anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain the titled polysaccharide useful as an antitumor agent simply in a large scale, by extracting bark of Melia azadirachata Linn. with hot water, purifying the extracted solution by dialysis membrane method, etc., bringing it into contact with specific dextran gel, collecting it from the contacted aqueous solution. CONSTITUTION:Bark of Melia azadirachata Linn is extracted with hot water, the extracted solution is purified by dialysis membrane method, alcohol precipitation method, or ultrafiltration. The prepared extracted solution is brought into contact with crosslinked dextran gel having 700-5,000 upper limit of fractionated molecular weight range and <=100 lower limit, and polysaccharide N9GI (lyophilized polysaccharide N9GI is white powder or light yellowish brown powder; soluble in water, insoluble in an organic solvent such as methanol, etc.; positive in phenol sulfuric acid reaction, etc. and addition of iodine shows blue green) is obtained from he contacted aqueous solution. The dextran gel used as an adsorbent is preferably required to have improved mechanical strength, and high crosslinking.
Example embodiments provide techniques for managing and resolving failed glaucoma drainage devices (GDDs). In example embodiments, these techniques require only a simple office or minor-operating room procedure. For example, a GDD may fail due to a fibrous capsule forming about the plate portion of the GDD and preventing aqueous flowing through the tube of the GDD from the anterior region from leaving the encapsulated bleb area. The failed GDD may be made to function effectively again, in an example embodiment, by placing and/or implanting a stent implant into the wall of the fibrous capsule to allow aqueous to flow through the stent into the subconjunctival space. According to an aspect of the present invention, a method for treating a failed GDD is provided. In an example embodiment, the method comprises placing a stent implant in the wall of the capsule surrounding a posteriorly placed episcleral plate of the GDD.
<P>PROBLEM TO BE SOLVED: To provide a snore preventing composition which gives anions originated from tourmaline to a nostril, a neck part, etc. to suppress a snore.  <P>SOLUTION: This snore preventing composition is snore preventing tourmaline mineral powder for using snore preventing effect by bringing the composition directly or indirectly in contact with the skin, and is specified by mixing powdered tourmaline mineral as the effective component into the base material of an external skin drug. A base in a cream form, gel form, lotion form, or milky lotion form is used as the base material. A tourmaline mineral is powder with 2-300 micron of the average particle diameter. The tourmaline mineral is brought in directly or indirectly contact with the skin to use the snore preventing effect as a snore preventing method.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
Subjects undergoing elective endovascular catheterization for coiling of unruptured cerebral aneurysms. Four blood draws of 5mL each: (1) prior to initiation of procedure; (2) at the time of catheterization of major cerebral vessels, (3) immediately after the procedure, and (4) 24-hours after the procedure.
214,238. Squibb & Sons, E. R., (Assignees of Nitardy, F. W.). April 9, 1923, [Convention date]. Void [Published under Sect. 91 of the Act]. Preserving cod-liver oil &c.-Food substances rich in vitamine A, such as cod-liver oil, are packed in vessels, the air in which is replaced by inert gas such as carbon dioxide or nitrogen to prevent the destruction of the vitamine by oxidation. To ensure the complete expulsion of air a drum may be completely filled with oil, a portion of which is then expelled by the inert gas, the drum being then sealed. The oil may be filtered in an atmosphere of inert gas, and the bottles in which it is sold filled with such gas, particularly carbon dioxide, above the oil.
PURPOSE:To prepare the title perfume which masks iron rust odor effectively and maintains its quality for a long time by incorporating at least one perfume selected from the group consisting of a natural essential oil derived from citrus fruits, methylionone, and limonene into the title perfume. CONSTITUTION:The title perfume contains at least one perfume selected from the group consisting of a natural essential oil derived from citrus fruits (e.g. lemon oil or orange oil), methylionone, and limonene. The title perfume, if necessary together with a general perfume, is mixed with a polyvalent metal salt soln. (e.g. a soln. of ferrous sulfate or ferric chloride) to give a polyvalent metal salt compsn. The compsn. is combined with an org. compd. which reacts with the compsn. to develop a color (e.g. ethyl gallate), giving a hairdye. The title perfume, besides capable of effectively masking iron rust odor, maintains its quality for a long time even in the presence of a general perfume or a cationic surfactant, and the hairdye does not give the hair dyed an unpleasant iron rust odor.
