anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a novel indoleamine-2, 3-dioxygenase (IDO) inhibitor, a preparation method therefor, and the uses thereof. The inhibitor is a compound as represented by formula (I) or a salt, a solvate, a polymorph, an enantiomer, or a racemic mixture pharmaceutically acceptable thereto. R 1  or R 2  is independently selected from hydrogen, a C 1 -C 5  alkyl group, a halogen, and a substituent group as represented by formula (II), and one of the R 1  and the R 2  is the substituent group as represented by formula (II). R 3  is selected from an aryl group, and n=0, 1, 2, or 3. Compared with a known IDO inhibitor, the novel inhibitor has a more powerful IDO inhibitory effect, and can be used to treat diseases having a pathological feature of an IDO-mediated tryptophan metabolic pathway, for example, tumors, cancers, Alzheimer disease, autoimmune diseases, cataract, mental disorders, depression, and/or anxiety disorders. The preparation method therefor has the advantages of easy operation and a mild reaction condition, and saves the solvent and reduces pollution, thereby facilitating industrial production.
BACKGROUND: Obesity, a global chronic disease, has been recognized as a severe risk to health. In our study, a novel polysaccharide named ARS was isolated and purified from aerial part of salviae miltiorrhizae radix. Our aim is to investigate the weight-reducing effect of a polysaccharide from salviae miltiorrhizae radix on mice fed a high-fat diet.
RESULTS: The novel polysaccharide ARS mainly consisted of glucose and galactose with a molar ratio of 0.59:1.00. We found that treatment with ARS could inhibit weight gain of mice fed a high-fat diet via modulating the intestinal bacteria. Moreover, we surveyed its mechanism in mice, and the gut microbiota sequencing results demonstrated that ARS can reverse or resist high-fat-diet-induced significant weight gain or obesity by increasing the diversity of gut microbiota and optimizing the ratio of Firmicutes to Bacteroidetes. Phylum and species analysis of gut microbiota demonstrated that obesity caused by a high-fat diet was accompanied by significant changes in the microbial communities, but ARS could reverse the disturbance of gut microbiota induced by the high-fat diet to maintain homeostasis.
CONCLUSION: Overall, our findings suggested a new function of ARS in regulating gut microbiota, which provides a theoretical basis for the development of high-quality ARS functional foods and the application of dietary supplements. © 2023 Society of Chemical Industry.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of trimethoprim tablets, USP and other antibacterial drugs, trimethoprim tablets, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

For the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus. 

Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to trimethoprim. Therapy may be initiated prior to obtaining the results of these tests.
BACKGROUND: Ischemic stroke is a common neurovascular disorder with high morbidity and mortality. However, the underlying mechanism of stereotactically intracerebral transplantation of human neural stem cells (hNSCs) is not well elucidated.
MATERIALS AND METHODS: Four days after ischemic stroke induced by Rose Bengal photothrombosis, seven cynomolgus monkeys were transplanted with hNSCs or vehicles stereotactically and followed up for 84 days. Behavioral assessments, magnetic resonance imaging, blood tests, and pathological analysis were performed before and after treatment. The proteome profiles of the left and right precentral gyrus and hippocampus were evaluated. Extracellular vesicle micro-RNA (miRNA) from the peripheral blood was extracted and analyzed.
RESULTS: hNSC transplantation reduced the remaining infarcted lesion volume of cynomolgus monkeys with ischemic stroke without remarkable side effects. Proteomic analyses indicated that hNSC transplantation promoted GABAergic and glutamatergic neurogenesis and restored the mitochondrial electron transport chain function in the ischemic infarcted left precentral gyrus or hippocampus. Immunohistochemical staining and quantitative real-time reverse transcription PCR confirmed the promoting effects on neurogenesis and revealed that hNSCs attenuated post-infarct inflammatory responses by suppressing resident glia activation and mediating peripheral immune cell infiltration. Consistently, miRNA-sequencing revealed the miRNAs that were related to these pathways were downregulated after hNSC transplantation.
