anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: neuromeningeal tuberculosis (NMT) is a significant public health challenge in Morocco because of its acute severity and high mortality rates. This study aims to comprehensively evaluate the epidemiological, clinical, therapeutic, and disease progression characteristics of NMT in the Kenitra province.
METHODS: a retrospective analysis was conducted on the medical records of patients diagnosed with NMT at the Diagnostic Center of Tuberculosis and Respiratory Diseases in Kenitra from 2014 to 2017.
RESULTS: among the 33 identified NMT cases, predominantly males (57.6%) were affected, with an age range of 4-76 years and a median age of 25 years. Extrapulmonary manifestations were prevalent, constituting 78.8% (n=26) of all cases, with meningeal localization in 45.5% (n=15) of confirmed cases. Furthermore, 9.1% (n=3) of cases were associated with unconfirmed cerebral tuberculosis (TB), and 12% (n=4) exhibited miliary TB. Familial transmission and comorbidities were identified as significant factors in disease progression. More than half of the patients received standardized antibacillary treatment during hospitalization, which lasted between 9 and 12 months. Treatment outcomes were generally positive (73%), but a 12% case fatality rate and 15% loss to follow-up were observed.
CONCLUSION: this study highlights the complex clinical and public health challenges posed by NMT in Morocco. It emphasizes the need for improved health strategies that not only increase public awareness but also enhance the accessibility and quality of diagnostic services and treatment options.
This invention is a model of the mammalian immune system, having at least two tiers, and its use in the prevention, screening, testing, treatment and research of a variety of diseases and conditions, all of which produce the enzyme, indoleamine 2,3-dioxygenase (IDO) or inspire the body to produce IDO in reaction to them. Unlike the current model of the immune system that has a single tier in the decision process of whether or not the immune system will act,(Same (Self)/Different (Non-Self), this model takes the process at least a step further. Before any attack can occur, all targets judged Different must be judged at least once more. This decision is Baby or Not a Baby. No attack can occur unless the target is judged Different/Not a Baby. IDO production is the determining factor for this judgment.
Endoscopic submucosal dissection (ESD) is a novel technique for the removal of esophageal lesions or polyps with high-risk features. ESD is minimally invasive and allows the removal of esophageal polyps without resorting to morbid surgery. The process of ESD includes marking the lesions selected for removal, followed by submucosal injection of a lifting agent, then circumferential incisions using a specialized knife followed by submucosal dissection of the entire lesion.

Traditionally, knifes utilizing monopolar current such as dual knife or hybrid knife were the preferred tools for endoscopic submucosal dissection. These knifes allows accurate dissection and excellent hemostasis. However, due to monopolar current generated heat, post coagulation syndrome can be seen in up to 8 to 40 % of patients. Post coagulation syndrome present with pain, fever and leukocytosis and requires supportive treatment with IV fluid and antibiotics. In addition, for large esophageal lesions, stricturing can occur after resection due to significant scar formation induced by large amounts of energy. Almost all patients with 60% of the esophageal circumference removed via monopolar knives, will develop an esophageal stricture at some point. These patients require serial esophageal dilations, and although easily managed, its development can be quite troublesome to the patient. Nevertheless, ESD is still the preferred modality for removal of these lesions, since it avoids the need for morbid surgery. Recently, a novel bipolar RFA knife were approved by FDA for the performance of ESD. The knife utilizes bipolar RFA current for submucosal dissection which can potentially expedite submucosal dissection and decrease the rates of post polypectomy syndrome and scar formation, by using significantly less energy. This bipolar knife may allow for removal of large esophageal lesions without causing major esophageal stricturing.

Our tertiary referral center Baylor St Luke's Medical Center is a center of excellence for ESD procedure and the investigators have previously reported our Esophageal ESD experience using the monopolar current knife. The goal of our protocol is to compare the performance of monopolar current cutting knife and bipolar RFA knife in esophageal endoscopic submucosal dissection.
