anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients who consent to this study will receive treatment for four 28 day cycles unless they are unable to continue study treatment due to toxicity or disease progression. Paclitaxel and carboplatin will be given intravenously on day 1 of each cycle and galunisertib in pill form on days 4-17. No medicine will be given on days 17-28 of each cycle. Patients may have the option of continuing treatment with the study drug if they complete the 4 cycles the study requires. Subjects will receive tests and procedures that are part of regular cancer care as well as those required for the purposes of the study. Blood samples will be taken to monitor the level of study drug in the blood. Patients will have the option of allowing blood and tumor samples to be used for future research.
Antiretroviral treatment (ART) has converted HIV from a lethal disease to a chronic condition, yet co-morbidities persist. Incomplete immune recovery and chronic immune activation, especially in the gut mucosa, contribute to these complications. Inflammasomes, multi-protein complexes activated by innate immune receptors, appear to play a role in these inflammatory responses. In particular, preliminary data indicate the involvement of IFI16 and NLRP3 inflammasomes in chronic HIV infection. This study explores inflammasome function in monocytes from people with HIV (PWH); 22 ART-treated with suppressed viremia and 17 untreated PWH were compared to 33 HIV-negative donors. Monocytes were primed with LPS and inflammasomes activated with ATP in vitro. IFI16 and NLRP3 mRNA expression were examined in a subset of donors. IFI16 and NLRP3 expression in unstimulated monocytes correlated negatively with CD4 T cell counts in untreated PWH. For IFI16, there was also a positive correlation with viral load. Monocytes from untreated PWH exhibit increased release of IL-1α, IL-1β, and TNF compared to treated PWH and HIV-negative donors. However, circulating monocytes in PWH are not pre-primed for inflammasome activation in vivo. The findings suggest a link between IFI16, NLRP3, and HIV progression, emphasizing their potential role in comorbidities such as cardiovascular disease. The study provides insights into inflammasome regulation in HIV pathogenesis and its implications for therapeutic interventions.
This invention is based upon pharmaceutical bilayer tablet composition. It comprises a first outer region is cefixime which partly surrounds an inner center, a second outer region is clavulanate potassium which also partly surrounds the center, and the outer regions together form a continuous assorted layer fully surrounding the center. Dry granulation method use for both layers by selection of inert and thermostable excipients.Each film coated tablet contains cefixime and clavulanate potassium active pharmaceuticals ingredients. It is particularly suitable for mostly bacterial and microbial infection and diseases. Both drugs having different physicochemical properties to overcome chemical interference between both drugs and maximum stability and bioavailability achieved by this novel drug formation as bilayer tablet More stability can be observed in the case of chemical interference. 100% Bioavaility can be found.
Three tablets of matching placebo will be administered on Day-1 of the 28-day treatment period. From Day-2 to Day-28, participants will take 1 placebo tablet.
Adhesion and signaling by integrins requires their dynamic association with non-integrin membrane proteins. One such protein, the glycolipid-anchored urokinase receptor (uPAR), associates with and modifies the function of the β2 integrin Mac-1 (CD11b/CD18). We have identified a critical non-I domain binding site for uPAR on CD11b. Recombinant soluble uPAR and cells expressing uPAR bound to immobilized M25, binding being promoted by urokinase and blocked by soluble M25, but not a scrambled control or homologous peptides from other β2-associated a chains. In the a-propeller model of a chain folding, M25 spans an exposed loop on the ligand-binding, upper surfaced of αM, identifying uPAR as an atypical αM ligand. Although not blocking ligand binding to Mac-1, M25(25-100 νM) inhibited leukocyte adhesion to fibrinogen, vitronectin, ad cytokine-stimulated endothelial cells. M25 also blocked the association of uPAR with β1 integrins and impaired β1 integrin-dependent spreading and migration of human vascular smooth muscle cells on fibronectin and collagen. Thus, uPAR associates with integrins directly and tat disruption of this association broadly impairs integrin function, providing a novel strategy for regulation of integrin function in the settings of inflammation and tumor progression.
