anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Compositions, methods, and kits for cosmetically producing a tanned appearance in desired areas of skin. The composition includes a self-tanning agent together with intimately admixed fluorescent materials in a cosmetic carrier. Without prolonged exposure to intense solar or artificial radiation, applying the self-tanning agent imparts a tanned appearance which develops several hours to a day after application. The fluorescent materials absorb at one frequency, and emit at another visible frequency. The admixture of self-tanning agent and fluorescent materials allows application of the self-tanning agent selectively to desired areas of the skin. A light source which emits at the absorbing frequency of the fluorescent materials may be provided together with the compositions in kit form. By illuminating the skin after the composition has been applied and before the self-tanning agent develops its color, any coverage of undesired areas may be easily removed, and any desired areas which were unintentionally untreated may be detected and subject to reapplication.
The aim of this study was to develop a machine-learning prediction model for AKI after craniotomy and evacuation of hematoma in craniocerebral trauma. We included patients who underwent craniotomy and evacuation of hematoma due to traumatic brain injury in our hospital from January 2015 to December 2020. Ten machine learning methods were selected to model prediction, including XGBoost, Logistic Regression, Light GBM, Random Forest, AdaBoost, GaussianNB, ComplementNB, Support Vector Machines, and KNeighbors. We totally included 710 patients. 497 patients were used for the training of the machine learning models and the remaining patients were used to test the performance of the models. In the validation cohort, the AdaBoost model got the highest area under the receiver operating characteristic curve (AUC) (0.909; 95% CI, 0.849-0.970) compared with other models. The AdaBoost model showed an AUC of 0.909 (95% CI, 0.849-0.970) in the validation cohort. Although there was an underestimated acute kidney injury risk for the model in the calibration curve, there was a net benefit for the AdaBoost model in the decision curve. Our machine learning model was evaluated to have a good performance in the validation cohorts and could be a useful tool in the clinical practice.
Study participants having finished the following course in the past will be assigned to the intervention group: During a 6-module course, with four 3-day modules and two 5-day modules in the timeframe of one year, participants learn ways to strengthen their personal resources to establish effective social relationships and to develop skills as a social being. In between the module courses, the participants take 5 single sessions with an instructed trainer and document 10 conversations/social situations where they successfully applied the new skills.
Diabetic peripheral neuropathy is a common and highly prevalent complication of type 2 diabetes mellitus, posing a significant global health concern. It affects a considerable number of individuals with diabetes, leading to progressive nerve damage and functional impairments. The multifaceted nature of this condition manifests in various ways, including sensory, motor, and autonomic dysfunction. Its insidious onset and gradual progression impose a substantial burden on patients, reducing their quality of life and presenting significant challenges for healthcare providers. Therefore, understanding the underlying causes, mechanisms, and management strategies of diabetic peripheral neuropathy is essential to alleviate its impact and enhance the overall well-being of those affected by this condition. Patients with diabetic peripheral neuropathy encounter a range of distressing symptoms that profoundly influence their daily activities. Sensory manifestations, such as numbness, tingling, and pain, are common, especially among older individuals with diabetes. Challenges in detecting temperature and touch also increase the risk of burns or injuries. Motor neuropathy results in muscle weakness, loss of balance, and coordination difficulties, making simple tasks like walking or holding objects more challenging. Furthermore, diabetic peripheral neuropathy plays a significant role in falls among elderly patients due to balance disorders and proprioception impairment. To address these issues and improve patients' quality of life, exercise has emerged as a valuable therapeutic intervention. Regular exercise programs, specifically those incorporating balance training exercises, have shown promising outcomes in enhancing balance and reducing falls among those with diabetic peripheral neuropathy. By emphasizing a comprehensive approach to exercise, targeting proprioception, coordination, and lower limb strength, patients can benefit from improved sensory integration, enhanced muscle control, and postural stability, ultimately promoting greater independence and reducing the risk of falls. Through a well-designed randomized controlled trial, exploring the effectiveness of a multisystem exercise program, further advancements in managing diabetic peripheral neuropathy can be achieved, leading to improved patient outcomes and enhanced quality of life.
