anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a traditional Chinese medicine composition having the functions of tonifying spleen and qi, as well as a preparation method and an application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following active ingredients according to parts by weight: 7-13 parts of ginseng, 7-13 parts of rhizoma atractylodis macrocephalae, 7-13 parts of poria cocos, 7-13 parts of liquorice, 7-13 parts of amomum kravanh, 7-13 parts of rhizoma cyperi, 7-13 parts of dried ginger, 7-13 parts of hawthorn, 7-13 parts of mangnolia officinalis, 7-13 parts of eupatorium, 7-13 parts of fructus amomi, 7-13 parts of coptis chinensis, and 7-13 parts of clove. The traditional Chinese medicine composition having the functions of tonifying spleen and qi has the effects of resolving dampness, promoting the circulation of qi, warming the middle-jiao, strengthening the spleen, warming the stomach, promoting digestion, eliminating dampness, promoting urination and eliminating cold to stop pain. Clinical verification shows that a user does not have drug dependence, and the traditional Chinese medicine composition has the advantages of good curative effect, safety and stability. The preparation process is simple, safe and sanitary. A massage cream prepared from the traditional Chinese medicine composition having the functions of tonifying spleen and qi and a matrix or a carrier is convenient to use, has a good curative effect, is safe and stable, is mild and non-irritant to the skin, and has no toxic or side effects.
The therapies will be performed by one a physical therapist with experience in rehabilitation, twice a week, lasting 60 minutes, for one month. Each therapy will last 20 minutes.
REGAIN is a retrospective and prospective asthma cohort study designed to determine real-world molecular description of asthma according to treatment and type 2 biology. The researchers will enroll 5 pre-specified groups of participants with asthma of specific interest for mechanistic analyses according to clinically determined type 2 inflammatory endotype and response to therapy with inhaled steroids and other inhaled controllers with or without asthma biologics. This study is conducted at asthma specialty programs at Mount Sinai National Jewish Health Respiratory Institute in New York and National Jewish Health, Denver, Colorado, USA. Participants with asthma meeting specific inclusion criteria were identified and enrolled by screening electronic medical records from pulmonary and allergy specialty programs. Targeted populations included 5 categories of asthma patients as outlined in Table 1 including the following: (1) patients with type 2 asthma with symptom control at time of enrollment (ACT \> 20) on standard Global Initiative For Asthma (GINA) step therapy (n=200) (2) asthma managed on stable biological therapy (n=200), (3) type 2 asthma with prior treatment with at least 2 biological therapies, (n=60), (4) likely type 2 low asthma patients (n=200), (5) asthma patients scheduled to be started de novo on biological therapies (n=120), and (6) healthy participants (n=400). Healthy participants were recruited in New York and Denver by community advertising. An optional study component employing a mobile phone application, use of digital inhaler monitors, and home digital peak flow will contribute data regarding medication use and lung function in the community and collect environmental data impacting asthma using geolocation data.
BACKGROUND: Although blood eosinophil count is recognized as a useful biomarker for the management of chronic obstructive pulmonary disease (COPD), the impact of eosinophils in COPD has not been fully elucidated. Here we aimed to investigate the relationships between the blood eosinophil count and various clinical parameters including lung structural changes.
METHODS: Ninety-three COPD patients without concomitant asthma were prospectively enrolled in this study. Blood eosinophil count, serum IgE level, serum periostin level, and chest computed tomography (CT) scans were evaluated. Eosinophilic COPD was defined as COPD with a blood eosinophil count ≧ 300/µL. We examined the correlation between the blood eosinophil count and structural changes graded by chest CT, focusing specifically on thin airway wall (WT thin) and thick airway wall (WT thick) groups. In a separate cohort, the number of eosinophils in the peripheral lungs of COPD patients with low attenuation area (LAA) on chest CT was assessed using lung resection specimens.
RESULTS: The mean blood eosinophil count was 212.1/µL, and 18 patients (19.3%) were categorized as having eosinophilic COPD. In the whole group analysis, the blood eosinophil count correlated only with blood white blood cells, blood basophils, C-reactive protein level, and sputum eosinophils. However, the blood eosinophil count positively correlated with the percentage of LAA and negatively correlated with the diffusing capacity for carbon monoxide in the WT thin group. Lung specimen data showed an increased number of eosinophils in the peripheral lungs of COPD patients with LAA on chest CT scans compared to normal controls.
