anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This is a phase 1, open-label, strain and dose-finding study designed to establish a human challenge model for CS17+ ETEC that causes \> 80% attack rate without causing high output diarrhea. Based on the strain histories, testing will commence using LSN03-016011/A. This strain was isolated from a naïve adult U.S. citizen living in Turkey with a typical clinical presentation for ETEC diarrheal disease and no bacterial co-pathogens isolated from the stool. The host is representative of the study population for this study and for future efficacy studies with anti-CS17+ ETEC vaccines. As shown in the figure below, 5x108 cfu of ETEC strain (LSN03-016011/A) will initially be administered to 5 subjects. If an attack rate of \>80% (at least 4/5 subjects) occurs with no high output diarrhea, results will be confirmed in an additional 10 subjects. Additionally, an inoculum at least ½ log lower (1x108) (depending on the severity of illness documented) may be administered to 10 subjects to characterize the dose-response relationship. If the 5x108 cfu inoculum does cause high output diarrhea, then the inoculum will be reduced appropriatelyIf the 5x108 cfu of LSN03-016011/A does not cause a \> 80% attack rate, the next step will depend on the observed attack rate and severity of illness. A low attack rate with mild disease would prompt a change to the alternate strain (WS7688A) for testing, using the same pathway used with the LSN strain . An attack rate \< 80% with most diarrhea classified as at least moderate diarrhea would prompt an upward adjustment of the LSN inoculum appropriate to the findings. The decision to move up or down in inoculum or to change CS17 + strains will only occur with the concurrence of the medical monitor. Following each step in the strain and dose finding iterations, a report summarizing the results of that step, and detailing the planned next step will be signed by the principal investigator and the medical monitor. The maximum dose of either strain is 1 X 109. The anticipated maximum number of subjects planned for this study is 25.

Subjects will be admitted to the inpatient facility on study day -1. On study day 0, subjects will have their morning meal, fast for 90 minutes, and then be given 120mL of sodium bicarbonate buffer to neutralize stomach acidity. Approximately one minute later they will ingest the appropriate dose and strain (either LSN03-016011/A or WS6788A ) of CS17+ ETEC diluted in 30mL sodium bicarbonate buffer. Doses of the challenge inoculum will be prepared by one of the study staff microbiologists. Treatment with antibiotics will start on study day 5, or earlier if criteria for early antibiotic treatment are fulfilled. Subjects will be discharged when they feel well and have 2 consecutive stool cultures negative for CS17+ ETEC.

For each group of 5 study subjects, the study period will include the screening period, one month for the inpatient and outpatient phases, and six-months for the final phone check. The study period, accounting for the serial scheduling of multiple groups of 5, processing immunology specimens, study analysis and report writing, is 1 ½ years.
The invention relates to the technical field of biological medicine. The invention provides an application of IMMU-132 in preparing a medicament for treating colorectal cancer. The invention provides an application of IMMU-132 in preparing a medicament for treating colorectal cancer primary focus tumor. The invention provides an application of IMMU-132 in preparing a medicament for treating drug-resistant colorectal cancer primary focus tumor. The invention provides an application of IMMU-132 in preparing a medicament for treating colorectal cancer liver metastasis. The invention provides an application of IMMU-132 in preparing a medicament for treating drug-resistant colorectal cancer liver metastasis. The invention provides an application of IMMU-132 in preparing a CRC cell inhibition medicament. The invention provides a medicament for treating colorectal cancer, wherein the effective component of the medicament is IMMU-132. The invention develops the application of IMMU-132 in the CRC treatment targeting medicine, which is hopeful to help solve the difficulty of obtaining drug resistance after clinical CRC systemic treatment.
