anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
During the Induction phase, participants receive pembrolizumab 200 mg q3w for 4 cycles, carboplatin area under the curve (AUC) 6 (mg/mL/min) q3w for 4 cycles, and paclitaxel 200 mg/m2 q3w for 4 cycles or nab-paclitaxel 100 mg/m2 weekly for 4 cycles. During the Maintenance phase, participants receive sac-TMT 4 mg/kg infusion every 2 weeks (q2w) after receipt of an antihistamine, H2 receptor antagonist, acetaminophen (or equivalent), and dexamethasone (or equivalent) until discontinuation criteria is met for sac-TMT; and pembrolizumab 400 mg every 6 weeks (q6w) for 96 weeks.
High levels of proinflammatory cytokines induce neurotoxicity and catalyze inflammation-driven neurodegeneration, but the specific release mechanisms from microglia remain elusive. Here we show that secretory autophagy (SA), a non-lytic modality of autophagy for secretion of vesicular cargo, regulates neuroinflammation-mediated neurodegeneration via SKA2 and FKBP5 signaling. SKA2 inhibits SA-dependent IL-1β release by counteracting FKBP5 function. Hippocampal Ska2 knockdown in male mice hyperactivates SA resulting in neuroinflammation, subsequent neurodegeneration and complete hippocampal atrophy within six weeks. The hyperactivation of SA increases IL-1β release, contributing to an inflammatory feed-forward vicious cycle including NLRP3-inflammasome activation and Gasdermin D-mediated neurotoxicity, which ultimately drives neurodegeneration. Results from protein expression and co-immunoprecipitation analyses of male and female postmortem human brains demonstrate that SA is hyperactivated in Alzheimer's disease. Overall, our findings suggest that SKA2-regulated, hyperactive SA facilitates neuroinflammation and is linked to Alzheimer's disease, providing mechanistic insight into the biology of neuroinflammation.
The invention relates to traditional Chinese medicine radix curcumae-tangerine peel powder for treating anorexia. The traditional Chinese medicine radix curcumae-tangerine peel powder is mainly used for solving the problem that the current drugs for treating pediatric epilepsy are poor in treatment effect and have side effects. The traditional Chinese medicine radix curcumae-tangerine peel powder is prepared through the steps of weighing 5 parts of tangerine peel, 5 parts of nutagrass flatsedge rhizome, 5 parts of fried fructus aurantii, 5 parts of yam, 5 parts of radix curcumae, 5 parts of parched hawthorn fruit, 3 parts of chicken gizzard membrane and 3 parts of licorice root, and co-grinding into fine powder. The usage and dosage are as follows: the powder is orally taken once in the morning and evening of a day, the dosage for children of 1-3 years old is 5g, and the dosage for children of 4-6 years old is 8g; a treatment course lasts one month. The traditional Chinese medicine radix curcumae-tangerine peel powder has the aims and advantages that the total effective rate for anorexia treatment is over 95%, and the cure rate is over 80%. The traditional Chinese medicine radix curcumae-tangerine peel powder is free from toxic and side effects.
Amputations take place in the operating rooms. At dangerous sites, circumstances may necessitate on-site amputation to save lives. Currently, there are no evidence-based guidelines for the execution of the amputation or the instruments to be chosen. Furthermore, there are no widely accepted criteria for the standardized characterization of amputation devices. The present study examined the effectiveness of commercially available cutting tools and instruments used by rescue services as possible on-site amputation tools. Five different tools (Holmatro type hydraulic cutter, with two cutting attachments, reciprocating saw, hacksaw, Gigli saw) were used to carry out amputations on designated locations on cadavers (brachial, antebrachial, femoral, and crural regions). During the experiment, the time required for amputation and the number of necessary cutting attempts to detach limbs were recorded. The proximal cut surfaces were analyzed with the help of post-amputation CT scan-based 3D models. An Amputation Index (AI) was determined for each device in each examined region based on the cut surface quality. An Amputation Score (AS) was calculated using the time required for cutting, the number of cutting attempts, and the AI. With the help of AS, the usability of the used devices was determined. According to our scoring system, the reciprocating saw proved the most effective tool. Based on our results, we recommend the consideration and further investigation of the reciprocating saw as a possible on-site amputation device, as well as the introduction of the Amputation Score as an objective and quantitative indicator in the future characterization of on-site amputation devices.
