anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Bronchopleural fistula (BPF) is a potentially fatal complication and remains a surgical challenge. Concomitant problems, such as pulmonary infection and respiratory failure, are typically the main contributors to mortality from BPF because of improper contact between the bronchial and pleural cavity. We present the case of a 75-year-old male patient with a history of right upper lobe lung cancer resection who developed complex BPFs. Following appropriate antibiotic therapy and chest tube drainage, we treated the fistulas using endobronchial valve EBV placement and local argon gas spray stimulation. Bronchoscopic treatment is the preferred method for patients who cannot tolerate a second surgery because it can help to maximize their quality of life. Our treatment method may be a useful reference for treating complex BPF.
Techniques to enhance use dependent plasticity have been examined in stroke rehabilitation research. The purpose of these techniques is to prime the cortex prior to training. The priming techniques previously described in the literature include medication (i.e. amphetamines), transcranial electric or magnetic stimulation, and manipulation of somatosensory input. Here, the investigators examine a priming technique which is non-invasive and free of side effects. The technique described in this study uses bilateral, symmetrical, rhythmic movement "bilateral priming" and its purpose is to ready the motor cortex for functional limb training. A "rocker" is used so that the less affected limb can drive the affected one in symmetrical wrist flexion and extension. In this project, the investigators intend to compare bilateral upper limb priming with task specfiic training to a health care education website program followed by the same task specific training as the experimental group.This active comparator (health care education) will receive stroke related health education via a website from the American Heart Association. Transcranial Magnetic Stimulation willl include measurement of transcallosal inhibition persistence from the affected hemisphere to the less affected hemisphere and vice versa ( less affected to affected). The investigators expect the bilateral priming group to have greater changes in transcranial magnetic stimulation measures and greater improvements in behavioral measures at all time points.
BACKGROUND: Cardiac myxomas are the most common type of primary cardiac tumors in adults, but they can have variable features that make them difficult to diagnose. We report two cases of atrial myxoma with calcification or ossification, which are rare pathological subgroups of myxoma.
CASE PRESENTATION: A 47-year-old woman and a 35-year-old man presented to our hospital with different symptoms. Both patients had a history of chronic diseases. Transthoracic and transesophageal echocardiography revealed a mass in the left or right atrium, respectively, with strong echogenicity and echogenic shadows. The masses were suspected to be malignant tumors with calcification or ossification. Contrast transthoracic echocardiography(cTEE) showed low blood supply within the lesions. The patients underwent surgical resection of the atrial mass, and the pathology confirmed myxoma with partial ossification or massive calcification.
CONCLUSION: We report two rare cases of atrial myxoma with calcification or ossification and analyze their ultrasonographic features. Transthoracic echocardiography and cTEE can provide valuable information for the diagnosis and management of such mass. However, distinguishing calcification and ossification in myxoma from calcification in malignant tumors is challenging. More studies are needed to understand the pathogenesis and imaging characteristics of these myxoma variants.
As part of the standard of care, flight paramedics will insert an esophageal or rectal temperature probe in patients meeting including criteria to enable continuous temperature monitoring. Paramedics will measure core temperature on at least two occasions, the first measurements made at least 5 minutes after insertion of the temperature probe, and also prior to departure from the sending facility.
The present invention provides an inhalation-type pharmaceutical composition for alzheimer's disease comprising a first gas and a vaporized pharmaceutical liquid. The first gas comprises hydrogen. The hydrogen has a gas volume concentration between 2% and 96% in the inhalation-type pharmaceutical composition. The vaporized pharmaceutical liquid comprises at least one selected from the group consisting of rivastigmine hydrogen tartrate, donepezil hydrochloride, galantamine hydrobromide, and memantine hydrochloride. The inhalation-type pharmaceutical composition of the present invention can remove reactive oxygen, and the vaporized pharmaceutical liquid can improve absorbability in the present invention. At the same time, because the use of the small amount of the vaporized pharmaceutical liquid indirectly reduce the side effects of human.