Iron and zinc are important micronutrients for cognitive development and growth in children, particularly during infancy when brain development and physical growth are rapid. Iron and zinc deficiencies likely coexist in young children in poor developing countries due to high requirements for these micronutrients at this age, low consumption of animal products (which are rich sources of these nutrients) and similar problems of poor bioavailability from plant foods. One would expect that iron and zinc supplementation in infancy would be an appropriate strategy to promote long-term cognitive development and school achievement, but this has never been evaluated. We have many studies of the effects on micronutrient interventions in infancy but the benefits of these interventions have been assessed only in terms of outcomes in infancy. What are missing are studies of micronutrient interventions during the critical phase of infancy that report effects measured in school children and beyond. Only then will we begin to understand the full impact of micronutrient interventions in infancy on human function. From 1998 to 1999, a randomized, placebo controlled trial of iron and zinc supplementation was carried out in 609 4-6 month-old infants in Khon Kaen province, Thailand. Infants were randomized to four groups (zinc, iron, iron and zinc, placebo) and those supplemented received 10 mg of iron and/or 10 mg of zinc daily for 6 months. Improvements in iron and zinc status and in ponderal growth were found; no measures of cognitive development in infancy were included. We propose a follow-up study of these children at ages 8 to 10 years. From February to July 2006, we conducted a pilot study and were able to locate 584 or 96% of the sample. The children are all in school and we propose to assess schooling, cognitive performance (Wechsler test adapted to Thailand) and language and mathematical skills. In addition, data on physical growth, biochemical status, dietary intakes and socioeconomic status will be collected. We expect that knowledge from this study will be useful for properly assessing the full benefits of improving iron and zinc status in early childhood.
An aerosol propellant formulation consists of at least 65% by weight of volatile chlorofluorinated paraffinic hydrocarbon or hydrocarbons having a normal boiling point not greater than 30 DEG  C., the remainder comprising at least one of the C3, C4, C5 and C6 paraffins and including at least one of the C5 and C6 paraffins, the total amount of C3 and C4 paraffins when present not exceeding 16% by weight of the chlorofluorinated hydrocarbon. Examples are given of air-fresheners, fly-sprays and a hair lacquer. Specification 885,746 is referred to.ALSO:Aerosol fly-spray compositions comprise active ingredients, solvents and propellants.  In one example, a composition comprises pyrethrum extract, piperonyl butoxide, odourless kerosene, emulsifier, perfume, water, isopropanol, hexane and dichlorodifluoromethane.  Examples also relate to a hair lacquer and air-freshness.  Specification 885,746 is referred to.
The invention discloses a novel silicon-phenanthroline derivative, a method for preparing the compound and application thereof. The compound takes a silicon atom as a core, takes phenanthroline or a derivative thereof and 4,4 '-dinonyl-2, 2' -bipyridyl as a coordination structure, and has the following structure: r is hydrogen, alkyl (methyl, ethyl) or aryl (phenyl, tolyl or ethylphenyl). The structural compound can form stable salt with inorganic acid or organic acid. The preparation method of the silicon-phenanthroline derivative is simple and feasible and is suitable for expanded production. Has antibacterial effect on bacteria such as Staphylococcus aureus and Escherichia coli, and fungi such as Cryptococcus and Candida albicans. The compound can be accepted by pharmacyThe carrier or excipient of (1) is prepared into antibacterial and/or antifungal medicines.
This group is composed by 20 ALS subjects under 600mg valproate and 600 mg of litium carbonate per day, during 21 months. The tablets are given orally with meals.
AIMS: Creutzfeldt-Jakob disease (CJD) is a lethal neurodegenerative disorder, which leads to a rapidly progressive dementia. This study aimed to examine the cortical alterations in CJD, changes in these brain characteristics over time, and the differences between CJD and Alzheimer's disease (AD) that show similar clinical manifestations.
METHODS: To obtain reliable, subject-specific functional measures, we acquired 24 min of resting-state fMRI data from each subject. We applied an individual-based approach to characterize the functional brain organization of 10 patients with CJD, 8 matched patients with AD, and 8 normal controls. We measured cortical atrophy as well as disruption in resting-state functional connectivity (rsFC) and then investigated longitudinal brain changes in a subset of CJD patients.
