anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain an anticancer agent containing a specific benzoylurea based compound as an active ingredient, capable of enhancing biological utilization ratio by improving absorbing properties into blood and effectively raising concentration in blood and limited for administration after eating. CONSTITUTION:The aimed agent containing a compound expressed by the formula (X is halogen or nitro; Y is H, halogen, nitro, etc.; Z1 is halogen, etc.; Z2 is H or halogen; A is CH or N) as an active agent. An agent obtained by crushing the compound expressed by the formula in an aqueous suspension to which a dispersing agent is added, adding a disintegrator thereto and subjecting the blend to lyophilization is preferably used as the above-mentioned anticancer agent. The above-mentioned compound expressed by the formula is preferably used in form as fine as possible. Polyoxyethylene hardened castor oil, etc., is preferably used as the dispersing agent. The compound expressed by the formula is administered normally in dose of about 1-100mg/kg adult day divided 2-3 times from immediately after eating to about 2 hr after eating. A food having high fat content is preferably used as the food.
Osteonecrosis (ON) of the femoral head (ONFH) is a devastating bone disease affecting over 20 million people worldwide. ONFH is caused by a disruption of the blood supply, leading to necrotic cell death and increased inflammation. Macrophages are the key cells mediating the inflammatory responses in ON. It is unclear what the dynamic phenotypes of macrophages are and what mechanisms may affect macrophage polarization and, therefore, the healing process. In our preliminary study, we found that there is an invasion of macrophages into the repair tissue during ON healing. Interestingly, in both ONFH patients and a mouse ON model, fat was co-labeled within macrophages using immunofluorescence staining, indicating the phagocytosis of fat by macrophages. To study the effects of fat phagocytosis on the macrophage phenotype, we set up an in vitro macrophage and fat co-culture system. We found that fat phagocytosis significantly decreased M1 marker expression, such as IL1β and iNOS, in macrophages, whereas the expression of the M2 marker Arg1 was significantly increased with fat phagocytosis. To investigate whether the polarization change is indeed mediated by phagocytosis, we treated the cells with Latrunculin A (LA, which inhibits actin polymerization and phagocytosis). LA supplementation significantly reversed the polarization marker gene changes induced by fat phagocytosis. To provide an unbiased transcriptional gene analysis, we submitted the RNA for bulk RNA sequencing. Differential gene expression (DGE) analysis revealed that the top upregulated genes were related to anti-inflammatory responses, while proinflammatory genes were significantly downregulated. Additionally, using pathway enrichment and network analyses (Metascape), we confirmed that gene-enriched categories related to proinflammatory responses were significantly downregulated in macrophages with fat phagocytosis. Finally, we validated the similar macrophage phenotype changes in vivo. To summarize, we discovered that fat phagocytosis occurs in both ONFH patients and an ON mouse model, which inhibits proinflammatory responses with increased anabolic gene expression in macrophages. This fat-phagocytosis-induced macrophage phenotype is consistent with the in vivo changes shown in the ON mouse model. Our study reveals a novel phagocytosis-mediated macrophage polarization mechanism in ON, which fills in our knowledge gaps of macrophage functions and provides new concepts in macrophage immunomodulation as a promising treatment for ON.
3-Methylflavone-8-carboxylic acid esters I are provided. They may be prepared by condensing a 3-methylflavone-8-carboxylic acid halide (preferably the chloride with an aminoalcohol ZOH. Condensation conditions are (a) no solvent, 140-200°C, excess flavone derivative or (b) organic solvent, 0°C to reflux, equimolar reactant proportions, hydrogen halide acceptor optional. The esters have muscle relaxant and calcium blocking action. They are also anaesthetics and anti-inflammatory agents. Z = N-methylpiperidyl, tropyl, quinuclidyl or
Death has followed ingestion of 10 to 30 g of salicylates in adults, but much larger amounts have been ingested without fatal outcome.

Symptoms: The usual symptoms of salicylism - tinnitus, vertigo, headache, confusion, drowsiness, sweating, hyperventilation, vomiting and diarrhea - will occur. More severe intoxication will lead to disruption of electrolyte balance and blood pH, and hyperthermia and dehydration.

