anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Pregnancy Category D 

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue trandolapril as soon as possible. These adverse outcomes are usually associated with use of these drugs in the second and third trimester of pregnancy. Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. Appropriate management of maternal hypertension during pregnancy is important to optimize outcomes for both mother and fetus. 

In the unusual case that there is no appropriate alternative to therapy with drugs affecting the renin-angiotensin system for a particular patient, apprise the mother of the potential risk to the fetus. Perform serial ultrasound examinations to assess the intra-amniotic environment. If oligohydramnios is observed, discontinue trandolapril, unless it is considered lifesaving for the mother. Fetal testing may be appropriate, based on the week of pregnancy. Patients and physicians should be aware, however, that oligohydramnios may not appear until after the fetus has sustained irreversible injury. Closely observe infants with histories of in utero exposure to trandolapril for hypotension, oliguria, and hyperkalemia (see PRECAUTIONS, Pediatric Use).

Doses of 0.8 mg/kg/day (9.4 mg/m2/day) in rabbits, 1000 mg/kg/day (7000 mg/m2/day) in rats, and 25 mg/kg/day (295 mg/m2/day) in cynomolgus monkeys did not produce teratogenic effects. These doses represent 10 and 3 times (rabbits), 1250 and 2564 times (rats), and 312 and 108 times (monkeys) the maximum projected human dose of 4 mg based on body-weight and body-surface-area, respectively assuming a 50 kg woman.
A perpetual bioinformatics and virtual colorimeter expert system platform is disclosed to remotely measure dermal and epidermal properties with precision and to enhance decision-making. Some embodiments of the system provide for virtual tristimulus colorimetry, wherein a capture device captures one or more dermal images of one or more skin area of a user. A color grid includes one or more permutations of a plurality of recorded predetermined colors. A scale of the color grid is recorded as being printed or projected at a predetermined size. Application of the virtual tristimulus colorimeter to one of the images is performed. As a result of this application the image is calibrated according to the virtual tristimulus colorimeter. In some embodiments the capture device may include a smartphone camera, interactive with the virtual tristimulus colorimeter smartphone application.
Placebo will be 0.1 ml sterile 0.9 % NaCl, which has a similar color as the resuspended BCG vaccine. Two placebo doses will be given, 4 weeks apart.
The invention discloses a creatine phosphate sodium oral solid preparation and a preparation method thereof, relating to an oral solid preparation and a preparation method thereof. The invention solves the problem that the existing pharmaceutical factories can not produce the creatine phosphate sodium oral solid preparation at home and abroad. The creatine phosphate sodium oral solid preparation consists of creatine phosphate sodium, starch, carboxymethyl starch sodium, microcrystalline cellulose and absorbefacient. The method comprises the steps of: weighing raw materials, drying and screening, mixing and filling to obtain an enteric capsule. The creatine phosphate sodium oral solid preparation consists of creatine phosphate sodium, absorbefacient, microcrystalline cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose solution, magnesium stearate, acrylic resin II, ethanol, twain-80, castor oil and phthalic acid diethyl ester. The method comprises the steps of: weighing raw materials, screening, preparing wet granule, tabletting, spraying casing liquid to obtain an enteric coated tablet. The invention realizes the preparation of the creatine phosphate sodium oral solid preparation, and can protect cardiac muscle and skeletal muscle.
The present application provides a health management method, a related apparatus, and a communication system. The method is constructed on the basis of a data bank. The process of processing user data in the data bank may comprise the collection, processing, opening, and value presentation of the user data. In the method, an electronic device can use user data to provide a user with a triage number appointment scheme and health management advice after clinic visiting such as medication reminders, diet advice, exercise advice, and shopping advice. The electronic device can also recommend the health management advice to an electronic device located in the same family group as the electronic device. The electronic device can further receive diagnostic results of family members of the user, and provide schemes to monitor the health status of the family members. In addition, the electronic device can also provide the user with usage advice of the electronic device according to the physical condition of the user. The method can help users manage their own and their family's health.