RESULTS: CJD was associated with widespread cortical thinning and weakened rsFC. Compared with AD, CJD showed distinct atrophy patterns and greater disruptions in rsFC. Moreover, the longitudinal data demonstrated that the progressive cortical thinning and disruption in rsFC mainly affected the association rather than the primary cortex in CJD.
CONCLUSIONS: CJD shows unique anatomical and functional disruptions in the cerebral cortex, distinct from AD. Rapid progression of CJD affects both the cortical thickness and rsFC in the association cortex.
Clinical studies of verapamil did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Aging may affect the pharmacokinetics of verapamil. Elimination half-life may be prolonged in the elderly (See CLINICAL PHARMACOLOGY, Pharmacokinetics and Metabolism).

Verapamil is highly metabolized by the liver, and about 70% of the administered dose is excreted as metabolites in the urine. Clinical circumstances, some of which may be more common in the elderly, such as hepatic or renal impairment, should be considered (See PRECAUTIONS, General). In general, lower initial doses of Verapamil Hydrochloride Sustained-Release Capsules may be warranted in the elderly (See DOSAGE AND ADMINISTRATION).
PROBLEM TO BE SOLVED: To prepare an unemulsified type water-based skin cosmetic, having synergistically enhanced preventing actions on skin aging and excellent in skin beautifying effects by formulating an extract from a specific plant with one or more water-soluble polymers. SOLUTION: This skin cosmetic is prepared by formulating an extract from a plant belonging to the genus Betula of the family Betulaceae and/or an extract from a plant belonging to the genus Alnus of the same family with one or more water-soluble polymers selected from natural water-soluble polymers and semisynthetic water-soluble polymers Betula platyphylla var. japonica, Betula platyphylla var. platyphylla, Betula pendula, etc., are especially preferred as the plant. The amount of the formulated extract is 0.001-10wt.% based on the total amount of the cosmetic. Xanthan gum, carrageenan, guar gumm, etc., are preferred as the water-soluble polymer and the amount thereof formulated is 0.001-5.0wt.%.
The developmental origins of obesity begin in utero with growth and differentiation of adipose tissue. Fetal white adipose tissue accretion is highly variable and dependent on the maternal intrauterine environment. Unlike white adipose tissue, brown adipose tissue has a high capacity for thermogenesis. Brown adipose tissue is present at birth and it is believed to support the critical function of thermoregulation in early postnatal life. Therefore, Brown adipose tissue may also influence the development of neonatal energy balance. Similar to white adipose tissue, it is hypothesized that development of Brown adipose tissue in utero is also influenced by maternal factors such as prepregnancy body mass index and gestational weight gain. The research aims of this study to 1) identify maternal and neonatal factors that contribute to neonatal Brown adipose tissue and 2) to identify changes in neonatal Brown adipose tissue and to energy expenditure in response to a mild cold exposure. To achieve these aims, we will conduct a cross-sectional, observational study in up to 60 infants 0-3 weeks of age. Using state-of-the-art methodology, we will assess brown adipose tissue, body composition, and resting metabolic rate under thermoneutral and mild-cold stimulated conditions.
Methods to form an active agent modified monomer comprising a ring opening cyclic monomer linked to an active agent via a degradable covalent linkage. Methods to form a polymer or copolymer comprising an active agent modified monomer.  Methods to form an active agent modified monomer comprising combining a ring opening cyclic monomer with a first functional group (X) and an active agent with a second functional group (Y) to form an active agent modified monomer, wherein the first (X) and second (Y) functional groups are complementary functional groups that form a degradable linkage. The active agent modified monomer can also comprise a non-degradable linkage. The method can form a ring opening cyclic monomer that includes a cyclic carbonate, cyclic epoxide, lactam, lactone, lactide anhydride, cyclic carbamate, cyclic phosphoester, or siloxane. Apparatus that includes a medical device that comprises a polymer or copolymer that comprises an active agent modified monomer.
Five selected MII will undergo sequential polar biopsy; on day 0 \[PB1\] (36-42 hours post trigger injection) and if fertilization occurred on day 1 \[PB2\] (17-20 hours post ICSI). On day 5, 6 or 7, the resulting blastocyst will be biopsied.
