anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a health management system combined with a smart bed set. Different from a medical system, during the sleep time necessary in people's daily life, the system is provided to use a smart bed or pillow to unknowingly detect the accumulated data and compare and analyze the accumulated data for a long time without affecting the quality of life, so as to break through the limitations of time and space when people go to the hospital for examination and to assist in early detection of possible diseases thereby achieving the effect of health management. The system includes a physiological information detection module, a database, an analysis unit, and a display module, which are all connected to the smart bed set by signals. The physiological signals of the user during daily sleep can be detected and then analyzed by the analysis unit to be displayed on the display module, or accumulated and continuously stored in the database for comparative analysis, which can be used to find the timing of physiological abnormalities early. The database can be built on a cloud platform, a computer or a smart phone for users to perform personal health management or provide medical staff as a reference for medical purposes, which is extremely industrially usable and progressive. Moreover, the system further includes a smart bed set having a data processing module and a wired or wireless transmission module. The physiological information detection module is connected to the data processing module. The database has physiological data statistics. The analysis unit can read the information of the database and is connected to the wired or wireless transmission module. The display module is connected to the analysis unit by signals. The database and the analysis unit are application programs built in the external networking device and the display module is a display screen of the external networking device.
Utilizing intellectual property developed out of the University of Texas Health Science Center in Houston, Neo40 is a GMP certified, over the counter, all natural formulation that provides a system for generating NO in an endothelium-dependent and independent manner. The NEO40™ Daily™ product ingredients list and packaging was submitted to FDA Office of Compliance by Neogenis Labs, Inc. for use as a dietary supplement. It is made up of Beet root extract, hawthorne berry, Vitamin C, L-citrulline and sodium nitrite. The lozenges utilize natural product chemistry activated by the saliva to generate authentic NO gas in the oral cavity through the one-electron reduction of nitrite. This product's formulation was designed to be a quick dissolve that melts in the mouth within four to five minutes.
1. A method for the treatment of infertility in women, comprising administering a patient in need thereof FSH and/or a biologically-active analogue at an initial dose in the range of from 100 to 600 IU followed by a second dose at least 3 days later in the stimulation phase. 2. The method as claimed in claim 1, wherein the FSH and/or a biologically-active analogue thereof is for administration at a dose in the range of from 300 to 600 IU on every third day of the first 6 days of the stimulation phase. 3. The method as claimed in claim 2, wherein the dose is in the range of from 400 to 500 IU. 4. The method as claimed in claim 3, wherein the dose is in the range of from 430 to 470 IU. 5. The method as claimed in claim 3, wherein the dose is about 450 IU. 6. The method as claimed in any one of claims 2 to 5, wherein the medicament is for administration on days 1 and 4, days 2 and 5 or days 3 and 6 of the stimulation phase. 7. The method as claimed in claim 1, wherein the initial dose is in the range of from 100 to 500 IU. 8. The method as claimed in claim 7, wherein the initial dose is in the range of from 200 to 400 IU. 9. The method as claimed in claim 8, wherein the initial dose is about 300 IU. 10. The method as claimed in any one of claims 7 to 9, wherein the second dose is administered between three and six days after the initial dose. 11. The method as claimed in claim 10, wherein the second dose is administered four days after the initial dose. 12. The method as claimed in any one of claims 7 or 8, wherein the second dose is in the range of from 50 to 200 IU. 13. The method as claimed in claim 12, wherein the second dose is in the range of from 70 to 100 IU. 14. The method as claimed in claim 13, wherein the second dose is about 75 IU. 15. The method as claimed in any one of claims 7 to 14, wherein the second dose is repeated daily for 1 to 4 days, preferably 2 days. 16. The method as claimed in any one of claims 7 to 15, wherein the initial dose is administered on day 1, 2, 4 or preferably 3 of the stimulation phase. 17. The method as claimed in any preceding claim, wherein the FSH is recombinant FSH (r-FSH). 18. The method as claimed in any preceding claim, wherein the FSH is human FSH (hFSH).
