anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Internal herniation is a well-known complication of laparoscopic Roux-en-Y gastric bypass (L-RYGB). The aim of this study was to evaluate smoking as an independent risk factor for internal herniation after L-RYGB.
MATERIALS AND METHODS: This study was performed as an exploratory post hoc analysis of data from a previous published randomized controlled trial (RCT) designed to compare closure and non-closure of mesenteric defects in patients undergoing L-RYGB. The primary outcome of this study was to assess the significance of smoking as a risk factor for internal herniation after L-RYGB. Secondary outcome was early postoperative complications defined as Clavien-Dindo grade ≥ 2.
RESULTS: Four hundred one patients were available for post hoc analysis. The risk of internal herniation was significantly higher among patients who were smoking preoperatively (hazard ratio (HR) 2.4, 95% confidence interval (c.i.) 1.3 to 4.5; p = 0.005). This result persisted after adjusting for other patient characteristics (HR 2.2, 1.2 to 4.2; p = 0.016). 6.0% of the patients had postoperative complications within the first 30 days. 4.9% of these patients were smoking and 6.3% were not smoking, p = 0.657. 11.0% of the patients underwent surgery due to internal herniation by 5 years after the primary procedure.
CONCLUSION: Smoking is a significant risk factor for internal herniation but did not increase risk for 30 days postoperative complications.
INTRODUCTION: Laparoscopic liver surgery has advanced significantly, offering benefits, such as reduced intraoperative complications and quicker recovery. However, complex laparoscopic hepatectomy (CLH) is technically demanding, requiring skilled surgeons. This study aims to share technical aspects, insightful tips, and outcomes of CLH at our center, focusing on the safety and learning curve.
METHODS: We reviewed all patients undergoing liver resection at our center from July 2017 to December 2023, focusing on those who underwent CLH. Of 135 laparoscopic liver resections, 63 (46.7%) were CLH. The learning curve of CLH was also assessed through linear and piecewise regression analyses considering the operation time and intraoperative blood loss.
RESULTS: Postoperative complications occurred only in 4.8% of patients, with a 90-day mortality rate of 3.2%. The mean operation time and blood loss significantly decreased after the first 20 operations, marking the learning curve's optimal cut-off. Significant improvements in R0 resection (p = 0.024) and 90-day mortality (p = 0.035) were noted beyond the learning curve threshold.
CONCLUSION: CLH is a safe and effective approach, with a relatively short learning curve of 20 operations. Future large-scale studies should further investigate the impact of surgical experience on CLH outcomes to establish guidelines for training programs.
FIELD: medicine. ^ SUBSTANCE: invention concerns artificial physiological saline solution for washing of eyes and nose and the method of its manufacturing. The declared solution has the size of reaction of active hydrogen from 0.01 to 1, pH from 6.0 to 7.7 and osmotic pressure from 280 mOsm/l to 305 mOsm/l. The given solution effectively eliminates active oxygen, suppresses chemotactic activity and thus does not possess irritating action on processed organs. ^ EFFECT: method of obtaining of the declared solution consists in adjustment of properties of the electrolytically restored water in such a manner that the size of reaction of active hydrogen becomes from 0,01 to 1, pH becomes from 6,0 to 7,7 and osmotic pressure becomes from 280 mOsm/l to 305 mOsm/l. ^ 9 cl, 6 ex, 1 tbl, 1 dwg
PURPOSE:To remove a smell and to obtain a readily drinkable drink of Houttuynia cordata, having excellent medicinal effects, by putting raw Houttuynia cordata cut into a proper size into an aeration tank, deodorizing the raw Houttuynia cordata by using a H2 gas, steam, O2 gas, etc., to give a medium, inoculating yeast to the medium and fermenting. CONSTITUTION:Collected raw Houttuynia cordata is washed with water, stems and roots are put together, cut into about 5-6cm length and stored in an aeration tank. Then a H2 gas is introduced into the aeration tank, a characteristic smell of Houttuynia cordata is removed, the deodorized Houttuynia cordata is packed into a container such as glass bottle and blended with a given amount of sugar. Then the Houttuynia cordata containing the saccharide component is used as a medium, inoculated with yeast, fermented and an aging period of about 72 hours is set to give a viscous aqueous solution. The aqueous solution is a drink of Houttuynia cordata having no unpleasant smell at all without damaging medicinal components of Houttuynia cordata. Raw Houttuynia cordata can be deodorized with steam or an O2 gas besides a H2 gas.
