anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses an electronic delivery whiteboard for labor monitoring and a monitoring system thereof, which relate to the technical field of obstetrical monitoring and are technically characterized by comprising the following steps: and the data acquisition, analysis and display prenatal information and data dynamic evaluation module. The data acquisition module acquires multiple vital signs and delivery parameters of the mother and infant in real time through the sensor, the interface and the communication module. The data analysis module adopts an algorithm to analyze the data in real time, provides accurate results, and helps medical staff understand the mother and infant conditions. The prenatal information module acquires puerpera information through accessing the obstetrical information management system, and the assistance medical care knows the pregnancy history and high risk factors. The data dynamic evaluation module synthesizes vital signs and delivery parameters of the mother and infant, and displays the vital signs and the delivery parameters on the same interface in a chart form, so that medical staff can know the dynamic change of the data at the time of delivery, and a scientific basis is provided for decision making. The risk early warning module combines fetal monitoring, time-of-birth ultrasonic and electronic medical record data to implement fetal state assessment and risk prompt and provides comprehensive disease prediction and risk assessment.
Previously untreated patients on a CALGB treatment protocol for leukemia (acute or chronic) or myelodysplasia are eligible. Patients must be registered to CALGB 9665 prior to receiving any therapy for their disease.
The invention relates to an alkyl sulphate or an alkyl sulfonate, wherein the alkyl has a chain length greater than 11, for use in the treatment of a condition caused by, transmitted by and/or exacerbated by propionibacterial activity. Typically the condition is acne and the propionibacterium P. acnes. Preferred compounds have an alkyl chain length of 12 to 16, most preferably 14. Examples which show antibacterial activity against P. acnes include sodium tetradecyl(myristyl) sulfate (STS) and its hexadecyl and octadecyl analogues; sodium, ammonium or lithium dodecyl(lauryl) sulfate; sodium tetradecane sulfonic acid and its penta-, hexa- and octadecane analogues. The formulation is preferably topical, in the form of a cream, paste, gel, lotion, foam, ointment or varnish. Other conditions associated with propionibacteria that may be treatable using the invention include infections affecting the eye (endophthalmitis), wounds, burns, ulcers; and body odour. A method of controlling the growth of a propionibacterium by applying the alkyl sulphate or alkyl sulfonate of the invention to a non-living area or surface is also outlined.
PURPOSE: A composition and a functional food containing Mori Radicis Cortex ethanol extract are provided to suppress pancreatic cancer cell growth and to effectively prevent and treat pancreatic cancer. CONSTITUTION: A composition for preventing and treating pancreatic cancer contains Mori Radicis Cortex ethanol extract as an active ingredient, and pharmaceutically acceptable carriers or diluents. The extract is prepared by extracting Mori Radicis Cortex with 95% ethanol at 50 Deg. C. for 24 hours and drying and concentrating at 45 Deg. C. A functional food for preventing pancreatic cancer contains the extract as an active ingredient and sitologically acceptable food additives. [Reference numerals] (AA) Relative cell survival rate
Individuals were genotyped at the beginning of the study and their haplotypes were defined. Dichloroacetate 2.5.ug/kg (non-clinical dose) will be administered for five days in the clinical research center. On day 5 with the dose of DCA a pharmacokinetics test will be performed for 24 hours. 30 days later the individuals will return to the clinic and receive Dichloroacetate 25mg/kg (clinical dose) for five days. On day 1 and day 5 Pharmacokinetics will be performed to determine the relationship between DCA metabolism and haplotype.
BACKGROUND: Anterior displacement of the temporomandibular joint (TMJ) disc is the most typical pathological condition of TMJ disorders. Structures attached to the articular disc may support the disc in various directions and contribute to stabilizing the TMJ. However, the relationship between the articular disc, capsule, and masticatory muscles remains unclear. Therefore, this study aimed to clarify the relationship between the masticatory muscles, related masticatory fascia, articular disc, and capsule.
