anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To improve physical properties of spiculisporic acid which is a specific organic acid derived from organisms and a neutralized salt thereof and to improve surface activity thereof while maintaining highly safe characteristics with a slight environmental load.  <P>SOLUTION: A gemini type surfactant composed of a spiculisporic acid derivative represented by the formula or the neutralized salt thereof is obtained. The surfactant has advantages as follows. The surfactant has slight irritation to skin, good biodegradability and excellent emulsification stability with the slight environmental load while utilizing highly safe surface activity. When the surfactant is used in a cosmetic, moisture retaining properties and skin detergency are good with good compatibility with other surfactants and excellent convenience during preparation of a surface-active composition.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Participants will receive placebo on Day 1 and will be followed for at least 12 weeks in treatment period 1. An optional dose of BOTOX in Treatment 2 can be requested between Weeks 12 and 24.
One dose each of treatments A: \[14C\] TD-4208 20 μg IV administered in a fasted state over 30 minutes. B: \[14C\] TD-4208 200 μg oral solution administered in a fasted state.
The photosensitizer, methylene blue, is applied topically to the ulcer surface and the ulcer was shielded from light for 15 min. Then the ulcer area is illuminated using a photon therapy instrument for 20 minutes. Photodynamic therapy is applied once a day for a total of seven times.
Ganciclovir Injection should be used with caution in patients with impaired renal function because the half-life and plasma/serum concentrations of ganciclovir will be increased due to reduced renal clearance. If renal function is impaired, dosage adjustments are recommended Ganciclovir Injection should be used with caution in patients with impaired renal function because the half-life and plasma/serum concentrations of ganciclovir will be increased due to reduced renal clearance. If renal function is impaired, dosage adjustments are recommended [see Dosage and Administration (2.5), Use in Specific Populations (8.5, 8.6)] . 

Increased serum creatinine levels have been reported in elderly patients and in transplant recipients receiving concomitant nephrotoxic medications (i.e., cyclosporine and amphotericin B). Monitoring renal function during therapy with Ganciclovir Injection is essential, especially for elderly patients and those patients receiving concomitant agents that may cause nephrotoxicity . Increased serum creatinine levels have been reported in elderly patients and in transplant recipients receiving concomitant nephrotoxic medications (i.e., cyclosporine and amphotericin B). Monitoring renal function during therapy with Ganciclovir Injection is essential, especially for elderly patients and those patients receiving concomitant agents that may cause nephrotoxicity [see Dosage and Administration (2.5), Drug Interactions (7), Use in Specific Populations (8.5)] .
An induction heating appts. for plastics extruders employs induction coils with E-shaped cores. The coils are mounted in a 2-piece housing which is clamped on the extruder barrel by spring tension. The extruder barrel (1) is heated by induction coils (2,2a,3,3a) in which the coil is wound on the central arm (4,4a,5,5a) of an E-shaped laminated iron core. The coils are magnetically coupled to the barrel by an interlayer (6,6a,7,7a) which covers the core. Pairs of coils are mounted in a 2-piece housing (8,9) which is assembled and clamped on the barrel (1) periphery by means of threaded pins (13), carrying washers (15) and nuts (16,17). Disc spring stacks (14) are interposed between the washers (15) and housings (8,9), so that the housings and coils are urged into contact with the barrel by spring pressure. In another embodiment, the appts. may be adapted to a cylindrical extruder barrel.
Patients will be randomly assigned (2:1) to one of two treatment arms (the Excel DES or the Cypher DES). Randomization will be stratified by study site and number of vessels intended to be treated by the site investigator. Randomization will be accomplished through use of envelope randomization at the sites using the pre-assigned envelope randomization system. The study patient is considered enrolled upon randomization.
