anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a plant bacteriostatic preparation for treating burns and scalds and a preparation method thereof, belonging to the technical field of medicines. The antibacterial preparation is prepared from sanguis Draxonis with effects of promoting blood circulation, relieving pain, healing sore, and promoting granulation; lignum sappan with effects of promoting blood circulation, healing wound, removing blood stasis and dredging channels; caulis Spatholobi is effective in promoting blood circulation and replenishing blood; fructus Rosae Laevigatae has effects of consolidating semen, reducing urination, and stopping leukorrhagia; the leech breaks blood and promotes menstruation, and removes stasis and eliminates abdominal mass; rhizoma Polygoni Cuspidati has blood stasis dispelling and pain relieving effects; the cowherb seed promotes blood circulation and dredges the channels, and promotes urination and drenches; rhizoma Bletillae has astringent, hemostatic, repercussive, and granulation promoting effects; herba Ecliptae has effects of cooling blood, stopping bleeding, eliminating dampness, and relieving itching; the frankincense has the effects of detumescence and granulation promotion; galla Turcica can heal wound. The preparation has strong antibacterial effect on Escherichia coli and Staphylococcus aureus. The application range is as follows: bacteriostasis, cleaning and nursing. It also has antibacterial, antiinflammatory, and analgesic effects on scald, burn, chemical material burn, burn due to welding, firecracker explosion, and cigarette smoke. The preparation is prepared by the most original processing method, and is not only beneficial to the precipitation of the effective components, but also beneficial to the use of the medicine.
BACKGROUND: Non-hemolytic acute transfusion reactions (ATRs) are generally not fatal, but they can cause serious increases in workload and costs as a result of blood product wastage.
METHODS: A retrospective analysis was made of the data of the 7-year period between January 2016 and December 2022 to identify the possible associations between patient and product characteristics and the development of ATRs.
RESULTS: A total of 113,666 blood products were transfused during the study period. There were 146 ATRs with an estimated rate of 1.28 per 1000 blood products administered. The most common ATR was mild allergic reactions (n = 84, 57.6%). No statistically significant relationship was found in blood group distribution between patients who had and did not develop ATR (p = 0.797). Febrile Non-hemolytic Transfusion Reaction (FNHTR) was more common in patients receiving erythrocyte suspension (ES) transfusion, and Fresh Frozen Plasma (FFP) was mostly used in those with mild allergic reactions (p < 0.001). Patient age was determined as > 60 years in those who developed FNHTR or 'others,' and < 60 years in patients with mild allergic reactions (p = 0.046).
CONCLUSION: The results of the current study demonstrated that regardless of blood group, the probability of developing FNHTR is high when ES is transfused in elderly patients, and the probability of developing mild allergic reaction is high when FFP is used. While recognizing that ATRs are difficult to prevent, it can be emphasized that prediction and management may become easier if clinicians keep these possibilities in mind when making transfusion decisions.
Active control - All participants in the active control group will receive 'usual care', (twice a week for 6 weeks), which will consist of reassurance and psychoeducation via the bio-psycho-social model on understanding persistent symptoms, including advice on adaptive illness behaviours, such as gradually resuming premorbid activities and avoiding excessive rest and "all-or-nothing behaviour". Additionally, participants will be afforded weekly 20-minute supervised progressive sub-symptom aerobic exercise sessions at the KITE clinic under the supervision of study coordinator. They will be instructed to also perform daily 20-minutes of subsymptom aerobic exercise outside the supervised exercise sessions.
Post-mastectomy pain syndrome (PMPS), characterized by persistent pain lasting at least three months following mastectomy, affects 20-50% of breast surgery patients, lacking effective treatment options. A review was conducted utilizing EMBASE, MEDLINE, and all evidence-based medicine reviews to evaluate the effect of fat grafting as a treatment option for PMPS from database inception to 29 April 2023 (PROSPERO ID: CRD42023422627). Nine studies and 812 patients in total were included in the review. The overall mean change in visual analog scale (VAS) was -3.6 in 285 patients following fat grafting and 0.5 in 147 control group patients. There was a significant reduction in VAS from baseline in the fat grafting group compared to the control group, n = 395, mean difference = -2.17 (95% CI, -2.95 to -1.39). This significant improvement was also noted in patients who underwent mastectomy without reconstruction. Common complications related to fat grafting include capsular contracture, seroma, hematoma, and infection. Surgeons should consider fat grafting as a treatment option for PMPS. However, future research is needed to substantiate this evidence and to identify timing, volume of fat grafting, and which patient cohort will benefit the most.
