anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A method for treating the newly diagnosed disseminated destructive pulmonary tuberculosis. Intravenous introduction of ozonized sodium chloride physiological solution and intravascular laser irradiation of blood (ILIB) are conducted in the setting of the standardized antimicobacterial therapy regimens of intensive phase treatment of pulmonary tuberculosis. Saturating concentration of ozone in physiological solution is grown from 2 mg/l at the first procedure (step - 2 mg/l) to 12 mg/l. Introduction of ozonized physiological solution of this concentration proceeds further to the amount 18 procedures. The first five introductions are conducted daily, and further - every other day, by turns with ILIB. The ILIB is conducted through a cubital vein, power on the end of light pipe - 4,5-5,0 mwatt, frequency modulations - 1000 Hz, duration of procedure - 30 min., amount of seances - 9.
The invention relates to an application of a compound with a bufanolide diene structure mother nucleus in the preparation of medicines for treating sepsis immune paralysis. Cinobufagin derived from an amphibian toad is adopted. Experiments prove that the compound is capable of obviously reversing the survival rate of a mouse with the clinically simulated sepsis immune paralysis which is caused by the cecal ligature and puncture of a mouse and secondary salmonella hit and inhibiting the reduction of CD4+ and CD8+ cells of the spleen and the lymph gland of the mouse with the immune paralysis. On blood mononuclear cells of a clinical severe sepsis patient, the cinobufagin can reverse the reduction of the expression level of TH1 immune stimulating factors such as TNF (tumor necrosis factor)-alpha, GM-CSF (granulocyte-macrophage colony-stimulating factor) and IFN (interferon)-gamma which are caused by sepsis. On a normal human mononuclear cell endotoxin tolerance model which is caused by lipopolysaccharide (LPS), the cinobufagin can effectively reverse the reduction of expression capacity of mononuclear cell TNF alpha caused by secondary lipopolysaccharide hit. The compound has very high development value and application prospect.
The experimental group receives 6 weeks of combined cognitive intervention (GOLD-Cog+),which includes participation in 9, one hour long Cognitive-Orientation to Occupational Performance(CO-OP)-based group sessions and 24 individual and independent 30-minute computerized cognitive training (CCT) program using the Effectivate platform (Israeli-based CCT developed for older adults. Available in both Hebrew and English).
Doxorubicin (DOX) is a commonly administered chemotherapy drug for treating hematological malignancies and solid tumors; however, its clinical application is limited by significant cardiotoxicity. Cynaroside (Cyn) is a flavonoid glycoside distributed in honeysuckle, with confirmed potential biological functions in regulating inflammation, pyroptosis, and oxidative stress. Herein, the effects of Cyn were evaluated in a DOX-induced cardiotoxicity (DIC) mouse model, which was established by intraperitoneal injections of DOX (5 mg/kg) once a week for three weeks. The mice in the treatment group received dexrazoxane, MCC950, and Cyn every two days. Blood biochemistry, histopathology, immunohistochemistry, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and western blotting were conducted to investigate the cardioprotective effects and potential mechanisms of Cyn treatment. The results demonstrated the significant benefits of Cyn treatment in mitigating DIC; it could effectively alleviate oxidative stress to a certain extent, maintain the equilibrium of cell apoptosis, and enhance the cardiac function of mice. These effects were realized via regulating the transcription levels of pyroptosis-related genes, such as nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), caspase-1, and gasdermin D (GSDMD). Mechanistically, for DOX-induced myocardial injury, Cyn could significantly modulate the expression of pivotal genes, including adenosine monophosphate-activated protein kinase (AMPK), peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α), sirtuin 3 (SIRT3), and nuclear factor erythroid 2-related factor 2 (Nrf2). We attribute it to the mediation of AMPK/SIRT3/Nrf2 pathway, which plays a central role in preventing DOX-induced cardiomyocyte injury. In conclusion, the present study confirms the therapeutic potential of Cyn in DIC by regulating the AMPK/SIRT3/Nrf2 pathway.
The study group received 8 weeks of self-management training. Reflections, prepared using Power Point, were used in all sessions. The study employed various methods, including the question-answer and audio-visual methods, as well as performance feedback when necessary during the sessions. Final evaluations were conducted for both groups after eight weeks.
