anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Temperature elevation drastically affects plant defense responses to Ralstonia solanacearum and inhibits the major source of resistance in Arabidopsis thaliana, which is mediated by the receptor pair RRS1-R/RPS4. In this study, we refined a previous genome-wide association (GWA) mapping analysis by using a local score approach and detected the primary cell wall CESA3 gene as a major gene involved in plant response to R. solanacearum at both 27°C and an elevated temperature, 30°C. We functionally validated CESA3 as a susceptibility gene involved in resistance to R. solanacearum at both 27 and 30°C through a reverse genetic approach. We provide evidence that the cesa3mre1 mutant enhances resistance to bacterial disease and that resistance is associated with an alteration of root cell morphology conserved at elevated temperatures. However, even by forcing the entry of the bacterium to bypass the primary cell wall barrier, the cesa3mre1 mutant still showed enhanced resistance to R. solanacearum with delayed onset of bacterial wilt symptoms. We demonstrated that the cesa3mre1 mutant had constitutive expression of the defense-related gene VSP1, which is upregulated at elevated temperatures, and that during infection, its expression level is maintained higher than in the wild-type Col-0. In conclusion, this study reveals that alteration of the primary cell wall by mutating the cellulose synthase subunit CESA3 contributes to enhanced resistance to R. solanacearum, remaining effective under heat stress. We expect that these results will help to identify robust genetic sources of resistance to R. solanacearum in the context of global warming. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license.
One in ten people aged between 55-74 years have a significant hearing impairment in their better hearing ear (as defined by audiometric hearing thresholds). Yet, it is becoming increasingly clear that the challenges faced by older listeners cannot be explained by the audiogram. The ability for people with hearing loss to use cognition to support context allows for compensation of degraded auditory input, which in turn offers promise for new cognitive-based rehabilitative interventions. Working memory is known to be highly associated with language and recent evidence has shown significant generalisation of on-task learning from Cogmed working memory training to improvements in sentence-repetition skills of children with severe to profound hearing loss and use cochlear implants. This evidence offers support for further investigation into the potential benefits of working memory training to improve speech perception abilities in other hearing impaired populations. This study aims to assess whether Cogmed (adaptive) working memory training improves the listening abilities of adults with mild to moderate hearing loss as assessed using untrained measurers of cognition, speech perception and self-reported hearing ability, compared with an active control (Cogmed, non-adaptive) group. A 6 month follow-up will assess retention of any training-related improvements in outcomes for the adaptive training group.
PROBLEM TO BE SOLVED: To provide a comprehensive method for sterilizing and disinfecting a concentrated and purified fluid of plasma protein component of a patient oneself contained in an apparatus for recovering and generating peritoneal dialyzing fluid and regenerated dialyzing fluid without risk of residual toxicity, and keeping it at aseptic condition. SOLUTION: A concentrated plasma protein fluid is kept on storing acidic condition of a pH of 4-0 and is neutralized with an alkali on the use. Or the concentrated fluid is kept cool at a temperature range from -80 deg.C to 10 deg.C and is warmed to the body heat on the use. A recovering and reclaiming apparatus is sterilized periodically with a storing acidic electrolyzed water the inside thereof. A filter, a semi-permeable membrane concentrator, a disinfected filter 23 at the upstream part of injection catheter 19 are filled with anti-bacterial agent. When a joint part of the apparatus and the catheter 19, 2 are changed, it is irradiated by microwave. On at least two of the above means are applied in a confined manner.
The invention belongs to the field of health-care products and particularly relates to raw fish enzyme, a preparation method of the raw fish enzyme and anti-inflammation and pain relieving paste. The raw fish enzyme is prepared from the raw materials of fruits, sugar, water and raw fish slices. The fruits are fruits high in sugar content. Sugar includes brown sugar and glucose. The raw fish is saltwater fish. The raw fish enzyme have the advantages that the raw fish enzyme can diminish inflammation and relieve pains, has good curative effects on arthritis, shoulder periarthritis and sciatica and can treat seborrheic smallpox.
Participants in the waitlist-control group will receive verbal explanations and caregiver education based on clinician's needs assessment in the course of their child's treatment process. At the end of 8-weeks, they will also receive access to eHOPE.
