anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
AIM: To describe patients' with chronic obstructive pulmonary disease (COPD) experiences of group-based self-management education with a digital website.
DESIGN: A qualitative approach with a phenomenologicalmethod. Patients participating in an earlier study, with self-experience of COPD as a special competence, were involved as research partners at the design of this study.
METHODS: Eleven individual and two group interviews with five participants in each group were conducted.
RESULTS: Group-based self-management education with a digital website supports learning. Sharing experiences with others in similar situations creates security and reduces the feeling of being alone. Based on questions and discussion in the group, and through self-reflection, general information is transformed into useful knowledge and understanding of one's own situation. COPD information on the website provides an opportunity to gain knowledge continuously based on needs that contributes to learning. This research has demonstrated that adapting learning activities to individual learning styles increases sustainability of learning. Sharing experiences reduces feelings of loneliness. It is therefore important to create spaces for sharing experiences and in-depth reflection that support learning over time.
The present invention provides a Chinese herbal medicine application for treating fractures, which is a powdery mixed composition made from the components of portions by weight: 1 portion of oleanderleaf agapetes root, 0.15 to 0.25 portion of falcate dolichos root or leaf, 0.25 to 0.4 portion of Helwingia chinensis Batal, 0.4 ot 0.7 portion of Lancang saurauia bark and 0.005 to 0.008 portion of gelsemium elegans. When used, the evenly mixed powder is prepared into paste by wine or boiled water, and the paste is applied to the fracture site. Meanwhile, kusnezoff monkshood root, lindenleaf torricellia bark or leaf, crisped tinospora stem, monkshoodvine root-bark, tuberculate speranskia herb, potts waxplant leaf, scandent schefflera root, adnate elder herb, eucommia bark, false nettleleaf pepper herb, etc. can also be added to the Chinese herbal medicine application for treating fractures. The present invention is used for treating fractures with obvious bonesetting effect, and the required rehabilitation time is less than 50% of that of western medicine. When the Chinese herbal medicine application for treating fractures is matched with steel-nail steel-plate bonesetting correcting operation, gypsum sleeves, and even clamping plates can be cancelled so as to relieve patients' pain and inconvenience, avoid generation of side effect and greatly save medical cost.
Patients will be enrolled in the study at George Washington University Hospital's Emergency Department. Patients who consent will be randomly assigned to one of two groups; (1) standard Written Discharge Instructions from the nursing staff (2) standard Written Discharge Instructions from the nursing staff AND watching the Video Discharge Instructions on a tablet. Subjects will complete a survey after they have received their discharge instructions and before leaving the ER. Several (5-7) days after leaving the Emergency Department, subjects will receive a phone call from one of the investigators staff members asking 2-3 questions about their ED visit and how they treated the condition at home. The survey questions at discharge and at follow-up will pertain to how to care for the condition and will be based on the discharge instructions. The study is designed to determine if patients retain health information more accurately if they watch a video in addition to being given written information. A total sample size of 200 participants will be recruited. Enrollment for this study will begin June of 2016 and will continue until the investigators have enough participants. The data analyst will be blinded to treatment assignment when analyzing the data.
FIELD: medicine, veterinary. ^ SUBSTANCE: group of inventions relates to veterinary. Parasiticidal water suspension, including from 5 to 60 wt % of mixture, which includes from 60 to 99 wt % of alkali metal bicarbonate and from 1 to 40 wt % of silicon dioxide particles, silicon dioxide particles having average size less than 10 mcm, and, when said bicarbonate is represented by sodium bicarbonate, suspension includes said sodium bicarbonate in amount of less than 20 wt % of total suspension weight. Method of struggle with development of parasites on animals, kept indoors, in accordance to which environment surrounding animals in premises is brought into contact with said water suspension. Application of said water suspension of combined parasiticidal and antifungal action. ^ EFFECT: group of inventions ensures long-lasting efficiency of claimed parasiticidal water suspension on farm animals, which is safe for people and has a low cost. ^ 3 cl, 6 ex
The present invention provides an application of epalrestat in preparation of a pancreatic cancer drug, and the pancreatic cancer drug is applied to inhibiting exosome secretion of a pancreatic cancer cell. A pharmaceutical composition for resisting pancreatic cancer contains epalrestat. The pharmaceutical composition is applied to inhibiting exosome secretion of the pancreatic cancer cell. Embodiments of the present invention further provide a method for verifying the inhibition effect of epalrestat on exosome secretion of the pancreatic cancer cell, comprising the following process: extracting a cell supernatant exosome by using a low-temperature ultracentrifugation method; quantifying protein by using a BCA kit after lysing the collected exosome, and reflecting the amount of the exosomes by using the measured amount of the protein; verifying a double-layer lipid membrane wrapped cup-shaped structure of the exosome by using a transmission electron microscope; and detecting exosome protein concentration by means of protein polyacrylamide gel electrophoresis having Coomassie brilliant blue. The present invention provides new use of epalrestat, i.e., the inhibition of exosome secretion. The epalrestat has great application potential in clinical tumor treatment.