XELOX: Oxaliplatin 100mg/m2 d1 Intravenous infusion, every 3 weeks. Capecitabine 850mg/m\^2 bid, days 1-14, every 3 weeks, until progression/intolerance.
The present study is designed to enhance the delivery of growth factors and anti-inflammatory agents to localized targets (determined by specific condition) by using focused transcranial ultrasound prior to intravenous infusion of exosomes. Exosomes, which are ubiquitous in blood, body fluids, and tissues are thought to play a normal physiological role in intercellular signaling. Exosomes delivered intravenously can be demonstrated to cross the blood brain barrier naturally. Exosomes and mesenchymal signaling cells (MSC's) demonstrate anti-inflammatory and pro-growth effects in preclinical models and clinical cases reports and have been used intravenously and with intracerebral and intrathecal injection. Various clinical trials have claimed safety and clinical efficacy.

Focused ultrasound has been demonstrated to enhance local blood flow and has been proposed as a non-invasive means of targeting delivery of therapeutic agents. The present paper was designed to use focused ultrasound as a means of enhancing delivery of intravenous exosomes to the subgenual target for patients with refractory depression, the amygdala for patients with anxiety, and the hippocampus for patients with cognitive impairment due to neurodegenerative disease.
A man in his 80s was undergoing immunotherapy with pembrolizumab, an anti-PD-1 monoclonal antibody, following his diagnosis of adenocarcinoma of primary lung origin. 24 weeks into treatment, the patient reported experiencing loose stools associated with malaise and poor appetite but no further symptoms. This progressed in frequency and a clinical diagnosis of grade 2 immune checkpoint inhibitor colitis was made. Management with oral prednisolone was commenced but symptoms persisted. Common enteric infections had been ruled out, as were coeliac disease and hyperthyroidism. Flexible sigmoidoscopy and colonoscopy results were not in keeping with colitis, having revealed normal looking mucosa. Following this, a faecal elastase level was found to be low. A diagnosis of pembrolizumab-induced pancreatic exocrine insufficiency was made, and stool frequency and consistency swiftly improved following the use of pancreatic enzyme replacement therapy.
Patients with renal failure, with creatinine clearance between 60 and 15 ml/min. A blood sample is achieved at 0, 1, 3 and 6 months.
There have been reports of long coronavirus disease (long COVID) and breakthrough infections (BTIs); however, the mechanisms and pathological features of long COVID after Omicron BTIs remain unclear. Assessing long-term effects of COVID-19 and immune recovery after Omicron BTIs is crucial for understanding the disease and managing new-generation vaccines. Here, we followed up mild BA.2 BTI convalescents for six-month with routine blood tests, proteomic analysis and single-cell RNA sequencing (scRNA-seq). We found that major organs exhibited ephemeral dysfunction and recovered to normal in approximately six-month after BA.2 BTI. We also observed durable and potent levels of neutralizing antibodies against major circulating sub-variants, indicating that hybrid humoral immunity stays active. However, platelets may take longer to recover based on proteomic analyses, which also shows coagulation disorder and an imbalance between anti-pathogen immunity and metabolism six-month after BA.2 BTI. The immunity-metabolism imbalance was then confirmed with retrospective analysis of abnormal levels of hormones, low blood glucose level and coagulation profile. The long-term malfunctional coagulation and imbalance in the material metabolism and immunity may contribute to the development of long COVID and act as useful indicator for assessing recovery and the long-term impacts after Omicron sub-variant BTIs.
Patients with diagnosis of OCD as confirmed by x-ray or MRI. Surveys collected from patients at 2 years, 5 years, 10 years, and 25 years.
INTRODUCTION: A group of SARS-CoV-2 infected individuals present lingering symptoms, defined as long COVID (LC), that may last months or years post the onset of acute disease. A portion of LC patients have symptoms similar to myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), which results in a substantial reduction in their quality of life. A better understanding of the pathophysiology of LC, in particular, ME/CFS is urgently needed.
