anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Obesity is a chronic disease consisting of the increase in body fat stores. Obesity is an important health concern because of its well known relationships with metabolic and endocrine disorders such as cardiovascular disease, type 2 diabetes, hypertension and immune dysfunction. Low-grade systemic inflammation, confirmed by the increase of inflammatory markers such as C-reactive protein and interleukin-6 has been observed in obesity. CD4+ T-helpers are the most important regulators of immune system. Epidemiological evidence has linked obesity to several (but not all) autoimmune disorders, including inflammatory bowel disease (IBD) and psoriasis .Some sublineages of T- helpers plays core roles in immune dysfunction, and recent evidence demonstrates that an imbalance of T-cell subgroups including Th1, Th2, Th17 and Treg has occurred in obesity. This imbalance is the redirection of the immune response from most often Th2 and Treg like responses to Th1 and Th17 like responses respectively, however the opposite is desired. Vitamin A (VA) or VA-like analogs known as retinoids, are potent hormonal modifiers of type 1 or type 2 responses but a definitive description of their mechanism(s) of action is lacking. High level dietary vitamin A enhances Th2 cytokine production and IgA responses, and is likely to decrease Th1 cytokine production. Retinoic acid inhibits IL-12 production in activated macrophages, and RA pretreatment of macrophages reduces IFNγ and TNF α production and increases IL4 production in antigen primed CD4 T cells. Supplemental treatment with vitamin A or retinoic acid (RA) decreases IFNγ and increases IL5, IL10, and IL4 production.
FIELD: veterinary. SUBSTANCE: preparation has glucose, sodium chloride, calcium lactate or acetate, ascorbic acid, ethacrydine lactate and furacillin. Additionally, the preparation has ε-aminocaproic acid lactam. Preparation is used as a mixture of dry powder-like granulated or tabletted substances indicated above of the definite composition that are packaged selectively into three packets. Packet content is dissolved in water at 65 C, not above, stirred and kept up to the complete dissolving. Prepared solution is drunk to calves, possibly, with colostrum addition. EFFECT: increased effectiveness of preparation.
In this group, besides the instructions described in the control group, volunteers will receive irradiation with AsGaAl laser, wavelength of 780 nm (Laser XT Therapy, DMC, São Carlos, SP) with fixed power of 100mW, energy density of 35 J/cm2 (considering a spot size of 0.028 cm2 of this equipment), the dose will be 1 J per point. The irradiation will be performed at a cervical, an apical point and another point exactly on the injury, totaling a dose of 3J. Treatment should be performed in 3 sessions with an ideal 72-hour interval between them.
The instant disclosure provides a surgical instruments collaborative management system and method. The system at least includes an automatic identification module and a notification module. The automatic identification module at least includes a robotic arm and an identification device which is for identifying the surgical instruments contained in a container to output an identification information. The notification module at least includes a receiving unit, a processing unit and a notification unit. The receiving unit is for receiving the identification information from the automatic identification module, the processing unit is for producing at least one of a conformity information and an alerting information according to the identification information, and the notification unit is for receiving at least one of the qualified information and the alerting information from the processing unit and outputting a notification information to a user according to at least one of the qualified information and the alerting information. The system provided by the instant disclosure may effectively perform the management of the surgical instrument through a semi- collaborative manner.
Participants will complete a 4-week pre-treatment period to collect baseline movement data with a wearable device, then receive SC RO7204239 every 4 weeks for 52 weeks. After the treatment period, participants will have the option to receive RO7204239 for an additional 52 weeks.
Leuprorelin Acetate Injection Kit 11.25 mg, every 12 weeks subcutaneously, for up to at most 8 years. Participants received interventions as part of routine medical care.
Preoperative administration of a standard high-calorie-high-protein liquid oral nutritional supplement \[Meritene® Protein Drink (200 mL per serving); Nestlé Health Science - Creully Sur Seulles - France\]. Two units of Meritene® Protein Drink per day will be administered for 7 days before surgery.
