anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: We conducted a prospective observational study to elucidate the long-term prognosis and management of chronic obstructive pulmonary disease (COPD) in clinical practice in Japan in the mid-2010s.
METHODS: This prospective cohort study included 29 facilities. Data from 427 patients clinically diagnosed with COPD, enrolled between September 2013 and April 2016, were analyzed. Interstitial pneumonia was excluded through a central multidisciplinary discussion. Follow-up data were collected for up to 5 years after patient registration.
RESULTS: At the time of registration, 53 patients clinically diagnosed with COPD did not have airflow limitation (AFL). In the cohort with AFL (n = 374), 232 patients completed a 5-year follow-up, while 49 patients died during the 1576.6 person-years of observation. The mean age was 71.7 years with an overall 5-year survival rate of 85.4%. Stratified by % forced expiratory volume in one second (FEV1), survival rates were 93.6% in the mild and moderate AFL group, 82.5% in the severe AFL group, and 66.1% in the very severe AFL group. The prognosis of the subpopulation without AFL was poor with a 5-year survival of 81.6%. This subpopulation exhibited respiratory symptoms, low vital capacity and total lung capacity, and emphysematous changes.
CONCLUSIONS: Our study presents the 5-year survival and real-world clinical practice scenario of a prospective cohort of patients clinically diagnosed with COPD in Japan in the mid-2010s. The survival rates of our cohort were numerically better than the Japanese cohort in the 1990s, regardless of the high median age of this cohort. Overall, 12.4% of the patients in this cohort with no AFL at registration exhibited respiratory symptoms and distinct spirometric patterns, and had a poor prognosis.
The present invention discloses medicine for treating bone injury. The medicine is prepared by 36 kinds of main medicine, such as crinis ustus, calotropis, zhechong, saffron, radix, paeoniae rubra, angelica, peach seed, frankincense, myrrh, etc. and 13 kinds of adjuvant medicine, such as prairie milk vetch, cape jasmine fruit, tree peony bark, amur corktree bark, etc. The medicine of the present invention is screened reasonably compatible Chinese herbal medicine which is based on the recognition and the therapeutic principle of Chinese medicine to bone injury, refers modern pharmacology research achievements, and has the functions of blood activation, clot absorption and absorption promotion. Ischemia and anoxic anoxia of local histiocyte can be improved, microcirculation is improved, and the present invention has an obvious function for curing bone injury, especially the healing of bone fracture. In more than five thousand cases treated by the medicine, the effective rate can reach 100%, and the cure rate can reach 98%.
The invention relates to a traditional Chinese medicinal preparation, in particular to a traditional Chinese medicinal preparation for treating advanced-stage pertussis. The traditional Chinese medicinal preparation is characterized by being prepared from the following traditional Chinese medicinal materials in parts by weight: 20-30 parts of herb of Indian abutilon, 15-20 parts of rhizoma polygonati, 10-15 parts of ventilago leiocarpa benth, 10-15 parts of asparagus cochinchinensis, 10-15 parts of human placenta, 15-20 parts of turtle shell, 15-20 parts of orchidaceae dendrobium faulhaberianum, 15-20 parts of Tofieldia divergens Bur. et Franch.[Tofieldia yunnanensis Franch.], 20-30 parts of root of kakuda figwort, 5-10 parts of ludisia discolor, 20-30 parts of herb of creeping rattlesnake plantain, 15-20 parts of the tuber of stemona, 10-15 parts of herb of nightshadeleaf ironweed, 10-15 parts of leaf of ford nervilia, and 5-10 parts of all-grass of creeping bulbophyllum. The traditional Chinese medicinal preparation has the advantages that the used traditional Chinese medicinal materials accord with the stipulation of the Chinese pharmacopoeia, and are safe and reliable, the traditional Chinese medicinal materials are mixed together to achieve the efficacies of tonifying qi and nourishing yin, as well as moistening lung to arrest cough, and the traditional Chinese medicinal preparation has the characteristics of being definite in curative effects, rapid in taking effect, high in cure rate, and free of side effects when used for treating advanced-stage pertussis.
