anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A dermal application form is disclosed for prostacycline derivatives having the formula (I), in which R1? is hydrogen or alkyl having 1-10 C atoms, A is a -CH2?-CH2?-, trans-CH=CH- or -C=C- group, W is a free hydroxymethyl group or a hydroxymethyl group functionally transformed at the hydroxy group, the OH group being in the $g(a) or $g(b) position, X is a CH2? group or an oxygen atom, Z is hydrogen or a cyano group, D is a straight chain or branched saturated alkylene group having 1-5 C atoms, E is a -C=C- bond or a direct bond, R2? is a straight or branched chain, saturated alkyl group having 1-7 C atoms, R3? is a free or functionally transformed hydroxy group, and, if R1? represents a hydrogen atom, its salts with physiologically compatible bases. This application form is used to treat ulcerations caused by embolism-linked diseases, and other skin diseases.
719,886. Therapeutic substance from amniotic liquid. THOMAS, A. J. P. J., and THIERY, J. P. July 15, 1952 [July 24, 1951; July 3, 1952], No. 17883/52. Class 81(1) A liquid having valuable biological properties is prepared from amniotic liquid by removing suspended solids, deproteinizing at room temperature, - preferably by foaming, passing over an adsorbent until the liquid no longer gives a precipitate with sulphosalicylic acid and sterilizing at room temperature. As shown, amniotic liquid is centrifuged in a turbo filter comprising a covered tank 1 and a centrifuge bowl with vertical walls 2 of a filter material. The centrifugate containing much foam flows into a receiver 7 wherein the foam 8 is destroyed by gas jets 9 and protein scum is removed through the removable lid 12. The deproteinized liquid flows into a vessel 14 in the bottom of which is a layer of absorbent 15 for polypeptides, e.g. active carbon, and then into a collecting tank 17. Prior to filling into, e.g. ampoules, the liquid is passed through a bacteria-proof filter. Alternatively, the sterile liquid may be dried by lyophilization. Foaming may also be brought about by bubbling through the liquid filtered air, nitrogen, carbon dioxide gas or oxygen. Defoaming may be by means of a defoaming agent. The pH of the liquid is maintained at pH 7.0 by the addition of buffers. Sterilization may be by ultra-violet irradiation. Optionally, prior to the adsorbent treatment, the liquid may be subjected to fractional defreezing.
BACKGROUND: Ethylene oxide (EO) is a volatile compound positively correlated with respiratory and cardiovascular diseases. Currently, evidence suggests that environmental exposure may contribute to depressive symptoms. This study evaluated the correlation between EO exposure and depressive symptoms and investigated whether inflammatory indicators had a mediation effect on this correlation.
METHODS: Patients were enrolled from the National Health and Nutrition Examination Survey during 2013-2016, and 2,764 (49.67% male and 50.33% female) participants were ultimately included. EO exposure was determined by measuring hemoglobin-EO adduct (Hb-EO) concentration due to its long half-life, which was log2-transformed. Depressive symptoms were assessed using the Patient Health Questionnaire-9. Multivariable logistic regression analysis was performed to identify any correlations before and after covariate adjustment. Sensitivity analysis, subgroup analyses, and interaction tests were performed to further evaluate identified correlations. Mediation analysis was conducted to reveal whether specific inflammatory indicators mediated the correlation.
RESULTS: A high prevalence of depressive symptoms was observed in quartiles with increased levels of EO exposure, and male individuals exhibiting higher Hb-EO levels than female individuals. A positive correlation was observed between EO exposure and depressive symptoms (odds ratio [OR]: 1.439, 95% confidence interval [CI]: 1.310, 1.581), which remained stable even after covariate adjustment (OR: 1.332, 95% CI: 1.148, 1.545). Interaction tests showed significant effects of sex (p < 0.001) and thyroid diseases (p = 0.048) on this correlation. In the mediation analysis, white blood cell (p = 0.010) and neutrophil counts (p = 0.010) exerted a mediating effect, accounting for 13.6 and 11.9%, respectively.
CONCLUSION: Increased exposure to EO is associated with an elevated risk of depressive symptoms, where white blood cell and neutrophil counts exert a significant mediating effect. Further prospective studies are required to investigate the potential link among EO, other environmental pollutants, and human mental health.
INTRODUCTION: Intermuscular hydatid cyst is one of the rarest types of hydatid cyst, and as far as we know, only nine cases were reported in the literature before this study.
CASE PRESENTATION: We present a 10-year-old Iranian child with an intermuscular cystic mass in the medial-distal thigh. Despite the typical imaging findings, the patient's serological and hematological tests were negative for hydatid cyst. The cyst underwent wide excision accompanied by neoadjuvant and adjuvant chemotherapy with Albendazole. No evidence of recurrence was detected during the one-year follow-up.
CONCLUSION: Hydatid cysts should always be considered in the differential diagnosis of soft tissue cystic masses in endemic areas, and aspiration or drainage should be avoided as much as possible, even when serological tests are negative and imaging is non-diagnostic. In cases where the diagnosis of a hydatid cyst has been confirmed before the surgery, it is recommended to approach the cyst, like a tumor with chemotherapy using Albendazole both before and after wide cyst excision.
Patients will receive IV Ibuprofen 10 mg/kg to a maximum of 400 mg intravenously over 15 minutes. This medication will be diluted as per manufacturer instructions with 100 ml normal saline.
Metoprolol tartrate and hydrochlorothiazide tablets contain hydrochlorothiazide which can cause hypokalemia and hyponatremia. Hypomagnesemia can result in hypokalemia which may be difficult to treat despite potassium repletion. Monitor serum electrolytes periodically.

Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides.

Hydrochlorothiazide reduces clearance of uric acid and may cause or exacerbate hyperuricemia and precipitate gout in susceptible patients.

Hydrochlorothiazide decreases urinary calcium excretion and may cause elevations of serum calcium. Monitor calcium levels.
While many factors contribute to the success or failure of antiretroviral therapy for HIV, among the most important are factors that influence adherence to a treatment regimen, such as duration of therapy, dosing frequency, pill burden, side effects, and patient behaviors. Inconsistent adherence or nonadherence to antiretroviral therapy can result in suboptimal drug exposure. Suboptimal drug exposure can, in turn, impact short- and long-term patient outcomes by increasing the likelihood of drug resistant HIV mutants and subsequent virologic and clinical failure. It is therefore essential to design treatment regimens that promote long-term adherence to potent antiretroviral therapy. This study will evaluate the relative contribution of reduced-frequency dosing and directly observed therapy on the magnitude and durability of virologic suppression in patients treated with potent antiretroviral therapy.

Patients will be randomly assigned to one of three study arms. Arms A, B, and C receive the same daily dosage of lopinavir/ritonavir (LPV/r), emtricitabine (FTC), and stavudine extended release (d4T XR) or tenofovir DF (TDF). In Arm A, drugs are self-administered for 48 weeks; LPV/r is taken twice daily and FTC and d4T XR or TDF once daily. In Arm B, all drugs are self-administered once daily for 48 weeks. In Arm C, drugs are taken once a day under directly observed therapy during Weeks 0-24, and then by self-administration during Weeks 25-48. Adherence to the regimen is measured using an electronic drug monitoring system. Viral load, CD4 and CD8 T cell responses, population pharmacokinetics, and quality of life indicators are measured throughout the study. The tolerability and safety of the treatment regimens are also monitored.
PURPOSE:An adhesive application pharmaceutical, prepared by incorporating a rubber type adhesive material with a drug active constituent and leaves of a majoram and nutmeg, and having improved stability of the drug active constituent by the synergistic action thereof. CONSTITUTION:An adnesive application pharmaceutical prepared by incorporating a rubber type adhesive material, e.g. a natural rubber, synthetic rubber, and further the third constituent, e.g. a tackifier on an adhesion and holding power adjusting agent, etc. and a drug active constituent and leaves of a majoram or an extract thereof and nutmeg or an extract thereof. The amount of the leaves of the majoram and nutmeg to be incorporated based on the weight of the adhesive material is 0.1-20wt%, preferably 0.5-5wt%, in the case of the leaves of the majoram and nutmeg, and 0.01-5wt%, preferably 0.02-2wt%, expressed in terms of a dried material, in the case of the extract. A compound containing a phenolic hydroxyl group, e.g. a salicyclic acid derivative or an amine type compound, e.g. an ethanolamine type antihistaminic agent, used as the drug active constituent is particularly effective.
AIMS: The aim of this study was to investigate the impact of three single nucleotide polymorphisms (SNPs) within X-Ray Repair Cross Complementary Group 2 (XRCC2) gene and additional gene- abdominal obesity (AO) interaction with endometrial carcinoma (EC) risk.
METHODS: Hardy-Weinberg equilibrium was tested for all participants by using SNPstats (online software: http://bioinfo.iconcologia.net/SNPstats). The best SNP-SNP and gene-AO interaction combination among three SNPs within XRCC2 gene and AO was screened using generalized multifactor dimensionality reduction (GMDR).
RESULTS: We employed the logistic regression analysis showed that rs718282-T allele is associated with increased EC risk, adjusted ORs (95%CI) were 1.67 (1.23-2.04). However, we did not find statistical association between rs3218536, and rs3218384 and EC susceptibility. GMDR analysis was used for SNP-SNP- and gene-abdominal obesity analysis. The cross-validation consistency and the testing accuracy for the interaction were calculated. The two-locus model between rs718282 and AO had a testing accuracy of 60.11%, which was significant at the p < .001 level, and this two- locus model was considered as the best model. It provided statistical evidence for rs718282 gene-AO interaction effects. The results indicated that AO influenced the EC risk depending on the rs718282 genotypes. Compared with non- AO subjects with rs718282-CC genotype, AO subjects with rs718282-CT or TT genotype had the highest EC risk, OR (95%CI) was 2.83 (1.67 - 4.02), after covariates adjustment.
CONCLUSIONS: Both the rs718282- T allele, and its interaction with AO were associated with increased EC risk.
AIM: To clarify the role of Eomesodermin (EOMES) to serve as a disease-relevant biomarker and the intracellular molecules underlying the immunophenotype shifting of CD4+T subsets in amyotrophic lateral sclerosis (ALS).
METHODS: The derivation and validation cohorts included a total of 148 ALS patients and 101 healthy controls (HCs). Clinical data and peripheral blood were collected. T-cell subsets and the EOMES expression were quantified using multicolor flow cytometry. Serum neurofilament light chain (NFL) was measured. In 1-year longitudinal follow-ups, the ALSFRS-R scores and primary endpoint events were further recorded in the ALS patients of the validation cohort.
RESULTS: In the derivation cohort, the CD4+EOMES+T-cell subsets were significantly increased (p < 0.001). EOMES+ subset was positively correlated with increased serum NFL levels in patients with onset longer than 12 months. In the validation cohort, the elevated CD4+EOMES+T-cell proportions and their association with NFL levels were also identified. The longitudinal study revealed that ALS patients with higher EOMES expression were associated with higher progression rates (p = .010) and worse prognosis (p = .003).
