anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To provide a milk-like food which has a protein component, such as natural whey protein, phosphate component, fats, carbohydrate and mineral materials which are respectively decreased to prescribed ratios and is low in protein and phosphorus and high in calcium content in spite of a high energy content. CONSTITUTION: This diet therapy food for renal failure patients has the decreased protein component and phosphate component and has the fats, carbohydrate and mineral materials. The protein component of this food is intrinsically formed of the natural protein obtd. from the whey. The food from the natural whey protein, the fats, such as vegetable fats, the carbohydrate, such as dextrin, and the mineral materials is composed to resemble cow's milk in terms of sensation and cooking technique and has a total energy content of 50 to 500kcal/100ml, of which 1 to 10% of the total energy content is formed of the protein component. The phosphorus component of the desired food is below 10mg/protein g. The calcium component may be incorporated into this food up to 300mg/100ml.
PROBLEM TO BE SOLVED: To obtain an anti-obesity composition for suppressing obesity caused by accumulation of fats and controlling complication accompanying obesity by a simple intake. SOLUTION: This anti-obesity composition comprises theanine. Theanine used in the anti-obesity composition of this invention is not particularly restricted. Theanine contained in tea leaves being the main component of tea flavor is known and its content is higher than those of other amino acids. A method for producing theanine used in the invention is not particularly restricted. An organic synthesis method, a fermentation method, a modified method in which an ethylamine derivative such as ethylamine hydrochloride is used instead of ethylamine in these methods, a method for reacting pyroglutamic acid with ethylamine hydrochloride, a plant cell culture method, a method for extraction from tea leaves, etc., may be cited as the method for producing theanine. The fermentation method capable of inexpensively mass producing theanine is preferable.
The cost of the purification process hinders the extensive use of cytosine phosphate guanosine-oligodeoxynucleotides (CpG-ODNs) for shrimp culture. Therefore, this study used a shuttle vector plasmid to carry 60 copies of CpG-ODN 1668 (pAD43-25_60CpG), which can replicate in Escherichia coli and Bacillus subtilis strain RIK1285. The first experiment used a reverse gavage procedure to deliver a substance (PBS [CK], pAD43-25 [P0], and pAD43-25_60CpG [P60], respectively) directly into the anterior midgut of Penaeus vannamei and transcriptome sequence analysis with a reference genome was performed to examine the expression of well-known immune-related genes. The results showed that the expression levels of immune-related genes in P60 group were significantly increased, particularly those associated with AMPs. In addition, using RT‒qPCR, the expression levels of AMP genes (LvALF, LvPEN-2, and LvPEN-3) in the P60 group may vary depending on the tissue and time point. The second experiment used dietary supplementation with three kinds of heat-killed B. subtilis (HKBS, HKBS-P0, and HKBS-P60) in 28 days of feeding experiments. The results showed that dietary supplementation with HKBS-P60 did not significantly improve shrimp growth performance and survival. However, on days 14 and 28 of the feeding regimens, alkaline phosphatase (AKP) and acid phosphatase (ACP) activity were considerably higher than in other treatments. In addition, following infection with Vibrio harveyi, AKP and ACP activity in the HKBS-P60 group was significantly higher than in other treatments, particularly at the early stage of bacterial infection. Moreover, HKBS-P60 was found to be better protected against V. harveyi infection with lower cumulative mortality (60%) compared to HKBS (90%) and HKBS-P0 (100%) at 7 days after infection. Overall, these findings confirmed that P60 could increase immunological responses in the shrimp midgut, and HKBS-P60 could be used as an effective tool to enhance the immune response and disease resistance in shrimp.
The study will be conducted on 60 patients ASA class I - III BPH patients, candidates for TURP surgery using monopolar electronic resectoscope. Eligible patients will be allocated into one of three study groups (n=20 in each). Group A patients will receive NaCl 3% HS at a dose of 4 ml/kg/hr; Group B patients will receive NaCl 3% HS at a dose of 2 ml/kg/hr; while Group C patients will receive NaCl 0.9% Normal Saline(NS) at a dose of 6 ml/kg/hr. All intra-venous infusions will be started 30 minutes before the subarachnoid block, and continued all through the procedure at the same specific rate for each infusion. Vital signs \[mean BP, HR, CVP \& oxygen saturation (spO2)\] will be recorded. Plasma electrolytes (sodium, potassium, chloride)and serum osmolality (mOsm) will be measured. Incidence of TUR syndrome, need for ICU admission, post-operative ventilation and total hospital stay will be noted.
