anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention belongs to the field of nursing, and particularly relates to treatment of a forearm ecchymosis hematoma patient after a radial artery interventional operation. The traditional Chinese medicine composition for eliminating ecchymosis comprises the following components: comprises 400 portions of 100-400 portions of safflower, 400 portions of 100-400 portions of salvia, 400 portions of panax notoginseng, 50-250 portions of angelica, 50-250 portions of notopterygium root, 50-250 portions of pubescent angelica root, 20-200 portions of divaricate saposhnikovia root and 20-200 portions of liquorice. The preparation method comprises the following steps: soaking 60% of medicinal materials in 95% ethanol for swelling for 24 hr, placing in a percolation barrel, percolating with 95% ethanol as solvent at flow rate of 2ml/min, and collecting percolate 50 times of the medicinal materials; grinding Borneolum Syntheticum, dissolving in 95% ethanol, mixing with percolate, stirring, sealing, and standing. When in use, the traditional Chinese medicine composition is soaked in alcohol and glycerol for wet dressing, the sterile gauze soaked with the wet medicine is applied to the hematoma part, the wet dressing area exceeds the edge of the hematoma, and a disposable sterile towel is wrapped on the outer layer. Raise the limb 30 degrees below the elbow joint. Keeping the wrist joint straight, and replacing the gauze for 4h for 1 time and 2 times per day for three consecutive days.
The study consisted of a 24-week double-blind, placebo-controlled treatment period followed by an open-label period of approximately 108 weeks. Participants were eligible to enter the open-label period of the study early if they did not achieve a response at week 8 and had an inadequate response at week 12 or later or if they experienced disease worsening after achieving response and/or remission at week 8. Failure to achieve response at week 8 was defined as failure to achieve a decrease from baseline in total Mayo Score ≥ 3 points and ≥ 30% decrease from baseline. Inadequate response at week 12 or later was defined as failure to achieve a 2-point decrease and 25% improvement in partial Mayo Score compared with screening and minimum partial Mayo Score ≥ 5 points. Disease worsening was defined as an increase in partial Mayo Score ≥ 3 points from the week 8 value and minimum partial Mayo Score ≥ 5 points with recto-sigmoidoscopy sub-score ≥ 2.

Participants were planned to be randomized in a 2:1:2:2:2 ratio to placebo or abrilumab at 7 mg, 21 mg, 70 mg (on day 1, week 2, week 4, and every 4 weeks thereafter until week 24), or 210 mg (on day 1 followed by placebo in weeks 2 and 4 and every 4 weeks thereafter until week 24), respectively. Due to a consistent discrepancy between the investigational product (IP) instruction manual (IPIM) description of vial positions and the actual vial positions in the IP package participants were initially randomized to 3 arms (placebo, 70 mg, and 210 mg) with a randomization ratio of 4:3:2. The study was temporarily paused while this issue was investigated. Once the discrepancy was corrected, Protocol Amendment 3 implemented, and affected participants completed their double-blind treatment period, the study resumed enrollment and randomization per protocol. Neither the randomization nor study blind was compromised and therefore the intent-to-treat principle was maintained.
The intermittent graded exercise test (INT) increase treadmill speed incrementally using three minute stage duration on a motorised treadmill. However, the speed within each three minute exercise bout will vary every 30 s between the target speed, and a complete pause for 30 s. The acceleration of the treadmill belt will be set to its maximum capability.
Traditional Chinese medicine thinks that the head is the first of all yangs, and the white hair is tightly related to the liver, the kidney, twelve meridians, eight extra channels and twelve cutaneous areas. In a human body, the kidney is in charge of generating marrows in bones and externally represents in hair. The invention relates to a medicament for treating the white hair through external washing, which comprises a plurality of natural famous and precious plants of tea bran, ginger, prepared tuber fleeceflower root, black sesame seed, eclipta and the like. Firstly, the hair is cleaned by using the tea bran, and then the hair is washed by using raw ginger liquid and traditional Chinese medicines, massaged for 30min and finally sprayed by using the traditional Chinese medicine liquid. Various diseases can be treated by washing the head with traditional Chinese medicine, and the principle is the same with the oral administration and is only different from the administration path. The medicament is firstly fed into the stomach and conveyed to the whole body after being cleaned by the turbid, dregs of the medicament can not enter the channels, and components of the medicament entering the channels are tastes of the medicament. An external washing medicament is fed into the skin of the head and can penetrate through the hair root, and the taste of the medicament penetrates through the skin and reaches the channels to be taken into the body, fused into the body fluid and combined with the body fluid into one whole to achieve the advantages of inside and outside consistency. Through external washing, the nutrition of hair follicles is completely conditioned, the nutrition of melanocyte cells is replenished, and the diacrisis of the melanocyte cells is improved, thus the white hair condition is changed.
