anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A healthcare monitoring and alarm system 100 configured to detect the presence and status of a tag 102 via a hub 104. The tag is configured to communicate with the hub either directly or via a relay 108. The hub has an interface configured to communicate with a remote help centre, a transceiver configured to communicate with the tag and a connection having a transceiver configured to communicate with a relay. The tag has a transceiver configured to communicate to the hub the presence of the tag and the status of the tag, including the barometric status, orientation of the tag and energy readings or acceleration associated with movement of the tag. The transceiver in the tag is further configured to receive an interrogation signal from a locator device and the tag is configured to send a response transmission to enable the tag to be located. A processer in the tag encodes a data packet consisting of the status to the hub via the transceiver. The hub is configured to generate an alarm condition when the tag is not detected, the tag moves to an unauthorised area or the monitored status indicates that a person in possession of the tag needs attention.
PURPOSE:The titled contrast medium consisting of a fluorocarbon emulsion with little toxicity without in vivo accumulation property. CONSTITUTION:A contrast medium for ultrasonic diagnosis consisting of a fluorocarbon emulsion, prepared by incorporating a 6-12C fluorocarbon (FC) with at least one emulsifying agent selected from phospholipids, e.g. egg yolk phospholipid, hydrogenated phospholipids and high polymer nonionic surfactants having 2,000-20,000 molecular weight, e.g. polyoxyethylene, and further a phospholipid as an emulsification assistant for the above-mentioned surfactant as the emulsifying agent, and having 0.05-0.4mu particle diameter. More preferably, a fluorocarbon emulsion containing at least one selected from 6-22C fatty acids, e.g. caprylic acid, salt of the above-mentioned fatty acids and monoglycerides of the above-mentioned fatty acids as an emulsification assistant is added thereto. The composition ratios of the respective components are preferably as follows: 5-50w/v% FC, 2-6w/v% emulsifying agent and 0.01-0.1w/v% emulsification assistant.
The maximum illumination button on hte 2RT laser will be briefly pressed by the operating physician at each of the 12 locations where and when the laser would normally be applied. The laser remains in standby mode preventing accidental laser firing.
The proposed 'Joyful Sleep' program will be conducted weekly, 2 hours per session, 8 sessions, group-based in mindfulness. The content and skills are based upon MBSR, MAPs and Tai Chi. The proposed topics include: 1) mindfulness and insomnia, 2) mindful awareness of stress, 3) mindful working with thoughts, 4) mindful working with emotions, 5) mindful interactions, 6) moving mindfulness meditation: the first taste of Tai Chi, 7) moving mindfulness meditation: the second taste of Tai Chi, 8) dealing with obstacles of mindful practices and wrap-up. Mindfulness practices embedded in the program will include mindfulness breathing meditation, body scan meditation, sitting meditation, standing meditation, walking meditation, Taichi, and daily life meditation.
OBJECTIVE: This study aimed (1) to simulate pedicle screw pullout after intraoperative external wall perforation and (2) to assess restoration strength with different thread designs in the pedicle screw instrumentation for osteoporotic thoracic vertebrae.
METHODS: Twenty fresh-frozen human cadaveric thoracic vertebra bodies were prepared and divided into 4 groups: group 1, 5.5 mm × 45 mm polyaxial single thread pedicle screws (PASTS); group 2, after wall injury 5.5 mm × 45 mm PASTS; group 3, 6.5 mm × 45 mm PASTS after wall injury; and group 4: 6.5 mm × 45 mm polyaxial mixed-threaded screws after wall injury. While group 1 was the control group, groups 2, 3, and 4 were used as study groups after the lateral wall breach. All prepared screw units were placed on a universal pullout measurement testing device.
RESULTS: The mean bone mineral density for 20 thoracic vertebrae was 0.57 ± 0.12 g/cm2 (range 0.53-0.6 g/cm2 ). The mean pullout strength was 474.90 Newtons (N) for group 1, 412.85 N for group 2, 475.4 N for group 3, and 630.74N for group 4. The lateral wall breach caused a 14.1 % decrease in average pullout strength compared with the initial screw pullout. Mixed (double)-threaded screws increased pullout strength compared to 6.5 mm screws (P=.036) Conclusion: Using a 1 mm thicker polyaxial pedicle screw or mixed (double)-threaded pedicle screw seems to increase pullout strength; however, this was statistically significant only for group 4. In the thoracic spine, the redirection possibility of the pedicle screw is limited, and augmentation with cement will not be appropriate due to the risk of wall injury-related leakage. Therefore, care should be taken to avoid violating the lateral cortex by using appropriate pedicle entry points and trajectories.
