anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The investigators plan a small trial of an existing drug in patients with COVID-19 at Salford Royal NHS Foundation Trust (SRFT) and Manchester Foundation Trust (MFT). The investigators will recruit patients with suspected or confirmed COVID-19 infection within 24 hours of being transfer in a Critical Care department. The investigators have been testing interleukin-1 receptor antagonist: IL-1Ra (known as Anakinra) for many years. Marketed as a treatment for rheumatoid arthritis and for some rare autoimmune diseases, we have shown Anakinra also reduces or blocks inflammation in a number of other conditions e.g. stroke and brain haemorrhage. The investigators have found it to be safe, easily administered and well tolerated. As part of the global response to the SARS-COV-2 pandemic, researchers have identified drugs that repurposing existing drugs. Anakinra has been proposed as a candidate therapy for COVID-19 and will be used in REMAP-CAP clinical trial as an intravenous (IV) therapy four times daily (qds). Whilst there is uncertainty about the therapeutic benefits, the investigators wish to explore the theory that they can achieve comparable concentrations in the blood using a subcutaneous (SC) injection twice daily (bd), as observed with IV therapy qds. We will randomise up to 40 patients to receive either SC Anakinra twice daily or IV Anakinra four-times daily for 14 days (or until discharge from CCU). They will measure changes in biomarkers in both groups and use the data to inform a mathematical model to simulate the effect the drug may have on the body. The aim is to the provide evidence that a lower dose SC Anakinra is as effective as higher dose IV.
In the study group, the intensive care oral care frequency assessment scale was applied to 55 patients at the end of the 16th hour, in addition to the assessment of pain and thirst at the 1st, 4th, 8th, and 16th hours postoperatively. In patients with a thirst of 3 and above, the bedside was lifted 30-450 times (to prevent bronchoaspiration), and cold water spray (kept in the refrigerator at +4°C and stored) was sprayed 3 times (approximately 2 ml) into the mouth of the patient every hour. Evidence suggests that the risk of bronchoaspiration is minimal up to the 50 mL and 1.5 mL/kg limit of gastric volume (Doi et al., 2021). For this, it is thought that the application of an average of 32 ml of cold water applied to the patients is reliable. The standard oral care of the clinic was applied to the patients who needed oral care. It was also recorded how many times oral care was given to the patients included in the study within 16 hours.
PURPOSE: A cosmetic composition containing Curcuma Wenyujin extract is provided to ensure antifungal activity and to prevent and relieve dermatomycosis. CONSTITUTION: A Curcuma Wenyujin oil has antifungal activity against skin fungi. The skin fungi are Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, or Microsporum canis. A cosmetic composition for preventing and suppressing dermatomycosis with antifungal activity contains 0.0001-30 weight% of Curcuma Wenyujin oil. The cosmetic composition is used in the form of foot cream, foot skin, or foot tissue. A foot cream for preventing and relieving dermatomycosis contains 0.05-3 weight% of Curcuma Wenyujin oil and 15-25 weight% of urea. A foot skin for preventing and suppressing dermatomycosis contains 0.05-3 weight% of Curcuma Wenyujin oil and 10-20 weight% of ethanol.
The application discloses an application of egg white protein hydrolysate in treating or preventing type 2 diabetes, belonging to the field of diabetes prevention and treatment. The food-borne bioactive peptide is one of the representatives of natural active compounds, and has an intervention effect on nutrition-related chronic diseases such as cardiovascular diseases, obesity, diabetes and the like. The improvement of glucose tolerance in insulin resistant rats by egg white derived peptides (EWP) has been demonstrated. However, their intervention in type 2 diabetes (T2 DM) and related mechanisms have yet to be elucidated. The application provides application of egg white protein hydrolysate in treating or preventing type 2 diabetes mellitus, and discloses that EWP intervention can obviously reduce fasting blood glucose of T2DM mice after 7 weeks, and the action mechanism of the EWP intervention can be related to inhibition of liver gluconeogenesis pathway. Liver non-targeted metabonomics analysis results show that EWP intervention can alter the liver metabolic profile of T2DM mice, with fatty acid hydroxy fatty acid esters (FAHFAs) potentially playing a key role in mediating EWP hypoglycemic effects.
