anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
An oral composition exhibiting increased uptake by dental tissue of antibacterial compounds contained therein and eliminating or substantially reducing the discomfort and pain associated with dentinal hypersensitivity. The composition includes an orally acceptable vehicle for such composition, an effective therapeutic amount of an antibacterial compound, a mixture of anionic surfactant and amphoteric surfactant, the mixture having 0.1 wt. % to 2.0 wt. % anionic surfactant and 0.8 wt. % to 2.0 wt. % amphoteric surfactant, and a potassium ion releasable compound.
PROBLEM TO BE SOLVED: To provide an improved treatment of a cancer such as melanoma, glioma of a high grade malignancy, lung cancer and mammary cancer by administrating temozolomide in one or more times per day. SOLUTION: This improved treatment for a cancer comprises administrating temozolomide of the formula (i.e., 3,4-dihydro-3-methyl-4-oxoimidazo-[5,1-d]1,2,3,4- tetrazine-8-carboximide) in one or more times per day. The total dose of 500-1,200mg/m<2> body surface of a patient is administrated during 5 days by dividing the dose. In the case of the total dose of 1,000mg/m<2> , the daily dose becomes 200mg/m<2> . The daily dose is preferably administrated in 2-4 divided doses. The temozolomide is preferably administered again after 28 days from the first dose. The temozolonide can be administered in a smaller amount for a long period. In this case, the daily dose of 75mg/m<2> is preferably continued for 6 weeks. Moreover, regardless of a dosing period or a total amount of dose, a large amount of an oral pill is preferably administered at the first dose.
FIELD: veterinary. SUBSTANCE: blood from cows with acute catarrhal-purulent form of postnatal endometritis is taken off on the 3-10-th day from the onset of clinical disease symptoms. Prepared nonspecific immune serum blood at titer 1:160-1:320 is administrated to animals showing symptoms of acute postnatal catarrhal-purulent inflammation of uterine mucous membrane at the dose 0.1 ml/kg, intramuscularly. Repeated administration is carried out after 8-12 days. For prophylaxis of acute endometritis nonspecific immune serum blood is administrated at the dose 0.1 ml/kg on the first-second days after calving. EFFECT: improved method of cow treatment. 8 tbl
The invention relates to the field of natural disintegrant premix, which can be used for preparing solid dosage forms of oral medicines, vitamins, food supplements and the like. The composition comprises a mixture of luteolin hull, oat fiber, and at least one additional ingredient selected from the group consisting of guar gum, locust bean gum, carrageenan, ergot bean gum, mango pectin, and combinations thereof. Other optional components are apple fiber, wheat fiber, pea fiber, cellulose powder, agave powder and bamboo fiber. The natural disintegrant compositions provide superior disintegration characteristics to the tablet while maintaining good uniformity, flowability and compressibility during the manufacture of the solid oral dosage form. Tablets made using conventional/organic super disintegrant compositions may be labeled "natural". The composition can replace conventional super-disintegrant, such as croscarmellose (croscarmellose) or crospovidone (crospovidone).
PURPOSE: Hierarchical management is advocated in China to effectively manage chronic obstructive pulmonary disease (COPD) patients and reduce the incidence and mortality of acute exacerbation of COPD (AE-COPD). However, primary and community hospitals often have limited access to advanced equipment and technology. Complete blood count (CBC), which is commonly used in these hospitals, offers the advantages of being cost-effective and easily accessible. This study aims to evaluate the significance of routine blood indicators in aiding of diagnosing AE-COPD.
PATIENTS AND METHODS: In this research, we enrolled a total of 112 patients diagnosed with AE-COPD, 92 patients with stable COPD, and a control group comprising 60 healthy individuals. Clinical characteristics, CBC parameters, and serum CRP levels were collected within two hours. To assess the associations between NLR/PLR/MLR and CRP by Spearman correlation test. The diagnostic accuracy of NLR, PLR and MLR in AE-COPD was assessed using Receiver Operating Characteristic Curve (ROC) and the area under the curve (AUC). Binary Logistic Regression analysis was conducted for the indicators of NLR, PLR and MLR.
