anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: With the increasing survival rate of smaller newborns and twins, previous growth curves may not accurately assess the growth of extremely preterm infants (EPIs). Our study aimed to establish birth weight percentile curves for singletons and twins in EPIs from China and the USA and compare the differences between them.
METHODS: In China, EPIs were from 31 provinces, from 2010 to 2021. The collected information was sex, gestational age, birth weight, singletons and twins. We used the generalised additive models for location scale and shape method to construct the birth weight percentile curves by gestational age and sex for EPIs. The National Vital Statistics System database from 2016 to 2021 was also analysed. We compared the differences between the 50th birth weight percentile curves of the two databases.
RESULTS: We identified 8768 neonates in China (5536 singletons and 3232 twins) and 121 933 neonates in the USA (97 329 singletons and 24 604 twins). We established the 3rd, 10th, 25th, 50th, 75th, 90th and 97th birth weight reference curves for China and the USA. The results showed that males had higher birth weights than females. In China, for the same gestational age and sex, birth weights in singletons and twins were found to be similar, though singleton males born in China had slightly higher birth weights than male twins. In the USA, birth weights were also similar for females and males, with the same gestational age in singletons and twins.
CONCLUSION: We established birth weight reference percentile curves by gestational age and sex for singletons and twins among EPIs in China and the USA.
BACKGROUND: There is no evidence to determine the association between the lactate dehydrogenase to albumin ratio (LAR) and the development of sepsis-associated acute kidney injury (SAKI). We aimed to investigate the predictive impact of LAR for SAKI in patients with sepsis.
METHODS: A total of 4,087 patients with sepsis from the Medical Information Mart for Intensive Care IV (MIMIC IV) database were included. Logistic regression analysis was used to identify the association between LAR and the risk of developing SAKI, and the relationship was visualized using restricted cubic spline (RCS). The clinical predictive value of LAR was evaluated by ROC curve analysis. Subgroup analysis was used to search for interactive factors.
RESULTS: The LAR level was markedly increased in the SAKI group (p < 0.001). There was a positive linear association between LAR and the risk of developing SAKI (p for nonlinearity = 0.867). Logistic regression analysis showed an independent predictive value of LAR for developing SAKI. The LAR had moderate clinical value, with an AUC of 0.644. Chronic kidney disease (CKD) was identified as an independent interactive factor. The predictive value of LAR for the development of SAKI disappeared in those with a history of CKD but remained in those without CKD.
CONCLUSIONS: Elevated LAR 12 h before and after the diagnosis of sepsis is an independent risk factor for the development of SAKI in patients with sepsis. Chronic comorbidities, especially the history of CKD, should be taken into account when using LAR to predict the development of AKI in patients with sepsis.
PURPOSE: To improve an effect of accelerating healing of a wound by successively superposing chitosan, alginic acid, chitin and supporting body on each other, thereby forming a laminated body for treating the wound. CONSTITUTION: This laminated body for treating the wound is formed by forming a layer 1 in contact with the wound surface of the chitosan, a layer 2 in contact with the layer 1 of the alginic acid, the layer 3 of the chitin and the outermost layer 4 of the supporting body. Cotton-like chitosan is used for the chitosan, nonwoven fabric-like alginic acid metal salt for the alginic acid, the cotton-or sponge-like chitin for the chitin and aluminum gauze for the supporting body. The chitin has N-acetyl-D-gluocosamine and D-glucosamine as the constituting monosaccharide and the ratio of the D-glucosamine is <=30%. The chitin is otherwise polysaccharides consisting of only the N-acetyl-D- gluocosamine and is obtd. from the shells of crabs and prawns, the cartilage of cuttlefish, the exoskeleton of Insecta, or the cell walls, etc., of mushroom and bacterium.  The chitosan is formed by treating the chitin with an alkaline soln. of a high concn. to deacetylate the chitin.
Participants in this arm will receive 6 telephone therapy sessions and 1 booster session. Participants will be followed up at 4 months and 6 months.
