anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide a reagent that is useful for a diagnostic assay associated with mycobacteria infection and contains mycobacteria and a mycobacterium membrane-associated polypeptide or a DNA encoding the polypeptide.  <P>SOLUTION: Nucleic acids encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. The BCG DNA insert of one of the recombinants, pMBB51A, expressing an antigen of Mr90kD, was sequenced completely and an ORF encoding 761 amino acids encoding a protein of deduced molecular weight 79 kD, was identified. This gene was identified to encode a membrane bound, ion-motive ATPase of M. bovis BCG. The well-characterized M. bovis BCG antigens can be used in the prevention, diagnosis and treatment of tuberculosis.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Female BRCA mutation carriers can opt for early salpingectomy upon completion of childbearing, followed by second stage oophorectomy delayed for five years beyond current guideline ages for risk-reducing salpingo-oophorectomy (i.e. age 40-45 for BRCA1 mutation carriers and 45-50 for BRCA mutation carriers).
The overall aim of this proposal is to investigate the potential short and long term effectiveness of a cognitive training program Goal-Oriented Attentional Self-regulation (GOALS) that targets executive control functions in Veterans with co-morbid posttraumatic stress disorder (PTSD), history of mild traumatic brain injury (mTBI), and cognitive difficulties. Both PTSD and a history of mild TBI are prevalent in Veterans from the Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF) conflicts, with reported rates for each disorder ranging from 14 - 22%. Both PTSD and TBI have been associated with cognitive dysfunction which may lead to functional impairment and poor community reintegration. PTSD can be highly debilitating not only due to emotional dysregulation, but also due to deficits in the cognitive control processes.

Goal-Oriented Attentional Self-Regulation (GOALS) is a therapist administered cognitive rehabilitation training that targets executive control functions of applied mindfulness-based attention regulation and goal management, and links them to participant-defined real-life goals. In a prior study with individuals with chronic brain injury, this training has improved cognitive performance in areas of complex attention / executive function, memory, complex functional task performance, and daily functioning. Furthermore, functional MRI results after training indicated significantly enhanced modulation of neural processing in extrastriate cortex and changes in prefrontal cortex. Preliminary results from a recently completed study with Veterans with a history of chronic TBI also support improvements post GOALS on neuropsychological measures of attention and executive function, performance on complex 'real-life' tasks, and self-report measures of functional performance. Furthermore, participants also showed improvement on the emotional regulation self-report measures. These findings suggest that improving cognitive control may also improve functioning in other domains such as emotional regulation and functional performance in daily life.

