anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Coronary artery fistula is a rare anomaly involving the coronary artery and a heart chamber or vessel. Percutaneous intervention has been shown to be effective and safe in fistulas that are small and nontortuous; however, it is not an absolute contraindication in fistulas that are large and tortuous. We report a delayed diagnosis of a single, large-diameter, tortuous coronary artery fistula that manifested as myocardial ischaemia due to the steal phenomenon in a 49 year old male. The undesirable connection was successfully obliterated by percutaneous embolisation, followed by an improvement in symptoms and daily activities. Steal phenomenon is the fundamental mechanism of myocardial ischaemia in coronary artery fistula, as confirmed by improvement in symptoms and coronary artery perfusion following occlusion of the fistula. Percutaneous catheterization is safe and effective for coronary artery fistula closure, and the occlusion site should be precise to achieve complete occlusion and prevent complications.
Adolescents will watch an equally short (10 min) DVD on healthy lifestyles and behaviors. HPV awareness and vaccination will not be addressed.
Systemic sclerosis (SSc) is a life-threatening autoimmune disease characterized by widespread fibrosis in the skin and several internal organs. Nudix Hydrolase 21 (NUDT2 or CFIm25) downregulation in fibroblasts is known to play detrimental roles in both skin and lung fibrosis. This study aims to investigate the upstream mechanisms that lead to NUDT21 repression in skin fibrosis. We identified transforming growth factor β (TGFβ1) as the primary cytokine that downregulated NUDT21 in normal skin fibroblasts. In the bleomycin-induced dermal fibrosis model, consistent with the peak activation of TGFβ1 at the late fibrotic stage, NUDT21 was downregulated at this stage, and delayed NUDT21 knockdown during this fibrotic phase led to enhanced fibrotic response to bleomycin. Further investigation suggested TGFβ downregulated NUDT21 through microRNA (miRNA) 181a and 181b induction. Both miR-181a and miR-181b were elevated in bleomycin-induced skin fibrosis in mice and primary fibroblasts isolated from SSc patients, and they directly targeted NUDT21 and led to its downregulation in skin fibroblasts. Functional studies demonstrated that miR-181a and miR-181b inhibitors attenuated bleomycin-induced skin fibrosis in mice in association with decreased NUDT21 expression, while miR-181a and miR-181b mimics promoted bleomycin-induced fibrosis. Overall, these findings suggest a novel role for miR-181a/b in SSc pathogenesis by repressing NUDT21 expression.
OBJECTIVES: Morphometric information of the structures within the borders of the aortic root is a guide for surgical interventions. It is essential to determine the effects of aortic calcification and atheroma plaque findings on the structures of this region. This study aims to establish the normal values of aortic root structures and to investigate the impact of pathologic findings in order to guide diagnosis and treatment in the clinic.
METHODS: The aortic root structures were morphometrically analyzed in fresh hearts of 110 patients (89 males, 21 females) brought to the forensic medicine institution. The distances between the bases of the aortic sinuses, their widths and heights, and the lengths of the commissures were measured to differentiate between pathologic and non-pathologic aortic classes. Parameters were compared according to gender, age, body mass index, and body surface area.
RESULTS: The mean age was 44.71 ± 15.57 years in 21 female patients and 53.66 ± 15.67 years in 89 male patients. The results of the pathologic aorta group with calcification and atheroma plaque findings were higher than the non-pathologic aorta group in all parameters (P < .05).
CONCLUSIONS: Calcification and the presence of atheroma plaque in the aorta increase the size of the structures at the aortic root. Gender, age, body mass index, and body surface area are among the criteria that will cause changes in the structures of this region. These results will help surgeons to know the normal values of aortic root structures and to consider the effects of pathologic findings in aortic valve repair operations.
A pharmaceutical composition containing: (1) flavopereirine and/or dihydroflavopereirine; (2) one or more compounds selected from the group consisting of naringin, naringenin and/or their esters or salts which are acceptable from a pharmaceutical standpoint; (3) RNA primers or R.L.B. (RNA fragments); (4) bioparyl. Flavopereirine is an alkaloid of the beta-carboline class. R.L.B. are particular fragments of RNA which act as primers for the replication of leucotyte DNA. Bioparyl is obtained from yellow leaves of the Gingko biloba tree by a special process of extraction, hydrolysis and separation. These products in combination are useful for treating patients suffering from viral diseases, especially AIDS.