Participants will receive 5\*5Gy standard short-course radiation (radiation targeting the tumor bed and surrounding tumor-draining lymph nodes) concurrently with CAPOX and tislelizumab regimens: Oxaliplatin, 130mg/m2, intravenous infusion,d1 of each cycle; Capecitabine, 1000mg/m2, PO, BID, d1-14 and tislelizumab, 200mg intravenous infusion d1 of each cycle. CAPOX and tislelizumab repeat every 3 weeks for 4 cycles. After treatment, digital rectal examination, pelvic MRI, endoscopy, and biopsy will be performed to evaluate the tumor regression grade. Patients will receive TME surgery after the chemo-immunotherapy, pCR rate and TRG grade will be evaluated.
FIELD: medicine. SUBSTANCE: method involves puncturing suppurative focus, discharging the contents and rinsing with antiseptic solution. Antibiotic dose mixed with Oxytocin in the amount of 5 MU per one officinal flask of antibiotic. Bacteriological examination of suppurative cavity contents is carried out to detect Staphylococcus aureus presence. Antilysozyme and anticarnosine activity is determined in the selected pathogen culture. The treatment is continued until staphylococcus is vanished or its antilysozyme and anticarnosine activity becomes equal to at least 20%. EFFECT: enhanced effectiveness of treatment. 2 tbl
This study aimed to clarify other diseases claimed simultaneously with acute upper respiratory infection (URI), antibiotic prescriptions, and examinations associated with infectious diseases in pediatric patients with acute URI insurance claims at otorhinolaryngology outpatient visits. Pediatric patients who visited an otolaryngology department between 2019 and 2021 and were definitively diagnosed with URI were selected using a large Japanese medical claims database. Patient backgrounds, antibiotic use, and examinations were descriptively evaluated. In total, 8010 patients were included in the analysis. The median number (interquartile range) of diseases claimed in the same month as acute URI was 4 (3-6). Only 519 (6.5 %) patients were claimed as acute URI alone. Regardless of the prescription of antibiotics, the most commonly redundantly claimed disease in these patients was allergic rhinitis, followed by acute bronchitis, acute sinusitis, and earwax impaction. The frequently prescribed antibiotics were third-generation cephalosporins, macrolides, and penicillins with extended-spectrum, including amoxicillin which was recommended by the Japanese manual; the proportion of patients with examinations was low (2.9-21.7 %). Among patients with acute URI, diagnoses requiring antibiotics were also claimed; therefore, when evaluating acute URI using the Japanese medical claims database, care must be taken in patient selection. Moreover, the implementation rate of examinations necessary for diagnosis was low, so there is an urgent need to develop an environment where examinations can be conducted in outpatient settings.
Participants in this arm will undergo an early oral glucose tolerance test (OGTT) before 16 weeks' gestation, however, the results will be concealed from the participants and study investigators, and results will not be acted upon (unless they are suggestive of pre-existing type 2 diabetes mellitus as reviewed by an independent clinician, in which case appropriate follow-up will be arranged). All participants (except those with results suggestive of type 2 diabetes) will undertake the routine OGTT at 24-28 weeks' gestation, as per standard care.
Beginning day 0 of course 1, participants undergo stereotactic body radiation therapy 5 days a week for 1 week and receive durvalumab IV over 1 hour on days 0 and 27 in the absence of disease progression or unacceptable toxicity. Participants then undergo transoral robotic surgery and modified radical neck dissection between weeks 6-8. Beginning week 12, participants then receive durvalumab IV over 1 hour every 4 weeks. Treatment repeats every 4 weeks for up to 4 courses in the absence of disease progression or unacceptable toxicity.
Patients should be counseled that antibacterial drugs including cefpodoxime proxetil tablets, should only be used to treat bacterial infections. They do not treat viral infections (e.g., the common cold). When cefpodoxime proxetil tablets, is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by cefpodoxime proxetil tablets, or other antibacterial drugs in the future.

  


Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.