Purpose: Controlled, intervention trials suggest that exercise may be a useful strategy to manage symptoms and side effects associated with cancer treatment. However, practical programs that facilitate exercise engagement among cancer patients are few and have been insufficiently studied. Medical providers may be best suited to deliver exercise information because of their frequent patient contact and the trust that patients place in their advice; however, unless sufficient resources are supplied in conjunction with verbal advice, patients may be less likely to successfully follow their physician's advice. The addition of an easy-to-follow, cancer specific exercise instructional video (DVD) to a provider's recommendation to exercise may provide patients with the motivation and ability to increase physical activity. We propose a feasibility study that will 1) determine acceptance and use of a provider-disseminated instructional home-exercise DVD among female cancer patients treated at OHSU and 2) determine if this cancer specific home-based DVD exercise program leads to greater decreases in fatigue, increases in exercise motivation and in physical activity compared to a standard exercise recommendation only among breast cancer patients treated at OHSU (N=100).

Methods: Medical providers who see female cancer patients during routine clinical visits will be approached to participate in the study. Willing providers will be enlisted to consent patients to receive a brief conversation (2-3 minutes) about the importance of exercise in their cancer care and then ask whether or not patients are willing to receive more information about the study from study staff. Providers will inform study staff about consenting participants who will then be randomized to one of two groups in the order that they enrolled. Study staff will then contact participants by phone to further explain the study and confirm eligibility then ask questions about their treatment, symptoms, and physical activity history. Based on their randomly assigned group, participants will receive either a control packet of standard exercise information based on guidelines from the American Cancer Society or standard exercise information plus a cancer specific home-based exercise DVD program. Fatigue, motivation for exercise, physical activity and use / acceptability of exercise information (+/- DVD) will be reassessed at 4 and 8 weeks following enrollment.
Heterogeneity for biomarkers in a tissue sample can be calculated. A heterogeneity score can be combined with an immunohistochemistry combination score to provide breast cancer recurrence prognosis. Heterogeneity can be based on percent positivity determinations for a plurality of biomarkers according to how many cells in the sample stain positive. An immunohistochemistry combination score can be calculated. An imaging tool can support a digital pathologist workflow that includes designating fields of view in an image of the tissue sample. Based on the fields of view, a heterogeneity metric can be calculated and combined with an immunohistochemistry combination score to generate a breast cancer recurrence prognosis score.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to a pharmaceutical preparation containing an agent that blocks EPI-activity (inhibitor) as an active component and benefit preparation for treatment of patients with prolonged coagulation time. Invention relates to also a method of acceleration of blood coagulation in vitro using the claimed preparation and the use of an inhibitor of EPI-activity as a substance that is able to accelerate blood coagulation process. Preparation shows a tendency to decrease bleeding in patients. EFFECT: enhanced effectiveness of a preparation proposed. 7 cl, 4 tbl, 2 dwg
PURPOSE: A pharmaceutical composition and a food composition containing a pomegranate peel salt with whitening and anti-inflammatory effects are provided to relieve pruritus and to suppress melanogenesis and tyrosinase activities. CONSTITUTION: A pharmaceutical composition for skin whitening contains a pomegranate peel salt containing a pomegranate extract and a salt. A pharmaceutical composition for anti-inflammation contains the pomegranate peel salt as an active ingredient. A method for preparing the pomegranate peel salt comprise: a step of extracting an active ingredient from pomegranate peel and preparing a sample; a step of baking bay salt at 70-90 deg. C; and a step of mixing the sample and the baked bay salt in a ratio of 1:10(w/w). The sample is prepared by dipping pomegranate peel in 60-80% ethanol. The bay salt is matured for 2 or more years. A food composition for skin whitening and anti-inflammation contains the pomegranate peel salt as an active ingredient.
PURPOSE:To provide an antineoplastic and immunoenhancing agent containing, as active ingredient, a culture filtrate of Bacillus stearothermophilus. CONSTITUTION:Bacillus stearothermophilus as a moderately thermophilic bacterium, pref. NCA-1503 strain (FERM P-4778) is aerobically cultured in a conventional medium. The resultant culture solution is filtered or centrifuged to remove the microbial from the filtrate, which is then sterilized or put to elimination of bacterial cells, and the product is, directly or after lyophilization or concentration, used as the objective antineoplastic and immunoenhanceing agent. The object filtrate is further put to extraction and/or separation by e.g. column chromatography to obtain a compound of the formula ((n) is 3-8; R1-R2 are each alkyl, phenyl or phenylalkyl) as active ingredient, e.g. 2-(hydroxyethyl) trisulfide.
