anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the conventional injection technique, painful local swelling of the tissues at the injection site occurs during the administration of local anesthetics. Failure to control the rate of administration of anesthesia increases pain, swelling and tissue tension, leading to the discomfort and unpleasant sensations that accompany local anesthesia. In addition, an uncontrolled and shocking increase in pressure in the anesthetized tissues can lead to short-term blood supply disturbances and local damage, reducing the effectiveness of anesthesia and increasing the risk of side effects. It has been reported that the pain felt during anesthesia is mostly caused by the inability to control the pressure generated during the injection of the solution. To overcome these shortcomings, the search for new alternative and minimally invasive methods of local anesthesia has been in the limelight with better pain control, reduced injection pain and improved quality of treatment for pedodontic procedures. With the use of computer-assisted local anesthesia systems, the anesthetic solution is administered gradually and the tissue pressure during anesthesia can be controlled. Thus, a less painful and more comfortable anesthesia experience can be provided. SleeperOne® 5, one of the computer-assisted local anesthesia systems, is a device with advantages such as ease of use, less intimidating physical appearance of the needle, no need for pressure during injection, guided entry points to the injection site. There are no previous studies comparing the use of intraosseous technique with SleeperOne® 5 device and conventional mandibular anesthesia in mandibular permanent molars. In this study, the investigators aimed to compare the pain and anxiety caused by the SleeperOne® 5 anesthesia system in children compared to traditional anesthesia methods, of which there are few studies in the literature. The first null hypothesis (H0) of the study is that there is no difference between intraosseous anesthesia administered with SleeperOne® 5 computer-assisted anesthesia systems and buccal infiltration and mandibular anesthesia administered with conventional methods in terms of anxiety in patients. The second null hypothesis of the study is that there is no difference between intraosseous anesthesia performed with SleeperOne® 5 computer-assisted anesthesia systems and buccal infiltration and mandibular anesthesia performed with conventional methods in terms of pain.
BACKGROUND AND AIMS: Few studies have examined the relationship between daytime napping and risk of kidney diseases. We aimed to investigate the association of daytime napping with the incidence of chronic kidney disease (CKD) and end-stage kidney disease (ESKD). We also examined whether sleep duration modified the association of nap with CKD or ESKD.
METHODS: We recruited 460,571 European middle- to older-aged adults without prior CKD or ESKD between March 13, 2006, and October 1, 2010, in the UK Biobank. Sleep behavior data were obtained through questionnaires administered during recruitment. The analysis of the relationship between napping and the occurrence of CKD and ESKD utilized Cox proportional hazards regression models. The modification role of sleep duration on the effect of nap on CKD and ESKD was also examined.
RESULTS: After a mean follow-up of 11.1 (standard deviation 2.2) years, we observed 28,330 incident CKD cases and 927 ESKD cases. The daytime napping was associated with incident CKD (P for trend = .004). After fully adjusted, when compared with participants who did not take nap, those in sometimes and usually nap groups had higher risk of CKD. Nevertheless, the available evidence did not support a link between daytime napping and ESKD (P for trend = .06). Simultaneously, there was insufficient evidence suggesting that sleeping duration modified the association of daytime napping with incident CKD or ESKD.
CONCLUSION: Daytime napping was associated with an increased risk of CKD. However, the absence of conclusive evidence did not indicate a connection between daytime napping and ESKD.
The human papillomavirus (HPV) belongs to the Papillomaviridae family of viruses which includes small, double-stranded DNA viral agents. Approximately 90% of HPV infections occur asymptomatically and resolve spontaneously. However, infection with high-risk viral strains can lead to the development of preneoplastic lesions, with an increased propensity to become cancerous. The location of these malignancies includes the oral cavity, cervix, vagina, anus, and vulva, among others. The role of HPV in carcinogenesis has already been demonstrated for the aforementioned neoplasia. However, regarding skin malignancies, the mechanisms that pinpoint the role played by HPV in their initiation and progression still elude our sight. Until now, the only fully understood mechanism of viral cutaneous oncogenesis is that of human herpes virus 8 infection in Kaposi sarcoma. In the case of HPV infection, however, most data focus on the role that beta strains exhibit in the oncogenesis of cutaneous squamous cell carcinoma (cSCC), along with ultraviolet radiation (UVR) and other environmental or genetic factors. However, recent epidemiological investigations have highlighted that HPV could also trigger the onset of other non-melanocytic, for example, basal cell carcinoma (BCC), and/or melanocytic skin cancers, for example, melanoma. Herein, we provide an overview of the role played by HPV in benign and malignant skin lesions with a particular focus on the main epidemiological, pathophysiological, and molecular aspects delineating the involvement of HPV in skin cancers.
