anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A 3+3 study de-escalating dose design will be employed for dose determination. Subjects will receive treatment in 21-day cycles until disease progression, intolerable toxicities or withdrawal of consent.
Nucleosides and other compounds to selectively modulate Th1 and Th2 responses relative to each other in the treatment of disease. In one aspect of the invention, administration of a nucleoside or other compound reduces the dosage at which a primary drug is administered. In another aspect of the invention, an abnormality reflected in increased response in one group of cytokines is treated by administering a nucleoside or other compound which increases response in another group of cytokines. In yet another aspect of the invention, a patient is prophylactically treated by administering a nucleoside or other compound which selectively reduces Th1 activity without significantly reducing Th2 activity. In yet another aspect of the invention, a nucleoside or other compound is administered to a patient at a dose which reduces the patient's GTP pool to a degree that selectively reduces one of the Th1 or Th2 response without significantly reducing the other response. Controlled release dosage forms are particularly contemplated to achieve that result.
Participants randomized to condition 3 will receive the Decentering treatment component. Total number of sessions: 2 (2 contact hours).
This will be comprised of standard care they will be receiving from participating centres at recruitment sites. The standard care for individuals with SUD in Pakistan usually includes a 2-3-week detoxification programme, followed by 2 months of weekly 1:1 session along with some family sessions, followed by a period of support groups programmes.
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to functional diagnostics, somnology, public health and health care, labor physiology, chronobiology, can be used in the development of recommendations for the organization of work and rest regimes. Sex, age, and time of light exposure are determined. The corrected mean sleep phase is calculated according to the Munich Chrono-Type Questionnaire test. the predicted shift of the corrected mean sleep phase is determined according to the Munich Chrono-Type Questionnaire test. After that, the predicted shift value is added to the value of the calculated corrected mean sleep phase according to the Munich Chrono-Type Questionnaire test, and the value of the corrected mean sleep phase according to the Munich Chrono-Type Questionnaire test is obtained, which is expected with a decrease in light exposure. Next, the obtained value is assessed.EFFECT: method makes it possible to assess the expected shift in the corrected mean sleep phase according to the Munich Chrono-Type Questionnaire test when changing the time of daytime light exposure in persons with a free work schedule.1 cl, 1 tbl, 8 ex
Endothelial dysfunction (ED) is closely associated with most cardiovascular diseases. Experimental models are needed to analyze the potential impact of ED on cardioprotection in constant pressure Langendorff systems (CPLS). One cardioprotective strategy against ischemia/reperfusion injury (I/RI) is conditioning with the lipid emulsion Intralipid (IL). Whether ED modulates the cardioprotective effect of IL remains unknown. The aim of the study was to transfer a protocol using a constant flow Langendorff system for the induction of ED into a CPLS, without the loss of smooth muscle cell functionality, and to analyze the cardioprotective effect of IL against I/RI under ED. In isolated hearts of male Wistar rats, ED was induced by 10 min perfusion of a Krebs-Henseleit buffer containing 60 mM KCl (K+), and the vasodilatory response to the vasodilators histamine (endothelial-dependent) and sodium-nitroprusside (SNP, endothelial-independent) was measured. A CPLS was employed to determine cardioprotection of pre- or postconditioning with 1% IL against I/RI. The constant flow perfusion of K+ reduced endothelial response to histamine but not to SNP, indicating reduced vasodilatory functionality of endothelial cells but not smooth muscle cells. Preconditioning with IL reduced infarct size and improved cardiac function while postconditioning with IL had no effect. The induction of ED neither influenced infarct size nor affected the cardioprotective effect by preconditioning with IL. This protocol allows for studies of cardioprotective strategies under ED in CLPS. The protection by preconditioning with IL seems to be mediated independently of a functional endothelium.