The magnetic resonance imaging (MRI) is useful to diagnose soft tissue morphology, especially to detect cancer and disk displacement with temporomandibular disorders. The prevalence of tongue cancer may increase with ageing population. A clear MR image is indispensable for clinical diagnosis. However, tongue motion associated with the habitual or swallowing tongue movement may cause artifacts on MRI. This occurrence of motion artifact is speculated to be prominent with the patients without the occlusal support. The objective of this pilot study was to compare level of artifact while tongue at rest and in motion of dentulous subjects.
A method for applying electromagnetic wave and ultrasonic wave therapies is provided. According to the method, a material simulating a living tissue is applied and pressed onto a surface of a human body so that the material is intimately contacted with the body surface with substantially no spaces present therebetween. Electromagnetic or ultrasonic wave is generated and irradiated to the body through the material. The material comprises a hydrogel having a high water content. The hydrogel is prepared by the steps of casting an aqueous polyvinyl alcohol solution into a mold, cooling the cast aqueous solution to obtain a cooled frozen mass and thawing the cooled frozen mass. The cooling and thawing steps may be repeated up to eight cycles. The hydrogel is also prepared by subjecting the cooled frozen mass to a partial dehydration step in vacuum.
Determine in healthy, adequately pyridoxine nourished humans using a protocol based on amino acid glycine tracer methods: (a) the postprandial rates of in vivo glycine turnover, glycine-based generation of one-carbon units, thymidylate and purine synthesis, and the impact of vitamin B6 deficiency on the rates of these processes and (b) the effect of vitamin B6 deficiency on the postprandial rate of glutathione synthesis. 14 subjects will be chosen after screening is complete and will begin a B6 deficient diet for 30 days. At the beginning and end of the 30 days they will receive an infusion of leucine and glycine then they will begin the four week diet. At the end of four weeks the infusion will be repeated.
This study examined the multiple-deficit hypothesis among Arabic-speaking elementary school students. A total of 90 students, divided into three main groups based on their performance on an Arabic word-reading task: dyslexic (n = 30), regular age-matched (n = 30), and 3rd-grade regular students, who were matched to the dyslexic group in regard to their reading proficiency level (n = 30). Participants underwent a nine-domain Arabic reading experiment that measured accuracy and fluency to evaluate general reading proficiency. The performance of Arabic dyslexic students was significantly worse than age-matched controls, but similar to young matched controls based on the reading level of each cognitive task. Moreover, dyslexic students showed deficits in three or more cognitive functions, depending on severity. This study adds to the limited empirical research on the double-deficit hypothesis and its extension to the multiple-domain model among young Arabic students.
Cosmetic use of an active ingredient comprising sugar obtained from Adenophora strictain a cosmetic composition as skin depigmenting agent, is claimed. Independent claims are included for: (1) the depigmenting agent obtained from Adenophora stricta, having a sugar content of >= 30%; (2) a process for obtaining the agent comprising solubilization of the Adenophora strictaroots in aqueous medium and enzymatic hydrolysis; and (3) a cosmetic composition for topical application on the skin having depigmenting effect, comprising the agent at 0.1-25%. ACTIVITY : Dermatological. MECHANISM OF ACTION : Rab27a synthesis inhibitor; Melanophilin synthesis inhibitor; Melanin synthesis inhibitor; Tyrosinase inhibitor. The ability of the active ingredient from Adenophora strictato inhibit the synthesis of melanophilin was tested in normal human melanocyte cultures using Western blot. The result showed that the active ingredient of the Adenophora strictadecreased 34% of synthesis of melanophilin.
BACKGROUND: Tuberculous sepsis is uncommon in individuals without human immunodeficiency virus (HIV) infection, and some patients may not exhibit clinical signs and symptoms of suspected sepsis upon admission, leading to delayed diagnosis and treatment.
