anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Paclitaxel 155 mg/m2 i.v., epirubicin 75 mg/m2 i.v day 1, capecitabine 1650 mg/m2 p.o. on days 1-14 every 21 days.
The invention relates to an application of pseudoaltermonas extracellular polysaccharide in inhibition of proliferation of breast cancer cells. The molecular weight of the pseudoaltermonas sp. S-5 extracellular polysaccharide is 397 kDa; the pseudoaltermonas sp. S-5 extracellular polysaccharide is composed of mannose, glucose and galactose at the mole ratio of 4.8:50.9:44.3. The pseudoaltermonas sp. S-5 extracellular polysaccharide disclosed by the invention can inhibit the proliferation of MDA-MB-231 cells in vitro and inhibit the growth of tumor cells, and the inhibition is achieved mainly by using the pseudoaltermonas sp. S-5 extracellular polysaccharide to induce apoptosis of the MDA-MB-231 cells, so the extracellular polysaccharide has the application prospect in preparation of medicament for inhibiting the proliferation of the MDA-MB-231 cells.
During a visual feedback session, therapists will spend 30min per session using the Mobility Rehab system for gait training with patients. Therapists may select modality, overground walking and/or treadmill, tasks (dual task, head turns, etc. as above) as appropriate for each patient. They will additionally spend 15min on endurance, strength, and static and dynamic balance in functional tasks.
FIELD: chemistry of heterocyclic compounds. SUBSTANCE: invention relates to compounds of the formula (I)   where Y means 3-quinolinyl group or 2-indolyl group of the formula (II)   where R means hydrogen, acetyl group or group CH 2 COOR′ being R′ means hydrogen or C 1 -C 4 -alkyl; X means (hetero)aryl radical taken from a group given in description; Z means hydrogen, C 1 -C 4 -alkyl or benzyl, and their salts and solvates also. Invention relates to also a method of synthesis of compounds of the formula (I), intermediate compounds for synthesis and a pharmaceutical composition based on compounds said. Synthesized compounds show agonism with respect to cholecystokinin receptors and can be used for treatment of patients with disorders caused by cholecystokinin. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 12 cl, 4 tbl, 34 ex
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and the third leading cause of cancer-related mortality. Extensive literature suggests that long noncoding RNAs play a role in the progression of HCC and hold potential as diagnostic biomarkers for this disease.
MATERIALS AND METHODS: We examined the serum levels of HOX antisense intergenic RNA (HOTAIR) in 49 hepatitis patients, 31 liver cirrhosis (LC), and 37 HCC patients using quantitative real-time polymerase chain reaction. Correlations between serum HOTAIR levels and clinical data were evaluated in HCC patients. The receiver operating characteristic curve was utilized to analyze the diagnostic potency of HOTAIR.
RESULTS: The HOTAIR levels in serum were significantly higher in HCC patients compared to those with hepatitis (P = .003) and LC patients (P = .048). There was a significant association between the serum levels of HOTAIR and positivity of hepatitis B e antigen (HBeAg) (P = .039) as well as portal vein tumor thrombus (P = .040) in HCC patients. The area under the curve (AUC) for HOTAIR for distinguishing HCC from hepatitis and LC was 0.697. The combined AUC for HOTAIR, HBeAg, and alpha-fetoprotein (AFP) was 0.777.
CONCLUSION: Serum HOTAIR functions as a potential diagnostic marker for hepatitis B virus-related HCC. Combining HOTAIR with clinical data and AFP can reinforce the diagnostic precision on HCC.
The patients will be allocated into two groups: control and study group _ In study group, patients will be treated by DuoStim protocol: The first phase of ovarian stimulation is started on the second day or third day of period. GnRH agonist will be used to trigger when at least two follicles ≥ 17 mm. Approximately 36 hours later, oocytes will be retrieved vaginally under ultrasound monitoring and ICSI will be performed. Five days later after oocyte retrieval, the second stimulation will be started. All embryos will be cryopreserved.

_ In control group, patients will be treated with antagonist protocol: The cycle of ovarian stimulation is started on the second day or third day of period. hCG will be used to trigger when at least two follicles ≥ 17 mm. Approximately 36 hours later, oocytes will be retrieved vaginally under ultrasound monitoring and ICSI will be performed. If serum progesterone on the day of trigger ≥ 1.5 ng/ml, all embryos will be cryostored; otherwise, fresh embryos will be transferred.
