, C34.2
Drugs: m3814, cisplatin, etoposide
SMILES: [H][C@@]12N(C)C3=CC(OC)=C(C=C3[C@@]11CCN3CC=C[C@](CC)([C@@]13[H])[C@@]([H])(OC(C)=O)[C@]2(O)C(=O)OC)[C@]1(C[C@@]2([H])CN(CC(CC)=C2)CC2=C1NC1=CC=CC=C21)C(=O)OC, OCCOCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
Reason stopped: 
    enrollment in the study was prematurely terminated due to recruitment challenges and not due to
    concerns of safety for the participants.
  
Eligibility criteria:

        Inclusion Criteria:

        To be eligible for the study (Phase Ib and Phase II) the participant must fulfill all of
        the following criteria:

          -  Male or female participants at least 18 years of age

          -  Histological or cytological diagnosis of SCLC

          -  Extensive disease (ie, disease beyond ipsilateral hemithorax, which may include
             malignant pleural or pericardial effusion or hematogenous metastases [Tany, Nany,
             M1a/b; T3-T4, Nany, M0, due to multiple lung nodules or extent of disease that
             precludes a tolerable radiation field, as judged by the Investigator])

          -  Participants eligible for first line platinum-based chemotherapy

          -  Measurable or evaluable disease according to RECIST v1.1

          -  Eastern Cooperative Oncology Group performance status (ECOG PS) less than equals to
             (<=) 2

          -  Life expectancy of greater than equals to (≥) 3 months

          -  Female participants of childbearing potential and male participants with female
             partners of childbearing potential must be willing to avoid pregnancy Note: Other
             protocol defined criteria could apply.

        Exclusion Criteria:

        Participants are not eligible for the study if they fulfill any of the following exclusion
        criteria:

          -  Prior anticancer therapy for extensive disease (ED) SCLC including experimental
             agents.

          -  Concurrent use of other anticancer therapy including any investigational agent within
             28 days prior to the first dose of the investigational drug M3814.

          -  Extensive prior radiotherapy (RT) on more than 30% of bone marrow reserves (by
             Investigator judgment)

          -  Prior bone marrow/stem cell transplantation within 5 years before study start (Phase
             II only)

          -  Major surgical intervention within 28 days prior to the first dose of investigational
             drug administration. Intervention(s) to establish the diagnosis for SCLC is permitted
             within 28 days as long as participants are cleared by the medical and surgical teams.

          -  Poor vital organ functions defined as:

          -  Bone marrow impairment as evidenced by hemoglobin less than (<) 9.0 gram per deci
             liter (g/dL) (5.7 micromole per liter (μmol/L)), absolute neutrophil count < 1.5 ×
             109/L, platelets < 100 × 109/L

          -  Renal impairment as evidenced by calculated creatinine clearance < 60 mL/minutes (min)
             (according to the Cockcroft-Gault formula)

          -  Liver function abnormality as defined by total bilirubin greater than (>) 1.5 × upper
             limit of normal (ULN) or aspartate aminotransferase (AST)/alanine aminotransferase
             (ALT) > 2.5 × ULN (participants with liver involvement: a maximum of AST/ALT 5 × ULN)

          -  Contraindication to the use of etoposide or cisplatin

          -  Participants currently receiving (or unable to stop using prior to receiving the first
             dose of investigational drug) medications or herbal supplements known to be potent
             inhibitors of cytochrome P450 (CYP) 3A and CYP2C19 (unless treatment can be
             discontinued at least 1 week prior to receiving the first dose of investigational
             drug) or potent inducers of CYP3A and CYP2C19 (unless treatment can be discontinued at
             least 3 weeks prior to receiving the first dose of investigational drug). Note: Other
             protocol defined criteria could apply.