METHODS: We examined 10 halves from adult Japanese cadavers, with five halves macroscopically analyzed and the remaining five histologically analyzed. The TMJ was dissected from the lateral aspect for gross anatomical analysis. For histological analysis, the relationship between the temporal and masseteric fasciae and the articular capsule was observed in the coronal section. Additionally, we evaluated relationships among the disc, capsule, temporal fascia, and masseteric fascia in 10 living and healthy volunteers using magnetic resonance imaging.
RESULTS: The articular disc was attached to the capsule without a clear border. The capsule continued into the masseteric and temporal fasciae. Consequently, the articular disc, capsule, masseteric, and temporal fasciae were considered a single complex.
CONCLUSIONS: The single complex of the temporalis, masseter, capsule, masticatory fascia, and disc may antagonize the force in the posterolateral direction through the fascia.
Thyroid Associated Ophthalmopathy is one of autoimmune orbital diseases characterized by enlargement of the extraocular muscles and increase in fatty or/and orbit connective tissue volume affecting the appearance and visual function of the eyes. Different degrees of exophthalmos, eyelid aperture, lid retraction and lid lag are common symptoms apprearing in TAO. The improvement of exophthalmos is usually measured with Hertel instrument and the change of eyelid is measured with millimeter ruler. All these measurements are subjective, low reliable and less accurate.

TAO can be classified into active phase and inactive phase according to the activity score and wait-and-see or surgery are widely chosen for patients in inactive phase. But still a progression and reoccurrence can be a big challenge for ophthalmologists. This is a perspective cohort study to evaluate the efficacy of doxycycline in TAO by multi-model image.
BACKGROUND: Acinetobacter baumannii is an opportunistic pathogen that can cause a variety of nosocomial infections in humans. This study aimed to molecularly characterize extended-spectrum beta-lactamase (ESBL) producing and carbapenem-resistant Acinetobacter species isolated from surgical site infections (SSI).
METHODS: A multicentre cross-sectional study was performed among SSI patients at four hospitals located in Northern, Southern, Southwest, and Central parts of Ethiopia. The isolates were identified by microbiological methods and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Antibiotic susceptibility was determined using disk diffusion. The presence of phenotypic ESBL and carbapenemase production was detected by employing standard microbiological tests, including combined disk diffusion (CDT). ESBL and carbapenem resistance determinants genes were studied by polymerase chain reaction (PCR) and sequencing.
RESULTS: A total of 8.7% Acinetobacter species were identified from 493 culture-positive isolates out of 752 SSI wounds. The species identified by MALDI-TOF MS were 88.4% A. baumannii, 4.7% Acinetobacter pittii, 4.7% Acinetobacter soli, and 2.3% Acinetobacter lactucae. Of all isolates 93% were positive for ESBL enzymes according to the CDT. Using whole genome sequencing 62.8% of the A. baumannii harbored one or more beta-lactamase genes, and 46.5% harbored one or more carbapenemase producing genes. The distribution of beta-lactamases among Acinetobacter species by hospitals was 53.8%, 64.3%, 75%, and 75% at JUSH, TASH, DTCSH, and HUCSH respectively. Among ESBL genes, blaCTX-M alleles were detected in 21.4% of isolates; of these 83.3% were blaCTX-M-15. The predominant carbapenemase gene of blaOXA type was detected in 24 carbapenem-resistant A. baumannii followed by blaNDM alleles carried in 12 A. baumannii with blaNDM-1 as the most common.
CONCLUSIONS: The frequency of Acinetobacter species that produce metallobetalactamases (MBLs) and ESBLs that were found in this study is extremely scary and calls for strict infection prevention and control procedures in health facilities helps to set effective antibiotics stewardship.
