anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The problem solving based intervention contains a problem solving process and cooperation between the person on sick leave, his/her employer and health care professionals. The intervention consists of five steps: 1) Making an inventory of problems and/or opportunities related to return to work; 2) brainstorming about solutions; 3) writing down solutions, identifying the support needed to implement the solutions; 4) a three-party meeting with the person on sick leave, his/her employer and the rehabilitation coordinator; 5) evaluation of the action plan and implementation of solutions, relapse prevention. The intervention takes the form of two to five consultations. The first and fourth steps are key elements.
PURPOSE: To obtain a composition for oral cavity having excellent low- temperature stability, stability after long-term preservation and a good feeling in use, containing an alkyl sulfate, an N-acylmethyltaurine salt and a polyethylene glycol. CONSTITUTION: 0.2-5wt.% of an alkyl sulfate (sodium lauryl sulfate) is blended with an N-acylmethyltaurine salt (e.g. sodium N-myristoylmethyltaurine) in the molar ratio of the alkyl sulfate/the N-acylmethyltaurine salt of 10:1 to 1:2 and 0.05-5wt.% of a polyethylene glycol having 200-6,000 degree of polymerization. The blend is properly mixed with other conventional components to give a composition for oral cavity such as toothpaste and can be prepared into a liquid composition for oral cavity such as a liquid dentifrice, an aqueous dentifrice or a mouth washing agent. The three main components synergistically act and the composition causes no grain and no wrinkles after low-temperature preservation and is neither gelatinized nor disproportionated when prepared as a liquid dentifrice having a low viscosity and preserved at low temperature. The composition for oral cavity has excellent low-temperature stability, excellent stability and foaming properties after long-term preservation and good flavor and an excellent feeling in use.
Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence. Understanding the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity. G protein-coupled receptors (GPCRs) are among the main modulators of metabolism and energy balance. They, for instance, regulate appetite and satiety in certain hypothalamic neurons, as well as glucose and lipid metabolism and hormone secretion from adipocytes. Mutations in some GPCRs, such as the melanocortin receptor type 4 (MC4R), have been associated with early-onset obesity. Here, we identified the adhesion GPCR latrophilin 1 (ADGRL1/LPHN1) as a member of the regulating network governing food intake and the maintenance of energy balance. Deficiency of the highly conserved receptor in mice results in increased food consumption and severe obesity, accompanied by dysregulation of glucose homeostasis. Consistently, we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from obesity. Therefore, we propose that LPHN1 dysfunction is a risk factor for obesity development.
Ixabepilone has a plasma concentration-dependent effect on tubulin dynamics in peripheral blood mononuclear cells that is observed as the formation of microtubule bundles.

Cardiac Electrophysiology

At the recommended dosage, IXEMPRA does not cause large mean increases (i.e., >20 msec) in the QT interval. The QT prolongation potential of ixabepilone was assessed as part of an uncontrolled, open-label, single-dose study in advanced cancer patients. Fourteen patients received a single dose of IXEMPRA 40 mg/m2 intravenously over 3 hours and serial ECGs were collected over 24 hours. The maximum mean ΔQTcF was observed 1 hour after the end of infusion and was 8 ms (upper 95% CI: 12 ms). No patients had a QTcF interval >450 ms or ΔQTcF >30 ms after IXEMPRA administration. However, small increases in QTc interval with the use of ixabepilone cannot be excluded due to study design limitations
The participant will follow on screen instruction for Sheetali/Sheetkari with shaped lips/mouth as indicated, fully filling and emptying the lungs with each breath. The tongue is allowed to protrude from the mouth at a comfortable distance and rolled into a tube. Following 10 minutes of Sheetali practice, participants will have a one-minute rest before continuing. In Sheetkari the teeth are exposed and the lips are kept apart for inhalation and the mouth is closed, tongue is relaxed, and exhalation occurs through the nose. Instruction will be displayed to them with on-screen video segments while the study personnel helps explains the steps, answers questions, and monitors adherence. There will be an auditory queue to prompt the participant to breathe in and out. Study personnel will monitor their posture and breathing rate and pause the recording if additional coaching is necessary.The total duration of this session will be approximately 40 minutes.