MHC class II-restricted  Chlamydia -specific CD4 T cell clones recognize infected upper reproductive tract epithelial cells as early as 12 hours post infection. The timing and degree of T cell activation are dependent on the interferon milieu. Different interferons have different effects on T-cell activation; interferon IFN-β blunts IFN-γ induced up regulation of epithelial cell surface MHC class II and T cell activation. A subset of CD4 T-cells that was especially good at clearing  Chlamydia  infections from the genital tracts of infected mice was found to express the genes Casd1 and Plac8. The mouse Casd1 genes shares some 95 percent identity with the human gene. The differential expression of either Plac8 or Casd1 in COD cells in response to an infection of epithelial tissue provides a ready methodology for the identification of individuals exposed to epithelial infections and a tool for developing vaccines against pathogens that infect epithelial tissue.
The invention discloses a bandage for treating the snake-head furuncle. The bandage comprises a winding band (1). A piece of gauze (2) is connected to one end of the winding band (1) in a sewing mode. The other end of the winding band (1) is provided with a piece of adhesive cloth (4). The three inner lateral sides of the gauze (2) are each provided with a cataplasm slice (3) used for adhering to the winding band (1). The bandage is characterized in that a medicine slurry block formed by smashing fresh seeds of rhizoma pinelliae, fresh rhizoma paridis, and fresh stinky radix aucklandiae roots according to the ratio of 5:3:2 is arranged between the gauze (2) and the winding band (1). In order to treat the snake-head furuncle, the preparation method includes the steps that the medicine slurry block with functions of removing toxic materials and stasis, relieving swelling and pain, and dredging meridians and removing toxin is built in the portion, below the gauze (2), of the winding band (1) and is then used in cooperation with realgar alcohol with functions of removing toxin and killing insects and introducing medicine into meridians for acting on affected parts, the medicine effect directly acts on a focus, the functions of removing heat toxin, removing swelling, making tissue of the affected parts white and wrinkled and eliminating inflammation are achieved, and therefore the effect of rapidly treating the snake-head furuncle is achieved. The bandage has the advantages of being low in manufacturing cost, good in use effect and capable of greatly shortening treatment time.
PURPOSE: Health supplement food containing a processed panax species plant extract as an active component is provided to protect liver cells, or improve and prevent liver diseases. CONSTITUTION: Health supplement food for the protection of liver and the improvement or prevention of liver diseases contains a panax species plant extract in which medicinal components are increased and the sum of ginsenoside Rg3, Rk1, Rg5 contents is higher than the sum of ginsenoside Rb1, Rb2, Rc, Rd contents. The panax species plant is processed ginseng in which medicinal components are increased to obtain the ratio of ginsenoside(Rg3+Rg5)/(Rc+Rd+Rb1+Rb2) to be more than 1.0., and the ginseng is heated for 0.5 to 20 hours in high temperature of 120-180 deg. C. The extracts use water, low grade alcohol including methanol, ethanol, butanol, or a mixed solvent thereof. The liver disease is acute hepatitis and chronic hepatitis, fatty liver, hepatocrrihosis, hepatic fibrosis, and liver cancer. The form of the health supplement food is powder, granules, tablets, capsules, or beverages. [Reference numerals] (AA) Cell survival rate(%); (BB) Do not add t-BHP; (CC) Add t-BHP
This approach consisted of a 15-minute session in which the dentist attempted to impart knowledge about oral hygiene in general, highlighting some of the most common situations in this age group, namely the difficulty in achieving correct brushing and flossing, demonstrating the correct technique on a typodont (model), and alerting them to the importance of oral health to general health. Periodontal disease, tooth decay and denture care were also covered in general terms. Participants were given a written explanatory guide to reinforce good oral hygiene habits and an explanation of these diseases or conditions. Appropriate oral hygiene tools were also provided to encourage the expected improvement in oral health. Finally, there was a question-and-answer session to clarify any doubts the participant might have.
