anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: We aimed to improve the prognosis, treatment, and management of Staphylococcus aureus bacteremia (SAB) by evaluating the association between adherence to quality indicators (QIs) and clinical outcomes in patients with their clinical outcomes.
METHODS: We retrospectively collected clinical and microbiological data on hospitalized patients with SAB from 14 hospitals (three with >  600, two with 401-600, five with 201-400, and four with ≤ 200 beds) in Japan from January to December 2022. The SAB management quality was evaluated using the SAB-QI score (ranging from 0 to 13 points), which consists of 13 QIs (grouped into five categories) based on previous literature.
RESULTS: Of the 4,448 positive blood culture episodes, 289 patients with SAB (6.5%) were enrolled. The SAB-QI scores ranged from 3 to 13, with a median score of 9 points. The SAB-QI score was highest in middle-sized hospitals with 401-600 beds. Adherence to each of the four QI categories (blood culture, echocardiography, source control, and antibiotic treatment) was significantly higher in survived cases than in fatal cases. Kaplan-Meier curves with log-rank tests demonstrated that higher adherence to SAB-QIs indicated a better prognosis. Logistic regression analysis revealed that age, methicillin resistance, multiple comorbidities (≥ 2), and low SAB-QI score were significantly associated with 30-day mortality in patients with SAB.
CONCLUSIONS: Our study highlights that greater adherence to the SAB-QIs correlates with improved patient outcomes. Management of patients with SAB should follow these recommended indicators to maintain the quality of care, especially for patients with poor prognosticators.
PURPOSE:A method for spraying and inhaling an aerosol containing lmenthol, Dl-camphor, methyl salicylate and glycol salicylate from the nasal cavity or oral cavity to revive cerebral cells. CONSTITUTION:An aerosol containing l-menthol, Dl-camphor, methyl salicylate and glycol salicylate is sprayed and inhaled from the nasal cavity or oral cavity to revive cerebral cells. The above-mentioned aerosol is considered useful for preventing diseases by producing effects on various symptoms as follows; The aerosol is capable of activating the heart muscle and pericardiac muscle to revive the function and movement of the heart. Inhaled toxic substances are neutralized to eliminate toxicity, and lungs, etc. are simultaneously activated to prevent humans from catching cold. The consciousness center of interbrain or brain stem or mesencephalon is activated to make consciousness clear. The heart pericardiac external muscle is activated to revive the heart rate by thorough transmission of space signals, etc.
Laparoscopic cholecystectomy was the standard surgical method for acute cholecystitis unless difficulty in resection due to acute inflammation, no improvement after supportive therapy, or early inability to tolerate cholecystectomy. In this setting, gallbladder drainage was needed. Percutaneous transhepatic gallbladder drainage (PTGBD)was used as a first-line mitigation method, whose restrictions are contraindications and strong pain caused by puncture. Endoscopic technique based on endoscopic retrograde cholangiopancreatography (ERCP) had been made another alternative management for drainage. Endoscopic drainage expanded the indications for drainage without reducing the technical success rate and clinical remission rate, especially less uncomfortable, which greatly improved the quality of life for patients. Unfortunately, because of the difficult procedures and long learning curve, endoscopic gallbladder drainage can only be performed in some large endoscopic centers. Despite a few prospective comparison of PTGBD and endoscopic ultrasound EUS drainage studies so far, there is no prospective study comparing endoscopic naso-gallbladder drainage （ENGBD） and PTGBD, especially in its impacts while cholecystectomy. This study aim to observe clinical effects of ENGBD and PTGBD during the all stage of peri-cholecystectomy.
