anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Shaanxi Micot Technology Co. Ltd. is developing MT200605, a novel investigational synthetic small molecule tyrosine kinase B (TrkB) receptor agonist to mimic brain-derived neurotrophic factor (BDNF). It can directly bind to TrkB receptor to exert strong neuroprotective and nutritional effects and used for the indication of Treatment of brain tissue damage after cerebral ischemia-reperfusion and nerve repair after ischemic stroke.

The goal of this randomized, double-blind, placebo control, Phase I clinical trial is to evaluate the Safety, Tolerability, and Pharmacokinetics after Single Ascending Dose (SAD) and multiple Ascending Dose (MAD) of MT200605 for Injection in Healthy Subjects. The study was divided into two stages including 5 groups in SAD stage and 3 groups in MAD stage. 4 subjects were in the first corhort (C1) of SAD stage while the rest of the corhorts were 8 cases. The MT200605 and Placebo will be administrated by Intravenous injection.The dose level in SAD will be 0.15 (C1), 0.3(C2), 0.6(C3), 0.9(C4), and 1.2(C5) mg/kg. The dose level will be adjusted based on the safety and PK data of the completed SAD corhort. The dose level in MAD will be 0.3(C6), 0.6(C7), and 1.2(C8) mg/kg. The dose level will be adjusted based on the safety and PK data of the completed SAD and MAD corhort.
Participants received SAGE-217 10 mg capsules on Day 1, 20 mg on Day 2, 30 mg on Day 3, orally, with food in the evening. Beginning on Day 4 through Day 14, participants received a 40-mg total daily dose (administered as 10 mg with food in the morning and 30 mg with food in the evening).
This success greatly reduces the duration of surgery, and the side effects associated with local or general anesthesia. However, despite the sedation that can be administered before and during surgery (e.g. benzodiazepines and opioids), patients can experience significant anxiety along with a certain degree of pain and discomfort during surgery. Anxiety causes stress that causes the cardiovascular system to respond by activating the sympathetic nervous system, which causes an increase in heart rate and blood pressure (BP) levels. These mechanisms can complicate the surgical procedure due to increased intraocular pressure. Hypertension and tachycardia above 85 discharges per minute represent an increased risk of orbital bleeding during local anesthetic injection and potential perioperative supracoroidal expulsive bleeding. The sequence and pre-operative music intervention is to be an inexpensive, easy-to-implement technique that has no side effects, has no significant beneficial effects on the anxiety of patients in different surgical populations. Also, music intervention allows for better patient co-operation during surgery under topical anesthesia and a drop in intraoperative blood pressure. Another method that is effective in reducing anxiety and pain is the stress ball. The stress ball is usually a soft toy that is not greater than 7 cm, gets stuck, relieving stress and muscle tension, or manipulated with fingers for exercising the muscles. One of the methods of distracting attention, the stress ball is an effective way of ensuring cognitive focus. The stress ball method has been used to reduce patients' anxiety and pain. Stretching the stress ball during surgery increases the feeling of strength, allowing patients to have direct control over the object. In this way, surgical intervention has a positive effect on anxiety and patient satisfaction without intervention. While the literature includes studies involving the combination of stress ball use and music intervention on surgical patients, there is no research involving combined use of music and stress ball application in cataract surgery in a single study. The investigators work therefore contributes to literature.
The invention discloses a tumor typing and potential target prediction method based on an individual metabolic model, which comprises the following steps: the method comprises the following steps: constructing an individual metabolic network model of a tumor patient; step two: carrying out accurate molecular typing based on the metabolic characteristics of the individual metabolic network model of the tumor patient in the step one; step three: predicting genes having important influence on the growth of tumor cells as potential targets based on the individualized metabolic network model of the tumor patient in the step one. The invention has the following advantages: 1. the molecular typing scheme established by the invention has more obvious difference of corresponding survival curves. 2. The prognostic markers discovered based on the metabolic hierarchy can be detected through body fluid or blood, and are more convenient and easy to popularize. 3. The predicted potential target is obtained based on quantitative simulation of tumor cell growth, and patients with different types have personalized targets, so that the drug effectiveness response can be improved.
