anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Difficult tracheal intubation is one of the major reasons for anesthesia-related adverse events. Patients undergoing ear, nose \& throat (ENT) or oral and maxillofacial (OMS) surgery often require tracheal intubation for general anesthesia but are at increased risk for difficult tracheal intubation. Currently, existing preoperative tests for the prediction of difficult intubation show low diagnostic accuracy. Moreover, as the results of these prediction tests are not coupled with concrete treatment recommendations, they cannot be used targeted within preventive concepts. An evidence based rational algorithm for the management of expected difficult intubation has not been developed yet. It is unknown, if an algorithm-based allocation to an intubation approach might be advantageous compared with a non-algorithm-based allocation strategy.

The Expect-it study aims to accompany the development and clinical implementation process of a new algorithm for the management of expected difficult intubation. This new algorithm is designed to provide an evidence-based decision-making tool for a rational pre-choice of tracheal intubation techniques, anesthetized intubation by direct laryngoscopy (DL) or videolaryngoscopy (VL) or awake tracheal intubation (ATI). In the first study phase the status quo (clinical standard, non-algorithm-based decision-making) will be assessed (three-month period with an approximated case number of up to 600 patients). The Expect-it algorithm will be implemented thereafter. Between both study phases, the algorithm will be updated (based on the findings of the first phase), sensitivity and specificity of the clinical standard will be calculated, sample size will critically be appraised and readjusted (approximately 600 within at least three months), if appropriate. The second study phase is a confirmatory diagnostic accuracy study for the new algorithm with a single test study design, that aims to proof, if the new Expect-it algorithm is superior or at least non-inferior to the clinical standard, defined as superiority in either the specificity or sensitivity and non-inferiority in the other co-primary endpoint in each domain (ATI, DL, VL) (pre-planned preliminary analysis of the first study phase; IRB amendment 2021-10459_2-BO-ff, December 3, 2021). Sensitivity and specificity are considered co-primary endpoints. Study planning and conduction is in accordance with the Standards for Reporting Diagnostic accuracy studies (STARD) statement. The Expect-it study will further include two surveys among anesthetist in the study center in order to evaluate challenges and obstacles associated with the implementation process and possible clinical implications of the algorithm. An additional analysis will be performed to test a core data set for an 'anesthesia alert card'.
Hyperphagia is highly penetrant in Prader-Willi syndrome (PWS) and has increasingly been reported in other neurogenetic conditions (NGC). The Hyperphagia Questionnaire (HQ) was completed by caregivers of 4-8-year-olds with PWS (n = 17), Angelman syndrome (AS; n = 22), Williams syndrome (WS; n = 25), or low-risk controls (LRC; n = 35). All NGC groups were significantly elevated in HQ Total and Behavior scores compared to LRC. Only AS and WS were significantly elevated in the Drive domain, and only PWS in the Severity domain. After controlling for externalizing behavior, HQ Total scores were higher for PWS relative to other groups. Hyperphagic symptoms may not differentiate PWS from other NGCs in early childhood. However, hyperphagic phenotypes may be most severe in PWS. Further investigation of these profiles may inform etiology and syndrome-specific treatments.
Up to 10 million children in the United States are exposed to DV directed at their mothers by intimate partners. DV exposure puts these children at an increased risk for developing behavioral problems, depression, anxiety, and PTSD. While studies targeting PTSD in DV-exposed children are limited, data indicates that TF-CBT is effective in improving PTSD as well as depression, anxiety, and behavioral symptoms. This study will determine the effectiveness of TF-CBT in reducing PTSD and other DV-related psychological symptoms in children from a community DV agency in Pittsburgh, Pennsylvania.

This study will last 8 weeks. Children and their mothers will be randomly assigned to receive 8 weeks of either TF-CBT or CCT. In TF-CBT, patients recall the events of their trauma and try to deal with the emotions that arise. Supportive treatment empowers children to deal with their emotions in general. Both the children and their mothers will complete questionnaires at study entry and at Week 8. Children will also complete self-report scales at study entry and at Week 8. The questionnaires and self-report scales will be used to assess symptoms of PTSD, depression, anxiety, and behavioral problems. Children and their mothers will be contacted 6 and 12 months after study completion for follow-up interviews.
