anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
METHODS: The study employed a retrospective survey of 458 older individuals with T2D residing in a Chinese community, conducted between June 2020 and May 2021, to develop a predictive model for frailty. Among the participants, 83 individuals (18.1%) were diagnosed with frailty using modified frailty phenotypic criteria. The predictors of frailty in this community-dwelling older population with T2D were determined using least absolute shrinkage and selection operator (LASSO) regression and multivariable logistic regression. These predictors were utilized to construct a nomogram. The discrimination, calibration, and medical usefulness of the prediction model were assessed through the C-index, calibration plot, and decision curve analysis (DCA), respectively. Additionally, internal validation of the prediction model was conducted using bootstrapping validation.
RESULTS: The developed nomogram for frailty prediction predominantly incorporated age, smoking status, regular exercise, depression, albumin (ALB) levels, sleep condition, HbA1c, and polypharmacy as significant predictors. Our prediction model demonstrated excellent discrimination and calibration, as evidenced by a C-index of 0.768 (95% CI, 0.714-0.822) and strong calibration. Internal validation yielded a C-index of 0.732, further confirming the reliability of the model. DCA indicated the utility of the nomogram in identifying frailty among the studied population.
CONCLUSION: The development of a predictive model enables a valuable estimation of frailty among community-dwelling older individuals with type 2 diabetes. This evidence-based tool provides crucial guidance to community healthcare professionals in implementing timely preventive measures to mitigate the occurrence of frailty in high-risk patients. By identifying established predictors of frailty, interventions and resources can be appropriately targeted, promoting better overall health outcomes and improved quality of life in this vulnerable population.
Twenty patients will be voluntarily enrolled in two groups: 10 healthy participants, and 10 participants with peri-implantitis. Periodontal and peri-implant clinical and radiographic measurements, as well as body mass index, medical and dental history will be recorded within the following timelines: at baseline (for both groups), and 6 months after baseline for the peri-implantitis group only. At baseline, gingival biopsies and blood will be harvested from: a) healthy gingival sites during either surgical removal of wisdom teeth or gingivoplasty, in the healthy group; and, b) from a peri-implantitis site during surgical treatment of peri-implantitis, and when possible, from a healthy gingival site within the same participant, in the peri-implantitis group. After harvesting of biopsies, peri-implantitis subjects will be re-evaluated 6 months after treatment. During the 6-month visit, if a second surgical treatment of peri-implantitis in the same implant treated at baseline is indicated as standard of care of the participant, a new gingiva biopsy and blood will be collected. Gingival biopsies and blood collected from each participant will be used to perform DNA methylation analysis.
PURPOSE: A promoter of neurite outgrowth containing a Cordyceps Militaris extract is provided to promote formation, elongation, and branching of neurites, thereby promoting neurite outgrowth. CONSTITUTION: A composition for promoting neurite outgrowth contains a Cordyceps Militaris extract. A composition for preventing or treating neurodegenerative diseases contains the extract. The extract is prepared using water, C1-C4 alcohols, or a mixture thereof. The extract induces sprouting, elongation, and branching of neurites. The extract promotes the expression of choline acetyltransferase.
The invention discloses a scented tea whitening skin-moistening cream and a preparation method thereof. The scented tea whitening skin-moistening cream comprises a plurality of traditional Chinese medicine whitening components, a plurality of biochemical whitening components, whitening and protective components extracted from scented tea and green tea, and base raw materials. The whitening and protective components of traditional Chinese medicines and scented tea are self-prepared from licorice root, bletilla striata, bighead atractylodes rhizome, white poria cocos, Japanese ampelopsis root, white peony root, rose, peony and wintersweet flower. The biochemical whitening components comprise purchased ascorbyl tetraisopalmitate and an amino acid whitening agent. The base raw materials comprise a hexadecanol-octadecanol mixture, jojoba oil, an amino acid moisture-retention agent, fucoidin, a cetyl alcohol-octadecyl alcohol mixture and a cetyl glucoside-octadecyl glucoside mixture. Through uniform blending and scientific composition of the whitening and oxidation-resistant components and the moisture-retention and skin-care base raw materials, the scented tea whitening skin-moistening cream is a novel, safe and reliable scented tea whitening skin-moistening cream product having lasting effects.