Case 1:The investigators started the intervention and supplementation of arachidonic acid for 3 patients diagnosed as autistic spectrum disorders (ASD) from September 4, 2010 at Sawa hospital (Osaka, Japan). Another ASD patients (n=5) at Sawa hospital were treated by administration of Risperidone as medicinal drink from January 14, 2011. The supplementation as well as Risperidone administration followed double-blind placebo controlled cross-over protocol to access the effect of the treatment. These trials will continue until November 2011. Final outcome will be evaluated by clinical diagnosis and behavior parameters measurement as described under Brief Summary.

Case 2: The investigators started the intervention and supplementation of reduced form of CoQ10 for learning disability children (n=20) at small private cramming school (JIZAI-ken, Tokyo) from February 5, 2011. This trial will continue until October 2011. The effect of the intervention and supplementation will be evaluated by behavior parameter measurement as described above.
BACKGROUND: Theileria haneyi is one of the three known causative agents of equine piroplasmosis. While imidocarb is generally effective in the clearance of the highly pathogenic Theileria equi, it is ineffective in the treatment of T. haneyi. Moreover, co-infection with T. haneyi has been shown to impede the successful treatment of T. equi. Furthermore, tulathromycin and diclazuril have demonstrated inefficacy in eradicating T. haneyi. The absence of an effective therapeutic agent against this parasite represents a significant obstacle in managing equine piroplasmosis.
METHODS: To address this issue, we evaluated the efficacy of buparvaquone in the treatment of T. haneyi in chronically infected horses.
RESULTS: Our findings showed that treatment of horses with the recommended dose of 2.5 mg/kg of buparvaquone led to a rapid abatement of T. haneyi levels, to a level where the parasites were not detectable by nested PCR. Following treatment, the horses remained PCR negative for a minimum of seven weeks until recrudescence occurred. Subsequent re-administration of buparvaquone at an increased dosage of 6 mg/kg upon recrudescence failed to exert a theilericidal effect on T. haneyi. Throughout the treatment regimen, the hematological parameters of the horses and most components of the chemistry panel remained within the normal range, except for blood urea nitrogen levels, which fell below the normal range in certain instances.
CONCLUSIONS: BPQ at 2.5 mg/kg and 6 mg/kg had a robust theilericidal effect but was ineffective in the clearance of the T. haneyi infection in persistently infected animals.
The invention relates to a Chinese medicinal composition for treating dyspepsia of hepatopathy patients. The Chinese medicinal composition comprises the following components by weight: 30-40 parts of atratylodes rhizome, 30-40 parts of Magnolia officinalis, 30-40 parts of papaya, 30-40 parts of medicated leaven, 20-30 parts of Cyperus rotundus, 20-30 parts of radix bupleuri, 20-30 parts of China rose, 20-30 parts of Radix Linderae, 10-20 parts of fresh ginger, and 10-20 parts of gentian. The Chinese medicinal composition for treating dyspepsia of hepatopathy patients provided by the invention has reasonable prescription. Specifically, the atratylodes rhizome can drying dampness and strengthening spleen, the Magnolia officinalis can promote the circulation of qi, eliminate dampness and remove qi stagnation, the papaya can remove dampness to restore stomach, the medicated leaven can help digestion and harmonize the stomach, and the four drugs together serve as monarch drugs. The Cyperus rotundus can soothe liver and regulate qi flowing, regulate menstruation and relieve pain, the radix bupleuri can soothe liver and resolve depression, the China rose can promote blood circulation to regulate menstruation, dispel depression and diminish swelling, the Radix Linderae can promote qi circulation and relieve pain, and the four drugs together serve as minister drugs. The fresh ginger can relieve exterior syndromes by diaphoresis, warm the middle jiao and arrest vomiting, the gentian can clear away heat and dry dampness, and purge liver fire, and the two drugs together serve as assistant drugs. The ten drugs can be used cooperatively to achieve the efficacy of drying dampness, tonifying spleen, soothing liver and resolving depression. The Chinese medicinal composition provided by the invention has the characteristics of convenient use, significant effect, and can effectively treat dyspepsia of hepatopathy patients.
