anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcription3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activating T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen­presenting cells with decreased Stat3 function to a patient. The invention further relates to methods for stimulating dendritic cell differentiation.
The number of visits to emergency departments (ED) has been rising steadily for both adult and pediatric patients over the past decades. resulting in an increase in waiting and care times. Each ED manages a wide variety of pathologies ranging from a simple general consultation to a life-threatening emergency. However, overcrowding in the ED as well as difficulties in monitoring patients waiting for clinical examination, can endanger patient safety. Patients require prioritization and triaging as soon as they reach the ED and cannot be seen purely in the order of arrival. An ideal triage system should be able to identify those who require immediate care (high-level emergency) from those who can wait or those who will not require emergency care (intermediate- to low-level emergency). This triage is mostly carried out by a nurse at the triage zone who must quickly identify high-emergency patients requiring immediate care and organize their care pathway. The triage nurse uses a decision support tool known as a triage tool.

In France, there is no gold standard in pediatric triage and each hospital uses their own "home-made" triage system. In 2000, the PED of the University Hospital of Nice (France) created a 5-level pediatric triage tool - the pediaTRI - based on clinical items of inspection, interview, and analysis of vital signs. In a pediatric ED (PED) setting, a high-level emergency corresponds to a child presenting an immediate life-threatening risk that could lead to cardio-respiratory arrest or a related emergency, and thus requires rapid intervention. These patients, for whom a Level 1 or 2 is usually assigned by commonly used pediatric triage tools, can also be screened using warning scores that are predictive of clinical deterioration within 24 hours after visiting the PED. Among them, the Pediatric Early Warning System (PEWS) system, created in 2001, is considered to be efficient, easy to use, and reliable. The PEWS system is based on three main components each given a 3-point rating as follows: (a) behavior and early signs of shock, recognizable and assessable by the parents; (b) skin tone and capillary refill time to assess the cardiovascular system; (c) and respiratory rate and oxygen dependence to assess the respiratory system. According to the literature, the optimal cutoff level to calculate the sensitivity and specificity for admission to an ICU, defined as a high-level emergency, is ≥ 4/9. Vitals signs used to calculate the PEWS are usually collected by the nurse at the triage zone. However, new technology such as mobile application may be also used to capture those vital signs (i-Virtual).

Since the parameters of the PEWS system may be evaluate by parents using the application, the investigators want to analyze their ability to assess the level of severity of their children by scoring PEWS in our pediatric emergency department using the mobile application Caducy® (i-Virtual).
Proximal humerus fractures in children are relatively uncommon and most of them do not require surgical treatment due to the healing potential in children. The management of proximal humerus fractures in children subsequently underwent a major change with the introduction of surgical metal rod nailing. Despite that, the best criteria for choosing between these two treatment options are still not agreed upon. To date, the clinical benefits and harms of surgical intervention in proximal humerus fractures in children remain debatable. The investigators hypothesised that the outcomes of the non-operative management for proximal humerus fractures to remain excellent due to the healing ability of children. If good clinical results are achieved in our patient cohort, the investigators would like to send out the message that non-operative treatment for proximal humerus fractures in children should be recommended, even for those severely displaced fractures.

With Caldicott approval, the investigators can review the X-rays performed in children and adolescents, aged from 10 to 18-year-old in NHS Tayside, from 2008 to 2015. By using the Picture Archiving and Communication System (PACS), the investigators will be able to identify the cohort of patients who had proximal humerus fractures from the X-rays. The Caldicott approval also allowed the investigators to obtain clinical communication from Clinical Portal. The identified potential participants will be approached by the paediatric orthopaedic team. An invitation letter, a participant information sheet and questionnaire, based on UEFI will be sent to all potential participants by the care team via post. If no response within 2 weeks, the investigators will send out 1 further reminder. If no further response, the patient will be excluded from the study.
