anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants enrolled in this arm will consume 300ml of water over 60 minutes. Each session will consist of 30 swallows broken into three 10-swallow sequences of 10ml of water. Sequences 1 and 3 will use videofluoroscopy only, while sequence 2 will use VFSS with simultaneous pharyngeal high resolution manometry in order to visualize swallows.
Chronic metabolic stress paradoxically elicits pro-tumorigenic signals that facilitate cancer stem cell (CSC) development. Therefore, elucidating the metabolic sensing and signaling mechanisms governing cancer cell stemness can provide insights into ameliorating cancer relapse and therapeutic resistance. Here, we provide convincing evidence that chronic metabolic stress triggered by hyaluronan production augments CSC-like traits and chemoresistance by partially impairing nucleotide sugar metabolism, dolichol lipid-linked oligosaccharide (LLO) biosynthesis and N-glycan assembly. Notably, preconditioning with either low-dose tunicamycin or 2-deoxy-D-glucose, which partially interferes with LLO biosynthesis, reproduced the promoting effects of hyaluronan production on CSCs. Multi-omics revealed characteristic changes in N-glycan profiles and Notch signaling activation in cancer cells exposed to mild glycometabolic stress. Restoration of N-glycan assembly with glucosamine and mannose supplementation and Notch signaling blockade attenuated CSC-like properties and further enhanced the therapeutic efficacy of cisplatin. Therefore, our findings uncover a novel mechanism by which tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation.
BACKGROUND: Risk stratification of cutaneous squamous cell carcinoma (cSCC) is essential for managing patients.
OBJECTIVES: To determine if artificial intelligence and machine learning might help to stratify patients with cSCC by risk using more than solely clinical and histopathological factors.
METHODS: We retrieved a retrospective cohort of 104 patients whose cSCCs had been excised with clear margins. Clinical and histopathological risk factors were evaluated. Haematoxylin and eosin-stained slides were scanned and analysed by an algorithm based on the stacked predictive sparse decomposition technique. Cellular morphometric biomarkers (CMBs) were identified via machine learning and used to derive a cellular morphometric risk score (CMRS) that classified cSCCs into clusters of differential prognoses. Concordance analysis, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were calculated and compared with results obtained with the Brigham and Women's Hospital (BWH) staging system. The performance of the combination of the BWH staging system and the CMBs was also analysed.
RESULTS: There were no differences among the CMRS groups in terms of clinical and histopathological risk factors and T-stage assignment, but there were significant differences in prognosis. Combining the CMRS with BWH staging systems increased distinctiveness and improved prognostic performance. C-indices were 0.91 local recurrence and 0.91 for nodal metastasis when combining the two approaches. The NPV was 94.41% and 96.00%, the PPV was 36.36% and 41.67%, and accuracy reached 86.75% and 89.16%, respectively, with the combined approach.
CONCLUSIONS: CMRS is helpful for cSCC risk stratification beyond classic clinical and histopathological risk features. Combining the information from the CMRS and the BWH staging system offers outstanding prognostic performance for patients with high-risk cSCC.
PURPOSE:A radiation sensitizer for increasing extremely susceptibility of inveterate low-oxygen cell existing in a malignant tumor to radiation, containing a specific dinitrobenzoic acid derivative as an active ingredient. CONSTITUTION:A radiation sensitizer containing a dinitrobenzoic acid derivative shown by the formula [R is OM1/a, OR1, N(R2)R3; M is metal of group I a or IIa; a=1 or 2; R1-3 are, H, alkyl, etc.; R2 and R3 are bonded each other to show alkylene, oxadialkylene, etc.] as an active ingredient. The compound shown by the formula is found to increase extremely susceptibility of low-oxygen cell to radiation and to enlarge radiation remedying effect on a malignant tumor. A dose is sufficiently <=1/50 that of misonidazole well-known as a sensitizer, and the compound has hardly toxicity with this amount of it.
