anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a traditional Chinese medicine preparation for treating eczema in pigs and a preparation method thereof. The traditional Chinese medicine preparation comprises: by weight, 1000 to 2000 parts of xanthium sibiricum patrin and 400 to 500 parts of goldhair hedyotis herb. The preparation method of the traditional Chinese medicine preparation comprises the following steps of mixing xanthium sibiricum patrin and goldhair hedyotis herb in proportion, putting the mixture into a container to decoct them by water, removing dregs and collecting juice after 20 minutes after decoction, wherein the mixture with a unit dose is decocted twice, and merging drug soup. A use method of the traditional Chinese medicine preparation comprises of scrubbing an affected part 2 to 3 times per day by the warm traditional Chinese medicine preparation or applying a gunny or old clothes immersed with the warm traditional Chinese medicine preparation to an affected part for 0.5 hours or spraying the traditional Chinese medicine preparation on an affected part by a sprayer 2 times per day. The compatibility of the traditional Chinese medicines prepared into the traditional Chinese medicine preparation is simple. The traditional Chinese medicines adopted by a formula of the traditional Chinese medicine preparation are natural, wherein xanthium sibiricum patrin is a stem leaf of a feverfew xanthium sibiricum and has the effects of dispelling wind, eliminating heat, relieving internal heat and killing parasites, and goldhair hedyotis herb is a whole goldhair hedyotis herb with a root and has the effect of clearing heat and removing moisture wherein goldhair hedyotis herb belongs to rubiaceae plants. The preparation method of the traditional Chinese medicine preparation has the advantages of simple processes, low cost, characteristics of simultaneous treatment of principal and subordinate symptoms, and substantial curative effects.
Patients will lie flat on their back on the examination couch with the arm in neutral position and the head turned slightly to the opposite side. Ultrasound scan will be performed sequentially starting from the base of the neck (supraclavicular fossa) to the upper part of the interscalene groove and then in the reverse direction to the supraclavicular fossa. After identifying the three trunks of the brachial plexus, ultrasound guided selective trunk block will be done using local anesthetic agents (a mixture of 2% lidocaine with 1:200,000 epinephrine and 0.5% levobupivacaine in a total of 20ml) will be injected at the superior, middle, and inferior trunks of the brachial plexus in order to anesthetize the whole upper limb.
The invention provides a high-content toltrazuril soluble powder, as well as a preparation method and application of the high-content toltrazuril soluble powder, relates to the field of the soluble powders, preparation methods and application of the soluble powders, and aims at solving the problems of the existing preparation method that the toltrazuril preparation is low in water solubility, low in bioavailability, poor in stability, and easy to generate precipitate and discolor so that the treatment effects and application of the toltrazuril preparation are greatly limited. The high-content toltrazuril soluble powder is prepared from toltrazuril, an alkaline pH (Potential of Hydrogen) regulator, a cosolvent and a soluble filler in parts by weight. The preparation method comprises the following steps of: 1, weighing; 2, mixing and preparing solution; and 3 preparing the powder by the spray drying process. The application is the application of the high-content toltrazuril soluble powder serving as the raw material in tablet preparations, granular preparations and freeze-dried powder preparations. The preparation method is simple in preparation process; the prepared powder contains the toltrazuril up to 60% and is quick to dissolve; and the preparations can be placed for three years at the room temperature without packing and discoloring. The high-content toltrazuril soluble powder is applicable to the field of veterinary drug preparations.
There is only one arm in the study. All patients (i.e. our 4 target populations) will undergo the same phenotyping procedure.
