Question: What major port founded in 1533 was Nicolas De la Hoz born in?
Context: Renato Patricio González De La Hoz (born 19 February 1990) is a Chilean footballer that currently plays for San Marcos of the Primera B de Chile. Sanare is a major city and the seat of government in the municipality of Andrés Eloy Blanco in Lara State, Venezuela.  Andrés Eloy Blanco is further subdivided into three parishes: Pio Tamayo (in which Sanare is the main city), Yacambú, and La Quebrada Honda del Guache.  Sanare was founded in 1620 by the friar Dominico Melchor Ponce de Leon following the orders of the governor Don Francisco de la Hoz Berrio [disputed statement]. Miguel Angel de la Hoz Piloto (born October 2, 1938 in Havana, Cuba) is a former Major League Baseball infielder. Pedro Sánchez de la Hoz (Calahorra, La Rioja, 1514 - Santiago de Chile, 1547) was a Spanish merchant, conquistador and adelantado.  In 1534 he obtained the rights of a capitulación south of the Straits of Magellan.  Sánchez de la Hoz had a conflictive relation with rival conquistador Pedro de Valdivia.  In 1547 Francisco de Villagra, one of Valdivia's men, had Sánchez de la Hoz executed. La Hoz de la Vieja is a municipality located in the province of Teruel, Aragon, Spain.  According to the 2004 census (INE), the municipality has a population of 108 inhabitants. The city of Cartagena, known in the colonial era as Cartagena de Indias (Spanish: "Cartagena de Indias" ] ), is a major port founded in 1533, located on the northern coast of Colombia in the Caribbean Coast Region.  It was strategically located between the Magdalena and Sinú rivers and became the main port for trade between Spain and its overseas empire, establishing its importance by the early 1540s.  During the colonial era it was a key port for the export of Peruvian silver to Spain and for the import of African slaves.  It was defensible against pirate attacks in the Caribbean.  It is the capital of the Bolívar Department, and had a population 971,592 as of 2016.  It is the fifth-largest city in Colombia and the second largest in the region, after Barranquilla.  The urban area of Cartagena is also the fifth-largest urban area in the country.  Economic activities include the maritime and petrochemicals industries, as well as tourism. Nicolas de Besse was born in the diocese of Limoges, in 1322.  He was a French bishop and Cardinal.  He was the son of Jacques de Besse, Seigneur de Bellefaye and Almodie (Delphine) Roger, sister of Pope Clement VI.  He had a brother Pierre de Besse, who became Seigneur de Bellefaye and who married Margueritte de Thiers.  Nicolas de Besse died in Rome on 5 November 1369. Balaoan Church also known as the San Nicolas de Tolentino Church is a Roman Catholic church located in Balaoan, La Union, Philippines under the jurisdiction of the Roman Catholic Diocese of San Fernando de La Union.  It used to be called "Purao", and is under the advocacy San Nicolas de Tolentino. Rafael Nicolás De la Hoz (born 1960 in Cartagena) is a Colombian artist.  Most of his childhood was spent in Barranquilla and Bogotá.  In 1984, he studied drawing and painting in the private workshop of David Manzur. El Piñón is a town and municipality of the Colombian Department of Magdalena.  Officially founded in 1760 by Francisco Sayas, Ignacio Crespo, Vicente De la Hoz and others.  On April 20, 1915 was proclaimed a municipality.  Its economy is based on agriculture and farming.  Its main tourist attraction is the Iglesia San Pedro Mártir (Saint Peter the Martir Church) and the Ave Maria Monument.  The town celebrates carnivals, the Saint Peter of Verona Day in April, El Milagroso in September, the Unedited Song Festival and the Decimates Festival.
Answer: Cartagena