anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Accumulating evidence indicates that aberrant non-SMC condensin II complex subunit D3 (NCAPD3) is associated with carcinogenesis of various cancers. Nevertheless, the biological role of NCAPD3 in the pathogenesis of non-small cell lung cancer (NSCLC) remains unclear.
METHODS: Immunohistochemistry and Western blot were performed to assess NCAPD3 expression in NSCLC tissues and cell lines. The ability of cell proliferation, invasion, and migration was evaluated by CCK-8 assays, EdU assays, Transwell assays, and scratch wound healing assays. Flow cytometry was performed to verify the cell cycle and apoptosis. RNA-sequence and rescue experiment were performed to reveal the underlying mechanisms.
RESULTS: The results showed that the expression of NCAPD3 was significantly elevated in NSCLC tissues. High NCAPD3 expression in NSCLC patients was substantially associated with a worse prognosis. Functionally, knockdown of NCAPD3 resulted in cell apoptosis and cell cycle arrest in NSCLC cells as well as a significant inhibition of proliferation, invasion, and migration. Furthermore, RNA-sequencing analysis suggested that NCAPD3 contributes to NSCLC carcinogenesis by regulating PI3K/Akt/FOXO4 pathway. Insulin-like growth factors-1 (IGF-1), an activator of PI3K/Akt signaling pathway, could reverse NCAPD3 silence-mediated proliferation inhibition and apoptosis in NSCLC cells.
CONCLUSION: NCAPD3 suppresses apoptosis and promotes cell proliferation via the PI3K/Akt/FOXO4 signaling pathway, suggesting a potential use for NCAPD3 inhibitors as NSCLC therapeutics.
Up to two-thirds of patients diagnosed with major depressive disorder (MDD) will not respond to standard pharmacological and psychological interventions and will be considered treatment resistant (TR-MDD). Decreased reactivity to positive stimuli, indexed by low amygdala reactivity to positive autobiographical memory recall, may be a causal mechanism interfering with recovery from TR-MDD. Previous work in our lab suggests that individuals who do respond to antidepressant medications show increased amygdala activity that is indistinguishable from controls relative to baseline, while TR-MDD individuals fail to show this increase in amygdala activity. Furthermore, the investigators have found that MDD participants (more generally, not specifically TR- MDD) are indeed able to increase their amygdala response during positive memory recall via real-time fMRI neurofeedback (rtfMRI-nf) training, and that this increase is associated with large and rapid reductions in depressive symptoms. Here, the investigators propose to evaluate whether rtfMRI-nf training to increase the amygdala response to positive memories may serve as an intervention for TR-MDD. 100 TR-MDD individuals will be randomly assigned under double-blind conditions to receive 5 amygdala rtfMRI-nf or 5 control rtfMRI-nf sessions where they are trained to regulate a parietal region putatively not involved in emotional processing or MDD. The investigators will assess changes in amygdala activity, severity of clinical symptoms, and autobiographical memory deficits. Success will suggest a new non- pharmacological, non-invasive intervention for a traditionally treatment-resistant population of MDD individuals.
The concept of liquid biopsy analysis has been established more than a decade ago. Since the establishment of the term, tremendous advances have been achieved and plenty of methods as well as analytes have been investigated in basic research as well in clinical trials. Liquid biopsy refers to a body fluid-based biopsy that is minimal-invasive, and most importantly, allows dense monitoring of tumor responses by sequential blood sampling. Blood is the most important analyte for liquid biopsy analyses, providing an easily accessible source for a plethora of cells, cell-derived products, free nucleic acids, proteins as well as vesicles. More than 12,000 publications are listed in PubMed as of today including the term liquid biopsy. In this manuscript, we critically review the current implications of liquid biopsy, with special focus on circulating tumor cells, and describe the hurdles that need to be addressed before liquid biopsy can be implemented in clinical standard of care guidelines.