Knee osteoarthritis (OA) is a chronic degenerative joint disease that causes pain and adversely affects functional status and holistic well-being. This randomized controlled trial investigated the effect of Reiki on pain, functional status, and holistic well-being in patients with knee OA. The sample consisted of 42 patients. The control group received standardized treatment only, whereas the intervention group received face-to-face Reiki (nine positions; 39 minutes) and distance Reiki on two consecutive days in addition to standardized treatment. The Reiki group had lower pain scores than the control group as measured by the Visual Analog Scale (p < .001) and the Western Ontario and McMaster Universities Arthritis Index pain score (p < .001). Those participating in the Reiki group had improved holistic well-being scores specifically for the subscales of Sadness, Perception of Sadness, Spiritual Disruption, Cognitive Awareness, and General mood. Reiki is a safe, noninvasive, and cost-effective alternative treatment technique that has the potential to reduce symptoms of pain and improve holistic well-being in patients with knee OA.
PURPOSE:To obtain a cured article having excellent transparency without yellowing and discoloring in the oral cavity, by using N-cyclohexyl-5- ethylpyrimidinetrione as a polymerization initiator and an organometallic compound and organic halogen compound as a promoter. CONSTITUTION:(A) A polymerizable compound having at least one ethylenically unsaturated double bond (e.g. methyl methacrylate or ethylene glycol dimethacrylate) is cured by using (B) N-cyclohexyl-5-ethylpyrimidinetrione, (C) an organometallic compound selected from compounds, such as copper acetylacetonate, manganese naphthenate, lithium acetate and zinc acetylacetonate and (D) an organic halogen compound (e.g. dilauryldimethylammonium chloride). The amount of the respective components based on 100pts.wt. component (A) are 0.1-10pts.wt. component (B), 0.001-0.2pts.wt. component (C) and 0.1-5pts. wt. component (D). The resin is rapidly curable and exothermic temperature in polymerization is low. Thereby irritation in the oral cavity can be relieved.
The effects of acute exercise in heavy drinkers. Participants will cycle on ergometer for 30 min at 50-60% of Heart Rate Reserve (HRR).
Early diagnosis of Bell's palsy is crucial for effective patient management in primary care settings. This study aimed to develop a simplified diagnostic tool to enhance the accuracy of identifying Bell's palsy among patients with facial muscle weakness. Data from 240 patients were analyzed using seven potential clinical evaluation indicators. Two diagnostic benchmarks were established: one based on clinical assessment and the other incorporating magnetic resonance imaging (MRI) findings. A multivariate logistic regression model was developed based on these benchmarks, resulting in the construction of a predictive tool evaluated through latent class models. Both models retained four key clinical indicators: absence of forehead wrinkles, accumulation of food and saliva inside the mouth on the affected side, presence of vesicular rash in the ear or pharynx, and lack of pain or symptoms associated with tick exposure, rash, or joint pain. The first model demonstrated excellent discriminative ability (area under the curve [AUC] = 0.96, 95% confidence interval [CI] 0.94 - 0.99) and calibration (P < 0.001), while the second model also showed good performance (AUC = 0.88, 95% CI 0.83 - 0.92) and calibration (P = 0.005). Bootstrap validation indicated no significant overfitting. The latent class defined by the first model significantly aligned with the clinical diagnosis group, while the second model showed lower consistency.
Dupilumab 300 mg SC injection qw for 12 weeks added to background therapy of ICS/LABA (Fluticasone/Salmeterol combination therapy at stable dose for 4 weeks followed by Fluticasone monotherapy, dose progressively decreased and discontinued at Week 9). Albuterol or Levalbuterol was given as rescue medication.
A volunteer layperson (research subject), at least 16 years of age, will first receive 125ml of TLE injected subcutaneously into the left anterior thigh by a physician. Then the subject will self-inject a second 125ml of TLE into his/her right anterior thigh.
