anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A recombinant targeting protein and its preparation method and application belong to the field of biotechnology. The recombinant targeting protein comprises modified CEA scFv T84.66 fragment and Apoptin protein fragment. The Apoptin is connected to downstream of a single-chain antibody gene CEA scdsFv fragment through a section of flexible peptide, the combined fragment is cloned into an expression vector, the expression vector is transformed into host cell, and expression is induced by IPTG to obtain the specific anti-tumor recombinant targeting protein. After fractional washing method for preliminary purification and glutathione renaturation of the recombinant targeting protein, human hepatocellular carcinoma cells are used to carry out affinity determination, cell binding activity determination and specific cell killing activity analysis on the prepared recombinant targeting protein. Results show that the recombinant targeting protein can be effectively combined with the above carcinoma cells and has an obvious carcinoma cell killing activity. It shows that the recombinant targeting protein can be used for preparing anti-tumor drugs. The recombinant targeting protein is greatly expressed, and expression quantity can reach up to 44.1 mg/L after condition optimization.
PURPOSE OF REVIEW: The gut microbiota plays a crucial role in the pathogenesis of neuroinflammation and Alzheimer's and Parkinson's diseases. One of the main modulators of the gut microbiota is the diet, which directly influences host homeostasis and biological processes. Some dietary patterns can affect neurodegenerative diseases' progression through gut microbiota composition, gut permeability, and the synthesis and secretion of microbial-derived neurotrophic factors and neurotransmitters. This comprehensive review critically assesses existing studies investigating the impact of dietary interventions on the modulation of the microbiota in relation to neurodegenerative diseases and neuroinflammation.
RECENT FINDINGS: There are limited studies on the effects of specific diets, such as the ketogenic diet, Mediterranean diet, vegetarian diet, and Western diet, on the progression of neuroinflammation and Alzheimer's and Parkinson's diseases through the gut-brain axis. The ketogenic diet displays promising potential in ameliorating the clinical trajectory of mild cognitive impairment and Alzheimer's disease. However, conflicting outcomes were observed among various studies, highlighting the need to consider diverse types of ketogenic diets and their respective effects on clinical outcomes and gut microbiota composition. Vegetarian and Mediterranean diets, known for their anti-inflammatory properties, can be effective against Parkinson's disease, which is related to inflammation in the gut environment. On the other hand, the westernization of dietary patterns was associated with reduced gut microbial diversity and metabolites, which ultimately contributed to the development of neuroinflammation and cognitive impairment. Various studies examining the impact of dietary interventions on the gut-brain axis with regard to neuroinflammation and Alzheimer's and Parkinson's diseases are thoroughly reviewed in this article. A strong mechanistic explanation is required to fully understand the complex interactions between various dietary patterns, gut microbiota, and microbial metabolites and the effects these interactions have on cognitive function and the progression of these diseases.
The present invention discloses compound preparation having the functions of resisting aging and controlling osteoporosis and cerebral damage caused after long-term super physiological dose application of glucocorticoid. The preparation is prepared from red sage root, longspur epimedium, astragalus root and atractylodes. In the compound preparation, the red sage root, the epimedium herb, the astragalus root and the atractylodes all have the function of resisting aging, are capable of improving the function of the central nervous system and reducing bone loss together and effectively prevent the adverse reaction generated during the long-term super physiological dose application of the glucocorticoid. The long-term super physiological dose application of glucocorticoid prednisone can cause dementia, insanity, even encephalatrophy aphrenia, osteoporosis, etc. A research indicates that the preparation is capable of improving the intelligence of prednisone rats, effectively controls hippocampal neuron damage caused by prednisone, reduces the content of enzyme relevant to aging and also has the good prevention function to osteoporosis. Therefore, the preparation can be used for improving the organism memory capability, preventing the occurrence of hypophrenia and delaying aging and especially, effectively prevent cerebral damage and osteoporosis after the long-term super physiological dose application of the glucocorticoid.