The common premise of synthetic implants in the restoration of diseased tissues and organs is to use inert and solid materials. Here, a porous titanium implant enables the delivery of microencapsulated bioactive cues. Control-released TGFβ1 promoted the proliferation and migration of human mesenchymal stem cells into porous implants in vitro. Upon 4-wk implantation in the rabbit humerus, control-released TGFβ1 from porous implants significantly increased BIC by 96% and bone ingrowth by 50% over placebos. Control-released 100 ng TGFβ1 induced equivalent BIC and bone ingrowth to adsorbed 1 μg TGFβ1, suggesting that controlled release is effective at 10-fold less drug dose than adsorption. Histomorphometry, SEM and μT showed that control-released TGFβ1 enhanced bone ingrowth in the implant's pores and surface. These findings suggest that solid prostheses can be transformed into porous implants to serve as drug delivery carriers, from which control-released bioactive cues augment host tissue integration.
A stroke occurs when blood cannot reach part of the brain, either because of a blocked blood vessel (ischemic stroke) or because of a burst blood vessel (hemorrhagic stroke). When a part of the brain is deprived of blood, brain cells in that part often die or are at risk of dying. In addition to physical difficulties, older adults who survive strokes can also suffer from depression and cognitive dysfunction. Effective psychotherapy treatments that provide rehabilitation for problems in emotions and thinking are still needed. Ecosystem focused therapy (EFT) is a specialized psychotherapy that helps patients learn problem-solving skills and make adjustments in their environment. This study will determine the effectiveness of EFT in reducing depression and improving functioning and quality of life in older adults who experienced an ischemic stroke and are now depressed.

Participation in this study will last 1 year. Participants will be randomly assigned to receive one of two treatments: EFT or education in stroke and depression (ESD). Both treatments will be led by therapists and will involve 12 sessions over 25 weeks, with sessions occurring weekly for the first month, every other week for the second 2 months, and monthly for the last 3 months. EFT will involve the following: teaching the participant skills for solving problems related to adjusting to a stroke, altering the participant's physical environment to accommodate new needs, and helping the family or caregiver to assist in the participant's adaptation. ESD will involve providing the participant with education on living with a stroke and depression. Study assessments will include interviews and will occur at nine time points: at baseline and after 2, 3, 6, 10, 14, 20, 26, and 52 weeks. These assessments will measure participants' mood, thinking, and functioning. A family member or caregiver of the older adult participant must also be able to participate in the study, in order both to complete assessments and effectively implement EFT.
You will be given an antibiotic (Ciproflaxin) to take twice a day beginning the day before the procedure, and continuing for a total of 3 - 5 days. You will also be given 4 pills called (Valtrex) valacyclovir to take three times a day for 14 days, beginning the day before the procedure. You will be given a pill diary in which you will record each dose of valacyclovir that you take. You will receive brachytherapy (radioactive seed placement) the day after you begin taking your pills. After the radioactive seeds are placed, while you are still in the operating room, you will receive an injection into your prostate of 1 or 2 ml (one-fifth or two-fifths of a teaspoon) of a solution of the vector carrying the gene.
The invention relates to a medicine for diminishing inflammation in bilis and appendix. Its main materials and weight ration are as follows: lysimachia 60-150, oriental wormwood 30-60, bupleurum 20-30, giant knotweed, green bristlegrass mint, dried oil orange peel, etc. each 20-40, herb of diverse wormwood, rhubarb etc. each 15-20, gentian, mint etc. 20-30. the inventino provides functions of removing heat from the liver benefiting gallbladder, clearing the hollow viscera, and promoting blood circulation etc. it also possesses functions of lowering blood fat, anti blood agglomeration, expanding coronary artery and improving microcirculation.
