anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Atractylenolide III (ATL III) is a natural bioactive compound, that possesses anti-inflammatory, antioxidant, and neuroprotective properties. However, whether ATL III can protect against neuronal injury induced by cerebral ischemia/reperfusion (I/R) have not yet been studied. This study aimed to investigate the protective effects of ATL III on neuronal injury using an oxygen-glucose deprivation/reperfusion (OGD/R) model in HT22 cells.
METHODS: Establishment of OGD/R model to induce HT22 cell injury in vitro. Cell viability, live-dead cell staining, oxidative stress levels, and pro-inflammatory cytokine levels were detected using kits. Cell apoptosis was observed by flow cytometry, and the expression of Bax, Bcl-2, and Caspase-3 proteins was detected by western blot.
RESULTS: ATL III significantly alleviates OGD/R-induced cell injury, as evidenced by the increased cell viability and reduced apoptosis rate. ATL III increased the levels of superoxide dismutase (SOD) and glutathione (GSH), while reducing malondialdehyde (MDA), reactive oxygen species (ROS), and the levels of TNF-α, IL-1β, and IL-6. The protein expression of Bax and Caspase-3 was downregulated, while Bcl-2 expression was upregulated by ATL III.
CONCLUSION: ATL III as a potential therapeutic agent for reducing neuronal injury by mitigating oxidative stress, apoptosis, and inflammation.
The proposed study aims to explore the relationships between perceived uncertainty, hope and adaptation in caregivers of children with Down Syndrome (DS). There are often uncertainties surrounding the prognosis of DS which extend into various aspects of the child s life. In addition to the possibility of chronic medical conditions associated with the syndrome, there is also uncertainty related to the level of independence and cognitive, social and behavioral functioning that the child will achieve. It is not fully understood how caregivers adapt to having a child with DS in light of the uncertainty and the particular challenges associated with this condition. While a high level of perceived uncertainty may be seen as a threat to adaptation, there is also evidence that caregivers may find benefits in uncertainty. Literature suggests that a person s level of hope influences how the perceived uncertainty is appraised and that hope is also related to the process of adaptation. There is no research that systematically explores the relationship between perceived uncertainty, hope, and adaptation. This study s conceptual framework is based on Lazarus \& Folkman s Transactional Model of Stress and Coping and is also informed by Snyder s conceptualization of hope and Mishel s theory of perceived uncertainty in illness. A cross-sectional research design will quantitatively explore the relationships between perceived uncertainty, hope, and adaptation. In addition, an open-ended section will be included to qualitatively describe the focus of caregivers hope for their child and how the focus of hope relates to the degree of hope. Participants will be recruited from DS support groups, website postings, listservs, and clinic patient lists. They will have the option of completing either a paper or online version of the survey, or completing the survey by phone. The main outcome variable is psychological adaptation to being a care giver for a child with DS.
A weight management system for managing vehicle seat occupant body weight by using vehicle cameras and weight sensors of a plurality of vehicles having onboard communication modules. Each vehicle is equipped to analyze and compare weight changes of the vehicle seat occupant over time. Based on the weight status, a weight management recommendation can be transmitted to the vehicle seat occupant. Each vehicle is operatively connected to a weight management application in a data center. The weight management application includes a registration module which registers each vehicle. Additionally, a vehicle seat occupant may register with the weight management application to have his/her weight analyzed when travelling in any of the plurality of vehicles. The weight management application requests a search of a data lake and analysis of search results by a weight data artificial intelligence analytics program to improve the weight management recommendation.
The utility model relates to an order arrangement feeding device for capsules, which is an improvement on the feeding device with different specifications for capsules; the inside of the feeding device is filled with the capsules with powders and granules in different specific weight. The utility model comprises machine frames, a hopper, a post, a capsule conveying comb, a capsule pressing comb, a capsule comb, and a capsule conveying switch. The same plane of the capsule comb is additionally provided with a capsule pushing comb, and the machine frame is provided with a rotary shaft. The rotary shaft is provided with a shifting fork body. One end of the shifting fork body is connected with the capsule pushing comb, and the other end of the shifting fork body is connected with the capsule conveying comb. The utility model solves the problem that the feed of the capsule is in random arrangement for a packaging device of a bubble cap, realizes the synchronizing purpose of capsule conveying and capsule pressing, and is suitable to the packaging of the medicine industry, the food industry, the light industry, etc.
