anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A telemedicine system with dynamic imaging is disclosed herein. In some embodiments, the telemedicine system comprises a laser imaging and treatment apparatus, and associated systems and methods that allow a physician (e.g., a surgeon) to perform laser surgical procedures on an eye structure or a body surface with a laser imaging and treatment apparatus disposed at a first (i.e. local) location from a control system disposed at a second (i.e. remote) location, e.g., a physician's office. Also, in some embodiments, communication between the laser imaging and treatment apparatus and control system is achieved via the Internet®. Further, in some embodiments, the telemedicine system includes a dynamic imaging system and/or a facial recognition system that verifies the identity of a patient, and is capable of being used for other important applications, such as tracking and analyzing trends in a disease process.
Objective Physical inactivity and poor dietary habits plague Americans as health challenges, with women of color most vulnerable to their detrimental effects. Individually focused interventions have not demonstrated lasting success, possibly due to the lack of focus on sustainable social and physical environment factors. Health Is Power (HIP) was a transcultural, community based, randomized controlled trial that investigated the effectiveness of a group cohesion intervention to increase physical activity in African American and Hispanic or Latina women in Houston and Austin, Texas and then tested whether women living in more supportive areas maintained their physical activity over time. Intervention development was guided by group dynamics principles anchored within an ecologic model. Women participated in three health assessments and a six month face to face intervention that included evidence-based behavioral methods - integrated into strategies to promote group cohesion - framed to account for environmental factors contributing to health disparities. Women participated in team building activities, environmental mapping exercises, and supervised walks or taste tests. Neighborhood contextual and environmental measures were measured to test ecologic factors that may contribute to behavioral maintenance.
Fluconazole will be blindly administered as capsules for oral consumption. On the first day, 200 mg will be given. Subjects will then take 100 mg once daily for thirteen days.
PURPOSE:To obtain the subject composition consisting of crystalline and slightly soluble basic drug, higher fatty acid, enteric high polymer and surfactant, having no problem to stability of drug with a high reappearance and capable of providing uniformal effectiveness. CONSTITUTION:The composition consisting of (A) crystalline and slightly soluble basic drug (e.g. nicardipine) or salt thereof, (B) higher fatty acid, preferably 12 to 18C higher fatty acid which is solid at ordinary temperature and 0.3 to 16 times by weight based on the ingredient A, (C) enteric high polymer, e.g. methacrylic acid-(meth)acrylic acid ester copolymer 0.3 to 16 times by weight based on the ingredient A and (D) surfactant, preferably nonionic surfactant 0.002 to 2 times by weight based on the ingredient A. Blend ratio of the ingredient A is 5 to 50wt.%, preferably 10 to 30wt.%. The abovementioned four ingredients are kneaded in prescribed weight ratio, pulverized and uniformed to prepare the abovementioned composition.
Cases of severe hepatic toxicity, including fulminant hepatic necrosis have occurred in patients who have substituted sustained-release (modified-release, timed-release) nicotinic acid products for immediate-release (crystalline) nicotinic acid at equivalent doses.

Liver function tests should be performed on all patients during therapy with nicotinic acid. Serum transaminase levels, including ALT (SGPT), should be monitored before treatment begins, every six weeks to twelve weeks for the first year, and periodically thereafter (e.g., at approximately 6 month intervals). Special attention should be paid to patients who develop elevated serum transaminase levels, and in these patients, measurements should be repeated promptly and then performed more frequently. If the transaminase levels show evidence of progression, particularly if they rise to three times the upper limit of normal and are persistent, the drug should be discontinued. Liver biopsy should be considered if elevations persist beyond discontinuation of the drug.