CONCLUSIONS: Some COPD patients without concomitant asthma showed a phenotype of high blood eosinophils. Alveolar damage may be related to eosinophilic inflammation in patients with COPD without asthma and thickening of the central airway wall.
1,204,173. Contraceptive compositions. H. SMITH. 11 Sept., 1967, No. 11132/70. Divided out of 1,204,171. Heading A5B. Contraceptive compositions comprise 13- ethyl-17α-chloroethynyl-17#-hydroxygon- 4-en -3-one as anti-fertility agent in association with a pharmaceutically acceptable carrier (a) in an amount of from 5 to 90 micrograms formulated for daily administration and release in one day or (b) formulated as a delayed release composition for administration less frequently than daily comprising an amount of from 5 to 150 micrograms multiplied by the number of days over which it is to be released. The anti-fertility agent may be present as the racemate or d-enantiomer. The composition may be administered orally, parenterally or rectally in the form of tablets, capsules, powders, dispersible granules, cachets, solutions, suspensions, emulsions, vials, ampoules, suppositories or a delayed release composition, such as an implant, containing a plastic or a modified carboxymethyl-cellulose.
Interpret DATSCAN images visually, based upon the appearance of the striata. Reconstructed pixel size should be between 3.5 mm and 4.5 mm with slices 1 pixel thick. Optimum presentation of the reconstructed images for visual interpretation is transaxial slices parallel to the anterior commissure-posterior commissure (AC-PC) line. 

Determine whether an image is normal or abnormal by assessing the extent (as indicated by shape) and intensity of the striatal signal. Image interpretation does not involve integration of the striatal image appearance with clinical signs and/or symptoms.

Normal: In transaxial images, normal images are characterized by two symmetric comma- or crescent-shaped focal regions of activity mirrored about the median plane. Striatal activity is distinct, relative to surrounding brain tissue (Figure 1). 

Abnormal: Abnormal DATSCAN images fall into at least one of the following three categories (all are considered abnormal).

  * Activity is asymmetric, e.g., activity in the region of the putamen of one hemisphere is absent or greatly reduced with respect to the other. Activity is still visible in the caudate nuclei of both hemispheres resulting in a comma or crescent shape in one and a circular or oval focus in the other. There may be reduced activity between at least one striatum and surrounding tissues (Figure 2).
  * Activity is absent in the putamen of both hemispheres and confined to the caudate nuclei. Activity is relatively symmetric and forms two roughly circular or oval foci. Activity of one or both is generally reduced (Figure 3).
  * Activity is absent in the putamen of both hemispheres and greatly reduced in one or both caudate nuclei. Activity of the striata with respect to the background is reduced (Figure 4).
The invention relates to an external washing medicine for treating knee osteoarthritis. The external washing medicine is composed of the following traditional Chinese medicines: common clubmoss herb, fructus liquidambaris, safflower, radix aconiti preparata, prepared kusnezoff monkshood root, Smilax glabra, speranskia herb, tarragon, clematis root, radix angelicae dahuricae, rhizoma corydalis, seed powder of Chinese prickly ash, fructus evodiae powder and asarum herb. After detection of the above traditional Chinese medicines, hot gas is used for fumigating and a liquid medicine is used for embathing. The external washing medicine have effects of invigorate blood circulation and dispelling cold, relaxing vein and relieving pain, expanding blood vessel, promoting blood circulation, restraining and sterilizing bacteria, eliminating inflammation and the like. The external washing medicine guides drugs to illness station, has no defects of oral medicines, is simple and practical and yields twice the result with half the effort. By the use of the external washing medicine, good curative effects can be achieved.
