araag2/HINT huggingface dataset:
Clinical trial NCT00423852 (phase 1/phase 2, status: completed)
Conditions: brain and central nervous system tumors, extragonadal germ cell tumor, ovarian cancer, teratoma, testicular germ cell tumor
ICD codes: C05.2, C10.0, C16.0, C16.4, C17.0, C17.1, C17.2, E29.0, E29.1, E29.8, E29.9, E89.5, N50.811, N50.812
Drugs: carboplatin, ifosfamide, paclitaxel
SMILES: N[C@@H](CCCNC(N)=N)C(O)=O, N[C@@H](CCCNC(N)=N)C(O)=O, [H][C@@]1(C[C@@H](C)[C@]2([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]3([H])CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](OCCO)[C@@H](C1)OC
Eligibility criteria:

        DISEASE CHARACTERISTICS:

          -  Histologically confirmed germ cell tumor (GCT)

               -  Primary CNS GCT allowed

          -  Unidimensionally measurable disease OR elevated serum tumor markers (alpha-fetoprotein
             and/or human chorionic gonadotropin)

          -  Advanced disease

               -  Disease resistant to a cisplatin-based chemotherapy regimen (i.e., failed to
                  achieve a durable complete response to cisplatin)

          -  Known residual disease after post-chemotherapy surgery allowed

        PATIENT CHARACTERISTICS:

          -  Platelet count ≥ 100,000/mm^3

          -  WBC ≥ 3,000/mm^3

          -  Creatinine clearance > 50 mL/min (unless due to tumor obstructing the ureters)

          -  AST and ALT < 2 times upper limit of normal (ULN)

          -  Bilirubin < 1.5 times ULN

          -  Not pregnant or nursing

          -  Negative pregnancy test

          -  Fertile patients must use effective contraception

          -  No active infection

          -  Negative serology for HIV type I and II, human T-lymphotropic virus type I and II,
             hepatitis B or C virus, syphilis, and cytomegalovirus

               -  Hepatitis C negative serology by RIBA or PCR

          -  Adequate medical condition for general anesthesia

        PRIOR CONCURRENT THERAPY:

          -  See Disease Characteristics

          -  Recovered from recent surgery

          -  At least 3 weeks since prior chemotherapy

          -  No prior high-dose therapy with autologous bone marrow transplantation

          -  No other concurrent chemotherapy

          -  No other concurrent treatment (e.g., surgery or radiotherapy)
Clinical trial NCT01314885 (phase 1, status: completed)
Conditions: chronic obstructive pulmonary disease (copd)
ICD codes: G91.1, I42.1, N11.1, J05.0, G47.33, J44.9, N13.8
Drugs: pf-03715455, ph-797804, placebo for pf-03715455, placebo for ph-797804
SMILES: CC(C)(C)C1=NN(C(NC(O)=NCC2=CC=CC=C2SC2=CN3C(C=C2)=NN=C3C2=CC=CC=C2SCCO)=C1)C1=CC(Cl)=C(O)C=C1, CNC(=O)C1=CC=C(C)C(=C1)N1C(C)=CC(OCC2=C(F)C=C(F)C=C2)=C(Br)C1=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Male or female (of non-child bearing potential) subjects, aged 18-50 years.

          -  Subjects whose FEV1 and FVC at screening are both greater than or equal to 80% of
             their predicted value for age, race, sex and height.

          -  Subjects who have normoresponsive airways.

          -  Subjects who are able to successfully complete screening sputum inductions.

        Exclusion Criteria:

          -  Subjects who have evidence, on review of pre-study laboratory data and full physical
             examination, or history of any clinically significant hematological, renal, endocrine,
             gastrointestinal, dermatological, hepatic, psychiatric, neurologic diseases.
             Specifically liver function tests and CRP must be within the reference range.

          -  Subjects with a medical history of asthma symptomatology (ie, wheeze and/or dyspnea at
             rest).