CONCLUSIONS: This study indicates that hNSCs can be effectively and safely used to treat ischemic stroke by promoting neurogenesis, regulating post-infarct inflammatory responses, and restoring mitochondrial function in both the infarct region and hippocampus.
Inflammatory bowel diseases (IBDs) are complex disorders. Iron accumulates in the inflamed tissue of IBD patients, yet neither a mechanism for the accumulation nor its implication on the course of inflammation is known. We hypothesized that the inflammation modifies iron homeostasis, affects tissue iron distribution, and that this in turn perpetuates the inflammation. This study analyzed human biopsies, animal models, and cellular systems to decipher the role of iron homeostasis in IBD. We found inflammation-mediated modifications of iron distribution, and iron-decoupled activation of the iron regulatory protein (IRP) 1. To understand the role of IRP1 in the course of this inflammation-associated iron pattern, a novel cellular coculture model was established, which replicated the iron-pattern observed in vivo, and supported involvement of nitric oxide in the activation of IRP1 and the typical iron pattern in inflammation. Importantly, deletion of IRP1 from an IBD mouse model completely abolished both, the misdistribution of iron and intestinal inflammation. These findings suggest that IRP1 plays a central role in the coordination of the inflammatory response in the intestinal mucosa and that it is a viable candidate for therapeutic intervention in IBD.
This is a single group study. 8 participants will be recruited and will receive the same intervention of physiological data collection using Bodytrak.
Participants randomly assigned to this group will be provided with a MP3 Player which will have three guided imagery programs The Guided Imagery Programs include: 1.) Relaxation and Wellness; 2.) Immune System Imagery; and 3.) Healing Trauma.
Participants in the controlled breathing intervention will be provided with headphones to listen to the guided intervention audio file. Over the course of the 25-60-minute procedure, approximately 50% of the intervention will be spent completing controlled breathing. The other 50% of the intervention will be spent listening to music, which is part of usual care. Music options will include instrumental jazz, classical piano, harp and flute, nature sounds, and world music.
An interventional randomised control trial that will include 374 participants who will be healthcare workers at variable risks of exposure to SARS-CoV-2 while managing patients both suspected and confirmed with COVID-19 infection.Each participant will undergo detailed clinical evaluation to confirm eligibility, complete blood count, retinal imaging and ECG rhythm lead at baseline. A nasopharyngeal swab for reverse-transcriptase-polymerase chain reaction (RT-PCR) will also be taken. The enrolled participants will be randomised to two treatment arms with the experimental arm receiving Tab.Hydroxychloroquine (HCQ) 400mg twice a day on day 1 followed by 400mg weekly for 11 weeks. The placebo comparator arm will receive 2 tablets twice daily on day 1 followed by 2 tablets weekly for 11 weeks. The participants will be followed up via phone call weekly to ensure drug compliance, occurrence of drug-related side effects or respiratory symptoms. The final visit 4 will mark the end of study at 12 weeks from randomisation when a repeat nasopharyngeal swab for SARS-CoV-2 RT-PCR will be taken.The primary outcome measures will be prevention of SARS-CoV-2 infection as determined by a negative RT-PCR in the experimental arm at the end of 12 weeks and HCQ safety as determined by occurrence of adverse events.
NEW MATERIAL:An acetic acid derivative expressed by formula I (RIC is aminoalkyl or protected aminoalkyl) and salt thereof. EXAMPLE:2-[2-(tert-Butoxycarbonylamino)ethoxyimino]-2-(4-thiazolyl)acetic acid. USE:Useful as an antimicrobial agent, capable of inhibiting growth of a wide range of pathogenic germs including Gram-positive and Gram-negative bacteria and used as an antimicrobial substance. PREPARATION:For example, a compound expressed by formula II or a salt thereof is reacted with a compound expressed by formula III or salt thereof to afford the aimed compound expressed by formula I. The above-mentioned reaction is normally carried out in the presence of a base, e.g. sodium hydroxide, etc., when the salt expressed by formula III is used therein. Furthermore, the reaction is preferably carried out in a solvent, e.g. water, methanol, etc., at about room temperature.
Kinesio taping was also applied once a week, for a total of 5 sessions. The rake method was used for kinesio taping.