OBJECTIVE: To describe the clinical and ultrasound characteristics of recurrent granulosa cell and Sertoli-Leydig cell tumors.
METHODS: This was a retrospective observational study performed at Fondazione Policlinico Universitario A. Gemelli, Istituto di Ricovero e Cura a Carattere Scientifico, IRCCS, Rome (Gemelli center), Italy. Patients with a histological diagnosis of recurrent granulosa cell tumor or Sertoli-Leydig cell tumor were identified from the database of the Department of Gynecological Oncology. Those who had undergone a preoperative ultrasound examination at the Gemelli center between 2012 and 2020 were included, and the data retrieved from the original ultrasound reports. In all of these reports, the recurrent tumors were described using International Ovarian Tumor Analysis (IOTA) terminology. If a patient had more than one episode of relapse, information from all episodes was collected. If there was more than one recurrent tumor at the same ultrasound examination, all tumors were included. One expert sonographer also reviewed all available ultrasound images to identify typical ultrasound patterns using pattern recognition.
RESULTS: We identified 30 patients with a histological diagnosis of recurrent granulosa cell tumor (25 patients, 55 tumors) or Sertoli-Leydig cell tumor (five patients, seven tumors). All 30 had undergone at least one preoperative ultrasound examination at the Gemelli center and were included. These women had a total of 66 episodes of relapse, of which a preoperative ultrasound examination had been performed at the Gemelli center in 34, revealing 62 recurrent lesions: one in 22/34 (64.7%) episodes of relapse, two in 4/34 (11.8%) episodes and three or more in 8/34 (23.5%) episodes. Most recurrent granulosa cell tumors (38/55, 69.1%) and recurrent Sertoli-Leydig tumors (6/7, 85.7%) were classified as solid or multilocular-solid tumors, while 8/55 (14.5%) recurrent granulosa cell tumors and 1/7 (14.3%) recurrent Sertoli-Leydig cell tumors were unilocular cysts and 9/55 (16.4%) recurrent granulosa cell tumors were multilocular cysts. The nine unilocular cysts had contents that were anechoic (n = 2) or had low-level echogenicity (n = 7), had either smooth (n = 4) or irregular (n = 5) internal cyst walls, and ranged in largest diameter from 8 to 38 mm, with three being < 20 mm and five being 20-30 mm. On retrospective review of the images, two typical ultrasound patterns were described: small solid tumor measuring < 2 cm (15/62, 24.2%) and tumor with vascularized echogenic ground-glass-like content (12/62, 19.4%).
CONCLUSIONS: Some granulosa cell and Sertoli-Leydig cell recurrences manifest one of two typical ultrasound patterns, while some appear as unilocular cysts. These are usually classified as benign, but in patients being followed up for a granulosa cell tumor or Sertoli-Leydig cell tumor, a unilocular cyst should be considered suspicious of recurrence. © 2023 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
BACKGROUND: In patients with biliary atresia (BA), severe portal hypertension (HTN) develops even with successful bile flow restoration, suggesting an intrinsic factor driving portal HTN independent from bile obstruction. We hypothesize that patients with BA have abnormal portal vein (PV) development, leading to PV hypoplasia.
METHODS: In this observational cohort study, we enrolled patients who were referred to a tertiary center from 2017 to 2021 to rule out BA. Newborns who underwent computed tomography angiogram as a clinical routine before intraoperative cholangiogram, and laparoscopic Kasai hepatoportoenterostomy. The diameter of the PV and hepatic artery (HA) were compared to the degree of liver fibrosis in the wedge biopsies. The jaundice clearance, native liver survival, and clinical portal hypertensive events, including ascites development and intestinal bleeding, were assessed.