<P>PROBLEM TO BE SOLVED: To provide a xanthone derivative having weak side effects and exhibiting excellent collagen-producing activity, and to provide a method for producing the xanthone derivative.  <P>SOLUTION: The xanthone derivative having weak side effects and exhibiting excellent collagen-producing activity has -10 mV to -700 mV oxidation-reduction potential. The derivative has a tripeptide consisting of cysteine, alanine and cysteine bonded to a hydroxy group of the xanthone by an ester bond. The cysteine, the alanine and the cysteine are peptide-bonded. The method for producing the derivative includes steps of adding soybean powder and Bacillus natto to a pericarp powder of mangosteen or a Salacia powder, fermenting the resultant mixture, filtering the fermented liquid, and reducing the resultant filtrate using an alkali, the main steps therein being the fermentation step and the alkali reduction step.  <P>COPYRIGHT: (C)2009,JPO&INPIT
PURPOSE:To obtain a composition for skin and hair excellent in usability, having low viscosity and capable of being lightly taken with a finger without threading when taking it in one's hand. CONSTITUTION:The composition for skin and hair consists of at least one of a pair of a polyoxyethylene alkyl ether acetate of the formula (R is 12-18C alkyl or alkenyl; n is 2-20; M is H, Na, K, NH4 or an alkanolammonium ion), e.g. sodium polyoxyethylene (2) lauryl ether acetate, and an inorganic or organic salt, a pair of a compound of the formula and a higher alcohol, preferably a14-22C saturated aliphatic alcohol, or a combination of a compound of the formula, a higher alcohol and a water soluble compound having hydroxyl groups in a molecule (e.g. a polyvalent alcohol). The composition is comprised of 5-40 (wt.) %, preferably 8-30 % compound of the formula, 0.2-2 % higher alcohol and 1-15 % water soluble compound.
Serious neuropsychiatric (NP) events have been reported with use of montelukast sodium. These postmarketing reports have been highly variable and included, but were not limited to, agitation, aggressive behavior or hostility, anxiousness, depression, disorientation, disturbance in attention, dream abnormalities, dysphemia (stuttering), hallucinations, insomnia, irritability, memory impairment, obsessive-compulsive symptoms, restlessness, somnambulism, suicidal thoughts and behavior (including suicide), tic, and tremor. NP events have been reported in adult, adolescent, and pediatric patients with and without a previous history of psychiatric disorder. NP events have been reported mostly during montelukast sodium treatment, but some were reported after montelukast sodium discontinuation. Animal studies showed that montelukast distributes into the brain in rats [see Clinical Pharmacology (12.3)]; however, the mechanisms underlying montelukast sodium-associated NP events are currently not well understood. Based upon the available data, it is difficult to identify risk factors for or quantify the risk of NP events with montelukast sodium use. 

Because of the risk of NP events, the benefits of montelukast sodium may not outweigh the risks in some patients, particularly when the symptoms of disease may be mild and adequately treated with alternative therapies. Reserve use of montelukast sodium for patients with allergic rhinitis who have an inadequate response or intolerance to alternative therapies [see Indications and Usage (1.3)]. In patients with asthma or exercise-induced bronchoconstriction, consider the benefits and risks before prescribing montelukast sodium. 

Discuss the benefits and risks of montelukast sodium use with patients and caregivers when prescribing montelukast sodium. Advise patients and/or caregivers to be alert for changes in behavior or for new NP symptoms when taking montelukast sodium. If changes in behavior are observed, or if new NP symptoms or suicidal thoughts and/or behavior occur, advise patients to discontinue montelukast sodium and contact a healthcare provider immediately. In many cases, symptoms resolved after stopping montelukast sodium therapy; however, in some cases symptoms persisted after discontinuation of montelukast sodium. Therefore, continue to monitor and provide supportive care until symptoms resolve. Re-evaluate the benefits and risks of restarting treatment with montelukast sodium if such events occur.
The application provides essence with suspended microspheres and a preparation method thereof, and belongs to the technical field of skin care products and preparation thereof. The essence has a novel micro-bead suspension appearance, is good in skin-attaching property when in use, is oily, silky and not greasy, and can moisten and soften skin after being absorbed. Under the condition of no emulsifier, the protective effect of the emollient is realized, and the water loss of the skin is effectively reduced. Polyacrylic acid polymers are used for uniformly suspending oil-soluble components such as skin-moistening oil and oil-soluble active matters in a spherical microbead form, and the microbead is moderate in size and hardness. The product is safe and mild and has good stability. The water soluble active substances for moisturizing and resisting aging are absorbed by skin by using polyalcohol such as glycerol as carrier; meanwhile, the skin care product has an oil-soluble active ingredient of batyl alcohol for slowing down photoaging damage, and grease such as squalane is used as a carrier to protect the skin; the product realizes the dual ways of slowing down natural aging and photoaging, and comprehensively repairs and tightens the skin.
