anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a health-care wine prepared by using 500g of 38 DEG high-quality distillate spirit, 2g of prepared rehmannia, 0.5g of lohanguo siraitia fruit, 0.2g of salvia miltiorrhiza, 0.6g of codonopsis pilosula, 0.1g of Mongolian milkvetch root, and 1g of tangerine peel. The six-medicine rehmannia is advantaged in sweet taste, cool characteristic, and no toxicity, and has functions of kidney tonifying, lung tonifying, heart tonifying, liver tonifying, blood nourishing, nerve soothing, spleen and stomach weakness treating, miscarriage preventing, blood tonifying, heat clearing, blood cooling, internal organ tonifying, essence and blood improving, eye and ear benefiting, blood vessel unblocking, kidney water nourishing, and yin nourishing. When the wine is taken for a long time, effects of weight reducing, aging resisting, and life preserving are achieved. The wine has functions of heat clearing, blood cooling, body fluid regenerating, cough relieving, intestine moistening, detoxifying, skin rejuvenating, beautifying, lung moistening, phlegm eliminating, blood sugar reducing, aging resisting, blood fat reducing, and weight reducing. The wine is sealed and stored for 20 days in a ceramic jar. When the win is taken, green onions, garlic, radish, and various bloods can not be eaten because the foods make Rong and Wei depleted and hair whitened. The wine cannot be hold by using steel and iron vessels.
Participants are going to discuss their experiences of long term pain. The discussions is supervised by a heath care professional and is based on beforehand defined subjects, i.e. relations, spare time, economics, occupation. The meetings are hold for 7 weeks, 2 hours a week.
Safety evaluation of a product in a market is like a moving ball which need re-evaluation as the data gather in its life cycle.(1) As per the definition of International society of harmonization and World Health Organization, adverse reaction is Adverse drug reaction (ADR) is defined as "A response to a drug which is noxious and unintended and which occurs at doses normally used in man for prophylaxis, diagnosis, or therapy of disease or for modification of physiological function." (2) Adverse reaction and adverse event are interchangeable use in pharmacovigilance sector by knowing the difference is that ADR term used when drug is causing the effect (1). The frequency of ADR is getting higher due to the increasing prevalence of chronic disease with the growing trend of combination drugs (3). The non-profitable organization of pharmacovigilance is playing tremendous role in disseminating the awareness of proper usage of drug globally.(3) According to Uppsala database statistics, approximately 3 million reports were listed as suspected ADRs. (4) Nearly 6.7% of hospitalizations were due to serious ADRs (5)
Atopic dermatitis (atopic eczema, AD) is a common skin inflammatory disease, dry skin and itchy skin is a significant symptom of most AD, often accompany patients for life, seriously affecting the physical and mental health and work life of patients. The number of AD patients is increasing worldwide, while the prevalence rate in China has increased more significantly in the past 10 years. It is characterized by persistent skin dryness and a reduced function of the skin as a barrier to the external environment. Encourage the free use of moisturizers (emollients) as a baseline treatment for AD and add anti-inflammatory therapy as needed. Currently, topical corticosteroids are still the first-line treatment options. However, studies have confirmed that patients with AD are cautious about the use of topical corticosteroids. Maintaining the humidity of the skin and restoring the barrier function of the skin is the basis of the treatment of atopic dermatitis. And studies have shown that regular use of emollients can improve skin hydration, restore the skin barrier, reduce the frequency of attacks, and reduce the use of topical corticosteroids. In patients with AD, daily use of moisturizing emollients enhances the response to topical corticosteroid therapy, reduce percutaneous water loss (TEWL), restore the skin barrier and promote hydration, and can prevent or reduce AD attacks by improving the associated skin barrier defects, prolonging the time between AD episodes. The purpose of this study is to see whether emollients have sustained improvement on the clinical severity of adult atopic dermatitis in maintenance phase.
Bola-amphiphile or bola-form cpds. having a hydrophobic straight or branched carbon chain at the ends of which are attached two hydrophilic heads, have the general formula R-A-E-Y. E = a carbon chain opt. interrupted by one or more aromatic, heterocyclic or functional gp.; A = a functional gp.; R = the residue of a reducing glucide having a linear or cyclised chain, or a deriv. of this, attached to A directly or indirectly through one of its aldehyde or ketone functions, or a deriv. of these; Y = a hydrophilic head which is an anionic gp. selected from carboxylate, sulphate, phosphate, sulphonate and phosphonate ions, directly or indirectly attached to the carbon chain E.
