araag2/HINT huggingface dataset:
Clinical trial NCT02325466 (phase 3, status: completed)
Conditions: peripheral artery disease, type 2 diabetes
ICD codes: A18.2, H11.043, H11.053, H18.463, H35.40, H81.393, I73.9, E11.65, E11.9, E11.21, E11.36, E11.41, E11.42, E11.44
Drugs: aspirin, ticagrelor, aspirin placebo, ticagrelor placebo
SMILES: CC(=O)OC1=CC=CC=C1C(O)=O, [H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl, CC(=O)OC1=CC=CC=C1C(O)=O, [H][C@@](N1CCC2=C(C1)C=CS2)(C(=O)OC)C1=CC=CC=C1Cl
Eligibility criteria:

        Inclusion Criteria:

          -  Female or male aged ≥ 35 years

          -  Type 2 diabetes mellitus

          -  Symptomatic PAD

          -  Ankle-brachial index ≤ 0.85 or calcified blood vessels with toe-brachial index ≤ 0.6
             and/or abnormal post-exercise ankle-brachial index

          -  Prior surgical or percutaneous intervention of the peripheral arteries ≥12 months
             previously with a residual stenoses of ≥50% in a non-dilated artery.

        Exclusion Criteria:

          -  Subject is pregnant or breast-feeding

          -  Planned revascularization or amputation

          -  Known bleeding disorder

          -  History of intracranial hemorrhag3

          -  Considered at risk of hemorrhagic events

          -  Hypersensitivity or allergic reactions to aspirin

          -  Concomitant use of anticoagulants such as warfarin, dabigatran, factor Xa inhibitors
             or antiplatelet drugs such as clopidogrel, dipyridamole and sulfapyridine

          -  Subject has a condition or circumstance which would prevent them from adhering to
             treatment regimens

          -  Subject has active infection

          -  Subject has an anemia

          -  Subject has given blood or received a blood transfusion at any point during the study

          -  Subject has polycythemia vera or any hyperviscosity syndrome

          -  Subjects with Waldenstrom's macroglobulinemia who have an increased risk of
             hyperviscosity syndrome

          -  Subject has history of severe liver disease, obstructive liver disease such as primary
             biliary cirrhosis or end-stage renal disease (eGFR <30 mL/min/m2)

          -  Family members or employees of the investigator or study centers involved in the study

          -  Subject has poor diabetes or hypertension control (systolic blood pressure ≥ 180 mmHg
             or diastolic blood pressure ≥ 100 mmHg)
Clinical trial NCT02325791 (phase 3, status: completed)
Conditions: respiratory syncytial virus infections
ICD codes: R09.2, A15.7, A15.8, A15.9, J98.9, R06.03, J12.1
Drugs: suptavumab 30 mg/kg, placebo matched to suptavumab, suptavumab 30 mg/kg- 1 dose, suptavumab 30 mg/kg - 2 doses
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Key Inclusion Criteria:

          1. Preterm, otherwise healthy male or female infant who is ≤6 months of age at the time
             of the first dose (i.e., infant must be treated on or before their 6 month birthday)

          2. Gestational age is ≤35 weeks, 6 days at birth

          3. Parent(s) or legal guardian(s) of the infant is able to understand the study
             requirements and willing to provide informed consent

        Key Exclusion Criteria:

          1. Eligible, recommended and have access to receive palivizumab per AAP or other local
             guidelines, standard practice, or by their healthcare provider

          2. History of CLD defined as requirement of supplemental oxygen for 28 days after birth

          3. Known hemodynamically significant congenital heart disease

          4. Known immunodeficiency, neuromuscular disease, or congenital abnormalities of the
             airway

          5. Known renal or hepatic dysfunction

          6. Major congenital malformations, including congenital cleft palate, cytogenetic
             abnormalities, or serious chronic disorders

