anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a house-fly pupa natural antibiotic peptide product as well as a preparation method and application thereof; house-fly pupas, the raw material of the antibiotic peptide product, are extracted overnight by acid and hot-processed to collect supernatant; and after going through siever filtration and ultrafiltration precessing, the supernatant is treated with spray dring to obtain the antibiotic peptide product. The preparation technique of the antibiotic peptide product is simple and quick, the yield of the antibiotic peptide reaches 1.2 percent and the recovery rate of the antibacterial activity is over 80 percent. The prepared house-fly antibiotic product consists of peptides which have the molecular weight less than 20kDa and are mainly micromolecular peptides with the molecular weight less than 14.4 kDa. The antibiotic peptide product has broad-spectrum antibiotic activity and no hemolytic activity to blood erythrocytes of mice and is characterized by high temperature resistance, acid and alkali resistance and good stability. The byproducts of the technique can serve as feeding insect protein powder. The prepared antibiotic peptide product can be widely applied to the fields such as the antisepsis and storage of foods, fruits and vegetables, feed additives, cosmetic and the like.
PURPOSE:To provide the subject base-coating agent containing a water-based polymer emulsion and effective in preventing the discoloration of nail by applying to the surface of nail prior to the application of a nitrocellulose-based nail enamel. CONSTITUTION:The objective base-coating agent for nitrocellulose-based nail enamel contains 5-60wt.% (in terms of solid) of a water-based polymer emulsion. The water-based polymer emulsion is preferably a cationic emulsion, which can be produced by adding water to an organic solvent solution (preferably methyl ethyl ketone solution) of a copolymer derived from 2-10wt.% of a monomer having a basic nitrogen atom and a double bond (e.g. N,N- dimethylaminoethyl acrylate) and 90-98wt.% of a hydrophobic monomer having a double bond (e.g. methyl acrylate) and distilling off the organic solvent. The base-coating agent has high film-forming property and film strength, and gives a coating film having excellent water-resistance.
Experience in patients taking very high doses of pantoprazole sodium (greater than 240 mg) is limited. Spontaneous post-marketing reports of overdose are generally within the known safety profile of pantoprazole sodium.   
Pantoprazole is not removed by hemodialysis. In case of overdosage, treatment should be symptomatic and supportive.   
Single oral doses of pantoprazole at 709 mg/kg, 798 mg/kg, and 887 mg/kg were lethal to mice, rats, and dogs, respectively. The symptoms of acute toxicity were hypoactivity, ataxia, hunched sitting, limb-splay, lateral position, segregation, absence of ear reflex, and tremor.
INTRODUCTION: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) score is widely used for evaluating the health status of patients diagnosed with COPD. The aim of this study was to identify which components of the CAT are associated with exacerbations in severe COPD patients.
METHODS: Using data from the Korean COPD Subgroup Study (KOCOSS), we identified 3,440 COPD patients, among which 1,027 patients are classified as having severe COPD based on spirometry results. The CAT scores on 8 items were evaluated and classified into respiratory and non-respiratory categories. We analyzed the association between CAT item scores and moderate-to-severe exacerbations during study enrollment and the following years.
RESULTS: Patients with a history of moderate-to-severe exacerbations had higher scores on non-respiratory CAT components. Longitudinal CAT scores on all items after enrollment were higher in the moderate-to-severe exacerbation group. Additionally, the frequency of severe exacerbations was associated with specific CAT components related to limited activities, confidence leaving home, sleeplessness, and energy.
CONCLUSIONS: This study revealed that the non-respiratory CAT component scores were statistically significant factors for predicting the moderate-to-severe exacerbation of severe COPD patients. Non-respiratory symptoms and functional limitations should be considered in patients with severe COPD. Interventions, such as pulmonary rehabilitation, may be needed to improve patients' overall well-being and prevent exacerbations.