In men with previously negative prostate biopsy and persistent elevated prostate-specific antigen (PSA) value, it is unclear which biopsy strategy offers the highest detection rate for significant prostate cancer. The hypothesis of this study is that targeted MRI/ultrasound fusion-guided biopsy improves the detection rates of significant prostate cancers compared with systematic transrectal ultrasound-guided prostate biopsy.

Men with at least one previously negative transrectal ultrasound-guided biopsy and persistently elevated PSA values (\> 3 ng/ml) or PSA velocity \>0.75 ng/ml/p.a. will be submitted to a multiparametric MRI examination of the prostate. Subsequently, all participants will be randomized (1:1) into both study arms. In study arm A patients will be submitted to the gold-standard which comprises systematic transrectal ultrasound--guided prostate biopsy. In study arm B patients will be submitted to targeted prostate biopsy based on the multiparametric MRI findings. Targeted biopsies will be performed using MRI/ultrasound fusion-guided.
Hypersensitivity reactions including infusion-associated events have been reported during and post-infusion with INMAZEB. These may include acute, life-threatening reactions during and after the infusion. Monitor all patients for signs and symptoms including, but not limited to, hypotension, chills and elevation of fever, during and following INMAZEB infusion. In the case of severe or life-threatening hypersensitivity reactions, discontinue the administration of INMAZEB immediately and administer appropriate emergency care [see Adverse Reactions (6.1)].

Infusion could not be completed in 1% of subjects who received INMAZEB due to infusion-associated adverse events. The rate of infusion of INMAZEB may be slowed or interrupted if the patient develops any signs of infusion-associated events or other adverse events [see Adverse Reactions (6.1)].
PURPOSE: A plant extract with reduced toxicity by fermentation with Lactobacillus paracasei is provided to improve anti-inflammation properties and to prevent or treat inflammatory diseases. CONSTITUTION: Houttuynia cordata extract has reduced toxicity by fermentation with Lactobacillus paracasei. Chrysanthemum zawadskii var. latilobum extract has reduced toxicity by fermentation with Lactobacillus paracasei. A method for reducing toxicity of a plant extract comprises: a step of preparing Houttuynia cordata, Chrysanthemum zawadskii var. latilobum, or magnolia; and a step of fermenting the extract with Lactobacillus paracasei.
The present invention belongs to the technical field of traditional Chinese medicine, which provides external application plaster for curing the arthralgia of human bodies. The plaster is mainly characterized in that the plaster uses dragon blood, curcuma longa, etc. as pioneer medicine to perform the functions of promoting the circulation of qi, activating the blood circulation to dissipate blood stasis, removing swelling and alleviating pain, dahurian angelica root, Chinese ephedra, etc. are used for dispelling coldness, activating collaterals and alleviating pain, chuan rhizoma tuber, pubescent angelica root, etc. are used for dispelling wind, activating collaterals and alleviating pain, buck grass, black-tail snake, etc. are used for relaxing tendons, activating collaterals and alleviating pain, acanthopanax bark, dipsacus root, etc. are used for removing wind, reducing spasm, strengthening the tendon and the bone, activating collaterals, benefiting joints and alleviating pain, arisaema tuber, white mustard seed, etc. are used for removing rheumatism and dispelling insubstantial phlegm, gardenia, honeysuckle flower, etc. are used for clearing away heat and toxic substances, removing wind from collaterals and removing swelling, spicebush root, sea horse, etc. are used for nourishing and promoting the blood circulation, promoting the circulation of qi, absorbing moisture, removing toxic substances and softening and dispelling clots, and astragalus root, aurantii immaturus, etc. are used for resisting hypersusceptibility and improving immunity. The combination of all of the medicine has the effects for permeating the interior, collecting the thickness and regulating the interior and the exterior so as to achieve the goals for dispelling clots, activating the circulation of qi, dredging channels and collaterals and removing external pathogen. The present invention is endlessly improved and perfected by a plurality of clinical trials for several years. The present.