PURPOSE: A composition containing hinokitiol for preventing and/or treating ischemic diseases is provided to suppress PHD2 activation and to effectively stabilize HIF-1 alpha. CONSTITUTION: An angiogenesis promoter contains hinokitiol of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. A composition for preventing or treating ischemic diseases contains hinokitiol of chemical formula 1 or pharmaceutically acceptable salt thereof. The administration amount is 0.1-100 mg/kg a day. A health food composition for preventing or treating ischemic diseases contains hinokitiol of chemical formula 1 or pharmaceutically acceptable salt thereof. The health food composition is used as beverage, gum, tea, health supplementary food, food additives in the form of powder, granules, tablet, or capsule.
PURPOSE: Our study aimed to assess the oncological outcomes of sentinel node dissection during radical prostatectomy according to nodal location in comparison to extended pelvic lymph node dissection.
MATERIALS AND METHODS: Prospectively collected data of clinically node-negative patients who underwent prostatectomy and extended lymph node dissection with or without sentinel node from January 2013 to January 2023 were retrospectively analyzed. The primary end point was to assess oncological outcomes on the whole population. Kaplan-Meier curves were used to depict biochemical and clinical recurrence-free survival. Multivariable Cox regression models assessed the impact of nodal location on single-photon emission computed tomography on oncological outcomes. Adjustment for case mix included: pathological T stage, ISUP (International Society of Urological Pathology) grade group, initial PSA, nodal burden, age at surgery, and surgical margin status. Secondarily, a propensity score match was performed according to age at surgery, PSA, biopsy ISUP, clinical T stage, and Briganti risk of nodal invasion. Survival and regression analyses were also performed in the matched population.
RESULTS: Of the patients, 55.8% had at least 1 sentinel node outside of lymph node dissection template at single-photon emission computed tomography/CT. Log-rank test showed comparable 36-month biochemical (P = .3) and clinical recurrence-free survival (P = .6) among patients with sentinel node inside template, outside template, or extended pelvic lymph node dissection alone. At Cox regression, sentinel node location outside template was associated with lower hazard of metastases (HR 0.62; P = .04) in the overall cohort, while in the matched cohort benefits were observed only for biochemical recurrence (HR 0.57; P = .001).
CONCLUSIONS: Wider nodal resection boundaries outside the "classic" template, driven by sentinel node procedure, have a positive impact on oncological outcomes in selected patient.
The Pentacam Classic (Oculus Optikgerate GmbH, Heidelberg, Germany, software version 1.14r04) was used for the sake of the study.Three study groups were formed: 1) Normal 2) Keratoconus group (KC) included patients with progressive keratoconus and 3) Collagen-Cross-linking group (CXL) included keratoconus patients that had been treated with uneventful CXL at least on year prior to their enrollment in the study.

Three consecutive scans were obtained by two experienced operators. The same procedure was repeated within two weeks for the assessment of intersession variability. In all cases acceptable maps had at least 10.0mm of corneal coverage. Keratometry (K), asphericity (Q), best-fit toric ellipsoid radius (Rs), eccentricity (ecc) and aberrometry (6.0mm pupil diameter), were analyzed. Furthermore we calculated and studied CRMS and CLRMS in order to better appreciate the visual significance of HOAs. Precision (Pre), repeatability (COR) and intraclass correlation coefficient (ICC), were calculated for evaluating intrasession and intersession repeatability. Bland-Altman analysis was used for assessing interobserver repeatability.
Subjects randomized to the levalbuterol arm will complete 1 of 6 possible randomization sequences containing (a) levalbuterol 45 µg (1 actuation of 45 µg); (b) levalbuterol 90 µg (2 actuation of 45 µg) and (c) levalbuterol 180 µg (4 actuations of 45 µg each). Subjects will receive treatment, according to the randomization sequence, followed by a 5±2 day washout.