In a randomized, controlled intervention study design, 42 Veterans with a diagnosis of PTSD, history of mTBI and residual cognitive difficulties will participate in experimental (GOALS), and/or active comparison (Brain Health Education - EDU) interventions matched for time and intensity. Participants will be randomized to start with either 5 weeks of GOALS or EDU training. Those who begin with EDU will cross-over to GOALS, while those begin with GOALS will have 5 weeks of self-driven practice only. Both groups will participate in pre and post intervention measurements at baseline, weeks 5 and 10. Long-term follow-up will be at 6 months. Pre- and post-intervention measurements will include performance on untrained: neuro-cognitive tests assessing targeted and non-targeted cognitive domains, complex functional task performance in low structure 'real-world' setting, and self-report measures of emotional regulation and daily functioning.
A retrospective analysis of disease histories for the period from 2014 to 2021 was carried out. Data collection was carried out at all stages of treatment: medical and nursing brigade, military mobile hospital, military medical clinical center, during rehabilitation, within 12 months of the injury. The basic tool for pain intensity research was the VAS. The study of the neuropathic component of pain was carried out using the DN4. Study of the presence of an acute stress reaction - anamnesis + HADS. The diagnosis of ASR was established by a psychiatrist upon admission to the military mobile hospital. The presence of post-traumatic stress disorders (PTSD) was investigated using the Mississippi scale of post-traumatic stress disorders (military version). The presence of PTSD according to the MS PTSD (c). Satisfaction with treatment results was studied using the Chaban Quality of Life Scale.
Muscle function and exercise performance measures, such as muscle endurance capacity, maximal strength, chair stand score, gait speed, and Timed Up and Go score, are evaluated to diagnose sarcopenia and frailty in older individuals. Furthermore, intramuscular adipose tissue (IntraMAT) content increases with age. Skeletal muscle oxidative capacity determines muscle metabolism and maintains muscle performance. This study aimed to investigate the association of skeletal muscle oxidative capacity with muscle function, exercise performance, and IntraMAT content in older individuals. Thirteen older men and women participated in this study. Skeletal muscle oxidative capacity was assessed by the recovery speed of muscle oxygen saturation after exercise using near-infrared spectroscopy from the medial gastrocnemius. We assessed two muscle functions, peak torque and time to task failure, and four sarcopenia-related exercise performances: handgrip strength, gait speed, 30-s chair stand, and Timed Up and Go. The IntraMAT content was measured using axial magnetic resonance imaging. The results showed a relationship between skeletal muscle oxidative capacity and gait speed but not with muscle functions and other exercise performance measures. Skeletal muscle oxidative capacity was not related to IntraMAT content. Skeletal muscle oxidative capacity, which may be indicative of the capacity of muscle energy production in the mitochondria, is related to locomotive functions but not to other functional parameters or skeletal fat infiltration.
There will be 8 children in this arm. These children will receive placebo instead of the active medication.
This is a multicenter pragmatic prospective observational study including Nordic hospitals treating patients with borderline resectable and locally advanced pancreatic cancer. Eligibility will be assessed at regional multidisciplinary tumor boards. Patients with borderline resectable and locally advanced (non-endocrine) pancreatic cancer according to the National Comprehensive Cancer Network (NCCN) and the International Study Group of Pancreatic Surgery (ISGPS) are eligible for inclusion. The study is observational. Quality of life will be assessed in all study participants. The primary outcomes are exploration rates, resection rates and overall survival.
<P>PROBLEM TO BE SOLVED: To provide a cosmetic good in feeling in use as a foam cosmetic or pack cosmetic.  <P>SOLUTION: The foaming cosmetic contains (1) xanthan gum and (2) quince seed extract. As a formulation of this cosmetic, an aerosol cosmetic extruding foam together with gas is preferable. This cosmetic is preferably a pack cosmetic. Owing to a combination of the above two ingredients(1) and (2), this cosmetic gives foam of high firm texture and stability, and such foam properties improve feeling in use of the cosmetic.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Bleeding and/or spotting that occurs at any time while the vaginal system is inserted is considered “unscheduled” bleeding/spotting. Bleeding/spotting that occurs during the dose-free week when the vaginal system is out is considered “scheduled” bleeding. 

Unscheduled and Scheduled Bleeding and Spotting

Females using ANNOVERA may experience unscheduled (breakthrough) bleeding and spotting, especially during the first month of use. If unscheduled bleeding persists or occurs after previously regular cycles on ANNOVERA, check for causes such as pregnancy or malignancy. If pathology and pregnancy are excluded, bleeding irregularities may resolve over time or with a change to a different CHC. 

Based on subject diaries from the two clinical efficacy trials of ANNOVERA [see Clinical Trial Experience (6.1)], 5–10% of females experienced unscheduled bleeding per 28-day cycle. The average number of days with unscheduled bleeding and/or spotting, in Treatment Cycles 1 to 13 for those females who experienced unscheduled bleeding and/or spotting, was 1 day or less per cycle. A total of 41 subjects (1.7%) discontinued use due to menstrual disorders including metrorrhagia, menorrhagia, and abnormal withdrawal bleeding. 

Amenorrhea and Oligomenorrhea

Females who are not pregnant and use ANNOVERA may experience amenorrhea. Based on subject diary data from two clinical trials for up to 13 cycles, amenorrhea occurred in 3–5% of females per cycle using ANNOVERA and in 0.9% of females in all 13 cycles. 

If scheduled bleeding does not occur, consider the possibility of pregnancy. If the patient has not adhered to the prescribed dosing schedule (removed vaginal system for >2 hours during the first 21 days or does not replace after 7 days of vaginal system-free period), consider the possibility of pregnancy at the time of the first missed period and perform a pregnancy test. If the patient has adhered to the prescribed dosing schedule and misses 2 consecutive periods, perform a pregnancy test to rule out pregnancy. 