Nicotinic acid should be used with caution in patients who consume substantial quantities of alcohol and/or have a past history of liver disease. Active liver diseases or unexplained transaminase elevations are contraindications to the use of nicotinic acid.
FIELD: medicine; gastroenterology. SUBSTANCE: patient's stomach subjected to lavage through duodenal probe using irrigating fluid containing medicinal agents. Probe comprises hollow olive having 16 openings with 1 mm dia. Openings are uniformly scattered all over olive surface. Duodenal probe olive accommodates concave plate occupying 2/3 of olive lumen and arranged do that concavity apex faces tube. Next stomach mucosa is irrigated with fluid having temperature 39-40 C and fed under pressure 40 mm Hg, irrigation being effected daily for 7-10 days. EFFECT: effective treatment for erosive gastritis cases. 1 tbl
The outbreak of emerging infectious diseases gave rise to the demand for reliable point-of-care testing methods to diagnose and manage those diseases in early onset. However, the current on-site testing methods including lateral flow immunoassay (LFIA) suffer from the inaccurate diagnostic result due to the low sensitivity. Herein, we present the surface-enhanced Raman scattering-based lateral flow immunoassay (SERS-LFIA) by introducing phage-templated hierarchical plasmonic assembly (PHPA) nanoprobes to diagnose a contagious disease. The PHPA was fabricated using gold nanoparticles (AuNPs) assembled on bacteriophage MS2, where inter-particle gap sizes can be adjusted by pH-induced morphological alteration of MS2 coat proteins to provide the maximum SERS amplification efficiency via plasmon coupling. The plasmonic probes based on the PHPA produce strong and reproducible SERS signal that leads to sensitive and reliable diagnostic results in SERS-LFIA. The developed SERS-LFIA targeting severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) antibodies for a proof of concept had <100 pg/mL detection limits with high specificity in serum, proving it as an effective diagnostic device for the infectious diseases. Clinical validation using human serum samples further confirmed that the PHPA-based SERS-LFIA can distinguish the patients with COVID-19 from healthy controls with significant accuracy. These outcomes prove that the developed SERS-LFIA biosensor can be an alternative point-of-care testing (POCT) method against the emerging infectious diseases, in combination with the commercially available portable Raman devices.
Psychosocial and mental health problems is a growing public health concern and challenge for primary care where resources are scarce. The multi-professional novel service delivery model "Primary Care Behavioural Health" (PCBH) has been suggested as an effective way to integrate behavioural health services into routine primary care. The model offer high accessibility to brief interventions, is clinically intuitively attractive and has been disseminated in primary care organizations globally, as well as in Sweden. However, more research is needed on its effect and implementation in routine care. The objective is to investigate the effect of the new service delivery model PCBH on organization- staff- and patient outcomes, and to investigate the implementation of PCBH in terms of how and to which degree the new way of working is normalised in practice routines. This multicenter mixed-methods interventional study is designed as a controlled pragmatic clinical trial. The effect of PCBH will be investigated on organizational, staff and patient levels. Variables include waiting lists, symptoms, medication prescriptions, quality of life and working environment aspects. Study participants will be patients, staff and managers at the included primary care centers. Implementation of PCBH will be investigated regarding the implementation process and degree of implementation. Data will be both qualitative (individual interviews) and quantitative (registers, biomarkers and questionnaires). At least 24 intervention centers will be compared to an equal number of control centers. The research project will be conducted in several regions in Sweden during a period of 4 years. PCBH seems to offer a solution the challenges in modern primary care, but evidence is low. This study will provide much-needed clinically meaningful data regarding PCBH that hopefully could be used for future development of primary healthcare.
New methods for diagnosis and treatment of human dormancy syndrome-related sequellae are provided. Human dormancy syndrome (HDS) is characterized by elevated serum ratio of rT3/fT3 compared to a population of normal subjects. HDS includes fibromyalgia, chronic fatigue, cancer, autoimmune disease, obesity and related dormancy conditions. Dormancy and HDS-related sequellae are imposed on humans by infection with lipopolysaccharide (LPS; or endotoxin)-producing organisms, especially those that are intracellular and those that create antigens that stimulate the TLR pathways. In such instances, the elimination or neutralization of the LPS signal along with the infectious source is required to impact the sequellae of HDS. Treatment includes use of novel and non-obvious doses of antibiotics, optionally including agents that decrease the adverse effects of endotoxin.
The invention relates to a water lily lozenge for blood pressure reduction. Raw materials used in the invention mainly comprise water lily flower, water lily seed, wild chrysanthemum, Spica Prunellae, cassia seed, xylitol, maltodextrin, citric acid, magnesium stearate and Laoshan mineral water, and the lozenge is prepared through a special process. High blood pressure, high blood sugar and fatty liver are epidemic diseases at present. Blood pressure reduction drugs in the current market have the disadvantages of convenient administration and inconvenient carrying. The water lily lozenge for blood pressure reduction integrates the efficacies of a variety of Chinese herbal medicines with blood pressure reduction activity, is prepared from pure natural Chinese herbal medicines, has very good blood pressure reduction preventing and assisting effects, is simple to eat, and is convenient to carry. The lozenge adopting xylitol to substitute sucrose is suitable for more people, and is especially suitable for elevated blood pressure people to administrate.
Addiction is a primary, chronic, neurobiologic disease, with genetic, psychosocial, and environmental factors influencing its development and manifestations. It is characterized by behaviors that include one or more of the following: impaired control over drug use, compulsive use, continued use despite harm, and craving. Drug addiction is a treatable disease, utilizing a multidisciplinary approach, but relapse is common.