PURPOSE:To obtain the titled growth promoting adjuvant water, consisting of silver ion water at a specific pH or below and ion concentration within a specific range, having soil improvement, control of pathogenic germs, etc., as well as growth of symbiotic germs, growth and maturing promotion, etc., of fruits and useful as growth promoting adjuvant water for cultivating plants, e.g. field crops, etc. CONSTITUTION:Growth promoting adjuvant water, consisting of Ag ion water having <=5pH and 30-2,000ppb Ag<+> ion concentration and useful for cultivating plants, e.g. field crops, etc., particularly growth promoting adjuvant water consisting of Ag ion water having 350-2,000muV/cm<3> electric conductivity and 12-30ppm dissolved oxygen content and useful for cultivating plants, e.g. field crops, etc. The Ag ion water is safe for the human body without danger such as agricultural chemicals and growth of resistant germs against bacteriostatic effect of the Ag ion. The above-mentioned adjuvant water is capable of remark ably growing parts of plant roots, thickening leaves and stems and promoting the growth and maturing of fruits to increase the yield.
The present invention concerns methods of specifically inhibiting an immune response of a subject to one or more selected antigens using an immunosuppressive composition derived from a glioblastoma cell line. The method steps include obtaining a population of antigen presenting cells (APCs); loading the APC population with specific antigens (in auto-immune diseases) or using donor APCs (for transplantation); incubating the APC population with the immunosuppressive composition; and introducing the incubated cells into the subject being treated. The APCs can be monocytes, macrophages, or dendritic cells. This method causes specific inhibition of the immune response because it induces apoptosis and/or anergy in the subject's T cells specific for antigens present on the APCs, but does not affect the immune response to antigens not present on the APC surfaces. One particular embodiment of the present method is the specific inhibition of a transplant recipient's immune reaction to antigens present on the allogenic graft. A second particular embodiment of the present method is the specific inhibition of the immune response to an autoantigenic protein by a subject suffering from an autoimmune disease.
<P>PROBLEM TO BE SOLVED: To provide the delivery of antipsychotics through a predetermined inhalation route, specifically, aerosol containing the antipsychotics that are used in inhalation therapy.  <P>SOLUTION: The aerosol includes particles containing at least 5 wt.% of the antipsychotics. In a method, the antipsychotics are delivered to a mammal through the predetermined inhalation route. The method includes (a) a step for heating a composition, wherein the composition contains at least 5 wt.% of the antipsychotics, and forming vapor, and (b) a step for allowing the vapor to cool, thereby forming condensed aerosol including the particles to be inhaled by the mammal. A kit includes (a) the composition containing at least 5 wt.% of the antipsychotics and (b) a device to form the antipsychotics-containing aerosol from the composition for inhalation by the mammal, which are for delivering the antipsychotics to the mammal through the predetermined inhalation route.  <P>COPYRIGHT: (C)2011,JPO&INPIT
BACKGROUND: The primary objective of this study is to comparatively assess the safety of nasogastric (NG) feeding versus nasojejunal (NJ) feeding in patients with acute pancreatitis (AP), with a special focus on the initiation of these feeding methods within the first 48 h of hospital admission.
METHODS: Studies were identified through a systematic search in PubMed, EMbase, Cochrane Central Register of Controlled Trials, and Web of Science. Four studies involving 217 patients were included. This systematic review assesses the safety and efficacy of nasogastric versus nasojejunal feeding initiated within 48 h post-admission in moderate/severe acute pancreatitis, with a specific focus on the timing of initiation and patient age as influential factors.
RESULTS: The results showed that the mortality rates were similar between NG and NJ feeding groups (RR 0.86, 95% CI 0.42 to 1.77, P = 0.68). Significant differences were observed in the incidence of diarrhea (RR 2.75, 95% CI 1.21 to 6.25, P = 0.02) and pain (RR 2.91, 95% CI 1.50 to 5.64, P = 0.002) in the NG group. The NG group also showed a higher probability of infection (6.67% vs. 3.33%, P = 0.027) and a higher frequency of multiple organ failures. Subgroup analysis for early intervention (within 48 h) showed a higher risk of diarrhea in the NG group (RR 2.80, P = 0.02). No significant differences were found in the need for surgical intervention, parenteral nutrition, or success rates of feeding procedures.