The invention discloses a Chinese traditional medicine compound for treating parkinsonism syndrome, belonging to the Chinese traditional medicine field. The Chinese traditional medicine compound for treating parkinsonism syndrome is prepared by ligustrum lucidum of10-20g, red sage root of 5-15g, rhizoma gastrodiae of 5-15g, Cortex Moutan of 5-15g, angelica of 5-15g, earthworm of 10-20g, radix codonopsitis of 10-20g, prepared rhizome of rehmannia of 10-20g, arisaema cum bile of 8-15g, radix curcumae of 10-20g and polygala of 5-15g. Impurities of each crude drug should be removed first, and then the crude drugs are put into an earthen pot. Then 500ml of water is added for decoction for half an hour. The invention is taken with one dosage a day and with one dosage taken twice. The invention is provided with such function as eliminating phlegm and wetness, promoting qi and activating blood circulation. In addition, the invention is extensive in material sources, cheap and easy to get and free of side effect.
The chemotherapeutic agent Doxorubicin (DOX) is known to cause chemotherapy-induced cognitive impairment (CICI). Maraviroc, a potent C-C chemokine receptor 5 (CCR5) antagonist, shows neuroprotective properties, while its role in CICI remains unclear. This study determined the therapeutic potential of maraviroc on CICI. Adult C57BL/6J mice with implanted breast cancer cells received four weekly intraperitoneal injections of saline (Control group), 5 mg/kg DOX (DOX group), 10 mg/kg maraviroc (MVC group), or 5 mg/kg DOX with 10 mg/kg maraviroc (DOX + MVC group). The Morris Water Maze (MWM) was used for neurobehavioural test. Western blot analysis and immunofluorescence were used to evaluate the expressions of inflammatory markers, apoptosis-related proteins, and synaptic-related proteins. The volume and weight of tumor were also evaluated after treatments. DOX treatment significantly increased chemokines (CCL3, CCL4) and inflammatory cytokines (IL-1β, TNF-α) in tumor-bearing mice hippocampus. While maraviroc administration reduced hippocampal proinflammatory factors compared to the DOX group. Furthermore, it also lowered apoptosis markers, restored synaptic proteins levels, and inhibited the NF-κB/NLRP3 pathway. Accordingly, maraviroc treatment significantly improved DOX-induced neurobehavioural impairments as evidenced by an increased number of platform crossings and percentage of target quadrant time in the MWM test. Additionally, when combined with DOX, maraviroc had additional inhibitory effects on tumor growth. These findings suggest that maraviroc can mitigate DOX-induced CICI by suppressing elevated proinflammatory chemokines and cytokines through the NF-κB/NLRP3 pathway, potentially offering an anti-tumor benefit. This research presents a promising therapeutic approach for DOX-induced CICI, enhancing the safety and efficacy of cancer treatments.
A randomized controlled trial was performed with thirty children with cerebral palsy recruited from Thammasat University Hospital and Rajanukul institute. Informed consent was obtained from the participants' parents before participation in this study. The participants were randomly assigned according to the randomization list to receive either the mirror neurons stimulation based VCD program and practice at home or conventional physical therapy for six months. The participants in the experiment group received the mirror neurons stimulation based VCD program and practice at home three times a day for six months. Concerning the control group, the participants received conventional physical therapy regularly at the hospital once a week for first two months and twice a month for last four months. Both experimental and control groups were measured their motor functions with gross motor function measure (GMFM-66).
Subjects from this group will perform 2 weeks of DGB with the DGB2 system immediately after 1 week of baseline monitoring. All subjects will answer questionnaires pertaining to their sleep quality.