CONCLUSIONS: We demonstrated that increased CD4+EOMES+T-cell subsets in ALS were associated with disease progression and poor prognosis. Identifying these associations may contribute to a better understanding of the immunopathological mechanism of ALS.
Biliary tract carcinoma account for about 3% of all digestive system tumors, with potential high metastasis and invasion ability. Their early clinical symptoms lack specificity, and they are often found in late stage with poor prognosis. CIN results from errors in chromosome segregation during mitosis, leading to structural and numerical chromosomal abnormalities. It will generate genomic heterogeneity that acts as a substrate for natural selection. Furthermore, it is proved that tumors with aneuploidies and polyploidy resulting from whole-genome doubling are related with metastasis, treatment resistance, and decreased overall survival. It is estimated that 60%-80% of human tumors exhibit chromosomal abnormalities suggestive of CIN. CIN positively correlates with tumor stage and is enriched in relapsed as well as metastatic tumor specimens. Due to the ubiquity of CIN in cancer cells, it is a potentially way to detect CIN in the cast-off cells from the bile samples for diagnosing and monitoring biliary tract carcinoma patients. BileCAD is a new method to detecting CIN in the DNA sample from patients, including extracting DNA from bile, analyzing DNA by low-coverage whole-genome sequencing, processing the data by bio-information techniques, and finally optimizing the management of biliary tract carcinoma patients.The investigators intended to conduct a prospective study by analyzing bile samples from gallbladder cancers and cholangiocarcinoma patients and control groups that without any tumor in the Bile duct and gallbladder or other organs to compare the specificity and sensitivity of BileCAD test for diagnosing biliary tract carcinoma to other modalities, such as pathological diagnosis. At the same time, the consistency of BileCAD microbial analysis results and clinical microbial culture results was compared, so as to provide more reference for clinical diagnosis.
PURPOSE: To prevent the air and an ink from reversely flowing to an ink reservoir by constituting by an intermediate member disposed between first and second conduits, and a spherical ink flow controller having a smaller diameter than that of the second conduit. CONSTITUTION: A control unit 40 has a second conduit 48 for constituting a first ink passage 49 having a diameter D1 , and the passage 49 communicates with a second ink passage 56. A spherical flow control member of a ball 80 is disposed in the passage 49. The ball 80 has a smaller diameter D2 than that D1 of the passage 49. Regarding the passage 56, the diameter D2 of the ball 80 is smaller than a width W1 but larger than a height H1 of the passage 56. The ball 80 maintains a freely floating state in the passage 49. When a negative pressure in an ink reservoir 47 invades the air into a cartridge, the ink is exhausted reversely from a supplying/printing apparatus. As a result, the ink and the air start to move reversely toward the reservoir 47. When this occurs, the ball 80 is moved in a direction of a central part 62 and toward interior by the ink.
FIELD: pharmacy, oncology. SUBSTANCE: invention proposes new agent for oncological sicknesses treatment. Agent is a complex of organocobalt (III) with Schiff's tridentate bases of the general formula (I)  . This compound enhances effectiveness of the known methods of antitumor therapy and ensures to decrease dosage of cytopathic drugs significantly or intensity of physical effects. EFFECT: enhanced effectiveness of agent. 6 tbl
PURPOSE:To stabilize a solution of an easily oxidizable substance, by filling the solution in a specific container, stoppering the container and nearly completely removing oxygen in the container. CONSTITUTION:A solution 2 of an easily oxidizable substance (e.g. water-soluble azulene, ascorbic acid, tocopherol, etc.) is filled in an oxygen-permeable plastic container 3 (made of polyethylene, polypropylene, polycarbonate, etc.) and the container 3 is put into an oxygen-impermeable enclosure 1 (e.g. aluminum foil, aluminized polyvinyl alcohol film or their composite film) together with a disoxidation agent 4 (composed mainly of iron and iron compound). The residual oxygen in the solution 2 of the easily oxidizable substance and in the space of the oxygen-permeable plastic container is almost completely transferred to the space in the oxygen-impermeable enclosure 1 and absorbed to the disoxidation agent 4. Consequently, the oxidization of the easily oxidizable substance with oxygen can be prevented and the subtance can be stored stable over a long period.
The EXERT trial is a single-center, prospective, two-armed, phase II randomized controlled trial designed to test the preliminary efficacy of exercise training in this clinical setting and to further evaluate its feasibility and safety. Participants will be 60 rectal cancer patients scheduled to receive long-course NACRT followed by total mesorectal excision. Participants will be randomly assigned to exercise training or usual care. Participants in the exercise training group will be asked to complete three supervised, high-intensity interval training sessions/week during NACRT and ≥ 150 min/week of unsupervised, moderate-to-vigorous-intensity, continuous exercise training after NACRT prior to surgery. Participants in the usual care group will be asked not to increase their exercise from baseline. Assessments will be completed pre NACRT, post NACRT, and pre surgery. The primary endpoint will be cardiorespiratory fitness (VO2 peak) at the post-NACRT time point assessed by a graded exercise test. Secondary endpoints will include functional fitness, quality of life, and symptom management. Exploratory clinical endpoints will include treatment toxicities, treatment completion, treatment response, and surgical complications.
There is limited clinical experience with XCOPRI overdose in humans. 

