araag2/HINT huggingface dataset:
Clinical trial NCT02274766 (phase 3, status: completed)
Conditions: dyskinesia, levodopa-induced dyskinesia (lid), parkinson's disease (pd)
ICD codes: K22.4, G24.01, K22.4, G24.01, G20
Drugs: ads-5102
SMILES: NC12CC3CC(CC(C3)C1)C2
Eligibility criteria:

        Inclusion Criteria:

          -  Signed a current IRB/REB/IEC-approved informed consent form;

          -  Parkinson's disease, per UK Parkinson's Disease Society (UKPDS) Brain Bank Clinical
             Diagnostic Criteria;

          -  On a stable regimen of antiparkinson's medications for at least 30 days prior to
             screening, including a levodopa preparation administered not less than three times
             daily, and willing to continue the same doses and regimens during study participation;

          -  Following diary training, the subject is willing and able to understand and complete
             the 24-hour PD home diary (trained caregiver/study partner assistance allowed);

          -  Any other current and allowed prescription/non-prescription medications and/or
             nutritional supplements taken regularly must have been at a stable dose and regimen
             for at least 30 days prior to screening, and subject must be willing to continue the
             same doses and regimens during study participation (this criterion does not apply to
             medications that are being taken pre-study only on an as-needed basis);

        Exclusion Criteria:

          -  History of neurosurgical intervention related to Parkinson's disease (e.g. deep brain
             stimulation);

          -  History of seizures within 2 years prior to screening;

          -  History of stroke or TIA within 2 years prior to screening;

          -  History of cancer within 5 years prior to screening, with the following exceptions:
             adequately treated non-melanomatous skin cancers, localized bladder cancer,
             non-metastatic prostate cancer, in situ cervical cancer, or other definitively treated
             cancer that is considered cured;

          -  Presence of cognitive impairment, as evidenced by a Mini-Mental Status Examination
             (MMSE) score of less than 24 during screening;

          -  If female, is pregnant or lactating;

          -  If a sexually active female, is not surgically sterile or at least 2 years
             post-menopausal, or does not agree to utilize an effective method of contraception
             from screening through at least 4 weeks after the completion of study treatment, using
             one of the following: barrier methods (diaphragm or partner using condoms plus use of
             spermicidal jelly or foam, preferably double-barrier methods); oral or implanted
             hormonal contraceptive; intrauterine device (IUD); or vasectomized male partner;

          -  Treatment with an investigational drug or device within 30 days prior to screening;

          -  Treatment with an investigational biologic within 6 months prior to screening;

          -  Current participation in another clinical trial;
Clinical trial NCT02275780 (phase 3, status: active, not recruiting)
Conditions: hiv-1
ICD codes: B20, Z71.7, O98.72, Z21, O98.73, R75, Z11.4
Drugs: doravirine, darunavir, ritonavir, truvada™ or epzicom™/kivexa™
SMILES: CN1C(O)=NN=C1CN1C=CC(=C(OC2=CC(=CC(Cl)=C2)C#N)C1=O)C(F)(F)F, [H][C@@]12CCO[C@]1([H])OC[C@@H]2OC(=O)N[C@@H](CC1=CC=CC=C1)[C@H](O)CN(CC(C)C)S(=O)(=O)C1=CC=C(N)C=C1, CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)COC1=C(C)C=CC=C1C)CC1=CC=CC=C1, [H][C@@](C)(CN1C=NC2=C(N)N=CN=C12)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C
Eligibility criteria:

        Inclusion Criteria:

          -  Is HIV-1 positive and has HIV treatment indicated based on physician assessment.

          -  Has received no (0 days of) antiretroviral therapy (ART), including investigational
             antiretroviral agents.

          -  Is considered clinically stable with no signs or symptoms of active infection for at
             least 2 weeks prior to the start of treatment.

          -  Female is highly unlikely to become pregnant, or male is highly unlikely to impregnate
             a partner because they are not of reproductive potential, or agree to practice
             abstinence or use acceptable contraception for up to 14 days after the last dose of
             study drug.

          -  Eligibility for the Study Extension 1 at the Week 96 visit: 1) completed the Week 96
             visit, 2) derived benefit from participation through Week 96 in the opinion of the
             investigator, 3) is a clinically-appropriate candidate for an additional 96 weeks of
             treatment with the Study Extension regimen.