          -  Subjects who have experienced a respiratory tract infection within the previous 4
             weeks or any other infection within 1 week of dosing
Clinical trial NCT01606397 (phase 1, status: completed)
Conditions: diabetes mellitus, type 2
ICD codes: E11.65, E11.9, E11.21, E11.36, E11.41, E11.42, E11.44
Drugs: placebo, ly2409021
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, CC1=CC(O[C@@H](CCC(F)(F)F)C2=CC=C(C=C2)C(=O)NCCC(O)=O)=CC(C)=C1C1=CC=C(C=C1)C(C)(C)C
Eligibility criteria:

        Inclusion Criteria:

          -  Must be either a male, or a female who cannot become pregnant, who has type 2 diabetes
             and is either controlling diabetes through diet and exercise, or taking metformin

          -  Have an hemoglobin A1c (HbA1c) value at screening of greater than or equal to 6.5% and
             less than or equal to 10.0% on a stable treatment regimen at the time of measurement

          -  Have a screening body mass index (BMI) of 20 to 40 kg/m^2 inclusive

          -  Have a blood pressure reading at screening of between 90 to 160 millimeters of mercury
             (mmHg) (systolic) and 40 to 95 mmHg (diastolic)

        Exclusion Criteria:

          -  Have used insulin for diabetic control within 1 year of study entry

          -  Have used thiazolidinediones within 3 months, or any other drugs for treatment of
             hyperglycemia (except metformin) within 1 month, prior to first planned dosing.
             Metformin is acceptable for this study.

          -  Have clinically significant coronary artery disease

          -  Have clinically significant peripheral vascular disease

          -  Have clinical evidence of active diabetic proliferative retinopathy

          -  Have known significant autonomic neuropathy as evidenced by urinary retention,
             orthostatic hypotension, diabetic diarrhea or gastroparesis

          -  Impaired renal function (serum creatinine greater than 115 micromoles/liter [μmol/L]
             [1.3 mg/dL] in women, greater than 130 μmol/L [1.5 mg/dL] in men)

          -  Have triglycerides greater than 4.5 millimoles per liter (mmol/L) [approximately 400
             mg/dL] at screening

          -  Were hospitalized for poor control of diabetes (keto-acidotic episode) in the last 6
             months

          -  Are allergic to LY2409021 or similar drugs

          -  Have history or presence of cardiovascular, respiratory, hepatic, renal,
             gastrointestinal, endocrine (other than diabetes), hematological, or neurological
             disorders capable of significantly altering the absorption, or metabolism or
             elimination of drugs or of constituting a risk when taking the study medication or
             interfering with the interpretation of data

          -  Have used systemic glucocorticoids within 1 month prior to first dosing

          -  Have donated 450 mL or more of blood in the last 3 months or have donated any blood
             within the last month

          -  Have a regular alcohol intake greater than 21 units/week (male), or 14 units/week
             (female), or are unwilling to stop alcohol as required by the study restrictions (1
             unit = 360 mL of beer, or 150 mL of wine, or 45 mL of spirits)
Clinical trial NCT00647972 (phase 1, status: terminated)
Conditions: healthy
ICD codes: Z76.3, Z76.2
Drugs: olanzapine tablets 20 mg, zyprexa® tablets 20 mg
SMILES: CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2, CN1CCN(CC1)C1=NC2=CC=CC=C2NC2=C1C=C(C)S2
Reason stopped: 
    during period 1 due to numerous orthostatic aes that occurred. subsequently, rld was reduced to
    5 mg due to safety concerns.
  
Eligibility criteria:

        Inclusion Criteria:

          -  healthy, adult subjects, 18 years and older

          -  able to swallow medication

        Exclusion Criteria:

          -  institutionalized subjects

          -  history of any significant disease

          -  use of any prescription or OTC medications within 14 days of start of study

          -  received any investigational products within 30 days prior to start of study
Clinical trial NCT03070730 (phase 1/phase 2, status: terminated)
Conditions: postural orthostatic tachycardia syndrome, orthostatic intolerance
ICD codes: I95.1, R80.2, R51.0
Drugs: droxidopa, atenolol, placebos
SMILES: N[C@@H]([C@H](O)C1=CC(O)=C(O)C=C1)C(O)=O, CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1, COCCC1=CC=C(OCC(O)CNC(C)C)C=C1
Reason stopped: 
    recruitment was slow and subjects declined participation after signing the icf.
  
