anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
COMPARE is part of the iTech NIH U19, which has an overall goal to develop innovative technology-focused interventions addressing the HIV prevention and care continuum for youth. In years 1-2 of the iTech grant, the investigators optimized and pilot tested using a similar study design and identical study outcomes, two distinct mobile apps called LYNX and MyChoices. Each app is designed to increase HIV testing and PrEP uptake among YMSM. In this study, the individual apps are being tested in this follow-on research study to evaluate for efficacy. YMSM will be randomized to receive either MyChoices, LYNX, or SOC. LYNX uses the Information-Motivation-Behavior Skills (IMB) model and is a highly interactive mobile app to promote accurate risk perception, increase HIV/STI testing, and linkage to PrEP. MyChoices is guided by the Social Cognitive Theory (SCT) model, is adapted from HealthMindr and developed using iterative feedback from youth refined to maximize acceptability among YMSM. It includes three major functions that are designed to promote self-efficacy, self-regulation, goal-setting and environmental influences to impact behavior change. The SOC includes information on HIV testing and PrEP with the provision of referrals to local HIV/STI testing and PrEP resources.
Patients receive oral nelfinavir mesylate twice daily on days 1-28. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
PURPOSE:A hair dye, containing 5-dihydroxynaphthalene and 2,4-diaminophenol as active ingredients and capable of coloring by oxidation with air and dyeing the hair to a natural hue, having improved dyeability, color fastness to daylight exposure and resistance to washing with ready usage. CONSTITUTION:A hair dye containing 2,4-diaminophenol and 1,5- dihydroxynaphthalene or a salt thereof as active ingredients. The amounts to be blended are preferably within 0.1-5% range respectively in view of hue and dyeability (density of color). If the blending ratio of the 2,4-diaminophenol is increased, the hue becomes brown. If the blending ratio of the 1,5- dihydroxynaphthalene is increased, the hue becomes black. The composition of the hair dye is particularly preferably the form of an aerosol product, etc., having improved preservation stability. Another dye, e.g. nitro dye, disperse dye, acid dye, etc., may be further blended to the combination recipe of the above-mentioned active ingredients for toning.
Subjects in this arm will apply Tapinarof 1% cream topically once daily for a 16-week open-label treatment period. Participants who achieve disease clearance after 16 weeks may discontinue treatment and will be monitored for sustained response up to 52 weeks. Those who do not achieve clearance will continue the treatment during an extension period for up to 36 additional weeks or until clearance is achieved, whichever comes first. Regular follow-up visits will assess the duration of disease clearance and monitor for any potential recurrence of keratoderma.
Patients receive selumetinib PO QD and erlotinib hydrochloride PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
The aim of the study is to investigate the effect of the oral probiotic Lactobacillus salivarius on oral hygiene indices and halitosis in patients wearing orthodontic braces and patients wearing orthodontic aligners. The study is a prospective, randomized, placebo-controlled, double blinded, with four parallel groups and an equal allocation ratio in all groups. Patients 12-18 years old undergoing ﬁxed orthodontic treatment will be randomly allocated to probiotic group A (n=30) and placebo group B (n=30). Patients ≥18 years old wearing aligners (Invisalign™ ) will be randomly allocated to probiotic group C (n=30) and placebo group D (n=30). All participants will consume lozenges for one month. Assessments will be taken at baseline, at the end of the intervention and at a 2 month free-intervention follow-up. The outcome measures will be modified plaque index (PI), modified gingival index (GI) and halitosis-causing volatile sulfur compound (VSC) levels. Results will be announced at the end of the study.