RESULTS: We found that patients with AE-COPD had significantly higher levels of NLR, PLR and MLR in contrast to patients with stable COPD. Additionally, the study revealed a noteworthy correlation between CRP and NLR (rs=0.5319, P<0.001), PLR (rs=0.4424, P<0.001), and MLR (rs=0.4628, P<0.001). By utilizing specific cut-off values, the amalgamation of NLR, PLR and MLR augmented diagnostic sensitivity. Binary logistic regression analysis demonstrated that heightened NLR and MLR act as risk factors for the progression of AE-COPD.
CONCLUSION: The increasing levels of NLR, PLR and MLR could function as biomarkers, akin to CRP, for diagnosis and assessment of acute exacerbations among COPD patients. Further research is required to validate this concept.
Mammoplasty is a surgery commonly used for macromastia. Many mammoplasty techniques are described, all with their specific pros and cons. However, the concern to avoid serious complications sometimes takes precedence, and the ideal result cannot be. For macromastia and severely ptotic breasts, usually the free nipple-areolar complex (NAC) mammoplasty technique is implemented. The results, however, may only be completely satisfactory regarding cosmetics. Loss of NAC, poor appearance, flabbiness, flattening, and ptosis are among the disadvantages of this technique. This study aimed to present the results of mammoplasty employing the superomedial pedicle technique without interrupting a macromastia central base with a pedicle length of 8 to 18 cm. According to the literature, many plastic surgeons recommend the free NAC rather than the pedicle technique because of the high complication rates in mammoplasties planned for highly ptotic breasts and macromastia. On the other hand, many free NAC techniques and their modifications with pedicle mammoplasty are described. The general conviction is that a standard method, protocol, or technique good for all patients does not exist. Our results are more acceptable both cosmetically and physiologically. Therefore, the superomedial pedicle technique can be modified to achieve ideal results where free NAC mammoplasty is considered for severe macromastia and ptotic patients. This combined method contributes to the viability of NAC by increasing blood supply to breast tissue and providing an ideal breast appearance.
Application of a topical anesthetic cream to the infusion site prior to administration of VYONDYS 53 may be considered. 

VYONDYS 53 is administered via intravenous infusion. Flush the intravenous access line with 0.9% Sodium Chloride Injection, USP, prior to and after infusion. 

Infuse the diluted VYONDYS 53 over 35 to 60 minutes via an in-line 0.2 micron filter. Do not mix other medications with VYONDYS 53 or infuse other medications concomitantly via the same intravenous access line with VYONDYS 53. 

If a hypersensitivity reaction occurs, consider slowing the infusion, interrupting, or discontinuing the VYONDYS 53 therapy [see Contraindications (4), Warnings and Precautions (5.1,) and Adverse Reactions (6.1)].
The therapeutic effects of alpha lipoic acid (LA) and/or caffeine-loaded chitosan nanoparticles (CCNPs) on obesity-induced memory impairment were evaluated in the present study. Rats were divided into control rats, obese rats induced by high fat diet (HFD) and obese rats treated with LA and/or CCNPs. Obesity was confirmed by measuring the body mass index (BMI). Memory and cognitive functions were evaluated by novel object recognition test (NORT). The levels of serotonin (5-HT), dopamine (DA), norepinephrine (NE), lipid peroxidation (MDA), nitric oxide (NO), reduced glutathione (GSH), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), leptin (LEP) and ghrelin (GHR) and the activities of monoamine oxidase (MAO), acetylcholinesterase (AchE) and Na+,K+,ATPase were determined in the cortex and hippocampus. The cerebral histopathological alterations were examined in obese rats. Obese rats showed impaired memory and exhibited significant neurochemical changes, including decreased levels of 5-HT, DA, GSH, GHR, and Na+,K+-ATPase activity, as well as an increase in AchE, MAO, MDA, NO, IL-1β, TNF-α, and LEP. LA and/or CCNPs treatment reduced BMI and improved memory. LA or CCNPs alleviated the cortical and hippocampal neurochemical changes and histopathological changes induced by obesity. Furthermore, LA and CCNPs exhibited antioxidant and anti-inflammatory properties, which likely contributed to their effects. However, no synergistic effect was observed between LA and CCNPs. These findings suggest that LA or CCNPs may be a potential therapy against obesity and its adverse effects on memory, mediated by their ability to restore monoamine levels and exhibit antioxidant and anti-inflammatory properties.