FIELD: cosmetic industry. SUBSTANCE: invention deals with production of liquid cosmetic balsams which may be used for care of skin of face, hands, body and, also head and hair roots. Cosmetic balsam contains the following ingredients, mas.%: mixture of aqueous-alcoholic extracts of medicinal herbs as a biologically active additive, 5.0-20.0; oil extract of thyme, or pine, or camomile, 0.05-1.0; nipagin, 0.05-0.5; water, the balance. Biologically active additive comprises mixture of aqueous-alcoholic extracts of 33 species of medicinal plants taken in amount from 1.0 to 50.0 mas%. EFFECT: improved quality of liquid cosmetic agents, extended range of action to various types of skin. 1 cl, 2 tbl, 7 ex
The gut microbiome plays pivotal roles in various physiological and pathological processes, with key metabolites including short chain fatty acids (SCFAs), bile acids (BAs), and tryptophan (TRP) derivatives gaining significant attention for their diverse physiological roles. However, quantifying these metabolites presents challenges due to structural similarity, low abundance, and inherent technical limitations in traditional detection methods. In this study, we developed a precise and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method utilizing a chemical isotope derivatization technique employing 4-(aminomethyl)-N,N-dimethylaniline-d0/d6 (4-AND-d0/d6) reagents to quantify 37 typical gut microbiome-derived metabolites. This method achieved an impressive 1500-fold enhancement in sensitivity for detecting metabolites, compared to methods using non-derivatized, intact molecules. Moreover, the quantitative accuracy of our chemical isotope derivatization strategy proved comparable to the stable isotope labeled internal standards (SIL-IS) method. Subsequently, we successfully applied this newly developed method to quantify target metabolites in plasma, brain, and fecal samples obtained from a neonatal hypoxic-ischemic encephalopathy (HIE) rat model. The aim was to identify crucial metabolites associated with the progression of HIE. Overall, our sensitive and reliable quantification method holds promise in elucidating the role of gut microbiome metabolites in the pathogenesis of various diseases.
PURPOSE:To obtain a circulation improving agent having circulation improving action and cell-activating action in hypoxic state and useful as a preventive and remedy for various diseases caused by circulatory hypofunction by using phytic acid and its salt as active component. CONSTITUTION:At least one kind of compounds selected from phytic acid and its salt is used as an active component of the present agent. Phytic acid is widely distributed in plants in the form of Ca, Mg or potassium salt. For example, rice bran contains as much as 9.5-14.5% of phytic acid. Phytic acid salt used in the present agent is potassium salt, sodium salt, etc. When the agent is to be orally administered in principle, it is preferable to use the phytic acid in the form of various salts having a pH of about 6-8 from the viewpoint of taste, etc., and the salt is properly selected according to the use (e.g., circulation improving agent, circulation-improving functional food, drink or tasteful food) and used singly or in combination.
After obtaining written consent, participants will be asked to download and use the Calm meditation smartphone application everyday for a 30-day period. Participant demographics and clinical information will be collected at baseline. Participants will additionally be asked to complete questionnaires concerning health-related quality of life (HRQoL) as well as mental health, stress, and self-efficacy at baseline and at the end of the 30 day study period. A brief check-in via telephone will be conducted on day 15.

Participants using the calm app will be compared to participants receiving usual care who will be asked to complete identical sets of questionnaires. The participant may choose whether they join the Calm application vs usual care (questionnaires only) group on a voluntary basis; there is no pre-assignment. The Calm application is a publicly available program that is available to any patient independent of this study.
BACKGROUND AND OBJECTIVES: Therapeutic hypothermia has reduced the risk of death or major disability following perinatal hypoxic-ischemic encephalopathy (HIE); however, many children who experience perinatal HIE still go on to develop personal and behavioral challenges, which can be difficult for caregivers and a public health burden for society. Our objective with this review is to systematically identify and synthesize studies that evaluate associations between perinatal HIE and socioemotional or psychological outcomes.
