anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Cryptosporidiosis, a zoonotic infection impacting both livestock and humans, is inadequately understood in terms of its prevalence and transmission dynamics involving buffaloes in Bangladesh. This research, conducted in the Sylhet division, aimed to explore the prevalence and potential risk factors influencing Cryptosporidium spp. in the faecal samples of 392 buffaloes. Detection of the parasite utilized modified Ziehl-Neelsen staining, with molecular identification achieved through nested PCR (nPCR). The comprehensive analysis revealed 9.18% (36/392) prevalence at the individual animal level and 40.48% (17/42) at the herd level. Age-based analysis revealed fluctuating infection rates of Cryptosporidium spp. in buffaloes across distinct age brackets, with rates of 22.61% in those aged 0-6 months, 5.00% in those aged 6-12 months, and 1.03% in those aged 12-18 months. Diarrheic buffaloes showed a significantly (p < 0.001) higher infection rate (26.67%; 28/105) compared to non-diarrheic buffaloes (2.79%; 8/287). In risk factor analysis, binary logistic regression revealed that buffaloes aged 0-6 months were experiencing a likelihood that is 14.84 times higher to be affected by Cryptosporidium in contrast to their older counterparts (OR = 14.85; p = 0.02). Additionally, diarrhoeic buffaloes were found to be more susceptible to Cryptosporidium compared to healthy buffaloes (OR = 17.50; p < 0.001). A higher stocking density was associated with an increased likelihood of infection in buffaloes (OR = 11.20; p = 0.01). The results of this study emphasize the necessity for targeted interventions, considering factors like diarrheic condition and stocking density, to effectively manage and control cryptosporidiosis in Bangladesh.
The invention provides a preparation process of pure natural nano-ultrafine calcium powders. The preparation process comprises the steps of primary stirring, secondary stirring and third stirring. Based on the preparation process, the production efficiency of calcium powders is improved and the labor time is reduced. Meanwhile, the cost of calcium powders is reduced. When prepared pure natural nano-ultrafine calcium powders are applied to a rubber product, the tensile strength of the rubber product can be up to 14. 8 MPa, and the breaking elongation rate thereof is up to 620%. Meanwhile, the tearing strength of the rubber product reaches 35-38 KN/m. When prepared pure natural nano-ultrafine calcium powders are applied to a pharmaceutical product, the bone mass can be effectively reduced and the recovery rate of osteoporosis patients is up to 84-96%. The symptoms of osteoporosis are greatly alleviated.
The present invention relates to the use of glutamine synthetase for the treatment of hyperglycaemia. The present invention relates to the use of glutamine synthetase as a protein therapy (such as enzyme replacement protein therapy) for treating hyperammoniacal disorders. In particular, the invention relates to systemic administration of glutamine synthetase. Glutamine synthetase can be provided in conjugated or fused form to increase its half-life in circulation. Pharmaceutical compositions comprising glutamine synthetase are also provided. The invention also relates to uses, methods and compositions comprising a combination of a glutamine synthetase protein and a ammonia reducing agent such as a nitrogen scavenger.
In order to investigate the effectiveness and safety of miR-23b-3p in anti-seizure activity and to elucidate the regulatory relationship between miR-23b-3p and Cx43 in the nervous system, we have established a lithium chloride-pilocarpine (PILO) status epilepticus (SE) model. Rats were randomly divided into the following groups: seizure control (PILO), valproate sodium (VPA+PILO), recombinant miR-23b-3p overexpression (miR+PILO), miR-23b-3p sponges (Sponges+PILO), and scramble sequence negative control (Scramble+PILO) (n = 6/group). After experiments, we got the following results. In the acute phase, the time required for rats to reach stage IV after PILO injection was significantly longer in VPA+PILO and miR+PILO. In the chronic phase after SE, the frequency of spontaneous recurrent seizures (SRSs) in VPA+PILO and miR+PILO was significantly reduced. At 10 min before seizure cessation, the average energy expression of fast ripples (FRs) in VPA+PILO and miR+PILO was significantly lower than in PILO. After 28 days of seizure, Cx43 expression in PILO was significantly increased, and Beclin1expression in all groups was significantly increased. After 28 days of SE,the number of synapses in the CA1 region of the hippocampus was significantly higher in the VPA+PILO and miR+PILO groups compared to that in the PILO group. After 28 days of SE ,hippocampal necrotic cells in the CA3 region were significantly lower in the VPA+PILO and miR+PILO groups compared to those in the PILO group. There were no significant differences in biochemical indicators among the experimental group rats 28 days after SE compared to the seizure control group. Based on the previous facts, we can reach the conclusion that MiR-23b-3p targets and blocks the expression of hippocampal Cx43 which can reduce the formation of pathological FRs, thereby alleviating the severity of seizures, improving seizure-induced brain damage.