Long COVID is a term used to describe the long-terms effects of COVID-19 infection that continue for weeks or months after the patient has recovered from COVID-19. Long COVID is defined by the persistence of symptoms beyond 12 weeks from the onset of the disease. Corticosteroids are part of the treatment in this period with good results in controlling the disease; however, it is a predisposing factor for the development of avascular necrosis. We present a clinic case of a young man of 39 years old with diagnosis of avascular necrosis in his left hip, before the administration of corticosteroids for the treatment of COVID-19. There is a lack of consensus about the dosage and duration of steroids required to develop avascular necrosis. Some authors have reported that cumulative dose of 2,000 mg prednisone (or its equivalent) was required for avascular necrosis development. For patients with advanced avascular necrosis stages total hip arthroplasty is an attractive option with excellent outcomes in terms of pain relief and survivorship.
Participants receive gebasaxturev at a dose of 1 X 10\^9 TCID50 by IV infusion on Days 1, 3, 5, and 8 of Cycle 1 (28-day cycle) and Day 1 of Cycles 2-8 (21-day cycles) plus pembrolizumab 200 mg by IV infusion on Day 8 of Cycle 1 (28-day cycle) and Day 1 of each subsequent 21-day cycle. Gebasaxturev will be administered for up to 8 cycles (up to 6 months). Pembrolizumab will be administered for up to 35 cycles (up to 2 years).
Identification of the predictors of cognitive impairment and cognitive resilience among aging women is important because the incidence of mild cognitive impairment (MCI) and dementia increases with age and women live the longest. The Women's Health Initiative Memory Study examined the impact of randomization to hormone therapy (conjugated equine estrogen alone or in combination with medroxyprogesterone vs. placebo) in a subset of participants aged 65-79 years at enrollment into WHI and the WHI Hormone Trials. WHIMS revealed an increased risk of all-cause dementia and MCI plus poorer global cognitive function among women randomized to HT compared to those receiving placebo. WHIMS ECHO is a prospective, observational study of the remaining cohort of WHIMS participants following cessation of treatment. Annual cognitive assessments of learning, attention, memory, working memory, executive function and language are conducted by telephone by trained staff and adjudication of incident cognitive impairment (MCI and dementia) continues. This enables the continued monitoring of long-term effects of randomization to HT on cognition and identification of predictors of cognitive aging and resilience in older women.
A chaperone protein Q2 and ~-amyloid can form a complex. This complex can be detected in a biological sample, such as, for example, tissues or fluids from a mammal. Q2 levels can also be detected in a biological sample. A method for determining the Q2 level in a biological sample and comparing that level to a normal Q2 level can be used to detect, screen, diagnose, or otherwise determine a person's susceptibility to Alzheimer's disease such as, for example, the presence or absence of Alzheimer's disease, of symptoms of this disease, of factors leading to or associated with this disease, of likelihood of developing this disease, and the like. In one embodiment, a decline in Q2 level correlates to an increased likelihood of developing Alzheimer's disease. In another embodiment, a decline in Q2 level correlates to an increase in ~-amyloid aggregation. The method may further include screening for an apolipoprotein E genetype, which is associated with Alzheimer's disease.
Cabozantinib is available in capsule form. The dose is 60 mg daily by mouth. Subjects with disease progression at 6 weeks who do not have significant toxicities may remain on therapy for an additional six weeks until a progression is confirmed. Further study drug administration beyond 12 weeks will be at the discretion of the investigator provided that the subject does not have disease progression, does not have unacceptable side effects, does not withdraw from study, or does not have a medical condition or illness that renders the subject unacceptable to receive further study drug.
INTRODUCTION: Cells are covered with a glycan surface layer that is referred to as the glycocalyx (GCX). It has been reported that the formation of the GCX is promoted on cancer cells and is associated with tumor growth and metastasis. Heparan sulfate proteoglycan glypican-1 (GPC1) is a core protein of the GCX that is overexpressed in esophageal squamous cell carcinoma (ESCC) and is involved in the development and progression of cancer cells. The purpose of the present study is to analyze the utility of GPC1 as a new biomarker ralated to glycocalyx that reflects therapeutic effect and prognosis of ESCC.