Ischemia is treated to prevent or manage disease by delivering stem cells derived from cord blood and/or tissue. A patient suffering from disease caused in at least some part by ischemia is selected. At least one dose consisting of an effective amount of stem cells is administrated through intravenous (IV), intra thecal, intra-arterial, via catheter into the organ, via Myostar catheter into the heart, intracoronary, intrapericardial, and/or by direct injection into the organ. Effectiveness of the administration is monitored at selected time periods to determine whether there exists an improved clinical indication. A second dose is administered by a method that is at least invasive as that utilized in the prior dose, and the steps are repeated until the clinical indication shows improvement or until there is contraindication to continued treatment. Diseases include at least one of Ischemia, arteriosclerosis, complications of ischemia, decreased perfusion, aging or diabetes.
FIELD: medicine. ^ SUBSTANCE: group of inventions relates to medicine, methods and systems of magnetic-resonance (MR) measurement of ultrashort T2*-relaxation «, which uses obtaining spin-echo, for control of quantity, migration, proliferation and/or homing of cells, marked with great amount of iron, in cell transport, cell therapy, including in vivo. Sequence of MR images is generated and T2*-R is measured with decay curve T2*, obtained by series of spin-echo images, including the following stages: induction of first spin-echo signal (SES), generating first spin-echo image, and set of SES, generating series of additional spin-echo images from suitable displacements of decay T2*; obtaining T2* image by fitting of exponent. First SIS and second SIS are formed by means of first radio-frequency pulse (RFP), followed by second RFP, different from first. SIS is induced by RFP with small angle of inclination. Echo is formed by application of gradient reading. In tissues, which contain cells, marked by iron with high concentration, with T2 lower than 1 msec signal can decay to the level of noise with echo time 2 msec. ^ EFFECT: as T2 is much longer in cells, marked with superparamagnetic iron oxide, and signal, obtained by means of spin-echo, is much stronger than signal, obtained by means of gradient echo, claimed method and system for its realisation make it possible to avoid negative effects, associated with significant loss of signal on image, using relatively long T2 decay in obtaining a series of spin-echo images, facilitating determination of T2*, in spite of considerable weakening of signal, associated with decay of ultrashort T2*, thus ensure improvement of quantitative evaluation of marked cells; make it possible to measure ultrashort T2* of other contrasting agents, causing considerable difference between T2 and T2*-P. ^ 12 cl, 2 ex, 7 dwg
Cancer incidence is increasingly seen in younger individuals. Molecular distinctions between young and elderly patients at onset are understudied. This study used public databases to explore genomic, transcriptomic, and immune-related features across age groups in cervical cancer. Additionally, it aims to create a prognostic model applicable across diverse age cohorts, enabling precise patient stratification, and personalized therapies. Gene mutations, expression data, and clinicopathological information were obtained from 317 cervical cancer patients. These patients were divided into a young group and an old group based on the median age of onset. The characteristics of differential gene mutation, gene expression, and immune cells analysis were analyzed by R software. Finally, the prognostic model was constructed by univariate Cox, least absolute shrinkage and selection operator, and multivariate Cox regression analyses of angiogenic and immune gene sets. Its validity was further confirmed using an additional 300 cervical squamous cell carcinoma and endocervical adenocarcinoma tissues. Cervical cancer patients at elderly onset age exhibit a significantly higher frequency of NOTCH1 and TP53 driver mutations compared to young patients, along with a notably higher tumor mutational burden. However, there were no significant differences between the 2 groups in terms of genomic instability and age-related mutational signatures. Differential gene expression analysis revealed that the young group significantly upregulated interferon-alpha and gamma responses and exhibited significantly higher activity in multiple metabolic pathways. Immune microenvironment analysis indicated enrichment of dendritic cells and natural killer cells in the young group, while transforming growth factor-β signature was enriched in the elderly group, indicating a higher degree of immune exclusion. A multigene prognostic model based on angiogenesis and T cell immune gene sets showed excellent prognostic performance independent of clinical factors such as age. High-risk groups identified by the model exhibit significant activation of tumor-promoting processes, such as metastasis and angiogenesis. Our study reveals distinct patterns in cancer-driving mechanisms, biological processes, and immune system status between young and elderly patients at onset with cervical cancer. These findings shed light on the age-specific underlying mechanisms of carcinogenesis. Furthermore, an independent molecular prognostic model is constructed to provide valuable references for patient stratification and the development of potential drug targets.
