anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: The objective was to establish a machine learning-based model for predicting the occurrence and mortality of nonpulmonary sepsis-associated ARDS.
METHODS: 80% of sepsis patients selected randomly from the MIMIC-IV database, without prior pulmonary conditions and with nonpulmonary infection sites, were used to construct prediction models through machine learning techniques (including K-nearest neighbour, extreme gradient boosting, support vector machine, deep neural network, and decision tree methods). The remaining 20% of patients were utilized to validate the model's accuracy. Additionally, local data were employed for further model validation.
RESULTS: A total of 11,409 patients were included, with the most common type of infection being bloodstream infection. A total of 7,632 (66.9%) patients developed nonpulmonary sepsis-associated ARDS (NPS-ARDS). Patients with NPS-ARDS had significantly longer ICU stays (6.2 ± 5.2 days vs. 4.4 ± 3.7 days, p < 0.01) and higher 28-day mortality rates (19.5% vs. 14.9%, p < 0.01). Both internal and external validation demonstrated that the model constructed with the extreme gradient boosting method had high accuracy. In the internal validation, the model predicted NPS-ARDS and mortality in such patients with accuracies of 77.5% and 71.8%, respectively. In the external validation, the model predicted NPS-ARDS and mortality in these patients with accuracies of 78.0% and 81.4%, respectively.
CONCLUSION: The model established via the extreme gradient boosting method can predict the occurrence and mortality of nonpulmonary sepsis-associated ARDS to a certain extent.
Group one: will be asked to follow the exercise program with a small group of peers (2 groups/6 participants each) in a zoom meeting 3 times a week/45 min each (including 5 min before and 10 min after the meeting for free talk-chat between the participants e.g. questions, perceptions, etc.).
Sixty patients randomised into two groups, 30 patients in experimental group (oblique orientation) and 30 patients in control group (transverse orientation). All cannulation took place in the operation room. Patients underwent general anesthesia and placed in supine position. Standard monitoring (electrocardiogram, non-invasive arterial pressure, pulseoxymetry) was carried out during the procedure for all patients. Before preparation of the skin, a pre-procedure ultrasound examination was performed to verify internal jugular vein patency, and its diameter was measured. Once the side had been chosen, the cannulation was performed following a sterile technique. All procedure were performed by Seldinger technique, with 22 Gauge IV catheter attached with 3 ml syringe as introducer needle. The vascular puncture was performed under ultrasound guidance, using a single-person technique. With transverse orientation, the transducer was placed transversally over the neck, and once the vein was visible in the middle of the ultrasound image, the needle was inserted in the plane perpendicular to the long axis of the transducer. With oblique orientation, the operator first obtained a transverse view of the vein and then rotated the transducer to 45 degrees (midway) between transverse and longitudinal view.
Some of the patients with COVID 19 pneumonia still have respiratory symptoms despite being treated. It has been reported that pulmonary rehabilitation programs applied in various models and in a small number to relieve or reduce these symptoms reduce dyspnea, increase exercise capacity and improve quality of life. There is no study reporting the results of a pulmonary rehabilitation program applied to COVID 19 patients in our country. The main purpose of this study is to determine the efficacy of pulmonary rehabilitation applied by telecoach to patients with severe COVID 19 pneumonia or persistent respiratory symptoms. Secondly, it is aimed to present the data of Turkish society to the literature. In accordance with this purpose investigators planed a randomised control clinical study. In our study respiratory exercise training and aerobic exercise training will be given to patients who have been hospitalized in intensive care due to COVID 19 and underwent IMV, who were hospitalized in the service and underwent NIMV or high-flow oxygen inhalation, and whose respiratory symptoms persist after discharge. The patients in the study group will be called by phone once a week and a motivating conversation will be made. No control will be made to the control group. Before and after the training, 6-minute walking test, MRC dyspnea scale, SGRQ quality of life questionnaire and hospital anxiety depression scale will be applied.