The method of cancer screening allows for a safe, reliable, inexpensive and minimally invasive diagnosis. Cells are first collected through non-invasive or minimally invasive means. The collected cells are stored in a cell culture media to keep them viable. A chemical compound such as 5-ALA is introduced to the cultured cells.  The cells are incubated a period of time in order for the interaction to occur between the introduced chemical compound and the collected cells. The cells are then studied under a fluorescence microscope which emits a specific frequency of light which matches the excitation frequency of light which would be emitted by abnormal cells. Pre-malignant and malignant cells will fluoresce in response to the interaction with the introduced compound and the specific frequency of light, while normal healthy cells generally will not fluoresce. If necessary, the collected cells may be passed through a flow cytometer to more easily identify the fluorescing cells. A presumptive diagnosis as to cancer may be made based upon the presence or absence of fluorescing cells. If a cell sample is adequately concentrated, a cell sorter does not need to be used and the cell sample may simply be viewed under the fluorescence microscope. Specific techniques are disclosed for non-invasive cell collection and minimally invasive collection. Each of these techniques minimize patient trauma and do not call for any type of incision for forced tissue removal as occurs in traditional biopsy procedures.
Visual predictive checks (VPC) are commonly used to evaluate pharmacometrics models. However their performance may be hampered if patients with worse outcomes drop out earlier, as often occurs in clinical trials, especially in oncology. While methods accounting for dropouts have appeared in literature, they vary in assumptions, flexibility, and performance, and the differences between them are not widely understood. This manuscript aims to elucidate which methods can be used to handle VPC with dropout and when, along with a more informative VPC approach using confidence intervals. Additionally, we propose constructing the confidence interval based on the observed data instead of the simulated data. The theoretical framework for incorporating dropout in VPCs is developed and applied to propose two approaches: full and conditional. The full approach is implemented using a parametric time-to-event model, while the conditional approach is implemented using both parametric and Cox proportional-hazard (CPH) models. The practical performances of these approaches are illustrated with an application to the tumor growth dynamics (TGD) modeling of data from two cancer clinical trials of nivolumab and docetaxel, where patients were followed until disease progression. The dataset consisted of 3504 tumor size measurements from 855 subjects, which were described by a TGD model. The dropout of subjects was described by a Weibull or CPH model. Simulated datasets were also used to further illustrate the properties of the VPC methods. The results showed that the more familiar full approach might not provide meaningful improvement for TGD model evaluation over the naive approach of not adjusting for dropout, and could be outperformed by the conditional approach using either the Weibull model or the Cox proportional hazard model. Overall, including confidence intervals in VPC should improve interpretation, the conditional approach was shown to be more generally applicable when dropout occurs, and the nonparametric approach could provide additional robustness.