Although electrical muscle stimulation (EMS) of skeletal muscle effectively prevents muscle atrophy, its effect on the breakdown of muscle component proteins is unknown. In this study, we investigated the biological mechanisms by which EMS-induced muscle contraction inhibits disuse muscle atrophy progression. Experimental animals were divided into a control group and three experimental groups: immobilized (Im; immobilization treatment), low-frequency (LF; immobilization treatment and low-frequency muscle contraction exercise), and high-frequency (HF; immobilization treatment and high-frequency muscle contraction exercise). Following the experimental period, bilateral soleus muscles were collected and analyzed. Atrogin-1 and Muscle RING finger 1 (MuRF-1) mRNA expression levels were significantly higher for the experimental groups than for the control group but were significantly lower for the HF group than for the Im group. Peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) mRNA and protein expression levels in the HF group were significantly higher than those in the Im group, with no significant differences compared to the Con group. Both the Forkhead box O (FoxO)/phosphorylated FoxO and protein kinase B (AKT)/phosphorylated AKT ratios were significantly lower for the Im group than for the control group and significantly higher for the HF group than for the Im group. These results, the suppression of atrogin-1 and MuRF-1 expression for the HF group may be due to decreased nuclear expression of FoxO by AKT phosphorylation and suppression of FoxO transcriptional activity by PGC-1alpha. Furthermore, the number of muscle contractions might be important for effective EMS.
1322102 Treatment of iron deficiency in piglets FISONS Ltd 19 April 1971 [13 March 1970] 23575/71 Heading A5B Iron deficiency in piglets is treated prophylactically by administering orally to the piglet within 24 hours of its birth a complex containing iron and a polysaccharide, a disaccharide, a protein or a polypeptide. The polysaccharide may be a dextran, dextrin, polyglucose, polymannose, polymaltose, polysucrose, polygalactose, mannan, galactan, levan, inulin, polyfructose, xylan, araban, an alginate, chrondroitin or pectin; the end groups of the polysaccharide may be modified by hydrogenation, oxidation, alkali, degradation, heptonate formation or glycerol glycoside formation; the disaccharide may be sucrose and the protein may be gelatin. The complexes may be associated with one or more other non-toxic polyhydroxy compound e.g. sucrose, glycol, sorbose, sorbitol, xylose, glucose or galactose; or one or more non-toxic organic acids e.g. citric, tartaric or aspartic acid. The complex may be used in admixture with another compound which is orally tolerated by the piglet such as an inert diluent, a piglet foodstuff such as milk; a physiologically desirable trace element such as copper, cobalt, manganese or a mixture thereof; a vitamin e.g. vitamins A, D, B 1 , B 2 , B 6 , B 12 , E (or other antioxidants) or a mixture thereof; an antibiotic e.g. a broad spectrum antibiotic such as chlortetracycline hydrochloride and oxytetracylines, a nitrofuran; an absorption aid e.g. an amino acid or an immunoglobulin. The complex may be administered in the piglet's feed or drink and the piglet is preferably reared for at least 2 weeks after the treatment. A composition orally acceptable to the newborn piglet comprises an iron dextran and a diluent, surface active agent, carrier, or other matter which is orally acceptable to the piglet and is in the form of a solid or paste such as a wettable powder, tablet, capsule, pill or bolus.
[GB1322102A]
PROBLEM TO BE SOLVED: To provide a method for producing alcohol beverage hardly having adverse effect on human liver. SOLUTION: This method for producing alcoholic beverage comprises multistage process obtaining low-viscosity water used for production of alcoholic beverage hardly having adverse effect on human liver. The process is constituted of plural individual batch type processes and a product having viscosity lower than a product obtained by process in previous stage is obtained in each subsequent process. The first process is carried out by passing electric current through water free from electrolyte and water having low viscosity is obtained thereby. As a result, the discharged water is put into a serial type batch type energy-feeding reactor. In this time, water is continuously irradiated with far- infrared rays for a definite retention time in each reactor. A housing vessel is provided in each batch type reactor and a proper amount of water can be discharged from the reactor.
Participants will receive vamikibart 0.25 milligrams (mg), by intravitreal (IVT) injection, on Day 1 and every 8th week (Q8W), up to Week 44, for a total of 6 injections. A sham procedure will be administered during study visits at which no study drug is administered to maintain masking between treatment arms.