Patients were randomly assigned to preheated (36ᵒC, intervention) skin disinfection (Chlorhexidine 5mg/ml in 70% alcohol) or room temperature (20ᵒC, control) skin disinfection (Chlorhexidine 5mg/ml in 70% alcohol). Patient´s enrollment to operation was made by an external controller who had no closer knowledge of present study. All patients were asked to participate in that sequence they arrived to the OR department when study nurse was present. Assignment took place directly after patients consent. Patients were stratified into gender and thereafter randomly allocated to preheated or control group, based on a computer-generated randomization list made by an independent statistician. Patients showered, scrubbing their whole body and hair twice with 4% chlorhexidine soap Descutan® (Fresenius Kabi AB, Uppsala, Sweden) prior to surgery. and patients were prepared after skin disinfection with a microbial sealant. Most patients were elective and arrived the morning of surgery to the hospital. Following standard procedures, intravenously administered antibiotic prophylaxis (cloxacillin 2 g) was administrated at the ward 30 minutes before surgery. In the OR the patients wore a disposable cap and were positioned on the operating table. The OR temperature were 19°C with upward displacement ventilation. Sterile disposable surgical gowns (Samutprakarn, Thailand/Mölnlycke Health Care AB, Göteborg, Sweden) and indicator gloves (Selangor, Malaysia/Mölnlycke Health Care AB Göteborg, Sweden) were worn by the surgeon and OR nurse. Other OR staff (n=2) wore cotton scrubs, short-sleeved tunic shirt with cuffs at the arms, and trousers with cuffs at the ankles. They also wore disposable helmets and facemasks. Both groups were given skin disinfection during 2 minutes with the same amount of solution (Chlorhexidine 5mg/ml in 70% alcohol). The skin disinfection (Chlorhexidine 5mg/ml, in alcohol) was stored in room-temperature and was measured to keep 20ᵒC while the preheated was stored in a warming cupboard who kept 36ᵒC. The participants were disinfected from cheek down over sternum according to routine procedures. Sterile material for draping and clothing were for single use only. Cultures were obtained at four occasions using a nylon flocked swab (Copan ESwab, Italia SpA): before skin disinfection on skin surface; after skin disinfection on skin surface; directly after the incision, at completion of the incision, and finally before start of closing sutures. Swab cultures were rubbed for 15 seconds slightly moist with saline on skin surface (incision site). Swabs taken in the wound were rubbed along the inside of the incision for 15 seconds with a dry swab. Surgery was performed by two cardiologists. Cultures were kept cold until arrival at the Department of Laboratory medicine, Clinical Microbiology. Cultures were taken care of and analyzed according to a specific protocol designed especially for the study.
This is an exploratory, single-center, open-label, single-arm study with microbiological endpoint using photobiomodulation (PBM) and topical disinfectants to determine the effect on the nasal microbiota.

The photobiomodulation system distributes about 700mW of light to each nostril using a 2-channel diode laser with non-thermal, red light. The topical disinfectants are methylene blue (0.01%) and chlorhexidine gluconate (0.25%). Following a pretreatment nasal culture, these two disinfectants will be administered into the patient's anterior nares followed by a two-minute light cycle. This process is repeated once more resulting in two treatments cycles (4-minutes total). Following this, nasal cultures are taken immediately and at 4-, 8-, 24-, and 48- hours. Broad spectrum and Staphylococcus spp. culturing of nasal swabs will be conducted. Swabs will also be submitted for Next Generation Sequencing to characterize the effect of light and disinfectants on the nasal microbiome.
BACKGROUND: Cirrhosis continues to be the most common cause of chronic liver disease-related deaths globally, which puts significant strain on global health. This report aims to investigate the patterns of cirrhosis in China, the United States, India and worldwide from 1990 to 2019 through an epidemiological analysis of the disease utilizing data from the Global Burden of Disease Study (GBD) 2019 database.
METHODS: Download the GBD database's statistics on liver cirrhosis deaths and Disability-Adjusted Life Years for the years 1990-2019 worldwide as well as for China, the United States and India. Utilize techniques like age-period-cohort interaction, decomposition analysis, study of health inequities, Joinpoint model and Bayesian Average Annual Percentage Change model to process the data.
