anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention generally provides devices and the supporting software that allows a therapist to interactively control the delivery of tactile BLS to a remotely located client during a therapy session. The unique advantage of this invention is that the therapist and client can be in different physical locations during treatment with tactile BLS. The therapist's device supports configuring parameters such as the start, stop, and number of tactile stimulations delivered to the client. The client's device receives the parameters and activates the bilateral stimulation sequences accordingly. Each device connects to the Internet and communicates with a cloud-based service to exchange commands and settings. With this invention, the therapist and the client are no longer required to be in the same location during a treatment session incorporating tactile BLS.
The invention discloses a Buddha essence lipidosome, a Buddha essence lipidosome gel, a preparation method and application thereof, and belongs to the technical field of medicines. The raw materials of the Buddha essence oil liposome comprise Buddha essence oil, lecithin and cholesterol. The preparation method of the Buddha essence liposome comprises the following steps: dissolving Buddha essential oil, lecithin and cholesterol in solvent, and steaming under reduced pressure to form lipid film on the wall; adding buffer solution to continue rotary evaporation to make the film fall off, and carrying out ultrasonic hydration; homogenizing under high pressure to obtain the final product. The invention relates to a Buddha essence lipidosome gel, which comprises the following raw materials: gel matrix, humectant, triethanolamine and Buddha essence liposome. The preparation method of the Buddha essence lipidosome gel comprises the following steps: adding gel matrix into Buddha essence oil liposome, swelling, homogenizing, adding propylene glycol and triethanolamine, adding water to specified amount, and stirring. The invention has definite curative effect on treating acne and is safe; improving the stability and water solubility of the essential oil and delaying the release time of the essential oil.
The psychological states of hunger and satiety play an important role in regulating human food intake. Several lines of evidence suggest that these states rely upon declarative learning and memory processes, which are based primarily in the medial temporal lobes (MTL). The MTL, and particularly the hippocampus, is unusual in that it is especially vulnerable to insult. Consequently, we examine here the impact on hunger and satiety of conditions that: (1) are central to ingestive behaviour and where there is evidence of MTL pathology (i.e., habitual consumption of a Western-style diet, obesity, and anorexia nervosa); and (2) where there is overwhelming evidence of MTL pathology, but where ingestive behaviour is not thought central (i.e., temporal lobe epilepsy and post-traumatic stress disorder). While for some of these conditions the evidence base is currently limited, the general conclusion is that MTL impairment is linked, sometimes strongly, to dysfunctional hunger and satiety. This focus on the MTL, and declarative learning and memory processes, has implications for the development of alternative treatment approaches for the regulation of appetite.
<P>PROBLEM TO BE SOLVED: To provide a system and method for providing an access to a clinical data over the Internet.  <P>SOLUTION: This system 10 is provided with a server, and a database 12 connected to the server. The database stores clinical data sets. The system is provided further with a thin client, a communication link between the server and the Internet, and a communication link between the thin client and the Internet. Software running on the server receives a request for one or more clinical data sets, acquires the requested clinical data sets, and transmits the clinical data sets to the thin client.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Students in the skill group will take one of the applications in the Skill Checklists (Breastfeeding Education Skill Check Form, Breast Care and Caregiving to Mothers with Breast Engorgement Skill Check Form, Breast Self-Examination (KKMM) Training Skill Check Form) within the scope of the "Women's Health and Diseases Nursing Course". Health education material was prepared in line with the skills they determined. The duration of training material preparation is determined as 1 week for each student. The health education material developed was prepared and presented by evaluating the reason, importance, awareness aspect and innovative perspective of the determined skill.
Patients with Burkitt's lymphoma, diffuse large B-cell lymphoma, follicular lymphoma and other mature B-lymphoma patients. Patients were randomly divided into two groups for PK blood collection. There were 12 blood sampling sites in each group.
