anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
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The present invention relates to a novel human immunodeficiency virus (HIV) capable of inducing lymphadenopathies (LAS) and acquired immune deficiency syndromes (AIDS) in patients which has been designated the lymphadenopathy associated virus strain MAL (LAV MAL ). Although the overall genomic organization of LAV MAL  is similar to other known HIV-1 isolates such as LAV BRU  and HTLV-III, nevertheless, this virus also displays considerable genotypic and phenotypic diversity as compared to these isolates. A proviral molecular clone of the virus was obtained and characterized. The complete nucleotide sequence of this clone was ascertained and putative regulatory regions (e.g., U3, R, U5,), regulatory elements (e.g., the TATA box, AATAAA polyadenylation signal, primer binding site), and open reading frames (e.g., Gag, Pol, Env, Vif, Vpr, Tat, Rev, Nef) identified. Of particular interest are unique polypeptides derived from the viral envelope. The claimed invention is directed toward isolated LAV MAL  Env polypeptides consisting of 5-150 amino acids wherein said peptides contain a LAV MAL -specific epitope. These peptides will prove useful, inter alia, as diagnostic reagents and in the generation of immunological reagents for the detection of the virus.
Psoriasis is associated with cardiometabolic comorbidities, including obesity, diabetes, hyperlipidaemia and hypertension. Many studies that established these associations originated from primarily White and/or relatively affluent populations. To evaluate whether there is a differential risk for cardiometabolic comorbidities in racial/ethnic minorities, we performed a cross-sectional analysis comparing cardiometabolic comorbidities between those with and without psoriasis in a racially and ethnically diverse population of 56 987 low-income patients, stratified by race/ethnicity, and assessed whether race/ethnicity acts as an effect modifier for cardiometabolic comorbidities. We found that psoriasis was statistically significantly associated with obesity, diabetes, hyperlipidaemia and hypertension. The association of psoriasis with comorbidities did not differ significantly by race/ethnicity; thus, we did not find evidence of effect modification. However, our diverse, low-income population had an extremely high baseline prevalence of cardiometabolic comorbidities compared with previous populations studied. Our results suggest education and intervention regarding modifiable risk factors are particularly important among vulnerable populations.
Postoperative cognitive dysfunction (POCD) is a disease with restricted cognitive memory function and intellectual skills, which occurs after surgery with and without anesthesia. The limiting cognitive ability leads to a lack of quality of life for a lot of patients. The POCD strongly depends on patient's age and the surgical operation type. In aged adults the incidence of POCD after one week following surgery is 25,8%. Risk factors for the development of a POCD is beside age less education and a reduced cognitive reserve. However, the anesthesia procedure plays a pivotal role as well and regarding the current knowledge it is still uncertain which technique matches the lowest risk. Elevated stress level accompanied with regional anesthesia procedures are accused to cause POCD in elderly patients. This fact leads to the question if a general anesthesia technique has a lower stress level and consequently leads to a reduced risk for a POCD development. Likewise the investigators address this hypothesis and analyze cognitive function following both anesthesia techniques separately in elderly patients.
Patients receive tremelimumab over 1 hour on day 1 and CD40 agonist monoclonal antibody CP-870,893 IV over 30 minutes on days 2, 22, 43, and 64. Treatment repeats every 12 weeks for up to 4 courses in the absence of disease progression or unacceptable toxicity.
OBJECTIVE: The aim of this study was to evaluate the association between nutritional status, inflammation, and susceptibility to seizures in febrile children.
METHODS: This observational single-center study was carried out from January 2020 to December 2023 with 324 children aged 6 months and 6 years; 106 were diagnosed with febrile seizure, 108 were febrile children, and 110 were healthy controls. The prognostic nutritional index and neutrophil-to-lymphocyte ratio were calculated, and the cutoff threshold was established through receiver operating characteristics. The study utilized correlation and univariate-multivariate logistic regression analysis. The comparison between simple and complex febrile seizure was conducted to analyze differences.