PURPOSE:To obtain a sebum-resistant powder which is excellent in capability of solidifying sebum and gives cosmetics with excellent sebum control effects and a good makeup retention by treating fine zinc oxide particles having a specified specific surface area with a specific polymer. CONSTITUTION:A sebum-resistant powder is obtd. by treating the surfaces of fine zinc oxide particles having a specific surface area of 15-100m<2>/g with a methylhydrogensiloxane-dimethylsiloxane copolymer represented by the formula [wherein m:n is (0.6:1)-(1.4:1), and m+n is 20-60]. The amt. of the copolymer used is pref. 1-20wt.% of the particles used. The surface treatment is done e.g. by mixing the particles with the copolymer and heating the mixture at 50-200 deg.C for 0.5-5hr. A solvent can be used if necessary at the mixing step.
Hemifacial spasm (HFS) is mainly caused by vascular compression on the roots of the VII cranial nerves from the brain stem. Microvascular decompression (MVD) is the exact surgical method for the treatment of HFS, but the incidence of dizziness and postoperative nausea and vomiting (PONV) after MVD is extremely high. Despite the use of dual antiemetic therapy during the operation, the incidence of PONV within 24 hours after MVD is still as high as 66.7%. Medication alone has limited effects on dizziness and PONV treatment after MVD. Meta-analysis shows that transcutaneous electrical acupoint stimulation (TEAS) is associated with the reduction of post-emetic remedies and the incidence of dizziness after general anesthesia, and it can be integrated into the multi-modal therapy of PONV. Therefore, the purpose of our study is to observe the prevention and treatment effect of TEAS on postoperative dizziness in patients with hemifacial spasm undergoing microvascular decompression surgery, and explore its possible mechanisms.
The invention discloses a compound traditional Chinese medicine moxa stick and a preparation method and application thereof, and belongs to the technical field of medicines. The compound traditional Chinese medicine moxa stick is prepared from the following raw materials in parts by weight: 0.5-1.5 parts of rhizoma atractylodis, 0.5-1.5 parts of coriander, 0.5-1.5 parts of asarum, 0.5-1.5 parts of frankincense, 0.5-1.5 parts of moxa and 0.5-1.5 parts of nard. The invention provides a preparation method: weighing the raw material powder according to the weight parts, uniformly mixing, and rolling into strips by using cotton paper to obtain the paper. The compound traditional Chinese medicine moxa stick provided by the invention is applied to the preparation of medicines with the effects of warming channels, dispelling cold, promoting qi and blood circulation and expelling cold and dampness; and the application in preparing air sterilizing products. The formula of the invention has scientific compatibility and reasonable proportion, and the medicinal materials have synergistic effect and can play the roles of warming channel, dispelling cold, promoting qi and blood circulation and expelling cold and dampness. The compound traditional Chinese medicine moxa stick provided by the invention also has the effects of resisting plague, sterilizing and disinfecting, and the effective inactivation rate of various bacteria reaches 99.96%.
The study will take place at Tel Aviv Sourasky medical center, otolaryngology outpatient clinic, a tertiary care academic hospital, for two years. It will be double-arm, open label, randomized controlled trial comparing two different methods of medical therapy following ESS. The allocation ratio is intended to be approximately equal for each arm. The two arms consisted of: a control arm (group A) of generic saline irrigation alone, irrigating with 20 mL per nostril tid for a total of 120 mL daily irrigation; and intervention arm (group B), which included generic N-Acetylcystine of 200 mg dissolved in 200 mL saline irrigated as per group A, 20 mL per nostril given tid daily (for a total of 120 mg). All medications will be used daily for the 3 months duration of the post-operative follow up. Patients will be instructed as to correct irrigation technique prior to discharge home from the hospital, and will be reminded of this technique at each postoperative clinic visit.