There is no specific antidote for overdose with XCOPRI. In the event of overdose, standard medical practice for the management of any overdose should be used. An adequate airway, oxygenation and ventilation should be ensured; monitoring of cardiac rate and rhythm and vital signs is recommended. A certified poison control center should be contacted for updated information on the management of overdose with XCOPRI. There are no data on the removal of XCOPRI using dialysis.
Single-port (SP) robotic surgery is a novel technology, and although there is emerging data, it remains limited in assessing single-port (SP) robot-assisted surgery as an alternative to multi-port (MP) platforms. To compare perioperative and postoperative outcomes between SP and MP robotic technologies for radical nephrectomy (RN). This is a retrospective cohort study of patients who have undergone robot-assisted radical nephrectomy using either the SP or MP technology. Baseline demographics, clinical, tumor-specific characteristics, and perioperative and postoperative outcomes were compared using χ2, t-test, Fisher exact test, and Mann-Whitney U test. Multivariable analyses were conducted using robust, Poisson, and logistic regressions. A total of 341 patients underwent robotic RN with 47 patients (14%) in the SP group. The two groups exhibited similar baseline characteristics, with no significant differences in age, sex, body mass index, Charlson comorbidities index, and tumor laterality. However, SP group had a smaller average tumor size (5.1 cm vs 6.4 cm, p = 0.009). The SP had longer operative time (178 ± 84 min vs 142 ± 75 min; p = 0.011) but showed no significant difference in the estimated blood loss, blood transfusion rate, length of stay, overall 30-day and major complication rates. Controlling for other variables, SP was significantly associated with a longer operative time and shorter length of stay. SP is associated with longer operative time but offers advantages such as smaller incisions and shorter hospital stays with a comparative safety profile to MP for radical nephrectomy.
The present invention provides a medical composition used for treating infection by treponema pallidum, tinea unguium, dermatophytosis, and multiplicity of infection of fungi and bacteria, and application thereof. The composition is prepared from antimycotic ingredients and anti-bacterium ingredients in a synergy mode. The composition especially contains bifonazole and chlorhexidine. The medical composition provided by the present invention can be used as medicine for external use. Compared with the scope of treatment of common antimicrobial for external use, the scope of treatment is wide. The medical composition is clinically applied to treat infectious diseases, such as shallow fungi of the skin, bacterial infection, infection by treponema pallidum, tinea unguium, dermatophytosis, etc. The medical composition has the characteristics of high therapeutic effect, low relapse rate, low toxicity, etc.
On patients of this group were performed the palatal pedicle subepithelial connective tissue flap after the extraction, following the technique described by Khoury \& Happe (2000), which consists of total detachment of the palatal flap followed by division of the flap to release the connective tissue, maintain a pedicle and sliding it to cover the fresh socket by primary intention. The sutures were removed seven to ten days of postoperative.
In an 8-week study of 63 postmenopausal women, a dose of raloxifene hydrochloride (HCl) 600 mg/day was safely tolerated. In clinical trials, no raloxifene overdose has been reported. 