PURPOSE:To obtain a cosmetic having high stability and causing little skin disorder by using a saturated higher fatty acid ester having methyl group on the side chain as a cosmetic base. CONSTITUTION:A compound of formula R1.COOR2 (R1 is 17C alkyl having methyl on side chain; R2 is >=20C saturated higher alkyl) is compounded as a cosmetic base. The 18C saturated higher fatty acid used as a part of the raw material for the above compound can be produced e.g. by hydrogenating the unsaturated fatty acid obtained as a by-product in the synthesis of a dimer acid from oleic acid. The alcohol is preferably a beta-side chain alcohol such as 2-octyldodecanol and 2-decyltetradecanol. The total or a part of the conventional oily base is substituted with the compound of the formula to obtain a base cosmetic such as cream, milky lotion and body lotion, a make-up cosmetic such as lipstick, foundation and eye shadow and a hair cosmetic such as shampoo, rinse and hair-conditioner.
Participants undergo TMLI BID on days -8 to -5, and receive fludarabine IV on days -4 to -2 and melphalan on day -2. Participants then undergo alloHCT on day 0.
FIELD: cosmetics. SUBSTANCE: invention relates to composition for oxidative staining keratin fibers including hair that comprises oxidizing base, 2-amino-4-N-(β-hydroxyethyl)amino- anisole as dye-forming component and enzyme of laccase type in medium suitable for staining. Invention relates also to method for staining where this composition is used and kit including components of the claimed composition. Invention provides intense, low-selective staining fibers and resistance against aggressive factors. EFFECT: valuable properties of composition. 26 cl
FIELD: medicine, veterinary science. SUBSTANCE: agent is based on hydrophobic derivatives of interferon inducing agents. New aspect of invention is the use of esters of 10-methylenecarboxy-9-acridone as low-molecular interferon inducing agent together with pharmaceutically acceptable carrier. Also, invention relates to agents providing water-solubility of inducing agent and microcapsulation at lipid carrier. Proposed agent is used in antiviral therapy. EFFECT: enhanced effectiveness of agent. 3 cl
Sham TMS will be administered by tilting the coil 90° off the scalp, with one wing of the coil touching the scalp. This sham-TMS approach produces a clicking sound that is very similar to an active TMS pulse and induces a voltage in the brain that is more than 75% lower than active TMS.
Nasopharyngeal carcinoma (NPC) is endemic in Southern China and Southeast Asia. Several prospective randomized trials have demonstrated that concurrent chemoradiotherapy was superior to radiotherapy alone in the treatment of locoregionally advanced NPC. Cisplatin-based chemotherapy has been shown to have higher response rates in NPC than noncisplatin regimens. However, the patients' compliance was unsatisfactory because the obvious gastrointestinal toxicity of cisplatin. Nedaplatin is the new second generation platinum and it has slight gastrointestinal reaction. Our trial is in order to study the effectiveness of nedaplatin or cisplatin with intensity-modulated radiation therapy (IMRT) chemoradiotherapy in treating patients with locoregionally advanced NPC.
This proposal is a phase I, open-label study of a 4-Dose Regimen of Escalating Doses of 177Lu-LNC1004 Injection in patients with recurrent or metastatic, fibroblast activation protein-positive solid tumors. The treatment regimen will consist of a single dose intravenous administration of 177Lu-LNC1004 Injection per 6-week cycle, for a total of 2 cycles. The dose per cycle will be fixed for each patient and will be escalated in 4 different dose levels, from 30 mCi to 100 mCi (1.11 - 3.7 GBq).

This classic 3+3 design includes 3 patients for the first dose level group. If no DLT occurs, 3 patients will be enrolled at the next dose level. If a DLT occurs at a certain dose level, 3 additional patients will be enrolled at the previous dose level. The highest dose with no more than 1 DLT out of 6 patients will be defined as MTD. If there is no MTD observed after the dose escalation up to 100 mCi, a comprehensive evaluation should be made by investigator and sponsor to determine whether an escalation to a higher dose can be conducted or not based on the known safety, radiation dose and efficacy characteristics.