          7. Known or suspected impairment of immunological functions or autoimmune diseases

          8. History of anaphylaxis

          9. Previously received palivizumab or any other investigational RSV prophylaxis or
             vaccine product

         10. Previous reaction to IV immunoglobulin, blood products or other foreign proteins,
             including vaccines and monoclonal antibodies

        Note: Other inclusion and exclusion criteria apply
Clinical trial NCT02326220 (phase 3, status: completed)
Conditions: heterozygous familial hypercholesterolemia
ICD codes: E78.01, E78.00, Z83.42
Drugs: placebo, alirocumab
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          1. Men and women ≥18 years of age at the time of the screening visit

          2. Diagnosis of HeFH (Heterozygous familial hypercholesterolemia)

          3. Currently undergoing LDL (low-density lipoprotein) apheresis therapy QW (weekly) or
             Q2W (every 2 weeks) or at least 8 weeks prior to the screening visit

        Exclusion Criteria:

          1. Homozygous FH (familial hypercholesterolemia)

          2. Background medical LMT (lipid-modifying therapy) (if applicable) that has not been
             stable for at least 8 weeks prior to the screening visit

          3. LDL apheresis schedule/ apheresis settings that have not been stable for at least 8
             weeks prior to the screening visit

          4. An LDL apheresis schedule other than QW to Q2W

          5. Initiation of a new exercise program or exercise that has not remained stable within 8
             weeks prior to the screening visit (week -2)

          6. Initiation of a new diet or a diet that has not been stable within 8 weeks prior to
             the screening visit (week -2)

          7. Use of nutraceuticals or over-the-counter therapies known to affect lipids, at a
             dose/amount that has not been stable for at least 8 weeks prior to the screening visit
             (week -2), or between the screening and randomization visit

          8. Presence of any clinically significant uncontrolled endocrine disease known to
             influence serum lipids or lipoproteins

          9. Known history of a positive test for human immunodeficiency virus

         10. Use of any active investigational drugs within 1 month or 5 half-lives of screening,
             whichever is longer

         11. Patients who have been treated with at least 1 dose of alirocumab or any other
             anti-PCSK9 monoclonal antibody in any other clinical studies

         12. Pregnant or breastfeeding women
Clinical trial NCT02327182 (phase 3, status: terminated)
Conditions: alzheimer's disease
ICD codes: G30.8, G30.9, G30.0, G30.1
Drugs: mt-4666
SMILES: ClC1=C2SC(=CC2=CC=C1)C(=O)N[C@H]1CN2CCC1CC2
Reason stopped: 
    this study was terminated due to the benefit-risk balance of mt-4666.
  
Eligibility criteria:

        Inclusion Criteria:

          -  Probable Alzheimer's disease consistent with the National Institute on Aging and the
             Alzheimer's Association Criteria for Diagnosis of Alzheimer's Disease (McKhann et al.
             2011).

          -  MMSE score of ≥ 14 and ≤ 24 at the screening and ≥ 12 and ≤ 26 at the baseline.

          -  Modified Hachinski Ischemic Score (mHIS) ≤ 4 at the screening

          -  Appropriate caregiver available

          -  Subject living at home or in facilities who do not require continuous (24-hour)
             nursing care.

        Exclusion Criteria:

          -  Diagnosis of any other disease which may cause dementia

          -  Diagnosis of major depressive disorder as defined by Diagnostic and Statistical Manual
             of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) within last five years

          -  History of or current diagnosis of any psychosis

          -  History of myocardial infarction or unstable angina within six months before screening

          -  History of cerebrovascular disorder within 18 months before screening

          -  complication of hepatic disorder or renal dysfunction
Clinical trial NCT02332590 (phase 3, status: completed)
Conditions: rheumatoid arthritis
ICD codes: M06.9, M05.9, M06.08, M06.00, M06.011, M06.012, M06.019
Drugs: sarilumab, adalimumab, placebo (for sarilumab), placebo (for adalimumab)
SMILES: O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion criteria:

          -  Diagnosis of RA ≥3 months duration.