Use of a Helicobacter antigen selected from the group consisting of: i) an antigen having a molecular mass of approximately 19 kDa which is processed into a mature form having a molecular mass of approximately 17 kDa, the antigen comprising an amino acid sequence substantially corresponding to the deduced sequence of clone B4.6 (SEQ ID NO. 10 - described in the specification), or allelic or other variants thereof; ii) an antigen having a molecular mass of approximately 13 kDa, the antigen comprising an amino acid sequence substantially corresponding to the deduced sequence of clone C3.5 (SEQ ID NO. 2 - described in the specification), or allelic or other variants thereof; iii) an antigen having a molecular mass of approximately 36 kDa, the antigen comprising an amino acid sequence substantially corresponding to the deduced sequence of clone E2.5 (SEQ ID NO. 4  - described in the specification), or allelic or other variants thereof; iv) an antigen having a molecular mass of approximately 50 kDa, the antigen comprising an amino acid sequence substantially corresponding to the deduced sequence of clone G3.8 (SEQ ID NO. 6 - described in the specification), or allelic or other variants thereof; v) an antigen having a molecular mass of approximately 29 kDa, the antigen comprising an amino acid sequence substantially corresponding to the deduced sequence of clone H5.1 (SEQ ID NO. 8 - described in the specification), or allelic or other variants thereof; vi) immunogenic fragments of any of the antigens (i) to (v) above which are capable of eliciting a specific protective immune response in a mammalian host; together with one or more pharmaceutically acceptable carriers and/or diluents, optionally in association with an adjuvant, in the manufacture of a composition for the treatment or prevention of Helicobacter infection in a mammalian host. Also described is the use of an antibody specific for a Helicobacter antigen (selected from I -vi above), in the manufacture of a vaccine composition for the treatment or prevention of Helicobacter infection in a mammalian host. Also described is the use of a vaccine vector expressing an isolated Helicobacter antigen (selected from i - vi above), in the manufacture of a vaccine composition for the treatment or prevention of Helicobacter infection in a mammalian host.
The method for separating the proteins of the blood comprises chromatographic purification. Cryoprecipitate of blood plasma is treated with aluminum oxide, cooled to 14-16°C, and centrifuged. The supernatant is sterilized by filtration. Then the solution is treated with detergent for virus inactivation and applied to the column packed with the resin. The buffer solution containing 0.11 m-eq. of sodium chloride is used. Fibrinogen in contrast to other proteins is not absorbed on the column. Then fibronectin and von Willebrand factor are eluted.
The importance of liver function for brain and cognitive health is undeniable. Specifically, adults with chronic liver diseases such as non-alcoholic fatty liver disease (NAFLD), a factor of metabolic syndrome (MetS), experience a range of symptoms including problems with attention, problem solving skills and executive function. Importantly, diet plays a role in the development of NAFLD. The investigators propose to be the first to demonstrate that Metabolic syndrome-related brain vulnerability, in the form of elevated free cerebral glutamate, is related to hepatic triglyceride level, through experimental manipulation of liver fat and multiorgan imaging. The investigators seek to improve liver health by altering diet content in a block randomized feeding trial. The investigators selected a low-carbohydrate (\<30 g/d) diet (LoCHO) to reduce liver fat and a low-calorie (LoCAL) diet as a control for weight loss. The investigators hypothesize that LoCHO diet will improve cognitive performance by improving liver health and thus, brain health. This work may provide a way to support brain function in MetS and delay cognitive decline.
Systems, methods, and devices are provided for responding to requests received from users in a healthcare facility, and for generating alerts based upon criticality detected in received verbal utterances. A personal assistant device (PAD) may receive a verbal request for information. The identity of the requestor may be verified and a response to the request may be received by the PAD. In some cases, prior to audibly outputting the response, it may be determined whether the response contains protected health information (PHI). Upon determining that the response contains PHI, the presence of persons other than the patient in proximity to the PAD and/or security of the location of the PAD may be evaluated prior to audibly outputting the response. Additionally, alerts having a heightened criticality may be generated when a received verbal utterance is determined to have a heightened criticality.