The pig circular ring virus 2 type (PVC2) inactivated vaccine (SH individual plant) of the invention belongs to biotechnology field. The pig circular ring virus 2 type poisonous individual plant SH belongs to circular ring virus section circular ring virus genus which has been preserved in Wuhan institute of virology, Chinese academy of sciences. The shanghai separated individual plant SH of purified PCV2 virus is obtained by gathering raw material from hogpen which happened bad weaning piglet multisystem exhaustion failure syndrome in Shanghai in 2002 year, separating, appraising and purifying virus. The PCV2-SH plant is proliferated in mass in PK-15 cell, inactivated through methyl aldehyde and emulsified with liquid paraffine adjuvant to prepare conventional liquid paraffin(e) adjuvant immunomodulators for vaccines. The laboratory has trial-manufactured five lots vaccines successfully which are good safety and also can induce pig bring immune protection effect, made out a draft rules for vaccines production and testing. The inactivated vaccine proved by every aspects experiment has met state biological products standard completely.
Patients undergo placement of a standard pleural chest tube. Within 36 hours of chest tube placement, patients undergo pleurodesis comprising intrapleural administration of talc slurry once followed by clamping of the chest tube for 2 hours while different patient positions are used to distribute the talc. The chest tube is then unclamped to allow continuous drainage. When the chest tube drainage is less than 150 mL over 24 hours, pleurodesis is assumed and the chest tube is removed.
PURPOSE:To obtain easily an immunoglobulin against microorganisms of swine, by cultivating a fused cell prepared from a cell system deficient in hypoxanthine.guanine.phosphoribosyl.transferase derived from a swine lymphoma and an antibody-forming cell. CONSTITUTION:For example, a cell containing IgM class receptor established from a swine lymphoma is subjected to stepwise increasing addition culture of 8-azaguanine, to give a cell system deficient in hypoxanthine.guanine.phosphoribosyl.transferase. The cell system as a parent cell is fused with an antibody- forming cell to give an antibody-forming fused cell, this cell is cultivated, immunoglobulin is formed, and recovered. The fusion is carried out in the presence of DMSO with PEG by a conventional procedure. A monoclonal antibody against a living organism such as microorganisms making a swine as a natural host, etc. can be prepared easily.
One-time Inhalation of Salbutamol 200 µg, Salmeterol 50µg and Fluticasone 500µg. During two bronchoscopic procedures two pre-specified lung tissue sites (middle lobe and lingula) will be sampled. Bronchoadsorption sample, bronchial brushing, mucosal biopsy, and bronchoalveolar lavage (BAL) samples will be taken from each site.
INTRODUCTION AND AIM: Status epilepticus (SE) in children is a critical condition that can be life-threatening. The objective of this study was to identify factors associated with the occurrence of SE after a first convulsive seizure in children.
METHODS: A retrospective study was conducted at the pediatric department of BEN AROUS regional hospital between January 2015 and December 2019.
RESULTS: A total of 300 patients admitted for a first epileptic seizure were included in this analysis. The mean age of the patients was 33 months. Seizures were generalized in 92.7%, with tonic-clonic seizures being the most common (54.8%). SE was diagnosed as inaugural in 29% of cases. Abnormalities in EEG were observed in 36.5% of cases, while MRI revealed abnormal results in 32.8% of patients. Factors associated with a risk of SE recurrence were age younger than 1 year (p = 0.003), neuromotor retardation (p = 0.001), EEG abnormalities (p < 0.001), MRI abnormalities (p = 0.001), and abrupte discontinuation of antiepileptic treatment (p < 0.001). Simple febrile seizure was identified as a protective factor (p = 0.038).
CONCLUSION: The study identified that age under 1 year, neuromotor delay, and abnormalities in EEG and MRI are significant risk factors for the recurrence of status epilepticus after a first epileptic seizure in children. These findings suggest targeted preventive strategies to improve the management and prognosis of these patients.
