anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants will be randomized to group 2: plant-based burger which contains no animal products. The Plant-based burger selected is ''Beyond Burger" (https://www.beyondmeat.com/products/the-beyond-burger/ ). Participants will be given two patties per day.
FIELD: pharmaceuticals.SUBSTANCE: invention relates to a composition to prevent or treat an allergic reaction. Said pharmaceutical composition for the prevention or treatment of an allergic reaction, comprising an extract from a plant of the Justicia genus or a fraction thereof as an active ingredient, where the plant of the Justicia genus is Justicia procumbens L., and the extract is an extract based on an organic solvent. Antiallergic agent. Use of an extract from a plant of the Justicia genus or its fraction to prevent or treat an allergic reaction. Method for preventing or treating an allergic reaction. Use of an extract from a plant of the Justicia genus or its fraction for the manufacture of a medication for the prevention or treatment of an allergic reaction.EFFECT: above described medications effectively suppress the secretion of IgE antibody and degranulation of mast cells and basophils, and also show an excellent anti-allergic effect, effectively prevent and treat allergic reactions.12 cl, 1 dwg, 14 tbl, 5 ex
The manufacturer recommended age-corrected end-tidal concentrations of desflurane in air should be set and achieved initially. Concentration of oxygen should be 50%.
<P>PROBLEM TO BE SOLVED: To provide a simple and speedy periodontal disease onset evaluation system rich in objectivity, a method for screening preventive/therapeutic agents of periodontal disease, an organ culture of a periodontal disease model, a set for screening preventive/therapeutic agents of periodontal disease, an animal of a periodontal disease onset model, etc.  <P>SOLUTION: A lower jaw is extracted from a mouse, and molar and incisor teeth are extracted under a stereoscope to collect alveolar bones of matched size. LPS or TLR2 ligand is added to an organ culture system of the alveolar bones and cultured for size days under the presence or absence of substances to be tested. After culturing, bone resorption activities are measured by determining the concentration of calcium in a culture supernatant. LPS is administered singly or with the substances to be tested to gingiva outside a molar tooth of the lower jaw of the mouse to measure the bone density of the alveolar bones under the stereoscope. It is understood by this screening that polymethoxy flavonoids contained in a shikuwasa extract etc. are effective for preventing/treating periodontal disease.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
This prospective clinical study was approved by Local ethical committee and written informed consent will be obtained before the trial starts. Criteria for selection of the patients was based on history and clinical findings characteristic of internal derangement. All these patients were initially treated with NSAIDS for 1 week and occlusal splints for 1 month had failed to respond to these conservative treatments. The patients with systemic problems which affect bone and joints,psychological problems ,history of maxillofacial fractures and orthognathic surgery were excluded from the study. A total of 60 patients with TMJ internal derangement with failed conservative management, were subjected to TMJ arthrocentesis. All arthrocentesis were performed by the same maxillofacial surgeon. Subjects were randomly allocated into two groups (30 cases in each group). Subjects in the group 1 received irrigation with Ringer solution and in the group 2 ,subjects underwent irrigation with Ringer solution with corticosteroid (Dexamethasone ) .Two examiners evaluated Temporomandibular disorder's signs ( mouth opening,click , crepitus and pain) before, one month and 6 months after arthrocentesis.
BACKGROUND: Drug-induced QT prolongation (diLQT) is a feared side effect that could expose susceptible individuals to fatal arrhythmias. The occurrence of diLQT is primarily attributed to unintended drug interactions with cardiac ion channels, notably the hERG (human ether-a-go-go-related gene) channels that generate the delayed-rectifier potassium current (IKr) and thereby regulate the late repolarization phase. There is an important interindividual susceptibility to develop diLQT, which is of unknown origin but can be reproduced in patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs). We aimed to investigate the dynamics of hERG channels in response to sotalol and to identify regulators of the susceptibility to developing diLQT.
METHODS: We measured electrophysiological activity and cellular distribution of hERG channels after hERG blocker treatment in iPS-CMs derived from patients with highest sensitivity (HS) or lowest sensitivity (LS) to sotalol administration in vivo (ie, on the basis of the measure of the maximal change in QT interval 3 hours after administration). Specific small interfering RNAs and CAVIN1-T2A-GFP adenovirus were used to manipulate CAVIN1 expression.