          -  Eligibility for the Study Extension 2 at the Week 192 visit: 1) completed the Week 192
             visit, 2) derived benefit from participation through Week 192 in the opinion of the
             investigator, 3) is a clinically-appropriate candidate for 96 weeks of treatment with
             the Study Extension regimen.

        Exclusion Criteria:

          -  Uses or has had a recent history of using recreational or illicit drugs.

          -  Has been treated for a viral infection other than HIV-1, such as hepatitis B, with an
             agent that is active against HIV-1.

          -  Has documented or known resistance to study drugs including doravirine, darunavir,
             ritonavir, emtricitabine, tenofovir, abacavir and/or lamivudine.

          -  Has participated in a study with an investigational compound/device within the prior
             month, or anticipates doing so during this study.

          -  Has used systemic immunosuppressive therapy or immune modulators within the prior 30
             days, or anticipates doing so during this study.

          -  Has significant hypersensitivity or other contraindication to any of the components of
             the study drugs.

          -  Has a current (active) diagnosis of acute hepatitis due to any cause.

          -  Is pregnant, breastfeeding or expecting to conceive at any time during the study.

          -  Female who expects to donate eggs, or male who expects to donate sperm at any time
             during the study.
Clinical trial NCT02277769 (phase 3, status: completed)
Conditions: dermatitis, atopic
ICD codes: L20.89, L20.9
Drugs: dupilumab, placebo (for dupilumab)
SMILES: CCO, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          1. Chronic AD that has been present for at least 3 years before the screening visit;

          2. ≥10% body surface area (BSA) of AD involvement at the screening and baseline visits;

          3. Documented recent history (within 6 months before the screening visit) of inadequate
             response to treatment with topical medications or for whom topical treatments are
             otherwise medically inadvisable (eg, because of important side effects or safety
             risks).

        Exclusion Criteria:

          1. Participation in a prior Dupilumab clinical study.

          2. Treatment with an investigational drug within 8 weeks or within 5 half-lives (if
             known), whichever is longer, before the baseline visit;

          3. Having used any of the following treatments within 4 weeks before the baseline visit,
             or any condition that, in the opinion of the investigator, is likely to require such
             treatment(s) during the first 4 weeks of study treatment:

               -  Immunosuppressive/ immunomodulating drugs (eg, systemic corticosteroids,
                  cyclosporine, mycophenolate-mofetil, IFN-γ, Janus kinase inhibitors,
                  azathioprine, methotrexate, etc.)

               -  Phototherapy for AD

          4. Regular use (more than 2 visits per week) of a tanning booth/ parlor within 4 weeks of
             the screening visit;

          5. Treatment with a live (attenuated) vaccine within 12 weeks before the baseline visit;

          6. History of human immunodeficiency virus (HIV) infection or positive HIV serology at
             screening;

          7. Positive with hepatitis B surface antigen (HBsAg) or hepatitis C antibody at the
             screening visit;

          8. Active chronic or acute infection requiring systemic treatment within 2 weeks before
             the baseline visit;

          9. Known or suspected history of immunosuppression;

         10. Pregnant or breastfeeding women, or women planning to become pregnant or breastfeed
             during the study;

         11. Women unwilling to use adequate birth control, if of reproductive potential and
             sexually active.

        Note: The information listed above is not intended to contain all considerations relevant
        to a participant's potential participation in this clinical trial therefore not all
        inclusion/ exclusion criteria are listed.
Clinical trial NCT02278120 (phase 3, status: active, not recruiting)
Conditions: advanced metastatic breast cancer
ICD codes: C79.81, D24.1, D24.2, D24.9, D49.3, C44.501, D48.60
Drugs: lee011, tamoxifen, letrozole, anastrozole, goserelin, lee011 placebo
SMILES: CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(C=N3)N3CCNCC3)N=C2N1C1CCCC1, OC1=CC=C(C=C1)C1=C(C(=O)C2=CC=C(OCCN3CCCCC3)C=C2)C2=C(S1)C=C(O)C=C2, N#CC1=CC=C(C=C1)C(N1C=NC=N1)C1=CC=C(C=C1)C#N, CC(C)(C#N)C1=CC(=CC(CN2C=NC=N2)=C1)C(C)(C)C#N, CC(C)C[C@H](NC(=O)[C@@H](CC1=CNC2=CC=CC=C12)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NCC(N)=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Patient has advanced (locoregionally recurrent or metastatic) breast cancer not
             amenable to curative therapy

          -  Patient is premenopausal or perimenopausal at the time of study entry

          -  Patients who received (neo) adjuvant therapy for breast cancer are eligible

          -  Patient has a histologically and/or cytologically confirmed diagnosis of
             estrogen-receptor positive and/or progesterone receptor positive breast cancer

          -  Patient has HER2-negative breast cancer

          -  Patient must have either measurable disease or If no measurable disease is present,
             then at least one predominantly lytic bone lesion

          -  Patient has an Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

          -  Patient has adequate bone marrow and organ function

        Exclusion Criteria:

          -  Patient who has received a prior CDK4/6 inhibitor

          -  Patient is postmenopausal

          -  Patients who currently have inflammatory breast cancer at screening.

