Question: Between two Americans, Mameve Medwed and Sherman Alexie, who works in a broader range of arts?
Context: The Lone Ranger and Tonto Fistfight in Heaven is a 1993 collection of interconnected short stories by Sherman Alexie.  The characters and stories in the book, particularly "This Is What It Means to Say Phoenix, Arizona", provided the basis of Alexie's screenplay for the film "Smoke Signals". Epoxygenases are a set of membrane-bound, heme-containing cytochrome P450 (CYP P450 or just CYP) enzymes that metabolize polyunsaturated fatty acids to epoxide products that have a range of biological activities.  The most thoroughly studied substrate of the CYP epoxylgenases is arachidonic acid.  This polyunsaturated fatty acid is metabolized by cyclooxygenases to various prostaglandin, thromboxane, and prostacyclin metabolites in what has been termed the first pathway of eicosanoid production; it is also metabolized by various lipoxygenases to hydroxyeicosatetraenoic acids (e.g. 5-Hydroxyeicosatetraenoic acid, 12-Hydroxyeicosatetraenoic acid, 15-hydroxyicosatetraenoic acid) and leukotrienes (e.g. leukotriene B4, leukotriene C4) in what has been termed the second pathway of eicosanoid production.  The metabolism of arachidonic acid to epoxyeicosatrienoic acids by the CYP epoxygenases has been termed the third pathway of eicosanoid metabolism.  Like the first two pathways of eicosanoid production, this third pathway acts as a signaling pathway wherein a set of enzymes (the epoxygenases) metabolize arachidonic acid to a set of products (the eicosatrienoic acid epoxides, abbreviated as EETs, which are classified as nonclassic eicosanoids) that act as secondary signals to work in activating their parent or nearby cells and thereby orchestrate functional responses.  However, none of these three pathways is limited to metabolizing arachidonic acid to eicosanoids.  Rather, they also metabolize other polyunsaturated fatty acids to products that are structurally analogous to the eicosanoids but often have different bioactivity profiles.  This is particularly true for the CYP epoxygenases which in general act on a broader range of polyunsaturated fatty acids to form a broader range of metabolites than the first and second pathways of eicosanoid production.  Furthermore, the latter pathways form metabolites many of which act on cells by binding with and thereby activating specific and well-characterized receptor proteins; no such receptors have been fully characterized for the epoxide metabolites.  Finally, there are relatively few metabolite-forming lipoxygenases and cyclooxygenases in the first and second pathways and these oxygenase enzymes share similarity between humans and other mammalian animal models.  The third pathway consists of a large number of metabolite-forming CYP epoxygenases and the human epoxygenases have important differences from those of animal models.  Partly because of these differences, it has been difficult to define clear roles for the epoxygenase-epoxide pathways in human physiology and pathology. Reservation Blues is a 1995 novel by American writer Sherman Alexie (Spokane-Coeur d'Alene).  The novel follows the story of the rise and fall of a rock and blues band of Spokane Indians from the Spokane Reservation.  In 1995, Thomas Builds-The-Fire, Junior Polatkin, and Victor Joseph, who also appear in Sherman Alexie's short story collection "The Lone Ranger and Tonto Fistfight in Heaven," meet American blues musician Robert Johnson.  He sold his soul to the devil in 1931 and claims to have faked his death seven years later.  The three boys start a rock and blues band in Spokane using Johnson's enchanted guitar. Ten Little Indians is a 2004 short story collection by Sherman Alexie.  The collection contains nine stories all of which focus on the Spokane tribe of Native Americans in Washington state. Jim Boyd (1956 – June 22, 2016) was a Native American singer-songwriter, actor, and member of The Jim Boyd Band on the Colville Indian Reservation in Washington.  Boyd has performed in several groups, including XIT, Greywolf, and Winterhawk.  Boyd sang four songs with lyrics by Sherman Alexie on the soundtrack for the 1998 movie "Smoke Signals", and also appeared in Alexie's "The Business of Fancydancing". Esther Belin (born 1968) is a Diné multimedia artist and writer.  She is a graduate of the Institute of American Indian Arts in Santa Fe, New Mexico, as well as the University of California, Berkeley.  She is the author of a collection of poetry, "From the Belly of My Beauty," published in 1999 by the University of Arizona Press.  The book won the American Book Award from the Before Columbus Foundation in 2000.  According to a review from "Library Journal", "Belin provides graphic descriptions of the 'wounds' one endures remaining true to a 'native lifestyle.'"  Sherman Alexie considers Belin to be one of his favorite Native writers. Longhouse Media is a Washington State non-profit indigenous media arts organization, based in Seattle.  It was established in January 2005 by Executive Director, Tracy Rector and former Artistic Director, Annie Silverstein, with the support of the Swinomish Indian Tribal Community.  Longhouse Media supports the use of today’s technologies by indigenous people and communities as a tool for self-expression, cultural preservation, and social change.  Longhouse Media counts 4 full-time and 3 part-time staff, 30 active volunteers, and 8 board members.  Among the founding board members is award-winning author, playwright and poet Sherman Alexie, from the Spokane/Coeur d'Alene Tribes. Sherman Joseph Alexie, Jr. (born October 7, 1966) is a Spokane-Coeur d'Alene-American novelist, short story writer, poet, and filmmaker.  Much of his writing draws on his experiences as an Indigenous American with ancestry from several tribes.  He grew up on the Spokane Indian Reservation and now lives in Seattle, Washington. The Absolutely True Diary of a Part Time Indian is a 2007 novel for young adults written by Sherman Alexie and illustrated by Ellen Forney.  The book won several awards, and was the first young adult fiction work by Alexie, a stand-up comedian, screenwriter, film producer, and songwriter who has previously written adult novels, short stories, poems, and screenplays.  Alexie stated, "I did [write the book] because so many librarians, teachers, and teenagers kept asking me to write one." Mameve Medwed is an American novelist.  Born and raised in Bangor, Maine, she received her B.A. with honors from Simmons College and now lives in Cambridge, Massachusetts.  She is the author of "Mail", "Host Family", "The End of an Error", "How Elizabeth Barrett Browning Saved My Life" (for which she received a 2007 Massachusetts Book Awards Fiction Honor), and "Of Men and Their Mothers".
Answer: Sherman Joseph Alexie, Jr.