anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Enrollees will include 300 nicotine dependent adolescents aged 16-25, who vape, do not smoke, and want to quit vaping. The study will will consist of a three-arm randomized, placebo-controlled, parallel-group study of (1) varenicline up to 1 mg bid for 12 weeks added to behavioral and texting support for adolescent vaping cessation or (2) behavioral and texting support and placebo or (3) monitoring only. The primary comparison of interest is efficacy of (1) varenicline vs (2) placebo arms on vaping abstinence outcomes. The study consists of one enrollment visit, one baseline visit, twelve weekly individual treatment and assessment sessions, and six monthly visits at weeks 4, 8, 12, 16, 20 and 24 weeks. At the enrollment visit, participants will complete interviews, questionnaires and diagnostic assessments, as well as saliva and urine sample and vitals. At the baseline visit, participants will complete several interviews, questionnaires, provide a saliva sample for cotinine measurement, and be randomized to the varenicline plus behavioral treatment group, the placebo plus behavioral treatment group, or monitoring-only group. Study staff will distribute varenicline or identically appearing placebo with instructions on how to take the study medication at weeks 0, 2, 4 and 8. Participants will be instructed to bring all empty and unused study medication at each in-person study visit through Week 12. At the weekly treatment meetings, participants will participate in cognitive behavioral therapy and complete questionnaires. Monthly visits will consist of interviews, questionnaires and a saliva and urine sample.
Patient death can be a stressful experience for nursing students, leading to various undesirable psychological and emotional effects. However, research documenting these experiences remains limited. This study explores the experiences of Iranian nursing students when facing patient death. This qualitative study employed a purposive sample of 14 undergraduate nursing students. Data was collected through semi-structured interviews and analyzed using conventional content analysis. Lincoln and Guba's (2004) criteria guided the data management process. Data analysis revealed three primary categories with six corresponding subcategories. These categories encompassed the significance of death, reactions to death, and the transformation of professional perspectives. Subcategories included positive and negative meanings attributed to death, emotional and behavioral responses, and the positive and negative effects on participants. The findings reveal that experiencing patient death significantly impacts nursing students psychologically and emotionally. Consequently, it is recommended that nursing curricula incorporate essential training modules addressing appropriate responses to death and effective communication with bereaved families. Further research should explore strategies to mitigate negative impacts and optimize positive outcomes related to this phenomenon.
Rifabutin is a red-violet powder souble in chloroform and methanol, sparingly souluble in ethanol, and very slightly soluble in water. Mycobutin capsules contain the antimycobacterial agent rifabutin, which is a semisynthetic ansamycin antibiotic derived from rifamycin S. Mycobutin capsules for oral administered contain 150mg of rifabutin, USP, per capsule, along with the inactive ingredients microcrystalline cellulose magenesium stearate, red iron oxide3, silica gel, sodium lauryl sulfate, titanium dioxide, and edible white ink.
The goal of this study is to determine the effects of message framing (gain vs. loss) on African American parents' acceptance of the HPV vaccine and how such effects are moderated by parents' salient beliefs prior to message exposure. Participants recruited from local communities and online panels will complete a computer-assisted survey. In the survey participants will first answer questions related to their beliefs about HPV and the HPV vaccine (e.g., perceived susceptibility, perceived severity, perceived efficacy, perceived safety, etc.), as well as other background information. Then they will be presented with either a gain-framed or loss-framed human papillomavirus vaccination message. After the message exposure, they will answer questions related to their attitudes toward HPV vaccination, intentions to vaccinate their children, as well as other message response measures. Eligible participants are at least 21 years old, self-identify as African American, and are custodial parents or caretakers of at least one child ages 9-17 who has not initiated the HPV vaccine series.
BACKGROUND: Physical fatigue is one of the most disabling symptoms in people with Multiple Sclerosis (PwMS). Several factors might influence the development of fatigue, such as gender, education, body mass index (BMI), Expanded Disability Status Scale (EDSS), disease duration, working status (Ws), physiotherapy (Ph), and disease-modifying therapies (DMTs). Fatigue Symptoms and Impacts Questionnaire-Relapsing Multiple Sclerosis (FSIQ-RMS) is a patient-reported outcome (PRO) that allows one to define the impact of fatigue in PwMS clearly. This study aimed to assess fatigue impact on PwMS by using FSIQ-RMS.
METHODS: The participants were enrolled from May to July 2021 in MS Centers of Sant'Andrea Hospital and Policlinico Umberto I Hospital in Rome. Fatigue was evaluated using the FSIQ-RMS, validated, and culturally adapted in Italian. Clinical and demographic data were collected at the same time.