Patients rcvd IV chemotherapy on days 1 and 15 of a 4-week cycle: gemcitabine 1000 mg/m2 and oxaliplatin 65 mg/m2 for up to 3 cycles. Two dose reductions per study drug were permitted. On study, chemotherapy was followed by radiation therapy (RT) within 4-6 weeks of last chemotherapy. RT regimen was tumor-volume directed.
An approach for analyzing data collected by a sensor-enabled device over a network is provided. Specifically, in a typical embodiment, a set of usage data will be received from a device over a network. The set of usage data may be collected via at least one sensor integrated with the device, and the set of usage data may pertain to use of the device by a user. Regardless, the set of usage data will be compared to a set of diagnostic information stored in at least one computer storage device. The set of diagnostic information typically pertains to a condition (e.g., medical) treated by use of the device (e.g., dental, cardiac, renal, etc.). Based on the comparison, at least one determination (e.g., diagnosis, treatment plan, level of compliance with applicable standards, etc.) will be made and a set of reports will be generated based thereon.
Pharmaceutical anticonvulsant compositions comprise a carrier and a compound of the general formula <FORM:0950529/A5-A6/1> where R stands for a hydrocarbon radial, e.g. a C1-12 alkyl radical or an aryl radical containing not more than 10 carbon atoms, e.g. the phenyl, naphthyl and tetrahydronaphthyl radicals. They may be in conventional forms suitable for oral, parenteral and rectal administration, e.g. a tablet, capsule, aqueous or oily suspension, dispersable powder, syrup, elixir, injectable solutions or suspensions, e.g. in 1,3-butane diol and suppositories such forms comprising conventional diluents and excipients.  Specification 916,061 is referred to.
This is the treatment group. Patients will be ventilated using the new device (Evone) applying flow controlled ventilation for 48 hours. Ventilation parameters will be assessed every 6-8 hours. All other treatment will be unchanged and according to institutional standards.
The prevalence of blindness in the US adult population is 0.8% and ranges from about 3/10000 to 15/10000 in children. Data from world health organization show that about 500,000 children become blind each year. The annual cost of blindness to the federal government is $4 billion and the cost of a lifetime of support and unpaid taxes for a blind person is about $1 million.

There is a need to restore vision for blind patients. Research on vision restoration develops fast. There are multiple types of approaches toward producing useful artificial vision. One of them directly sends images from a video camera to the visual cortex via an electrode array that is intracranially placed on the visual cortex of blind patients. Another one surgically places an electrode array beneath the retina for patients whose optic nerves are still healthy. Both of them require major surgery and have high risks, and neither is available for routine clinical application.

The one that is non-invasive and easy to use is called the BrainPort® system. The BrainPort® system is manufactured by Wicab, Inc. It is commercially available and affordable to any consumer. This system is a novel, bionic, non-invasive, vision bypass system that conveys environment images from a spectacle-frame-mounted video-camera to the brain via an electro-tactile tongue array. The electro-tactile stimulation delivered by the tongue-array placed on the tongue allows users to interpret the images of objects in their camera's visual field.
Use of at least one strain of a microorganism and/or a metabolite thereof in the manufacture of a support for administration to a subject for modulating satiety signalling, wherein the support is a pharmaceutically acceptable support or a food product. Suitably, the at least one strain of a microorganism and/or a metabolite thereof may be administered to the subject for the treatment and/or prevention of excess weight and/or a disease caused by excess weight. Likewise, the at least one strain of a microorganism and/or a metabolite thereof is administered to the subject for the treatment and/or prevention of obesity and/or a caused by obesity. Preferably, the microorganism is a probiotic microorganism. Suitably the microorganism may be a lactic acid bacterium. Li one embodiment the microorganism is a strain of  Lactobacillus  spp. and/or  Bifidobacterium  spp., for example a strain of  Lactobacillus acidophilus, L. curvatus, L. salivarius  and/or  B. lactis.