BACKGROUND: Maternal and child health is an important measure of national well-being. This study further explored the individual and combined effects of maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) on adverse birth weight-related outcomes.
METHODS: A retrospective study was carried out at a maternal and child health hospital from 2018 to 2021, and a total of 17,506 eligible women were invited to participate. The associations of pre-pregnancy BMI and GWG with adverse birth outcomes were examined by using restricted cubic spline regression and binary logistic regression.
RESULTS: Pre-pregnancy BMI and GWG had non-linear associations with low birth weight and macrosomia. They were associated with an increased risk of macrosomia (Pre-pregnancy BMI for OR = 1.170, 95%CI:1.144 to 1.197, P < 0.001, and GWG for OR = 1.071, 95%CI:1.054 to 1.089, P < 0.001) and large for gestational age infant (LGA) (Pre-pregnancy BMI for OR = 1.125, 95%CI:1.111 to 1.141, P < 0.001, and GWG for OR = 1.045, 95%CI:1.036 to 1.054, P < 0.001). The high risk of low birth weight and preterm birth was observed among the group of women with inadequate GWG. The risks of macrosomia and LGA increased with pre-pregnancy BMI from low weight to overweight and obesity, and GWG from inadequate to overabundance, while small for gestational age infant was more prevalent in the low pre-pregnancy BMI group.
CONCLUSIONS: Pre-pregnancy BMI and GWG exhibited non-linear associations with low birth weight and macrosomia. The various combinations of pre-pregnancy BMI and GWG had different effects on adverse birth weight-related outcomes.
Techniques are described for vaccine notification and scheduling in automated electronic delivery format. A system for immunization registry integration that supports vaccine notification and scheduling in automated electronic delivery format is provided. One method includes providing access to a scheduling application to schedule a patient appointment. The method may include receiving authorization to query an immunization registry based at least on the provided access. The method may also include determining one or more immunization opportunities based at least in part on the received authorization. Additionally, the method may communicating the one or more immunization opportunities based at least in part on the determining.
PURPOSE:To prevent diabetes and to prevent and treat geriatric diseases such as arteriosclerosis by making wheat containing apple fiber into noodles. CONSTITUTION:100 pts.wt. wheat flour is blended with 5-15 pts.wt. apple fiber and 33-37 pts.wt. solution of salt having 8-10 Baume degree concentration to give dough for noodles, which is extended to given thickness to give noodle belt. Then the noodle belt is cut to give long strip of noodles.
PURPOSE: Jejunal feeding (JF) indications in children have recently increased. However, surgical jejunostomy (SJ) is reported to be subjected to a high complication rate. The aim of the study is to focus on safety, effectiveness, and complications of SJ and to identify those categories of patients who could most benefit from it.
METHODS: A retrospective analysis of all SJ performed at Giannina Gaslini Children's Hospital between 2014 and 2022 was performed. Data were collected regarding demographics characteristics, past medical history, surgical indications, surgical technique (Roux-en-y (REYJ), omega jejunostomy (OJ)), complications and nutritional outcomes.
RESULTS: Fourteen patients were included. Nine (64%) had severe neurological impairment. The most frequent indication for SJ was gastroesophageal reflux. REYJ was performed in five (36%) patients, OJ in nine (64%); no technique appears to be superior. One patient experienced a major long-term complication. After a follow-up of 40 months (range: 1-152), five (36%) patients discontinued JF: three (21%) successfully completed JF cessation, and two (14%) had their jejunostomy closed due to JF intolerance.
CONCLUSIONS: Based on our experience and on data available in the literature, SJ should be recommended in selected patients as temporary procedure or as bridge treatment to prevent or at least delay more invasive surgeries.
