anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to an anti-perspirant product containing transparent or translucent micro-emulsion gels, devoid of alcohol and of the oil-in-water type (O/W), comprising an oil phase and a water phase and containing: one or more polyethoxylated O/W emulsifiers and/or one or more polypropoxylated O/W emulsifiers and/or one or more polyethoxylated and polypropoxylated O/W emulsifiers, optionally in addition containing one or more W/O emulsifiers. Said product has an emulsifier content of less than 20 wt. %, in relation to the total weight of the emulsion, an anti-perspirant content of between 5 and 40 wt. %, in particular of between 7 and 25 wt. %, in relation to the total content of the emulsion. Said product can be obtained by heating a mixture of the main constituents comprising the water phase, oil phase, one or more of the inventive O/W emulsifiers, optionally one or more W/O emulsifiers and optionally additional auxiliary agents, additives and/or active ingredients to a temperature within or above the phase inversion temperature range and then by subsequently cooling said mixture to the ambient temperature. According to said method, the droplets of the discontinuous oil phase are interlinked by one or more cross-linking substances, whose molecules are distinguished by at least one hydrophilic region, which has an extension that is suitable for bridging the distance between the micro-emulsion droplets and by at least one hydrophobic region, which can carry out a hydrophobic interaction with the micro-emulsion droplets. The product is contained in a pump aerosol consisting of a container and an atomiser pump with the following features: a riser tube, a cylindrical chamber, which is subjected to a pressure by depressing a piston, a pump valve, which closes the cylindrical chamber and opens under a pressure of at least 0.7 mPa, two or more turbulence channels radiating towards a nozzle opening, said channels causing the flowing liquid to rotate in relation to the flow axis. The product is used to prevent excessive perspiration and odour secretion of the skin.
This prospective, randomized, double-blind controlled trial involved 88 patients who were scheduled for inguinal hernia surgery followed by a TAP block. Patients were allocated into group B (n= 44) received 20 ml of 0.25% Ropivacaine for TAP block; group BR (n= 44) received 20 ml of 0.25% Ropivacaine containing 300 μg of buprenorphine for TAP Block. The primary outcome of the study was the analgesic and antihyperalgesic effect of buprenorphine compared to the control group. The duration of analgesia, analgesic consumption, postoperative pain scores at rest and sitting up to 48 hrs, and effect on wound hyperalgesia at 24 and 48 hrs were evaluated. Secondary outcomes of the study include incidence of side effects and TAP block-related complications were recorded. Effect of buprenorphine on patients with predicted high pain scores and incidence of persistent postoperative pain were also determined.

A transversus abdominis plane (TAP) block provides analgesia of the anterior and lateral abdominal wall below the umbilicus by blocking the T6-L1 segmental nerves as they lie within the fascial plane between the transversus abdominis and internal oblique muscles: bilateral block for midline abdominal incision. It was first described in 2001 by Rafi as a traditional blind landmark technique using the lumbar triangle of Petit. Local anesthetic is then injected between the internal oblique and transverse abdominis muscles just deep the fascial plane, the plane through which the sensory nerves pass
Carcinogenesis

Carcinogenicity studies have not been conducted with belumosudil.

Mutagenesis

Belumosudil was not genotoxic in an in vitro bacterial mutagenicity (Ames) assay, in vitro chromosome aberration assay in human peripheral blood lymphocytes (HPBL) or an in vivo rat bone marrow micronucleus assay.