CONCLUSION: This meta-analysis highlights the importance of considering the method and timing of nutritional support in acute pancreatitis. While NG feeding within 48 h of admission increases the risk of certain complications such as diarrhea and infection, it does not significantly impact mortality or the need for surgical intervention.
FIELD: medicine. SUBSTANCE: protein with molecular mass 37-30 kD isolated from external cell wall of glanderous microbe which, probably, operates as pore-forming agent is administrated to glanders-sensitive mammals at the dose 10-30000 mg/kg mass by subcutaneous route. Immunization is repeated after 12-27 days. Method provides the survival 83% golden hamsters infected 50-100 lethal doses of agar culture of high-virulent strain by subcutaneous route. EFFECT: improved method of prophylaxis. 2 tbl
PURPOSE:To provide a novel peptide having specific amino acid sequences isolated from the skin of Nigromaculata, etc., having a strong histamine- releasing activity and an antibacterial activity against gram-positive bacteria, gram-negative bacteria, etc., and useful as an antibacterial agent. CONSTITUTION:The skin of Nigromaculata, Rana.brevipoda, etc., is extracted with a 1M acetic acid solution under boiling, and they filtered. The filtrate is dialyzed through a dialytic membrane cutting molecules having mol.wts. of >=1000 with a 1M acetic acid solution for 12hr to remove salts and low mol.wt. amines. The solution inside the dialytic membrane is passed through a gel filtration column and subsequently eluted with a pyridine-acetic acid solution. The eluted fraction is concentrated and dried under vacuum, dissolved in water, and subsequently subjected to a reverse phase high performance liquid chromatography, followed by separating an elusion fraction having an antibacterial activity to provide the objective peptide having amino acid sequences of formulas I and II, the brevinin-1 of formula I having an antibacterial activity against gram-positive bacteria, and the brevinin-2 of formula II having an antibacterial activity against gram-positive bacteria and gram-negative bacteria.
Autosomal dominant tubulointerstitial kidney disease (ADTKD) comprises a heterogeneous group of rare hereditary kidney diseases characterized by family history of progressive chronic kidney disease (CKD) with bland urine sediment, absence of significant proteinuria and normal or small-sized kidneys. Current diagnostic criteria require identification of a pathogenic variant in one of five genes - UMOD, MUC1, REN, HNF1β, SEC61A1. The most prevalent form of ADTKD is uromodulin-associated kidney disease (ADTKD-UMOD). Genetic study of a Portuguese family diagnosed with familial juvenile hyperuricemic nephropathy (FJHN), one of the nosological entities in the spectrum of ADTKD, revealed a previously unreported large deletion in UMOD encompassing the entire terminal exon, which strictly cosegregated with CKD and hyperuricemia/gout, establishing the primary diagnosis of ADTKD-UMOD; as well as an ultra-rare nonsense SLC8A1 variant cosegregating with the UMOD deletion in patients that consistently exhibited an earlier onset of clinical manifestations. Since the terminal exon of UMOD does not encode for any of the critical structural domains or amino acid residues of mature uromodulin, the molecular mechanisms underlying the pathogenicity of its deletion are unclear and require further research. The association of the SLC8A1 locus with FJHN was first indicated by the results of a genome-wide linkage analysis in several multiplex families, but those data have not been subsequently confirmed. Our findings in this family revive that hypothesis.