PROBLEM TO BE SOLVED: To produce a composition for skin lotion such as cosmetic or pharmaceutical for skin lotion, having stable system and excellent safety, free from nonionic surfactant and suitable for the conditioning of skin by including a mucopolysaccharide having sulfate group and a polymer having an alkyl group. SOLUTION: The objective composition contains (A) one or more kinds of mucopolysaccharide having sulfate group (chondroitin sulfates such as chondroitin sulfate and dermatan sulfate, heparins or heparin-analog substances such as keratan sulfate and chondroitin polysulfate, etc.), and (B) a polymer having an alkyl group [e.g. an alkyl (meth)acrylate copolymer]. The composition is preferably further incorporated with (C) an unsaturated higher alcohol ether of a polyhydric alcohol (e.g. glycerol). Preferable content of each component is 0.001-10 wt.%, especially 0.05-5 wt.% for the component A, 0.01-2 wt.%, especially 0.05-1 wt.% for the component B and 0.01-5 wt.%, especially 0.1-3 wt.% for the component C.
The invention discloses a Chinese medicinal formula for treatment of biliary duct ascarides. Each dose of the traditional Chinese medicine is prepared from the following medicinal materials by mass: 45-50g of Zanthoxylum nitidum, 40-45g of Cudrania cochinchinensis, 45-50g of Mahonia fortune, and 45-50g of porcupine spine. The traditional Chinese medicine is decocted and is then taken orally three times a day, 50-80ml each time. The traditional Chinese medicine can effectively get rid of biliary duct ascarides, one day is a course of treatment, after taking the medicine  once, pain disappears, and ascarides get out of the biliary duct, on the next day of pain disappear, an anthelmintic can be taken to get rid of ascarides, and the effective rate is more than 95%. The traditional Chinese medicine can avoid surgery, release patients from suffering surgical pain, and also greatly reduces the economical burden of patients. The traditional Chinese medicine is easy to prepare, and causes no adverse reaction during taking.
A computer-executable method for financial retirement planning that provides a comparative evaluation of a plurality of health care funding alternatives. The comparative evaluation enables individuals to select one or more funding alternatives appropriate to their particular set of circumstances. The method commences by calculating overall cash flow for an individual, a couple, and/or a family during retirement. Based upon this cash flow, an amount representing an affordable heath care insurance premium is determined. Next, a comparison of projected retirement finances is provided. This comparison provides (a) financial projections assuming that long-term health care will not be required, (b) financial projections if long-term health care is required, but the individual is not covered by insurance, and (c) financial projections if long-term health care is required, and the individual is covered by insurance. The financial projections include a level of attainable retirement spending per week, month, and/or year. Optionally, the projections include a low-cost estimate, an average cost estimate, and a high-cost estimate for the expenses of long-term health care and/or health care insurance.
OBJECTIVES: Botulinum toxin is used in human in repeatedly masticatory muscles injections. A single BTX injection in animal induces mandibular bone loss with a muscle enthesis hypertrophic metaplasia. Our aim was to evaluate mandibular bone changes after unilateral repeated injections of BTX in adult rats.
STUDY DESIGN: Mature male rats were randomized into 3 groups: one, two or three injections. Each rat received injections in right masseter and temporalis muscles. The left side was the control side. Microcomputed tomography was used to perform 2D and 3D analyses.