Multi-phase liquid antiperspirant compositions and antiperspirant products including multi-phase liquid antiperspirant compositions are provided. In one embodiment, a multi-phase liquid antiperspirant composition includes a first liquid phase, a second liquid phase, and a surfactant component. The first liquid phase includes an antiperspirant active compound and water. The second liquid phase includes a cyclomethicone component. The surfactant component is present in the multi-phase liquid antiperspirant composition in an amount sufficient to form an unstable emulsion of the first liquid phase and the second liquid phase upon mixing of the multi-phase liquid antiperspirant composition. The first liquid phase and the second liquid phase separate into visibly distinct layers within the multi-phase liquid antiperspirant composition after a settling time period of less than or equal to 48 hours. In another embodiment, an antiperspirant product includes a container and the multi-phase liquid antiperspirant composition disposed in the container.
According to the CDC, heart disease is the leading cause of death for both men and women of most racial/ethnic groups in the United States, including African Americans, Hispanics, and whites. About 610,000 people die of cardiovascular disease (CVD) every year, accounting for 1 in every 4 deaths (41). Because many known risk factors for heart disease are hereditary, understanding the connection between genetics, particularly heritable polymorphisms, and cardiovascular disease risk is of great importance. This is a cross-sectional, controlled study designed to investigate the association of two single nucleotide polymorphisms (SNPs) - a cytochrome P450 (CYP) epoxygenase gene CYP2J2 SNP, CYP2J2 7, and a soluble epoxide hydrolase (sEH) gene EPHX2 SNP encoding a K55R variant - with altered endothelial function in humans. Healthy adults, aged 18-65 years, who are either carriers of CYP2J2 7 or EPHX2 K55R, or who are wild type (WT) with respect to either SNP will be recruited into a total of five genotype groups. Potential participants will be identified from the Environmental Polymorphisms Registry, mailed an informational letter, contacted by phone and/or email, and pre-screened for eligibility. As participants are recruited, demographic characteristics (i.e., age, gender, and race/ethnicity) will be compared between the groups, and, if necessary, recruitment will be targeted to achieve an approximate match in demographic characteristics across the groups. Pre-screened individuals will provide verbal consent to refrain from taking certain as needed supplements/medications that could alter endothelial function and recreational drugs (such as marijuana, cocaine and amphetamines) prior to the study visit, and will be mailed an informed consent form, medical history form, a urine collection cup, and pre-visit instructions. Participants will attend a single study visit that will take place at the NIEHS Clinical Research Unit. During this visit, written informed consent will be obtained, and there will be a final screening and eligibility determination including medical history review, assessment of vital signs, physical examination, carbon monoxide measurement, pregnancy test (if applicable), and electrocardiogram (ECG). In eligible participants, a lipid panel will be performed and endothelial function will be assessed non-invasively by brachial artery ultrasound (i.e., flow-mediated dilation) and digital peripheral arterial tonometry. Blood and urine (first void) samples will be collected for biomarker analyses, which will be conducted in the Zeldin laboratory at NIEHS. The primary objective of the study is to determine whether individuals who are homozygous or heterozygous for the CYP2J2 7 or EPHX2 K55R SNPs exhibit altered endothelial function compared with individuals who are WT for that SNP. As a secondary objective, the impact of these two SNPs on inflammatory and CYP epoxygenase pathway biomarkers will be examined.
BACKGROUND: The reason for higher incidence of atrial fibrillation (AF) in Europe compared with East Asia is unclear. We aimed to investigate the association between modifiable lifestyle factors and lifetime risk of AF in Europe and East Asia, along with race/ethnic similarities and disparities.
METHODS: 1:1 propensity score matched pairs of 242,763 East Asians and 242,763 White Europeans without AF were analyzed. Modifiable lifestyle factors considered were blood pressure, body mass index, cigarette smoking, diabetes, alcohol consumption, and physical activity, categorized as non-adverse or adverse levels. Lifetime risk of AF was estimated from the index age of 45 years to the attained age of 85 years, accounting for the competing risk of death.
