anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To use an extracted material of Natto (fermented soybean) rich in nutrition, having improved moisture retention and lubricating effect, showing no offensive smell of Natto, as a cosmetic, drink or tonic, by using edible Natto as a raw material, extracting it by a simple operation to give the extracted material. CONSTITUTION:Water is added to sterilized Natto, which is ground, the filtrate is taken out, and a solvent immiscible with water is added to it. It is stirred, allowed to stand in a cold and dark place, and separated into the water layer part A and the solvent layer part B. A solvent miscible with water is added to A, which is stirred, allowed to stand in a cold and dark place, separated into the precipitate C and the supernatant liquid D, which are taken out separately. The solvent and water is removed from C to give a sold material, while an extracted material comprising an dyestuff component consisting essentially of isoflavon is obtained from D. The solvent is removed from B, which is saponified, to give an extracted material consisting essentially of phytosterol. A cosmetic containing C alone or C and B and/or D is used.
Headache is a common condition with a substantial burden of disease worldwide. Concerns have been raised over the potential impact of long-term mobile phone use on headache due to radiofrequency electromagnetic fields (RF-EMFs). We explored prospectively the association between mobile phone use at baseline (2009-2012) and headache at follow-up (2015-2018) by analysing pooled data consisting of the Dutch and UK cohorts of the Cohort Study of Mobile Phone Use and Health (COSMOS) (N = 78,437). Frequency of headache, migraine, and information on mobile phone use, including use of hands-free devices and frequency of texting, were self-reported. We collected objective operator data to obtain regression calibrated estimates of voice call duration. In the model mutually adjusted for call-time and text messaging, participants in the high category of call-time showed an adjusted odds ratio (OR) of 1.04 (95 % CI: 0.94-1.15), with no clear trend of reporting headache with increasing call-time. However, we found an increased risk of weekly headache (OR = 1.40, 95 % CI: 1.25-1.56) in the high category of text messaging, with a clear increase in reporting headache with increasing texting. Due to the negligible exposure to RF-EMFs from texting, our results suggest that mechanisms other than RF-EMFs are responsible for the increased risk of headache that we found among mobile phone users.
FIELD: medicine. SUBSTANCE: invention relates to development of complex homeopathic agents for maxillary sinusitis treatment. Proposed agent has Hydrastis canadensis C3, Kalium bichromicum C3, Pulsatilla pratensis C3, Thuja occidentalis C3, Phytolacca americana C3 and Acidum silicium C6 being all components are taken in equal doses. Agent can be made as sugar granules. Treatment with proposed agent ensures to eliminate typical symptoms of maxillary sinusitis: dull pains and heaviness in head, lacrimation, nose breathing disorder, phothophobia, disorder of sense of smell in damaged site. Nose secretions are decreased and then disappeared, body temperature is normalized, suppurative components are removed from median nose way, edemas of upper and lower eyelid are disappeared. EFFECT: enhanced effectiveness of drug. 2 cl, 1 ex
ARFI-SWV Ultrasound holds promise as an inexpensive, noninvasive, point-of-care diagnostic tool for pre-operatively predicting successful hernia repair. The investigators propose to develop and refine a quantitative ultrasound protocol to measure abdominal wall features suitable for predicting successful closure of the midline fascia. ARFI-SWV ultrasound represents a novel and intriguing modality for real time visualization and characterization of changes in the biomechanical properties of diseased musculoskeletal tissues.