The medicamentous form, in particular film-tablets comprises potassium DL-aspartate and magnesium-bis-DL-aspartate as an active substance. It is applied in human medicine for the treatment of cardiac insufficiency, angina pectoris, cardiac infarction. The film-tablets have excellent mechanical strength. They contain a nucleus comprising of potassium DL-aspartate, optionally in microcapsulated form, magnesium-bis-DL-aspartate, microcrystalline cellulose, polyvinyl pyrrolidone, Na-carboxymethyl starch, colloid silicon dioxide, magnesium stearate and film coating comprising polyvinyl alcohol, titanium dioxide, purified talcum powder, lecithin and xanthane rubber. By the method granules are prepared of magnesium-bis-DL-aspartate-4H2) and microcrystalline cellulose, they are wetted with polyvinyl pyrrolidone and ethyl alcohol, and are then mixed with potassium DL-sspartatee.1/2H2), the residue of the calculated quantity of microcrystalline cellulose, N-carboxymethyl starch, magnesium stearate and colloid silicon dioxide. The substance produced in subjected to tabletting. The tablets are coated with a mixture of polyvinyl alcohol, titanium dioxide, purified talcum powder, lecithin and xantane rubber. 4 claims
<P>PROBLEM TO BE SOLVED: To provide meat and eggs of birds which is easily and effectively improved in taste.  <P>SOLUTION: Drinking water for birds which is from a Gramineae plant contains 0.00001-30 wt.% of extracted components of the Gramineae plant based on the whole drinking water. The Gramineae plant is Gramineae, Bambusaceae plant which is the genus Sasa. The extracted components are obtained by steaming leaves and/or culms of Gramineae plant and extracting the components with an aqueous solvent. The steaming comprises steaming the leaves and/or culms of the Gramineae plant at 120-250°C for 30 s - 1 h with dry steam having improved dryness by a reducing valve and a gas-liquid separator.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Traditional endoscopic sclerotherapy for internal hemorrhoids require retroflection of the endoscope. Retroflection of the endoscope has blind areas and affects the precise operation. And, short-needle injection can easily lead to artificial ulcer and secondary bleeding. CAES is a new, minimally invasive endoscopic technique for the treatment of internal hemorrhoids and rectal prolapse. CAES was performed based on the requirement of the cap, endoscope, disposable endoscopic long injection needle, enough insufflated air and sclerosing agent. It can accurately control the injection angle, direction and depth under direct vision, and avoid iatrogenic injury caused by ectopic injection to the greatest possible extent. To investigate the effect of long needle and short needle on the outcome of CAES, participants with internal hemorrhoids and rectal prolapse were randomly assigned to a long needle group and a short needle group using a prospective, randomized, controlled study at multiple centers in China. The efficacy, adverse events and satisfaction of the two groups were observed.
Rivaroxaban was not carcinogenic when administered by oral gavage to mice or rats for up to 2 years. The systemic exposures (AUCs) of unbound rivaroxaban in male and female mice at the highest dose tested (60 mg/kg/day) were 1- and 2-times, respectively, the human exposure of unbound drug at the human dose of 20 mg/day. Systemic exposures of unbound drug in male and female rats at the highest dose tested (60 mg/kg/day) were 2- and 4-times, respectively, the human exposure.

Rivaroxaban was not mutagenic in bacteria (Ames-Test) or clastogenic in V79 Chinese hamster lung cells in vitro or in the mouse micronucleus test in vivo. 

No impairment of fertility was observed in male or female rats when given up to 200 mg/kg/day of rivaroxaban orally. This dose resulted in exposure levels, based on the unbound AUC, at least 13 times the exposure in humans given 20 mg rivaroxaban daily.
An emerging body of research utilizes music in the treatment of children with specific learning disorders in reading. However, greater understanding of music interventions is necessary for efficient application of music to address children's specific reading needs. Therefore, this scoping review aimed to identify the key musical concepts used to improve reading skills. Intervention studies were identified through online searches of databases and hand searching of primary journals in music therapy, and 12 studies met the inclusion criteria. For the 12 studies, auditory processing, phonological processing, and temporal processing were the underlying mechanisms identified in the interventions. Most of the interventions presented rhythmic activities for the purpose of improving reading accuracy. The results of this study highlight the lack of specific descriptions for the musical elements used within music interventions targeting reading skills. In addition, due to the diversity of the terms used to describe the music interventions, it was difficult to compare the effectiveness of these interventions on reading accuracy, comprehension skills, and fluency. Therefore, future studies are needed to articulate clear rationales for how musical elements can be used in music interventions to treat specific reading disabilities in children.