All pregnant patients with one or more fetuses suffering from a microretrognathia, diagnosed prenatally and integrated into a Pierre Robin Sequence, were included. All cases were confirmed postnatally, either by a pediatric examination or by a fetopathological examination in the case of a medical termination of the pregnancy. We had 21 cases.
There is no consensus on whether cardiac troponins with high reliability values should be different diagnostic criteria for acute myocardial infarction in patients with and without renal dysfunction. Although it is often emphasized that the etiology of elevated troponin levels in chronic kidney disease (CKD) remains unclear, elevated cardiac troponin (cTnT) levels have been associated with increased subclinical cardiac damage in these patient groups. In this study, we investigated the value of cTnT value in diagnosing acute coronary syndrome in CKD patients with high clinical suspicion of acute coronary syndrome and without acute ST segment elevation on electrocardiogram. The aim was to prevent cardiac ischemia from being overlooked in CKD patients. Coronary angiography revealed vessel occlusion in 192 patients, and the mortality rate after treatment decisions was 6.7%. The first measured troponin results showed a significant difference in patients who did not survive, indicating the prognostic value of troponin levels. Troponin values were compared with cardiovascular pathologies obtained by angiography, and elevated troponin levels strongly correlated with pathologic angiography results. The conclusion highlighted that despite prognostic uncertainties, biomarkers used for acute myocardial infarction diagnosis in patients with renal insufficiency are reliable in those with renal dysfunction. Elevated cTnT levels in CKD patients are considered a clear marker of cardiac ischemia, emphasizing the need for careful consideration of troponin values in this population.
In the specification, disclosed is a dustproof composition including an anionic emulsification stabilizer or a thickening agent. According to an aspect, the dustproof composition of the present invention can minimize the penetration of dust, specifically, fine dust into skin. In particular, a negative charged material included as an active ingredient in the dustproof composition has a zeta potential of a negative charge similar to dust, so the attachment of dust to the surface of skin due to electrostatic power can be minimized. Moreover, even when dust penetrates into a cosmetic composition coated on skin, dust floats in an emulsification stabilizer or a thickening agent, so dust can be prevented from penetrating into skin. In particular, the penetration of fine dust into skin is prevented, and skin inflammation and heavy metal accumulation caused thereby can be minimized. Thus, the present invention is beneficial to skin health.
OBJECTIVE: This study aims to analyse high-grade intraepithelial lesions (LIEHG) observed in a screening programme from 2010 to 2018 to more accurately describe them and formulate recommendations for best practices in the context of screening evolution following the introduction of an HPV test in primary cervical cancer screening in 2020.
METHODS: This study included 305,940 asymptomatic women aged 25-65 years. The eligible population was invited to undergo a screening cervico-uterine-smear every 3 years. If this smear was normal, the woman received a new invitation. In the case of a positive screen, the patient underwent further diagnostic procedures, such as colposcopy and biopsy to confirm the diagnosis. Only those diagnosed with LIEHG and above proceeded to treatment. The diagnoses associated with LIEHG were those related to the WHO Classification of tumours of the uterine cervix.
