Clinical trial NCT02418689 (phase 2, status: active, not recruiting)
Conditions: metastatic breast cancer
ICD codes: C79.81, D24.1, D24.2, D24.9, D49.3, C44.501, D48.60
Drugs: nov120101 (poziotinib)
SMILES: COC1=C(OC2CCN(CC2)C(=O)C=C)C=C2C(NC3=CC=C(Cl)C(Cl)=C3F)=NC=NC2=C1
Eligibility criteria:

        Inclusion Criteria:

          1. Who give agreement to the collection of tumor tissue specimen suitable for biomarker
             research

          2. ECOG performance status ≤ 2

          3. Who received following treatments as Taxane-based chemotherapy and at least two
             HER2-targeted* therapy including Trastuzumab.

             * lapatinib, T-DM1 (trastuzumab emtansine), pertuzumab

          4. Adequate hematological, hepatic and renal functions

        Exclusion Criteria:

          1. Who received NOV120101 prior to participation in this study

          2. Patients expected to exhibit hypersensitivity to IP or its components

          3. Any other concurrent chemotherapies

          4. Concurrent or prior radiotherapy within 4 weeks before study participation. However,
             patients with additional lesions other than the major lesion who completed and
             recovered from all treatment-related toxicities after radiotherapy in a limited area
             as a palliative therapy are allowed to participate in the study

          5. History of symptomatic or unstable angina and congestive heart failure; arrhythmia
             requiring medications; or clinically significant myocardial infarction or other
             cardiac diseases within 6 months before study participation for which any
             related-significant risks are expected

          6. Patients whose left ventricle ejection fraction (LVEF) is below the institutional
             lower limit of normal. However, if no lower limit of normal is defined in the site,
             the lower limit or normal is 50%.

          7. Concurrent active hepatic or biliary disease (with exception of Gilbert's syndrome,
             asymptomatic gallstones, liver metastases or stable chronic liver diseases)

          8. History or concurrent ongoing/active infection, or uncontrolled diseases including,
             but not limited to, psychiatric illness/social situations which may limit the
             compliance with study procedures

          9. Prior chemo-, immuno-, or surgical therapy within 3 weeks, or hormone therapy within 1
             week before IP administration

         10. History of primary malignancies other than breast cancer.

         11. Patients with central nervous system (CNS) metastases.

         12. Patients receiving or expected to receive bisphosphonate for prophylactic use without
             any bone-related diseases during the trial, for the exception of the treatment for
             bone metastases or osteoporosis initiated prior the IP administration.

         13. Clinically significant or recent acute gastrointestinal disorders with diarrhea as a
             major symptom

         14. Who are unstable or with unresolved severe adverse event(s)

         15. Pregnancy or breast-feeding

         16. Women of childbearing potential or men who are unwilling to use adequate contraception
             or be abstinent during the trial and for at least 2 months after the end of treatment