RESULTS: We enrolled 178 PwMS [Female 74.16%; RMS 82.58%, SPMS 17.52%]. FSIQ-RMS scores were significantly correlated with EDSS (p-value < 0.01). Analysis of variance between means showed a statistically significant difference between the BMI groups at the 24hours_FSIQ-RMS score and the 7days_FSIQ-RMS score (p < 0.01), with the lower BMI group having the highest scores. Furthermore, perceived fatigue significantly improved both in subjects performing Ph (p < 0.05) and in those who actively work (p < 0.01).
CONCLUSIONS: The use of FSIQ-RMS in a real-world setting confirmed that underweight and high levels of disability are closely related to fatigue. In addition, Ph and active Ws are strongly correlated with fatigue in PwMS.
Rheumatic heart disease (RHD) in pregnancy can be associated with severe maternal and neonatal morbidity and mortality. Early identification of these women and referral to specialized, multi-disciplinary care is essential. Overall, studies on RHD prevalence are lacking in sub-Saharan countries and a significant gap in the literature exists for the prospective assessment of disease in the context of pregnancy. At Moi Teaching and Referral Hospital, there are an estimated 3-4 cases per month of women presenting with acute exacerbations of either known or newly diagnosed cardiac disease. These women are often the most challenging clinically and emotionally for the reproductive health team to manage, and contribute to a significant number of the 2-3 maternal deaths per month at MTRH. There is currently no routine screening for cardiac disease in the MTRH antenatal clinics. This study will aim to determine the point prevalence of cardiac disease in women presenting for antenatal care at Moi Teaching and Referral Hospital. More specifically, it will aim to: 1. Use focused echocardiography as a screening tool to evaluate cardiac structure and function; 2. Use focused echocardiography as a screening tool to determine the prevalence of cardiac disease among pregnant women attending MTRH antenatal clinic.; 3. Determine the proportion of pregnant women with cardiac disease who endorse clinical symptoms as a potential means to develop a screening tool; 4. Promote a case-finding culture for cardiac disease in pregnancy
The invention relates to a medium for the bonded connection of ceramic surfaces to metallic surfaces, in particular for bonding and secure connection of dental ceramics (4) to corresponding metal substrates (1), comprising as principal components; 3.0 to 6.0 wt. % sodium, 1.5 to 8 wt. % aluminium, 6.0 to 20.0 wt. % silicon, 3.0 to 6.0 wt. % potassium, each in the form of an oxide compound, at least one element chosen from the refractory metals, such as tungsten, molybdenum, rhenium, tantalum, niobium and gold in an effective amount and a residue of oxygen. The invention further relates to a method for the production of said medium and use thereof for the connection of a ceramic surface to a metal surface, in particular in the field of dentistry for the production of dental prostheses.
Treatment arm # 2 (interrupted Yasmin administration) will be identical to arm # 1 with the exception that the continuous administration of Yasmin will be interrupted by the substitution of placebo for Yasmin for one week during weeks 3, 8, and 14 of the study. The women participating in this treatment arm will experience episodes of menstruation after Yasmin withdrawal (when they are on placebo).
Systems, methods, and devices for verification of an immunization status of an individual and for secure data portability are provided. A system for verifying an immunization status of an individual includes a verification device, a vault computing device, and an immunization record database server. The verification device includes a web terminal configured to send an immunization status request including identifying data about the individual. The vault computing device receives the immunization status request and generates and sends an immunization record request including an insurance plan number corresponding to the individual. The immunization record database server has access to an immunization record database and retrieves immunization record data from the immunization record database using the insurance plan number and sends the immunization record data to the vault computing device. The vault computing device generates immunization status data representing the immunization status of the individual from the immunization record data and sends the immunization status data to the verification device. The verification device receives the immunization status data via the web terminal and displays the immunization status data in a user interface.
Macrophages are primary cells of the innate immune system that mediate tumor progression. However, the motile behavior of macrophages and interactions with tumor cells are not well understood. Here, we exploit the optical transparency of larval zebrafish and perform real-time imaging of macrophage-melanoma interactions. We found that macrophages are highly motile in the tumor microenvironment. Macrophages extend dynamic projections between tumor cells that precede invasive melanoma migration. Modulating macrophage motility with a dominant inhibitory mutation in Rac2 inhibits recruitment to the tumor and impairs tumor invasion. However, a hyperactivating mutation in Rac2 does not affect macrophage recruitment but limits macrophage projections into the melanoma mass and reduces invasive melanoma cell migration. Taken together, these findings reveal a role for Rac2-mediated macrophage protrusive motility in melanoma invasion.