Impairment of Fertility

In a combined male and female rat fertility study, belumosudil-treated male animals were mated with untreated females, or untreated males were mated with belumosudil-treated females. Belumosudil was administered orally at doses of 50, 150 or 275 mg/kg/day to male rats 70 days prior to and throughout the mating period, and to female rats 14 days prior to mating and up to Gestation Day 7. At the dose of 275 mg/kg/day, adverse findings in female rats (treated with belumosudil or untreated but mated with treated males) included increased pre- or post-implantation loss and decreased number of viable embryos. Administration of belumosudil to male rats at a dose of 275 mg/kg/day resulted in abnormal sperm findings (reduced motility, reduced count, and increased percentage of abnormal sperm), and testes/epididymis organ changes (reduced weight and degeneration). Fertility was reduced in both treated males or females at the 275 mg/kg/day dose and reached statistical significance in males. Adverse changes in male and female reproductive organs also occurred in general toxicology studies; findings included spermatozoa degeneration at a belumosudil dose of 35 mg/kg/day in dogs and decreased follicular development in ovaries at 275 mg/kg/day in rats. Changes were partially or fully reversed during the recovery period. The exposure (AUC) at the doses of 35 mg/kg/day in dogs, and 275 mg/kg/day in rats is 0.5 times and 8–9 times, respectively, the clinical exposure at the recommended dose of 200 mg daily.
Masked h-ANG variant conjugates useful for protection of cells, particularly neuronal cells from injury and death, particularly from injury and death associated with ROS (reactive oxygen species). Masked h-Ang variant conjugates do not exhibit ribonucleolytic activity until unmasked. Masked h-ANG variant conjugates are activatable by reaction with ROS and exhibit ribonucleolytic activity only after reaction with ROS. Masked h-ANG variant conjugates are useful in the treatment of neurodegenerative diseases and disorders, such as amyotrophic lateral sclerosis. Certain h-ANG variants in which lysine at position 40 is replaced with cysteine are provided at least as starting materials for making masked h-ANG variant conjugates. Certain h-ANG variants in which lysine at position 40 is replaced with thialysine are generated on unmasking of h-ANG variant conjugates and exhibit ribonucleolyitc activity.
Hialuronic ester is prepd. for use as medicine, cosmetics and plastic material.  Carboxylic groups of hialuronic acids are esterified, and the produced hialuronic esters containing aliphatic group, aromatic group, cyclized group and heterocyclized alcohol group are prepd. in their salt forms.  Quaterary ammonium salt of hialuronic acid is reacted with an esterfication agent in organic solvent to give hialuronic ester.  The starting material, hialuronic acid is extracted from cockscomb.
A hair iron having a first arm having a first free end, a first joint end, a first heating element and a first hair heating plate on an interior surface thereof proximate the first free end. The first heating element providing heat to the first hair heating plate. A second arm having a second free end, a second joint end, a second heating element and a second hair heating plate on an interior surface thereof proximate the second free end. The second heating element providing heat to the second hair heating plate. The first and second arms joined at the first and second join ends via a joint member such that the arms can be flexibly opened and closed to bring the first and second hair heating plates into and out of contact. A first removable, heat-resistant hair iron sheath, the first hair iron sheath configured to wrap around the first hair iron arm covering the first hair heating plate. A second removable, heat-resistant hair iron sheath, the second hair iron sheath configured to wrap around the second hair iron arm covering the second hair heating plate.
Subjects in the CG will receive standard care consisting of periodic visitations at the Allergology or Paediatric Pulmonology Unit in their respective hospitals every 4 - 8 weeks according to their physician's criteria. In addition, patients and caregivers in both groups will receive one educational session regarding the correct use of their inhalers.
Septic patients, coupling severe disseminated intravascular coagulation (DIC) and thrombocytopenia, have poor prognoses and higher mortality. The platelet glycoprotein Ibα (GPIbα) is involved in thrombosis, hemostasis, and inflammation response. However, it remains unclear whether the GPIbα cytoplasmic tail regulates sepsis-mediated platelet activation and inflammation, especially in Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) infections. Using a mouse model of S. aureus-induced bacteremia, we found that both 10 amino acids of GPIbα C-terminal sequence deficiency and pharmacologic inhibition of protein kinase C (PKC) alleviated pathogenesis by diminishing platelet activation and aggregate formation. Furthermore, the GPIbα cytoplasmic tail promoted the phagocytosis of platelets by Kupffer cells in vivo. The genetically deficient GPIbα cytoplasmic tail also downregulated inflammatory cytokines and reduced liver damage, ultimately improving the survival rate of the septic mice. Our results illustrate that the platelet GPIbα cytoplasmic domain exacerbates excessive platelet activation and inflammation associated with sepsis through a PKC-dependent pathway. Thus, our findings provide insights for the development of effective therapeutic strategies using PKC inhibitor treatment against bacterial infection.
Breast cancer, globally the most common cancer in women, presents significant challenges in treatment. Breast-conserving surgery (BCS), a less traumatic and painful alternative to radical mastectomy, not only preserves the breast's appearance but also supports postsurgical functional recovery. However, accurately identifying tumors, precisely delineating margins, and thoroughly removing metastases remain complex surgical challenges, exacerbated by the limitations of current imaging techniques, including poor tumor uptake and low signal contrast. Addressing these challenges, our study developed a series of GnRHR-targeted probes (YQGN-n) for fluorescence imaging and surgical navigation of breast cancer through a drug repositioning strategy. Notably, YQGN-7, with its high cellular affinity (Kd of 217.8 nM), demonstrates exceptional selectivity and specificity for breast cancer tumors, surpassing traditional imaging agents like ICG in tumor uptake and pharmacokinetic properties. Furthermore, YQGN-7's effectiveness in surgical navigation, both for primary breast tumors and metastases, highlights its potential as a revolutionary tool in BCS.
Participants randomized to this arm will receive 20 hours of speed of processing training; this training is designed to improve the speed/accuracy in which they identify and locate visual information using five games/exercises from the POSIT Science Speed of Processing Training. Those who receive 20 hours of speed of processing training will be compared to those participants who are randomized only to receive 10 hours speed of processing training; both of these groups will be compared to those randomized to receive only 10 hours of a computer training (Contact Control Group).
Although it is generally accepted that regular exercise provides substantial health benefits to individuals with T2D, the exact exercise prescription in terms of type (AT versus RT versus AT+RT) still remains an important research issue, particularly in regard to week-to-week glucose control as assessed by HbA1C.