A standard placement of the electrodes will be used for GVS and sham, placed on the mastoids. Weak currents up to maximally 3 mA will be used (tested before in each participant individually, and expected mean current will be around 1.5 mA). Previous studies have used Magnetic Resonance (MR) compatible GVS without reporting any discomfort for the participants, however weak sensations of nausea could be possible and in case that they are disturbing for the participants the experiment will be aborted. Continuous stimulation for up to 30min with intensities of 1-1.5 mA is generally considered as safe and free of any considerable side effects.
Participants will undergo two 12.5 hour clinic visits. Participants will complete a training on how to start the Dexcom G6 sensor at home. Participants will start the G6 sensor the day before each study visit. For one visit, the system will use insulin only for managing blood sugar. For the other study, the system will use both insulin and pramlintide. The order of the visits will be randomly chosen. For 3 days before the insulin and pramlintide visit, participants will dose with pramlintide before each meal. During the visits, participants will wear one or two Omnipods to delivery insulin and insulin/pramlintide and a Dexcom G6 CGM. The CGM system will provide sensor glucose data every 5 minutes. Sensor glucose data will be wirelessly transmitted via Bluetooth Low Energy (BTLE) from the Dexcom G6 to the smartphone master controller every 5 minutes. The smartphone will communicate via BTLE to an Omnipod for insulin delivery. The closed loop system will receive activity data through a Polar M600 watch worn by the participant. Participants will eat breakfast and lunch in clinic.
Uric acid (UA) is the end product of purine metabolism. In recent years, UA has been found to be associated with the prognosis of clinical cancer patients. However, the intricate mechanisms by which UA affects the development and prognosis of tumor patients has not been well elucidated. In this study, we explored the role of UA in breast cancer, scrutinizing its impact on breast cancer cell function by treating two types of breast cancer cell lines with UA. The role of UA in the cell cycle and proliferation of tumors and the underlying mechanisms were further investigated. We found that the antioxidant effect of UA facilitated the scavenging of reactive oxygen species (ROS) in breast cancer, thereby reducing aryl hydrocarbon receptor (AhR) expression and affecting the breast cancer cell cycle, driving the proliferation of breast cancer cells through the AhR/p27Kip1/cyclin E1 pathway. Moreover, in breast cancer patients, the expression of AhR and its downstream genes may be closely associated with cancer progression in patients. Therefore, an increase in UA could promote the proliferation of breast cancer cells through the AhR/p27Kip1/cyclin E1 pathway axis.
The invention relates to methods and systems of unhindered construction and display of tethered organic ligand molecules, and more particularly to preparation and use of thin film, substantially non-crosslinked hydrophilic polar multi-functionalized polymers (HPMPs) anchored to a variety of functionalized substrates so that the HPMP forms a thin film matrix layer providing a unique highly hydrated, high dielectric environment equivalent to an aqueous solution, for affinity binding of Ligands (L) to Tagged Target Molecules (TTMs). Ligands, and especially MERn ligand libraries such as peptide libraries, are singly tethered to the HPMP by a "permanent" strong covalent bond so that subsequent displacement of the TTM does not also displace the ligand from the HPMP, thereby making the HPMP tethered Ligand library reusable. The HPMP thin film is on the order of 200-2000  ANGSTROM  thick, is highly accessible (to the TTMs), and permits flexible, 3-D display of the singly tethered ligands for free permeability therein of the TTMs for affinity binding. The 3-D nature of the HPMP film provides high amplification of display, and the open nature of the matrix permits rapid elution of excess TTMs and other molecules. Importantly, the HPMP matrix layer, while providing amplification is also non-masking, being essentially transparent to detection methods. The combination of the reuseability, amplification and non-masking properties results in a very significant, many-fold increase in sensitivity and speed of screening assays.
BACKGROUND: The relationship between healthy lifestyle and frailty remains unclear. Healthy weight is crucial for overall well-being, but using body mass index (BMI) to evaluate weight management is inefficient. This study clarifies the association between healthy lifestyle or its factors (non-smoking, moderate drinking, healthy weight, healthy diet, sufficeint physical activity, and non-sedentary) and frailty, and the feasibility of using the weight-adjusted waist index (WWI) reflecting central obesity as an intermediate indicator.