BACKGROUND/AIM: Individuals with special healthcare needs (SHCN) are more likely to sustain traumatic dental injuries (TDIs) due to distinct risk factors. The aim of this review was to assess various risk factors associated with TDIs in individuals with SHCN.
MATERIALS AND METHODS: The protocol was designed according to the recommendations of the Cochrane-handbook, Joanna Briggs Institute, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered in PROSPERO (CRD42022357422). A comprehensive search was performed in PubMed, LILACS, Web of Science, EMBASE and Scopus using a pre-defined strategy without any limitation of language and year of publication. It was last updated on 25 April 2023. Studies addressing the TDIs in individuals with SHCN were included. Data extraction and analyses were performed, risk of bias (ROB) assessment was done using the Joanna Briggs Institute's critical appraisal tool, and a meta-analysis was performed using random-effects model.
RESULTS: A total of 21 studies were included in the review. They were categorized according to the target disease/condition: cerebral palsy (n = 5), ADHD and autism spectrum disorders (n = 5), visually impaired (n = 4), and multiple disorders (n = 7). The studies showed variability in the design and methods; however, 17 out of 21 studies showed moderate to low ROB. Increased overjet and lip incompetence were the main risk factors reported in the studies. The commonest injuries were observed to be enamel and enamel and dentine fractures.
CONCLUSION: The overall pooled prevalence of TDI in individuals with special healthcare needs was 23.16% with 20.98% in males and 27.06% in females. Overjet >3 mm and inadequate lip coverage were found to be associated with a higher risk of TDI in all the categories of individuals with special healthcare needs except ADHD and ASD. Falls at home in cerebral palsy, falls while walking and self-harm in ADHD and ASD, falls at home and collision in visual impairment, and unspecified falls in multiple disorders could be identified as the most common cause of TDI.
This is the control group. Patients will be treated only if grade 3 rash develops. For grade 3 rash, treatment will be in accordance with that of Grade 3 rash in Treatment Arm 2.
A preparation effective against diseases of the mouth cavity is obtained by inoculating a nutrient medium containing powdered unroasted coffee beans, carbohydrates, a source of nitrogen and trace elements and having a pH of 5-7, with bacteria which in the form of saliva and/or smears have been taken from the mouth of a healthy human or humans suffering from diseases of the mouth cavity, and allowing the bacteria to grow under non-sterile conditions in surface or submerged culture at a temperature of 18-28  DEG C. and the culture broth, preferably after clarification, is incorporated into a pharmaceutical carrier.  In the example, boiling water is added to oat-flakes and unroasted green coffee beans.  The mixture is cooled, the pH adjusted with tartaric acid, inoculated with saliva and a smear taken from the mouth cavity of a human suffering from aphthosis and inoculated at 25  DEG C. for three weeks.  The broth is clarified, passed through a bacteria-proof filter and a preservative added. Products having a deodorizing activity are obtained by adding chlorophyll or chlorophyll-containing vegetable material, e.g. spinach or beet leaves, to the culture medium.  The preparation may be incorporated in sprayable liquids, pastes, e.g. tooth pastes, chewing gum, tablets and ointments.ALSO:A preparation effective against diseases of the mouth cavity is obtained by inoculating a nutrient medium containing powdered unroasted green coffee beans, carbohydrates, a source of nitrogen and trace elements and having a pH of 5 to 7, with bacteria which in the form of saliva and/or smears have been taken from the mouth cavity of healthy humans or humans suffering from diseases of the mouth cavity and allowing the bacteria to grow under non-sterile conditions in surface or submerged culture at 18 DEG  to 28 DEG  C. and incorporating the culture broth, preferably after clarification, in a pharmaceutical carrier.  The preparation may be in the form of a sprayable liquid, a paste such as a tooth paste, chewing gum, tablets or ointment.  Chlorophyll or chorophyll-containing material, e.g. vegetable leaves, may be added to the culture broth to give deodorizing properties to the broth.
