anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Intentionality is defined as the property of being about or directed toward a subject, as inherent in conscious states, beliefs, or creations of the mind. In nursing science, intentionality has been conceptualized as a dynamic and evolutionary antecedent of transpersonal caring in the mutual healing process. Person experience stress, trauma, loss, and crisis in their lives in a caring relationship. These situations precipitate a need for healing. Intentionality enhances presence and brings a more profound strength and focus to each interaction. Authentic presence allows the nurse to hear the call. A nurse's goal and purposeful thought activate intentionality. The intentionality focuses on caring-healing consciousness. The nurse and person enter the caring moment. The nurse and the person enter a shared consciousness field.

Intentionality is an ongoing process of discovering the nurse's self, purpose, and mission in life. The nurse's intentionality is a dynamic concept that evolves continuously. The nurse's cultural and ethnic background, philosophical and religious beliefs, life experiences, capacity for reflection, and self-awareness influence intentionality development and expression. It is recommended that nurses be encouraged to foster self-care and seek mentors and those who will support intentional care and healing practices. Also, breathing techniques, meditation, mindfulness, and self-reflection are recommended exercises for developing intentionality. Mindfulness is one way to cultivate personal knowing, awareness, and intentionality to facilitate growth and development in a transpersonal caring relationship. Mindfulness is consistently paying attention to what is happening in the present moment. Mindfulness helps support full attention, deep understanding, and immediacy in caring practice. Practicing mindfulness, the nurse becomes fully available to see, understand, love, and care. Mindfulness facilitates attending to one's thoughts and actions in each moment to extend compassion to self, others, the world, and beyond.

Evidence shows that mindfulness-based interventions (MBI) help to reduce work-related stress, psychological distress, depression, burnout, and compassion fatigue. Also, MBI positively affects self-care awareness, emotion management, empathy satisfaction, professionals' receptivity, motivation, and responsiveness to others. However, no research has been found to increase the nurse's mindful awareness or improve intentionality in the caring relationship. The study aimed to explore nurses' perceptions of intentionality in caring relationships and the effectiveness of the mindful caring education program based on the Theory of Unitary Caring Science. In this context, the research questions are as follows:

Research Question 1. What are nurses' perceptions of intentionality in the caring relationship? Research Question 2. What are the facilitators of intentionality in the caring relationship? Research Question 3. What are the impediments to intentionality in the caring relationship? Research Question 4. Is a mindful caring education program effective in improving nurses' intentionality?
Safety and effectiveness in pediatric patients below the age of 12 years have not been established. Controlled clinical studies have shown that intranasal corticosteroids may cause a reduction in growth velocity in pediatric patients. This effect has been observed in the absence of laboratory evidence of hypothalamic-pituitary-adrenal (HPA) axis suppression, suggesting that growth velocity is a more sensitive indicator of systemic corticosteroid exposure in pediatric patients than some commonly used tests of HPA axis function. The long-term effects of this reduction in growth velocity associated with intranasal corticosteroids, including the impact on final adult height, are unknown. The potential for "catch up" growth following discontinuation of treatment with intranasal corticosteroids has not been adequately studied. The growth of pediatric patients receiving intranasal corticosteroids, including AllerNaze, should be monitored routinely (e.g. via stadiometry). The potential growth effects of prolonged treatment should be weighed against clinical benefits obtained and the availability of safe and effective noncorticosteroid treatment alternatives. To minimize the systemic effects of intranasal corticosteroids, including AllerNaze, each patient should be titrated to the lowest dose that effectively controls his/her symptoms.
Tectal gliomas represent a subset of low-grade tumors that arise in the tectal region at the roof of the brainstem. Symptoms of tectal glioma include those caused by increased intracranial pressure due to obstructive hydrocephalus. Headache, blurred vision, double vision, nausea and vomiting are common symptoms. In the treatment, ETV (endoscopic third ventriculostomy) or VP-shunt (ventriculoperitoneal) can be applied to treat hydrocephalus. Tectal gliomas are usually diagnosed in childhood and often occur in adults. They are often benign, slowly progressing lesions; outpatient clinical and radiological follow- up is sufficient. We present two cases of pediatric patients with mesencephalic tectal plate tumors. An 11-year-old boy and a 15-year-old girl applied to the Emergency Department with different complaints. The 11 year-old-boy was treated with VP-shunt due to acute hydrocephalus.