RESULTS: The main age group affected by cirrhosis disease, according to the results, is 50-69 years old. According to the Joinpoint model, there has been a negative worldwide Average Annual Percent Change (AAPC) in the burden of cirrhosis between 1990 and 2019. Only the USA's AAPC is positive out of the three nations that were evaluated (albeit its 95% confidence interval spans 0). These are China, India and the United States. Forecasting models indicate that the prevalence of cirrhosis will keep rising in the absence of government action. According to decomposition analysis, the main factors contributing to the rising burden of cirrhosis are population ageing and size, whereas changes in the disease's epidemiology slow the disease's growth. Research on health disparities indicates that, between 1990 and 2019, there was a downward trend in health disparities between various locations.
CONCLUSION: Health organizations across different areas should take aggressive measures to address the worrisome prevalence of cirrhosis.
Insect respiration has long been thought to be solely dependent on an elaborate tracheal system without assistance from the circulatory system or immune cells1,2. Here we describe that Drosophila crystal cells-myeloid-like immune cells called haemocytes-control respiration by oxygenating Prophenoloxidase 2 (PPO2) proteins. Crystal cells direct the movement of haemocytes between the trachea of the larval body wall and the circulation to collect oxygen. Aided by copper and a neutral pH, oxygen is trapped in the crystalline structures of PPO2 in crystal cells. Conversely, PPO2 crystals can be dissolved when carbonic anhydrase lowers the intracellular pH and then reassembled into crystals in cellulo by adhering to the trachea. Physiologically, larvae lacking crystal cells or PPO2, or those expressing a copper-binding mutant of PPO2, display hypoxic responses under normoxic conditions and are susceptible to hypoxia. These hypoxic phenotypes can be rescued by hyperoxia, expression of arthropod haemocyanin or prevention of larval burrowing activity to expose their respiratory organs. Thus, we propose that insect immune cells collaborate with the tracheal system to reserve and transport oxygen through the phase transition of PPO2 crystals, facilitating internal oxygen homeostasis in a process that is comparable to vertebrate respiration.
ABSTRACT OF THE DISCLOSURE     The invention relates to novel basic ethers of the general formula /I/ and pharmaceutically acceptable acid addition salts and quaternary salt,  thereof,                       /I/     wherein R1 and R2 may be the same or different and represent a C1-5 alkyl group or a C3-6 cycloalkyl group or they form, together with the adjacent nitrogen atom, a heterocyclic ring containing 4-7 carbon atoms and optionally a further hetero atom, e.g. an oxygen, sulfur or nitrogen atom, and his latter may be optionally substituted by a C1-3 alkyl, benzyl or phenyl group, R represents a phenyl, phenyl-/C1-3 alkyl/ or ? group ?        substituted by one or more halogen or C1-3    ?   ?   substituent/s/, A represents a C2-5 straight or branched alkylene chain, and ?              represents a  valence bond of ?  or .beta. configuration.           The compounds of the general formula /I/ are prepared according to the invention a./ by reacting a compound of the general formula /II/       /II/   wherein R has the same meaning as above, whereas R3 denotes an alkali metal atom, an alkali-earth metal atom or a group of the general formula  ?-Me, wherein ? denotes halogen and Me stands for alkali-earth metal atom, with a compound of the general formula /III/                                             /III/ wherein Y stands for halogen and A, R1 and R2 have the same meaning as above; or b./ by treating a compound of the general formula /IV/                 /IV/   wherein R has the same ?  ?  as above, with an agent suitable ? ? produce as R3 group and reacting the compound of the general formula /II/ thus obtained, wherein R and R3 have the above-defined  ?, with a compound of the general ?  ?    /III/; or c./ by reacting 1,7,7-trimethy-bicycle/2.2.1/ ?-2-one of the formula /V/ with ? as ? -metallic compound, decomposing the complex thus obtained, and reacting the compound of the general formula /IV/ thus obtained, wherein R has the above defined meaning, with a base suitable to introduce an R3 group, and reacting the compound of the general formula /II/ thus obtained with a compound of the general formula /III/, and, if desired, converting the compound of the general formula /I/ thus obtained into a pharmaceutically acceptable acid addition salt or quaternary salt.      The new compounds of the general formula /I/ possess valuable anticonvulsive, motility inhibiting, hexobarbital narcose potentiating and analgesic effects, which are, in case of certain compounds, complemented by weak antiserotonine, gastro-intestinal-tract inhibiting and antiinflammatory effects, and can be applied to advantage in the therapy.