Respiratory depression and death have occurred in children who received codeine in the post-operative period following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine (i.e., multiple copies of the gene for cytochrome P450 isoenzyme 2D6 or high morphine concentrations). Deaths have also occurred in nursing infants who were exposed to high levels of morphine in breast milk because their mothers were ultra-rapid metabolizers of codeine. [see Use in Specific Populations (8.3)]

Some individuals may be ultra-rapid metabolizers because of a specific CYP2D6 genotype (gene duplications denoted as *1/*1xN or *1/*2xN). The prevalence of this CYP2D6 phenotype varies widely and has been estimated at 0.5 to 1% in Chinese and Japanese, 0.5 to 1% in Hispanics, 1 to 10% in Caucasians, 3% in African Americans, and 16 to 28% in North Africans, Ethiopians, and Arabs. Data are not available for other ethnic groups. These individuals convert codeine into its active metabolite, morphine, more rapidly and completely than other people. This rapid conversion results in higher than expected serum morphine levels. Even at labeled dosage regimens, individuals who are ultra-rapid metabolizers may have life-threatening or fatal respiratory depression or experience signs of overdose (such as extreme sleepiness, confusion, or shallow breathing). [see Overdosage (10)]

Children with obstructive sleep apnea who are treated with codeine for post-tonsillectomy and/or adenoidectomy pain may be particularly sensitive to the respiratory depressant effects of codeine that has been rapidly metabolized to morphine. CODEINE PHOSPHATE AND CHLORPHENIRAMINE MALEATE is contraindicated for post-operative pain management in all pediatric patients undergoing tonsillectomy and/or adenoidectomy [see Contraindications (4)].

When prescribing codeine-containing drugs, healthcare professionals should choose the lowest effective dose for the shortest period of time and inform patients and caregivers about these risks and the signs of morphine overdose. [see Use in Specific Populations (8),Overdosage (10)]
Pulmonary arterial hypertension (PAH) causes pulmonary vascular remodeling, increasing pulmonary vascular resistance (PVR) and leading to right heart failure and death. Matrix stiffening early in the disease promotes remodeling in pulmonary artery smooth muscle cells (PASMCs), contributing to PAH pathogenesis. Our research identified YAP and TAZ as key drivers of the mechanobiological feedback loop in PASMCs, suggesting targeting them could mitigate remodeling. However, YAP/TAZ are ubiquitously expressed and carry out diverse functions, necessitating a cell-specific approach. Our previous work demonstrated that targeting non-canonical IKB kinase TBK1 reduced YAP/TAZ activation in human lung fibroblasts. Here, we investigate non-canonical IKB kinases TBK1 and IKKε in pulmonary hypertension (PH) and their potential to modulate PASMC pathogenic remodeling by regulating YAP/TAZ. We show that TBK1 and IKKε are activated in PASMCs in a rat PH model. Inflammatory cytokines, elevated in PAH, activate these kinases in human PASMCs. Inhibiting TBK1/IKKε expression/activity significantly reduces PAH-associated PASMC remodeling, with longer-lasting effects on YAP/TAZ than treprostinil, an approved PAH therapy. These results show that non-canonical IKB kinases regulate YAP/TAZ in PASMCs and may offer a novel approach for reducing vascular remodeling in PAH.
The invention discloses a production formula of skin cream and a preparation method of the skin cream. The skin cream consists of white gourd extract, Sanhuang extract, rose oil, stearic acid, glycerin monostearate, setanol, sapium seed oil, vitamin E, vitamin C and potassium hydroxide. The raw materials of white gourd extract consist of white gourd, Chinese rose, Chinese angelica and ginseng. The raw materials of Sanhuang extract consist of scutellaria baicalensis, cortex phellodendri, rhubarb, polygonum cuspidatum and radix paeoniae alba. The production device of the skin cream is a vacuum homogenizing and emulsifying device, and the skin cream is produced by the emulsification reaction of the materials. The skin cream comprises various vitamins, amino acids and active enzymes which can be absorbed by human skin and has the functions of facilitating the metabolism of the cells and tissues of human body, promoting the blood circulation, nourishing the skin and keeping the elasticity and moist of human skin. The skin cream has rational formula and advanced process; and the produced cream is fine and smooth, and has pure aroma and good skin care effect.