METHODS: We screened all search-returned journal articles from Cochrane Library, Embase, Medline, PsycINFO, Scopus, and Web of Science from data inception through February 1, 2023. Keywords related to HIE (eg, neonatal encephalopathy, neonatal brain injury) and outcomes (eg, social*, emotion*, behav* problem, psycholog*, psychiatr*) were searched with a predefined search string. We included all observational human studies reporting socioemotional or psychological sequelae of term HIE. Study data were recorded on standardized sheets, and the Newcastle-Ottawa Scale was adapted to assess study quality.
RESULTS: We included 43 studies documenting 3244 HIE participants and 2132 comparison participants. We found statistically significant associations between HIE and social and emotional, behavioral, and psychological and psychiatric deficits throughout infancy, childhood, and adolescence (19 studies). The authors of the included studies also report nonsignificant findings (11 studies) and outcomes without statistical comparison (25 studies).
CONCLUSIONS: Perinatal HIE may be a risk factor for a range of socioemotional and psychological challenges in the short- and long-term. Routine screening, early intervention, and follow-up support may be particularly beneficial to this population.
To reduce a lot of time and effort on renewal or adjustment of a facility for identifying a person, even if layout change etc. of an office occurs, when managing seat occupancy information relating to a seat occupancy situation of the person, in the office of a free address system, and further, efficiently collect information etc. relating to the person's health.SOLUTION: A seat occupancy information management system comprises an indoor camera 1 and an information collection robot 2. Based on a captured image of the indoor camera, when a person's seat occupancy is detected, the information collection robot moves to the vicinity of the person in which the seat occupancy has been detected, is controlled to photograph the person's face by a face camera, performs face collation processing by using the captured image of the face camera, and generates seat occupancy information relating to the person identified by the face collation processing. Moreover, based on the captured image of the face camera, information on the presence or absence of wearing of a mask relating to the person is generated. Moreover, by a vital sensor of the information collection robot, processing for measuring the person's vital information is performed.SELECTED DRAWING: Figure 2
This is a cohort of 150 subjects who were previously enrolled in the Neonatal Seizure Registry, a multi-center association of institutions across the United States, They were contacted to participate in the study after discharge from the Neonatal Intensive Care Unit (NICU) but prior to the prospective follow up. They were asked to take part in all prospective follow up surveys at 12, 18, \& 24 months of age.
Prostate cancer (PC) is common among men and has become a significant societal issue. Localized PC has a good prognosis with appropriate treatment. Prostatectomy, particularly robot-assisted radical prostatectomy (RARP), has become a common treatment since the da Vinci prostatectomy was approved by the FDA in 2001. The current study aimed to assess the learning curve for RARP, focusing on anastomosis time, using the cumulative sum (CUSUM) method. Data were collected from Nagoya City University Hospital between May 2011 and December 2018 and included 469 surgeries performed by experienced surgeons. Our findings indicated that, on average, 11 patients were required to complete the initial phase and 24 patients were required to complete the consolidation phase of anastomosis. Additionally, for complete resection of pT2c cases, 16 cases were required for the initial phase and 27 cases were required for the consolidation phase. The CUSUM method proved useful for visualizing trends in surgical proficiency, although the study noted potential confounding biases and limitations in evaluating surgical proficiency based solely on surgical time or positive surgical margins.
1. The veterinary product for a single application contains an antibacterial preparation, an adjunctive anti-inflammatory agent and, possibly, a physiologically acceptable medium liquid or carrier. It is characterised in that it contains a therapeutically effective amount of an oxytetracycline preparation with prolonged action and an effective amount of adjunctive flunixin. The product is designed for parenteral application. 3. The method of producing the veterinary product for a single application, which contains an antibacterial preparation, an adjunctive anti-inflammatory agent and, possibly, a physiologically acceptable medium liquid or carrier. It is characterised in that the oxytetracycline preparation with prolonged action is introduced, together with a pre-established amount of flunixin, into a homogenous mixture. The obtained homogenous mixture is prepared for parenteral application.