The blood samples will be collected according to the site's routine clinical practice usually prior to each treatment cycle and at the follow-up visits. Analysis of the RAS mutation status will be carried out on blood samples taken at baseline, on those carried out at 20 +/-2 weeks after the start of treatment (in any case, prior to the second tumour assessment) and on the sample obtained upon progression, coinciding with routine clinical practices for collecting blood. Blood Samples will be collected to all subjects participating (119 subjects.)Objective to evaluate the RAS mutation status at baseline in liquid biopsies in subjects with RAS wild type metastatic colorectal cancer.
The conventional rehabilitation program will consist of physiotherapy sessions (100 min/day) following an individualized approach. The program aims at the restoration of mobility and daily living competence, Specific exercises for the affected upper limb will include, bilateral tasks and facilitation techniques based on neuro-developmental treatment.
The invention discloses cra4S1 Genes of the order of cra4S1 The nucleotide sequence of the gene is shown in SEQ ID NO: 1. The invention also discloses cra4S1 Cra4S1 protein coded by the gene and application thereof. The invention also discloses a vaccine or medicine, which comprises the Cra4S1 protein or the fragment thereof. The periodontal disease vaccine related to the invention combines the specific target of the outer membrane protein of the porphyromonas gingivalis and the newly discovered antigen component of the bacterial conservation area, and the novel vaccine not only plays an immunoprotection role on an uninfected organism, but also plays an obvious immunoprotection role on an already infected organism. When specific antibodies against the dual targets are used in combination, both the infected and the uninfected organisms produce significant immunoprotection against bacterial attack. In addition, when the product contains Cra4S1 protein or Cra4S1 protein antibody component, the stability of the product is improved.
In today's digital world, with growing population and increasing pollution, unhealthy lifestyle habits like irregular eating, junk food consumption, and lack of exercise are becoming more common, leading to various health problems, including kidney issues. These factors directly affect human kidney health. To address this, we require early detection techniques that rely on text data. Text data contains detailed information about a patient's medical history, symptoms, test results, and treatment plans, giving a complete picture of kidney health and enabling timely intervention. In this research paper, we proposed a range of sophisticated models, such as Gradient Boosting Classifier, Light GBM, CatBoost, Support Vector Classifier (SVC), Random Boost, Logistic Regression, XGBoost, Deep Neural Network (DNN), and an Improved DNN. The Improved DNN demonstrated exceptional performance, with an accuracy of 90 %, precision of 89 %, recall of 90 %, and an F1-Score of 89.5 %. By combining traditional machine learning and deep neural networks, this integrative approach enables the identification of intricate patterns in datasets. The model's data-driven processes consistently update internal parameters, guaranteeing flexibility in response to evolving healthcare settings. This research represents a notable advancement in the progress of creating a more detailed and individualised ability to diagnose kidney stones, which could potentially lead to better clinical results and patient treatment.
INTRODUCTION: This prospective study compared pain perception, intensity, and analgesic use among patients treated with fixed appliances (FAs) and clear aligners (CAs) over 6 months.