Treatment: Further absorption of salsalate from the G.I. tract should be prevented by emesis (syrup of ipecac), and, if necessary, by gastric lavage.

Fluid and electrolyte imbalance should be corrected by the administration of appropriate I.V. therapy. Adequate renal function should be maintained. Hemodialysis or peritoneal dialysis may be required in extreme cases.
Background: The doctor-patient relationship, medical competence and patient expectations influence patient satisfaction with anesthesia. Preoperatively all patients are routinely assessed by an anesthesiologist. However, in many centers, the anesthesiologist who performs the preoperative evaluation will not necessarily be the anesthesiologist who provides the intraoperative service. This study evaluated the effect of this practice on patient satisfaction, level of confidence and anxiety among adult patients undergoing elective surgery.

Methods: 100 patients scheduled for elective surgery under general anesthesia were randomly divided into 2 equal groups: In Group A patients were evaluated and anesthetized by the same anesthesiologist. In Group B the preoperative assessment and actual anesthesia was performed by two different anesthesiologists. On the first postoperative day all patients completed a questionnaire designed to evaluate their sense of preoperative security (confidence) and their overall satisfaction with the anesthetic experience.
BACKGROUND: Atrial fibrillation (AF) is the most common type of arrhythmia worldwide and is associated with serious complications. This study investigated the metabolic biomarkers associated with AF and the differences in metabolomics and associated metabolic biomarkers between paroxysmal AF (AFPA) and persistent AF.
METHODS AND RESULTS: Plasma samples were prospectively collected from patients with AF and patients in sinus rhythm with negative coronary angiography. The patients were divided into 3 groups: AFPA, persistent AF, and sinus rhythm (N=54). Metabolomics (n=36) using ultra-high-performance liquid chromatography mass spectrometry was used to detect differential metabolites that were validated in a new cohort (n=18). The validated metabolites from the validation phase were further analyzed by receiver operating characteristic. Among the 36 differential metabolites detected by omics assay, 4 were successfully validated with area under the curve >0.8 (P<0.05). Bioinformatics analysis confirmed the enrichment pathways of unsaturated fatty acid biosynthesis, glyoxylate and dicarboxylate metabolism, and carbon metabolism. Arachidonic acid was a potential biomarker of AFPA, glycolic acid and L-serine were biomarkers of AFPA and persistent AF, and palmitelaidic acid was a biomarker of AFPA.
CONCLUSIONS: In this metabolomics study, we detected 36 differential metabolites in AF, and 4 were validated with high sensitivity and specificity. These differential metabolites are potential biomarkers for diagnosis and monitoring of disease course. This study therefore provides new insights into the precision diagnosis and management of AF.
Healthy volunteers who express an interest in the study and meet the eligibility criteria will be invited to participate in the study. This study will investigate the accuracy and safety of the SurePulse VS and SurePulse VS Patch (VSP) in measuring blood oxygen levels. This is done by measuring blood oxygen levels across a range of values in healthy adults. The measurements from the VS and VSP will be compared to the known correct value. The study follows the internationally agreed standard for pulse oximeter approval.

Agreeing participants will have their name, contact details, medical history, height, weight, date of birth, skin colour, emergency contact details and address recorded, as necessary to conduct the study. After completion of the eligibility and consent process, participants will be enrolled in the study. Healthy volunteers will have their blood oxygen levels temporarily reduced in a controlled and stepwise manner. Oxygen levels will not be low for the entire duration of the session. Oxygen levels will be reduced to a specific target for a few minutes at a time. Volunteers will have a small tube inserted into an artery (blood vessel) in their wrist; this will be used to take blood samples throughout the session. The blood samples will be taken, analysed and destroyed in the same room. The session should take approximately 1.5 - 2 hours in total.

The output from the study will be compared to the primary and secondary outcomes to evaluate the performance and safety of the device. This study is required for the SurePulse VSP to be regulatory approved, meaning it could then become available in the NHS.