The invention discloses a new method for detecting an abnormal body temperature sequence, and belongs to the field of intelligent medical treatment. For each user, sampling is firstly carried out at intervals of 30 minutes, and the average value of the body temperature data within 30 minutes is selected as a sampling result. And then all the sampling temperature values measured by each user in the sampling time period form a body temperature sequence of each user, body temperature data are preprocessed, invalid values are filtered out, and the data missing positions are filled by an interpolation algorithm to obtain a complete body temperature sequence. And marking the complete body temperature sequence according to the hospital detection result to obtain the label of each user. And finally, dividing the user data with the labels into a training set and a verification set according to a ten-fold cross validation mode, training the fully-connected neural network by using the training set, and performing validation by using the verification set. And predicting the infection condition corresponding to the body temperature sequence of the user to be detected by using the trained fully-connected neural network. The method has the advantages of more accurate judgment, simple and convenient operation and stronger flexibility.
Participants will be randomized to either the home hypnotherapy or educational group. The HHT protocol will consist of sequences of two different types of sessions, longer biweekly sessions (LS), each approximately 30-40 minutes in length, and shorter daily sessions (SS), approximately 12 minutes in length. On the first day of each sequence, the patient will listen to the appropriate LS. The patients will listen to the SS on a daily basis in between each LS. Every 2 weeks a new sequence will begin, for a total of 12 weeks of treatment.
An ultrasound system may include an ultrasound device that includes a first wired communication module and a first wireless communication module. The ultrasound system may further include a processing device that includes a second wired communication module and a second wireless communication module. The processing device may pair with the ultrasound device over a wireless connection using the first wireless communication module and the second wireless communication module. The processing device may further indicate a wireless connection on a display screen of the processing device. The processing device may further conduct an ultrasound imaging session over the wireless connection. The processing device may further determine that a cable has been connected between the ultrasound device and the processing device. The processing device may further terminate the wireless connection with the ultrasound device. The processing device may further indicate a wired connection on the display screen of the processing device.
Macrophages in the tumor microenvironment, termed tumor-associated macrophages (TAMs), promote the progression of various cancer types. However, many mechanisms related to tumor-stromal interactions in epithelial ovarian cancer (EOC) progression remain unclear. High-grade serous ovarian carcinoma (HGSOC) is the most malignant EOC subtype. Herein, immunohistochemistry was performed on 65 HGSOC tissue samples, revealing that patients with a higher infiltration of CD68+, CD163+, and CD204+ macrophages had a poorer prognosis. We subsequently established an indirect co-culture system between macrophages and EOC cells, including HGSOC cells. The co-cultured macrophages showed increased expression of the TAM markers CD163 and CD204, and the co-cultured EOC cells exhibited enhanced proliferation, migration, and invasion. Cytokine array analysis revealed higher YKL40 secretion in the indirect co-culture system. The addition of YKL40 increased proliferation, migration, and invasion via extracellular signal-regulated kinase (Erk) signaling in EOC cells. The knockdown of integrin β4, one of the YKL40 receptors, suppressed YKL40-induced proliferation, migration, and invasion, as well as Erk phosphorylation in some EOC cells. Database analysis showed that high-level expression of YKL40 and integrin β4 correlated with a poor prognosis in patients with serous ovarian carcinoma. Therefore, the YKL40/integrin β4 axis may play a role in ovarian cancer progression.
An implanted storage vessel for medicament is coupled to an implantable pump. Pump memory stores infusion dosage data. A port inputs a signal from the patient, prompting pumping action. The dose given is limited by the dosage data. The memory is programmed with dosage data. The patient self-administers medicament, but the dosage is limited by the dosage data stored, restricting the maximum dosage. An implanted storage vessel for medicament is coupled to an implantable pump. Pump memory stores infusion dosage data. A port inputs a signal from the patient, prompting pumping action. The dose given is limited by the dosage data. The memory is programmed with dosage data from outside the body of the patient. The patient self-administers medicament, but the dosage is limited by the dosage data stored, restricting the maximum dosage. Dosage data is prescribed by a separate individual. An Independent claim is included for the corresponding method of dosage control using a high frequency external signal to input the dosage data to memory.
