anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: The innate branch of the immune system is important in early life, in particular for infants born preterm.
METHODS: We performed a longitudinal analysis of the peripheral monocyte compartment in extremely preterm children from a randomized, placebo-controlled study of probiotic supplementation. PBMCs and fecal samples were collected at several timepoints during the first months of life. Monocyte characteristics were analyzed by flow cytometry, and LPS-stimulated PBMC culture supernatants were analyzed by Luminex or ELISA. Plasma cytokines and gut microbiota composition were analyzed by ELISA and 16S rRNA-sequencing, respectively.
RESULTS: The extremely preterm infants had persistent alterations in their monocyte characteristics that were further aggravated in chorioamnionitis cases. They showed a markedly reduced TLR4 expression and hampered LPS-stimulated cytokine responses 14 days after birth. Notably, at later timepoints, TLR4 expression and LPS responses no longer correlated. Sepsis during the first weeks of life strongly associated with increased pro-inflammatory, and reduced IL-10, responses also at postmenstrual week 36. Further, we report a correlation between gut microbiota features and monocyte phenotype and responses, but also that probiotic supplementation associated with distinct monocyte phenotypic characteristics, without significantly influencing their responsiveness.
CONCLUSION: Extremely preterm infants have monocyte characteristics and functional features that deviate from infants born full-term. Some of these differences persist until they reach an age corresponding to full-term, potentially making them more vulnerable to microbial exposures during the first months of life.
PURPOSE:To readily obtain an extract containing matrine and/or oxymatrine having an antiulcer effect, by culturing tissues of a pea family plant and extracting the cultured substance with a suitable solvent. CONSTITUTION:Processes for culturing tissues of a pea family plant (e.g., Sophora flavescens or Sophora subprostrata) and obtaining an extract containing antiulcer components from the cultured substance obtained by the culture process are included. In the culture process, inducing of callus and culturing of the resultant callus are included. For inducing of callus, pieces of tissues or cell aggregations are cut or collected from the root, embryonic axis or cotyledon of a seedling or the root, stem, flower or pollen of a mature plant respectively of a pea family plant and used. The above-mentioned cell aggregations, etc., are ascptically cultured using a suitable medium to prepare the callus. The resultant callus is advantageously subjected to the subculture, etc., by the shaking culture using a liquid medium to provide the objective extract containing the antiulcer components.
Chronic wounds are "any interruption on the continuity of the body's tissue that requires a prolonged time to heal, does not heal, or recurs" (Wysocki, 1996). Venous leg ulcers, pressure sores, ischemic ulcers, and diabetic foot ulcers are examples of chronic wounds. These kinds of wounds affect over 4 million Americans each year and cost over $9 billion to treat. The pathophysiology of these wounds is not well understood and therapies directed at healing these wounds are not always successful for unknown reasons. To better understand the pathophysiology of these wounds we propose to collect blood by venipuncture from healthy volunteers. Blood will be used to prepare blood and plasma derived serum for use in an in vitro wound healing model and Boyden chamber assays to study cell migration, adhesion, genetic expression, expression of cell surface receptors, and protein expression to construct a profile of various healing processes. This baseline data will be used for studying the effect of acute and chronic wound fluids on cell migration, adhesion, genetic expression, expression of cell surface receptor and protein expression in an in vitro wound model (protocols to be submitted for each patient population).
Videolaryngoscopy is specialized equipment for airway management, where a camera located at the tip of the laryngoscope blade can visualize also structures that can´t be seen on direct laryngoscopy, co the operator can obtain superior view of aditus laryngis during intubation. Currently videolaryngoscopy is not routinely used for intubation and it is reserved for patients with difficult airway. The aim of the trial is to compare the elective use of videolaryngoscopy versus direct laryngoscopy for elective airway management (tracheal intubation). Patients after informed consent approval will be randomized to the interventional group (videolaryngoscopy) and control group (laryngoscopy). The randomization will be managed by the Institute of Biostatistics and Analyses by the Faculty of medicine, Masaryk university. The primary aim will be the first intubation attempt success rate, the secondary aims will be time to successful intubation (time to first ETCO2 wave), overall success rate, number of intubation attempts, incidence of aspiration, desaturation and incidence of overall complications in all operators, in trainees, residents (5-10 years of practice), consultants (10-15 years of clinical practice) and consultants with over 15 years of clinical practice.
Infantile nystagmus related abnormal head position is noted according to the axis, it can be anomalous horizontally (right or left head turn), vertically (chin up or down), torsionally (right or left head tilt) or in a mixed pattern. A head turn to right or left is the most common compensatory posture encountered in patients with infantile nystagmus with an eccentric null position. A prolonged head turn (HT) may interfere with the social interactions and the quality of life and may lead to skeletal deformities in the cervical spine with postural dysfunction and impaired movement pattern. Thus, the correction of an abnormal head turn is important to enlarge the visual field, to eliminate the possibility of abnormal contracture of the neck muscles and to permit an adequate vision.Various extraocular muscle surgeries have been advised to correct infantile nystagmus-related HT. Despite being the most common surgical technique used till today for correction of head turn related to nystagmus, Kestenbaum procedure has variable long- term results, limited success rate and involves four rectus muscles (recession/ resection). In graded Anderson procedure, only yoke muscle recession is done based on the amount of initial head turn leaving two untouched muscles.
* Do not fold or squeeze the Leucoflex CGP filter. Inappropriate handling may adversely affect filtration.
  * Check for kinks in the tubing prior to collection and filtration.
  * Rx only.