Narcolepsy is a serious and debilitating condition involving persistent and excessive sleepiness that affects 1 in 2000 Americans and 3 million people worldwide. Although wake-promoting pharmacotherapy can reduce sleepiness there is no cure and people with narcolepsy experience significantly poor health-related quality of life, particularly in the domains of mental and social health. Therefore, the overarching goal of this research is to test the effectiveness of a mindfulness-based intervention (MBI) for improving health-related quality of life as a complementary practice to standard care for narcolepsy. The purpose of this study is to conduct a feasibility trial to determine the optimal parameters for adapting and delivering MBI to people with narcolepsy. The specific aims are to: 1) Determine the feasibility and acceptability of MBI delivered using videoconferencing for the purpose of improving psychosocial functioning in people with narcolepsy and 2) Determine the feasibility of recruitment and assessment methods for delivering MBI using videoconferencing. The feasibility trial includes 60 adults with narcolepsy who will be randomized to receive either a 4-week (brief), 8-week (standard), or 12-week (extended) MBI. Each MBI will be similar in content, which includes mindfulness practices and group discussions with adaptations for working with narcolepsy symptoms. All MBIs will be delivered in small groups using a live videoconferencing platform to enhance accessibility. If the findings of this project support the feasibility of further testing, the next project would be aimed at enhancing rigor and reproducibility (e.g., designing appropriate control, refining outcome measures and eligibility criteria) in preparation for a large-scale pragmatic trial. The overall significance of this research is to develop a scalable mind-body intervention that addresses a major research gap on improving psychosocial functioning in people with narcolepsy.
The intervention platform is an interactive, web-based self-management program comprised of computer-adaptive tests (CATs) to assess depression, anxiety, and resilience and multimedia-assisted components. Participants will access the system once a week for 6 weeks, complete the symptom monitoring CATs, receive score reports, and watch a system-assigned self-management strategy video (which is selected by the system based on the participant's current level of depression/anxiety symptoms).
The utility model relates to an externally-applied skin paste which belongs to the field of drug treating apparatus technique. Generally, the using of the externally-applied medicine of paste and powder is to daub the medicine directly on the skin surface of human body, which can pollute the clothes, and scrape the medicine easily. The dosage of the medicine which is daubed on the surface of the human body is limited which can only sustain for a short time. Therefore, a constantly daubing of medicine for the patient is required which is inconvenient. The utility model has the technical proposal that a medicine bag 1 is filled with externally applied medicine 2 of paste and powder. Pores 3 are overspread on the left plane of the medicine bag 1. Desensitization adhesive layer 4 is daubed around the left plane of the medicine bag 1. The externally-applied skin paste has the advantages that the structure design is reasonable and practical. The medicine bag which is filled with externally-applied medicine of paste and powder is stuck to the affected part through desensitization adhesive layer. Continuous impartment of medicine can pass through the pore to treat dermatopathy, and the medicine can sustain for a long time. The externally-applied skin paste does not pollute the clothes, or scrape the medicine.
Obese patients (patients whose weight is \>190% of ideal body weight) will be receive a single dose of I.V. acyclovir sodium 5mg/kg dosed by adjusted body weight as part of their routine care.
A glass filler and a method for manufacturing the same. In the glass filler of the present invention, the composition of the glass contains iron oxide, and the content of iron oxide in the composition satisfies 0.005. ltoreq. FeO. ltoreq.0.30 and 0.01. ltoreq. T-Fe in terms of mass% 2 O 3 Less than or equal to 0.80 (wherein, T-Fe 2 O 3 To be converted into Fe 2 O 3 Of iron oxide), with respect to the iron oxide in the composition, Fe 2+ The proportion (mass basis) of Fe in the total iron 2+ /(Fe 2+ +Fe 3+ ) Is 0.15 to 1.00 inclusive. The glass filler of the present invention is a glass filler having a composition containing a coloring component, and is a glass filler having a novel composition which has a high visible light transmittance and a controllable color tone, and which can take a color tone in a different range from that of a conventional glass filler having a low visible light transmittance, for example.