Type 2 Diabetes mellitus (T2DM) is a metabolic disorder characterized by chronic hyperglycemia, resulting from deficits in insulin secretion, insulin action, or both. Whilst the role of insulin in the peripheral nervous system has been ascertained in countless studies, its role in the central nervous system (CNS) is emerging only recently. Brain insulin has been lately associated with brain disorders like Alzheimer's disease, obsessive compulsive disorder, and attention deficit hyperactivity disorder. Thus, understanding the role of insulin as a common risk factor for mental and somatic comorbidities may disclose novel preventative and therapeutic approaches. We evaluated general metabolism (glucose tolerance, insulin sensitivity, energy expenditure, lipid metabolism, and polydipsia) and cognitive capabilities (attention, cognitive flexibility, and memory), in adolescent, young adult, and adult male and female TALLYHO/JngJ mice (TH, previously reported to constitute a valid experimental model of T2DM due to impaired insulin signaling). Adult TH mice have also been studied for alterations in gut microbiota diversity and composition. While TH mice exhibited profound deficits in cognitive flexibility and altered glucose metabolism, we observed that these alterations emerged either much earlier (males) or independent of (females) a comprehensive constellation of symptoms, isomorphic to an overt T2DM-like phenotype (insulin resistance, polydipsia, higher energy expenditure, and altered lipid metabolism). We also observed significant sex-dependent alterations in gut microbiota alpha diversity and taxonomy in adult TH mice. Deficits in insulin signaling may represent a common risk factor for both T2DM and CNS-related deficits, which may stem from (partly) independent mechanisms.
HIBC Exercise Protocol- circuit repetition and order is as follows: modified squats (10 repetitions), modified rows (5 repetitions), crunches (10), and modified push-ups (5). The exercise sessions will involve repeating a series of repetitions of each movement in sequence, and completing as many sequences as possible in good form in the time allotted for the exercise (initially, 5 minutes). Three sessions per week will be completed at home. After three weeks of training, participants will be asked to add a fourth session each week. Initially, the HIBC sessions will be five minutes long, and the duration of the sessions will increase by one minute each week as tolerated beginning in week four, peaking at 10-minutes per session (warm up not included in this timing) as early as the eighth week of training. Session duration will be capped at 10-minutes.
### Teratogenic effects: Pregnancy Category C:

Animal studies have not been conducted with FML-S® ophthalmic suspension. Fluorometholone has been shown to be embryocidal and teratogenic in rabbits when administered at low multiples of the human dose. Fluorometholone was applied ocularly to rabbits daily on days 6-18 of gestation and dose-related fetal loss and fetal abnormalities including cleft palate, deformed rib cage, anomalous limbs and neural abnormalities such as encephalocele, craniorachischisis, and spina bifida were observed. Kernicterus may be precipitated in infants by sulfonamides being given systemically during the third trimester of pregnancy. There are no adequate and well-controlled studies of FML-S® ophthalmic suspension in pregnant women, and it is not known whether FML-S® ophthalmic suspension can cause fetal harm when administered to a pregnant woman. FML-S® ophthalmic suspension should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
PURPOSE: Keratoconus presents certain peculiarities in pediatric patients when compared with adults. The greatest challenge in children is that the disease is more severe and faster in progression. In this retrospective study, we aimed to compare the accelerated and Dresden protocols for corneal crosslinking in patients aged <18 years who were followed-up for at least 12 months. Methods: A total of 36 eyes from 27 patients were included in the study. The best corrected and uncorrected visual acuity, maximal keratometry, corneal thickness, foveal thickness, and endothelial microscopy findings were evaluated at baseline and during the postoperative period at one, three, and six months. Thereafter, the patients were evaluated at one, three, six and twelve months postoperative. Corneal crosslinking was performed in all patients via the Dresden protocol (n=21 eyes) or the accelerated protocol (n=15 eyes). Data between the two groups were compared and XY statistical analysis was used.
RESULTS: Both protocols were effective in halting keratoconus progression. No patient had progression at the 12-month follow-up. A significant reduction in Kmax and improvement in the corrected distance visual acuity were observed only in the Dresden protocol group. Although the Dresden protocol was superior to the accelerated protocol in reducing Kmax (p=0.002), there was no significant difference in corrected distance visual acuity between the two groups.