The present study aimed to investigate the effects of deoxynivalenol (DON) stimulation on inflammatory injury and the expression of the glucose transporters sodium-dependent glucose transporter 1 (SGLT1) and glucose transporter protein 2 (GLU2) in porcine small intestinal epithelial cells (IPEC-J2). Additionally, the study aimed to provide initial insights into the connection between the expression of glucose transporters and the inflammatory injury of IPEC-J2 cells. DON concentration and DON treatment time were determined using the CCK‑8 assay. Accordingly, 1.0 µg/mL DON and treatment for 24 h were chosen for subsequent experiments. Then IPEC-J2 cells were treated without DON (CON, N = 6) or with 1 μg/mL DON (DON, N = 6). Lactate dehydrogenase (LDH) content, apoptosis rate, and proinflammatory cytokines including interleukin (IL)-1β, Il-6, and tumor necrosis factor α (TNF-α) were measured. Additionally, the expression of AMP-activated protein kinase α1 (AMPK-α1), the content of glucose, intestinal alkaline phosphatase (AKP), and sodium/potassium-transporting adenosine triphosphatase (Na+/K+-ATPase) activity, and the expression of SGLT1 and GLU2 of IPEC-J2 cells were also analyzed. The results showed that DON exposure significantly increased LDH release and apoptosis rate of IPEC-J2 cells. Stimulation with DON resulted in significant cellular inflammatory damage, as evidenced by a significant increase in proinflammatory cytokines (IL-1β, IL-6, and TNF-α). Additionally, DON caused damage to the glucose absorption capacity of IPEC-J2 cells, indicated by decreased levels of glucose content, AKP activity, Na+/K+-ATPase activity, AMPK-α1 protein expression, and SGLT1 expression. Correlation analysis revealed that glucose absorption capacity was negatively correlated with cell inflammatory cytokines. Based on the findings of this study, it can be preliminarily concluded that the cell inflammatory damage caused by DON may be associated with decreased glucose absorption.
Inhalation of ambient particulate matter (PM) and ozone (O3) has been associated with increased cardiovascular morbidity and mortality. However, the interactive effects of PM and O3 on cardiac dysfunction and disease have not been thoroughly examined, especially at a proteomic level. The purpose of this study was to identify and compare proteome changes in spontaneously hypertensive (SH) rats co-exposed to concentrated ambient particulates (CAPs) and O3, with a focus on investigating inflammatory and metabolic pathways, which are the two major ones implicated in the pathophysiology of cardiac dysfunction. For this, we measured and compared changes in expression status of 9 critical pro- and anti-inflammatory cytokines using multiplexed ELISA and 450 metabolic proteins involved in ATP production, oxidative phosphorylation, cytoskeletal organization, and stress response using two-dimensional electrophoresis (2-DE) and mass spectrometry (MS) in cardiac tissue of SH rats exposed to CAPs alone, O3 alone, and CAPs + O3. Proteomic expression profiling revealed that CAPs alone, O3 alone, and CAPs + O3 differentially altered protein expression patterns, and utilized divergent mechanisms to affect inflammatory and metabolic pathways and responses. Ingenuity Pathway Analysis (IPA) of the proteomic data demonstrated that the metabolic protein network centered by gap junction alpha-1 protein (GJA 1) was interconnected with the inflammatory cytokine network centered by nuclear factor kappa beta (NF-kB) potentially suggesting inflammation-induced alterations in metabolic pathways, or vice versa, collectively contributing to the development of cardiac dysfunction in response to CAPs and O3 exposure. These findings may enhance understanding of the pathophysiology of cardiac dysfunction induced by air pollution and provide testable hypotheses regarding mechanisms of action.
