anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Background and Objectives: Attentional bias (AB) for addictive substances is a feature of attention found in individuals with substance misuse or diagnosed with substance use disorders. When AB exists, the attention of the addicted individual may be quickly oriented to cues related to the addictive substance or be maintained on these cues for a longer time. AB toward opioids was found in Western samples of smokers with chronic noncancer pain. The level of AB was dose-responsive. However, similar studies in the Taiwanese population are lacking. This study compared the patterns of AB for opioid analgesics in Taiwanese participants with chronic noncancer pain to that of individuals without pain. This study aimed to investigate if AB toward opioids is presented in Taiwanese heavy smokers who are on long-term opioid therapy for pain control. Materials and Methods: Participants were grouped into chronic noncancer pain smokers, chronic pain nonsmokers, and smokers without pain, according to smoking habits and whether or not on long-term opioid therapy for pain control. Each participant completed demographic questionnaires, mood scales, and the opioid-related visual probe task. Differences in AB among the groups were compared using a three-way analysis of covariance controlling for daily cigarette consumption. Results: Chronic noncancer pain smokers (n = 17) and chronic pain nonsmokers (n = 16) displayed more severe levels of depression, anxiety, and pain, compared to smokers without pain (n = 28). Only did chronic pain nonsmokers show significant AB for opioid cues that were displayed for a short time. Analysis on reaction time found that smokers without pain consistently responded faster to the tasks. No difference in reaction time was found between the pain groups. Conclusions: The current study did not fully replicate findings from studies that were based in Western countries. Formulary availability and regulatory limitations might have affected patient's perception of prescription opioids in Taiwan. However, chronic pain nonsmokers exhibited initial orientation toward opioid-related cues when daily cigarette consumption was accounted for. According to previous research, this AB for shortly displayed opioid cues can be associated with the expectation of pain relief. The current finding also indicated general psychomotor retardation in individuals who were on long-term use of opioids.
Post-joint arthroplasty infections, especially surgical site infections (SSI) and periprosthetic joint infections (PJI), significantly impact patient outcomes. The potential influence of malnutrition on these postoperative complications remains a crucial concern for clinicians. Adhering to PRISMA guidelines, we performed a systematic review and meta-analysis using four databases up to 19 July 2023. We sought studies on joint replacements, focusing on malnutrition as an SSI risk factor. The malnutrition criteria were defined by specific laboratory parameters. Two independent reviewers undertook data extraction and quality assessment, with discrepancies resolved through consensus or third-party review. Studies were evaluated for methodological quality using the Newcastle-Ottawa Scale (NOS). For statistical analyses, heterogeneity was assessed using the I2 statistic, and both fixed and random-effects models were employed based on heterogeneity levels, utilizing Stata software (version 17). Significant heterogeneity was present among studies examining the relationship between malnutrition and SSI (I2 = 59.5%, p = 0.03%). Employing the random-effects model, results indicated that malnourished individuals were approximately 2.63 times more likely to develop SSI post-operation. Further exploration into the association between malnutrition and PJI, from seven pertinent studies, also revealed an elevated risk (OR = 2.59, 95% CI: 1.79-3.39). Sensitivity analyses confirmed the robustness of these findings, and publication bias assessments supported the validity of the included studies. Malnutrition robustly correlates with an increased risk of both SSI and PJI following total joint arthroplasty. Emphasizing preoperative nutritional assessments and intervention strategies may offer a promising avenue to enhance patient outcomes and reduce postoperative complications.
Patients between the ages of 18-65, who will undergo laparoscopic gynecological surgery, American Society of Anesthesiologists (ASA) class I-II-III, Body Mass Index (BMI) in the range of 18-25 kg/m², and who will use 3 or 4 trocar for surgery will be included in the study. Patients will be randomized into two groups. OSTAP block will be performed for OSTAPB group and TQL block will be performed for TQLB group. Patients will be administered postoperative 4x500 mg iv paracetamol as needed (if Visual Analogue Scale (VAS) score is 4 or higher). If the VAS score remains at 4 or higher 30 minutes after paracetamol administration, 1 mg/kg iv tramadol will be administered as a rescue analgesic (with a daily maximum dose of 400 mg). The primary outcome is to compare the total analgesic consumption within the first 24 hours after surgery. The secondary outcome is to compare the time to the first postoperative analgesic requirement, VAS scores at rest and on movement, and assess the impact of these two blocks on the quality of recovery using the QOR-15 scale
Interested patients will attend a group meeting where they will be screened and consented to the study. During weeks 1 and 2 patients will complete pre-intervention baseline assessments and blood draws followed by a 16-week supervised exercise program at Get REEL and HEAL facility. Study participants will complete progressive aerobic and resistance exercise training. Post-intervention weeks 1 and 2 participants will complete assessments, questionnaires and blood draws. Participants will be followed up at 6 and 12 months post intervention with physical assessments, questionnaires and blood draws. Annual follow-up will occur at year 2,3,4 and 5 post intervention with questionnaires only.