A randomized, prospective, multicenter trial will compare two groups of patients with subfoveal choroidal neovascularization secondary to AMD. One group will receive 0.5 mg. ranibizumab intraocularly initially. This will be repeated monthly for 3 months total and then as needed over the period of one year. The other group will receive Reduced Fluence-PDT (25 Joules) followed by 0.5 mg. of ranibizumab intraocularly on the same day. The second group will receive the combination of ranibizumab and RF-PDT as needed over a period of one year. Re-treatment will be determined by the individual investigator based on visual acuity, retinal thickness as measured by optical coherence tomography (OCT), and fluorescein angiography. Visual acuity and OCT measurements will be performed by masked examiners.
Integrin β6 (ITGB6), a member of the integrin family of proteins, is only present in epithelial tissues and frequently associates with integrin subunit αv to form transmembrane heterodimers named integrin αvβ6. Importantly, ITGB6 determines αvβ6 expression and availability. In addition to being engaged in organ fibrosis, ITGB6 is also directly linked to the emergence of cancer, periodontitis, and several potential genetic diseases. Therefore, it is of great significance to study the molecular-biological mechanism of ITGB6, which could provide novel insights for future clinical diagnosis and therapy. This review introduces the structure, distribution, and biological function of ITGB6. This review also expounds on ITGB6-related diseases, detailing the known biological effects of ITGB6.
The mixing groups gathered in the enclosed space form a complex contact network due to face-to-face interaction, which affects the status and role of different groups in social communication. The intricacies of epidemic spreading in mixing groups are intrinsically complicated. Multiple interactions and transmission add to the difficulties of understanding and forecasting the spread of infectious diseases in mixing groups. Despite the critical relevance of face-to-face interactions in real-world situations, there is a significant lack of comprehensive study addressing the unique issues of mixed groups, particularly those with complex face-to-face interactions. We introduce a novel model employing an agent-based approach to elucidate the nuances of face-to-face interactions within mixing groups. In this paper, we apply a susceptible-infected-susceptible process to mixing groups and integrate a temporal network within a specified time window to distinguish between individual movement patterns and epidemic spreading dynamics. Our findings highlight the significant impact of both the relative size of mixing groups and the groups' mixing patterns on the trajectory of disease spread within the mixing groups. When group sizes differ significantly, high inter-group contact preference limits disease spread. However, if the minority reduces their intra-group preferences while the majority maintains high inter-group contact, disease spread increases. In balanced group sizes, high intra-group contact preferences can limit transmission, but asymmetrically reducing any group's intra-group preference can lead to increased spread.
This study aims to investigate the effects of Basic Body Awareness Therapy (BBAT) on balance, jump performance and sports injury anxiety in American football players. Participants were divided into two groups, Body Awareness Therapy Treatment Group (n=22) and a Control group(n=22), by computer-based randomization. Before starting the study, all participants were given detailed information about the content of the study and filled out a voluntary consent form. All participants in both groups were evaluated under the same conditions and surveys were conducted. The intervention group was given BBAT exercises by a physiotherapist who had received BBTA training 2 days a week for 6 weeks. All participants continued their team training during this period. At the end of the 6 weeks, all participants were given the same conditions and the surveys were repeated.
The active ingredient in carmustine for injection, USP is a nitrosourea with the chemical name 1,3-bis(2-chloroethyl)-1-nitrosourea and a molecular weight of 214.06. The drug product is supplied as sterile lyophilized pale yellow flakes or a congealed mass, and it is highly soluble in alcohol and lipids, and poorly soluble in water. Carmustine for injection, USP is administered by intravenous infusion after reconstitution, as recommended.

The structural formula of carmustine is: 

Carmustine for injection, USP is available in 100-mg single-dose vials of lyophilized material. Sterile diluent for constitution of carmustine for injection, USP is co-packaged with the active drug product for use in constitution of the lyophile. The diluent is supplied in a vial containing 3 mL of Dehydrated Alcohol Injection, USP.