Eligibility criteria:

        Inclusion Criteria:

          -  CDC criteria for chronic fatigue syndrome

          -  Evidence of postural tachycardia syndrome with symptoms of orthostatic intolerance

        Exclusion Criteria:

          -  Pregnant or lactating females. The administration of droxidopa is harmful to the fetus

          -  Concomitant therapy with anticholinergic, alpha-, and beta-adrenergic antagonists or
             other medications that affect autonomic function

          -  Clinically significant coronary artery, cerebrovascular or peripheral vascular disease

          -  Cardiac arrhythmias

          -  Systemic illness that might affect autonomic function such as congestive heart
             failure, hypertension, renal, pulmonary, and hepatic disease, anemia, malignancies,
             thyroid disease, and alcoholism

          -  Severe depression, severe anxiety disorder (score of on the Beck Depression Inventory
             > 29 or score on the Beck Anxiety Inventory of ≥ 36) or psychosis

          -  Antidepressant treatment by MAO inhibitors within 2 weeks before the study

          -  Glaucoma

          -  Liver disease

          -  Subjects with a history of reaction to local anesthetic will be excluded from the
             study

          -  Subjects who have a history of any bleeding disorders or significantly impaired wound
             healing will be excluded. Subjects who are using any medications such as Coumadin or
             Plavix will be also excluded

          -  Subjects who are currently enrolled in any other studies using investigational
             products
Clinical trial NCT01555008 (phase 1, status: completed)
Conditions: type 2 diabetes mellitus, renal impairment
ICD codes: E11.65, E11.9, E11.21, E11.36, E11.41, E11.42, E11.44, M10.38, M10.30, M10.311, M10.312, M10.319, M10.321, M10.322
Drugs: lx4211, lx4211 placebo
SMILES: CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Adults ≥18 to ≤80 years of age

          -  History of T2DM for at least 6 months prior to screening

          -  Moderate to severe renal impairment and not actively on dialysis

          -  Willing and able to perform self-monitoring of blood glucose

          -  Willing and able to provide written informed consent

        Exclusion Criteria:

          -  History of type 1 diabetes mellitus, diabetic ketoacidosis (within the previous 6
             months), or diabetes resulting from pancreatic disorder or secondary diabetes (from
             acromegaly and/or Cushing's disease)

          -  Subjects who have received a renal allograft

          -  Subjects expecting to require dialysis or to undergo kidney transplantation within 3
             months of study dosing

          -  Presence of active hepatic disease or clinically significant abnormal liver function
             tests at Screening or planned study Day -1

          -  Subjects with a history of heart attack, severe/unstable angina, or coronary
             revascularization procedure within 6 months prior to study Day -2

          -  History of clinically significant cardiac arrhythmias within 1 year prior to study Day
             -2

          -  Subjects with congestive heart failure

          -  Subjects with uncontrolled Stage III hypertension

          -  History of 2 or more emergency room visits, doctors' visits, or hospitalizations due
             to hypoglycemia within the 6 months prior to planned study Day -2

          -  History of alcohol or illicit drug abuse within 1 year prior to Screening

          -  History of human immunodeficiency virus (HIV), hepatitis B, or hepatitis C

          -  Major surgery within 6 months prior to planned study Day -2

          -  History of any malignancy within the last 5 years

          -  Triglycerides >1000 mg/dL at Screening or planned study Day -1

          -  History of any serious adverse reaction or hypersensitivity to an SGLT inhibitor

          -  Use of corticosteroids within 2 weeks prior to study Day 1

          -  Use of any investigational drug within 30 days prior to study Day 1, or
             investigational protein or antibodies within 60 days of Day 1