Concerns about abuse and addiction should not prevent the proper management of pain. However, all patients treated with opioids require careful monitoring for signs of abuse and addiction, because use of opioid analgesic products carries the risk of addiction even under appropriate medical use.

"Drug seeking" behavior is very common in addicts, and drug abusers. Drug-seeking tactics include emergency calls or visits near the end of office hours, refusal to undergo appropriate examination, testing or referral, repeated claims of loss of prescriptions, tampering with prescriptions and reluctance to provide prior medical records or contact information for other treating physician(s). "Doctor shopping" (visiting multiple prescribers) to obtain additional prescriptions is common among drug abusers and people suffering from untreated addiction. Preoccupation with achieving adequate pain relief can be appropriate behavior in a patient with poor pain control.

Abuse and addiction are separate and distinct from physical dependence and tolerance. Physicians should be aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. In addition, abuse of mu-opioid agonists can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances. Careful recordkeeping of prescribing information, including quantity, frequency, and renewal requests is strongly advised.

Abuse of NUCYNTA® poses a risk of overdose and death. This risk is increased with concurrent abuse of NUCYNTA® with alcohol and other substances. In addition, parenteral drug abuse is commonly associated with transmission of infectious diseases such as hepatitis and HIV.

Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of drugs with mu-opioid agonist properties.