Capsule containing 3,000 IU of cholecalciferol will be given at the end of each hemodialysis session. Dissolved with olive oil and coated by soft capsule made of gelatin and glycerin.
The gut-lung axis is a postulated bi-directional connection between the gut and lung microbiomes where changes at one site can induce changes in another. Although pre-clinical evidence exists, the clinical evidence, particularly in paediatric patients is currently lacking. Changes in the gut microbiome in young children have been noted prior to asthma development although concomitant investigations into the gut and lungs have not yet been made in children with asthma. Furthermore, a causal relationship between IBD and respiratory disease has recently been noted. Associations have also been made between early-life environmental factors such as the protective effects of breastfeeding on respiratory health which hints at connections between dietary intake and respiratory health, possibly via the gut-lung axis. The investigators aim to investigate the gut-lung axis in children via a multi-omics approach.

Part A (cross-sectional): The investigators aim to investigate correlations between the gut and lung microbiome in 3 cohorts of children aged 0-16 attending the Royal Hospital for Children in Glasgow: Respiratory patients, GI patients and Orthopaedic patients. Although this is a hypothesis-generating study, the investigators would like to validate this bi-directional link between the gut and the lung microbiomes. The investigators hypothesise that children with respiratory disease should have a disturbed gut microbiome and children with GI disease should present with a disturbed respiratory microbiome (assessed ecologically and functionally via metabolic and molecular biology analyses). Children receiving orthopaedic procedures without active signs of respiratory or GI issues will serve as the benchmark of a healthy 'gut-lung axis'. The investigators will also aim to investigate potential mechanisms of communication between the gut and lungs in blood via immunological, metabolic, and molecular analyses. Dietary analysis, relevant clinical data and a health questionnaire will be completed by children. Additionally, a 3-day estimated weighed food diary will be completed by the participants and a validated Food Frequency Questionnaire (FFQ) in children aged 3 and above will be used to correlate dietary intake to biological date obtained relating to the gut-lung axis.

Part B (longitudinal): Investigating the Gut-Lung axis in asthma pre and post biologics therapy. The investigators aim to investigate connections between the airway and gut-microbiome, blood and responsiveness to patients receiving biologics therapy (as part of their standard of care). Two cohorts of children will be recruited: children with asthma/wheeze not indicated for biologics and children with asthma/wheeze indicated for biologics. The investigators aim to assess whether biologics modulate the gut-lung axis by sampling airways, stool and blood from children at two time points (before and after starting therapy, compared to the no therapy group). Nutritional data and relevant clinical data will be collected.
AIMS: We adopted a modeling approach to predict the likely future prevalence of type 2 diabetes, taking into account demographic changes and trends in obesity and smoking in Brazil. We then used the model to estimate the likely future impact of different policy scenarios, such as policies to reduce obesity.
METHODS: The IMPACT TYPE 2 DIABETES model uses a Markov approach to integrate population, obesity, and smoking trends to estimate future type 2 diabetes prevalence. We developed a model for the Brazilian population from 2006 to 2036. Data on the Brazilian population in relation to sex and age were collected from the Brazilian Institute of Geography and Statistics, and data on the prevalence of type 2 diabetes, obesity, and smoking were collected from the Surveillance of Risk and Protection Factors for Chronic Diseases by Telephone Survey (VIGITEL).