CONCLUSION: The accelerated protocol is as efficient as the Dresden protocol in stabilizing keratoconus progression. Although the Dresden protocol was superior to the accelerated protocol in reducing the Kmax, it did not produce better clinical results. Thus, the accelerated protocol is an efficient option. Furthermore, considering the advantages of reduced surgical time, the accelerated protocol is effective in halting keratoconus progression in the pediatric age group.
This article presents a case of a 31-year-old male patient who presented to the outpatient department of the Krasnov Research Institute of Eye Diseases with complaints of diplopia and increased intraocular pressure (IOP) up to 30 mm Hg. The patient had been using minoxidil topically for androgenic alopecia for 8 years. On examination, mild swelling of the bulbar conjunctiva in the upper fornix was revealed; optical coherence tomography showed thinning of the ganglion cell layer, most likely due to moderate myopia. The patient responded well to discontinuation of minoxidil and topical therapy with prostaglandin analogues. After 4 months, an attempt was made to replace topical hypotensive therapy with carbonic anhydrase inhibitors, but the previous hypotensive regimen had to be resumed due to an increase in IOP. During 10 months of observation, no signs of progression were detected according to optical coherence tomography and static perimetry.
There are hundreds of genes typically overexpressed in breast cancer cells and it's often assumed that their overexpression contributes to cancer progression. However, the precise proportion of these overexpressed genes contributing to tumorigenicity remains unclear. To address this gap, we undertook a comprehensive screening of a diverse set of seventy-two genes overexpressed in breast cancer. This systematic screening evaluated their potential for inducing malignant transformation and, concurrently, assessed their impact on breast cancer cell proliferation and viability. Select genes including ALDH3B1, CEACAM5, IL8, PYGO2, and WWTR1, exhibited pronounced activity in promoting tumor formation and establishing gene dependencies critical for tumorigenicity. Subsequent investigations revealed that CEACAM5 overexpression triggered the activation of signaling pathways involving β-catenin, Cdk4, and mTOR. Additionally, it conferred a growth advantage independent of exogenous insulin in defined medium and facilitated spheroid expansion by inducing multiple layers of epithelial cells while preserving a hollow lumen. Furthermore, the silencing of CEACAM5 expression synergized with tamoxifen-induced growth inhibition in breast cancer cells. These findings underscore the potential of screening overexpressed genes for both oncogenic drivers and tumor dependencies to expand the repertoire of therapeutic targets for breast cancer treatment.
Most cases of hepatocellular carcinoma (HCC) arise in patients with advanced liver disease, usually cirrhosis. Most patients with clinically evident HCC are not candidates for treatment with curative intent because of large tumor size, invasion of hepatic or portal veins, or metastatic disease. For this reason, screening for HCC at an asymptomatic and potentially curable stage in patients with advanced liver disease has been recommended by some authorities. Screening with various methods, of which ultrasound (US) and alpha-fetoprotein (AFP) have been the most extensively studied, has become accepted practice. Recently the technique of imaging the liver with or during both the hepatic arterial and portal venous phases of intravenous contrast ("liver-shuttle") has shown increased sensitivity in detecting HCCs compared to US.

The hypothesis of this study is that CT using a "liver-shuttle" protocol once a year is more sensitive and specific than US twice a year, both in combination with AFP for identification of potentially curable HCC in patients with cirrhosis. Patients will be randomized to "routine," accepted screening with hepatic US and AFP testing every 6 months or AFP testing every 6 months wtih triphasic CT every 12 months.
PURPOSE:To achieve the significant mitigation of the post-injection pain of 3- benzoylhydratoropic acid injected as an anti-inflammatory analgesic agent, by using a post-injection pain mitigating agent obtained by adding a local anesthetic such as procaine hydrochloride to benzyl alcohol used as a solvent. CONSTITUTION:The pain after the injection of 3-benzoylhydratropic acid of formula can be mitigated by adding a local anesthetic (e.g. procaine hydrochloride, mepivacaine hydrochloride, lidocaine, etc.) to benzyl alcohol used as a solvent. As an alternative method, an ampule containing an aqueous solution of benzyl alcohol added with a local anesthetic or an ampule containing the compound of formula and procaine hydrochloride as a solvent of the compound, can be used as a post-injection pain mitigating agent. The paint after the injection of the compound of formula can be mitigated by the method of the present invention or by the use of the agent.