The invention relates to a traditional Chinese medicine for controlling grease, preventing losing hair and accelerating the growth of hair. The traditional Chinese medicine includes angelica, rehmanniae praeparatum, dangshen, accessory piece, salvia miltiorrhiza, mucuna macrocarpa, yaoyanghe, Chinese date, liquorice, safflower, radix astragali, rehmannia glutinosa, Chinese dodder herb, Kutzulungshan, yerbadetajo herba ecliptae, polygonum, glossy privet fruit, mulberry, fructus corni, arborvitae top, sapindus mukorossi, euphorbia hirta, rhizoma gastrodiae, gingkgo, rhizoma ligustici wallichii, shallot and old ginger. The traditional Chinese medicines are weighed according to formulation proportion and mixed to be ground into powder, and then is evenly sprayed by wine to be capable of being all contacted with the wine. The wine is sprayed for once every two days, after being sprayed for three times, the spraying times can be reduced properly, and the process lasts for 1-4 weeks. Then, the mixture is mixed with purified water according to the proportion of 1:2.3-5, and is brewed for 3-6 months. After that, the mixture of water and the traditional Chinese medicine is stewed at the high temperature over 100 DEG C; when being boiled, the mixture is filtered to be mixed with water or other liquid shampoos for dilution, finally, the obtained product can be used. The traditional Chinese medicine has the advantages of remarkable effects, no toxicity and side effects and being good and cheap.
This arm will maintain standard of care for dry AMD, which is observation. During the 24 month study, subjects assigned to this arm will have 4 follow-up exams after the initial enrollment exam, at 6 month intervals.
PURPOSE:The titled substance containing an adrenochrome derivative or salt thereof as an active ingredient. CONSTITUTION:An activity enhancing substance inducer for blood stem cell colony-stimulating factor (CSF) obtained by containing a compound expressed by the formula (A is NH, O or S) or salt thereof, e.g. 1-methyl-5- guanylhydrazone-6-oxo-2,3,5,6-tetrahydroindole, etc., as an active ingredient. Oral agents, e.g. tablet, capsule, granule, powder, liquid formulation, etc., parenteral agent, e.g. subcutaneous, intramuscular, intravenous injection, etc., may be cited as the dosage form thereof. The compound expressed by the formula will not individually enhance the activity of the CSF, but is capable of inducing a substance for enhancing the activity of the CSF. A CSF inducer, e.g. a lithium compound, etc., is preferably administered to living bodies as a method for providing the CSF therein. The dose thereof is 150-450mg/adult/ day for oral administration and 10-100mg/adult/day for injection.
A system for monitoring medical activity of a patient comprises having a patient-held medical activity input device 22 (e.g. mobile telephone) into which patient specific data associated with the medical activity is input (e.g. administration of a drug(s), measurement of a physical metric such as blood pressure, blood sugar reading), and stored in a patient record, where the patient record is monitored to determine whether a significant event occurs, and an alert is generated in response to the detection of a significant event such as failure to take medicine. The alert may be sent directly to a doctor or other medical professional. A patient specific container (Figs 3-8) may be provided to house the medical activity input device. The patient specific container may be a patient bag adapted to hold patient necessities. The system may also include a patient identity device containing patient display information. Embodiments of the invention are particularly applicable to the remote monitoring of the medical activity of a patient following a care plan for a chronic illness. One application of the invention is the monitoring of Chronic Obstructive Pulmonary disease (COPD).
Traumatic optic neuropathy (TON) is a devastating condition that can occur after blunt or penetrating trauma to the head, leading to visual impairment or blindness. Despite these debilitating effects, no clinically available therapeutic targets neuroprotection or promotes axon regeneration in this or any optic neuropathy. Limited data in large-animal models are a major obstacle to advancing treatments toward clinical therapeutics. To address this issue, we refined a surgical model of TON in Yucatan minipigs. First, we validated the model by demonstrating visual impairment by flash visual-evoked potential and retinal ganglion cell degeneration and death. Next, we developed and optimized a delivery method and nontoxic dosing of intravitreal brain-derived neurotrophic factor (BDNF) and cAMP. Finally, we showed that intravitreal injection of BDNF and cAMP rescued visual function and protected against retinal ganglion cell death and optic nerve axon degeneration. Together these data in a preclinical large-animal model advance our understanding of and ability to model TON and further identify and develop candidate clinical therapeutics.