METHODS: We measured the concentration of GPC1 protein in preoperative plasma from advanced esophageal cancer patients and examined its relationships with clinicopathological factors and therapeutic efficacy, and the effects of extracellular GPC1 were investigated.
RESULTS: The following clinical factors were significantly correlated with the preoperative high GPC1 concentration: male, tumor size ≥30 mm, venous invasion, pT factor ≥2, pStage ≥3, residual tumor, and distant metastatic recurrence. Both overall and recurrence-free survival were significantly worse in the high GPC1 group. Extracellular GPC1 protein concentration reflected intracellular GPC1 expression. Furthermore, we examined the effects of extracellular recombinant human (rh)GPC1 on ESCC cells, and found that extracellular rhGPC1 affects cell motility, including migration and invasion.
CONCLUSIONS: These results demonstrated the utility of extracellular GPC1 as a biomarker, which can be assayed from a less invasive blood sample-based liquid biopsy. Extracellular GPC1 protein plays a role in both tumor cell motility and cancer progression. Thus, plasma GPC1 is a useful biomarker for esophageal cancer progression and may be a potential candidate of therapeutic target.
To minimize changes of a medical treatment report input scheme and facilitate utilization of medical treatment reports.SOLUTION: A medical treatment assist device pertaining to an embodiment comprises an acquisition unit, an analysis unit, a first generation unit, a second generation unit and a display control unit. The acquisition unit acquires medical ontology and input data having been inputted in natural language form to the free description column of a medical treatment report. The analysis unit executes natural language processing on the input data and thereby generates the analysis data of the input data. The first generation unit generates structured data in which medical ontology is associated with the analysis data. The second generation unit generates confirmation data in which the structured data is displayed in natural language form. The display control unit causes the confirmation data to be displayed by a display.SELECTED DRAWING: Figure 1
PURPOSE:To obtain PS antibody sensitized blood cells by conjugating anticandida polysaccharide antibody (PS antibody) via a coupling agent with red blood cells. CONSTITUTION:The red blood cells to be used for sensitized blood cells are preferably fixed red blood cells in terms of preservation and are formed by treating the raw red blood cells suspended by an alsever liquid with gaseous carbon monoxide and adding formalin thereto to fix the cells. A tannic acid, etc. are used for a coupling agent. The bacteria for candida are obtd. by inoculating the same in the Sabouraud's broth, etc. and culturing the same at about 37 deg.C. The anticandida bacterium antibody is obtd. of the bacteria killed by a heating treatment, etc. and are immunized with a rabbit, etc. A polysaccharide antigen is then mixed with the anticandida antibody and the precipitate of only the immune complex is made. The precipitate is centrifugally dispensed and an acetic acid buffer soln. is added thereto, to which a satd. ammonium sulfate soln. is added to settle the antibody. The PS antibody is refined by centrifugal sepn., dialysis, etc. The red blood cells are treated by using the coupling agent and the liquid contg. the PS antibody is brought into contact therewith, by which the PS antibody sensitized red blood cells are obtd.
PURPOSE: A collagen originated from pollack and cuttlefish skin is provided to have an effect of making cuttlefish and Pollack skin into resources, and to have an excellent effect of providing a cosmetic composition having a high absorption rate. CONSTITUTION: A method of manufacturing a collagen comprises the steps of enzymolysis of fish byproducts. The enzyme is one between Alcalase and Neutrase. The fish byproduct is cuttlefish skin or Pollack skin. Collagen powder is manufactured by the method. A cosmetic composition comprises the collagen powder as an active ingredient.