RESULTS: The optimal cutoff values were identified as 61.25 for prognostic nutritional index and 1.04 for neutrophil-to-lymphocyte ratio. Our findings showed a significant negative association between febrile seizure and platelet count, high C-reactive protein, and high ferritin levels. Additionally, the febrile seizure group showed a significant positive correlation with high neutrophil-to-lymphocyte ratio values (≥1.04) and body temperature (≥38). Our findings revealed that high neutrophil-to-lymphocyte ratio, high C-reactive protein, and age less than 18 months were independently associated with seizure susceptibility in febrile children.
CONCLUSION: High neutrophil-to-lymphocyte ratio values and low prognostic nutritional index scores may serve as novel surrogate independent factors for seizure susceptibility in febrile children. Febrile children who are less than 18 months old are more prone to experience seizures than older febrile children. Moreover, there was a correlation between febrile seizures and elevated C-reactive protein levels and neutrophil-to-lymphocyte ratio values.
Systemic lupus erythematosus (SLE) is a common autoimmune disease marked by the formation of apoptotic debris and the presence of autoantibodies that target nuclear components. At this moment, the actual cause of SLE is uncertain. Genetic variables have been well proven to have a significant role in the propensity of SLE. This study aimed to investigate the effect of (ZNF76) rs (10947540) and (SCUBE) rs (1888822) gene polymorphism in patients with systemic lupus erythematosus. A case control study has been carried out at Medical Biochemistry & Molecular biology and Rheumatology unit of Internal Medicine Departments, Faculty of Medicine, Menoufia University, Egypt, for 1-year duration between 1 June 2022 and 1 June 2023. Sixty patients were females (75%) and twenty patients were males (25%). Their ages ranged from 19 to 53 years. Their disease durations ranged from 7 months to 20 years. The findings indicated that the TC genotype of the ZNF76 rs10947540 gene increases the risk of SLE by 2.274-fold, while the dominant TC + CC increases the risk by 2.472-fold, and the C allele increases the risk by 2.115-fold. Additionally, the results showed that the TT genotype of the SCUBE3 rs1888822 gene increases the risk of SLE by 3.702-fold, the dominant GT + TT increases the risk by 2.304-fold, and the T allele increases the risk by 2.089-fold, while the GT genotype increases the risk by 1.918-fold. The study revealed significant associations between the genotypes of these polymorphisms and certain clinical parameters in SLE patients. These findings highlight the potential genetic contributions to SLE susceptibility and its clinical manifestations, providing valuable insights for future research and potential personalized approaches to the management of this complex autoimmune disease.
Infectious diseases pose a severe threat to human health and are accompanied by significant economic losses. Studies of urban outbreaks of infectious diseases are diverse. However, previous studies have neglected the identification of critical events and the evaluation of scenario-based modeling of urban infectious disease outbreak emergency management mechanisms. In this paper, we aim to conduct an empirical analysis and scenario extrapolation using a questionnaire survey of 18 experts, based on the CIA-ISM method and scenario theory, to identify the key factors influencing urban infectious disease outbreaks. Subsequently, we evaluate the effectiveness of urban infectious disease outbreak emergency management mechanisms. Finally, we compare and verify the actual situation of COVID-19 in China, drawing the following conclusions and recommendations. (1) The scenario-based urban infectious disease emergency management model can effectively replicate the development of urban infectious diseases. (2) The establishment of an emergency command center and the isolation and observation of individuals exposed to infectious diseases are crucial factors in the emergency management of urban outbreaks of infectious disease.