The long-term goal of the proposed research is to improve clinical outcomes for Hoarding Disorder (HD), a common and potentially debilitating condition that poses a severe public health burden. The PI has developed and tested a cognitive-behavioral therapy (CBT) that appears moderately effective, although there is clear room for improvement. In the present study, the investigators propose to merge this line of research with the PI's recent NIH-supported neuroimaging research that points to specific functional abnormalities in regions of interest (ROIs) related to cognitive and affective decisionmaking processes. Patients with HD n = 80) will be randomized to CBT or wait list (WL). At pre-treatment, mid-treatment, and post-treatment, patients will undergo functional magnetic resonance imaging (fMRI) during an acquiring and discarding decision-making task that has been used successfully in the investigators' previous work. In addition, patients will complete a number of laboratory tasks designed to assess decision-making capacity and impairment. A group of healthy control (HC) participants (n = 40) will also complete these measures as a normative control group. The primary aim of the proposed study is to determine the extent to which the observed patterns of neural activity in HD change following CBT. Under this aim, the investigators predict that HD patients (vs.HCs) will show greater hemodynamic activity in ROIs associated with cognitive and affective aspects of decision-making. The investigators further predict that HD patients receiving CBT (vs. WL) will show decreased activity in those ROIs, and will no longer differ from HCs following CBT. A secondary aim of the proposed study is to determine the relationship between change in activity in brain regions of interest and hoarding-related symptoms and impairments. The investigators expect, that hemodynamic activity in the target ROIs will correlate with symptoms of HD and with performance on decision-making tasks; and that change in brain activity will correspond to both symptom and mechanism changes over the course of treatment. Finally, an exploratory aim is to explore, using both data-driven and model-constrained approaches, patterns of pre-treatment neural activity that predict response to CBT. The investigators predict that among treated HD patients, pre-treatment activity in the target ROIs will correlate significantly with HD symptom change from pre- to posttreatment. Results of the proposed study are expected to elucidate the neural mechanisms of successful response to CBT treatment for hoarding patients, and to set the stage for further treatment development and possible improvements in outcome for this disorder.
BACKGROUND: Haemorrhoidectomy is the gold standard for definitive treatment of high-grade symptomatic haemorrhoids but is often associated with substantial pain. This systematic review aims to explore the potential of flavonoids in alleviating the postoperative symptom burden following excisional haemorrhoidectomy.
METHODS: A systematic review of the literature was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PROSPERO CRD42023472711). Randomized controlled trials (RCTs) published PubMed, MEDLINE, Embase, and Scopus from inception to 1st December 2023 were retrieved. The primary outcome investigated was post-operative pain. Meta-analysis was performed using Review Manager version 5.4.1.
RESULTS: Ten articles with 775 patients were included. The meta-analysis identified statistically significant decreases in post-operative pain in favour of the flavonoid groups (Standardized Mean Difference -0.66 [95% confidence intervals (CI) -0.82, -0.52]; P < 0.00001), and bleeding (Odds Ratio 0.13 [95% CI 0.09, 0.19]; P < 0.00001).
CONCLUSION: Flavonoids show promise as a means of reducing pain associated with excisional haemorrhoidectomy. Further research is required to investigate topical routes of administration and standardize regimes.
Patients randomized to the occlusion treatment group will receive occlusion (patching) for 3 hours per day for at least 3 months. Choice of which eye to occlude, or whether to alternate daily, is at investigator's discretion.
BACKGROUND: Careful interpretation of the relation between phenotype changes of the heart and gene variants detected in dilated cardiomyopathy (DCM) is important for patient care and monitoring.
OBJECTIVE: We sought to assess the association between cardiac-related genes and whole-heart myocardial mechanics or morphometrics in nonischemic dilated cardiomyopathy (NIDCM).
METHODS: It was a prospective study consisting of patients with NIDCM. All patients were referred for genetic testing and a genetic analysis was performed using Illumina NextSeq 550 and a commercial gene capture panel of 233 genes (Systems Genomics, Cardiac-GeneSGKit®). It was analyzed whether there are significant differences in clinical, two-dimensional (2D) echocardiographic, and magnetic resonance imaging (MRI) parameters between patients with the genes variants and those without. 2D echocardiography and MRI were used to analyze myocardial mechanics and morphometrics.