PURPOSE:To obtain an instillation having improved antiseptic effect and low stimulation and useful as a remedy for xerosis corneae and keratitis by using hyaluronic acid and its salt as essential component and compounding benzalkonium chloride and a chelating agent to the component. CONSTITUTION:Benzalkonium chloride and a chelating agent are compounded to an instillation containing hyaluronic acid and its salt. Benzalkonium chloride is a compound expressed by formula (R is alkyl) and the antiseptic effect of the component can be improved by adding a chelating agent (e.g. polycarboxylic acid such as sodium edetate and sodium cyclohexanediaminetetraaectic acid). The amount of benzalkonium chloride can be decreased and an instillation having reduced stimulation can be produced by the addition of the chelating agent. The concentration of benzalkonium chloride is preferably 0.002-0.01%, especially 0.0025-0.005% and that of the chelating agent is preferably 0.001-0.1%.
The invention relates to a traditional Chinese medicine preparation for treating femoral head aseptic necrosis, namely Shechuanggujietengtongjiaonang. The traditional Chinese medicine preparation comprises the following medicines in percentage by weight: 90-120g of ginseng, 90-120g of Astragalus membranaceus, 90-120g of cartialgenous, 90-120g of the root of red-rooted salvia, 90-120g of dragon's blood, 40-60g of frankincense, 40-60g of myrrh, 90-120g of herba lycopi, 90-120g of Alternantheradentata Rubiginosa, 8-12g of musk, 90-120g of Manis pentadactyla and the like. The medicines are processed by a conventional method and are smashed and sieved to obtain 100-120 meshes powder, and the powder is prepared into capsules to be orally taken. Through clinical application, the clinical symptoms can be relieved in about two months, and the preparation is taken continuously for 4-6 months to clinically cure the patients in stages I and II without wadding and recover the function. For the patients in the stage III with wadding, even through the gait is not corrected, other pain and symptoms can be thoroughly relieved. No remarkable side effects are found.
BACKGROUND: Vitamins are essential micronutrients that play key roles in many biological pathways associated with sepsis. The gut microbiome plays a pivotal role in the progression of sepsis and may contribute to the onset of multi-organ dysfunction syndrome (MODS). The aim of this study was to investigate the changes in serum vitamins, and their correlation with intestinal flora and metabolomic profiles in patients with sepsis.
METHODS: The serum levels of vitamins were determined by Ultra Performance Liquid Chromatography (UPLC). 16S rRNA gene sequencing and Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) targeted metabolomics were used for microbiome and metabolome analysis.
RESULTS: In the training cohort: After univariate, multivariate (OPLS-DA) and Spearman analyses, it was concluded that vitamin levels of 25 (OH) VD3 and (VD2 + VD3), as well as vitamins A and B9, differed significantly among healthy controls (HC), non-septic critical patients (NS), and sepsis patients (SS) (P < 0.05). The validation cohort confirmed the differential vitamin findings from the training cohort. Moreover, analyses of gut flora and metabolites in septic patients and healthy individuals revealed differential flora, metabolites, and metabolic pathways that were linked to alterations in serum vitamin levels. We found for the first time that vitamin B9 was negatively correlated with g_Sellimonas.
CONCLUSION: Sepsis patients exhibited significantly lower levels of 25 (OH) VD3 and (VD2 + VD3), vitamins A and B9, which hold potential as predictive markers for sepsis prognosis. The changes in these vitamins may be associated with inflammatory factors, oxidative stress, and changes in gut flora.
PROBLEM TO BE SOLVED: To obtain a trehalose derivative excellent in surface-active ability and safety to skin and useful as a surfactant, etc., capable of using for cosmetics, medicines, foods, etc., by reacting trehalose with an acetal compound in the presence of an acid catalyst. SOLUTION: This new trehalose derivative is expressed by formula I (R1 is a 7-21C saturated or unsaturated hydrocarbon; R2 is H, a 1-22C saturated or unsaturated hydrocarbon) (e.g. 4,6-laurylidene-trehalose) and is excellent in surface-active ability and safety to skin and widely utilizable for cosmetics, medicines, foods, etc., e.g. as a skin cleansing agent, a hair cleansing agent, a skin-maintaining agent, a hair-maintaining agent, a make up agent, a bathing agent or soap. The compound is obtained by condensing trehalose with an aliphatic hydrocarbon chain expressed by formula II (R3 is methyl or ethyl) and a saturated or unsaturated 8-22C acetal compound (e.g. dodecanaldiethylacetal) in the presence of an acid catalyst.