RESULTS: Positive smears led to the diagnosis of 3230 LIEHG. The prevalence of LIEHG in the screened population was 0.4%. The LIEHG distribution varied significantly according to the age of the women. The probability of diagnosing LIEHG in young women was 12.2% at 25-29 years. This probability decreased by half after 50 years. We observed that the type of smear was significantly associated with LIEHG detection. The positive predictive value for diagnosing LIEHG was 70.3% for high-grade squamous intraepithelial lesion (HSIL) smears and 35.1% for atypical squamous cells cannot exclude HSIL (ASC-H) smears.
CONCLUSION: In the study population, the prevalence of LIEHG was high in women under 35 years. Low-grade smears were correlated with the risk of LIEHG and should prompt screening facilities to allocate resources to ensure active follow-up of LSIL and ASC-US smears. Adherence to cytological screening recommendations was associated with a reduced risk of LIEHG in multivariate analysis.
Patients planning to use PGT-A and who meet the inclusion criteria will be offered participation by their IVF physician prior to initiating cycle stimulation. Eligible and interested patients will be contacted, counseled and consented for participation in the study by a Genetic Counselor at Genomic Prediction Clinical Laboratory. This will include genetic counseling to address the benefits and limitations of PGT-A and PGT-P, the family history of diseases currently tested under PGT-P, what diseases they may be interested in testing, the process of obtaining saliva samples, and the information provided by PGT-P results.

A total of 500 patients will complete the study and may be recruited from any IVF clinic in the United States. After being enrolled in the study, patients will have two options. One option is to receive PGT-A results first and then decide if they wish to receive the PGT-P results. A second option is to receive a single comprehensive report. All patients will receive a report indicating the predicted karyotype of each embryo (PGT-A) and, according to which option they elected, may also receive a report on any or all of the following elected diseases: Type 1 Diabetes, Type 2 Diabetes, Coronary Artery Disease, Heart Attack, Hypercholesterolemia, Hypertension, Testicular Cancer, Prostate Cancer, Malignant Melanoma, Breast Cancer, Basal Cell Carcinoma. Furthermore, a genetic ancestry test will be performed on each submitted saliva sample to determine potential PGT-P performance and which disease predictors can be computed based on the patients ethnic background.
The mechanisms by which thyroid hormones exert their physiologic action are not well understood. These hormones enhance oxygen consumption by most tissues of the body, increase the basal metabolic rate and the metabolism of carbohydrates, lipids and proteins. Thus, they exert a profound influence on every organ system in the body and are of particular importance in the development of the central nervous system. 

Pharmacokinetics

Since liothyronine sodium (T3) is not firmly bound to serum protein, it is readily available to body tissues. The onset of activity of liothyronine sodium is rapid, occurring within a few hours. Maximum pharmacologic response occurs within 2 or 3 days, providing early clinical response. The biological half-life is about 2-1/2 days.

T3 is almost totally absorbed, 95 percent in 4 hours. The hormones contained in the natural preparations are absorbed in a manner similar to the synthetic hormones.

Liothyronine sodium has a rapid cutoff of activity which permits quick dosage adjustment and facilitates control of the effects of overdosage, should they occur.

The higher affinity of levothyroxine (T4) for both thyroid-binding globulin and thyroid-binding prealbumin as compared to triiodothyronine (T3) partially explains the higher serum levels and longer half-life of the former hormone. Both protein-bound hormones exist in reverse equilibrium with minute amounts of free hormone, the latter accounting for the metabolic activity.
Background: Pancreatic cancer (PaC) is a highly malignant gastrointestinal tumor with invasive and metastatic characteristics. Interleukin-6 (IL-6), a negative prognostic marker, contributes to PaC progression. However, the mechanism of IL-6 in PaC is not yet fully understood. Methods: miR-455-5p levels were first tested by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) in PaC tissues or cells. Subsequently, PaC cell-related functions were identified through CCK-8, Transwell, and Western blotting. Changes in miR-455-5p and IGF-1R expression were confirmed using RT-qPCR and Western blotting. miR-455-5p methylation was assessed by bisulfite sequencing PCR. Results: The authors discovered that miR-455-5p was expressed at low levels in PaC tissues and cells, and miR-455-5p expression was observably reduced by IL-6 in PaC cells. In addition, IL-6 dramatically induces miR-455-5p methylation in PaC cells. Functionally, the data revealed that IL-6 could facilitate the malignant properties of PaC cells, including proliferation, epithelial-mesenchymal transition, and metastasis. The authors found that miR-455-5p could suppress the progression of PaC cells by downregulating IGF-1R in PaC cells. Mechanistically, IL-6 downregulated miR-455-5p and upregulated IGF-1R, and miR-455-5p reduced IGF-1R expression through targeted binding. Conclusions: The authors demonstrated that the miR-455-5p/IGF-1R axis is necessary for the induction of IL-6 in PaC progression. The results here may provide a theoretical basis for the application of the IL-6/miR-455-5p/IGF-1R axis in the clinical therapy of PaC.