Clinical studies of APRISO did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently than younger subjects. Other reported clinical experience has not identified differences in responses between elderly and younger patients. In general, the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy in elderly patients should be considered when prescribing APRISO.

Reports from uncontrolled clinical studies and postmarketing reporting systems suggested a higher incidence of blood dyscrasias, i.e., neutropenia, pancytopenia, in patients who were 65 years or older who were taking mesalamine-containing products such as APRISO. Caution should be taken to closely monitor blood cell counts during mesalamine therapy.

Mesalamine is known to be substantially excreted by the kidney, and the risk of adverse reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken when prescribing this drug therapy [see Warnings and Precautions (5.1)].
New organometallic complexes (A) are obtained by reacting strontium cation with sitosterol (or a plant extract containing sitosterol) and at least one mono-, di- or triglyceride (I). New organometallic complexes (A) are obtained by reacting strontium cation with sitosterol (or a plant extract containing sitosterol) and at least one glyceride of formula R1OCH2-CH(OR2)-CH2OR3 (I). R1H, acyl residue of a 14-24C linear or branched, saturated or unsaturated fatty acid or mono-, di- or trigalactose or -glucose; R2acyl residue of a 2-18C linear or branched, saturated or unsaturated fatty acid; and R3H or acyl residue of a 14-24C linear or branched, saturated or unsaturated fatty acid. ACTIVITY : Osteopathic; Antianemic. In tests in female rats, rectal administration of 12.15 mg/kg of strontium per day for 3 weeks in the form of a complex (A') obtained from sitosterol, a mixture of 1,2- and 1,3-diolein and strontium sulfate significantly increased bone growth, whereas similar administration of 68.2 mg/kg of strontium per day in the form of the chloride had no effect on bone growth. MECHANISM OF ACTION : Strontium source; Calcium metabolism regulator; Osteoblast multiplication stimulant; Hematopoietic stem cell production stimulant.
BACKGROUND: Sensory impairment significantly reduces speech discrimination and perception ability, presenting a challenge to effective communication. It can lead to social withdrawal and a reduced social network which can lead to cognitive impairment, seriously affecting the quality of life of older people. However, it is unclear which intervention components are effective to improving social network in older people with sensory impairment.
OBJECTIVE: The aim of this systematic review was to summarize interventions designed to improve social network in older people with sensory impairment.
METHODS: We searched seven databases from inception to December 1, 2023. Eligible studies included randomized clinical trials (RCT) and quasi-experimental studies of interventions for older people with sensory impairment aimed at improving social networks. Two reviewers searched databases, extracted data, and assessed the quality of the included studies independently.
RESULTS: Nine studies including five RCTs and four quasi-experimental studies were selected, enrolling 721 older people with sensory impairment. Methodological quality of the studies was modest. Eight studies demonstrated a positive impact of the interventions used in older people with sensory impairment. The detailed effective intervention components may include communication strategies, resources for older people and their significant others, exercise or tech-back of communication, sensory device fitting, and use and maintenance of sensory devices.
CONCLUSION: There are few interventions available for improving social network in older people with sensory impairment. Most interventions mainly focus on communication education and care, and sensory device fitting and education. To improve the social network in older people with sensory impairment, it is necessary to develop more effective, multidisciplinary collaborative effective interventions and conduct more high-quality original studies.
PROBLEM TO BE SOLVED: To provide compositions and methods for treating lysosomal disorders.SOLUTION: The invention provides a composition and a method for treating lysosomal disorders using a class of substituted imidazole derivatives or compounds. In some aspects of the invention, the chemical compound of Formula 1 or 1a (such as Formula 1b or 2) is administered to a subject suffering from lysosomal storage disease. The lysosomal storage disease is characterized by defect in glycosphingolipid synthesis. In some embodiments, the defect is present in synthesis of neutral glycosphingolipid. In other embodiments, the disease is characterized by a defect in ceramide synthesis. The disease may be Gaucher's disease or Fabry's disease.