Motor training is an important part of recovery after stroke. During motor training, stroke patients practice performing a movement and become better at performing the trained movement over time. Repetitive transcranial magnetic stimulation (rTMS), which uses magnetism to excite neurons near the surface of the brain, may further improve performance. Healthy adults made larger training-related improvements in their motor performance when they received rTMS over the primary motor cortex during motor training. There is evidence that the premotor cortex may be a more effective target than the primary motor cortex for rTMS for some stroke survivors. In the current study, the investigator will determine the effect of rTMS over the premotor cortex on training-related improvements in motor performance in healthy adults.
Participation in a functional training program in addition to usual care. The functional training program is initiated by the nurses and consists of walking, sit-to-stands, balance training, weight transfer training, knee squats. The program is performed 4 times a day for 3 weeks while at short-term stays.
PURPOSE:To prepare a therapeutic agent for nephritis such as chronic nephritic, acute nephritic and nephrotic syndromes or pyelonephritis, comprising a specific carbostyril derivative (salt) as an active ingredient and having suppressing action on urinary proteins and high therapeutic effects with hardly any side effects. CONSTITUTION:This therapeutic agent for nephritis is obtained by using a carbostyril derivative of the formula (R is benzoyl which may have a lower alkoxy group on the phenyl ring; the bond between the carbon atoms at the 3-and 4-positions of the carbostyril skeleton denotes single or double bond) {e.g. 6-[4-(3,4--dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril} and/or salt as an active ingredient, adding an additive such as an excipient (e.g. starch), a lubricant (e.g. magnesium stearate) and a disintegrating agent (e.g. lactose) thereto and forming the resultant blend into a tablet. This medicine has suppressing effects on urinary proteins such as chronic nephritic and nephrotic syndromes with hardly any side effects.
PURPOSE: A pharmaceutical formulation containing atorvastatin and candesartan as active ingredient is provided to reduce cholesterol synthesis. CONSTITUTION: A pharmaceutical formulation containing an immediate release compartment containing an atorvastatin as a pharmacologically active ingredient, its isomer, or its pharmaceutically active ingredient, a sustained release compartment containing candesartan as a pharmacologically active ingredient, its pharmaceutically acceptable salt or its prodrug. The release of candesartan starts 1 to 8 hours after atorvastatin release. The sustained release compartment contains a release control material selected from enteric polymer, water insoluble polymer, hydrophobic compound, hydrophilic polymer or their mixture. The pharmaceutical formulation is administered at night. The pharmaceutical formulation is used for preventing and treating cardiovascular diseases.
Women will complete their standard chemoradiation treatment protocol and end of treatment PET scan at about 3 months from completion of radiation. All interventions on this arm are standard of care.
PURPOSE: A nanoaggregate is provided to deliver a hydrophilic anticancer gene and a hydrophobic chemotherapeutic agent into a cell using one drug delivery system and to deliver an anticancer agent with high efficiency. CONSTITUTION: A nanoaggregate contains 1 micelle unit containing a hydrophobic chemotherapeutic agent conjugated to one end of a biocompatible non-ionic polymer and a hydrophilic anticancer gene conjugated to the other end of the biocompatible non-ionic polymer. The hydrophobic chemotherapeutic agent is conjugated to the biocompatible non-ionic polymer through a reduction-sensitive linker which is isolated under the presence of a reducing agent. The hydrophilic anticancer gene is conjugated to the biocompatible non-ionic polymer through a pH-sensitive linker which is isolated at pH 4-6. The 1 micelle unit has a structure of chemical formula 1. A method for preparing the nanoaggregate comprises: conjugating the hydrophobic chemotherapeutic agent at one end of the biocompatible non-ionic polymer through the reduction-sensitive linker; conjugating the hydrophilic anticancer gene to the other end through the pH-sensitive linker; and dispersing the complex containing the hydrophilic anticancer gene and the hydrophobic chemotherapeutic agent for self-assembling.