          -  American College of Rheumatology (ACR) Class I-III functional status.

          -  Active RA was defined as:

        At least 6 of 66 swollen joints and 8 of 68 tender joints, high sensitivity C-reactive
        protein (hs-CRP) ≥8 mg/L or ESR ≥28 mm/H, and DAS28-ESR >5.1.

          -  Participants as per Investigator judgment were either intolerant of, or considered
             inappropriate candidates for continued treatment with MTX, or after at least 12 weeks
             of continued treatment with MTX, or inadequate responders treated with an adequate MTX
             dose for at least 12 weeks.

        Exclusion criteria:

          -  Age <18 years or the legal age of consent in the country of the study site, whichever
             was higher.

          -  Current treatment with disease-modifying antirheumatic drug (DMARDs)/immunosuppressive
             agents including MTX, cyclosporine, mycophenolate, tacrolimus, gold, penicillamine,
             sulfasalazine or hydroxychloroquine within 2 weeks prior to the baseline
             (Randomization Visit) or azathioprine, cyclophosphamide within 12 weeks prior to
             baseline (Randomization Visit) or leflunomide within 8 weeks prior to the
             Randomization Visit, or 4 weeks after cholestyramine washout.

          -  Treatment with any prior biologic agent, including anti-interleukin 6 (IL-6), IL-6
             receptor (IL-6R) antagonists, and prior treatment with a Janus kinase inhibitor.

          -  Use of parenteral corticosteroids or intra-articular corticosteroids within 4 weeks
             prior to screening.

        The above information was not intended to contain all considerations relevant to a
        participant's potential participation in a clinical trial.
Clinical trial NCT02333071 (phase 3, status: completed)
Conditions: hypoactive sexual desire disorder
ICD codes: F52.0
Drugs: bremelanotide
SMILES: CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=CC=CC=C23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CN=CN2)NC1=O)C(O)=O
Eligibility criteria:

        Main Inclusion Criteria:

          -  Has met diagnostic criteria for HSDD for at least 6 months

          -  Is willing and able to understand and comply with all study requirements

          -  Has a normal pelvic examination at screening

        Main Exclusion Criteria:

          -  Subjects should be generally healthy premenopausal females with no psychological,
             gynecological or urological conditions which might contribute to the sexual
             dysfunction, compromise study participation, or confound interpretation of the study
             results

          -  Not currently under treatment for the sexual dysfunction and willing to forego other
             treatments through the course of the clinical trial
Clinical trial NCT02338960 (phase 3, status: completed)
Conditions: hypoactive sexual desire disorder
ICD codes: F52.0
Drugs: bremelanotide, placebo
SMILES: CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=CC=CC=C23)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CN=CN2)NC1=O)C(O)=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Main Inclusion Criteria:

          -  Has met diagnostic criteria for HSDD for at least 6 months

          -  Is willing and able to understand and comply with all study requirements

          -  Has a normal pelvic examination at screening

        Main Exclusion Criteria:

          -  Subjects should be generally healthy premenopausal females with no psychological,
             gynecological or urological conditions which might contribute to the sexual
             dysfunction, compromise study participation, or confound interpretation of the study
             results

          -  Not currently under treatment for the sexual dysfunction and willing to forego other
             treatments through the course of the clinical trial
Clinical trial NCT02343458 (phase 3, status: completed)
Conditions: chronic obstructive pulmonary disease
ICD codes: J44.9, J44.1, J44.0
Drugs: gff mdi (pt003), ff mdi (pt005), gp mdi (pt001), placebo mdi
SMILES: C[N+]1(C)CCC(C1)OC(=O)C(O)(C1CCCC1)C1=CC=CC=C1, C[N+]1(C)CCC(C1)OC(=O)C(O)(C1CCCC1)C1=CC=CC=C1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Non-child bearing potential (ie, physiologically incapable of becoming pregnant,
             including any female who is 2 years post-menopausal); or Child bearing potential, has
             a negative serum pregnancy test at Visit 1, and agrees to acceptable contraceptive
             methods used consistently and correctly for the duration of the study.