The protective shield for needle Secuvam (A) and the vacuum tube adapter Vacuvam (B) features of the collection set aid in the safe collection of vacuum tube samples from the sample diversion pouch Bactivam (C) and the disposal of donor needles after blood collectin by providing protection from accidental needlestick.

All or part of this medical device is made of PVC plasticized with DEHP. According to some studies, DEHP could potentially be harmful to the reproductive system of male fetuses. The prescriber is solely responsible for choosing to use this device on women who are either pregnant or breast-feeding, or on young male infants. Nevertheless, DEHP-plasticized PVC is in compliance with the European Pharmacopeia.

All manufacturing processes and all components in contact with the donors, the users and the blood components dedicated to the patients are not made with natural rubber latex.
Between the administration of sedation/neuromuscular blockade and intubation, ventilation will not be provided unless the patient experiences an arterial oxygen saturation less than 90%. For patients who experience an oxygen saturation less than 90% after induction, bag-valve-mask ventilation may be provided.
PURPOSE:To provide the subject composition which is composed of cell bodies or blasts of Lactobacillus and saccharides, thus useful as a prophylactic and therapeutic agent for Clostridium difficile diarrhea and pseudomembranous colitis with extremely reduced toxicity. CONSTITUTION:The objective composition comprises the cell bodies or blasts of a lactobacillus, suitably Clostridium butyricum MIYAIRI 588 (FERM No. 2789) and a saccharide such as starch or raffinose. The amount of the saccharide is preferably 1mg/10g per 10<8> CFU of the cell bodies or the blasts. The composition is given in an amount corresponding to 10<6> to 10<9> CFU as the cell bodies or blasts of the lactobacillus per kg human body weight. The spore is obtained by anaerobic proliferation of the lactobacillus in a medium of usual bouillon containing 2% corn starch.
The invention belongs to the technical field of biological medicines, and relates to a prenatal noninvasive diagnosis molecular marker for cleft lip and palate and application thereof. The molecular marker for prenatal noninvasive diagnosis of cleft lip and palate fetus consists of 4 genes EN2, LIN28A, HHIP and GLI 2. The molecular marker for prenatal noninvasive diagnosis of cleft lip and palate fetus is applied to preparation of prenatal screening, early warning, clinical diagnosis and biochemical inspection products for cleft lip and palate fetus. The invention discovers and verifies that the gene or protein expression abnormality of EN2, LIN28A, HHIP and GLI2 has close correlation with the occurrence of cleft lip and palate fetus for the first time, and has a large number of verified samples and accurate results. The relevance provides a new way for prenatal screening, early warning and diagnosis of cleft lip and palate fetus. The marker related to prenatal noninvasive diagnosis of the cleft lip and palate fetus provided by the invention provides a prenatal diagnosis or risk monitoring service of the cleft lip and palate fetus, and consultative services for diagnosis and prognosis are cooperatively or independently sold to hospitals and clinics.
Participants who are determined to undergo open abdomen surgery will be screening for the eligibility first. If eligible and agreed to participate, each participant will be assigned to either the experimental group or control group based on the electronic randomization. The experimental group will use the plastic ring wound retractor, while the control group will use a conventional surgical pad for wound protection method. Each participant will be blind to the randomization result because he/she will be under general anesthesia. Once the surgery is finished, the patient will be assessed on the surgical wound at postoperative day 1, 7, 14, 30. Two groups will be compared for the surgical wound infection rate.