Clinical Trial Education Intervention: The educational intervention will be delivered to approximately 200 participants by the Community Health Educators (CHEs) who will conduct workshops to deliver content and educational materials to patients about the importance of participating in cancer clinical trials. The workshops will last approximately 60 minutes, with 20 minutes to educate participants and 10 minutes to discuss the materials and answer any questions. Prior to and after the presentation, the CHE will administer the pre- and post-intervention survey to participants. Group sizes will be capped to 25 individuals per group.

Additionally, the CHE and/or Patient Navigators (PNs) will set up pathways for communication with key personnel (i.e. nurse navigators, clinical research coordinators, investigators) from partnering hospitals and clinics to facilitate patient referrals and evaluation for eligibility for clinical trials. The CHE and/or PN will keep track of those individuals that are referred by the partner hospital and clinics to track if the PN referral resulted in enrollment and participation in a clinical trial. The CHE and/or PN will also record and report quarterly the number of: (a) persons referred to therapeutic/intervention CTs at the UCCC and partnering hospitals; (b) referred persons screened for therapeutic/intervention CTs at the UCCC and partnering hospitals; (c)referred persons enrolled in therapeutic/ intervention CTs at the UCCC and partnering hospitals.
Fractures, breaks and nonunions of bones are more readily healed without muscle atrophy, etc., by injecting a liquefied composition containing a non-necrotic vascular sclerosing fatty acid compound into the site of the fracture or nonunions. No cast is used. The preferred non-necrotic vascular sclerosing fatty acid compound is sodium oleate or ethanolamine oleate. 
     Bones can be fused together by injecting a liquefied composition containing a non-necrotic vascular sclerosing fatty acid compound into the interface region between the bones. Normally a cast or brace is not used. The preferred non-necrotic fatty acid compound is sodium oleate. Splints and diffused splints can be prepared using the bone fusing technique.
Patients receive low-level laser therapy with LightWalker laser from the first day of conditioning chemotherapy till +2 day post hematopoietic stem cell transplantation. Additionally, standard supportive care is introduced.
Heat abstraction from the body's surfaces causes sensations of cold from the skin, orbit, nose, mouth, throat, upper esophagus, airways, and anogenital surfaces. The detection of heat abstraction at these sites is via TRPM8, a neuronal protein linked to nerve membranes. Chemical agents that act on TRPM8 can also produce sensations of cold, but the surface of the lower gastrointestinal tract (LGIT) does not “feel cold”, yet it contains cells with TRPM8. The pharmacology of TRPM8 in the LGIT is an unexplored subject. Menthol has a relaxant effect on gut smooth muscle, but this action is not via TRPM8. Here, a class of selective TRPM8 agonists, called 1-Dialkyl-phosphinoyl-alkanes (Dapa) were synthesized, and the potency and selectivity on TRP channels were characterized. Certain Dapa molecules were shown to inhibit neural signals in isolated vagus nerve and to exert anti-inflammatory effects in a model of heat-injury. When applied to the human colon muscle, a Dapa embodiment inhibited contractions with a median inhibitory concentration of 8 μg/mL. Methods for coating and formulation of Dapa with excipients for delivery to the colonic mucosa are described. The preferred Dapa embodiments are believed useful in treating the muscle spasms and the inflammation of LGIT dysfunction.
Provided is a plant having at least one of genetic characteristics (A)-(E) below. (A) Alleles in which the base at the position corresponding to position 40 of SEQ ID:1 is C are homozygous or heterozygous. (B) Alleles in which the base at the position corresponding to position 21 of SEQ ID:2 is T are homozygous or heterozygous. (C) Alleles in which the base at the position corresponding to position 28 of SEQ ID:3 is T are homozygous or heterozygous. (D) Alleles in which the base at the position corresponding to position 59 of SEQ ID:4 is C are homozygous or heterozygous. (E) Alleles in which the base at the position corresponding to position 64 of SEQ ID:5 is T are homozygous or heterozygous.
FIELD: chemistry; biochemistry. ^ SUBSTANCE: Lactobacillus delbrueckii TS1-06 strain is isolated from sour milk broth used in production of curdled milk. The obtained Lactobacillus delbrueckii TS1-06 strain is deposited in the collection of microorganisms of the department of microbiology of the Faculty of Biology of M.V. Lomonosov Moscow State University under registration number 497 CM MSU. The strain is used to make bacterial preparations and making sour milk broth as a food product for medical and preventive purposes. ^ EFFECT: high growth rate, wide range of antagonistic effect on gram-positive and gram-negative pathogenic bacteria, bile content, resistance to antibiotics, production of antibiotic-like substances (bacteriocins). ^ 3 dwg, 2 tbl, 3 ex
The procedure for the combined medicamentous correction of the vascular endothelial dysfunction in the patients with the diseases of kidneys provides for the biochemical examination of blood serum prior to the treatment, the assessment of the control indices of the vascular endothelial dysfunction, and the basic therapy. The concentration of nitrosothiol as the stable metabolite of nitric oxide (NO) is assessed as the control index of the functional state of the endothelium. The concentration of malonic dialdehyde (MDA) and SH groups is assessed as the index of the oxidative stress and the bioavailability of nitric oxide. MDA to SH groups is calculated. The content of interleukin-1? characterizes the anti-inflammatory activity. The control indices are assessed prior to the treatment and after two-week treatment. The decrease in the valuesassessed by less than 30% is an indication for the use of hypolipidemic drug, non-saturated fatty acids of omega-3 class at the therapeutically effective doses for the following two months.