Serine hydrolases are implicated in malconditions such as cancer, central nervous system disorders, cardiovascular disorders, obesity, and metabolic disorders. Many serine hydrolases expressed in proteomic libraries are of unknown function in vivo. Compounds identified through library versus library screening can be used for treatment of malconditions associated with the specific serine hydrolase KIAA1363 (also known as AADACL1). A library of inhibitors of KIAA1363 was prepared and candidate compounds were identified as a potent inhibitors having submicromolar IC 50  values. An exemplary compound of the invention was shown to be an effective inhibitor of prostate cancer pathogenesis. Other inhibitory compounds of the invention comprising fluorophore groups are shown to be effective in spatial and temporal localization of the serine hydrolase in cells and tissues.
Background: Polymyalgia rheumatica (PMR) is an inflammatory condition closely linked with giant cell arteritis, which is a large vessel vasculitis. To provide real-world evidence on PMR outcomes and their determinants, we conducted a longitudinal study focusing on symptom relief and acute phase reactant normalization. Methods: We followed patients with PMR who were registered in Tabriz University of Medical Sciences Vasculitis Registry (TUOMS-VR) until February 2023. We measured sustained remission (primary outcome) and secondary outcomes including glucocorticoids (GCs)-free remission, medication-free remission, relapse rate and disease-induced damage. Results: We identified eighty-one patients with PMR and followed them for a median time of 57 months. In a median duration of 3 weeks, 98.8% of patients achieved symptom control, with 86.4% achieving sustained remission in a median duration of 9 weeks. Sustained remission was more common in non-smokers and adherent to therapy patients. Relapse occurred in 22.1% of patients, primarily due to non-adherence. Medication-free remission was observed in 30.9% of patients, especially among females and those with an initial prednisolone dose > 15 mg/d. Damage occurred in 42.0% of patients. Conclusion: Although sustained remission in PMR is not an unattainable goal in daily practice and most patients are in remission at the last visit, two-thirds of patients require long-term treatment.
PURPOSE:To obtain a toothpaste of high quality without containing air bubbles, by dispersing a powdery or granular material containing a polishing agent and a binder in a solution containing a wetting agent and water, deaerating the resultant slurry, and allowing the resultant slurry to stand to swell and dissolve the binder particles completely in the slurry. CONSTITUTION:A powdery or granular material containing a polishing agent, e.g. potassium secondary phosphate dihydrate, and a binder having 10-300mum average particle diameter, e.g. sodium carboxymethyl cellulose, or further a perfume is dispersed in a solution containing water and a wetting agent, e.g. glycerol, or further a surfactant, at 5-40 deg.C to form a slurry, which is then deaerated at 10-100mm.Hg (absolute pressure) reduced pressure while the binder is present in the particulate form. The slurry is then allowed to stand to swell and dissolve the binder particles completely in the slurry and give the aimed toothpaste. The time required for the powdery or granular material from the dispersion to the completion of the deaeration is 1-90sec. The resultant toothpaste will not easily deteriorate even for a long term.
Liver cyst infections often necessitate long-term hospital admission and are associated with considerable morbidity and mortality. We conducted a modified Delphi study to reach expert consensus for a clinical decision framework. The expert panel consisted of 24 medical specialists, including 12 hepatologists, from nine countries across Europe, North America, and Asia. The Delphi had three rounds. The first round (response rate 21/24 [88%]) was an online survey with questions constructed from literature review and expert opinion, in which experts were asked about their management preferences and rated possible management strategies for seven clinical scenarios. Experts also rated 14 clinical decision-making items for relevancy and defined treatment outcomes. During the second round (response rate 13/24 [54%]), items that did not reach consensus and newly suggested themes were discussed in an online panel meeting. In the third round (response rate 16/24 [67%]), experts voted on definitions and management strategies using an online survey based on previous answers. Consensus was predefined as a vote threshold of at least 75%. We identified five subclassifications of liver cyst infection according to cyst phenotypes and patient immune status and consensus on episode definitions (new, persistent, and recurrent) and criteria for treatment success or failure was reached. The experts agreed that fever and elevated C-reactive protein are pivotal decision-making items for initiating and evaluating the management of liver cyst infections. Consensus was reached on 26 management statements for patients with liver cyst infections across multiple clinical scenarios, including two treatment algorithms, which were merged into one after comments. We provide a clinical decision framework for physicians managing patients with liver cyst infections. This framework will facilitate uniformity in the management of liver cyst infections and can constitute the basis for the development of future guidelines.