Belonging to the technical field of traditional Chinese medicine preparation, the invention relates to an oral liquid treating psoriasis and its preparation method. The oral liquid is mainly prepared from the following components by weight: 100-300g of natural indigo, 100-300g of lithospermum, and 200-300g of licorice. For the adopted three traditional Chinese medicines, the natural indigo can clear away heat and toxic materials, dispel wind and eliminate dampness; the lithospermum can remove pathogenic heat from blood, and promote blood circulation to remove blood stasis; and the licorice has the efficacy of nourishing blood and moisturizing skin, tonifying qi and strengthening the spleen. Directed at the etiological factors of disharmony between spleen and stomach, stagnation and congestion of qi and blood, blood heat and blood stasis causing psoriasis, the three herbal medicines can achieve the synergistic efficacy of removing pathogenic heat from blood, promoting blood circulation to remove blood stasis, nourishing blood and moisturizing skin. In the invention, the three herbal medicines are processed into an oral liquid, the medicines are small in variety and easy to collect, the treatment method is simple and painless, and no toxic or side effect exists. Thus, the oral liquid is easily accepted by mass patients.
The gut microbiota is an integral part of the human metaorganism that is required to shape physiologic host immune responses including host defense against pathogens. Disease-associated gut dysbiosis has been characterized by blooms of pathobionts, which are bacterial species that can drive disease under certain conditions. Pathobionts like Enterobacteriaceae often bloom during flares of inflammatory bowel disease (IBD) and are causally linked with IBD in murine models. In this issue of the JCI, Hecht and colleagues investigated how simple carbohydrates are causally linked to the bloom of the gut pathobiont Klebsiella pneumoniae, which belong to the Enterobacteriaceae family. Notably, the presence of fiber reduced the dissemination of K. pneumoniae into the blood and liver in a colitis model. Their findings provide a diet-related mechanism for gut dysbiosis, which has implications in the management of IBD and other conditions in which gut dysbiosis is an underlying factor.
Subjects will receive 4 mg of oral rosiglitazone once daily for 3 days during treatment period 1. In treatment period 2, subjects will receive 4 mg oral rosiglitazone once daily on days 1, 2 and 3 along with 150 mg oral casopitant once daily on day 1 and 50 mg oral casopitant once daily on days 2 and 3. The treatment periods will be separated by will be separated by a 5 - 14 day wash-out period.
Gastric cancer presents a significant global health burden, as it is the fifth most common malignancy and fourth leading cause of cancer mortality worldwide. Variations in incidence rates across regions underscores the multifactorial etiology of this disease. The overall 5-year survival rate remains low despite advances in its diagnosis and treatment. Although surgical gastrectomy was previously standard-of-care, endoscopic resection techniques, including endoscopic mucosal resection and endoscopic submucosal dissection (ESD) have emerged as effective alternatives for early lesions. Compared to surgical resection, endoscopic resection techniques have comparable 5-year survival rates, reduced treatment-related adverse events, shorter hospital stays and lower costs. ESD also enables en bloc resection, thus affording organ-sparing curative endoscopic resection for early cancers. In this editorial, we comment on the recent publication by Geng et al regarding gastric cystica profunda (GCP). GCP is a rare gastric pseudotumour with the potential for malignant progression. GCP presents a diagnostic challenge due to its nonspecific clinical manifestations and varied endoscopic appearance. There are several gaps in the literature regarding the diagnosis and management of GCP which warrants further research to standardize patient management. Advances in endoscopic resection techniques offer promising avenues for GCP and early gastric cancers.
