anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Provided are a dermatological composition for the treatment of pimple containing thiamphenicol and a therapeutic agent for pimple containing the same. The composition stably exerts excellent pimple treatment effect within a short time period without making adverse side effects. CONSTITUTION: A dermatological composition for the treatment of pimple comprises 0.001-5.00wt.% of thiamphenicol. The composition further comprises propylene glycol, glycerin, and a solvent. The solvent is selected from the group consisting of ethanol, methanol and isopropyl alcohol. A therapeutic agent for pimple containing the composition is formulated into cream, ointment, solution, or lotion.
The study was approved by the UCSF Committee on Human Research, and all participants gave informed consent. The depressed subjects began treatment with placebo for one week, followed by escitalopram for eight weeks (10 mg per day x 4 weeks, followed by 20 mg per day x 4 weeks, as tolerated) in a double-blind, fixed-order, within-subject cross-over manner. The depressed subjects and the psychiatric rater were unaware of the study design and the sequence and duration of treatments. Depressed and control subjects underwent venipuncture to obtain blood for assays. The controls underwent venipuncture once, and the depressed subjects had venipuncture just prior to beginning active escitalopram treatment and again after 8 weeks of escitalopram treatment. Blood was also collected at Weeks 4 and 8 of treatment in the depressed subjects for assay of citalopram and citalopram metabolites, to gauge medication compliance. Finally, depression severity and global clinical change were assessed in the depressed subjects at Baseline and at the end of Week 8 of escitalopram treatment.
Vitamin A plays a critical role in various biological functions, including vision, cellular differentiation, and immune regulation. However, accurately assessing its status, particularly in obese individuals, presents challenges due to potential alterations in metabolism and distribution. This study utilized Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) methodology to precisely measure serum vitamin A concentrations in population of UAE. The methodology's reliability and precision, as demonstrated through validation procedures, underscore its potential utility in clinical settings. Employing the Multiple Reaction Monitoring mode of positive ion electrospray ionization, the LC-MS/MS system achieves a limit of detection (LOD) of 0.48 ng/mL in serum, while adhering to FDA-US regulations for accuracy and compliance. A key aspect of this study was the application of LC-MS/MS to assess vitamin A status in an obese population within UAE. By employing a diverse cohort of 452 Emirati participants, including 277 individuals from a randomized controlled trial who were assessed at baseline and at 6th month, and 175 healthy individuals aged 18-82 assessed at baseline, this study explores the relationship between obesity and vitamin A levels, shedding light on potential implications for health and well-being. It was an observational study based on a new vitamin A method and participants were asked to eat vitamin A rich foods. The robust performance of the LC-MS/MS methodology positions it as a valuable tool for clinical research. By accurately quantifying vitamin A levels in human serum, this methodology opens avenues for advancing our understanding of vitamin A physiology and its implications for health, particularly in obese populations. In summary, this LC-MS/MS methodology presents a potent tool for clinical studies, providing reliable, specific, and robust detection of vitamin A in human serum, thus, opening a new frontier for advancing our understanding of vitamin A related physiology and health in the obese population.
Participants in this group will choose their own music to listen to for 30 minutes before each basketball training and performance test. This intervention will be conducted three times a week for 12 weeks. The goal is to determine the effect of self-selected music on mental energy, mental toughness, psychological skills, mindfulness, athletic identity, and sports performance.
Chronic inflammatory diseases are becoming a leading cause of death worldwide. Although such diseases appear to be clinically distinct, they share many similarities in genetic background and pathophysiological pathways. There is an interest in developing drugs that inhibit CD 95-mediated non-apoptotic signaling pathways. In particular, neutralizing anti-CD 95L monoclonal antibodies are particularly desirable. The present inventors provided a neutralizing anti-CD 95L monoclonal antibody (mAb) designated JQ3 (IgG 1 κ). In particular, neutralization of JQ3 was demonstrated because this homemade monoclonal antibody inhibited the CD 95-mediated apoptosis signaling pathway of the T cell line Jurkat more effectively than the NOK-1mAb monoclonal antibody. Interestingly, JQ3 was able to block CD95 mediated Ca  2+  responses in neutrophils (COVID patients and anti-neutrophil cytoplasmic autoantibody (ANCA) -associated vasculitis (AAV) patients) exposed to various inflammatory sera. Thus, the present invention relates to neutralizing anti-CD 95L monoclonal antibodies derived from JQ3.