Some females may experience amenorrhea or oligomenorrhea after stopping ANNOVERA, especially when such a condition was pre-existent.
ABSTRACT           Amido substituted naphthalene compounds of the formula:          where:        R1 may be C1-12 alkyl, C3-12 branched-chain alkyl, C2-6 alkenyl, C3-6 alkynyl, or an aralkyl wherein the alkyl group is C1-3  unsubstituted or substituted with C1 2 alkyl or hydroxyalkyl, wherein the alkyl group is C1-6;        R2 may be H, C1-10 alkyl, C3-10 branched-chain alkyl, C5-7 cycloalkyl, phenyl or phenyl substituted by C1-3 alkyl or C1-3 alkoxy;         R3 may be H or C1-3 alkyl; and (CH2)n may be a straight- or branched-alkyl chain of 0-5 carbons.  Intermediates of the compound of formula I having the formula:                             I I   where R1 and (CH2)n are as defined above.  R1 may also be H and R4 may be H or C1-3 alkyl with the proviso that when (CH2)n is an alkyl chain of 0-2 carbons, R1 is not C1-2 alkyl.  The compounds of formula I or II are useful as anti-inflammatory agents.  The compounds inhibit the cyclooxygenase pathway and may additionally inhibit the lipoxygenase pathway.  In particular the amido substituted naphthalenes are pharmacologically active in alleviating inflammation, asthma, hyper-sensitivity, myocardial ischemia, dermatological conditions such as psoriasis, and dermatitis and gastrointestinal inflammatory conditions such as inflammatory bowel syndromes.  Processes of preparing these compounds, compositions containing same and medical treatments using them are also disclosed.
A functionalized nanomaterial, such as a nanoparticle, can include a polythioaminal functionalized surface. The polythioaminal linked to the surface of the nanomaterial can be bonded to a compound such as therapeutic and/or diagnostic materials. The thiol-based linkages can be used to bond the polythioaminal to both the nanomaterial and the therapeutic and/or diagnostic materials. Polythioaminals can be prepared via reactions of triazine and dithiols. Polythioaminals thus prepared can be further modified to provide linkages to the nanomaterial and other compounds such as medicinal compound, peptides, and dyes. Nanomaterials including such compounds linked thereto via the polythioaminal can be supplied for therapeutic and/or diagnostic purposes to biological target regions.
INTRODUCTION: Immunocompromised persons are at high risk of persistent Human Papilloma Virus (HPV) infection and associated diseases. Few studies evaluated HPV vaccines in immunocompromised persons. This study aimed to evaluate the quadrivalent HPV vaccine (4vHPV) immunogenicity and safety in solid organ transplant (SOT) recipients, in comparison to immunocompetent women (IC).
METHODS: Open-label clinical trial that enrolled SOT recipients and immunocompetent women aged 18 to 45 years. All participants received three doses of 4vHPV vaccine. Blood samples were drawn for evaluation of immune responses at baseline and one month after the third vaccination. Seroconversion rates and antibody geometric mean concentration (GMC) against HPV 6, 11, 16, 18, 31, 35, 52 and 58 were measured with in-house multiplexed serology assay (xMAP technology). Follow-up for the local and systemic adverse events (AEs) continued for seven days after each vaccination. Severe AEs were evaluated throughout the study.
RESULTS: 125 SOT and 132 immunocompetent women were enrolled; 105 (84%) SOT and 119 (90%) immunocompetent women completed the study. At baseline, HPV seropositivity was not significantly different between groups. Seroconversion rates were significantly lower in SOT (HPV18, 57%; HPV6 and 16, 69%; and HPV11, 72%) than in immunocompetent women (100% seroconversion to all vaccine types) (p<0.001). Antibody GMCs of all four HPV vaccine types were also significantly lower in SOT (p<0.001). Pain in the injection site and headache were the most frequent adverse event in both groups. Local pain was more frequent in immunocompetent women than in SOT recipients. Rates of other AEs were comparable in both groups.
CONCLUSION: 4vHPV vaccine was well-tolerated by SOT recipients. We found strong evidence of lower humoral immune responses to 4vHPV vaccine in SOT compared to immunocompetent women, which strengthen recommendation of routine cervical cancer screening in SOT recipients regardless of HPV vaccination status.