PURPOSE: A composition for prevention or treatment of brain disorder or viral diseases including a DRG2 inhibitor is provided to interrupt protein expression and activities or excessive expressing DRG2 gene in disease cells related to the viral disease or the brain disorder, thereby preventing protein condensation. CONSTITUTION: A composition for prevention or treatment of brain disorder or viral diseases comprises an expression inhibitor of the DRG 2 and developmentally regulated GTP-binding protein 2. The DRG2 gene is composed of the base sequence having the sequence number 1(SEQ ID NO:1). The expression inhibitor of the DRG2 gene is the anti-sense oligonucleotide for a gene marked by the sequence number 1, siRNA or shRNA. The expression inhibitor of the DRG2 gene has a coherence inhibition activity of the brain disorder induction protein or virus growth control activities. The viral disease is influenza, coiling, human immunodeficiency virus(HIV), herpes simplex, shingles, molluscum contagiosum, chicken pox, warts or hand-foot-and-mouth disease. A method for screening the material for preventing or treating the viral disease or the brain disorder comprises the following steps: contacting the sample for analyzing with the cell which includes the DRG2 gene or the DRG2 protein; measuring the amount of the DRG2 gene expression, amount of the DRG2 protein, and activities of the DRG2 protein; and judging the sample as the material for prevention or treatment of the viral diseases or the brain disorder in case the amount of the DRG2 gene expression, amount of the DRG2 protein, and activities of the DRG2 protein are decreased.
BACKGROUND: Total hip replacement is routinely recommended for severe hip osteoarthritis, but data from randomized trials are lacking regarding comparison of the effectiveness of this procedure with that of nonsurgical treatment such as resistance training.
METHODS: We conducted a multicenter, randomized, controlled trial to compare total hip replacement with resistance training in patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery. The primary outcome was the change in patient-reported hip pain and function from baseline to 6 months after the initiation of treatment, assessed with the use of the Oxford Hip Score (range, 0 to 48, with higher scores indicating less pain and better function). Safety was also assessed.
RESULTS: A total of 109 patients (mean age, 67.6 years) were randomly assigned to total hip replacement (53 patients) or resistance training (56 patients). In an intention-to-treat analysis, the mean increase (indicating improvement) in the Oxford Hip Score was 15.9 points in patients assigned to total hip replacement and 4.5 points in patients assigned to resistance training (difference, 11.4 points; 95% confidence interval, 8.9 to 14.0; P<0.001). At 6 months, 5 patients (9%) who had been assigned to total hip replacement had not undergone surgery, and 12 patients (21%) who had been assigned to resistance training had undergone total hip replacement. The incidence of serious adverse events at 6 months was similar in the two groups; the majority of such events were known complications of total hip replacement.
CONCLUSIONS: In patients 50 years of age or older who had severe hip osteoarthritis and an indication for surgery, total hip replacement resulted in a clinically important, superior reduction in hip pain and improved hip function, as reported by patients, at 6 months as compared with resistance training. (Funded by the Danish Rheumatism Association and others; PROHIP ClinicalTrials.gov number, NCT04070027.).
<P>PROBLEM TO BE SOLVED: To provide a cosmetic material with excellent design or a cosmetic product with the cosmetic material stored in a container by decorating the cosmetic material or the cosmetic product with the cosmetic material stored in the container with illumination of light.  <P>SOLUTION: A method of decorating the cosmetic material is to illuminate the translucent cosmetic material with light, by which the translucent cosmetic material is made to shine and decorated. The method of decorating the cosmetic product with the translucent cosmetic material stored in a container is to illuminate the translucent cosmetic material with light, by which the translucent cosmetic material is made to shine to decorate the cosmetic product. The method of decorating the cosmetic product is characterized by the illumination of light from a light emitter mounted in the container. Further, the cosmetic product with the light emitter in the container decorated by the method is also provided.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Treatment of 21 individuals in the Myofascial Release group will be done by the researcher. Among the conservative treatment methods, hot pack(15 minutes) around the glenohumeral joint, conventional TENS(15 minutes) for painful points, ultrasound(1.5 watt / cm² power, 5 minutes),exercise(passive and active range of motion) and myofascial release to subscapularis and serratus anterior muscles approaches will be applied. Individuals will be asked to come to the center where the research will be conducted for a total of fifteen sessions for three weeks, five times a week. Myofascial release will be done in the first five sessions of treatment programs.