Osteoarthritis (OA) is a common joint degenerative disease, and chondrocyte injury is the main pathological and physiological change. Ruscogenin (Rus), a bioactive compound isolated from Radix Ophiopogon japonicus, exhibits various pharmacological effects. The aim of this research was to test the role and mechanism of Rus on OA both in vivo and in vitro. Destabilized medial meniscus (DMM)-induced OA model was established in vivo and IL-1β-stimulated mouse chondrocytes was used to explore the role of Rus on OA in vitro. In vivo, Rus exhibited protective effects against DMM-induced OA model. Rus could inhibit MMP1 and MMP3 expression in OA mice. In vitro, IL-1β-induced inflammation and degradation of extracellular matrix were inhibited by Rus, as confirmed by the inhibition of PGE2, NO, MMP1, and MMP3 by Rus. Also, IL-1β-induced ferroptosis was suppressed by Rus, as confirmed by the inhibition of MDA, iron, and ROS, as well as the upregulation of GSH, GPX4, Ferritin, Nrf2, and SLC7A11 expression induced by Rus. Furthermore, the suppression of Rus on IL-1β-induced inflammation, MMPs production, and ferroptosis were reversed when Nrf2 was knockdown. In conclusion, Rus attenuated OA progression through inhibiting chondrocyte ferroptosis via Nrf2/SLC7A11/GPX4 signaling pathway.
PRCIS: The study identified risk factors for exfoliation glaucoma and recommended re-evaluating target intraocular pressure (IOP) after 5 visual fields to slow disease progression.
PURPOSE: This study aimed to establish risk factors for exfoliation glaucoma and determine the earliest time points for estimating disease progression.
PATIENTS: A total of 96 patients with newly diagnosed exfoliation glaucoma were included. Included patients were required to perform at least 7 visual field tests within a 3-year period (±3 months). All patients were treated at inclusion.
METHODS: This was a nonrandomized, prospective cohort study. The predictors measured included IOP, mean deviation (MD), and visual field index (VFI). Progression was assessed using the rate of progression based on MD, VFI, and "Guided Progression Analysis." Linear or logistic regression models were developed based on the variables studied. An analysis of variance was used to establish the earliest time point. At the earliest time point, the models were retested. The area under the receiver operating characteristic curve was calculated.
RESULTS: The general rate of progression of the cohort was -3.84 (±2.61) dB for the MD values and 9.66 (±6.25) % for the VFI values over 3 years. The IOP, MD, and VFI values at diagnosis were predictors of progression for both linear and logistic regression. Analysis of variance and post hoc Tukey test showed significant values at 24 months for MD and VFI. The area under the curve at 24 months showed significant values for MD and VFI.
CONCLUSIONS: The predictors studied (IOP, MD, and VFI) showed moderate accuracy at baseline but excellent predictive capacity at 24 months postdiagnosis. Re-evaluating the target IOP at 24 months can effectively slow down disease progression.
BACKGROUND: Invasive lung adenocarcinoma with MPP/SOL components has a poor prognosis and often shows a tendency to recurrence and metastasis. This poor prognosis may require adjustment of treatment strategies. Preoperative identification is essential for decision-making for subsequent treatment.
OBJECTIVE: This study aimed to preoperatively predict the probability of MPP/SOL components in lung adenocarcinomas by a comprehensive model that includes radiomics features, clinical characteristics, and serum tumor biomarkers.
DESIGN: A retrospective case control, diagnostic accuracy study.
METHODS: This study retrospectively recruited 273 patients (males: females, 130: 143; mean age ± standard deviation, 63.29 ± 10.03 years; range 21-83 years) who underwent resection of invasive lung adenocarcinoma. Sixty-one patients (22.3%) were diagnosed with lung adenocarcinoma with MPP/SOL components. Radiomic features were extracted from CT before surgery. Clinical, radiomic, and combined models were developed using the logistic regression algorithm. The clinical and radiomic signatures were integrated into a nomogram. The diagnostic performance of the models was evaluated using the area under the curve (AUC). Studies were scored according to the Radiomics Quality Score and Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis guidelines.