BACKGROUND: Enhanced Recovery After Surgery (ERAS) programs have been widely adopted in bariatric surgery. However, not all patients are successfully managed in the ERAS setting and there is currently little way of predicting the patients who will deviate from the program. Early identification of these patients could allow for more tailored protocols to be implemented preoperatively to address the issues, thereby improving patient outcomes.
OBJECTIVES: The aim of this study was to elucidate the factors which preclude discharge by comparing patients who were successfully discharged by the end of the first postoperative day (POD 0/1) to those who stayed longer, including revisional surgery in this analysis.
SETTING: A tertiary, high-volume Bariatric Centre, United Kingdom.
METHODS: A retrospective analysis was performed of all patients undergoing bariatric surgery in a single centre in 1 year. Multivariate analyses compared patient and operative variables between patients who were discharged on POD 0/1 and those who stayed longer.
RESULTS: A total of 288 bariatric operations were performed: 78% of operations performed were laparoscopic Roux-en-Y gastric bypass; 22% laparoscopic sleeve gastrectomy. Of these cases, 13% were revisional operations. Four patients returned to theatre on the index admission. 81% of patients were discharged by POD 0/1. A re-presentation within 30 days was seen in 6% of patients. There was no significant difference in length of stay for the type of operation performed (P = .86). Patients who had a revisional procedure were not more likely to stay longer. Length of stay was also independent of age, BMI, and comorbidities. Caucasian patients were more likely to be discharged on POD 0/1 than those of other ethnicities (90% versus 78%; P = .02). Operations performed by trainee surgeons, under consultant supervision, were significantly more likely to be discharged on POD 0/1 (P = .03). However, a logistic regression analysis was unable to predict patients who had a prolonged stay.
CONCLUSIONS: Patient length of stay is independent of BMI, operation, and comorbidities and these factors do not need special consideration in ERAS pathways. Patients undergoing revisional procedures can be managed in the same way as those having primary procedures, with a routine POD 0/1 discharge. However, the impact of individual patient factors, and their interaction, is complex and cannot predict overstay.
The invention relates to a traditional Chinese medicine dropping pill for treating arthritis and a preparation method for the traditional Chinese medicine dropping pill. The traditional Chinese medicine dropping pill for treating the arthritis comprises the main drugs and a substrate, wherein the ratio of the main drugs to the substrate is (1:1)-(1:9) in parts by weight. The main drugs comprise nux vomica, scorpio, stiff silkworm, ephedra, rhizoma atractylodis, frankincense, myrrh, medicinal cyathula root, acanthopanax extract and liquorice. The preparation method for the traditional Chinese medicine dropping pill comprises the following steps of: firstly, mixing all main drugs to obtain a mixture; then, adding the mixture to the molten substrate; then, dropping the mixture of the main drugs and the substrate into condensate; and finally, drying to obtain the traditional Chinese medicine dropping pill. The traditional Chinese medicine dropping pill for treating the arthritis is low in cost and convenient in taking, convenient in carrying and has no toxic and side effects, and traditional Chinese medicine product preparation formulations for treating the arthritis are supplemented. Especially, the traditional Chinese medicine dropping pill also has the obvious advantages of rapid effect and high bioavailability.
BACKGROUND: Impact of preoperative infection on liver transplantation (LT) needs further investigation.
MATERIALS AND METHODS: From 1 January 2015 to 31 December 2022, 24 122 eligible patients receiving LT were enrolled from the China Liver Transplant Registry database. The outcomes of LT were compared after using the propensity score-matched analysis.
