anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Poststroke aphasia (PSA) recovery shows high variability across individuals and at different time points. Although diffusion biomarkers from the ventral and dorsal streams have demonstrated strong predictive power for language outcomes, it is still unclear how these biomarkers relate to the various stages of PSA recovery. In this study, we aim to compare diffusion metrics and language measures as predictors of language recovery in a longitudinal cohort of participants with PSA.
METHODS: Participants were recruited at a stroke unit at the emergency room, and underwent diffusion magnetic resonance imaging scanning and language assessment within 3 days (acute phase) after stroke, with behavioral follow-ups at subacute (10±3 days) and chronic phases (>6 months). We conducted regression analyses on language performance (cross-sectional), Δscores between all time points (acute-subacute, subacute-chronic, acute-chronic), and relative Δscores between all time points (Δscore/language baseline score), with acute diffusion metrics from language-related white matter tracts, lesion size, language baseline scores, and demographic data as predictors.
RESULTS: Thirty-nine participants presenting PSA were recruited, and 24 participants (mean age, 73 years; 8 women) completed the 3-time point assessment in total. The best prediction model of performance scores used axial diffusivity from the left arcuate fasciculus in both the subacute (R2=0.785) and chronic stages (R2=0.626). Moreover, the prediction of ∆scores depended on axial diffusivity from the left inferior frontal-occipital fasciculus in the subacute stage (R2=0.5) and depended additionally on axial diffusivity from the right inferior frontal-occipital fasciculus in the chronic stage (R2=0.68). The prediction of mediation analyses showed that the lesion load of the left arcuate fasciculus mediated the relationship between axial diffusivity from the left arcuate fasciculus and chronic language performance.
CONCLUSIONS: Language performance at subacute and chronic time points could be predicted by the integrity of the left arcuate fasciculus, whereas Δscores in the subacute and chronic phases depended on the left inferior frontal-occipital fasciculus, showing a dissociation of the white matter pathways about language outcomes. These results suggest a functional differentiation of the dual-stream components in PSA recovery.
Radiation-induced heart disease is associated with a significantly higher morbidity and mortality in cancer patients. The most frequent forms treated with chest radiation therapy are breast, lung, and esophageal cancers or lymphoma. The chances of developing radiation-induced heart disease increase with higher cumulative doses (\>30 Gray) in anterior or left sided irradiation, concomitant chemotherapy, presence of cardiovascular risk factors, and increased distance from time of irradiation. The estimated incidence of major cardiac events related to ischemic heart disease is 30% at 10 years post-treatment in female patients with radiotherapy post-breast cancer. The resulting epicardial artery stenosis, low grade inflammation , myocardial fibrosis, microvascular injury , alterations in autonomic balance, valve leaflets, and accelerated calcification can lead to significant alteration of all SE steps. A sample size of 507 patients is required and will be enrolled.
As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued. The syndrome can also develop, although much less frequently, after relatively brief treatment periods at low doses. This syndrome appears in all age groups. Although its prevalence appears to be highest among elderly patients, especially elderly women, it is impossible to rely upon prevalence estimates to predict at the inception of antipsychotic treatment which patients are likely to develop the syndrome. The symptoms are persistent and in some patients appear to be irreversible. The syndrome is characterized by rhythmical involuntary movements of the tongue, face, mouth or jaw (e.g., protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements). Sometimes these may be accompanied by involuntary movements of extremities. In rare instances, these involuntary movements of the extremities are the only manifestations of tardive

dyskinesia. A variant of tardive dyskinesia, tardive dystonia, has also been described.

There is no known effective treatment for tardive dyskinesia; antiparkinsonism agents do not alleviate the symptoms of this syndrome. It is suggested that all antipsychotic agents be discontinued if these symptoms appear. Should it be necessary to reinstitute treatment or increase the dosage of the agent or switch to a different antipsychotic agent, the syndrome may be masked.

It has been reported that fine vermicular movements of the tongue may be an early sign of the syndrome, and if the medication is stopped at that time, the syndrome may not develop.