RESULTS: The radiomics model achieved the best AUC values of 0.858 and 0.822 in the training and test cohort, respectively. Tumor size (T_size), solid tumor size (ST_size), consolidation-to-tumor ratio (CTR), years of smoking, CYFRA 21-1, and squamous cell carcinoma antigen were used to construct the clinical model. The clinical model achieved AUC values of 0.741 and 0.705 in the training and test cohort, respectively. The nomogram showed higher AUCs of 0.894 and 0.843 in the training and test cohort, respectively.
CONCLUSION: This study has developed and validated a combined nomogram, a visual tool that integrates CT radiomics features with clinical indicators and serum tumor biomarkers. This innovative model facilitates the differentiation of micropapillary or solid components within lung adenocarcinoma and achieves a higher AUC, indicating superior predictive accuracy.
PROBLEM TO BE SOLVED: To obtain the subject new compound useful especially as an analgesic and free from side actions inherent to conventional analgesics. SOLUTION: The objective compound is expressed by the formula I (R<1> and R<2> are each H, a lower alkyl, etc.; R<3> is a lower alkyl or phenyl; R<4> is a hydroxy-lower alkyl, an oxo-lower alkyl, etc.), e.g. 2,6-dioxo-5-[methyl(4- methylphenyl)sulfoniol-1,2,3,6-tetrahydropyrimidin-4-olate. The compound can be produced e.g. by reacting a compound of the formula III with iodobenzene diacetate in the presence of an alkali such as sodium carbonate at 0 deg.C to room temperature for 1-10hr and reacting the resultant compound of the formula III with a thioether derivative of the formula R<3> -S-R<4> in a solvent such as methanol in the presence of an acid catalyst such as acetic acid at a temperature between room temperature and the refluxing temperature for 10 min to 30 hr.
Gastrointestinal track (GIT) including oesophageal and gastric cancers are a leading cause of cancer death worldwide. Limited therapeutic options highlight the need to understand the molecular changes responsible for the disease and to develop therapies based on this understanding. Advances in understanding the molecular changes responsible for GIT cancer etiology and progression are expected to improve disease diagnosis and treatment. The glutathione peroxidase 7 (GPX7) a candidate tumor suppressor implicated in GIT cancers including esophageal and gastric cancers has been implicated as a potential tumor suppressor gene in esophageal and gastric cancers; however, this claim is controversial. The goal of this invention is to develop cell-permeable (CP-) form of GPX7 to utilize the therapeutic potential of GPX7 in the treatment of GIT cancers. Using macromolecule intracellular transduction technology (MITT) enabled by novel hydrophobic cell-penetrating peptide (CPP) called advanced macromolecule transduction domains (aMTDs) which are able to promote protein uptake by mammalian cells and tissues, the first CP-GPX7 protein has been developed to deliver biologically active GPX7 protein into human oesophageal and gastric cancer cells, resulting in suppression of cell phenotypes and induction of changes in biomarker expression consistent with previously described effects of GPX7. CP-GPX7 recombinant protein fused to aMTD also suppresses the growth of human gastric tumors in a mouse xenograft model. The results of this art provide further evidence that GPX7 can function as an anti-cancer molecule and suggest that practical methods to augment GPX7 function could be useful in treating of some types of GIT cancers. The present art with CP-GPX7 recombinant protein illustrates the use of protein-based therapies to target GIT cancers.
PROBLEM TO BE SOLVED: To provide a molded part which has a surface having a sufficient hydrophilicity (biocompatibility) and a high durability and exerts no deterioration in the performance of the molded part. SOLUTION: A shaped matter (b), prepared by shaping into a given form a hydrophobic, photopolymerizable composition containing a hydrophobic compound (a) having two or more polymerizable unsaturated double bonds within one molecule and a photopolymerization initiator, is formed. The surface of the shaped matter (b) is brought into contact with a hydrophilic liquid (d) containing a compound (c) having a polymerizable unsaturated double bond, a quaternary amino group and a phosphate anion group. The shaped matter (b) in the above contact state is irradiated with an active ray to cure the shaped matter (b).  Furthermore, at the contact interface of the shaped matter (b) with the hydrophilic liquid (d), the hydrophobic compound (a) and the hydrophilic compound (c) are copolymerized to chemically bind the molecules of the hydrophilic compound (c) to the surface of the hydrophobic shaped matter (b). Here, photopolymerization reaction is not allowed to occur in the hydrophilic liquid (d) except at the above contact interface.
