anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Periprosthetic joint infection after total joint arthroplasty has a large incidence, and it may often require two or more stages of revision, placing an additional burden on clinicians and patients. The purpose of this network meta-analysis is to evaluate the effect of four different preventive strategies during total joint arthroplasty on the prevention of periprosthetic joint infection.
METHODS: The study protocol was registered at PROSPERO (CRD: 42,023,448,868), and the literature search databases included Web of Science, PubMed, OVID Cochrane Central Register of Controlled Trials, OVID EMBASE, and OVID MEDLINE (R) ALL that met the requirements. The network meta-analysis included randomized controlled trials, retrospective cohort studies and prospective cohort studies with the outcome of periprosthetic joint infection. The gemtc R package was applied to perform the network meta-analysis to evaluate the relative results of different preventive strategies.
RESULTS: This network meta-analysis study included a total of 38 articles with 4 preventive strategies and negative controls. No improvement was observed in antibiotic-loaded bone cement compared with negative controls. Chlorhexidine showed the highest probability of delivering the best preventive effect, and povidone iodine had the second highest probability. Although vancomycin ranked after chlorhexidine and povidone iodine, it still showed a significant difference compared with negative controls. In addition, the incidence after applying chlorhexidine was significantly lower than that after applying negative controls and vancomycin. In the heterogeneity test between direct and indirect evidence, there was no apparent heterogeneity between them.
CONCLUSION: The study indicated that chlorhexidine, povidone iodine and vancomycin showed significant efficacy in preventing periprosthetic joint infection after total joint arthroplasty, while antibiotic-loaded bone cement did not. Therefore, more high-quality randomized controlled trials are needed to verify the results above.
Obesity, which leads to higher rates of diabetes, cancer, and heart disease, is an increasingly important public health problem. In 2000, over 78% of African American women were overweight, and over 50% were obese. Several factors can contribute to obesity, including genetics, diet, and environmental factors. Individuals who live in an environment in which it is difficult to maintain an active lifestyle are more prone to obesity. The Black Women's Health Study (BWHS) is an extensive long-term study that is gathering data from women across the country to examine the occurrence of various diseases among African American women. Using BWHS study data and specific information on participants' neighborhoods, including street layout and the presence of sidewalks, this study will determine if neighborhood environments influence the prevalence of obesity among African American women.

This study will use already-collected data on physical activity and body mass index of BWHS study participants who live in New York, Los Angeles, and Chicago; there are no additional study visits specifically for this study. A transportation and urban planning expert will compile data regarding the pedestrian environment of neighborhoods in all three cities, including the nature and density of land use, proximity to parks, presence of sidewalks, speed and volume of traffic, and street structure. Census data regarding participants' socioeconomic status will also be collected.
A prospective randomized interventional study will be conducted in the Military University Hospital Prague at the department of Anesthesiology and Intensive care. Patients indicated by the attending physician to percutaneous dilatational tracheostomy (PDTS) due to long-term need for mechanical ventilation will be randomly divided into two groups. The standard procedure group will undergo PDTS by the attending physician in the standard manner based on clinical examination and anatomical landmarks using bronchoscopic navigation. In the second group, the attending physician will additionally use ultrasound navigation during the procedure. After insertion of the guidewire, before dilation is performed, patients in both groups will be examined by ultrasound by an independent physician - the study investigator - who will verify the position of the guidewire and its relationship to the surrounding structures. In case of malposition of the guidewire (unacceptable lateral or craniocaudal), the penetration site will be adjusted and the PDTS completed.
The arm will comprise participants that receive NRT. The NRT used will be combination therapy; transdermal Nicotine patches will be combined with faster-acting oral products like gum or lozenges. The strength of nicotine patches will be from 7 to 21 mg, and for gum or lozenges, the strength will be 1-4 mg. Usage will be in the form of a daily nicotine patch and ad libitum use of the faster-acting lozenge to curb nicotine cravings. Participants will be provided with a 12-week supply of NRT.