FIELD: medicine, particularly, complex methods of treatment and sanitation of organisms. SUBSTANCE: preliminarily, reasons for patient obesity and motives for undergoing of psychotherapy for reducing of excessive body weight are found out. On the basis of this information, individual psychological settings are elaborated for performance of psychotherapy and autogenic training. 3-10 seances of psychotherapy, 30 min each, are conducted. In this case, suggestions are effected in state of awake and in meditation. During seance of psychotherapy, passing circular motions by hand are executed in region of patient's brain and spinal cord. Motions are begun in region of head and finished by circular motions round each vertebra from top down over vertebra column. Simultaneously patient is suggested that activation of immunity system takes place and self-regulation is recovered. Patient is weighed every day, and if initial weight is reduced by 7-10%, low-caloric diet is prescribed for next 25-35 days, and drugs of vegetable origin are administered to improve metabolic processes. Myostimulation is performed and physical exercises on training equipment are made, at least, thrice a week, each lasting 30 min. EFFECT: higher efficiency of stable reduction of body excessive weight. 3 cl
The invention relates to a pharmaceutical composition for prevention and treatment of osteoporosis, and its preparation. The composition includes Cuscuta sinensis lam., or Fructus cnidii and Cuscuta sinensis lam., its active components contain high level coumarin and flavone after purification. The pharmaceutical composition made from Fructus cnidii and Cuscuta sinensis lam. Could improve mineral density of bone and increase content of calcium and phosphor in calcium distinctly. Otherwise, it can also reduce the oral toxicity of Fructus cnidii. The pharmaceutical composition consisted of only cuscuta sinensis lam is also effective. Further, the pharmaceutical composition described above could combine with calcium material and/or Vitamin D3 to reinforce the effect.
Patients with RAS gene mutations undergo iodine I-124 PET/CT on day 5 of week 1. Beginning day 6, patients receive trametinib PO daily for 4 weeks in the absence of disease progression or unacceptable toxicity. Patients undergo second iodine I-124 PET/CT on week 5. If I-124 PET/CT shows enough iodine absorption, patients may receive iodine I-131 PO and continue receiving trametinib for another 2 days. If I-124 shows that the thyroid is not absorbing iodine, patients have the option to be assigned to Cohort C.
###  2.1.1 MRI of the CNS

In adults and in pediatric patients over 2 years of age, the recommended dose of MultiHance for MRI of the CNS is 0.2 mL/kg (0.1 mmol/kg) administered as a rapid bolus intravenous injection. In pediatric patients below 2 years of age, the recommended dosage range is 0.1 to 0.2 mL/kg administered as a rapid bolus intravenous injection. To ensure complete injection of the contrast medium, follow the injection with a saline flush of at least 5 mL. Imaging of the CNS can be performed starting immediately after the bolus injection of MultiHance.

###  2.1.2 MRA of Renal and Aorto-ilio-femoral Vessels

For MRA examination, the recommended dose is 0.2 mL/kg (0.1 mmol/kg) administered as a rapid bolus intravenous injection followed by at least 20 mL saline flush either manually or using an automatic injector system. Start imaging immediately after the administration of MultiHance, with scan delay calculated by test bolus or automatic bolus detection technique. If an automatic contrast detection pulse sequence is not used for bolus timing, then a test bolus injection of 1-2 mL of MultiHance should be used to calculate the appropriate scan delay.
Proximal femoral fractures are frequent and complex injuries requiring prompt and targeted care. Numerous treatment strategies have been described, some of which have been assessed and clinically implemented clinically. The aim of surgical is always the restoration of a pain-free and stable extremity. Mostly elderly patients are affected and treatment is associated with high postoperative complications and mortality rates. With increasing numbers of patients, the topic is of great medical and economic relevance. In this work, the choice of implants for the osteosynthesis of proximal femoral fractures - as depending on the fracture type - will be examined, as based on a review of current literature. Standard care includes cannulated screws, sliding hips screws and cephalomedullary nails. In addition, the influence of implant positioning, fracture reduction and additional measures such as cement augmentation are evaluated and discussed. Careful fracture reduction and the quality of implant positioning are paramount in order to avoid complications.