RESULTS: Whereas HS and LS iPS-CMs showed similar electrophysiological characteristics at baseline, the late repolarization phase was prolonged and IKr significantly decreased after exposure of HS iPS-CMs to low sotalol concentrations. IKr reduction was caused by a rapid translocation of hERG channel from the membrane to the cytoskeleton-associated fractions upon sotalol application. CAVIN1, essential for caveolae biogenesis, was 2× more highly expressed in HS iPS-CMs, and its knockdown by small interfering RNA reduced their sensitivity to sotalol. CAVIN1 overexpression in LS iPS-CMs using adenovirus showed reciprocal effects. We found that treatment with sotalol promoted translocation of the hERG channel from the plasma membrane to the cytoskeleton fractions in a process dependent on CAVIN1 (caveolae associated protein 1) expression. CAVIN1 silencing reduced the number of caveolae at the membrane and abrogated the translocation of hERG channel in sotalol-treated HS iPS-CMs. CAVIN1 also controlled cardiomyocyte responses to other hERG blockers, such as E4031, vandetanib, and clarithromycin.
CONCLUSIONS: Our study identifies unbridled turnover of the potassium channel hERG as a mechanism supporting the interindividual susceptibility underlying diLQT development and demonstrates how this phenomenon is finely tuned by CAVIN1.
Methods for controlling surface topography and binding reactivity in functionalized lipid layers, including in the form of liposomes, using pH-dependent processes. During direct cell-to-cell communication, lipids on the extracellular side of plasma membranes reorganize, and membrane associated communication-related molecules co-localize. At co-localization sites, sometimes identified as rafts, the local cell surface topography and reactivity are altered. Integration of these processes on nanometer-sized lipid vesicles used as drug delivery carriers would precisely control their interactions with diseased cells minimizing toxicities. Included are pH-dependent processes on functionalized lipid bilayers demonstrating reversible sharp changes in binding reactivity within a narrow pH window. Cholesterol enables tuning of the membrane reorganization to occur at pH values not necessarily close to the reported pKa's of the constituent titratable lipids. One illustrative function of the invention is to use liposomes to deliver bioactive agents to cancer or tumor cells and compositions of specific lipids that form liposomes to deliver a biologically active agent.
The present disclosure relates to methods of making, formulating and administering GLP-2 analogs.The present disclosure relates to methods of making, formulating and administering GLP-2 analogs. A valve assembly has a housing defining a flow passage therethrough. A first flapper is disposed in the housing. A first sleeve retains the flapper in an open position. At least one lock ring holds the first sleeve in a first position. A tripping ball engages a plurality of disconnected bodies in the sleeve and a force is applied to move the first sleeve from the first to a second position.
A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugages are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection of prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NEGP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.
BACKGROUND: Ubiquitination plays a key role in various cancers, and F-box and WD repeat domain containing 7 (FBW7) is a tumor suppressor that targets several cancer-causing proteins for ubiquitination. This paper set out to pinpoint the role of FBW7 in hepatocellular carcinoma (HCC).
METHODS: The target proteins of FBW7 and the expression of hromodomain helicase DNA binding protein 3 (CHD3) were analyzed in liver HCC (LIHC) samples using the BioSignal Data website. The effects of CHD3 and FBW7 on HCC cell viability, migration, invasion and stemness were investigated through cell counting kit (CCK)-8, wound healing, transwell and sphere formation assays. Detection on CHD3 and FBW7 expressions as well as their relationship was performed employing quantitative reverse transcription-polymerase chain reaction (qRT-PCR), immunoprecipitation, ubiquitination and western blot analyses.
RESULTS: The prediction of Ubibrowser revealed CHD3 as a target protein of FBW7. The data of starBase exhibited a higher expression level of CHD3 in LIHC samples relative to normal samples. CHD3 was upregulated in HCC cells. CHD3 knockdown inhibited HCC cell proliferation, migration, invasion, stemness and oxaliplatin sensitivity. FBW7 targeted CHD3 for ubiquitination. FBW7 overexpression restrained HCC cell migration, invasion and stemness, and attenuated the effects of overexpressed CHD3 on promoting migration, invasion, stemness and oxaliplatin resistance in HCC cells.
CONCLUSION: FBW7 overexpression suppresses HCC cell metastasis, stemness and oxaliplatin resistance via targeting CHD3 for ubiquitylation and degradation.
The invention provides application of evodiamine, mouthwash and a preparation method of the mouthwash, and belongs to the field of medicines. The application of the evodiamine comprises the following steps: the application of evodiamine in preparing a medicament for preventing or treating periodontitis; the application of evodiamine in preparing an inhibitor for periodontal ligament stem cell inflammatory reaction; application of evodiamine in preparing osteoclast differentiation and maturation inhibitor is provided. The mouthwash for treating periodontitis comprises the following raw materials: evodiamine, a surfactant, a hydrophilic dispersant and a lipophilic dispersant. The preparation method of the mouthwash comprises the following steps: mixing and dispersing evodiamine, a surfactant, a hydrophilic dispersant and a lipophilic dispersant in water, and stirring at 80-85 ℃. The invention provides a new idea for preventing or treating periodontitis and also expands the application range of evodiamine. In addition, the mouth wash prepared from the evodiamine can effectively prevent and treat periodontitis.