RESULTS: 47 newborns with cholestasis were included in the cohort; 35 were diagnosed with BA. The patients with BA had a smaller median PV diameter (4.3 vs. 5.1 mm; p < 0.001) and larger median HA diameter (1.4 vs. 1.2 mm; p < 0.05) compared to the patients with other forms of cholestasis. The median PV and HA diameter did not correlate with the degree of liver fibrosis. Among 35 patients with BA, 29 patients (82.9%) achieved jaundice clearance, and 23 patients (65.7%) were alive with their native liver at two years of age. Seven patients (20%) developed intestinal bleeding, and seven patients (20%) developed ascites, with one overlapping patient.
CONCLUSION: PV hypoplasia is present in patients with BA independent of liver fibrosis at the time of diagnosis.
Although concern persists regarding possible adverse effects of consumption of synthetic azo food dyes, the mechanisms of any such effects remain unclear. We have tested the hypothesis that chronic consumption of the food dye Sunset Yellow (SY) perturbs the composition of the gut microbiota and alters gut integrity. Male rats were administered SY orally for 12 weeks. Analysis of fecal samples before and after dye administration demonstrated SY-induced microbiome dysbiosis. SY treatment reduced the abundance of beneficial taxa such as Treponema 2, Anaerobiospirillum, Helicobacter, Rikenellaceae RC9 gut group, and Prevotellaceae UCG-003, while increasing the abundance of the potentially pathogenic microorganisms Prevotella 2 and Oribacterium. Dysbiosis disrupted gut integrity, altering the jejunal adherens junction complex E-cadherin/β-catenin and decreasing Trefoil Factor (TFF)-3. SY administration elevated LPS serum levels, activated the inflammatory inflammasome cascade TLR4/NLRP3/ASC/cleaved-activated caspase-1 to mature IL-1β and IL-18, and activated caspase-11 and gasdermin-N, indicating pyroptosis and increased intestinal permeability. The possibility that consumption of SY by humans could have effects similar to those that we have observed in rats should be examined.
This study revisits the mathematical SIR/SEIR epidemic models, aiming to introduce novel exponential-type series solutions. Beyond standard non-dimensionalization, we implement a successful rescaling technique that reduces the parameter count in classical epidemiology. Consequently, solutions for the SIR model are determined solely by the basic reproduction number and initial infected fractions. Similarly, the SEIR model requires only the transmission-to-recovery ratio and initial exposed fractions. We present both numerical and non numerical solutions, alongside elucidating the limitations on the existence of exponential-type series solutions. Our analysis reveals that these solutions are valid under two key conditions: endemic situations and early epidemic stages, where the basic reproduction number is close to one. We graphically illustrate the range of physical parameters guaranteeing the existence of non numerical exponential series solutions. However, for epidemic/pandemic outbreaks with significantly higher reproduction numbers, achieving complete convergence of the exponential series across the entire physical domain becomes impossible. In such cases, we divide the exponential series solution into two zones: from initial time to peak time and from peak time to the final epidemic time. For the first zone, where convergence is slow, we successfully employ Padé approximants to accelerate the convergence of the series. This accelerated solution is then smoothly joined to the second zone solution once the peak time is identified within the first region. The presented non numerical solutions are envisioned to serve as valuable benchmarks for testing and enhancing other numerical approaches used to solve epidemic models and their variants.
A process for improving a purity and/or whiteness degree of a talc powder is disclosed. A talc powder with a particle size of about 0.8 mm or less containing impurities such as asbestos, etc. is treated with a phosphoric acid agent under heating at from 70° to 250° C. to remove impurities such as asbestos, etc. by utilizing the difference in the rate of dissolution as between the talc and the impurities. The phosphoric acid agent is one selected from the group consisting of phosphoric acid, pyrophosphoric acid, sodium phosphate, ammonium phosphate, calcium phosphate, sodium tripolyphosphate, sodium pyrophosphate, sodium hexametaphosphate and mixtures thereof. Thus, asbestos, which is considered to be carcinogenic, can be effectively removed from talc.
Patients undergo surgery per standard of care within 6 weeks of randomization. Starting within 84 days of surgery, patients may undergo IGRT with IMRT for 5 fractions per week for 6 weeks as clinically indicated. Patients also undergo CT, MRI, and/or PET/CT on study, and CT and/or MRI during follow up. Patients may also undergo optional collection of tissue, whole blood, and plasma on study.