Patients randomised into this arm will be orally administered with 200mg AK0529 q.d. for five days.
The control group will be exposed to 2D PC equivalent versions of the same multimedia experiences but on their PC screen (without the Virtual Reality headset use). These will be functionally similar to the VR experiences.
BACKGROUND: Subcutaneous emphysema is a condition where air becomes trapped under the skin, typically resulting from surgery or skin trauma. It is mostly localized and its occurrence in blood donors is exceedingly rare. Phlebotomy poses minimal risk of subcutaneous emphysema, but procedural errors may lead to such complications.
STUDY DESIGN AND METHOD: This is a case report of 29-year-old repeat blood donor who experienced subcutaneous emphysema following blood donation. The donor was vigorously squeezing sponge ball during donation resulting in displacement of the needle which required readjustment. Post-donation, the donor reported a crackling sensation and mild swelling near phlebotomy site. Non-contrast computed tomography (NCCT) scans confirmed subcutaneous emphysema, attributing its development to air trapping in subcutaneous plane due to ball valve mechanism.
RESULTS: Computed tomography (CT) imaging revealed subcutaneous emphysematous changes in the right cubital region and no evidence of hematoma. The swelling spontaneously subsided in 10-12 days without any intervention. The case underscores the importance of differentiating subcutaneous emphysema from common complications like hematoma.
DISCUSSION: Subcutaneous emphysema in blood donors is exceptionally rare but should be managed with clear communication. Donors should be reassured that the condition, although rare, is benign and self-resolving. Healthcare providers should be equipped to handle such rare complications, offering appropriate care and documenting incidents for future prevention.
The present disclosure provides compositions for enhanced delivery of therapeutic agents. Drug delivery vehicle compositions may include a modified polysaccharide (e.g. chitosan) having at least one secondary amine or at least one tertiary amine and a therapeutic agent such as a therapeutic nucleic acid and/or a therapeutic anionic agent. Various additional modifications of a modified polysaccharide of the disclosure are also described. Exemplary therapeutic agents may include but are not limited to nucleic acids, polynucleotides, siRNA and/or pDNA. Compositions of the disclosure may be formulated as nanoparticles and may provide one or more advantages including efficient transfection, bio-delivery, availability, buffering ability, serum stability. Methods for synthesizing the drug delivery compositions are also set forth. The disclosure also provides methods for delivering/administering therapeutic agents using the drug delivery compositions of the disclosure to a patient in need thereof. Therapeutic methods are also provided.
Participants received 2 milligram (mg) of Baricitinib tablet orally once a day for 12 weeks. Cohort A is not reported due to protection of personal identifiable information based on enrollment futility.
PURPOSE:To display retrieved check data in an optimum form by showing the attributes of the check data in a matrix of checking time points and checking items and varying a display form in response to the designated position of said matrix. CONSTITUTION:When a doctor gives an instruction for start of a health history control program, a list of the check results are displayed in a matrix form on a screen 1-2 of a CRT. Then the doctor puts a cursor on a column 5-1, for example, and clicks the button of a pointing device. The same operations are given to a column 5-2. Thus the history of the blood sugar values is displayed. Furthermore the doctor clicks the columns 5-3 and 5-4 out of the checking date columns to display a table of check values of the blood pressure, the liver function and the blood lipid of 1986. When the area of a medical examination item is clicked, the medical examination data on the click designated check items are displayed in a graph.