The goal of this preregistered scoping review is to create an overview of the research on developmental prosopagnosia (DP). Through analysis of all empirical studies of DP in adults, we investigate 1) how DP is conceptualized and defined, 2) how individuals are classified with DP and 3) which aspects of DP are investigated in the literature. We reviewed 224 peer-reviewed studies of DP. Our analysis of the literature reveals that while DP is predominantly defined as a lifelong face recognition impairment in the absence of acquired brain injury and intellectual/cognitive problems, there is far from consensus on the specifics of the definition with some studies emphasizing e.g., deficits in face perception, discrimination and/or matching as core characteristics of DP. These differences in DP definitions is further reflected in the vast heterogeneity in classification procedures. Only about half of the included studies explicitly state how they classify individuals with DP, and these studies adopt 40 different assessment tools. The two most frequently studied aspects of DP are the role of holistic processing and the specificity of face processing, and alongside a substantial body of neuroimaging studies of DP, this paints a picture of a research field whose scientific interests and aims are rooted in cognitive neuropsychology and neuroscience. We argue that these roots - alongside the heterogeneity in DP definition and classification - may have limited the scope and interest of DP research unnecessarily, and we point to new avenues of research for the field.
Endotoxin is a general term for toxic substances in Gram-negative bacteria, whose damaging effects are mainly derived from the lipopolysaccharides (LPS) in the cell walls of Gram-negative bacteria, and is a strong pyrogen. Obesity is a chronic, low-grade inflammatory condition, and LPS are thought to trigger and exacerbate it. The gut flora is the largest source of LPS in the body, and it is increasingly believed that altered intestinal microorganisms can play an essential role in the pathology of different diseases. Today, the complex axis linking gut flora to inflammatory states and adiposity has not been well elucidated. This review summarises the evidence for an interconnection between LPS, obesity, and gut flora, further expanding our understanding of LPS as a mediator of low-grade inflammatory disease and contributing to lessening the effects of obesity and related metabolic disorders. As well as providing targets associated with LPS, obesity, and gut flora, it is hoped that interventions that combine targets with gut flora address the individual differences in gut flora treatment.
Patients randomized to this arm will receive eHealth materials every 2-4 weeks over the 12-month intervention. However, the exact nature of timing, dose, and delivery channel will be informed by the formative research.
In the Study PDX-008, 36% of patients (n = 40) were 65 years of age and over. No overall differences in efficacy and safety were observed in patients based on age (< 65 years compared with ≥ 65 years). Due to the contribution of renal excretion to overall clearance of pralatrexate (approximately 34%), age-related decline in renal function may lead to a reduction in clearance and a commensurate increase in plasma exposure. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Since elderly patients may be at higher risk, monitor more closely. Omit dose and subsequently adjust or discontinue therapy for adverse reactions [see Dosage and Administration (2.4)].
Salicylate toxicity may result from acute ingestion (overdose) or chronic intoxication. The early signs of salicylic overdose (salicylism), including tinnitus (ringing in the ears), occur at plasma concentrations approaching 200 mcg/mL. Plasma concentrations of aspirin above 300 mcg/mL are clearly toxic. Severe toxic effects are associated with levels above 400 mcg/mL [see Clinical Pharmacology (12.3)].  A single lethal dose of aspirin in adults is not known with certainty but death may be expected at 30 g. For real or suspected overdose, contact a Poison Control Center immediately.