Subject will receive either 5 or 10 mg of oral nebivolol daily. Dose will be determined by control of blood pressure.
Background: Recurrence is a key outcome to evaluate the treatment effect of differentiated thyroid carcinoma (DTC). However, no consistent definition of recurrence is available in current literature or international guidelines. Therefore, the primary aim of this systematic review was to delineate the definitions of recurrence of DTC, categorized by total thyroidectomy with radioactive iodine ablation (RAI), total thyroidectomy without RAI and lobectomy, to assess if there is a generally accepted definition among these categories. Methods: This study adhered to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. In December 2023, a systematic literature search in MEDLINE and EMBASE was performed for studies reporting on the recurrence of DTC, from January 2018 to December 2023. Studies that did not provide a definition were excluded. Primary outcome was the definition of recurrence of DTC. Secondary outcome was whether studies differentiated between recurrence and persistent disease. Two independent investigators screened the titles and abstracts, followed by full-text assessment and data extraction. The study protocol was registered in PROSPERO, CRD42021291753. Results: In total, 1450 studies were identified. Seventy studies met the inclusion criteria, including 69 retrospective studies and 1 randomised controlled trial (RCT). Median number of patients in the included studies was 438 (range 25-2297). In total, 17 studies (24.3%) reported on lobectomy, 4 studies (5.7%) on total thyroidectomy without RAI, and 49 studies (70.0%) with RAI. All studies defined recurrence using one or a combination of four diagnostic modalities cytology/pathology, imaging studies, thyroglobulin (-antibodies), and a predetermined minimum tumor-free time span. The most common definition of recurrence following lobectomy was cytology/pathology-proven recurrence (47.1% of this subgroup), following total thyroidectomy with RAI was cytology/pathology-proven recurrence and/or anomalies detected on imaging studies (22.4% of this subgroup). No consistent definition was found following total thyroidectomy without RAI. Nine studies (12.9%) differentiated between recurrence and persistent disease. Conclusion: Our main finding is that there is no universally accepted definition for recurrence of DTC in the current studies across any of the treatment categories. The findings of this study will provide the basis for a future, international Delphi-based proposal to establish a universally accepted definition of recurrence of DTC. A uniform definition could facilitate global discussion and enhance the assessment of treatment outcomes regarding recurrence of DTC.
INTRODUCTION: Limited studies investigate bariatric surgery's role in improving UI status among Asians, specifically Middle Eastern Asian women. The aim of this study is to investigate the effect of bariatric surgery on the three most prevalent urine incontinence (UI).We also reviewed the current literature exploring the studies performed in Asian countries.
MATERIALS AND METHODS: A total of 77 women out of 200 who had UI and indications for bariatric surgery completed demographic information and the questionnaire (QUID) prior to surgery and 6 months after the surgery. For statistical analysis, the Mann-Whitney U test, Wilcoxon test, and Friedman test were utilized. We also performed a literature review with the aim of investigating studies performed in Asian countries.
RESULTS: Among the initial analysis of 200 participants, 50.5% reported UI symptoms before surgery. The average weight loss was 29 kg, with a standard deviation of 7 kg. The mean BMI dropped 11.2 kg/m2, and the standard deviation was 2.5 after weight loss. Post-surgery, significant reductions in UI scores were observed across all severity levels, with a notable 44% achieving complete symptom resolution, indicating a substantial decrease in urinary incontinence. Stress, urine incontinence, and mixed urine incontinence symptoms had improved in 75%, 71%, and 30% of women, respectively. Notably, age and gynecological history were identified as critical factors influencing the extent of UI improvement.
CONCLUSION: This study reveals significant improvements in urinary incontinence scores, with age and gynecological history playing pivotal roles in UI improvement.
