anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: We examined the geographic distribution and sociodemographic and economic characteristics of chronic disease prevalence in the US. Understanding disease prevalence and its impact on communities is crucial for effective public health interventions.
METHODS: Data came from the American Community Survey, the American Hospital Association Survey, and the Centers for Disease Control and Prevention's PLACES. We used quartile thresholds for 10 chronic diseases to assess chronic disease prevalence by Zip Code Tabulation Areas (ZCTAs). ZCTAs were scored from 0 to 20 based on their chronic disease prevalence quartile. Three prevalence categories were established: least prevalent (score ≤6), moderately prevalent (score 7-13), and highest prevalence (score ≥14). Community characteristics were compared across categories and spatial analyses to identify clusters of ZCTAs with high disease prevalence.
RESULTS: Our study showed a high prevalence of chronic disease in the southeastern region of the US. Populations in ZCTAs with the highest prevalence showed significantly greater socioeconomic disadvantages (ie, lower household income, lower home value, lower educational attainment, and higher uninsured rates) and barriers to health care access (lower percentage of car ownership and longer travel distances to hospital-based intensive care units, emergency departments, federally qualified health centers, and pharmacies) compared with ZCTAs with the lowest prevalence.
CONCLUSION: Socioeconomic disparities and health care access should be addressed in communities with high chronic disease prevalence. Carefully directed resource allocation and interventions are necessary to reduce the effects of chronic disease on these communities. Policy makers and clinicians should prioritize efforts to reduce chronic disease prevalence and improve the overall health and well-being of affected communities throughout the US.
Control 3: Handwashing with bar soap and contaminated water for 60 seconds. Water which is contaminated with non-pathogenic E.coli. at 2,000 cfu/100ml will be stored in a bucket which has a tap at the base. The control group volunteers will wash their hands with the contaminated water and bar soap for 60 seconds. They will follow the "WHO guidelines for handwashing when hands are visibly soiled" (a diagram of the steps will be given to them). After handwashing, hands will be allowed to dry for 3 minutes.
The present invention relates to guidance in examination or interventional procedures. To facilitate information provision in a medical environment such as an operating room or a catheter room, an augmented reality display device (10) for medical equipment is provided, comprising a data input unit (12), a processing unit (20) and a display unit (22). The data input unit is configured to receive display operating parameters (14) of at least one medical instrument. The data input unit is further configured to receive relative positioning information (16) of at least one medical instrument with respect to the display unit and viewing direction information (18) of the user. The processing unit is configured to detect whether at least one of the medical instruments is in a field of view of the user based on the relative positioning information and the viewing direction information. The processing unit is further configured to generate display data based on the detected operating parameter of the medical instrument. The display unit is configured to: projecting information (24) relating to the operating parameter of the medical instrument visible to a user based on the display data if the medical instrument is within a field of view of the user. The display unit is configured to display the information as a visual representation superimposed to reality.
Handwriting deficits, or dysgraphia, are present in several neurodevelopmental disorders. To investigate whether dysgraphia differs according to the associated disorder, we performed a detailed analysis of handwriting in a group of French children with developmental coordination disorders (DCD), reading disorder (RD), or comorbid RD and DCD. Handwriting deficits were investigated at the product (quality of the trace) and the process (movement that generates the trace) levels. Nineteen children with singular RD (among which eight with dysgraphia), 13 children with singular DCD (among which seven with dysgraphia), 16 children with comorbid RD+DCD (among which 11 with dysgraphia), and 20 typically developing children, age 7 to 12, performed the BHK (Brave Handwriting Kinder) test, a standardized assessment of handwriting, on a graphic tablet. Developmental coordination disorders primarily affected handwriting quality, while RD affected slowness and, to a lesser extent, quality. Children with RD, solely or comorbid with DCD, wasted time by lifting and stopping the pen when writing. The comorbidity added to but did not worsen, handwriting difficulties. These results reflect distinct motor impairments and/or strategies in children with DCD or RD. We identified subtypes of dysgraphia and advocated for a fine-grained analysis of the writing process and the assessment of motor and reading skills when studying dysgraphia.
Patients receive selinexor PO twice weekly (e.g. Monday/Wednesday or Tuesday/Thursday or Wednesday/Friday or Thursday/Saturday or Friday/Sunday) and pembrolizumab IV over 30 minutes on day 1. Cycles repeat every 21 days in the absence of disease progression or unacceptable toxicity.
