TITLE: Effects of gelatin sponge combined with moist wound-healing nursing intervention in the treatment of phase III bedsore

  ABSTRACT:
Pressure sore pertains to tissue damage or necrosis that occurs due to lack of adequate nutrition following long-term exposure to pressure and decreased blood circulation. The aim of the study was to examine the effects of gelatin sponge combined with moist wound-healing nursing intervention in the treatment of phase III bedsore. In total, 50 patients with phase III bedsore were included in the present study. The patients were randomly divided into the control (n=25) and observation (n=25) groups. Patients in the control group received conventional nursing, while those in the observation group received gelatin sponge combined with moist wound healing nursing. The effects of the two nursing methods were compared and analyzed. The results showed that the improvement rate of the observation group was significantly higher than that of the control group (P<0.05). The Branden score and area of pressure sore of the observation group were significantly lower than those of the control group (P<0.05). The frequency and time of dressing change and the average cost of hospitalization of the observation group were significantly lower than those of the control group (P<0.001). In conclusion, gelatin sponge combined with moist wound-healing nursing intervention may significantly improve the treatment of phase III bedsore.

BODY.INTRODUCTION:
Pressure sore refers to the tissue damage or necrosis that results from the lack of adequate nutrition caused by the body's long-term exposure to pressure and slacking blood circulation (1). Pressure sore is a common complication in patients with breast cancer (2). Major clinical treatments are traditional medicine and nursing intervention; however, the curative effects are not optimistic (3). In 1962, Dr Winter identified moist wound-healing nursing, which became widely used (4). Type I gelatin sponge has similar components with the connective tissues of the body. It can quickly promote tissue healing, realize rapid degradation, and has good biocompatibility characteristics; thus, it has been widely used in tissue engineering (4).  The aim of the present study was to examine the effects of gelatin sponge combined with moist wound-healing nursing intervention in the treatment of phase III bedsore.

BODY.MATERIALS AND METHODS.MATERIALS:
A total of 50 patients with phase III bedsore, treated at the Liaocheng People's Hospital between March 2013 and July 2014 were included in the study. All the patients conformed to the diagnostic criteria suggested by the National Pressure Ulcer Advisory Panel Society: entire skin defect without muscles, tendons or bones exposed, with or without incrustation and subcutaneous tunnel (6). Approval for the study was obtained from the ethics committee of Liaocheng People's Hospital. Informed consent was obtained from the patients and/or relatives.  The patients were randomly divided into the control (n=25) and observation (n=25) groups. The patient age range for the control group was 59–80 years, with an average of 68.0±6.5 years. In control group, 31 pressure sores were located in sacroiliac, 11 pressure sores in hip joint and 8 in ankle and foot. The Branden scores ranged from 10 to 22 points, with an average of 14.0±3.2 points, and the area of pressure sore ranged from (2×1 cm) to (10×8 cm). Concerning the observation group, the patient age range was 56–82 years, with an average age of 67.9±7.2 years. In those patients, 33 pressure sores were located in sacroiliac, 10 pressure sores in hip joint and 6 in ankle and foot. The Branden scores ranged from 11 to 24 points, with an average of 15.3±3.5 points, and the area of pressure sore ranged from (1.5×1.5 cm) to (10.5×7.5 cm). The differences in age, pressure sore sites, Branden score and area of pressure of the two groups were not statistically significant (P>0.05).

BODY.MATERIALS AND METHODS.NURSING METHODS:
Patients in the control group were provided conventional nursing care. Hydrogen peroxide or iodine was used for local disinfection and mechanical debridement to remove the purulent secretion of necrotic tissues, and ethacridine gauze was used to fill in the potential lacuna of the lacunar pressure sore. Aseptic dressing was used to cover the wound, and the dressing was changed once every 1–2 days.  The patients in the observation group received gelatin sponge combined with moist wound-healing nursing. The normal saline or cotton ball was used to clean the wound surface. The yellow wound surface (if any) was cleaned with surgical debridement (blade, or sterile scissors) to excise the necrotic tissues and the gelatin sponge to absorb seepage and cover the wound. In case of infection, gelatin sponge was soaked with silver ion alginate (Kanglebao Company, Guangzhou, China) was used to cover the yellow surface and the skin in or around the dressing was closely examined. If there was seepage and the milk white area was >1/3, the sponge (once/1–2 days) was changed in a timely manner after new granulation tissues appeared on the sponge. The area was washed again to apply the gelatin sponge once per week. Humanized nursing was strengthened gently and the patients were slowly turned over once every 2 h by elevating the bedside to maintain an angle within 30° to prevent exertion of excessive force on the sacral tail. The patients were kept dry and smooth, and an air cushion bed comprehensively improved the nutritional status of the patients. Subsequently, the patients were followed up and provided with health education prior to discharge from the hospital. Additionally, the patients and their families were informed of the risk factors of pressure sores.