The invention discloses a preparation method of an oral first-aid liquid for treating whole blood elevation of human body, which mixes a plurality of natural Chinese herbal bacteriophages, old and new patent Chinese medicines, and nutrition tonic foods together. The firs-aid liquid, which is boiled off for a long time by natural mineral water, is a highly concentrated one that is packed in bottles with certain weight and has a ten-year storage life. The first-aid liquid can treat pathogen diffusiveness and virus diffusiveness of the body caused by malignant tumor and all kinds of terminal cancers and leads the body hematopoiesis to decrease, and life in imminent danger. As long as 0.5 to 1.5 kilograms of body special-efficacy nutritious hematopoiesis first-aid liquid is taken orally in 24 hours, body can be urged to propagate hemopoietic blood stem cell with large quantity, and cause body blood quantity to become more, therefore, patients can get out of life risk. More particularly, the first-aid liquid is helpful for pregnant woman to generate blood as well as protect and nourish the fetus, and for breast feeding women to form blood in large quantity and yield milky juice. Especially, the first-aid liquid can help workers who are too busy to eat or sleep to form blood so as to prevent Sub-health and sudden death caused by hungriness from happening. For the aged who are older than 60 years and persist in taking the oral first-aid liquid, the oral first aid liquid can form blood in large quantity and prevent senescence of cells and organs of body, lead chronic disorder to recover slowly without pain, prolong life to 100 - 150 years old, and also can replace three meals a day of the aged, cause the aged to be full of energy without eating meals, grow younger and younger, lead the bald of people to grow new hair. Furthermore, the first-aid liquid can be served as combat food for special troops.
FIELD: medicine, oncology, pharmacy. SUBSTANCE: binding agent: conjugate of the general formula: [A-O-W-Z] a -T where T - carrier fragment; A-O-W is a residue of therapeutically acceptable anthracycline; Z - spacer group. Conjugate is synthesized by condensation of compound of the formula A-O-W-OH or its activated derivative with a substance (or their mixture) that is a spacer group Z, and with carrier fragment T. Condensation can be carried out in the presence of condensing agent. T - T-cellular antibodies, antibodies raised against CD5, transferrin receptors and others. Invention claims the compound of the formula A-O-W-[piperazine]-H that can be used for conjugate preparing. Invention can be used for treatment of some tumors in mammalian. EFFECT: improved therapeutic effect of drugs, decreased toxic effect after administration into body. 13 cl, 4 tbl
Normally, cardiovascular function declines with age. Furthermore, cardiovascular function declines with immobility, promoting other adverse effects such as postural hypotension, impaired cardiac function, and thrombogenic events. Bed rest, a condition normally used in the management of many chronic pathologies in elderly people, leads to significant functional decline, reduction in physiologic reserve of most of the organ systems, including further cardiovascular decline. Fortunately, several studies have suggested interventions that may counteract immobility-induced cardiovascular dysfunction and ensure beneficial adaptations in the aging population. For example, passive mobilization of the limbs has been shown to improve cardiovascular function in bedridden oldest-old. However, the effect of passive mobilization on NO-mediated endothelial function have not been studied yet. Thus, the main aim of the study is to determine whether passive mobilization is an effective strategy to counteract endothelial dysfunction in bedridden oldest-old. For this purpose, bedridden individuals will be recruited and randomly assigned to two groups: one group will undergo passive mobilization treatment (PM) in addition to standard therapies, the other group (CTRL) will undergo standard therapies only. On the basis of preliminary data on a subgroup of ten participants, a sample of eighteen individuals will be allocated in each group so to reach a statistical power \>0.80 and an alpha \<0.05. The PM treatment will include knee flexion-extension and it will be performed for 30 minutes, 2 times a day, 5 days a week for 4 weeks.

Before, after the 4-week treatment, and 1 month after the end of the treatment NO-mediated endothelial function of all participants will be evaluated by means of flow-mediated dilation and passive limb movement tests.
Intratympanic injection of autologous blood monocyte vesicles, once every two days, three times in total. Autologous blood monocyte vesicles were extracted from 50 ml peripheral blood from patients and dissolved in 0.2 ml of lidocaine injection and 0.8 ml of sterilized injection water.
The invention is to use camel milk and rosiglitazone maleate for combined treatment of type II diabetes, and relates to the field of medicine. It was reported that camel milk can reduce trypsin dosage for patients with type I diabetes mellitus. But there is no report about the effect of camel milk on type II diabetes. The experiment of the invention indicates that drinking camel milk alone has the same effect with rosiglitazone maleate in reducing blood sugar, blood lipid, and trypsin. Combined drinking of rosiglitazone maleate 4mg and camel milk 8ml once each day has better therapeutic effect than exclusive use of rosiglitazone maleate in reducing blood sugar, blood lipid, and trypsin. The invention has the advantages of convenient administration and low cost, and also is benefit for the economical development of pastoral zone.