While it is widely thought that de novo mutations (DNMs) occur randomly, we previously showed that some DNMs are enriched because they are positively selected in the testes of aging men. These "selfish" mutations cause disorders with a shared presentation of features, including exclusive paternal origin, significant increase of the father's age, and high apparent germline mutation rate. To date, all known selfish mutations cluster within the components of the RTK-RAS-MAPK signaling pathway, a critical modulator of testicular homeostasis. Here, we demonstrate the selfish nature of the SMAD4 DNMs causing Myhre syndrome (MYHRS). By analyzing 16 informative trios, we show that MYHRS-causing DNMs originated on the paternally derived allele in all cases. We document a statistically significant epidemiological paternal age effect of 6.3 years excess for fathers of MYHRS probands. We developed an ultra-sensitive assay to quantify spontaneous MYHRS-causing SMAD4 variants in sperm and show that pathogenic variants at codon 500 are found at elevated level in sperm of most men and exhibit a strong positive correlation with donor's age, indicative of a high apparent germline mutation rate. Finally, we performed in vitro assays to validate the peculiar functional behavior of the clonally selected DNMs and explored the basis of the pathophysiology of the different SMAD4 sperm-enriched variants. Taken together, these data provide compelling evidence that SMAD4, a gene operating outside the canonical RAS-MAPK signaling pathway, is associated with selfish spermatogonial selection and raises the possibility that other genes/pathways are under positive selection in the aging human testis.
The effectiveness of static stretching on various parameters such as range of motion or pain is studied and proved in literature. Static stretching in cross body position was also found helpful for improving shoulder range of motion with some disadvantages. In modified cross body position, the patient is positioned in a more advantageous way for him/her. Usually this stretching is done as active-assistive static stretching with the physiotherapist. Proof is still needed for the effectiveness of active-assistive static stretching in modified cross body position. Furthermore, there is no research about the effect of isolytic stretching which is relatively new technique compare to static stretches in subacromial impingement syndrome. In isolytic stretching, when the patient contracts the agonist muscle group with 20% muscle force active-assistive streching in agonist muscle group by the physiotherapist at the same time is done for 2-4 seconds. A fast isolytic stretching is applied in order to break the fibrous tissue. Our purpose is to investigate and compare the effect of isolytic and static stretching training in individuals having subacromial impingement syndrome with glenohumeral internal rotation deficit . Stretching groups will receive either isolytic or static stretching in modified cross body stretching position and standard physiotherapy program. There is a control group. Control group will receive only standard physiotherapy program. Standard physiotherapy program includes TENS, hotpack, posture and strengthening training program. Treatment program will last four times a week (4-4-4-3) for four weeks, 15 sessions in total.
<P>PROBLEM TO BE SOLVED: To provide an impregnation sheet for uniformly applying a thixotropic base agent to a treating surface.  <P>SOLUTION: The impregnation sheet has a 1st fiber layer 1 containing non-shrinkable fibers and a 2nd fiber layer 2 placed adjacent to the 1st layer and containing heat-shrunk fibers. Both fiber layers are partly integrated in thickness direction through a number of junction parts 3 and the 1st fiber layer 1 is protruded between the junction parts 3 by the heat-shrinkage of the 2nd fiber layer 2 to form a number of protrusions 4. A thixotropic agent is impregnated in the obtained steric nonwoven fabric 10. The sheet is used by contacting the 1st fiber layer 1 with the treating surface.  <P>COPYRIGHT: (C)2004,JPO