Question: The Casa De Josefina (also known as the Irwin Arthur Yarnell House) is a historic home near Lake Wales, Florida, it is located two miles southeast of Lake Wales off which north–south United States highway, in the southern and midwestern United States?
Context: The Roosevelt School (also known as the Roosevelt Academy) is a historic school in Lake Wales, Florida.  It is located at 115 E Street.  On March 29, 2001, it was added to the U.S. National Register of Historic Places.  Originally this school served the African-American Community or the Northwest community in Lake Wales.  Currently it is an ESE vocational school specifically designed to teach and train students in grades 6-12 with learning disabilities to adapt and excel in society U.S. Route 65 is a north–south United States highway in the southern and midwestern United States.  The southern terminus of the route is at U.S. Route 425 in Clayton, Louisiana.  The northern terminus is at Interstate 35 just south of Interstate 90 in Albert Lea, Minnesota.  Parts of its modern route in Iowa and historic route in Minnesota follow the old Jefferson Highway. Tower Lakes can be considered either one or two lakes, since they consist of a north and a south lake joined by a narrow water passage.  Tower Lakes is a landscaping feature of the Tower Lakes Adult Mobile Home Community, just north of Lake Wales, Florida.  The mobile home park is just east of US Highway 27; the only park entrance can only be accessed from the highway.  This mobile home park, for residents fifty-five years and older, contains approximately 500 mobile homes and about 1000 residents during the peak season for winter visitors (December through March).  The community has a large clubhouse on the east side of Tower Lakes just south of where the two parts are joined.  The water has a 4.1 acre surface area.  The north lake has almost twice the surface area of the south lake.  The north lake is shaped like a backwards small "y" and the south lake is shaped like a capital "R." The two lakes are joined at the center of the bottom of the "y" and the top of the "R." Florida sand pine scrub is an endangered subtropical forest ecoregion found throughout Florida in the United States.  It is found on coastal and inland sand ridges and is characterized by an evergreen xeromorphic plant community dominated by shrubs and dwarf oaks. Because the low-nutrient sandy soils do not retain moisture, the ecosystem is effectively an arid one.  Wildfires infrequently occur in the Florida scrub.  Most of the annual rainfall (about 135 cm ) falls in summer.  It is endangered by residential, commercial and agricultural development, with the largest remaining block in and around the Ocala National Forest.  Lake Wales Ridge National Wildlife Refuge also holds a high proportion of remaining scrub habitat, while the Archbold Biological Station near Lake Placid contains about 20 km2 of scrub habitat and sponsors biological research on it. The Lake Wales Ridge National Wildlife Refuge is part of the United States National Wildlife Refuge System, located in four separated areas on the Lake Wales Ridge east of US 27 between Davenport and Sebring Florida.  The 1,194 acre (4.8 km) refuge was established in 1990, to protect a host of plants and animals.  It is also the first to be designated primarily for the preservation of endangered plants, and is not open to the general public.  It contains a high proportion of remaining Florida scrub habitat.  It is administered as part of the Merritt Island National Wildlife Refuge. The Casa De Josefina (also known as the Irwin Arthur Yarnell House) is a historic home near Lake Wales, Florida.  It is located two miles southeast of Lake Wales off U.S. 27.  On June 10, 1975, it was added to the U.S. National Register of Historic Places. U.S. Route 63 (US 63) is a 1286 mi north–south United States highway primarily in the Midwestern United States.  The southern terminus of the route is at Interstate 20 in Ruston, Louisiana.  The northern terminus is at U.S. Route 2 in Benoit, Wisconsin, about 60 mi east of Duluth, Minnesota. The Lake Wales Ridge, sometimes referred to as the Mid-Florida Ridge, is a sand ridge running for about 150 miles south to north in Central Florida.  Clearly viewable from satellite, the white sands of the ridge are located in Highlands County and Polk County, and also extends north into Osceola, Orange, and Lake Counties.  It is named for the city of Lake Wales, roughly at the midpoint of the ridge.  The highest point of the ridge is Sugarloaf Mountain, which at 312 feet (95 meters) is also the highest point in peninsular Florida.  Iron Mountain, the location of Bok Tower, marks another well known high point on the ridge, attaining an elevation of 295 feet (90 meters). Casa de Oro is a neighborhood in east San Diego County, California, United States.  The community, twelve miles east of San Diego, is divided between the unincorporated town of Spring Valley and an unincorporated part of La Mesa.  The United States Census Bureau has also divided the neighborhood between two census-designated places (CDPs), Spring Valley CDP and Casa de Oro-Mount Helix CDP.  Casa de Oro's main thoroughfare is Campo Road. U.S. Route 27 (US 27) is a north–south United States highway in the southern and midwestern United States.  The southern terminus is at US 1 in Miami, Florida.  The northern terminus is at Interstate 69 (I-69) in Fort Wayne, Indiana.  From Miami it goes up the center of Florida, then west to Tallahassee, Florida, and north through such cities and towns as Columbus, Georgia; Rome, Georgia; Chattanooga, Tennessee; Lexington, Kentucky; Cincinnati, Ohio; Oxford, Ohio; Richmond, Indiana; and Fort Wayne, Indiana.  It once extended north through Lansing, Michigan, to Cheboygan, Mackinaw City, and for about 3 years as far as St. Ignace.
Answer: U.S. Route 27