RESULTS: The overall lifetime risk of AF was higher in White Europeans than East Asians (20.9% vs 15.4%, p < 0.001). The lifetime risk of AF was similar between the two races in individuals with non-adverse lifestyle factor profiles (13.4% vs 12.9%, p = 0.575), whereas it was higher in White Europeans with adverse lifestyle factor profiles (22.1% vs 15.8%, p < 0.001). The difference in the lifetime risk of AF between the two races increased as the burden of adverse lifestyle factors worsened (1 adverse lifestyle factor; 4.3% to ≥ 3 adverse lifestyle factors; 11.2%). Compared with East Asians, the relative risk of AF in White Europeans was 23% and 62% higher for one (hazard ratio [HR] 1.23, 95% confidence interval [CI] 1.16-1.29) and ≥ 3 adverse lifestyle factors (HR 1.62, 95% CI 1.51-1.75), respectively.
CONCLUSIONS: The overall higher lifetime risk of AF in White Europeans compared with East Asians might be attributable to adverse lifestyle factors. Adherence to healthy lifestyle factors was associated with the lifetime risk of AF of about 1 in 8 regardless of race/ethnicity.
Vertebral arterial injury (VAI) remains a fatal complication of C1-C2 posterior screw fixation. Herein, we report asymptomatic bilateral VAI that was caused by screws following C1-C2 posterior fixation. A 34-year-old woman with cerebral palsy experienced quadriplegia after a fall. Cervical computed tomography (CT) showed increased ADI, with os odontoideum, for which C1 pedicle screw and C2 pedicle-lamina screw fixation were performed. Cervical magnetic resonance imaging (MRI) conducted for postoperative weakness in shoulder elevation demonstrated a well-decompressed spinal cord. However, neck CT angiography revealed bilateral vertebral artery (VA) violations by the C1 pedicle screw that induced occlusion of the V2 and V3 segments of both VA, with intact V4 segments. Diffusionweighted imaging showed no evidence of infarction. Cerebral angiography showed reconstitution of posterior circulation via the left fetal posterior communicating artery. Steroid treatment-induced improvement in shoulder elevation to the preoperative level, and no neurological deterioration has been detected for 3 years postoperatively. Prevention of VAI is one of the most important objectives when performing posterior cervical screw fixation. The screw should be inserted considering the rotation of C1 and C2. Notably, variations in cerebral circulation, which enable collateral blood flow to the posterior circulation, can lead to different sequelae in patients with iatrogenic VAI.
JNJ-56022473 will be given intravenously to all subjects at a dose of 9 mg/kg once every 14 days for an initial treatment period of 3 months (6 infusions). Responders will then receive up to 20 additional infusions whereas for non-responders the initial treatment will be followed by a up to 9 months observation period without further JNJ-56022473 treatment. Thus, the individual study duration for a subject will be approx. 1 year. A follow up visit will be performed after 3 months after last study drug administration for all patients to track pregnancy status according to IB.
Participants complete interval arm cycling at power output that varies between 2 min "active" and two min "recovery" periods. This interval exercise is matched to the total energy expenditure (accumulated kcals) response during CRT. Following the intervention they are fed.
Childhood mortality related to Plasmodium falciparum malaria is on the rise with more than 1 million deaths per year in Sub-Saharan Africa. In the context of growing drug-resistance to antimalarials health officials are calling for rapid replacement of failing drugs by combining antimalarial drugs. Artemisinin Combination Antimalarial Therapies (ACTs) are in the focus of malaria control programmes and are recommended for first-line treatment in African countries. ACTs have been reported to be highly effective as artemisinin derivatives cause a rapid and substantial decrease in the parasite load when used for treating patients with malaria and resistance to artemisinin is still lacking. However, the short half-lives of artemisinins result in frequent recrudescent infections when used alone and therefore, much interest lays on the choice of the combination partner drug. ACTs also have been proposed as a means of reducing transmission by the reduction of gametocytes and of delaying the spread of drug resistance and prolonging the therapeutic life span of. Nevertheless, drug resistance of parasites to the respective partner drug is a matter of concern. Artesunate-amodiaquine (AQ) and artemether-lumefantrine (AL) are two registered fixed-dose artemisinin combination chemotherapies used in Africa which are GMP-manufactured at industrial scale. There is still limited data from randomised, controlled trials to support the general effectiveness of these two ACTs in Africa, including Ghana. More data is needed to compare these two therapies to make evidence-based first-line treatment decisions. Importantly, it is difficult to predict how combination therapy may affect the spread of drug resistance and monitoring drug resistance markers should be embedded in these trials to guide drug policy decision.