The invention relates to biotechnology. The protein-polypeptide complex having a tissue-specific reparative activity and a rejuvenating activity on the skin tissue is prepared from the nerve and skin tissues of embryos of ungulate livestock during gestation from the middle of the first trimester to the middle of the last trimester of pregnancy by homogenization in a buffer solution with simultaneous extraction in the presence of non-ionic detergents at a рН of 5.2-8.5. The resultant homogenate is centrifuged and filtered. The proteins are isolated on a chromatography column with an anion exchange medium. The resultant fractions are combined and subjected to sterilizing filtration. The complex comprises negatively charged, weakly acidic, neutral proteins and polypeptides with molecular masses of from 5 to 200 kDa. Furthermore, at least 70% of the total mass of protein has a molecular mass in the range of from 20 to 160 kDa. The pharmacological composition comprises, as active ingredient, a complex with a concentration of 0.05-2.0 mg/ml and a pharmaceutically acceptable diluent.
BACKGROUND: Premature ventricular contractions (PVCs) are common arrhythmias with diverse clinical implications. This retrospective study aimed to evaluate the efficacy of medical treatments using various clinical, imaging, and electrocardiographic parameters in patients with idiopathic PVCs.
METHODS: A total of 1051 patients with idiopathic PVCs were retrospectively analyzed. Patients were categorized into three groups based on treatment response: beta-blocker (BB) responders (479 patients), calcium-channel blocker (CCB) responders (335 patients), and class 1c antiarrhythmic (AA) responders (237 patients). Clinical, imaging, and electrocardiographic data were collected and analyzed to assess the factors influencing treatment response.
RESULTS: Age, left ventricular ejection fraction (LVEF), PVC QRS duration, CI variability, and multiple PVC morphologies were identified as significant factors affecting treatment response. Older age and lower LVEF were associated with better response to BB treatment, whereas CCB responders showed narrower QRS complexes. BB responders also exhibited higher CI variability, possibly linked to automaticity mechanisms. Moreover, the BB responder group had a higher frequency of multiple PVC morphologies.
CONCLUSION: These findings emphasize the importance of tailored treatment approaches based on individual patient characteristics.
This invention is a method for cryogenic treatment of a lesion (20) which comprises the steps of delivering a fluoro-chemical liquid to the lesion (20), placing at least one cryoprobe (26) into the lesion (20), and circulating a cryogenic fluid causing an ice ball (30) to form in a vicinity around the cryoprobe (26), wherein the ice ball (30) obliterates at least a portion of the lesion (20). The fluoro-chemical liquid is utilized to augment the cryosurgical procedure and is perfused or injected into and/or around the lesion site prior and/or during the application of a cryprobe (26) to the site. In one embodiment of the invention, the fluoro-chemical liquid acts as a contrast agent to enhance real time medical imaging of the lesion area and modifies the environment in and around the lesion area. In another embodiment of the invention, the fluoro-chemical liquid augments cryosurgical procedures by controlling the size and shape of ice balls (30) formed during the cryosurgical procedures. In this embodiment, a fluoro-chemical liquid with a properly chosen thermal conductivity and freezing point is utilized. Depending on the thermal properties chosen, the liquid either augments freezing of the target area and/or promotes thermal conduction to freeze larger areas, or limits the freezing of the target area and reduces thermal conduction. In an non-cryoprobe embodiment, the liquid is cooled to a temperature below the freezing point of the biological tissue. The cooled liquid is then infused into or around the cystic lesion to produce ablation.
Fifteen patients with allergic rhinitis aged 18 - 45 years old. The experiment was a crossover design in which each participant was given three types of exercise: running, cycling, and swimming. The participant perform moderate intensity exercise 30 minutes/time. Physiological variables, lung function variables, allergic rhinitis symptoms variables, and cytokines level in nasal secretion variables were analyzed during pre-and post-exercise. The dependent variables between pre-test and post-test were analyzed by a paired t-test. The dependent variables between groups were analyzed by independent t-test. One way repeated measures ANOVA was used to compare the variables among exercise. Differences were considered to be significant at p \< 0.05.
The present invention discloses a radix glehniae stomach benefiting and salivation promoting meat stewing seasoning and a preparation method thereof. The meat stewing seasoning is prepared by mixing traditional Chinese medicine powder, meat powder and chili powder at a weight ratio of 15:4:1. The Chinese medicine powder consists of the following raw materials in parts by weight: radix glehniae 35-45 parts, walnut kernels 21-26 parts, pine nuts 21-26 parts, choerospondias axillaris fruits 15-18 parts, honey 15-18 parts, rubus parvifolius 15-18 parts, cornus officinalis fruits 15-18 parts, herba equiseti hiemalis 8-13 parts, Chinese yams 8-13 parts, licorice 8-13 parts, rhizoma gastrodiae 8-13 parts, and codonopsis pilosula 8-13 parts. The meat powder consists of rabbit meat, chicken meat, duck meat, goose meat and beef. The chili powder is prepared from capsicum frutescens, shuanshuanla (a capsicum frutescens variety), capsicum annuum var. conoides, capsicum annuum var. grossum, and ornamental peppers. The radix glehniae stomach benefiting and salivation promoting meat stewing seasoning has efficacies of benefiting stomach and promoting salivation, tonifying yin an clearing lungs, and warming and invigorating lungs and kidneys in a long-term consumption.