Patients received a higher dose of vorinostat at 230 mg/m\^2/day PO on Monday through Friday weekly for the duration of radiation therapy (6-7 weeks). Patients underwent 3D conformal or intensity-modulated radiation therapy 5 days per week for 6 weeks. After completing concurrent vorinostat and radiation therapy, patients then received maintenance therapy comprising of vorinostat at 230 mg/m\^2/day PO on days 1-28. Treatment repeats every 28 days for up to 12 courses in the absence of disease progression or unacceptable toxicity.
Upregulation of homeoprotein SIX1 in gastric cancer (GC) is related to tumour proliferation and invasion. MicroRNA-7160 (miR-7160) is a homeoprotein SIX1-targeting miRNA that downregulates miR-7160, leading to cancer development. Total gastric cancer samples were collected from six patients, and relative expression levels of SIX1 mRNA and miRNAs were analysed by qRT-PCR. To evaluate the regulation of SIX1 by miR-7160, pGL3-SIX1-mut, pGL3-SIX1, and miR-7160 mimics transfected into cells using lipofectamine 2000. After transfection, proliferation and apoptosis in cultured cells were assessed using the nuclear TUNEL staining and CCK8 reagent, respectively. We demonstrated that the downregulation of miR-7160 in human gastric cancer cells is related to the upregulation of SIX1 mRNA. In gastric cancer cell lines, miR-7160 overexpression could downregulate the expression and inhibit cancer cell proliferation and growth in vitro. However, overexpression of miR-7160 did not increase gastric cancer cell apoptosis. In vitro downregulation of SIX1 decreased vimentin, N-cadherin, and other EMT-related gene expression and increased E-cadherin expression. In brief, miR-7160, by targeting SIX1, inhibits gastric cancer proliferation and cell growth in vitro, which provides an idea for introducing a new treatment option for gastric cancer.
Disclosed is a preparation drug of precursor multiphase liposome of water grind processing  thistle bingham, which contains the precursor multiphase liposome of the water grind processing  thistle bingham. The preparation drug is mainly composed of the following mass abundance components : 1 portion of water grind processing  thistle bingham, 2 to 10 portions of  phospholipid, 0.1 to 0.6 portion of cholesterol, 1 to 5 portions of isopropyl myristate, 1 to 5 portions of sodium cholate, and 2 to 10 portions of cane sugar powder. Observed by the sem, the appearance of the prepared precursor multiphase liposome powder of the water grind processing  thistle bingham is ball-shaped or similar to the shape of the ball; the surface of the prepared precursor multiphase liposome powder of the water grind processing  thistle bingham is  smooth; the particle size and the distribution of the prepared precursor multiphase liposome powder of the water grind processing  thistle bingham are measured by photon correlation spectroscopy, and the average particle size is 106 nm; the redispersion in the water is good; no burst effect occurs; and the storage stability is good. The total entrapment efficiency of the precursor multiphase liposome of the water grind processing  thistle bingham is 96 percent, wherein, 85 percent of the water grind processing  thistle bingham is entrapped inside the liposome, and a small part is entrapped inside emulsion and micelle. With high entrapment efficiency, good stability, simple operation and low cost, the precursor multiphase liposome of the water grind processing  thistle bingham is easy to be filled , does not need special equipment and is convenient for industrial production. The invention discloses the preparation method of the precursor multiphase liposome of the water grind processing  thistle bingham.