Aim 1. Develop digital PrEP awareness materials to engage Black cis women. Using Human Centered Design and guided by (capability, opportunity, motivation, behavior; Theoretical Domains Framework)COM-B+TDF as a behavior change theory, the investigators will conduct 5 focus groups across two clinical sites with Black cis women ages 16 to 40 from high HIV-prevalence areas of Chicago (n=120 participants). This iterative process, in collaboration with the HBH communications team and led by an experienced human centered design (HCD) researcher, will lead to the development of digital PrEP awareness materials that will be piloted online. Through qualitative analysis of the focus groups, the investigators will generate knowledge regarding how TDF can be used to understand HIV prevention in this population.

Aim 2. Assess acceptability and feasibility of the PrEP awareness materials in new FQHC \& family planning clinics in Ending the HIV Epidemic (EHE) jurisdictions. Guided by implementation science frameworks and tools, the investigators will develop a toolkit and survey to accompany pilot distribution. The toolkit will provide guidance on using and adapting the awareness materials, based in the behavior change knowledge developed in aim 1. The survey will assess the acceptability, appropriateness, and feasibility of using the awareness materials, to prepare for further assessment and dissemination. The awareness materials, toolkit, and survey will be distributed locally and outside of Illinois, through Federally Qualified Health Centers and Planned Parenthood networks, as well as the Third Coast Center for AIDS Research (CFAR) and Getting to Zero networks, with a target of 20 online surveys collected.
The present invention relates to a peony astragalus polyglucoside composition for treating liver diseases and a preparation method thereof. The peony astragalus polyglucoside composition is composed of raw medicinal materials of white peony alba and astragalus root, and a medicinal preparation with active components of peony astragalus polyglucoside effective fraction groups comprises granules, capsules, tablets, injections, etc. and is used for preventing and treating chronic hepatitis, hepatic fibrosis and early liver cirrhosis of people and animals. In the preparation method, a macroporous resin adsorptive separation technology is used for extracting medicine effective fraction groups. Obtained materials have the advantages of high active ingredient content, specific ingredient, controllable quality, exact drug effect and small toxic side effect. The peony astragalus polyglucoside composition is modern traditional Chinese medicine with high efficiency and low poison. The preparation process of the present invention has good reproducibility and is suitable for commercial process.
BACKGROUND: Thyroid disorders(TD) poses a significant health threat to Americans due to its high incidence rate. Obesity, a common factor linked to thyroid disorders, has garnered increasing attention. While Body mass index (BMI) is a widely used obesity index, it fails to account for the distribution of muscle and fat in the body. Recently, tMFR has emerged as a crucial obesity index in clinical research, warranting further investigation into its association with TD.
OBJECTIVE: Exploring the association between tMFR and thyroid disorders.
METHOD: A comprehensive survey and data analysis were conducted using the NHANES database to investigate the relationship between tMFR and the risk of TD. This study utilized multiple logistic regression, smooth curve fitting, and subgroup analysis across four periods from 2011 to 2018.
RESULT: A total of 11,912 subjects were included in the study, showing a prevalence of 7.14% for TD. The research indicated that tMFR had an inverse correlation with the risk of TD in a comprehensive model (OR = 0.90, 95% CI 0.82 to 1.00). When tMFR was divided into quartiles (Q1-Q4), individuals in the highest quartile had a 28% lower risk of TD than those in Q1 (OR = 0.72, 95% CI 0.57 to 0.91). Analysis using smoothed curve fitting demonstrated a nonlinear relationship between tMFR and TD risk, with the inflection point for tMFR saturation effect identified as 1.5. Subgroup analysis further confirmed the strong association between tMFR and TD risk. Receiver operating characteristic (ROC) curve analysis indicated that tMFR exhibited superior predictive ability for TD relative to BMI.
CONCLUSION: The study found a negative association between tMFR and the risk of TD; however, additional prospective studies are required to validate these findings.
Participants assigned to the control arm will participate in a substance use education intervention. This intervention will entail review of material in the NACADA substance use education manual for adolescents, and will be followed by a question and answer session. The manual contains summarized and simple information on the harms and myths related to alcohol, tobacco, cannabis, prescription medication and khat use, substances. This education intervention will be delivered over a single 20-30 minute session by a counselor stationed at Rafiki clinic.