Specific Aim 1.Assess how systemic cannabinoids remodel tumor infiltrating lymphocytes (TILs) within the melanoma tumor microenvironment. We hypothesize that decreased grade of TILs and exhaustive differentiation of T cells in melanoma are associated with lower cannabinoid receptor (CB1/CB2) expression and higher levels of systemic exogenous cannabinoids. Aim 1a.) Correlate plasma levels of cannabinoids with TIL grade. Aim 1b.) Correlate plasma levels of cannabinoids with TIL T cell immunohistochemical markers of exhaustion. Aim 1c.) Correlate plasma levels of cannabinoids to TIL CB1/CB2 expression.

Specific Aim 2. Determine the relationship between peripheral T cell activation and circulating cannabinoid levels in patients with melanoma. We hypothesize that the phenotypic activation of peripheral T cells is inversely associated with increased plasma levels of systemic exogenous cannabinoids. Aim 2a.) Immunophenotype peripheral T cells from patients with melanoma. Aim 2b.) Correlate plasma levels of cannabinoids with peripheral T cell phenotypic activation.
In ALTA 1L, heart rates less than 50 beats per minute (bpm) occurred in 8.1% of patients receiving ALUNBRIG. Grade 3 bradycardia occurred in 1 patient (0.7%).

In ALTA, heart rates less than 50 beats per minute (bpm) occurred in 5.7% of patients in the 90 mg group and 7.6% of patients in the 90→180 mg group. Grade 2 bradycardia occurred in 1 (0.9%) patient in the 90 mg group.

Monitor heart rate and blood pressure during treatment with ALUNBRIG. Monitor patients more frequently if concomitant use of drug known to cause bradycardia cannot be avoided [see Warnings and Precautions (5.2)].

For symptomatic bradycardia, withhold ALUNBRIG and review concomitant medications for those known to cause bradycardia. If a concomitant medication known to cause bradycardia is identified and discontinued or dose adjusted, resume ALUNBRIG at the same dose following resolution of symptomatic bradycardia; otherwise, reduce the dose of ALUNBRIG following resolution of symptomatic bradycardia. Discontinue ALUNBRIG for life-threatening bradycardia if no contributing concomitant medication is identified [see Dosage and Administration (2.3)].
In the last decade tight junction proteins exposed at the surface of liver or cancer cells have been uncovered as mediators of liver disease biology: Claudin-1 and Occludin are host factors for hepatitis C virus entry and Claudin-1 has been identified as a driver for liver fibrosis and hepatocellular carcinoma (HCC). Moreover, Claudins have emerged as therapeutic targets for liver disease and HCC. CLDN1 expression is upregulated in liver fibrosis and HCC. Monoclonal antibodies (mAbs) targeting Claudin-1 have completed preclinical proof-of-concept studies for treatment of liver fibrosis and HCC and are currently in clinical development for advanced liver fibrosis. Claudin-6 overexpression is associated with an HCC aggressive phenotype and treatment resistance. Claudin-6 mAbs or chimeric antigen receptor-T cells therapies are currently being clinically investigated for Claudin-6 overexpressing tumors. In conclusion, targeting Claudin proteins offers a novel clinical opportunity for the treatment of patients with advanced liver fibrosis and HCC.
OBJECTIVE: Randomized controlled trials (RCTs) are a gold standard for estimating the benefits of clinical interventions, but their decision-making utility can be limited by relatively short follow-up time. Longer-term follow-up of RCT participants is essential to support treatment decisions. However, as time from randomization accrues, loss to follow-up and competing events can introduce biases and require covariate adjustment even for intention-to-treat effects. We describe a process for synthesizing expert knowledge and apply this to long-term follow-up of an RCT of treatments for meniscal tears in patients with knee osteoarthritis (OA).
METHODS: We identified 2 post-randomization events likely to impact accurate assessment of pain outcomes beyond 5 years in trial participants: loss to follow-up and total knee replacement (TKR). We conducted literature searches for covariates related to pain and TKR in individuals with knee OA and combined these with expert input. We synthesized the evidence into graphical models.
RESULTS: We identified 94 potential covariates potentially related to pain and/or TKR among individuals with knee OA. Of these, 46 were identified in the literature review and 48 by expert panelists. We determined that adjustment for 50 covariates may be required to estimate the long-term effects of knee OA treatments on pain.