METHODS: Digital surveys were collected from 87 adult patients treated with CA or FA from 2 orthodontic offices. The 7-item survey was sent at 3-time points (preappointment, 2-day postappointment, and 7-day postappointment) for each appointment. Wilcoxon, t test, and Fisher exact chi-square tests were performed with significance set at 0.05.
RESULTS: The FA group had a higher rate and intensity of pain 2 days after the second, third, and fifth appointments (P <0.030). At 7 days postappointment, the FA group had a higher rate and intensity of pain for the first and fifth appointments. Dull pain was reported the most in both groups, with a proportion of FA patients reporting throbbing (31%) or sharp (20%) pain (P = 0.035) at 2 days postappointment. The CA group reported the most pain at rest, whereas the FA group reported chewing as the most painful (P = 0.002). The FA group had a higher rate of analgesic consumption after the first appointment (P = 0.037).
CONCLUSIONS: Both the FA and CA groups experienced similar rates and intensities of pain 2 days after the delivery of appliances at the first appointment. Although CA pain intensity remained minimal, FA pain peaked 2 days postappointment whenever a new orthodontic stimulus was introduced and remained elevated 7 days postappointment when that stimulus was a new archwire material.
Neuroinflammation is a significant pathological event involving the neurodegenerative process associated with many neurological disorders. Diagnosis and treatment of neuroinflammation in its early stage are essential for the prevention and management of neurological diseases. Herein, we designed macrophage membrane-coated photoacoustic (PA) probes (MSINPs), with targeting specificities based on naturally existing target-ligand interactions for the early diagnosis of neuroinflammation. The second near-infrared dye, IR1061, was doped into silica as the core and was encapsulated with a macrophage membrane. In vitro as well as in vivo, the MSINPs could target inflammatory cells via the inflammation chemotactic effect. PA imaging was used to trace the MSINPs in a neuroinflammation mouse model and showed a great targeted effect of MSINPs in the prefrontal cortex. Therefore, the biomimetic nanoprobe prepared in this study offers a new strategy for PA molecular imaging of neuroinflammation, which can enhance our understanding of the evolution of neuroinflammation in specific brain regions.
Useful material for making low-dose radiographing and an increase in the image quality compatible with each other is provided. An image analysis unit of a central server derives the granularity of a region of interest by analyzing an X-ray image transmitted from a client terminal. A storage processing unit stores the granularity, the X-ray image, and radiographing information in a storage device so as to be associated with each other. A search processing unit searches for the radiographing information, which is matched with search conditions designated from the client terminal, and granularity, which is associated with the radiographing information, from the storage device. A statistical data generation unit generates a scatter plot, which has granularity on the vertical axis and a radiation dose on the horizontal axis, as statistical data. The statistical data is transmitted to the client terminal and is displayed on a display of the client terminal.
The invention relates to a medicament for treating gastritis and duodenal ulcer quickly. The medicament is effective in treating gastritis and duodenal ulcer in the medical field, is prepared from a variety of Chinese medicinal herbs and can be used for overcoming the defects that the existing medicaments only have the effects of neutralizing and inhibiting the gastric acid and have no effects of diminishing inflammation reasonably. The medicament has the advantages of promoting digestion and absorption and regulating and normalizing the secretion of digestive juices in the stomach and the intestines so that the stomach and the intestines can absorb the medicament quickly, the effect of the medicament is improved, the stomach content (food) emptying time becomes normal, the burden of the stomach and the intestines is reduced and the appetite of the patient becomes normal naturally. The valuable reasonable Chinese medicinal herbs have the effects of resisting bacteria, diminishing inflammation and repairing the ulcerous surface so that the inflammation and the ulcerous surface can be eliminated and healed effectively and quickly. The stomach and intestine spasmolysis and smooth muscle relaxation Chinese medicinal herbs are more beneficial to the inflammation diminishing components and the ulcerous surface repairing components of the medicament to cover the diseased parts so that the stomach and intestine discomfort can be relieved timely, the inflammation of the diseased parts can be diminished and the diseased parts can be repaired. The medicament has the efficacy of building body, enhancing the physical fitness and shortening the treatment time.