Knowledge of the molecular pathways of pediatric high-grade gliomas is increasing. Gliomas with mismatch repair deficiency do not currently comprise a distinct group, but data on this topic have been accumulating in recent publications. Immunohistochemistry can effectively determine mismatch repair status, indirectly suggesting the microsatellite instability of the tumor. This study aimed to determine the number of mismatch repair-deficient pediatric high-grade gliomas in a tertiary institution and assess the relationship between the survival and mismatch repair status of the patients. It also aimed to assess the potential for further clinical studies including immunotherapy. Of 24 patients with high-grade gliomas, 3 deceased patients were mismatch repair-deficient. Mismatch repair deficiency was significantly associated with shorter survival ( P =0.004). Immunotherapy trials need to progress, and patients with mismatch repair-deficient pediatric high-grade gliomas are the most suitable candidates for such studies.
The invention relates to a super positive charge polypeptide and application thereof. The super charge polypeptide is constructed by full artificial design, is composed of 5 amino acids of glycine, alanine, serine, threonine, proline and 6-7 types of amino acids of lysine and/or arginine, and can be fused with bioactive protein or polypeptide for expression. The superpositive polypeptides may be used as intracellular delivery vehicles for proteins and polypeptides. The method for taking the super positive charge polypeptide as the intracellular delivery carrier of the protein or the polypeptide can efficiently deliver the proteins and the polypeptides with different molecular weights and isoelectric points from outside cells into the cells, and retain the biological functions and the activities of the delivered proteins or polypeptides. Meanwhile, the super charge polypeptide has good biological safety. The invention displays an intracellular delivery system of the protein or polypeptide with high efficiency and safety, and has good research and development application prospects in the field of biological medicines.
<P>PROBLEM TO BE SOLVED: To provide a neurite outgrowth-promoting polypeptide based on a neuroglycan C and the use of the same.  <P>SOLUTION: This polypeptide holds at least the following amino acid sequence and consists of 12-400 amino acid residues. Asp Asp Leu Xaa Glu Glu Glu Glu Glu Glu Glu Asp (wherein, Xaa is Glu or Asp residue). The polypeptide holds at least the following amino acid sequence and consists of 39-400 amino acid residues. Cys Asp Leu Phe Pro Ser Tyr Cys His Asn Gly Gly Gln Cys Tyr Leu Val Glu Asn Ile Gly Ala Phe Cys Arg Cys Asn Thr Gln Asp Tyr Ile Trp His Lys Gly Met Arg Cys. The fused polypeptides obtained by bonding another polypeptide to these polypeptides, the nucleic acids encoding such polypeptides and a neurite outgrowth-promoting agent using such polypeptides as active ingredients are also provided.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Neuroendocrine tumors are uncommon in the gastrointestinal system but can develop in the majority of the body's epithelial organs. Our goal was to examine the presence and clinical application of serum dopamine (DA), serotonin (ST), norepinephrine (NE), and epinephrine (EPI), in addition to determining the significance of the Prognostic Nutritional Index (PNI), Glasgow Prognostic Score (GPS), and systemic inflammatory response (SIR) markers as a prognostic factor for patients with colorectal neuroendocrine tumors (CR-NETs), in various tumor-node-metastasis (TNM) stages. We also wanted to identify the possible connection between them. This study included 25 consecutive patients who were diagnosed with CR-NETs and a control group consisting of 60 patients with newly diagnosed colorectal cancer (CRC). We used the Enzyme-Linked Immunosorbent Assay (ELISA) technique. This study revealed that CR-NET patients showed significantly higher serum levels of DA compared to CRC patients. We showed that serum DA was present in the early stages of CR-NETs, with increasing levels as we advanced through the TNM stages. Moreover, we found a close relationship between the levels of DA and the inflammation and nutritional status of the CR-NET patients in this study. CR-NET patients from the PNI < 47.00 subgroup had a higher level of DA than those from the PNI ≥ 47.00 subgroup. Pearson's correlation analysis revealed correlations between DA, PNI, and the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR). Both hematological indices were negatively correlated with albumin (ALB). Our investigation's findings relating to the PNI, GPS, SIR, and DA indicate that these tools can be markers of nutritional and systemic inflammatory status, are simple to use, and are repeatable. Further research on this topic could provide valuable insights into which biomarkers to incorporate into clinical practice for the management of CR-NET patients.