The control group will not participate in any exercise intervention. The participants in the control group will be explained the importance of a control group in RCTs and will be recommended to continue with their normal activity levels. They will however, be recommended to follow national guidelines for general exercise during pregnancy and will receive information about these guidelines (15).
Patients who are HMA-naive receive enasidenib PO QD on days 1-28 and azacitidine IV over 30-60 minutes or SC on days 1-7. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Serratus posterior intercostal plane block (SPSIPB) is a novel periparavertebral block. It provides anterolateral posterior chest wall analgesia. It is an interfascial plane block, performed under ultrasound guidance, and the visualization of landmarks is easy. It is performed deep into the serratus posterior superior muscle at the level of the third rib. Until now, there have been case reports about the usage of single-shot SPSIPB, but there are no reports about the usage of the block catheterization technique of SPSIPB. Continuous infusion from a catheter of interfascial plane blocks is important for postoperative analgesia management after painful surgeries such as thoracic and cardiac surgeries. Thus, we performed SPSIPB catheterization in a patient who underwent right atrial mass excision with minimally invasive thoracotomy surgery. Here, we present our successful analgesic experience with continuous SPSIPB in this case report.
This study was originally sponsored by BaroSense, Inc (protocol 11-03). 69 subjects were enrolled and treated as part of the study at 6 centers in 4 countries outside the United States. On April 30, 2013 BaroSense Inc went out of business and the study was terminated with all participating centers' Ethics Committees. At the point of study termination, all patients were in the middle of post procedure follow-up.

Boston Scientific has since acquired the technology and study and will re-initiate follow-up to 24 months in order to collect data to support the original safety and efficacy endpoints of the protocol. Only the 69 subjects previously enrolled and treated in BaroSense's protocol 11-03 will be eligible for participation in the Boston Scientific continued follow-up study ("The ACE Follow-up Study" protocol 90891629). The Boston Scientific protocol will be approved by participating centers' Ethics Committees and patients who choose to participate in The ACE Follow-up Study will need to sign a new, Ethics Committee Approved, informed consent form.
Ralfinamide was administered orally twice daily after breakfast and dinner. Participants on placebo in Study 304 were titrated over to rufinamide within 2 weeks during the Conversion Period. As a general rule, the dose of rufinamide at the end of the Conversion Period was maintained throughout the Maintenance Period.
Adipose tissue holds a pivotal position in maintaining systemic energy homeostasis. Brown adipose tissue (BAT) expresses uncoupling protein 1 (UCP1), which is specialized in dissipating chemical energy as heat to maintain euthermia, a process called non-shivering thermogenesis. Conversely, white adipocyte (WAT) predominantly serves as the primary reservoir for energy storage, while also exhibiting endocrine activity by secreting various adipokines, thereby modulating systemic metabolism. Under the stimulation of cold exposure, physical activity and pharmacological intervention, WAT can occur as "browning" or "beiging", and transform into beige adipose tissue. The morphology and function of beige adipocyte are similar to brown adipocyte, both of which express higher levels of UCP1 and also have the function of thermogenesis. Thus, exploring methods to regulate the functional homeostasis of adipose tissue and its underlying molecular mechanisms hold promise for advancing preventative and therapeutic approaches against metabolic diseases. Exosomes, a subtype of extracellular vesicles (EVs) with a diameter of 40-100 nm, facilitate intercellular communication in obese individuals and exert significant influence on insulin resistance and impaired glucose tolerance within adipose tissue. These effects are primarily mediated by microRNA (miRNA) transported by exosomes. MiRNA, originating from various cellular sources, traverses between different cell types via EVs, thereby orchestrating reciprocal functional modulation among diverse tissues and organs. This review systematically summarized the research progress in exosomal miRNA-mediated regulation of adipose tissue functional homeostasis, with the aim of offering novel insights into the diagnosis and treatment of obesity and associated metabolic diseases.