          -  Subjects with an established clinical history of COPD as defined by the American
             Thoracic Society (ATS)/European Respiratory Society (ERS).

          -  Current or former smokers with a history of at least 10 pack-years of cigarette
             smoking.

          -  Forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) ratio of <0.70.

          -  FEV1 must be <80% predicted normal value calculated using the Third National Health
             and Nutrition Examination Survey (NHANES III) reference equations. (Or reference norms
             applicable to other regions).

        Exclusion Criteria:

          -  Significant diseases other than COPD, ie, disease or condition which, in the opinion
             of the Investigator, may put the subject at risk because of participation in the study
             or may influence either the results of the study or the subject's ability to
             participate in the study.

          -  Women who are pregnant or lactating or women of childbearing potential who are not
             using an acceptable method of contraception.

          -  Subjects, who in the opinion of the Investigator, have a current diagnosis of asthma.

          -  Subjects who have been hospitalized due to poorly controlled COPD within 3 months
             prior to Visit 1 (Screening) or during the Screening Period (Visit 1 to Visit 4).

          -  Subjects who have poorly controlled COPD, defined as acute worsening of COPD that
             requires treatment with oral corticosteroids or antibiotics within 6 weeks prior to
             Visit 1 (Screening) or during the Screening Period (Visit 1 to Visit 4).

          -  Subjects with a diagnosis of angle closure glaucoma will be excluded, regardless of
             whether or not they have been treated. Subjects with a diagnosis of open angle
             glaucoma who have intraocular pressure controlled with medication(s) are eligible.

          -  Subjects who have a history of hypersensitivity to β2-agonists, glycopyrronium or
             other muscarinic anticholinergics, or any component of the MDI.
Clinical trial NCT02344004 (phase 3, status: completed)
Conditions: mycobacterium infections, nontuberculous
ICD codes: A31.2
Drugs: lai (liposomal amikacin for inhalation) 590 mg
SMILES: NCC[C@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]1O[C@H](CO)[C@@H](O)[C@H](N)[C@H]1O
Eligibility criteria:

        Inclusion Criteria:

          1. Be continually positive for MAC on sputum culture while adhering to a multi-drug
             treatment regimen for a minimum duration of 6 months which is either ongoing or was
             completed no more than 12 months before screening

          2. Be diagnosed with MAC NTM lung infection with evidence of nodular bronchiectasis
             and/or fibrocavitary disease by chest CT

          3. Be willing to adhere to multi-drug treatment regimen during the course of the study

        Exclusion Criteria:

          1. Patients with cystic fibrosis

          2. Positive pregnancy test or lactation at screening. All women of child bearing
             potential will be tested. Women not of childbearing potential are defined as
             postmenopausal (i.e., amenorrheic for at least 1 year), or surgically or naturally
             sterile.

          3. Active pulmonary tuberculosis requiring treatment at screening

          4. History of lung transplantation

          5. Prior exposure to LAI (including clinical study).
Clinical trial NCT02346227 (phase 3, status: completed)
Conditions: uterine cervical dysplasia, papillomavirus infections
ICD codes: Q61.4, Q77.5, Q77.6, Q77.7, Q78.5, I77.3, K62.82
Drugs: av2, placebo
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Sexually-active women

          -  Women with intact uterine cervix

          -  Voluntary written informed consent to participate in the study

        Exclusion Criteria:

          -  Virgin women

          -  Pregnant or breast-feeding women, and women in the post-partum period

          -  Subject is already diagnosed with cervical cancer

          -  Medical history of any severe diseases like hepatitis, renal or liver dysfunction,
             cardiovascular, gastrointestinal, malignant tumor, or psychiatric disorders etc.,
             which might influence the assessments or conduct of the trial by the discretion of the
             investigator

          -  Intake or application of antivirals or other prohibited concomitant medication within
             30 days prior to application of AV2®, or patients who plan to take such drugs during
             the trial