METHODS: This study included 4,473 participants from the 2007-2018 National Health and Nutrition Examination Survey (NHANES). Healthy lifestyle quality was assessed by summing the scores of each healthy lifestyle factor. Frailty was assessed using a 49-item frailty index (FI), categorizing participants into robust, pre-frail, and frail. Logistic regression to investigate the association between healthy lifestyle or its factors, WWI, and frailty. Smooth curve fitting and threshold effect analyses were used to elucidate the nonlinear association. Subgroup and two other sensitivity analyses were conducted to confirm the stability of the results. A causal mediation model examined the proportion of frailty mediated by WWI.
RESULTS: The study identified 13.98% of the participants as frail. Optimal healthy lifestyle and frailty were negatively associated (OR: 0.39, 95%CI: 0.27-0.58). Five healthy lifestyle factors (non-smoking, healthy weight, healthy diet, sufficient physical activity, and non-sedentary) were associated with a lower prevalence of frailty, with odds ratios (OR) ranging from 0.48 to 0.61. We also analyzed the association between a healthy lifestyle and WWI (OR: 0.32, 95%CI: 0.27-0.37), WWI and frailty (OR: 1.85, 95%CI: 1.59-2.16). A positive association between WWI and FI was observed beyond the inflection point (9.99) (OR: 0.03, 95%CI: 0.02-0.03). Subgroup and sensitivity analyses confirmed stable associations between healthy lifestyle, WWI, and frailty. WWI partially mediated the association between a healthy lifestyle and frailty (mediating ratio = 20.50-20.65%).
CONCLUSIONS: An optimal healthy lifestyle and positive healthy lifestyle factors are associated with a lower incidence of frailty. WWI may mediate the relationship between a healthy lifestyle and frailty.
The invention discloses a traditional Chinese medicine for treating stomach and intestine diseases caused by dry intestines and deficient body fluid. The traditional Chinese medicine is composed of the following traditional Chinese herbals in parts by weight: 3 to 5 parts of rheum officinale, 8 to 10 parts of safflower, 3 to 5 parts of tortoise plastron, 12 to 15 parts of couch grass root, 20 to 25 parts of eclipta prostrata, 25 to 30 parts of bunge cherry seed, 12 to 15 parts of Chinese magnoliavine, 3 to 5 parts of pyrrosia lingua, 12 to 15 parts of cyrtomium rhizome, 15 to 20 parts of red peony root, and 25 to 30 parts of toosendan fruit. The raw materials mentioned above are organically combine together, and each component can well cooperate with each other to generate a synergetic effect. The provided traditional Chinese medicine can treat both the symptom and root of the stomach and intestine diseases caused by dry intestines and deficient body fluid. The traditional Chinese medicine also has a very good body modulating effect. Through years, the long-term observation and statistic on 100 patients show that the effective rate of the traditional Chinese medicine can reach 100%, the significant efficiency rate can reach 100%, and the cure rate can reach 96%.
Malignant bile duct obstructions are caused by many diseases arising from primary or metastatic disease in intrahepatic, extrahepatic or hilar locations. To relieve obstructive decompression and jaundice as a result of the obstruction, endoscopic stent placement is usually required. Compared with surgical intervention, stent insertion offers shorter hospitalization, lower overall cost and lower morbidity. Previous studies have shown the superiority of SEMSs over plastic stents for maintaining biliary drainage. However, SEMS can occlude due to epithelial hyperplasia, tumor in-/overgrowth, biofilm deposition and sludge formation. Studies have showed that the median SEMS patency is 120 days. Once bile duct obstruction reoccurs, it may lead to significant morbidity and mortality. Thus, long-term patency of the SEMS remains an unresolved issue.

Recently, endoscopic biliary radiofrequency ablation (RFA) have been used in patients suffering from inoperable malignant bile duct obstruction, and increasing the duration of stent patency. It delivers a high amount of thermal energy to target tissue with curative or palliative intent. The purpose of this study is to record information and evaluate the impact of radiofrequency ablation in improving the management of cholangiocarcinoma or malignant bile duct obstruction, and to compare the effects of SEMS plus RFA to SEMS alone.
