Clinical trial NCT02428270 (phase 2, status: active, not recruiting)
Conditions: pancreatic cancer, adenocarcinoma
ICD codes: C25.3, C22.0, C22.1, C4A.9, C7B.1, D09.9, C4A.0, C4A.31
Drugs: gsk2256098, trametinib
SMILES: CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=CC=C(I)C=C1F)C1=CC(NC(C)=O)=CC=C1
Eligibility criteria:

        Inclusion Criteria:

          -  Male or female, 18 years or older, able to give written consent

          -  Pancreatic adenocarcinoma that is not responsive to standard therapies or for which
             there is no approved or curative therapy or for patients who refuse standard therapy

          -  Have clinical, radiographic, or serologic progression after one prior line of
             chemotherapy for advanced disease. Patients who have received two or more prior lines
             of chemotherapy for advanced disease are not eligible.

          -  Performance Status score of 0 or 1

          -  Measureable disease by RECIST version 1.1

          -  Able to swallow and retain oral medication

          -  Have malignant disease that is amenable to biopsy and agree to collection of mandatory
             tumor biopsy samples.

          -  Agrees to use contraception

          -  Not pregnant

          -  Adequate organ system function

        Exclusion Criteria:

          -  Chemotherapy, radiotherapy, immunotherapy, or other anti-cancer therapy including
             investigational drugs within 28 days or 5 half lives. No prior MEK inhibitor, RAF
             inhibitors or a FAK inhibitors

          -  Current use of a prohibited medication

          -  Unresolved toxicity greater than Grade 1 from previous anticancer therapy unless the
             ongoing toxicity will not introduce additional risk factors and will not interfere
             with the study procedures.

          -  Presence of active GI disease or other condition that could affect gastrointestinal
             absorption or predisposed to GI ulceration

          -  Evidence of mucosal or internal bleeding

          -  Anticoagulation with warfarin

          -  Major surgery within the last four weeks

          -  Malignancies related to HIV or HBV/HCV

          -  Known active infection requiring parenteral or oral anti-infective treatment

          -  Leptomeningeal disease.

          -  Brain metastases

          -  QTcF interval ≥ 480 msecs

          -  History or evidence of current clinically significant uncontrolled arrhythmias

          -  History of acute coronary syndromes, myocardial infarction, coronary angioplasty, or
             stenting or bypass grafting within six months of screening.

          -  Class II, III, or IV heart failure as defined by the New York Heart Association (NYHA)
             functional classification system.

          -  Other clinically significant ECG abnormalities

          -  Intra-cardiac defibrillators.

          -  Presence of cardiac metastases.

          -  Serious or unstable pre-existing medical, psychiatric, or other condition that could
             interfere with patient's safety or providing informed consent.

          -  Known immediate or delayed hypersensitivity to any of the components of the study
             treatment(s).

          -  Evidence of severe or uncontrolled systemic diseases

          -  Pregnant or lactating

          -  History of retinal vein occlusion

          -  History of interstitial lung disease or pneumonitis