Question: What artist painted the sets of watercolors that she made exploring a monochromatic palette with designs that were non-representational of specific objects, and was best known for her paintings of enlarged flowers? 
Context: Georgia Totto O'Keeffe (November 15, 1887 – March 6, 1986) was an American artist.  She was best known for her paintings of enlarged flowers, New York skyscrapers, and New Mexico landscapes.  O'Keeffe has been recognized as the "Mother of American modernism". Vija Celmins is an acclaimed Latvian-American visual artist best known for photo-realistic paintings and drawings of natural environments and phenomena such as the ocean, spider webs, star fields, and rocks.  Her earlier work included pop sculptures and monochromatic representational paintings.  Based in New York City, she has been the subject of over forty solo exhibitions since 1965, and major retrospectives at the Museum of Modern Art, Whitney Museum of American Art, Los Angeles County Museum of Art, Institute of Contemporary Arts, London, and Centre Pompidou, Paris. Doretta Frenna Smith (1924–2012) was an artist born and raised in Trieste, Italy.  She was known for her impressionist realism watercolors.  Her higher education in Italy includes; Magistrale Institute, The Technical Institute of Accounting, Commercial Institute of Comtometry, Berliz School of Languages, Enenkel School of Art and Design and Popolare University.  She married an American serviceman at the end of World War Two in Trieste Italy and moved to the United States in December 1948 and settled in Jacksonville, North Carolina where she lived out her life.  She put her work aside for several years to raise eight children.  Being inspired in 1971 while watching her oldest son graduate from East Carolina University, she resumed her studies by attending art lectures, demonstration classes from regionally known artists, as well as attending classes at St John Museum of Art in Wilmington NC, Coastal Carolina Community College in Jacksonville NC, Pitt Technical Institute in Greenville NC and Fayetteville Technical Institute.  She greatly valued the opportunity to attend an art seminar conducted by Fredrick Taubes of New York City which inspired her style.  In 1973 She began teaching art at Coastal Carolina Community College until 1978 where she turned to painting full-time.  Her life in Italy during World War II had a profound effect on her work.  She used her art to help her erase the memories of the war.  Her first set of paintings where scenes from her childhood, that she called her "Italian Collection".  Most of the "Italian Collection" were oil paintings, a media that she used early in her career before switching to watercolor.  In the late 1970s she began painting local scenes of eastern North Carolina, floral and other areas of interest.  She often painted with opera playing in the background and had commented that the music creates the mood that she would translate visually.  Her watercolors often produced startling results which added to the spiritual dimension while leaving something to the imagination of the viewer.  Her awards for her art are in the hundreds with numerous one person shows.  She had many private collectors from all around the world to include, Italy, Germany, South America, China and Russia. Isabel Iacona (born Buenos Aires, 1955) is an Argentine artist known for her detailed paintings of enlarged flowers and pop portraits of people and pets.  She uses several mediums: oil on canvas, mixed techniques, watercolors and drawings.  Her works have been commissioned in Europe and the Americas and she has lived in several countries. Conor Matthew Mccreedy (born 11 February 1987) in Johannesburg, South Africa.  Mccreedy is an artist, entrepreneur and collector.  He is recognised for his paintings made in varying shades of blue known as "Mccreedyblue".  His signature style, also known as "Mccreedyfied", depicts abstract figures and sometimes people in monochromatic shades with expressive and detailed gestures.  He has exhibited at the National Arts Club, a private club in New York City.  In 2017 Sotheby's auctioned one of his paintings titled Indian Ocean Explosions. Cuthy Mede is a Malawian artist.  Lonely Planet said "possibly the best-known [Malawian] artist is Cuthy Mede – he is also actively involved in the development and promotion of Malawian art within the country and around the world."  Cuthy Mede grew up on Likoma Island, Lake Malawi where he drew in the rough sands of the beach as a child.  Later he studied Fine Art in Chancellor College and became a lecturer at the College in the 1970s.  By the 1980s Mede established Gallerie Africaine in Lilongwe City Centre, the first art gallery by a local artist in Malawi.  Mede exhibited his work widely in Malawi, becoming a successful artist selling his work to international collectors.  Mede encouraged the work of young Malawian artists struggling to make a living selling folk art and wood carvings as street traders.  He also brought fine art work from other Malawian artists into his Gallery.  He was commissioned to paint a large mural decorating the City Centre.  Mede is best known for his modern art styles: modern, futurist, cubist and pointillist, with strong local themes.  His paintings depicted local people, historic events and current events in Malawi, Biblical references with local interpretations, indigenous religious expressions, and paintings about ideas such as Justice, Greed, Man and Machine.  His paintings depict famine, refugees from Mozambique during the Civil War, voting and democracy, wedding celebration, spirits and possession, and the Nyau masquerade.  Mede's less known work is realistic, including a reproduction of the Mona Lisa.  His best known work is dominated by bright primary colors, cubist style, though his pointillist work favors ochres and softer tones in the overall effect.  In later years Mede painted mostly in shades of blue, then white on white, the purest light.  Mede is an evangelical Christian and his work begins with a point of light from which the rest of the painting flows, the energy from God.  This point of light is evident in most of his paintings as a single dot, a sun or moon, or an orb.  Best known for his paintings, Mede also produced sculptural forms such as wood figures covered in beads and pigments.  His garden in Lilongwe was made into a work of art, in white and light, with fluorescent light tubes hanging from trees and white painted rocks lining the drive and entry.  Mede's wife, Esther (deceased 2009), served as Principal Secretary for the Ministry of Research and Environmental Affairs in the Malawi government. Blue is the name of four paintings that Georgia O'Keeffe made in 1916.  It was one of the sets of watercolors that she made exploring a monochromatic palette with designs that were non-representational of specific objects.  The paintings were made on 15 7/8 x 11 inch sheets of Japanese tissue of the gampi tree. Georgia O'Keeffe is best known for her close-up,or large-scale flower paintings, which she painted from the mid-1920s through the 1950s.  She made about 200 paintings of flowers of the more than 2,000 paintings that she made over her career.  One of her paintings, "Jimson Weed", sold for $44.4 million, making it the most expensive painting sold of a female artist's work . Martha Elizabeth Burchfield Richter (June 28, 1924 – April 10, 1977) was an American watercolorist, the daughter of artist Charles Ephraim Burchfield (1893-1967).  Similarly to her father, Burchfield had an affinity for flowering plants, trees and landscapes.  She painted almost exclusively with watercolors and is known for her depictions of nature throughout the seasons, and landscapes of rural America.  She is known by the customary signature "M. Burchfield" on all her paintings.  Including those painted after the change of her surname following her marriage in 1946 to Henry Richter. Elizabeth Gowdy Baker (1860-1927) was an American portrait painter.  Born at Xenia, Ohio, she studied at the Cooper Union, Art Students' League, New York School of Art, Pennsylvania Academy of the Fine Arts in Philadelphia, Cowles Art School in Boston; under Frederick Freer, William Chase, and Harry Siddons Mowbray.  She medaled at Cooper Union.  She was a member of the Boston Art Students' Association and the Art Workers' Club for Women, New York.  This artist painted numerous portraits and was especially successful with pictures of children.  She had a method of her own, claiming that it was excellent for life-size portraits in watercolors.  The paper she used was heavier than any made in the US at the time, and was imported.  Her watercolors were very strong.  She stated that in this method, she got "the strength of oils with the daintiness of water-colors, and that it is beautiful for women and children, and sufficiently strong for portraits of men".  She rarely exhibited, and her portraits were kept in private houses.
Answer: Georgia Totto O'Keeffe