AIMS: To compare the efficacy and deficiency of conservative management (CM), microsurgery (MS) only, and microsurgery with preoperative embolization (E + MS) for unruptured arteriovenous malformations (AVMs).
METHODS: We prospectively included unruptured AVMs undergoing CM, MS, and E + MS from our institution between August 2011 and August 2021. The primary outcomes were long-term neurofunctional outcomes and hemorrhagic stroke and death. In addition to the comparisons among CM, MS, and E + MS, E + MS was divided into single-staged hybrid and multi-staged E + MS for further analysis. Stabilized inverse probability of treatment weighting using propensity scores was applied to control for confounders by treatment indication across the three groups.
RESULTS: Of 3758 consecutive AVMs admitted, 718 patients were included finally (266 CM, 364 MS, and 88 E + MS). The median follow-up duration was 5.4 years. Compared with CM, interventions (MS and E + MS) were associated with neurological deterioration. MS could lower the risk of hemorrhagic stroke and death. Multi-staged E + MS was associated with neurological deterioration and higher hemorrhagic risks compared with MS, but the hybrid E + MS operation significantly reduced the hemorrhage risk.
CONCLUSION: In this study, unruptured AVMs receiving CM would expect better neurofunctional outcomes but bear higher risks of hemorrhage than MS or E + MS. The single-staged hybrid E + MS might be promising in reducing inter-procedural and subsequent hemorrhage.
PROBLEM TO BE SOLVED: To obtain a dental cement composition keeping excellent properties of a conventional dental cement and, also having excellent kneading property and further, higher bonding strength by using dental cement having an average particle diameter in a specific range and high sphericity. SOLUTION: This dental composition is obtained by using dental cement powder having an average particle diameter of 0.01-20μm and a sphericity (Fx) of 0.50-0.95. The dental clement powder is preferably glass ionomer cement powder or calcium α-phosphate powder. The composition contains the clement powder and an aqueous solution of an organic acid. The organic acid is preferably acrylic acid, methacrylic acid, maleic acid, etc. The concentration of the aqueous solution is about 25-60wt.%. The working time using the composition is short since the composition is easily obtained, and also the paste-state composition is hardly dissolve in water and the restoration or bonding work of a tooth using the composition is easy. Further, the composition has a strong compressive strength and a low decay rate.
Carisoprodol Tablets, USP are available as 350 mg, round, white tablets for oral administration. Carisoprodol is a white, crystalline powder, having a mild, characteristic odor and a bitter taste. It is slightly soluble in water; freely soluble in alcohol, in chloroform, and in acetone; and its solubility is practically independent of pH. Carisoprodol is present as a racemic mixture. Chemically, carisoprodol is (±)-2-Methyl-2-propyl-1,3-propanediol carbamate isopropylcarbamate and the molecular formula is C 12H 24N 2O 4, with a molecular weight of 260.33. The structural formula is: 

  
Other ingredients in Carisoprodol Tablets, USP include lactose monohydrate NF, sodium starch glycolate NF, povidone NF, sodium lauryl sulfate NF, microcrystalline cellulose (PH 101) NF, and magnesium stearate NF.
It is presently not known whether endogenous neuroactive steroid hormone trajectories across the menstrual cycle are distinguishable in women with premenstrual dysphoric disorder (PMDD). To improve the rigor in this area of research, we implemented a validated study methodology, involving blood sample collection at 8 key menstrual cycle timepoints, following which the study data is realigned so that all women are compared at the same biological window (i.e., menstrual cycle subphase). Using liquid chromatography-mass spectrometry (LC-MS), we analyzed serum levels of nine steroid hormones previously implicated in the etiology of PMDD, including allopregnanolone. Other than progesterone (p ≤ 0.001), none of the steroid hormones displayed significant changes across menstrual cycle subphases when comparing participants with PMDD to the healthy controls. A thorough investigation of the progesterone trajectory showed that its left shift in the luteal phase (e.g., earlier rise in progesterone) exposes women with PMDD to a higher periovulatory progesterone and a more acute withdrawal in the late luteal subphase. Results of the present study indicate that the largely overlooked brief periovulatory subphase should be thoroughly examined in PMDD and agree with prior conclusions that rapid progesterone withdrawal associates with the development of negative affect.