INTRODUCTION: When ventricular tachycardia (VT) recurs after standard RF ablation (sRFA) some patients benefit from repeat sRFA, whereas others warrant advanced methods such as intramural needle ablation (INA). Our objectives are to assess the utility of repeat sRFA and to clarify the benefit of INA when repeat sRFA fails in patients with VT due to structural heart disease.
METHODS: In consecutive patients who were prospectively enrolled in a study for INA for recurrent sustained monomorphic VT despite sRFA, repeat sRFA was considered first. INA was performed during the same procedure if repeat sRFA failed or no targets for sRFA were identified.
RESULTS: Of 85 patients enrolled, acute success with repeat sRFA was achieved in 30 patients (35%), and during the 6-month follow-up, 87% (20/23) were free of VT hospitalization, 78% were free of any VT, and 7 were lost to follow-up. INA was performed in 55 patients (65%) after sRFA failed, or no endocardial targets were found abolished or modified inducible VT in 35/55 patients (64%). During follow-up, 72% (39/54) were free of VT hospitalization, 41% were free of any VT, and 1 was lost to follow-up. Overall, 59 out of 77 (77%) patients were free of hospitalization and 52% were free of any VT. Septal-origin VTs were more likely to need INA, whereas RV and papillary muscle VTs were less likely to require INA.
CONCLUSIONS: Repeat sRFA was beneficial in 23% (18/77) of patients with recurrent sustained VT who were referred for INA. The availability of INA increased favorable outcomes to 52%.
No data are available regarding methazolamide overdosage in humans as no cases of acute poisoning with this drug have been reported. Animal data suggest that even a high dose of methazolamide is nontoxic. No specific antidote is known. Treatment should be symptomatic and supportive.

Electrolyte imbalance, development of an acidotic state, and central nervous system effects might be expected to occur. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored. Supportive measures may be required to restore electrolyte and pH balance.
FIELD: medical equipment. 
     SUBSTANCE: group of inventions relates to a system for screening delirium in a patient, a system for screening and threshold treatment of delirium, a system for recognizing electronic medical records for screening delirium in a patient. Patient’s delirium screening system comprises a portable screening device. Screening device comprises two sensors, a processor and a module. Sensors are configured to register one or more brain signals indicative of brain wave frequencies. Module is configured to compare frequencies of brain waves over time, performing spectral density or signal shape analysis for brain wave frequencies, establishing and/or changing a threshold ratio by means of electronic medical records, comparing said ratio with said threshold ratio, changing and updating the threshold ratio over time, outputting data. Spectral density or signal shape is analyzed to establish the ratio of densities of brain waves of high frequency with brain waves of low frequency. High-frequency brain waves are higher than 7.5 Hz and low-frequency brain waves are lower than 7.5 Hz. Derived data represent an indicator of presence, absence or probability of further development of delirium based on comparison of the specified ratio with the specified threshold ratio. System for screening and threshold treatment of delirium comprises a portable screening device and a module. Portable device comprises a housing and less than five sensors. Sensors are configured to register brain signals indicative of brain wave frequencies. Module is configured to collect brain wave frequencies over time from sensors, performing spectral density analysis for brain wave frequencies, establishing and/or changing the threshold ratio of patient data by means of electronic medical records, comparing said ratio with said threshold ratio of patient data, outputting data. Derived data represent an indicator of the presence, absence or probability of subsequent development of delirium or encephalopathy based on comparison of said ratio with said threshold ratio of patient data. System for recognizing electronic medical records for screening delirium in a patient comprises a portable screening device, two sensors, a processor, a database and program modules. Database contains patient data. Software modules comprise a signal processing module, a validation module, a threshold module and an analysis module. Threshold module is configured to set a delirium threshold. Analysis module is configured to perform spectral density analysis for brain wave frequencies. Delirium threshold is configured to be set by a machine learning module, working with patient data from electronic medical records. 
     EFFECT: providing higher accuracy and reliability of screening delirium and encephalopathy in a patient. 
     17 cl, 13 dwg
AIMS: Significance of peribiliary capillary plexus (PCP) in gallbladder neoplasms remains unclear. Aims are to characterize high-grade biliary intraepithelial neoplasm (BilIN), pyloric gland adenoma (PGA), and intracholecystic papillary neoplasm (ICPN), precursors of gallbladder carcinoma, and to differentiate invasive carcinoma from pseudo-invasive lesions in gallbladder walls, referring to PCP.