Prompt institution of appropriate regimens for care of the burned patient is of prime importance and includes the control of shock and pain. The burn wounds are then cleansed and debrided; Silver Sulfadiazine Cream is then applied under sterile conditions. The burn areas should be covered with Silver Sulfadiazine Cream at all times. The cream should be applied once to twice daily to a thickness of approximately one sixteenth of an inch. Whenever necessary, the cream should be reapplied to any areas from which it has been removed due to patient activity. Administration may be accomplished in minimal time because dressings are not required. However, if individual patient requirements make dressings necessary, they may be used. Reapply immediately after hydrotherapy. Treatment with Silver Sulfadiazine Cream should be continued until satisfactory healing has occurred or until the burn site is ready for grafting. The drug should not be withdrawn from the therapeutic regimen while there remains the possibility of infection except if a significant adverse reaction occurs.
Two parts e.g. 1, 10 to be welded by electron bombardment are machined to provide each with two contact surfaces 35, 36, the parts are then assembled so that a vacuum seal 2 is clamped between one pair of contact surfaces 36, a leak tight enclosure 6 is established around the other contact surfaces 35 and an electron gun 7 caused to travel along the line of the second surfaces 35 to weld the parts together on these surfaces, the vacuum seal 2 remaining imprisoned after welding is completed. The electron gun is supported on an arm 8 which carries high and low voltage supplies, coolant and optical connections for weld viewing, the arm 8 passing through a seal 47 and bearings 46 in a casing 42. A further seal 44 connects the casing 42 to the part 1 and a plug 4 completes the enclosure 6 which is evacuated through a connection 5. Rotary motion of the gun is derived from a motor 13 or hand wheel while longitudinal movement may also be effected by a hand wheel (not shown). The vacuum seal may be held in a channel in one of the parts to be welded, in a chamfered corner between the parts or in two channels in a further member disposed outside the two parts to be joined (Figs. 3-10, not shown). The electron gun (Fig. 2, not shown) includes in addition to the cathode (14, 17) and anode (20) arrangement a focussing coil (21) coolant passages (12, 22) and a mirror (23) for viewing of the weld region.
FIELD: medicine. SUBSTANCE: method involves determining level of IgG antibodies to glucuronoxylomann in patient blood serum. High level of antibodies shows infection manifestations or latent infection availability. Titers of antibodies to glucuronoxylomann being greater than 1:10, indicate high risk of cryptococcosis infection. Method involves using a kit for determining availability of antibodies to glucuronoxylomann containing solid phase, hydrophobic ligand, indicator enzyme system and substratum. The ligand provides hydrophobic linking of glucuronoxylomann to the solid phase. EFFECT: enhanced effectiveness in preventing the disease. 6 cl, 14 dwg, 2 tbl
BACKGROUND: Chordoma, a rare bone tumour with aggressive local invasion and high recurrence rate with limited understanding of its molecular mechanisms. Circular RNAs (circRNAs) have been extensively implicated in tumorigenesis, yet their involvement in chordoma remains largely unexplored. N6-methyladenosine (m6A) modification holds a crucial function in regulating protein translation, RNA degradation and transcription.
METHODS: Initially, screening and validation of circTEAD1 in chordoma were conducted by high-throughput sequencing. Subsequently, sh-circTEAD1 and an overexpression plasmid were constructed. Colony formation assays, cell counting kit-8, Transwell and wound healing assays were utilized to validate the function of circTEAD1 in vitro. RNA pull-down assays identified the binding proteins of circTEAD1, which underwent verification through RNA immunoprecipitation (RIP). Methylated RIP assays were conducted to detect the m6A binding sites. Following this, luciferase assay, RT-qPCR, RIP and Western blotting analyses were conducted, revealing that Yap1 was the direct target of circTEAD1. Afterwards, the same methods were utilized for the validation of the function of Yap1 in chordoma in vitro. Finally, the regulatory relationship between circTEAD1 and Yap1 in chordoma was verified by an in vivo tumour formation assay.
RESULTS: CircTEAD1 was identified as an upregulated circRNA in chordoma specimens, with heightened circTEAD1 expression emerging as a prognostic indicator. In vitro experiments convincingly demonstrated that circTEAD1 significantly promoted chordoma cell invasion, migration and aggressiveness. Furthermore, the analysis revealed that methyltransferase-like 3-mediated m6A modification facilitated the cytoplasmic export of circTEAD1. The circTEAD1/IGF2BP3/Yap1 mRNA RNA-protein ternary complex not only bolstered the stability of Yap1 mRNA but also exerted a pivotal role in driving chordoma tumorigenesis.