METHODS: We identified and studied metabolites and soluble biomarkers in plasma from LC individuals mainly exhibiting ME/CFS compared to age-sex-matched recovered individuals (R) without LC, acute COVID-19 patients (A), and to SARS-CoV-2 unexposed healthy individuals (HC).
RESULTS: Through these analyses, we identified alterations in several metabolomic pathways in LC vs other groups. Plasma metabolomics analysis showed that LC differed from the R and HC groups. Of note, the R group also exhibited a different metabolomic profile than HC. Moreover, we observed a significant elevation in the plasma pro-inflammatory biomarkers (e.g. IL-1α, IL-6, TNF-α, Flt-1, and sCD14) but the reduction in ATP in LC patients. Our results demonstrate that LC patients exhibit persistent metabolomic abnormalities 12 months after the acute COVID-19 disease. Of note, such metabolomic alterations can be observed in the R group 12 months after the acute disease. Hence, the metabolomic recovery period for infected individuals with SARS-CoV-2 might be long-lasting. In particular, we found a significant reduction in sarcosine and serine concentrations in LC patients, which was inversely correlated with depression, anxiety, and cognitive dysfunction scores.
CONCLUSION: Our study findings provide a comprehensive metabolomic knowledge base and other soluble biomarkers for a better understanding of the pathophysiology of LC and suggests sarcosine and serine supplementations might have potential therapeutic implications in LC patients. Finally, our study reveals that LC disproportionally affects females more than males, as evidenced by nearly 70% of our LC patients being female.
The patients in the experimental group received acupressure application for a total of 8 sessions, 2 sessions per week. The first application was performed in a room in the polyclinic by a researcher with an acupressure application certificate. Immediately after the preparation phase, the researcher applied acupressure with the thumb in a certain order (Ht7-Ht7 and St36-St36) on each point to be pressed, in accordance with the acupressure application protocol, for a duration of 2 minutes. Verbal communication was maintained during the procedure to ensure the patient's relaxation. After the first application, the application was taught to the patient. In addition, the researcher established a WhatsApp group for regular follow-up of the patients in the experimental group, and the video recording of the acupressure was sent to the patients and they were asked to watch it.
In order to improve preservation of the structure and functions of human and animal stem cells with varying levels of differentiation and of highly differentiated tissue cells during  in vitro  and  ex vivo  culturing and during cryopreservation and long-term storage under standard and extreme conditions, culturing media are used that correspond to the cell type in question and to which one or more gels of varying density are added that contain a submicron emulsion of chemically and metabolically inert perfluoroorganic compounds (PFOC). PFOC gel structures perform the function of a skeleton and at the same time imitate the intercellular matrix and thus may serve as a substrate and gas exchange medium. The gels are composed of emulsions of individual PFOCs or emulsions of mixtures of PFOCs, the dispersion of which is stabilised by non-ionising surfactants (NIS) based on block copolymers of polyethylene oxide and polypropylene oxide and derivatives thereof of different molecular weights and component ratios. Depending upon their density, gels containing submicron emulsions of PFOCs may advantageously be used for the culturing, storage or cryopreservation of cells according to their density. Gel density may be reduced by introducing a saline solution medium containing low-molecular weight osmolytes, and conversely the density of the gel may be increased by increasing the concentration of basic components, i.e., PFOCs and NISs, by partial lyophilisation and/or by centrifuging. Cell cultures in suspension and in monolayer growth following cryopreservation, storage or culturing in PFOC-containing gels have a viable cell average of 90% and are easily removed from the substrate gels, sub-culture under standard conditions, divide, and preserve full functionality and their differentiating capabilities.