OBJECTIVE: SETD1A encodes a histone methyltransferase involved in various cell cycle regulatory processes. Loss-of-function SETD1A variants have been associated with numerous neurodevelopmental phenotypes, including intellectual disability and schizophrenia. While the association between rare coding variants in SETD1A and schizophrenia has achieved genome-wide significance by rare variant burden testing, only a few studies have described the psychiatric phenomenology of such individuals in detail. This systematic review and case report aims to characterize the neurodevelopmental and psychiatric phenotypes of SETD1A variant-associated schizophrenia.
METHODS: A PubMed search was completed in July 2022 and updated in May 2023. Only studies that reported individuals with a SETD1A variant as well as a primary psychotic disorder were ultimately included. Additionally, another two previously unpublished cases of SETD1A variant-associated psychosis from our own sequencing cohort are described.
RESULTS: The search yielded 32 articles. While 15 articles met inclusion criteria, only five provided case descriptions. In total, phenotypic information was available for 11 individuals, in addition to our own two unpublished cases. Our findings suggest that although individuals with SETD1A variant-associated schizophrenia may share a number of common features, phenotypic variability nonetheless exists. Moreover, although such individuals may exhibit numerous other neurodevelopmental features suggestive of the syndrome, their psychiatric presentations appear to be similar to those of general schizophrenia populations.
CONCLUSIONS: Loss-of-function SETD1A variants may underlie the development of psychosis in a small percentage of individuals with schizophrenia. Identifying such individuals may become increasingly important, given the potential for advances in precision medicine treatment approaches.
PURPOSE:A cardiotonic agent containing a specific quinone compound. CONSTITUTION:A cardiotonic agent containing a compound expressed by the formula (X is H2 or O) as an active constituent. The dose thereof is 0.1-1mg/kg/ day for parenteral administration and 1-10mg/kg/day for oral administration. The dosage form is tablet, capsule, powder, granule, solution, etc. for the oral use, and sterilized liquid, e.g. suspension, for the parenteral use. In the case of oral use, the agent contains 5-100wt%, preferably 25-100wt% active constituent. In the case of an injection, the agent contains 0.5-20wt%, preferably 1- 10wt% active constituent. The compound expressed by the formula which is the active constituent is obtained by cushing a certain kind of sponge, e.g. Xestospongia sapra, extracting the crushed sponge, and purifying the resultant extract. EFFECT:The agent is capable of increasing the contracting action of excised myocardium depending on the dose, and Na<+> or K<+>-ATPase is inhibited depending on the dose.
MI will start immediately when the sample is going to start the exercise program. The intervention group will undergo 24 sessions of imagery, starting from the 1st exercise program session. Participants of the intervention group will undergo a 45-minute imagery session sitting in a quiet place after the end of every exercise program session. The content of every imagery session is alike with the content of the exercise program session. That means that every session includes imagery of the same exercises of the exercise program performed earlier by the subject in the Day Center. Sessions are identical for all subjects of the intervention group. The total duration of the physiotherapy exercise program will be 24 sessions, 2 times/week, duration of 45 minutes each session, 3 months (12 weeks).
Professional CGM measures interstitial glucose every 5 minutes via a glucose-oxidase-impregnated membrane during a 3 day period. The patient wearing professional CGM is blinded to the repeated measurements and the data is stored for retrospective analysis.
Outcome prediction is essential for the administration and treatment of critically ill patients. For those patients, clinical measurements are continuously monitored and the time-varying data contains rich information for assessing the patients' status. However, it is unclear how to capture the dynamic information effectively. In this work, multiple feature extraction methods, i.e. statistical feature classification methods and temporal modeling methods, such as recurrent neural network (RNN), were analyzed on a critical illness dataset with 18415 cases. The experimental results show when the dimension increases from 10 to 50, the RNN algorithm is gradually superior to the statistical feature classification methods with simple logic. The RNN model achieves the largest AUC value of 0.8463. Therefore, the temporal modeling methods are promising to capture temporal features which are predictive of the patients' outcome and can be extended in more clinical applications.