OBJECTIVE: The issue of low consumption among rural households in China has a longstanding history, and the experience of infectious diseases may exacerbate the existing challenges in fostering consumption growth. However, studies that characterize the impact of infectious diseases on household consumption are limited in China. This study aims to explore rural household consumption responses to infectious diseases post-assessment, and identify the underlying mechanisms.
METHODS: A total of 1,539 rural households from China Family Panel Studies (CFPS) datasets of 2014, 2016, 2018, and 2020 were recruited as the study sample. The presence of infectious disease experience was employed as the independent variable and household consumption as the dependent variable. A panel fixed effects (FE) regression model was initially employed to identify the influence of infectious disease experiences on rural household consumption. The instrumental variable (IV) method was used to address potential endogeneity between independent and dependent variables. Robustness checks such as Propensity Score Matching (PSM) test were employed to ensure the reliability of the findings.
RESULTS: The results reveal a statistically significant negative impact of infectious disease experiences on consumption over time, becoming no more significant at around 7-9 years post-disaster. This effect leads to more pronounced consumption deprivation for households with limited health insurance coverage and heightened healthcare resource constraints. The mechanism test indicates that infectious disease experiences affect the consumption levels of rural households through channels that include income constraints, the crowding-out of healthcare expenditure, and risk perception, with the precautionary savings motive acting as a moderator. Furthermore, the diminishing effect of infectious diseases on individual consumption surpasses that of natural disasters. Temporal discrepancy is observed in the impacts of infectious and chronic disease shocks on household consumption. The accumulation of liquid assets emerges as an effective strategy for households to mitigate the impact of infectious disease shocks.
CONCLUSION: The findings underscore the importance of integrating short- and long-term policies to bolster consumption capacity, strategically allocate inter-regional medical resources, and fortify the resilience of rural households against economic risks.
Stage III Grade C group received Non-Surgical Periodontal Treatment. They received Scaling and Root Planning procedure with ultrasonic scalers and hand curettes. The patients were subjected to quadrant-wise full-mouth subgingival scaling and root planning under local anesthesia. The entire non-surgical periodontal treatment of periodontitis groups was completed in a total of 4 sessions in two weeks.
Timed bright light exposure will be delivered in a controlled laboratory setting (10,000 lux) designed to delay the DLMO to 4 am or later. This would shift the circadian nadir (e.g., the period of maximal sleepiness) into the typical daytime sleep period after the nightshift (i.e., circadian nadir at \~10am). Bright light will be delivered in a controlled lab environment using a full spectrum light-box with UV filter (Sunbox Sunray II) to achieve a robust reduction of circadian misalignment. The light schedule will be tailored to each individual nightshift worker, determined by: 1) their baseline circadian phase, and 2) the human phase response curve adjusted to the individual's baseline circadian phase.
The present invention relates to a malonic selenium bridged bicyclodextrin platinum supermolecule complex, a preparation method and the use thereof. The complex has a chemical formula of (C87H144O68Se2.8H2O)2. PtCl4, aquatic dissolvability is 240 mmol/L measured by platinum, and a coordination ratio of the malonic selenium bridged bicyclodextrin to the platinum is 2:1. The complex can be prepared by a simple synthetic method. Because the complex has the characteristics of high water solubility, low price and easy preparation, the supermolecule complex can be used as novel anticancer medicine (comprising medicine for treating urination reproduction cancer, nasopharyngeal cancer, head and neck cancer, lung cancer, liver cancer, skin cancer, lymphosarcoma, etc.) to be applied to a clinic, and the present invention has wide use prospects. The structure of the complex is disclosed in the specification, wherein beta-CD is beta-cyclodextrin.