The invention belongs to the field of medicinal preparation, and particularly relates to a lyophobic and modified glucan-modified long circulating liposome, a preparation method thereof and application thereof. The liposome consists of phospholipids, cholesterol and lyophobic and modified glucan. The liposome is characterized in that the lyophobic chain segment part of the lyophobic and modified glucan enters into the lyophobic layer of the liposome due to the drive of entropy so as to improve the stability of the inner structure of the liposome; and the hydrophilic chain segment part is positioned at the hydrophilic outer layer of the liposome so as to play a part in three-dimensional stability and internal long circulation. The yophobic and modified glucan can be prepared by the reaction between oleamide and carboxymethyl glucan. The liposome is applied to various carriers of medicines, nutrient substances, perfumes and dyes, has high packing rate, mean grain diameter, good stability and good redispersibility, and can be stored by means of freeze-drying. Compared with the existing PEG-modified long circulating liposome, the liposome has the advantages of low cost and being more convenient in further modifying the targeted function.
A composition for controlled delivery of at least one active substance into an aqueous medium by erosion at a preprogrammed rate of at least one surface of the composition, the composition comprising a matrix which is erodible in the aqueous medium in which the composition is to be used and which allows substantially no diffusion of water into the composition beyond any exposed surface layers of the matrix, the matrix comprising at least one substantially water soluble crystalline polymer, e.g. a polyethylene glycol, with at least one water-dispersible or water-soluble surface active agent, e.g. a non-ionic emulsifier, dispersed therein, at least one release modifier, e.g. an enteric coating material, that functions to regulate erosion of the matrix within a pH range of from about 2 to about 7, and at least one active substance. The composition provides controlled, e.g. substantially zero order, release in both the stomach and the intestines despite different conditions of pH, agitation and absorption.
Gout is a recurrent chronic inflammatory disease caused by monosodium urate (MSU) crystal . Acute gouty arthritis (GA) is the most common first symptom of gout. With the progress of the disease, the frequency of acute attack increases, and joint destruction may occur. The prevalence of hyperuricemia in China was about 13.3%, and the pooled prevalence of gout was 1.1%. Repeated attacks of GA seriously affect the quality of life, resulting in huge economic costs and mental stress. Due to inadequate prevention and treatment, the target of healing gout is often not achieved. In GA, TCM has shown satisfactory therapeutic effect with less adverse effects and minimal toxicity. Huzhang granule (HZG), a Chinese herbal prescription, is a compound preparation with twelve ingredients which has been used in the clinical treatment of gout for over 30 years at the Yueyang Hospital of Integrated Traditional Chinese and Western Medicine affiliated to Shanghai University of TCM.Therefore，this double-blind, randomized, controlled clinical trial. will provide high-quality clinical evidences for evaluating the clinical efficacy, safety and control of recurrence rate of Huzhang granule ，a representative prescription for the treatment of acute gouty arthritis , in the treatment of GA.
NEW MATERIAL:A compound expressed by formula I [R is (lower alkyl and lower alkoxy-substituted)indole; A is alkylene, P is single bond or (amino, alkylamino or benzyloxycarbonylamino-substituted) alkylene; R1 is lower alkyl, aralkyl, alkylaminocarbonylalkyl or amino(aminoalkyl)alkylcarbonyloxyalkyl which may be protected with an amino-protecting group] and salt thereof. EXAMPLE:Ethyl N-benzyloxycarbonyl-O-(beta-indoleacetyl)-L-tyrosinate. USE:A medicine. A remedy for human or animal pancreas disease, blending agent with insulin and preservative for fresh food such as meat, fish, etc. The new material has chymotrypsin-hindering action. PREPARATION:4-Substituted phenols expressed by formula II is subjected to esterification with carboxylic acids expressed by formula III in the presence of a dehydrating agent such as dicyclohexylcarbodiimide, etc., to provide the compound expressed by formula I.
