anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a compound oil-in-water cnidium fruit oil nanoemulsion composition. The particle size of the nanoemulsion composition is between 1 nm and 100nm. The nanoemulsion composition comprises the following raw materials in percentage by mass: 0.1 to 9.0 percent of cnidium fruit oil, 0.1 to 3.5 percent of eugenol, 0.1 to 2.0 percent of amitraz, 20.0 to 35.0 percent of surfactant, 0.1 to 6.0 percent of cosurfactant and the balance of distilled water, wherein the total percentage by weight of the raw materials is 100 percent. The compound cnidium fruit oil nanoemulsion has the effects of killing pests, relieving itching and killing bacteria and can be applied to the treatment of parasites (such as sarcoptic mites, psoroptidae, ticks, lice and the like) on body surfaces of animals. Through the compound oil-in-water cnidium fruit oil nanoemulsion composition, the stability and the bioavailability of the medicament are improved, the dosage of the medicament is reduced, the permeability is high, the insecticidal range is wide, the effect is obvious, and the preparation method is simple. Therefore, the compound oil-in-water cnidium fruit oil nanoemulsion composition is convenient to popularize and has wide market prospect in the field of medicaments.
Vancomycin hydrochloride for injection, USP, is a lyophilized powder, for preparing intravenous (IV) infusions, in Pharmacy Bulk Package bottles containing the equivalent of 5 g or 10 g vancomycin base. 500 mg of the base is equivalent to 0.34 mmol, 750 mg of the base is equivalent to 0.51 mmol, and 1 g of the base is equivalent to 0.67 mmol. When reconstituted with Sterile Water for Injection to a concentration of 50 mg/mL for the 5 g Pharmacy Bulk Package bottle and 100 mg/mL for the 10 g Pharmacy Bulk Package bottle, the pH of the solution is between 2.5 and 4.5. Vancomycin hydrochloride for injection, USP should be administered intravenously in diluted solution (see DOSAGE AND ADMINISTRATION).

Vancomycin hydrochloride is a chromatographically purified tricyclic glycopeptide antibiotic derived from Amycolatopsis orientalis  (formerly Nocardia orientalis) and has the molecular formula C66H75Cl2N9O24 ∙ HCl. The molecular weight is 1485.74.

Vancomycin Hydrochloride has the following structural formula:

Vancomycin hydrochloride is a white to tan lyophilized powder. When reconstituted with Sterile Water for Injection, USP, it forms a clear, light to dark tan solution. May contain hydrochloric acid and/or sodium hydroxide for pH adjustment. This product is oxygen sensitive.

The vancomycin hydrochloride pharmacy bulk package is a container of a sterile preparation for parenteral use that contains many single doses. The contents of this pharmacy bulk package are intended for use by a pharmacy admixture service for addition to suitable parenteral fluids in the preparation of admixtures for intravenous infusion (see DOSAGE AND ADMINISTRATION, Directions for Proper Use of Pharmacy Bulk Package). FURTHER DILUTION IS REQUIRED. NOT FOR DIRECT INFUSION.
The goal of mechanical ventilation in ARDS patients is to improve oxygenation by reducing the work of breathing . With this aim, the orientation towards sensitive ventilation strategies has increased in the light of experience and scientific data from the past to the present. Today, the concept of Mechanical Power (MP) has been developed, which combines different variables, such as tidal volume, drive pressure, gas flow, respiratory rate, and PEEP, which have been associated with VILI in various studies, into a single parameter. In this study, the investigators used the simplified MP equation (MPvcv (simpl)) developed by Gattinoni et al. for power calculation in volume control mode and the simplified MP equation (MPpcv(simpl)) developed by Becher et al. for power calculation in pressure control mode. Thus, the investigators aimed to compare the volume control and pressure control modes over the concept of MP.
This cohort includes individuals diagnosed with premature Acute Coronary Syndrome (ACS), including subtypes like unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI), and myocardial infarction with persistent ST-segment elevation (STEMI). These participants are under 55 years (men) or 65 years (women) and have been admitted to various cardiac facilities in Africa (Urban and rural) due to ACS-related symptoms.