FIELD: medicine, ophthalmology. SUBSTANCE: free-radical oxidation occurring in living organisms that is responsible for development of pathological states is inhibited by antioxidants that convert radicals to low-active compounds, break chain reactions and exclude or diminish the negative effect of prooxidants on physiological processes. This problem can be solved by using ophthalmic drops containing the complex comprising of 9 antioxidant preparations: unithiol, zinc sulfate, ascorbic acid, vitamin E in 20% albumin solution, uric acid, allopurinol, dimethylsulfoxide, 96 °  ethyl alcohol and sodium selenite. The use of ophthalmic drops in treatment of different stages of endothelial-epithelial dystrophy ensures to recover epithelium defect more effectively and rapidly, to arrest symptoms of cornea syndrome (pain, photophobia, lacrymation) and to enhance vision sharpness. EFFECT: enhanced effectiveness of ophthalmic drops, valuable medicinal properties. 1 cl, 2 tbl, 2 ex
All needle punctures will be guided by ultrasound (US). The puncture needle is a 3.8cm 22# needle attached on a 5ml syringe. Before puncture, the skin of the puncture site will be sterilized with better iodine, and the transducer will be covered with a sterilized plastic bag. After injecting 3cc 1% Xylocain in the subcutaneous tissue, muscle layer and subdeltoid bursa, multiple back-and-forth puncture about 10-20 times (depending on the size of the plaques) within the calcific plaques will be performed. The needle tract will be monitored by ultrasound to make sure the needle penetrated through the calcific plaque, but does not penetrate the rotator cuff.
The present invention relates to a mist composition having an aromatherapeutic effect, comprising natural oil including essential oil of Dendranthema boreale (Makino) Ling ex Kitam., essential oil of Citrus junos Sieb. ex Tanaka, essential oil of Artemisia princeps Pampanini in Geomundo Island, and essential oil of Artemisia annua; and natural hydrosol including hydrosol of Dendranthema boreale (Makino) Ling ex Kitam., hydrosol of Citrus junos Sieb. ex Tanaka, hydrosol of Artemisia princeps Pampanini in Geomundo Island, hydrosol of Artemisia annua, and hydrosol of ginseng. The natural hydrosol is added as a solvent. The mist composition has a combination of Dendranthema boreale (Makino) Ling ex Kitam. flower scent and Artemisia princeps Pampanini scent, has anti-bacterial and anti-atopic effects, relieves the skin, moisturizes the skin, and has an aromatherapeutic effect.
Participants in the CG will maintain their usual team training routines and practices throughout the study period, without receiving any additional training interventions. They will serve as a reference to compare the effects of the plyometric, functional, and WB-EMS training programs on athletic performance and health-related outcomes. Participants in this group will undergo all scheduled assessments at baseline, after each 8-week intervention period, and during the follow-up to track changes in their performance and health status over time. The control group will help determine the extent to which changes in the intervention groups can be attributed to the specific training programs, rather than other factors such as natural progression or regular team training.
This is a prospective, randomized, dual arm, pragmatic trial in a real-world setting to evaluate the effectiveness and health economics outcomes of the Cala Trio device in reducing hand tremor and improving quality of life as measured by the Bain and Findley Activities of Daily Living (ADL) score relevant to the stimulated upper limb. Healthcare resources utilization and total all-cause healthcare will also be evaluated. The study will recruit approximately 300 patients: 150 in the intervention arm (Cala Trio device)and 150 patients in the standard of care (SOC) arm. Subjects will be randomized to either the intervention arm or the standard of care arm (1:1).Subjects in the SOC arm will be asked to measure their tremor severity by doing daily postural holds with the Cala Trio device without actual stimulation. Subjects in the intervention arm will wear the device at home for a period of 12 months, during which they will deliver 40 min stimulation sessions, which can be started and stopped on demand. After the first month, the subjects who were randomized to the SOC arm will cross over to the intervention arm.