Participants use wearable device and their heart rate and activity are monitored. If their resting heart rate (rHR) increase beyond the set range or they have hyperthyroid symptoms and signs, they should come to the hospital and get tests for thyroid function. If their rHR stay within set range and they have no symptoms and signs, they come to hospital and get tests for thyroid function 6 months after discontinuing anti-thyroid drugs.
Risperidone, widely used in the treatment of schizophrenia, has been shown to be effective in the treatment of manic and mixed episodes associated with bipolar disorders. Antipsychotic drugs like risperidone have also been used as therapeutic agents in the treatment of patients who are not responsive to mood stabilizers alone. This is a randomized, double-blind study to evaluate the effectiveness and safety of risperidone compared with placebo, as an addition to mood stabilizing drugs, in the treatment of patients experiencing manic episodes associated with bipolar disorder. The study has two phases: a double-blind treatment phase (3 weeks) and an open-label phase (10 weeks). To participate in the study, patients must be in-patients for a minimum of the first 4 days of double-blind treatment. During the double-blind treatment phase, patients receive risperidone or placebo tablets to be taken once a day at gradually increasing doses at investigator's discretion, up to a maximum dose of 6 mg/day, while continuing their treatment with a mood stabilizer (lithium, valproate, or carbamazepine). In the open-label phase, therapy with a mood stabilizer continues, and all patients receive risperidone with dosage gradually adjusted to achieve optimal effectiveness. The primary measure of effectiveness is the change in Young Mania Rating Scale (YMRS) total score from baseline to end of double-blind treatment. Additional efficacy measures include the Brief Psychiatric Rating Scale (BPRS), the Clinical Global Impression (CGI), (which evaluates the change in severity of the disorder), and the Hamilton Depression Rating Scale (HAMD). Safety assessments include the incidence of adverse events throughout the study; measurement of vital signs (pulse and blood pressure) and evaluation of the presence and severity of extrapyramidal symptoms by the Extrapyramidal Symptom Rating Scale (ESRS) at specified intervals; and clinical laboratory tests (hematology, biochemistry, urinalysis) before study initiation, at completion of the double-blind treatment, and at the end of the study. The study hypothesis is that daily treatment with risperidone as add-on therapy provides better effectiveness than the addition of placebo, as measured by Young Mania Rating Scale scores, in the treatment of the manic phase of bipolar disorder. Risperidone 1 mg tablets, taken orally, once daily; Doses of 2 mg on Days 1 and 2, up to 4 mg on Days 3 and 4, and up to 6 mg (maximum dose) on Days 5 through 21. Same dose maintained through the 10 week open-label phase. Gradual dose adjustments are allowed to achieve optimal effectiveness.
PCT No. PCT/EP93/00259 Sec. 371 Date Jul. 20, 1994 Sec. 102(e) Date Jul. 20, 1994 PCT Filed Feb. 4, 1993 PCT Pub. No. WO93/15109 PCT Pub. Date Aug. 5, 1993The invention concerns parathormone (PTH) fragments including the amino acid range of the natural parathormone of +3 to +35 and their physiologically compatible derivatives, a process for the preparation of the fragments according to the solid phase and liquid phase synthesis from partly blocked amino acids contained in the fragments which are coupled with one another in the sequence which corresponds to the amino acid sequence in the fragments to be prepared and medicaments containing at least one of the fragments, especially with calcium-regulating action in the body.
Systems and method for identifying and providing protocol variances are provided. In embodiments, the method includes referencing an ordered protocol associated with a health condition for a patient. Such an ordered protocol includes a plan for a course of health or medical treatment for the health condition of the patient. A standard protocol that corresponds with the ordered protocol is also referenced. Thereafter, the ordered protocol is compared to the standard protocol to identify at least one protocol variance that indicates a portion of the ordered protocol has been adjusted as compared to the standard protocol. Any identified protocol variances are presented, for example, to a user computing device for display to a user.
The second arm is an open label study to evaluate the safety, efficacy, and pharmacokinetics of ME-401 in combination with rituximab in subjects with various B-cell malignancies. There are two planned cohorts which may enroll up to 30 subjects.