MATERIALS AND METHODS: High-grade BilIN (38 cases), PGA (5 cases), and ICPN (25 cases) were examined using capillary immunostaining. Non-neoplastic gallbladders were used as controls.
RESULTS: In non-neoplastic gallbladders, a single layer of regularly dotted capillaries (PCP) was located beneath lining epithelia and around non-neoplastic glands (NNGs), including Rokitansky-Aschoff sinus (RAS), presenting a two-layer of lining epithelia and PCP. Intra-luminal components of all cases of high-grade BilIN and PGA and one-third of ICPNs presented a two-layer pattern. In the remaining ICPNs, capillaries were irregular and sparse in intraluminal neoplastic components presenting irregular and complicated lesions. Neoplastic glands in gallbladder walls of high-grade BilIN and ICPN were classifiable into 2 types: glands that were underlain by densely dotted capillaries and those that were not, with the latter suggestive of invasive carcinoma, while the former suggestive of non-invasive neoplasms involving NNGs intraepithelially and/or showing an expanding growth into gallbladder wall (pseudo-invasion).
CONCLUSION: A two-layer pattern of lining epithelia and underlining capillaries were preserved in all cases of high-grade BilIN and PGA and one-third of ICPN cases. Presence or absence of dotted capillaries around neoplastic glands may be able to be added as a new pathologic feature to differentiate invasive carcinomas from pseudo-invasion in gallbladder wall.
Participants are required to visit the lab twice. In the first visit, participants will first perform a verbal fluency task during which the brain activity will be recorded by fNIRS. Then participants complete a cognitive test called Raven's Advanced Progressive matrices (\~ 40 min). In the second visit, participants will receive concurrent iTBS/fNIRS.
Patient is intubated with etomidate 0.1\~0.2mg/kg and rocuronium 1mg/kg. 30 minutes after rocuronium administration, patient is administered sugammadex 1mg/kg. Glasgow coma scale as neurologic assessment is assessed at 10-minute intervals before intubation, and at 5-minute intervals up to 30 minutes after administration of sugammadex. After 30 minutes, the assessments are conducted at 10-minute intervals. Additionally, if the patient spontaneously opens their eyes, the GCS is assessed at that specific moment. The GCS evaluation continues until the patient reaches a point of responsiveness, indicated by a Motor score of 6 on the GCS.
Osteopenia is characterized by bone mineral density (BMD) being lower than normal but not reaching the osteoporosis threshold, poses a serious problem for women after menopause. Osteopenia is a precursor to osteoporosis that is associated with increased risk of fractures, morbidity, and mortality. Using strategies to improve or maintain bone density is important for preventing osteoporosis and its associated complications. The combination of collagen peptide (CP) with calcium and vitamin D supplementation may provide several ways to improve bone health. This study aims to provide preliminary evidence of the effectiveness of traditional medicine in improving bone health through the effectiveness of CP.The study was single blinded randomized controlled trial, involving 30 post-menopausal women that were equally divided into two groups by computer generated simple random sampling technique. Group A received bioactive collagen peptide along with calcium lactate, and vitamin D3. The control group (Group B) consisted of 15 participants who were given a chewable tablet daily, containing 1.25 grams of calcium carbonate (equivalent to 500 mg of elemental calcium) and 400 IU of vitamin D3.
Gliclazide will be initiated and maintained at 30mg/ day every morning until the completion of the study. Meanwhile, all patients will also continue on their existing dose and regimen of metformin throughout the study. Visits at 4-week intervals will be performed to evaluate the safety of drugs. Metformin dose can be reduced in response to hypoglycaemia, but Gliclazide could not be adjusted. If the plasma glucose still not achieve the target at the maximum dose, the maximum dose will be maintained until the completion of the study.