The Continuous Enrollment is a Facebook-delivered weight loss intervention. Participants in this arm were randomized to this Facebook group and started the intervention together. For this group, the study team continued to enroll participants through week 8.
A composition for preventing and treating diseases mediated by MAO (monoamine oxidase), which contains an Angelica keiskei Koidzumi or compound extracted therefrom. A composition for preventing and treating diseases mediated by MAO comprises Angelica keiskei Koidzumi as an active ingredient. The composition for preventing and treating diseases mediated by MAO further comprises a compound of the chemical formula 3. In the chemical formula 3, R1 is hydroxyl group or C1-C4 alkoxy group. The compound of the chemical formula 3 is a hydroxydericin. The disease mediated by the over-activation of MOA is depression, migraine, parkinsonism, alzheimer disease, gliosis, panic disorder, attention deficit disorder, or hypersomnia. A medicinal and pharmaceutical product comprises the composition and pharmaceutically allowable carrier or additive. The medicinal and pharmaceutical product is used in a form of powder, granule, tablet, capsule, suspension, emulsion, syrup, solution, aerosol, or suppository.
Lynch syndrome (LS) is the most prevalent heritable form of colorectal cancer. Its early onset and high lifetime risk for colorectal cancer emphasize the necessity for effective chemoprevention. NFE2L2 (NRF2) is often considered a potential druggable target, and many chemopreventive compounds induce NRF2. However, although NRF2 counteracts oxidative stress, it is also overexpressed in colorectal cancer and may promote tumorigenesis. In this study, we evaluated the role of NRF2 in the prevention of LS-associated neoplasia. We found increased levels of NRF2 in intestinal epithelia of mice with intestinal epithelium-specific Msh2 deletion (MSH2ΔIEC) compared with C57BL/6 (wild-type) mice, as well as an increase in downstream NRF2 targets NAD(P)H dehydrogenase (quinone 1) and glutamate-cysteine ligase catalytic subunit. Likewise, NRF2 levels were increased in human MSH2-deficient LS tumors compared with healthy human controls. In silico analysis of a publicly accessible RNA sequencing LS dataset also found an increase in downstream NRF2 targets. Upon crossing MSH2ΔIEC with Nrf2null (MSH2ΔIECNrf2null) mice, we unexpectedly found reduced tumorigenesis in MSH2ΔIECNrf2null mice compared with MSH2ΔIEC mice after 40 weeks, which occurred despite an increase in oxidative damage in MSH2ΔIECNrf2null mice. The loss of NRF2 impaired proliferation as seen by Ki67 intestinal staining and in organoid cultures. This was accompanied by diminished WNT/β-catenin signaling, but apoptosis was unaffected. Microbial α-diversity increased over time with the loss of NRF2 based upon 16S rRNA gene amplicon sequencing of murine fecal samples. Altogether, we show that NRF2 protein levels are increased in MSH2 deficiency and associated neoplasia, but the loss of NRF2 attenuates tumorigenesis. Activation of NRF2 may not be a feasible strategy for chemoprevention in LS. Prevention Relevance: Patients with LS have an early onset and high lifetime risk for colorectal cancer. In this study, we show that NRF2 protein levels are increased in MSH2 deficiency and associated neoplasia, but the loss of NRF2 attenuates tumorigenesis. This suggests that NRF2 may not be a tumor suppressor in this specific context.
The invention relates to a beta-hydroxy-alpha-amino acid derivative represented by formula (I), and a chemical synthesis method thereof. The method comprises the following steps: carrying out a one-step reaction on raw materials comprising alpha-aryldiazoester, arylamine and arylaldehyde at room temperature with monovalent metal rhodium as a catalyst and an organic solvent as a solvent, and carrying out column chromatography purification to obtain a product. The preparation method has the advantages of high step economy, strong atom economy, high diastereoselectivity, high yield, mild reaction conditions, and simple and safe operation. The beta-hydroxy-alpha-amino acid novel derivative is an important compound for preparing various bioactive natural products and medicines. The invention also discloses an application of the beta-hydroxy-alpha-amino acid derivative in the inhibition of activity of protein tyrosine phosphatase. The derivative has a wide application prospect in the field of pharmaceutical and chemical engineering.
