anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A method for preparing a nitrachlorophenol tablet and a nitrachlorophenol compound tablet belongs to the technical field of veterinary medicines, wherein the nitrachlorophenol tablet comprises 20 parts of nitrachlorophenol, 10 parts of talcum powder, 20 parts of microcrystalline cellulose, 0.5 part of magnesium stearate, 5 parts of dextrin, 2 parts of white sugar, a plurality of water and a plurality of starch. Also comprises 0.3 part of antioxidant, wherein the antioxidant is sodium bisulfite, vitamin C and formaldehyde sodium hyposulfite. Or also comprises 3 parts of complexing agent or 3 parts of metal ion compound. Or also comprises 0.5 part of polysorbate and 2.5-10 parts of soybean lecithin. Or also comprises 2.5 to 4.13 parts of sodium chloride. In addition, also provides a preparation method of the nitrachlorophenol tablet with different components. The invention solves the problem that the nitrophenol tablet changes color when being exposed to light, and simultaneously, the invention is convenient to form the nitrophenol tablet.
Certolizumab pegol binds to human TNFα with a KD of 90pM. TNFα is a key pro-inflammatory cytokine with a central role in inflammatory processes. Certolizumab pegol selectively neutralizes TNFα (IC 90 of 4 ng/mL for inhibition of human TNFα in the in vitro L929 murine fibrosarcoma cytotoxicity assay) but does not neutralize lymphotoxin α (TNFβ). Certolizumab pegol cross-reacts poorly with TNF from rodents and rabbits, therefore in vivo efficacy was evaluated using animal models in which human TNFα was the physiologically active molecule. 

Certolizumab pegol was shown to neutralize membrane-associated and soluble human TNFα in a dose-dependent manner. Incubation of monocytes with certolizumab pegol resulted in a dose-dependent inhibition of LPS-induced TNFα and IL-1β production in human monocytes.

Certolizumab pegol does not contain a fragment crystallizable (Fc) region, which is normally present in a complete antibody, and therefore does not fix complement or cause antibody-dependent cell-mediated cytotoxicity  in vitro. It does not induce apoptosis in vitro in human peripheral blood-derived monocytes or lymphocytes, nor does certolizumab pegol induce neutrophil degranulation. 

A tissue reactivity study was carried out ex vivo to evaluate potential cross-reactivity of certolizumab pegol with cryosections of normal human tissues. Certolizumab pegol showed no reactivity with a designated standard panel of normal human tissues.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects both cognition and non-cognition functions. The disease follows a continuum, starting with preclinical stages, progressing to mild cognitive and behavioral impairment, ultimately leading to dementia. Early detection of AD is crucial for better diagnosis and more effective treatment. However, the current AD diagnostic tests of biomarkers using cerebrospinal fluid and/or brain imaging are invasive or expensive, and mostly are still not able to detect early disease state. Consequently, there is an urgent need to develop new diagnostic techniques with higher sensitivity and specificity during the preclinical stages of AD. Various non-cognitive manifestations, including behavioral abnormalities, sleep disturbances, sensory dysfunctions, and physical changes, have been observed in the preclinical AD stage before occurrence of notable cognitive decline. Recent research advances have identified several biofluid biomarkers as early indicators of AD. This review focuses on these non-cognitive changes and newly discovered biomarkers in AD, specifically addressing the preclinical stages of the disease. Furthermore, it is of importance to explore the potential for developing a predictive system or network to forecast disease onset and progression at the early stage of AD.
The present invention relates to a diuresis pill which is capable of clearing toxic substances from the liver, wherein the pill is new medicine with the functions of removing blood stasis, eliminating clots, reducing swelling, detoxicating, causing diuresis, etc. The present invention is pure traditional Chinese medicine preparation using natural Chinese herbal medicine as raw materials for curing diseases such as hepatosplenomegaly, pain of liver cancer, poor appetite, primary and secondary liver cancer, various hepatitis, etc. The present invention doesn't have any chemosynthesis medicine and is suitable for diseases such as hepatosplenomegaly, pain of liver cancer, poor appetite, primary and secondary liver cancer, various hepatitis, etc. Moreover, the present invention has the characteristics of good therapeutic effect, obvious effect, convenient administration and no toxic or side effect. The present invention has conspicuous curative effects by clinical verification of multiple years. The present invention effectively removes pain of lots of patients and has favorable comment from lots of patients.
Patients in this arm will receive transcatheter arterial infusion of chemotherapy with gemcitabine and oxaliplatin every 2 weeks, until progression of disease or adverse effects leading to treatment termination. Each 4-week period is one cycle of treatment.
Globally, nurses are the largest workforce in the healthcare system that are directly engaged in the provision of newborn care. They should be conversant and competent in neonatal resuscitation. However, the majority of nurses are not skillful in the respective field. The situation is not very different when we are talking about nursing students. Who are our future workforce, hence are found incompetent in emergency newborn management and neonatal resuscitation. It is well documented that effective educational programs in preservice settings such as schools of midwifery, nursing, and medicine, established more active forms of lifelong learning to improve the quality of care. While the transformation of theoretical knowledge into clinical practice requires effective teaching in the field of resuscitation is a vital element for all undergraduate students. However, like many other developing countries in Pakistan, mostly traditional methods are following in nursing education. While the traditional method of teaching is insufficient to meet the educational demands of nursing students in clinical practice. Hence, Nursing students often are unprepared and lacking confidence in simple, yet life-saving procedures such as neonatal resuscitation. Therefore, incorporating an effective model and framework in nursing education is needed that could enhance nursing students' skills and improve clinical outcomes. The "Learn, See, Practice, Prove, Do, and Maintain" (LSPPDM) pedagogy is one of such frameworks synthesized after intensely reviewing the literature. This framework is acting as a guiding path for educators in teaching and learning procedural skills. As Knowledge is considering a prerequisite for competence in skill performance and to evaluate the effectiveness of an educational program self -efficacy measurement is an important tool. Thus, the important variables knowledge, self-efficacy, and skill have been selected for this study. Thus, the study objective will be:

