Clinical trial NCT03033784 (phase 2, status: completed)
Conditions: autism, autism spectrum disorder
ICD codes: Z13.41, Z16.12
Drugs: 8 international units (iu) of oxytocin, 24iu of oxytocin, 48iu of oxytocin, placebo
SMILES: [H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C)OC, [H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C)OC, [H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C)OC, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria for ASD Participants:

          -  Have an ASD diagnosis based on the Autism Diagnostic Observation Schedule (ADOS) and
             Autism Diagnostic Interview (ADI) criteria, gold standards of research-based autism
             diagnosis

          -  Intelligence quotient (IQ) > 70

          -  Normal or corrected-to-normal vision

        Exclusion Criteria for ASD Participants:

          -  Recent occurrence of seizures (past 5 years)

          -  Brain damage or head trauma (can be included at discretion of PI and sponsor)

          -  Color blind

          -  Cardiovascular disease

          -  Presence of a severe medical problem

          -  Severe mental retardation

          -  Alcoholism or substance abuse

          -  Asthma (can be included at the discretion of study physician/nurse practitioner if
             episodes are infrequent and no active problems at time of the study)

          -  Migraine headaches (at the discretion of the nurse practitioner or the study
             physician)

          -  Claustrophobia (at discretion of study physician/designee/PI)

          -  Pacemakers, cochlear implants, surgical clips or metal fragments

        Inclusion Criteria for Healthy Age-Matched Controls:

          -  IQ > 70

          -  Normal or corrected-to-normal vision

        Exclusion Criteria for Healthy Age-Matched Controls:

          -  History of seizures

          -  Neurological disorder

          -  Current psychiatric disorder

          -  Previous psychiatric disorder (can be included at discretion of PI)

          -  Current use of psychoactive drugs

          -  Previous use of psychoactive drugs (can be included at discretion of PI)

          -  Head trauma (can be included at discretion of PI)

          -  Alcoholism or substance abuse

          -  Cardiovascular disease

          -  Color blind

          -  Asthma (can be included at the discretion of study physician/nurse practitioner if
             episodes are infrequent and no active problems at time of the study)

          -  Migraine headaches (at the discretion of the nurse practitioner or the study
             physician)

          -  Claustrophobia (at discretion of study physician/designee/PI)

          -  Presence of a severe medical problem

          -  Severe mental retardation

          -  Pacemakers, cochlear implants, surgical clips or metal fragments