Ultrasound image devices, systems and methods are provided. A system is configured to determine and track manipulation of an ultrasound probe during an ultrasound exam. Tracked probe manipulations may be synced with recorded user inputs received by the system during the exam. Probe manipulations paired with user inputs are stored as comprehensive log files documenting the exam, which are then converted into narrative text summaries for user review. A neural network is implemented to determine probe positions and orientations utilized during the exam based on landmarks identified in acquired image frames. User inputs received by the system are filtered such that only inputs indicative of exam performance are paired with the determined manipulations of the probe. External sensors are not necessary to track probe motion, but may be implemented to augment or replace certain system features.
The invention relates generally to antimicrobial compositions that are non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The antimicrobial compositions contain at least one zinc compound that is microbicidal to at least one microorganism. The antimicrobial compositions of the invention can be diluted in suitable proportions into suitable solvents to produce the desired dosages for each individual application. The antimicrobial compositions can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like. The compositions can also be used as preservatives. The antimicrobial compositions can also be made as gels or solids in different forms by using techniques available to those skilled in the art.
A generic 'Integrated Theory-based Framework for Implementation Tailoring Strategies' toolkit (the ItFits-toolkit) functions as an online self-help toolkit by which users are guided through the process of tailoring site-specific implementation strategies. The ItFits-toolkit includes four modules that implementers need to work through: 1) identifying and prioritising implementation goals and determinants of practices, 2) matching up implementation determinants to strategies, 3) designing a plan for carrying out strategies in a local context, and 4) applying strategies, and reviewing progress. In each of these four modules, evidence-informed materials such as iCBT relevant determinants of practices and implementation strategies, are included as well as methods for engaging with stakeholders.
A method of enabling a healthcare clinic to provide IMRT services on an outsourced basis comprises initially determining the existing capabilities of the clinic to deliver IMRT services. An implementation plan is developed based on the determining step. The implementation plan is designed to enable the clinic to achieve at least a baseline competence in delivering IMRT services. The implementation of the plan may include providing equipment, validating a communication link, providing policies and procedures for services to be rendered, and establishing a QA program for the services to be rendered. The clinic's staff is trained and tested. Thereafter, the readiness of the clinic to deliver IMRT services is evaluated based on the testing.
A system and method for managing access to a plurality of carts. A plurality of users may be created in a database, each user having unique identifying information. Users may be grouped into user groups when having similar attributes. Each cart may have an entry in the database with associated attributes. Carts may be grouped into cart groups for carts having similar attributes. Users may be given access to cart either individually, through a user group that has access to the cart, by given access to an entire group of carts, or through a user group that has access to an entire group of carts. The various associations can be interwoven to provide groups and sub-groups for managing applications where multiple users must interact with multiple carts. The carts can store access logs which may be communicated in real time to a computing device or may be stored locally at the cart for later access by an administrator.
OBJECTIVE: Musculoskeletal (MSK) causes of chest pain are considered common in emergency care, yet management is limited, reported outcomes are poor and prevalence data in New Zealand are lacking. The present study aims to estimate the prevalence of MSK chest pain in New Zealand EDs and describe the characteristics of MSK chest pain cases.
METHODS: A retrospective chart review was conducted based on de-identified clinical notes extracted from four hospitals within the South Island of New Zealand from 3 months spanning 1 March to 31 May 2021. Individual cases were categorised to the single best-fitting cause of chest pain using systems-based categorisation, based primarily on the doctors' documented final impression.
RESULTS: A total of 1344 cases were categorised in the present study. MSK chest pain had a prevalence of 15% (range 11-31%) of chest pain presentations across all study sites. This represented the second most common system responsible for chest pain, after the cardiovascular system. The mean age of MSK chest pain cases was 46.9 (standard deviation [SD] 19.1) years, compared to 55.5 (SD 19.7) years in all cases. Age and gender-specific data, data from rural hospitals and MSK sub-type data are presented.
CONCLUSIONS: These data provide a conservative estimate of MSK chest pain prevalence in EDs within the South Island of New Zealand. The findings highlight MSK chest pain as common in emergency care, providing a basis and justification for further research to improve management and outcomes for people with MSK chest pain.