Prostate cancer as a critical global health issue, requires the exploration of a novel therapeutic approach. Noscapine, an opium-derived phthalide isoquinoline alkaloid, has shown promise in cancer treatment thanks to its anti-tumorigenic properties. However, limitations such as low bioavailability and potential side effects have hindered its clinical application. This study introduces nanonoscapine as a novel medication to overcome these challenges, leveraging the advantages of improved drug delivery and efficacy achieved in nanotechnology. We monitored the effects of nanonoscapine on the androgen-sensitive human prostate adenocarcinoma cell line, LNCaP, investigating its impact on GLI1 and BAX genes' expressions, crucial regulators of cell cycle and apoptosis. Our findings, from MTT assays, flow cytometry, and gene expression analyses, have demonstrated that nanonoscapine effectively inhibits prostate cancer cell proliferation by inducing G2/M phase arrest and apoptosis. Furthermore, through bioinformatics and computational analyses, we have revealed the underlying molecular mechanisms, underscoring the therapeutic potential of nanonoscapine in enhancing patient outcomes. This study highlights the significance of nanonoscapine as an alternative or adjunct treatment to conventional chemotherapy, warranting further investigation in clinical settings.
The invention provides a double-strand oligonucleotide-epsilon-polylysine compound with an immune regulation function and a preparation and use method of the double-strand oligonucleotide-epsilon-polylysine compound and also provides immunogen composition with functions of triggering immunoenhancement reaction and changing the immunoreaction type and a preparation and use method of the immunogen composition. The immunogen composition comprises the double-strand oligonucleotide-epsilon-polylysine compound and an antigen. The compound contains a compound formed through composition of double-stranded polynucleotide, a cation epsilon-polylysine and metal cations. The compound has the pharmacological activity of immunoregulation. The preparation process of the compound is simple. The compound has good water solubility and a bio-enzyme degradation resisting function. The immunogen composition can trigger the immunoenhancement reaction and change the immunoreaction type.
<P>PROBLEM TO BE SOLVED: To provide compounds, compositions and methods for modulating the activity of receptors.  <P>SOLUTION: Compounds, compositions and methods for modulating the activity of receptors are provided. In particular, the compounds and compositions are provided for modulating the activity of receptors and for the treatment, prevention or amelioration of one or more symptoms of disease or disorder directly or indirectly related to the activity of the receptors. Besides, there are provided the compounds for use in pharmaceutical compositions and methods for modulating the activity of one or more steroid intranuclear receptors. The compounds have formula (I).  <P>COPYRIGHT: (C)2010,JPO&INPIT
The present invention relates to a method and system for forming a miniature tablet using a predetermined compression force in a rotary tablet press. The predetermined compression force can be in the range of about 50 to about 2,000 Newtons, preferably less than about 500 Newtons. In one embodiment, the predetermined compression force is applied using an adjustable ramp for moving a lower punch upwardly towards a downwardly moving upper punch wherein the miniature tablet is formed in a die receiving the lower punch and the upper punch. The height of the adjustable ramp is accurately controlled to precisely provide the predetermined compression force for forming the miniature tablet. It has also been found that breakage of punch stems formed on the lower punch can be reduced by providing a reinforced portion of the punch stem below the slender portion of the punch stem which enters a bore of the die wherein the miniature tablet is formed. The reinforced portion of the punch stem is received in a counterbore portion of the die. A fill cam is adjusted to raise the position of the lower punch in order to maintain the punch stem in the bore of the die and prevent any material used for forming the miniature tablets from entering the counterbore of the die during filling of the die. A pull down cam is similarly adjusted to maintain the punch stem of the lower punch within the bore of the die. The miniature tablet can be used in place of extruded beads or coated non-pareils to provide drug delivery from a capsule.