Surveillance of antimicrobial resistance (AMR) is a crucial strategy to combat AMR. Using routine surveillance data, we could detect and control hospital outbreaks of AMR bacteria as early as possible. Previously, we developed a framework for automatic detection of clusters of AMR bacteria using SaTScan, a free cluster detection tool integrated into WHONET. WHONET is a free software used globally for microbiological surveillance data management. We applied this framework to data from the Japan Nosocomial Infections Surveillance (JANIS), one of the world's most comprehensive and largest national AMR surveillance systems. Although WHONET-SaTScan has several cluster detection algorithms, no published studies have compared how different algorithms can produce varying results in cluster detection. Here, we conducted a comparison to detect clusters of vancomycin-resistant enterococci (VRE), which has been rare in Japan, by analyzing combinations of resistance to several key antimicrobials ("resistance profiles") using the comprehensive national routine AMR surveillance data of JANIS and validated the detection capabilities of each algorithm using publicly available reports of VRE clusters. All publicly reported VRE hospital outbreaks were detected as statistical clusters using the space-time uniform algorithm implemented in WHONET-SaTScan. In contrast, only 18.8% of the publicly reported outbreaks were detected using another algorithm (space-time permutation). The space-time uniform algorithm was also effective in identifying hospital wards affected by outbreaks attributed to specific resistance profiles. Although half of the publicly reported outbreaks were attributed to VRE resistant to five particular antimicrobials, four other resistance profiles also contributed to the outbreaks, highlighting the diversity of AMR bacteria within these occurrences. Our comparison revealed a clear advantage in using an algorithm (space-time uniform) for detecting VRE clusters in WHONET-SaTScan based on national surveillance data and further demonstrated the capability to distinguish detected clusters based on resistance profiles.
Mid-life and older African Americans (AAs), a population that is increasing in number, have high rates of cardiovascular-related morbidity and mortality in relation to Whites. For this population, dietary and physical activity behaviors are related to the incidence of cardiovascular disease (CVD). Few tested health promotion interventions tailored for mid-life and older AAs are available yet churches have been shown to be an effective environment for AA health programs. Thus, the overall goal of this project is to reduce CVD risk factors in mid-life and older AAs through implementing and evaluating a church-based health intervention. Using the Transtheoretical Model of Behavior Change (TTM) and Socio-ecological theory (SE), the objectives of this project were to: 1) determine the effectiveness of a church-based intervention in relation to dietary behaviors (food choice, dietary quality), habitual physical activity) and CVD clinical risk factors of mid-life and older African Americans by increasing consumption of fruits, vegetables and calcium-rich foods; decreasing consumption of fat, sugar and sodium; increasing habitual physical activity; and improving selected clinical outcomes (blood pressure, body weight, glucose, among others); 2) identify the differential influence of program components of the intervention; 3) examine variables that might mediate the process of goal achievement; and 4) determine variables that are related to stage of change progression in goal achievement. Midlife and older AAs (n=221) from six churches, three treatment and three comparison, in North Florida were randomly selected from the churches, stratifying by age and gender. The intervention, Health for Hearts United, was developed using a community-based participatory approach and included literature-based conceptual elements of awareness building, clinical learning and efficacy development. Instruments included a food and lifestyle habits questionnaire (food frequency, NCI fruit and vegetable screener, NCI fat screener, physical activity items, TTM items, background characteristics, among others). Clinical data, including 24 hour recall, were collected from a subsample of participants (n=104). Data were collected at four points: Baseline, 6 ,18 and 24 month. The project was guided by research and community advisory committees.
INTRODUCTION: Total hip arthroplasty is one of the most frequent surgical interventions in the hospital setting. Nonetheless, the ideal method to manage post-operative pain is still unknown. Multimodal analgesia techniques based on regional anaesthesia are amongst the most promising solutions.
OBJECTIVES: The aim of this study was to evaluate postoperative pain after total hip arthroplasty according to whether peripheral nerve block was performed (femoral block, fascia iliaca block and pericapsular nerve group block). Intravenous morphine consumption during the patient's stay in the post-anaesthesia care unit was measured, as well as the number of opioid rescues at 24 and 48 h post intervention. As secondary objectives, the prevalence of nerve injury, prolonged quadricipital block, and morphine consumption were established according to other variables of interest.