Hepatocellular carcinoma (HCC) affects approximately 800,000 individuals globally each year. Despite advancements in HCC treatments, there is still a pressing need to identify new drugs that can combat resistance. One potential option is echinacoside, a natural caffeic acid glycoside with antioxidant, anti-inflammatory, antidepressant, and antidiabetic properties. Therefore, we aimed to investigate the ability of echinacoside to exhibit antitumor activity against HCC in rats through ameliorating hepatic fibrosis and tumor invasion. Rats were given thioacetamide to induce HCC, and some were given 30 mg/kg of echinacoside twice a week for 16 weeks. The liver impairment was assessed by measuring serum α-fetoprotein (AFP) and examining liver sections stained with Masson trichrome or anti-transforming growth factor (TGF)-β1 antibodies. The hepatic expression of mRNA and protein levels of TGF-β1, β-catenin, SMAD4, matrix metalloproteinase-9 (MMP9), phosphoinositide 3-kinases (PI3K), mammalian target of rapamycin (mTOR), connective tissue growth factor 2 (CCN2), E-Cadherin, platelets derived growth factor (PDGF)-B and fascin were also analyzed. Echinacoside improved the survival rate of rats by decreasing serum AFP and the number of hepatic nodules. Examination of micro-images indicated that echinacoside can reduce fibrosis. It also significantly decreased the expression of TGF-β1, β-catenin, SMAD4, MMP9, PI3K, mTOR, CCN2, PDGF-B, and fascin while enhancing the expression of E-Cadherin. In conclusion, echinacoside exhibits a protective effect against HCC by increasing survival rates and decreasing tumor growth. It also acts as an inhibitor of the hepatic tissue fibrosis pathway by reducing the expression of TGF-β1, β-catenin, SMAD4, PI3K, CCN2, PDGF-B and mTOR. Additionally, it prevents tumor invasion by suppressing MMP9 and fascin, and increasing the expression of E-Cadherin.
<P>PROBLEM TO BE SOLVED: To provide a new peptide and uses thereof.  <P>SOLUTION: This new peptide and a DNA encoding the same are provided. A drug comprising the peptide or DNA and a method for screening/a kit for screening a compound promoting or inhibiting the activity of the peptide or its salt are provided. The compound obtained by the screening or its salt, the drug, etc., comprising the compound or its salt are provided. Thereby, the peptide and DNA encoding the same can be used for, e.g. diagnosis, treatment, prophylaxis, etc., of digestive system diseases, etc. The peptide is useful as a reagent for screening the compound promoting or inhibiting the activity of a receptor protein to which the peptide is capable of binding or its salt.  <P>COPYRIGHT: (C)2003,JPO
Measures of life outlook in older adults have been investigated in connection to pain, as both pain management and outlook are important factors of successful aging. We hypothesized that higher pain is associated with lower optimism among community-dwelling older adults. We utilized data from the UC San Diego Successful Aging Evaluation (SAGE), a prospective longitudinal cohort study initiated in 2010, to evaluate the relationship between pain and optimism in 378 community-dwelling adults aged ≥50 years. We used the revised Life Orientation Test (LOT-R) to measure optimism and three pain subscales-PROMIS Pain Interference, PROMIS Pain Intensity, and MOS 36-Item Short-Form Health Survey (SF-36)-as pain measures. Regression analyses reveal negative relationships between pain and optimism for all three pain scales, with regression coefficients of -0.277 (p < .0001), -0.246 (p < .0001), and 0.269 (p < .0001) respectively. This indicates value in considering physical and psychological elements in future intervention research to promote healthy aging.
Analgesics do not eliminate the cause of pain but reduce or eliminate that feeling. Non-steroid analgesics are preferred in mild and moderate, and opioids are used to moderate or severe pain that does not respond to anti-inflammatory agents. However, nurses avoid the administration of opioids because of side effects and addiction risk.The first step in the effectiveness of pain management in the emergency department is evaluation and control. Pain control should be included in the emergency management system from the stage of triage assessment of the patient and should be concluded with the correct analgesic use, if necessary. In emergency departments, waiting for analgesia can be prolonged unnecessarily, and mostly insufficient doses of analgesics administered.Mainly the use of opioids in the emergency department is not preferred much because it reduces the symptoms and masks the examination findings. However, against this conventional idea, recent studies have shown that opioids use reduces pain-related anxiety.Also, it increases the patients' participation in the examination, thus making it more effective. While patients feel better, symptoms such as tenderness and defense were generally not affected by analgesia.This descriptive study was conducted to evaluate the attitude and knowledge of nurses working in a university hospital about opioid analgesic administration, after the ethical committee approved.