Nucleic acid molecules, such as shRNA clusters and artificial miRNA clusters, are disclosed. Also disclosed are methods of use, compositions, cells, viral particles, and kits relating to the nucleic acid molecules disclosed herein. The present disclosure provides, at least in part, nucleic acid molecules such as shRNA clusters encoding shRNA-like molecules and artificial miRNA clusters encoding modified pri-miRNA-like molecules. The shRNA clusters and artificial miRNA clusters disclosed herein can be used, for example, to produce artificial RNA molecules, e.g., RNAi molecules. Cells, viral particles, compositions (e.g., pharmaceutical compositions), kits, and methods related to the nucleic acid molecules (e.g., shRNA clusters and artificial miRNA clusters) are also disclosed. The nucleic acid molecules (e.g., shRNA clusters and artificial miRNA clusters), artificial RNA molecules (e.g., RNAi molecules), cells, viral particles, compositions (e.g., pharmaceutical compositions), kits, and methods disclosed herein can be used to treat or prevent diseases, such as HIV infection and/or AIDS.
Patients will receive intravenous clofarabine once daily for three consecutive days. Doses of clofarabine will start at 4 mg/m2/day and will be escalated to higher dose levels.
Myocardial fibroblasts transform into myofibroblasts during the progression of cardiac fibrosis, together with excessive cardiac fibroblast proliferation. Hence, the prevention and treatment of cardiac fibrosis are significant factors for inhibiting the development of heart failure. P-element Induced WImpy testis-interacting RNAs (PiRNA) are widely expressed in the heart, but their involvement in cardiac fibrosis has not yet been confirmed. We identified differentially expressed PiRNAs using Arraystar PiRNA expression profiling in Angiotensin II models of cardiac fibrosis in vivo and in vitro. We then explored cardiac-fibrosis-associated PiRNA-related proteins, RNA-protein interactomes, immunoprecipitation, and pulldown. We detected fibrosis markers and pathway-related proteins using immunofluorescence, qRT-PCR, and Western blot. We uncovered cardiac fibrosis associated PiRNA (CFAPIR) that was obviously dysregulated during cardiac fibrosis, whereas its overexpression reversed fibrosis in vivo and in vitro. Mechanistically, CFAPIR competitively bound muscleblind like protein 2 (MBNL2) and the cyclin-dependent kinase inhibitor P21 to regulate the TGF-β1/SMAD3 signaling pathway.
To investigate the effect of extracorporeal shock wave on the treatment of talus bone marrow edema by regulating subchondral bone homeostasis through tumor necrosis factor-α (TNF-α)/hypoxia-inducible factor-1α (HIF-1α)/vascular endothelial growth factor (VEGF) signaling pathway. A total of 81 patients with talus bone marrow edema admitted to our hospital from May 2019 to May 2021 were studied and divided into control group (n = 40) and extracorporeal shock group (n = 41) according to random number table method. The control group was given conventional treatment, and the extracorporeal shock group was combined with extracorporeal shock wave therapy on the basis of the control group. The expression of TNF-α, HIF-1α, and VEGF in the 2 groups were compared, pain degree, and the area of talus bone marrow edema was evaluated by magnetic resonance imaging. The visual analogue scale scores of 1 month, 2 months and 5 months after treatment were decreased in both groups, and the extracorporeal shock group was lower than the control group (P < .05). After 5 months of treatment, the expressions of TNF-α and HIF-1α were decreased in both groups, and the extracorporeal shock group was lower than the control group, VEGF was increased, and the extracorporeal shock group was higher than the control group (P < .05), and the western blot expression levels of TNF-α, HIF-1α and VEGF in the extracorporeal shock group were higher than the control group (P < .05). The dorsiflexion motion and plantar flexion motion of both groups were increased, and the extracorporeal shock group was higher than the control group (P < .05). Extracorporeal shock wave therapy can regulate subchondral bone homeostasis through TNF-α/HIF-1α/VEGF signaling pathway to treat talus bone marrow edema, reduce the pain degree of talus bone marrow edema, and improve ankle joint function.