There is a need for more adequately powered and well-controlled studies to examine the effects of RT, AT and AT+RT on HbA1C in individuals with T2D. With the incidence of T2D expected to increase dramatically in the coming years, it is essential to have a better understanding of the relative benefits of various exercise interventions. This information can help better formulate exercise recommendations for patients with T2D as well as potentially provide more exercise options, which is important given the small percentage of individuals with TD2 who regularly exercise. The study group was sedentary women and men with T2D, aged 30 to 75 years. We randomly assigned 262 individuals to an aerobic exercise training only group (AT; n=72), a resistance training only group (RT; n=73), a combination of aerobic plus resistance training (AT+RT; n=76), or a standard care group (SC; n=41). The AT individuals participated in 3 or 4 training sessions each week for 9 months progressing to a total energy expenditure of 12 kcal/kg/week (KKW), which is an exercise dose consistent with the current public health recommendations for physical activity for individuals with T2D. The target exercise intensity was 50%-80% of baseline VO2 max. The RT group participated in 3 sessions per week (9 exercises, 2-3 sets each), which focuses on large muscle groups. This RT regimen is based on the studies that most successfully improved HbA1C in individuals with T2D. Individuals in the AT+RT group completed 10 KKW of aerobic training and a reduced resistance-training regimen of 2 sessions per week (9 exercises, 1 set of each). The AT+RT regimen represents the exercise recommendations of the American College of Sports Medicine (ACSM) and the American Diabetes Association (ADA).