In this study, ARFI-SWV ultrasound is hypothesized to preoperatively measure the stiffness in the lateral abdominal wall as an estimation for mobility during hernia repair. Preoperatively evaluating hernia severity through ARFI-SWV ultrasound will be performed to identify mechanical characteristics of the abdominal musculature to predict success of midline fascial re-approximation in hernia patients. The study proposes to compare ultrasound images and associated shear wave velocity measurements between 35 healthy volunteers and 25 subjects undergoing surgical repair for ventral hernia. Subjects with ventral hernia will undergo imaging no earlier than two weeks prior to elective hernia repair and again postoperatively within six months following repair at a standard followup visit. Statistical analysis will determine if there is a significant difference in the abdominal wall stiffness, represented by the ultrasound shear wave velocity measurements, between the healthy subjects and the subjects with ventral hernia. Further analysis will determine if there is any statistically significant relationship between abdominal wall stiffness of subjects with ventral hernia and surgical outcomes.
The invention discloses aspirin pulsed release pellets, its preparation and a preparation method thereof. The pellets comprise blank pellets, an aspirin-containing drug layer, an isolation layer, a regulation releasing layer and a protective layer. The regulation releasing layer contains polyprotic acid and/or its salt, anionic polymer salt, a plasticizer and an antiadherent. The anionic polymer salt is prepared by the following method: dissolving an enteric material, and using alkali to neutralize to a pH value greater than the enteric material dissolution pH value 0.1-3. The protective layer contains the enteric material, the plasticizer and the antiadherent. The enteric material is any one material selected from: an enteric material dissolved at pH value of 4.5-5.5 to prepare pellets I; an enteric material dissolved at pH value of 6.0-6.5 to prepare pellets II; or an enteric material dissolved at pH value of 7.0-8.0 to prepare pellets III. According to the preparation, local drug concentration will not be high, accumulation of the drug inside the body can be reduced, patient compliance can be improved, and stability inside the body can be raised. Therefore, bioavailability and the antithrombotic effect are raised.
Vancomycin Hydrochloride for Injection, USP is a lyophilized powder, for preparing intravenous (IV) infusions, in vials each containing the equivalent of 1 g vancomycin base. 500 mg of the base are equivalent to 0.34 mmol. When reconstituted with Sterile Water for Injection to a concentration of 50 mg/mL, the pH of the solution is between 2.5 and 4.5. Vancomycin Hydrochloride for Injection, USP should be administered intravenously in diluted solution (see DOSAGE AND ADMINISTRATION). FURTHER DILUTION IS REQUIRED BEFORE USE.

Vancomycin is a tricyclic glycopeptide antibiotic derived from Amycolatopasis orientalis (formerly Nocardia orientalis). Vancomycin hydrochloride has the following structural formula: 

  