PURPOSE: A pharmaceutical composition for treating and preventing convulsive disorder containing artemisiae capillaris herba extracts is provided to be safe for human body and to reduce side effects even when the composition is excessively used. CONSTITUTION: A pharmaceutical composition for treating and preventing convulsive disorder contains artemisiae capillaris herba extracts. A pharmaceutical composition for alleviating and preventing spasmolysis includes the artemisiae capillaris herba extracts. The artemisiae capillaris herba extract is extracted by using 60-80% of ethanol as an active ingredient. The artemisiae capillaris herba extracts include capillarisin or esculetin as the active ingredient. The convulsive disorder is non-traumatic stroma depression, anxiety disorders or psychosis failure. The convulsive disorder is a disease which can be treated or prevented according to the increase of Cl- inflow in cells. The convulsive disorder is prevented or treated by control of gamma-amino butyric acid receptor. [Reference numerals] (AA) The first group (con.); (BB) The second group (practical example 1, 50mg/kg); (CC) The third group (practical example 1, 100mg/kg); (DD) The fourth group (practical example 1, 200mg/kg); (EE) The fifth group (DZP, 5mg/kg); (FF) Tonic extension reaction(%); (GG) Current (mA)
FIELD: genetic engineering, immunology, molecular biology, pharmacy. SUBSTANCE: DNA structures involve genes encoding human influenza virus proteins: nucleoprotein, hemaglutinin, matrix protein. Vector V1Jns is used as structure base involving cytomegalovirus promoter with intron A sequence, transcription termination region of bovine growth hormone with fused unique site Sfi I, region of replication onset and kanamycin resistance gene. In administration in subject tissues DNA structures as components of immunogenic composition or vaccine express gene products of influenza virus that can provide immune protection from infection with homologous or heterogeneous strains of influenza virus. Invention ensures to provide a long time acting cross-reactive immunity against influenza virus and can be used in preparing pharmaceutical preparations providing immune protection against influenza virus. EFFECT: improved method of induction and vaccination, valuable medicinal properties. 8 cl, 51 dwg, 7 tbl, 15 ex
Single subject pretest-posttest design was used. 12 SCD subjects was recruited from the memory clinic and 12 healthy controls from the community. The anxiety level was assessed both by self-reports (State-Trait Anxiety Inventory and Visual Analogue Scale of Anxiety) and by objective measurements related to autonomic nervous system activities (heart rate variability and electrodermal activity). The participants underwent a memory task to induce anxiety. Next, preferred music and white noise were provided in random order. The anxiety level and the effects of music intervention between SCD and healthy controls will be further compared.
PURPOSE: Pancreatoduodenectomy (PD) is a highly invasive procedure. Intra-abdominal infections and pancreatic fistulas are strongly correlated complications. In the present study, we identified the risk factors for postoperative early drain colonization (POEDC) and established a perioperative management strategy.
METHODS: A total of 205 patients who underwent pancreatoduodenectomy were included in the study. POEDC was defined as a positive drain fluid culture before postoperative day (POD) 4. We retrospectively investigated the correlation between POEDC, postoperative outcomes, and clinical factors.
RESULTS: POEDC was observed in 26 patients (12.6%) with poor postoperative outcomes, including pancreatic fistulas (P < 0.001). A multivariate analysis demonstrated a correlation between these postoperative outcomes and the age (P = 0.002), body mass index (BMI) (P = 0.002), procalcitonin (PCT) level (P < 0.001), and drain amylase level on POD 1 (P = 0.032). Enterococcus was detected most frequently, being found in 15 patients.
CONCLUSION: We observed a strong correlation between POEDC and poor postoperative outcomes. The BMI, age, and PCT and drain amylase level on POD 1 should be considered POEDC risk factors, with the need to propose an antibiotic perioperative strategy. POEDC control may represent the key to improving postoperative outcomes after PD.
Store between 20ºC to 25ºC (68ºF to 77ºF); excursions permitted between 15ºC and 30ºC (between 59ºF and 86ºF) [See USP Controlled Room Temperature]. Not made with natural rubber latex. Keep from freezing. Protect from light. 

After the ATROPEN autoinjector has been activated, the empty container should be disposed of properly. It cannot be refilled, nor can the protruding needle be retracted.
OBJECTIVE: Reporting clinical outcomes of acute type A aortic dissection.
METHODS: Data derived from the survey of the Japanese Association for Thoracic Surgery, the Japan Cardiovascular Database, and the Japanese Registry of All Cardiac and Vascular Diseases were analyzed.