Drugs that are freely or highly soluble in water are formulated as unit dosa ge forms by incorporating them into polymeric matrices comprised of high molecular weight hydrophilic polymers that swell upon imbibition of water. The dosage form can be a single compressed tablets, or two or three compressed tablets retained in a single gelatin capsule. The oral formulation is designed for gastric retention and controlled delivery of an incorporated drug into the gastric cavity, and thu s administered, the drug is released from the matrix into the gastric fluid by solution diffusion. The swollen polymeric matrix, having achieved sufficient size, remains in the gastric cavity for several hours if administered while the patient is in the fed mode, and remains inta ct long enough for substantially all of the drug to be released before substantial erosion of the matrix occurs. The swelling matrix lowers the accessibility of the gastric fluid to the drug and thereby limits the drug release rate. This process, together with diffusion retardation by selection of specific polymers, polymer molecular weights, and other variables, results in a sustained and controlled delivery rate of the drug to the gastric environment.
PURPOSE: To evaluate the feasibility and utility of a deep learning (DL)-based reconstruction for improving the SNR of hyperpolarized 129Xe lung ventilation MRI.
METHODS: 129Xe lung ventilation MRI data acquired from patients with asthma and/or chronic obstructive pulmonary disease (COPD) were retrospectively reconstructed with a commercial DL reconstruction pipeline at five different denoising levels. Quantitative imaging metrics of lung ventilation including ventilation defect percentage (VDP) and ventilation heterogeneity index (VHI) were compared between each set of DL-reconstructed images and alternative denoising strategies including: filtering, total variation denoising and higher-order singular value decomposition. Structural similarity between the denoised and original images was assessed. In a prospective study, the feasibility of using SNR gains from DL reconstruction to allow natural-abundance xenon MRI was evaluated in healthy volunteers.
RESULTS: 129Xe ventilation image SNR was improved with DL reconstruction when compared with conventionally reconstructed images. In patients with asthma and/or COPD, DL-reconstructed images exhibited a slight positive bias in ventilation defect percentage (1.3% at 75% denoising) and ventilation heterogeneity index (˜1.4) when compared with conventionally reconstructed images. Additionally, DL-reconstructed images preserved structural similarity more effectively than data denoised using alternative approaches. DL reconstruction greatly improved image SNR (greater than threefold), to a level that 129Xe ventilation imaging using natural-abundance xenon appears feasible.
CONCLUSION: DL-based image reconstruction significantly improves 129Xe ventilation image SNR, preserves structural similarity, and leads to a minor bias in ventilation metrics that can be attributed to differences in the image sharpness. This tool should help facilitate cost-effective 129Xe ventilation imaging with natural-abundance xenon in the future.
This review analyzes the published evidence regarding maternal factors that influence the developmental programming of long-term adiposity in humans and animals via the central nervous system (CNS). We describe the physiological outcomes of perinatal underfeeding and overfeeding and explore potential mechanisms that may mediate the impact of such exposures on the development of feeding circuits within the CNS-including the influences of metabolic hormones and epigenetic changes. The perinatal environment, reflective of maternal nutritional status, contributes to the programming of offspring adiposity. The in utero and early postnatal periods represent critically sensitive developmental windows during which the hormonal and metabolic milieu affects the maturation of the hypothalamus. Maternal hyperglycemia is associated with increased transfer of glucose to the fetus driving fetal hyperinsulinemia. Elevated fetal insulin causes increased adiposity and consequently higher fetal circulating leptin concentration. Mechanistic studies in animal models indicate important roles of leptin and insulin in central and peripheral programming of adiposity, and suggest that optimal concentrations of these hormones are critical during early life. Additionally, the environmental milieu during development may be conveyed to progeny through epigenetic marks and these can potentially be vertically transmitted to subsequent generations. Thus, nutritional and metabolic/endocrine signals during perinatal development can have lifelong (and possibly multigenerational) impacts on offspring body weight regulation.
