anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The chances of conception decrease and miscarriage increase with a women's age, and the locus of reproductive aging is the egg (1). Egg dysfunction affects most women beginning by their late '30's and for many women age related egg dysfunction represents a major cause of infertility. The cause of age related egg dysfunction is poorly understood, but telomere dysfunction may play an important role. Our group has demonstrated that genetic or pharmacologic shortening of telomeres in the eggs of mice, which normally do not exhibit age related egg dysfunction, mimics reproductive aging in women, with cell cycle arrest, apoptosis, spindle dysmorphologies and chromosomal abnormalities (1,2). Moreover, a pilot study the investigators conducted five years ago suggested that telomere length of spare human eggs may predict the outcome of womens' InVitro Fertilization (IVF) cycles (3). Subsequently, other investigators have demonstrated that telomere length of circulating leukocytes predicts miscarriages (4).
The present invention provides nucleic acid molecules that can function as PCR  primers for the detection of contactin mRNA in a sample. Such nucleic acid molecules can be labeled and can be provided in a kit. The present invention also includes a method of detecting the presence of a neurodegenerative disease such as multiple sclerosis, including providing a sample from a patient and measuring the amount of contactin protein or contactin mRNA  expressed in the sample. The present invention further provides a method for identifying which patents having a neurodegenerative disease are likely to respond to a treatment for a neurodegenerative disease. The present invention further includes compositions of matter that include an isolated cell or a cell in culture that expresses an increased or decreased amount of contactin as compared to a control cell. The present invention also includes a method for screening compounds for the activity of reducing or enhancing the expression of contactin and compositions or compounds, including pharmaceutical compositions, identified by this method. Also included are methods of treating a neurodegenerative disease using such compositions or compounds. The present invention also includes methods of identifying pharmaceutical targets for compounds that modulate contactin expression or activity and targets identified by such methods.
FIELD: organic chemistry, natural compounds, pharmacy. SUBSTANCE: invention relates to tetracyclic analogues of camptothecins of the formula (I)   wherein R 1 ,R 2 ,R 3 ,R 4 ,R 5 ,R 10  are given in the invention claim. Invention describes also intermediate compounds and pharmaceutical composition used for inhibition of topoisomerase=I and II activity. Invention can be used in medicine as a therapeutic agent for treatment of cancer diseases. Invention provides preparing new compounds eliciting valuable pharmacological properties. EFFECT: improved preparing methods, valuable medicinal properties of compounds. 16 cl, 2 tbl, 14 ex
The present invention discloses a system and method for improving the quality of life in canines and other domesticated animals. As animals age testosterone and other supportive hormones diminish causing reduced activity, a lack of mobility, decreased bone density, and general well-being. Precursor compositions are selected and designed for the purpose of formulating non-toxic therapeutic hormone supplements for oral consumption. The process and method of this invention is comprised of therapies produced from two or more selected non-toxic prohormones that combine during digestion and delivered through a chewable and edible gummy treat. As such there is no requirement for changing the subject's current diet. The present invention features a continuous low dose supplementation to be incorporated daily whereby dosages are correlated according to the subject's age, weight, sex, and breed. The beneficial results of the present invention are achieved through the absorption of the prohormones in the composition into the bloodstream effecting delivery to all cells including those specific cells where the conversion enzymes are activated by the organism's needs. The delivery and transport of inactive prohormones minimizes liver toxicity since the precursors are carried through the hepatic portal system to and through the liver and into general circulation in inactive forms.
Participants will receive a single injection of DNA Mosaic env at Months 0, 1, and 2. They will receive a single injection of MVA-CMDR at Months 4 and 8.
A system and method for managing data in a healthcare environment can include a content based router, and a healthcare record bank. The content based router can be configured to collect the data from a clinical data provider and convert the data in a format in accordance with a defined standard. The healthcare record bank can include or be coupled to a data repository. The healthcare record bank can be configured to be coupled to the clinical data provider through the content based router over a communication network. The healthcare record bank can be configured to store the data received from the clinical data provider and can be accessible or searchable from within or outside the healthcare record bank. The healthcare record bank can be coupled to or include a data logging unit configured to maintain metadata associated with the clinical data and configured to facilitate natural language processing capabilities.
ARNi (initial dose 24/26mg b.i.d. or 49/51mg b.i.d. titrated to 97/103mg b.i.d. preferably in the first 3-6 weeks, up to 3 months of follow-up) and SGLT2i (10mg q.d.) on the same day or within ± 5 days.