Knee OA affects over 241 million people worldwide, and poses a significant burden to the healthcare system (Cross et al., 2014). Knee OA leads to decreased quadriceps muscle strength, and impaired postural control and joint proprioception (Hurley et al., 1997). These factors lead to balance impairments in individuals with osteoarthritis compared to controls (Wegener et al., 1997). It has been reported that the completion of a warm-up program improves the dynamic and static balance of healthy individuals (Daneshjoo et al., 2012). Therefore, exercise may acutely facilitate neuromuscular control, reduce stiffness and significantly improve dynamic balance in individuals with knee OA. Alternatively, muscular fatigue that may negate these benefits (Nardone et al., 1997). Given that falls are a devastating injury in the elderly (Sri-On et al, 2017), and that exercise programs improve balance (Carter et al, 2001; Tse et al, 2015) it is important to evaluate the acute effects of a single bout of exercise on balance performance in individuals with osteoarthritis. The Star Excursion Balance Test (SEBT) has been validated for quantifying dynamic balance in healthy individuals (Kinzey \& Armstrong, 1998) and individuals with knee OA (Kanko, 2017). It is important to evaluate the effects of exercise on balance in individuals with OA as changes in balance following exercise may lead to either impairments or improvements, and have direct implications for the safety of exercise as a recommended approach in OA.

This study will recruit 35 individuals with self-identified unilateral knee osteoarthritis, according to clinical criteria for classification of idiopathic knee OA (Altman et al., 1986). They will complete a Physical Activity Readiness Questionnaire for Everyone (PAR-Q+) to clear them for participation in physical activity (Warburton et al, 2011). They will complete a standard questionnaire assessing knee function: the Knee injury and Osteoarthritis Outcome Score (KOOS) (Roos et al, 2003). They will complete the star excursion balance test, on each of their affected and unaffected limbs, before and after completing a 30 minute bout of exercise. This exercise session will be supervised, and emphasizes optimal alignment of the trunk and lower limb joints relative to one another, as well as quality of movement performance, while dynamically and functionally strengthening the lower limb muscles (Bennell et al, 2011). The research participants will dictate the intensity and duration of the program.

Differences in performance between the two star excursion balance tests will reflect the changes due to exercise. The changes between their balance performance on each limb will reflect the changes due to osteoarthritis.
The invention relates to an application of Sarcaboside B in the preparation of medicines for resisting aseptic inflammation. The inflammation refers to the aseptic inflammation. The Sarcaboside B has a good anti-inflammatory effect. The application of the Sarcaboside B in the preparation of the medicines for resisting aseptic inflammation is disclosed by the invention for the first time. As the skeleton type of the Sarcaboside B belongs to a brand-new skeleton type, the Sarcaboside B has unexpected strong inhibitory activity on inflammation, and the possibility that other compounds provide revelation does not exist. The Sarcaboside B has prominently substantial characteristics and meanwhile has remarkably progressive significance when being used for resisting inflammation.
<P>PROBLEM TO BE SOLVED: To provide a new gel-shaped composition gelatinized at a low temperature, exhibiting heat-reversible gel/sol states, and enabling the impartment of good meltability in the mouth to a food, the impartment of good sense of use to a cosmetic and the control of release of medicament (e.g. application to suppository) or the like because of the reduction of the viscosity by body heat; and to provide the new gel-shaped composition capable of imparting properties and improving texture or feeling of swallowing in a food such as a gel-shaped food exemplified by jerry, a meat product exemplified by ham and sausage, a frozen dessert exemplified by ice cream, noodles and a deglutition-assisting food because of having acid resistance, elasticity and resistance to freezing and thawing, and capable of imparting thick feeling to a drink.  <P>SOLUTION: The gel-shaped composition contains a galactoxyloglucan and a xanthan gum. The gel-shaped composition is gelatinized at ≤35°C. The ratio of the formulated xanthan gum to the galactoxyloglucan is (1:100)-(100:1) by weight in the gel-shaped composition.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Pharmaceutical compositions for polyvalently presenting an agent for therapy are described. The pharmaceutical compositions contain a polyvalent presenter. In one embodiment, the polyvalent presenter has a formula as follows: (Y)-(X- A)n, wherein Y is a framework, X is a direct bond or a linker, A is a presented functional group, and n is greater than ten and is an integer selected such that the presented groups can interact with a plurality of target binding sites. The composition also can include a pharmaceutically acceptable carrier. Alternatively, the presenter itself can serve as its own pharmaceutically acceptable carrier. Methods for treating diseases or conditions also are described. The methods involve administering to a subject a plurality of groups A such that the treatment occurs. The treatment occurs by the interaction of a polyvalent presenter with a plurality of target binding sites B. Other aspects of the invention include polyvalent presenters packaged with instructions for use in the aforementioned methods and methods for designing polyvalent presenters which are useful within the methods of this invention. The polyvalent presenters disclosed herein provide for specificity in binding, which has a number of advantages. Furthermore, the polyvalent presenters permit positive and negative interactions.