Participants will receive Placebo for 24 weeks. Participants at the end of 24 weeks will have the option of participating in the 2-year Extension Period.
BACKGROUND Superior semicircular canal dehiscence is an inner-ear pathology which presents with vertigo, disequilibrium, and hearing loss. Although the exact etiology of superior semicircular canal dehiscence is unknown, it is thought that an increase in middle-ear pressure disrupts a thin overlying temporal bone. Superior semicircular canal dehiscence is frequently seen in association with dehiscence of the tegmen tympani, which overlies the middle ear. Here, we present a case report of a 52-year-old Puerto Rican man with vertigo, dizziness, vomiting, and mild hearing loss associated with superior semicircular canal and tegmen tympani dehiscence after performing improper scuba diving techniques. CASE REPORT A 52-year-old Puerto Rican man presented to the emergency department with vertigo, dizziness, vomiting, and mild hearing loss in the right ear. The symptoms began shortly after scuba diving with inadequate decompression techniques on ascent. He was treated with recompression therapy with mild but incomplete improvement in symptoms. Bilateral temporal magnetic resonance imaging was suggestive of segmental dehiscence of the right superior semicircular canal and tegmen tympani. High-resolution computed tomography of the temporal bone confirmed right superior semicircular canal and tegmen tympani dehiscence with an intact left inner ear. CONCLUSIONS The increased inner-ear pressure that occurs during scuba diving can lead to dehiscence of the superior semicircular canal and tegmen tympani, causing vertigo and hearing loss. Performance of improper diving techniques can further increase the risk of dehiscence. Therefore, appropriate radiologic evaluation of the inner ear should be performed in such patients.
Toothpastes containing 10-60 wt. % of polishing agents, 2-20 wt.  % of humectants, 0.5-5 wt. % of water-soluble consistency regulators and 0.05-0.5 wt. % of antimicrobial biguanides as well as 1-5 wt. % of other additives from the group of surface-active substances which contain aromatic oils and sweeteners, have a particularly high biguanide availability if the polishing agent consists main of calcium carbonate, the consistency regulators are non-ionic polysaccharide derivatives and the surface-active substances are a cationic tenside with a linear alkyl group containing 12-18 carbon atoms and one or two tertiary amino groups or quaternary ammonium groups and possibly a non-ionogenic solubilizer for the aromatic oil.
The present invention provides an optimized and/or enriched hydrolyzable tannoid blend derived from  Terminalia chebula . In an embodiment the present invention further relates to the use of an extract of  Terminalia chebula  for treatment of osteoarthritis. In another embodiment, a  T. chebula  extract composition contains about 8-25% by weight chebulagic acid, about 15-30% by weight chebulinic acid and about 10-40% by weight other low molecular weight hydrolyzable tannoids. This embodiment provides a  T. chebula  enriched tannoid blend composition (TC/enriched tannoid blend). In another embodiment, a method of treating osteoarthritis in an individual is provided, comprising administering to the individual in need thereof a therapeutically effective amount of the  T. chebula  extract composition. In yet another embodiment, a method of reducing pain and inflammation in an individual afflicted with osteoarthritis is provided, comprising orally administering to the individual in need thereof a therapeutically effective amount of the  T. chebula  extract composition.
Educational Intervention plus Decision Support - Physicians in the intervention arm received a practice-level and physician-level summary report via a secure web site designed for patients with treatment recommendations that were discordant with current therapy, along with an explanation for the recommendation, the gain or loss in QALYs predicted by the decision model and the current 2014 ACC/AHA/HRS guidelines. Providers were also reminded of upcoming visits for patients being seen within the next week so they could review their reports and use them in discussions with their patients.
Most often, viruses are the cause of pneumonia in children. However, viral pneumonias are frequently associated with secondary bacterial pneumonia. It is important, though difficult, to differentiate patients who only have viral pneumonia from those who have viral pneumonia with secondary bacterial pneumonia. This will help physicians to prescribe antibiotics to only those with bacterial pneumonia and avoid antibiotic use in those with pure viral pneumonia, thus help to limit health-care cost and to decrease emergence of antibiotic resistance. In adult studies, TREM-1 has been shown to be specifically expressed in bacterial infections.