Diabetic kidney disease is increasing in prevalence and is associated with significant morbidity and mortality. Health disparities exist in the progression of diabetic kidney disease, with minorities being more affected even when adjusting for treatment, glycemic and hypertensive control, and medical coverage. Secondary prevention of the progression of diabetic kidney disease is hindered by a lack of easily modifiable risk factors. Based on animal and observational human studies, vitamin D deficiency is potentially a novel, modifiable risk factor that may interrupt or delay the progression of diabetic kidney disease through direct effects as well as by helping to ameliorate kidney disease risk factors, such as hyperglycemia, hypertension and inflammation. In addition, based on minorities having a higher prevalence of vitamin D deficiency, it may also potentially impact the differential progression of diabetic kidney disease in minorities. However, clinical trials evaluating the impact of vitamin D supplementation on diabetic kidney disease are lacking. Thus, this pilot study funded as an R03 through the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) has the following specific aims: (1): To evaluate the impact of vitamin D supplementation (vitamin D3 at 400 IU/d versus 4000 IU/d) on the proportion of individuals with progression of albuminuria over 12 months in a sample of African American participants with vitamin D deficiency in a randomized controlled trial. (2): To identify whether kidney disease risk factors such as blood pressure and glycemic control mediate the impact of vitamin D supplementation on the progression of albuminuria over 12 months in a sample of African American participants with vitamin D deficiency in a randomized controlled trial.
If the Recommended Phase II Dose (RP2D) for Venetoclax during induction is established, then the dose-expansion cohort would continue to test venetoclax in both induction and maintenance. Participants would be administered non-continuous induction therapy with Venetoclax (RP2D-I/induction RP2D), Atezolizumab (1200mg) every 3 weeks (Q3W) on Day 1, Carboplatin (5mg/mL/min) on Day 1 and Etoposide (100mg/m\^2) on Days 1-3 followed by continuous maintenance therapy with Venetoclax (RP2D-M) and Atezolizumab (1200mg) every 3 weeks (Q3W) on Day 1. If significant toxicity and DLTs in induction precluded identification of an RP2D for venetoclax in induction treatment, then the safety and efficacy of venetoclax would only be investigated in dose-expansion in the maintenance setting. Participants would be administered continuous maintenance therapy with Venetoclax (RP2D-M) and Atezolizumab (1200mg) every 3 weeks (Q3W) on Day 1.
This study aims to find relationships between food insecurity, vitamin D intakes and its impact on metabolic syndrome among older adults in a city in Alborz province in Iran, known as Karaj. This study has 2 parts; the first part is to determine the prevalence of food insecurity and vitamin D deficiency among older adults in Karaj city. The second part is an intervention study examining effects of vitamin D supplementation on metabolic syndrome (diabetes, obesity, hypertension, and dyslipidaemia) among older adults who have at least have risk factors of metabolic syndrome, food insecure and vitamin D deficient. The first part; the data collection process will be performed in a few stages. The first stage will be to initiate contacting with the health centres in Karaj city to identify the older adults. Appointments will be set after screening the study subjects who will be eligible. Consent will be obtained from those who were eligible. The preliminary information on demographic data, socioeconomics, food insecurity, dietary intake and sunlight exposure will be collected by using a set of questionnaires. The blood sample for measuring serum 25 (OH) D will be taken the same day as questionnaires were filled.

The second stage: The data collection process will be performed in few stages. The first stage will include of contact with health centres in Karaj city to identify the older adults for both groups; intervention and control. Consent will be obtained from those who will eligible. Anthropometric measurement (height, weight, body mass index, and waist circumference), blood pressure measurement, blood taking and three-day food record will be obtained during baseline from all study respondents in the intervention and control groups.
The research will include the parents of 194 children with special needs between the ages of 6-18, who came to four special education and rehabilitation centers in Efeler district of Aydın province between 13 September 2021 - 22 May 2022 (8 months) and were selected by stratified random sampling method.

Study data will be collected from the parents of children coming to Rehabilitation Centers and routine training by face-to-face interview technique using the child and parent information form and the Oral and Dental Health Information Evaluation Form. Data collection is expected to take approximately 15-20 minutes.