PROBLEM TO BE SOLVED: To obtain the subject composition usable very easily, free from any problem from a Be-Kind-to-Animal point of view as well, having great effect, and also having no harmful effect on pets such as side effects by including a specific amino acid. SOLUTION: This composition is obtained by including (A) theanine and, pref. furthermore, (B) at least one compound selected from the group of compounds consisting of highly unsaturated fatty acids and choline, wherein the ingredient A is pref. the L-modification of theanine, and may be in any form, refined product, crudely refined product, extract, or the like; and the highly unsaturated fatty acid is pref. arachidonic acid or docosahexaenoic acid. The dose of this composition to a pet is pref. 0.05-100 mg/kg body weight when to be used as the ingredient A singly, or being pref. 0.02-20 mg/kg as the ingredient A and 0.2-80 mg/kg as the ingredient B when to be administered as the composition comprising the ingredients A and B.
Participants received a single dose of JE-CV administered in Study JEC02. In Study JEC05 there were yearly visits with blood samples taken for immunogenicity assessment.
Brain dynamics is highly non-stationary, permanently subject to ever-changing external conditions and continuously monitoring and adjusting internal control mechanisms. Finding stationary structures in this system, as has been done recently, is therefore of great importance for understanding fundamental dynamic trade relationships. Here we analyse electroencephalographic recordings (EEG) of 13 subjects with unresponsive wakefulness syndrome (UWS) during rest and while being influenced by different acoustic stimuli. We compare the results with a control group under the same experimental conditions and with clinically healthy subjects during overnight sleep. The main objective of this study is to investigate whether a stationary correlation pattern is also present in the UWS group, and if so, to what extent this structure resembles the one found in healthy subjects. Furthermore, we extract transient dynamical features via specific deviations from the stationary interrelation pattern. We find that (i) the UWS group is more heterogeneous than the two groups of healthy subjects, (ii) also the EEGs of the UWS group contain a stationary cross-correlation pattern, although it is less pronounced and shows less similarity to that found for healthy subjects and (iii) deviations from the stationary pattern are notably larger for the UWS than for the two groups of healthy subjects. The results suggest that the nervous system of subjects with UWS receive external stimuli but show an overreaching reaction to them, which may disturb opportune information processing.
Degenerative arthritis is a common disease in the elderly , in recent years, there are young trends, the symptoms often cause great pain in the elderly, associated with lower physical exercise caused by decreased muscle mass, functional fitness performance Is also poor, affecting the ability of elderly people to live independently. Therefore, this study mainly explores whether the intervention of tai chi can improve the functional fitness of the elderly and reduce the pain index of the elderly. The study was designed to take the sample, which was divided into experimental group and control group. It was expected to receive 100 people. The subjects were asked to use the basic information, Karnofsky scale, The functional fitness test, the exercise conscious scale and the WOMAC pain scale were used as the research tools. The SPSS system was used to analyze whether the functional fitness index and the pain index were significantly different before and after exercise intervention. Whether the exercise intervention has an effect on the elderly.
An effort target value of life style more suitable for the user is calculated while correcting the influence of the answer tendency of the user. In a health care assisting device (600), a target value recording section (602) receives an input of a target value of bioinformation of the user on an effort term about the life-style at the start of a predetermined period. A measured value input section (603) receives an input of a measured value of the bioinformation of the user after the period. An answer sheet input section (604) receives an input of the answer value which is a self evaluation value of the user of the achievement degree of the target value of the effort term about the life style after the period. A corrected target value generating unit compares the measured value of the bioinformation inputted after the period with the target value of the bioinformation inputted at the start of the period and corrects the inputted answer value according to the result of the comparison. A target value updating section (611) determines the target value of the effort term about the life style to be performed for the next period according to the corrected answer value.
Determining the genetic contribution of susceptibility to severe SARS-CoV-2 infection outcomes is important for public health measures and individualized treatment. Through intense research on this topic, several hundred genes have been implicated as possibly contributing to the severe infection phenotype(s); however, the findings are complex and appear to be population-dependent. We aimed to determine the contribution of human rare genetic variants associated with a severe outcome of SARS-CoV-2 infections and their burden in the Slovenian population. A panel of 517 genes associated with severe SARS-CoV-2 infection were obtained by combining an extensive review of the literature, target genes identified by the COVID-19 Host Genetic Initiative, and the curated Research COVID-19 associated genes from PanelApp, England Genomics. Whole genome sequencing was performed using PCR-free WGS on DNA from 60 patients hospitalized due to severe COVID-19 disease, and the identified rare genomic variants were analyzed and classified according to the ACMG criteria. Background prevalence in the general Slovenian population was determined by comparison with sequencing data from 8025 individuals included in the Slovenian genomic database (SGDB). Results show that several rare pathogenic/likely pathogenic genomic variants in genes CFTR, MASP2, MEFV, TNFRSF13B, and RNASEL likely contribute to the severe infection outcomes in our patient cohort. These results represent an insight into the Slovenian genomic diversity associated with a severe COVID-19 outcome.