In fractures, pain signals are transmitted from the dorsal root ganglion (DRG) to the brain, and the DRG generates efferent signals to the injured bone to participate in the injury response. However, little is known about how this process occurs. We analyzed DRG transcriptome at 3, 7, 14, and 28 days after fracture. We identified the key pathways through KEGG and GO enrichment analysis. We then used IPA analysis to obtain upstream regulators and disease pathways. Finally, we compared the sequencing results with those of nerve injury to identify the unique transcriptome changes in DRG after fracture. We found that the first 14 days after fracture were the main repair response period, the 3rd day was the peak of repair activity, the 14th day was dominated by the stimulus response, and on the 28th day, the repair response had reached a plateau. ECM-receptor interaction, protein digestion and absorption, and the PI3K-Akt signaling pathway were most significantly enriched, which may be involved in repair regeneration, injury response, and pain transmission. Compared with the nerve injury model, DRG after fracture produced specific alterations related to bone repair, and the bone density function was the most widely activated bone-related function. Our results obtained some important genes and pathways in DRG after fracture, and we also summarized the main features of transcriptome function at each time point through functional annotation clustering of GO pathway, which gave us a deeper understanding of the role played by DRG in fracture.
The present invention relates to a tablet structure, which mainly includes a bottom layer and a medicine body structure. The medicine body structure includes a shaping layer laid on the bottom layer and a medicine layer laid on the shaping layer. At least one through hole is formed on the shaping layer. The medicine layer is laid to form according to the configuration of the shaping layer. Using the method of depositing, stacking and adhering, the shaping layer is laid on the bottom layer and then the medicine layer is laid on the shaping layer. Therefore, coating can be performed according to the different ingredients of the tablet at the designated positions, and the multi-layered medicine body structure can be manufactured by the method of deposition, stacking and adhering, which is not only faster to manufacture, but also lower in cost.
PURPOSE:To obtain a hydrous powdery cosmetic, liquefiable by its injunction in use in spite of a cosmetic in the powdery form, exhibiting performances of the liquid type, providing excellent makeup effects and having advantages of both cosmetics of a powdery type and an O/W liquid type. CONSTITUTION:A hydrous powdery cosmetic is obtained by respectively mixing (A) hydrophobic silica having >=80m<2>/g surface area with (D) water and (B) cosmetic powder subjected to coating treatment with a fluorine compound, preferably cosmetic powder subjected to water and oil repellent treatment with a compound expressed by formula I or II (n is an integer of 6-18) with (C) an oily ingredient as essential ingredients, powdering the resultant mixture and mixing the prepared powder or mixing the ingredients (B) with (C), powdering the resultant mixture, then mixing the ingredient (A), further mixing the ingredient (D) and powdering the obtained mixture. The amounts of the ingredients based on the total composition are 0.1-7wt.% ingredient (A), 1-49.4wt.% ingredient (B), 0.5-30wt.% ingredient (C) and 50-90wt.% ingredient (D). The resultant hydrous cosmetic is capable of exhibiting excellent characteristics as follows. The above-mentioned performances are exhibited by the presence of the hydrous powder and oil-containing powder and natural luster, tenseness and adhesive feeling are provided. Uniform makeup films are formed with hardly any makeup disorder.
Cases of interstitial lung disease, some resulting in death, occurred in patients who received temsirolimus injection. Some patients were asymptomatic, or had minimal symptoms, with infiltrates detected on computed tomography scan or chest radiograph. Others presented with symptoms such as dyspnea, cough, hypoxia, and fever. Some patients required discontinuation of temsirolimus injection and/or treatment with corticosteroids and/or antibiotics, while some patients continued treatment without additional intervention. Patients should be advised to report promptly any new or worsening respiratory symptoms. 

It is recommended that patients undergo baseline radiographic assessment by lung computed tomography scan or chest radiograph prior to the initiation of temsirolimus injection therapy. Follow such assessments periodically, even in the absence of clinical respiratory symptoms. 

It is recommended that patients be followed closely for occurrence of clinical respiratory symptoms. If clinically significant respiratory symptoms develop, consider withholding temsirolimus injection administration until after recovery of symptoms and improvement of radiographic findings related to pneumonitis. Empiric treatment with corticosteroids and/or antibiotics may be considered. Opportunistic infections such as PJP should be considered in the differential diagnosis. For patients who require use of corticosteroids, prophylaxis of PJP may be considered.