RESULTS: Between 2012 and 2015, the Japanese Registry of All Cardiac and Vascular Diseases study collected 13,131 patients and the hospital mortality was 24.3%. The surgical mortality was significantly lower than medical one (11.8% vs 49.7%; p < 0.001). The Japanese Association for Thoracic Surgery survey disclosed the number of surgeries has been increased to 6157 in 2018 and the hospital death has decreased to 10.5%. The Japan Cardiovascular Database, collected 29,486 patients from 2013 to 2018. Age at surgery was 59.8  ±  14.2 years and patients younger than 65 years in 61% and 21% were older than 75 years. Ninety-four percent had surgery within 24 h after diagnosis. Antegrade cerebral perfusion was used in 74% and deep hypothermic circulatory arrest with/without retrograde cerebral perfusion in 26%. Replacement of the ascending aorta was performed in 62% and total arch replacement in 28%. The aortic valve was replaced in 7.9% and repaired in 4.4%. The hospital mortality was 11%. New stroke occurred in 12%, hemodialysis in 7.3%, paraplegia in 3.9%, and prolonged ventilation in 15%.
CONCLUSION: The number of operations for type A aortic dissection has increased, and hospital mortality has improved. Although the early results after surgery for type A aortic dissection are acceptable, new strategies to improve early outcomes in patients with preoperative comorbidities are required.
Ketorolac has analgesic, anti-inflammatory, and antipyretic properties. 

The mechanism of action of SPRIX, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2), an early component of the arachidonic acid cascade, resulting in the reduced synthesis of prostaglandins, thromboxanes, and prostacyclin.

Ketorolac is a potent inhibitor of prostaglandin synthesis in vitro. Ketorolac concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because ketorolac is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Aberrant upregulation of Periostin (POSTN) expression has been implicated in various disease-related pathological cascades, notably inflammatory responses, fibrotic processes and tumor progression, including non-small cell lung cancer (NSCLC). The present study aimed to elucidate the functional role and underlying mechanisms of POSTN in NSCLC. Immunohistochemical and Western blot analysis consistently revealed elevated POSTN levels in NSCLC tissues and cell lines. POSTN expression negatively correlated with patient prognosis. Functional experiments utilizing POSTN-targeting siRNAs demonstrated a significant suppression of NSCLC cell proliferation, epithelial-to-mesenchymal transition (EMT), migration and invasion, whereas POSTN overexpression via plasmid transfection enhanced these oncogenic properties. Mechanistically, RNA sequencing analysis and subsequent validation studies revealed that POSTN positively modulates the transcriptional expression of tumor necrosis factor alpha-induced protein 6 (TNFAIP6) in NSCLC. Notably, a positive correlation was observed between POSTN and TNFAIP6 expression levels, and their overexpression positively correlated with NSCLC progression. Furthermore, TNFAIP6 overexpression rescued the inhibitory effects of POSTN knockdown on NSCLC malignant phenotypes. Collectively, our findings indicate that POSTN promotes NSCLC malignancy through TNFAIP6 upregulation, positioning POSTN as a promising biomarker and potential therapeutic target for NSCLC prognosis and treatment strategies in clinical settings.
HIV-positives will receive prevention with positives (PwP) counseling and point of care CD4 counts. Those with CD4 \<500/μL will be assigned a peer case manager to link the person to ART at study-participating HIV clinics, support ART and PwP adherence and care retention. Confirmed HCV viremic will receive HCV treatment.
Pregnancy with major fetal congenital heart disease, after 20 weeks gestation, and as neonate following delivery. Two fetal magnetocardiograms (fMCG) and 1 neonatal electrocardiogram (nECG) will be obtained and heart rate, rhythm, and conduction patterns will be compared.
When post partum hemorrhage occurs one mode of therapy is to place a balloon tamponade catheter into the uterus to compress the bleeding vessels. When this mode of therapy has been chosen by the attending physician the patient will be randomized to either the room temperature arm (control) or the cold arm (study). The balloon catheter is placed through the vagina into the uterus and inflated using normal saline; room temperature for the control group and approximately 32 degrees F for the study group. Traction is placed on the catheter to tamponade the vessels in the lower uterine segment. Blood from the uterus passes through a central lumen of the balloon and will be collected and measured. Total measured blood loss for each group will be compared.