Infants born to mothers physically dependent on opioids will also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms [see Warnings and Precautions (5.1)]. Use of NUCYNTA® in this population has not been characterized. As NUCYNTA® has mu-opioid agonist activity, infants whose mothers have taken NUCYNTA®, should be carefully monitored.
The invention provides Chinese medicine preparation for external use for treating rheumatism and rheumatoid disease and the preparation method thereof. The preparation is prepared by using large leaf gentian roots, Chinese clematis, gum mastic, myrrh, momordica cochinchinensis(Lour.) spreng, castor seeds, and sesame oil. The gum mastic and the myrrh are pulverized into fine powder, the large leaf gentian roots are boiled by adding water, and plaster is obtained after filter liquor is decompressed and concentrated. The Chinese clematis is soaked in the sesame oil, the momordica cochinchinensis(Lour.) spreng and the castor seeds are soaked in the obtained medical oil, and then beaten to be slurry, beeswax is added into the obtained medical oil for melting, then the fine powder, the plaster, the slurry and the medical oil are mixed evenly, and various preparation formulations are produced according to conventional preparation craft. Compared with the prior art, the invention uses the common Chinese medicines as the raw materials, the used raw materials are in a small variety, the product quality is easy to be controlled, the effective components of the raw material medicines are obtained after extraction, to be more easily absorbed and to exert the drug efficacy, thereby providing a medicine for external use for treating rheumatism and rheumatoid disease with low administration cost and good curative effect.
PURPOSE:To provide a slow-releasing drug preparation containing a porous powder of deacetylated chitin as a carrier of a drug component, and having mitigated side effects and improved durability of the drug action. CONSTITUTION:The objective slow-releasing agent is produced by using a porous granule of deacetylated chitin as a carrier, and impregnating a physiologically active substance (e.g. carcinostatic agent, hormonic agent, etc.) therein. The deacetylated chitin is obtained by deacetylating a chitin having a chemical structure of poly-N-acetylglucosamine to amino group, and its deacetylation degree (DA) is 0<DA<100%. The product is suitable as an adsorption carrier for medicinal drug. The deacetylated chitin is infested by the macrophage activated by the intracutaneous injection or embedding of the preparation and the circumference of the remaining aminoacetyl group is hydrolyzed by lysozyme to effect the slow release of the drug component.
FIELD: medicine, organic technology. SUBSTANCE: 2,3-dihydro-1,4-benzodioxine-5-yl-pyperazine derivatives have formula I   wherein R 1  is halogen, lower alkyl or alkoxyl, hydroxyl or cyan group, m=1 or 2, n=0 or 1. A is alkylene chain comprising 2-6 carbon atoms which may be substituted by one or two lowers alkyl groups or by one phenyl group. B is methylene, ethylene, carbonyl, sulfunyl, sulfonyl or sulfur. Proposed compounds or salts thereof posses 5-HT 1A -antagonist activity. EFFECT: improved quality of product. 1 tbl
The "Top-Down" HoLEP technique is a novel technique which offers potential benefits to the Traditional HoLEP procedure, including decreased complexity, a reduced learning curve, with anticipated improved continence \[8\]. A variation of this method is also being explored in Japan (termed the "en-bloc technique with anteroposterior dissection HoLEP") \[9\]. The main difference between the Top-Down and Traditional approach is that the direction of lateral dissection begins from upwards to downwards. This could help in avoiding the overtraction of the mucosal strip overlying the posterior urethral sphincter, which theoretically leads to a decrease in the incidence of postoperative stress incontinence. Moreover, using the Top-Down approach should lead to a decrease in the incidence of lost enucleation planes, which results in decreasing the intraoperative time and decreasing the number of cases required to master the HoLEP technique.
QUDEXY XR can cause fetal harm when administered to a pregnant woman. Data from pregnancy registries indicate that infants exposed to topiramate in uterohave an increased risk of major congenital malformation, including but not limited to cleft lip and/or cleft palate (oral clefts), and of being small for gestational age (SGA). When multiple species of pregnant animals received topiramate at clinically relevant doses, structural malformations, including craniofacial defects, and reduced fetal weights occurred in offspring [see Use in Specific Populations (8.1)] . 