The standard treatment for extensive burn wounds is transplantation with meshed split skin graft. Disadvantages of this treatment are that healing of large full thickness burn wounds is still accompanied by scar formation. Even standard treatment, transplantation with a (meshed) split skin autograft, does not result in satisfactory functional and cosmetic appearance of the healed wound. Due to limited available donor sites meshes needs to be enlarged. Bigger enlargements of meshes give more scarring and mesh pattern are still visible in scars, probably because wound closure still needs several weeks. Application of cultured autologous keratinocytes may enhance wound closure and improve outcome of healing.

Primary objective: Does the application of cultured autologous keratinocytes on deep burn wounds accelerate wound closure Secondary objectives: Does the application of cultured autologous keratinocytes on deep burn wounds improve scar quality with respect to scar elasticity, colour/pigmentation and/or smoothness after 3 and 12 months.
Participants received carfilzomib 20 mg/m² administered by intravenous infusion over 30 minutes on Cycle 1 Days 1 and 2 only, then 45 mg/m² on Days 8, 9, 15 and 16 and thereafter for the remainder of treatment. All participants with stable disease or better after 2 cycles could continue treatment until progressive disease or unacceptable toxicity.
Background and Objectives: In this study, the effects of a six-week training program and various diets on subfatin, asprosin, irisin, leptin, ghrelin and the lipid profile were investigated in overweight women. Materials and Methods: A total of 78 women voluntarily participated in the study. Groups: The study was divided into eight groups: Healthy Control, Obese Control, Obese + Vegetarian, Obese + Ketogenic, Obese + Intermittent Fasting, Obese + Exercise + Vegetarian, Obese + Exercise + Ketogenic and Obese + Exercise + Intermittent Fasting. While there was no intervention in the healthy and obese control groups, the other groups followed predetermined exercise and diet programs for 6 weeks. Blood samples were taken from the participants in the research group twice (before and after the interventions). An autoanalyzer was used to determine the lipid profile in the blood samples taken, and the ELISA method was used to analyze other parameters. Results: Overall, a significant difference was found in the values of weight, BMI, subfatin, ghrelin, leptin, cholesterol, triglyceride, HDL and LDL as a result of the exercise and diet interventions (p < 0.05). There was no significant difference in asprosin and irisin values (p > 0.05). Conclusions: In conclusion, regular exercise and dietary interventions in obese women can regulate lipid profile, ghrelin, leptin and asprosin levels, and increasing irisin with exercise can activate lipid metabolism and support positive changes in lean mass.
FIELD: process engineering. ^ SUBSTANCE: invention relates to medicine and food industry. Pericarpous fruits are finely crushed in roll grinder with distance between rolls of 7-8 mm, roll diametre of 150-250 mm, roll length of 500-700, and rpm of 50-100 min-1. Then, target product is separated with the help of purifier. ^ EFFECT: powder suitable for tabletting without additional treatment, stability in storage. ^ 4 cl
The WREX (Wilmington Robotic EXoskeleton) is being used by many children with neuromuscular conditions such as arthrogryposis and muscular dystrophy. Nemours/A.I. duPont Hospital for Children alone has provided a WREX for about 80 children in the last 3 years. This is being done through the orthopedic and muscle clinics in the hospital. We would like to perform a retrospective study to see how well the children are doing with the WREX. We propose getting this feedback through a survey administered to families using the WREX. The survey will be performed in two parts. 1) A phone survey will use the Canadian Occupational Performance Measure (COPM). 2) an online survey with additional questions. The parents are asked to submit answers on behalf of the children if they are unable to.