Participants received enzalutamide matching placebo orally, once daily (QD) during double blind treatment period until disease progression, unacceptable toxicity, or any other discontinuation criterion was met. Median treatment duration was 64 days.
The invention relates to a method and a device for improving parameter accuracy of a cell analyzer. The device consists of three parts: cell analyzer, osmometer, and correction formula converter. The osmometer is connected to a cell analyzer and a calibration equation converter to form a unit. The device comprises a cell analyzer and an osmometer, can simultaneously determine parameters such as MCV and the like and plasma osmotic pressure parameters and transmits the parameters to a correction formula converter. The osmometer can detect whether the plasma osmolality is abnormal, and when the plasma osmolality is abnormal (too high or too low), the cell analyzer MCV can be falsely increased or decreased. The correction formula converter contains a mathematical formula of the relation between the MCV and the plasma osmotic pressure, and can convert the MCV with deviation into the MCV without deviation through the correction of the converter, and then output the corrected MCV, thereby improving the accuracy of the MCV, improving the accuracy of parameters closely related to the MCV or the plasma osmotic pressure, such as MCHC, HCT, MPV, PCT and the like, and providing accurate parameters of a cell analyzer for a clinician.
Superficial venous thrombosis is a common complication in patients with varicose veins of low extremities. The most dangerous consequence of such thrombosis is its propagation to deep veins and subsequent pulmonary embolism. Recommended mode of treatment for superficial vein thrombosis is a prolonged usage of anticoagulants (preferably fondaparinux sodium for least 45 days as the best-studied approach). However, it may be not suitable for some patients, for example with a high risk of bleeding. Another possible mode of treatment is endovenous laser ablation of the saphenous vein very close to the saphenofemoral junction. This a minimally invasive procedure that may be performed ambulatory is able to decrease the risk of deep veins thrombosis and possibly allow to shorten or even eliminate the necessity of anticoagulant use. Such a suggestion was not appropriately studied in randomized clinical trials.

The aim of this prospective single-centre randomized open-label study is to compare three modes of treatment for thrombosis of varicose great saphena vein - standard medical with fondaparinux sodium, endovenous laser ablation close to the saphenofemoral junction with shortening the course of anticoagulation and endovenous laser ablation close to the saphenofemoral junction without the use of anticoagulants.
PURPOSE: A hair setting composition containing useful polymers and oil is provided to express natural hair style without flaking. CONSTITUTION: A hair setting composition contains useful polymers and oil. The HLB value of the useful polymer is 0.01-6. A copolymer contains 1-80 parts by weight of (meth)acrylate-based monomer units(A and B), 1-20 parts by weight of monomer units(C) containing a carboxyl group, and 0.1-5 parts by weight of soap monomers(D) as active ingredients, which are denoted by chemical formula 1. The copolymer is a random, alternating, block, or graft polymer. [Reference numerals] (AA) Soap monomer
A method for providing a collision model includes detecting an item of patient information that has an item of information on a spatial placement of an entry point of a medical object into an object undergoing examination. The item of patient information is registered with a movable medical device. The method also includes detecting an item of object information that has an item of information on a geometry and spatial position of a manipulator for moving the medical object. The manipulator includes a motion device and/or a member of technical medical personnel. A relative placement of the manipulator in relation to the object undergoing examination is determined based on the item of patient information and the item of object information. The collision model is provided for the purpose of moving the medical device based on the relative placement and the item of object information.