Bacteremia caused by Lactobacillus is rare, data on its clinical significance are based only on case reports and a limited number of studies, often difficult to interpret. Lactobacillus species is a commensal colonizer of the mouth, gastrointestinal and genitourinary tract. Its significance as a pathogen is overlooked frequently. The diagnosis of these infections requires a mutual relationship between the physician and the microbiologist to rule out contamination risk. Most patients with Lactobacillus bacteremia are immunosuppressed or patients at increased risk of symptomatic bacteremia with comorbidities, treated with broad-spectrum antibiotics and have indwelling venous catheters. Risk factors related to Lactobacillus bacteremia include impaired host defenses and severe underlying diseases, as well as prior surgery and prolonged antibiotic therapy ineffective for lactobacilli. We describe an unusual case of a woman, on chronic hemodialysis treatment, with a sepsis due to Lactobacillus casei and review the literature.
The invention relates to healthcare wine, especially relates to a thrombolytic cordyceps sinensis healthcare wine for preventing and treating thrombus, and belongs to the technical field of traditional Chinese medicine. The wine is prepared by mixing the following raw materials in parts by weight: 400 to 600 parts of cordyceps sinensis, 280 to 350 parts of wolfberry, 180 to 220 parts of mulberry twig, 350 to 450 parts of frankincense, 300 to 430 parts of myrrh, and 380 to 450 parts of radix astragali. The wine has the functions of tonifying the lung, boosting the kidney, stopping bleeding, resolving phlegm, boosting essence, improving eyesight, dispelling wind, strengthening joints, activating blood, relieving pains, dissipating and eliminating blood stasis, eliminating swelling, tonifying qi, securing the exterior, promoting urination, expelling toxin and pus, and promoting wound healing and tissue generation. The efficacy of the wine can be applied on the affected part directly, the blood is quickly activated, the blood stasis is removed, the kidney is nourished, the qi is boosted, and qi and blood are harmonized. The thrombolytic effect is good, the effect is quick, and no side effect has been found. If people drink the wine regularly for a long time, the thrombus can be prevented, and the wine is beneficial for the human health.
The invention provides a nifuratel solid preparation and a preparation method thereof. A nifuratel solid dispersion is contained. The solid dispersion comprises a nifuratel crude drug and an auxiliary material A. The auxiliary material A is selected from one or more of lactose, polyethylene glycol and mannitol. A preparation method of the nifuratel solid dispersion includes the steps that the nifuratel crude drug and the auxiliary material A are taken and mixed in a ball-milling mode in proportion, wherein the ball-milling mixing time ranges from 10 min to 360 min every kg of the nifuratel crude drug. The nifuratel solid dispersion and a nifuratel tablet containing the nifuratel solid dispersion have the high dissolution rate and bioavailability.
Use of stem cell transplant (mostly for hematologic cancers) is expected to increase 5-fold by 2030, when the number of survivors will reach 500,000. This highly toxic treatment causes a range of acute physical and psychological symptoms, which then persist for years for up to 45% of patients. To address gaps in existing symptom-focused behavioral interventions that can be added to standard patient care, the investigators developed Expressive Helping (EH), a low-cost, low-burden intervention that targets a range of physical and psychological symptoms in a broad group of transplant recipients. EH is completed in 4 brief structured writing sessions during and immediately after transplant, with instructions focused on having participants write about their transplant experience. Based on promising preliminary data, the investigators propose to determine whether EH can be used during and immediately after transplant to reduce common acute physical and psychological symptoms and prevent development of persistent physical and psychological symptoms. Assessments of physical symptoms and psychological symptoms will occur at baseline (prior to randomization), "nadir" (Day 7 post-transplant), "engraftment" (Day 14 post-transplant), 1 week post-intervention, 3-months post-intervention (primary endpoint, early post-transplant), 6-months post-intervention, and 12-months post-intervention (primary endpoint, later post-transplant). The investigators will also assess a select set of potential mediators and moderators of intervention effects. Participants will be adult cancer patients scheduled for allogeneic or autologous stem cell transplant at the study sites. After screening and consent, eligible patients will be enrolled in a parallel-group, 1:1 randomized controlled trial. Randomization will be stratified by study site (JTCC, Lombardi Comprehensive Cancer Center, LCCC, or Robert H. Lurie Comprehensive Cancer Center, RHLCCC); sex (linked with patient outcomes), age (18-59, ≥ 60), and transplant type (autologous, allogeneic). Staff performing assessments will be blind to study assignment. Participants cannot be blinded, but hypotheses will not be revealed to them until trial completion. They will be asked not to reveal their assignment to staff.