Therapeutic anticoagulation showed inconsistent results in hospitalized patients with COVID-19 and selection of the best patients to use this strategy still a challenge balancing the risk of thrombotic and hemorrhagic outcomes. The present post-hoc analysis of the ACTION trial evaluated the variables independently associated with both bleeding events (major bleeding or clinically relevant non-major bleeding) and the composite outcomes thrombotic events (venous thromboembolism, myocardial infarction, stroke, systemic embolism, or major adverse limb events). Variables were assessed one by one with independent logistic regressions and final models were chosen based on Akaike information criteria. The model for bleeding events showed an area under the curve of 0.63 (95% confidence interval [CI] 0.53 to 0.73), while the model for thrombotic events had an area under the curve of 0.72 (95% CI 0.65 to 0.79). Non-invasive respiratory support was associated with thrombotic but not bleeding events, while invasive ventilation was associated with both outcomes (Odds Ratio of 7.03 [95 CI% 1.95 to 25.18] for thrombotic and 3.14 [95% CI 1.11 to 8.84] for bleeding events). Beyond respiratory support, creatinine level (Odds Ratio [OR] 1.01 95% CI 1.00 to 1.02 for every 1.0 mg/dL) and history of coronary disease (OR 3.67; 95% CI 1.32 to 10.29) were also independently associated to the risk of thrombotic events. Non-invasive respiratory support, history of coronary disease, and creatinine level may help to identify hospitalized COVID-19 patients at higher risk of thrombotic complications.ClinicalTrials.gov: NCT04394377.
PURPOSE: Pancreatic cancer (PDAC) is characterized by infiltrative, spiculated tumor growth into the surrounding non-neoplastic tissue. Clinically, its diagnosis is often established by magnetic resonance imaging (MRI). At the invasive margin, tumor buds can be detected by histology, an established marker associated with poor prognosis in different types of tumors.
METHODS: We analyzed PDAC by determining the degree of tumor spiculation on T2-weighted MRI using a 3-tier grading system. The grade of spiculation was correlated with the density of tumor buds quantified in histological sections of the respective surgical specimen according to the guidelines of the International Tumor Budding Consensus Conference (n = 28 patients).
RESULTS: 64% of tumors revealed intermediate to high spiculation on MRI. In over 90% of cases, tumor buds were detected. We observed a significant positive rank correlation between the grade of radiological tumor spiculation and the histopathological number of tumor buds (rs = 0.745, p < 0.001). The number of tumor buds was not significantly associated with tumor stage, presence of lymph node metastases, or histopathological grading (p ≥ 0.352).
CONCLUSION: Our study identifies a readily available radiological marker for non-invasive estimation of tumor budding, as a correlate for infiltrative tumor growth. This finding could help to identify PDAC patients who might benefit from more extensive peripancreatic soft tissue resection during surgery or stratify patients for personalized therapy concepts.
Ofatumumab was given intravenously on cycle 1 day 1 at a dose of 300mg, followed by a cycle 1 day 8 dose of 1000mg. During cycles 2 through cycle 6, Ofatumumab was given at a dose of 1000mg on day 1 of each cycle, with no dosing on any other day of the cycle. Bortezomib was given intravenously at a dose of 1.6mg/m2 on days 1, 8, and 15 of each cycle, following the Ofatumumab infusion, if given.
Human α2-antiplasmin (α2AP) is the major inhibitor of the proteolytic enzyme plasmin that digests fibrin. Two forms of α2AP circulate in human plasma: a 464-residue protein, which we have termed 'pro'-form, or α2APpro,and an N-terminally-shortened 452-residue 'activated'-form, or α2APact. The latter becomes crosslinked to fibrin by activated factor XIII about 5-fold more rapidly than α2APpro and makes fibrin resistant to digestion by plasmin. A new human plasma proteinase has been identified herein that cleaves the Pro12-Asn13 bond of α2APpro to yield α2APact. This enzyme is identified herein as Antiplasmin Cleaving Enzyme (APCE). Novel inhibitors of circulating APCE can diminish α2AP inhibitory capacity within forming fibrin or blood clots thereby making fibrin deposits or blood clots more susceptible to removal by plasmin. Patients who are susceptible to atherosclerotic plaque formation or are susceptible to developing thrombi that compromise organ function will benefit by therapies providing such inhibitors on a long term basis.