The present invention relates to a parturient puerperium washing and protection bath paste, which is mainly prepared from tender catchweed bedstraw herb, ilex latifolia thunb, listeacubeba (lout.) pers, maple leaf, uncaria rhynchophylla (miq.) miq. ex havil, inula cappa dc, alchornea trewioides (benth.) muell. arg, sarcandra glabra (thunb.) nakai, wild rubus taiwanianus matsum, and rubus blinii levl. The parturient puerperium washing and protection bath paste has the body cleaning effect, can provide effects of wind-evil dispelling, coldness expelling, dampness removing, tendon relaxing and activating, blood circulation activating, blood stasis dissipating, qi circulation promoting, pain relieving, antibacterial, anti-inflammation, sweat releasing and toxin expelling on the weak body of the parturient, can provide effects of odor removing, fulsome air removing, lochia reducing, vagina contraction, abdomen contraction, damage vagina repairing, effective striae gravidarum reducing, rapid physical strength recovery, immunity enhancing, and prevention of various postpartum gynecological diseases, and can further provide functions of parturient sleep quality enhancing and mammary abscess production reducing, such that the baby can have the good and health rest.
BACKGROUND: Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. CRC deaths can be reduced with prevention and early diagnosis. Circulating tumor DNA-based liquid biopsies, are emerging tools for cancer detection. However, the tumor-signal-dependent nature of this approach results in low sensitivity in precancerous and early CRC stages. Here we propose the host immune response to the onset of cancer as an alternative approach for early detection of CRC.
METHODS: We perform whole transcriptome analysis of peripheral blood mononuclear cells (PBMCs) isolated from individuals with CRC, precancerous lesions or negative colonoscopy in two independent cohorts using next-generation sequencing.
RESULTS: We discover and validate novel early CRC RNA biomarkers. Taking into account, and adjusting for, the sensitivity of PBMCs transcriptomes to processing times, we report distinct transcriptomic changes in the periphery related to specific CRC stages. Activation of innate immunity is already detectable in the peripheral blood of individuals with pre-malignant advanced adenomas. This immune response is followed by signs of transient B-cell activation and sustained inhibition of T-cell responses along CRC progression, whereby at late stages, protumoral myeloid cells, wound healing and coagulation processes prevail. Moreover, some biomarkers show similar dysregulation in tumors and are implicated in known pathways of CRC pathophysiology.
CONCLUSIONS: The strong systemic immune modulation triggered during CRC progression leads to previously unnoticed alterations detectable in PBMCs, paving the way for the development of an early CRC screening blood test, incorporating 226 validated biomarkers identified through immunotranscriptomics.
BACKGROUND: Hypercytokinemia, the renin-angiotensin system, hypoxia, immune dysregulation, and vasculopathy with evidence of immune-related damage are implicated in brain morbidity in COVID-19 along with a wide variety of genomic and environmental influences. There is relatively little evidence of direct SARS-CoV-2 brain infection in COVID-19 patients.
METHODS: Brain histopathology of 36 consecutive autopsies of patients who were RT-PCR positive for SARS-CoV-2 was studied along with findings from contemporary and pre-pandemic historical control groups. Immunostaining for serum and blood cell proteins and for complement components was employed. Microcirculatory wall complement deposition in the COVID-19 cohort was compared to historical control cases. Comparisons also included other relevant clinicopathological and microcirculatory findings in the COVID-19 cohort and control groups.
RESULTS: The COVID-19 cohort and both the contemporary and historical control groups had the same rate of hypertension, diabetes mellitus, and obesity. The COVID-19 cohort had varying amounts of acute neutrophilic vasculitis with leukocytoclasia in the microcirculation of the brain in all cases. Prominent vascular neutrophilic transmural migration was found in several cases and 25 cases had acute perivasculitis. Paravascular microhemorrhages and petechial hemorrhages (small brain parenchymal hemorrhages) had a slight tendency to be more numerous in cohort cases that displayed less acute neutrophilic vasculitis. Tissue burden of acute neutrophilic vasculitis with leukocytoclasia was the same in control cases as a group, while it was significantly higher in COVID-19 cases. Both the tissue burden of acute neutrophilic vasculitis and the activation of complement components, including membrane attack complex, were significantly higher in microcirculatory channels in COVID-19 cohort brains than in historical controls.