MATERIALS AND METHODS: In this observational retrospective study, data was collected from the electronic medical record of 656 traumatological surgery patients from April 2018 to August 2020, with the following inclusion criteria: over 18 years old, ASA I-III, primary total hip arthroplasty under general anaesthesia or subarachnoid anaesthesia (only with hyperbaric bupivacaine) and use of levobupivacaine for peripheral nerve block.
RESULTS: A total of 362 patients were selected. The main surgical indication was coxarthrosis (61.3%), followed by hip fracture (22.6%). Peripheral nerve blocks were performed on 169 patients (66.3% femoral, 27.7% PENG, and 6.0% fascia iliaca). Mean postoperative opioid consumption in PACU was lower in patients in who received a PENG (2.2 mg) or a femoral (3.27 mg) block, compared to those who received neither (6.69 mg). There were no differences in opioid rescues at 24 and 48 h after the procedure. Nerve injury incidence was low (.8%), and not associated with nerve blocks. The incidence of prolonged quadricipital paralysis was also low (1.3%), and was mainly associated with femoral nerve block (75% of cases).
CONCLUSIONS: This retrospective study supports the use of regional blocks as opioid-sparing techniques, highlighting their role in rapid functional recovery with no motor impairment.
SUSVIMO ocular implant insertion is a surgical procedure that is performed in an operating room. The procedure must be performed under aseptic conditions by a physician experienced in vitreoretinal surgery [see Dosage and Administration (2.1)].

The ocular implant is filled with SUSVIMO (ranibizumab injection) immediately prior to insertion. No more than 30 minutes should pass between the initial fill of the ocular implant and the insertion into the patient's eye.

After placing an infusion line in the eye, create at least a 6×6 mm peritomy of the conjunctiva and Tenon's capsule centered around the selected SUSVIMO implant location in the supero-temporal quadrant. Perform careful conjunctival incision, hemostasis of the underlying sclera, and generous undermining of Tenon's capsule. Using aseptic technique, fill the ocular implant [see Dosage and Administration (2.4)]. Using an MVR blade, create a full thickness dissection of the sclera 4 mm from the limbus until the pars plana is fully visible, with final target scleral incision length of 3.5 mm. Using a 532 nm laser endoprobe, apply contiguous, overlapping laser spots starting at 300 mW 1000 ms along the full length of the exposed pars plana and repeat until complete ablation is achieved. Pass a 3.2 mm slit knife perpendicularly through the center of the scleral dissection to open the underlying pars plana. Use the insertion tool to slowly insert the SUSVIMO implant into the sclero-pars plana incision perpendicular to the globe, ensuring that the long axis of the implant flange is properly aligned with the sclero-pars plana incision. Using the closed gripper tips of the insertion tool, seat the implant flush against the sclera. Clean any residual vitreous around the implant flange using a vitrector. Suture both Tenon's capsule and conjunctiva, using scleral anchoring at the apex of the peritomy, ensuring complete coverage of the implant flange. Refer to the complete SUSVIMO Instructions for Use for the initial fill and implant procedure included in the insertion tool assembly carton for further details.
Recently a great interest in the role of the endothelium in the pathophysiology of sepsis has been introduced. The endothelium is coated by a "thick" endothelial glycocalyx protecting it from becoming activated and prevents capillary leakage. The glycocalyx binds approximately 1-1.5 litres of the plasma portion of the circulating blood and regulates the dynamic exchange between the intra -and extravascular space, therefore, functioning both as a barrier and as a mechano transducer. Damage to the glycocalyx is caused by major trauma, major surgery, or ischemia and reperfusion injury, and resulting in vascular leakage. Damage to the endothelium is further augmented by resuscitation of crystalloids and colloids as well as related to bleeding. Thawed fresh frozen plasma may cause a further "inflammatory hit" towards the glycocalyx and endothelium. The degradation of the glycocalyx increases endothelial permeability with edema formation entitled 'the endothelial leakage syndrome', and resulting in the development of hypotension, pulmonary complications, abdominal compartment syndrome, multi-organ failure and death.