We propose that measuring TREM-1 in the bronchoalveolar lavage (BAL) fluid will help to differentiate these groups. Our hypothesis is that concentration of TREM-1 will be significantly elevated in the BAL fluid of children with bacterial pneumonia and viral with co-existing bacterial pneumonia than in children with pure viral pneumonia.
Method for the preparation and isolation of 3,4-diaciloxy-alpha-/(methylamino) -metil/- bencilalcohol. Is to reactively reduce a salt of addition of acid of the corresponding amine that contains a function ceto with bodohidruro sodico or potasico in an acidic solution, preferently acetic acid. The addition salt is isolated from the compound (I) obtained by adding water to the mixture, extracting the salt with a chloride hydrocarbon, such as chloroform or methylene chloride. The reaction temperature rocks between 0 and 50ºc. The solution in chloride hydrocarbon obtained after the reaction mass, first washed with an alkaline solution and then it is treated with diluted chlorhydride. R is a rent or architect. (Machine-translation by Google Translate, not legally binding)
The present invention relates to identification of a gene upregulated by interferon-α administration corresponding to the cDNA sequence set forth in SEQ. ID. NO. 1. Determination of expression products of this gene is proposed as having utility in predicting responsiveness to treatment with interferon-α and other interferons which act at the Type 1 interferon receptor. Therapeutic use of the protein encoded by the same gene is also envisaged.
Hamstring strains are increasingly common in sports, particularly in football and professional basketball, where they are the fourth most frequent injury. Stretching, especially when combined with techniques like proprioceptive neuromuscular facilitation (PNF), is a key method used to reduce the risk of these injuries. PNF, which involves alternating stretches with muscle contractions, is widely regarded for improving muscle flexibility. Recently, stretching combined with neuromuscular electrical stimulation (NMES) has also shown promise for increasing flexibility. A variant of PNF called contract-relax PNF (crPNF) has been proposed, where NMES is applied during the contraction phase to further enhance flexibility gains. However, there are no studies on the short-term effects of crPNF and crPNF + NMES in young male basketball players, a group known for higher degrees of hamstring shortening.

This study aims to compare the short-term effects of crPNF and crPNF + NMES on hamstring flexibility in young male basketball players and assess whether one technique is superior to the other. A secondary goal is to determine if either stretching protocol negatively impacts vertical jump ability, an important skill in basketball.
BACKGROUND: Individuals with spinal cord injury (SCI) often suffer from neuropathic pain which is often disabling and negatively affects function, participation, and quality of life (QoL). Pharmacological treatments lack efficacy in neuropathic pain reduction hence studying alternatives to drug treatment is necessary. Preclinical evidence of various aerobic exercises has shown positive effects on neuropathic pain but scientific studies investigating its effect in the SCI human population are limited.
METHODOLOGY: This study is a double-blind, parallel, two-group, randomized controlled trial with an interventional study design that aims to evaluate the effectiveness of aerobic exercise program on neuropathic pain and quality of life (QoL) in individuals with chronic paraplegia. Thirty individuals with chronic paraplegia with the neurological level of injury from T2 to L2 will be recruited from the rehabilitation department at a super specialty hospital based on the inclusion criteria. Using a 1:1 allocation ratio, the participants will be randomly assigned to one of the two groups. The intervention group will perform high-intensity interval training (HIIT) aerobic exercise using an arm ergometer based on their peak heart rate, and the control group will perform free-hand arm aerobic exercise. In both groups, the intervention will be delivered as 30-min sessions, four times a week for 6 weeks.
OUTCOME MEASURES: International Spinal Cord Injury Pain Basic Data Set Version 3.0 will be used for diagnosing and assessing neuropathic pain and its interference with day-to-day activities, mood, and sleep. The International Spinal Cord Society (ISCoS) QoL basic data set will be used to assess QoL, and 6-min push test distance will be used to assess peak heart rate and aerobic capacity.
