anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Pelvic floor dysfunctions (PFD) are highly prevalent among females who do athletics, a sport requiring jumping, strength, and running. Although educational approaches are useful options, the educational need for this particular population remains unknown. The objective of the present study was to describe the level of knowledge regarding PFD and its relationship with symptomatology and gender stereotypes in female athletes in Spain. A total of 255 female athletes completed an anonymous online survey to explore their knowledge regarding urinary incontinence (UI), pelvic organ prolapse (POP), anal incontinence (AI), and sexual dysfunction (SexD), as well as their PFD symptoms and gender stereotyped beliefs related to sport. Educational level and sports characteristics (training volume, experience, and athletic modality) were also explored. Participants demonstrated a low level of knowledge in terms of POP (52.5%), AI (64.0%), and SexD (40%), but not for UI (70.8%). The proportion of PFD complaints was 63.5% for dyspareunia, 51.8% for urine leakage, 42.4% for pelvic pain, 17.3% for AI, and 9.0% for POP, with no associations with knowledge (p > 0.05). Lower knowledge about UI and SexD was related to greater gender stereotypes (p < 0.05) and rejection of professional healthcare (p = 0.010). As a conclusion, the level of knowledge about PFD was low in female athletes who train and compete in athletics in Spain, mainly with regard to sexual dysfunction. Although 63.5% of athletes had dyspareunia and 51.8% urinary leakages, symptomatology was not associated with level of knowledge. However, a lower level of knowledge was associated with more stereotyped beliefs and rejection of professional healthcare for PFD. These findings confirm the need to design appropriate educational interventions to disseminate information on all the types of PFD, particularly sexual contents. The potential influence of gender stereotypes makes it appropriate to include the gender perspective in these interventions.
The microbiome-gut-brain axis is related to schizophrenia (SCZ). The role of intestinal mycobiota in SCZ has been under investigated. We present a half-year follow-up study involving 109 chronic SCZ patients and 77 healthy controls. Intestinal mycobiota was tested by internal transcribed spacer (ITS). Untargeted liquid chromatography-mass spectrometry (LC-MS) was used to measure fecal metabolites. Symptom severity was assessed using the Positive and Negative Syndrome Scale. Enterotype analysis showed that Candida-type patients exhibited severer positive symptoms and depression factors than Saccharomyces-type patients. Candida and its top species and operational taxonomic units (OTUs) were positively correlated with depression factors (all p=0.001). Fecal metabolites analysis showed that upregulated metabolites were associated with chronic inflammation (NF-κB pathway and T helper cell differentiation), downregulated metabolites were associated with glutamate metabolism, serotonergic and dopaminergic synapse. Procrustes analysis revealed significant correlation between intestinal mycobiota and fecal metabolites (M2=0.937, p<0.001). Metabolic module analysis showed that the top module, MEturquoise (associated with Th1 and Th2 cell differentiation), was negatively correlated with SCZ (r=-0.783, p<0.0001), positively correlated with Candida, Aspergillus, Trichosporon and Talaromyces (decreased in SCZ) and negatively correlated with Saccharomyces (increased in SCZ). We also found impairments of intestinal barrier in SCZ, characterized by increased in blood D-lactate (mucosa impairment marker) and decreased in blood mucin 2 (mucosal barrier protective protein). Serum levels of TNF-α was increased and showed stable high levels during treatment. This study suggests that mycobiota dysbiosis-related chronic inflammation and an impaired intestinal mucosal barrier are associated with chronic SCZ.
Subjects will be randomized to receive 10 sessions of either active or sham tDCS. Stimulation will be given on consecutive days (Monday- Friday) at 2 mA over the primary motor cortex area.