Systems and methods to improve the optical character recognition of records, and in particular health records, are provided. An image of a medical record is received, and an initial optical image recognition (OCR) on the image is performed to identify text information. The OCR signal quality may be measured, and areas of insufficient OCR signal quality may be isolated. The signal quality is determined by a weighted average of semantic analysis of the resulting text, and/or OCR accuracy measures. The OCR process may be repeated on the isolated regions of lower signal quality, each time using a different OCR transform, until all regions are completed with a desired degree of signal quality (accuracy). All the regions of the document may then be recompiled into a single document for outputting.
Vaccine comprising a conjugate of compatible immunogenic carrier and a prepn. of human chorionic gonadotrophin beta, the prepn. not having gps. which would react strongly with anti-LH serum. The vaccine is specif. a conjugate of tetanus anatoxin and human chorionic gonadotrophin beta which has been purified immunochemically by reaction with polymerised heterologous anti-LH sera before conjugation to eliminate the gps. capable of reacting strongly with anti-LH sera. The vaccine is used as a contraceptive for women which has a minimum of side-reactions with other endogenous hormones which can be admin. by medical auxiliaries and which only requires a periodic complementary treatment.
CMI is extensively biotransformed to DMI and other metabolites and their glucuronide conjugates. DMI is pharmacologically active, but its effects on OCD behaviors are unknown. These metabolites are excreted in urine and feces, following biliary elimination. After a 25 mg radiolabeled dose of CMI in excreted in urine and feces, following biliary elimination. After a 25 mg radiolabeled dose of CMI in two subjects, 60% and 51%, respectively, of the dose were recovered in the urine and 32% and 24%, respectively, in feces. In the same study, the combined urinary recoveries of CMI and DMI were only about 0.8% to 1.3% of the dose administered. CMI does not induce drug- metabolizing enzymes, as measured by antipyrine half-life.
The invention discloses application of circular RNA HUWE1(circ-HUWE1) as a novel potential diagnosis biomarker and therapeutic target of gastric cancer and colorectal cancer. The circ-HUWE1(hsa _ circ _0140388| chrX: 53641494-53644407- | HUWE1) is formed by reverse splicing of exon 20-23 of HUWE1 gene, and the cyclization sequence has 589 bases. The invention prepares the qRT-PCR primer of circ-HUWE1 and small interfering RNA (siRNA) for interfering circ-HUWE1 in vitro. As compared to normal controls, circ-HUWE1 was significantly up-regulated in tumor and plasma samples from both gastric and colorectal cancer patients. In vitro experiments show that circ-HUWE1 plays a role of a oncogene in gastric cancer and colorectal cancer cells. The research result of the invention shows that circ-HUWE1 is a new potential biomarker and therapeutic target for diagnosing gastric cancer and colorectal cancer.
Brivaracetam used as adjunctive treatment, flexible dosing up to 200 mg /day in b.i.d (twice daily) administration. Dose increase or decrease can be made in increments of maximum 50 mg/day on a weekly basis.
Adenosine causes cardiac vasodilation which increases cardiac blood flow. Adenosine is thought to exert its pharmacological effects through activation of purine receptors (cell-surface A1 and A2 adenosine receptors). Although the exact mechanism by which adenosine receptor activation relaxes vascular smooth muscle is not known, there is evidence to support both inhibition of the slow inward calcium current reducing calcium uptake, and activation of adenylate cyclase through A2 receptors in smooth muscle cells. Adenosine may also lessen vascular tone by modulating sympathetic neurotransmission. The intracellular uptake of adenosine is mediated by a specific transmembrane nucleoside transport system. Once inside the cell, adenosine is rapidly phosphorylated by adenosine kinase to adenosine monophosphate, or deaminated by adenosine deaminase to inosine. These intracellular metabolites of adenosine are not vasoactive. 

Myocardial uptake of thallium-201 is directly proportional to coronary blood flow. Since adenosine injection significantly increases blood flow in normal coronary arteries with little or no increase in stenotic arteries, adenosine injection causes relatively less thallium-201 uptake in vascular territories supplied by stenotic coronary arteries i.e., a greater difference is seen after adenosine injection between areas served by normal and areas served by stenotic vessels than is seen prior to adenosine injection.