RESULTS: Compared to the noninfection group, patients in the infection group were more likely to have postoperative effusion, infection, abdominal bleeding, and biliary complications (all P <0.01), and they had shorter 30-day, 90-day survival, and overall survival (all P <0.01). Cox proportional hazards regression analysis revealed that MELD score and cold ischemia time were risk factors for the overall survival in the infection group (both P <0.05). Besides, compared to the nonpulmonary group, patients in the pulmonary group were more likely to have postoperative effusion and infection (both P <0.0001), and less likely to have postoperative abscess and early allograft dysfunction (both P <0.05). Patients in the nonabdominal group also had a higher proportion of postoperative infection than those in the abdominal group ( P <0.05). Furthermore, compared to the number=1 group, patients in the number ≥2 group were more prone to postoperative effusion and infection (both P <0.01), and they also had shorter 30-day and 90-day survival (both P <0.05).
CONCLUSION: Preoperative infection can result in a higher incidence of early postoperative complications and shorter survival in liver transplant recipients. The types and number of infection sites will also influence the prognosis of liver transplant recipients.
The purpose of this study is to see if using a medication called INFERGEN, can help get rid of the virus and/or can help the immune response to prevent the illness from getting worse in the lungs. We hope that INFERGEN will either prevent patients from getting worse and requiring intensive care or will decrease the time for which they will need intensive care.

The Interferon-alpha (also called Interferon-alphacon1 or IFN-alphacon1 or INFERGEN) is an immune molecule, which has been shown to work against different viruses (anti-viral). Interferon is the standard of treatment for patients with chronic (infection that has been there for a long time) hepatitis C (a virus which affects the liver over many years) by giving it for 6-12 months. It has also been used for a shorter time of up to 14 days, in a small study for patients with respiratory disease caused by SARS and seemed to help these patients get better more rapidly. It also has been shown to stop different Influenza viruses from growing in test tubes and in lung tissue. It has also been shown to decrease the immune response to prevent it from over-reacting to viruses.
PROBLEM TO BE SOLVED: To obtain the subject inhibitor having strong α-glucosidase inhibitory activity, being readily taken by making the inhibitor include a plant belonging to the family Compositae as an active ingredient. SOLUTION: This inhibitor contains a plant belonging to the family Compositae as an active ingredient. For example, chamomile, burdock, Chrysanthemum coronarium, seed of sunflower, etc., may be cited as the plant belonging to the family Compositae and chamomile is preferable. Though the plant belonging to the family Compositae is used in an ordinary state, further dried and powdered or ground in water into a slurried state and the slurried plant may show glucosidase inhibitory activity, an extract obtained by using water and/or an alcohol preferably provides stronger α-glucosidase inhibitory activity. An extract obtained by using a mixed solution of water and an alcohol is especially preferable. Ethanol is preferable as the alcohol. The weight ratio of water/the alcohol is preferably 1/100 to 100/1, more preferably 1/50 to 50/1.
After hematopoietic stem cell reinfusion, the patients begin to take hetrombopag orally 7.5mg/d, until the patients reach complete platelet response (CR, platelet count ≥50×109/L for 3 consecutive days without platelet transfusions for 7 consecutive days). The treatment will stop when patients accept 21 consecutive days of treatment or reach the discontinuation criteria.
The present invention provides a Pichia pastoris fermentation lysate filtrate, a preparation method therefor, and use thereof, and belongs to the technical field of cosmetic raw materials. Provided is a fermentation lysate filtrate prepared by using Pichia pastoris expressing recombinant collagen and performing fermentation. The fermentation lysate filtrate comprises total protein, recombinant collagen, polysaccharides, amino acids, and various vitamins. Pichia pastoris fermentation bacteria expressing recombinant human collagen are used for preparing cosmetic raw materials for the first time, so that the waste treatment pressure caused by yeast fermentation bacteria is reduced, and waste is turned into wealth. The preparation method for the Pichia pastoris fermentation lysate filtrate is a whole-process online and automatic preparation process, and the preparation process is rapid and efficient. Meanwhile, the breeding of harmful bacteria can be effectively controlled during the whole preparation process flow. The lysate filtrate has the effects of soothing skin, enhancing a skin micro-ecological barrier, controlling oil, screening sunlight, and the like at the same time, thereby widening the application range thereof in preparing cosmetics.