Patients in this group are to receive a single dose of TACE treatment on day 1. TACE treatment is repeated every 9 weeks for 27 weeks.
The invention relates to a traditional Chinese medicine used for treating yin-deficiency-type cough. The traditional Chinese medicine is prepared from the raw materials of, by weight, 12-35g of raw Mongolian milkvetch root, 10-40g of ligusticum, 10-40g of Hangzhou peony, 8-30g of Szechwan lovage rhizome, 15-40g of raw rehmannia, 15-40g of prepared rehmannia, 6-35g of Chinese magnoliavine fruit, 10-30g of tendrilleaf fritillary bulb, and 10-35g of ophiopogogon japonicas. The traditional Chinese medicine is prepared from 9 medicine materials, and has the functions of qi nourishing, lung moistening, yin nourishing, body fluid regenerating, cough relieving, and phlegm dissipating. With the medicine, body immunity is greatly improved, and a good treatment effect is provided for yin-deficiency-type cough. Especially, the medicine has a unique treatment effect against severe cough at night and cough when falling into sleep. The medicine has the advantages of fast effect, short treatment cause, high curative rate, low cost, and the like.
PROBLEM TO BE SOLVED: To obtain a detergent compsn. which has a high affinity for makeup stain, hair protecting agents, sebum, or the like, and hence can perform quick and effective cleaning by incorporating a noionic surfactant and a silane or silicone having at least one hydroxyl group into the same. SOLUTION: A silane or silicone represented by formula I or II is suitable. In the formulas, each R group is independently an optionally substd. 1-14C alkyl, cycloalkyl, alkyl ether group or the like provided at least one of all the R groups is a hydroxylated alkyl or alkyl ether group; and (n) is an integer of 1-4. The silane or silicone is contained in an amt. of 0.5-50 wt.% in the compsn. Any nonionic surfactant can be used without any specific limitation, fatty acid esters (e.g. sorbitan monolaurate) being examples. The content of the nonionic surfactant in the compsn. is pref. 0.02-80 wt.%.
PURPOSE:To make it possible to nip and fix a different electrode having a drug storage layer stuck with ionic drugs, an electrode phase and a backing layer at a narrow point by fixing the backing layer of this different electrode to the end of one clamping part of a nipping means and providing the different electrode with an indifferent indifferent electrode having a conductive layer, electrode layer and base layer. CONSTITUTION:The different electrode 2 fixed to the one clamping part of the nipping means has the drug storage layer stuck or dispersed with the ionic drugs or the drugs, the electrode layer and the backing layer and is fixed to the one clamping part by the backing layer. The indifferent electrode 3 fixed to the end of the other clamping part of the clamping means has the conductive layer, the electrode layer and the base layer and is fixed by the base layer. A power source part 4, such as dry cell, supplies electrode/voltage between the respective electrode layers of the different electrode 2 and the indifferent electrode 3. A pulse oscillator 5 oscillates DC pulses of, for example, 1000Hz to 100kHz. A switch part 6 depolarizes the polarization potential of the different electrode 2 and the indifferent electrode 3 simultaneously with pause of the treatment pulse voltage outputted from this pulse oscillator 5.
Breast tumor-initiating cells (BTICs) of triple-negative breast cancer (TNBC) tissues actively repair DNA and are resistant to treatments including chemotherapy, radiotherapy, and targeted therapy. Herein, it is found that a previously reported secreted protein, sclerostin domain containing 1 (SOSTDC1), is abundantly expressed in BTICs of TNBC cells and positively correlated with a poor patient prognosis. SOSTDC1 knockdown impairs homologous recombination (HR) repair, BTIC maintenance, and sensitized bulk cells and BTICs to Olaparib. Mechanistically, following Olaparib treatment, SOSTDC1 translocates to the nucleus in an importin-α dependent manner. Nuclear SOSTDC1 interacts with the N-terminus of the nucleoprotein, chromatin helicase DNA-binding factor (CHD1), to promote HR repair and BTIC maintenance. Furthermore, nuclear SOSTDC1 bound to β-transducin repeat-containing protein (β-TrCP) binding motifs of CHD1 is found, thereby blocking the β-TrCP-CHD1 interaction and inhibiting β-TrCP-mediated CHD1 ubiquitination and degradation. Collectively, these findings identify a novel nuclear SOSTDC1 pathway in regulating HR repair and BTIC maintenance, providing insight into the TNBC therapeutic strategies.