The aim of this open-labelled, randomised drug trial is to compare the effectiveness and safety of artesunate-amodiaquine (Arsucam®) against artemether plus lumefantrine (Coartem®) for the treatment of children under five years of age with uncomplicated Plasmodium falciparum malaria.
In the video-watching group, a patient will follow the exercise instructions from watching the video. The exercise content in video are set during the patient conducting the rehabilitation program. Then, the therapist will select 3 to 5 groups of movements pattern needed to be enhanced catching from the video for the patient to practice when returning the bedside after the rehabilitation programs.
Aminoadamantane derivatives of formula (I) are new (where R1 is H or CH3 and Y is the residue -(CH2)x-H in which x is 1-11). This is an addition to 1941218. (I) have excellent virustatic properties, e.g. against influenza and parainfluenza viruses. Results of in vitro tests are given in the specification. (I) are prepared by reacting a corresponding N-haloacetyl-aminoadamantane with an equimolar amount of the alkali metal alcoholate of Y-OH in the presence of excess Y-OH at elevated temperature, removing the resulting alkali metal halide and the excess Y-OH, and opt. purifying the product by distillation or recrystallization.
FIELD: veterinary science. SUBSTANCE: method involves administration of cytokin in animal organism that activates phagocytes function and immune system and antibiotic. Administration is carried out at period of early lactation or at mammary gland involution. The source of cytokin: interleukin-1-12, interferon of tumor necrosis factor, or colony stimulating factor, or fibroblast growth factor, or granulocyte macrophage stimulating factor, or growth transformation factor, or platelet activating factor, or mutein, or peptide equivalent, its inductor or their combination, and interleukin-2 is used at amount 0.01-40 mg per one-quarter of treated udder, and granulocyte macrophage stimulating agent is used at amount 0.5-55 mg per one-quarter of treated udder. EFFECT: improved method of treatment, enhanced effectiveness. 3 cl, 4 tbl, 9 dwg
The invention discloses a kind of multi-solvent methods to extract the method that the common antineoplastic component of Radix zanthoxyli is separated with Amberlyst process, comprising the following steps: 1. pulverizing medicinal materials；2. enzymatic hydrolysis pretreatment；3. neutral high-strength ethyl alcohol extracts and enrichment；4. acid low-concentration ethanol extracts and enrichment；5. acidic high-strength ethyl alcohol extracts and enrichment；6. merging, the common antineoplastic component mixture of Radix zanthoxyli is obtained.Measuring mixture with mtt assay is 0.04~0.06mg/mL to the half-inhibitory concentration of HepG-2 liver cancer cells, and the half-inhibitory concentration to Hela cervical cancer cell is 0.06~0.08mg/mL.The different acid-base property of the present invention, opposed polarity solvent successively extract, upper macroporous resin column is enriched with respectively, it avoids acid and destroys partial antitumor ingredient, extract the antineoplastic component of opposed polarity to the maximum extent again, and simple process, maximize the gross production rate of common antineoplastic component, total effects maximize, it develops, be prepared into having a high potential for excellent antineoplastic, market prospects are good.
Natural supplementations have many reported effects on the human health ranged from immunity boosting to effective antiviral effect. Omeg-3 as an example affect the human health by many mechanisms e.g. Anti-oxidant, immunity boosting agent. Moreover, Omega-3 exerts an antiviral effect on Flu virus by inhibiting influenza virus replication 1. On the other hand, black seed supplementation exerts a chelation effect on sickle cell anemia patients and inhibits Human Heme Metabolism 2. Moreover, black seed exerts an antiviral effect on the replication of old coronavirus and the expression of (TRP-genes) family 3. In addition, Omega-3 regulates the human immunity against bacterial and viral infections 4. During the past years, many natural sources exerts an antimalarial effect with perfect reported results 5.