PURPOSE:To obtain a dental Ag-In alloy contg. Pt, having fine luster, and causing no discoloration after application by melting Pt, Ag and Pd, granulating the melt in water, melting the resulting granular alloy together with In, Zn and Al, and granulating the melt in water. CONSTITUTION:Necessary amounts of Pt, Ag and Pb are put in a crucible so as to make the Pt content 0.01-3%, and they are melted by heating with an oxygen burner. The melt is charged into water and solidified in the form of granules. The resulting granular Pt-Ag-Pd alloy is dried, put in a crucible together with necessary amounts of In, Zn and Al, and melted in an electric furnace heated to about 700 deg.C. The melt is agitated to well mix the constituent metals, and the melt is charged into water and solidified in the form of granules. The granules are taken out of the water and dried. By this method an Ag-In alloy contg. Pt and suitable for a crown, an inlay, etc. is obtd. The alloy has high toughness, satisfactory workability and metallic luster tinged with the color of platinum, and it causes no discoloration.
Lifetime carcinogenicity studies were conducted in CD-1 mice and F-344 rats. A statistically significant increase in the incidence of adenocarcinomas of the uterus was observed in female rats that received cevimeline at a dosage of 100 mg/kg/day (approximately 8 times the maximum human exposure based on comparison of AUC data). No other significant differences in tumor incidence were observed in either mice or rats.

Cevimeline exhibited no evidence of mutagenicity or clastogenicity in a battery of assays that included an Ames test, an in vitro chromosomal aberration study in mammalian cells, a mouse lymphoma study in L5178Y cells, or a micronucleus assay conducted in vivo in ICR mice.

Cevimeline did not adversely affect the reproductive performance or fertility of male Sprague-Dawley rats when administered for 63 days prior to mating and throughout the period of mating at dosages up to 45 mg/kg/day (approximately 5 times the maximum recommended dose for a 60 kg human following normalization of the data on the basis of body surface area estimates). Females that were treated with cevimeline at dosages up to 45 mg/kg/day from 14 days prior to mating through day seven of gestation exhibited a statistically significantly smaller number of implantations than did control animals.
Your Enlightened Side, plus more (YESplus) is an four-day, 15-hour integrative life skills workshop with a strong emphasis on breathing techniques and social connectedness. In addition to specific contemplative techniques such as yoga, mindfulness meditation, and compassion meditation that help cultivate inner peace, YESplus incorporates discussions and other activities to facilitate social connectedness, leadership, and community service. During the workshop, participants have ample time to learn and practice the Sudarshan Kriya Yoga (SKY) technique, as well as to ask questions. SKY has four sequential, form- and rhythm-specific breathing components interspersed with normal breathing while sitting in a relaxed position with eyes closed, followed by Yoga Nidra. A certified instructor with a minimum of 1,000 hours of SKY instruction training will lead each workshop.