In the controlled clinical trials of valsartan, 1,214 (36.2%) hypertensive patients treated with valsartan were ≥ 65 years and 265 (7.9%) were ≥ 75 years. No overall difference in the efficacy or safety of valsartan was observed in this patient population, but greater sensitivity of some older individuals cannot be ruled out. Exposure [measured by area under the curve (AUC)] to valsartan is higher by 70% in the elderly than in the young, however no dosage adjustment is necessary  [see Clinical Pharmacology ( 12.3)]. 

  


Of the 2,511 patients with heart failure randomized to valsartan in the Valsartan Heart Failure Trial, 45% (1,141) were 65 years of age or older. In the VALsartan In Acute myocardial iNfarcTion trial (VALIANT), 53% (2,596) of the 4,909 patients treated with valsartan and 51% (2,515) of the 4,885 patients treated with valsartan + captopril were 65 years of age or older. There were no notable differences in efficacy or safety between older and younger patients in either trial.
Recruitment maneuver ( RM) will carried out during 2 minutes with increasing PEEP in stepwise manner.PEEP increase from 5 to 10 cmH2O (3 breaths),then to 15 cm H2O (3 breaths), PEEP to 20 cmH2O (10 breaths).Then decrease by 5 cmH2O every 3 breaths till back to preset PEEP 5 cmH2O .Recruitment carried out at the following times: post intubation(T1) , after insuflation(T2) ,after desuflation (T3) and before extubation(T4) . The peak airway pressure should not exceed 40cmH2O .
Monitoring vital signs via machine learning is provided. A system can identify data points of signals detected via skin of a user by an optical sensor that indicate changes in volume of blood flowing through a capillary at the skin. The system generates features from the data points. The system inputs the features into a model to produce output. The model can be trained using training data including features and labels corresponding to blood pressure measurements from a reference device. The system determines a value of blood pressure for the user based on the output from the model. The system provides an indication of the value of blood pressure via an interface.
Common variable immunodeficiency (CVID) is the most common symptomatic antibody deficiency, characterized by heterogeneous genetic, immunological, and clinical phenotypes. It is no longer conceived as a sole disease but as an umbrella diagnosis comprising a spectrum of clinical conditions, with defects in antibody biosynthesis as their common denominator and complex pathways determining B and T cell developmental impairments due to genetic defects of many receptors and ligands, activating and co-stimulatory molecules, and intracellular signaling molecules. Consequently, these genetic variants may affect crucial immunological processes of antigen presentation, antibody class switch recombination, antibody affinity maturation, and somatic hypermutation. While infections are the most common features of pediatric CVID, variants in genes linked to antibody production defects play a role in pathomechanisms of immune dysregulation with autoimmunity, allergy, and lymphoproliferation reflecting the diversity of the immunogenetic underpinnings of CVID. Herein, we have reviewed the aspects of genetics in CVID, including the monogenic, digenic, and polygenic models of inheritance exemplified by a spectrum of genes relevant to CVID pathophysiology. We have also briefly discussed the epigenetic mechanisms associated with micro RNA, DNA methylation, chromatin reorganization, and histone protein modification processes as background for CVID development.
The invention constructs recombinant plasmid vector containing tumstatin T7 peptide and gene sequence of derivative T7-NGR thereof and obtains recombinant T7 peptide and T7-NGR fusion protein. The amino acid sequence of the derivative T7-NGR is TMPFLFCNVNDVCNFASRNDYSYWLGSCNGRCVSGCAGRC. The invention combines the generation activity of tumstatin T7 peptide for restricting the tumor neovascularization effectively and high specificity of NGR guide peptide, so as to lead the generation activity of T7 peptide for restricting the  tumor neovascularization to be greatly strengthened. The recombinant cloned vectors are respectively identified by sequencing: the direction, position and sequence of integration are correct. The expression vector is transformed into competent E.coli BL21 (DE3) and then is expressed by the induction of IPTG; electrophoresis is carried out on the thalli after cracking; and by Western-Blot identification, the expression product is in accordance with the expected. The pET7N expression vector fusion protein T7-NGR has potential application prospect in the diagnosis and treatment of tumor.