Previous studies suggest that interference control may be unaffected by sleep deprivation based on the unchanged interference effects (reaction time [RT] differences between incongruent and congruent conditions), while ignoring the overall slower RTs after sleep deprivation. In the present study, we interpreted these results from a new angle using a variant of diffusion model, diffusion model for conflict tasks (DMC), and investigated whether and how interference control is affected by sleep deprivation. Mathematical derivations and model simulations showed that unchanged task-irrelevant information processing (i.e., unaffected interference control) may not lead to the observed unchanged interference effects when considering the overall slower RTs after sleep deprivation (due to either decreased drift rate of task-relevant information or increased decision boundary). Therefore, the unchanged interference effects do not necessarily indicate unchanged interference control. We then conducted a Simon task following one night of sleep deprivation or normal sleep, and fitted the DMC to the data. Experimental results showed that the Simon effect was reversed when most of the trials were incongruent, indicating that participants used learned spatially incompatible stimulus-response associations to predict responses. However, the Simon effects in both mean RTs and RT distributions were not significantly modulated by sleep deprivation. Model fits showed that the drift rate of task-relevant information decreased and the time-to-peak of task-irrelevant activation increased after sleep deprivation. These results suggest that central information processing was degraded after sleep loss, and most importantly, task-irrelevant activation increased after sleep deprivation as interference control was impaired. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
Participants will receive 4 weeks Mildly Thick, 4 weeks Extremely Thick, 4 weeks Mildly Thick and 4 weeks Extremely Thick blenderized tube feeds. The volume, caloric density and frequency will be matched to pre-study feeding regimen.
Given the current opioid crisis, in this study, we assess the national trend and factors associated with opioid administration for patients presenting to the emergency department with abdominal pain. This is a retrospective cross-sectional study conducted using the National Hospital Ambulatory Medical Care Survey from 2010 to 2018. Weighted multiple logistic regression was applied to assess the independent factors associated with opioid administration in the emergency department. Trends of opioid administration were evaluated using the linear trend analysis. There were an estimated total of 100,925,982 emergency department visits for abdominal pain. Overall, opioid was administered in 16.8% of visits. Age less than 25 years was associated with lower odds of receiving opioids. Patients living in the Northeast had the lower odds of receiving opioids (odds ratio [OR] = 0.82, p = .006) than patients living in the Midwest. Patients in the West had the highest odds of receiving opioids (OR = 1.16, p = .01). Non-Hispanic White patients had higher odds of opioid administration (OR = 1.29, p < .001). Trend analysis demonstrated a statistically significant reduction in opioid administration. From 2010 to 2018, opioid administration has approximately decreased in half. Living in the West and the non-Hispanic White racial group were the significant factors associated with a higher risk of opioid administration.
Half of the subjects will be randomized to Transforming Powder Dressing (TPD) to treat the burn wound(s). Subjects will be evaluated on Treatment Day 0, 3, 7, 10, 14, 21, and 28 (or sooner if the wound heals prior to end of study visit on Day 28). On each study visit, wound care will be performed. TPD will be applied directly on the burn wound, followed by another dressing (often called a secondary dressing).
Procedure 3: 10-day induction with buprenorphine administered daily and increasing daily doses of oral naltrexone beginning on day 2 . On day 10 participants will receive XR-NTX dose, and another one 4 weeks later. Buprenorphine will continue for 4 weeks until the 2nd XR-NTX dose.
A system, method, and program support a flexible framework for providing communications between the layers of a software application. A processing unit is operable to execute a communications API (Applications Program Interface), the communications API virtually or effectively interconnecting presentation logic and business logic associated with a software application. The communications API transparently and interchangeably executes desktop implementation of the software application and a network implementation of the software application. The desktop implementation, the network implementation, and any switching between implementation modes may be transparent to the presentation logic and/or the business logic. The software application may be an n-layer application, and the communications API may arrange the order of the n-layers based upon whether desktop or network implementation is to be employed. The presentation logic and business logic may be associated with different machines located at a distance.
Soy protein alone without soy isoflavone or cocoa polyphenol. 2 bars daily for 8 weeks.
The invention discloses a full-fermentation rose red wine and a preparation process thereof. The production process comprises the following steps: (1) Removing pedicel of flos Rosae Rugosae to obtain pest-free, mildew-free and disease-free flos Rosae Rugosae petals, adding concentrated juice of fructus Lycii into a tank, adding water, sucrose, yeast strain fermentation liquid, controlling temperature, and performing primary fermentation; and (2) fermenting and ageing. The alcoholic strength of the fermentation liquor is 11-14 degrees, the fermentation is finished when the sugar is lower than 4m/L, and the residue is filtered. Chen Niangzhong adding bentonite for stabilization treatment, and separating clear juice. Membrane filtering and canning to obtain rose red wine base wine. (3) And (3) blending the dried red wine base of the roses and fructooligosaccharides in different years to obtain the rose wine. The invention has the beneficial effects that: the product has pure and coordinated fragrance, clean and fresh taste, plump and mellow wine body, lasting aftertaste and unique style, is flavored by utilizing fructo-oligosaccharide, has good taste, has the functions of promoting intestinal tract circulation, promoting digestion, expelling toxin and beautifying, and has low calorie, and is suitable for people pursuing health to drink.