Despite a vast literature on how speech intelligibility is affected by hearing loss and advanced age, remarkably little is known about the perception of talker-related information in these populations. Here, we assessed the ability of listeners to detect whether a change in talker occurred while listening to and identifying sentence-length sequences of words. Participants were recruited in four groups that differed in their age (younger/older) and hearing status (normal/impaired). The task was conducted in quiet or in a background of same-sex two-talker speech babble. We found that age and hearing loss had detrimental effects on talker change detection, in addition to their expected effects on word recognition. We also found subtle differences in the effects of age and hearing loss for trials in which the talker changed vs trials in which the talker did not change. These findings suggest that part of the difficulty encountered by older listeners, and by listeners with hearing loss, when communicating in group situations, may be due to a reduced ability to identify and discriminate between the participants in the conversation.
Soft tissue and bone infections continue to be a serious complication in orthopedic and trauma surgery. Both can lead to a high burden for the patients and the healthcare system. Musculoskeletal infections can be induced by intraoperative contamination, bacterial contamination of open wounds or hematogenous bacterial spread. During the recent decades, advances were achieved in the understanding of pathogenesis and antibiotic resistance. Despite some progress in the diagnosis and advancing of therapeutic concepts, groundbreaking successful improvement of treatment concepts is still missing. Current therapy concepts are based on the two pillars consisting of surgical debridement with joint or bone reconstruction as well as prolonged antibiotic therapy. An improved understanding of both host and pathogen-related factors leading to treatment failure is essential in musculoskeletal infections. Therefore, this review aims to give an overview of pathogen-related pathophysiology in musculoskeletal infections. It describes defense strategies of pathogens such as (1) biofilm, its development, characteristics, and treatment options. In addition, (2) characteristics of small colony variants and (3) intracellular bacteria are highlighted. Lastly (4) an outlook for potential and promising future therapeutic strategies is provided.
PURPOSE:To separate sera quickly without giving any influence upon the inspection and measurement results of the sera by adding powders of Si, SiO2, SiC as blood clotting accelerators for separation of sera and using these by adding further protamine or its salt to these for blood contg. heparin. CONSTITUTION:Fine powder of Si, quartz (SiO2) or SiC which is thoroughly refined by rinsing by the use of detergents and further washing with refined water is put into a blood sampling tube for serum separation, and blood is added to this. After intimate mixing, the mixture is left standing for about 5min, thence it is subjected to centrifugal separation or the like, whereby serum is obtained as supernatant quickly. The resultant serum is used for various inspections without giving any adverse influence upon the results thereof. For the serum separation of human blood dosed with heparin for the prevention of clotting of blood, protamine or its salt such as sulfate is added to said clotting accelerator at an amt. of not exceeding the effective neutralizing amt. of heparin according to the amt. of the heparin in the blood, by which the serum is obtd. quickly. In this way, it lends itself quickly to emergency operations, etc.
AIM & OBJECTIVES: The study aimed to compare P1 latency and P1-N1 amplitude with receptive and expressive language ages in children using cochlear implant (CI) in one ear and a hearing aid (HA) in non-implanted ear.
METHODS: The study included 30 children, consisting of 18 males and 12 females, aged between 48 and 96 months. The age at which the children received CI ranged from 42 to 69 months. A within-subject research design was utilized and participants were selected through purposive sampling. Auditory late latency responses (ALLR) were assessed using the Intelligent hearing system to measure P1 latency and P1-N1 amplitude. The assessment checklist for speech-language skills (ACSLS) was employed to evaluate receptive and expressive language age. Both assessments were conducted after cochlear implantation.