This randomized-controlled pilot study will examine the implementation of a cardiovascular health intervention on pregnant and postpartum mothers. The investigators will adapt a cardiovascular health intervention into an evidence-based home visiting program, Family Check-Up to create Family Check-Up Heart. Through a Type 1 hybrid effectiveness implementation design, the pilot study will test the feasibility and effectiveness of Family Check-Up Heart (Family Check-Up Heart, n=100; Family Check-Up, n=50). The investigators hypothesize that Family Check-Up Heart will show comparable levels of engagement and acceptability as Family Check-Up alone, and mothers receiving Family Check-Up Heart will have greater improvements in cardiovascular health at 6 months postpartum compared to Family Check-Up alone.

A second goal of the hybrid study is to understand the reach, engagement, and context for implementation of Family Check-Up Heart and gather information for development of the multi-center home visiting model trial. The Family Check-Up Heart program is intended to improve the cardiovascular health of low-income mothers compared to the traditional Family Check-Up and other home visiting programs by incorporating individualized, culturally competent interventions that target diet and exercise, blood pressure control, stress management and self-care, and smoking cessation. The intervention includes cardiovascular assessment and feedback, followed by a tailored treatment program delivered by family coaches in 3-4 week modules to establish goals and track progress. These sessions will work towards obtaining positive cardiovascular health outcomes and empowering mothers of infants to achieve their goals through education and a connection to resources which the investigators hypothesize will also preserve child cardiovascular health. Primary analyses will assess the impact of Family Check-Up Heart on maternal cardiovascular health outcomes when the child is 6 months old compared to Family Check-Up alone.
The present invention provides an osmotic device containing controlled release diltiazem in the core in combination with a rapid release ACE inhibitor, or diuretic, in an external coat. The delivery device of the invention can also be a chronotherapeutic osmotic device that provides a delayed and controlled release of diltiazem and a delay and rapid release of an ACE inhibitor or diuretic. A wide range of ACE inhibitors or diuretics can be used in this device. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One specific embodiment of the osmotic device includes an external coat that has been spray coated rather than compression coated onto the device. The device with spray coated external core is smaller and easier to swallow than the similar device having a compression coated external coat. The device is useful for the treatment of blood pressure or hypertension related disorders.
FIELD: medicine, pharmacy. SUBSTANCE: water-soluble silver-containing bactericidal composition has highly-dispersed metallic silver and poly-N-vinylpyrrolidone. Composition is prepared by interaction of 2-5% ethyl alcohol an aqueous solution with silver nitrate an aqueous solution in the presence of poly-N-vinylpyrrolidone at 65-75 C in dark in inert atmosphere. The end product is highly-dispersed metallic silver stabilized by polymer. Then 0.05-10.0% an aqueous solution of hydrogen peroxide is added to an aqueous solution of silver dispersion at metal content 0.01-1.0 wt.-% and reaction is carried out up to complete bleaching a reaction mass. Composition is isolated after drying. Composition is colorless and exhibits high aggregate stability and high antibacterial activity. Composition is used to enhance an effectiveness of therapy in treatment of suppurative-septic wound complications and burns. EFFECT: improved method of preparing, enhanced effectiveness of a composition. 2 cl, 1 tbl, 2 ex
The COVID-19 pandemic highlighted the need for potent community-based tools to improve preparedness. We developed a community health-safety climate (HSC) measure to assess readiness to adopt health behaviors during a pandemic. We conducted a mixed-methods study incorporating qualitative methods (e.g., focus groups) to generate items for the measure and quantitative data from a February 2021 national survey to test reliability, multilevel construct, and predictive and nomologic validities. The 20-item HSC measure is unidimensional (Cronbach α = 0.87). All communities had strong health-safety climates but with significant differences between communities (F = 10.65; p<0.001), and HSC levels predicted readiness to adopt health-safety behaviors. HSC strength moderated relationships between HSC level and behavioral indicators; higher climate homogeneity demonstrated stronger correlations. The HSC measure can predict community readiness to adopt health-safety behaviors in communities to inform interventions before diseases spread, providing a valuable tool for public health authorities and policymakers during a pandemic.