A 104 week dietary carcinogenicity study with ezetimibe was conducted in rats at doses up to 1,500 mg/kg/day (males) and 500 mg/kg/day (females) (~20 X the human exposure at 10 mg daily based on AUC0-24hr for total ezetimibe). A 104 week dietary carcinogenicity study with ezetimibe was also conducted in mice at doses up to 500 mg/kg/day (> 150 X the human exposure at 10 mg daily based on AUC0-24hr for total ezetimibe). There were no statistically significant increases in tumor incidences in drug-treated rats or mice. 

No evidence of mutagenicity was observed in vitro in a microbial mutagenicity (Ames) test with Salmonella typhimurium and Escherichia coli with or without metabolic activation. No evidence of clastogenicity was observed in vitro in a chromosomal aberration assay in human peripheral blood lymphocytes with or without metabolic activation. In addition, there was no evidence of genotoxicity in the in vivo mouse micronucleus test. 

In oral (gavage) fertility studies of ezetimibe conducted in rats, there was no evidence of reproductive toxicity at doses up to 1,000 mg/kg/day in male or female rats (~7 X the human exposure at 10 mg daily based on AUC0-24hr for total ezetimibe).
BACKGROUND: Chronic low-grade inflammation may mediate the relationship between obesity and diabetes, yet clinical research in this area remains scarce. Thus, this study aimed to explore the mediating role of chronic low-grade inflammation in this relationship using the National Health and Nutrition Examination Survey (NHANES).
METHODS: This study involved 2,482 participants enrolled in the NHANES between 2005 and 2016. Based on the complex sampling survey weights of NHANES, logistic regression models were fitted, adjusting for various covariates to investigate the relationship between BMI, INFLA score, and diabetes. Moreover, weighted quantile sum (WQS) regression models were fitted to analyze the proportional contribution of individual components within the INFLA score. Finally, mediation analysis was conducted to quantitatively assess the magnitude of the mediating effect of the INFLA score on the relationship between BMI and diabetes.
RESULTS: After adjusting for all potential confounding factors, a significant positive correlation was noted between INFLA score and diabetes [OR (95% CI), 1.038(1.003-1.075), p = 0.035]. Additionally, a significant positive correlation was observed between the high INFLA group and diabetes compared to the low INFLA group [OR (95% CI), 1.599(1.031-2.481), p = 0.037]. WQS regression models revealed that the proportional contributions of C-reactive protein, white blood cell count, platelet count, and neutrophil-to-lymphocyte ratio (NLR) were 55.5%, 34.8%, 8.46%, and 1.19%, respectively. Finally, the results of the mediation analysis indicated that the indirect effect of the INFLA score accounted for 10.20%.
CONCLUSIONS: Chronic low-grade inflammation was associated with diabetes and partially mediates the relationship between obesity and diabetes.
While genetic engineering has undergone rapid advancement with the discovery of CRISPR/Cas9, there is room for improvement for genetic circuit control, precision (reducing circuit ‘leakiness’) and delivery into living systems. The claimed invention offers programmable and precise regulation of dCas9 functions in response to multiple molecular signals by using synthetic gene circuits, greatly expanding applications. Moreover, using the system to greatest therapeutic potential has been greatly limited by the restrictive cargo size of existing viral delivery systems. By splitting dCas9 into multiple sections, the delivery size of synthetic gene circuits is greatly reduced. By exchanging split dCas9 domains, differential regulation on one gene, or activating two different genes in response to cell-type specific microRNAs is illustrated. Practical applications of the illustrative examples include engineered sensory switches including indicators for bladder cancer as well as enhanced systems for adenovirus delivery, cellular regulation, plant cell modification and potential therapeutic applications.