PURPOSE: Frailty was indicated to be closely related to older adults' lifestyles, especially in nutrition-related factors (such as balanced diet and oral functions), physical factors, and social factors in our previous study. Here, we developed an "Eleven-Check" (EC) questionnaire containing the aforementioned three factors. This study tested whether the EC questionnaire can estimate frailty in community-dwelling older adults.
MATERIALS AND METHODS: The study sample comprised 1,523 independent older adults. The primary outcome of frailty was assessed using the Cardiovascular Health Study index. The secondary outcome of sarcopenia was assessed by the criteria of the Asian Working Group for Sarcopenia 2019. The EC questionnaire comprised 11 dichotomous factors related to nutrition-related (diet and oral functions), physical, and social factors.
RESULTS: Frailty prevalence was 8.5 % (76.1 ± 5.8y, 45.1 % women). The accuracy of the EC questionnaire for frailty was optimal when the total scores of 4/5 were used as the threshold. Compared to the low-risk group (<5), the high-risk group (≥5) had a significant association between frailty with an adjusted odds ratio (aOR) of 4.68 (95 %CI, 3.10-7.05). Moreover, the high-risk group also had a significant association with sarcopenia, with an aOR of 1.82 (1.27-2.61).
CONCLUSIONS: For community-dwelling older adults, the EC questionnaire was able to simply screen frailty and sarcopenia status. Further, it might raise older adults' self-awareness from a multifaceted perspective in their daily life to prevent steady decline and frailty sustainably in a community setting.
PROBLEM TO BE SOLVED: To prepare a safe therapeutic agent for asthma, capable of suppressing the immediate type asthmatic and delayed type asthmatic reactions in bronchial asthma and having excellent suppressing effects on especially the delayed type asthmatic reaction and low toxicity. SOLUTION: This therapeutic agent for asthma comprises a compound of formula I or II [R<1> and R<2> are each H, a halogen, trifluoromethyl, nitro, a 1-6C alkyl, etc.; R<3> is an aryl, an aromatic heterocyclic ring, etc.; R<4> is H, OH, S-glutathione, an aralkyl, etc.; R<5> is H or a 1-6C alkyl; Y is O or S; (n) is 0-5, etc.] or its salt as an active ingredient. 2-Phenyl-1,2-benzisoselenazol-3(2H)-one is exemplified as the compound of formula I or II and can be prepared as a dosage form for peroral and parenteral administrations by further suitably blending the compound of formula I or II with a usually used additive. The daily dose thereof is 100-2000mg in the case of the peroral administration.
JENTADUETO

JENTADUETO contains: linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin, a biguanide.

Linagliptin

Linagliptin is an inhibitor of DPP-4, an enzyme that degrades the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Thus, linagliptin increases the concentrations of active incretin hormones, stimulating the release of insulin in a glucose-dependent manner and decreasing the levels of glucagon in the circulation. Both incretin hormones are involved in the physiological regulation of glucose homeostasis. Incretin hormones are secreted at a low basal level throughout the day and levels rise immediately after meal intake. GLP-1 and GIP increase insulin biosynthesis and secretion from pancreatic beta cells in the presence of normal and elevated blood glucose levels. Furthermore, GLP-1 also reduces glucagon secretion from pancreatic alpha cells, resulting in a reduction in hepatic glucose output.

Metformin HCl

Metformin is an antihyperglycemic agent which improves glucose tolerance in patients with type 2 diabetes mellitus, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and day-long plasma insulin response may decrease.