The invention provides an oleogel dispersion and a preparation method thereof. The oil gel dispersion liquid consists of oil gel and a continuous phase solution, wherein the oil gel is prepared from grease, an oil phase thickener and an encapsulation object, and the continuous phase solution is prepared from an aqueous phase thickener, a humectant and a solvent. The oil gel is formed by encapsulating an easily oxidized encapsulate with a grease, oil phase thickener. The oil gel prevents the encapsulated substance from contacting with water, thereby isolating oxygen in the external environment and finally achieving the purpose of avoiding the oxidation of the active substance. After the oil gel is prepared and formed, a layer of positive charge is attached to the surface of the oil gel through the cationic surfactant, so that all the oil gel particles can repel each other, and the conditions of adhesion, cloudiness, floating, damage, swelling and the like are effectively avoided. The oil gel with positive charges on the surface can be independently and stably suspended in the continuous phase solution. The preparation method of the oil gel dispersion liquid can realize continuous production, and has high production efficiency, simple process and low cost. The oil gel dispersion liquid can be widely applied to the fields of cosmetics, foods, medicines, health care products and the like, and has wide application range.
This arm will receive a total of 10 mcg/kg of Fentanyl (Low Dose). First half-dose will be given at induction and second half -dose given before incision.
On entry to the anaesthetic room, children will be given an iPad (the intervention) with art, music and games to distract them. A nurse will help them engage with the iPad whilst the anaesthetists complete the anaesthetic. Once the child falls asleep, the iPad will be removed. This process is anticipated to last between 3 and 30 minutes depending on the time taken to anaesthetise the child.
OBJECTIVE: This study determined the association between acute changes in physical activity, temperature, and humidity and 24-hour subjective and objective hot flash experience.
METHODS: Data collection occurred during the cooler months of the year in Western Massachusetts (October-April). Women aged 45-55 across three menopause stages (n = 270) were instrumented with ambulatory monitors to continuously measure hot flashes, physical activity, temperature, and humidity for 24 hours. Objective hot flashes were assessed via sternal skin conductance, and subjective hot flashes were recorded by pressing an event marker and data logging. Physical activity was measured with wrist-worn accelerometers and used to define sleep and wake periods. Logistic multilevel modeling was used to examine the differences in physical activity, humidity, and temperature in the 10 minutes preceding a hot flash versus control windows when no hot flashes occurred. The odds of hot flashes were considered separately for objective and subjective hot flashes as well as for wake and sleep periods.
RESULTS: Data from 188 participants were included in the analyses. There was a significantly greater odds of a hot flash following acute increases in physical activity for objective waking hot flashes (odds ratio [OR], 1.31; 95% confidence interval [CI], 1.17-1.47; P < 0.001) and subjective waking hot flashes (OR, 1.16; 95% CI, 1.0-1.33; P = 0.03). Acute increases in the actigraphy signal were associated with significantly higher odds of having an objective (OR, 1.17; 95% CI, 1.03-1.35; P < 0.01) or subjective (OR, 1.72; 95% CI, 1.52-2.01; P < 0.001) sleeping hot flash. Increases in temperature were significantly related to the odds of subjective sleeping hot flashes only (OR, 1.38; 95% CI, 1.15-1.62; P < 0.001). There was no evidence for a relationship between humidity and odds of experiencing any hot flashes.
CONCLUSION: These results indicate that acute increases in physical activity increase the odds of hot flashes that are objectively measured and subjectively reported during waking and sleeping periods. Temperature increases were only related to subjectively reported nighttime hot flashes.
This research was conducted as a pre-test, post-test randomized controlled study to determine the effects of a Cognitive Behavioral Therapy (CBT)-based Family Counseling Program on anxiety and mindfulness levels in university students experiencing future anxiety. The study collected data from 20 students, divided equally between 10 participants in the intervention group and 10 in the control group. Data were gathered using a Personal Characteristics Form, the Future Anxiety Scale for University Students, and the Turkish version of the Mindfulness Awareness Scale for Adolescents and Adults.