Steroids play a vital role in animal survival, promoting growth and development when administered appropriate concentration exogenously. However, it remains unclear whether steroids can induce gonadal development and the underlying mechanism. This study assessed sea cucumber weights post-culturing, employing paraffin sections and RNA sequencing (RNA-seq) to explore gonadal changes and gene expression in response to exogenous steroid addition. Testosterone and cholesterol, dissolved in absolute ethanol, were incorporated into sea cucumber diets. After 30 days, testosterone and cholesterol significantly increased sea cucumber weights, with the total weight of experimental groups surpassing the control. The testosterone-fed group exhibited significantly higher eviscerated weight than the control group. In addition, dietary steroids influenced gonad morphology and upregulated genes related to cell proliferation,such as RPL35, PC, eLF-1, MPC2, ADCY10 and CYP2C18. Thees upregulated differentially expressed genes were significantly enriched in the organic system, metabolism, genetic information and environmental information categories. These findings imply that steroids may contribute to the growth and the process of genetic information translation and protein synthesis essential for gonadal development and gametogenesis.
Semillas de Apego is a group-based psychosocial program for victimized caregivers with children 2 to 5 in Colombia, a country devastated by violence. The program's builds upon scientific evidence on (i) the way in which violence hinders early childhood development and erodes mothers' mental health and their capacity to form nurturing relationships with their children, and (ii) the effectiveness of promoting healthy child-parent attachments to mitigate the effects of toxic stress on toddlers (Lieberman and Van Horn, 2011).
Dental filling compsn. contains quartz for dimensional stability and abrasion resistance, an alpha-cyano-acrylate for sealing, and a basic catalyst which is pref. isodecylbenzene sulphonate, a mixt. of Nacl and NaCl, or Na silicate. The catalyst favours surface reactions between the quartz grains and the acrylate and produces a more homogeneous polymsn. in the mass of the compsn.
1,131,990. Carbamic esters. KNOLL A.G. CHEMISCHE FABRIKEN. 31 Dec., 1966 [3 Jan., 1966], No. 58514/66. Heading C2C. Carbamic esters of the general formula (wherein R represents a C 1-6  alkyl radical, R 1  represents a C 1-6  alkyl radical, or a phenyl group optionally carrying one or more substituents selected from halogen atoms, CF 3 , NO 2  and C 1-3  alkyl and alkoxy radicals, or R and R 1  together form a C 3-5  alkylene group, and R 2  and R 3  each represent H, a C 1-5  alkyl or hydroxyalkyl radical or a benzyl group or jointly form with N a heterocyclic residue) are prepared by reacting a compound of the general formula with a carbamic ester of a lower alkanol in the presence of a re-esterification catalyst, or with a chloroformic ester or phosgene followed by reaction of the product with a compound R 2 .NH.R 3 . Pharmaceutical compositions having a damping action on the central nervous system and which show pronounced muscle relaxing or cramp preventing effects contain as the active ingredient the above carbamic esters.
Motivational interviewing is an evidence-based counseling approach that aims to increase a patient's motivation to make positive health changes in their lives. A common training method for medical professionals is the use of human standardized patients, who are actors who pretend to be patients for educational interviews. Standardized patients are expensive and it is challenging to maintain an adequate pool of patient actors. Accordingly, after licensure or medical boards, health professionals typically adopt new evidence-based practices, like motivational interviewing, without human standardized patient training experiences. Given the established importance of post-training coaching and feedback to the acquisition of motivational interviewing, innovative training methods are needed. Computer virtual patients may provide a cost-effective alternative that is scalable and supports dissemination of evidence-based practices. This study will evaluate the efficacy of a virtual standardized patient, relative to academic study, for training motivational interviewing among health care professionals from the Department of Veterans Affairs and Department of Defense.