<P>PROBLEM TO BE SOLVED: To provide a prodrug of a class of sulfonamides which is an aspartyl protease inhibitor.  <P>SOLUTION: This invention relates to a new class of prodrugs of HIV aspartyl protease inhibitors characterized by favorable water solubility, high oral bioavailability and facile in vivo generation of the active ingredient. This invention also relates to a pharmaceutical composition comprising these prodrugs. The prodrugs and pharmaceutical compositions of this invention are particularly well suited for decreasing the pill burden and increasing patient compliance. This invention also relates to a method of treating mammals with these prodrugs and pharmaceutical compositions.  <P>COPYRIGHT: (C)2009,JPO&INPIT
BACKGROUND: Hemolysis is a cardinal feature of hemolytic uremic syndrome (HUS) and during hemolysis excess arginase 1 is released from red blood cells. Increased arginase activity leads to reduced L-arginine, as it is converted to urea and L-ornithine, and thereby reduced nitric oxide bioavailability, with secondary vascular injury. The objective of this study was to investigate arginase release in HUS patients and laboratory models and correlate arginase levels to hemolysis and kidney injury.
METHODS: Two separate cohorts of patients (n = 47 in total) with HUS associated with Shiga toxin-producing enterohemorrhagic E. coli (EHEC) and pediatric controls (n = 35) were investigated. Two mouse models were used, in which mice were either challenged intragastrically with E. coli O157:H7 or injected intraperitoneally with Shiga toxin 2. An in vitro model of thrombotic microangiopathy was developed in which Shiga toxin 2- and E. coli O157 lipopolysaccharide-stimulated human blood cells combined with ADAMTS13-deficient plasma were perfused over glomerular endothelial cells. Two group statistical comparisons were performed using the Mann-Whitney test, multiple groups were compared using the Kruskal-Wallis test followed by Dunn's procedure, the Wilcoxon signed rank test was used for paired data, or linear regression for continuous variables.
RESULTS: HUS patients had excessively high plasma arginase 1 levels and activity (conversion of L-arginine to urea and L-ornithine) during the acute phase, compared to remission and controls. Arginase 1 levels correlated with lactate dehydrogenase activity, indicating hemolysis, as well as the need for dialysis treatment. Patients also exhibited high levels of plasma alpha-1-microglobulin, a heme scavenger. Both mouse models exhibited significantly elevated plasma arginase 1 levels and activity. Plasma arginase 1 levels correlated with lactate dehydrogenase activity, alpha-1-microglobulin and urea levels, the latter indicative of kidney dysfunction. In the in vitro model of thrombotic microangiopathy, bioactive arginase 1 was released and levels correlated to the degree of hemolysis.
CONCLUSIONS: Elevated red blood cell-derived arginase was demonstrated in HUS patients and in relevant in vivo and in vitro models. The excessively high arginase levels correlated to the degree of hemolysis and kidney dysfunction. Thus, arginase inhibition should be investigated in HUS.
The present invention relates to a system for remote patient monitoring. The system comprises at least one medical device, a patient remote device, a remote monitoring server device (RMS), and a health care professional (HCP) remote device. The at least one medical device is configured to automatically collect physiological data of a patient and transmit the collected physiological data of the patient to the RMS via the patient remote device. The RMS is configured to interface with the HCP remote device via a healthcare professional interface comprising a web-based portal and/or an app-based portal to allow a health care professional to access the collected physiological data of the patient on the RMS. In this way, it is possible to provide continuous remote monitoring of physiological data from a medical implant with no patient interaction required. The monitoring data is available to physicians via web-based and/or app-based user portal on-demand. The RMS may provide frequent (e.g. daily) automatic reporting of physiologic measurements e.g. sleep impairment, activity levels, core temperature for fever (e.g. potential infections).