The invention relates to stomatology and perfume industry in particular to therapeutic formulation for oral cavity care. The invention refers to oral hygiene means and can be applied for preparation of medical and prophylactic tooth-pastes, gels, liquids for oral care as well as other compositions like chewing gums, jellies, etc. Formulation containing orally applicable active and inert components involves bromelain in amount of 0.01÷1 wt %, xylitol 1.5÷20 wt %. At best bromelain content is 0.1—0.8 wt %, xylitol content—2.2-18 wt %. For attaining remineralizing effect formulation contains anti-carious mineral additive 0.05-3.0 wt % of the list of active components. At best anti-carious mineral additive content is 0.2-2.5 wt %. There are used calcium glycerophosphate and inorganic or organic magnesium salt as anti-carious mineral additive. It is acceptable to use sodium monofluorphosphate, potassium monofluorphosphate, calcium monofluorphosphate or magnesium monofluorphosphate in amount of 0.5-1.5 wt % as anti-carious mineral additive Optimum concentration is 0.8-1.1 wt %.
PURPOSE: Recurrent miscarriage (RM) is a significant reproductive concern affecting numerous women globally. Genetic factors are believed to play a crucial role in RM, making the histidine-rich glycoprotein (HRG) gene, a topic of interest due to its potential involvement in angiogenesis. This study is aimed at investigating the association between the HRG rs10770 genotype and RM.
METHOD: Blood samples were collected from a total of 200 women at the beginning of the study. Subsequently, a comparative analysis was conducted between the blood samples of 100 women with a history of RM (case group) and the blood samples of another 100 healthy women (control group). HRG rs10770 genotyping was performed through polymerase chain reaction restriction-fragment length polymorphism (PCR-RFLP), followed by statistical analysis to evaluate the relationship between HRG rs10770 genotype and RM.
RESULTS: The results indicated a significant statistical difference between the C/C genotype (OR = 3.32, CI: 1.22-9.04, p = 0.01) and the C/T genotype (OR = 1.24, CI: 0.67-2.30, p = 0.47) in both the case and control groups. Additionally, a significant correlation was observed in the C allelic frequency among RM participants compared to the control group (OR = 1.65, CI: 1.06-2.58, p = 0.02).
CONCLUSION: The study highlights the importance of HRG rs10770 in understanding RM, shedding light on its implications for reproductive health. Furthermore, it became evident that women carrying the homozygous C/C genotype exhibited increased susceptibility to the risk of RM.
The invention aims to provide a Muscovy duck parvovirus. The Muscovy duck parvovirus is a YBMDV strain, and is preserved in the China General Microbiological Culture Collection Center of the China Committee Of Culture Collection For Microorganisms in the Institute of Microbiology Chinese Academy of Science at the address of No. 3, No. 1 yard, Beichen west road, Chaoyang District, Beijing, on November 11th, 2013; the preservation number is CGMCC No. 8504. The Muscovy duck parvovirus screened by the invention has the characteristics of low toxicity and high immunogenicity; dead embryo and embryo liquid can be obtained by vaccinating the Muscovy duck parvovirus to a Muscovy duck embryo; virus liquid can be collected after grinding and freeze thawing; a vaccine is prepared by ultrafiltration concentration, formalin inactivation, the addition of an adjuvant, and mixing and emulsification; the Muscovy duck parvovirus can improve antibody of the Muscovy duck, ensure parent source antibody level of an offspring, and prevent green duck parvovirus infection caused by Muscovy duck parvovirus; the vaccine has the advantages of high efficiency and good safety.
FIELD: heterocyclic compounds, can be used in medicine. SUBSTANCE: the synthesis is effected by reacting 7-oxy-4-fluoroisoflavone with cinnamic acid chloride in pyridine on heating (1.5 hr) followed by treatment of the reaction mixture with an aqueous solution of acetic acid. The yield 75.5%, mp 212-213 C, the empirical formula: CHFO. The hypotensive activity of the new compound when injected subcutaneously (100 mg/kg) is by 2 times higher than of theobromine and by 1.6 higher than that of the structural analogues by the 60th minute. EFFECT: new more active compounds of said class. 1 tbl
In sustained stretching against the wall, individuals will be asked to place their hands on the wall at shoulder width apart. One leg will be positioned behind the other. Then, the front knee will be bent while keeping the back knee in extension and the heel in contact with the ground. Individuals will be instructed to bend their knees until they feel a stretch in the calf muscle. Subsequently, they will be asked to maintain this position for 3 minutes. The stretching exercise will be performed in 3 sets per day.
