anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Neuroelectrophysiological studies on various types of meditative breathing revealed its association with either a relaxing (i.e., enhanced alpha asymmetry) or an attentive state (i.e., enhanced intra- and inter-hemispheric theta coherence). The present study aimed to utilize these well-known neuroelectrophysiological techniques to investigate the relatively less studied Shaolin Dan Tian Breathing (DTB) technique. This technique consists of two components -- Passive DTB and Active DTB, and is considered not only as a relaxation exercise but also a form of Qigong. Based upon some pilot neuroimaging data and clinical observation, it was hypothesized that after familiarizing with the method, practicing DTB can induce both relaxing and attentive states. Twenty-two adults received training on the DTB (experimental group) for one month. They were instructed to practice the technique daily, and at each practice, until they felt warm and/or relaxed. Twenty age-, gender- and education-matched adults receiving conventional progressive muscle relaxation training were recruited as control. All participation was voluntary. Quantitative EEG and bio-physiological data were collected at baseline and post training. Eyes-closed resting EEG data before and immediately after each type of breathing were obtained individually at two time points.
This study will be a two-arm, assessor-blind, randomized controlled trial enrolling approximately 300 middle and high school students who have recently violated a school substance use policy. Participants will be followed over a one-year period. Participants will be randomly assigned to either four-weeks of iDECIDE or a waitlist control group. Participants assigned to receive iDECIDE will receive a drug education curriculum developed to provide behavioral support and psychoeducation via videoconference or in-person visits. The purpose of iDECIDE is to provide students with the knowledge and skills they need to make healthy decisions regarding substance use. Participants in the waitlist control group will undergo symptom and substance use monitoring only, until completion of the one-month follow-up visit at which point they will be offered the opportunity to enroll in the iDECIDE curriculum, if desired. Data collection will occur during nine visits over the span of approximately one year, including one randomization baseline visit, four weekly visits during the intervention phase of the study during which time participants will participate in either iDECIDE or monitoring, and then four follow-up visits. The follow-up visits will occur at approximately one week, one month, six months, and one year following the end-of-intervention. Participants in both arms will complete questionnaires and assessments conducted by raters blinded to study arm assignment. Primary outcomes (knowledge of drug effects, knowledge of brain development and neurobiology of addiction, readiness to quit, perceptions of harm, and frequency of substance use) will be assessed at visit 1 (baseline), visit 5 (end-of-intervention), visit 6 (one week follow-up), and visit 7 (one month follow-up). Participants will be compensated for session attendance and provision of urine samples.
A fractionable polydisperse stable double oil-in-water emulsion, having 50 to 95 wt. % relative to the total weight of the double emulsion, droplets of an invert monodisperse emulsion Ei dispersed in a continuous aqueous phase. The continuous aqueous phase includes a polysaccharide thickening agent in a proportion of 1 to 10 wt. % relative to the total weight of the continuous aqueous phase, a water-soluble ethylene oxide and propylene oxide block copolymer as surfactant, and an osmotic pressure balancing agent. The emulsion Ei has a viscosity not higher than the viscosity of the continuous aqueous phase and has 50 to 95 wt. %, relative to the total weight of Ei, droplets of an internal aqueous phase dispersed in an oily phase. The internal aqueous phase includes an active hydrophilic substance and the oily phase includes poly glycerol polyricinoleate as surfactant.
The sham rTMS protocol is performed by a sham coil. The sham rTMS protocol is a 15-minute 10Hz stimulation, 10 seconds on, 20 seconds off, at 90% RMT, for a total of 3000 pulses. The target is the primary motor cortex.
Pulmonary veno-occlusive disease (PVOD) is a rare but severe form of pulmonary hypertension characterized by the obstruction of pulmonary arteries and veins, causing increased pulmonary artery pressure and leading to right ventricular (RV) heart failure. PVOD is often resistant to conventional pulmonary arterial hypertension (PAH) treatments and has a poor prognosis, with a median survival time of 2-3 years after diagnosis. We previously showed that the administration of a chemotherapy agent mitomycin C (MMC) in rats mediates PVOD through the activation of the eukaryotic initiation factor 2 (eIF2) kinase protein kinase R (PKR) and the integrated stress response (ISR), resulting in the impairment of vascular endothelial junctional structure and barrier function. Here, we demonstrate that aged rats over 1 year exhibit more severe vascular remodeling and RV hypertrophy than young adult rats following MMC treatment. This is attributed to an age-associated elevation of basal ISR activity and depletion of protein phosphatase 1, leading to prolonged eIF2 phosphorylation and sustained ISR activation. Pharmacological blockade of PKR or ISR mitigates PVOD phenotypes in both age groups, suggesting that targeting the PKR/ISR axis could be a potential therapeutic strategy for PVOD.