          -  Known or suspected allergic or adverse response to the investigational product AV2 or
             its components (olive oil or d-limonene)

          -  Inability to follow the study protocol
Clinical trial NCT02347657 (phase 3, status: completed)
Conditions: cystic fibrosis
ICD codes: E84.9, Z14.1, E84.0, E84.11, E84.8, E84.19, P09.4
Drugs: vx-661 plus ivacaftor combination, ivacaftor, vx-661 plus ivacaftor combination placebo, ivacaftor placebo
SMILES: CC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)C, CC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)C, CC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)C, CC(C)(C)C1=CC(=C(O)C=C1NC(=O)C1=CNC2=CC=CC=C2C1=O)C(C)(C)C
Eligibility criteria:

        Inclusion Criteria:

          -  Homozygous for the F508del CFTR mutation, genotype to be confirmed at the Screening
             Visit

          -  Confirmed diagnosis of CF defined as a sweat chloride value ≥60 mmol/L by quantitative
             pilocarpine iontophoresis

          -  Forced expiratory volume at one second (FEV1) ≥40% and ≤90% of predicted normal for
             age, sex, and height during screening

          -  Stable CF disease as judged by the investigator

          -  Willing to remain on a stable CF medication regimen through Week 24 or, if applicable,
             the Safety Follow up Visit

        Exclusion Criteria:

          -  History of any comorbidity that, in the opinion of the investigator, might confound
             the results of the study or pose an additional risk in administering study drug to the
             participant.

          -  An acute upper or lower respiratory infection, pulmonary exacerbation, or changes in
             therapy (including antibiotics) for pulmonary disease within 28 days before Day 1
             (first dose of study drug)

          -  Pregnant or nursing females (females of childbearing potential must have a negative
             pregnancy test at Screening and Day 1)

          -  Sexually active participants of reproductive potential who are not willing to follow
             the contraception requirements
Clinical trial NCT02348593 (phase 3, status: completed)
Conditions: narcolepsy
ICD codes: G47.411, G47.419, G47.421, G47.429
Drugs: jzp-110, placebo oral tablet
SMILES: CC1=CC(O)=CC(C)=C1Cl
Eligibility criteria:

        Major Inclusion Criteria:

          1. Males and females between 18 and 75 years of age, inclusive

          2. Diagnosis of narcolepsy according to ICSD-3 or DSM-5 criteria

          3. Body mass index from 18 to <45 kg/m2

          4. Consent to use a medically acceptable method of contraception

          5. Willing and able to provide written informed consent

        Major Exclusion Criteria:

          1. Female subjects who are pregnant, nursing, or lactating

          2. Moderate or severe sleep apnea on the baseline PSG.

          3. Any other clinically relevant medical, behavioral, or psychiatric disorder other than
             narcolepsy that is associated with excessive sleepiness

          4. History or presence of bipolar disorder, bipolar related disorders, schizophrenia,
             schizophrenia spectrum disorders, or other psychotic disorders according to DSM-5
             criteria

          5. History or presence of any acutely unstable medical condition, behavioral or
             psychiatric disorder (including active suicidal ideation), or surgical history that
             could affect the safety of the subject or interfere with study efficacy, safety, PK
             assessments, or the ability of the subject to complete the trial per the judgment of
             the Investigator

          6. History of bariatric surgery within the past year or a history of any gastic bypass
             procedure

          7. Presence or history of significant cardiovascular disease

          8. Use of any over-the-counter (OTC) or prescription medications that could affect the
             evaluation of excessive sleepiness

          9. Use of any medications that could affect the evaluation of cataplexy

         10. Received an investigational drug in the past 30 days or five half-lives (whichever is
             longer)

         11. Previous exposure to or participation in a previous clinical trial of JZP-110
             (ADX-N05, R228060, YKP10A)

         12. History of phenylketonuria (PKU) or history of hypersensitivity to
             phenylalanine-derived products