CONCLUSIONS: Acute neutrophilic vasculitis with leukocytoclasia, acute perivasculitis, and associated paravascular blood extravasation into brain parenchyma constitute the first phase of an immune-related, acute small-vessel inflammatory condition often termed type 3 hypersensitivity vasculitis or leukocytoclastic vasculitis. There is a higher tissue burden of acute neutrophilic vasculitis and an increased level of activated complement components in microcirculatory walls in COVID-19 cases than in pre-pandemic control cases. These findings are consistent with a more extensive small-vessel immune-related vasculitis in COVID-19 cases than in control cases. The pathway(s) and mechanism for these findings are speculative.
Acanthamoeba keratitis (AK) is an ultra-rare potentially devastating ocular infection that occurs primarily in contact lens wearers. The estimated incidence in Europe varies between 1 and 3 cases/million people per year. AK is caused by a ubiquitous free-living protozoan that is present in air, soil, dust, fresh water, seawater, and bottled water. The amoebic organism exists both as dormant cysts and active trophozoites. The cysts are highly resilient and can withstand a wide variety of physical conditions and drugs which makes medical treatment of AK both difficult and protracted. If left untreated, the cure rate is low with most patients needing keratoplasty and some of them requiring enucleation. There is currently no approved pharmacological treatment for AK. Available treatment options are represented by off-label antiseptic products which are either imported or compounded, the most used being biguanides (polihexanide-PHMB- or chlorhexidine), given alone or in combination with a diamidine (propamidine or hexamidine). The actual reported medical cure rate with no surgery is approximately 60%; in addition almost 50% of patients have a poor outcome, defined as a poor visual acuity and/or necessity of ocular surgery. Polihexanide 0.8 mg/ml, an eye drops solution developed and manufactured by SIFI SpA (Italy), has the potential to become the first treatment approved for the treatment of AK. Its efficacy and safety were demonstrated in the pivotal clinical study 043/SI (EUDRACT no. 2016-001823-30; ClinicalTrials.gov: NCT03274895), in which the mean (95% IC) cure rate with no surgery was 84.8% (73.9-92.5) with a median (95% IC) time-to-cure of 146 (94-217) days. In addition, no major safety issues were observed during the trial. A positive opinion from the Committee for Medicinal Products for Human Use at EMA is expected in Q2/2024. Polihexanide 0.8 mg/ml has been made available in Italy by SIFI S.p.A. through a compassionate use program (CUP) since November 2022 (Compassionate use program, version 1.1-ITA-Aug 11, 2022). As of December 2023, the treatment with 0.8 mg/ml polihexanide was approved for 71 patients with AK. SIFI prepared this protocol to conduct a retrospective medical chart review of patients which already completed the treatment with 0.8 mg/ml polihexanide as part of the CUP. The expected number of evaluable patients is 40. According to the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP) this will be a Non-Interventional Study (as defined in the Directive 2001/20/EC) with secondary use of data. The protocol was prepared following the good practices report of the ISPE/ISPOR task force.

The expected contribution from this study will be to expand patient's exposure to polihexanide 0.8 mg/ml and provide further information on its effectiveness and safety when used in the clinical practice compared with the findings observed in the pivotal clinical trial.