Periodontal disease or periodontitis is a common chronic infection and inflammatory gingival disease and its supportive tissue associated with several unwanted effects, including serious obstetric consequences. Periodontitis is commonly diagnosed in clinical practice based on clinical findings and radiological examinations, but also with the help of microbiological or periodontal bacterial specimens. Several salivary markers have been investigated and it appears that the determination of matrix metalloproteinases provides clear information on the difference between gingivitis, periodontitis, and healthy periodontitis. Especially in this respect, matrix metalloproteinase 8 (MMP 8) was investigated, which proved to be a fairly good marker. Little is known about the effect of periodontitis on reproductive potential of women. Some studies have assumed that periodontitis could be one of the possible risk factors of infertility of an unknown cause. One of the possible mechanisms responsible for the negative influence of periodontitis is the conception of the mediator of inflammation at the level of the endometrium and the place of implantation of the embryo.The aim of the study was to compare the level of MMP8 in salivary fluid in infertile patients in relation to the control group of fertile women, depending on the existence of periodontitis.
The invention discloses a neutralizing antibody or antigen binding portion thereof for resisting SARS-CoV-2 and application thereof. The neutralizing antibody against SARS-CoV-2 or antigen binding portion thereof comprises a heavy chain variable region designated by the name VH and a light chain variable region designated by the name VL, both VH and VL consisting of a determinant complementary region and a framework region; the determinant complementary regions of VH and VL are each composed of CDR1, CDR2 and CDR 3; the amino acid sequence of CDR1 of VH is shown as 26-33 positions in SEQ ID No. 3; the amino acid sequence of CDR2 of VH is shown as 51-57 in SEQ ID No. 3; the amino acid sequence of CDR3 of VH is shown as 96-106 th position in SEQ ID No. 3; the amino acid sequence of CDR1 of VL is shown as 27-32 positions in SEQ ID No. 4; the amino acid sequence of CDR2 of VL is shown as 50-52 th positions in SEQ ID No. 4; the amino acid sequence of CDR3 of VL is shown at positions 89-99 of SEQ ID No. 4. The neutralizing antibody has high neutralizing activity and can neutralize variant strain of SARS-CoV-2 in broad spectrum.
Provided herein is a recombinant polypeptide comprising a polypeptide for preventing or reducing interaction between human proteins EAG2 and kvβ2 and a cell penetrating peptide. The polypeptide may comprise a portion of Kvβ2 from or encompassing a region important for the interaction between two proteins, e.g. a contiguous portion of human Kvβ2 (SEQ ID NO: 26) encompassing at least amino acids 90 to 114 thereof. Reverse-reverse polypeptides based on such recombinant polypeptides are also described. The EAG2-kvβ2 complex is identified herein as a therapeutic target for certain cancers. Also disclosed herein are therapeutic uses of the recombinant polypeptides in the treatment of such cancers, including gliomas, such as lower gliomas or glioblastomas, which may be recurrent and/or resistant to conventional therapies.
Oral Miltefosine 2,5mg/kg/day up to 50mg 2x/daily. Oral Pentoxifylline 400mg 3x/daily for 28 days.
PURPOSE: A fatty acid-conjugated superoxide dismutase derivative which improves skin condition is provided to ensure anti-oxidation, to suppress inflammation and skin troubles such as acne, and to effectively improve skin condition. CONSTITUTION: A superoxide dismutase derivative is conjugated with saturated fatty acid. The N-terminal of the superoxide dismutase is conjugated with a carboxylic group of the saturated fatty acid. The saturated fatty acid is C8-C12 saturated fatty acid. A cosmetic composition for improving skin condition contains the superoxide dismutase derivative. The improvement of skin condition includes the treatment of skin inflammation or acne. An antibacterial cosmetic composition contains the superoxide dismutase derivative.
A non-finger scent frog insuline releasing stimulating peptide and use in pharmacy are disclosed. The stimulating peptide is prepared by separating from non-finger scent frog skin secretory liquid, purifying, determining its sequence and synthesizing polypeptide. It belongs to a single-chain polypeptide with molecular weight 2632.3 and isoelectric point 10.32. Polypeptide total sequence is phenylalanine-leucine-proline-leucine-lecucine-lactamic acid-glycine-leucine-lactamic acid-lactamic acid-agedoite-phenylalanine-leucine-proline-lysine-leucine-phenylalanine-cystecoside acid-lysine-isoleucine-threonine-arginine-lysine-glycine. It can improve insuline release, has excellent hemolytic and plasma clotting activities. It can be used to treat diabetes.