CONCLUSION: We present a process for combining literature reviews with expert input to synthesize existing knowledge and improve covariate selection. We apply this process to the long-term follow-up of a randomized trial and show that expert input provides additional information not obtainable from literature reviews alone.
Subjects will receive the Sedline sensor. The anesthesiologist will be blinded to the PSI Rev 1.X score and the raw EEG data from the Masimo device. Anesthesia management will be in accordance with standard of care protocols and procedures.
FIELD: microbiology. SUBSTANCE: strain is obtained by breeding strains YF-135 and 5D-P3016. For producing cellular mass of the strain-producer HBs Ag two-stage of culturing schedule is used. At the first stage cells are revived and biomass is accumulated. The strain Y-1678 has no the latent phase of the growth and cells begin to divide immediately after sowing. Double time of cells is 1.5 h and specific rate of the growth has a value μ = 0.48 h. The stationary phase of the growth occurs after 8-10 h at maximal yield of cells 2.4 x 10 -8  cells/ml while in the process of culturing the known strains the synthesis stage HBs Ag has significant time. The use of the proposed strain ensures to decrease culturing period an average by 10 h due to increase of cell amount and the more intensified synthesis of HBs Ag. Invention can be used for production of preparations for diagnosis and prophylaxis of hepatitis B. EFFECT: decreased consumption of energy, materials and labor intensity in culturing process. 1 tbl, 1 ex
OBJECTIVE: To evaluate the adapted version of West Haven-Yale Multidimensional Pain Inventory for patients with chronic pain.
METHODS: The multiphase study was conducted from January to December 2021. The factorial structure of the Urdu version of West Haven-Yale Multidimensional Pain Inventory was evaluated on a sample of adult patients aged 18- 45 years with non-specific chronic pain, taken from public and private hospitals and clinics of Lahore, Pakistan. The Urdu version was then subjected to factor analysis, while Cronbach's alpha, composite reliability, convergent and discriminant validity of the scale were also calculated. Data was analysed using SPSS 24.
RESULTS: Of the 306 subjects, 204(66.7%) were females and 102(33.3%) were men. The overall mean age was 30.94+/-8.44 years. There were 166(54.2%) subjects who were married, and 137(44.8%) reported experiencing pain daily. The confirmatory factor analysis showed a 45-item structure for 12 sub-scales as the best fit. The statistics for the final model were observed as minimum discrepancy function by degrees of freedom divided was 1.69, root mean square error of approximation was 0.05, and standardised root mean square residual was 0.06. Comparative fit index value was 0.91 and Tucker-Lewis coefficient was 0.90. Cronbach's alpha reliability ranged between 0.68 and 0.89 for the subscales, while for the total scale, it was 0.72.
CONCLUSION: The Urdu version of West Haven-Yale Multidimensional Pain Inventory was found to be a reliable and valid tool for chronic pain assessment for patients in Pakistan.
Methods and systems for risk assessment and adjustment are described. In one embodiment, a patient-level risk score associated with a patient is calculated. A plan-level average risk score associated with a benefit plan is calculated. The patient is a member of the benefit plan. A missing diagnosis code associated with the patient is identified based on medical claims history of the patient, historical prescription drug claims of the patient, and a drug marker. A revised patient-score associated with the patient is calculated based on identification of the missing diagnosis code. Additional methods and systems are disclosed.
To evaluate the efficacy of ultrasound-guided intercostal nerve block in managing pain and physiological responses in patients undergoing radical mastectomy for breast cancer. A retrospective study analyzed 120 patients scheduled to undergo radical mastectomy in our hospital between January 2022 and December 2023. Depending on the type of anesthesia received, participants were assigned to the experimental group (60 patients) to receive ultrasound-guided intercostal nerve block and intravenous general anesthesia, or the control group (60 patients) to receive intravenous general anesthesia only. Both groups will utilize patient-controlled intravenous analgesia (PCIA) postoperatively. We will monitor and compare hemodynamic parameters, SpO2, and bispectral index (BIS) at multiple time points, and assess postoperative pain, inflammatory markers, PCIA utilization, and adverse reaction incidence. Comparative analysis showed distinct trends in heart rate, mean arterial pressure (MAP), BIS, and SpO2 across various surgical stages between groups. Notably, MAP values were consistently higher and less variable in the experimental group during surgery (P < .05). Pain assessments at 4, 12, and 24 hours postoperatively in both quiet and coughing states revealed significantly milder pain in the experimental group (P < .05). Preoperative inflammatory markers (PGE2, TNF-α, IL-6, MCP-1) were similar between groups; however, 24 hours post-surgery, the experimental group showed significantly lower levels of PGE2, IL-6, and MCP-1 (P < .05). Sufentanil consumption during surgery and PCIA use were notably lower in the experimental group (P < .05). The experimental group also experienced fewer anesthesia-related adverse reactions (8.33%) compared to the control group (25.00%) (P < .05). Ultrasound-guided intercostal nerve block significantly improves hemodynamic stability, reduces postoperative inflammatory markers, lowers the need for sufentanil, and minimizes adverse reactions in patients undergoing radical mastectomy for breast cancer.