PURPOSE:To obtain powder for cosmetics capable of being homogeneously and stably blended with the cosmetics and having ultraviolet ray shielding effects by treating the surface of an oxide, having a specific particle diameter and dispersed in a plastic. CONSTITUTION:A plastic is dissolved in an adequate amount of an organic solvent (e.g. benzene), and dispersing an oxide, having 0.001-0.3mum particle diameter and selected from titanium oxide, zinc oxide and iron oxide therein while stirring the solution. The above-mentioned oxide may be subjected to surface treatment with a silicone and/or ionic surfactant or anion surfactant. Powder for cosmetics is then dispersed in the resultant solution and dried to afford the objective substance. The powder for the cosmetic has 0.1-200mum average particle diameter and is blended in an amount of 1-90%. The plastic is used in an amount of 0.1-40 pts.wt. based on 100 pts.wt. powder for the cosmetics and the oxide is used in an amount of <=30 pts.wt. based on 1 pt.wt. plastic.
Newborns are as the primary recipients of blood transfusions. There is a possibility of an association between blood transfusion and unfavorable outcomes. Such complications not only imperil the lives of newborns but also cause long hospitalization. Our objective is to explore the predictor variables that may lead to extended hospital stays in neonatal intensive care unit (NICU) patients who have undergone blood transfusions and develop a predictive nomogram. A retrospective review of 539 neonates who underwent blood transfusion was conducted using median and interquartile ranges to describe their length of stay (LOS). Neonates with LOS above the 75th percentile (P75) were categorized as having a long LOS. The Least Absolute Shrinkage and Selection Operator (LASSO) regression method was employed to screen variables and construct a risk model for long LOS. A multiple logistic regression prediction model was then constructed using the selected variables from the LASSO regression model. The significance of the prediction model was evaluated by calculating the area under the ROC curve (AUC) and assessing the confidence interval around the AUC. The calibration curve is used to further validate the model's calibration and predictability. The model's clinical effectiveness was assessed through decision curve analysis. To evaluate the generalizability of the model, fivefold cross-validation was employed. Internal validation of the models was performed using bootstrap validation. Among the 539 infants who received blood transfusions, 398 infants (P75) had a length of stay (LOS) within the normal range of 34 days, according to the interquartile range. However, 141 infants (P75) experienced long LOS beyond the normal range. The predictive model included six variables: gestational age (GA) (< 28 weeks), birth weight (BW) (< 1000 g), type of respiratory support, umbilical venous catheter (UVC), sepsis, and resuscitation frequency. The area under the receiver operating characteristic (ROC) curve (AUC) for the training set was 0.851 (95% CI 0.805-0.891), and for the validation set, it was 0.859 (95% CI 0.789-0.920). Fivefold cross-validation indicates that the model has good generalization ability. The calibration curve demonstrated a strong correlation between the predicted risk and the observed actual risk, indicating good consistency. When the intervention threshold was set at 2%, the decision curve analysis indicated that the model had greater clinical utility. The results of our study have led to the development of a novel nomogram that can assist clinicians in predicting the probability of long hospitalization in blood transfused infants with reasonable accuracy. Our findings indicate that GA (< 28 weeks), BW(< 1000 g), type of respiratory support, UVC, sepsis, and resuscitation frequency are associated with a higher likelihood of extended hospital stays among newborns who have received blood transfusions.
The invention discloses a herbal medicine for treatment of high fever caused by cold. Cold and high fever can be treated with traditional Chinese medicine, injections and transfusion, and can also be treated with artemisia apiacea and lotus seed core. The herbal medicine possesses better and rapid curative effect, and is cheaper. When an adult has a fever, taking 500g of fresh artemisia apiacea juice, and the adult will soon rally from the fever. Dosage is changed appropriately according to age and weight for children. In autumn and winter, lotus seed core, instead of artemisia apiacea which is not available, can be used for treatment of high fever Dosage and administration are that: 7 to 8 grains of the herbal medicine for children under three; 10 to 12 grains of the herbal medicine for children over three, and 24 to 30 grains of the herbal medicine for adults; and the herbal medicine is mixed to be slurry and taken with cooled water. Curative effect for high fever is excellent.
Subjects will also receive (cross-over) six weeks of educational classes. The Education program will teach subjects, chronic disease self-management - how to live better with their parkinsonism. Classes will consist of 6 subjects per group meeting for 90 minute sessions, once a week for six weeks. Subject will do an additional 120 minutes of relaxation at home/week.