The safety and efficacy of JWATM214 will be evaluated in a 'BOIN'-designed dose escalation approach. 3 CAR-T dose levels will be tested in this study: 1×10\^8, 3×10\^8, and 10×10\^8, whereas the dosage 0.5×10\^8 and 30×10\^8 CAR-T cells will be selected as optional back-up doses for potential escalation or de-escalation.
Hemodialysis patients with end stage renal disease have a high mortality rate. In individual patients, mortality is associated with a low serum albumin concentration, a marker of poor nutritional status, and with elevated C-reactive protein, a marker of inflammation. Since efforts to improve nutrition through dietary intake have not been successful, inflammation is thought to play a key role in determining nutritional status. Recently, it has been shown that malnutrition, inflammation, and atherosclerosis are closely related in patients with chronic renal failure. It is our hypothesis that suppression of the cycle of inflammation, malnutrition, and vascular injury caused by atherosclerosis will improve survival in dialysis patients. This study is designed to examine whether suppression of the inflammatory response can be accomplished safely with Etanercept and to determine if this suppression will improve nutritional status and clinical outcome in hemodialysis patients with poor nutritional status and evidence of inflammation.
The Complementary and Alternative Medicine (CAM), according to the World Health Organization, encompasses knowledge, skills, and practices based on the beliefs and experiences of different cultures for the prevention, diagnosis, treatment, and preservation of health for physical and mental ailments. Reasons for the use of CAM today include its perceived assistance in chronic, psychiatric, and end-stage diseases where conventional medicine may not provide a complete solution, patients' desire for control over their treatments, cultural compatibility and accessibility, and the simplicity of procedures, often with minimal or no invasiveness.The aim of this project is to determine the impact of HBM-based education provided to nursing students on their knowledge, attitude, and health beliefs related to CAM and medication use through a randomized controlled study. It is planned to be conducted between January 2024 and December 2024. The project will involve a total of 120 students in intervention and control groups. Data collection instruments will include a pre-test Personal Information Form, CAM Knowledge and Attitude Scale, Medication Beliefs Scale, and post-test CAM Knowledge and Attitude Scale, Medication Beliefs Scale after six weeks of education.Through this project, the importance of CAM practices for healthcare professionals, especially nursing candidates, will be emphasized. The study will explore various application areas of CAM based on cultural and belief contexts by examining commonly used CAM methods for disease treatment and health preservation. This study will serve as an important resource for assessing the knowledge and attitudes of healthcare professionals, particularly nursing candidates, regarding CAM, understanding the use of complementary practices in healthcare, and raising awareness among healthcare professionals.The popularity of CAM practices, patients' interest in complementary treatments, and the role of these treatments in healthcare underscore the importance of including CAM education in nursing curricula. Additionally, the research will demonstrate how CAM can be evaluated using the Health Belief Model (HBM) and how nursing candidates' knowledge, attitudes, and beliefs toward such practices are shaped. The results of the study may contribute significantly to evaluating the effectiveness of educational programs designed to increase nursing candidates' knowledge levels and influence their attitudes toward CAM.
Czech dysplasia is an autosomal dominant type 2 collagenopathy that is caused by heterozygosity for the recurrent p.(Arg275Cys) COL2A1 variant. Affected individuals usually present with skeletal abnormalities such as metatarsal hypoplasia of the third and fourth toes and early-onset arthropathy, as well as hearing loss. To date, no ophthalmic findings have been reported in patients with Czech dysplasia even though COL2A1 has been implicated in other ocular conditions such as type 1 Stickler syndrome. For the first time, we report the ocular findings in four families with Czech dysplasia, including type 1 vitreous anomaly, hypoplastic vitreous, retinal tears, and significant refractive error. These novel ocular findings expand the phenotype associated with Czech dysplasia and may aid clinicians as an additional diagnostic feature. Patients with congenital abnormalities of vitreous gel architecture have an increased risk of retinal detachment, and as such, patients may benefit from prophylaxis. Considering that many of the patients did not report any ocular symptoms, vitreous phenotyping is of key importance in identifying the need for counseling with regard to prophylaxis.