Consider the benefits and risks of QUDEXY XR when administering this drug in women of childbearing potential, particularly when QUDEXY XR is considered for a condition not usually associated with permanent injury or death [see Use in Specific Populations (8.1), Patient Counseling Information (17)] . QUDEXY XR should be used during pregnancy only if the potential benefit outweighs the potential risk. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be informed of the potential hazard to a fetus [see Use in Specific Populations (8.1)] .
Vaccine adjuvants, for use as vehicles for administration of injectable immunalogical substances, comprise a water-in-oil emulsion consisting on a volume basis of 20 to 75% of vegetable oil; 1.25 to 25% of mannide mono-oleate; 0.5 to 5% of aluminium monostearate, and sufficient aqueous phase to bring the volume to 100%.  The emulsion is prepared by mixing the oil and mannide mono-oleate portion wise, adding the aluminium salt, and heating with simultaneous mixing, until the aluminium salt is dispersed and thixotropy sets in; the solution is then cooled to room temperature, and the aqueous phase added in portions, with suitable mechanical emulsification. Preferred oils are peanut, sesame, chaulmoogra, corn, alive, cottonseed, sweet almond, or persic oils.  A further emulsifying agent (e.g. Polysorbate 80) may be included.  The vaccine, preferably a purified or partially purified antigen, is added to the aqueous phase before addition of the latter to the oil phase.  The aqueous phase may be for example, water, suitable saline solution, phosphate buffered saline, or tissue culture fluid, and may contain preservatives or other conventional vaccine additives.  Antigens specified are those derived from bacteria, viruses, rickettsia, pollen, dust, danders, poisons or venoms of insects or reptiles, or multiple (mixed) antigens.ALSO:The invention comprises a water-in-oil emulsion, comprising, on a volume basis: 20 to 75% vegetable oil; 1.25 to 25% of mannide mono-oleate; 0.5 to 5% of aluminium monostearate, and sufficient aqueous phase to bring the volume to 100%.  The composition is prepared by mixing the vegetable oil and the mannide mono-oleate, combining the mixture with the aluminium monostearate, followed by slow heating of the resulting product with mixing to a temperature where the aluminium salt is dispersed, and thixotropy sets in.  The solution is then cooled to room temperature and the aqueous phase added in portions with emulsification by suitable mechanical means.  Optionally a secondary emulsifying agent (e.g. polysorbate 80) may be included.  Preferred vegetable oils are peanut, sesame, corn, olive, cottonseed, sweet almond, persic, and chaulmoogra oils.  The emulsion is for use as an adjurant for injectable inmunological substances (see Division A5).
Abnormal relaxation and contraction of intestinal smooth muscle can cause various intestinal diseases. Diarrhea is a common and important public health problem worldwide in epidemiology. Zingiber officinale Roscoe (fresh ginger) has been found to treat diarrhea, but the material basis and mechanism of action that inhibits intestinal peristalsis remain unclear. Metabolomics and serum pharmacology were used to identify differential metabolites, metabolic pathways, and pharmacodynamic substances, and were then combined with network pharmacology to explore the potential targets of ginger that inhibit intestinal peristalsis during diarrhea treatment, and the targets identified were verified using molecular docking and molecular dynamic simulation. We found that 25 active components of ginger (the six most relevant components), 35 potential key targets (three core targets), 40 differential metabolites (four key metabolites), and four major metabolic pathways were involved in the process by which ginger inhibits intestinal peristalsis during diarrhea treatment. This study reveals the complex mechanism of action and pharmacodynamic material basis of ginger in the inhibition of intestinal peristalsis, and this information helps in the development of new Chinese medicine to treat diarrhea and lays the foundation for the clinical application of ginger.
BACKGROUND: Endometrial cancer (EC) presents significant clinical challenges due to its heterogeneity and complex pathophysiology. SAMHD1, known for its role as a deoxynucleotide triphosphate triphosphohydrolase, has been implicated in the progression of various cancers, including EC. This study focuses on elucidating the role of SAMHD1 in EC through its impact on TRIM27-mediated PTEN ubiquitination.
RESULTS: Utilizing a combination of bioinformatics and cellular biology techniques, we investigated the interactions among SAMHD1, TRIM27, and PTEN. Our findings reveal that SAMHD1 modulates PTEN ubiquitination via TRIM27, impacting key pathways involved in EC pathogenesis. These interactions suggest a critical mechanism by which SAMHD1 could influence tumor behavior and progression in EC.
CONCLUSIONS: The results from this study underscore the potential of targeting the SAMHD1-TRIM27-PTEN axis as a therapeutic strategy in EC. By providing new insights into the molecular mechanisms underlying EC progression, our research supports the development of novel therapeutic approaches that could contribute to improve treatment strategies for patients with EC.
PURPOSE: A composition containing Allium tuberosum rottl. juice freeze-dried material and processed sulfur is provided to prevent or treat obesity and to lower liver function. CONSTITUTION: A composition for preventing and treating arteroslcerosis contains 5-20 wt% of fermented Allium tuberosum rottl. juice freeze-dried material and 0.01-0.2 wt% of processed sulfur. The composition enhanced HDL-cholesterol level and lowers LDL-cholesterol level in serum. A health function food for preventing and treating arteroslcerosis contains the freeze-dried material and processed sulfur.