Stem cells (sc) are the foundation cells for every organ, tissue and cell in the body. They are self sustaining and can replicate themselves for long periods of time. They have the remarkable potential to develop in many different cell types in the body. Premature ovarian failure (POF) is the loss of ovarian function in women less than 40 years. It is associated with sex steroid deficiency, amenorrhea, infertility, and elevated serum gonadotropins. This work aimed to evaluate the therapeutic potential of Autologous Mesenchymal sc (MSC) transplantation in women suffering from POF. Out of 112 high risk patients for POF, 10 cases were diagnosed as POF. The ten POF patients were scheduled for MSC transplantation at Al- Azhar University Hospitals. MSC preparation from the bone marrow of the iliac crest was laparoscopically injected in the ovaries. Endometrial fractional biopsy is histopathologically (HP) and Immunohistochemically (IH) stained and evaluated according to Edessy stem cells score (ESS) (1).
Temozolomide Capsules: In clinical trials, temozolomide capsules were administered under both fasting and nonfasting conditions; however, absorption is affected by food [see Clinical Pharmacology (12.3)], and consistency of administration with respect to food is recommended. There are no dietary restrictions with temozolomide capsules. To reduce nausea and vomiting, temozolomide capsules should be taken on an empty stomach. Bedtime administration may be advised. Antiemetic therapy may be administered prior to and/or following administration of temozolomide capsules. 

Temozolomide capsules should not be opened or chewed. They should be swallowed whole with a glass of water.

If capsules are accidentally opened or damaged, precautions should be taken to avoid inhalation or contact with the skin or mucous membranes [see How Supplied/Storage and Handling (16.1)].
Orthognathic surgery may induce hemorrhage resulting from nasal mucosal injury or from maxillary osteotomy sites, and if severe, the hemorrhage may cause airway obstruction. The patient in this case report was a 27-year-old woman who underwent Le Fort I and bilateral sagittal split osteotomies under general anesthesia. There were no abnormal intraoperative vital signs. However, immediately after the patient was returned to the ward, significant bleeding that required frequent suctioning was observed in the oral cavity. As the bleeding persisted, the surgeon attempted to insert epinephrine-soaked gauze and polyvinyl acetal sponges into both nasal cavities, but hemostasis was difficult to obtain. To achieve hemostasis by compression/closure at the choana and maintain nasal patency, we inserted a modified cuffed endotracheal tube to serve as a transnasal airway and a choanal hemostatic balloon. This method resulted in hemostasis. The volume of blood loss after returning to the ward was approximately 420 mL. The transnasal airway and choanal balloon was useful for airway management and the prevention of intranasal bleeding into the lower pharyngeal regions. Furthermore, the method was simple and minimally invasive, suggesting its clinical usefulness in similar situations.
As a member of the p53-binding protein family, apoptosis-stimulating protein p53 2 (ASPP2) is closely related to autophagy and apoptosis. However, the mechanistic role of ASPP2 in the development of metabolic dysfunction-associated steatohepatitis (MASH) remains elusive. Therefore, we investigated the role and underlying mechanisms of ASPP2 in MASH progression in a mouse model of MASH and a cellular model of metabolic dysfunction-associated fatty liver disease. ASPP2 deficiency significantly promoted the inflammatory response, steatosis, and MASH progression in mice. Through transcriptomic analysis, increased ACSL4 expression was identified as a potential key factor. Further elucidation of the underlying mechanisms demonstrated that ASPP2 deficiency increased lipid accumulation and inhibited mitochondrial respiration capacity in HepG2 cells induced by oleic acid. However, silencing of ACSL4 reversed these effects. Thus, our study indicates that ASPP2 is an important regulator of MASH progression through ACSL4 upregulation, highlighting its potential as an alternative approach to MASH treatment.