          -  Positive urine pregnancy test at Screening

          -  Positive urine screen for illicit drug abuse at Screening

          -  Prior exposure to LX4211
Clinical trial NCT01469065 (phase 1, status: completed)
Conditions: diabetes mellitus, type 2
ICD codes: E11.65, E11.9, E11.21, E11.36, E11.41, E11.42, E11.44
Drugs: pf-04991532, pf-04991532, pf-04991532, pf-0499132, placebo
SMILES: [H][C@@](CC1CCCC1)(N1C=NC(=C1)C(F)(F)F)C(O)=NC1=NC=C(C=C1)C(O)=O, [H][C@@](CC1CCCC1)(N1C=NC(=C1)C(F)(F)F)C(O)=NC1=NC=C(C=C1)C(O)=O, [H][C@@](CC1CCCC1)(N1C=NC(=C1)C(F)(F)F)C(O)=NC1=NC=C(C=C1)C(O)=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Patients with type 2 diabetes mellitus who are taking either no medication for the
             treatment of diabetes (diet/exercise therapy only), or who are taking only a single
             oral anti-diabetic drug (OAD) that can be temporarily discontinued for approximately
             8-10 weeks. For those taking a single OAD, treatment should be stable, where this is
             defined as no change in the treatment, including dose, over the past 3 months prior to
             Screening. OAD medications that are acceptable to be discontinued include: a
             sulfonylurea (SU), a meglitinide, a biguanide (eg, metformin), a dipeptidyl peptidase
             4 inhibitor (DPP-4i), or an alpha glucosidase inhibitor.

          -  Body Mass Index (BMI) of 18.5 to 45.0 kg/m2; and a total body weight >50 kg (110 lbs).

          -  HbA1c >/=7% and </=10% if the patient is on diet/exercise therapy only and does not
             require any OAD discontinuation. HbA1c >/=6.5% and </=9% if the patient requires to be
             washed off an OAD.

        Exclusion Criteria:

          -  Evidence or history of diabetic complications with significant end organ damage.

          -  History of stroke or transient ischemic attack.

          -  History of myocardial infarction.

          -  History of coronary artery bypass graft or stent implantation.

          -  Clinically significant peripheral vascular disease.

          -  Any history or clinical evidence of congestive heart failure, NYHA Classes II IV.

          -  Current history of angina/unstable angina.

          -  One or more episodes of hypoglycemia within the last 3 months, or two or more episodes
             of hypoglycemia within the last 6 months.

          -  A positive urine drug screen.

          -  Use of tobacco or nicotine-containing products in excess of the equivalent of 10
             cigarettes per day.

          -  Blood pressure >/=160 mm Hg (systolic) or >/=100 mm Hg (diastolic), following at least
             5 minutes of rest.

          -  Pregnant or nursing females; females of childbearing potential.
Clinical trial NCT01431898 (phase 1, status: completed)
Conditions: hepatitis c
ICD codes: B18.2, B17.10, B17.11, B19.20, B19.21, B15.0, B15.9
Drugs: gs-9669 tablets, placebo to match gs-9669 tablet
SMILES: CC1=CC[C@@H](CC1)C(=O)N([C@H]1CC[C@](O)(CO[C@H]2CCOC2)CC1)C1=C(SC(=C1)C#CC(C)(C)C)C(O)=O, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          -  Adult subjects 18-65 years of old, inclusive

          -  Documented chronic HCV infection to be of at least 6 months duration and plasma HCV
             RNA ≥ 5 log10 IU/mL at screening.

          -  HCV treatment naïve or PEG-IFN, IFN, and/or RBV experienced (treatment must have
             ceased at least 3 months prior to screening). Treatment experienced subjects should
             not exceed 40% of the subjects enrolled in each cohort

          -  Mono-infection with HCV genotype 1a for Cohorts 1, 2, 3, 4, and 5 and mono-infection
             with HCV genotype 1b for Cohort 6 and 7.