Stroke patients have various problems such weight. The loss of motion element involved on ﬁne functions, and the above-mentioned problems can lead to decreased muscle cooperativity of the lower limbs while walking and may also result in an asymmetric gait due to imbalance in the ability to perform exercises. Recent studies on the treatment of stroke patients reported that approaches such as more intensive and repetitive training as compared to conventional general and passive intervention, training related to reality, intervention involving motivation and active participation and forced induction exercise, visual exercise feedback, purpose-oriented training, and task-oriented training are more effective in promoting function after stroke onset. Virtual reality (VR) is frequently used in different disease groups at the clinic for rehabilitation purposes. Xbox Kinect, Nintendo Wii, Sony PlayStation, and Cyber Glove are among the most commonly used VR applications in rehabilitation. Several studies reported that VR applications improved both upper and lower extremity functions and promoted independence in performing activities of daily living.

Games based on virtual reality for stroke rehabilitation are mainly focused on motor rehabilitation. Nevertheless, interest in the integration of cognitive and motor rehabilitation has grown. Research shows that the use of virtual reality-based games improves the range of motion as well as the memory and attention of stroke patients. Benefits of virtual reality games include diverse and intensive exercises, designing exercises tailored to patients' abilities, monitoring patients' progress, and boosting patients' motivation. Game-based virtual reality is an emerging technology in healthcare allowing users to interact with a dynamic 3D environment. Studies show that this technology is an effective, feasible and safe solution which makes rehabilitation more convenient. In addition, computer games increase motivation, satisfaction and involvement of patients.
INTRODUCTION: Incidental gallbladder carcinoma refers to a discovery of gallbladder cancer during or after cholecystectomy. Late port-site metastasis (PSM) following Laparoscopic cholecystectomy (LC) is rare with an incidence rate of 10.3%.
PATIENT CONCERNS: We report a case of a 58-year-old man who presented with a painful abdominal wall mass for 6 weeks. He had a history of LC for symptomatic cholelithiasis, 8 years prior.
DIAGNOSIS: Histopathological examination revealed a positive result for metastatic adenocarcinoma from the abdominal wall mass. Moreover, Positron emission tomography (PET) showed a small focus of intense fluorodeoxyglucose (FDG) uptake in the gallbladder bed, which was highly suspicious for malignancy.
INTERVENTION: Decision was to proceed with surgery owing to uptake in the gallbladder bed with single-site metastasis to the previous port site. In addition, in the board meeting, an agreement was reached for performing distal pancreatectomy with splenectomy owing to uncertainty of malignancy based on what was discovered during the full metastatic workup. Diagnostic laparoscopy followed by midline laparotomy performed. Radical completion cholecystectomy with lymphadenectomy was done. Followed by complete resection of the anterior abdominal wall. Distal pancreatectomy and splenectomy were then performed.
OUTCOME: Pathological diagnosis showed metastatic/invasive, moderately differentiated adenocarcinoma with positive margins on the posterior surface of excised port-site mass. The positive margins necessitated further chemoradiotherapy, followed by adjuvant chemotherapy until lung metastasis was identified. After this, the patient was scheduled for palliative chemotherapy.
CONCLUSION: Presence of PSM is often associated with peritoneal metastasis. For this reason, it is advised to evaluate the patient for possible metastasis.
The alpha subunits of hemoglobin, which in nature are formed as separate polypeptide chains which bind noncovalently to the beta subunits, are here provided in the form of the novel molecule di-alpha globin, a single polypeptide chain defined by connecting the two alpha subunits either directly via peptide bond or indirectly by a flexible amino acid or peptide linker. Di-alpha globin may be combined in vivo or in vitro with beta globin and heme to form hemoglobin. Di-alpha globin is expressed by recombinant DNA techniques. Di-beta globin may be similarly obtained. We further describe the production of tetrameric human hemoglobin and di-alpha/beta2 hemoglobin in the yeast Saccharomyces cerevisiae. The synthesis of the protein is directed by a synthetic promotor consisting of two functional parts, an upstream activator sequence (UAS) that confers inducible transcription by galactose from a consensus yeast transcriptional initiation site. The expression construct is designed such that translation is expected to initiate at the same position as the human wild-type genes for  alpha - and  beta -globin. Three different types of expression vectors have been used: (1)  alpha -globin and  beta -globin contained on two separate plasmids (pGS4688 and pGS4988) in a diploid yeast strain; (2)  alpha -globin and  beta -globin each contained on a single plasmid (pGS289 and pGS389) and expressed in either haploid or diploid strains; and (3) di-alpha-globin and beta globin contained on a single plasmid (pGS 3089)and expressed in haploid strains. Finally, we describe the co-expression of alpha and beta globin chains. The chains are folded together and combined intracellularly with heme to form active tetrameric hemoglobin. The hemoglobin may be recovered from the cells' soluble fraction. The invention thus obviates the need to express alpha and beta globin separately, solubilize, renature and purify them, and combine them in vitro with heme to obtain an artificial hemoglobin. By way of comparison, the separately expressed beta globin known in the art is deposited in inclusion bodies. Polycistronic co-expression of alpha and beta globins is particularly preferred.