RESULTS: Bone loss was evidenced on the right sides of alveolar and condylar bone. Alveolar bone volume increased in both control left side and injected right side whereas condylar bone volume remained constant in all groups, for both sides. Enthesis bone hypertrophic metaplasias were evidenced on the BTX injected sides without any modification with the number of injections.
CONCLUSION: BTX repeated injections in masticatory muscles lead to major mandibular condylar and alveolar bone loss that does not worsen. They lead to the occurrence of an enthesis bone proliferation that is not dependent on the number of injections. These results are an argument for the safety of BTX injections in masticatory muscles in human.
<P>PROBLEM TO BE SOLVED: To obtain a drug reducing the amount of an anesthetic used by enhancing the anesthetic depth in balanced anesthesia, rapidly awakening after completing administration and ameliorating symptoms.  <P>SOLUTION: A combined agent is prepared by combining the anesthetic with landiolol hydrochloride. The landiolol hydrochloride represented by the formula has short-time type β<SB>1</SB>receptor blocking actions and further actions on deepening the depth of the anesthetic. Thereby, since the amount of other anesthetics used can be reduced by using the landiolol hydrochloride, the agent is useful as an anesthetic adjuvant. Since this compound has a short half-life, the awakening time from the anesthesia is short and refreshing awakening can be promoted for patients. Thereby, the symptoms during awakening can be ameliorated.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The present invention relates to a mixture of natural polyphenols with antioxidant capacity and cardiosaludable properties; the base mixture comes from the combination of natural grape extracts (including skin, seeds and grape leaves), onion and pomegranate, obtained under pressure. The active principles to be included in the final preparation; - trans-resveratrol. Assuming an average concentration of this compound in red wine of 5 mg/liter, and that moderate consumption of red wine has been associated, in epidemiological studies, with a beneficial effect on cardiovascular mortality, a supplement of between 3-5 mg is proposed newspapers. 150 mg of daily quercetin. - 300 mg of daily ellagitannins in the form of punicalgins. (Machine-translation by Google Translate, not legally binding)
FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to a mixture of primary fatty acids preparing from myar cane wax. New mixture of primary high-molecular natural fatty acids comprises from 24 to 38 carbon atoms, preferably from 26 to 36 carbon atoms and mostly preferably they have unbranched chain comprising 26, 28, 29, 30, 31, 32, 33, 34, 35 and 36 carbon atoms. This mixture shows high reproducibility by composition of fatty acids from lot to lot and it is isolated from myar cane (Saccharum officinarum L.) wax. This mixture of fatty acids shows definite pharmacological properties that allow its using as the main active component in pharmacological compositions used as hypocholesterolemic properties and against hypercholesterolemia of II-type, anti-thrombocytopathy, as anti-thrombotic, anti-ischemic agents. This mixture of primary fatty acids is effective also in inhibition of development of stomach ulcers caused by different agents. Invention provides application of natural mixture of fatty acids in relatively low doses. EFFECT: valuable medicinal properties of fatty acids. 14 cl, 9 tbl, 10 ex _
The utility model provides a sheep placenta extract freeze-dried powder production system belongs to food processing technology field. Comprises a thawing device, a high-pressure cooking kettle, an enzymolysis tank, a filter tank, an enzymolysis tank and a freeze dryer which are arranged in sequence. The unfreezing device comprises a unfreezing groove and a draining groove, a transmission roller set is arranged at the bottom of the unfreezing groove and the bottom of the draining groove, a slope angle which is gradually lifted is arranged at the bottom of the unfreezing groove, an inlet of the draining groove is communicated with one end, close to the high position of the slope angle, of the unfreezing groove, and a water collecting tank is arranged below the transmission roller set. The high-pressure cooking kettle is communicated with the outlet of the draining tank, the enzymolysis tank is communicated with the outlet of the high-pressure cooking kettle, the filter tank is communicated with the outlet of the enzymolysis tank, the enzymolysis liquid tank is connected with the outlet of the filter tank, and the freeze dryer is connected with the enzymolysis liquid tank through a sliding rail. The system forms an integrated production system, can be realized only by a small amount of manual intervention in the whole process, reduces the labor cost and improves the labor efficiency. And the whole production process is carried out in a closed space, so that the sanitation, safety and reliability of the production process are effectively improved.