PROBLEM TO BE SOLVED: To obtain a composition for a lip stick having smooth feeling in use and only a little of the secondary adhesivity by compounding a volatile oil component, a water-repelling polymer, powder and a non-volatile oil component. SOLUTION: This composition contains 10-50wt.% volatile oil component (e.g. a silicone oil), 10-35wt.% water-repelling polymer (e.g. a silicone resin) soluble in the volatile oil component, 1-25wt.% powder (e.g. silica) and 10-40wt.% non-volatile oil component (e.g. a liquid paraffin) compatible with the volatile oil component. The powder having a larger specific surface area is preferable because it can absorb the excess of the water-repelling polymer and the non- volatile oil component, and it is compounded in such a manner that the total surface area of the powder in 1g of the composition is 1-25m<2> . The compounding ratio of the water-repelling polymer to the non-volatile oil component is 2/1 to 1/2.
Participants were administered sebelipase alfa once weekly (qw) as an intravenous (IV) infusion at the same dose received in Study LAL-CL01 (0.35, 1, or 3 milligrams per kilogram \[mg/kg\]) for 4 weeks. After the initial 4 qw doses, participants transitioned to dosing every other week (qow) at either 1 mg/kg (participants who initiated treatment at 0.35 or 1 mg/kg qw) or 3 mg/kg (participants who initiated dosing at 3 mg/kg qw). Subsequent modifications to the dose and dosing frequency were permitted for individual participants based on observed safety, tolerability, and clinical response to treatment. Participants could continue to receive treatment with sebelipase alfa for up to 5 years.
INTRODUCTION: Body mass composition is directly related to health and its disorders are correlated with diseases such as obesity, diabetes, osteoporosis and sarcopenia. The purpose of this study was to analyze body mass composition among traditional elementary school students and ballet school students.
METHODS: A total of 340 students participated in the study, 95 of whom attended ballet school and 245 elementary school students. A Tanita BC-418 MA analyzer was used to analyze body mass composition. Such body composition indices as BMI (Body Mass Index), muscle mass, fat mass, lean body mass and water content were evaluated.
RESULTS: The results show statistical significance for BMI between high school ballet students and elementary school ballet students, as well between high school ballet students and elementary school students. Comparisons in relation to gender and schools BMI, statistical significance was obtained for: BHSw (ballet high school women) and EBSw (elementary ballet school women), BHSw and ESw (elementary school women), BHSm (ballet high school men) and EBSm (elementary ballet school men), and between BHSm and ESw. Comparing muscle mass index (kg) between ballet high school and elementary school, between ballet high school and elementary school, and between ballet high school and elementary school - statistical significance was obtained for all comparisons. Analyzing in pairwise comparisons by gender and school achieved a statistically significant difference for: BHSw and EBSw, BHSm and EBSw, EBSw and ESm. Comparing the fat mass index (kg), no significant differences were observed between the analyzed schools and the school and gender of the children studied. The value of the lean body mass index differed significantly between groups by school and gender. Comparing the water content index, statistically significant differences were obtained for school and gender.
DISCUSSION: The body mass composition of ballet school students differs from that of standard school students.
Stromal derived factor 1 (SDF1) has been shown to be involved in the pathogenesis of pulmonary artery hypertension (PAH). However, the detailed molecular mechanisms remain unclear. To address this, we utilized primary cultured rat pulmonary artery smooth muscle cells (PASMCs) and monocrotaline (MCT)-induced PAH rat models to investigate the mechanisms of SDF1 driving PASMCs proliferation and pulmonary arterial remodeling. SDF1 increased runt-related transcription factor 2 (Runx2) acetylation by Calmodulin (CaM)-dependent protein kinase II (CaMKII)-dependent HDAC4 cytoplasmic translocation, elevation of Runx2 acetylation conferred its resistance to proteasome-mediated degradation. The accumulation of Runx2 further upregulated osteopontin (OPN) expression, finally leading to PASMCs proliferation. Blocking SDF1, suppression of CaMKII, inhibition the nuclear export of HDAC4 or silencing Runx2 attenuated pulmonary arterial remodeling and prevented PAH development in MCT-induced PAH rat models. Our study provides novel sights for SDF1 induction of PASMCs proliferation and suggests that targeting SDF1/CaMKII/HDAC4/Runx2 axis has potential value in the management of PAH.