Eosinophilic Esophagitis (EoE) is a chronic allergic/immune condition of the esophagus that affects all ages, from infancy through adulthood. The chronic inflammation can lead to symptoms that vary with age. It is critically important to know symptoms in the infancy/toddler period because in this period, they can't express symptoms directly. The frequent symptoms seen in this period are; vomiting, refusing sucking and eating, failure to thrive, and abdominal pain. School-aged children with EoE have decreased appetite, recurrent abdominal pain, vomiting, food impaction, and dysphagia. Feeding dysfunction (feeding refusal, slowly eating, picky eater, etc..) is one of the trouble issues in this period. Children who can't experience different texture (especially solid) and tastes of foods keep on eating with their same safe feeding habits. Whereas experiences gained in early childhood period form the basis of sensory and motor development. As currently known, humans have eight senses (visual, auditory, gustatory, olfactory, tactile, proprioception, vestibular, and interoception). Each sense is unique, a form of information and nourishment for the nervous system. In the meantime, it is crucial to receive, interpret, and integrate all this information from all these senses at a time. Sensory integration (SI) is the term used for the brain processing information that comes through the senses. The SI begins in the womb as the fetal brain senses the movements. Childhood activities and play lead to a lot of sensory integration as the child organizes the sensations of his body and gravity, along with sight and sound. If there is a problem in any sense, such as receiving or interpreting, the SI process can be interrupted, and this may result in sensory processing disorder (SPD). It is crucial to notice SPD in childhood because SPD can affect a child's development and education (learning, reading, math, visual and auditory perception, and skilled motor tasks).

Food intake is one of the most multi-sensory daily experiences (sight, smell, taste, sounds, texture of food) for both children and adults. In children with EoE, feeding dysfunction (vomiting, food impaction, regurgitation..) can affect the oral sensory system. Even considering that all the senses work in interaction, more senses can be affected.

To date, there is no study that has investigated sensory processing issues in children with EoE. Therefore, the present study aimed to compare sensory processing between children with EoE and healthy controls and also examine the correlations between sensory processing and disease characteristics among children with EoE.
FIELD: biotechnology, medicinal veterinary science. SUBSTANCE: invention relates to making dried medicinal formulas for oral or intranasal use that show probiotic, immunomodulating and antiviral activities. Immunoprobiotic preparation has bacterial mass of lyophilized living bifidobacterium cells and nonpathogenic streptococci showing antagonistic activity with respect to enteropathogenic microorganisms of poultry intestine, dried mixture of alpha-2-interferon and gamma-interferon and dry aluminium hydroxide at the following ratio of components, wt.-%: dried bacterial mass 4-5; mixture of alpha-2-interferon and gamma-interferon 0.2-0.4 and dry aluminium hydroxide - the rest. Invention can be used for prophylaxis of infectious diseases associated with disorders in immunocompetent regions of intestine and liver that promote the development of secondary dysbacteriosis in poultry under conditions of industrial poultry farming. EFFECT: enhanced safety of poultry stock. 7 tbl, 5 ex
Infants with severe neurologic disability often have difficulty in eating by mouth due to a disruption in the swallowing process. This swallowing dysfunction, also known as dysphagia, is often evident early in life and when severe can be permanent. Dysphagia can lead to an inability to take in enough food to maintain an adequate weight and result in malnutrition. It also can result in food going into the lungs instead of the stomach, resulting in an illness called aspiration pneumonia. Both of these complications may require feeding by tube either through the nose into the stomach or directly into the stomach via the abdominal wall, to bypass the swallowing process. This process is resource intense, can be associated with a number of complications and may result in a reduced quality of life for both the infant and caregivers. Currently, there are no effective treatments to change the natural course of dysphagia in this context.
BACKGROUND: Feeding critically ill persons in Intensive Care Units (ICUs) is challenging as the nutritional substances pose severe health outcomes or can improve their well-being and length of stay (LOS) in the hospital. Our main objective is to investigate the effects of adopting low caloric intake among patients with vital signs in the nutritional support of critically ill patients in ICUs, focusing on reducing mortality rates and length of stay (LOS) in hospitals.