The present study evaluated the adherence to guideline recommendations regarding the indication for inferior vena cava filter (IVCF) placement, retrieval rates, complications, thrombotic recurrences, and mortality. Patients in whom an IVCF was placed between 2015 and 2020 in a tertiary hospital were retrospectively included. We considered absolute indication of IVCF placement if all the guidelines evaluated agreed on the indication, relative indication if only some guidelines recommended it and without indication if none of the evaluated guidelines recommended it. From the 185 patients included; 47% had an absolute indication, 15% a relative indication, and 38% had no indication. Filter-associated complications and non-removal rates were 12.4% and 41%, respectively. Venous thromboembolism recurrence rate was 17.8%, being filter-associated complications (24.2 vs 9.8%, P = .02) and thrombosis of the inferior cava or iliac veins (12.1 vs 2.6%, P = .03) more frequent in this group. The mortality rate was 40%, with higher mortality risk in patients with co-existing cancer. Previous major bleeding, filter-associated complications, and mortality were associated with a major risk of non-removal. In conclusion, the adherence to guidelines regarding the indication of IVCF placement is still low and IVCF complications are not negligible. This fact is of special concern in the elderly, comorbid, and cancer patients.
PURPOSE:To produce a highly conc., low viscous pearl-like brightener-dispersed liquid industrially profitably by a method where an aq. solution of fatty acid glycol ester is fed to a heat exchanger, a refrigerant is fed to a jacket to deposit the fatty acid glycol ester on the inner surface of a cylindrical casing and the deposited ester is dispersed in the aq. solution while being scraped off. CONSTITUTION:An aqueous solution containing fatty acid glycol ester and surfactant and maintained at a temp. not below the melting point of the fatty acid glycol ester is fed to a heat exchanger consisting of a cylindrical casing 2 provided with a rotatable scraping blade 3 in its interior and a jacket 4 provided on the exterior of the cylindrical casing 2. A refrigerant is fed to the jacket 4 to deposit the fatty acid glycol ester on the inner surface of the casing 2 and, at the same time, the scraping blade 3 is made to rotate to disperse the deposited fatty acid glycol ester in the aq. solution while scraping it off. This method permits the industrially profitable production of a highly conc., low viscous pearl-like brightener-dispersed liquid having a beautiful pearly luster.
A sedation delivery system comprised of a bedside unit and a procedure unit. The bedside unit contains a series of connection points for receiving inputs from a series of patient monitors. The procedure unit contains a patient monitoring and a drug delivery pump or magnetic flux generator capable of sedative therapy to a patient. The sedation delivery system contains the capability to issue and receive a request from a non-sedated patient, issue and receive a request from a sedated patient and then to calculate a time difference. The sedation delivery system program operates the pump or magnetic flux generator based upon at least some of the patient outputs and program inputs including a calculated time difference. A removable umbilical cable connects the two units and allows the output of the patient monitors as well as other information to travel between the two units.
We aimed to evaluate the impact of fellowship training (FT) for thyroid specialists on the outcomes of patients with thyroid cancer. We reviewed surgeries performed for thyroid cancer before (non-FT group) and after (FT group) fellowship training and compared several variables, including length of stay of patients, tumor diameter, surgical method, lymph node dissection, parathyroid implantation, surgical duration, intraoperative blood loss, and postoperative complications. Compared with the non-FT group, the FT group had a shorter hospital stay, more adequate fine needle aspiration biopsy of the thyroid, less intraoperative blood loss, higher rate of parathyroid implantation, higher lymph node dissection rate, and lower nerve injury and hypoparathyroidism rates. When the surgical duration was < 200 min and/or only central lymph node dissection was performed, the FT group had a lower incidence of postoperative complications than the non-FT group. When, the incidence of postoperative complications, including postoperative nerve injury and hypoparathyroidism. In conclusion, FT for thyroid specialists is beneficial for patients with thyroid cancer and may allow a shorter hospital stay and reduced incidence of postoperative complication. Accordingly, FT may facilitate a more appropriate surgical approach with a preoperative pathological diagnosis.