This study aimed to determine the characteristics of accelerations and angular velocities obtained by an inertial measurement unit (IMU) attached to a cane between older people with and without physical frailty. Community-dwelling older people walked at a comfortable speed using a cane with a built-in IMU. Physical frailty was assessed using exercise-related items extracted from the Kihon Check List. The efficacy of five machine learning models in distinguishing older people with physical frailty was investigated. This study included 48 older people, of which 24 were frail and 24 were not. Compared with the non-frail participants, the older people with physical frailty had a small root mean square value in the vertical and anteroposterior directions and angular velocity in the anteroposterior direction (p < 0.001, r = 0.36; p < 0.001, r = 0.29; p < 0.001, r = 0.30, respectively) and a large mean power frequency value in the vertical direction (p = 0.042, r = 0.18). The decision tree model could most effectively classify physical frailty, with an accuracy, F1 score, and area under the curve of 78.6%, 91.8%, and 0.81, respectively. The characteristics of IMU-attached cane usage by older adults with physical frailty can be utilized to effectively evaluate and determine physical frailty in their usual environments.
OBJECTIVES: Early prediction of epileptic seizures can help reduce morbidity and mortality. In this work, we explore using electrocardiographic (ECG) signal as input to a seizure prediction system and note that the performance can be improved by using selected signal processing techniques.
METHODS: We used frequency domain analysis with a deep neural network backend for all our experiments in this work. We further analysed the effect of the proposed system for different seizure semiologies and prediction horizons. We explored refining the signal using signal processing to enhance the system's performance.
RESULTS: Our final system using the Temple University Hospital's Seizure (TUHSZ) corpus gave an overall prediction accuracy of 84.02 %, sensitivity of 87.59 %, specificity of 81.9 %, and an area under the receiver operating characteristic curve (AUROC) of 0.9112. Notably, these results surpassed the state-of-the-art outcomes reported using the TUHSZ database; all findings are statistically significant. We also validated our study using the Siena scalp EEG database. Using the frequency domain data, our baseline system gave a performance of 75.17 %, 79.17 %, 70.04 % and 0.82 for prediction accuracy, sensitivity, specificity and AUROC, respectively. After selecting the optimal frequency band of 0.8-15 Hz, we obtained a performance of 80.49 %, 89.51 %, 75.23 % and 0.89 for prediction accuracy, sensitivity, specificity and AUROC, respectively which is an improvement of 5.32 %, 10.34 %, 5.19 % and 0.08 for prediction accuracy, sensitivity, specificity and AUROC, respectively.
CONCLUSIONS: The seizure information in ECG is concentrated in a narrow frequency band. Identifying and selecting that band can help improve the performance of seizure detection and prediction.
SIGNIFICANCE: EEG is susceptible to artefacts and is not preferred in a low-cost ambulatory device. ECG can be used in wearable devices (like chest bands) and is feasible for developing a low-cost ambulatory device for seizure prediction. Early seizure prediction can provide patients and clinicians with the required alert to take necessary precautions and prevent a fatality, significantly improving the patient's quality of life.
BACKGROUND: Fatty livers are widely accepted as marginal donors for liver transplantation but are more susceptible to liver ischemia and reperfusion (IR) injury. Increased macrophage-related inflammation plays an important role in the aggravation of fatty liver IR injury. Here, we investigate the precise mechanism by which endoplasmic reticulum (ER) stress activates macrophage NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) signaling by regulating mitochondrial calcium overload in fatty liver IR.