          -  Estimated creatinine clearance ≥ 70 mL/min,

          -  QTcF interval ≤ 450 msec for males and ≤ 470 msec for females, QRS duration < 120
             msec, PR interval < 220 msec,

          -  Body mass index (BMI) of 19.0 to 34.0 kg/m^2, inclusive.

        Exclusion Criteria:

          -  Urine drug screen positive for illicit/illegal drugs

          -  ALT and AST levels > 5 times the upper limit of the normal range (ULN)

          -  Direct bilirubin > ULN, clinical or other laboratory evidence of hepatic
             decompensation (i.e., platelets < 90,000/mm^3, prothrombin time ≥ 1.5 × ULN and
             albumin < 3.5 g/dL) are not eligible for study participation.

          -  Subjects with an absolute neutrophil count (ANC) < 1,000 cells/mm^3 (< 750 cells/mm^3
             for black or African-American subjects), hemoglobin (Hb) < 11 g/dL,

          -  Coinfected with hepatitis B virus (HBV), human immunodeficiency virus (HIV), or
             another HCV genotype other than genotype 1a/b are not eligible for study
             participation.

          -  Evidence of hepatocellular carcinoma (e.g., a-fetoprotein > 50 ng/mL or as indicated
             by recent ultrasound or other standard of care measure)

          -  History of significant cardiac disease. The following ECG abnormalities at screening
             are exclusionary: QTcF (QT corrected using Fridericia's formula=QT/RR^0.333) > 450
             msec for males and > 470 for females; QRS > 120 msec (left or right hemiblock is not
             exclusionary); PR interval > 220 msec; bradycardia (< 45 beats per minute); second or
             third degree heart block.

          -  History of clinically-significant illness or any other major medical disorder that may
             interfere with subject treatment, assessment or compliance with the protocol

          -  History of a primary gastrointestinal disorder that could interfere with the
             absorption of the study drug or that could interfere with normal gastrointestinal
             anatomy or motility
Clinical trial NCT01640834 (phase 1, status: completed)
Conditions: diabetes mellitus, type 1
ICD codes: E10.65, E10.9, E10.21, E10.36, E10.41, E10.42, E10.44
Drugs: ly2409021, placebo, glucagon
SMILES: CC1=CC(O[C@@H](CCC(F)(F)F)C2=CC=C(C=C2)C(=O)NCCC(O)=O)=CC(C)=C1C1=CC=C(C=C1)C(C)(C)C, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O, N[C@@H](CCCNC(N)=N)C(O)=O
Eligibility criteria:

        Inclusion Criteria:

          -  Have had type 1 diabetes mellitus (T1DM) based on the World Health Organization
             classification for at least 1 year and have a daily insulin dose ≤1.5 international
             units (IU) per kilogram (kg) of body weight

          -  Have a glycated hemoglobin A1c (HbA1c) of no greater than 9.0% as measured at
             screening

          -  Have a body mass index (BMI) ≥19.0 and ≤35.0 kilograms per meter squared (kg/m^2)

          -  Have given written informed consent approved by Lilly

        Exclusion Criteria:

          -  Received any oral or injectable medication intended for the treatment of diabetes
             mellitus other than insulins in the 3 months prior to screening

          -  Have had more than 1 episode of severe hypoglycemia within 3 months prior to entry
             into the study, or are currently diagnosed as having hypoglycemia unawareness

          -  Are pregnant or intend to become pregnant during the course of the study

          -  Women who are breastfeeding

          -  Have a history of stroke, myocardial infarction, heart failure, unstable angina, or a
             coronary revascularization procedure within 6 months of screening

          -  Have fasting triglycerides >500 milligrams per deciliter (mg/dL) (5.65 millimoles per
             liter [mmol/L])

          -  Have obvious clinical signs, symptoms, or laboratory evidence of liver disease
             (alanine transaminase [ALT] or aspartate transaminase [AST] greater than 2 times the
             upper limit of normal at screening)

          -  Have a history of renal transplantation or are currently receiving renal dialysis or
             have a screening creatinine >2.0 mg/dL (177 micromoles per liter [μmol/L])