The invention relates to medicinal wine used for treating constipation. The medicinal wine is characterized in that the wine is prepared from the raw materials of, by weight: 40-60 parts of rehmannia juice, 50-60 parts of ginger juice, 100-120 parts of suet, 200-250 parts of medlar, 100-120 parts of hemp seed, 70-80 parts of white honey, 20-30 parts of licorice root, and 800-1200 parts of glutinous rice wine. During preparation, medlar, hemp seed, and licorice root are crushed; 1000ml of water is added, and the mixture is decocted until 500ml is left; the glutinous rice wine is boiled by using a mild fire, while suet is added during boiling; when suet is dissolved, rehmannia juice, ginger juice, and the 500ml of medicine liquid are added; the mixture is well mixed, and is boiled tens of times; the mixture is fetched from heat, and is to be cooled; white honey is refined, and is well mixed in the wine; the mixture is sealed and soaked for 3 days, such that the wine is obtained. When in use, approximately 20-30ml of the product is used each time, and is orally taken with empty stomach; and the wine is taken three times a day. The medicinal wine is reasonably formulated, and is convenient to use. The wine has the functions of spleen nourishing, qi benefiting, middle warmth regulating, appetite promoting, dryness eliminating, and constipation eliminating.
INTRODUCTION: Amongst low- to middle income countries (LMIC), outdated and poorly documented orthopedic interventions may pose patients at risk for complications, serious adverse events (SAE) and unsatisfactory results, contradicting the World Health Organization's (WHO) Safe Surgery mandates. Use cases of conditions managed inadequately in LMIC environments are necessary to increase awareness of stakeholders and overcome deficiencies in collaboration with high-income countries (HIC).
MATERIALS AND METHODS: Methodological and clinical experts from the BG Kliniken and the Charité, Berlin, Germany, were invited to investigate established processes for musculoskeletal disorders and injuries in Tashkent, Uzbekistan. Congenital lower leg discrepancy due to fibular hemimelia was recognized as an illustrative example to prove the effectiveness of local treatment guidelines, still relying on distraction epiphyseolysis (chondrodiatasis) via an Ilizarov frame. Routine data from hospital records, images and outpatient follow-up examinations were compared to estimates from a review of studies of limb-lengthening by other techniques.
RESULTS: Data from 16 of 49 immature patients (10 males, 6 females, mean age at surgery, 4.2 ± 2.3 years) undergoing chondrodiatasis between 2017 and 2021 showed a mean limb elongation of 2.4 (95% confidence interval [CI], 1.9 to 2.9) cm after a median follow-up of 29 (range, 24 to 36) months. While no complications or SAE were noted, findings are compatible with a risk of 21% under an upper 97.5% confidence limit for null events. No reproducible classification of hemimelia, surgical or general complications, assessment of functional outcomes or health-related quality of life were available. The pooled average length gain from 21 studies on different other interventions with osteotomy enrolling 458 limbs was 5.1 (95% CI, 5.0 to 5.3) cm.
CONCLUSIONS OF THE USE CASE: Limb lengthening for hereditary fibular hemimelia in Uzbekistan revealed rather obsolete surgical algorithms, inadequate documentation, and unreliable outcome assessment. Resource limitations notwithstanding, knowledge transfer, implementation of current procedures and hardware, and international collaboration is vital to improve quality of care in this scenario and for the benefit of LMIC in general.
PURPOSE: A composition for cold fomentation having a freezing characteristic in a gel state obtained by addition of an antifreeze material and a highly absorbable polymer to water and a fomenting pack filled with the composition are provided. Therefore, the fomenting pack can be applied to the affected part having various shapes because the composition freezes in a soft gel state when applied to the part. CONSTITUTION: The composition for cold fomentation comprises 55 to 79% by weight of water, 20 to 40% by weight of an antifreeze material and 1 to 5% by weight of a polymer as one of hydrated polyacrylonitrile, carbohydrate acrylic copolymers or a mixture of polyacrylate and polyacrylamide. The antifreeze material is one of glycerine or propylene glycol. The fomenting pack containing the composition consisting of: one or more fomenting parts(1) containing the fomenting composition and applying to the affected part; a fixing part(5) fixing the fomenting parts; and a connecting part(3) mutually connecting each fomenting part. The fomenting pack has the advantage of capable of being used by refreezing when the composition is thawed.