This is a Single-Arm study with Single- and Multiple- Dose Periods. Study participants will receive a single dose of brivaracetam (BRV) on Day 1 and will then receive multiple doses of brivaracetam from Day 5-10.
Aflibercept is given monthly (at least 3 times) until resolution of macular edema after which the patient is observed monthly. If there is recurrence of macula edema, the patient is given aflibercept according to a treat-and-extend regimen.
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine, namely, to anaesthesiology and dentistry, and can be used as an anaesthesia care of dental interventions. That is ensured by infiltration anaesthesia as follows. In the middle of each gingival papilla adjoining a tooth to be anaesthetised, a short-needle syringe is pricked in from a vestibular side at an angle 90 degrees to a surface of a mucous membrane of the medial and distal gingival papilla. The needle is moved forward firmly to a bone. Then an anaesthetic drug 0.2 ml of 4 % articaine and adrenaline of various concentrations is introduced from each side. ^ EFFECT: method provides the adequate and prolonged anaesthesia ensured by the most exact delivery of the anaesthetic drug and vasoconstrictive agent to nerve fibres. ^ 1 ex
This study is a randomized clinical trial within a Substance Use Disorder (SUD) specialty clinic to evaluate whether treatment as usual (TAU) plus Written Exposure Therapy (WET) is superior to TAU augmented by a neutral topic writing condition on both PTSD and addiction outcomes for Veterans in SUD treatment. Veterans with a current diagnosis of SUD and comorbid PTSD will be randomized to either WET plus TAU or TAU augmented by a neutral topic writing condition. During the first writing session, participants will be asked to write about either a personal traumatic experience (WET) or a neutral topic (control). In sessions 2 through 5, participants will again meet with the study therapist for 45 minutes (maintaining the same writing condition as assigned in session one). Measures of trauma symptoms, distress, and mood will be collected at each writing session, with additional assessments at baseline, at post-treatment (following 5 writing sessions), 8-weeks, and 12-weeks post-baseline assessment. The primary aim of this study is to examine whether WET augmentation of TAU improves trauma symptoms for Veterans with SUD and PTSD who are receiving outpatient SUD treatment compared to TAU with a neutral writing control. The secondary aim will examine whether WET improves SUD outcomes for Veterans with comorbid PTSD compared to TAU with a neutral writing control. If results prove promising, they will support WET as an effective brief, cost efficient, easy to disseminate, adjunct to current SUD treatment for Veterans with comorbid PTSD.
At present, the most prevalent pharmaceutical dosage forms, the oral immediate-release tablets and capsules, are porous solids of compacted drug and excipient powders. Upon ingestion, physiological fluid percolates the open pores, and the dosage form disintegrates and the drug dissolves. Because the pores in the compacted solids are not well connected, however, fluid percolation generally is not uniform, and the drug release rate is difficult to predict and control. To overcome such limitations, therefore, herein a structured solid dosage form is disclosed. The structured solid dosage form comprises a structural assembly of one or more repeatably arranged, extruded structural elements. The elements comprise segments separated and spaced from adjoining segments by free spacings defining one or more substantially interconnected free spaces, or channels, in the dosage form through which a physiological fluid may percolate. The disclosed dosage form enables more predictable drug release rates, and can be readily manufactured by 3D-printing.
The application relates to the technical field of epidemic prevention control, and discloses a method for tracing joint sealing personnel, which comprises the following steps: the device ID of the user terminal of the infected person is acquired. And respectively determining the target Bluetooth device, the target place, the target contact time point and the environmental characteristics of the environment where the target blue device is located according to the device ID. And acquiring the survival time of the virus corresponding to the environmental characteristics. And determining the sealing time period according to the virus survival time and the target contact time point. And determining suspected close contact persons according to the close contact time period and the target place. Thus, by utilizing the characteristic that the survival time of the virus is different in places with different environmental characteristics, a more accurate close contact time period can be determined. The tracing range is narrowed, so that suspected close-fitting personnel can be determined more quickly, and the efficiency of tracing the close-fitting personnel is improved. The application also discloses a device and a system for tracing the tight-lock person, electronic equipment and a storage medium.