The intervention group participated in an online CBT-based Family Counseling Program, which was conducted weekly for 8 weeks, each session lasting between 50-60 minutes. For the first 6 weeks, the sessions included only the students, while the last two weeks also involved family members' participation. No intervention was applied to the control group. Both groups were assessed with the aforementioned scales before the intervention and after its conclusion. This study aims to provide insights into the effectiveness of integrating family dynamics into therapeutic practices for reducing anxiety and enhancing mindfulness among students.
The StSST program is adapted from a 9-session weekly smoking cessation group program developed at the Outpatient Research Program of the Maryland Psychiatric Research Center and designed for people with schizophrenia. In this study, the StSST program meet twice per week for 3 months (24 sessions total). Participants complete a breath carbon monoxide test at the start of each group meeting. StSST groups provide education about smoking and support for quitting.
A process is disclosed for obtaining a C-polysaccharide cell wall antigen containing not more than about 10 % protein from Streptococcus pneumoniae bacteria. The antigen thus obtained is conjugated to a spacer molecule, and the free end of the latter is then conjugated to a chromatographic affinity column. The column is then utilized to purify raw antibodies to S. pneumonia e bacteria, thereby producing antigen-specific antibodies. A portion of such antibodies is conjugated to a labeling agent which displays a visible color change upon reaction of the antibodies with their antigenic binding partner and embedded in a first zone of an immunochromatographic assay device. Anoth er portion of such antibodies is bound to the reaction zone of the device which  has a view window. When a liquid sample, such as patient urine, cerebrospina l fluid or blood is applied to the first zone, the conjugate of antibodies and  labeling agent and the sample move along a flow strip of bibulous material t o the reaction zone wherein, if the sample contains S. pneumoniae or its cell wall antigen, a sandwich is formed among the labeled conjugate, the antigen and the bound antibodies and a color change is observed. The immunochromatographic assay thus performed is completed within about 15 minutes. This assay affords a basis for rapid and reliable diagnosis of various pathogenic states caused by S. pneumoniae including pneumonia, bronchitis, otitis media, sinusitis, meningitis, and secondary disease state s that commonly occur when primary pneumonic infection caused by this bacteriu m persists undiminished over a time period of 3-5 days.
The present invention relates to a method for preparing compound micron barley green milk tablets for reducing blood sugar and keeping beauty. Micron picolinic acid chromium powder, micron barley green powder, micron yam powder, micron tartary buckwheat flour, micron pearl powder and isomaltitol powder raw material carrying out high-technology airflow superfine grinding processing are added into various traditional milk power and combined and processed into the milk tablets. The milk tablets have the obvious function of reducing blood sugar and also have the effects of strengthening spleens, keeping beauty, tranquilizing, improving eyesight, allaying fatigue, enhancing immunity, etc. Diabetics can obtain scores of nutrient substances such as abundant protein, vitamins, mineral substances, active ferment, etc., and simultaneously, the milk tablets perform the health-care functions of beautifying faces, keeping beauty, strengthening spleen and reducing blood sugar because the raw materials such as picolinic acid chromium, etc. which are extolled as blood sugar-reducing factors are added. Therefore, the present invention is a favorable method for preparing the milk tablets for reducing blood sugar and keeping beauty, the milk tablets have Chinese characteristics, and the milk tablets are used for health care and lifetime prolonging and especially designed for middle-aged diabetics and old diabetics all over the world.
FIELD: medical industry. SUBSTANCE: present invention describes diethylammonium salt of N- methylamino-1- phenylmethanesulfonic acid of formula I:  . Said compound is prepared by reacting benzylidene methylamine with sulfur dioxide and diethylamine in ethyl alcohol in the presence of 5 mole % triethylbenzylammonium chloride followed by addition of water for 14-16 minutes at 40-50 C. Yield is 91.4+-0.5 %. Empirical formula is C 12 H 22 N 2 O 3 S•. The claimed compound has stable bactericidal and chlamydiostatic activities at concentration in solvent of 10-100 mg/ml directly in vitro and aerosol form at concentration of 1.5-15 mg/l in air. EFFECT: improved properties of the title compound. 2 cl, 5 tbl