The invention relates to a Chinese medicinal combination for treating piglet severe diarrhea. The Chinese medicinal combination consists of the following components in parts by weight: 1-11 parts of baical skullcap root, 3-13 parts of Indian buead, 3-13 parts of umbellate pore fungus, 1-9 parts of cyrtomium rhizome, 1-11 parts of dried orange peel and 1-10 parts of cassia bark. Each Chinese medicinal component of the Chinese medicinal combination for treating piglet severe diarrhea is fine powder. The Chinese medicinal combination is prepared with boiled water and taken with warm water once every day, and is taken continuously for 2-3 days. The using amount of the Chinese medicinal combination is determined for a piglet of which the weight is 25 kilograms, and can be increased or decreased considerably according to the weight of the piglet. The Chinese medicinal combination is mainly used for clearing away heat and toxic materials, relieving diarrhea and thickening bowels, and has the advantages of simple compatibility of medicines, simple preparation method, low cost, safety and reliability. After the Chinese medicinal combination is taken, the symptoms of a sick piglet are quickly relieved, the sick piglet recovers quickly, and a remarkable curative effect is achieved.
The invention generally is related to preventing or inhibiting microbial infections on live tissues or in relation to the use of medical articles. In one embodiment, the invention is directed to a method for forming an antimicrobial coating on live tissue or a medical article, such as, for example, a catheter. The method includes applying to a live tissue or a surface of a medical article an aqueous or non-aqueous composition that includes at least one silane of the general formula R 1   n Si(OR 2 ) 4-n  wherein, n is an interger of 1 or 2, R 1  generally is a lower alkyl group, a C 6 -C 8  aryl group, or a functional group, such as vinyl, acrylic, amino, mercapto, or vinyl chloride functional group, and R 2  generally is a lower alkyl group. A partial condensate of a silanol of the formula R 1 Si(OH) 3  also can be used. The composition includes one or more additional ingredients. The method also includes reacting and/or curing the silane, in the presence of the one or more ingredients, thereby forming the antimicrobial coating.
PROBLEM TO BE SOLVED: To obtain an active oxygen scavenger originated from a neutral product, high in safety and useful as a component of a health food having an active oxygen scavenging activity by adding an extract of matico. SOLUTION: This scavenger contains an extract of matico. Matico is a plant of Piperaceae Piper, and the plant body or its crushed product (either raw or dried material) can be used for the extraction. A method for obtaining the extract comprises, for example, suitably crushing a dried product of leaves, stems, buds or the like of matico as the raw material, and subsequently extracting the crushed product with water, alcohol, a hydrated alcohol or the like. The active oxygen scavenger contains the obtained extract of matico, for example, in an amount of 0.001-100 (w/w)%, preferably 0.01-30 (w/w)% in terms of a dried matter. Commonly speaking, the daily dosage is, for example, about 1-5,000, preferably about 100-3,000 mg/adult of the extract of matico (dried product).
AIM: In a primary care population at high risk of type 2 diabetes, 24-month weight change trajectories were used to investigate the impact of weight cycling on fat mass (FM) and fat-free mass (FFM).
MATERIALS AND METHODS: Cohort data from the Walking Away from Type 2 Diabetes trial was used, which recruited adults at-risk of type 2 diabetes from primary care in 2009/10. Annual weight change trajectories based on weight loss/gain of ≥5% were assessed over two 24-month periods. Body composition was measured by bioelectrical impedance analysis. Repeated measures were analysed using generalized estimating equations with participants contributing up to two 24-month observation periods.
RESULTS: In total, 622 participants were included (average age = 63.6 years, body mass index = 32.0 kg/m2 , 35.4% women), contributing 1163 observations. Most observations (69.2%) were from those that maintained their body weight, with no change to FM or FFM. A minority (4.6% of observations) lost over 5% of body weight between baseline and 12 months, which was then regained between 12 and 24 months. These individuals regained FM to baseline levels, but lost 1.50 (0.66, 2.35) kg FFM, adjusted for confounders. In contrast, those that gained weight between baseline and 12 months but lost weight between 12 and 24 months (5.5% of observations) had a net gain in FM of 1.70 (0.27, 3.12) kg with no change to FFM.
CONCLUSION: Weight cycling may be associated with a progressive loss in FFM and/or gain in FM in those with overweight and obesity at-risk of type 2 diabetes.