anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUNDS: Currently, family with sequence similarity 65 member A (FAM65A) is reported as a pivotal regulator in various cancers. However, the effect of FAM65A in lung squamous cell carcinoma (LSCC) is still unclear, the prime objective of this research is to explore the role of FAM65A in LSCC.
METHODS: Gene expression data and correlated clinical information were downloaded from the public database and the expression of FAM65A was detected. The expression of FAM65A was also detected in our collected clinical samples and LSCC cell lines. Survival package of R language was used to determine the survival significance of FAM65A. Proteins expression level was determined via western blot assay. Cell function experiments and in vivo experiments were performed to explore the effect of FAM65A on LSCC cell biological behaviors.
RESULTS: FAM65A expression was significantly increased in LSCC clinical samples and cell lines. High FAM65A expression predicted poor prognosis in LSCC patients. After silencing FAM65A, the ability of LSCC cell proliferation, invasion and migration was decreased, and LSCC cell cycle was blocked. Moreover, in vivo experiments revealed that silencing FAM65A could inhibit LSCC cell proliferation.
CONCLUSIONS: High FAM65A expression could enhance proliferative, invasive and migratory abilities of LSCC. FAM65A might be a novel biomarker of LSCC.
Through an experimental study, Tylenol is synthesized with an eco-friendly method by using a new method irradiating 4-aminophenol and glacial acid mixture with microwaves under a solventless condition. By the method, the reaction time of the conventional Tylenol-manufacturing method is remarkably reduced to 4 minutes from 2 hours. The reaction yield is improved by 50 % or more than that of the conventional method. From the study, a new fact that inserting a test tube into a beaker filled with alumina and conducting reaction can prevent overheating is obtained. The study provides a new fact that, in a heating method, a sequential irradiation method is more effective than a continuous microwave irradiation. In a dehydration condensation, a heating with microwaves is very effective. If Tylenol is generated with the new method, a domestic new medicine development which faces a difficulty due to Korea-USA FTA will find a solution, and a Le Chatelier law in a high school chemistry class can be easily proved, thereby being used for a good practical exercise in the chemistry class.
Mother-daughter pairs will partake in an educational session at the baseline visit, which will cover topics on reading product labels, cleaning habit, and cooking methods for reducing environmental exposures. Educational materials will be adapted from the Environmental Protection Agency (EPA) and other accredited sources. Participants will also be introduced to free resources for consumer product safety information, such as the Detox Me phone application. Participants in the intervention arm will receive a 6-month supply of soap, lotion, deodorant, lip balm, a mop, cleaning cloths, and an air filter to take home with them. Mother-daughter pairs in both study arms will return for a second clinic visit 6 months after the pre-intervention visit for blood and urine sample collection, Optical Spectroscopy (OS) measurement, and questionnaire completion.
Participants randomized to this arm received one intravenous (IV) infusion of either MSTT1041A-matched placebo or UTTR1147A-matched placebo on Day 1. A second IV infusion of either MSTT1041A-matched placebo or UTTR1147A-matched placebo (same placebo as the first infusion) was given on Day 15 if the participant remained hospitalized with a requirement for supplemental oxygen. Study treatment was given in combination with the standard of care for COVID-19 pneumonia.
The treatment group will receive all the usual discharge treatment, instructions and information for acute coronary syndrome patients as well as the Txt2Prevent text-messaging program. The program will include a variety of topics such as standard follow-up care reminders as well as general self-management and healthy living texts. There will be two streams, one for current/recent smokers and one for non-smokers. Texts will be sent out every 1-3 days for 60 days. All participants in the same stream will receive the same texts in the same order.