RESULTS: A total of 30 children participated in the study, with a mean implant age of 20.03 months (SD: 8.14 months). The mean P1 latency and P1-N1 amplitude was 129.50 ms (SD: 15.05 ms) and 6.93 μV (SD: 2.24 μV) respectively. Correlation analysis revealed no significant association between ALLR measures and receptive or expressive language ages. However, there was significant negative correlation between the P1 latency and implant age (Spearman's rho = -0.371, p = 0.043).
CONCLUSIONS: The study suggests that P1 latency which is an indicative of auditory maturation, may not be a reliable marker for predicting language outcomes. It can be concluded that language development is likely to be influenced by other factors beyond auditory maturation alone.
PURPOSE OF REVIEW: The purpose of this review is to provide an updated approach to the evaluation and management of pulsatile tinnitus (PT), an uncommon but often treatable subtype of tinnitus.
RECENT FINDINGS: Secondary PT can be due to either vascular or non-vascular etiologies, including, but not limited to: neoplasm, arteriovenous malformation or fistula, idiopathic intracranial hypertension, dural venous sinus stenosis, otoacoustic etiologies (e.g., otosclerosis, patulous eustachian tube) and bony defects (e.g., superior semicircular canal dehiscence). Computed tomography (CT) and magnetic resonance imaging (MRI) imaging have comparable diagnostic yield, though each may be more sensitive to specific etiologies. If initial vascular imaging is negative and a vascular etiology is strongly suspected, digital subtraction angiography (DSA) may further aid in the diagnosis. Many vascular etiologies of PT can be managed endovascularly, often leading to PT improvement or resolution. Notably, venous sinus stenting is an emerging therapy for PT secondary to idiopathic intracranial hypertension with venous sinus stenosis. Careful history and physical exam can help establish the differential diagnosis for PT and guide subsequent evaluation and management. Additional studies on the efficacy and long-term outcome of venous sinus stenting for venous stenosis are warranted.
PURPOSE: Provided are the salts of methanesulfonic acid and their hydrates of the compound represented by the chemical structure 1 and their pharmaceutical compositions which can be used as anti-bacterial drugs. CONSTITUTION: The methanesulfonic acid salt of the compound, 7-(3-aminomethyl-4- methyloxyiminopyrrolidene-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8- naphthylidene-3-carboxylic acid, represented by the chemical structure 1, and its hydrates can be formulated for oral, non-oral and topical use as anti-bacterial drugs. The salts are made by the process containing steps of: adding dichloromethane and ethanol mixture(8/2, v/v) to the naphthylidene (the chemical structure 1), and stirring; adding methanesulfonic acid to this solution, and stirring at 0°C for 1 hour. The product, solids, is filtered and washed with ethanol. Their hydrates are made by the steps of: dissolving the salt in water-acetone mixture; evaporating the solvent under dark or dissolving the salt in water at 45°C; adding ethanol and stirring and letting the mixture settle. The hydrates used in the invention can be simply shown as 'chemical structure 1·nH2O' where n is 1¯3.
Heart failure and myocardial infarction, global health concerns, stem from limited cardiac regeneration post-injury. Myocardial infarction, typically caused by coronary artery blockage, leads to cardiac muscle cell damage, progressing to heart failure. Addressing the adult heart's minimal self-repair capability is crucial, highlighting cardiac regeneration research's importance. Studies reveal a metabolic shift from anaerobic glycolysis to oxidative phosphorylation in neonates as a key factor in impaired cardiac regeneration, with mitochondria being central. The heart's high energy demands rely on a robust mitochondrial network, essential for cellular energy, cardiac health, and regenerative capacity. Mitochondria's influence extends to redox balance regulation, signaling molecule interactions, and apoptosis. Changes in mitochondrial morphology and quantity also impact cardiac cell regeneration. This article reviews mitochondria's multifaceted role in cardiac regeneration, particularly in myocardial infarction and heart failure models. Understanding mitochondrial function in cardiac regeneration aims to enhance myocardial infarction and heart failure treatment methods and insights.