CASE PRESENTATION: This report present the case of a 60-year-old female patient who presented with erythema, edema, and pain in her right upper limb accompanied by fever and chills. Further evaluation revealed multiple intermuscular abscesses caused by suspected gram-positive bacteria. Despite receiving anti-infection treatment, the patient rapidly progressed to septic shock and respiratory failure. Metagenomic next-generation sequencing (mNGS) analysis of blood samples detected Mycobacterium tuberculosis complex groups (11 reads). Additionally, mNGS analysis of fluid obtained from puncture of the abscess in the right upper extremity also suggested Mycobacterium tuberculosis complex groups (221 981 reads). Consequently, the patient was diagnosed with tuberculous sepsis resulting from hematogenous dissemination of Mycobacterium tuberculosis. Following the administration of anti-tuberculosis treatment, a gradual recovery was observed during the subsequent follow-up period.
CONCLUSION: It is noteworthy that atypical hematogenous disseminated tuberculosis can be prone to misdiagnosis or oversight, potentially leading to septic shock. This case illustrates the importance of early diagnosis and treatment of tuberculosis sepsis. Advanced diagnostic techniques such as mNGS can aid clinicians in the early identification of pathogens for definitive diagnosis.
LPG; pregnant women who will undergo emergency C-section with labor pain. Labor pain will be defined as having 3 or more regular uterine contractions in 20 minutes or \>120 Montevideo units of uterine performance observed during non-stress testing (NST) conducted at the Obstetrics Clinic.
FIELD: chemistry. ^ SUBSTANCE: invention relates to compounds of formula (I) in form of base or a pharmaceutically acceptable addition salt with an acid. The disclosed compounds have -amyloid peptide(-A4) formation inhibiting properties. In formula (I), R1 denotes: C1-6-alkyl or phenyl; where said phenyl groups are substituted with two substitutes selected from halogen atoms; R1 and R2' independently denote a hydrogen atom or a hydroxy group; R3 denotes C1-6-alkyl; one or another of radicals R4 and R5 is a group Z and one or another of radicals R4 and R5 is a -C(X)R6 group; G denotes a single bond; Y denotes a single bond, an oxygen atom, a sulphur atom, a C1-4-alkylene group; A and B independently denote a hydrogen atom, a halogen, trifluoromethyl, trifluoromethoxy group; provided that if Y denotes a single bond or an oxygen atom and if group Z is a type group, A does not denote a hydrogen atom; X denotes an oxygen atom; R6 denotes a C1-6alkoxy group. The invention also relates to a method for synthesis of formula (I) compounds, to a medicinal agent and a pharmaceutical composition based on said compounds, and to use of formula (I) compounds in preparing the medicinal agent. ^ EFFECT: increased effectiveness of using said derivatives. ^ 6 cl, 1 tbl, 31 ex
Matching placebo to BGS649 (0.3 and 0.1mg). 0.3mg placebo capsule given on Day 1 and 0.1mg placebo capsule on other treatment visits (week 1 to 11).
Hybrid methods are a suitable option for extracting dietary patterns associated with health outcomes. This study aimed to identify the dietary patterns of Brazilian adults (20-59 years old; n = 28,153) related to dietary components associated with the risk of obesity. Data from the 2017-2018 Brazilian National Dietary Survey were analyzed. Food consumption was obtained through 24 h recall. Dietary patterns were extracted using partial least squares regression, using energy density (ED), percentage of total fat (%TF), and fiber density (FD) as response variables. In addition, 32 food groups were established as predictor variables in the model. The first dietary pattern, named as energy-dense and low-fiber (ED-LF), included with the positive factor loadings solid fats, breads, added-sugar beverages, fast foods, sauces, pasta, and cheeses, and negative factor loadings rice, beans, vegetables, water, and fruits (≥|0.15|). Higher adherence to the ED-LF dietary pattern was observed for individuals >40 years old from urban areas, in the highest income level, who were not on a diet, reported away-from-home food consumption, and having ≥1 snack/day. The dietary pattern characterized by a low intake of fruits, vegetables, and staple foods and a high intake of fast foods and sugar-sweetened beverages may contribute to the obesity scenario in Brazil.