A system, method, and apparatus for transferring blood donation files are disclosed. An example system includes a collection device located at a blood donation site and a collection server located in a remote location. The example collection device is configured to store blood donation information from blood donors within a blood donation batch file located at a designated directory of a memory, and store metadata related to the blood donation information to the blood donation batch file. The example collection device also transmits the blood donation batch file to a registered user device. The example collection server is configured to determine the registered user device is available via a network connection. Responsive to determining the user device is connected, the collection server acquires the blood donation batch file from the user device and aggregates the blood donation batch file with blood donation batch files received from other registered user devices.
The infection hypothesis is a new causative explanation for Alzheimer's disease (AD). In recent decades, various species of bacterial pathogens have been distinguished in the autopsy of Alzheimer's patients; however, the mechanism of bacterial contribution to AD pathology is still unknown. To explore the hypothesis, Cutibacterium acnes (C. acnes) was selected, and effects of its intracerebroventricular (ICV) inoculation in rats was evaluated. The results revealed that C. acnes causes memory impairment, which might be a consequence of upregulated Amyloid β (Aβ) deposits in the hippocampus; Aβ aggregates are co-localized with C. acnes colonies. The key point of our hypothesis is that the activation of the innate immune system by C. acnes through the TLR2/NF-κB/NLRP3 signaling pathway, eventually leads to increased neuroinflammation, which might be resulted from microgliosis and astrogliosis. Neuroinflammation increases oxidative stress and cell apoptosis. Overall, the obtained results of this study support our hypothesis that brain exposure to C. acnes prompted neuroinflammation with similar AD-like pathology.
PURPOSE: Misophonia is characterized by a reduced tolerance for specific sound triggers. This aspect has been relatively underexplored in audiology, with limited research from the audiological angle. Our primary objective is to compare the auditory late latency response (ALLR) findings between individuals with misophonia and those without it.
METHODS: A study compared individuals with significant misophonia to a healthy control group. Thirty misophonia participants were categorized into mild and moderate-to-severe groups based on their Amsterdam Misophonia Scale scores. The latency and amplitude of auditory response peaks were analyzed across the groups using the ALLR. Statistical tests included Shapiro-Wilk for data normality, one-way ANOVA for group differences, and Bonferroni post hoc analysis for detailed variation sources.
RESULTS: The result showed a significant difference in latency of P1 and N1 peaks (p < 0.05) of ALLR between the groups in both ears. This suggests a deficit in auditory processing at the cortical level in individuals with misophonia.
CONCLUSION: Our study substantiates the potential utility of the ALLR as a valuable instrument for evaluating misophonia, particularly from the audiological standpoint.
The present invention relates to a technology for powder infection purified and prepared from effective ingredients of traditional Chinese medicines, particularly to a gentiamarin preparation powder infection purified from large-leaf gentian roots and an application thereof as a medicine for protecting livers, benefiting gallbladders and resisting inflammation. The present invention is prepared from the following technology: the large-leaf gentian roots are decocted by adding water; water decoction is adsorbed by a D101 macroporous resin column and eluted to obtain residue; the residue is dissolved in 95 % of alcohol, filtered and laid aside to separate out crystals; the crystals are filtered to obtain a pure gentiamarin product; the pure gentiamarin product and mannitol for injection are dissolved by water for injection, filtered, filled and freeze dried to obtain a finished product. The present invention has the advantages of low cost of purification technology, no lipophilic component and simple and convenient purification method and brings convenience to post-treatment. Gentiamarin is separated from raw materials, and yield of the gentiamarin is more than 3 %. The gentiamarin is made into freeze drying powder infection with intravenous drip. The present invention also has the advantages of high stability and convenient use.