Exercise will include a 3x/wk for eight weeks exercise protocol is designed to provide a high-volume, moderate-intensity whole body training stimulus. Placebo will include \~7-10 g of maltodextrin (100 mg/kg) daily for eight weeks.
PURPOSE: A pharmaceutical composition and a functional cosmetics composition for preventing or treating pimples, atopic dermatitis and pruritus and a manufacturing method thereof are provided to alleviate or treat pimples, atopic dermatitis and pruritus without side effects in short time. CONSTITUTION: A manufacturing method of pharmaceutical composition for preventing or treating pimples, atopic dermatitis and pruritus comprises the following steps: dissolving 1-3 parts by weight of organic acid based on 100 parts by weight of water; respectively putting zinc and iron at 1000-3000ppm concentration; reacting at 50-60 deg. Celsius for 48-72 hours; and refining after obtaining supernatant. The organic acid of the first step is citric acid. The functional cosmetics composition includes the organometallic compound as an active ingredient. The functional cosmetics composition is effective on pimples, atopic dermatitis and pruritus improvement.
Sham LLTS will be performed by use of a neuromodulation device with electrodes attached to the ear lobule. Stimulator will be applied continuously for 1 hour daily for 12 weeks.
The invention discloses a Chinese medicinal composition for treating stomach swelling. The Chinese medicinal composition comprises the following raw material medicaments in party by weight: 8 to 15 parts of cardamon white, 10 to 20 parts of root of straight ladybell, 25 to 35 parts of coix seed, 25 to 35 parts of Indian Buead, 10 to 20 parts of bighead atractylodes rhizome, 8 to 15 parts of bark of official magnolia, 8 to 15 parts of fortune eupatorium herb, 8 to 15 parts of storax, 25 to 35 parts of talc, 8 to 15 parts of bamboo leaf, 8 to 15 parts of dried orange peel and 3 to 8 parts of liquoric root. The compatibility idea of the composition is that: the cardamon white, the root of straight ladybell, the coix seed and the Indian Buead are used as monarch medicaments; the bighead atractylodes rhizome, the bark of official magnolia and the fortune eupatorium herb are used as ministerial medicaments; the storax, the talc and the bamboo leaf are used as adjuvant medicaments; and the dried old orange peel and the liquoric root are used as conductant medicaments. The Chinese medicinal composition fulfills the aim of treating the stomach swelling by nourishing yin, tonifying spleen, harmonizing the stomach and soothing the liver. The medicament of the invention is decocted with water by a conventional method and prepared into decoction and can also be prepared into powder, tablets and capsules by using the conventional method. The Chinese traditional medicine for treating the stomach swelling of the invention has the advantages of unique compatibility, skillful medicament combination, obvious effect on treatment of the stomach swelling, good therapeutic effect, low therapy cost and no side effect.
A sustained/immediate acting ketoprofen patch. A moisture permeable backing, a moisture non-permeable primer, a moisture high-permeable drug layer containing ketoprofen and a skin adhesion layer controlling release of a drug solution are piled up. An ethyl acetate soluble acrylic/rubber adhesive is coated onto a silicon coated paper, dried and transfer coated onto the backing to form the primer. The drug layer is formed by coating a drug solution onto a silicon coated paper, drying and transfer coating onto the primer. The skin adhesion layer is formed by coating a mixture of a solution prepared by dissolving an emulsifier in ethyl acetate and acrylic adhesive, drying and transfer coating onto the drug layer. The ketoprofen patch has a drug release controlling function and a good adhesion strength. The drug transferring effect through the skin is good.