What do we, the people, have?—We have only the life. Our proposed BIOcultural microcomputers and microprocessor toys are to remind, what does shorten and depreciate our life. These microprocessor devices, as it turns out, have no analogs in the world are assigned for simple, easy-to-understand self-enlightening of an individual in fundamentals of BIOlogy concerning Life as such, as BIO, as natural phenomenon on the Globe and in organism of everybody. The BIOcultural microcomputers and microprocessor toys—these BIOenlightening microprocessor tools, autonomic and build-in, for instance, into cellular phones and personal computers, by auto-text or other audiovisual means, in playing or serious form, are to remind several times a day, on our private life as a constituent of the global Life, single and exclusive on the Globe and in our organism, non-submittable to us, existing beyond and independently of our consciousness—that is, on its turn, to remind on the existence of the Creator of Life and of us upon it. The databases in the said devises do contain a biological knowledge for an illustration to the user, that the “BIOcultural Way of Thinking” is a method, or an intellectual tool, or a mental technique, helping those who possesses it to come to correct conclusions in an analysis of four the most important and urgent methods for everyone on the Globe independently of sex, age, occupation, race, color of skin and place of residence: firstly, WHAT is correct to eat; secondly, HOW is correct to eat; thirdly, HOW is correct to live; and at last HOW is correct to support and restore the own health,—that is, from the point of biology, physiology and genetics. The algorithms in these devices enable the user to cognize this biological knowledge in an easy playing manner and then, gradually, to induce the user to live more comfortably by the further self-enlightening in the educational subject “BIOculture of the Individual” and by gradual turn to the own “BIOcultural Way of Thinking”.
Age-related hearing loss (HL), or presbycusis, is a complex and heterogeneous condition, affecting a significant portion of older adults and involving various interacting mechanisms. Metabolic presbycusis, a type of age-related HL, is characterized by the dysfunction of the stria vascularis, which is crucial for maintaining the endocochlear potential necessary for hearing. Although attention on metabolic presbycusis has waned in recent years, research continues to identify strial pathology as a key factor in age-related HL. This narrative review integrates past and recent research, bridging findings from animal models and human studies, to examine the contributions of the stria vascularis to age-related HL. It provides a brief overview of the structure and function of the stria vascularis and then examines mechanisms contributing to age-related strial dysfunction, including altered ion transport, changes in pigmentation, inflammatory responses, and vascular atrophy. Importantly, this review outlines the contribution of metabolic mechanisms to age-related HL, highlighting areas for future research. It emphasizes the complex interdependence of metabolic and sensorineural mechanisms in the pathology of age-related HL and highlights the importance of animal models in understanding the underlying mechanisms. The comprehensive and mechanistic investigation of all factors contributing to age-related HL, including cochlear metabolic dysfunction, remains crucial to identifying the underlying mechanisms and developing personalized, protective, and restorative treatments.
PURPOSE:To allow the washing in a raw material mixing tank to be executed with smaller energy in a short period of time by using a small amt. of paraffin by providing a liquid injecting device at the peak part of the raw material mixing tank and injecting liquid paraffin into the raw material mixing tank under heating of the raw material mixing tank. CONSTITUTION:A valve 30 in the bottom of the raw material mixing tank 1 is closed and a heat medium which is a heating oil is passed in a hose 2 to heat the inside surface of the tank 1 to a prescribed temp. The liquid paraffin of the same quality as the quality of the raw material liquid paraffin is then force fed from a washing tank 28 via a washing liquid supply pipe 25 by a pump 29 into a hollow spherical body 26 and is injected from a nozzle 27 into the tank. The injected liquid paraffin is then heated to the prescribed temp. while the liquid paraffin flows down on the inside surface of the tank 1 and is stored up to the level at which low-speed stirring vanes 3 and high-speed stirring vanes 4 are submerged. The tank 1 is internally washed by alternately rotating the vanes 3, 4 forward and backward respectively at prescribed rotating speeds, by which the remaining materials of the previous lot are removed.