BACKGROUND: Myocardial ischemia/reperfusion (I/R) injury is a common pathological process in clinical practice. Developing effective therapeutic strategies to reduce or prevent this injury is crucial. The article aimed to investigate the role and mechanism of mesencephalic astrocyte-derived neurotrophic factor (MANF) and its key subdomains in modulating myocardial I/R-induced cardiomyocyte apoptosis.
METHODS: MANF stable knockout cell line and MANF mutant overexpression plasmids were constructed. The effects of MANF and mutants on apoptosis and endoplasmic reticulum (ER) stress related proteins were evaluated in hypoxia/reoxygenation-induced HL-1 cardiomyocytes by western blot, immunofluorescence, Tunel and flow cytometry. Echocardiography, ELISA, TTC and Masson were used to observe the effects of recombinant MANF protein (rMANF) on cardiac function in myocardial I/R mice.
RESULTS: This study observed increased expression of MANF in both myocardial infarction patients and I/R mice. MANF overexpression in cardiomyocytes decreased ER stress-induced apoptosis, while MANF knockout exacerbated it. rMANF improved cardiac function in I/R mice by reducing injury and inflammation. This study specifically demonstrates that mutations in the α-helix of MANF were more effective in reducing ER stress and cardiomyocyte apoptosis. Mechanistically, MANF and the α-helix mutant attenuated I/R injury by inhibiting the JAK1/STAT1/NF-κB signaling pathway in addition to reducing ER stress-induced apoptosis.
CONCLUSION: These findings highlight MANF and its subdomains as critical regulators of myocardial I/R injury, offering promising therapeutic targets with significant clinical implications for I/R-related diseases.
Dihydrocodeine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.

Respiratory Depression:

Respiratory depression is the most dangerous acute reaction produced by opioid agonist preparations, although it is rarely severe with usual doses. Opioids decrease the respiratory rate, tidal volume, minute ventilation, and sensitivity to carbon dioxide. Respiratory depression occurs most frequently in elderly or debilitated patients, usually after large initial doses in nontolerant patients, or when opioids are given in conjunction with other agents that depress respiration. This combination product should be used with caution in patients with significant chronic obstructive pulmonary disease or corpulmonale and in patients with a substantially decreased respiratory reserve, hypoxia, hypercapnia, or respiratory depression. In such patients, alternative non-opioid analgesics should be considered, and opioids should be admin- istered only under careful medical supervision at the lowest effective dose.
PURPOSE:To provide the title composition having a combination of high platelet and blood coagulation inhibitory activity, containing, as active ingredient, a protein with a specific amino acid sequence in at least part thereof. CONSTITUTION:The objective composition containing, as active ingredient, a protein with an amino acid sequence of the formula in at least part thereof. Said amino acid sequence corresponds to that of a portion considered to be important for protease inhibitory activity in a region with such activity in a senile maculoamyloid precursor protein. The protein having said amino acid sequence highly inhibits blood coagulation factor X1a, also having cell proliferation stimulative activity. The present composition is useful for preventing reobstruction after PTCR or PTCA, therapies of thrombosis in the heart etc., and preventing the relapse of cerebral infarction after its attack and its therapy, being also useful for therapies of disseminated intravascular coagulation due to various basal diseases (e.g. serious infectious diseases, malignant tumors).
Techniques relate to analyzing image data to determine an annuloplasty ring to implant for an annuloplasty procedure. For example, image data can be received that depicts a heart valve. The image data can be analyzed to identify one or more image features that represent one or more anatomical features of the heart valve. Based on the one or more image features, heart data can be generated that indicates a measurement and/or another characteristic of the heart valve. An annuloplasty ring can be determined based on the heart valve data and/or annuloplasty ring data indicating characteristics of one or more annuloplasty rings. User interface data can then be generated that indicates the annuloplasty ring.
Parent-Youth dyads assigned to the iKinnect2.0 condition will be given access to the iKinnect2.0 app that has been developed for this study. Parent and youth will be asked to download the app to their phone during the baseline assessment process and asked to use it as often as they would like throughout the duration of the 16 week trial. The app is designed to be used several times throughout each day.