RESULTS: The observed prevalence of type 2 diabetes among Brazilians aged over 25 years was 10.8% (5.2-14.3%) in 2006, increasing to 13.7% (6.9-18.4%) in 2020. Between 2006 and 2020, the observed prevalence in men increased from 11.0 to 19.1% and women from 10.6 to 21.3%. The model forecasts a dramatic rise in prevalence by 2036 (27.0% overall, 17.1% in men and 35.9% in women). However, if obesity prevalence declines by 1% per year from 2020 to 2036 (Scenario 1), the prevalence of diabetes decreases from 26.3 to 23.7, which represents approximately a 10.0% drop in 16 years. If obesity declined by 5% per year in 16 years as an optimistic target (Scenario 2), the prevalence of diabetes decreased from 26.3 to 21.2, representing a 19.4% drop in diabetes prevalence.
CONCLUSION: The model predicts an increase in the prevalence of type 2 diabetes in Brazil. Even with ambitious targets to reduce obesity prevalence, type 2 diabetes in Brazil will continue to have a large impact on Brazilian public health.
Disclosed is an application of Lactobacillus plantarum ZN-3 in the preparation of drugs for treating or preventing infection of porcine epidemic diarrhea virus. The Lactobacillus plantarum or a fermentation supernatant thereof is capable of reducing infectious activity of the PEDV virus on host cells to a certain extent and inhibiting cell infection caused by invasion of the PEDV virus. All three of the processing techniques for a suspension of Lactobacillus plantarum ZN-3 have direct inhibitory effects on the virus. The fermentation supernatant of Lactobacillus plantarum prepared by adding the fermentation supernatant followed by a PEDV diluent; or by the simultaneous addition of the fermentation supernatant and the PEDV diluent also has direct inhibitory effects on the virus. The inhibition rate of both techniques was 32.08% and 13.21% respectively. The Lactobacillus plantarum or the fermentation supernatant with a pH of 7.0 is not toxic and causes no side effects to cells, and can be used for preventing and treating infection of porcine epidemic diarrhea virus.
The impetus for the current study is to contribute to the development of effective treatments targeted for men and women with either alcohol misuse (e.g., hazardous or binge drinking) or alcohol use disorders (e.g. alcohol abuse or alcohol dependence) and comorbid PTSD. Research findings have shown that these individuals have poorer treatment outcomes and show more severe symptoms than treatment seeking alcohol-misusing or alcohol dependent participants without PTSD. The aim of this study is to replicate and expand on 1) pilot studies demonstrating the effectiveness of a manualized cognitive-behavioral treatment specifically designed for individuals with comorbid substance use disorders and PTSD, "Seeking Safety" 2) preliminary results on the effectiveness of the antidepressant sertraline ("Zoloft") for a dually diagnosed population and 3) the examination of the effectiveness of these interventions over either treatment alone. We are comparing "Seeking Safety" alone to "Seeking Safety" in combination with the antidepressant medication sertraline ("Zoloft") in terms of their effectiveness in reducing alcohol use and PTSD symptoms. Participants will be randomly assigned to one of two treatments (Seeking Safety + Med or Seeking Safety + placebo) and will be evaluated at baseline, at completion of the treatment (12 sessions over 12 weeks), and again at 6 months and 12 months post-treatment. Secondary aims of the study include exploring potential differences between alcoholic subtypes on treatment outcomes; impact of combined treatment on treatment participation and global psychiatric symptoms; differences in the time course and order of changes in alcohol and drug use and PTSD symptoms by condition.
The invention relates to a preparation method of a radix puerariae peptide, and applications thereof. The radix puerariae powder is a matter of macromolecule, which is not easy to be absorbed by a human body. A papain and a bromelin are used for carrying out degradation to radix puerariae concentrated powder so as to obtain the radix puerariae peptide, wherein, the active ingredients such as isoflavone and puerarin are extremely easy to be absorbed by the human body. The radix puerariae peptide has better curing effects to hypertension, hyperlipemia, hyperglycemia, obesity and cardiovascular and cerebrovascular diseases. The intermediate product of radix puerariae peptide materials can be used for preparing drugs, health care products, food (beverages), and additive and synergist thereof. The method has the advantages of low investment, quick effect, high added value, simultaneously, saving energy, reducing exhaust, reducing consumption, protecting environment and being suitable for industrial production.