The present invention is a natural anthropogenic dietary supplement containing tryptophan in combination with vitamins as well as minerals in order to facilitate treatment of sleep disorders such as but not limited to jet lag disorder and circadian rhythm sleep disorder. The composition of the present invention facilitates increased metabolism of tryptophan. The compositions of the present invention are provided in either gel capsules or as a beverage dose for consumption. The compositions of the present invention include embodiments that incorporate as a part thereof calcium salts and magnesium salts. Vitamins such as but not limited to niacin are further included in embodiments of the composition of the present invention. Furthermore, additional natural ingredients further contribute to the makeup of the embodiments of the composition of the present invention.
OBJECTIVE: To explore the mechanism of spleen tissue inflammatory response induced by altitude hypoxia in mice.
METHODS: C57BL/6 mice were randomly assigned to a plain, i.e., low-altitude, normoxia group and an altitude hypoxia group, with 5 mice in each group. In the plain normoxia group, the mice were kept in a normoxic environment at the altitude of 400 m above sea level (with an oxygen concentration of 19.88%). The mice in the altitude hypoxia group were kept in an environment at the altitude of 4200 m above sea level (with an oxygen concentration of 14.23%) to establish the animal model of altitude hypoxia. On day 30, spleen tissues were collected to determine the splenic index. HE staining was performed to observe the histopathological changes in the spleen tissues of the mice. Real time fluorogenic quantitative PCR (RT-qPCR) and Western blot were conducted to determine the mRNA and protein expressions of interleukin (IL)-6, IL-12, and IL-1β in the spleen tissue of the mice. High-throughput transcriptome sequencing was performed with RNA sequencing (RNA-seq). KEGG enrichment analysis was performed for the differentially expressed genes (DEGs). The DEGs in the key pathways were verified by RT-qPCR.
RESULTS: Compared with the plain normoxia group, the mice exposed to high-altitude hypoxic environment had decreased spleen index (P<0.05) and exhibited such pathological changes as decreased white pulp, enlarged germinal center, blurred edge, and venous congestion. The mRNA and protein expression levels of IL-6, IL-12, and IL-1β in the spleen tissue of mice in the altitude hypoxia group were up-regulated (P<0.05). According to the results of transcriptome sequencing and KEGG pathway enrichment analysis, 4218 DEGs were enriched in 178 enrichment pathways (P<0.05). DEGs were significantly enriched in multiple pathways associated with immunity and inflammation, such as T cell receptor signaling pathway, TNF signaling pathway, and IL-17 signaling pathway (P<0.05) in the spleen of mice exposed to high-altitude hypoxic environment. Among them, IL-17 signaling pathway and the downstream inflammatory factors were highly up-regulated (P<0.05). Compared with the plain normoxia group, the mRNA expression levels of key genes in the IL-17 signaling pathway, including IL-17, IL-17R, and mitogen-activated protein kinase genes (MAPKs), and the downstream inflammatory factors, including matrix metallopeptidase 9 (MMP9), S100 calcium binding protein A8 gene (S100A8), S100 calcium binding protein A9 gene (S100A9), and tumor necrosis factor α (TNF-α), were up-regulated or down-regulated (P<0.05) in the altitude hypoxia group. According to the validation of RT-qPCR results, the mRNA expression levels of DEGs were consistent with the RNA-seq results.
CONCLUSION: Altitude hypoxia can induce inflammatory response in the mouse spleen tissue by activating IL-17 signaling pathway and promoting the release of downstream inflammatory factors.