The present invention discloses carboxymethyl chitosan nanometer particles as a medicine carrier and a preparation method thereof. The nanometer particles basically contain the components of 12.2 to 83.3 wt% of carboxymethyl chitosan and 16.7 to 87.8 wt% of calcium chloride, and the diameter of each particle is from 200 nm to 300 nm. The preparation method has the following steps: the carboxymethyl chitosan is dissolved in distilled water; then, calcium chloride solution is added in the distilled water under a stirring condition at the room temperature to make the carboxymethyl chitosan and the calcium chloride crosslinked completely; afterwards, the carboxymethyl chitosan nanometer particles are obtained through high-speed centrifugal separation and freeze drying. Polysaccharide nanometer particles prepared under a neutrality condition can avoid the side effect of the organic solvent. Compared with the present usual method of solvent evaporation and emulsification, namely solvent diffusion, the needed energy of the nanometer particles can be reduced greatly. The cancer resistant medicine doxorubicin (DOX) is taken as model medicine, the encapsulated rate of BSA can reach 38%, the slow release takes more than three days, and the carboxymethyl chitosan nanometer particles can be used for long circulation in the body.
BACKGROUND: Liver cirrhosis is a chronic disease that is known as a "silent killer" and its true prevalence is difficult to describe. It is imperative to accurately characterize the prevalence of cirrhosis because of its increasing healthcare burden.
METHODS: In this retrospective cohort study, trends in cirrhosis prevalence were evaluated using administrative data from one of the largest national health insurance providers in the US. (2011-2018). Enrolled adult (≥18-years-old) patients with cirrhosis defined by ICD-9 and ICD-10 were included in the study. The primary outcome measured in the study was the prevalence of cirrhosis 2011-2018.
RESULTS: Among the 371,482 patients with cirrhosis, the mean age was 62.2 (±13.7) years; 53.3% had commercial insurance and 46.4% had Medicare Advantage. The most frequent cirrhosis etiologies were alcohol-related (26.0%), NASH (20.9%) and HCV (20.0%). Mean time of follow-up was 725 (±732.3) days. The observed cirrhosis prevalence was 0.71% in 2018, a 2-fold increase from 2012 (0.34%). The highest prevalence observed was among patients with Medicare Advantage insurance (1.67%) in 2018. Prevalence increased in each US. state, with Southern states having the most rapid rise (2.3-fold). The most significant increases were observed in patients with NASH (3.9-fold) and alcohol-related (2-fold) cirrhosis.
CONCLUSION: Between 2012-2018, the prevalence of liver cirrhosis doubled among insured patients. Alcohol-related and NASH cirrhosis were the most significant contributors to this increase. Patients living in the South, and those insured by Medicare Advantage also have disproportionately higher prevalence of cirrhosis. Public health interventions are important to mitigate this concerning trajectory of strain to the health system.
A preparation ( 10, 11,12,13 ) to be fixed to a natural tooth part or tooth, in particular for the replacement of a load-bearing tooth part, is for example a filling for a drilled-out tooth ( 1 ), a crown, bridge or prosthesis to be placed on a tooth stub, or a tooth pin to be fixed in a tooth root for fastening an artificial tooth, a bridge or a prosthesis. The preparation has surface regions which consist of a material with thermoplastic properties. The preparation ( 10, 11, 12,13 ) is designed in a manner such that it has oscillation properties with such low damping losses that for a liquefaction of the material with thermoplastic properties by way of oscillations there are local stress concentrations required, and in a manner such that such stress concentrations only occur in the region of the preparation surface. The preparation is positioned on a suitably prepared natural tooth part in a manner such that the material with the thermoplastic properties is in contact or may be brought into contact with the dentin surface and/or enamel surface. The preparation is then made to mechanically oscillate and is simultaneously pressed against the natural tooth part, whereby the material with the thermoplastic properties is at least partly liquefied and brought into intimate contact with the dentin or enamel surface in a manner such that after solidification it forms a positive fit and/or material fit connection. Teeth restored with such preparations have a high stability and a long life, which in particular is attributed to the fact that the thermoplastic material, in contrast to cements used for the same purpose, shrinks less and has the ability to relieve internal stress by creeping.