This group consisted of 114 participants who only received a piece of educational material every five days at a random time between 8 am and 9 am. The educational materials sent to this group were general medical information, which were not specifically about improving medication adherence or preventing coronary heart disease.
This will consist of patients who are ASA I or II status, 3-8 years old, males and females, and present with restorable primary molars with reversible pulpitis and free of clinical radiographic signs of pulp pathology. From these study participants, they will be randomly assigned to this or other group. Patients in this group will receive a pulpotomy. Cotton pellets are saturated with conventional 1:5 dilution of Buckley's formocresol into the canal orifice for 5 minutes for complete hemostasis. IRM (Zinc Oxide Eugenol) cement will then be placed to seal the pulp chamber. A stainless steel crown will be cemented with Ketac Cement that was triturated for 10 seconds to complete the pulpotomy procedure and final restoration.
The use of a carvacrol and thymol composition for inhibiting an increase in the prevalence of cephalosporin-resistant Enterobacteriaceae in a bacterial population exposed to a cephalosporin antimicrobial is provided. The cephalosporin-resistant Enterobacteriaceae may be exposed to a cephalosporin antimicrobial in a milk product wherein the milk product is preferably milk, colostrum, transitional milk or calf milk replacer. The carvacrol and thymol composition may preferably be for inhibiting the increase in the prevalence of cephalosporin-resistant Enterobacteriaceae in a bacterial population exposed to a cephalosporin antimicrobial in the gut of a pre-ruminant or ruminant animal. Preferably the cephalosporin-resistant Enterobacteriaceae is E. coli. Preferably the carvacrol and thymol composition comprises oregano essential oil. The cephalosporin antimicrobial is preferably a third or fourth generation cephalosporin. An animal feed, feed supplement or feed ingredient comprising the carvacrol and thymol composition is also provided.
PURPOSE: A multimedia medical data diagnosis system using a PHR(Personal Health Record), a device thereof, and a method thereof are provided to enable a PHR reader to perform PHR remote reading at an undesignated hospital through a virtual IP, and to scan a predetermined part of a PHR header file. CONSTITUTION: A thread setup module(121) sets the number of terminals which can simultaneously access. An IP control module(122) controls access by checking IPs of the terminals. If the IPs are virtual IPs, the IP control module converts the virtual IPs into authorized IPs. A list providing module(123) provides a reading terminal list for reading multimedia medical data. [Reference numerals] (121) Thread setup module; (122) IP control module; (123) List providing module; (124) Header scan module; (125) Synchronization module; (126) Medical insurance management module; (127) Control module
The intrahippocampal kainic acid (IHKA) mouse model is an extensively used in vivo model to investigate the pathophysiology of mesial temporal lobe epilepsy (mTLE) and to develop novel therapies for drug-resistant epilepsy. It is characterized by profound hippocampal sclerosis and spontaneously occurring seizures with a major role for the injected damaged hippocampus, but little is known about the excitability of specific subregions. The purpose of this study was to electrophysiologically characterize the excitability of hippocampal subregions in the chronic phase of the induced epilepsy in the IHKA mouse model. We recorded field postsynaptic potentials (fPSPs) after electrical stimulation in the CA1 region and in the dentate gyrus (DG) of hippocampal slices of IHKA and healthy mice using a multielectrode array (MEA). In the DG, a significantly steeper fPSP slope was found, reflecting higher synaptic strength. Population spikes were more prevalent with a larger spatial distribution in the IHKA group, reflecting a higher degree of granule cell output. Only minor differences were found in the CA1 region. These results point to increased neuronal excitability in the DG but not in the CA1 region of the hippocampus of IHKA mice. This method, in which the excitability of hippocampal slices from IHKA mice is investigated using a MEA, can now be further explored as a potential new model to screen for new interventions that can restore DG function and potentially lead to novel therapies for mTLE.