Signs and Symptoms: In acute overdose, severe acid-base and electrolyte disturbances may occur and are complicated by hyperthermia and dehydration. Respiratory alkalosis occurs early while hyperventilation is present, but is quickly followed by metabolic acidosis.

Treatment: Treatment consists primarily of supporting vital functions, increasing salicylate elimination, and correcting the acid-base disturbance. Gastric emptying or lavage is recommended as soon as possible after ingestion, even if the patient has vomited spontaneously. After lavage or emesis, administer activated charcoal, as a slurry, if less than 3 hours have passed since ingestion.

Severity of aspirin intoxication is determined by measuring the blood salicylate level. Monitor acid-base status with serial blood gas and serum pH measurements. Maintain fluid and electrolyte balance.

In severe cases, hyperthermia and hypovolemia are the major immediate threats to life. Replace fluid intravenously and correct acidosis. Monitor plasma electrolytes and pH to promote alkaline diuresis of salicylate if renal function is normal. Glucose may be required to control hypoglycemia.

Hemodialysis and peritoneal dialysis can reduce the body aspirin content. In patients with renal insufficiency or in cases of life-threatening intoxication, dialysis is usually required. Exchange transfusion may be indicated in infants and young children.
PURPOSE: To obtain an excellent revitalizing hair tonic by using monoxidil and a monoalkyl ether of an aliphatic polyalcohol as a transdermal absorption enhancer for monoxidil. CONSTITUTION: The transdermal absorption of monoxidil is increased by using an aliphatic monoalkylether of an aliphatic polyalcohol. Glycerin is preferred as aliphatic polyalcohol. α-Monoisostearylglycerylether is preferred as a monoalkyl ether of an aliphatic polyalcohol. In a preferred formulation, 0.5-5%.wt. of monoxidil [chemical name: 6-(1-piperidinyl)-2,4-pirimidiamine-3- oxide] is used. The amount of monoalkylether of aliphatic polyalcohol in the formulation is preferably in 1-20%.wt. This revitalizing hair tonic is used as lotion, tonic, cream, ointment and aerosol.
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children and adolescents, affecting approximately one in 1000 children in North America. It is diagnosed in children younger than 16 years of age with arthritis in one or more joints for at least six weeks after other causes have been excluded. Arthritis in JIA is characterized by stiffness, pain and swelling of affected joints. The disease course of JIA may involve flares of increased disease activity or chronic persistent joint inflammation, even into adulthood. Various complications may arise secondary to ongoing disease activity or treatment, including joint damage and deformity, growth abnormalities and osteoporosis with fragility fractures The prevalence of refractory pain in children with arthritis is of particular concern because it often contributes to poor physical and psychosocial outcomes. Increased daily symptoms of pain predict considerable functional disability, including significantly reduced participation in school, social and physical activities, and augmented mood disturbance
Terazosin was devoid of mutagenic potential when evaluated in vivo and in vitro (the Ames test, in vivo cytogenetics, the dominant lethal test in mice, in vivo Chinese hamster chromosome aberration test and V79 forward mutation assay).