          -  Patients who received any prior hormonal anti-cancer therapy for advanced breast
             cancer, except for ≤ 14 days of tamoxifen or NSAI ± goserelin for advanced breast
             cancer prior to randomization.

          -  Patient has a concurrent malignancy or malignancy within 3 years of randomization,
             with the exception of adequately treated basal cell skin carcinoma, squamous cell skin
             carcinoma, non-melanomatous skin cancer or curatively resected cervical cancer.

          -  Patient with CNS metastases.

          -  Patient has active cardiac disease or a history of cardiac dysfunction

          -  Patient is currently using other antineoplastic agents

          -  Patient is pregnant or nursing or physiologically capable of becoming pregnant and not
             using highly effective contraception

        Other protocol-defined Inclusion/Exclusion may apply.
Clinical trial NCT02281552 (phase 3, status: completed)
Conditions: rheumatoid arthritis
ICD codes: M06.9, M05.9, M06.08, M06.00, M06.011, M06.012, M06.019
Drugs: tofacitinib, tofacitinib
SMILES: [H][C@@]1(C)CCN(C[C@]1([H])N(C)C1=NC=NC2=C1C=CN2)C(=O)CC#N, [H][C@@]1(C)CCN(C[C@]1([H])N(C)C1=NC=NC2=C1C=CN2)C(=O)CC#N
Eligibility criteria:

        Inclusion Criteria:

          -  diagnosis of rheumatoid arthritis

          -  currently taking a stable dose of methotrexate

          -  no evidence of active or latent or inadequately treated tuberculosis

        Exclusion Criteria:

          -  evidence or history of clinically significant hematological, renal, endocrine,
             pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic or
             allergic disease

          -  clinically significant infections within the past 6 months
Clinical trial NCT02282020 (phase 3, status: active, not recruiting)
Conditions: relapsed ovarian cancer, brca mutation, platinum sensitivity
ICD codes: H53.71, H53.72, K90.41
Drugs: olaparib, single agent chemotherapy
SMILES: OC1=NN=C(CC2=CC(C(=O)N3CCN(CC3)C(=O)C3CC3)=C(F)C=C2)C2=CC=CC=C12, [H][C@@]12N(C)C3=CC(OC)=C(C=C3[C@@]11CCN3CC=C[C@](CC)([C@@]13[H])[C@@]([H])(OC(C)=O)[C@]2(O)C(=O)OC)[C@]1(C[C@@]2([H])CN(CC(CC)=C2)CC2=C1NC1=CC=CC=C21)C(=O)OC
Eligibility criteria:

        Inclusion Criteria:

          -  Patients must be ≥ 18 years of age

          -  Patients with histologically diagnosed relapsed high grade serous ovarian cancer
             (including primary peritoneal and/or fallopian tube cancer) or high grade endometrioid
             cancer. Patients are eligible to undergo BRCA testing even if they have not yet had
             recurrence or progression of disease >6 months (>/=183 days) after completion of their
             last platinum therapy.

          -  Documented germline mutation in Breast Cancer susceptibility genes: BRCA1 and/or BRCA2
             that is predicted to be deleterious or suspected deleterious (known or predicted to be
             detrimental/lead to loss of function)

          -  At least one lesion that can be accurately assessed at baseline by CT/MRI and is
             suitable for repeated assessment.

          -  Patients must have received at least 2 prior platinum based lines of chemotherapy -
             Patients must be partially platinum sensitive or platinum sensitive

          -  Patients must be suitable to start treatment with single agent chemotherapy based on
             physician's choice

          -  Patients must have normal organ and bone marrow function measured within 28 days of
             randomisation,

          -  Eastern Cooperative Oncology Group (ECOG) performance status 0-2

          -  Patients must have a life expectancy ≥ 16 weeks

          -  Formalin fixed, paraffin embedded tumour sample from the primary or recurrent cancer
             must be available for central testing.