PURPOSE: A cosmetic composition for anti-aging containing fermented medicinal herb extract is provided to ensure high anti-oxidation, cell activity, and collagen synthesis. CONSTITUTION: A cosmetic composition for anti-aging contains fermented medicinal herb extract as an active ingredient obtained by adding and culturing yeast or lactobacillus. The medicinal herb is Zingiberis Rhizoma crudus, Angelicae dahuricae Radix and Poncirus trifoliate. The yeast contains one or more selected from Saccharomyces sp., Schizosaccharomyces sp., Torulopsis sp., Rhodotorula sp., and Candida sp. The lactobacillus is selected one or more from Lactobacillus sp., Streptococcus sp., Leuconostoc sp., and Bifidobacteria sp. The cosmetic composition is used in the form of skin external ointment, nutrition cream, massage cream, essence, pack, emulsion, or oil gel.
BACKGROUND: Structural muscle injuries are characterized by acute and localized onset of pain. Abdominal muscle injuries are an insidious pathology in overhead athletes. However, only a few cases are reported in literature related to volleyball players, where clinical presentation may not have reflected the severity of the lesion.
CASE PRESENTATION: An elite volleyball player, a 21-year-old Caucasian female, reported the onset of mild abdominal muscular pain, confirmed on clinical evaluation findings and self-reported symptoms. Abdominal muscle ultrasound was performed following 2 weeks of continuing symptoms. This evidenced a more serious structural muscle injury of the rectus abdominis (type 3b). Having this correct diagnosis allowed a personalized rehabilitation program to be instituted to enable a safe return to play.
CONCLUSION: In presence of persistent abdominal muscle pain, even if mild, the possibility of a structural muscle injury must be considered. Clinical evaluation must be complemented by an instrumental evaluation including an ultrasound by an experienced operator for correct diagnosis and the setting of functional recovery related to biological healing.
BACKGROUND: Hip periprosthetic fractures (PPF) after total hip arthroplasty (THA) are becoming increasingly prevalent. Their management is secondary to the fracture type and the stability of the implant. This study aimed to provide the outcomes of operatively managed PPF from a high-volume centre to help guide future decision making.
METHODS: This was a retrospective study of prospectively collected data from January 2008 to January 2021. Patient demographics, implant specific details, and fixation strategy were collected. Complications including infection, reoperation, re-fracture, re-revision, were collected. Short-term mortality was evaluated at 3 months and 1 year. P-values <0.05 were considered significant.
RESULTS: 282 surgically managed PPF were identified. Vancouver B2 were predominant in 52% of the cases. Revision alone and revision with additional fixation were the most frequent strategies in 168 cases (60%). Complications requiring reoperation occurred in 20% of the cases, with infection as the most frequent (8.5%). Mortality rate was 7.8% at 3 months and 15.7% at 1 year, with significantly lower rates in B2 type. B2 fractures treated with cemented stems had a significantly lower 1-year mortality than distal fit revisions.
CONCLUSIONS: PPF is associated with a high complication rate. Revision alone and revision with additional fixation remain the preferred method in B2/B3 type fractures, however, cemented revision can yield similar outcomes with lower short-term mortality. Considering the high-risk elderly and frail category of patients, a multidisciplinary team is necessary to improve outcomes and reduce mortality.
Participants will undergo leukapheresis to isolate peripheral blood mononuclear cells to manufacture SYS6020 injection, during which no lymphodepleting chemotherapy will be performed. Participants receive 3 doses of SYS6020 injection, with a dose level of 1.8\*107CAR+ T-cells per kg. If one DLT occurs in three participants, additional 3 ones may be considered to be enrolled after SMC safety data review and make a determination.
Adherence to physical activity in older adults and those in a low-intensity rehabilitation program is important with respect to achieving the demonstrated benefits in mobility, physical function and overall health maintenance. Physical activities that incorporate motivational strategies can improve long-term adherence to therapy programs. The jDome BikeAround technology is one example, as it involves reminiscence therapy coupled with stationary bicycling. Participant's are able to visit any familiar locations or places they have wished to visit, thus providing a positive and interactive experience as they engage in physical activity.