The invention provides a compound anticancer drug sustained release agent containing bendamustine, which is a sustained release injection consisting of sustained release microspheres and solvent, wherein, the sustained release microspheres comprise effective anticancer components and sustained-release excipient, and the solvent is a special solvent containing a suspending agent. The effective anticancer components are bendamustine and the combination of bendamustine synergist chosen from alkylating agent and/or hormone anticarcinogen. The sustained-release excipient is chosen from one of or the combination of polylactic acid, copolymer thereof, monomethyl polyethylene glycol, polyethylene glycol, carboxyl end polylactide copolymer, dual fatty acid, sebacie acid copolymer, poly (erucic dimer- sebacie acid), poly (fumarate- sebacie acid), Polifeprosan, polylactide copolymer or mixture and EVAc. The suspending agent is chosen from carboxymethyl cellulose, etc., and the viscosity of the suspending agent is 80cp-3000cp (in the temperature of 20 DEG C-30 DEG C). The sustained release microspheres can also be produced into a sustained-release implant. The sustained-release implant and the sustained release injection is arranged around the tumor or injected in the tumor, which can obviously improve the curative effect if being applied independently or combined with chemotherapeutics and/or radiotherapeutics and other non-operative treatment.
PURPOSE: An antibacterial agent containing ginsenoside compound K or derivative thereof is provided to ensure specific antibacterial activity against various bacteria and to prevent or treat diseases caused by infection of antibiotic resistant bacteria. CONSTITUTION: A ginsenoside compound K is denoted by chemical formula 1. A compound K derivative is a fatty acid derivative or halogenide of the compound K. The fatty acid derivative of the compound K is conjugated with saturated or unsaturated fatty acids of 10-20 carbon atoms. The halogenide is denoted by chemical formula 2 or 3. An antibacterial agent has an antibacterial activity against Staphylococcus sp., Bacillis subtilis, Acinetobacter calcoaceticus, Streptococcus pyogenes, Enterococcus faecalis, or Mycobacterium smegmatis. A pharmaceutical composition for preventing or treating diseases caused by bacteria contains the antibacterial agent as an active ingredient. The composition additionally contains a pharmaceutically acceptable carrier. An antibacterial quasi-drug composition contains the antibacterial agent as an active ingredient.
In the electroacupuncture group (EG), participants received acupuncture at 10 scalp points (Baihui \[GV20\], Ex-hn 1, 3 points of intelligence \[Shenting \[GV24\], Benshen \[GB13\] on both sides, Touwei \[ST8\] on both sides). Electroacupuncture was applied for 20 minutes at Benshen \[GB13\] and Touwei \[ST8\] on both sides. They also received acupuncture at Tai chong \[LV3\], Tai Yuan \[LU9\], and Tai Xi \[KI3\] on both sides, as shown in picture 1. Acupuncture sessions were weekly for 10 weeks.
Microencapsulated virginiamycin-type antihotic compsns. for oral admin. comprise 1-30% of >=1 virginiamycin-type antibiotic coated with spermaceti contg. 1-5% of sodium lauryl sulphate. The bitter antibiotics are not liberated from the microcapsules until they reach the stomach so their unpleasant taste is not apparent. Sodium lauryl sulphate itself has no bitter taste, and unlike many similar surfactants is compatible with the antibiotics. Preferred compsns. contain about 15% antibiotic, and 2-4% sodium lauryl sulphate.
Gastric cancer is the fifth most common cause of death worldwide. Early detection and removal of gastric cancer precursors and early gastric cancer is crucial for good outcomes. However, these lesions are subtle and often missed by conventional white light imaging (WLI) endoscopy. Image enhanced endoscopy techniques have been developed to enhance the detection and characterization of gastrointestinal lesions. Narrow band imaging (NBI) is one such technique. Though widely used, its drawbacks include a limited far view as a result of the optical filter causing a dark endoscopic view. Linked color imaging (LCI) is a more recent image enhanced endoscopy technique that acquires images by using both narrow-band wavelength light and white light in an appropriate balance, enhancing slight color differences in the red region of mucosa. It has been proven to improve detection of H pylori gastritis and colorectal neoplasms. Thus far, there has been no study to determine whether the use of LCI will increase the detection rate of gastric cancer precursors and early gastric cancer compared to WLI. This study aims to determine whether LCI can increase the detection rate of gastric cancer precursors and early gastric cancer when compared to white light endoscopy, with the null hypothesis being no difference in detection rates. This study will also examine the use of LCI with magnification to predict histology findings for focal lesions seen on endoscopy, as well as the use of LCI in identifying esophageal lesions (such as Barett's esophagus) and duodenal lesions.