The invention relates to a traditional Chinese medicine used for treating viral encephalitis. The traditional Chinese medicine is characterized in that the medicine is an oral preparation prepared from medicine materials of: 10-15g of honeysuckle flower, 8-10g of weeping forsythia fruit, 6-8g of golden thread, 8-10g of Chinese peony, 4-6g of mint, 4-6g of arctium fruit, 6-8g of sharpleaf gambirplant stem with hooks, 4-6g of acorus gramineus, 6-8g of thinleaf milkwort root, 8-10g of ginseng, 6-8g of tuckahoe, 6-8g of tree peony bark, and 4-6g of raw licorice root. For adults, one preparation is taken per day; for children, 1/2-1/3 preparations are taken per day; for babies, 1/3 preparations are taken per day, and the preparations are taken twice per day, once in the morning and once in the evening; for infants, 1/4 preparations are taken per day, and the preparations are fed 3-5 times per day. The traditional Chinese medicine provided by the invention is formulated according to treatment principles of heat clearing, dampness removing, detoxifying, wind subduing, and qi and blood regulating. The medicine provided by the invention is advantaged in simple preparation, low cost, fast effect, high curative rate, and no toxic or side effect. Clinically, treatments are carried out aiming at different symptoms.
Group A: Hyperbaric Oxygen Therapy (HBOT) and Exercise with HBOT sessions for 90 minutes, once daily, 5 times a week for 8 consecutive weeks. HBOT will be provided with 100% oxygen at 2.0 ATA. Patients will exercise in the multiplace hyperbaric chamber while receiving hyperbaric oxygen.
AIMS: Fractional excretion of urea nitrogen (FEUN), used to differentiate the cause of acute kidney injury, has emerged as a useful fluid index in patients with heart failure (HF). We hypothesized that FEUN could be useful in identifying worsening renal function (WRF) associated with poor outcomes in patients with acute HF (AHF).
METHODS AND RESULTS: Overall, 1103 patients with AHF (median age, 78 years; male proportion, 60%) were categorized into six groups according to the presence of WRF and FEUN values (low, ≤32.1%; medium, >32.1% and ≤38.0%; and high, >38.0%) at discharge. WRF was defined as an increase of ≥0.3 mg/dL in the serum creatinine level from admission to discharge. FEUN was calculated by the following formula: (urinary urea × serum creatinine) × 100/(serum urea × urinary creatinine). The cut-off values for low, medium, and high FEUN were based on a previous study. The primary outcome of this study was HF readmission after hospital discharge. During the 1 year follow-up, 170 HF readmissions occurred. Kaplan-Meier analysis revealed significantly higher HF readmission rates in patients with WRF than in those without WRF (log-rank test, P < 0.001). Additionally, among patients with WRF, HF readmission rates were lowest in those with medium FEUN values, followed by those with low FEUN values and those with high FEUN values. On multivariable analysis, the presence of WRF with low or high FEUN values was independently associated with increased HF readmission, as compared with the absence of WRF with medium FEUN values. Notably, no association was noted between WRF with medium FEUN values and HF readmission.
CONCLUSIONS: The prognostic impact of WRF was significantly mediated by the FEUN values and was associated with worse outcomes only when the FEUN values were either low or high. Our study suggests that FEUN can identify prognostically relevant WRF in patients with AHF.
To make a treatment plan suitable for a patient.SOLUTION: A treatment plan support device of an embodiment has an acquisition unit, a first estimation unit, a first generation unit, a second estimation unit, and a presentation unit. The acquisition unit acquires a treatment plan including patient information on a patient, first treatment for the patient, and second treatment for the patient performed after the first treatment. The first estimation unit estimates a first effect of treatment brought about by the first treatment based on the patient information. The second estimation unit estimates a second effect of treatment brought about by the second treatment based on the first effect of treatment. The first generation unit generates reference information on the treatment plan based on the second effect of treatment. The presentation unit presents the treatment plan and the reference information.SELECTED DRAWING: Figure 2
Cancer ranks second after cardiovascular diseases among the causes of death in the world and in our country and it is predicted that by 2030 this situation will change due to changing living and environmental conditions and cancer will take the first place. Breast cancer is the most common type of cancer among female cancers. Breast cancer is a type of cancer that can be prevented and treated if diagnosed early. For this reason, screening programs have been developed to prevent breast cancer and these screening programs include breast self-examination (BSE), clinical breast examination and mammography. These screening programs, which are also accepted in our country, include all women between the ages of 20-69. should be included. However, 11% of breast cancer cases are diagnosed at a distant stage. Disability for women, it affects their access to health services; people's perceptions of disability, inappropriate health services facilities and equipment, stereotypes and discrimination, economic inadequacy, negative treatment from staff, unequal allocation of time and money within the household for their care, limited health service coverage and lack of disability-related education, sensitization or recognition of women as a person in need of sexual and reproductive health care impede women's seeking, use and access to health care. However, every woman has the right to regular gynecological examinations and good care. In our study, the breast cancer awareness of visually impaired women and the effect of training based on the health belief model on their ability to perform breast self-examination will be evaluated. The population of the study consists of visually impaired women between the ages of 20-69. The sample of the study was calculated based on Cohen's effect size study.