Preparation of a composition (A) for preventing or curing diseases caused by a microorganism (B) that has, on the outer surface of the cell wall, motifs that interact, in a ligand-receptor fashion, with the mannose receptors of macrophages (MMR). The preparation uses at least one agonist ligand (I) for the nuclear receptor PPARgamma (peroxisome proliferator receptor gamma ). Independent claims are also included for the following: (1) method for extracorporeal treatment of a medium containing macrophages by adding (I) so as to induce and/or amplify expression of MMR; and (2) method for extracorporeal inhibition of proliferation of (B) by adding (I) to a medium infected by (B). ACTIVITY : Antibacterial; Fungicide; Protozoacide; Virucide; Anti-HIV; Immunostimulant. MECHANISM OF ACTION : Macrophage Stimulant. Immunodeficient mice (RAG-2) were treated daily (days 1-6) with 0.01 Micromole of 15d-PGJ2 by intraperitoneal injection and on day 2 infected with 10 7>colony-forming units of Candida albicansby oral gavage. Macrophages were recovered by washing the peritoneal cavity, cultured and tested for phagocytosis of C. albicansby measuring incorporation of tritiated uracil into fungal RNA. The mean index of phagocytosis was 76.32%; compared to 59.82% for animals not treated with 15d-PGJ2.
INTRODUCTION: Despite advancements, invasive fungal infections (IFI) still carry high mortality rates, often exceeding 30%. The challenges in diagnosis, coupled with limited effective antifungal options, make managing IFIs complex. Antifungal drugs are essential for IFI management, but their efficacy can be diminished by drug-drug interactions and pharmacokinetic variability. Therapeutic Drug Monitoring (TDM), especially in the context of triazole use, has emerged as a valuable strategy to optimize antifungal therapy.
AREAS COVERED: This review provides current evidence regarding the potential benefits of TDM in IFI management. It discusses how TDM can enhance treatment response, safety, and address altered pharmacokinetics in specific patient populations.
EXPERT OPINION: TDM plays a crucial role in achieving optimal therapeutic outcomes in IFI management, particularly for certain antifungal agents. Preclinical studies consistently show a link between therapeutic drug levels and antifungal efficacy. However, clinical research in mycology faces challenges due to patient heterogeneity and the diversity of fungal infections. TDM's potential advantages in guiding Echinocandin therapy for critically ill patients warrant further investigation. Additionally, for drugs like Posaconazole, assessing whether serum levels or alternative markers like saliva offer the best measure of efficacy is an intriguing question.
Drought is a major adverse environmental factor that plants face in nature but the molecular mechanism by which plants transduce stress signals and further endow themselves with tolerance remains unclear. Malectin/malectin-like domains containing receptor-like kinases (MRLKs) have been proposed to act as receptors in multiple biological signaling pathways, but limited studies show their roles in drought-stress signaling and tolerance. In this study, we demonstrate OsMRLK63 in rice (Oryza sativa L.) functions in drought tolerance by acting as the receptor of 2 rapid alkalization factors, OsRALF45 and OsRALF46. We show OsMRLK63 is a typical receptor-like kinase that positively regulates drought tolerance and reactive oxygen species (ROS) production. OsMRLK63 interacts with and phosphorylates several nicotinamide adenine dinucleotide phosphate (NADPH) oxidases with the primarily phosphorylated site at Ser26 in the N-terminal of RESPIRATORY BURST OXIDASE HOMOLOGUE A (OsRbohA). The application of the 2 small signal peptides (OsRALF45/46) on rice can greatly alleviate the dehydration of plants induced by mimic drought. This function depends on the existence of OsMRLK63 and the NADPH oxidase-dependent ROS production. The 2 RALFs interact with OsMRLK63 by binding to its extracellular domain, suggesting they may act as drought/dehydration signal sensors for the OsMRLK63-mediated process. Our study reveals a OsRALF45/46-OsMRLK63-OsRbohs module which contributes to drought-stress signaling and tolerance in rice.
Three lens care systems randomly assigned. Contact lenses were pre-soaked overnight prior to insertion, then worn for 8 hours, with a minimum two-day washout between each wear period.