Dietary choline (mainly refer to phosphatidylcholine, PC) produce trimethylamine (TMA) through the action of gut flora in vivo. TMA then readily absorbed into systemic circulation and oxidized by hepatic flavin monoxygenases (FMO3) to trimethylamine-N-oxide (TMAO). The elevated levels of circulating TMAO is identified as a risk factor for the prevalence and development of metabolic diseases such as cardiovascular diseases and nonalcoholic fatty liver diseases. Targeting gut flora for reducing TMAO may be a promising approach for preventing chronic metabolic diseases. Recent studies found that some strains representing two different phyla (Firmicutes and Proteobacteria) are capable of producing TMA from choline in vitro. On the other hand, TMA intervention can change the structure of intestinal flora, reducing the abundance of bifidobacterium and lactobacillus. Probiotics can improve the ecological balance of the gut flora, which might be beneficial to human health and disease prevention. However, whether probiotics could inhibit the TMA-producing bacterias and reduce the TMA and TMAO levels through balancing the gut flora was unclear.

In order to explore whether probiotics can reduce the TMA and TMAO levels, we are proposed to recruit 50 volunteers aged from 18-30 years old to participate in the randomized double-blind trial. The volunteers are randomized allocated into different intervention groups. The probiotics intervention group is provided once daily orally-taken powder in a sachet, which contains 4 strains of probiotics. The non-probiotic control is provided with a powder without probiotics , but has same look, color, taste, flavor and weight as the probiotics intervention group. A PC challenge test will be hold before and after the 4 weeks intervention. The blood and fecal sample will be collected before and after the trial and analyzed by appropriate method. The dietary assessment is assessed by a 3-day dietary record.The statistic analysis is by SPSS 23.0.
Pulmonary rehabilitation has been proven to benefit COPD patients in terms of quality of life and functional capabilities. The effects of pulmonary rehabilitation (exercise) on immune function are unclear despite clear benefits of exercise on immune function in healthy individuals being identified. Moderate-intensity and frequency of exercise has been shown to decrease the risk of upper respiratory tract infections in healthy individuals in comparison to sedentary individuals. Respiratory infections, also known as exacerbations, in COPD are the main cause of hospitalisation and mortality. Therefore, if exercise can modulate immune function in COPD, it can be encouraged further in COPD to reduce hospitalisation risk. However, it is important to compare the effects of exercise amongst different phenotypes as frequent exacerbators are known to have elevated inflammatory markers, and may consequently respond to exercise differently to infrequent exacerbators, paving a rationale for a different approach to this subset of patients.
PURPOSE:To coat a solid drug effectively, without inhibiting the disintegration and dissolution of the drug, by using a coating liquid composed of a combination of pullulan and a water-dispersed coating agent comprising a methacrylic acid- acrylic acid copolymer. CONSTITUTION:A water-dispersed coating agent comprising a methacrylic acid- acrylic acid copolymer is compounded with 10-30% pullulan of formula, and a solid drug (e.g. tablet, pill, granule, powder, etc.) is coated with the above coating agent. The combination of the above water-dispersed coating agent with the pullulan which is a neutal glucan of a natural polysaccharide is a method to satisfy the requirements such as excellent film-forming property, improvement in the coating operation, resistance to the degradation with time, and interness to demulsification. The pullulan may be the one commercially available as a food additive.
Patients undergo proton beam radiation therapy 5 days a week over 3 weeks. Patients undergo PET scan, CT scan, MRI, and blood sample collection throughout the study.
Participants receive low-intensity transcranial magnetic stimulation interventions with audio-visual stimulation for 14 days. On days 6, 7, 13, and 14 of the study, participants will not receive any interventions. Participants will be screened and tested on days 1 and 14 of treatment and two weeks after the end of the intervention.
DynamiCare Plus Methadone Treatment-as-Usual (DCM+TAU) participants will receive the same services as TAU participants, plus access to the DynamiCare Health smartphone app for 48 weeks. After randomization, the research assistant (RA) will download the DynamiCare Health app onto their smart phone (or provide them with a smartphone with the app already installed). Participants will get oral fluid testing kits and a Next Step debit card. Participants will be trained in use of the app and oral fluid test kits and will practice until they can produce two valid tests in a row without aid of the research staff. Participants will earn $40 for successful completion of the orientation and training. DCM+TAU participants will then use the app to complete remote random drug screenings, prove attendance to appointments and medication pickups, interact with modules designed to improve substance use reductions, and other treatment-related activities.