Advances in surgical techniques and anesthetic care have resulted in a substantial reduction in peri-operative morbidity and mortality in the elderly. However, post-operative cognitive dysfunction (POCD), as well as episodic post-operative delirium, are still recognized as significant complications following surgery in the elderly. Post-operative cognitive dysfunction is characterized by impairment of memory, concentration, language, comprehension, and social integration. Conversely, post-operative delirium is characterized by intermittent, short-term impaired cognition, disorientation, and abnormalities in memory and perception, which has been shown to lead to increased morbidity and mortality, delayed functional recovery, and prolonged hospital stays. Elderly patients are particularly sensitive to the central nervous system effects of many peri-anesthetic drugs, including benzodiazepines, barbiturates, opioids, and volatile anesthetics, which may play a role in POCD and consequent patient outcomes. Randomized clinical trials have demonstrated no difference in the recovery of cognitive function between commonly used volatile anesthetic agents.

Several simple, bedside tests are available to assess cognitive function and differentiate between cognitive dysfunction and an episode of delirium. The Confusion Assessment Method (CAM) is a standardized rating of delirium that has been validated and has high inter-observer reliability. The CAM criteria are the most commonly used method for diagnosing delirium in hospitalized patients. The Mini-Mental Status Examination (MMSE) and the Abbreviated Mental Test are tools used to assess cognitive function at the bedside.

Lidocaine is one of the most commonly used sodium-channel blockers in the medical armamentarium. It has long been used for its local anesthetic and anti-arrhythmic properties, and has been studied as an adjunct to general anesthesia. While lidocaine is cardio-toxic in excessive doses, the therapeutic and toxic levels are well-documented and wide, making lidocaine a drug with a favorable safety profile. Randomized clinical trials have shown perioperative lidocaine infusions to decrease postoperative pain scores, reduce postoperative opioid requirements, shortens hospital stays, improves postoperative recovery and fatigue score when administered as an adjuvant during surgery. Lidocaine has analgesic, antihypertensive, and anti-inflammatory properties. To date, no clinical trials have been conducted to establish the relationship between lidocaine infusions and postoperative recovery, particularly cognitive function, in elderly orthopedic surgery patients. It is therefore the aim of this study to evaluate the effects of lidocaine infusion on postoperative cognitive function in elderly patients having general anesthesia for orthopedic surgery, and to assess whether intraoperative lidocaine infusion decreases postoperative opioid usage and improves recovery.
Due to the close contacts of the lesion with the neurovascular structures, in the case of skull base chordoma and mobile spine, surgery is often incomplete. On the contrary, surgery of the sacral region (for which the block excision is often possible) brings a better therapeutic outcome. Radiotherapy with high-dose supplement improves the outcomes for all these lesions.

Intratumoral hypoxia is a primary factor of radioresistance, it's known since long by radiation oncologists. \[18F\]FAZA gives an image of the hypoxic volume target. Investigators propose to increase the radioactive dose in the hypoxic volume target but in order to succeed, radiation oncologists have to precisely identify this hypoxic volume. Radiation oncologists would increase of 10% the radioactive dose that will allow us to improve local control at 3 years of 15% without any additional side effect.
Through the fairy tale heroes, beautiful woman image, mother image, independent woman image, and passive woman image are created. While Cinderella syndrome is a concept which is used to define woman who fear from being independent, Wendy syndrome describes women who acted as mother to their husbands or people close to them. The aim of this research is to examine the relationships between Cinderella Syndrome, Wendy Syndrome, attachment styles and differentiation of self in women. 521 adult women between 18 and 65 ages completed the questionnaire including Cinderella Syndrome Scale, Wendy Syndrome Scale, Three Dimensional Attachment Styles Scale and Discrimination of Self Scale. Results revealed that there is a positive and significant correlation between Cinderella Syndrome and Wendy Syndrome. Wendy Syndrome, differentiation of self and avoidant attachment variables, respectively, predicts Cinderella Syndrome in women. Wendy Syndrome is predicted by the variables of differentiation of self, Cinderella Syndrome and anxious/ambivalent attachment respectively. The study highlights predictors of Cinderella and Wendy Syndrome and makes important contributions to the relevant literature by providing a better understanding of Cinderella Syndrome and Wendy Syndrome in women.