This is a single-center, prospective diagnostic-accuracy study. All women who will undergo surgery for DE after preoperative ultrasound for six consecutive months will be included. Anamnestic and preoperative (physical objective and ultrasonographic) data of these patients will be collected. Surgical and pathological data will be analyzed to confirm the presence of parametrial DE.

All the study procedures are done according to our clinical practice. Demographic and ultrasonographic data will be collected from the preoperative evaluation, which is routinely done at our institution by four ultrasonographic expert in diagnosing deep endometriosis. Surgical and pathological data will be collected during surgical procedures and hospital stay.
The invention relates to adjusting a psychometric test, and to carrying out psychometric testing, as well as the corresponding data structures, computer program products, devices and systems. Input from a plurality of users is received, for example by means of a questionnaire. The input is indicative of a first psychometric variable and a second psychometric variable, where the first and the second psychometric variables being essentially independent from each other. The input allows classifying users into at least four classes using at least a first classification threshold for the first psychometric variable and at least a second classification threshold for the second psychometric variable. The classification thresholds for the classes (and possible sub-classes) are adjustable so that the classification of users into said classes is altered so that at least one user is re-classified to a different class. The questions in the input questionnaire may also be changed, and they may e.g. be translated to another language. Furthermore, the system generates textual output based on the classification, and the users may be allowed to vote on the output descriptions. This way, descriptions that are not appreciated by the users may be pushed down in the presentation priority. The above adjustments may take place by comparison to another population and/or test, by targeted adjustment of the classification to reach a desired class and sub-class distribution, and/or based on user feedback (e.g. voting).
To date there are only pirfenidone (PFD) and nintedanib to be given conditional recommendation in idiopathic pulmonary fibrosis (IPF) therapies with slowing disease progression, but neither has prospectively shown a reduced mortality. It is one of the urgent topics to find effective drugs for pulmonary fibrosis in medicine. Previous studies have demonstrated that microcystin-RR (MC-RR) effectively alleviates bleomycin-induced pulmonary fibrosis, but the mechanism has not been fully elucidated yet. We further conducted a comparison of therapeutic effect on the model animals of pulmonary fibrosis between MC-RR and PFD with histopathology and the expression of the molecular markers involved in differentiation, proliferation and metabolism of myofibroblasts, a major effector cell of tissue fibrosis. The levels of the enzyme molecules for maintaining the stability of interstitial structure were also evaluated. Our results showed that MC-RR and PFD effectively alleviated pulmonary fibrosis in model mice with a decreased signaling and marker molecules associated with myofibroblast differentiation and lung fibrotic lesion. In the meantime, both MC-RR and PFD treatment are beneficial to restore molecular dynamics of interstitial tissue and maintain the stability of interstitial architecture. Unexpectedly, MC-RR, rather than PFD, showed a significant effect on inhibiting PKM2-HIF-1α signaling and reducing the level of p-STAT3. Additionally, MC-RR showed a better inhibition effect on FGFR1 expression. Given that PKM2-HIF-1α and activated STAT3 molecular present a critical role in promoting the proliferation of myofibroblasts, MC-RR as a new strategy for IPF treatment has potential advantage over PFD.
A process for the production of a substance to eliminate the bacteria  Helicobacter Pylori , involving boiling 3 (three) kilos of Cuachalalate ( Amphipterygium adstringens ) crust in sixteen (16) liters of water in a close express pan with a capacity of 21 (twenty-one) liters, for a period of 5 (five) hours, without permitting evaporation. After the boiling period has elapsed, using a filter system, the crust is separated from the resulting liquid or solution. After separating the crust, around six (6) liters of the new solution are obtained. Since the taste of the solution is strong, 1 (one) cubic centimeter of liquid menthol is added in order to make the solution more drinkable. After the prior steps have been taken, the solution must be refrigerated until it is bottled and used. Pills and tablets can be manufactured from the original solution.