BACKGROUND: Cachexia a multifactorial syndrome is a common sequala in patients with cancer. It varies from 42 to 80% depending upon the oncological stage and is directly responsible for 30% of deaths in these patients. Previous research from our laboratory demonstrated that peritoneal ovarian cancer generated in NSG mice resulted in skeletal and cardiac muscle atrophy - leading to loss of skeletal muscle mass and strength, and cardiac dysfunction (cachexia). Treatment of mice bearing i.p. tumors with withaferin A (WFA) showed reversal of skeletal muscle and cardiac cachexia. The present study is focused on determining effects of peritoneal ovarian tumors on kidney damage and effects of WFA treatment on ameliorating kidney damage.
METHODS: We generated intraperitoneal ovarian cancer by injecting female NSG mice with ovarian cancer cell line (A2780). After one week of injecting cancer cells, mice were treated with WFA (4 mg/kg) every third day, for three weeks. After 4 weeks of injection of cancer cells, the mice were sacrificed and various tissues including kidney and blood were collected, snap-frozen in liquid nitrogen, and stored at -800C. The presence of kidney biomarker creatinine, was measured in the plasma by an ELISA. The mRNA was isolated from mouse kidneys and was used to examine the expression levels of signaling proteins, inflammatory cytokines, and genes responsible for inducing cachexia (IL-1β, IL-6, TNF-α, TGF-β, GDF-15, and MYD88).
RESULTS: Our results showed a significant increase in levels of expression of inflammatory cytokine IL-1 β (p < 0.01), IL-6 (p < 0.001), TNF-α (p < 0.001), and other related genes including TRAF6 (p < 0.01), MYD88 (p < 0.01), and GDF-15 (p = 0.005) in tumor-bearing mice compared to controls. Treatment of mice bearing tumors with WFA attenuated the increase in expression of each gene. In addition, our results showed a significant increase in creatinine levels in circulation in tumor-bearing mice compared to control mice. Treatment of tumor-bearing mice with WFA resulted in a significant decrease in plasma creatinine levels compared to tumor-bearing mice.
CONCLUSIONS: Our results conclude that ovarian tumors in NSG mice caused kidney damage and renal dysfunction, which was effectively ameliorated by WFA treatment, suggesting a protective effect of WFA on kidney injury induced by ovarian cancer.
Patients should be informed of the following serious and potentially serious adverse reactions that have been associated with ZITHROMAX®

Diarrhea: Inform patients that diarrhea is a common problem caused by antibacterial drugs which usually ends when the antibacterial is discontinued. Sometimes after starting treatment with antibacterials, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibacterial. If this occurs, patients should notify their physician as soon as possible. 

This product's label may have been updated. For current full prescribing information, please visit www.pfizer.com.

LAB-0024-23.0
Novel .alpha.-substituted Trp dipeptoid derivatives cyclized at the C-terminal useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. They are agents useful for preventing the response to the withdrawal from chronic treatment with or use of nicotine, diazepam, alcohol, cocaine, caffeine, or opioids. The compounds of the invention are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the compounds as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the compounds in diagnostic compositions.
Propofol, known chemically as 2, 6-diisopropyl phenol, is an organic compound with the chemical formula C12H18O and is a short-acting intravenous anesthetic used for the induction and maintenance of general anesthesia. It is often used in conjunction with epidural or spinal anesthesia, as well as with analgesics, muscle relaxants, and inhalation anesthetics.