BACKGROUND: Elderly hip fracture was a common orthopedic emergency with high perioperative complication risks. Combined with preoperative acute heart failure, the risk increases further, with pneumonia being a common complication. The aim of this study was to construct and evaluate risk factor prediction models for perioperative pneumonia in these patients and to explore prognostic factors.
METHODS: A retrospective study design was used to collect data on elderly patients with hip fracture combined with preoperative acute heart failure at the Third Hospital of Hebei Medical University from January 2020 to December 2022. The feature variables were screened by logistic regression and nomogram was constructed. The receiver operating characteristics curve (ROC), decision curve analysis (DCA), and calibration curve were employed to assess the predictive power of the model. Correlation heatmaps and shapley additive explanation (SHAP) were employed to assess key variables and their impact. Employing the Kaplan-Meier curve and Cox regression, the patients' prognosis was ultimately evaluated.
RESULTS: 535 elderly patients with hip fracture combined with preoperative acute heart failure were included in this study. Logistic regression analysis was used to identify combined respiratory disease, hemoglobin, albumin, neutrophils, and blood glucose as independent danger factors for perioperative pneumonia (p < 0.05). The nomogram was designed to display the outcomes instinctively, with an AUC of 0.819. The model was internally validated by initiating self-sampling 1000 times. The calibration curve indicated that the model had excellent treaty. The DCA curve showed that the model had good validity and clinical practicability. Correlation heatmaps and SHAP were visualized and analyzed. The K-M curves indicated that the prognosis of the non-pneumonia group was better than that of the pneumonia group (p = 0.014). COX regression analysis found that the major risk factors for all-cause mortality in patients with acute heart failure(AHF) were age, brain natriuretic peptide, platelet count, and combined respiratory failure (p < 0.05).
CONCLUSION: The prediction model, established in this study, was highly accurate and proved a potent instrument for clinical evaluation of the perioperative pneumonia risk of elderly hip fracture patients with preoperative acute heart failure. We hope that this study can reduce the occurrence of perioperative pneumonia in patients and improve the prognosis of patients.
<P>PROBLEM TO BE SOLVED: To provide polynucleotide binding complexes comprising sterols and saponins.  <P>SOLUTION: The invention relates to complexes comprising sterols and saponins. The complexes can bind a genetic determinant, for example a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contact group and/or a targeting ligand and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in further embodiments be encapsulated by an encapsulation agent, for example, a biodegradable microsphere. The invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practiced on the human or animal body.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Non-treatment seeking individuals meeting criteria for alcohol dependence N=160) will be recruited through advertisement and paid for their participation. Alcoholics, after baseline evaluation, will be assigned through urn randomization (using a double dummy placebo controlled design) to one of four experimental groups, naltrexone (50 mg/day) (N=40), ondansetron (0.25 mg twice a day) (N=40), naltrexone and ondansetron (N=40) or placebos (N=40). Subjects will take the study drugs for 8 days (day 1-5 being the natural observation period). After a minimum of 48 hours of abstinence from alcohol day 6-8) they will undergo an alcohol administration (priming dose) and motivated free choice drinking procedure (on day 8). Alcoholic subjects will receive a brief counseling session at the end of the study to enhance their awareness of problem drinking and to motivate them to seek treatment. Referral for treatment will be offered.A subset of subjects from each medication group (N=15) will undergo a functional MRI brain scan with cue stimulation on day 7, on the evening before the alcohol administration paradigm.

A smaller group of social drinker controls (N=16), recruited and paid in a similar fashion, will be randomly assigned to the same medication groups (4 per group). They will be used as procedure controls for the alcohol administration lab study and as a comparison/contrast group for the brain imaging sub-study.
FIELD: medicine.SUBSTANCE: method involves a combination of therapeutic-preventive measures involving drainage of an upper urinary tract by a percutaneous puncture nephrostomy, an antibiotic prevention, a physiotherapeutic exposure and 10 intramuscular injections of Longidase 3,000 International Units once every three days. On the following day after a drain tube is inserted, the course of an external magnetic-laser therapy consisting of 10 procedures starts. On the 7day following the nephrostomic drain tube insertion, the course of a multi-channel electric stimulation (ME) with bipolar pulse currents with trapezoidal envelope frequency 1-150 Hz, pulse train and pause 2 sec. The exposure covers trapezius and broadest muscle of back, rectus and oblique abdominal muscles. The exposure length is 15-20 minutes. The ME is combined with ultraphonophoresis of Longidase 3,000 IU in a projection of the involved ureter at intensity 0.2 Wt/cmin the continuous mode unstably. The therapeutic course makes 10-12 combined daily procedures. On completion of all the physiotherapeutic procedures, the nephrostomic drain tube is clipped. The drain tube is first clipped for 2 hours a day during 3 days, then for 6 hours during 3 days. Then if an amount of residual urine does not exceed 30 ml, the drain tube is clipped for 24 hours during 3 days. If observing no complications, the nephrostoma is removed.EFFECT: method ensures preventing the range of threatening complications by involving all links of mechanism of postoperative ureter stricture formation, including as a result of creating the high hyaluronidase concentration in paraurethral zone and restoring the ureter patency and peristalsis as fast as possible, and improving the urine passage.2 ex
BACKGROUND: Epidemiological studies have revealed a significant association between impaired kidney function and certain mental disorders, particularly bipolar disorder (BIP) and major depressive disorder (MDD). However, the evidence regarding shared genetics and causality is limited due to residual confounding and reverse causation.