RESULTS: The study group consisted of 95 patients with NIDCM and the average age was 49.7 ± 10.5. All echocardiographic and MRI parameters of myocardial mechanics (left ventricular ejection fraction 28.4 ± 8.7 and 30.7 ± 11.2, respectively) were reduced and all values of cardiac chambers were increased (left ventricular end-diastolic diameter 64.5 ± 5.9 mm and 69.5 ± 10.7 mm, respectively) in this group. It was noticed that most cases of whole-heart myocardial mechanics and morphometrics differences between patients with and without gene variants were in the genes GATAD1, LOX, RASA1, KRAS, and KRIT1. These genes have not been previously linked to DCM. It has emerged that KRAS and KRIT1 genes were associated with worse whole-heart mechanics and enlargement of all heart chambers. GATAD1, LOX, and RASA1 genes variants showed an association with better cardiac function and morphometrics parameters. It might be that these variants alone do not influence disease development enough to be selective in human evolution.
CONCLUSIONS: Combined variants in previously unreported genes related to DCM might play a significant role in affecting clinical, morphometrics, or myocardial mechanics parameters.
The study was performed using a ultrasound machine with linear probe settings at 50 mm depth and 40 decibel \[dB\] gain that did not change during the study. The probe was placed on vascular ultrasound measurement. The diameter of the brachial artery in the middle of the upper arm and the flow rate through the artery was measured on postoperative days 1 and 2. The presence of the edema was measured above the 3rd metacarpal bone as the distance from the skin surface to the periosteum. An average of three assessments was shown. Patient's age, body mass index (BMI), type of admission, white blood cells (WBC), C-reactive protein (CRP), and procalcitonin (PCT) were also registered.
A system and method for screening cervical cancer is disclosed. The system and method enable screening of cervical cancer locally at geographical location of subjects using minimum infrastructure. The system includes a visual inspection kit, a device, and a subject connection module. The visual inspection kit may include a vital stain having a predefined concentration, a sterile accessory, and an applicator accessory. The device may include an application for data collection, storage, transmission, retrieval and analytics and the subject connection module is configured to manage interaction with subjects. The method includes screening a subject using the visual inspection kit, storing and analyzing the images using the device, and connecting with subject using the subject connection module.
Patients diagnosed with coronary artery disease will undergo a 6 month cardiac rehabilitation program that is standard of care at the Toronto Rehabilitation Institute Rumsey Centre. The responses to cardiac rehabilitation for participants with coronary artery disease will be compared to participants with peripheral artery disease.
Tuina is a treatment method in traditional Chinese medicine which has analgesic effects and effectively alleviates the symptoms of neuropathic pain (NP). Transient receptor potential vanilloid type 1 (TRPV1) and transient receptor potential ankyrin type 1 (TRPA1) play major roles in transmitting nociceptive sensory signals in the nociceptive primary sensory dorsal root ganglion (DRG) nerve. The nitric oxide (NO)/cyclic guanosine 3',5'-monophosphate(cGMP) pathway exerts both nociceptive and antinociceptive effects in various chronic pain models. TRPV1 and TRPA1 mediate the influx of calcium, which stimulates the generation of NO. Subsequently, NO activates the NO/cGMP/protein kinase G (PKG) signaling pathway, thereby improving hyperalgesia. In the present study, oa rat model of NP with minor chronic constriction injury (CCI) of the right sciatic nerve of NP was established. The results of behavioral testing showed that, after a one-time tuina intervention, the mechanical withdrawal threshold (MWT) and thermal withdrawal latency (TWL) were prolonged to varying degrees in the tuina group compared with the model group. Similarly, the expression of TRPV1, TRPA1, NO, soluble guanylate cyclase β (sGCβ), cGMP, and PKG1 was significantly decreased in the DRG of the tuina and tuina + TRPV1/TRPA1 antagonist group was significantly decreased. These findings suggest that the tuina intervention can effectively improve the symptoms of thermal and mechanical allodynia caused by peripheral nerve injuries. Tuina exerts immediate analgesic effects through the TRPV1/TRPA1-NO-cGMP-PKG signaling pathway.