Participants will be enrolled for a total of 12 weeks. They will have three 10 minute weekly sessions with the jDome BikeAround during their regularly scheduled therapy sessions. Feasibility will be evaluated by participant recruitment, program completion, rate of adverse events and staff acceptance.
The invention provides a traditional Chinese medicine for treating cancers. The traditional Chinese medicine comprises, by mass, 12-14 parts of Caulis Spatholobi, 11-13 parts of Berchemia floribun-da(Wall.) Brongn., 7-9 parts of Polygonum chinense, 12-14 parts of cernuous clubmoss herb, 12-14 parts of dried stem of Premna fulva Craib, 9-11 parts of Root of Whitebackleaf Mallotus, 6-8 parts of Root of Cherokee Rose, 6-8 parts of Siberian Cocklour Fruit, 9-11 parts of Herb of Sharpfruit Calanthodes, 14-16 parts of Phymatopsis hastata, 14-16 parts of Fuchsia hybrida Hort. ex Sieb. et Voss, 14-16 parts of Herb of Triquetrous Tadehagi, 9-11 parts of Eucommia ulmoides, 17-19 parts of Cratoxylum cochinchinense, 6-8 parts of Radix Fici Simplicissimae, 6-8 parts of Cissus pteroclada Hayata, 22-24 parts of Solanum lyratum Thunb, 6-8 parts of Root of Clark Clematis, 9-11 parts of Dictamnus dasycarpus, 4-6 parts of stem of Alsophila spinulosa, 4-6 parts of Kadsura Pepper Stem and 11-13 parts of Rhizoma Polygoni Cuspidati. The invention also discloses a preparation method of the traditional Chinese medicine. The method is characterized in that water is added to above traditional Chinese medicines, and stewing is carried out for 170-190min to obtain a soup, and the soup is taken within one day. The traditional Chinese medicine prepared through the preparation method according to above formula can effectively mitigate illness of cancer patients, and controls disease conditions.
All the sites showing a residual pocket in a sextant allocated to surgery group will receive flap surgery. After the administration of oral local anaesthesia (Articaine 1:100000) an intrasulcular flap will be raised. In order to preserve interdental tissue the flaps will be designed accordingly the principles of papillary preservation flap. Toot root will be carefully debrided using both ultrasonic instruments and Grecey's curettes. Bone recontouring and ostectomy/osteoplasty will be avoided. Single simple sutures will be used to close the flap (Vicryl 5-0).
The invention discloses a composition with gastrodia elata as a main raw material and a preparation method thereof. The composition is prepared by a gastrodia elata extract, a pinellia ternate extract, a white atractylodes rhizome extract and lecithin by the mass ratio of 20:10:10:85-80:30:30:10. The gastrodia elata extract is whole gastrodia elata powder or a gastrodia elata ethanol extract of the medicinal part of the gastrodia elata, the white atractylodes rhizome extract is a white atractylodes rhizome ethanol extract of the medicinal parts of white atractylodes rhizomes, and the lecithin is egg yolk lecithin or soya bean lecithin. The gastrodia elata ethanol extract is obtained by using 72.6-78.9% volume concentration of ethyl alcohol to conduct reflux extraction on the whole gastrodia elata powder or the medicinal part of the gastrodia elata. The white atractylodes rhizome ethanol extract is obtained by using 77.2-86.9% volume concentration of ethyl alcohol to conduct reflux extraction on the medicinal parts of the white atractylodes rhizomes. The composition with the gastrodia elata as the main raw material further comprises pharmaceutical auxiliary materials or pharmaceutical carriers. The composition has the effects of eliminating phlegm, calming wind, tonifying spleen and clearing dampness, and the simple ad practical preparation method can be widely applied to large-scale production.