Perfluorocyclocarbons and emulsions containing emulsified particles of these perfluorocarbons are useful is supporting life as intravascular oxygen and carbon dioxide transport agents. Stable emulsions of perfluorocarbocyclic derivatives are prepared for use as artificial bloods and perfusates for organs. Intravenously infused emulsions containing perfluorocyclocarbons such as perfluoro(methylcyclohexane), perfluoro(1,3-dimethylcyclohexane), perfluoro(decahydronaphthalene), perfluoro(decahydro-1-methylnaphthalene), perfluoro(decahydrodimethylnaphthalene), and the like, serve as intravascular oxygen and carbon dioxide transport agents. Fluorocarbon liquids are also useful as an external respiration media for transporting oxygen-carbon dioxide necessary to support intravascular respiration. Perfluorocyclocarbons have been found after intravenous emulsion infusion as artificial bloods to collect in the reticuloendothelial system (RES) of the amimal body. However, it has also been found that perfluorocyclocarbon compounds leave the RES of the animal body and certain of these compounds, e.g., perfluoro(decahydronaphthalene), leave the RES at a much faster rate than others. Furthermore, after the intravenously infused perfluorocyclocarbon emulsions function as artificial bloods, the perfluorocyclocarbons have the capability of leaving the animal body through the tissue, e.g., the lungs and skin.
Individuals at risk of heart failure and a preserved ejection fraction of at least 50% will take a baseline (at rest) cardiopulmonary exercise test (CPX) and have a baseline cardiac echocardiogram to measure myocardial deformation. CPX and echocardiograms will be repeated during exercise sessions at 6 visits over a 12 week period. A cardiac rehabilitation exercise program will also occur over 12 weeks.
Caudal block will be performed with 0.75ml/kg of 0.25% bupivacaine containing 1 mic/kg dexmedetomidine. Circumcision will be done using plastibell. Paracetamol suppository will also be inserted per rectum in the dose of 15 mg/kg before the start of surgery. The surgery will be started 10 minutes after block placement to allow adequate time for the block to be effective.
Subjects selecting hysteroscopic sterilization who are not contraindicated for the Essure procedure according to the most current approved version of the Essure IFU. Subject willing to use alternative contraception for at least 3 months post-Essure placement procedure, until a satisfactory Essure Confirmation Test is documented.
PURPOSE: The brachioradialis muscle (BRM) belongs to the lateral group of forearm muscles and contributes to the elbow flexion. Accessory brachioradialis muscle (ABRM) or "brachioradialis accessorius" represents an uncommon BRM variant, not been enough studied. The present study investigates the prevalence of the ABRM, along with its origin, insertion, and innervation.
MATERIALS: Eighty-three upper limbs were meticulously dissected at the arm, forearm, and cubital fossa to investigate the ABRM presence. When the variant muscle was identified, morphometric measurements were obtained.
RESULTS: The ABRM was identified in two upper limbs (2/83, 2.4%), in a male cadaver, bilaterally. Its origin was located along with the typical BRM, and its insertion was identified into the anterior surface of the radius (proximal third). The ABRM was innervated by the radial nerve, coursing posteriorly (deeply).
CONCLUSIONS: In the current study, the variant muscle was observed in 2.4%. Radial nerve compression, at the forearm, is not an uncommon entrapment neuropathy. The relationship between the radial nerve and the ABRM could precipitate radial neuropathy.
661,248. Cosmetic. LANOLIN PLUS COSMETICS, Inc. July 27, 1949, No. 19687/49. Class 81 (i). A fluid stable homogeneous cosmetic solution comprises from 15 to 50 per cent by weight of lanolin in isopropyl palmitate. 2 per cent waxes such as spermaceti or cetyl alcohol and 10 to 15 per cent of refined mineral oil may be added. In one example, 35 parts of lanolin are dissolved in 65 parts of isopropyl palmitate and in the other are dissolved in 53 parts of isopropyl palmitate, 10 parts of mineral oil and 2 parts of cetyl alcohol. The lanolin and waxes are dissolved at 50‹ C. the solution cooled to 45‹ C. the mineral oil added and the product rapidly cooled to 30‹ C.