Music Glove is a glove with sensors attached to the tips of all 5 fingers. The glove is connected to a software musical program like guitar hero. Participants will follow the rhythm or musical notes of the songs and move their fingers accordingly. Participants are reinforced with biofeedback that includes visual and auditory cues when the correct sequences are achieved.
The application provides a polypeptide, which is characterized in that the amino acid sequence of the polypeptide comprises a sequence shown as SEQ ID No.1, SEQ ID No.2 or SEQ ID No. 3. The application also relates to application of the polypeptide in preparing anticoagulant medicaments. The application also relates to compositions comprising said polypeptides. The application also relates to application of the polypeptide with the amino acid sequence of SEQ ID NO.4 in preparing anticoagulant medicaments and a composition comprising the polypeptide with the amino acid sequence of SEQ ID NO. 4. The polypeptide provided by the invention has good anticoagulant activity and good application prospect.
NEW MATERIAL:The alkylenediamine derivative of formula I [R<1> is 3-8C straight or branched aliphatic hydrocarbon group, 5-8C cycloaliphatic hydrocarbon group, aryl, etc.; R<2> is 3-11C straight or branched aliphatic hydrocarbon group, 3-11C aliphatic hydrocarbon group containing ester bond, 3-11C aliphatic hydrocarbon group containing ether bond, etc.; k is 1-4; p is 2-6; q is 4-7] or its salt. EXAMPLE:1-[3-[N,N-bis(3-methylbutyl)amino]propyl]piperidine. USE:Useful as a glutamic acid blocker. It is used as a remedy for neuropathy caused by imbalance of nervous system or abnormal sthema of muscular pulse. It is useful also as an agricultural chemical since the compound suppresses the activity of insects. PREPARATION:The compound of formula I can be produced e.g. by reacting the carboxylic acid of formula II with the alkylenediamine compound of formula III and reducing the reaction product.
Subjects will attend to exercise classes (community-based) 2 times per week during 3 months. The exercise classes last approximately 60 minutes. The group exercise classes consists of a variety of exercises designed to increase general muscular strength, low impact aerobic exercise, range of movement, and activity for daily living.
In the past few decades there has been predictions regarding the level of edentulism, and the need for prosthetic rehabilitation of the population. Although studies estimate a decline in the percentage of edentulism, and a decreased need for removable prostheses, this is predicted to be offset by a projected 79% increase in the population that is 55 years or older, the number of individuals with existing prostheses needing new prostheses and maintenance, and the professional and public health responsibility to serve this population regardless to the level of edentulism. In spite of these demographic predictions, the need for prosthodontics services, both fixed dental prostheses and removable dental prostheses will continue to an oral health concern, in part due to the an aging population that retains more of their teeth resulting in partial edentulism.

Prosthetic rehabilitation should not only replace missing teeth, but it should restore oral function and have a positive impact on Oral-Health-Related Quality of Life (OHRQoL) of our patients. As the population continues to age worldwide, and the U.S. specifically, it will become increasingly important to improve the OHRQoL for the segment of our population possessing removable prostheses with high stability, and highly retentive prosthetic services. Traditionally, both complete and partial removable dentures lack retention and stability, and one recommendation to improve the function has been to utilize dental implants to retain and stabilize the prosthesis. Although, several investigations have evaluated the OHRQoL patients wearing removable the preponderate emphasis of these studies has been on complete denture patients. In addition, OHRQoL studies are generated by patient self-reports, and limited evaluation of actual oral function has been compared to the patient self-reported function. This study will use the OHIP to evaluate the OHRQoL of patients with distal extension partial dentures, as well as, actually measure the patients chewing ability.