This treatment incorporates a combination of cognitive-behavioral, motivational and education strategies. The program will be presented in 8 collaborative, multi-media, web based CBT sessions for BN.
The invention discloses a logistics dormant agent for keeping turbots alive without water and a preparation method thereof and relates to transportation for keeping fishes alive without water. The logistics dormant agent for keeping turbots alive without water is prepared from, by mass, 6-10 parts of valerian root powder, 2-10 parts of kamuning powder, 2-3 parts of polygonum cuspidatum powder, 4-6 parts of Pteris cretica L.var.laeta (Wall.) C.Chr.et Tard.-Blot[P.laeta Wall.] powder and 4-6 parts of melatonin. The preparation method includes the steps that firstly, the valerian root powder is prepared; secondly, the kamuning powder is prepared; thirdly, the polygonum cuspidatum powder is prepared; fourthly, the Pteris cretica L.var.laeta (Wall.) C.Chr.et Tard.-Blot[P.laeta Wall.] powder is prepared; fifthly, the valerian root powder prepared in the first step, the kamuning powder prepared in the second step, the polygonum cuspidatum powder prepared in the third step, the Pteris cretica L.var.laeta (Wall.) C.Chr.et Tard.-Blot[P.laeta Wall.] powder prepared in the fourth step, and the melatonin are poured into a powder mixer to be evenly mixed, and then the logistics dormant agent for keeping turbots alive without water is obtained. The logistics dormant agent for keeping turbots alive without water is mainly used in the induced dormancy link in the technology for keeping aquatic products alive without water, and various disadvantages existing in cold-acclimation induced dormancy are overcome.
OBJECTIVES: Research investigating the association between reproductive health and diet has predominantly focused on the antenatal and prenatal periods, as well as childbirth in women, and semen quality in men. There is a limited amount of research addressing female fertility assessed as ovarian reserve in relation to diet. The main aim of this study was to evaluate the association between dietary patterns and the parameters of ovarian reserve, such as antral follicle count (AFC), anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), and estradiol (E2) - predictors of reproductive health in women of childbearing age.
MATERIAL AND METHODS: Women aged 24-39 years (N = 511) were enrolled from fertility clinic in central Poland. The count of antral follicles was determined using ultrasonography (USG), FSH and E2 levels were measured using a chemilumi- nescence method and for determination of AMH level, an enzyme-linked immunosorbent assay method was employed. Diet was assessed according to food frequency questionnaire and dietary patterns were identified by factor analysis. Women were classified into 3 groups according to scores of each dietary pattern: Western, mixed, prudent.
RESULTS: Higher adherence to the prudent dietary pattern in obese women was associated with significantly higher AFC (p = 0.03) and AMH (p = 0.05) as compared to participants with the Western dietary pattern. The results were adjusted for age, BMI, smoking and duration of fertility. Increased consumption of mixed dietary pattern was not statistically significant associated with any of examined ovarian reserve parameters.
CONCLUSIONS: The prudent dietary pattern is positively associated with ovarian reserve in a cohort of women seeking fertility care. Continued research in this area will provide nutritional guidance for clinicians and their patients and provide novel insight on potential modifiable lifestyle factors which can be associated with ovarian reserve. Int J Occup Med Environ Health. 2024;37(4):411-20.
The NeuroTrainer intervention involves using a VR-based cognitive training program designed to improve attention and executive function in students with ADHD. Participants will engage in 30-minute sessions, approximately three times a week for 12 weeks, performing game-like tasks that integrate physical activity and adapt to their performance level.
Exposure therapy will involve three, 10-minute trials in which participants encounter a spider. Participants in this group will wear protective gear during the first two trials, and will remove the protective gear during the last trial.