FIELD: medicine, neurosurgery. SUBSTANCE: after dissecting a dura mater a relevant medullary substance should be observed through trephination opening applied in cranial arc bones with the help of castellated cutter. Suction pump is used to remove medullary detritis, then a wound is washed with medicinal solution. The same opening is used to conduct drainage of lateral ventricle and brain with polyvinyl chloride catheter which should be connected to the system of pressure control. Then an influx-reflux system of continuous inflow of liquid which contains protein-splitting enzymes should be applied into crushing focus area. EFFECT: decreased traumaticity of the method, higher efficiency to conduct correction of cerebral pressure. 2 cl, 1 dwg
Lateral lymph node metastasis (LLNM) is common in mid-low rectal cancer and is also a major cause of postoperative local recurrence. Currently, there is still controversy regarding the diagnosis and treatment of LLNM in rectal cancer. This consensus, based on the "Chinese Consensus on Diagnosis and Treatment of Lateral Lymph Node Metastasis in Rectal Cancer (2019 edition)," incorporates the latest domestic and international research findings and revises aspects related to the diagnosis, treatment strategies, follow-up, and management of recurrence of LLNM in rectal cancer. A total of 42 domestic colorectal cancer experts participated in this consensus. It proposes 18 consensus statements on the diagnosis and treatment of LLNM, using the evaluation criteria of the U.S. Preventive Services Task Force for grading recommendations. The aim is to standardize further the diagnostic criteria and treatment strategies for LLNM in rectal cancer. Unresolved issues in this consensus require further clinical practice and active engagement in high-quality clinical research to explore and address them progressively.
The current study examined spoken verb learning in elementary school children with language disorder (LD). We aimed to replicate verb learning deficits reported in younger children with LD and to examine whether verb instrumentality, a semantic factor reflecting whether an action requires an instrument (e.g., "to chop" is an instrumental verb), influenced verb learning. The possible facilitating effect of orthographic cues presented during training was also evaluated. In an exploratory analysis, we investigated whether language and reading skills mediated verb learning performance. General language skills and verb learning were assessed in Dutch children with LD and age-matched typically developing controls (n = 25 per group) aged 8 to 12 years (M = 9;9 [years;months], SD = 1;3). Using video animations, children learned 20 nonwords depicting actions comprising 10 instrumental and 10 noninstrumental verbs. Half of the items were trained with orthographic information present. Verb learning was assessed using an animation-word matching and animation naming task. Linear mixed-effects models showed a main effect of group for all verb learning measures, demonstrating that children with LD learned fewer words and at a slower rate than the control group. No effect of verb instrumentality, presence of orthographic information, or the included mediators was found. Our results emphasize the importance of continued vocabulary instruction in elementary school to strengthen verb encoding. Given that our findings are inconsistent with the overall literature showing an orthographic facilitation effect, future studies should investigate whether participants pay attention to the written word form in learning contexts with moving stimuli.
A method for predicting a patient outcome from a caretaker episode includes receiving a current episode snapshot of the caretaker episode comprising multi-modal data of the patient from an electronic health records (EHR) system, the multi-modal data including one or more available data modalities and one or more missing data modalities. The multi-modal data is applied as input to an embedding model having a submodel for each of the data modalities. A first embedding is generated for each of the available data modalities. A second embedding is generated for each of the missing data modalities using corresponding embeddings of neighbors in an episode snapshot graph. The first and second embeddings are combined to obtain a complete embedding. The patient outcome is predicted based on the complete embedding for the current episode snapshot using a machine learning component which has been trained using patient outcomes of the historical episode snapshots.
INTRODUCTION: The WHO neglected tropical disease (NTD) roadmap stresses the importance of integrating NTDs requiring case management (CM) within the health system. The NTDs programme of Liberia is among the first to implement an integrated approach and evaluate its impact.