C 66H 75Cl 2N 9O 24• HCl M.W. 1485.73
INTRODUCTION: The treatment of chronic postdissection aneurysms of the aortic arch is a challenge. This study aims to describe false lumen management after aortic arch endovascular repair of post-type A dissection aneurysms treated with a branched endograft.
METHODS: In this single-center retrospective observational study, all consecutive patients undergoing endovascular treatment of aneurysmal degeneration of chronic type A aortic dissections following open repair were enrolled. The primary endpoint was maximal aortic diameter evolution measured on computed tomography angiography (CTA) performed during follow-up. Secondary endpoints included procedural success, aortic re intervention, and remodeling during follow-up.
RESULTS: Between January 2017 and June 2020, 22 patients underwent endovascular branched arch repair for post type A dissection aneurysms. Technical success was 100%. Thirteen patients (59%) had dissection involvement of at least 1 supra-aortic vessel. Midterm follow-up CTA was performed for 20 patients, 23.1 (±13.3) months after the procedure. Maximal aortic diameter at the level of the repair was decreasing in 13 (65%) patients, increasing in 2 (10%) patients, and no change was observed in 5 (25%) patients. During follow-up, 7 patients (35%) required aortic reintervention. Thoracic candy plugs were implanted for distal false lumen occlusion in 15 patients and associated with a high rate of complete remodeling (6/15 patients, 40%).
CONCLUSION: Arch branch endografting of aneurysmal evolution of a post type A dissection aortic arch is a safe and feasible option in experienced hands. Candy plug use in favorable anatomies seems to be associated with accelerated remodeling of the aorta.
CLINICAL IMPACT: There are currently no recommendations on dissected supra- aortic vessels management and the use of thoracic aorta false lumen occlusion devices during endovascular repair of chronic post dissection aneurysm of the aortic arch with branched endografts. Based on our clinical experience reported in the current manuscript, we propose a treatment algorithm for the management of the false lumen in this setting.
PURPOSE:A cosmetic having good feeling in use, improved shelf stability free from skin irritation, containing an oil obtained from seed of Oenothera tetrapera Cav. and at least one extract prepared from seed of Helianthus annuus L., root of Bupleurum falcatum L., and rhizome of Sanguisorba officinalis L. CONSTITUTION:(A) An oil obtained from seed of Oenothera tetraptera Cav. is blended with (B) at least one extract obtained from seed of Helianthus annuus L., Bupleurum falcatum L., and rhizome of Sanguisorba officinalis to give a cosmetic. A skin cosmetic containing an oil of Oenothera tetraptera Cav. has higher affinity for the skin than one containing an olive oil, almond oil, safflower oil, etc., has no greasiness on the skin, and provides a feeling of moisture. It is a vegetable oil with high unsaturation degree, so addition of the component B as a shelf stabilizer provides the cosmetic with stability for a long period.
Carcinogenesis: In carcinogenicity studies in mouse and rat, sumatriptan was administered orally for 78 weeks and 104 weeks, respectively, at doses up to 160 mg/kg/day (the high dose in rat was reduced from 360 mg/kg/day during Week 21). The highest dose to mice and rats was approximately 130 and 260 times the single MRHD of 6 mg administered subcutaneously on a mg/m2 basis. There was no evidence in either species of an increase in tumors related to sumatriptan administration. 

Mutagenesis: Sumatriptan was negative in in vitro (bacterial reverse mutation [Ames], gene cell mutation in Chinese hamster V79/HGPRT, chromosomal aberration in human lymphocytes) and in vivo (rat micronucleus) assays. 