Simply stated, we compared the effect of resistance training alone, resistance in combination with aerobic training, and aerobic training alone to standard care on HbA1C, in initially sedentary women and men with T2D. The primary outcome measure was HbA1C, an integrated measure of blood glucose control over the past 8-12 weeks. Other outcomes of interest included resting blood pressure, C-reactive protein (CRP), total body fat, and lean muscle mass as measured by DEXA, cardiorespiratory fitness, muscular strength, and metabolic measures including serum cholesterol and triglycerides.
The present invention relates to a vaginal contraceptive, particularly a diaphragm, containing two or more drugs. According to the invention the contraceptive is impregnated with a mixture of at least two different spermicides in water. Usually one spermicide is a non-ionic detergent of the alkyl phenol ethoxylate type, whereas the other is a biguanide with antiseptic properties. The non-ionic detergent is, preferably, nonoxynol-9 and the biguanide chlorohexidine gluconate. Very good results are obtained when the vaginal contraceptive according to the invention is impregnated with a mixture of spermicides, containing 10-15% vol./vol. of nonoxynol-9, 0.5-1.5% by weight/vol. of chlorohexidine gluconate, the balance being water. Finally, the invention relates to a vaginal contraceptive which is liquid tight packed in the mixture as defined before.
Nutritional markers such as lean body mass and serum albumin are strong predictors of the mortality and morbidity in patients with end-stage renal failure (ESRF) on maintenance hemodialysis (HD). Maintenance HD is considered to contribute to the malnutrition of patients with ESRF, but the exact mechanism has remained unknown. However, we have recently shown that the bioactivity of insulin-like growth factor-I (IGF-I) is reduced by 50% during HD. Furthermore, we showed that the reduction in the bioactivity of IGF-I is directly linked to an up-regulation of IGF-binding protein-1 (IGFBP-1), the only acutely regulated IGFBP, which increased by 6-fold during HD. IGFBP-1 is produced in the liver, primarily under the control of insulin, which promptly inhibits the hepatic production of IGFBP-1. As plasma insulin remains fairly low during a maintenance HD, the increase in IGFBP-1 may be explained by the absence of insulin.

The finding that HD acutely down-regulates the bioactivity of IGF-I by an up-regulation of IGFBP-1 may not only explain the catabolic mechanisms of HD per se, it also opens for a new treatment strategy of ESRF patients undergoing maintenance HD. Thus, on the basis of our previous study we hypothesize that treatment of ERSF patients with high doses of insulin during maintenance HD may counter-act the HD-induced stimulation of IGFBP-1, making it possible to preserve the bioactivity of IGF-I, and thereby abolishing the catabolic impact of HD.
Subjects with microsatellite stable (MSS) colorectal cancer (CRC) with rat sarcoma gene (RAS) wild-type tumor expressing EGFR who received who received 480 milligram (mg) AFM24 weekly on Day 1, Day 8, Day 15, and Day 22 of a 28-day cycle. A dose could be given over two days (split day dosing).
This is a non-interventional study to determine the rate of control of disease activity in moderate to severe inflammatory bowel disease (IBD) participants, with two parts: cross-sectional evaluation (Day 1) with retrospective data collection and a prospective 12-month evaluation for patients with active IBD at cross-sectional evaluation (Day 1).