The invention discloses a multienzyme Chinese and western medicine combined preparation for treating nephritis. The preparation is prepared from a Chinese herbal medicinal ingredient extracting solution, western medicine ingredients and multiple enzymes. The Chinese herbal medicinal ingredient extracting solution is prepared from hairyvein agrimony, potentilla multifida, dysosma difformis, leonurus, herbs of hydrocotyle sibthorpioides, persicaria perfoliata, satyrium roots, common bluebeard herbs, heterophyllous wing seedtreeroots, dryopteris atrata, spiranthes sinensis ames, periostracum cicada, orchis, pendulous euonymus, polytrchum commune, ophiopogon latifolius, chonemorpha megacalyx pierre, chelonopsis odontochila, common euscaphis fruit seeds, centipeda minima, christia constricta, astragalus membranaceus, sculellaria barbata, herbs of Chinese gymnotheca, nidus vespae, herba epimedii, human placenta, pseudo-ginseng and platycladi seeds which are matched by weight. The western medicine ingredients include penicillin, vitamin K, casein phosphopeptides and sorbitol. The multiple enzymes include bromelain, lumbrukinase, lactase and cysteine protease which are matched by weight. The combined preparation can clear away heat and toxic materials, induce diuresis to reduce edema, and warm kidney and excrete dampness, and drug resistance can not be generated.
CSF-venous fistulas (CVFs) are a common cause of spontaneous intracranial hypotension. Despite their relatively frequent occurrence, they can be exceedingly difficult to detect on imaging. Since the initial description of CVFs in 2014, the recognition and diagnosis of this type of CSF leak has continually increased. As a result of multi-institutional efforts, a wide spectrum of imaging modalities and specialized techniques for CVF detection is now available. It is important for radiologists to be familiar with the multitude of available techniques, because each has unique advantages and drawbacks. In this article, we review the spectrum of imaging modalities available for the detection of CVFs, explain the advantages and disadvantages of each, provide typical imaging examples, and discuss provocative maneuvers that may improve the conspicuity of CVFs. Discussed modalities include conventional CT myelography, dynamic myelography, digital subtraction myelography, conebeam CT myelography, decubitus CT myelography by using conventional energy-integrating detector scanners, decubitus photon counting CT myelography, and intrathecal gadolinium MR myelography. Additional topics to be discussed include optimal patient positioning, respiratory techniques, and intrathecal pressure augmentation.
BACKGROUND: Pulmonary vein isolation (PVI) is the cornerstone of catheter ablation of atrial fibrillation (AF); however, the results are suboptimal for persistent AF. The left atrial posterior wall (LAPW) is thought to be a major additional area in initiation and perpetuation of persistent AF. Therefore, adjunctive ablation of the posterior wall may reduce AF recurrence in patients with persistent AF.
OBJECTIVE: The objective of this study was to compare outcomes of catheter ablation in patients with persistent AF using PVI alone versus a combination of PVI and LAPW isolation.
METHODS: Literature search was conducted in PubMed, PubMed Central, Scopus, and Embase since inception to February 2023. Screening of studies was done via Covidence software. Risk of bias assessment was done using appropriate tools. Data extraction and a narrative synthesis were carried out accordingly.
RESULTS: Ten studies were included, of which five were randomized controlled trials. PVI with LAPW ablation group had significantly lower recurrence of overall atrial tachyarrhythmia (OR 0.47, CI 0.32-0.70) and AF (OR 0.39, CI 0.23-0.69). In sensitivity analysis, freedom from atrial arrhythmias was noted to be significantly higher in the PVI with LAPW ablation group (OR 2.22, CI 1.36-3.64). However, there was no significant difference in occurrence of atrial flutter (OR 1.36, CI 0.86-2.14) or with periprocedural adverse events (OR 1.10, CI 0.60-1.99).
CONCLUSION: LAPW ablation, in addition to PVI, significantly improves the rates of arrhythmia freedom and reduces the recurrence of overall atrial tachyarrhythmia. There was no significant difference in atrial flutter or periprocedural adverse events.