Metoprolol (12.5-25 mg per dose, every 12 hours) was initially given from the day of CRS diagnosis confirmation post CAR T cell infusions till CRS remission in patients without bulky tumor burden. For all metoprolol-treated patients, the use of antibodies (infliximab, etanercept and tocilizumab) and/or other agents were not completely limited under the consideration of clinical requirement for sufficient control of continuously progressed CRS.
PROBLEM TO BE SOLVED: To monitor the moving conditions of the owner of a radio communication type storage medium and to reduce the burdens of a doctor and a nurse, etc., by making the radio communication type storage medium which performs reception transmit identification data intrinsic to the medium by a radio transmission-reception means when transmission request signals are transmitted by radio waves. SOLUTION: A patient possesses a radio card 2. Then, when a reader-writer 4 transmits the transmission request signals by the radio waves, the radio card 2 which receives the transmission request signals transmits ID signals intrinsic to the radio card 2. Based on the ID signals, the position of the patient possessing the radio card 2 or the like is detected. That is, for instance, the reader-writer 4 of an A base 3a changes the directivity of an antenna 40 and defines the position where the reception electric field strength of position signals from the radio card 2 becomes maximum as the position of the radio card 2. Then, communication is performed with the radio card 2 for plural times, the position of the radio card 2 is detected and position information such as a moving direction and a moving speed, etc., is detected.
Critically ill patients with acute lung injury and acute respiratory distress syndrome (ALI/ARDS) who receive mechanical ventilation can suffer from severe sleep disruption despite continuous sedative infusions. Sleep disruption, in turn, may activate the sympathetic nervous system and cause elevation of circulating inflammatory cytokines, which, in turn, may play a causative role in delirium and post-traumatic stress disorder through consolidation of unpleasant memories during awakenings from sleep. Currently, there is very little understanding of the inter-relationship between critical illness, sleep, and neuropsychological well-being, due to the lack of intervention-based trials that improve sleep during critical illness. The central purpose of this proposal is to study the short-term effects of sedation with sympatholysis (central α2 adrenergic agent) on sleep and inflammation in critically ill patients with ALI/ARDS. Sedation with sympatholysis will be achieved by a novel sleep-promoting agent with central α2 adrenergic properties. This FDA approved novel sedative agent, dexmedetomidine, has been shown to decrease delirium (an independent predictor of mortality) and decrease duration of mechanical ventilation and ICU stay in critically ill patients receiving mechanical ventilation (Riker et al, JAMA 2009;301:542-44 and Pandharipande et al, JAMA 2007;298:2644-53). We will undertake sleep studies and measure circulating inflammatory cytokines that modulate sleep in patients with ALI/ARDS randomized to receive two different sedation strategies: central α2 adrenergic sedative-analgesic (dexmedetomidine) versus a conventional sedation strategy (midazolam and fentanyl) in a randomized, double blind, cross-over study. Specific Aim 1: To assess the short-term effect of an α2 adrenergic agent on sleep quality in critically ill patients with ALI/ARDS. Specific Aim 2: To assess the short-term effect of an α2 adrenergic agent on sleep-modulating inflammatory cytokines in critically ill patients with ALI/ARDS. Specific aim 3: To determine the effect of α2 adrenergic agent on the in-vitro production of sleep-modulating inflammatory cytokines by peripheral blood mononuclear cells of patients with ALI/ARDS. Collectively, our study will identify whether sleep disruption in such patients can be minimized. In the long-term, this program of research will identify sedation practices that are least associated with adverse short- and long-term consequences of critical illness, and thereby ultimately help improve quality of life of patients surviving critical illness
