Clinical trial NCT02890511 (phase 1/phase 2, status: completed)
Conditions: solid tumor, stage iv gastric cancer
ICD codes: C05.2, C10.0, C16.0, C16.4, C17.0, C17.1, C17.2
Drugs: paclitaxel
SMILES: [H][C@@]1(C[C@@H](C)[C@]2([H])CC(=O)[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@]3([H])CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O2)OC)CC[C@@H](OCCO)[C@@H](C1)OC
Eligibility criteria:

        Inclusion Criteria:

          1. Patients between 18 and 70 years old

          2. Patients prognosed with advanced or metastatic solid cancer by histopathology or
             cytology analysis who have no available standard therapy or who have failed at least
             once with the standard therapy

          3. Adequate bone marrow function, liver function and adequate kidney function

          4. Eastern Cooperative Oncology Group performance status ≤ 2

          5. Life expectancy of 3 month or more

          6. Written informed consent

        Exclusion Criteria:

          1. Major infectious or neurological disease and bowel obstruction

          2. Brain metastasis or hematologic malignancy

          3. Patients who underwent surgery, radiation therapy, hormone or chemotherapy within 4
             weeks prior to the beginning of investigational drug administration

          4. Patients with the history of failure to the taxane line of chemotherapy (with the
             exception of when it was used before 6 month as adjuvant therapy or when the treatment
             was discontinued due to docetaxel related side effect)

          5. Patients who are required to continuously take P-gp (P-glycoprotein) suppressor,
             immune suppressor, proton-pump inhibitor or H2-receptor antagonist during clinical
             trial period

          6. Patients deemed by the investigator to suffer from severe heart disease (myocardial
             infarction, congestive heart failure, arrythmia accompanying drastic changes on ECG,
             severe or unstable angina pectoris, or other severe heart disease) or accompanying
             other severe internal diseases (such as uncontrollable diabetes, chronic obstructive
             pulmonary disease)

          7. Patients with prior history of participating in a clinical trial within 30 days from
             registration for current clinical trial

          8. Patient with history of alcohol or drug abuse in the recent 3 months

          9. Pregnant women, nursing mothers, or patients of childbearing age who did not agree to
             contraception (both men and women)

         10. Patients with (or suspected to have) abnormality in bile acid secretion (e.g.,.
             patients with resected gallbladder)

         11. Patients who had a history of serious gastrointestinal bleeding, or with diseases that
             could affect the absorption of oral medication (malabsorption syndrome, active peptic
             ulcer)

         12. Patients with history of severe hypersensitive reaction to active ingredient and
             excipient of the investigational drug

         13. Patient who are in a state that is deemed inappropriate to participate in the clinical
             trial by the investigator