Question:  Darwin's Black Box: The Biochemical Challenge to Evolution is a book by an American biochemist best known for his argument for his stance on what?
Context: Arthur Beck Pardee (born July 13, 1921) is an American biochemist.  One biographical portrait  begins "Among the titans of science, Arthur Pardee is especially intriguing."  There is hardly a field of molecular biology that is not affected by his work, which has advanced our understanding through theoretical predictions followed by insightful experiments.  He is perhaps most famous for his part in the 'PaJaMo experiment' of the late 1950s, which greatly helped in the discovery of messenger RNA.  He is also well known as the discoverer of the restriction point, in which a cell commits itself to certain cell cycle events during the G1 cycle.  He has done a great deal of work on tumor growth and regulation, with a particular focus on the role of estrogen in hormone-responsive tumors.  And he is also well known for the development of various biochemical research techniques, most notably the differential display methodology, which is used in examining the activation of genes in cells.  More recently he has championed the acceptance and adoption of the conceptual review as a valuable approach to unearthing new knowledge from the enormous stores of information in the scientific literature. The Edge of Evolution: The Search for the Limits of Darwinism is an intelligent design book by Discovery Institute fellow Michael Behe, published by the Free Press in 2007.  Behe argues that while evolution can produce changes within species, there is a limit to the ability of evolution to generate diversity, and this limit (the "edge of evolution") is somewhere between species and orders.  On this basis, he says that known evolutionary mechanisms cannot be responsible for all the observed diversification from the last universal ancestor and the intervention of an intelligent designer can adequately account for much of the diversity of life.  It is Behe's second intelligent design book, his first being "Darwin's Black Box". Darwin's Black Box: The Biochemical Challenge to Evolution (1996; second edition 2006) is a book by Michael J. Behe, a professor of biochemistry at Lehigh University in Pennsylvania and a senior fellow of the Discovery Institute's Center for Science and Culture.  In the book Behe presents his notion of irreducible complexity and argues that its presence in many biochemical systems therefore indicates that they must be the result of intelligent design rather than evolutionary processes.  In 1993, Behe had written a chapter on blood clotting in "Of Pandas and People", presenting essentially the same arguments but without the name "irreducible complexity", which he later presented in very similar terms in a chapter in "Darwin's Black Box".  Behe later agreed that he had written both and agreed to the similarities when he defended intelligent design at the "Kitzmiller v. Dover Area School District" trial. Robert Kellogg Crane (December 20, 1919 – October 31, 2010) was an American biochemist best known for his discovery of sodium-glucose cotransport. Karl Paul Gerhard Link (31 January 1901 – 21 November 1978) was an American biochemist best known for his discovery of the anticoagulant warfarin. Xiaodong Wang (, born 1963) is a Chinese-born American biochemist best known for his work with cytochrome c.  His laboratory developed an in-vitro assay for the activation of the apoptosis related proteinase Caspase-3.  This allowed the biochemical purification of a complex of Cytochrome c, Caspase-9 and the Apoptotic Protease Activating factor-1 (APAF1).  These components are essential for forming a ternary complex called the apoptosome that activates Caspase-3 downstream of the intracellular or mitochondrial pathway of apoptosis. Emil L. Smith (July 5, 1911 – May 31, 2009) was an American biochemist who studied protein structure and function as well as biochemical evolution. Michael J. Behe ( ; born January 18, 1952) is an American biochemist, author, and intelligent design (ID) advocate.  He serves as professor of biochemistry at Lehigh University in Pennsylvania and as a senior fellow of the Discovery Institute's Center for Science and Culture.  Behe is best known for his argument for his stance on irreducible complexity (IC), which argues that some biochemical structures are too complex to be explained by known evolutionary mechanisms and are therefore probably the result of intelligent design.  Behe has testified in several court cases related to intelligent design, including the court case "Kitzmiller v. Dover Area School District" that resulted in a ruling that intelligent design was not science and was religious in nature. Harvey Akio Itano (November 3, 1920 – May 8, 2010) was an American biochemist best known for his work on the molecular basis of sickle cell anemia and other diseases.  In collaboration with Linus Pauling, Itano used electrophoresis to demonstrate the difference between normal hemoglobin and sickle cell hemoglobin; their 1949 paper "Sickle Cell Anemia, a Molecular Disease" (coauthored also with S. J. Singer and Ibert C. Wells) was a landmark in both molecular medicine and protein electrophoresis. Roger John Williams (August 14, 1893 – February 20, 1988), was an American biochemist who spent his academic career at the University of Texas at Austin.  He is known for isolating and naming folic acid and for his roles in discovering pantothenic acid, vitamin B6, lipoic acid, and avidin.  He served as the founding director of the Clayton Foundation Biochemical Institute from 1941 to 1963, was elected to the National Academy of Sciences in 1946, and served as the president of the American Chemical Society in 1957.  In his later career he spent time writing for a popular audience on the importance of nutrition.  His brother Robert R. Williams was also a distinguished chemist and is known for discovery of thiamine (vitamin B1).  Roger Williams is credited for emphasizing the "Biochemical Individuality" of each person with respect to their metabolic makeup and micronutrient needs.  It is also the title of one of his well known books that emphasizes the uniqueness of nutritional requirements from person to person based on their genetic makeup, lifestyle, medical history, diet, etc.
Answer: irreducible complexity