The invention provides a soft mask powder mask suitable for sensitive muscles. The invention further provides a preparation method of the soft film powder. The invention further provides a facial mask. The invention further provides a preparation method of the facial mask. The invention particularly provides the use of a soft mask powder or a facial mask in skin care. The prepared soft mask powder mask is good in film forming property, can be completely torn off, is easy to stir, is a product with fine and smooth product, has good moisturizing, soothing, repairing and brightening effects, has excellent skin feeling and excellent effects, and is popular with consumers.
This study investigated how the school experiences and personal characteristics of youth with Intellectual Disabilities (ID) contribute to their longitudinal trajectories of anxiety. To this end, we relied on a sample of 390 youth with mild (48.2%) to moderate (51.8%) levels of ID, aged from 11 to 22 (M = 15.70), and recruited in Canada (n = 140) and Australia (n = 250). Across three yearly time points, all participants completed self-report measures of anxiety, school climate, and victimization. Our results revealed a slight normative decrease in anxiety over time and showed that experiences of school victimization were associated with higher levels of anxiety (initially and momentarily) and increases in victimization were accompanied by increases in anxiety over time. Perceptions of attending a school that fosters security and promotes learning also tended to be accompanied by lower levels of anxiety (initially and momentarily). Momentary increases in perceptions of attending a school that fosters positive peer interactions were associated with momentary decreases in anxiety, whereas momentary increases in perceptions of attending a school characterized by positive teacher-student relationships and an equitable treatment of all students both led to small momentary increases in anxiety once all other components of student school experiences were considered. The theoretical and practical implications of these results are discussed.
PURPOSE OF REVIEW: This narrative review summarizes current literature on the relationship of mitochondrial biomarkers with obesity-related characteristics, including body mass index and body composition.
RECENT FINDINGS: Mitochondria, as cellular powerhouses, play a pivotal role in energy production and the regulation of metabolic process. Altered mitochondrial functions contribute to obesity, yet evidence of the intricate relationship between mitochondrial dynamics and obesity-related outcomes in human population studies is scarce and warrants further attention. We discuss emerging evidence linking obesity and related health outcomes to impaired oxidative phosphorylation pathways, oxidative stress and mtDNA variants, copy number and methylation, all hallmark of suboptimal mitochondrial function. We also explore the influence of dietary interventions and metabolic and bariatric surgery procedures on restoring mitochondrial attributes of individuals with obesity. Finally, we report on the potential knowledge gaps in the mitochondrial dynamics for human health for future study.
Patients included in the experimental arm will be treated with intravenous infusion of paclitaxel 175 mg/m2, followed by carboplatin 5 area under the curve (AUC). This will be administered in a 3-weekly scheme with preferably 3 and a maximum of 4 courses, with evaluation after two courses of chemotherapy by physical examination. NACT will be subsequently followed by radical surgery in responding patients. A four to six weeks interval after the last course of chemotherapy needs to be respected before surgery, to allow sufficient physical recovery.
Participants in group 4 will be recruited at their stress echocardiogram appointment, regardless of the type of investigation. A simplified data set and an anonymised version of the stress echocardiography report will be collected as a part of this registry phase. Participants will be followed up over a 10-year period.
The objective of this study was to determine if preoperative patient characteristics have an effect on pain and function after primary arthroscopic rotator cuff repair. Seventy-five arthroscopic primary rotator cuff repairs with at least 2 years of follow-up were identified. Studied variables were preoperative tobacco, opioid, and alcohol use; obesity; mood disorders; disability claim; and Workers' Compensation status. Outcome measures included visual analog pain scores, American Shoulder and Elbow Surgeons (ASES) scores, Single Assessment Numeric Evaluation (SANE) scores, range of motion, and strength. Preoperative smoking was significantly associated with worse pain (p = 0.009), ASES (p = 0.004), and SANE (p = 0.011) scores. Opioid use showed no statistically significant difference in pain or functional scores. Alcohol use did predict improved ASES scores at long-term follow-up (p = 0.046). The other variables were not associated with inferior outcomes. Smoking and preoperative opioid use represent modifiable risk factors that can be corrected before surgery to optimize outcomes. (Journal of Surgical Orthopaedic Advances 33(1):005-009, 2024).
The schizophrenic patients group will benefit from language assessment, TLC and CAST. They are between 18 and 55 years old and are cared for as part of their usual follow-up at the CPN. They must have been diagnosed with schizophrenia according to DSM-5 (Diagnostic and Statistical Manual of Mental Disorders) criteria.