<P>PROBLEM TO BE SOLVED: To provide a method for producing an extraction component composition of a salmon ovary membrane administrable by percutaneous administration to develop the effect comparable or superior to oral administration.  <P>SOLUTION: The ovary membrane of salmon is treated with the first proteinase to extract the first component. The first component is treated with the second proteinase different from the first proteinase to obtain the second component having a molecular weight lower than the first component. Preferably, the method is further provided with the treatment of the second component with an ultrahigh-pressure emulsifier under a pressure of 980-2,940 MPa to obtain particles having an average particle diameter of 200-1,400 nm. The second proteinase is selected from the group comprising a proteinase composed of a mixture of a plurality of endoproteases and exoproteases produced by an actinomycete, papain, and protease K, especially preferably a mixture of a plurality of endoproteases and exoproteases produced by an actinomycete.  <P>COPYRIGHT: (C)2009,JPO&INPIT
PURPOSE:To obtain a trichogenic promoter, by blending a ginger juice with black sesame juice and vitamin E in a specific proportion in use, capable of sufficiently exhibiting efficacy of each ingredient, producing hair from a bald head by synergistic effect thereof and further growing black hair. CONSTITUTION:A trichogenic promoter obtained by blending each individually preserved ginger juice with black sesame juice and vitamin E at 1:0.9989:0.0011 weight ratio in use. Just after blending, the promoter is sprinkled on an affected part to massage to part. The moderate irritation of the ginger juice is imparted to the skin to improve the blood circulation and enhance the skin function. Thereby hair roots are strengthened and growth of the hair is promoted. The black sesame juice simultaneously permeates from the skin pores into the hair roots to activate hormones in the skin, stimulate enzymes and convert tyrosine into melanin, which is diffused into the hair roots to produce black hair. Furthermore, vitamin E enlarges peripheral blood vessels to regulate the gonadal function.
Tetrahydrolinalool (THL) is an acyclic monoterpene alcohol, produced during linalol metabolism and also a constituent of essential oils. As described in the literature, many monoterpenes present anticonvulsant properties, and thus we became interested in evaluating the anticonvulsant activity of Tetrahydrolinalool using in mice model as well as in silico approaches. Our results demonstrated that THL increased latency to seizure onset and also reduced the mortality, in picrotoxin induced seizure tests. The results may be related to GABAergic regulation, which was also suggested in seizure testing induced by 3-mercapto-propionic acid. In the strychnine-induced seizure testing, none of the groups pretreated with THL modulated the parameters indicative of anticonvulsant effect. The electrophysiological results revealed that THL treatment reduces seizures induced by pentylenetetrazole. The in silico molecular docking studies showed that the interaction between THL and a GABAA receptor model formed a stable complex, in comparison to the crystaligraphic structure of diazepam, a structurally related ligand. In conclusion, all the evidences showed that THL presents effective anticonvulsant activity related to the GABAergic pathway, being a candidate for treatment of epileptic syndromes.
Cervical cancer is a preventable disease that continues to burden socioeconomically underserved regions, especially in Africa. Vaccination of adolescents who have never had sex with prophylactic human papillomavirus (HPV) vaccines proves effective in preventing the disease. However, vaccine accessibility and availability are two persistent challenges in low-resource settings. For this commentary, a trend analysis is conducted for national HPV vaccination and coverage rates in Africa, a region with high burden of the disease. This is in consideration of the World Health Organization (WHO) strategy to vaccinate 90% of adolescent girls by the age of 15, as part of strategy to eliminate cervical cancer by 2030. The analysis estimated that the rate of incorporating HPV vaccination in national immunization programs in Africa occurs slowly, at a mean wait time of 12 years with estimated coverage rate of 52%. A policy change that harnesses strategic approaches, such as a regionalized vaccination program, is recommended to hasten HPV vaccination for the rest of African countries without a national program.
A Chinese medicinal fumigant containing high content of high-activity scleratogenous factor is used to replace oral medicine. A fumigating bed with stepless regulation of heat is used for optimal concentration of medicinal vapour and higher curative effect. The temp. of medicinal vapour is as same as the highest temp. able to be resisted by the patient, so it can directly come to disease focus without resistance. Said fumigant and bed are suitable for bone fracture patients with magic curative effect.