PROBLEM TO BE SOLVED: To encoffin a container storing makeup cosmetics for cremation by forming it with only a flammable raw material. SOLUTION: A tube container 1 and a sponge 3 stored in a paper box 5 are taken out, and a cosmetic substrate is fed to the sponge 3 from the tube container 1 and is applied to the whole face of a corpse. After the cosmetic substrate is uniformly applied to the whole face of the corpse, a compact container 2 is taken out, the foundation F stored in it is applied, and dressing is applied to the corpse with cheek rouge C and a lipstick L. The Lipstick L is applied with a lip brush 4. After the dressing to the corpse is completed, the compact container 2 is encoffined together with the corpse. Since the compact container 2 is wholly formed with a flammable raw material, e.g. an ABS resin, including the foundation F, cheek rouge C and an intermediate dish 6 for the lipstick L, it can be cremated together with the corpse, and no noxious substance is generated by cremation.
The face-to-face rehabilitation program combines pain science education with an active behavioral approach. First, 2-3 individual face-to-face sessions are organized with a physical therapist (recruited and trained by the research team) to provide pain science education. The content of this pain science education program is the same as for the eHealth program. Similar as in the eHealth program, this education intervention includes advice for activity management, while experiencing pain and other symptoms, in order to remove barriers for an active lifestyle. The educational information will be presented verbally (explanation by the therapist) and written (information leaflet, summaries, pictures, metaphors and diagrams on computer and paper). After the education, the physical therapist will discuss proper goal setting with the patient to reach an active lifestyle and will coach the participant to reach these goals with maximum 6 face-to-face sessions.
Group B streptococci (Streptococcus agalactiae) are found in the vaginal microbiota in 10-30% of women without showing signs of infection. However, during delivery, it can be transmitted to the baby and, although in most cases it does not lead to disease, in a percentage of 5% of babies it causes serious infections that can trigger the death of the baby. In order to avoid this risk, a protocol of intra-partum preventive administration of antibiotics was implanted decades ago in women with a positive vaginal culture for this species in the weeks before birth. Taking into account the high percentage of women who show positive culture, this represents a high percentage of women who receive preventive antibiotic treatment with the consequences that this has for the mother's and baby's microbiota, as well as contributing to the generation of antibiotic resistance, a serious problem for today's society.

The fecal microbiota is considered a source of bacteria for the vaginal microbiota. In fact, women who present S. agalactiae in the vaginal microbiota also have it in stool. Given the demonstrated ability of Lactobacillus to control certain bacterial populations, the ability of a battery of Lactobacillus strains to inhibit the growth of S. agalactiae in the context of the fecal microbiota was analyzed. From these tests the strain Lactobacillus BSL_PS71 was selected for its antibacterial capacity against S. agalactiae.
Background and Objective: Early discharge following robot-assisted kidney transplantation (RAKT) is a cost-effective strategy for reducing healthcare expenses while maintaining favorable short- and long-term prognoses. This study aims to identify predictors of postoperative delayed discharge in RAKT patients and develop a predictive model to enhance clinical outcomes. Materials and Methods: This retrospective study included 146 patients aged 18 years and older who underwent RAKT at a single tertiary medical center from August 2020 to January 2024. Data were collected on demographics, comorbidities, social and medical histories, preoperative labs, surgical information, intraoperative data, and postoperative outcomes. The primary outcome was delayed postoperative discharge (length of hospital stay > 7 days). Risk factors for delayed discharge were identified through univariate and multivariate regression analyses, leading to the development of a risk scoring system, the effectiveness of which was evaluated through receiver operating characteristic curve analysis. Results: 110 patients (74.8%) were discharged within 7 days post-transplant, while 36 (24.7%) remained hospitalized for 8 days or longer. Univariate and multivariate logistic regression analyses identified ABO incompatibility, BUN levels, anesthesia time, and vasodilator use as risk factors for delayed discharge. The RAKT score, incorporating these factors, demonstrated a predictive performance with a C-statistic of 0.789. Conclusions: This study identified risk factors for delayed discharge after RAKT and developed a promising risk scoring system for real-world clinical application, potentially improving postoperative outcome stratification in RAKT recipients.