Nasal Continuous Airway Pressure (CPAP) or Heated humidified high-flow Air support with nasal cannula (HHHFNC) are among the most commonly used non-invasive respiratory support methods. The purpose of this prospective study was to compare vital findings, blood gas parameters, perfusion index (PI) and plethysmographic variability index (PVI) values in premature infants treated with less invasive surfactant administration (LISA) under HHHFNC or CPAP. This study was carried out in Hacettepe University Hospital NICU between January and December 2017. Premature newborns who were on noninvazive respiratory support and were diagnosed as RDS within first 72 hours of life, were taken into the study. Noninvasive respiratory support was provided with nasal CPAP or HHHNFC. Pulse oxymetry measurements were obtained before and 5th, 30th, 60th, 120th , 360th minutes, blood gas analysis was performed immediately before and 120th, 360th minutes after surfactant administration.

Post-hoc, one-way difference between two independent means (two groups) statistical analysis was used. Significance P \< 0.05; effect size 0.9; power (1-ß err prob) was found to be 82%.
Bupropion Hydrochloride Extended-release (SR) tablets are indicated for the treatment of major depressive disorder (MDD), as defined by the Diagnostic and Statistical Manual (DSM).

The efficacy of bupropion in the treatment of a major depressive episode was established in two 4-week controlled inpatient trials and one 6-week controlled outpatient trial of adult subjects with MDD [see Error! Hyperlink reference not valid.].

The efficacy of Bupropion Hydrochloride Extended-release (SR) tablets in maintaining an antidepressant response for up to 44 weeks following 8 weeks of acute treatment was demonstrated in a placebo-controlled trial [see Error! Hyperlink reference not valid.].
ABSTRACT.            PROCESSED ATLANTIC SEAWATER.            WATER has been called the most "ESSENTIAL NUTRIENT".          Since creation, the amount of water on this Planet has not changed. However,  our  supplies  of  clean  usable  water  is  limited,and Canadians and indeed all the peoples of the World, must learn to use Water more wisely!!          The Product, PROCESSED NORTH ATLANTIC SEAWATER, has an average Salinity of 3.5% All the elements known to man are dissolved in Sea Water. The  main substances are:- Chlorine, Calcium, Sodium, Sulphate, Magnesium and Potassium. Sodium Chlorine  accounts for about  85%  of  the  total.  Other  dissolved  solids  present   in significant amounts include Magnesium Chlorine, Magnesium Sulphate, Potassium Sulphate, Calcium Carbonate and Magnesium Bromide.          The therapeutic capabilities and advantages of SEAWATER have been known for many centuries. It has been, and is used as an eyewash, mouthwash, throat gargle, skin toner and wound antiseptic. One prime Worldwide example of these qualities is the DEAD SEA of the Nation of Israel.  For more than 4000 years,  visitors seeking rejuvenation and revitalization have sought the near magical cures and unusual health-giving qualities of the Dead Sea!! So named for it's extraordinarily high levels of salt and minerals, it has the distinction of being the saltiest body of water in the World!! The waters are laden with minerals; in fact they have 50 times more concentrated bromine and 15 times more Magnesium than the Atlantic Ocean!! Bromine relaxes the nervous system and magnesium tones and refreshes the skin. Seawater is soothing to body tissues and is "NATURE'S WAY" to clean and cure!! It is so basic that it goes back to the beginning of time, and MAN as well as all other life is supposed to have come from the sea!!
Patients with metastatic prostate adenocarcinoma will be enrolled in the study and will undergo two 68Ga-Prostate Specific Membrane Antigen- Positron Emission Tomography (PSMA-PET) scans within 24-48 hours. The difference between the two scans is that the radiotracer used in each scan will be produced with a different method (68Ga-PSMA-cyclotron and 68Ga-PSMA-generator produced). The first scan will occur after a baseline clinical evaluation, which will include a history, physical, and baseline lab draw. After each scan, blood draws will be obtained.

