Clinical trial NCT00716456 (phase 1/phase 2, status: completed)
Conditions: lung adenocarcinoma
ICD codes: D02.20, D02.21, D02.22
Drugs: erlotinib with cetuximab
SMILES: COCCOC1=CC2=C(C=C1OCCOC)C(NC1=CC(=CC=C1)C#C)=NC=N2
Eligibility criteria:

        Inclusion Criteria:

          -  Pathologic evidence of lung adenocarcinoma confirmed at MSKCC

          -  Measurable (RECIST) indicator lesions not previously irradiated

          -  Radiographic progression by RECIST during treatment with erlotinib

          -  Received treatment with erlotinib throughout the one month prior to enrollment

          -  Received treatment with erlotinib for >3 months

          -  At least one of the following:

          -  Previously received treatment with erlotinib, gefitinib, or an investigational EGFR TK
             inhibitor (patients may have received other treatments subsequently including
             radiation or chemotherapy) and had a radiographic partial or complete response to
             treatment as defined by RECIST criteria

          -  A documented mutation in EGFR exons 19 or 21.

          -  Karnofsky performance status ≥ or = to 70%

          -  Total bilirubin: within normal institutional limits. AST/(SGOT)/ALT(SGPT)< or = to 2.5
             X institutional upper limit of normal (ULN)

          -  Signed informed consent

          -  Effective contraception *

          -  Age > 18 years old *Sexually active women of childbearing potential must use an
             effective method of birth control during the course of the study, in a manner such
             that risk of failure is minimized. Prior to study enrollment, women of childbearing
             potential (WOCBP) must be advised of the importance of avoiding pregnancy during trial
             participation and the potential risk factors for an unintentional pregnancy. In
             addition, men enrolled on this study should understand the risks to any sexual partner
             of childbearing potential and should practice an effective method of birth control.
             All WOCBP MUST have a negative pregnancy test within two weeks prior to first
             receiving investigational product. If the pregnancy test is positive, the patient must
             not receive investigational product and must not be enrolled in the study. In
             addition, all WOCBP should be instructed to contact the Investigator immediately if
             they suspect they might be pregnant (e.g., missed or late menstrual period) at any
             time during study participation. The Investigator must immediately notify BMS in the
             event of a confirmed pregnancy in a patient participating in the study.

        Exclusion Criteria:

          -  CNS lesions which are symptomatic and/or requiring escalating doses of
             corticosteroids.

          -  Uncontrolled intercurrent illness including, but not limited to, ongoing or active
             infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
             arrhythmia, or psychiatric illness/social situations that would limit compliance with
             study requirements.

          -  Prior cetuximab or panitumumab. Prior severe infusion reaction to a monoclonal
             antibody.

          -  Current grade 2 or greater skin toxicity on erlotinib therapy

          -  Radiotherapy ≤ or = to 14 days prior to enrollment

          -  Any investigational agent or therapy ≤ or = to 30 days before enrollment

          -  Systemic chemotherapy, hormonal therapy, immunotherapy, or experimental or approved
             proteins/antibodies (except erlotinib) ≤ or = to 30 days before enrollment

          -  Women who are pregnant or lactating.

          -  Known positive test(s) for human immunodeficiency virus infection, hepatitis C virus,
             acute or chronic active hepatitis B infection

          -  Major surgery within 28 days or minor surgery within 14 days of study enrollment

          -  Men or women of child-bearing potential (women who are post-menopausal < 52 weeks, not
             surgically sterilized, or not abstinent) not consenting to use adequate contraception
             (per institutional standard of care) during the course of the study and after the last
             investigational product(s) administration (24 weeks for women, 4 weeks for men)