The present invention relates to method and kits for diagnosing and/or treating prostate cancer. The method and kit relate to the determination and/or modulation of the methylation degree of tumor suppressive genes in biological samples. More particularly, CpG-methylation of 14-3-3σ was found in all primary PCa samples analysed, but not in matching normal prostate epithelial cells or benign prostate hyperplasia (BPH). CpG-methylation was accompanied by a decrease or loss of 14-3-3σ protein expression in primary PCa and PCa cell lines. PCa-precursor lesions, known as prostatic intraepithelial neoplasia (PIN), also displayed decreased levels of 14-3-3σ expression, whereas normal prostate epithelial cells and BPH showed high levels of 14-3-3σ protein expression. The generality of CpG-methylation in PCa suggests that silencing of 14-3-3σ significantly contributes to the formation of PCa. Furthermore, the CpG-methylation of 14-3-3σ in PCa may be exploited for diagnostic purposes.
PURPOSE:A remedy, containing taurine as an active constituent without side effects, and effective for the cardiac insufficiency. CONSTITUTION:A remedy for the cardiac insufficiency containing taurine (2- aminoethanesulfonic acid) as an active constituent. In use, the remedy is administered alone or used together with another remedy for the cardiac insufficiency. The remedy is administered to humans by a suitable method of administration,e.g. oral administration or intravenous injection, etc. The dosage form thereof may be the taurine as it is, but usually used in the form of a granule, fine granule, powder, capsule or injection, which are prepared by the cnventional method. The dose is 0.5-12g active constituent per adult once a day or divided into 2-4 portions.
PURPOSE: A novel composite using anthocyanine and anionic polysaccharides is provided to prevent decomposition by anthocyanine hydration and to enhance structural stabilty of anthocyanine. CONSTITUTION: An anthocyanine-polysaccharide composite contains anthocyanine and anionic polysaccharides which are combined by ion bond. The anionic polysaccharide contains sulfate group or carboxy group. The anionic polysaccharide is hyaluronic acid, o-sulfated hyaluronic acid, dextran sulfate, chondroitin sulfate, dermatan sulfate, keratin sulfate, heparin, heparin sulfate, alginic acid, a mixture thereof, or complex thereof. The composite additioinally contains biocompatible or biodegradable carriers. The carrier is a liposome, micelle, or neutralized vesicle. A pharmaceutical, cosmetic, or food composition contains the composite.
These subjects will receive the following: 1) data about clinical movement disorder history, age, gender, height, weight, and other medical conditions; 2) clinical neurological examination; 3) tests assessing cognitive abilities including: the Montreal Cognitive Assessment, Stroop, Digit Span, and Brief Test of Attention (BTA); 4) measures of anxiety and depression: the Beck Depression Index (BDI II). Only participants aged 18+ will be given the BDI; 5) Functional magnetic resonance imaging (fMRI) and structural MRI will be performed; and 6) Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) to assess dystonia severity.
The present invention relates to a pure Chinese medicine preparation which is a recipe of medicine with quantitative antiendotoxic action; 2727g of honeysuckle, 2727g of forsythia, 1364g of scutellaria, 11.36g of sodium decanoyl acetaldehyde, 1636g of red peony and 909g of rhubarb are made into a capsule. The present invention has the advantages of reasonable prescription and obvious therapeutic effects. The pure Chinese medicine preparation is a pure green packing plant preparation and has the advantages of small side effects, safety, reliability and techniques purification technology. Proved by an experiment, the pure Chinese medicine preparation has specific active components. The pure Chinese medicine preparation has the action mechanism of directly eliminating endotoxin and is breakthrough contribution to medicine history. The pure Chinese medicine preparation acts on the middle link of an inflammation reaction, takes effect quickly, avoids serious complicating diseases such as shock, DIC, MSOF, etc., induced by the increase of the endotoxin, and eliminates the effect of the endotoxin. The pure Chinese medicine preparation is verified by a scientific test method. The pure Chinese medicine preparation does not have medicine resistance performance and is non hormone medicine. The present invention adjusts the immunological function of an organism and enhances antiendotoxic sterilization efficacy.