The purpose of this study is to evaluate equivalence of two processes to create 68Ga-HBED-PSMA and compare dosimetry, biodistribution and whole body excretion/ metabolism. Furthermore, the research team will perform dynamic analysis of the PET scans to investigate repeatability of whole-body 68Ga-PSMA-generator Ki Patlak imaging against that of conventional whole-body 68Ga-PSMA- SUV imaging and evaluate equivalence of whole-body 68Ga-PSMA Ki Patlak imaging between the two processes to create 68Ga-HBED-PSMA (68GA-PSMA-cyclotron vs. 68Ga-PSMA-generator). Patients will afterwards receive standard of care treatment and follow up imaging.
FIELD: medicine, pharmacy. SUBSTANCE: proliposomal powder has monophase discrete particles of biologically active component and lipid of lipids mixture and crystalline hydrophilic pharmacologically acceptable carrier also. Temperature transient point of lipids is below 37 C. Lipids are taken among natural and synthetic phosphoglycerolipids, sphingolipids and digalactosylglycero-lipids. Proliposomal powders are used for inhalation, they are stable under conditions of prolonged storage and provide high biological availability of active component. EFFECT: improved quality and properties of powders. 41 cl, 4 ex
A connection apparatus and associated method are provided. The connection apparatus is configured to be connected to a guide line and a conduit so that the conduit can be pulled through a structure by the guide line. In this regard, the apparatus can include a body member that extends between first and second ends and defines a connector for engaging the guide line and an engagement portion for engaging the conduit. In some cases, a second connector is provided to engage a cable, such as an electrical wire, that is disposed in the conduit. Thus, the apparatus can be used to pull the conduit by a leading end thereof, and the apparatus can additionally pull the cable through the structure with the conduit, i.e., without requiring separate operations. The body member can also define a tapered outer contour, such as a frustoconical shaped end, to facilitate the passage of the apparatus and conduit through the structure.
BACKGROUND: An unintended dural tear (DT) is the most common intraoperative complication of lumbar spine surgery. The unilateral biportal endoscopic technique (UBE) has become increasingly popular for treating various degenerative diseases of the lumbar spine; however, the DT incidence and risk factors specific to UBE remain undetermined. Therefore, this study aimed to evaluate the incidence and risk factors of DTs in UBE.
METHOD: Data from all patients who underwent UBE for degenerative lumbar spinal diseases from November 2018 to December 2021 at our institution were used to assess the effects of demographics, diagnosis, and type of surgery on unintended DT risk.
RESULTS: Overall, 24/608 patients (3.95%) experienced DTs and were treated with primary suture repair or bed rest. Although several patients experienced mild symptoms of cerebrospinal fluid (CSF) leaks, no serious postoperative sequelae such as nerve root entrapment, meningitis, or intracranial hemorrhage occurred. Additionally, no significant correlations were identified between DT and sex (P = 0.882), body mass index (BMI) (P = 0.758), smoking status (P = 0.506), diabetes (P = 0.672), hypertension (P = 0.187), or surgeon experience (P = 0.442). However, older patients were more likely to experience DT than younger patients (P = 0.034), and patients with lumbar spinal stenosis (LSS) were more likely to experience DT than patients with lumbar disc herniation (LDH) (P = 0.035). Additionally, DT was more common in revision versus primary surgery (P < 0.0001) and in unilateral laminotomy with bilateral decompression (ULBD) versus unilateral decompression (P = 0.031). Univariate logistic regression analysis revealed that age, LSS, ULBD, and revision surgery were significant risk factors for DT.
CONCLUSIONS: In this UBE cohort, we found that the incidence of DT was 3.95%. Additionally, older age, LSS, ULBD, and revision surgery significantly increased the risk of DT in UBE surgery.