Pneumoperitoneum is typically a surgical emergency, particularly in children and more than 90% of occurrences are caused by perforation of the gastrointestinal tract and other hollow viscera. Wound infections after abdominal surgery are still frequent types of nosocomial infections. Sutures can be a source of wound infection and dehisence due to bacterial adherence and colonization. Sutures coated with antibacterial agents have been developed in an attempt to reduce bacterial adherence and colonization of suture materials. The objective of the study is to compare the outcome of antibiotic coated vicryl versus non-coated vicryl in abdominal fascial closure after laparotomy in children in regards of surgical site infections. It will be a randomized controlled trial in which 100 patients admitted in Children Hospital Lahore will be included. Simple random sampling will be carried out. Informed written consent will be taken from patients' guardian. The patients will be divided into two groups (50 in each group). Group-A patients will undergo laparotomy closure with antibiotic coated vicryl while Group-B patient will experience non-coated vicryl in abdominal fascial closure. All patients will be examined on 3rd, 7th and 30th post-operative day for wound infection according to Southampton wound scoring system. Data will be collected through predesigned proforma, which will be entered and statistically analyzed using SPSS version 24.0. For quantitative variables mean and standard deviation will be calculated and for qualitative variables frequency and percentages will be calculated. Data will be presented in tables and graphs. Chi-square test will be used to estimate the association between qualitative variables. P-value \<0.05 will be considered significant. It is expected that results of this study may be helpful for healthcare providers to provide appropriate treatment to the patients and to prevent them from wound related complications.
Dry powder formulations for inhalation, delivery systems, and methods of making and using thereof have been developed. The dry powder formulation contains particles containing (1) an antibody and/or an antibody derivative; and (2) a β-cyclodextrin and/or a β-cyclodextrin derivative. The total amount of the β-cyclodextrin and/or the β-cyclodextrin derivative is at least 50 wt%of the total amount of the antibody and/or antibody derivative and the β-cyclodextrin and/or β-cyclodextrin derivative. The particles of the dry powder formulation have favorable aerodynamic properties, e.g. mass median aerodynamic diameter < 5 μm, fine particle fraction > 40%in cascade impactor study, and emitted fraction >50%. The dry powder formulation can be prepared using spray-drying or spray-freeze-drying. Each administration of the dry powder formulation can deliver to a subject a unit dose of the antibody and/or antibody derivative to prevent, treat, or ameliorate symptom (s) associated with a respiratory disease in the subject.
Patients receive cabazitaxel IV over 60-90 minutes on day 1. Treatment repeats every 21 days for up to 10 courses in the absence of disease progression or unacceptable toxicity.
The invention discloses ferroferric oxide loaded compound micropowder and an application thereof in inhibiting the activity of tumor cells. The micropowder is in such a structure that Fe3O4 is used as a core which is surrounded by lanthanide elements-doped NaYF4, and the outer layer is wrapped by TiO2. The compound micropowder disclosed by the invention is good in particle dispersibility and uniform in grain size. The compound micropowder cannot only be used for acoustodynamic treatment for tumor, but also used for biomarker fluorescence imaging by photoluminescence, so that the disadvantageous characteristic that conventional particles can be used for tumor treatment but cannot be used for biomarker fluorescence imaging by photoluminescence, and the fluorescent probe can be used for biomarker fluorescence imaging by photoluminescence but cannot be applied to treating tumor is overcome. The micropowder disclosed by the invention is simple and quick in preparation method and low in cost, and fussy steps in the preparation process of multifunctional functions are avoided. In addition, the micropower disclosed by the invention is wrapped by TiO2, so that the micropower has monodisperse particles in exact structures, and the compound micropowder is more suitable for clinical application.
In this group all the patients perform a 1,5 Tesla RMI. With these data, three methods will be used to calculate the ADC score : Siemens, PACS Carestream, Osirix. The ADC scores obtained with these three post-processing softwares will be compared.
OBJECTIVE: Single-level selective dorsal rhizotomy (SDR), typically indicated for ambulatory patients, is a controversial topic for severe spastic cerebral palsy (CP) with Gross Motor Function Classification System (GMFCS) level IV or V. The objective of this case series and systematic literature review was to outline the indication and outcome of palliative SDR for nonambulatory patients with CP and GMFCS level IV and V, focusing on improvement of spasticity and of patient and caregiver reported quality of life assessment.