Patients receive an influenza vaccine IM on day 0 and intratumorally on days 2 and 14 in the absence of disease progression or unacceptable toxicity. Patients then undergo surgery on day 28.
BACKGROUND AND OBJECTIVES: Natural history of hemorrhage in brain arteriovenous malformations (bAVM) is reported at 2%-4% per year. Published studies using survival analysis fail to account for recurrent hemorrhagic events. In this study, we present a large, single institution series to elucidate the natural history of bAVM using multivariable Poisson regression.
METHODS: This is a retrospective cohort study. All patients with bAVM seen at our institution from 1990 to 2021 were included. Hemorrhages after detection of bAVM during the untreated interval were recorded. Natural history of hemorrhage was calculated by dividing number of hemorrhages by untreated interval. The frequency of hemorrhages followed a Poisson distribution. Multivariable Poisson regression with an offset variable of untreated interval in patient-years was constructed. Model selection was through a stepwise Akaike information criterion method. Stratified hemorrhagic rate was presented using different combinations of significant factors.
RESULTS: A total of 1066 patients with nonhereditary hemorrhagic telangiectasia harboring a single bAVM were included. Ninety (8.44%) patients had 101 hemorrhages during an untreated interval of 3596.3344 patient-years, translating to an overall hemorrhagic rate of 2.81% per year. Significant factors increasing hemorrhage risk included ruptured presentation ( P < .001), increasing age ( P < .001), female sex ( P = .043), and deep location ( P = .040). Adult male patients with ruptured presentation and deep bAVMs sustained the highest annual risk at 10.81%, whereas no hemorrhages occurred in unruptured pediatric male patients or ruptured pediatric (younger than 18 years) male patients with superficial bAVMs.
CONCLUSION: Hemorrhage after bAVM detection occurs in 8.41% of all patients, and the rate averages 2.81% per year. However, this risk varies from 0.00% to 10.81% per year depending on various risk factor combinations. Efforts should be made to stratify bAVM hemorrhage rate by risk factors for more precise estimation of bleeding risk if left untreated.
Despite advances in preoperative patient's selection and anesthetic and surgical techniques, surgery in jaundiced patients is associated with significant morbidity and mortality as a consequence of septic complications. The evidence that nosocomial infections are frequently a consequence of gut-derived organism such as enterobacteriaceae, supports the hypothesis of the "gut derived sepsis". Indeed, several studies have reported that jaundiced patients present an increased intestinal permeability and consequently a higher rate of bacterial migration from gastrointestinal tract across the lamina propria to local mesenteric lymph nodes and from there to extra-intestinal site. This phenomenon increases after surgical decompression of bile duct. The higher prevalence of bacterial translocation in jaundiced patients is related to different mechanisms such as mucosal atrophy secondary to protracted absence of intraluminal bile that open para-cellular route for bacterial translocation and the decreased clearance capacity of Kuppfer secondary to cholestasis.

The mechanisms of action of symbiotics are largely unknown. The probiotic bacteria can improve the mucosal barrier function reducing the bacterial translocation of organism to mesenteric lymph nodes. Indeed symbiotic can affect the intestinal ecosystem by stimulating mucosal immune and non-immune mechanisms through antagonism/competition with potential pathogens.
Traditionally, aborted cardiac arrest (ACA) due to documented ventricular fibrillation (VF) in the absence of structural heart disease has been termed idiopathic VF. By careful evaluation, a specific etiology can be found in a substantial proportion of patients. The aim of this survey was to assess the yield of an advanced diagnostic work-up to reveal a causative etiology in a real-life clinical setting. Patients from the University Hospital Brno's ACA database were analyzed (514 patients in total). Forty-six patients (31 males) fulfilled the inclusion criteria, which were: (1) absence of structural pathology on echocardiography; (2) absence of coronary artery disease; and (3) absence of reversible cause of ACA. The diagnostic work-up consisted in cardiac magnetic resonance imaging, stress testing, sodium channel blocker challenge, and genetic testing according to the availability of the method and patient compliance. A specific disease was found in 17 individuals (37.0%), although at least one diagnostic step was refused by 13 patients (28.3%). True idiopathic VF was confirmed in 7 patients (15.2%), for whom the entire diagnostic work-up did not reveal any specific pathology. Our real-life survey shows that, even with an incomplete diagnostic work-up (due to the unavailability of a particular method or variable patient compliance), a specific diagnosis can be identified in more than one third of the cases of "idiopathic" VF, which can thus enable targeted treatment and family screening.