BODY.MATERIALS AND METHODS.OBSERVATION INDICES AND EVALUATION STANDARD:
At 28 days later, the healing state of patients was closely examined including the curative effects, frequency of dressing change and efficiency of end point. The quantitative scoring was performed according to Pressure Ulcer Scale for Healing (7) compiled by the US pressure sore expert group and the curative effects were evaluated (Table I).

BODY.MATERIALS AND METHODS.STATISTICAL ANALYSIS:
SPSS 19.0 statistical software (SPSS, Inc., Chicago, IL, USA) was used for statistical analysis and data were presented as mean ± standard deviation. The comparison between the groups was made using the t-test. The enumeration data were expressed by percentage (%). A comparison between groups was made using the χ2 test. P<0.05 was considered to indicate a statistically significant difference.

BODY.RESULTS.COMPARISON OF HEALING EFFECTS:
The improvement rate of the observation group (92.0%) was significantly higher than that of the control group (68.0%) (Table I; P<0.05).

BODY.RESULTS.COMPARISON OF BRANDEN SCORES AND AREA OF PRESSURE SORE:
Prior to treatment, the Branden score and area of pressure sore of the control and observation groups were not statistically different (P>0.05). Following treatment, the Branden score and area of pressure sore of the observation group were significantly lower than those of the control group (P<0.05; Table II).

BODY.RESULTS.COMPARISON OF FREQUENCY AND TIME OF DRESSING CHANGE, AND COSTS:
The frequency, time of dressing change and average costs of hospitalization of the observation group (7.8±0.9, 20.9±8.4, and 2675.4±234.5, respectively) were significantly lower than those of the control group (16.2±2.7, 31.8±12.6, and 7826.5±1342.1, respectively) (P<0.001) as shown in Table III.

BODY.DISCUSSION:
Traditional cleaning, disinfection and other commonly used medical gauze, due to their poor moisture absorption, cannot be degraded in vivo and the prescription contains light powder that is toxic to liver and kidney (8). Gelatin sponge effectively absorbs the tissue fluid, and is favorable for local hemostasis. It can absorb water of 50-fold and blood of 48-fold its own weight. After absorbing a large amount of blood, gelatin sponge can promote the rupture of platelet, release a large number of platelet coagulation factors and promote blood coagulation (9). In addition, gelatin sponge supports the blood block to prevent it from decreasing, resulting in anastalsis (10). The gelatin sponge became jelly-like one week following application and was completely absorbed after 1–2 months. It could be left in the body and did not produce any antigenicity, excessive scar tissues or fibrotic reactions (11). Gelatin sponge is a also good drug carrier. Previous findings have shown that it promoted wound surface healing compared to the external application of Chinese medicine or gauze (12).  In the present study, the importance of moist healing nursing was also emphasized. Other studies on wound surface have confirmed that dryness can aggravate the degree of tissue damage while moisture was more favorable for the wound surface healing (13). Moisture can promote and accelerate natural healing and the healing speed in the moisture environment is faster than the dry environment. For the pressure sores of patients with breast cancer, the optimal way in which to restore the damaged epithelial tissues is to seal the moist wound, promote the growth of keratinocytes of the wounds and elevate the regenerative velocity by 40% (14). A moist environment is advantageous to the adhesion of dressing and wound surface, and would not damage the granulation tissue or wound epithelial tissue, relieving pain experienced by the patients (15).  Patients of the control group received sterile gauze caring. During dressing, gauze dressing was likely to adhere to the surface of the wound, rendering it unfavorable for seepage absorption, and excessive seepage also required frequent change of gauze. Patients of the observation group were provided with gelatin sponge caring, which effectively improved the absorption effects of seepage, kept the area of pressure sore in a closed space and avoid invasion and infection of external microorganisms (16). Patients of the observation group were also assisted by humanized nursing, such as psychological guidance and health education (17), and had nurse assistance in being turned over once every 2 h and keeping their skin smooth and dry. The above measures constitute a good treatment environment for breast cancer patients with pressure sores (18).  The results of the present study have shown that the improvement rate of the observation group was significantly higher than that of the control group, The Branden score and the area of pressure sore were significantly lower than those of the control group, and frequency and time of dressing change and average cost of hospitalization were significantly lower than those of the control group. These differences were statistically significant, thereby greatly reducing the workload of nursing personnel (19). In conclusion, gelatin sponge combined with moist wound-healing nursing intervention may significantly improve the healing of phase III bedsore.

Question: Compared to Control what was the result of Gelatin sponge + moist wound-healing on Branden score?
Evidence: The Branden score and area of pressure sore of the observation group were significantly lower than those of the control group (P<0.05).
Answer: significantly decreased