CONCLUSIONS: In this study, the role of m6A-modified circTEAD1 in chordoma was identified. The findings offer novel insights into the potential molecular targets for chordoma therapy, shedding light on the intricate interplay between circRNAs, m6A modification and Yap1 mRNA in chordoma pathogenesis.
This descriptive study sponsored by the United States Department of Defense involves the examination of TBI participants and normal control participants through MRI (Without Contrast) scanning. Normal controls are essential to develop a statistically sound range for the metrics derived from High Definition Fiber Tracking (HDFT). TBI subjects will undergo 1 MRI scan and normal controls will be asked to undergo 1 MRI scan. The study will involve blinded evaluations of results to determine the ability of HDFT imaging methods to evaluate TBI.

In addition to the TBI and normal controls evaluated in this research study, investigators will be running 30 pilot participants. These participants will be undergoing MRI in order to streamline our pulse sequence and calibrate the MRIs. This is part of the technical development for the project and will occur before the recruitment of TBI subjects and normal controls for comparison. Data from the pilot subjects will not serve as control data for the TBI subjects.
Targeted therapies are the standard first-line treatment for metastatic lung adenocarcinoma with certain molecular abnormalities. These abnormalities are particularly common in Southeast Asia and French Polynesia. A 51-year-old Tahitian female non-smoker was diagnosed in 2018 with stage IV lung adenocarcinoma harboring a p.L858R EGFR mutation. She received gefitinib as first-line treatment. Due to locoregional progression and the presence of a resistance mutation (p.T790M of EFGR), she received osimertinib as second-line treatment, after which chemotherapy was proposed as 3rd-line treatment. An additional biopsy detected not only the previously known EGFR mutation, but also a BRAF p.V600E mutation. Following disease progression during chemotherapy, the patient received targeted therapies combining dabrafenib, trametinib and osimertinib. Due to a dissociated response after four months of treatment, a 5th line of paclitaxel bevacizumab was initiated. Subsequent to additional progression and given the ALK rearrangement shown on the re-biopsy, 6th-line treatment with alectinib was proposed. As the response was once again dissociated, a final line was proposed before stopping active treatments due to their toxicity and overall deterioration in the patient's state of health. This exceptional case is characterized by resistance to anti-EGFR through the successive and cumulative acquisition of two new oncogene addictions. The authors underline the importance of re-biopsy at each progression, leading (if at all feasible) to yet around round of targeted therapy.
A method of treatment of mental disorder of a subject includes the steps of: normalizing an expression of both DRD1 and DRD5, which belong to DRDl-like family, of the subject to a preset standard level. The DRD1/5 level and expression can be increased or decreased bidirectionally by targeting an upstream promoter sequence of DRD1/5. The promoter activity of DRD1/5 can be attenuated by using an antipsychotic which directly targets the DRD1/5 promoter. The antipsychotics being used are typical and/or atypical antipsychotic medications such as Haloperidol, Risperidone, Clozapine and Cariprazine. The treatment is also useful for the subject with an impaired constitutive expression of DRD1/5 gene. The method can be used to treat schizophrenia, autism, depression, mania and bipolar disorders by normalizing the DRD1/5 expression level. The promoter gene sequencing of DRD1 and/or DRD5 can also be used for quantitative mental health screening through comparing with a standard sequence database.
Described herein are assistant robots that anticipate needs of one or more people (or animals). The assistant robots may recognize a current activity, knowledge of the person's routines, and contextual information. As such, the assistant robots can provide or offer to provide appropriate robotic assistance. The assistant robots can learn users' habits or be provided with knowledge regarding humans in its environment. The assistant robots develop a schedule and contextual understanding of the persons' behavior and needs. The assistant robots may interact, understand, and communicate with people before, during, or after providing assistance. The robot can combine gesture, clothing, emotional aspect, time, pose recognition, action recognition, and other observational data to understand people's medical condition, current activity, and future intended activities and intents.