DISCUSSION: The effectiveness of the aerobic exercise program will be assessed based on the changes in neuropathic pain score and its interference with day-to-day activities, mood, sleep, QoL, and aerobic capacity after 3 weeks mid-intervention and after 6 weeks post-intervention. The trial will provide new knowledge about the effectiveness of the aerobic exercise program in improving neuropathic pain and QoL in individuals with chronic paraplegia.
TRIAL REGISTRATION: Clinical Trials Registry-India CTRI/2023/08/056257. Registered on 8 August 2023.
Participants will receive newly formulated acetaminophen tablet orally in period 1 (Test) followed by 8 hour ER acetaminophen tablet orally in period 2 (Reference). Each period will be separated by a washout period of at least 7 days.
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new compounds of the general formula (I) R 1 -R 4  where X - oxygen or group CHR; C 1 -C 7  (identical or distinct) - hydrogen or R 1 -alkyl being R 5  together with R can forms a bond; R 5  - hydrogen or hydroxy-group, or R 7  together with R 6  forms a bond or a group -O-;   is a group R 10  where R 11  and   together with carbon atom with which they are bound form nitrogen-containing heterocycle, and their N-oxides and pharmaceutically acceptable salts. These compounds are power activators of potassium channels. On the base of synthesized compounds a pharmaceutical composition is prepared that shows relaxing effect on smooth muscles. Invention describes also a method of synthesis of compounds of the formula (I) that involves interaction of the corresponding ketone with organometallic compound followed by removing protective groups to obtain the corresponding intermediate compounds and this process is carried out in the presence of acid or acid chloroanhydride. EFFECT: improved method of synthesis. 13 cl, 2 tbl, 9 ex
After a screening period, 10 subjects with drug resistant epilepsy will first be assigned to not wear an inflatable helmet. Subjects will fill out questionnaires about their seizures and injuries. After approximately 3 months, patients will crossover to the "helmet" group.
This open-label, multicenter, randomized study will consist of a Phase Ib portion: a safety run-in period with 3 ascending doses of E7820; and a Phase II portion: a randomized 2-arm design. Approximately 95 patients with measurable, nonresectable locally advanced or metastatic colorectal adenocarcinoma, who have failed first-line chemotherapy, will be enrolled in the study (approximately 12 to 15 patients in the Phase Ib portion and 80 patients in the Phase II portion). Patients will only participate in either the Phase Ib or the Phase II portion of the study. Patients will receive up to a planned total of 12 cycles of study treatment unless there is occurrence of progressive disease, unacceptable toxicity, withdrawal of consent, withdrawal by the Investigator, lost to follow-up, or death, whichever occurs first. After 12 cycles, patients who demonstrate clinical benefit may continue single agent E7820 for long as clinical benefit is sustained and the treatment is well tolerated. If the treating physician does not feel comfortable discontinuing chemotherapy after 12 cycles, further chemotherapy may be considered following discussion with the medical monitor and sponsor.
The present invention discloses ointment mainly treating gynecopathy and concurrently treating gynopathy, weakness diseases, a cardiovascular disease and tumour for the technical field of traditional Chinese medicine. The present invention is composed of motherwort herb, salvia miltiorrhiza, angelica, hemlock parsley, safflower, pangolin, astragalus root, yam, nutgrass galingale rhizome, rehmannia root, white paeony root, madder root, common macrocarpium fruit, gastrodia elata, scorpion, barbed skullcap herb and spreading hedyotis herb. Because the present invention strictly selects medicine, the medicine is well combined to perform obvious efficiency. The present invention mainly treats the gynecology by the physiological characteristics of the heart, liver, spleen and kidney and has the aim for regulating yin and yang and eliminating pathogenic factors. The ointment has the effects of blood circulation activation, blood nourishing, vital energy supplementing, yin nourishing, kidney invigorating, spleen strengthening, moisture prevention, liver calming and pathogenic factor elimination. Compared with the prior art, the present invention has the advantages of good therapeutic effect and short treatment cycle.