Impairment of Fertility: When sumatriptan (5, 50, 500 mg/kg/day) was administered orally to male and female rats prior to and throughout the mating period, there was a treatment-related decrease in fertility secondary to a decrease in mating in animals treated with doses greater than 5 mg/kg/day. It is not clear whether this finding was due to an effect on males or females or both. When sumatriptan was administered by subcutaneous injection to male and female rats prior to and throughout the mating period, there was no evidence of impaired fertility at doses up to 60 mg/kg/day.
The invention relates to a herbal polypharmaceutical for treating and preventing atherosclerosis, comprising tannins, phenols, flavonoids, sugars, coumarins, terpenes, which has an anti-inflammatory and immunomodulating function. In addition, the invention regenerates the endothelium and provokes the reversal of the endothelial dysfunction, and the degradation of the atheromatous plaque. The polypharmaceutical increases the synthesis of nitric oxide at an endothelial cell level, relaxing the muscular wall of the arteries and provoking vasodilatation, also some of the components thereof inhibit the platelet aggregation and reverse the prothrombotic condition. The agents preset in the product may hydrolyze the calcified complex of LDL-OX and contribute to the disintegration of foamy cells, thus favouring the elimination thereof as well as the regeneration of the vascular endothelium and sub-endothelium, and the recovery of the arterial lumen calliper. The product also presents an antipl atelet activity which prevents thrombus from forming, the compounds included in the product may hydrolyze the atheromatous plaques. The herbal polypharmaceutical is made of root and rhizome of Gentiana lutea and a Hippocratea excelsa alcohol extract. The invention has been probed for a long term, as a preventive and as a cure, in a large amount of patients with positive results, without side effects.
The invention relates to a traditional Chinese medicine composition for preventing and treating swine enzootic pneumonia. The traditional Chinese medicine composition is prepared from cassia twig, Chinese herbaceous peony, liquorice, ginger, Chinese-dates, mangnolia officinalis, almonds, ephedra, gypsum, platycodon grandiflorum and trichosanthes kirilowii maxim. The traditional Chinese medicine composition can be an oral liquid. The preparation method comprises the following steps: (1) crushing the traditional Chinese medicines to particles of 30-80 meshes, weighing according to a formula amount and three-dimensionally mixing to obtain traditional Chinese medicine powder; (2) inputting the mixed traditional Chinese medicine powder into an extraction tank, adding 5-15 times of water and decocting for 2-12 hours; (3) filtering to remove residues, wherein the obtained filtrate is reserved for later use; (4) inputting the residues into the extraction tank again, adding 5-10 times of water and decocting for 2-12 hours; (5) filtering to remove residues, and combining the obtained liquid and a first extraction liquid; and (6) decompressing and concentrating to 10-50% of original volume at 30-100 DEG C, filtering to remove residues and filling, 250ml per bottle. The traditional Chinese medicine composition provided by the invention can be used for effectively preventing and treating swine enzootic pneumonia with the cure rate being over 90%. The traditional Chinese medicine composition has the functions of inducing sweat and dispelling exogenous evils, freeing lung and relieving asthma, eliminating phlegm by cooling and relieving cough.
Behçet's disease is a systemic vasculitis of unknown origin. It mainly affects young men. Vascular involvement mainly affects the veins and may manifest as deep or superficial thrombosis. Arterial involvement is rare and serious. Arterial thrombosis or aneurysms/false aneurysms can be life threatening in case of rupture. All the arteries in the body can be affected, with widely varying frequencies. Involvement of the renal arteries is very rare. We report the case of a young patient followed for schizophrenia and known to have Behçet's disease, in whom a false aneurysm of the right renal artery was diagnosed during hematuria. He unfortunately refused any type of intervention.
It is the hypothesis that cancerous lesions in the prostate will have an increased amount of blood flow, and that the lesions identified under ultrasound with the benefits of contrast-enhanced imaging can be correlated to the MRI Findings in real-time. A study of 50 patients who would be undergoing MRI/Ultrasound fusion would be selected to have contrast added to their procedure. The lesions identified on MRI would then be evaluated with contrast-enhanced ultrasound. The findings from the contrast study could then be correlated with the MRI findings. The rest of the prostate gland would also be assessed using the contrast agent for lesions not identified on the MRI imaging study. The pathology results could be correlated with both the contrast study and the MRI study both independently, and in conjunction with the two imaging modalities. If a correlation between highly suspicious lesions on the MRI and significant flow patterns under contrast can be established, then the sensitivity and specificity of contrast-enhanced ultrasound can be increased.

While MRI / Ultrasound Fusion is being shown to increase prostate cancer identification and targeting for biopsy, it is a very limited modality due to the costs associated. Many sites will also not have access to an MRI unit, and the fusion system is prohibitively expensive, and requires specialized training to configure the system and modulate the images in real-time. However, ultrasound is an in expensive modality that is readily available. If the materials and methods in the utilization of contrast-enhanced ultrasounds can be correlated to MRI / Ultrasound fusion, better protocols can be developed for contrast-enhanced ultrasound. This more cost-effective method of identifying and targeting prostate cancer could then be exported to smaller communities who would otherwise still be carrying out the sextant biopsy model.
Subjects will be given 2 g/day placebo (rice flour). Salivary estrogen will be measured around ovulation and menstruation each month for 3 months. Knee laxity will be measures 2 times per month at the same time points as the intervention arm (ovulation, menstruation).
This is a single center double blinded randomized controlled study comparing the effectiveness of epsilon-aminocaproic acid (EACA) and tranexamic acid (TA) in reducing 24hour blood transfusion and chest tube drainage. From October 2008 to September 2011, patients greater than 18 years of age, scheduled for cardiac surgery requiring CPB were consented. Eligible operations included; coronary artery bypass graft surgery (CABG), a heart valve repair/replacement, or a concomitant CABG and valve surgery were enrolled.