The invention relates to a preparation method of a traditional Chinese medicine for treating lumbago type acute glomerulonephritis, belonging to the technical field of preparation methods of traditional Chinese medicines. At present, penicillin is generally adopted for treating lumbago type acute glomerulonephritis, but penicillin can easily cause allergic reaction, especially allergic shock. The technical scheme adopted in the invention is as follows: taking morinda officinalis, black-bone chicken, arillus longan, rhizoma curculiginis, cistanche, actinolite, eucommia ulmoides, flastem milk vetch seed, fructus psoraleae, polyporus lucidus, holly leaves, rhizoma drynariae, mulberry, parasitic loranthus, semen cuscutae, herba epimedii, teasel root, semen sesami nigrum, cynomorium songaricum, prepared rehmannia root, polygonum multiflorum, angelica sinensis, radix paeoniae alba, longan pulp, fenugreek, walnut kernel, testiest penis phocae and liquorice, soaking the 28 kinds of traditional Chinese medicines in water, and decocting with slow fire, wherein the decocted liquid medicine is the traditional Chinese medicine for treating lumbago type acute glomerulonephritis. The traditional Chinese medicine for treating lumbago type acute glomerulonephritis has the advantages of short course of treatment and high cure rate. Assistant and guide are achieved so that the function is just right. When the traditional Chinese medicine treating lumbago type acute glomerulonephritis is applied, adverse reaction, allergic reaction and toxic reaction caused by Western medicine are avoided.
This single center clinical pilot study will investigate the effects of niacin on blood lipids and lipoprotein composition in human subjects who are healthy. Niacin (vitamin B3 or nicotinic acid) is a common nutrient found in many foods and is currently sold over the counter as a nutritional supplement. Extended-release versions of niacin are available over the counter (e.g., Slo-Niacin) or by prescription (Niaspan) and help to alleviate symptoms of flushing associated with larger doses of the vitamin. Studies of the effects of niacin therapy on clinical lipid measures consistently indicate a shift toward a healthier lipoprotein profile with increased HDL-C and decreases in both triglyceride and LDL-C. Despite this favorable shift in lipid profile, cardiovascular outcome studies on patients receiving niacin alone or in combination with statin therapy have resulted in mixed results creating uncertainty of the value of niacin therapy. The proposed study will examine in detail the effects of niacin therapy on lipoprotein composition and function, while also tracking measures of vascular health.
SCID screening: more drops of blood are placed on a second Guthrie card when current screening (72 hours of life ) is performed after parents' information and consent. The card drawn for the protocol will follow the usual network except that the test for quantifying TRECs will be realized to determine the presence of SCID.
FIELD: food and chemical-pharmaceutical industry. SUBSTANCE: addition has 88-92 wt.% of dihydroquercetin and 8-12 wt.% of dihydrokaempferol. Addition is prepared by extraction of larch milled wood with water at heating followed by cooling, filtration, evaporation of extract and its dissolving in organic solvent. Then the end product is purified by column chromatography on silica gel and product is eluted by an aqueous-spirituous solution. Product is evaporated and crystallized from the solution. Prepared biologically active addition is both effective as food addition and provides effective prophylaxis of many diseases and enhances human body defense system. EFFECT: enhanced effectiveness of addition, improved method of preparing. 3 cl, 3 ex
NEW MATERIAL:A compound expressed by formula I (ring A is benzopyran ring, tetrahydroquinoline ring or indoline ring; which may have a substituent group; R is phenyl or pyridyl which may have a substituent group; n is 0 or 1 or an acid addition salt thereof. EXAMPLE:2-[(3-Methyl-2-pyridyl)methylthio]pyrano[3,2-e]benzimidazole. USE:An antiulcer agent, analgesic agent and anti-inflammatory agent. PREPARATION:A compound expressed by formula II is reacted with a compound expressed by formula III (X is halogen) in the presence of a base, e.g. NaHCO3, NaOH or pyridine, in a solvent, e.g. benzene, methanol, DMF or waster, at 60-110 deg.C for 20min-6hr to afford the aimed compound expressed by formula I etc.