The present invention is directed to microbicidal compositions and methods of use thereof for preventing the transmission of or treating sexually transmitted infections and/or common vaginal infections, while minimizing disruptions to vaginal ecology. The microbicidal compositions of the present invention comprise the microbicidal agent bisabolol. In a further embodiment of the present invention, the microbicidal agent may comprise a combination of bisabolol and Ciclopirox Olamine. These compositions are preferably encapsulated in the form of a foam, cream, wash, gel, suppository, ovule, ointment, film, tablet, foaming tablet, tampon, vaginal spray, or aerosol. The concentration of microbicidal agent will vary depending on the base or carrier. Preferably the concentration will fall within the parameters of approximately 0.01% to approximately 50% by weight, more preferably between approximately 0.01% to approximately 28%, and most preferably between approximately 0.05% and approximately 2%. In a preferred embodiment, the base or carrier is a gel and the microbicidal agent concentration will preferably range from approximately 0.01% to approximately 5% by weight, and more preferably from approximately 0.05% to approximately 2% by weight.
The method for the complex treatment of schizophrenia with the continuous course and the suicidal behavior comprises the use of Clopixol with accompanying central electroanalgesia. The daily oral dose of Clopixol increases within the week by 2.0-10.0 mg up to the medium daily dose of 75 mg. The electroanalgesia is performed in 4 hours after the morning dose of Clopixol is taken. The alternate mode of relative pulse duration is followed. In the course of the treatment, the current is augmented from 0.8 to 1.2 mA, the pulse frequency û from 200 to 1000 Hz, the pulse duration û from 1.2 to 1.3 ms, the duration of the procedure û from 45 to 50 min. The overall course of the treatment comprises 15 daily sessions.
PROBLEM TO BE SOLVED: To obtain a gel composition which has a high sustained release property for a compound to be subjected to a sustained release and whose specific gravity can be adjusted to enhance a property for staying the compound in a stomach, by compounding the compound with a fat or fatty oil or a polysaccharide. SOLUTION: This gel composition contains (A) a compound (for example, metronidazole, omeprazole or bismuth) to be subjected to a sustained release, and (B) a fat or fatty oil such as olive oil, corn oil or sesame oil or (C) a polysaccharide such as chitosan. The gel composition, for example, an alginate gel composition, is prepared by dropwisely adding an aqueous sodium alginate solution containing the component A and the component B or C to the aqueous solution of a gelling agent such as calcium pantothenate to instantaneously form the gel. The gel composition can orally be administered into a human body. When the gel composition is used as a medicinal composition, about 200 mg of a medicine may be added to 2.5 g of a hydrogel. The above composition is useful for treating digestive diseases.
There are certain factors (i.e. alcohol, tobacco, decreased saliva production from radiation) that predispose patients with a history of head and neck cancer to have esophageal disease. Often, in the initial stages of the disease, patients do not have symptoms. However, the early detection of precancerous lesions or small cancers improves patients' chances of being cured. There is no direct data supporting the practice of screening patients with a history of head and neck cancer after treatment for esophageal disease if they are not experiencing symptoms. However, many argue that screening endoscopy is justified in high risk patients to detect early esophageal cancer or dysplasia at a curable state. We are, therefore, performing this study to determine the value of endoscopic screening of the esophagus after treatment for head and neck cancer in patients without symptoms.
Subsistence use of natural resources, including the subsistence harvesting of shellfish, is central to Native cultures throughout Alaska. Shellfish harvesting appears as a motif in form line artwork and is a part of the traditional food ways taught by the tribes of Southeast Alaska to their youth. Saxitoxin, a toxin detected in Southeast Alaska that causes paralytic shellfish poisoning (PSP), was named after the butter clam (Saxidomus gigantea), which is a traditional food staple. The culturally central consumption of non-commercial shellfish puts Alaska Native communities at elevated risk for PSP. A population-based survey in two communities in coastal Alaska found that 20% of Alaska Natives in their sample reported a history of PSP.

The Theory of Planned Behavior is a behavioral science framework that has been applied in numerous public health settings to understand why people pursue specific actions. The Theory of Planned Behavior has been applied to children's health and to poisoning prevention/ environmental health, but as far as the investigators are aware this is the first pediatric poisoning prevention application of this framework. The project's K12 programming has been developed with this framework in mind. For the middle school research program (this clinical trial), the investigators aim to measure the relevant constructs for a theory-based investigation into children's poisoning-related risk behaviors in a context that affirms safe practice of cultural traditions.