Zeolites of small and uniform size are formed having high magnesium exchange capacities. Zeolite A is disclosed having an average particle size less than 1.7 microns, a calcium carbonate exchange capacity of more than 230 mg calcium carbonate per gram zeolite and a magnesium exchange capacity of more than 140 mg magnesium carbonate per gram zeolite. This zeolite A is produced from a reaction mixture having a water to sodium oxide molar ratio of less than 35:1, and a sodium oxide to silica molar ratio of between 1:1 and 4:1, wherein the silica to alumina molar ratio is greater than 3:1 when the sodium oxide to silica molar ratio is less than 4:3 and the sodium oxide to alumina molar ratio is greater than 4:1 when the sodium oxide to silica molar ratio is greater than 4:3. Zeolite X is disclosed having an average particle size less than 2.2 microns, a calcium carbonate exchange capacity of more than 205 mg calcium carbonate per gram zeolite, and a magnesium exchange capacity of more than 130 mg magnesium carbonate per gram zeolite. This zeolite X is produced from a reaction mixture having a silicate alumina molar ratio greater than 5:1. A combination of zerolite A and zeolite X can be produced from the same reaction mixture.
Mental fatigue is a commonplace human experience which is the focus of a growing body of research. Whilst researchers in numerous disciplines have attempted to uncover the origins, nature, and effects of mental fatigue, the literature is marked by many contradictory findings. We identified two major methodological problems for mental fatigue research. First, researchers rarely use objective measures of mental fatigue. Instead, they rely heavily on subjective reports as evidence that mental fatigue has been induced in participants. We aimed to develop a task which led to not only a subjective increase in mental fatigue, but a corresponding performance decrement in the mentally fatiguing task as an objective measure. Secondly, current mental fatigue paradigms have low ecological validity - in most prior studies participants have been fatigued with a single repetitive task such as the n-back or Stroop. To move towards a more ecologically valid paradigm, our participants undertook a battery of diverse cognitive tasks designed to challenge different aspects of executive function. The AX-CPT, n-back, mental rotation, and visual search tasks were chosen to challenge response inhibition, working memory, spatial reasoning, and attention. We report results from 45 participants aged 19 to 63 years who completed a two-hour battery comprising four different cognitive tasks. Subjective fatigue ratings and task performance were measured at the beginning and end of the battery. Our novel method resulted in an increase in subjective ratings of fatigue (p < 0.001) and a reduction in task performance (p = 0.008). Future research into mental fatigue may benefit from using this task battery.
PURPOSE:To obtain test animal useful for judging effect of remedy drug for Alzheimer type dementia by administering combined body of nerve growing factor and nerve cell toxin to brain cortex and/or hippocampus of mammal other than human and selectively destroying cholinergic neuron. CONSTITUTION:1.5-3 molecules of nerve growing factor (e.g. 2.5S.NGF) are reacted with a molecule of nerve cell toxin (e.g. diphtheria toxin) in the presence of water-soluble condensation agent [e.g. 1-ethyl-3-(3-L-dimethylaminopropyl) carbodiimide] in a solvent (e.g. water) at pH5.5-8.0 to obtain combined body of the nerve growing factor and nerve cell toxin. Next, 0.5-30mug said combined body is administered to brain cortex and/or hippocampus of mammal (e.g. rat) other than human and the mammal is bred for 3-7 day to selectively destroy cholinergic neuron projected to brain cortex from Meynert nucleus or bottom part of fore-brain and/or cholinergic neuron projected from septal body.
In hemodialysis patients, deviations of serum concentration of calcium, phosphate or parathyroid hormone from the values recommended by KDIGO are associated to a negative outcome. The regulation of calcium, phosphate and parathyroid hormone is complex and each parameter is not independently regulated. In hemodialysis patient's simultaneous modification in these three parameters are the result of abnormal mineral metabolism and the treatment used to correct these abnormalities that usually produce changes in more than one parameter. The specific objective of this work is an accurate and exhaustive analysis and description of the complex relationships between clinically relevant parameters in chronic kidney disease metabolism bone disease. In order to achieve these objectives we have used a machine learning approach Random Forest able to extract useful knowledge from a large database. The analysis of the complex interactions between the different parameters needs an advance mathematical approach such as Random Forest . The second aim of this study is to determine whether calcium, phosphate and parathyroid hormone, Fibroblast growth factor 23 and calcitriol are long-term associated with demographic features, mortality, co-morbidity and the therapy prescribed. Compare the predictions obtained with conventional statistical analysis versus the new model analysis based on artificial intelligence. Our preliminary results suggest that there are interactions between some parameters that are strong enough to question whether the evaluation of a given therapy can be based in the measurement of one single parameter. Subsequently, we will analyze in a prospective study on incident patients, whether the use of this new model may predict the cardiovascular risk and reduce the therapy cost.