The current strategy for maintaining the intravascular volume in patients with acute critical illness focuses on the administration of crystalloids, such as Ringer-Acetate, and natural colloids. Crystalloids, especially, are known to extravasate and cause edema, which is associated with hypoperfusion and compromised vital organ function by the increased tissue pressure that limits oxygen delivery, and ultimately leading to the complications described above. Until recently, synthetic colloids were the preferred choice of fluids for these patients, but a Scandinavian study in patients with severe sepsis and septic shock (6S trial) demonstrated an increased mortality in patients receiving synthetic colloids, thereby, establishing the adverse effect of such a strategy. Consequently, new resuscitation fluids are needed, preferably not only to support the intravascular volume, but also to support and restore the endothelial integrity.
Hepatic adverse drug reactions (e.g., elevations in alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, total bilirubin) have been reported in clinical trials. The elevations in liver-related laboratory tests were generally reversible and did not require discontinuation of CRESEMBA. Cases of more severe hepatic adverse drug reactions including hepatitis, cholestasis or hepatic failure including death have been reported in patients with serious underlying medical conditions (e.g., hematologic malignancy) during treatment with azole antifungal agents, including CRESEMBA.

Evaluate liver-related laboratory tests at the start and during the course of CRESEMBA therapy. Monitor patients who develop abnormal liver-related laboratory tests during CRESEMBA therapy for the development of more severe hepatic injury. Discontinue CRESEMBA if clinical signs and symptoms consistent with liver disease develop that may be attributable to CRESEMBA [see Adverse Reactions (6.1)].
FIELD: cosmetics. SUBSTANCE: composition contains in the form of mixture: pseudo-latex formed by particles of film-forming polymer with acidic carboxylic functions having average diameter 10-300 nm. Acidic carboxylic functions of polymer are neutralized up to neutralization degree 10-80% with the help of monobasic nonvolatile agent which used as only one. Pseudo-latex contains in the amount of 0.8-20 wt.%, and preferably 1-10 wt.%, of dry substance at the rate of total weight of composition, and at least one wax with melting temperature of 60-110 C, and preferably 65-100 C, in the amount of 2-40 wt.% at the rate of total weight of composition. EFFECT: better length of eyelashes and their more beautiful bending. 11 cl, 8 ex
The invention discloses a varicella vaccine freeze-drying protective agent containing a sorbitol component. The protective agent includes sorbitol, human serum albumin, sucrose, dextran, trehalose, arginine, sodium glutamate and urea, and does not contain gelatin. The invention also discloses a preparation method and use of the protective agent. The varicella vaccine freeze-drying protective agent provided by the invention has simple composition and reasonable proportion, contains sorbitol and recombinant human serum albumin, and is free of gelatin. Animal derived ingredients are removed, the vaccine endotoxin content is significantly reduced, irritation and hazardness of the vaccine to the human body are greatly reduced, and the safety and stability of the vaccine are improved. And the preparation method has the characteristics of simple process, easy realization and high production efficiency, and can quickly prepare the varicella vaccine freeze-drying protective agent. The varicella vaccine freeze-drying protective agent provided by the invention can effectively improve the stability and safety of freeze-dried varicella vaccines, but not limited to varicella vaccines, and has a wide scope of application.
BACKGROUND: Tranexamic acid (TXA) is commonly used to reduce perioperative bleeding in various surgeries, including acetabular and pelvic fractures treated with open reduction and internal fixation (ORIF). However, research on TXA's effectiveness and safety in this context is conflicting. To address this, we conducted a systematic review and meta-analysis on TXA's efficacy and safety in patients with acetabular and pelvic fractures undergoing ORIF.
METHODS: We systematically searched Cochrane, PubMed, and EMBASE databases until August 30, 2023. Our evaluation of TXA focused on 6 domains: estimated blood loss (EBL), blood transfusion units, transfusion rates, thromboembolic events, other complications, and surgery duration. Data from these studies were analyzed using RevMan Manager 5.4.