The invention relates to application of a chloride ion channel inhibitor lanjiquinone in an anti-diarrhea drug. Intestinal canal Cl ‑ The channel is used as a key channel for intestinal fluid secretion and becomes a potential diarrhea treatment target. The invention relates to Lanceoquinone p-intestinal Cl ‑ Discovery of channel inhibitory activity, particularly therapeutic effects of oral lanugo quinone on bacterial and viral induced diarrhea. Studies have shown that lanugenon reversibly inhibits TMEM16A channel activity against CaCC and CFTR Cl ‑ The channels also have an inhibitory effect. The gavage lanuginose can reduce intestinal juice secretion induced by STa and CT, and obviously improve diarrhea symptoms induced by cholera toxin and rotavirus. In addition, intestinal motility studies have shown thatThe snow quinone can obviously slow down intestinal peristalsis and inhibit contraction of intestinal smooth muscle, but has no obvious influence on contraction frequency. The lanugenone can be applied to medicines for treating cholera, traveler's diarrhea and rotavirus diarrhea, develops new pharmacological activity of the lanugenone, and provides a new choice for research and development of anti-diarrhea medicines.
The present invention is a nursing operation system that imports patient diagnosis from a related group DRG into a clinical path. The system includes subsystems of activated clinical path, medical order confirmation, nursing assessment, diet information, nursing record, health education, nursing note, and others. The system uses disease diagnosis, surgical treatment, presence or absence of complications/comorbidities, age, gender, discharge status, etc. as classification variables to classify common and similar resource consumed cases into groups based on the ICD-9-CM diagnostic classification. After the National Health Insurance Administration of the Ministry of Health and Welfare sets a relative weight quota, hospitals are responsible for their own profits and losses. Through the above-mentioned system, when a patient is admitted to a hospital, the system automatically determines the diagnosis and imports a DRG diagnosis method of this related group to correspond to a nursing operation set of a corresponding clinical path. The system is built in a nursing operation system based on the clinical path to serve as a basis for nursing cares provided by nurse practitioners to perform comprehensive nursing cares to the patient. The nursing care providers can have concept of managing costs while maintaining appropriateness and quality of medical cares.
The invention discloses colla corii asini and yam composite prepared wine and a preparation method thereof. The colla corii asini and yam composite prepared wine is prepared from the following raw materials in parts by weight: 2 to 3 percent of yam, 2 to 3 percent of colla corii asini, 0.5 to 1.5 percent of wolfberry fruits, 0.5 to 1.5 percent of spina date seeds, 0.5 to 1.5 percent of radix angelicae sinensis and the balance baijiu. The raw materials of the composite prepared wine are medical and edible materials; experiments prove that the good curative effect is achieved. The medicinal material soaking time and the two-stage filtering medicine liquid are finally determined through the long-time experiments. The wine liquid is subjected to two-stage filtering; substances causing turbidity precipitation in the wine can be removed; the effect of improving the quality and the clarity of medicinal wine can be achieved. The composite prepared wine provided by the invention is suitable for relieving symptoms of people groups with menoxenia, people groups with gynecological diseases, people groups with weakness in spirit and force due to deficiency of Qi and blood, people groups with liver stagnation, and the like.
Once the clinician locates the MTrP, he will insert the needle over it and he will do a quick entry of the needle. The chosen technique to manipulate the needle will be Hong technique, which consist of quick entry and exit of the needle (fast in/fast out) to get local twitch response (LTR), it will be repeated 5 times with a rhythmic movement of 1Hz/sec. LTRs will be counted and registered.
Balance control is an important component even in a very simple daily task like walking. However, as we age, our physical and visual function would gradually deteriorate even in the absence of health or eye problems. Improving elderly balance control through different training is one way to prevent falls. In our project, we investigate the use of action video games, which is easy-to-find and entertaining, as a visual function trainer to improve balance of older adults.

We hypothesize that the training would show an improvement in both balance and dynamic vision. Our primary hypothesis is that postural sway in static and dynamic balance measures will improve after action video-game intervention. For secondary outcome measures, we hypothesize that the training will improve dynamic visual function (as measured by dynamic visual acuity and dynamic contrast sensitivity), and visual attention measures (as measured by useful field of view, multiple object tracking and spatial attention).