Patients with measurable radiation induced fibrosis of the neck. Patients will be randomized to applying Topical Sodermix Dismutase in the form of Sodermix(SOD) to the area of neck skin fibrosis twice a day for 12 weeks.
Introduction This research evaluates the effectiveness of video educations against patients fixed believes and knowledge that either not precise or overestimated, and compare with classic educational method such as Brochure. As many researches indicates the difficulties to initiate insulin therapy for type 2 diabetic patients due to overestimated barriers such as needle anxiety, feelings of guilt and failure, concerns about hypoglycemia, sense of loss of control over one's life and reduced quality of life. This research will introduce different educational tools to evaluate their effectiveness in breaking psychological insulin barriers.

Methodology It's a randomized controlled trial. Validated questionnaire (ITAS) was used to evaluate the psychological insulin barriers, video and Brochures were devolved as educational materials contain same contents and validated. Study conducted in King Abdulaziz city housing with total sample size of 126. They were divided into intervention group (video group) and controlled group (Brochure group). Both group filled the same questionnaire before the intervention. And then immediately after the intervention. Six weeks later, both groups filled the same questionnaire to measure the long-term effects.
The short wave diathermy group will consist of thirty one patients receiving a total of ten sessions of physical therapy over a two week period. Each week the patients will receive five session of physical therapy on consecutive days. The short wave diathermy group will be treated with a hotpack (20minutes), transcutaneous electrical nerve stimulation (TENS) at a frequency of 100Hz intensity adjusted to the patient's tolerability (twenty minutes) and short wave diathermy at a frequency of 27.12MHz (twenty minutes) applied to the lower back , abdominal and lower back muscle strengthening exercises.
A plant pox-removing face mask and a preparation method of the present invention belong to the cosmetic field. Dry bodies of twelve purely natural plants are selected as the raw materials, and the plants are a fritillary, a lightyellow a sophora root, a Japanese cayratia herb, an uniflower swisscentaury root, a Japanese thistle herb, a selfheal, a arrowhead, a heartleaf houttuynia herb, a Christina loosestrife, a caulis polygoni multiflori, a panax notoginseng and a snow lotuses. The raw materials are mixed uniformly according to the proportion and grinded to be 300 meshes by a hyperfine pulverizer and packed by an asepsis aluminum foil bag for sterilizing by a cobalt-60 gamma-ray irradiation, and the irradiation dosage is 6kgy, and the irradiation time is 24 hours, then the mealy finished product can be obtained. The pox-removing face mask has the detumescence function towards sedentariness acne, back carbuncle scrofulosis, carbuncle turgescence, pustule, carbuncle-abscess, furuncle toxin, whelk, comedo etc. when which are not mattery; when the sedentariness acne, the back carbuncle scrofulosis, the carbuncle turgescence, the pustule, the carbuncle-abscess, the furuncle toxin, the whelk, the comedo etc. become purulence, the pox-removing face mask can eliminate the purulence and generate muscle. The phenomena of facial pastiness and darkness can not occur, and especially the pox-removing face mask can renew the elasticity of the skin and smooth the uneven face.
The present invention provides engineered immune cells targeting BCMA and uses thereof. Specifically, the invention provides a BCMA-specific CAR comprising an antigen binding domain that is an S-derived scFv having an antibody heavy chain variable region as shown in SEQ ID NO. 9, and an antibody light chain variable region as shown in SEQ ID NO. 10. The invention also provides CAR-T cells comprising the CAR, as well as dual CAR and CAR T cells comprising an S-derived scFv and related uses thereof. Compared with CAR-T cells constructed by using other scFv, the CAR-T cells constructed by the invention have higher killing effect and tumor removing capability.