OBJECTIVE: To analyze the literature and expose best evidence available regarding the benefit of pelvic examination for women with suspected endometriosis METHODS: the AGREE II and GRADE systems for grading scientific evidence.
RESULTS: Endometriosis is characterized by the heterogeneity in its clinical presentation with many different symptoms reported by patients. In the literature, questioning for each symptom has a high sensitivity, reaching 76-98 %, but lacks specificity (20 - 58 %). The symptom-based approach is limited by its low specificity, the absence of external validation for most of the models developed and the inability to characterize the extent of the disease, which could have major implications in the decision - making process. The latest systematic review and meta-analysis included a total of 30 studies with 4,565 participants, compared the diagnostic performance of several modalities for endometriosis. Physical examination had a pooled sensitivity of 71 % and a specificity of 69 %, with an average diagnostic accuracy of 0.76. Overall, the value of pelvic examination is conferred by its high positive likehood ratio and specificity. Besides its diagnostic value, pelvic examination improves patients' management by allowing the identification of a possible myofascial syndrome as a differential diagnosis. It also increases the quality of the preoperative workup and influences the quality of surgical excision and decreases the time to diagnosis.
CONCLUSION: Despite the lack of studies in the primary care context, pelvic examination (vaginal speculum and digital vaginal examination) increases the diagnostic value for suspected endometriosis in association with questioning for symptoms.
Reconstruction of large scale skin defect is still a challenge for clinical surgeons. The application of skin grafting works as an important choice, however, the strong contracture and poor appearance limit its wide application in scar repair. The stromal vascular fraction (SVF) of adipose tissue is a group of heterogeneous cells including multipotential mesenchymal cells, preadipocytes, endothelial cells, fibroblasts, macrophages and smooth muscle cells. Previous researches have reported that SVF could secrete various angiogenic growth factors in vitro and enhance neovascularisation of ischaemic tissue in vivo. The Adipose-derived Stem cells in the SVF are multipotential stem cells which have the ability to regenerate, while differentiating to become adipose tissue and help to improve the texture of the grafted skin. Besides, SVF is easy to be harvested in large numbers with less donor injury and can be used directly after isolation without in vitro culture, which makes it a good alternative for regenerative medicine.This study is to observe the effect of autologous SVF on improving the texture and contracture of skin grafting.

Patients requiring skin graft of 2 symmetry parts of the body between the age of 3 and 70 years will be enrolled and randomized into two groups, named as the experimental group with SVF transplantation and the control group with no cell transplantation. Patients from the experimental group will have a fat aspiration on the surgery day. The adipose tissue in abdomen or thigh will be digested at 37 °C for 60 min with 0.2% collagenase IV. After filtration and centrifugation, mature adipocytes are separated from the cell pellet. The pellet then is treated with erythrocyte lysis buffer twice to remove red cell fragment. The harvested pellet is SVF. The SVF will be resuspended in saline and transplanted between the grafted skin and the wound with 1 million cells for 1 cm2 area. Skin thickness, texture, contracture and colour will be observed to measure the effect of SVF on skin grafting post treatment.
Candida spp. are members of the human mucosal microbiota that can cause opportunistic diseases ranging from superficial infections to life-threatening invasive candidiasis. In humans, the most common infection caused by Candida spp. is vulvovaginal candidiasis (VVC), which affects >70% of women at least once in their lifetime. Of those women, ∼5%-10% develop recurrent VVC (RVVC). In this review, we summarize our current understanding of the host and fungal factors that contribute to susceptibility to VVC and RVVC. We synthesize key findings that support the notion that disease symptoms are driven by neutrophil-associated dysfunction and immunopathology and describe how antifungal immune mechanisms in the vagina are distinct from other mucosal barrier sites. Finally, we highlight key, unanswered research areas within the field that can help us better understand the immunopathogenesis of this infection and facilitate the development of novel preventive, therapeutic, and/or vaccination strategies to combat these common, poorly understood diseases.