PURPOSE: Obesity is one of the lifestyle disorders which is slowly and steadily extending throughout the world. Women especially are showing an upward shift in Body mass index (BMI) in this modern era. Obesity in females has been associated with various risk factors. Less studies have been explored on the influence of BMI on different parameters of menstrual cycle The purpose of the study was to determine the influence of BMI on different parameters of the menstrual cycle.
METHODS: A total of 50 healthy female volunteers with regular menstrual cycle were selected after prior consent, and among them based on the body mass index, 32 females were categorized into obese group based on the BMI. Menstrual cycle history was monitored for 3 months for confirming regularity. Serum Progesterone and Peak expiratory flow rate (PEFR) were recorded.
RESULTS: Progesterone levels were very highly significant in the luteal phase when compared to early follicular and ovulatory phase. The PEFR value in luteal phase was higher when compared to early follicular and ovulatory phase which was statistically highly significant. Positive correlation between progesterone and PEFR was observed in the luteal phase, but it was not statistically significant. Positive correlation between BMI and PEFR was also observed.
CONCLUSION: The study reveals significant hormonal and respiratory changes throughout the menstrual cycle. Progesterone levels and PEFR are markedly higher in the luteal phase, while BMI positively correlates with PEFR. A significant negative correlation exists between Waist Hip ratio (WHR) in the luteal phase. Further studies are needed to explore the underlying mechanisms driving the correlations between progesterone, respiratory parameters, BMI, and WHR in more diverse population.
The invention provides functional Ziyu Chinese yam and fruit composite juice and a preparation method thereof, belonging to the technical field of fruit juice processing. The composite juice is prepared from the following raw materials in parts by weight: 20-35 parts of Ziyu Chinese yam, 8-15 parts of red pitaya pulp, 10-18 parts of mulberry fruits, 8-15 parts of red beans, 12-20 parts of color fixative, 2-5 parts of stabilizer, 15-50 parts of sweetening agent, 2-8 parts of acidity agent, 0.2-0.3 part of alpha-amylase, 0.2-0.4 part of glucoamylase, 0.15-0.25 part of cellulase, 0.15-0.25 part of protease, 0.02-0.03 part of pectase and 360-650 parts of water. The fruit juice has efficacy of nourishing yin, supplementing blood, tonifying spleen, nourishing stomach, maintaining beauty and keeping young. With the adoption of the preparation method, nutrition and fragrance of each component can be well kept. A purple color can be kept due to the addition of the suitable color fixative. In addition, the produced beverage is uniform, fine and smooth in texture, and is sour, sweet and delicious in taste without precipitation.
Jasmiel is also indicated for the treatment of symptoms of premenstrual dysphoric disorder (PMDD) in females of reproductive potential who choose to use an oral contraceptive as their method of contraception. The effectiveness of Jasmiel for PMDD when used for more than three menstrual cycles has not been evaluated.

  


The essential features of PMDD according to the Diagnostic and Statistical Manual-4th edition (DSM-IV) include markedly depressed mood, anxiety or tension, affective lability, and persistent anger or irritability. Other features include decreased interest in usual activities, difficulty concentrating, lack of energy, change in appetite or sleep, and feeling out of control. Physical symptoms associated with PMDD include breast tenderness, headache, joint and muscle pain, bloating and weight gain. In this disorder, these symptoms occur regularly during the luteal phase and remit within a few days following onset of menses; the disturbance markedly interferes with work or school, or with usual social activities and relationships with others. Diagnosis is made by healthcare providers according to DSM-IV criteria, with symptomatology assessed prospectively over at least two menstrual cycles. In making the diagnosis, care should be taken to rule out other cyclical mood disorders.

  


Jasmiel has not been evaluated for the treatment of premenstrual syndrome (PMS).
Participants will complete the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7 instruments virtually. Participants will then complete a video recorded virtual Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders-5.