RESULTS: This study included 4 randomized controlled trials with 179 patients with acetabular and pelvic fractures treated with TXA. The analysis showed that TXA did not significantly reduce EBL, packed red blood cell transfusion units, blood transfusion rates, or surgery duration. There was no significant difference in thromboembolic events or other postoperative complications, like surgical wound issues, pneumonia, heterotopic ossification, and sciatic nerve injuries, between the TXA and control groups.
CONCLUSION: TXA did not demonstrate a significant benefit in reducing perioperative bleeding or complications in patients treated with ORIF for acetabular and pelvic fractures. The utilization of TXA in such clinical scenarios remains a topic necessitating further rigorous investigation to delineate its role in this clinical setting.
PURPOSE: A 3',4',5,6,7-pentahydroxy flavanone compound and a method for preparing the same are provided to suppress MMP-1 generation and to enhance collagen synthesis. CONSTITUTION: A 3',4',5,6,7-pentahydroxy flavanone compound is denoted by chemical formula. A cosmetic composition for antiaging contains the compound as an active ingredient. A cosmetic composition for anti-wrinkling contains the compound as an active ingredient. A cosmetic composition for skin whitening contains the compound as an active ingredient. A cosmetic composition for anti-inflammation or anti-bacteria contains compound as an active ingredient. A method for preparing the compound comprises: a step of reacting 1,3,5,6-pentahydroxybenzene and caffeic acid to prepare compound 1; a step of performing cycloaddition of the compound 1 to prepare compound 2; and a step of reducing the compound 2 to prepare compound 3.
<P>PROBLEM TO BE SOLVED: To inform a user of usable information and to improve accuracy in diagnosis of a medical image by displaying a message that the result of detection is updated in a display means when the result of detection is updated.  <P>SOLUTION: In the medical information display device, a result of detection of an abnormal shadow candidate (a CAD result) detected from a medical image is added on the medical image to be displayed in a display part. The CAD result corresponding to the medical image is acquired, and whether the acquired CAD result is updated or not is determined. If the CAD result is updated, the message that the CAD result is updated is displayed in the display part. Specifically, if the CAD result arrives at a server device from a CAD device during or after the image reading, the message that the CAD result arrives is displayed in a viewer terminal.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Patients receive sotrovimab IV over 30 minutes within 1-7 days prior to the start of pre-transplant conditioning. Patients also undergo blood and nasal swab sample collection throughout the trial.
In this arm, participants will receive the 8-week internet-delivered cognitive behaviour therapy (ICBT) course for alcohol misuse with guidance from a health educator through regular weekly online messages. Participants may also be contacted through emails and phone calls. The team of guides consists of registered social workers, psychologists, and graduate students, with experience delivering ICBT.
Participants will complete six 45-minute sessions of reactive balance training. Participants will experience 40-60 perturbations during each session.
Participants in this condition at the time of the initial assessments (T1) will be told that the device they will be testing will improve their hearing. They will then be told that in-order to receive the maximum benefit from the hearing device, they should focus on instances in which they can hear better and worse. All participants will be instructed to put on the hearing device and listen to an audio twice per day for 6 days. After listening to the 2nd audio of the day, they will asked 1) if they perceive their hearing to be changed by the device; 2) to note any changes in what they heard in the audio focusing on the story in the ballad; and 3) whether their hearing is possibly impacted by activities and behavior and what they were doing.This condition will enable researchers to test the effects of the interaction between attention to variability and the placebo effect.
A system and method for providing computerized, knowledge-based medical diagnostic and treatment advice. The medical advice is provided to the general public over a telephone network. Two new authoring languages, interactive voice response and speech recognition are used to enable expert and general practitioner knowledge to be encoded for access by the public. "Meta" functions for time-density analysis of a number of factors regarding the number of medical complaints per unit of time are an integral part of the system. A semantic discrepancy evaluator routine along with a mental status examination are used to detect the consciousness level of a user of the system. A re-enter feature monitors the user's changing condition over time. A symptom severity analysis helps to respond to the changing conditions. System sensitivity factors may be changed at a global level or other levels to adjust the system advice as necessary.