The best available embryo is at expansion grade \<4 by Gardner classification 5 days after oocyte retrieval. Patient's embryos are cultured to day 6 and transferred regardless of expansion grade. Arrested blastocysts are discarded.
Serious neurologic events, some resulting in death, have been reported with epidural injection of corticosteroids. Specific events reported include, but are not limited to, spinal cord infarction, paraplegia, quadriplegia, cortical blindness, and stroke. These serious neurologic events have been reported with and without use of fluoroscopy. The safety and effectiveness of epidural administration of corticosteroids have not been established, and corticosteroids are not approved for this use.

In patients on corticosteroid therapy subject to any unusual stress, increased dosage of rapidly acting corticosteroids before, during and after the stressful situation is indicated. Corticosteroids may mask some signs of infection, and new infections may appear during their use. There may be decreased resistance and inability to localize infection when corticosteroids are used.

Prolonged use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to fungi or viruses.

Children who are on immunosuppressant drugs are more susceptible to infections than healthy children. Chickenpox and measles, for example, can have a more serious or even fatal course in children on immunosuppressant corticosteroids. In such children, or in adults who have not had these diseases, particular care should be taken to avoid exposure. If exposed, therapy with varicella zoster immune globulin (VZIG) or pooled intravenous immunoglobulin (IVIG), as appropriate, may be indicated. If chickenpox develops, treatment with antiviral agents may be considered.

Similarly, corticosteroids should be used with great care in patients with known or suspected Strongyloides (threadworm) infestation. In such patients, corticosteroid‑-induced immunosuppression may lead to Strongyloides hyperinfection and dissemination with widespread larval migration, often accompanied by severe enterocolitis and potentially fatal gram-negative septicemia.
Patients with renal failure receiving hemodialysis experience an increased rate of skeletal muscle protein catabolism which is associated with a number of co-morbid conditions including declines in muscle mass and strength, significantly increased fall risk, and reduced quality of life (QOL. Therefore, interventions to prevent muscle loss in hemodialysis are needed. Pharmacological agents have been investigated to treat muscle loss in dialysis patients; however, many of these treatments are expensive and have undesirable side effects. As a result, low-cost interventions designed to attenuate losses in muscle mass and strength in hemodialysis patients are needed.

Beta-hydroxy beta-methylbutyrate (HMB) represents a potential low-cost nutritional intervention to attenuate muscle loss in hemodialysis patients. HMB is a metabolite of the amino acid leucine that has been shown to safely increase muscle mass in other clinical populations with prevalent muscle loss, such as the elderly, cancer, and AIDS patients primarily through reductions in skeletal muscle protein catabolism. The primary purpose of the trial is to determine if oral supplementation with HMB attenuates muscle loss, improves muscle strength, physical function, fall risk and QOL in hemodialysis patients. Alterations in protein and gene expression associated with skeletal muscle protein turnover will be measured to investigate the mechanism for changes in our primary outcomes. We hypothesize that HMB supplementation will attenuate declines in muscle size and strength in hemodialysis patients.
Peripheral inflammation could constitute a risk factor for AD. This review summarizes the research related to peripheral inflammation that appears to have a relationship with Alzheimer's disease. We find there are significant associations between AD and peripheral infection induced by various pathogens, including herpes simplex virus type 1, cytomegalovirus, Epstein-Barr virus, human immunodeficiency virus, severe acute respiratory syndrome coronavirus 2, Porphyromonas gingivalis, Helicobacter pylori, and Toxoplasma gondii. Chronic inflammatory diseases are also reported to contribute to the pathophysiology of AD. The mechanisms by which peripheral inflammation affects the pathophysiology of AD are complex. Pathogen-derived neurotoxic molecule composition, disrupted BBB, and dysfunctional neurogenesis may all play a role in peripheral inflammation, promoting the development of AD. Anti-pathogenic medications and anti-inflammatory treatments are reported to decrease the risk of AD. Studies that could improve understanding the associations between AD and peripheral inflammation are needed. If our assumption is correct, early intervention against inflammation may be a potential method of preventing and treating AD.