This prospective cohort study is designed to gather preliminary data on the improvement of patient satisfaction and oral function for individuals wearing distal extension partial dentures that are supported by smaller length dental implants. Thirty healthy male and female participants aged 18 to 65 will be treated at the University of Minnesota Dental School, in the Clinical Research Center. A lower partial denture will be fabricated using routine prosthodontic techniques. The participants will receive a 7 mm X 3.75 mm or a 8.5 mm X 4.1 mm tapered implant, A Locator Abutment will be used to connect the denture to the implant to improve the retention and stability of the partial denture. The chewing ability and chewing pattern will be evaluated with a jaw-tracking device and the masticatory muscle activity will be evaluated with surface Electromyography (EMG). OHRQoL, chewing function, and patient satisfaction will be measured at the 1, 2, 6, and 12-month recall appointments.
The endoplasmic reticulum (ER) is indispensable for maintaining normal life activities. Dysregulation of the ER function results in the accumulation of harmful proteins and lipids and the disruption of intracellular signaling pathways, leading to cellular dysfunction and eventual death. Protein misfolding within the ER disrupts its delicate balance, resulting in the accumulation of misfolded or unfolded proteins, a condition known as endoplasmic reticulum stress (ERS). Renal fibrosis, characterized by the aberrant proliferation of fibrotic tissue in the renal interstitium, stands as a grave consequence of numerous kidney disorders, precipitating a gradual decline in renal function. Renal fibrosis is a serious complication of many kidney conditions and is characterized by the overgrowth of fibrotic tissue in the glomerular and tubular interstitium, leading to the progressive failure of renal function. Studies have shown that, during the onset and progression of kidney disease, ERS causes various problems in the kidneys, a process that can lead to kidney fibrosis. This article elucidates the underlying intracellular signaling pathways modulated by ERS, delineating its role in triggering diverse forms of cell death. Additionally, it comprehensively explores a spectrum of potential pharmacological agents and molecular interventions aimed at mitigating ERS, thereby charting novel research avenues and therapeutic advancements in the management of renal fibrosis.
This study will include patients with a diagnosis of metabolic syndrome combined with one or more metabolic disorders (e.g., type 2 diabetes mellitus, fatty liver disease, hypertension, etc.) who are determined to be on the verge of undergoing relevant surgical procedures. Patients will be categorised into patients with comorbid hypertension, patients with comorbid diabetes mellitus and patients with comorbid fatty liver disease according to their comorbid metabolic diseases. Basic preoperative information was collected, and blood and stool were collected for hormone testing and metabolomics measurements before surgery. Comparison of metabolic disease remission after surgery was performed to evaluate the efficacy. To analyse the effects of preoperative and postoperative metabolomics and hormonal changes on metabolic disease remission in patients with metabolic syndrome.
Compounds and methods for synthesizing oxysterol are provided. The compounds and methods provided allow for the safe production of oxysterol in high yields. The provided compounds and methods can produce oxysterol in a stereoselective manner. Compounds and methods for synthesizing Oxy133 are provided for promoting osteogenesis, osteoinduction, and/or osteoconduction. Also provided are methods of synthesizing Oxy133 with high yield and improved process safety. Methods for synthesizing stereoselective Oxy133 are also provided.
Patients receive alpelisib PO and enzalutamide PO on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.
Described herein are assistant robots that observe signs of core health, health dangers, and/or signs of medical distress in a home or at work. As such, the assistant robots can take actions to prevent dangerous situations, diagnose health problems, respond to requests for help, and provide regular treatments or analysis of a person's medical state. The assistant robots can learn users' habits or be provided with knowledge regarding humans in its environment. The assistant robots develop a schedule and contextual understanding of the persons' behavior and needs. The assistant robots may interact, understand, and communicate with people before, during, or after providing assistance. The robot can combine gesture, clothing, emotional aspect, time, pose recognition, action recognition, and other observational data to understand people's medical condition, current activity, and future intended activities and intents.