Hematologic Effects: Pioglitazone hydrochloride may cause decreases in hemoglobin and hematocrit. In placebo-controlled monotherapy trials, mean hemoglobin values declined by 2% to 4% in patients treated with pioglitazone hydrochloride compared with a mean change in hemoglobin of -1% to +1% in placebo-treated patients. These changes primarily occurred within the first 4 to 12 weeks of therapy and remained relatively constant thereafter. These changes may be related to increased plasma volume associated with pioglitazone hydrochloride therapy and are not likely to be associated with any clinically significant hematologic effects.

Creatine Phosphokinase: During protocol-specified measurement of serum creatine phosphokinase (CPK) in pioglitazone hydrochloride clinical trials, an isolated elevation in CPK to greater than 10 times the upper limit of the reference range was noted in 9 (0.2%) patients treated with pioglitazone hydrochloride (values of 2150 to 11400 IU/L) and in no comparator-treated patients. Six of these nine patients continued to receive pioglitazone hydrochloride, two patients were noted to have the CPK elevation on the last day of dosing and one patient discontinued pioglitazone hydrochloride due to the elevation. These elevations resolved without any apparent clinical sequelae. The relationship of these events to pioglitazone hydrochloride therapy is unknown.
The invention provides a ramosetron composition for injection, and relates to the technical field of medicines and medicine manufacturing. Main medicines of the composition are ramosetron and melatonin. The melatonin comprises a quick release part and a slow release part contained in cyclodextrin. The ramosetron composition for injection provided by the invention has the functions of improving the treatment effect of ranitidine, avoiding instability, fast distribution and elimination and the like of MT (Melatonin) caused by oral absorption, reducing the first pass effect of MT and reducing the dosage of ramosetron. Delivery design combining quick release and slow release meets the physiological secretion characteristic of MT, solves the problem of short half life of MT and improves the bioavailability of the product. The composition has a synergistic effect on treatment of CINV (Chemotherapy Induced Nausea And Vomiting) by ramosetron, and after the melatonin is combined with ramosetron, not only is the CINV treated, is the treatment effect of the ramosetron on the CINV improved and is the course of treatment shortened, but also the use level of the ramosetron and the side effect of the ramosetron are reduced, and the immunity of human body is improved. The melatonin in a certain concentration in human blood has the capability of effectively reducing melatonin of human body to the benefit of treatment of the CINV.
The purpose of this research is to study areas of the brain that may have something to do with repetitive movements (things that people do over and over again) and difficulty communicating with other people (problems with talking to, understanding, or just being in a relationships with other people). The investigators are trying to find out why these brain areas are working differently in people with developmental disorders, such as Autism and how the investigators can one day improve them with new brain stimulation techniques.

The investigators will do screening to make sure that you are eligible for the study. After screening, the investigators will do functional MRI. In this procedure the subject or the control will be looking at videos developed to understand their social communication and language skills. The investigators will be able to understand differences of brain activation between patients and control. The investigators will also use TMS to identify the difference of motor excitability between patients and healthy control.
The patient were retrospectively included according to the last digit of their admission number (odd number). The had arterial blood gas analysis every 4 hour during the ICU stay.