Transient global amnesia (TGA) is a typical clinical syndrome characterized by acute, predominantly anterograde amnesia. New epidemiological data assume a significantly higher annual incidence than previously assumed, namely around 15 cases per 100,000 people. Those affected, usually over the age of 50, cannot remember new memory content for longer than 30-180 seconds and therefore ask repetitive questions about current events. All other cognitive functions are unimpaired, and everything previously learnt, e.g. driving or cooking, can be carried out. The episodes are self-limiting and by definition subside within 24 hours. At least 10% of those affected will experience 1-5 recurrences in the future. The punctate lesions in the hippocampus, which are found on MRI in at least 50% of patients after 24-72 hours, are distributed 2/3 unilaterally and 1/3 bilaterally. Using 7 Tesla MRI the frequency of detected lesions increases to 90% compared to 50% with 1.5 or 3 Tesla. Beyond the punctiform hippocampal lesions, other memory-related network disorders, including the default network, are also suggested to be involved in the pathomechanism of TGA. TGA etiology and pathophysiology are not known in detail. Vascular, migraine-like, epilepsy-like, and psychogenic mechanisms are discussed. Triggers of the episodes are often physical exertion with a Valsalva character. Management is aimed at identifying the syndrome based on the typical clinical presentation and ruling out possible differential diagnoses with similar symptoms. During the TGA, the usually anxious relatives should be reassured of the benign and inconsequential nature of the episode.
This study will be a double-blind randomized controlled trial (evaluator and patient), parallel in three groups (experimental group, Sham and control). Participants will initially be evaluated by a trained investigator who will be blinded and assigned randomly (random numbers generated on the computer) block for the experimental, sham, and control groups by means of an opaque envelope draw. In group division, participants with pain may not be contemplated to participate in the myofascial release protocol intervention group. However, the research will count on a group that will be contemplated with the technique of continuous superficial sliding (massage), which in turn, the literature points out benefits and well-being in its application. Finally, a group of individuals without pain will be evaluated and reevaluated and evaluated as a means of preventing pain and reducing TM peripheral muscle oxygenation. When making the invitation to participate in the survey, individuals will not be required to participate if they do not agree, and therefore will not be penalized. Participants who agree to participate in the survey will sign a Free and Informed Consent Form (Annex I) and will be informed of the possibility of withdrawing from the survey at any stage, without penalty. The collection of the evaluation and intervention will be carried out in a salon Clinic School of Physiotherapy in the Center of Health and Sports Sciences (CEFID) of the State University of Santa Catarina (UDESC) in the city of Florianópolis - SC. All personal identification data of the participants will be preserved according to resolution of the national health council, taking into account the possibility of scientific dissemination of the results obtained. The risks of these procedures will be medium, since the participant may present muscle pain after the intervention protocol. To minimize these risks will be available, if necessary, attendance at the Clinic School of Physiotherapy. Volunteers of both sexes, aged from 18 years neck pain more specifically, in TM during daily or work activities. The sample will be selected in a non-probabilistic way for convenience, and the individuals will be divided into three groups: experimental, Sham and control. The control group will be formed by healthy individuals and will be paired with the experimental group according to age and gender taking into account that they are two relevant variables when addressing the fascia.