The role of gut microbiota in health and disease is being thoroughly examined in various contexts, with a specific focus on the bacterial fraction due to its significant abundance. However, despite their lower abundance, viruses within the gut microbiota are gaining recognition for their crucial role in shaping the structure and function of the intestinal microbiota, with significant effects on the host as a whole, particularly the immune system. Similarly, environmental factors such as stress are key in modulating the host immune system, which in turn influences the composition of the gut virome and neurological functions through the bidirectional communication of the gut-brain axis. In this context, alterations in the host immune system due to stress and/or dysbiosis of the gut virome are critical factors in the development of both infectious and noninfectious diseases. The molecular mechanisms and correlation patterns between microbial species are not yet fully understood. This literature review seeks to explore the interconnected relationship between stress and the gut virome, with a focus on how this interaction is influenced by the host's immune system. We also discuss how disturbances in this finely balanced system can lead to the onset and/or progression of diseases.
Studies in older children and adults have found that IQ (intelligence quotient) in individuals with Turner syndrome (TS) and the general population are similar. However, many individuals with TS have a nonverbal learning disability which may cause problems with imagining and working with objects in space (for example: building blocks, working puzzles, copying designs, driving a car) as well as problems in planning, paying attention, and getting along with people their own age. Studies of brain structure have found changes in the size and function of specific areas of the brain that are involved in these nonverbal processes. However, there are no data published on brain structure or function in girls with Turner Syndrome in the first few years of life when brains are learning and growing most rapidly.

In a recent study, very young, short girls with Turner Syndrome (TS)(averaging 2 years in age) were treated with Growth Hormone (GH) and almost reached an average height after 2 years. The risks of GH for the young girls in that study appeared to be the same as those for older girls. Therefore, it is now recommended that GH therapy be considered as soon as a child with TS has growth failure. Growth failure often occurs during infancy; therefore, more children with TS are now receiving GH therapy as young as 12 months of age. In this study, the investigators wish to start understanding what effect GH has on learning and brain growth when given between the ages of 12 and 24 months. In this study, the girls with TS will have developmental studies, a physical examination, magnetic resonance imaging (MRI), and blood drawn at one and two years of age. Some of the girls in this study will receive GH from 12 until 24 months of life, while others will not. Brain growth and development will be compared between those who have been treated with GH and those who have not. This is a pilot study in which the investigators will gather data to design a larger study that can answer these questions.
Patients receive white button mushroom extract PO twice daily on days 1-28. Treatment repeats every 4 weeks in the absence of disease progression or unacceptable toxicity.
The study enroll a large population of approximately 252467 participants. This epidemiology study of diabetes and cancer risk is an expansion study which would include estimation of cancer rate among KPNC members with or without diabetes and the relative risks of cancers associated with a diagnosis of diabetes. The study included diabetes participants who were KPNC members between 1997 and 2011. It also included a subset of participants who took the 1996/7 diabetes survey and Member Health Survey (MHS) in 1993, 1999, 2001 or 2003.

This multi-center trial was conducted in the United States of America. The overall time to participate in this study was approximately 15.5 years. The participants were followed-up from January 1, 1997 up to December 31, 2011.
Colouring materials in powder form for application to the hair consist of colour particles coated with a substance which constitutes a fixative whereby the particles tend to adhere to the hair, the coating being so thinly applied as to prevent the particles from clogging together and to permit free dispersion of the particles when they are applied to the hair.  The coating material may be stearic acid, resins, both natural and synthetic, e.g. colophony resin, fats, stearyl, lauryl or cetyl alcohols, or silicones.  The colour particles may be pigments, metallic powders, e.g. aluminium (which may be anodized and coloured), fluorescent materials and mica.  The particles may be coated with 1 to 4 per cent. coating material.  The coated particles may be mixed with flock.  Specifications 477,451, 572,635, 652,915, 665,709, 674,407 and 721,045 are referred to.
PURPOSE: A monoclonal antibody which recognizes Muc1 protein and a diagnosis kit for human breast cancer or ovarian cancer containing the same are provided. CONSTITUTION: A monoclonal antibody which recognizes Muc1(mucin 1) recognizes 138-157th amino acid from amino terminal of human Muc1 antigen having an amino acid of seqeunce number 1. A diagnosis kit for human breast cancer or ovarian cancer contains the monoclonal antibody. The monoclonal antibody has a strip form. A method for diagnosing human breast cancer or ovarian cancer in a biological sample: a step of contacting the biological sample with Muc1 monoclonal antibody to obtain an immunological complex; a step of detecting the immunological complex. The biological sample is human urine.