ETHNOPHARMACOLOGICAL RELEVANCE: Zhisou Powder (ZP), one of the most common prescriptions in traditional Chinese medicine, has been widely used in the treatment of acute or chronic bronchitis and chronic cough. The ZP was composed of Ziwan (Aster tataricus L. f.), Jiegeng (Platycodon grandiflorus (Jacq.) A. DC.), Jingjie (Nepeta cataria L.), Baibu (Stemona sessilifolia (Miq.) Miq.), Baiqian (Vincetoxicum glaucescens (Decne.) C. Y. Wu & D. Z. Li), Chenpi (Citrus × aurantium f. deliciosa (Ten.) M. Hiroe) and Gancao (Glycyrrhiza uralensis Fisch. ex DC.), with plant names among it checked with MPNS (http://mpns.kew.org). But until now, the key active components and targets of ZP, and related mechanism of ZP in the treatment of chronic bronchitis (CB) remain unclear.
AIM OF THE STUDY: This study combined UPLC-Q-Exactive-Orbitrap-MS, network pharmacology, metabonomics with experiment verification to explore potential mechanism of ZP in the treatment of CB.
MATERIALS AND METHODS: UPLC-Q-Exactive-Orbitrap-MS was performed to analyze the chemical components of ZP. The potentially effective components, attractive targets and critical signaling pathways of Zhisou Powder in the treatment of CB were screened by UPLC-Q-Exactive-Orbitrap-MS combined with network pharmacology. Additionally, the CB model rats induced by SO2 were used to evaluate the anti-chronic bronchitis activity of ZP in vivo. The pulmonary pathology was determined by hematoxylin-eosin staining. Meanwhile, PI3K/Akt/HIF-1α/VEGFA signaling pathway predicted from network pharmacology was verified by Western blot and RT-PCR. Lastly, the metabolic changes of arachidonic acid (AA) in ZP-treated rats were quantitatively analyzed by LC-MS targeted metabonomics, and the proteins expression involved in AA metabolic pathway were detected by immunohistochemistry, immunofluorescence and Western blot.
RESULTS: The main active components of ZP in the treatment of CB selected by network pharmacology and UPLC-Q-Exactive-Orbitrap-MS technology were quercetin, kaempferol, luteolin, galangin, isorhamnetin, naringenin, nobiletin, formononetin and so on. The core targets of these components were predicted to be TP53, TNF, IL-6, VEGFA, CASP3, IL-1β, JUN, PTGS2. Enrichment of KEGG pathway analysis found that PI3K/Akt/HIF-1α/VEGFA signaling pathway might play a key role in the treatment of CB with ZP. The in vivo study showed that ZP significantly improved the pathological changes of SO2-treated lung tissue and inhibited the activation of PI3K/Akt/HIF-1α/VEGFA signaling pathway. The changes of AA and its metabolites in vivo were studied by targeted metabonomics, and it showed that ZP could reprogram the disorder of AA metabolism which contributed to the treatment of CB with ZP.
CONCLUSION: ZP displayed good therapeutic effect on CB model rats through inhibiting PI3K/Akt/HIF-1α/VEGFA signaling pathway to exhibit anti-inflammatory effect and reprogramming disordered metabolic pathway of arachidonic acid.
Interventions：Goserelin+TAM+AI：Goserelin 3.6mg subcutaneous injection per 4 weeks, for 16-20weeks. TAM 10mg oral twice a day for the first four weeks(to wait the Goserelin start to work in body) than change to AI 1mg oral once a day with Goserelin for the next 12-16 weeks.
PURPOSE:To prepare a therapeutic agent for adult respiratory distress syndrome initiated subsequently to trauma, sepsis, etc., comprising a specific carbostyril derivative (salt) as an active ingredient, capable of promoting the termination of inflammatory reactions due to a neutrocyte based on promoting action on apoptosis. CONSTITUTION:This effective therapeutic agent for adult respiratory distress syndrome (ARDS) is obtained by using a carbostyril derivative of the formula (R is benzoyl which may have a lower alkoxy group on the phenyl ring; the bond between the carbon atoms at the 3-and 4-positions of the carbostyril skeleton denotes single or double bond) {e.g. 6-[4-(3,4-dimethoxybenzoyl)-1- piperazinyl]-3,4-dihydrocarbostyril} and/or its salt as an active ingredient, adding an additive such as an excipient (e.g. starch), a lubricant (e.g. magnesium stearate) and a disintegrating agent (e.g. lactose) thereto and forming the resultant blend into a tablet. This medicine is capable of promoting the termination of inflammatory reactions due to a neutrocyte based on promoting action on apoptosis.