          -  Have had any other disease, illness, or condition (including known diabetic autonomic
             neuropathy, drug or alcohol abuse, or psychiatric disorder) within the 6 months prior
             to screening that precludes the participant from following and completing the study or
             could increase their risk for hypoglycemia, according to the investigator's judgment

          -  Are currently enrolled in, have completed, or have discontinued within the last 30
             days from a clinical trial involving an off-label use of an investigational drug or
             device, or are concurrently enrolled in any other type of medical research judged not
             to be scientifically or medically compatible with this study
Clinical trial NCT00254293 (phase 1/phase 2, status: completed)
Conditions: rheumatoid arthritis
ICD codes: M06.9, M05.9, M06.08, M06.00, M06.011, M06.012, M06.019
Drugs: abatacept or placebo (both as iv & sc solution), abatacept or placebo (both as iv & sc solution), abatacept or placebo (both as iv & sc solution), abatacept or placebo (both as iv & sc solution), abatacept or placebo (both as iv & sc solution), abatacept
SMILES: [H][C@@]12CCCN1C(=O)[C@H](CC1=CC=CC=C1)N1C(=O)[C@](C)(NC(=O)[C@H]3CN(C)[C@]4([H])CC5=CNC6=CC=CC(=C56)[C@@]4([H])C3)O[C@@]21O, [H][C@@]12CCCN1C(=O)[C@H](CC1=CC=CC=C1)N1C(=O)[C@](C)(NC(=O)[C@H]3CN(C)[C@]4([H])CC5=CNC6=CC=CC(=C56)[C@@]4([H])C3)O[C@@]21O, [H][C@@]12CCCN1C(=O)[C@H](CC1=CC=CC=C1)N1C(=O)[C@](C)(NC(=O)[C@H]3CN(C)[C@]4([H])CC5=CNC6=CC=CC(=C56)[C@@]4([H])C3)O[C@@]21O, [H][C@@]12CCCN1C(=O)[C@H](CC1=CC=CC=C1)N1C(=O)[C@](C)(NC(=O)[C@H]3CN(C)[C@]4([H])CC5=CNC6=CC=CC(=C56)[C@@]4([H])C3)O[C@@]21O, [H][C@@]12CCCN1C(=O)[C@H](CC1=CC=CC=C1)N1C(=O)[C@](C)(NC(=O)[C@H]3CN(C)[C@]4([H])CC5=CNC6=CC=CC(=C56)[C@@]4([H])C3)O[C@@]21O, [H][C@@]12CCCN1C(=O)[C@H](CC1=CC=CC=C1)N1C(=O)[C@](C)(NC(=O)[C@H]3CN(C)[C@]4([H])CC5=CNC6=CC=CC(=C56)[C@@]4([H])C3)O[C@@]21O
Eligibility criteria:

        Inclusion Criteria:

          -  Meet ARA criteria for diagnosis of RA with active disease.

          -  RA diagnosis for at least 1 year.

          -  > = 6 swollen joints.

          -  > = 8 tender joints.

          -  Taking methotrexate (MTX) or MTX plus not more than 1 added oral DMARD for > = 3
             months and stable for 28 days prior to dosing.

        Exclusion Criteria:

          -  Serious acute or bacterial infection in last 3 months.

          -  Chronic or recurrent bacterial infections.

          -  History of TB within previous 3 years or old TB not adequately treated.

          -  Specific lab test abnormalities

          -  History of cancer within 5 years.

          -  Exposure to CTLA4Ig (Cytotoxic T-lymphocyte (T-cell)-associated antigen 4Ig),
             belatacept, rituximab, efalizumab, alefacept, or other investigational drug or
             biologic.

          -  Treatment with hydroxychloroquine, azathioprine, leflunomide, immunoadsorption
             columns, mycophenolate mofetil, cyclosporine, D-Penicillamine or calcineurin
             inhibitors.

          -  Exposure to live vaccines.