The invention discloses a hydrogel patch for relieving seasonal eye irritation. The patch comprises (1) a backing layer, (2) an adhesive layer (polymeric hydrogel) and (3) an isolating layer coated with ultraviolet cured silicone. The eye patch is formed by taking the adhesive layer as a carrier and realizing compatibility among the adhesive layer, a water-retaining agent, a penetration enhancer, a tackifier and inflammation diminishing medicines, and active ingredients are obtained. A spatial meshed structure is formed by virtue of a three-dimensional meshed high polymer stereoscopic structure; and according to the affinity of liquid and high polymer network, the effective liquid medium is dispersed and inlaid into a three-dimensional framework, the liquidity is lost, and long-acting, sustained and controlled-release and targeted drug delivery can be realized. Moreover, the eye patch has high drug loading capacity, high breathability, adhesiveness and moisture retention capacity, and the active ingredients are easy to absorb. According to a breathable hydrophilic gel matrix, the skin cuticala hydration and biocompatibility problems can be solved. The hydrogel patch is high in biocompatibility, small in toxic and side effect, convenient to carry and easy to use, difficultly generates irritation and is a high-efficiency cutaneous penetration patch for relieving seasonal eye irritation in the figures.
BACKGROUND: Obesity has a detrimental impact on individuals, communities, and healthcare systems. Trefoil factor 3 is a secretory protein involved in metabolic processes related to weight regulation. However, its relation with obesity is not fully understood.
OBJECTIVE: We aimed to assess the serum trefoil factor 3 level and to immunohistochemical detect the leptin in obese patients to evaluate their relation to obesity pathogenesis.
METHODS: As a case-control study, we enrolled 83 non-obese persons as a control group with a BMI (18.5-24.9) and 83 obese persons as a patient group with a BMI > 30. All the study volunteers are subjected to anthropometric measurements, glucose, and lipid profile analysis by colorimetric methods. Serum trefoil factor 3 level was estimated by ELISA and leptin hormone was detected immunohistochemically in the blood using cell block technique.
RESULTS: ROC curve analysis for TFF3 showed a good relation with obesity with an AUC of 0.891 and a cut-off value of > 96 ng/ml. There was a significant positive correlation between TFF3 and fasting blood sugar, total cholesterol, and triglycerides. The logistic regression analysis showed that TFF3 is a good risk factor for obesity incidence [p = 0.008; OR = 1.117; (95 % CI): 1.029-1.213]. This was confirmed by multiple linear regression that gave an equation for the possibility of predicting BMI using several factors including TFF3 [BMI = 0.821 + 0.051 × TFF3 + 0.044 × FBS + 0.85 × TC]. The more surprising was the ability of the immunohistochemistry cell block technique to detect leptin antigens associated with an obese person blood not only adipose tissue or serum.
CONCLUSION: Leptin hormone and TFF3 could be good indicators for obesity incidence. Further research with a larger sample size and in different populations could completely approve our results.
Hyperuricemia (HUA), a metabolic disease caused by excessive production or decreased excretion of uric acid (UA), has been reported to be closely associated with a variety of UA transporters. Clerodendranthus spicatus (C. spicatus) is an herbal widely used in China for the treatment of HUA. However, the mechanism has not been clarified. Here, the rat model of HUA was induced via 10% fructose. The levels of biochemical indicators, including UA, xanthine oxidase (XOD), adenosine deaminase (ADA), blood urea nitrogen (BUN), and creatinine (Cre), were measured. Western blotting was applied to explore its effect on renal UA transporters, such as urate transporter1 (URAT1), glucose transporter 9 (GLUT9), and ATP-binding cassette super-family G member 2 (ABCG2). Furthermore, the effect of C. spicatus on plasma metabolites was identified by metabolomics. Our results showed that C. spicatus could significantly reduce the serum levels of UA, XOD, ADA and Cre, and improve the renal pathological changes in HUA rats. Meanwhile, C. spicatus significantly inhibited the expression of URAT1 and GLUT9, while increased the expression of ABCG2 in a dose-dependent manner. Metabolomics showed that 13 components, including 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PE, Tyr-Leu and N-cis-15-Tetracosenoyl-C18-sphingosine, were identified as potential biomarkers for the UA-lowering effect of C. spicatus. In addition, pathway enrichment analysis revealed that arginine biosynthesis, biosynthesis of amino acids, pyrimidine metabolism and other metabolic pathways might be involved in the protection of C. spicatus against HUA. This study is the first to explore the mechanism of anti-HUA of C. spicatus through molecular biology and metabolomics analysis, which provides new ideas for the treatment of HUA.