Epilepsy is characterized by hypersynchronous neuronal discharges, which are associated with an increased cerebral metabolic rate of oxygen and ATP demand. Uncontrolled seizure activity (status epilepticus) results in mitochondrial exhaustion and ATP depletion, which potentially generate energy mismatch and neuronal loss. Many cells can adapt to increased energy demand by increasing metabolic capacities. However, acute metabolic adaptation during epileptic activity and its relationship to chronic epilepsy remains poorly understood. We elicited seizure-like events (SLEs) in an in vitro model of status epilepticus for eight hours. Electrophysiological recording and tissue oxygen partial pressure recordings were performed. After eight hours of ongoing SLEs, we used proteomics-based kinetic modeling to evaluate changes in metabolic capacities. We compared our findings regarding acute metabolic adaptation to published proteomic and transcriptomic data from chronic epilepsy patients. Epileptic tissue acutely responded to uninterrupted SLEs by upregulating ATP production capacity. This was achieved by a coordinated increase in the abundance of proteins from the respiratory chain and oxidative phosphorylation system. In contrast, chronic epileptic tissue shows a 25-40% decrease in ATP production capacity. In summary, our study reveals that epilepsy leads to dynamic metabolic changes. Acute epileptic activity boosts ATP production, while chronic epilepsy reduces it significantly.
Teratogenic Effects. Pregnancy Category B: Reproduction studies have been performed in rats and mice at doses up to moderately maternally toxic dose concentrations (i.e., 200 mg/kg/day). These doses, based on a mg/m2 basis, are estimated to be 4 and 2 times, respectively, the human daily dose of 500 mg. In the animal studies, no evidence of harm to the fetus due to azithromycin was found. There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, azithromycin should be used during pregnancy only if clearly needed.

Nursing Mothers: It is not known whether azithromycin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when azithromycin is administered to a nursing woman.
Participants will receive active tDCS once daily for two weeks. The anode was placed over Fz with return electrodes placed at Fpz, Cz, F3 and F4. Fourteen 2-mA sessions (ramp-up and ramp-down periods of 30 and 30 seconds, respectively) were applied for 20 minutes each day over 14 consecutive sessions.
For the Phase I arm of the study the addition of planned numbers and ratios of Treg compared to Tcon will occur at defined time points after hematopoietic cell infusion. Each cohort will have 3 patients per group. The initial doses and ratios utilized will be 1 x 10\^6/kg of T reg cells to 3x10\^6/kg of Tcon cells at a 1:3 ratio. In order to progress to the next dose level, there must be no evidence of grade 3 or 4 acute GVHD.
BACKGROUND AND PURPOSE: Periprosthetic femoral fracture (PFF) is a significant complication of total hip arthroplasty (THA). Although biomechanical studies have indicated that the technique by which the femoral canal is prepared plays a role, few clinical studies have reported on how this might affect the fracture risk. This study compares the fracture risk between compaction and broaching with toothed instruments in cementless THA.
METHODS: Prospectively collected data from the quality register of a high-volume hospital was used. All primary arthroplasties using the Corail stem (DePuy Synthes) were included. All femoral fractures occurring within the first 90 days after the operation were included in the analysis. We determined the relative risk of sustaining PFF with compaction compared with broaching and adjusted for confounders (sex, age group, BMI, and use of a collared stem) using multivariable Poisson regression.
RESULTS: 6,788 primary THAs performed between November 2009 and May 2023 were available for analysis. 66% were women and the mean age was 65.0 years. 129 (1.9%) fractures occurred during the first 90 days after the operation, 92 (2.3%) in the compaction group and 37 (1.3%) in the broaching group. The unadjusted relative risk of fracture in the compaction group compared with the broaching group was 1.82 (95% confidence interval [CI] 1.25-2.66), whereas the adjusted relative risk was 1.70 (CI 1.10-2.70).
CONCLUSION: Compaction was associated with more periprosthetic fractures than broaching (2.3% versus 1.3%) within 90 days after surgery.
The GI is a method of classifying foods based on the food's ability to raise the blood glucose level. Low GI foods are recommended as they have a lower impact on blood glucose concentrations and also reduce total food intake. There is very little information on how eating high and low GI foods affect daily blood glucose concentrations in Asians. Therefore, the objective of this study is to observe the effect of eating high and low GI breakfasts and snacks on 24 hour blood glucose concentrations and food consumption in Asian males. Healthy, normal-weight, Chinese males will be recruited. There will be two sessions (consisting of four days for each session) where they will consume either a high or low GI breakfast or snack, and a standardized ad libitum lunch buffet. Their glycaemic response will be measured using a Continuous Glucose Monitoring System (CGMS) throughout the period. The proposed research for the first time demonstrates how the consumption of high and low GI breakfasts and snacks affect subsequent energy intake and 24 hour blood glucose profiles in Asians. These findings will have significant public health benefits for optimum weight and dietary control.