Combined laser therapy: An Er:YAG laser (160 mj/pulse, 10 Hz) (AT Fidelis Fotona, Ljubljana, Slovenia) with water irrigation was first used to remove subgingival calculus and infected cementum.The Er:YAG laser beam was delivered into the periodontal pockets using a chisel-shaped quartz tip in contact mode under water irrigation, from a coronal to an apical direction with the tip inclined at 10o to 15o to the root surfaces. After Er:YAG laser application, Nd:YAG laser treatment (AT Fidelis Fotona, Ljubljana, Slovenia) was performed at an energy level of 100 mJ/pulse, and 20 Hz for removing pocket epithelium and detoxiﬁcation purpose. Irradiation was accomplished with a 320 μm fiber optic delivery system. The fiber was inserted into the periodontal pocket base in parallel alignment with the root surface, and the fiber was slowly moved from apical to coronal in a sweeping motion during the laser light emission.
Sonic irrigation was performed using an EndoActivator sonic handpiece (Dentsply Tulsa Dental Specialties, Tulsa, OK, USA). A suitable-size activator tip was selected and loosely placed at 2 mm from working length, and the device was operated at 10,000 cycles/min using a pumping action to move the tip to produce vertical strokes of 2-3 mm.
In the intervention group the patients are allowed to eat only white meat and fish. They also need to increase their daily fiber intake to 50grams and drink 5 cups of coffee a day.
Well developed TB diagnostic testing, contact tracing, and treatment programs are key parts of the public health and health care infrastructure in many countries where HIV infection has resulted in a 3- to 10-fold increase in clinical TB, accompanied by increasing HIV prevalence. The primary purpose of this study is to construct a standardized diagnostic evaluation (SDE) for TB that provides an increase in identification of participants with active pulmonary TB, without sacrificing specificity.

This observational study will include participants who are HIV-infected and TB-uninfected and not receiving ARV therapy. The duration of this trial will last between 1 and 14 days. Screening and study entry may occur at the same visit. All evaluations must be performed within 14 days after the participant is registered. Medical and medication history, physical exam, oral examination and swab, chest x-ray, sputum and blood collection, and documentation of PPD/TST (if available) will occur within this 14-day period.
Arm I (exercise program): Oncologist advice; Resistance bands \& pedometer with written/DVD instructions for resistance exercise twice a week for 16 weeks. Brief moderate-intensity walks multiple times a day for a total of 30 minutes increasing steps weekly by 10% to reach a minimum of 10,000 steps a day. Monthly newsletters; Telephone counseling weekly for 4 weeks then monthly for 12 weeks; and tailored message telephone prompts once every 2 weeks during last 12 weeks of the study intervention.
BACKGROUND AND PURPOSE: Catalpol (CAT) has diverse pharmacological functions, including cellular homeostasis maintenance and anti-inflammatory effects. Sirtuin 5 (SIRT5) plays a considerable role in regulating cellular homeostasis in cardiac diseases. Our research explores the therapeutic potential of CAT against myocardial injury and its underlying mechanism.
METHODS: The H9c2 cells were pretreated with different CAT concentrations for 24 h, or CAT for 24 h followed by CoCl2 stimulation. Cell viability was determined with MTT assay. Biochemical assays, western blotting, and quantitative real-time PCR (qRT-PCR), combined with bioinformatic analysis, were used to examine the impact of CAT on CoCl2-induced myocardial injury in H9c2 cells and further explore its molecular mechanisms.
RESULTS: CAT ameliorated levels of myocardial enzymes, increased nicotinamide adenine dinucleotide (NAD+/NADH) ratio and adenosine triphosphate (ATP), while inhibited lactic acid (LD), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 in CoCl2-induced H9c2 cells. Mechanistically, SIRT5 knockdown inhibited Lin28a expression and negated the effects of CAT on ATP level, LD content, and the expression of inflammatory factors in cells. CAT likely exerted its protective effects on myocardial function through the SIRT5-mediated signaling pathway.
CONCLUSIONS: CAT regulates energy metabolism and inflammation via the SIRT5-mediated signaling pathway, exerting a protective effect in myocardial injury.