METHODS: Control- and high-fat diet-fed mice were subjected to a partial liver IR model. The ER stress, mitochondrial calcium levels, and NLRP3 signaling pathway in macrophages were analyzed.
RESULTS: Liver steatosis exacerbated liver inflammation and IR injury and enhanced NLRP3 activation in macrophages. Myeloid NLRP3 deficiency attenuated intrahepatic inflammation and fatty liver injury following IR. Mechanistically, increased ER stress and mitochondrial calcium overload were observed in macrophages obtained from mouse fatty livers after IR. Suppression of ER stress by tauroursodeoxycholic acid effectively downregulated mitochondrial calcium accumulation and suppressed NLRP3 activation in macrophages, leading to decreased inflammatory IR injury in fatty livers. Moreover, Xestospongin-C-mediated inhibition of mitochondrial calcium influx decreased reactive oxygen species (ROS) expression in macrophages after IR. Scavenging of mitochondrial ROS by mito-TEMPO suppressed macrophage NLRP3 activation and IR injury in fatty livers, indicating that excessive mitochondrial ROS production was responsible for macrophage NLRP3 activation induced by mitochondrial calcium overload. Patients with fatty liver also exhibited upregulated activation of NLRP3 and the ER stress signaling pathway after IR.
CONCLUSIONS: Our findings suggest that ER stress promotes mitochondrial calcium overload to activate ROS/NLRP3 signaling pathways within macrophages during IR-stimulated inflammatory responses associated with fatty livers.
The investigated product mGlobal L+AS was applied by intradermal or subcutaneous injection by the investigator during Session 1 for all subjects and Session 2 for the subjects, for whom a touch-up was considered beneficial. Both sessions were conducted within 14 day intervals.
In order to solve the problem that no efficient special drying equipment exists in the existing mask production process, the utility model develops a mask product microwave dryer. The method comprises the following steps: the device comprises a belt transmission device 1, a microwave drying unit 2, a microwave anti-overflow device 3, a dosing device and a dehumidifying device 5. There may be one or more microwave drying units 2. The microwave drying unit 2 comprises a shell, a microwave generator 21 positioned at the top of the shell and an observation window 22 positioned in the middle of the shell. The microwave anti-overflow device 3 includes a housing and a microwave absorbing plate 31. The medicine adding device comprises a pipeline system 41 and a spray head 42. The dehumidifying apparatus 5 includes a blower 51, a header pipe 52, and branch pipes 53 extending into each microwave drying unit 2. The microwave drying equipment of the utility model is provided with the microwave anti-overflow device, which prevents the microwave from leaking out of the drying cavity and causing damage to the health of workers; a dosing system is also added.
Patients receive tanespimycin IV over 2-6 hours on days 1, 4, 8, and 11. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
FIELD: medicine. SUBSTANCE: solution contains at least one osmotically active ingredient selected from acetylated amino sugar, deacetylated amino sugar, or their combinations. The agent is taken as monomer or oligomer having 2 to 12 carbohydrate links. N- acetylgalactosamine, N-acetylglucosamine, N-acetylmannosamine, glucosamine, galactosamine, mannosamine are usable as the agent. The solution optionally contains electrolytes like Na, Cl, Ca, Mg, lactate, malate, acetate, succinate, or their combinations. It has pH of 5.0-7.4. Method for performing peritoneal analysis involves introducing the solution into the peritoneal cavity. Method for treating the patient on the occasion of renal insufficiency involves introducing the solution into the peritoneal cavity of the patient. EFFECT: improved biocompatibility properties; avoided morphological or functional disorders of the peritoneal membrane; prolonged period of treatment. 28 cl, 2 tbl
IDA 10mg/M2 per day, D1-3. iv. injection in 10mimutes;Ara-C：100-200mg/M2 per day, D1-7. administration advice: at first, 25 mg/M2 of Ara-C is given by fast intravenous injection, then 100 mg/M2 of Ara-C is given by continuous iv drip for 24 hours for successive 7 days.