BACKGROUND: Medication-related osteonecrosis of the Jaw (MRONJ) is a rare but severe side effect in patients treated with medications such as Bisphosphonates (BPs). Its pathophysiological mechanism needs to be more precise. Establishing preventive measures and treatment standards is necessary. This study aimed to develop a composite hydrogel scaffold constituted by methacrylated gelatin (GelMA), methacrylated heparin (HepMA) and PRF, and investigate its potential application value in the prevention of MRONJ.
METHODS: GelMA, HepMA, and PRF were prepared using specific ratios for hydrogel scaffolds. Through mechanical properties and biocompatibility analysis, the release rate of growth factors and the ability to promote bone differentiation in vitro were evaluated. To explore the healing-enhancing effects of hydrogels in vivo, the composite hydrogel scaffold was implanted to the MRONJ rat model. Micro-computed tomography (Micro-CT) and histological examination were conducted to evaluate the bone morphology and tissue regeneration.
RESULTS: The Hep/GelMA-PRF hydrogel improved the degradation rate and swelling rate. It was also used to control the release rate of growth factors effectively. In vitro, the Hep/GelMA-PRF hydrogel was biocompatible and capable of reversing the inhibitory effect of zoledronic acid (ZOL) on the osteogenic differentiation of MC3T3-E1s. In vivo, the micro-CT analysis and histological evaluation demonstrated that the Hep/GelMA-PRF group exhibited the best tissue reconstruction. Moreover, compared to the ZOL group, the expression of osteogenesis proteins, including osteocalcin (OCN), type collagen I (Col I), and bone morphogenetic protein-2 (BMP-2) in the Hep/GelMA-PRF group were all significantly upregulated (P < 0.05).
CONCLUSIONS: The Hep/GelMA-PRF hydrogel scaffold could effectively control the release rate of growth factors, induce osteogenic differentiation, reduce inflammation, and keep a stable microenvironment for tissue repair. It has potential application value in the prevention of MRONJ.
The utility model relates to a cosmetics, in particular to a facial washcloth having the function of cosmetology. The facial washcloth (1) is manufactured to be the concavo-convex shape of face, mandible and neck by heat pressing cotton cloth, true silk or mixed fabric of the cotton cloth and the true silk, and eye holes (2), nostrils (3) and a mouth hole (4) are arranged on the facial washcloth. When in use, the raw materials and the components of cosmetology can be optional, and the raw materials and the components can be cucumber, aloe, cactus, egg white, Chinese goosebeery and facial cleanser, etc.; firstly, the cucumber and the aloe, etc. can be squeezed juice, the facial washcloth is evenly wetted in the juice of the cucumber and the aloe, etc., and then the wetted facial washcloth is applied on the face and the neck, so as to achieve the purpose of beautify; when not in use, the facial washcloth is cleaned, sterilized and stored for the next time reutilization. By adopting the structure, the facial washcloth of the utility model is simple in structure, low in price and convenient is use, and meets the using requirements of different people and can be prepared by using the formula that is selected by the user.
PURPOSE: A method for manufacturing a phospholipid-based biosurfactant is provided to ensure high water solubility, biodegradation, and low irritation, and to use the biosurfactant for hair care, cosmetic products, and fabric softeners. CONSTITUTION: A method for manufacturing a phospholipid-based biosurfactant comprises; a step of reacting phosphate compounds of chemical formula 2 with oxirane compounds of chemical formula 3 to prepare bis(3-halo-2-hydroxypropyl)phosphate compounds of chemical formula 4; and a step of binding the compounds of chemical formula 4 with an amidepropylamine compound of chemical formula 5. The steps are performed at 40-150 deg. C, using water, alcohols, or glycols. The compound of chemical formula 5 is prepared by condensing fatty acid compounds of chemical formula 6 with diamine compounds of chemical formula 7. The biosurfactant is used for hair care, cosmetics, medicines, fabric softeners, and cleansing agents.