METHODS: In this study, we conducted a large-scale genome-wide cross-trait association study to investigate the genetic overlap between 5 kidney function biomarkers (eGFRcrea, eGFRcys, blood urea nitrogen (BUN), serum urate, and UACR) and 2 mental disorders (MDD, BIP). Summary-level data of European ancestry were extracted from UK Biobank, Chronic Kidney Disease Genetics Consortium, and Psychiatric Genomics Consortium.
RESULTS: Using LD score regression, we found moderate but significant genetic correlations between kidney function biomarker traits on BIP and MDD. Cross-trait meta-analysis identified 1 to 19 independent significant loci that were found shared among 10 pairs of 5 kidney function biomarkers traits and 2 mental disorders. Among them, 3 novel genes: SUFU, IBSP, and PTPRJ, were also identified in transcriptome-wide association study analysis (TWAS), most of which were observed in the nervous and digestive systems (FDR < 0.05). Pathway analysis showed the immune system could play a role between kidney function biomarkers and mental disorders. Bidirectional mendelian randomization analysis suggested a potential causal relationship of kidney function biomarkers on BIP and MDD.
CONCLUSIONS: In conclusion, the study demonstrated that both BIP and MDD shared genetic architecture with kidney function biomarkers, providing new insights into their genetic architectures and suggesting that larger GWASs are warranted.
The duration of the exercise intervention is eight (8) weeks. There will be guided endurance and muscle power training two (2) time weekly. The participants will also be provided with one training program per week for use at home. Data on training at home and other items of physical activity is recorded in a diary. Before the intervention is started, an oncologist will examine the participants condition before brisk physical activity is started. Safety is an important consideration and a nurse will examine the patients before each bout of exercise. A nurse will be present during the entire time of the exercise. A physician is always available for consultations by phone.

Before the intervention starts, baseline measurements will be made in the laboratories of physical exercise in the Tyks Hospital and the Turku University of Applied Sciences. At baseline, endurance, muscle power, balance and body composition will be evaluated and recorded. Endurance will be measured with a submaximal treadmill test. Muscle power will be assessed by a dynamic elevation test, hand pressure test, the lower extremities by repeated squatting-standing and by rising to stand on the toes. Balance is measured in the specific sway platform (one leg and both legs standing). The patients will be asked to fill questionnaires on quality of life (QLQ-c30) and fatigue (FACIT-F) before and after the intervention. The patients will fill in their exercise diaries from the very moment their participation has been decided until the end of the intervention. After exercise intervention the patients also fill the feedback-questionnaire.
Thyroid nodules are very common in clinical practice; they are discovered by palpation in 3-7% and by ultrasound (US) in about 50% of the general population. The majority of thyroid nodules are benign and asymptomatic. The main management of benign thyroid nodules is observation and follow-up; however, a minority of them (10-15%) increase in size over time and may induce symptoms or cosmetic issues. Surgical excision has been established as a treatment for symptomatic benign thyroid nodules. thyroidectomy for benign thyroid disease continues to remain controversial, as there are many conflicting data published in the literature regarding the risk of hypothyroidism and recurrent laryngeal nerve injury stratified to indications for surgery, extent of thyroid resection and surgical volume .It carries a 2-10% risk of complications and neck scarring .Thyroid surgery is also costly and may not be appropriate for patients who have a high risk of surgical morbidity.Therefore, image-guided nonsurgical procedures such as ethanol ablation (EA) and thermal ablation have been proposed as alternative and less invasive approaches for the management of benign symptomatic thyroid nodules .These so-called thermoablative methods induce local thermodestruction, leading to nodule shrinkage and improvement of local symptoms. Monopolar radiofrequency ablation (RFA) and EA is widely used as a nonsurgical treatment usually for cystic (i.e., pure cyst) or predominantly cystic benign thyroid nodules (i.e., cystic portion \> 50%). There is another method called US-guided percutaneous laser ablation (PLA) is a safe and effective therapeutic option as an alternative to surgery for benign symptomatic nodules