Approval will be obtained from Aydın Adnan Menderes University Faculty of Nursing Non-Interventional Research Ethics Committee to conduct the research. Permission will be obtained from the institutions to conduct the research in the centers. An explanation about the research will be made to the parents (mother or father) of the children who meet the sampling criteria, and written consent will be obtained from the parents of the children who agree to participate in the research.

While calculating the sample size, the self-efficacy perception score averages in the study titled "The effect of learning objects on academic success, self-efficacy perception, motivation and learning permanence in mathematics teaching" were used according to effect power calculation blended standard deviation. was placed on the formula and the potency was calculated (d: 13.11). Two independent groups and t test options were selected through G power analysis and power analysis was calculated according to the two-way hypothesis method. According to the previous study, when the significance level between the study group and the control group was taken as α = 0.05 and the power of the test was 1-β = 0.95, the sample size to be selected was determined as 56 people for each group. It was determined that the sample loss (students registered for the 2018-2019 spring semester who failed due to absence and failure) was approximately 15% due to the fact that among our exclusion criteria for the study were students who failed due to absence and failure. By increasing the minimum number of students planned to be included in the research and required to be in each group (n=56+0.15) by 15% (approximately 8 students), the number of samples for both groups became 64 (study group; n=64; control group n=64). It was calculated as a total of 128 students. A post-hoc power analysis will be conducted after the study. The data of the research will be analyzed using SPSS 25 (Statistical Package for the Social Sciences) program. Descriptive statistics, Chi-square test, Student-T test will be used to evaluate the study data. Student's T Test will be used to compare paired groups in the analysis of normally distributed dependent variables. Mann-Whitney U test will be applied to compare two independent data that do not show normal distribution. Values at P\<0.05 will be considered statistically significant. Regression analysis will be performed to determine factors that may be related to dependent variables.
PROBLEM TO BE SOLVED: To provide the subject new compound having strong serotonin 2 receptor antagonistic action and excellent separation from central action and useful for the prevention and treatment of circulatory diseases. SOLUTION: This compound is expressed by formula I (R<1> and R<2> are each, H, a lower alkyl, a lower alkoxy or a halogen; X is O or S; A is CR<3> (CN), the group of formula II, etc.; R<3> is a lower alkyl, an alkenyl, etc.; (n) is 1-4), e.g. α- 1-(2-phenethyl)-4-piperidylidene}benzoxazol-2-ylacetonitrile hydrochloride. The compound of formula III with a compound of the formula; R<3> Y (Y is a halogen) in the presence of a base.  The compound of the formula I has strong platelet aggregation suppressing action especially by oral administration and is useful for the prevention and treatment of ischemic cardiopathy such as arrhythmia, heart failure, stenocardia and myocardial infarction, cerebrovascular disorders such as cerebral, infarction and transient ischemic attack, diseases caused by peripheral circulation disorder such as Raynaud disease and Buerger disease, hypertension, etc.
With advancing age, adults experience increasing difficulties in understanding speech in challenging situations, such as difficulty with understanding others in a noisy restaurant. Speech-in-noise difficulties are typically rehabilitated by providing hearing aids. For older normal-hearing adults, however, hearing devices do not provide much benefit since these adults do not have decreased hearing sensitivity. For these adults, communication difficulties persist in everyday life situations and can even lead to social withdrawal, isolation, and depression. A growing body of studies demonstrates that combined auditory-cognitive training paradigms can offer speech-in-noise benefits to adults with hearing loss that could prevent the consequences listed above.