The study enrolled 407 patients. This multicenter trial was conducted in Brazil. Retrospective data of previous IBD treatments (drug, dose, treatment duration, drug changes), and use of other health resources related with the management of IBD for previous three years will be collected. Prospective data was collected for a period of 12 months in participants with active disease. UC participants, with no or light disease activity at Day 1 did not continue to 12-month follow up. CD participants, with no or light disease activity at Day 1 but with colonoscopy or calprotectin levels (i.e, calprotectin \>200 ug/g) in the previous year suggestive of inadequate control of activity progressed to 12-month follow up.
This study aimed to examine the effect of disaster nursing course on nursing students' disaster literacy and preparedness perceptions. The study was a one-group quasi-experimental study design in a pretest-posttest design. Pre-test was done on September 27, 2021, and the post-test was applied on January 7, 2022. The location of the study is a public university in Izmir which is located in the western part of Türkiye. The population of the study consisted of nursing students (n: 66) studying in the nursing department of the university and enrolled in the elective course "Disaster Nursing". No sample selection was made, and the study was conducted with 62 volunteer students. Individual introduction form (13 questions), Disaster Literacy Scale (61 items), and Perception of Disaster Preparedness in Nurses Scale (20 items) were used as tools for data collection. At the beginning of the study, data collection tools were collected online form. "Disaster nursing" course was conducted for 14 weeks as an intervention. The descriptive statistical methods (number, percentage, mean, standard deviation), paired sample t-test, and Pearson correlation was used data analysis.
Lomustine single agent 110 mg/m² every 6 weeks (cap. 200 mg) (at further progression treatment will be according to investigators discretion).
An exemplary system, method, and computer-accessible medium for detection of structural disorder(s) of patient(s) can be provided which can include, for example, receiving magnetic resonance imaging (MRI) information of the portion(s), generating gadolinium (“Gd”) enhanced map(s) based on the MRI information using a machine learning procedure(s), and detecting the structural disorder(s) of the patient(s) based on a GD contrast of the Gd enhanced map(s). The Gd enhanced map(s) can be a full dosage Gd enhanced map. The machine learning procedure can be a convolutional neural network. The MRI information can include (i) a low-dosage Gd MRI scan(s), or (ii) a Gd-free MRI scan(s). The Gd contrast can be generated in the Gd enhanced map(s) using a T2-weighted MRI image of the portion(s). Structural disorder(s) can include Stroke, tumor, trauma, infection, Multiple sclerosis and/or other inflammatory disease.
Six intravenous infusions of human umbilical cord blood plasma (HUCBP) during a twelve month study period. The amount of HUCBP being infused on each occasion is 50 mL.
PURPOSE:To provide a new antibiotic useful for a medicine esp. for exterminating methicillin-resistant Staphylococcus aureus. CONSTITUTION:The antibiotic consisting of Y-03559J-A substance of formula I or Y-03559J-B substance of formula II, or a salt thereof permissible from the standpoint of pharmacy. This antibiotic can be obtained by culturing in a medium microbes which belong to Micromonospora and have ability to produce this antibiotic to make this antibiotic produced and accumulated in the cultured product followed by collecting the aimed antibiotic. An esp. preferable strain which belongs to Micromonospora is Micromonospora sp. Y-03559J (FERM P-13677). This new antibiotic gives powerful activity on Gram-positive bacteria, esp. Staphylococcus aureus, having excellent antibacterial activity on multiple drug-resistant Staphylococcus aureus such as MRSA among others.
In this issue, the British Society for Haematology presents guidelines for the diagnosis and management of patients with smouldering multiple myeloma (SMM). The authors provide a practical, evidence-based approach to managing these patients. Key questions remain yet unsolved. Commentary on: Hughes et al. Diagnosis and management of smouldering myeloma: A British Society for Haematology Good Practice Paper. Br J Haematol 2024;204:1193-1206.
This observational study aims to gain a deeper understanding of the interactions and influence of microbes on the human body. By comparing the gut microbiota composition of children in different regions, at varying altitudes, and with distinct dietary habits, the study aims to answer two key questions:

What are the characteristics of children's gut microbiota in different regions, at different altitudes, and with different dietary habits? What is the relationship between the development and maturation process of children's gut microbiota in plateau areas and their immunity, metabolism, and growth? Participants will be asked to provide fecal samples for analysis during the study. They may also be asked to answer questionnaires about their lifestyle factors such as diet and physical activity. The comparison group is included, researchers will compare the gut microbiota composition and diversity of children in low-altitude areas with those in plateau areas to assess any differences in their gut microbiota profiles. By comparing these differences, the mechanism of action of children's gut microbiota on immunity, growth and development can be further analyzed. The findings of this study aim to provide a scientific basis for improving children's health in plateau areas.
The invention relates to a prunella vulgaris antihypertensive foot bath powder and a preparation method thereof. Per 35g of the prunella vulgaris antihypertensive foot bath powder is composed of 20g of mixed Chinese herbal powder, and 15g of mixed Chinese herbal residue. Per 20g of the mixed Chinese herbal powder is composed of prunella vulgaris, cassia seed, Semen Pruni, Chinese holly, radix paeoniae rubra, mulberry leaf, cortex moutan, radix angelicae pubescentis, hemp seed and Taxillus sutchuenensis in a ratio of 10:5-8:4-7:4-6:3-5:2-4:2-3:1-3:2-3:1-2. The 15g of the mixed Chinese herbal residue is the herb residue left by processing of the raw materials in the 20g of mixed Chinese herbal powder. The preparation method includes: (1) pretreatment of raw materials; (2) ultrasonic extraction; (3) concentration and drying; and (4) crushing and sterilization. According to the prunella vulgaris antihypertensive foot bath powder and the preparation method thereof provided by the invention, the preparation process is concise and scientific, and the prepared foot bath powder has the advantages of convenient use, obvious curative effect and good antihypertensive effect.