PCT No. PCT/US94/14639 Sec. 371 Date Aug. 1, 1996 Sec. 102(e) Date Aug. 1, 1996 PCT Filed Dec. 20, 1994 PCT Pub. No. WO95/17169 PCT Pub. Date Jun. 29, 1995Disclosed is a method of dry blend compression of potent drugs with low solubility, such as steroidal medicaments using directly compressible agglomerated excipients that are not a conventional or spray dried polyalcohol or lactose. The agglomerated excipients include mannitol, maltodextrin or corn syrup solids, which hold the medicament(s) in the crevices of the agglomerates. Also disclosed are the critical ratios of the agglomerated excipients to steroidal agent, specifically estradiol, that is distributed uniformly throughout the dry blend and then compressed into tablets.
Patients receive buparlisib as in Cohort A and ibrutinib PO on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
This randomized, blind controlled trial has the objective of evaluate colorimetric changes after supervised whitening treatment, in-office, using Violet LED light of 405 nm associated or not to the use of carbamide peroxide 35% gel. Eighty patients, of which 20 with aesthetics desires to be submitted to gingivoplasty surgery, will be divided into four groups. Group 1 will receive whitening only with Violet LED light (405 nm). Group 2 will receive a whitening treatment combination of Violet LED light with carbamide peroxide 35% gel. Patients of Group 3 will receive a whitening treatment with hydrogen peroxide 35% and Group 4 will be submitted to the gingivoplasty surgery procedure, for aesthetic desire, after whitening treatment with Violet LED light (405 nm) without gel. The colorimetric changes will be measured before, right after each whitening session in the end of the period of 3 months, through the Vitapan Classical (Vita) color scale, and by digital spectrophotometer (SpectroShade™ Micro MHT Optic Research). The sensibility degree will be measured by the Visual Analogue Scale (VAS) in each session and in all groups. The gum tissues removed during the gingivoplasty in Group 4, will be histomorphometric analyzed to measure possible inflammatory gum changes by the Violet LED light (405 nm) irradiation. The degree of satisfaction of the patient and the life quality after aesthetic result achieved will be evaluated. The results will be presented by means and standard deviation. After checking the normality of the data, a one-way ANOVA will be performed. In case the data do not follow a normal distribution, it will be utilized the Kruskal-Wallis test and a value of p \<0.05.
Each subject was given 3 injections in lateral gastrocnemius muscle:2 botox, 1 saline, each injection was 2.5mL. MRI of the lower leg was taken prior to injections and 2 months post for a comparison of diffusion properties.
FIELD: medicine. SUBSTANCE: cellular strain НАЗ-15 is adopted for diploid culture of human fibroblasta JI-68 and purified then by molecular-sieve chromatography or ultracentrifugation in gradient of CsCl. Method ensures to obtain fully safe vaccine preparation with regard to oncogenicity and showing high degree of immunogenicity. Method can be used in vaccine preparation production. EFFECT: simplified and accelerated method of vaccine preparing against hepatitis A. 1 tbl
This is a randomized (the treatment group is assigned by chance), double-blind (neither physician nor patient knows the treatment that the patient receives) placebo (an inactive substance that is compared with a drug to test whether the drug has a real effect in a clinical trial)-controlled study with a randomization allocation ratio of 2:1 between the abiraterone acetate group (abiraterone acetate plus prednisone) and the placebo group (placebo plus prednisone). Approximately 200 (133 in the abiraterone acetate group and 67 in the placebo group) medically or surgically castrated male patients with mCRPC who have failed docetaxel-based chemotherapy will be enrolled in this study for up to 27 months. The study protocol includes the following phases: screening (within 28 days prior to randomization on Cycle 1 Day 1), double-blind treatment (28-day cycles until protocol-defined disease progression or unacceptable toxicity), and survival follow-up (up to Month 60). During the follow-up phase, patients with disease progression will be provided open-label (identity of assigned study drug will be known) extension treatment with abiraterone acetate. In the event of a positive study result at the time of the final analysis, participants in the placebo group who have not shown progressive disease in the double-blind treatment Phase of the study will be enrolled in an open-label extension treatment with abiraterone acetate treatment based on the participant's choice and treating physician's endorsement if they meet the criteria for subsequent abiraterone acetate. Abiraterone acetate 1000 mg tablets or placebo will be taken orally (by mouth) once daily plus prednisone 5 mg tablet orally twice daily. Efficacy and safety will be monitored throughout the study.