PURPOSE: A cosmetic composition for hair containing pearl-derived protein, phospholipid polymers, or sugar alcohol is provided to enhance volume or elasticity. CONSTITUTION: A cosmetic composition for hair contains pearl-derived protein and phospholipid polymers as active ingredients. The composition further contains sugar alcohol as an active ingredient. The pearl-derived protein is a hydrolysed conchiolin protein. The phospholipid polymers are a copolymer of 2-methacryloyloxyethyl phosphorylcholine and butylmethacrylate. The phospholipid polymer is polyquaternium-51. The sugar alcohol is xylitol. The composition contains 0.005-10.0 weight% of pearl-derived protein, 0.005-10.0 weight% of phospholipid polymers, 0.001-20.0 weight% of sugar alcohol based on total weight.
Rare neuromuscular diseases (NMDs) encompass various disorders of the nervous system and skeletal muscles, and present intricate challenges in diagnosis, treatment, and research due to their low prevalence and often diverse multisystemic manifestations. Leveraging collected patient data for secondary use and analysis holds promise for advancing medical understanding in this field. However, a certain level of data quality is a prerequisite for the methods that can be used to analyze data. The heterogeneous nature of NMDs poses a significant obstacle to the creation of standardized documentation, as there are still many challenges to accurate diagnosis and many discrepancies in the diagnostic process between different countries. This paper proposes the development of an information model tailored to NMDs, aiming to augment visibility, address deficiencies in documentation, and facilitate comprehensive analysis and research endeavors. By providing a structured framework, this model seeks to propel advancements in understanding and managing NMD, ultimately benefiting patients and healthcare providers worldwide.
BACKGROUND: Fibromuscular dysplasia is an idiopathic, segmental, nonatherosclerotic, noninflammatory vascular disease that can lead to arterial stenosis, tortuosity, occlusion, aneurysms, and dissection. Fibromuscular dysplasia is a rare cause of hypertension that can easily be missed. To date, there has been no definitive treatment for fibromuscular dysplasia.
CASE REPORT: In this report, we present an uncommon case of renovascular hypertension in a 21-year-old non-white female with a 3-year history of hypertension secondary to fibromuscular dysplasia involving bilateral renal arteries. Computed tomography angiography during the arterial phase revealed distal focal narrowing of the right main renal artery, distal focal narrowing of the left main renal artery, and proximal focal narrowing of the left accessory lower renal artery. Percutaneous balloon dilatation of the stenotic lesion was performed successfully up to 1 year After the procedure, the arterial blood pressure was within the normal range (110/70 to 125/75 mmHg) without medication. After 1 year of follow-up, CTA revealed re-stenosis in left main renal artery without clinical symptoms and normal blood pressure. Repeated procedure was done successfully.
CONCLUSIONS: This case report highlights the difficulty in the diagnosis and treatment of focal fibromuscular dysplasia in young non-white female patients. Computerized tomographic angiography is a useful tool for identifying the cause and showing the benefit of percutaneous transluminal renal angioplasty treatment for this rare entity, as an early percutaneous angioplasty intervention may have a clinical cure for hypertension.
This 5-8 session group intervention, "Integrating Nuanced Support for Perinatal adherence and Depression", aimed to decrease depressive symptoms and improve antiretroviral adherence among HIV-infected pregnant and postpartum women. Intervention content was based on two established cognitive-behavioral interventions: problem-solving therapy and Cognitive Behavioral Therapy for Adherence and Depression.
NEW MATERIAL:A physiologically active peptide having an inhibiting action on increase of toxoplasma, consisting of the amino acid sequence expressed by formula I-IV. EXAMPLE:Glycyl-penta-glutaminate. USE:A preventive and remedy for toxoplasma infections disease and an immunity activating drug. PREPARATION:For instance, a normal Holstein cow is intravenously inoculated with toxoplasma RH stock trophozoit mesosoma, 5 weeks later the same toxoplasma RH stock is administered, further 2 weeks later, toxoplasma lysate antigen (TLA) is intravenously administered and then 24hr later, blood of the cow is collected to give blood serum. Next, the blood serum is hydrolyzed with protease and purified by gel-filtration and ion-exchange chromatography to give ovioactin. Amino acid sequences of the ovioactin are analyzed and therefrom the amino acid sequence of the minimum structure at active site is estimated and a substance of the minimum structures synthesized by a well- known method to afford the compound expressed by the formula I-IV.