Glucagon should be administered cautiously to patients with a history suggestive of insulinoma, pheochromocytoma, or both. In patients with insulinoma, intravenous administration of glucagon may produce an initial increase in blood glucose; however, because of glucagon’s hyperglycemic effect the insulinoma may release insulin and cause subsequent hypoglycemia. A patient developing symptoms of hypoglycemia after a dose of glucagon should be given glucose orally, intravenously, or by gavage, whichever is most appropriate.

Exogenous glucagon also stimulates the release of catecholamines. In the presence of pheochromocytoma, glucagon can cause the tumor to release catecholamines, which may result in a sudden and marked increase in blood pressure. If a patient develops a sudden increase in blood pressure, 5 to 10 mg of phentolamine mesylate may be administered intravenously in an attempt to control the blood pressure.  
Generalized allergic reactions, including urticaria, respiratory distress, and hypotension, have been reported in patients who received glucagon by injection.

  
Necrolytic migratory erythema (NME), a skin rash commonly associated with glucagonomas (glucagon-producing tumors) and characterized by scaly, pruritic erythematous plaques, bullae, and erosions, has been reported postmarketing following continuous glucagon infusion. NME lesions may affect the face, groin, perineum and legs or be more widespread. In the reported cases NME resolved with discontinuation of the glucagon, and treatment with corticosteroids was not effective. Should NME occur, consider whether the benefits of continuous glucagon infusion outweigh the risks.
No incentive. Usual care (plus EMD with reminders) for 12-weeks.
All subject of the study have a knee osteoarthritis (OA) and are going to have a total arthroplasty. Diagnostic performance of ultrasonography is evaluated on ex vivo cartilage samples (2 samples per patient are selected with different stage of OA : 1 with early stage and 1 with advanced stage).
OBJECTIVES: Olanzapine has been shown to be effective in preventing chemotherapy-induced nausea and vomiting (CINV) after highly emetogenic chemotherapy (HEC); however, there is limited work on the impact of CINV on health-related quality of life (HRQoL) and the comparative cost-effectiveness of CINV prophylaxis in the Malaysian context. Therefore, this study was conducted to determine the HRQoL using EQ-5D-5L and the cost-effectiveness of olanzapine compared with aprepitant for CINV prophylaxis in Malaysia using data from a local study.
METHODS: Fifty-nine chemo-naive patients receiving either olanzapine or aprepitant were randomly recruited and completed the EQ-5D-5L before and day 5 after HEC. HRQoL utility scores were analyzed according to the Malaysian valuation set. The economic evaluation was conducted from a healthcare payer perspective with a 5-day time horizon. Quality-adjusted life days (QALD) and the rate of successfully treated patients were used to measure health effects. The incremental cost-effectiveness ratio is assessed as the mean difference between groups' costs per mean difference in health effects. A one-way sensitivity analysis was performed to assess variations that might affect outcomes.
RESULTS: Aprepitant and olanzapine arms' patients had comparable baseline mean HRQoL utility scores of 0.920 (SD = 0.097) and 0.930 (SD = 0.117), respectively; however, on day 5, a significant difference (P value = .006) was observed with mean score of 0.778 (SD = 0.168) for aprepitant and 0.889 (SD = 0.133) for olanzapine. The cost per successfully treated patient in the aprepitant arm was 60 times greater than in the olanzapine arm (Malaysian Ringgit [MYR] 927 vs MYR 14.83). Likewise, the cost per QALD gain in the aprepitant arm was 36 times higher than in the olanzapine arm (MYR 57.05 vs MYR 1.57). Incremental cost-effectiveness ratio of MYR -937.00 (USD -200.98) per successfully treated patient and MYR -391.84 (USD -85.43) per QALD gained for olanzapine compared with the aprepitant-based regimen.
CONCLUSIONS: An olanzapine-based regimen is a cost-effective therapeutic substitution in patients receiving HEC in Malaysia.