Techniques are described for image analysis and representation for emotional metric threshold generation. A client device is used to collect image data of a user interacting with a media presentation, where the image data includes facial images of the user. One or more processors are used to analyze the image data to extract emotional content of the facial images. One or more emotional intensity metrics are determined based on the emotional content. The one or more emotional intensity metrics are stored into a digital storage component. The one or more emotional intensity metrics, obtained from the digital storage component, are coalesced into a summary emotional intensity metric. The summary emotional intensity metric is represented.
1,161,896. Thyroid gland polypeptides. I. MACINTYRE. 24 Aug., 1966 [26 Aug., 1965; 7 Jan., 1966; 11 July, 1966],. No. 37968/ 66. Heading A5B. A hypocalcaemic polypaptide is obtained from mammalian thyroid gland by extraction with aqueous acid, salt fractionation of the extract, and absorption on gel and elution therefrom in formic acid solution, followed by lyophilisation or evaporation to give the product. The process preferably includes a dialysis of the acid extract, and precipitation with trichloracetic acid at any stage subsequent to the salt fractionation. The preferred starting material is a defatted acetone powder of pigs' thyroid. The polypeptide has a molecular weight of about 2700, and contains most common L-amino acides excepting cystine. Pharmaceutical compositions comprise the polypeptide or its physiologically tolerable acid addition salts or complexes with a carrier, in a form suitable for internal or parenteral administration, and may also contain further unspecified active ingredients. The polypeptide may be reacted with bases or acids, or may be complexed with e.g. hydroxypolygelatin, polyvinyl pyrrolidone, Protamine, polyphloretin phosphate, phytic acid, polyglutamic acid, or suitable sparingly soluble metal compounds; such as Al, Mg, Co, or Zn phosphates, pyrophosphates or hydroxides, to provide, prolonged release forms.
Patients with apnea-hypopnea index (AHI) ≥ 15/hr on home sleep study will participate in a dietitian-led lifestyle modification program (LMP) for 6 months. Patients will attend dietary consultation weekly in the first 4 months, and then monthly in the following two months.
Central respiratory chemoreceptors are cells in the brain that regulate breathing in relation to arterial pH and PCO2. Neurons located at the retrotrapezoid nucleus (RTN) have been hypothesized to be central chemoreceptors and/or to be part of the neural network that drives the central respiratory chemoreflex. The inhibition or ablation of RTN chemoreceptor neurons has offered important insights into the role of these cells on central respiratory chemoreception and the neural control of breathing over almost 60 years since the original identification of acid-sensitive properties of this ventral medullary site. Here, we discuss the current definition of chemoreceptor neurons in the RTN and describe how this definition has evolved over time. We then summarize the results of studies that use loss-of-function approaches to evaluate the effects of disrupting the function of RTN neurons on respiration. These studies offer evidence that RTN neurons are indispensable for the central respiratory chemoreflex in mammals and exert a tonic drive to breathe at rest. Moreover, RTN has an interdependent relationship with oxygen sensing mechanisms for the maintenance of the neural drive to breathe and blood gas homeostasis. Collectively, RTN neurons are a genetically-defined group of putative central respiratory chemoreceptors that generate CO2-dependent drive that supports eupneic breathing and stimulates the hypercapnic ventilatory reflex.