Terazosin, administered in the feed to rats at doses of 8, 40, and 250 mg/kg/day (70, 350, and 2100 mg/M2/day), for two years, was associated with a statistically significant increase in benign adrenal medullary tumors of male rats exposed to the 250 mg/kg dose. This dose is 175 times the maximum recommended human dose of 20 mg (12 mg/M2). Female rats were unaffected. Terazosin was not oncogenic in mice when administered in feed for 2 years at a maximum tolerated dose of 32 mg/kg/day (110 mg/M2; 9 times the maximum recommended human dose). The absence of mutagenicity in a battery of tests, of tumorigenicity of any cell type in the mouse carcinogenicity assay, of increased total tumor incidence in either species, and of proliferative adrenal lesions in female rats, suggests a male rat species-specific event. Numerous other diverse pharmaceutical and chemical compounds have also been associated with benign adrenal medullary tumors in male rats without supporting evidence for carcinogenicity in man.

The effect of terazosin on fertility was assessed in a standard fertility/reproductive performance study in which male and female rats were administered oral doses of 8, 30 and 120 mg/kg/day. Four of 20 male rats given 30 mg/kg (240 mg/M2; 20 times the maximum recommended human dose) and five of 19 male rats given 120 mg/kg (960 mg/M2; 80 times the maximum recommended human dose) failed to sire a litter. Testicular weights and morphology were unaffected by treatment. Vaginal smears at 30 and 120 mg/kg/day, however, appeared to contain less sperm than smears from control matings and good correlation was reported between sperm count and subsequent pregnancy.

Oral administration of terazosin for one or two years elicited a statistically significant increase in the incidence of testicular atrophy in rats exposed to 40 and 250 mg/kg/day (29 and 175 times the maximum recommended human dose), but not in rats exposed to 8 mg/kg/day (> 6 times the maximum recommended human dose). Testicular atrophy was also observed in dogs dosed with 300 mg/kg/day (> 500 times the maximum recommended human dose) for three months but not after one year when dosed with 20 mg/kg/day (38 times the maximum recommended human dose). This lesion has also been seen with prazosin hydrochloride, another (marketed) selective-alpha-1 blocking agent.
PURPOSE:The titled composition, obtained by uniformly coating the surface of small granular cores with a diclofenac salt and a binder and having improved stability. CONSTITUTION:A granular composition of a diclofenac salt obtained by dissolving 1-30% diclofenac salt, e.g. diclofenac sodium, etc., and 0.1-5% binder, e.g. mixture of one or two or more or water-soluble high polymers, pH- dependent high polymers and water-insoluble high polymers, polyvinylpyrrolidone, ethyl cellulose or eudragit, etc., in water.organic solvent, e.g. water.ethanol, etc., and spray coating small granular cores with the resultant solution. Furthermore, coating with a sustained release film, enteric coating, etc., may be carried out to give a continuous multi-layered material. EFFECT:The solution is readily prepared and the subsequent production process can be continuously performed without requiring any lubricant, etc., and scattering of powder.
The invention relates to medicinal powder for preventing and treating a porcine reproductive and respiratory syndrome. The medicinal powder is characterized by comprising the following Chinese herbal medicines in part by weight: 50 to 60 parts of gypsum, 18 to 20 parts of rehmannia root, 10 to 12 parts of weeping forsythia, 10 to 18 parts of root of red-rooted salvia, 15 to 20 parts of phellodendron, 10 to 20 parts of liquoric root and 40 to 50 parts of indigowoad root. A preparation method for the medicinal powder comprises the following steps of: mixing the Chinese herbal medicines, and crushing or crushing, and mixing. The Chinese herbal medicines are combined to exert the effects of clearing heat, detoxicating, dispelling wind and heat from body and eliminating carbuncle and stagnation under the combined action. The aim of treating and preventing the porcine reproductive and respiratory syndrome is fulfilled by adding the medicinal powder into daily feed. The medicinal powder has the advantages that: the prevention and treatment effects are remarkable; toxic and side effects are eliminated; the raw materials are readily available; and the price is low.