Portable medication delivery system for treatment of bad breath, gingivitis, ANUG, plaque, etc., comprising small, shirt pocket-sized re-closable pouches having 2 to 4 sterile, single-use, disposable, treated cotton rolls carrying a selected periodontal anti-microbial, such as mouthwash, or a fluoride, enzyme or antibiotic composition. The anti-microbial is preferably a neutral, alcohol-free solution, but may be a dry or gel composition. The treated rolls are placed in the upper and/or local buccal vestibules where they release, over time, the anti-microbial solution. The treatment directly targets the critical areas, tiny ~sulcus~ grooves and spaces between the teeth, both significant reservoirs for bacteria. The rolls are left in place for extended periods, on the order of 5-30 minutes or more, without discomfort and without interfering with normal activities of speaking or travel. Tests show the inventive medicated rolls are truly effective in treatment of bad breath.
PURPOSE: To obtain an oral administration medicine having protecting action on gastric mucosa, useful for preventing a sore wall of stomach caused by an analgesic antipyretic by blending an active ingredient of an oral administration medicine with a soluble protein component. CONSTITUTION: This oral administration medicine is obtained by blending (A) an active ingredient of an oral administration medicine with (B) a soluble protein component. A water-soluble protein such as casein, a milk component and globulin (glycinin) as a soybean protein component are cited as the component B. The amount of the component B mixed is preferably twice or more than and four times or less than the amount of the component A. The oral administration medicine is obtained by mixing an analgesic antipyretic component as the component A with a milk component as the component B to give the objective oral administration medicine having excellent action. The components A and B both in a powdery state are preferable in terms of handleability.
Embodiments described herein relate to an apparatus having a processor and a memory storing instructions which when executed configure the processor to generate incident prediction alerts for transmission to a health care organization system by applying rules to data sets. Each rule may define a set of data elements linked to an incident, and the processor may be further configured to detect one or more sets of data elements in the data sets. The processor may be configured to normalize the data feeds, generate rules on historical data, generate prediction alerts by applying rules to near-real time data feeds, train to update rules, validate and error check rules, remove statistical noise, generate visualizations for the data feeds, and receive input and feedback data. Embodiments further relate to a system for health care incident alerts made up of the apparatus connected via a network to a plurality of clients accessed by user stations of the health care organization, and a data repository. The apparatus may be configured to connect via the network to devices and machines within the health care organization to receive data feeds therefrom. Embodiments further relate to non-transitory computer readable medium with instructions encoded thereon to configure the apparatus.
Primary care offers an ideal setting in which to treat OUD; however, few clinicians are waivered to prescribe buprenorphine and of those who are waivered, less than one-third do prescribe. One potential barrier to increasing access to MOUDs are primary care clinician (PCC) attitudes towards people with OUD.

This study used a randomized controlled trial design to examine a novel intervention to change attitudes towards people with OUD among PCCs. PCCs in clinics randomized to the intervention in COMPUTE 2.0 (PCCs in 15 of the 30 clinics randomized in the parent study) were randomized 1:1 to the intervention or comparison training, stratified by clinic and waiver status. Training was conducted via MyLearning, an online learning software. All PCCs were asked to complete a brief training (25-35 minutes for both trainings) on the shared decision-making tool (SDM) called the Opioid Wizard, which alerts PCCs to screen, diagnose, and treat people with OUD. PCCs in the intervention arm heard patient narratives designed to shift attitudes about patients with OUD. PCCs in the comparison training had training on using the SDM tool. The PCCs were asked to complete a survey of attitudes and intentions to get waivered to prescribe buprenorphine immediately following the online training. Use of the CDS was monitored in both groups for 6 months.
BACKGROUND: Urge urinary incontinence (UUI) commonly occurs in elderly female patients. The application research of the Information-Motivation-Behavioural Skills (IMB) model has been applied in various therapeutic contexts, but research on its application in UUI management is limited.
METHODS: Elderly female patients diagnosed with UUI were selected as the research subjects, and they were divided into two groups. All patients were given pelvic floor muscle training. The control group received routine health education management, whereas the observation group received health education management on the basis of the IMB model in addition to routine education. Before and after treatment, the severity of urinary incontinence was evaluated using a 1 h urine pad test. The anxiety and depression statuses were evaluated using Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS). Incontinence Quality-of-Life (I-QOL) was used to evaluate the quality of life of patients.