Academic performance plays a crucial role in long-term educational attainment and occupational function. Chronotype refers to an individual's daily tendencies for times for waking, activity, and sleep. Social jetlag reflects the mismatch between an individual's chronotype and their social schedule. Because school typically starts early in the morning, later chronotype is often associated with daytime sleepiness, insufficient sleep, and poor academic performance. However, the relationship between academic performance, chronotype, and social jetlag has not been extensively examined in large samples like the Adolescent Brain Cognitive Development (ABCD) study. We hypothesized that greater social jetlag would predict poorer cognitive and academic performance. Year 2 (ages 11-14) cross-sectional data from the ABCD cohort (n = 6,890 adolescents) were used to evaluate academic performance (i.e. self-reported past year grades), NIH Toolbox cognitive performance measures, chronotype, and social jetlag from the Munich Chronotype Questionnaire. We found that later chronotype and greater social jetlag predicted poorer cognitive and academic performance with small effect sizes. Our findings emphasize the importance of individual differences in chronotype and social jetlag when designing class schedules, as aligning school activities with student optimal sleep-wake times may contribute to improved academic performance.
INTRODUCTION: The present study was conducted with the aim of evaluating the accuracy of International Classification of Disease Perinatal Mortality (ICD-PM) codes assigned on death certificates before and after an expert panel review.
METHOD: The present study was a mixed methods observational study conducted at Umm al-Benin Hospital, the sole specialized obstetrics and gynecology center affiliated with Mashhad University of Medical Sciences. The study comprised three distinct stages: (1) Collecting primary ICD-PM codes assigned to perinatal death certificates, along with other relevant information, from October 2021 to March 2022; (2) Examining the circumstances of each perinatal death case and re-identifying the causes of death through a consensus process involving a panel of experts comprising pediatricians, obstetrics and gynecology specialists, and nursing and midwifery experts; presenting the new ICD-PM code; (3) Comparing the ICD-PM codes assigned to perinatal death certificates before and after the expert panel's evaluation.
RESULT: During the study period, a total of seven specialized panels were conducted to examine perinatal deaths. Out of the 71 cases, 41 were carefully reviewed by experts. These cases included 32 stillbirths and nine neonatal deaths. The examination process followed specific inclusion and exclusion criteria. The findings revealed that there were no significant changes in the causes of neonatal deaths. However, it was notable that 80% of the previously unknown causes of stillbirths were successfully identified. Notably, the occurrence of stillbirths increased by 78% due to maternal causes and conditions.
CONCLUSION: Convening panels of experts to discuss the causes of perinatal deaths can effectively reduce the percentage of unknown causes, as classified by ICD-PM. This approach also guarantees the availability of essential data for implementing effective interventions to decrease preventable perinatal deaths.
The invention discloses a recombinant arginine deiminase mutant, a preparation method and application thereof. The invention modifies the recombinant arginine deiminase gene (the amino acid sequence is shown as SEQ ID NO. 1) through directed evolution, screens beneficial mutations from 2 ten thousand clones, and further obtains an optimal mutant M15 through combined mutation. The amino acid sequence of the optimal mutant M15 is shown in SEQ ID NO. 3. The enzyme activity of the recombinant arginine deiminase mutant prepared by the invention is greatly improved, and the catalytic efficiency is greatly increased. Can be used for preparing anti-tumor (anti-hepatocarcinoma, melanoma, and prostatic cancer) medicines.
PURPOSE:The titled composition containing a crude drug extract having an antioxidizing ability. CONSTITUTION:An inhibitor composition for in vivo lipoperoxide formation containing a crude drug extract prepared by extracting a crude drug, e.g. allspice, rosemary, sage, paprika, pepper, cinnamon, clove, coriander, fennel, garlic, ginger, etc. with a solvent, e.g. ethanol, acetone, n-hexane, water or liquid edible fat or oil. The resultant composition can be formulated into a pharmaceutical by mixing a drug, e.g. tocopherol, ascorbic acid or glutathione, regarded as improving abnormality in in vivo lipoperoxide and a required excipient, etc. therewith. The dosage form is preferably an oral pharmaceutical, e.g. tablet, pill or drink, but can be administered as a parenteral pharmaceutical to expect local effect. The dose thereof is 1-100mg/kg.