PURPOSE: To provide a compsn. which consists of pellets contg. a specific acid control agent and chlorine-contg. electrolyte and sodium bicarbonate and relatively increases the milk fat production of ruminants. CONSTITUTION: This compsn. consists of (A) the pellets which contain the sodium acid control agent, such as sodium hydroxide, and/or the magnesium acid control agent, such as magnesium oxide, and the chlorine-contg. electrolyte, contains potassium, sodium and chlorine at such ratios as to contain the potassium at 1.5 to 1.8 parts and the chlorine at 1.2 to 1.5 parts per 1 part sodium by weight and is made present with the potassium at a ratio of 0.8 to 1 pt.wt. per 1 pt.wt. magnesium and (B) the sodium bicarbonate. The ratio of the component A to the component B is preferably 1:8 to 8:1 by weight.
PROBLEM TO BE SOLVED: To obtain a solid aqueous cosmetic such as a foundation, having fixed physical stability, excellent in touch in use such as a refreshing feeling, an enriching feeling, fresh-looking, etc., by combining a specific fatty acid with ammonia and water. SOLUTION: This solid aqueous cosmetic is obtained by combining a fatty acid with ammonia as essential components showing solidifying action. The solid aqueous cosmetic comprises 1.0-20.0wt.% fatty acid, 0.005-5.0wt.% ammonia and 30.0-98.0wt.% water based on the total composition weight. A 10-32C straight-chain or branched chain saturated or unsaturated aliphatic monocarboxylic acid, especially a 10-32C straight-chain saturated fatty acid is preferable as the fatty acid. For example, lauric acid, myristic acid, palmitic acid, stearic acid, etc., may be cited as the fatty acid. The solid aqueous cosmetic can be solidified and is conveniently portable while maintaining merits of an oil-in-water type cosmetic. The solid aqueous cosmetic is excellent in removing make-up with a coating tool such as sponge, etc.
The invention discloses a preparation method of a ginseng solution to improve memory. The ginseng solution comprises the following components (dry): 4-15 parts of ginseng, 3-15 parts of bighead atractylodes rhizome, 10-30 parts of Desmodium styracifolium, 10-15 parts of motherwort, 10-20 parts of Astragalus mongholicus, and 8-25 parts of purslane. Ethanol with concentration of 4%-15% is used for leaching (volume ratio); the first leaching time of the ginseng solution is 10 to 20 days, and the second leaching time is 3-7 days. The preparation method of the ginseng solution to improve memory has the advantages of simple operation, high safety, low cost, and no toxicity or side effect. According to the formation of long-term chronic diseases, the ginseng solution cures symptoms and root causes, namely to reduces blood viscosity, clears  blood, clears cholesterol garbage on the blood vessel walls, softens blood vessels, benefits qi for activating blood circulation, and meets the needs of nutrients and oxygen by the body organs and cells. The prescription is combined with the efforts of medicines to treat multiple symptoms, and is conducive to the radical cure of one disease by improving memory.
PURPOSE: A composition conaining Oldenlandia diffusa extract for skin cosmetic or beauty as an active ingredient is provided to promote differentiation of human mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for differentiation of adipocyte contains Oldenlandia diffusa extract as an active ingredient. The composition is for increasing adipose tissue. The composition promotes differentiation of human mesenchymal stem cells to adipocyte. The human mesenchymal stem cells are mesenchymal stem cells from human bone marrow. The cosmetic composition is used in the form of massage cream, nutrition cream, pack, and gel.
NEW MATERIAL:A compound expressed by formula I (n is 1 or 2; R is H or methyl). EXAMPLE:(E)-3-(1,2-Dithiolan-3-yl)-acrylic acid. USE:An immunological regulator effective for diseases under immunosuppressive conditions, e.g. infectious diseases or cancer, and further for diseases requiring immunological regulation, e.g. various allergies. PREPARATION:2,2-Dimethyl-1,3-dithiane-4-carboxylic acid as a starting raw material is subjected to several steps to give a novel compound expressed by formula 3, which is then reacted with a Witting reagent in a solvent to afford a compound expressed by formula 9 (R3 is lower alkoxy, etc.). The result compound expressed by formula 9 is then hydrolyzed with an acid or alkali in a solvent, e.g. tetrahydrofuran (THF), to give a compound expressed by formula 10, which is then oxidized to afford a compound expressed by formula 11. The resultant compound expressed by formula 11 is dissolved in a solvent and reacted in the presence of an acid catalyst to give the aimed compound expressed by formula 12.