To compare the knowledge, skill, and self-efficacy among undergraduate nursing students learning of neonatal resuscitation through "Learn, See, Practice, Prove, Do, Maintain pedagogy" as compared to those who will learn through the traditional method.

This study will contribute essentially to determine the effectiveness of an adapted pedagogical framework in the teaching and learning of neonatal resuscitation skills, especially in a resource-limited society. Moreover, the study findings will help the organization to develop strategies for improving nursing education.
The invention discloses a traditional Chinese medicine composition for growing and blackening hair, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 1 part of ginseng, 2-3 parts of angelica, 7-10 parts of mulberry twig, 5-6 parts of prepared rhizome of rehmannia, 7-10 parts of rhizoma drynariae, 2-3 parts of safflower and 3-5 parts of ligusticum wallichii. The invention also provides a preparation method and application of the hair growth and blacking traditional Chinese medicine composition. The technical scheme of the invention directly acts on the scalp in a transdermal drug delivery mode, so that the drug enters the systemic circulation through the skin in a constant rate or a mode close to the constant rate to generate the treatment effect. Can avoid liver first pass effect, and overcome adverse reaction caused by high blood concentration due to rapid drug absorption. And the medicine can be continuously administered, so that the risks of side effects and anaphylactic reactions generated after the medicine is taken are obviously reduced, the functions of liver and kidney are effectively improved, qi and blood are full, and good effects of preventing alopecia, growing hair and blackening hair are achieved.
PURPOSE: Traditionally, an omental flap is employed to reduce the risk of recurrence of vesicovaginal fistula (VVF) repair. In this study, we employed a modified surgical technique wherein the vaginal defect was closed using Connell sutures, without incorporation of an omental flap, aiming to mitigate potential complications.
MATERIAL AND METHOD: Between 2010 to 2018, the current randomized clinical trial was conducted on 52 women who were candidates for open fistula repair. The patients were randomly allocated into two groups. In one group, the conventional method of fistula repair was performed involving an omental flap, while in the other group, we used a modified approach with a variation in the vaginal wall closure technique. In-hospital variables, including the length of surgery, hospital stay, and occurrences of ileus, were recorded. Patient follow-up extended for one year, with assessments conducted one, six, and twelve months postoperatively. These evaluations encompassed pad test to ascertain success rates and identify any potential complications.
RESULTS: The final analysis comprised 49 patients, with an average age of 46.5 years. Baseline characteristics were comparable between the two groups (P-values > 0.05). The modified technique was associated with significantly reduced surgical duration (P = ˂ 0.001), and shorter hospital stays (P < 0.001). Ileus occurrence was reduced, but it was not significant(P = 0.856). However, the success rate showed no significant difference between the groups, with a success rate of 100% for the modified technique compared to 91.6% for the classic O'Conner method (P = 0.288).
CONCLUSION: Based on the findings of this study, vaginal wall closure using Connell sutures during VVF repair demonstrates a success rate equivalent to the classic approach involving an omental flap. Moreover, this technique presents a reduced incidence of adverse effects, along with decreased surgical duration, hospital stay, and postoperative ileus.
Carcinogenesis: Zolpidem was administered to mice and rats for 2 years at oral doses of 4, 18, and 80 mg base/kg. In mice, these doses are approximately 2.5, 10, and 50 times the maximum recommended human dose (MRHD) of 10 mg/day (8 mg zolpidem base) on mg/m2 basis. In rats, these doses are approximately 5, 20, and 100 times the MRHD on a mg/m2 basis. No evidence of carcinogenic potential was observed in mice. In rats, renal tumors (lipoma, liposarcoma) were seen at the mid- and high doses.