In postmarketing spontaneous reports, raloxifene overdose has been reported very rarely (less than 1 out of 10,000 [<0.01%] patients treated). The highest overdose has been approximately 1.5 grams. No fatalities associated with raloxifene overdose have been reported. Adverse reactions were reported in approximately half of the adults who took ≥180 mg raloxifene HCl and included leg cramps and dizziness. 

Two 18-month-old children each ingested raloxifene HCl 180 mg. In these two children, symptoms reported included ataxia, dizziness, vomiting, rash, diarrhea, tremor, and flushing, as well as elevation in alkaline phosphatase. 

There is no specific antidote for raloxifene. 

No mortality was seen after a single oral dose in rats or mice at 5000 mg/kg (810 times the human dose for rats and 405 times the human dose for mice based on surface area, mg/m2) or in monkeys at 1000 mg/kg (80 times the AUC in humans).
BACKGROUND: Both genetic and epigenetic variations of GLP1R influence the development and progression of obesity. However, the underlying mechanism remains elusive. This study aims to explore the mediation roles of obesity-related methylation sites in GLP1R gene variants-obesity association.
METHODS: A total of 300 Chinese adult participants were included in this study and classified into two groups: 180 metabolically healthy obesity (MHO) cases and 120 metabolically healthy normal-weight (MHNW) controls. Questionnaire investigation, physical measurement and laboratory examination were assessed in all participants. 18 single nucleotide polymorphisms (SNPs) and 31 CpG sites were selected for genotype and methylation assays. Causal inference test (CIT) was performed to evaluate the associations between GLP1R genetic variation, DNA methylation and MHO.
RESULTS: The study found that rs4714211 polymorphism of GLP1R gene was significantly associated with MHO. Additionally, methylation sites in the intronic region of GLP1R (GLP1R-68-CpG 7.8.9; GLP1R-68-CpG 12.13; GLP1R-68-CpG 17; GLP1R-68-CpG 21) were associated with MHO, and two of these methylation sites (GLP1R-68-CpG 7.8.9; GLP1R-68-CpG 17) partially mediated the association between genotypes and MHO.
CONCLUSIONS: Not only the gene polymorphism, but also the DNA methylation of GLP1R was associated with MHO. Epigenetic changes in the methylome may in part explain the relationship between genetic variants and MHO.