Possible regional techniques for breast surgery include selective intercostal nerve blockade, thoracic paravertebral blockade, thoracic epidural, intrapleural, local wound infiltration. Each of these techniques has advantages and disadvantages. In general, local or wound infiltration is safe but limited in terms of duration of action, depending on the local anesthetic (LA) used. More invasive techniques such as selective intercostal nerve blocks and thoracic paravertebral blockade may be complicated by pneumothorax or transient Horner's syndrome These techniques are also may be associated with higher risk of local anesthetic toxicity. Besides the neurological side-effects associated with thoracic epidural and paravertebral blocks such as post-sympathectomy hypotension and bradycardia, total spinal block, paraplegia, epidural hematoma, unpredictable spread, intravascular injection also requires special skill precluding their routine use in the setting of day-case surgery. With the use of ultrasound (US) devices in anesthetic practice, newer regional techniques based on detailed knowledge of innervations of the breast are developed as the pectoral nerve (Pecs) block I and II.The breast innervations briefly include lateral and medial pectoral nerves that arise from the brachial plexus innervating the pectoral muscles.The anterior divisions of the thoracic intercostal nerves from T2 to T6. They give off lateral and anterior branches. The Lateral branches pierce the external intercostalis and the serratus anterior muscles at the mid-axillary line to give off anterior and posterior terminal cutaneous branches. The lateral cutaneous branch of the second intercostal nerve does not divide and it is called the intercostobrachial nerve.The Anterior branches pierce the internal intercostalis muscle, the intercostal membranes, and pectoralis major to supply the breast in its medial aspect.The long thoracic nerve passes on the serratus anterior muscle supplying it. The thoracodorsal nerve innervates the latissimus dorsi muscle.
OBJECTIVES: Understanding who uses internet-based sexually transmitted and blood-borne infection (STBBI) services can inform programme implementation, particularly among those most impacted by STBBIs, including gender and sexual minority (GSM) men. GetCheckedOnline, an internet-based STBBI testing service in British Columbia, Canada, launched in 2014. Our objectives were to assess reach, identify factors associated with use of GetCheckedOnline 5 years into implementation and describe reasons for using and not using GetCheckedOnline among GSM men.
METHODS: The Sex Now 2019 Survey was an online, cross-sectional survey of GSM men in Canada administered from November 2019 to February 2020. Participants were asked a subset of questions related to use of GetCheckedOnline. Multivariable binary logistic regression modelling was used to estimate associations between correlates and use of GetCheckedOnline.
RESULTS: Of 431 British Columbia (BC) participants aware of GetCheckedOnline, 27.6% had tested using the service. Lower odds of having used GetCheckedOnline were found among participants with non-white race/ethnicity (adjusted OR (aOR)=0.41 (95% CI 0.21 to 0.74)) and those living with HIV (aOR=0.23 (95% CI 0.05 to 0.76)). Those who usually tested at a walk-in clinic, relative to a sexual health clinic, had greater odds of using GetCheckedOnline (aOR=3.91 (95% CI 1.36 to 11.61)). The most commonly reported reason for using and not using GetCheckedOnline was convenience (78%) and only accessing the website to see how the service worked (48%), respectively.
CONCLUSION: Over a quarter of GSM men in BC aware of GetCheckedOnline had used it. Findings demonstrate the importance of social/structural factors related to use of GetCheckedOnline. Service promotion strategies could highlight its convenience and privacy benefits to enhance uptake.
Nitrofuran derivatives of the general formula (I). where R = hydrogen, methyl or hydroxymethyl. The compounds are antibacterial agents, having activity against a large number of gram negative and gram positive organisms. 147 g. N-methylaminoacetaldehyde diethylacetate was added to a solution of 115 g. acetone semicarbazone in 600 cc ethoxyethanol and the solution was refluxed for 6 hr. The solution was concentrated under reduced pressure and the residue diluted with ether. The precipitate formed was filtered off and washed with ether. The combined ether solution was concentrated under vacuum and 500 cc 10% sulphuric acid added to the residue. This solution was warmed on a steam bath and 113 g. 5-nitrofurfural dissolved in alcohol was added to the mixture which was then heated for 1 hr. on a steam bath. After cooling, the precipitate was filtered off, washed with water and dried to give 51 g. product, which was recrystallised from nitromethane to give pure 1-methyl-3-((5-nitrofurfurylidene)-amino) -4-imidazolinone-2. m.p. 238-240 deg.C.