Thirty participants will receive injections in the following order: NYVAC-B for injections one and two, placebo for injection three, and rAd5 for the fourth and final injection. Two participants in this group will receive placebo vaccines only.
INTRODUCTION: Older Black adults are at risk of cerebral small vessel disease (CSVD), which contributes to dementia risk. Two subtypes of CSVD, arteriolosclerosis and ischemic lacunar infarcts, have been independently linked to lower cognition and higher dementia risk, but their combined effects on cognition in older Black adults are unclear.
METHODS: Mixed models were used to examine the associations of in vivo measures of arteriolosclerosis (ARTS) and ischemic lacunar infarcts to cognitive level and change in 370 older Black adults without dementia.  RESULTS: Modeled together, higher ARTS load accounted for lower levels of global cognition, episodic memory, semantic memory, and perceptual speed, whereas higher infarct load accounted for lower levels of working memory. There were no associations with rate of cognitive change.
DISCUSSION: Both arteriolosclerosis and ischemic infarcts impact the cognitive health of older Black adults, but arteriolosclerosis affects cognition more broadly and offers promise as an in vivo biomarker of dementia risk.
HIGHLIGHTS: Older Black adults are at risk of cerebral small vessel disease (CSVD) and dementia. Examined magnetic resonance imaging-derived measure of arteriolosclerosis (ARTS), infarcts, and cognition. ARTS load was widely associated with lower cognition after adjusting for infarct load. Infarct load was specifically associated with lower complex attention. More within-Black in vivo studies of CSVD subtypes and cognition are needed.
A head-mounted device, such as augmented reality glasses, can be configured to track screen time by capturing an eye image of an eye of a user using an eye-tracking camera, analyzing the eye image to identify a screen reflection, starting a screen timer after the screen reflection is identified, and periodically capturing subsequent eye images to track the screen reflection over time, stopping the screen timer when the screen reflection can no longer be tracked; and recording a screen time of a first instance based on the screen timer. The head-mounted device can advantageously track screen time across a variety of devices whether or not they are configured to such measurements. Various modes for tracking the screen time including an eye-tracking camera and/or a front facing camera may be used based on accuracy, power consumption, and privacy. The head-mounted device may track in a mode based on a battery level, a device setting or a user input. The head-mounted device may accumulate screen times in a database and in some implementations, can link screen times with devices in the database based on device information gathered by the head-mounted device during the tracking process. The head-mounted device may be configured to generate and display an alert based on one or more rules about screen time.
INTRODUCTION: No published evidence was identified regarding the use of oxygen in the treatment of drowning in two recent systematic reviews. The aim of our study was to investigate the impact of on scene, pre-Emergency Medical Services (EMS) oxygen therapy by lifeguards in the resuscitation of drowning victims.
METHOD: We conducted a retrospective case match analysis of drowning patients presenting to the EDs of Sunshine Coast Hospital and Health Service. Patients were matched for age, sex and severity of drowning injury. The primary outcome was in-hospital mortality. Secondary outcomes included positive pressure ventilation (PPV) by EMS and the ED, as well as admission to the Intensive Care Unit.
RESULTS: There were 108 patients in each group. Median (IQR) age was 22 (15-43) in the oxygen group and 23 (15-44) years in the non-oxygen group. There were 45 females in the oxygen group and 41 females in the non-oxygen group. Sixteen patients had suffered cardiac arrest and three patients respiratory arrest in each group. There were five deaths in each group. Initial oxygen saturation on arrival of EMS was identical in both groups 89.2% (±19.9) in the oxygen group versus 89.3% (±21.1) (P = 0.294) in the non-oxygen group. The oxygen group required PPV more frequently with EMS (19 vs 11, P < 0.01) and in the ED (19 vs 15, P < 0.01).
CONCLUSION: On scene treatment with oxygen by lifeguards did not improve oxygenation or outcomes in drowning patients.