METHOD: The initial literature search was performed in PubMed, the Cochrane Library of Trials, and MEDLINE. The network meta-analysis was performed per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Two independent reviewers were assigned data selection and extraction roles. Our study mainly included randomised controlled trials (RCTs) whose titles and abstracts were screened, after which duplicates were excluded. The remaining eligible studies were subjected to full-text analysis to identify data related to the topic of the present study. Analyses were performed using the Cochrane Risk of Bias tool, R software and MS Excel.
RESULTS: Twenty-two studies (involving 9 539 participants) met the inclusion criteria and were subjected to the network meta-analysis. In mortality rates, the greatest rank observed corresponded to a reduction of 71%. The regression of the effects of low caloric intake explained a 5.29% variation in LOS. A weak positive correlation was found between LOS and low caloric intake among critically ill patients in ICUs. Thus, Low caloric intake decreased mortality rates and lowered LOS.
CONCLUSIONS: Our study found that low caloric intake reduces mortality rate and hospital LOS among critically ill patients. Secondary outcomes include nosocomial infection, clinical outcomes, functions, digestive infections, improved quality of life, resulting survival rates, ventilator days, bacteremia, blood glucose levels, diarrhoea, and tube replacement. Our findings have clinical implications for clinicians in the ICU, who should consider developing individualised nutritional plans for critically ill patients. Moreover, regular monitoring of nutritional intake and response is crucial. Healthcare providers should closely monitor patients' nutritional status, vital signs, and clinical outcomes.
Transbronchial puncture is a technique known for many years with the first description found in 1949 by Shieppati. Subsequently, this technique allowing an exploration of the mediastinal lymph nodes became widespread with the work of Wang in 1983. However, the need to have exact knowledge of the different puncture sites in order to obtain maximum profitability with this examination in particular In staging and diagnosis in bronchopulmonary cancers (CBP) explains a significant difference in profitability between operators based on their experience. It was not until 1990 that Germans coupled the technique of radial ultrasound with that of bronchoscopy by introducing a balloon catheter inflated with a liquid allowing the best transmission of ultrasound. It is the German team of Herth who developed this technique in 1999 under the name of bronchial echo-endoscopy (EBUS). The association of echo-endoscopy before transbronchial punctures significantly improves the performance of the examination. In 2004, Yasufusu shows the interest of the real-time visualization of the lymph nodes for the marking as well as the punctures. Therefore, the indications for bronchial echoendoscopies with transbronchial needle puncture (EBUS-PTBA) are precisely defined in the nodal staging of CBP with good profitability and a reduction in surgical mediastinoscopy. Then, over time, there is an extension of indications with the diagnosis of Non-Small Cell Lung Broncho-Pulmonary Cancers (NSCLC) or Small Cell Broncho-Pulmonary Cancers (CBPC), the diagnosis of ganglion metastases of extra-thoracic primary tumors , Diagnosis of sarcoidosis or other more anecdotal uses (tuberculosis, lymphoma).

Two Picard centers were among the first in France to be equipped with echoendoscopes (2007 for the CH of Saint Quentin and 2008 for the CHU of Amiens). This allows our two centers to have a fairly consistent retreat on the technique since its implantation in France. While many studies are concerned with one or other indication in isolation, there is no study to the best of our knowledge relating the evolution over time of the respective share of each of these indications in daily practice . Given the current multiplication of potential indications for EBUS-PTBA, it seems interesting to analyze the place of these new indications in the daily activity of endoscopic centers equipped with an echo-endoscope. The main objective is to evaluate the respective share of each indication over time over the study period. Secondary objectives are the evaluation of the diagnostic performance of EBUS-PTBA, the evaluation of the abusively carried-out EBUS-PTBA (examination carried out for purely diagnostic purposes, whereas conventional bronchial fibroscopy Diagnosis of certainty) and evaluation of concordance between EBUS-PTBA and surgery in CBP staging indications.