Disclosed herein are various embodiments of systems and methods that may be utilized in a variety of videoconferencing applications. According to various embodiments, techniques may be utilized to dynamically allocate and adjust bandwidth utilization during a videoconferencing session. A data network may allow for the transmission of data between two or more endpoints. The data exchanged between the endpoints may include video data, audio data, control data, and status data. Control data may be utilized in various embodiments to operate a robotic videoconferencing endpoint. Accordingly, various components of a data network connecting videoconferencing endpoints may transmit data wirelessly.
Participants in this group will receive an injection of the VRC-HIVDNA044-00-VP vaccine at study entry and Months 1 and 2, followed by an injection of VRC-HIVADV027-00-VPat Month 6. There will be 13 study visits for this group.
PURPOSE:To obain a drug effective to promote the restoration of patient, by removing the toxicity of swellfish liver oil having high acidity by a specific method, thereby utilizing the sterilizing activity of the fatty acid of the oil. CONSTITUTION:Raw leaves of a tree (especially cedar leaves) are boiled in water, and the decocted liquid is concentrated with heat. The concentrate is mixed with the liver oil of swellfish. The mixture is boiled for about 30 minutes, left to cool, poured into a glass cylinder, and allowed to separate into two layers. The liver oil mixture is decomposed by boiling producing an egg-yellow coagulate. The egg-yellow top layer is collected, and the pale red lower layer is discarded. The collected top layer liquid is free from glycerol, and nontoxic. A mixture of the liquid with iron powder magnetized to <=1,000 Gauss is useful as an internal drug for tubeculosis, abdominal typhus, etc. or an external drug suitable for varios dermatitis and for sterilization.
The laser scanner, 50 cm from the skin, will target the area from the 12th ribs to the upper iliac crest, 4.2 cm lateral to the spine. The sciatic, tibial, and peroneal nerves will also be irradiated.
Tislelizumab (BGB-A317) 200mg will be administered on Day 1 of each 21-day cycle (once every 3 weeks) in combination with pemetrexed. And pemetrexed 500 mg/m2 will be administered on Day 1 of each 21-day cycle (once every 3 weeks).
PROBLEM TO BE SOLVED: To extract a pharmacodynamic ingredient and obtain an extract free from adverse effect and excellent in pharmacodynamic property by adding an alcohol extract of Impatience balsamina L. to a substance used for crude medicines, etc. SOLUTION: An alcohol extract of Impatience balsamina L. obtained by immersing 2-5 pts.wt. whole grass of Impatience balsamina L. into 10 pts.wt. ethyl alcohol-containing aqueous solution having >=10 degree and separating the residue is added to a substance such as a plant, an animal or a mineral used for crude medicines, Chinese medicines, folk medicines to extract the pharmacodynamic ingredient. Furthermore, alcohol extract of Impatience balsamic L. is preferably used in an amount of 2-5 pts.wt. based on 1 pt.wt. crude medicine swollen with water.
Participants received rituximab 1000 mg intravenously (IV) on Days 1, 15, 168, and 182. They also received mycophenolate mofetil, methylprednisolone, diphenhydramine, acetaminophen, and prednisone; see the Detailed Description for details.
OBJECTIVES: We set out to predict whether nonsurgical treatment is likely to succeed in removing pancreatic stones in a given patient and also to determine an optimal maximal number of extracorporeal shock wave lithotripsy (ESWL) sessions for treatment of pancreatolithiasis in that patient.
MATERIALS AND METHODS: We ascertained the number of ESWL sessions for each of 164 patients undergoing that treatment for pancreatolithiasis between 1992 and 2020. Median follow-up duration was 31 months (range, 0-239), median age was 58 years (22-83), and the male to female ratio was 5.1:1.0. Patients were divided into 2 groups based upon an optimal maximal number of ESWL sessions determined by receiver operating characteristic analysis.