This was the ePRO study group: A total of 50 patients were enrolled in this group. After receiving anti-tumor drug treatment, the ePRO system was installed through the mobile phone. After training, the patients could skillfully use the ePRO system.
A formulation for substituted 2-aminothiazoles in the prophylaxis and treatment of fungal and fungal-bacterial infections of the nail (onychomycosis) is disclosed. These formulations are particularly suitable for the topical application onto a nail. After evaporation of the solvent a thin polymer layer is formed on the nail from which the substituted 2-aminothiazole diffuses into the nail and the nail bed. A particularly effective substituted 2-aminothiazole is abafungin. The substituted 2-aminothiazoles are not only fungicidal, but also sporicidal and anti-bacterial. This is a novel approach to efficiently treat onychomycosis and to avoid frequent relapses of the infection.
Allii Macrostemonis Bulbus (AMB) is a traditional Chinese medicine with medicinal and food homology. AMB has various biological activities, including anti-coagulation, lipid-lowering, anti-tumor, and antioxidant effects. Saponins from Allium macrostemonis Bulbus (SAMB), the predominant beneficial compounds, also exhibited lipid-lowering and anti-inflammatory properties. However, the effect of SAMB on atherosclerosis and the underlying mechanisms are still unclear. This study aimed to elucidate the pharmacological impact of SAMB on atherosclerosis. In apolipoprotein E deficiency (ApoE-/-) mice with high-fat diet feeding, oral SAMB administration significantly attenuated inflammation and atherosclerosis plaque formation. The in vitro experiments demonstrated that SAMB effectively suppressed oxidized-LDL-induced foam cell formation by down-regulating CD36 expression, thereby inhibiting lipid endocytosis in bone marrow-derived macrophages. Additionally, SAMB effectively blocked LPS-induced inflammatory response in bone marrow-derived macrophages potentially through modulating the NF-κB/NLRP3 pathway. In conclusion, SAMB exhibits a potential anti-atherosclerotic effect by inhibiting macrophage foam cell formation and inflammation. These findings provide novel insights into potential preventive and therapeutic strategies for the clinical management of atherosclerosis.
HIV positives that have not successfully linked to care after the first randomization will be re-randomized to receive either an SMS message or economic incentive to link to care. (HIV Positive Cohort approximately N=108).
OBJECTIVE: To evaluate patient-reported quality of life (PRQoL) in patients presenting with membranous urethral stenosis after prostate radiotherapy. Urethral stenosis is an under-reported complication after prostate radiotherapy with a particular deficiency in PRQoL.
METHODS: Patients presenting with urethral stenosis after radiotherapy were retrospectively reviewed from 2004 to 2022. PRQoL was assessed via patient survey using the Expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP).
RESULTS: Two hundred thirty patients were identified at a mean age of 67.7years and mean time to stricture diagnosis of 63.6months' postradiotherapy. Of 87 patients completing the survey, 29.9% recalled being aware of urethral stenosis as a potential complication and 51.7% had documentation of urethral stenosis as a potential complication. 33.5% of patients underwent urethroplasty, 59.6% repeat endoscopic treatment and 6.1% an indwelling catheter. 64.4% of patients reported urinary dysfunction as a "moderate" or "big" problem, 66.7% reported frequent or total incontinence, 64.4% required daily pad use and 50.6% reported incontinence as either a "moderate" or "big" problem. 85.0% reported poor or absent orgasmic dysfunction and 88.5% reported erections insufficient for sexual activity. Additionally, 47.1% of patients reported rectal pain and 31.0% reported dysuria. Depressive symptoms and fatigue were reported by 41.4% and 60.9% of patients respectively.
CONCLUSION: Urethral stenosis after radiotherapy is a clinically complex entity with a broad scope of associated symptoms including high rates of patient-reported incontinence, voiding dysfunction, sexual dysfunction, pain, bowel dysfunction and depression. This multifocal nature combined with often insidious presentation and patient unawareness creates a uniquely challenging condition to treat.
TOBI™ Podhaler™ 112 mg inhaled by mouth twice daily for 30 days followed by a 30-day cycle colistimethate 75 mg inhaled two times daily. Repeat cycle.