To explore the value of CT and MR using multiple sequences, including T2-TSE-BLADE, T2 maps StarVIBE, and iShim-DWI in evaluating the driving genes and prediction of response to therapy and OS in patients with lung cancer.

Patients with biopsy-proven lung cancer were prospectively enrolled for imaging on CT and a 3T MRI scanner . The MRI protocol included T2-TSE-BLADE, T2 maps,iShim-DWI and StarVIBE sequences, and so on. Patients received treatment according to NCCN( National Comprehensive Cancer Network) guideline. CT and MRI features were analyzed to find the correlation between pretreatment imaging features and driving genes and therapy response. The study will include 400 patients. Inter-reader agreements of TN staging were analyzed excellent for CT and MRI. Diagnostic accuracy of CT and MRI will be calculated separately.
No NG tube gastric decompression for orthognathic surgery. This group will not have a NG tube inserted. The remainder of their surgical care will be identical to the other group. PONV will be evaluated by nursing and surgical team at two time points in the 24 hour postoperative period (early \[0-2 hours\] and delayed \[2-24 hours\]).
The present disclosure describes systems and methods for predicting adverse health events of patients. In one embodiment, a system obtains a dataset including a plurality of values for each of a plurality of health measurements. The system can obtain the dataset in real-time or substantially real-time after a patient has taken the plurality of health measurements. The system can also obtain metadata about the dataset. The metadata may include a measure of the patient's adherence or non-adherence to a testing routine. The measure of non-adherence may indicate, for example, the quantity of days in a particular time period that the patient failed to conduct the testing routine. The system can apply an algorithm to the dataset and the metadata to generate a risk score. The risk score may indicate the likelihood that the subject will experience an adverse health event.
The present invention relates to the discovery, identification and characterization of an eight genes that are differentially expressed as a consequence of metastatic progression in human melanoma cells. Six of the identified metastasis elevated genes (MEG genes), encode for known proteins (MEG-1 through MEG-6). However, two of the identified genes, referred to herein as MEG-7 and MEG-8, represent novel genes. The present invention relates to methods for inhibiting the metastatic potential of cancer cells through inhibition of the MEG genes/gene products, as well as diagnostic methods for determining the metastatic potential of cells. The invention further relates to novel MEG-7 and MEG-8 nucleotides, host cell expression systems, MEG-7 and MEG-8 proteins, fusion proteins, and antibodies to the MEG-7 and MEG-8. The present invention also relates to the discovery that inhibition of the mda-9 gene (also referred to as syntenin), a gene found to be upregulated in metastatic cancer cells, results in a decrease in the invasive and migratory properties of such cells. Thus, the present invention relates also to methods and compositions for inhibiting mda-9/syntenin activity.
The present invention provides application of p-hydroxyl acetophenone glycosidase to medicine for autoimmunity disease and transplant rejection disease. Through experiments, p-hydroxyl acetophenone glycosidase is found to be capable of restraining multiplication of human dendritic cells in vitro, restraining human denderitic cells to promote breeder reaction of allogeneic T cells, and enhancing the ability of human denderitic cells to secrete interleukin 10. In a model of experimental autoimmunity disease cerebrospinal meningitis, p-hydroxyl acetophenone glycosidase is capable of reducing an average mouse clinical score and restraining spinal cord invasion degree of the mononuclear cells. In an experiment of heart transplantation, p-hydroxyl acetophenone glycosidase is capable of prolonging the survival time of the transplanted heart. In a model of delayed type hypersensitivity, p-hydroxyl acetophenone glycosidase is capable of reducing mouse ear swelling degree. According to the results both in vivo and in vitro, p-hydroxyl acetophenone glycosidase possesses a certain effect on autoimmunity disease and transplant rejection disease. The medicine provided by the invention comprises p-hydroxyl acetophenone glycosidase as an active component and a medicinal carrier, and the medicine includes oral dosage form, injection, suppository, and topical dosage form, etc.