The actions of epinephrine resemble the effects of stimulation of adrenergic nerves. To a variable degree it acts on both alpha and beta receptor sites of sympathetic effector cells. Its most prominent actions are on the beta receptors of the heart, vascular and other smooth muscle. When given by rapid intravenous injection, it produces a rapid rise in blood pressure, mainly systolic, by (1) direct stimulation of cardiac muscle which increases the strength of ventricular contraction, (2) increasing the heart rate and (3) constriction of the arterioles in the skin, mucosa and splanchnic areas of the circulation.

When given by slow intravenous injection, epinephrine usually produces only a moderate rise in systolic and a fall in diastolic pressure. Although some increase in pulse pressure occurs, there is usually no great elevation in mean blood pressure. Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors.

Total peripheral resistance decreases by action of epinephrine on beta receptors of the skeletal muscle vasculature and blood flow is thereby enhanced. Usually this vasodilator effect of the drug on the circulation predominates so that the modest rise in systolic pressure which follows slow injection or absorption is mainly the result of direct cardiac stimulation and increase in cardiac output. In some instances peripheral resistance is not altered or may even rise owing to a greater ratio of alpha to beta activity in different vascular areas.

Epinephrine relaxes the smooth muscles of the bronchi and iris and is a physiologic antagonist of histamine. The drug also produces an increase in blood sugar and glycogenolysis in the liver.

Intravenous injection produces an immediate and intensified response. Following intravenous injection epinephrine disappears rapidly from the blood stream. Epinephrine is rapidly inactivated in the body and is degraded by enzymes in the liver and other tissues. The larger portion of injected doses is excreted in the urine as inactivated compounds and the remainder either partly unchanged or conjugated.

The drug becomes fixed in the tissues and is inactivated chiefly by enzymatic transformation to metanephrine or normetanephrine either of which is subsequently conjugated and excreted in the urine in the form of sulfates and glucuronides. Either sequence results in the formation of 3-methoxy-4-hydroxy-mandelic acid (vanillyl-mandelic acid: VMA) which also is detectable in the urine.

Sodium chloride added to render the solution isotonic for injection of the active ingredient is present in amounts insufficient to affect serum electrolyte balance of sodium (Na+) and chloride (Cl–) ions.
The system was filled with liquid by connecting the tap to the UK. The faucet was turned off, sterile gauze was placed around the umbilical clamp and lifted out of the sterile area. The other assistant held the cord with a clamp and lifted it vertically up and away from the sterile field. The cord and its surroundings were prepared with an antiseptic solution and covered. The umbilicus was tied with a single knot and the cord was cut horizontally with a scalpel. Bleeding on the surface of the cord was wiped with sterile gauze. The cord stump was grasped with toothed forceps close to the vessel to be catheterized. The catheter was placed in the lumen of the vessel and advanced in the vessel. When the catheter exceeded 5 cm, it was aspirated to confirm the intraluminal position. The blood that came with an average of 0.5 ml bolus solution was cleaned and the catheter was fixed.
Sham tACS will be also applied twice daily for 5 days.The parameters of tACS electrodes numbers, locations, and current duration are all the same with active tACS. But sham tACS begin with a fade in over 3s to the peak, followed immediately by no current stimulation for 20 minutes and a fade out of 3s.
FIELD: medicine.SUBSTANCE: composition contains celecoxib in an amount of less than 400 mg, preferably 240 mg, or 180 mg, or 120 mg, medium-chain glyceride in amount of 5 to 75 wt. %, a solubilising agent in amount of 10 to 70 wt. %, a polar solvent in amount of 20 to 80 wt. % and a pharmaceutically acceptable excipient. Celecoxib composition has average size of oil drops of not more than 500 nm. According to the invention, the liquid composition of celecoxib shows no precipitation when exposed to gastric juice obtained by simulating starvation (FaSSGF), at pH 2.0, temperature 37 ± 0.5 °C and while stirring with frequency of 50 rpm for at least 60 minutes. Liquid composition of celecoxib under the invention a) releases at least 70 % celecoxib for a period of time of 10 min or b) releases at least 80 % celecoxib for period of 15 minutes, in 900 ml 0.01 n. solution of HCl with 0.5 % sodium lauryl sulphate, when tested in apparatus USP type 2 with weights at 50 rpm and temperature of 37 °C.EFFECT: present invention relates to an oral liquid pharmaceutical composition of celecoxib for treating human pain.31 cl, 5 dwg, 5 tbl, 8 ex
In 2010, Italian urologist Dr Bocciardi carried out the first clinical practice of separation and resection of the prostate via the vesicorectal fossa, and this new surgical procedure was called Retzius-sparing Robotic Assisted Radical Prostatectomy (RS-RARP). In recent years, the posterior approach extrafascial technique of RS-RARP which has been used to widely resect the prostate and its surrounding fascia and neurovascular bundles, compared with RS-RARP, has been proposed to provide more complete resection of the tumour and reduce the rate of positive margins. The patients are included into the posterior approach extrafascial technique group who undergo the posterior approach extrafascial technique of RS-RARP.