Consented patients were randomized into one of the two groups using a 1:1 randomization sequence generated by a computer program. Randomization sequence and the study drugs were kept in a locked box and were opened only by unblinded study personnel who were not involved in the clinical care of the patient. This person prepared the study drug following the instructions of the study protocol, resulting in preparations of EACA and TA that contained equi-potent similar volumes of the drug in the syringe, in order to ensure blinding. Antifibrinolytic study drug was administered following anesthetic induction. EACA was administered as a bolus loading dose of 150 mg/ kg followed by a maintenance infusion of 15 mg/ kg /hr. TA was administered as a bolus dose of 30 mg /kg followed by a 16 mg/ kg/hour maintenance infusion. Maintenance infusion of both drugs was discontinued when the patient arrived in the cardiac surgical intensive care unit. In addition to routine blood sampling ( standard of care in the investigators hospital), patients had thromboelastogram(TEG) and D-dimer levels drawn at the following time points: post incision but prior to initial antifibrinolytic load, immediately following the antifibrinolytic loading dose, and post-protamine reversal of heparin.

The primary endpoint was the amount of chest tube drainage and the amount of blood products used in the first 24 hours following surgery (surrogate measurement for blood loss) was measured at 4, 8, 12 and 24 hours after surgery. The incidence of packed red blood cells (PRBC), fresh frozen plasma (FFP), cryoprecipitate and platelets administered during the first 24 hours after surgery was collected. Additionally, patients were monitored for any complications during their stay in the hospital and up to 30 days post-operatively. Complications included renal dysfunction (defined as the need for at least 1 hemodialysis or doubling of pre-surgical creatinine levels), stroke and seizures (clinically diagnosed), myocardial infarction (new Q waves in two electrocardiogram leads), cardiac arrest, respiratory failure, re-operation and death. Monitoring of the patients prior to discharge involved chart review during their stay in the hospital; if a post-operative complication was suspected, the complication was confirmed using Montefiore Medical Center's Carecast Database, which contained independent results such as MRI's, CT scans, or labs. Additionally, computer records of the patients were searched to determine if there were documented complications in the 30-day post-operative time period.
In transsphenoidal surgery (TSS) for pituitary adenoma (PA), gross total resection (GTR) is often the target since it has been shown to relevantly influence long term patient outcome. This applies both to functioning adenomas (FA) as well as to non-functioning adenomas (NFPA). Mounting evidence shows that in cases where GTR is not achievable, maximizing extent of resection (EOR) is still highly desirable, particularly in case of FA, with the aim of obtaining the smallest possible residual volume (RV).

Predictive analytics for GTR, EOR and RV are useful in surgical decision-making, particularly whenever there is no unequivocal indication for surgery. Several factors have been shown to have a role in predicting GTR. Among these, the Knosp classification has proven over the years to be a good predictor of GTR. The score is based on the lateral extension of the adenoma in relation the the intracranial bedding of the internal carotid artery. However, recent literature has demonstrated that the Knosp classification suffers from relatively poor interrater agreement. Moreover the classification was conceived in an era when endoscopic techniques were not available: nowadays endoscopic technique allows visualization and possibly also reaching portions of adenoma which at the time when the Knosp classification was introduced were simply not possible. Lastly, the efficacy of the Knosp's score in predicting also EOR and RV has never been tested.

Recently a new score - the Zurich Pituitary Score (ZPS) has been proposed at the University Hospital of Zürich (USZ). The score has proved in the examined series to be more powerful than the Knosp classification in predicting GTR, EOR and RV. A good interrater agreement was also demonstrated. The score however, has been validated only in a monocentric setting with a limited number of patients. The aim of this study is to assess the (1) predictive ability of the ZPS for GTR, EOR, and RV, and (2) the inter-rater agreement of the ZPS in an external validation study.