The goal of the "Speech Perception with High Cognitive Demand" project is to evaluate the benefit of a new auditory-cognitive training paradigm for older normal-hearing adults. The investigators developed an American English version of the Nottingham (UK) PLUS training paradigm in which listeners are asked to focus and listen to one speaker while ignoring another speaker. Although it cannot ensure that every participant will experience direct significant benefit from the training, the paradigm is being designed to optimally enhance the possibility of benefit: an adaptive procedure is employed to train each individual at their own level and to make the task challenging. In a separate training condition, a short-term memory component is added to the original training paradigm to also enhance the cognitive skills of the participants. In addition, the training is implemented on touch-screen laptops, making at-home training possible. This way, training is provided in a realistic setting which will ensure a better transfer of the trained skills to daily communication situations. The trial consists of three conditions: 1) Auditory only training, 2) Auditory-cognitive training, and 3) Active control of informational videos.
PURPOSE:To exactly execute a diagnosis and to shorten the diagnostic time by inferring an inspection image in the past having an image list parameter corresponding to an image list parameter of an unread shadow image in the kind of an inferred image list. CONSTITUTION:In a work station 4, from an unread shadow image displayed on an image display means 9, a desired unread shadow image is selected by an image switching means 14. Subsequently, based on the kind of an inspection contained in inspection data of the unread shadow image, the kind of an image list to the inspection image in the past is determined. Next, under the kind of this determined image list, this time an inspection image in the past having a parameter having the closest relation (corresponding) to this image is inferred by using an image list parameter of the unread shadow image. Moreover, an inspection image having an inspection kind/image list parameter is called from a data base 3. In this case, image display means 10a, 10b have a relation to a shadow read image, and by executing comparison and shadow reading, a diagnosis is executed exactly, and the diagnostic time can be shortened.
This study employs a convergent parallel mixed methods design. The quantitative part involves a questionnaire survey using purposive and snowball sampling methods, inviting 400 caregivers of children with medical complexity (CMC) to participate. Stratified sampling is then applied, with 62 samples selected per age group (1-5 years, 6-10 years, 11-15 years, 16-20 years), resulting in a total of 248 valid samples. The aim is to measure the correlations among caregiver burden, quality of life, family functioning, and family resilience. For the qualitative research, purposive and snowball sampling methods are also used to recruit 10 caregivers of CMC from different age groups who meet the inclusion criteria and agree to participate. These caregivers undergo semi-structured in-depth interviews, with interview content recorded to gain deeper insights into their experiences and feelings regarding caregiver burden, quality of life, family functioning, and family resilience. The study instruments include validated tools such as the Caregiver Burden Inventory (CBI), SF-12 Health Survey for quality of life, the APGAR Family Functioning Scale, and a Chinese version of the Family Resilience Scale. Qualitative data are collected through semi-structured interviews. Data analysis involves descriptive statistics, analysis of variance (ANOVA), and multiple linear regression models using IBM SPSS Statistics 27 for quantitative data. Qualitative data are analyzed using textual and thematic analysis methods, supported by NVivo qualitative analysis software. Finally, data triangulation is employed to integrate and compare quantitative and qualitative findings, leading to conclusions and recommendations.
<P>PROBLEM TO BE SOLVED: To provide an osteogenesis promoting agent to promote osteogenesis, an osteoporosis preventing agent useful for the prevention of osteoporosis by promoting osteogenesis and a collagen synthesis promoting agent to promote the synthesis of collagen.  <P>SOLUTION: The osteogenesis promoting agent, the osteoporosis preventing agent and the collagen synthesis promoting agent contain royal jelly or its extract as an active component. The osteoporosis preventing agent promotes osteogenesis and exhibits the action for the prevention or amelioration of especially senile osteoporosis. The osteoporosis preventing agent preferably further contains a bone resorption suppressing agent and/or a food material having calcium supplementing action. The collagen synthesis promoting agent increases the expression quantity of procollagen 1α1 gene by mixing with ordinary feed and orally administering to mouse (refer to the Example 1 shown in the Figure). The gene is known as a differentiation marker of osteoblast and plays an important role for improving osteogenesis function because the gene codes type-I procollagen which is a precursor of type I collagen constituting the main protein of bones.  <P>COPYRIGHT: (C)2007,JPO&INPIT
This is the active control group. Participants will meet three times a week for strength, flexibility, and balance exercises for approximately 60 minutes per session, over 24 weeks (approximately 6 months).