Mometasone furoate monohydrate. 4 spray doses à 50 micrograms by mouth to be swallowed 4 times daily after meals (9) with no eating or drinking allowed 30 minutes after intake. Duration of treatment is 8 weeks.
An eyesight improving device comprising a solution in a bottle, with a treatment and a wash. The present invention relates to a device for improving the eyesight and cleaning the eye, comprising a solution in the form of drops and an additional composition for eye wash. However, the drops come in a bottle which cleans the impurities. The additional composition is an eyewash which is presented in an eye bath. Eye-related problems often appear from the age of 45 years, without age being the main reason for these problems. I am 56 years old and I have recovered my eyesight thanks to this scientific experiment which was conclusive at the end of six weeks.
This is a randomized, open-label study. The target population is patients ≥ 7 years to 26 years at time of consent who are planning to undergo myeloablative conditioning regimens in preparation HSCT. The study will be conducted at Levine Children's Hospital, Levine Children's Cancer and Blood Disorders Clinic and Atrium Health. Subjects will be screened and consented within 28 days prior to admission. The planned treatment period for Arm A (standard of care with the addition of VCO mouth rinses) or Arm B (standard of care) will begin at the start of subject's admission for conditioning, followed by transplant event with day of transplant defined as Day 0 and continue through Day +45 following transplant or hospital discharge, whichever comes first. A Safety Follow Up Visit will occur no sooner than 30 days from last study drug treatment
Balance disorders are the most common cause of dizziness in children with a prevalence of 0.7 to 15%. Vestibular migraine, benign paroxysmal positional vertigo of the child, post-concussion dizziness as a result of cranial trauma, and viral vestibular neuritis are the most common causes. However, these disorders are often undiagnosed in children as many doctors may attribute these symptoms to behavioural disorders or clumsiness. This is probably because of the difficulty children may have in expressing or describing their dizziness symptoms without specific questioning, but also because of the tendency of children to accept the terminology that an adult offers them or even tend to cling to their parents when they experience a balance disorder or vertigo. Vestibular disorders can also have secondary psychological symptoms with an impact on school learning and quality of life. A precise interrogation to check the symptoms, to look for the triggers and to trace the installation of the symptoms is fundamental to diagnose and make a therapeutic decision. Thus, it is very important to help the child express his or her feelings by proposing different descriptions and formulations to determine the etiology and diagnosis. While a number of international questionnaires validated and translated into French exist in the adult to assess the presence, severity and impact of vestibular symptoms, there is currently no score in French for evaluating disorders of the child's balance. Only one questionnaire was validated in the child in English in 2016, the " Pediatric Vestibular Symptom Questionnaire ". The objective of the research is to validate the French translation of this questionnaire.
In this group deflation was initiated after 2 hours of TR band application as described by Cohen and Alfonso. \[6\] 5 ml of air was deflated at first attempt. Next attempt was carried out after 15 minutes in which further 5 ml was removed. After 15 minutes, the remaining 2 ml of air was released from the band. In case of bleeding or hematoma at any attempt, 6 ml air was re-injected and interval for 15 minutes taken to attempt further air deflation. All the attempts and its response were recorded in the proforma filled out by the assessor.
The target population includes patients in ICUs at the Nîmes and Montpellier University hospitals. This is a population of non-neutropenic patients (polynuclear neutrophils \> 500/mm3) at risk of developing invasive candidiasis.
Patients in the control group will receive a 30-minute supportive listening session by a palliative care physician who has no experience in mindfulness practice. The session involves interviewing patients with the same open-ended questions on suffering experiences. The practitioner will acknowledge the distress of patients when it is appropriate. Outcomes will be measured at baseline and at minute 30.