Patients with RA treated with prednisolone, minimum 5 mg/day for minimum 6 months. Patients are grouped according to haplotype of 4 SNPs of the glucocorticoid recepror gene. Patients with or without these polymorphisms were invited to a Synacthen® test, but patients with a mixed hetero- and homozygote genotype were not. Adrenal function is evaluated with a Synacthen test.
The invention relates to a medicament for curing sugar diabetes and the manufacture method. It is made up from 20-50g root bark of barbary wolf berry, 10-20g kychee pit, 10-20g Chinese clematis, 10-20g treasure-tripod incense, 10-20g achene of creat burdock, 30-60g winged euony twigs, 10-30g bitter balloonflower. It has multifunction of descending blood sugar, balancing viscera, adjusting yin yang, enhancing immunity, repairing pancreatic islet, etc. The total efficiency reaches 100%. In 15 days, kinds of symptoms caused by sugar diabetes would be ameliorated, for most patients in 30 days the index would be controlled in normal range. After the second treatment period, patients do not need to continue using the medicament.
Participants in this arm will smoke electronic cigarettes for two weeks. E-cigarettes (either JUUL or Vuse Alto) and pods (JUUL: Virginia tobacco flavor at 3% or 5% nicotine concentration; Vuse Alto: golden tobacco flavor at 1.8%, 2.4%, or 5% nicotine concentration) will be provided.
The invention discloses a kind of preparation method of SHENGMAI YIN KOUFUYE, it is characterised in that described oral liquid preparation process includes：1. ginseng, the tuber of dwarf lilyturf, Fructus Schisandrae Chinensis powder are broken into meal, it is standby；2. above-mentioned meal 50-70% ethanol as solvent, diacolation is carried out after dipping 24h, collects percolate, be concentrated under reduced pressure after letting cool carries out an alcohol precipitation to concentrate again, and amount of alcohol is 50-70%, 20-30 DEG C of temperature during alcohol precipitation, time 24-48h, after precipitation solution is concentrated afterwards, enters the heavy filtration of water-filling；3. coarse filtration, sugaring slurry and appropriate preservative are carried out with miillpore filter, pH value is surveyed and is supplied liquid full dose；4. it is 4.5-7.0 to adjust pH value with NaOH, filling with the direct suction filtration of filter membrane respectively；5. got product after sterilizing.The oral liquor increased an alcohol precipitation, precipitation goes unnecessary impurity and the tannin not eliminated, and use steam sterilization, liquid clarity and stability are all improved, the method has simple to operate, favorable reproducibility, the advantages of effect is obvious, is adapted to industrialized production, with certain application prospect and market value.
PURPOSE: Cervical disc arthroplasty (CDA) is widely employed for patients diagnosed with cervical degenerative disc disease (CDDD). Postoperative bone loss (BL) represents a radiological alteration that is a relatively novel consideration in the realm of CDA. This study endeavors to examine the risk factors associated with BL following CDA, aiming to elucidate the underlying mechanisms and the impact of BL on surgical outcomes.
METHODS: A retrospective study was undertaken, encompassing consecutive patients subjected to one-level CDA, two-level CDA, or two-level hybrid surgery (HS) for the treatment of CDDD at our institution. Patient demographic and perioperative data were systematically recorded. Radiological images obtained preoperatively, at 1-week post-operation, and during the last follow-up were collected and evaluated, following with statistical analyses.
RESULTS: A total of 295 patients and 351 arthroplasty segments were involved in this study. Univariate logistic regressions indicated that age ≥ 45 years and two-level HS was associated with lower risk of BL; and a greater ΔDA (change of disc angle before and after surgery) was correlated with an increased risk of BL. Multivariate logistic regression determined that two-level HS and greater ΔDA were independent preventative and risk factors for BL, respectively. Further analysis revealed that severe BL significantly elevated the risk of implant subsidence compared to non-BL and mild BL.
CONCLUSIONS: This study posited bone remodeling and micromotion as potential underlying mechanisms of BL. Subsequent research endeavors should delve into the divergent mechanisms and progression observed between lower- and higher-grade BL, aiming to prevent potential adverse outcomes associated with severe BL.