        Exclusion Criteria:

          -  BRCA 1 and/or BRCA2 mutations that are considered to be non detrimental

          -  Exposure to any investigational product within 30 days or 5 half lives (whichever is
             longer) prior to randomisation

          -  Any previous treatment with a Polyadenosine 5'diphosphoribose polymerisation (PARP)
             inhibitor, including olaparib.

          -  Patients who have platinum resistant or refractory disease

          -  Patients receiving any systemic chemotherapy within 3 weeks prior to first dose of
             study treatment

          -  Previous single agent exposure to the selected chemotherapy regimen for randomisation.
             - Prior malignancy in the last 5 years, unless curatively treated and recurrence free
             (few exceptions apply).
Clinical trial NCT02282761 (phase 3, status: completed)
Conditions: schizophrenia
ICD codes: F20.0, F20.1, F20.2, F20.3, F20.5, F20.89, F20.9
Drugs: iti-007, placebo
SMILES: [H][C@]12CCN(CCCC(=O)C3=CC=C(F)C=C3)C[C@@]1([H])C1=CC=CC3=C1N2CCN3C, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  male or female subjects of any race, ages 18-60 inclusive, with a clinical diagnosis
             of schizophrenia

          -  experiencing an acute exacerbation of psychosis

        Exclusion Criteria:

          -  any subject unable to provide informed consent

          -  any female subject who is pregnant or breast-feeding

          -  any subject judged to be medically inappropriate for study participation
Clinical trial NCT02284516 (phase 3, status: completed)
Conditions: dry eye disease
ICD codes: H04.121, H04.122, H04.123, H04.129, H35.3111, H35.3112, H35.3121
Drugs: lifitegrast, placebo
SMILES: CS(=O)(=O)C1=CC(C[C@H](NC(=O)C2=C(Cl)C3=C(CN(CC3)C(=O)C3=CC=C4C=COC4=C3)C=C2Cl)C(O)=O)=CC=C1, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Patient-reported history of Dry Eye Disease in both eyes.

          -  Use of over the counter artificial tears within the past 30 days.

          -  A negative urine pregnancy test for females and willingness to use adequate birth
             control throughout the study.

          -  Able and willing to comply with all study procedures.

        Exclusion Criteria:

          -  Presence of an ocular condition that could affect the study parameters such as active
             ocular infections, ocular inflammation, glaucoma, or diabetic retinopathy;.

          -  Unwilling to stop wearing contact lenses during the study.

          -  LASIK or other ocular surgical procedures within 12 months prior to or during the
             study.

          -  Use of prohibited medications

          -  Significant medical conditions that could affect the study parameters.
Clinical trial NCT02284893 (phase 3, status: completed)
Conditions: type 2 diabetes
ICD codes: E11.65, E11.9, E11.21, E11.36, E11.41, E11.42, E11.44
Drugs: saxagliptin, dapagliflozin, sitagliptin, placebo matching with saxagliptin, placebo matching with dapagliflozin, placebo matching with sitagliptin
SMILES: N[C@H](C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N)C12CC3CC(CC(O)(C3)C1)C2, CN(C)C(=N)NC(N)=N, N[C@@H](CC(=O)N1CCN2C(C1)=NN=C2C(F)(F)F)CC1=CC(F)=C(F)C=C1F, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        For more information regarding BMS clinical trial participation, please visit
        www.BMSStudyConnect.com

        Inclusion Criteria:

          -  Patients with Type 2 diabetes mellitus (T2DM) with inadequate glycemic control,
             defined as a central laboratory glycosylated hemoglobin (HbA1c) ≥8.0% and ≤ 10.5 %
             obtained at the screening visit

          -  Subjects should have been taking the same daily dose of metformin ≥ 1500 mg for at
             least 8 weeks prior to the enrollment visit and with no intake of other
             antihyperglycemic therapy for more than 14 days (consecutive or not) during 12 weeks
             prior to screening

          -  BMI > 20.0 kg/m2 at the enrollment visit

          -  Males and Females, age ≥18 years old at time of screening visit

          -  Women of childbearing potential (WOCBP) must have a negative serum or urine pregnancy
             test (minimum sensitivity 25 IU/L or equivalent units of HCG) within 24 hours prior to
             the start of study drug

          -  Women must not be breastfeeding

        Exclusion Criteria:

          -  Clinically diagnosed with Type I diabetes, known diagnosis of Maturity Onset Diabetes
             of Young (MODY), secondary diabetes mellitus or diabetes insipidus