METHODS: A retrospective case series of patients with CP and GMFCS level IV or V who underwent single-level SDR at the authors' institution is presented. Furthermore, two databases (PubMed and Embase) were searched and a systematic review with a search string based on the terms "selective dorsal rhizotomy," "cerebral palsy," and "outcome" was conducted. The primary outcome was the reduction of spasticity based on the modified Ashworth scale (MAS). Secondary outcomes were change on the Gross Motor Function Measure-66 (GMFM-66), evaluation of patient-reported outcome measures (PROMs), surgical morbidity, and mortality.
RESULTS: Eleven consecutive children under the age of 25 years undergoing palliative single-level SDR were included. All patients showed a reduction in MAS score (mean 1.09 ± 0.66 points) and no surgical morbidity and mortality occurred. For the systematic review results from our case series, in addition to 4 reports, 274 total patients were included. Reduction of spasticity based on MAS score was noted in all studies (mean range 1.09-3.2 points). Furthermore, in 2 studies spasticity of the upper extremities showed a MAS score reduction as well (range 1.7-2.8 points). The GMFM-66 score improved in 72% of the patients, while bladder function improved in 78% of the patients. Based on the PROMs, 92% of the patients/caregivers were satisfied with the outcome and their quality of life after the procedure. Two wound infections (2.7%) and one CSF leak (1.3%) occurred, while no surgery-related deaths were described.
CONCLUSIONS: This analysis showed an improvement in spasticity, daily care, and comfort for patients with CP and GMFCS levels IV and V. Larger cohorts analyzing the outcome of palliative single-level SDR, based on the MAS, GMFM-66, and PROMs, are still needed and should be the focus of future studies. Systematic review registration no.: CRD42024495762 (https://www.crd.york.ac.uk/prospero/).
All patients admitted to a Swedish ICU with COVID-19 with at least one year of follow up. COVID-19 is defined by the International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) diagnosis U07.1 in the nationwide Swedish intensive care registry.
INTRODUCTION: Troponin elevation after noncardiac surgery is associated with an elevated risk of 30-day mortality. Little is known about relative merit of using a high-sensitivity Troponin T (hsTnT), the fifth-generation assay, vs the nonhigh sensitivity Troponin T (non-hsTnT), the fourth-generation assay, in the noncardiac surgery setting. We aimed to identify whether hsTnT can identify additional patients at risk that would have gone undetected with non-hsTnT measurement.
METHODS: The VISION Study included 40,004 noncardiac surgery patients with postoperative troponin measurements. Among them, 1,806 patients had both fourth-generation non-hsTnT and fifth-generation hsTnT concomitant measurements (4,451 paired results). We compared the absolute concentrations, the timing, and the impact of different thresholds on predicting 30-day major cardiovascular complications (composite of death, nonfatal cardiac arrest, coronary revascularization, and congestive heart failure).
RESULTS: Based on the manufacturers' threshold of 14 ng/L, 580 (32.1%) patients had postoperative hsTnT concentrations greater than the threshold, while their non-hsTnT concentrations were below the manufacturer's threshold. These 580 patients had higher risk of major cardiovascular events (OR 2.33; CI 95% 1.04-5.23; P = .049) than patients with hsTnT concentrations below the manufacturer threshold. Among patients with myocardial injury after noncardiac surgery, only 50% would be detected by the fourth-generation non-hsTnT assay at 6 to 12 hours postoperative as compared to 85% with the fifth-generation hsTnT assay (P-value < .001).
CONCLUSIONS: Within the first 3 postoperative days, fifth-generation hsTnT identified at least 1 in 3 patients with troponin elevation that would have gone undetected by fourth-generation non-hsTnT using published thresholds in this setting. Furthermore, fifth-generation hsTnT identified patients with an elevation earlier than fourth-generation non-hsTnT, indicating potential to improve postoperative risk stratification.
Have diagnosis of WS, between the ages of 5 and 70 years old. Be able to tolerate blood pressure measurements.