LPV was first introduced in the intensive care units but has been recently adopted in the operating rooms. Obstructive sleep apnea (OSA) is a widely prevalent condition in obese patients and requires special attention in the operating room. Screening for OSA risk in surgical patients is a common practice. The STOP-BANG questionnaire is a common screening tool for OSA (Snoring, Tiredness, Observed apnea, high blood Pressure, BMI, Age, Neck circumference, and male Gender). The American Society of Anesthesiologists practice guidelines for the perioperative management of patients with OSA do not recommend any specific ventilation strategy to prevent PPCs in this population. To the knowledge of the investigators, the association between intraoperative ventilation strategies and PPCs in laparoscopic bariatric surgery patients, who have a high STOP-BANG score, has not been adequately investigated. The investigators propose a retrospective chart review of patients, 18 years of age and older, who underwent laparoscopic bariatric surgery, in reverse Trendelenburg position, using pressure controlled ventilation (PCV/PCV-VG) at the Ohio State University Wexner Medical Center, between January 01, 2012 and November 22, 2016, to determine whether intraoperative driving pressure is a predictor of postoperative pulmonary complications. No procedures will be done for the sake of conducting this study except for a retrospective review of patient charts. Preoperative and intraoperative variables will be collected to determine their predictive value of postoperative complications. No risks to the patients' health or well being are anticipated due to the conduct of the proposed study. No immediate benefits to the patients from whom data was collected is anticipated either. Results obtained from this study may provide valuable information on the preferred ventilation strategies in the operating room for future patients who have a high risk of postoperative lung complications.
Through convenience sampling, 68 graduate students in an occupational therapy program were recruited to participate. The quasi-experimental study was conducted at Russell Sage College, in Troy, New York, with approval from the International Review Board Inclusion criteria were male and female first and second-year students, ages 19-34, enrolled in Functional Anatomy and Kinesiology or Physical Agent Modalities. The data was collected during lab practicals in December 2021 and June 2023. Forty-three students signed consent forms to participate. Students sign up for 20-minute time slots in pairs for the practical exam. Each student randomly selects confidential assessment cards and takes turns independently completing their assignment. Each practical contains a grading rubric, and a score of 80 is required to pass. Students either had one private room when an examiner during the practical, and either it was quiet or low 60 bpm music played in the background. Pre and post-outcome measures evaluated each student's state, trait, test anxiety, blood pressure, and heart rate outside the assessment room. State and trait anxiety was measured using the State-Trait Anxiety Inventory for Adults™ by Charles D. Spielberger and the Test Anxiety Inventory by Charles D. Spielberger \& Associates. State-Trait Anxiety is cited in over 20,000 articles and is the primary assessment used most often for individuals susceptible to anxiety. The reliability of the State-Trait Anxiety is .86 - .95, and substantial evidence confirms its validity. Mean S-anxiety .59, T- T-anxiety .57 college students of both sexes. The Test Anxiety Inventory measures individual situational anxiety of symptom frequency throughout an exam, like apprehension and nervousness. Remote online survey licenses were purchased to administer the State-Trait Anxiety Adult and Test Anxiety Inventory on each student's laptop. Mind Garden's Transform System collected raw scaled scores. The research team recorded blood pressure and heart rate with the digital Blood Pressure monitor with an upper arm cuff.
Patients with locally advanced colon cancer who met the inclusion criteria received two cycles of Capecitabine and Oxaliplatin （Capox） regimen chemotherapy and were evaluated by enhanced CT. Patients with more than 20% regression of maximum diameter of colon tumor in enhanced CT image will be randomly assigned to the Enhancement regimen of combined Anti-PD-L1 monoclonal antibody and continued with two more cycles of Capox chemotherapy along with the reduced dosage of Anti-PD-L1 monoclonal antibody. Then, these patients will receive curative surgery for colon cancer.
The invention discloses a dissolution method of tablets containing (+)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl) ethylamine N-acetyl-L-leucine salt. According to the technical scheme, a lauryl sodium sulfate aqueous solution with the concentration being 0.1%-1.0% is used as dissolution media, the dissolution temperature is 37 DEG C, a paddle method is used by 50-75 r/min, ultraviolet spectrophotometry is adopted, and the absorption degree is determined at 230 nm. Through the method, the dissolution behavior and the preparation mass of a reaction preparation can be reflected objectively. Meanwhile, the invention discloses a preparation technology of the tablets. The preparation technology includes the steps of sieving, mixing, dry granulating, total blending, tabletting, coating and packaging for being put in storage. The sticking problem of the tablets and the problem of being poor in content uniformity in the production process can be well solved.