BACKGROUND: For gastric cancer with total gastrectomy, the usual laparoscopic surgical approaches are totally laparoscopic total gastrectomy (TLTG) and laparoscopic-assisted total gastrectomy (LATG). Due to its difficult anastomotic technique, the adoption of TLTG is limited. Therefore, surgeons prefer using LATG, which also led to TLTG being somewhat overlooked, so there is no clear conclusion today as to which surgical procedure is more favorable to the patient's recovery. This article aimed to compare the safety and short-term outcomes of the two surgical approaches.
MATERIALS AND METHODS: Studies comparing TLTG and LATG, published up to December 2022, were searched in PubMed, Web of Science, and Embase databases. The study outcomes, including operative time, blood loss, anastomosis time, number of retrieved lymph nodes, proximal and distal resection margins, time to first fluid and soft diet, hospitalization duration, time to first flatus, and postsurgical and anastomotic complications, were compared between these two different surgical procedures. Statistics were analyzed with RevMan 5.4 and Stata 13.1.
RESULTS: Fifteen publications were included in this study. The total sample included 3023 cases. The meta-analysis revealed no significant difference in overall postoperative complications between the two surgical approaches ( P >0.05). Compared with LATG, TLTG led to reduced intraoperative blood loss ( P <0.0001), an increased number of lymphatic node dissections ( P <0.0001), and decreased hospitalization duration ( P =0.002). However, operative time, anastomosis time, pulmonary infection, resection margins, time to first fluid and soft diet, time to first flatus and anastomosis-related complications were no significant difference between TLTG and LATG groups ( P >0.05).
CONCLUSION: TLTG did not lead to an increase in overall postoperative complications, which is a reliable surgical approach for treatment of gastric cancer. Moreover, it may reduce harm to patients and enable them to obtain better surgical outcomes.
Psoralens are used orally or locally for photochemotherapy. On oral use, there is observed to be a saturable first-pass effect, i.e. a considerable proportion is therapeutically inactive. 5-Methoxypsoralen has a large therapeutic index but has less activity than 8-MOP which has only a relatively low therapeutic index. The invention comprises a combination of 5-MOP which is released without delay and 8-MOP which is likewise rapidly released but after a certain time delay. This combination has the following advantages:   1. The first-pass effect is saturated by 5-MOP which has a large therapeutic index. The 8-MOP is released later and is therefore efficiently absorbed and displays a large and reproducible effect. 2. An adequate therapeutic effect is therefore achieved with a considerably lower dose of light.
PURPOSE:To obtain an adhesive tape effectively emitting electron and giving curing effect to human body by adhering a large number of aluminum powder having excellent characteristics such as harmless to human body and readily operable on the surface of a tape. CONSTITUTION:The aimed adhesive tape for curing is obtained by adhering a large number of aluminum powder 1 on the surface 2 of an adhesive tape. Said adhesive tape adhered with aluminum is stuck on the surface of diseased skin and electrons are emitted to strongly charge the surface of skin with negative electricity. On the contrary, inside of the skin is strongly charged with positive electricity by dielectric polarization. Said positive electricity reduces extraordinarily increased electronic energy and inside of the skin is gradually inclined to positive electricity, then bad condition of human body is canceled. Aluminum is advantageous as effectively emits electron. Therefore, aluminum is adhered on whole surface of a tape to effectively emits electron.
