Clinical trial NCT00801931 (phase 1/phase 2, status: terminated)
Conditions: leukemia, lymphoma, neuroblastoma, immunodeficiencies, anemia
ICD codes: C95.91, C95.92, Z80.6, Z85.6, C90.11, C90.12, C91.01, S33.110S, S33.111S, S33.120S, S33.121S, S33.130S, S33.131S, S33.140S, D84.89, D81.89, D83.8, D80.8, D53.2, D64.9, D46.4, D53.0, D53.9, D61.3, D61.9
Drugs: alemtuzumab, melphalan, busulfan, phenytoin, fludarabine, cyclophosphamide, horse antithymocyte globulin, rabbit antithymocyte globulin, thiotepa
SMILES: N[C@@H](CCCNC(N)=N)C(O)=O, N[C@@H](CC1=CC=C(C=C1)N(CCCl)CCCl)C(O)=O, CS(=O)(=O)OCCCCOS(C)(=O)=O, OC(=O)C1=CC=CC=C1O, ClCCN(CCCl)P1(=O)NCCCO1, ClCCN(CCCl)P1(=O)NCCCO1, CN(C)CCOC(C)(C1=CC=CC=C1)C1=CC=CC=N1
Reason stopped: 
    poor accrual
  
Eligibility criteria:

        Inclusion Criteria:

          -  Patients will be eligible for double cord blood stem cell transplant (TNC ≥ 4x107/kg
             of two combined units) if available single cord blood has TNC ≤4.0 x 107/kg and they
             lack a matched (5-6/6) family donor, a 10/10 unrelated adult donor, and/or if their
             disease status required emergent stem cell transplant and they could not wait 2-3
             months for searching for a matched unrelated adult donor.

          -  Adequate renal function defined as:Serum creatinine <1.5 x normal, or Creatinine
             clearance or radioisotope glomerular filtration rate (GFR) >60 ml/min/m2 or >60
             ml/min/1.73 m2 or an equivalent GFR as determined by the institutional normal range.

          -  Adequate liver function defined as:Total bilirubin <1.5 x normal, or serum
             glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase (AST)) or serum
             glutamic pyruvic transaminase (SGPT) (alanine aminotransferase (ALT)) <3.0 x normal

          -  Adequate cardiac function defined as:Shortening fraction >27% by echocardiogram, or
             Ejection fraction >47% by radionucleotide angiogram or echocardiogram.

          -  Adequate pulmonary function defined as:Uncorrected diffusing capacity of the lungs for
             carbon monoxide (DLCO) 50% by pulmonary function test.For children who are
             uncooperative, no evidence of dyspnea at rest, no exercise intolerance, and a pulse
             oximetry >94% on room air.

        Eligibility for Moderate Intensity, Reduced Intensity Regimen and Fanconi's Anemia
        (Regimens C, D and E)

          -  Adequate renal function defined as: Serum creatinine <2.0 x normal, or Creatinine
             clearance or radioisotope GFR 40 ml/min/m2 or >40 ml/min/1.73 m2 or an equivalent GFR
             as determined by the institutional normal range.

          -  Adequate liver function defined as:Total bilirubin <2.5 x normal, or SGOT (AST) or
             SGPT (ALT) <5.0 x normal

          -  Adequate cardiac function defined as:Shortening fraction of >25% by echocardiogram, or
             Ejection fraction >40% by radionucleotide angiogram or echocardiogram.

          -  Adequate pulmonary function defined as:Uncorrected DLCO >35% by pulmonary function
             test. For children who are uncooperative, no evidence of dyspnea at rest, no exercise
             intolerance, and a pulse oximetry >94% on room air.

        Exclusion Criteria:

          -  Females who are pregnant or breast-feeding

          -  Patients with documented uncontrolled infection at the time of study entry