Mutagenesis: Zolpidem was negative in in vitro (bacterial reverse mutation, mouse lymphoma, and chromosomal aberration) and in vivo (mouse micronucleus) genetic toxicology assays.

Impairment of fertility: Oral administration of zolpidem (doses of 4, 20, and 100 mg base/kg/day) to rats prior to and during mating, and continuing in females through postpartum day 25, resulted in irregular estrus cycles and prolonged precoital intervals at the highest dose tested. The no-effect dose for these findings is approximately 24 times the MRHD on a mg/m2 basis. There was no impairment of fertility at any dose tested.
The invention discloses an external multi-functional ointment for clearing away heat and toxic materials, which is prepared by vaseline, camphor, borneol, menthol and boric acid. The external multi-functional ointment for clearing away the heat and the toxic materials has the functions of promoting the blood circulation, relieving the stasis of blood, dredging the stagnation, restoring the menstrual flow, alleviating pains, changing the blood supply of the periphery of an affected part and enhancing the regeneration of the injured face of a wound. The healing of the wound can be quickly promoted, and the function of growth is also promoted by means of medicines. The external multi-functional ointment for clearing away the heat and the toxic materials has the actions of resisting inflammation, relieving swellings, sterilizing, alleviating pains, relieving itching, clearing away toxic materials, promoting the blood circulation, relieving the stasis of blood, converging and the like. The clinical healing time of the injured face of the wound can be shortened. The external multi-functional ointment for clearing away the heat and the toxic materials also has the characteristic of preventing the occurrence of scars. To various classes of traumas which are not healed for a long time, the healing period can be shortened by 1/5, and a traditional concept of healing injury in the sinews or bones after 100 days is broken. The external multi-functional ointment for clearing away the heat and the toxic materials has an obvious curative effect to various classes of traumas or wounds which are not healed after operation, incision infection after operation and wounds with delayed healing and is especially suitable for a patient with traumatic injury. The curative effect is definite, the effect of acting is quick, the stability is strong, the pain of the patient is little, and the expense is low. The external multi-functional ointment for clearing away the heat and the toxic materials has no sequela, anaphylactic reaction and toxic or side effect after healing. The effective rate reaches 99 percent, and the cure rate reaches more than 96 percent.
The invention discloses a china cryptoporus sinensis and application thereof. The bacterial strain is China cryptoporus sinensis Liuzh2009-7523CGMCC No.3575. The new bacterial strain provided by the invention has multiple functions as resisting histamine release, restraining the growth of a plurality of tumor cells and various allergic reactions and treating pain and inflammation. At the aspects of resisting the histamine release and restraining the growth of a plurality of tumor cells, the effect of the bacterial strain or the extract of leavening thereof is better than the effect of the positive control group. Moreover, the method of culturing the China cryptoporus sinensis CGMCC No.3575 has the advantages of simple operation, low cost and high yield and the yield of active extract can reach 1.5 percent (by the solid culture medium dry weight ). Therefore, the bacterial strain, the bacterial strain leavening and the extract of the leavening have wide application foreground.
Patient (adults aged ≥18 years) with mild or moderate COVID-19 and flu-symptoms onset within 72 hours prior to inclusion. Treatment begins at the hospital. On the 4th day, participants who are well will be discharged and continue treatment up to Day 10 at home. All participants will receive Codivir 20 mg SC 2 x daily.
Cardiac surgery is a recommended therapeutic option as a form of secondary prevention for the treatment of cardiovascular diseases, but may present postoperative alterations such as reduction of pulmonary volumes and flows, impairment in gas exchange and increase in the rate of pulmonary complications. The use of positive pressure may reduce these complications. Objective: To evaluate the efficacy of positive expiratory pressure (PEP) in the blow-bottle device compared to expiratory positive airway pressure (EPAP), both associated with conventional physiotherapy, and conventional physiotherapy in the pulmonary function in postoperative cardiac patients. Methods:This is a randomized clinical trial, with patients in postoperative cardiac surgery. On the first day of postoperative, the patients will be randomized into three groups: 1 group that will receive positive expiratory pressure with blow-bottle device associated with conventional physiotherapy; 2- group that will receive positive expiratory pressure in the airways with valve unidirectional therapy associated with conventional physiotherapy; 3- group that will only receive conventional physiotherapy. The intervention of the positive expiratory pressure with blow-bottle device group will consist of exercise with a blow-bottle device of 10 cm high; the positive expiratory pressure in the airways group, exercise with unidirectional positive expiratory pressure valve (10cmH2O). Both the groups will perform three sets of 10 repetitions per day, by the third day of PO. The third group will receive conventional physiotherapy of intensive care unit. The outcomes evaluated will be: pulmonary function (primary), respiratory muscle strength, pulmonary complications, radiological changes and length of stay (at the Intensive CareUnit - ICU - and hospital). Assessment of pulmonary function, muscle strength and radiological changes will be performed in the preoperative period, prior to the interventions and on the third postoperative day, immediately prior to discharge of cardiac intensive care unit. Pulmonary complications and ICU length of stay will be recorded after discharge from intensive care unit cardiac. The length of hospital stay was recorded after hospital discharge.