A solid phase substrate which yields soluble labeled products upon hydrolysis by a glycosaminoglycan endoglycosidase and methods of producing said substrate are comprised in the present invention. The solid phase substrate comprises glycosaminoglycan bearing labeled substances bound to amino groups. The labeled glycosaminoglycan substrate is reductively aminated at its reducing terminal end to produce an amine-terminus. The substrate is further coupled to an amino-reactive solid matrix through its amine-terminus. A method of producing the solid phase substrate comprises the steps of: at least partially N-desulfating or N-deacylating a glycosaminoglycan; labeling at least partially N-deacylated or N-desulfated glycosaminoglycan with a substance yielding detectable signals to produce labeled glycosaminoglycan; completely N-acylating the labeled glycosaminoglycan with acyl anhydride or acyl halide; reductively aminating a reducing terminal end of said labeled glycosaminoglycan to produce labeled amine-terminal glycosaminoglycan; and coupling, through its terminal amine, the labeled amine-terminal glycosaminoglycan to an amino-reactive solid phase support to produce the solid phase substrate. The solid phase substrate is usable to detect metastatic tumors by measurement of serum heparanase levels. The potential metastases of a tumor may also be determined by its heparanase levels.
All patients will be administered BMX-001 + PTX weekly on Days 1, 8, 15, and 22 of each 28 day cycle. BMX-001 is a SC injection while PTX is IV.
Example systems, methods, and apparatus for application state capture and playback are provided. An example system includes a user interface to display an application and associated data to a user for interaction by the user. The user interface includes a player to facilitate playback of one or more saved states from the application; each of the saved state(s) includes an application setting and associated data. The player is to include a plurality of controls to facilitate selection, playback, and modification of each of the saved state(s). The player is to provide a list of saved state(s) for selection and playback by the user. The playback of a selected state is to automatically take the user to a point in the application execution associated with the application setting and associate data and to allow the user to dynamically execute the application from that point.
In a single-blinded randomized crossover study, inspired oxygen/air (40%/21%) is delivered on two separate nights. Loop gain is measured from routine polysomnography using a novel mathematical method. A value of loop gain \>1 reflects unstable breathing, and a value less than but approaching 1 denotes a system more prone to oscillate. Loop gain is measured as the changes in ventilatory drive/effort that arises subsequent to changes in ventilation (e.g. due to obstructive apnea). A simple chemoreflex model (gain, time constant, delay) is fit to surrogate ventilation data (derived from airflow) during sleep. The best model is one that best matches the elevated ventilatory drive (measured as ventilation in the absence of airflow obstruction) based on the prior apneic/hypopneic fall in ventilation. Loop gain is calculated from this model. We aim to use loop gain measured on and off oxygen to determine whether a strong response (reduction in apnea severity) can be predicted by a higher loop gain (in the sham arm) using our method. We also assessed whether assessing upper airway anatomy/collapsibility, dilator muscle responsiveness, and the arousal threshold helped to predict responses to treatment.