Subjects were randomized into valsartan or sacubitril/valsartan arms in a 1:1 ratio. Regardless of the treatment arm a subject is in, the study drug was up-titrated to the highest tolerated dose level during the scheduled study visits. The different strengths of the two study drugs were not identical in appearance so the possible dose modification(s) during the treatment period could not be performed in a blinded manner. Subjects started on valsartan 80 mg BID or sacubitril/valsartan 100 mg BID dose and there was only one scheduled up-titration visit after the randomization. Exception for this were the subjects that were on valsartan 160 mg BID dose during the run-in phase. These subjects were randomized directly to valsartan 160 mg BID or sacubitril/valsartan 100 mg BID. Subjects that were randomized to valsartan arm had similar visit after which they continued on the same dose. For subjects that were randomized from valsartan 160 mg BID to sacubitril/valsartan 100 mg BID the dose was up-titrated to 200 mg BID if clinically possible.

The total duration for each patient was planned to be about 14 weeks but could be longer if required for scheduling purposes . The longest participation, from signing of ICF until end of study, was 26 weeks.
The invention provides foot soaking powder for regulating yang-deficiency constitution and a preparation method thereof. The foot soaking powder is prepared from the following raw materials in parts by weight: 1-200 parts of auckiandialappa Decne., 1-100 parts of crataegus pinnatifida, 1-100 parts of atractylodes lancea (Thunb.) DC., 1-100 parts of homalomena occulta (Lour.) Schott, 1-300 parts of zingiber officinale Rosc., 1-100 parts of epimedium davidii Franch, 1-150 parts of leguminosae, 1-150 parts of polygonatum sibiricum Red., 1-100 parts of spatholobus suberectus Dunn, 1-100 parts of pinellia ternata (Thunb.) Breit. and 1-100 parts of root of Chinese Thorowax. The preparation method comprises the steps of cleaning all the raw materials, draining, drying, mixing, crushing, then, sterilizing and packaging. According to the foot soaking powder, effective ingredients are conducted to corresponding regions of a human body through foot meridians, can play roles in blood circulation enhancing, qi and blood warming, middle qi regulating, qi tonifying, yang strengthening and cold-dampness dispelling, and have obvious effects on rehabilitation of yang-deficiency diseases, such as mental fatigue, obesity, puffiness, saccharated and watery excrement, cold hands and feet, cardiovascular diseases and the like.
A cosmetic auxiliary patch material comprising a layer structure having a base material layer provided on its one major surface with an adhesive layer. (1): The base material layer is a polyurethane elastomer layer of 0Â°C or below glass transition temperature. (2): The adhesive layer is an acrylic adhesive layer of copolymer containing 70 wt.% or more of units of at least one monomer selected from the group consisting of C8-C12 alkyl-having alkyl acrylates and alkyl methacrylates. (3): The thickness of the base material layer is in the range of 1 to 10 Î¼m. The thickness of the adhesive layer is in the range of 1 to 15 Î¼m. The total thickness of these layers is in the range of 2 to 20 Î¼m.
BACKGROUND: Recent studies have demonstrated that very high high-density lipoprotein cholesterol (HDL-C) level was paradoxically linked with higher risk of cardiovascular mortality, all-cause mortality, and several age-related diseases. However, whether very high HDL-C level is associated with a higher risk of sarcopenia in older adults remains unclear. We aimed to investigate the association between HDL-C level and the risk of developing sarcopenia and low grip strength over time in older adults.
METHODS: Participants were from the ongoing China Health and Retirement Longitudinal Study (CHARLS), which includes a nationally representative sample of adults aged ≥45 years and was performed from 2011 to 2020 with follow-ups every two to three years. The current study included 4031 participants aged ≥60 years. Muscle health-related data were collected in waves 2011, 2013, and 2015. Based on HDL-C level at baseline, participants were categorized into five groups: <35 mg/dl, 35-40 mg/dl, 40-60 mg/dl, 60-70 mg/dl and >70 mg/dl. The main outcomes were incident sarcopenia and incident low grip strength over follow-up. Low grip strength and sarcopenia were defined according to the 2019 Consensus by the Asian Working Group for Sarcopenia. Cox proportional-hazard regression was performed to investigate the association between HDL-C level and the risk of developing sarcopenia and low grip strength in older adults.