PURPOSE:To obtain the subject cathartic having a mild effect after administration, capable of activating peristaltic movement of the intestinal wall while controlling evacuating force of the intestinal wall and entirely free from a side effect by blending various raw materials, i.e., Magnoliae cortex, Armeniacae Semen, Poncirus trifoliata, Rheum spp. and Angelica actiloba in a prescribed ratio. CONSTITUTION:Respective raw materials, i.e., Magnoliae cortex, Armeniacae Semen, Poncirus trifoliata and Rheum spp. and Angelica actiloba are blended in a prescribed ratio, e.g. (Magnoliae cortex : Armeniacae Semen : Poncirus trifoliata : Rheum spp. : Angelica actiloba = 1 : 1 : 1 : 2 : 1 preferably using the method of heat concentration in vacuo to readily obtain the objective cathartic, inducing natural evacuation entirely without a side effect even in a slight constipation or chronic constipation, etc., capable of activating peristaltic movement in the intestine and capable of entirely dissolving troubles due to constipation e.g. the induction of rough skin, eruptions, generation of gas due to intestinal clogging of dry stool, hot flash and sleeplessness caused by the generated gas, and induction of cancer caused by chronic stimulation to the intestinal mucous membrane due to accumulation of dry stool by using economic and readily available raw materials at a low cost.
For the healthy control outpatients, possibilities of acute or past chronic diseases were excluded. Moreover, we made sure that the healthy control subjects had not been hospitalized or taken vitamin-based substitutive drugs in the last 12 months, and proved normal in physical checkups and lab examinations.
<P>PROBLEM TO BE SOLVED: To provide a calcium L-threonate preparation whose elution with gastric juice can be prevented to enhance bioutility.  <P>SOLUTION: This oral administration composition containing the calcium L-threonate is characterized by containing a hydroxycarboxylic acid except L-threonic acid and L-ascorbic acid. The hydroxycarboxylic acid is preferably citric acid, lactic acid or malic acid. It is preferable that the content of the hydroxycarboxylic acid is 0.1 to 10 mass % based on the calcium L-threonate. The dosage form is preferably a tablet. It is preferable that the tablet is coated with an enteric coating. The enteric coating is preferably selected from gelatin, shellac, zein, ethyl cellulose, and methacrylic acid copolymers.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The present invention is related to a new metallo-beta lactamase (MBL) inhibitor of Formula I and an antibacterial composition comprising thereof for treating multidrug-resistant bacteria. Particularly, the present invention is related to (3,5-dichloro-4-(2-hydroxyethoxy)phenyl)boronic acid and (3,5-dichloro-4-(2-hydroxyethoxy)phenyl)boronic acid.The compound of Formula I according to present invention has inhibition activity to a broad-spectrum of metallo-beta-lactamases. By administering the MBL inhibitor of the present invention with beta-lactam antibiotic agents, the antibiotic agents can be protected from the degradation by the MBLs produced from a microorganism. Therefore, the time and scope of the activity of antibacterial agent can be prolonged or expanded. Some of bacteria which is resistant to antibacterial agent due to the presence of MBLs could be controlled by the composition of the present invention. Thus, the present invention is useful for treating or preventing the infection of antibiotic resistant bacteria.
PURPOSE: To obtain an emulsion-based skin cosmetic, comprising a pearl powder prepared by pulverizing a pearl formed in a saltwater and/or a limnetic shellfish and capable of protecting the skin from sunburn and imparting moistness without remaining white and causing stickiness. CONSTITUTION: This emulsion-based skin cosmetic is obtained by blending a pearl powder prepared by pulverizing a pearl formed in a saltwater and/or a limnetic shellfish (e.g. Pinctada fucata martensii Dunker, Pinctada margaritifera Linnaeus or Hyriopsis schlelii Martens) and has 1000-30000cP viscosity at 25 deg.C measured with a Brookfield type viscometer. Furthermore, the particle diameter of the pearl powder is preferably 50-200μm from aspects of dispersibility. The amount of the blended pearl powder is preferably 0.05-5.0wt.% in the total weight of the cosmetic. The coating treatment of the powder surface with an anionic or a nonionic surfactant may be carried out in order to further improve the dispersibility thereof.
COLIRIOBCN070660 Somatostatin 1mg/mL Eye drops, solution. One drop/eye administered twice a day.
Chronic pain may be complicated by mental disease. Some patients have behavioral disorders and occasionally harass the pain care providers. The COVID-19 pandemic caused significant stress for the general population. The stress of the pandemic may aggravate the psychological dysfunction in chronic pain patients.