Single topical treatment administered to scalp and hair for 10 minutes. Applied at home by subject/caregiver.
The aim of present study was to compare two bone augmentation techniques (Guided Bone Regeneration, GBR, with autogenous block graft and GBR with particulate autograft plus xenograft) in terms of efficacy, complications, operational parameters (cost of the materials used, time for patient preparation, time for surgery, fatigue of the physician caused by surgery) tolerability by the patient and patient comfort. 30 systemically healthy individuals with inadequate alveolar bone crest width who requested implant placement (15 Female and 15 Male) participated in this study. After an initial examination, 15 patients were assigned to GBR with block graft (GBR-BG) and 15 were assigned to GBR particulate autograft plus xenograft (GBR-AX). Bone thickness was recorded before surgery and at a post-operative 6th month. Complications as Bleeding, Hematoma, Flap dehiscence, Infection, Numbness were evaluated. Patients were requested to record pain and swelling via visual analog scale (VAS) at 3rd, 7th and 14th days after surgery. The swelling was also recorded by an experienced clinician at 3rd, 7th and 14th days after surgery. Cost, time for patient preparation, time for surgery, fatigue of the physician caused by surgery were also determined.
PURPOSE:To provide an incense stick composition containing a chitosan salt as a binder and free from the drawbacks such as the nonuniformity of the quality of the product containing natural binder and the lowering of the flexural strength of the stick caused by the combined use of a mildewproofing agent inherent to a composition containing a synthetic binder. CONSTITUTION:Chitin separated from the crust of crab, shrimp, etc. is deacetylized with an alkali, and the obtained chitosan is made to react with an organic acid or an inorganic acid to obtain a chitosan salt, which is used as a binder of an incense stick composition. The conventional natural binder (powder of Machilus thunbergii) and/or synthetic binder can be replaced by this binder. Chitosan salts have excellent function as a binder, and can be used without using an assistant binder. The incense stick manufactured therefrom is easily ignitable, burns stably without extinguishing, and exhibits improved insecticidal activity or incense when used as a mosquito-repelling incense or perfume incense.
The invention provides a sustained-release temperature-sensitive blood vessel embolic gel used for treating tumor. The sustained-release blood vessel embolic gel is prepared by entrapping a medicine by using a pharmaceutically acceptable carrier. The medicine is an anti-tumor medicine, and the pharmaceutically acceptable carrier comprises a gel prepared from poloxamer polymer, polyvinyl pyrrolidone, and the like or a composition thereof. The polymer material accounts for 5-65% of a gel mass. The particle size of the gel is in a range of 10nm to 150mum. The embolic agent is liquid gel under normal temperature, and can be used for direct injection through catheter. After injection into body, with the increase of temperature, the liquid gel is rapidly solidified into gel. Also, according to requirements, different medicines can be entrapped, and embolism and medication dual effect can be achieved through local sustained-release. Therefore, the gel provided by the invention can be used as an embolic agent for endovascular treatment, and can be used in various benign and malignant tumor transcatheter arterial chemoembolizations. The preparation method provided by the invention is simple, and is suitable for industrialized productions.
The invention relates to a model for use in an imaging technique based on an interaction of the model with an electromagnetic radiation. The model comprises a plurality of volume elements. The interaction intensities of two neighboring volume elements are distinguishable by an imaging technique. The model comprises first volume elements made of a supporting material, and second volume elements are made of a supporting material and a contrast material and exhibit a higher interaction intensity with the electromagnetic radiation than the first volume elements because of the presence of contrast material. The second volume elements have been generated by a printing method. The invention further relates to a method for fabricating the model by 3D printing.
This study recruited patients with cervical cancer from the gynecological wards of a large-scale medical center in northern Taiwan. A total of 63 participants were divided into two groups. The control group (n=30) received routine sexual health teaching (a 10-15-minute routine individual sexual health education and a sexual health pamphlet without a gender-sensitive and theoretically based design. The experimental group (n=33) received the GS-SHEP (a 10-15-minute individual sexual health education and a sexual health pamphlet). GS-SHEP effectiveness was examined using a self-report instrument to measure background information and three dependent variables: "sexual knowledge," "sexual attitudes," "sexual self-efficacy", and "sexual activity". Data were collected at baseline, one week, six weeks, four months, and seven months after intervention and analyzed using the statistical software SPSS 20.0.