RESULTS: The mean age of study sample was 67.3 (SD 6.1) years, and 49.6% were male. During an average 3.7-year follow-up, 409 (10.1%) participants developed sarcopenia and 771 (21.1%) developed low grip strength. Non-linear association was observed between HDL-C level and the hazard of developing sarcopenia and low grip strength. The multivariable model showed that compared to the reference group (40-60 mg/dl), older adults with very high HDL-C level (>70 mg/dl) had a significantly higher risk of developing sarcopenia (HR 1.69, 95% CI 1.28-2.23) and low grip strength (HR 1.23 95% CI 1.00-1.51). Stratified analyses by sex revealed similar association.
CONCLUSIONS: We present the first longitudinal evidence that very high HDL-C level was associated with a significantly higher risk of muscle strength decline and developing sarcopenia in older adults. It is essential to monitor the muscle health of older adults with very high HDL-C level in clinical practice.
The present invention relates to a method for simply preparing a graphene dispersion solution by decomposing the graphite in an aqueous DNA solution with ultrasonic waves. A commercial dsDNA which is not chemically modified is used as a stabilizer for the graphite peeling operation. High-energy sound waves are used to divide the dsDNA to two ssDNA. The UV-Vis spectrum study shows that the nucleobases are maintained. A graphene sheet produced in a centrifugation process and seen through an atomic force microscope (AFM) is checked to have a small side surface value. The defects of the grapheme sheet formed by the ultrasonic waves are checked by using the Raman spectrum to be concentrated on the edges and are relatively rare on the center. The graphene nanosheet according to the present invention is very stable in a wide pH range having high negative zeta potential. The present invention also is confirmed to have anti-cancer activities in vitro toxicity studies. The graphene dispersion solution is confirmed to block the cancer cell metastasis in zebrafish embryos in vivo studies. Also, the negatively charged graphene sheet can be used as a platform to attract the gold nanoparticles having a positive surface charge.
OBJECTIVE: Inflammaging and immunosenescence are characteristics of senescent immune system alterations. This review provides insights into inflammaging and immunosenescence in periodontitis and focuses on the innerlink of inflammaging and immunosenescence in alveolar bone turnover from a perspective of cell-cell interaction.
METHODS: This review is conducted by a narrative approach to discuss the effect of inflammaging and immunosenescence in aging-related alveolar bone loss. A comprehensive literature research in PubMed and Google was applied to identify reports in English.
RESULTS: Inflammaging is concerned with abnormal M1 polarization and increasing circulating inflammatory cytokines, while immunosenescence involves reduced infection and vaccine responses, depressed antimicrobial function, and infiltration of aged B cells and memory T cells. TLR-mediated inflammaging and altered adaptive immunity significantly affect alveolar bone turnover and aggravate aging-related alveolar bone loss. Besides, energy consumption also plays a vital role in aged immune and skeletal system of periodontitis.
CONCLUSIONS: Senescent immune system exerts a significant function in aging-related alveolar bone loss. Inflammaging and immunosenescence interact functionally and mechanistically, which affects alveolar bone turnover. Therefore, further clinical treatment strategies targeting alveolar bone loss could be based on the specific molecular mechanism connecting inflammaging, immunosenescence, and alveolar bone turnover.
The invention comprises a tablet of a water-soluble salt of dextran sulphate coated uniformly with an enteric coating material which is insoluble in a simulated gastric fluid having a pH below 3.0 but dissolves or disintegrates in a simulated intestinal fluid having a pH ranging between 5.0 and 8.0.  The coating may be 0.05 to 1.0 mm. thick and is preferably followed by a further coating of acetoglyceride (an acetylated aliphatic glyceride wherein the carbon atoms of the fatty acid are 12 to 20) and a wax such as beeswax, carnauba wax, vegetable wax or synthetic wax.  Typical coating materials are sodium, potassium and ammonium salts of alginic acid; sodium potassium and ammonium salts of cellulose acetate phthalate; sodium, potassium and ammonium salts of cellulose acetate maleate; sodium, potassium and ammonium salts of polyvinyl alcohol phthalate; and sodium, potassium and ammonium salts of polyvinyl alcohol maleate; cellulose acetate phthalate, cellulose acetate maleate, polyvinyl alcohol phthalate, and polyvinyl alcohol maleate.  The dextran sulphate e.g. sodium or potassium salt, is mixed with a diluent such as starch and compressed or moulded to form a tablet. The tablet is coated with an adhesive e.g. aqueous gelatin and the enteric coating then applied.  The operation may be repeated to give the desired coating.  To assist dispersion of the dextran sulphate in the intestine and to promote absorption from the intestine the dextran sulphate salt may be mixed with isopropyl myristate and the stearic acid ester of a polyoxyethylene prior to granulation and compression into tablets.  The tablets of the invention are effective in the treatment of hyperlipemia.