This study aimed to identify quantitative biomarkers of motor function for cerebellar ataxia by evaluating gait and postural control using an RGB-depth camera-based motion analysis system. In 28 patients with degenerative cerebellar ataxia and 33 age- and sex-matched healthy controls, motor tasks (short-distance walk, closed feet stance, and stepping in place) were selected from a previously reported protocol, and scanned using Kinect V2 and customized software. The Clinical Assessment Scale for the Assessment and Rating of Ataxia (SARA) was also evaluated. Compared with the normal control group, the cerebellar ataxia group had slower gait speed and shorter step lengths, increased step width, and mediolateral trunk sway in the walk test (all P < 0.001). Lateral sway increased in the stance test in the ataxia group (P < 0.001). When stepping in place, the ataxia group showed higher arrhythmicity of stepping and increased stance time (P < 0.001). In the correlation analyses, the ataxia group showed a positive correlation between the total SARA score and arrhythmicity of stepping in place (r = 0.587, P = 0.001). SARA total score (r = 0.561, P = 0.002) and gait subscore (ρ = 0.556, P = 0.002) correlated with mediolateral truncal sway during walking. These results suggest that the RGB-depth camera-based motion analyses on mediolateral truncal sway during walking and arrhythmicity of stepping in place are useful digital motor biomarkers for the assessment of cerebellar ataxia, and could be utilized in future clinical trials.
BACKGROUND: Vascular transplantation is an effective treatment for severe vascular lesions. The design of the bioactive and mechanical properties of small-caliber vascular grafts is critical for their application in tissue engineering. In this study, we sought to develope a small-caliber vascular graft by electrospinning a mixture of a human acellular amniotic membrane (HAAM) and polycaprolactone (PCL).
RESULTS: Mechanical tests showed that the vascular grafts were strong enough to endure stress from adjacent blood vessels and blood pressure. The biocompatibility of the HAAM/PCL vascular grafts was evaluated based on cell proliferation in vitro. The tubular formation test demonstrated that vascular grafts containing HAAM could improve human umbilical vein endothelial cell function, and in vivo implantation was performed by replacing the rat abdominal aorta. The HAAM/PCL vascular graft was found to promote attachment and endothelial cell retention. The regenerated smooth muscle layer was similar to native arteries' smooth muscle layer and the endothelium coverage was complete.
CONCLUSIONS: These results suggest that our constructs may be promising vascular graft candidates and can potentially be used to develop vascular grafts that can endothelialize rapidly in vivo.
People with lower income face barriers to managing chronic diseases, such as food, housing, and economic insecurity, resource scarcity, and uncertainty around what foods meet dietary needs. Medically tailored groceries (MTG) address some barriers by providing direct access to food tailored to manage a patient's medical condition. Food resource coaching (Coach) can also address additional barriers. A food resource coach supports a patient in learning healthy eating habits when faced with financial challenges by leveraging all available food resources. For example, a coach may teach the patient how to meal plan and shop at nearby stores to improve eating patterns. Providing medically tailored groceries and food resource coaching (MTG + Coach) concurrently through a free community food market may address multiple barriers to nutrition promoting behavior change and maximize the long-term potential of Food is Medicine interventions. In this study, the investigators will recruit and enroll 200 patients of a local safety-net health center with at least one diet-related chronic condition in a randomized controlled trial. Patients will be screened for chronic diseases and income eligibility at the clinic and invited to enroll if eligible. Those who enroll will be randomized to receive MTG + Coach from a free co-located food market for 4 months (intervention) or free food from the market for 4 months (control). MTG + Coach will meet individually with a food resource coach to select MTG from the market inventory of nutritious options, discuss goals related to food and finances, and receive resources for budget management. Control can select the same amount of food from the market but will not receive tailored recommendations or interact with a coach. Feasibility, adherence, and nutritional quality of foods selected will be assessed with administrative data collected by the study team and market. Nutrition security and diet quality will be assessed with pre- and post-questionnaires. Pre- and post- qualitative interviews (N=40) will be conducted to solicit feedback on linkage to supportive services via the medical system and MTG + Coach. MTG + Coach may provide a sustainable approach to address nutritional needs of patients with lower income as patients can utilize strategies from coaching and make MTG selections from the market after the study ends. Findings will inform a larger and longer study that assesses changes in cardiometabolic outcomes.