This is a quantitative and qualitative analysis of prospective electronic and clinic diary data. It is an evaluation of incidents of pain clinic staff harassment; caused by patients, before and during the COVID pandemic. This is an analysis of incident causative factors, incident outcomes, systemic factors and lessons learned. The qualitative information of each incident is presented in a sensitive and careful format.
Sepsis is a worldwide problem. The World Health Organization estimates that around 49 million people suffer from sepsis each year. It is responsible for an unacceptable number of deaths, estimated at around 11 million. The severity of sepsis is not only related to the infection itself, but often to a too late diagnosis and an important heterogeneity in the management of patients. The identification of the pathogen responsible for sepsis is currently based on the positivity of bacteriological samples, particularly blood cultures. However, the diagnosis of bacteremia by blood cultures requires an average delay of 48 to 72 hours, which is not conducive to rapid adaptation of antibiotic therapy. The test proposed by OCEAN Dx offers the identification of a bacteremia in a few hours thanks to the recognition of the bacterial DNA in the patient's blood. The main objective of the study is to evaluate the performance of the rapid identification test for bacteremia offered by OCEAN Dx in comparison with a classical diagnostic strategy using blood cultures.
Two hours of case method education in COPD are given two times within 3 months to the general practitioners at nine primary health care centers. The education covers examination, including interpretation av spirometry, and treatment of patients with COPD. The learning outcomes are predefined and are the same in both arms. The same person will teach at both times of education.
PURPOSE: We conducted a randomized prospective trial (KLASS-07 trial) to compare laparoscopy-assisted distal gastrectomy (LADG) and totally laparoscopic distal gastrectomy (TLDG) for gastric cancer. In this interim report, we describe short-term results in terms of morbidity and mortality.
METHODS AND METHODS: The sample size was 442 participants. At the time of the interim analysis, 314 patients were enrolled and randomized. After excluding patients who did not undergo planned surgeries, we performed a modified per-protocol analysis of 151 and 145 patients in the LADG and TLDG groups, respectively.
RESULTS: The baseline characteristics, including comorbidity status, did not differ between the LADG and TLDG groups. Blood loss was somewhat higher in the LADG group, but statistical significance was not attained (76.76±72.63 vs. 62.91±65.68 mL; P=0.087). Neither the required transfusion level nor the operation or reconstruction time differed between the 2 groups. The mini-laparotomy incision in the LADG group was significantly longer than the extended umbilical incision required for specimen removal in the TLDG group (4.79±0.82 vs. 3.89±0.83 cm; P<0.001). There were no between-group differences in the time to solid food intake, hospital stay, pain score, or complications within 30 days postoperatively. No mortality was observed in either group.
CONCLUSIONS: Short-term morbidity and mortality rates did not differ between the LADG and TLDG groups. The KLASS-07 trial is currently underway.
TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03393182.
PrEP4T is an individualized TMSM-specific intervention consisting of online one-on-one sessions between a peer and a participant. PrEP4T has 9 hours of content: 6 1.5-hour sessions conducted weekly for 6 weeks. Participants will also receive access to the SOC materials.
Nifedipine is a drug belonging to a class of pharmacological agents known as the calcium channel blockers. Nifedipine is 3,5-pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester, C 17H 18N 2O 6, and has the structural formula: 

Nifedipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. It has a molecular weight of 346.3. Nifedipine GITS (Gastrointestinal Therapeutic System) tablet is formulated as a once-a-day controlled-release tablet for oral administration designed to deliver 30, 60, or 90 mg of nifedipine.

Inert ingredients in the formulations are: cellulose acetate; ferric oxide; hypromellose; magnesium stearate; polyethylene glycol; polyethylene oxide; potassium chloride; povidone; sodium chloride; titanium dioxide; propylene glycol and black iron oxide.

The USP Dissolution Test is pending.