RESULTS: Total stone clearance was achieved in 130 of 164 patients (79%). The median number of ESWL sessions was 3 (1-61). Receiver operating characteristic analysis determined 7 to be the optimal maximal number of sessions. Complete clearance was more frequent (87%) among the 131 patients requiring 7 or fewer ESWL sessions than among the 33 undergoing more (48%, P < 0.001). Seventeen patients (52%) undergoing 8 or more sessions still had residual stones.
CONCLUSIONS: If any pancreatic stones persist after 7 ESWL sessions, we recommend transition to medical or surgical treatments.
The invention relates to polyethylene glycol covalent modification lysostaphin and a prepared method and application thereof. In the polyethylene glycol covalent modification lysostaphin, branching polyethylene glycol us used by the lysostaphin to modify the lysostaphin, the branching polyethylene glycol is a Y type methoxy polyethylene glycol with a signal activity function group, and the signal activity function group is arranged on an endpoint. Structural formula of the Y type methoxy polyethylene glycol with the signal activity function group is as follows. N1, n2 and n3 are respectively a positive integer which is larger than or equal to 1, and sum total of the n1, the n2 and the n3 is between 80 and 200. R is the activity function group which modifies the lysostaphin. According to the lysostaphin which is modified by polyethylene glycol, immunogenicity is reduced, activity is reduced less, half-life period is prolonged, and the lysostaphin is suitable for clinic and is applied to infection caused by staphylococcus.
The Laryngeal Tube LTS IITM (VBM-Medizintechnik GmbH, Sulz a.N, Germany) is a well established reusable latex free, extraglottic airway device. A proximal (pharyngeal) and a distal (esophageal) cuff are inflated with a single cuff pilot line. In between lies the ventilation orifice. The LMA SupremeTM (Teleflex San Diego, CA, USA) is a single use well studied laryngeal mask airway. Both devices have a drain tube to allow access to the gastrointestinal tract. Actually there are no studies comparing Laryngeal Tube LTS IITM and LMA SupremeTM use in small children. Therefore the aim of this study was to evaluate the clinical performance of the Laryngeal Tube LTS IITM compared to the LMA SupremeTM. The investigators hypothesized that design differences should lead to differences in efficacy of seal and anatomic position. In this randomized, crossover study, the investigators test the hypothesis that in non-paralyzed pediatric patients the oropharyngeal leak pressure and fiberoptic position differs between the size 2 Laryngeal Tube LTS IITM and the LMA SupremeTM.
Post-operative wound will be treated with 0.9% normal saline. Subjects will also clean the sutured wounds with normal saline twice daily then dress the wounds with petroleum jelly and a bandage.
Patients receive O6-benzylguanine IV over 1 hour, followed 1 hour later by carmustine IV over 1 hour on day 1. Treatment continues every 6 weeks for a minimum of 2 courses in the absence of disease progression or unacceptable toxicity.
The incidence of hemorrhage in clinical trials was higher on the oxaliplatin combination arm compared to the fluorouracil/leucovorin arm. These reactions included gastrointestinal bleeding, hematuria, and epistaxis. In the adjuvant treatment trial, 2 patients died from intracerebral hemorrhage [see Adverse Reactions (6.1)].

Prolonged prothrombin time and INR occasionally associated with hemorrhage have been reported in patients who received oxaliplatin with fluorouracil/leucovorin while on anticoagulants [see Adverse Reactions (6.2)]. Increase frequency of monitoring in patients who are receiving Oxaliplatin Injection with fluorouracil/leucovorin and oral anticoagulants [see Drug Interactions (7.3)].

Thrombocytopenia and immune-mediated thrombocytopenia have been observed with oxaliplatin. Rapid onset of thrombocytopenia and greater risk of bleeding have been observed in immune-mediated thrombocytopenia. In this case, consider discontinuing Oxaliplatin Injection.