          -  History of diabetic ketoacidosis

          -  Any of the following cardiovascular (CV)/Vascular Diseases within 3 months of the
             enrollment visit

               -  Myocardial infarction

               -  Cardiac surgery or revascularization (coronary artery bypass surgery Coronary
                  Artery Bypass Graft [(CABG)]/percutaneous transluminal coronary angioplasty
                  percutaneous transluminal coronary angioplasty [(PTCA)])

               -  Unstable angina

               -  Unstable congestive heart failure (CHF)

               -  Transient ischemic attack (TIA) or significant cerebrovascular disease

               -  Unstable or previously undiagnosed arrhythmia

               -  Congestive heart failure, defined as New York Heart Association (NYHA) Class III
                  and IV, unstable or acute congestive heart failure and/or known left ventricular
                  ejection fraction of ≤ 40%

          -  Renal Disease

          -  Hepatic Diseases

          -  Hematological and Oncological Disease/Conditions

          -  Hemoglobin ≤ 11.0 g/dL (110 g/L) for men; hemoglobin ≤ 10.0 g/dL (100 g/L) for women

          -  Abnormal Free T4
Clinical trial NCT02285062 (phase 3, status: active, not recruiting)
Conditions: lymphoma, large b-cell, diffuse
ICD codes: S33.110S, S33.111S, S33.120S, S33.121S, S33.130S, S33.131S, S33.140S
Drugs: lenalidomide, placebo, rituximab, cyclophosphamide, doxorubicin, prednisone, vincristine
SMILES: NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, ClCCN(CCCl)P1(=O)NCCCO1, ClCCN(CCCl)P1(=O)NCCCO1, COC1=CC=CC2=C1C(=O)C1=C(O)C3=C(C[C@](O)(C[C@@H]3O[C@H]3C[C@H](N)[C@H](O)[C@H](C)O3)C(=O)CO)C(O)=C1C2=O, [H][C@@]12CC=C(C3=CC=CN=C3)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C, CC[C@]1(O)C[C@@H]2CN(C1)CCC1=C(NC3=CC=CC=C13)[C@@](C2)(C(=O)OC)C1=C(OC)C=C2N(C=O)[C@@H]3[C@]4(CCN5CC=C[C@](CC)([C@@H]45)[C@@H](OC(C)=O)[C@]3(O)C(=O)OC)C2=C1
Eligibility criteria:

        Inclusion Criteria:

          1. Histologically proven Diffuse Large B-Cell Lymphoma of the Activated B-Cell type

          2. Newly diagnosed, previously untreated Diffuse Large B-Cell Lymphoma

          3. Measurable Diffuse Large B-Cell Lymphoma disease by Computed Tomography (CT) /
             Magnetic Resonance Imagining (MRI) scans

          4. Eastern Cooperative Oncology Group (ECOG) performance status 0 - 2

          5. Age 18 - 80 years; age > 80 allowed at investigator discretion if performance status ≤
             1; and each organ system score ≤ 2 using cumulative illness rating scale (CIRS)

        Exclusion Criteria:

          1. Diagnosis of lymphoma histologies other than Diffuse Large B-Cell Lymphoma

          2. History of malignancies, other than Diffuse Large B-Cell Lymphoma, unless the patient
             has been disease free for 5 years or more

          3. Known seropositive for, or history of, active Human Immunodeficiency Virus (HIV)
             Hepatitis B Virus (HBV), Hepatitis C Virus (HCV)

          4. Contraindication to any drug in the chemotherapy regimen, and specifically: LVEF (Left
             Ventricular Ejection Fraction) < 45% or peripheral neuropathy grade 2
Clinical trial NCT02287584 (phase 3, status: completed)
Conditions: schizophrenia
ICD codes: F20.0, F20.1, F20.2, F20.3, F20.5, F20.89, F20.9
Drugs: dsp-5423p placebo, dsp-5423p 40mg, dsp-5423p 80mg, dsp-5423p placebo-to-flex, dsp-5423p active-to-flex
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Patients who have schizophrenia diagnosed by DSM-5, diagnostic criteria

          -  Patients who are aged 18 years or older at informed consent

          -  Patient understands the objectives and procedures of the study and who provide written
             voluntarily consent to participate in the study, etc.

        Exclusion Criteria:

          -  Patients who fall under a contraindication listed in the blonanserin (LONASEN) package
             insert

          -  Patients with Parkinson disease

          -  Patients who previously received blonanserin, etc.