METHODS: A retrospective study of three of five CM-NTD-endemic counties that implemented the integrated approach was compared with cluster-matched counties with non-integrated CM-NTD. We compared trends in CM-NTD integrated versus non-integrated county clusters. We conducted a pre-post comparison of WHO high-level outcomes using data collected during intervention years compared with baseline in control counties. Changes in health outcomes, effect sizes for different diseases and rate ratios with statistically significant differences were determined. Complementary qualitative research explored CM-NTD stakeholders' perceptions, analysed through the framework approach, which is a transparent, multistage approach for qualitative thematic interdisciplinary data analysis.
RESULTS: The detection rates for all diseases combined improved significantly in the intervention compared with the control clusters. Besides leprosy, detection rates improved with large effects, over fourfold increase with statistically significant effects for individual diseases (p<0.000; 95% CI 3.5 to 5.4). Access to CM-NTD services increased in integrated counties by 71 facilities, compared with three facilities in non-integrated counties. Qualitative findings highlight training and supervision as inputs underpinning increases in case detection, but challenges with refresher training, medicine supply and incentives negatively impact quality, equity and access.
CONCLUSIONS: Integrating CM-NTDs improves case detection, accessibility and availability of CM-NTD services, promoting universal health coverage. Early case detection and the quality of care need further strengthening.
Participants in this condition will receive 15 sessions (each lasting 20 minutes) over a 5-week period. This will also be home-based training over the Internet. This training will be based on a fixed 1-back training program.
The behavior stage was determined by applying the "Stages of Change Scale" (SCS) form to the pregnant women in the experimental group. The pre-test data from the women in the experimental group were obtained through the website through the Participant Introduction Form,"Behavior Change Process Scale" (BCPS), "Self-Efficacy Scale/Encouraging Factors Scale" (SES/EFS) and "Decision Balance Scale" (DBS) before watching the videos. In addition, FNDT was applied to women who smoked during pregnancy. Post-test data from the women in the experimental group were collected by having them fill out the postpartum part of the Participant Identification Form at the 4th week postpartum after watching the animation videos, and FNDT, SCS, BCPS/EFS and DBS forms for those who still smoke, on the website.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to oncology, and can be used for combined treatment of patients with stomach cancer (SC) with peritoneal carcinomatosis. It involves palliative surgical management and chemotherapy with intraperitoneal introduction of cisplatin. Chemotherapy is performed in the neoadjuvant mode according to paclitaxel 135 mg/mon 1st day intravenously drop-by-drop for 3 hours, cisplatin 50 mg on the second day intraperitoneally, paclitaxel 65 mg/min 8th day intraperitoneally. 3 courses every 21 days. 4 weeks after neoadjuvant chemotherapy, gastrectomy is performed. 3 weeks after the surgical management, adjuvant chemotherapy is performed according to the previous schedule, 3–6 courses every 21 days.EFFECT: method provides improved results of combined treatment of patients with intestinal peritoneal cancer with peritoneic sclerosis by reducing the frequency of postoperative complications and side effects of chemotherapy, improving quality of life, as well as increasing patient's survival rates.1 cl, 1 ex
PURPOSE:A peel-off type pack composition having a short drying time and good feeling in use, obtained by adding a crosslinkable water-soluble metal compound to an aqueous or water-alcohol solution of polyvinyl alcohol. CONSTITUTION:Polyvinyl alcohol (preferably one modified by an alkoxy-containing silicone compound) is dissolved in water or a mixed solvent of water and alcohol to give a solution, to which a crosslinkable water-soluble metal compound is added to prepare a pack composition. A compound of Ti, Zr, or Al is preferably used as the metal compound and 0.01-10pts.wt. of the metal compound is blended with 1 pt.wt. of polyvinyl alcohol. The prepared pack composition has improved drying characteristics and can be peeled off for only about 8-17min.
The investigators will administer the sham tACS intervention to the participants. They will use an active sham in which very low-level alternating currents (0.5 mA total) will be transferred between electrodes in close proximity on the scalp throughout the entire 20-minute session.
The test product is an oat based beverage with added vegetable oil. The test portion is based on 42 gram available carbohydrates and consumed as a breakfast meal prior to determinations of test variables in the morning.