Clinical trial NCT00165633 (phase 2/phase 3, status: terminated)
Conditions: hepatocellular carcinoma
ICD codes: C22.0, C4A.9, C7B.1, C4A.0, C4A.31, C4A.51, C4A.8
Drugs: menatetrenone, menatetrenone, placebo
SMILES: [H]\C(CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC1=C(C)C(=O)C2=CC=CC=C2C1=O)=C(\C)CCC=C(C)C, [H]\C(CC\C(C)=C(/[H])CC\C(C)=C(/[H])CC1=C(C)C(=O)C2=CC=CC=C2C1=O)=C(\C)CCC=C(C)C, CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(CC2=C(C=CC=C2)C#N)C1=O
Eligibility criteria:

        Inclusion Criteria:

          1. 20 years or older at the time of obtaining consent.

          2. Systemic conditions are 0 to 2 score of Performance Status (according to Eastern
             Cooperative Oncology Group: ECOG).

          3. Diagnosis of hepatocellular carcinoma is based on the following 1) or 2).

               -  1) Patients who are confirmed to have early tumor stain and typical finding(s) of
                  hepatocellular carcinoma with CT or MRI imaging

               -  2) Patients who underwent tumor biopsy and are histopathologically diagnosed as
                  hepatocellular carcinoma

          4. Primary onset or recurrence of hepatocellular carcinoma is not more than 1 time.

          5. Patients who underwent the following 1) or 2) within 90 days prior to registration to
             determine therapeutic effect.

               -  1) Patients who underwent local therapy to achieve complete hepatonecrosis and
                  are confirmed to have complete hepatonecrosis with CT imaging or MRI.

               -  2) Patients who underwent surgical treatment(s) and are confirmed not to have
                  residual tumor with CT or MRI imaging.

          6. Patients who meet the following items to determine liver function:

               -  1) Albumin is 2.8 g/dL or above

               -  2) Total bilirubin is under 2.0 mg/dL

               -  3) Prothrombin activation is 40% or above

          7. Patients who are given full explanation of study participation (including cancer
             notification) and submit written consent forms with their understanding as well as
             voluntary will for this study.

        Exclusion Criteria:

          1. Hepatocellular carcinoma:

               -  1) Patients who have extrahepatic metastasis

               -  2) Patients who have portal invasion

               -  3) Patients who experienced with systemic administration of anti-malignant tumor
                  drugs to treat hepatocellular carcinoma

               -  4) Patients treated with transcatheter arterial chemoembolization (TAE) alone as
                  a non-local therapy for hepatocellular carcinoma

          2. Hepatitis:

             -- 1) Patients of (a) or (b) previously treated with interferon preparations
             (including clinical studies).

               -  (a) Patients with chronic hepatitis C virus (HCV) showing HCV-RNA negative

               -  (b) Patients with viral hepatitis treated with interferon preparations within the
                  last 2 years (from the same day, 6 months earlier to the day of obtaining consent
                  forms)

               -  (c) Patients with encephalopathy in which pharmacotherapy is ineffective

               -  (d) Patients with ascites or pleural effusion that cannot be managed with
                  diuretics

          3. Systemic conditions:

               -  1) Patients unable to receive oral administration

               -  2) Patients with a history of gastrectomy or extensive resection of digestive
                  tract

               -  3) Patients who are suspected to have biliary occlusion, choleretic disorder,
                  cholecystectomy, or malabsorption of liposoluble agents

               -  4) Patients with complicated serious diseases such as cardiovascular (e.g.,
                  myocardial infarction), hematological (e.g., aplastic anemia), and/or renal
                  dysfunctions (e.g., acute and chronic renal failure)

               -  5) Patients with multiple cancers (within a 5-year cancer-free period [from the
                  same day of 5 years earlier to the day of obtaining consent forms])

          4. Drug administration:

               -  1) Patients on warfarin potassium therapy

               -  2) Patients with a known history of drug allergy to E0167 or its ingredients

               -  3) Patients who received vitamin K preparations within the recent 6 months (from
                  the same day of 6 month earlier to the day of obtaining consent forms)

          5. Other exclusion criteria

               -  1) Women of pregnant, lactating, childbearing potential, or with the intention of
                  becoming pregnant

               -  2) Patients who are presently participating in another clinical study (except for
                  follow-up surveys for study outcomes)

               -  3) Patients who are judged to be ineligible for study entry by the investigator
                  or subinvestigator