A surgical product supply system includes a cart having a first compartment and a second compartment. The first compartment has first, second, third and fourth walls. The first and second walls are constructed of radio-reflective material and the third and fourth walls are constructed of a radio-absorptive material. The first compartment has a first storage area. A first RFID antenna array is attached to the first wall and is positioned within the first storage area. The first RFID antenna array includes a first plurality of RFID antennas. A second RFID antenna array is attached to the second wall and is positioned within the first storage area. The second RFID antenna array includes a second plurality of RFID antennas. The first RFID antenna is offset relative to the second RFID antenna such that opposing central axes of the first and second RFID antennas are not colinear.
The present invention discloses a method for preparing Gongjiule medicinal wine for treating trachitis. The medicinal wine is prepared from more than 20 kinds of Chinese herbal medicine, such as Chinese caterpillar fungus, red jujube, hemlock parsley, barbary wolfberry fruit, radix glycyrrhiza, pawpaw, cassia bark, incised notoptetygium rhizome or root, prepared rhizome of rehmannia, milkvetch root, yam, cornel, dried tangerine peel, anise, shinyleaf pricklyash root, suberect spatholobus, cherokee rose root, angelica, white poria, bulbus fritilariae, etc. The Chinese herbal medicine is stir-fried with honey, and a proper amount of distillated rice wine is added to a mixture of the Chinese herbal medicine and the honey; then, a mixture of the Chinese herbal medicine, the honey and the rice wine is put into a vat, and the vat is sealed so as to obtain the medicinal wine. The medicinal wine has the functions of cough alleviation, asthma relief, channel dredging, bacteriostasis, inflammation relief, hematid, hematochrome and leucocyte increase, breathing function improvement and cure of trachitis. In addition, the medicinal wine also has curative effects on diabetes, rheumatism, bone diseases, internal injury and static blood. The medicinal wine can be taken orally and smeared externally, and the medicinal wine is wide-purpose medicinal wine.
The invention relates to a hair tonic and hair promotion agent for rubbing scalp and hairs to lead hairs to grow strong, preventing hairs from being lost, and promoting hairs to grow. The main compositions of the hair tonic and hair promotion agent comprise residual liquid of alfalfa deproteinising, quinine sulfate, rose water, ceraniol, benzyl carbinol, lauryl alcohol, linalool, eugenol, alcohol and water. The relative hair tonic and hair promotion agent can be made by the main compositions through special technique. The main composition of the invention is residual liquid of alfalfa deproteinising which has low cost and easy availability, and is beneficial for lowering cost. Alfalfa is a natural edible plant, and deproteinising residual liquid of alfalfa which is used as effective composition is safe to human bodies. The invention has excellent hair tonic and hair promotion effect, which has the effects of leading hairs to grow strong, preventing hairs from being lost, and promoting hairs to grow, and the invention has quick results.
A group B adenovirus comprising a sequence of formula 5'ITR-B1-BA-B2-BX-BB-BY-B3-3'ITR, wherein: By comprises a sequence -G1-G2n-G3m-G4p-G5q. G1 is a first transgene. G2 is a second transgene. G3 is a third transgene. G4 is a fourth transgene. G5 is a fifth transgene and IL-15 is encoded as a transgene in at least one of said locations, and characterised in that BY also encodes a polypeptide comprising the sushi domain of IL-15R alpha.