The present invention discloses a medicine for treating stomatopathy and throat diseases and a preparation method thereof. The medicine is characterized in that the medicine is in a powder form and comprises the following components by weight: 35% to 50% of calcined gypsum, 10% to 20% of licorice, 1% to 5% of charred common rush, 2% to 8% of artificial bezoar, 2% to 8% of borneol, 5% to 15% of natural indigo, 1% to 6% of cinnabar, 5% to 15% of pearl, 1% to 6% of urine sediment and 2% to 8% of borax. The medicine is suitable for pharyngolaryngitis, tonsillitis, oral mucosa diseases, gingivitis, etc. and has the advantages of strong astringent capacity, high therapeutic effect and short course of treatment. The medicine can relieve intense pain caused by diabrotic oral mucosa ulcer for a moment and rapidly heal oral mucosa ulcer failing to close within a plurality of days. The medicine has no toxic or side effect, sufficient medicine sources, low cost and convenient and safe use.
PURPOSE:To provide the titled agent useful for the normalization of the microbial flora in vagina and the humectation and lubrication of vagina, by using whey or its treated material as an active component. CONSTITUTION:The agent contains whey or its treated material as an active component. The bacteria in the vagina are composed mostly of doederlein vaginal bacili having the physiological protective mechanism and the self-cleaning activity to protect the upper genitalia from infection with bacteria; however, the microbial flora in the vagina sometimes becomes to an undesirable state after menopause, etc. Further, a mucous liquid is secreted in the vagina generally by the effective sexual stimulus to facilitate the coitus; however, one may feel the difficulty, etc. in the coitus by the insufficient secretion caused by various external conditions and age, etc. It has been found that whey is effective for the normalization of the microbial flora in the vagina and the humectation and lubrication of the vagina. The whey includes any wheys such as the one obtained by adding an acid to milk, and separating the coagulated product. The prepared whey is absorbed in a tampon, and used as an insertion agent.
Human T-cell Lymphotropic Virus Type 1 (HTLV-1) is traditionally linked to severe conditions such as adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy, and HTLV-1 uveitis, with vertical transmission, particularly mother to child thorough breastfeeding, considered the primary route. Despite efforts to reduce vertical transmission through antenatal screening in Japan, horizontal transmission has contributed to the rising prevalence of HTLV-1 in metropolitan areas. This case reports the youngest documented instance of HTLV-1 uveitis resulting from horizontal transmission through sexual contact in an 18-year-old woman. The patient presented with blurred vision in her right eye, and a comprehensive ophthalmologic examination identified vitreous opacity and retinal vasculitis. Serological tests confirmed HTLV-1 infection, with a proviral load of 2.66 copies per 100 peripheral blood mononuclear cells, measured by real-time PCR. A differential diagnosis confirmed HTLV-1 uveitis. Further family and partner investigations confirmed horizontal transmission, most likely through sexual contact. Over 6 years of follow-up, the patient experienced multiple recurrences of HTLV-1 uveitis and developed HTLV-1-associated keratopathy. This case highlights the potential for rapid disease progression with relatively low proviral loads and short latency, emphasizing the need for updated public health strategies for sexually active young populations.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely to traumatology and orthopaedics, and can be used for osteoporosis correction in treating ununited fractures and false joints. That is ensured by preacribing osteogenone daily from the 21st postoperative day according to the schedule: 6 tablets a day for three months. Then for the following three months, 3 tablets a day are taken. ^ EFFECT: method is easy to implement, provides reducing total length of treatment, prevents further on-therapy bone loss in an operated extremity, thereafter increasing mineral density enabling osteoporosis regression is observed. ^ 2 ex, 2 tbl, 4 dwg
Percutaneous release of A1 pulley release will be performed in the well-managed operation theater set up, using an 18 gauge hypodermic needle, after preparation of the skin and injection of 1ml 2% plain lidocaine. The proper location of the pulley will be defined using surface landmarks in each digit after waiting a few minutes to allow the anesthetic to take effect the 18 gauge needle will be longitudinally moved to keep the level of the needle parallel with the tendon grating sensation will be elucidated confirming the cut of pulley until there is no grating sensation felt and improvement of symptoms. A sterile dressing will be placed.