Question: In between Priceline.com and Edwards Lifesciences which one is mostly known for a transcatheter aortic heart valve made of bovine tissue?
Context: Apicoaortic Conduit (AAC), also known as Aortic Valve Bypass (AVB), is a cardiothoracic surgical procedure that alleviates symptoms caused by blood flow obstruction from the left ventricle of the heart.  Left ventricular outflow tract obstruction (LVOTO) is caused by narrowing of the aortic valve (aortic stenosis) and other valve disorders.  AAC, or AVB, relieves the obstruction to blood flow by adding a bioprosthetic valve to the circulatory system to decrease the load on the aortic valve.  When an apicoaortic conduit is implanted, blood continues to flow from the heart through the aortic valve.  In addition, blood flow bypasses the native valve and exits the heart through the implanted valved conduit.  The procedure is effective at relieving excessive pressure gradient across the natural valve.  High pressure gradient across the aortic valve can be congenital or acquired.  A reduction in pressure gradient results in relief of symptoms. Aortic valve replacement is a procedure in which a patient's failing aortic valve is replaced with an artificial heart valve.  The aortic valve can be affected by a range of diseases; the valve can either become leaky (aortic insufficiency) or partially blocked (aortic stenosis).  Current aortic valve replacement approaches include open heart surgery via a sternotomy, minimally invasive cardiac surgery (MICS) and transcatheter aortic valve replacement (TAVR). The aortic valve is a valve in the human heart between the left ventricle and the aorta.  It is one of the two semilunar valves of the heart, the other being the pulmonary valve.  The heart has four valves and the other two are the mitral and the tricuspid valves.  The aortic valve normally has three cusps or leaflets, although in 1–2% of the population it is found to congenitally have two leaflets. Priceline.com is an American company and a commercial website that helps users find discount rates for travel-related purchases such as airline tickets and hotel stays.  The company is not a direct supplier of these services; instead it facilitates the provision of travel services by its suppliers to its customers.  It is headquartered in Norwalk, Connecticut, United States.  Priceline.com is wholly owned by The Priceline Group. Edwards Lifesciences is an American medical equipment company specializing in artificial heart valves and hemodynamic monitoring.  It is mostly known for a transcatheter aortic heart valve made of bovine tissue within a collapsible stainless-steel stent, deployed via catheter. Alain Cribier, M.D., FACC, FESC (born 1945) is a French interventional cardiologist, who is a Professor of Medicine and Director of Cardiology at the University of Rouen's Charles Nicolle Hospital.  Alain Cribier is best known for developing and performing the world's first transcatheter aortic valve implantation in 2002, the first mitral commissurotomy in 1995 and the first balloon aortic valvuloplasty in 1986. Percutaneous aortic valve replacement (PAVR), also known as transcatheter aortic valve implantation (TAVI) or transcatheter aortic valve replacement (TAVR), is the replacement of the aortic valve of the heart through the blood vessels (as opposed to valve replacement by open heart surgery).  The John G. Webb, M.D., FRCPC is a Canadian interventional cardiologist and the McLeod Professor of Heart Valve Intervention at the University of British Columbia.  He is most well known for performing the first transfemoral and the first transapical transcatheter aortic valve implantation in the world both in 2005.  He completed the first ever transcatheter mitral valve-in-valve replacement in 2009 and the first transcatheter mitral valve replacement in 2014.  In addition, he was an investigator in the PARTNER trial, a randomized clinical trial demonstrating the efficacy of TAVI compared to aortic valve replacement and medical intervention. The pericardial heart valve was invented by Marian Ionescu, a British surgeon working at the General Infirmary in Leeds, England.  He created this artificial bioprosthetic heart valve as a three-cusp structure made of chemically treated bovine pericardium attached to a Dacron cloth-covered titanium frame. Richard Whitlock, M.D., Ph.D., FRCSC is a Canadian cardiovascular surgeon and an Associate Professor of Surgery at McMaster University Medical School.  He is most well known for being the principal investigator of the SIRS (Steroids in Cardiac Surgery) trial and the LAAOS III (Left Atrial Appendage Occlusion Study) trial.  On April 9, 2015, Whitlock and his team performed the first transcatheter aortic valve implantation on a pregnant woman in the world.
Answer: Edwards Lifesciences