OBJECTIVE: First bite syndrome (FBS) is a rare complication of transoral surgery (TOS) for oropharyngeal cancer (oropharyngeal squamous cell carcinoma [OPSCC]). Risk factors for developing this complication are not well described. In this study, we attempt to identify risks for developing FBS in TOS.
STUDY DESIGN: Retrospective chart review.
SETTING: Tertiary care medical center.
METHODS: This study was exempted by the Mayo Clinic institutional review board. We performed a review from January 2017 to November 2022 of all patients who underwent TOS for OPSCC by a single provider. Exclusion criteria included less than 6 months follow up, prior treatment of head and neck cancer, or incomplete records. Demographic data, comorbidities, tumor characteristics, surgical details, adjuvant treatment details, functional outcomes, and oncologic outcomes were assessed. Fisher's Exact test and Kruskal-Wallis rank sum test were used to identify significant variables, and multivariable logistic regression was used to address confounding.
RESULTS: One hundred and one patients were identified. Eighty-nine met the inclusion criteria. The mean follow-up was 34 months (median 33). Seven patients (7.9%) developed FBS. Palatine tumor primary (P = .041), resection of styloglossus/stylopharyngeus (P = .039), and parapharyngeal fat manipulation (P = .015) were associated with the presence of FBS. After adjusting for tumor location, manipulation of parapharyngeal fat maintained significance (P = .025). T and N staging, tumor volume, adjuvant radiation, and ligation of lingual/facial arteries were not associated with the development of FBS. Eighty-six percent (6/7) of patients had a resolution of FBS at an average of 11.3 months.
CONCLUSION: Manipulation of the parapharyngeal space is independently associated with developing FBS in TOS in our cohort. Further confirmatory studies are warranted.
This paper presents a systematic investigation into the effectiveness of Self-Supervised Learning (SSL) methods for Electrocardiogram (ECG) arrhythmia detection. We begin by conducting a novel analysis of the data distributions on three popular ECG-based arrhythmia datasets: PTB-XL, Chapman, and Ribeiro. To the best of our knowledge, our study is the first to quantitatively explore and characterize these distributions in the area. We then perform a comprehensive set of experiments using different augmentations and parameters to evaluate the effectiveness of various SSL methods, namely SimCRL, BYOL, and SwAV, for ECG representation learning, where we observe the best performance achieved by SwAV. Furthermore, our analysis shows that SSL methods achieve highly competitive results to those achieved by supervised state-of-the-art methods. To further assess the performance of these methods on both In-Distribution (ID) and Out-of-Distribution (OOD) ECG data, we conduct cross-dataset training and testing experiments. Our comprehensive experiments show almost identical results when comparing ID and OOD schemes, indicating that SSL techniques can learn highly effective representations that generalize well across different OOD datasets. This finding can have major implications for ECG-based arrhythmia detection. Lastly, to further analyze our results, we perform detailed per-disease studies on the performance of the SSL methods on the three datasets.
Although there were no obvious hematologic abnormalities observed in treated patients in the levetiracetam extended-release tablet controlled study, the limited number of patients makes any conclusion tentative. The data from the partial seizure patients in the immediate-release levetiracetam tablet controlled studies should be considered to be relevant for levetiracetam extended-release tablet-treated patients. 

In controlled trials of immediate-release levetiracetam tablets in patients experiencing partial onset seizures, minor, but statistically significant, decreases compared to placebo in total mean RBC count (0.03 x 106/mm3), mean hemoglobin (0.09 g/dL), and mean hematocrit (0.38%), were seen in immediate-release levetiracetam tablet-treated patients. A total of 3.2% of treated and 1.8% of placebo patients had at least one possibly significant (≤ 2.8 x 109/L) decreased WBC, and 2.4% of treated and 1.4% of placebo patients had at least one possibly significant (≤ 1.0 x 109/L) decreased neutrophil count. Of the treated patients with a low neutrophil count, all but one rose towards or to baseline with continued treatment. No patient was discontinued secondary to low neutrophil counts.
The present invention relates to genetic engineering. A blue algae gene expression system which comprises a groESL strong promoter region of a blue algae heat shock gene, a UBT alpha1 region and an rbcS terminal region of a target gene, and a Km marker gene and completely and efficiently expresses is constructed. Moreover, thymosin alpha1 is expressed by using a gene integration platform system and a shuttle plasmid system in a transgenic way. The blue algae gene expression system is easily controlled because of using a groESL strong promoter of the heat shock gene, and the transcription is rapidly carried out in hundreds of times by the thermal induction. Simultaneously, the target gene T alpha1 is efficiently expressed by using the ubiquitin fusion technology. The present invention has simple technology, and a user draws inferences about other cases from the instance. Thus, the present invention has considerable development prospect, and furthermore, the present invention opens up a new path for developing the transgenic blue algae in an industrialized way.