Relates to a microporous film for use on the surface of the skin. The microporous film is used for covering the surface of skin, the main component is one of medical polytetrafluoroethylene, medical silica gel and medical polyurethane, and the additive components are cosmetic components and skin care components for covering, whitening and the like, and medical components with conductive, piezoelectric or electrooptical characteristics. The microporous film is prepared by stretching in two directions or in one direction at high temperature, and cooling and forming. After molding, the adhesive layer can be compounded under the condition of low air permeability requirement, so that the attaching degree of the skin is increased. The microporous film has air permeability, can naturally cover wrinkles, scars, moles, acne, skin color deficiency and the like on the surface of the skin, and has a beautifying effect. Especially, the product containing polytetrafluoroethylene component can exert the performance advantages of sun protection, sulfuric acid resistance and the like of the material. The manufacturing process is mature, the manufacturing cost is low, and the method has wide application prospects in the fields of makeup, beauty, intelligent wearing and the like.
The genotype-phenotype relationship in PWS patients is important for a better understanding of the clinical phenotype and clinical characteristics of different genotypes of PWS in children. We aimed to explore the influence of specific gene changes on the clinical symptoms of PWS and the value of early screening and early intervention of the condition. All data in this study were extracted from the database of the XiaoPang Weili Rare Disease Care Center. The collected information included basic demographics, maternal pregnancy information, endocrine abnormalities, growth and development abnormalities, and other clinical phenotypes. The relationships between genotypes and phenotypes in the major categories of PWS were analyzed. A total of 586 PWS cases with confirmed molecular diagnosis and genotyping were included in this study. Among them, 83.8% belonged to the deletion type, 10.9% the uniparental disomy (UPD) type, and 5.3% the imprinting defect (ID) type. Age-wide comparison among the three groups: The rate of hypopigmentation in the deletion group was higher than that in the UPD group (88.8% vs. 60.9%; p < 0.05); A total of 62 patients (14.2%) had epilepsy; and no statistical significance was found among the three groups (p = 0.110). Age-wide comparison between the deletion and non-deletion types: the rate of skin hypopigmentation and epilepsy in the deletion group was significantly higher than that in the non-deletion group (88.8% vs. 68.4%, p < 0.001; 15.9% vs. 7.6%, p = 0.040). The intergroup comparison for the >2-year age group: there were significant intergroup differences in the language development delay among the three groups (p < 0.001). The incidence of delayed language development was the highest in the deletion group, followed by the UPD group, and the lowest in the ID group. The rates of obesity and hyperphagia in the deletion group were also higher than those in the non-deletion group (71.1% vs. 58.9%, p = 0.041; 75.7% vs. 62.0%, p = 0.016). There are significant differences in the rates of skin hypopigmentation and language developmental delay among the deletion, UPD, and ID genotypes. The patients with deletion type had significantly higher rates of lighter skin color, obesity, hyperphagia, language developmental delay, and epilepsy. The results of this study will help clinicians better understand the impact of different PWS molecular etiologies on specific phenotypes.
The invention belongs to the technical field of traditional Chinese medicines and relates to an oil-free donkey-hide gelatin and a preparation method thereof. The oil-free donkey-hide gelatin is prepared from the raw materials in parts by weight: 400-600 parts of donkey skin, 3-5 parts of yellow wine, 7-9 parts of rock candy, 2-4 parts of anise and 4-6 parts of radix angelicae. The preparation method comprises the following steps: (1) preparing the raw materials; (2) soaking, slicing and washing the donkey skins; (3) blanching and melting the donkey skins; (4) processing the gelatin juice; (5) concentrating. The donkey-hide gelatin prepared by the method is free of soya-bean oil, so that the problems of rancidity and foreign odor of the conventional donkey-hide gelatin added with the soya-bean oil can be solved, and the donkey-hide gelatin is healthier. In addition, the preparation method has the advantages of omitting the tedious operation of removing the hairs in the conventional preparing technology for donkey-hide gelatin, simplifying the processing technology and improving the yield of donkey-hide gelatin. The donkey-hide gelatin prepared by the method is mellow in taste, bright in cross section, warm and humid like a jade and good in water solubility, so that the quality of the donkey-hide gelatin is improved.