Taking d (effect size) as 0.8, α= 0.05 and power as 0.95, the experimental group was determined as 42 and the control group as 42 people. G power 3.1 program was used in the calculations. Considering the problems that may occur during the research process, 45 in the experimental group and 45 in the control group, a total of 90 people constitute the sample of the study. As data collection tools; a questionnaire form including sociodemographic data created by the researchers, Champion's Health Belief Model Scale and KKMM Skill Checklist on Model will be used. The data will be analyzed with descriptive analyses in SPSS program and pre-test - post-test comparative analyses will be performed to determine the effectiveness of the intervention.
* The study was carried out at Faculty of Nursing Damanhour University Egypt. The Faculty of Nursing has nine different scientific nursing departments including pediatric nursing department. Pediatric nursing is one of the main courses was taught for the students enrolled in the third year in each term in the third scholastic year. Each term is consisting of 15 weeks. The clinical training (rotation) is given 12 hours /week.
* The present study subjects comprised of 150 students. The sample size was determined by using EPI Info 7 program using the following information: Population size = 500 (total no. of pediatric nursing students during the 2nd term of the academic year 2022 -2023), expected frequency =50%, acceptable error= 10%, confidence coefficient = 99%, which revealed a simple size = 125.
The present invention provides a delivery system for active and functional ingredients. In particular, the delivery systems of the present invention find particular application in the delivery of active and functional ingredients, such as medica-ments, pharmaceuticals, nutritional supplements, botanicals, cosmeceuticals etc.  Further, the invention relates to a delivery system for oral or topical administration of such active and functional ingredients.  The invention is a delivery system based on a particu-late gel precursor that acts both as the bodying agent,as well as the dispersing and suspending agent in the formulation. By modi-fying the level of precursor and process conditions, a broad range of product consistencies can be achieved ranging from thin liq-uid suspension to firm or semi solid gel. The precursor gel is a particulate linear chain fuctan gel. Inulin is a preferred fructan.
Sham-PBMT will be delivered in the same manner as indicated for the Active treatment process, but the devices will not be turned on. The participant will be asked to lay in a specialized full body light bed equipped with light-emitting diodes (LEDs) for a 20-minute session. Sham-PBMT Treatment will be provided 3 times a week for 3 weeks.
Cesarean sections are one of the most common surgeries performed in the United States; approximately 1 out of 3 births are completed by cesarean delivery. In 2014, 1,284,551 cesarean deliveries were performed. Unfortunately, even with this being a very common procedure some surgical topics have not been fully evaluated. One of these topics is the choice of suture for repair of the hysterotomy (uterine) incision. Several suture materials are available, yet only polygatactin-910 and catgut have been evaluated in a single study. In this study, only surgery complications were evaluated. Catgut was found to be associated with less risk of receiving a blood transfusion, otherwise no differences were found. One of the most common suture materials used at our institution is poliglecaprone 25, however no long term studies have been completed for this indication. In addition, no studies have evaluated the risk of uterine rupture with trial of labor after cesarean after using poliglecaprone 25 to repair the hysterotomy. This information could be very useful in counseling for patients. As the cesarean delivery rates continue to climb, information on appropriate technique for surgery are needed.