<P>PROBLEM TO BE SOLVED: To solve problems in conventional art that it is necessary to compound a large amount of a propellant in order to uniformize a separated stock solution and safety for fire is low because a combustible liquefied gas such as liquefied petroleum gas or dimethyl ether is used as the propellant.  <P>SOLUTION: The aerosol composition comprises a nonuniform liquid composition comprising two or more kinds of components which are liquids in an airtight container compounded therein and gaseous carbon dioxide. The aerosol composition is uniformized by pressurizing and dissolving the gaseous carbon dioxide in the liquid composition. An aerosol product is prepared by filling the aerosol composition in the airtight container. Water, the liquefied gas, or the like, can be contained in the liquid composition. The aerosol product preferably has 2-5 MPa product pressure at 25°C.  <P>COPYRIGHT: (C)2004,JPO
The present invention provides a compound for the sequestration of undesirable neutralizing antibodies against viral vectors (as used in vaccines and in gene therapy) in a patient. The compound comprises an inert biopolymer scaffold and at least a first peptide n-mer of the general formula P ( ? S ? P )(n-1) and a second peptide n-mer of the general formula P ( ? S ? P )(n-1); wherein, independently for each occurrence, P is a peptide with a sequence length of 2-13 amino acids and S is a non-peptide spacer, wherein, independently for each of the peptide n-mers, n is an integer of at least 1, wherein each of the peptide n-mers is bound to the biopolymer scaffold. Independently for each occurrence, P has an amino-acid sequence comprising a sequence fragment with a length of at least six amino acids of a capsid protein sequence of a viral vector. Also provided are pharmaceutical compositions comprising the compound, as well as a method of sequestering one or more antibodies present in an individual and a method of inhibiting an undesirable immune reaction to a treatment with a vaccine or a gene therapy composition.
The invention discloses a medicament for eliminating turbid urines and activating blood stasis, which comprises the following compositions in part by weight: 10 to 20 parts of fried atraotydin, 10 to 20 parts of fried amur corktree bark, 5 to 10 parts of prepared rhubarbs, 5 to 10 parts of prepared tablets, 10 to 20 parts of giant knot weeds, and 15 to 20 parts of suberect spatholobus stems. In the invention, the fried atraotydin and the fried amur corktree bark have the effects of clearing heat and promoting diuresis; the prepared rhubarbs and the prepared tablets have the effects of clearing heat and warming kidney, and purgating fu-organs and eliminating turbid urines; and the giant knot weeds and the suberect spatholobus stems have the effects of activating blood stasis and activating collaterals; therefore, the c of the invention has the effects of promoting diuresis and eliminating turbid urines, reducing blood uric acid, clearing heat and activating collaterals, treating urarthritis, and warming kidney and eliminating turbid urines, and treating chronic renal insufficiency, is less in side effect and definite in curative effect. The clinical observation results (setting control groups) show that the invention can improve the clinical symptoms obviously. The symptom scores of a treatment group before and after integration have an obvious difference P (0.01). The medicine of the invention has the effects of reducing uric acid and inflammatory markers as well as triglycerides and improving renal function. The total effective rate of the medicine is 87 percent, which is better than that of the control group (the total effective rate is 60 percent, P: 0.05). The medicine has no obvious side effect.
Participants: 100 patients who underwent elective gynecologic laparoscopic surgery Methods: We recruited 100 patients who are planned for gynecologic laparoscopic surgery. Patients were enrolled from March 1, 2015. We randomly allocated patients into two groups: controlled group ( patients treated without transcutaneous electrical acupoint stimulation) and TEAS group (patients treated with TEAS on Feishu, Hegu, Chize half an hour before the surgery). Blood pH, Pco2, Po2 and oxygen saturation were measured by an automatic blood gas analyzer immediately after obtaining the samples from the aorta. Sample all the patients blood before and after the surgery. And then measure the level of TNF-α, IL-1β, and IL-6.