RESULTS: After treatment, the leakage volume, SAS and SDS scores of both groups significantly decreased (p < 0.001), with the observation group having significantly lower leakage volume, SAS, and SDS scores than the control group (p < 0.001). The I-QOL scores of both groups increased (p < 0.001), and the observation group had significantly higher scores than the control group (p < 0.001).
CONCLUSIONS: Health education interventions based on the IMB model can improve urinary leakage in elderly women with UUI, improve their negative emotions and enable them to have an enhanced quality of life.
The micro implant (10) has an energy converter (30) for converting applied energy to heat, where the energy converter is situated in a way such that the heat generated from energy conversion is active at an outer surface of the implant. The energy converter is arranged with an electric heating element. The energy converter is connected to an antenna to receive electrical power applied via an alternating electromagnetic field. The antenna is connected to the electric heating element in a way such that the electrical power is converted to heat in the electric heating element. The implant is made of magnetizable, demagnetizable material and biodegradable material. The antenna is made of absorbable materials.
This study is designed as a prospective single-center registry study and has been approved by the Ethics Committee of Sisli Hamidiye Etfal Training and Research Hospital on May 30, 2023. The inclusion criteria for study involve patients scheduled for colonoscopy in surgical endoscopy unit who have not undergone colorectal surgery. Following informed consent obtained from patients before colonoscopy, data forms prepared by investigators will be completed, evaluating patients' age, height, weight, body mass index, colonoscopy indication, antidepressant use, and history of abdominal surgeries. Additionally, the Wexner constipation score will be calculated for each patient.

The time taken to reach the cecum and, if intubated, the ileum, from the initial insertion of the endoscope in colonoscopy, as well as the total procedure time, will be recorded using a chronometer. Patients with inadequate bowel preparation preventing cecal intubation will be excluded from the study. The collected data will be analysed to assess factors prolonging cecal intubation time and, if possible, to identify predictors for difficult colonoscopy before procedure.
Sepsis-induced acute kidney injury (S-AKI) is a severe and frequent complication that occurs during sepsis. This study aimed to understand the role of FOXQ1 in S-AKI and its potential upstream and downstream regulatory mechanisms. A cecal ligation and puncture induced S-AKI mouse model in vivo and an LPS-induced HK-2 cell model in vitro were used. FOXQ1 was significantly upregulated in CLP mice and downregulated in the LPS-induced HK-2 cells. Upregulation of FOXQ1 improved kidney injury and dysfunction in CLP mice. Overexpression of FOXQ1 remarkably suppressed the apoptosis and inflammatory response via down-regulating oxidative stress indicators and pro-inflammatory factors (IL-1β, IL-6, and TNF-α), both in vivo and in vitro. From online analysis, the CREB5/NF-κB axis was identified as the downstream target of FOXQ1. FOXQ1 transcriptionally activated CREB5, upregulating its expression. Overexpression of FOXQ1 suppressed the phosphorylation level and nucleus transport of p65. Rescue experiments showed that CREB5 mediates the protective role of FOXQ1 on S-AKI. Furthermore, FOXQ1 was identified as a substrate of USP10, a deubiquitinating enzyme. Ectopic expression of USP10 reduced the ubiquitination of FOXQ1, promoting its protein stability. USP10 upregulation alleviated LPS-induced cell apoptosis and inflammatory response, while suppression of FOXQ1 augmented these trends. Collectively, our results suggest that FOXQ1, deubiquitinated by USP10, plays a protective role in S-AKI induced inflammation and apoptosis by targeting CREB5/NF-κB axis.
Participants will receive placebo QD for 12 weeks. Participants will be re-randomized at week 12 to receive atogepant dose A, dose B or dose C QD for 12 weeks.