2.0) HEPTANE DERIVATIVES. FIELD: chemical industry. SUBSTANCE: described are new N-substituted 3-azabicyclo (3.2.0) heptane derivatives of formula I:   wherein R is naphthyl or phenanthryl group which is mono-or disubstituted by halogen atoms; A is residue of formula or naphthyl group which are substituted by halogen, or salts thereof with physiologically acceptable acids. Said compounds are useful as neuroleptic agents. EFFECT: improved properties of the title compounds. 2 cl, 1 ex, 1 tbl
Eosinophils account for a significant portion of immune cells in the body. It is well known that eosinophils play a role in the pathogenesis of many diseases. In which the interaction between eosinophils and other immune cells is incompletely understood. The aim of this study is to characterize the immune suppressive functions of eosinophils. In this study, an irway allergy mouse model was established. Eosinophils were isolated from the airway tissues using flow cytometry cell sorting. The RAW264.7 cell line was used to test the immune suppressive functions of eosinophils. We observed that eosinophils had immune suppressive functions manifesting inhibiting immune cell proliferation and cytokine release from other immune cells. The eosinophil's immune suppressive functions were mediated by eosinophil-derived molecules, such as eosinophil peroxidase (EPX) and major basic protein (MBP). The expression of Ras-like protein in the brain 27a (Rab27a) was detected in eosinophils, which controlled the release of MBP and EPX by eosinophils. Eosinophil mediators had two contrast effects on inducing inflammatory responses or rendering immune suppressive effects, depending on the released amounts. Administration of an inhibitor of Rab27a at proper dosage could alleviate experimental airway allergy. To sum up, eosinophils have immune suppressive functions and are also inflammation inducers. Rab27a governs the release of EPX and MBP from eosinophils, which leads to immune suppression or inflammation. Modulation of Rab27a can alleviate airway allergy responses by modulating eosinophil's immune suppressive functions, which has the translational potential for the management of eosinophil-related diseases.
Studies on the reading acquisition of deaf children investigate the similarities and differences in the reading process between these readers and typical hearing readers. There is no consensus on the nature of the reading process among deaf readers, whether they use the same reading processing strategies as typical readers or depend on other strategies to close the gap. The present study aimed to test the types of strategies used to process written words by deaf Arabic readers with prelingual deafness, compared to their hearing peers, and to test the effectiveness of deaf readers' use of these strategies. Three experimental paradigms were tested. The findings indicated that deaf Arabic readers rely on essentially similar processing strategies to those used by hearing readers. However, deaf Arabic readers employ these strategies with significantly less effectiveness. The results are discussed in light of international data.
We designed this multi-center prospective study with the following objectives: (1) the cross-sectional validation of extracellular vesicles (EV) mRNA markers to detect urothelial bladder cancer (UBC) before transurethral resection of bladder cancer (TURBT), and (2) the longitudinal validation of EV mRNA markers to monitor non-muscle invasive bladder cancer (NMIBC) recurrence after TURBT. EV mRNA markers evaluated in this study were KRT17, GPRC5A, and SLC2A1 in addition to two additional markers from literatures, MDK and CXCR2, and measured by quantitative RT-PCR with normalization by a reference gene (ALDOB). Diagnostic performances of EV mRNA markers were compared to conventional markers. Regarding the first objective, we confirmed that EV mRNA biomarkers in urine were higher in UBC patients, particularly those with higher stage/grade tumors, than in those without UBC (n = 278 in total) and the diagnostic performance of EV mRNA MDK and KRT17 outperformed conventional biomarkers with AUC 0.760 and 0.730, respectively. Concerning the second objective, we prospectively analyzed the time courses of EV mRNA markers while NMIBC patients (n = 189) (median follow-up 19 months). The expression of EV mRNA KRT17 was significantly high in patients with recurrence, while it gradually decreased over time in those without recurrence (p < 0.01).
Diabetes mellitus (DM) is a chronic disease characterized by persistent hyperglycemia, which is a major contributing factor to chronic kidney disease (CKD), end-stage renal disease (ESRD), and cardiovascular-related deaths. There are several mechanisms leading to kidney injury, with hyperglycemia well known to stimulate oxidative stress, inflammation, tissue remodeling, and dysfunction in the vascular system and organs. Increased reactive oxygen species (ROS) decrease the bioavailability of vasodilators while increasing vasoconstrictors, resulting in an imbalance in vascular tone and the development of hypertension. Treatments for diabetes focus on controlling blood glucose levels, but due to the complexity of the disease, multiple drugs are often required to successfully delay the development of microvascular complications, including CKD. In this context, naringenin, a flavonoid found in citrus fruits, has demonstrated anti-inflammatory, anti-fibrotic, and antioxidant effects, suggesting its potential to protect the kidney from deleterious effects of diabetes. This review aims to summarize the scientific evidence of the effects of naringenin as a potential therapeutic option for diabetes-induced CKD.