OBJECTIVE: To analyze the effect of holistic nursing intervention on the nursing quality and satisfaction of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI).
METHODS: This is a retrospective study. 148 AMI patients admitted to the Department of Cardiovascular Medicine in our hospital were divided into a conventional group and an experimental group according to different nursing methods, with 74 patients in each group. Patients in the routine group were given routine nursing care, while those in the experimental group were given holistic nursing interventions. The nursing quality, the incidence of complications and nursing satisfaction were compared between the two groups.
RESULTS: One year after discharge, the experimental group achieved a significantly higher LVEF than the routine group (P < .05). After nursing intervention, the Morisky scores in both groups were increased, and the increase values was greater in the experimental group vs. routine group with respect to body mass index (BMI) control, medication adherence prescribed by a doctor, proper exercise, diet control (all P < .05); the experimental group exhibited superior performance in terms of disease, physical, medical, general life, social and psychological status, and work conditions than the routine group (all P < .05). After nursing intervention, the GSES score of the experimental group (29.14±2.56) was significantly higher than that of the routine group (21.35±2.74) (P < .05). Furthermore, the incidences of AMI and stent thrombosis in the experimental group (1.35%, 1.35%) were lower than they were in the routine group (9.46%, 14.87%); higher total satisfaction was observed in the experimental group vs. the routine group [71 (95.95%) vs. 53 (71.62%)] (P < .05).
CONCLUSION: Holistic nursing intervention emerges as a promising care strategy for AMI patients, demonstrating potential in enhancing treatment adherence, improving quality of life, fostering self-efficacy, and making positive contributions to prognosis and cardiac function. The observed effectiveness and safety profiles highlight the feasibility of this approach. In real-world clinical settings, the implementation of holistic nursing interventions may lead to improved adherence to treatment plans and an overall elevation in healthcare quality.
FIELD: organic chemistry, biotechnology. SUBSTANCE: invention relates to methods of isolation of biologically active content of natural compounds. Dried and milled fir wood green is extracted with tert.-butylmethyl ester, extract is treated with alkaline agent an aqueous solution, an aqueous-alkaline solution is separated and acidified to pH = 2. The end product is isolated from this solution by extraction with tert.-butylmethyl ester. EFFECT: simplified method, improved effectiveness. 2 dwg
During or immediately after the administration of Cyclophosphamide Capsules, adequate amounts of fluid should be ingested or infused to force diuresis in order to reduce the risk of urinary tract toxicity. Therefore, Cyclophosphamide Capsules should be taken in the morning.

Cyclophosphamide Capsules should be swallowed whole. The capsules should not be opened, chewed, or crushed. 

Cyclophosphamide Capsules is a cytotoxic drug. Follow applicable special handling and disposal procedures.1 Exposure to broken capsules should be avoided. If contact with broken capsules occurs, wash hands immediately and thoroughly.
Tissue inflammation is a hallmark of tumour microenvironments. In the bone marrow, tumour-associated inflammation impacts normal niches for haematopoietic progenitor cells and mature immune cells and supports the outgrowth and survival of malignant cells residing in these niche compartments. This Review provides an overview of our current understanding of inflammatory changes in the bone marrow microenvironment of myeloid and lymphoid malignancies, using acute myeloid leukaemia and multiple myeloma as examples and highlights unique and shared features of inflammation in niches for progenitor cells and plasma cells. Importantly, inflammation exerts profoundly different effects on normal bone marrow niches in these malignancies, and we provide context for possible drivers of these divergent effects. We explore the role of tumour cells in inflammatory changes, as well as the role of cellular constituents of normal bone marrow niches, including myeloid cells and stromal cells. Integrating knowledge of disease-specific dynamics of malignancy-associated bone marrow inflammation will provide a necessary framework for future targeting of these processes to improve patient outcome.