Frailty, a prevalent clinical syndrome in aging adults, is characterized by poor health outcomes, represented via a standardized frailty-phenotype (FP), and Frailty Index (FI). While the relevance of the syndrome is gaining awareness, much remains unclear about its underlying biology. Further elucidation of the genetic determinants and possible underlying mechanisms may help improve patients' outcomes allowing healthy aging.Genotype, clinical and demographic data of subjects (aged 60-73 years) from UK Biobank were utilized. FP was defined on Fried's criteria. FI was calculated using electronic-health-records. Genome-wide-association-studies (GWAS) were conducted and polygenic-risk-scores (PRS) were calculated for both FP and FI. Functional analysis provided interpretations of underlying biology. Finally, machine-learning (ML) models were trained using clinical, demographic and PRS towards identifying frail from non-frail individuals.Thirty-one loci were significantly associated with FI accounting for 12% heritability. Seventeen of those were known associations for body-mass-index, coronary diseases, cholesterol-levels, and longevity, while the rest were novel. Significant genes CDKN2B and APOE, previously implicated in aging, were reported to be enriched in lipoprotein-particle-remodeling. Linkage-disequilibrium-regression identified specific regulation in limbic-system, associated with long-term memory and cognitive-function. XGboost was established as the best performing ML model with area-under-curve as 85%, sensitivity and specificity as 0.75 and 0.8, respectively.This study provides novel insights into increased vulnerability and risk stratification of frailty syndrome via a multi-modal approach. The findings suggest frailty as a highly polygenic-trait, enriched in cholesterol-remodeling and metabolism and to be genetically associated with cognitive abilities. ML models utilizing FP and FI + PRS were established that identified frailty-syndrome patients with high accuracy.
PROBLEM TO BE SOLVED: To obtain the subject composition mixed with an anti-histamine agent having excellent administration feeling by formulating an antihistamic agent selected from ketotifen, epinastine and mequitazine with Echinacea. SOLUTION: This composition is obtained by formulating (A) one or more anti-histamine agent selected from the group consisting of ketotifen, epinastine and mequitazine with Echinacea (e.g. Echinacea purpurea, Echinacea angustifolia, Echinacea pallida, Echinacea paradoxa, Echinacea tennesseensis, Echinacea sanguinea, Echinacea simulata, Echinacea atrorubens). The amount of the component B mixed is 10-2,000 pts.wt. based on 1 pt.wt. of the component A in the case of using ketotifen fumarate, 1.3-200 pts.wt. in the case of using epinastine hydrochloride and 5-100 pts.wt. in the case of using mequitazine as the component A.
PROBLEM TO BE SOLVED: To provide a binder that forms a complex with a medicinal substance, and retains the medicinal substance in the endosome but releases it in the cytoplasm and/or in the nucleus when a lipid double-lamellar multifunctional envelope-type nano device (D-MEND) including the complex is taken up in a eukaryotic cell, and also to provide the complex of the binder and a medicinal substance, D-MEND including the complex, and liposome preparation including the D-MEND.SOLUTION: Polyhistidine modified with a hydrophobic group can form a complex with nucleic acid etc. by interactive binding, and retains the nucleic acid etc. under acidic conditions and releases it under neutral conditions. Thus the modified polyhistidine is useful as a binder or the like. The complex between the modified polyhistidine and nucleic acid etc. and D-MEND including the complex are useful to transport nucleic acid etc. into the cell, and also liposome preparations including the D-MEND including the complex are useful as the next generation of medicine.
Each subject will be randomly assigned to receive 1000 mg/day of TRU NIAGEN (nicotinamide riboside) for an 8-week treatment period. Subjects will be instructed to take two capsules of TRU NIAGEN in the morning with breakfast and two capsules of TRU NIAGEN in the evening with dinner. At the end of each 8-week treatment period subjects will crossover to the next treatment group until all three treatment periods have been completed at 24 weeks.
The invention discloses a traditional Chinese medicine composition for treating diabetes, which is prepared from the following components in parts by weight: 10-40 parts of coptis, 10-50 parts of mulberry bark and 20-60 parts of radix rehmanniae. The invention has the advantages of unique compatibility and wide material sources, has favorable function of reducing the blood sugar, and can be used for treating diabetes; and meanwhile, the invention can increase the weight of the diabetic and lower the mortality. The invention can lower the content of U-Albumin in the urine, and therefore, can be used for treating diabetic nephropathy, thereby having wide application prospects. The traditional Chinese medicine composition or extract thereof can be prepared into various preparations applicable to clinical treatment requirements, for example powder, granules, ointment or decoction. The invention also discloses a preparation method of the preparation. The preparation method is simple to operate and has the advantage of low production cost.