A clear gel cosmetic stick is disclosed which includes a liquid vehicle, an antiperspirant salt dissolved in the liquid vehicle, and a dibenzylidene alditol, and is further characterized in that said stick includes a hydroxyalkyl cellulose or a chelating agent or both a hydroxyalkyl cellulose and a chelating agent. The cosmetic stick comprises in percent by weight about 70 percent to about 95 percent, preferably 75 percent to 92 percent, of a liquid vehicle, about 1 percent to about 22 percent, preferably 3 percent to 15 percent, of an antiperspirant salt dissolved in said vehicle, about 0.5 percent to about 3 percent, preferably 0.5 percent to 1.5 percent, of a dibenzylidene alditol, about 0.1 percent to about 0.5 percent, preferably 0.2 percent to 0.4 percent, of a hydroxyalkyl cellulose, and about 0.05 percent to about 3 percent, preferably 0.1 percent to 2 percent, of a chelating agent. Preferably, the liquid vehicle comprises a polyhydric alcohol having from 3 to 6 carbon atoms and from 2 to 6 hydroxyl groups and is substantially free of monohydric alcohol and strong alkali such as sodium hydroxide and potassium hydroxide. Preferably, the cosmetic stick will have a pH greater than 4.4, more preferably greater than 4.7, a turbidity of less than about 120 NTU, more preferably less than 100 NTU, and a hardness of about 60 to 150. By lowering the dibenzylidene alditol level to 1.5 percent or lower, the clarity and odor characteristics of the stick are greatly improved. The hardness of the stick is maintained by the addition of the hydroxyalkyl cellulose. The color of the stick is improved by the addition of the chelating agent.
PURPOSE: To investigate the therapy effect of minimally invasive fourth-ventricle hematoma removal (MIFHR) for patients with intraventricular hemorrhage (IVH) casting and the influence of feedback early rehabilitation on post-operative neurological function.
METHODS: Eighty patients with IVH casting were enrolled from January 2019 to December 2020 in this retrospective study. Forty patients receiving MIFHR with feedback early rehabilitation were divided into the observational group, while the others receiving bilateral external ventricular drainage with traditional rehabilitation were divided into the control group. Glasgow Coma Scale (GCS) and neurological function before and after operation were compared between the two groups. In addition, hematoma clearance rate three days after surgery, drainage duration, hospitalization time, motor function and activity daily living (ADL) six months after surgery, and incidence of complications were also compared.
RESULTS: No significant differences were observed in GCS score and neurological function before surgery between the two groups (both P > .05). At the same time, there were significant differences GCS score and neurological function after surgery (both P < .05). Hematoma clearance rate three days after surgery, drainage duration, hospitalization time, and incidence of complications in the observational group were lower than those in the control group (all P < .05). In contrast, motor function and ADL six months after surgery were better in the observational group (both P < .05).
CONCLUSION: MIFHR combined with feedback early rehabilitation is conducive to the recovery of neurological function, motor function, and ADL without increasing the incidence of complications.
Quadratus lumborum block is an effective truncal block for postoperative analgesia in patients undergoing abdominal surgeries. We aimed to compare the analgesic efficacy of caudal block versus ultrasonography-guided quadratus lumborum block in pediatric patients undergoing open pyeloplasty. Fifty patients weighing ≤ 16 kg (age ≤ 4 years) with ASA physical status I-II scheduled for elective open pyeloplasty under general anesthesia were randomized into caudal block or transmuscular quadratus lumborum block groups. Fifty patients were included in the analysis. The mean duration of postoperative analgesia in the caudal group was 6.85 ± 1.99 hr, and for the quadratus lumborum block group it was 11.27 ± 3.74 hr (P < .001). There was no significant difference between the groups in terms of perioperative fentanyl requirement. However, there was a significant difference in postoperative paracetamol requirement between the groups (P = .005). There was a significant difference in postoperative pain score between the groups at 30 min, 1 hr, 1.5 hr, 2 hr, 8 hr, and 24 hr (P < .05). Mean heart rate and mean arterial pressure were comparable. No complications were recorded. Quadratus lumborum block was more effective than caudal block in terms of duration of postoperative analgesia and postoperative analgesic consumption.