Introduction: Mental health services are stretched in the UK and in need of support. One approach that could improve mental health symptoms is osteopathy. Research suggests that osteopathy influences psychophysiological factors, which could lead to improvements in mental health. The first objective of this protocol is to investigate the feasibility and acceptability of four osteopathic interventions. A secondary aim is to evaluate the interventions' effectiveness in improving psychophysiological and mental health outcomes.

Methods and analysis: This study will be an explanatory mixed-methods design. Participants will be 30 adults who have mild to moderate mental health symptoms and not experiencing any issues with pain. The feasibility and acceptability of the interventions will be the first primary outcome. Secondary outcomes will be physiological measures including heart rate variability (HRV), interoceptive accuracy (IAc) and blood pressure (BP). Psychological outcomes will also be measured by standardised questionnaires. These are being collected pre-and post-intervention. Additional outcomes will include recruitment rates and any adverse events that occur during the study. Participants will be randomised to one of four interventions. These are: high-velocity and articulation techniques (HVAT), soft-tissue massage (STM), craniosacral therapy (CST), and a combination of these three approaches. Participants will be interviewed about their experiences of the study and interventions to aid in assessing the feasibility and acceptability.

Discussion: This study will assess the feasibility and acceptability of conducting osteopathic interventions for improving mental health outcomes. These results from this will help to inform the running of a future randomised controlled trial. The study will also be producing original data which could provide preliminary evidence whether osteopathic approaches are of benefit to individual's mental health, even if they are pain-free.
PURPOSE:To obtain an antitumor antibiotic substance complex by culturing a specific strain of actinomycete in an aqueous solution containing an assimilable carbon source and an assimilable nitrogen source under deep aeration condition. CONSTITUTION:A strain of actinomycete having characteristics of the strain G455-101 is cultured in an aqueous solution containing an assimilable carbon source (e.g. starch, glucose, dextran, maltose, lactose, sucrose, fructose, mannose, molasses, glycerol, etc.) and an assimilable nitrogen source (e.g. protein, hydrolyzed protein, polypeptide, amino acid, casein, urea, etc.) under deep aeration condition preferably at 30-32 deg.C for 4-6 days to obtain the objective antibiotic substance.
A mechanochemical process to synthesize single-crystalline cathode powders for the formation of cathodes in a lithium-ion battery includes mixing a transient metal oxide precursor with a lithium salt mixture. Thereafter, a mechanical agitation process may be applied to selectively melt the lithium salt mixture to form a molten salt liquid that wets, corrodes, and separates the grain boundaries of secondary particles in the transient metal oxide precursor. As a result, the secondary particles are deagglomerated resulting in a colloidal dispersion of primary particles. The mixture is then calcined to facilitate growth of single-crystalline particles from the primary particles, thus forming a single-crystalline cathode powder. The single-crystalline particles exhibit large particle size and little to no phase separation, thus improving electrochemical performance. This highly scalable process can be used to synthesize single-crystalline cathode powders from chemical-grade precursors or black mass.
Women with breast cancer often experience severe fatigue (asthenia) after cancer therapy, seen in approximately 40% of breast cancer survivors. Because older age is a risk factor for fatigue, older breast cancer survivors are at an increased risk versus those in younger age groups. Prior evidence suggests that aerobic exercise reduces inflammation and bioenergenesis disturbance, which are key factors that drive the pathogenesis of fatigue. Although interventional studies suggest that aerobic exercise can improve fatigue in younger breast cancer survivors, anti-fatigue effects of aerobic exercise tended to decrease with increasing age. The investigators postulate that novel interventions combined with aerobic exercise can enhance its effectiveness and alleviate severe fatigue further in older breast cancer survivors.

In this pilot randomized clinical trial, the investigators will enroll 24 female cancer survivors aged ≥ 60 years who were diagnosed with invasive breast cancer but have completed adjuvant therapy for at least 3 months but no more than 1 year. Participants will be randomly assigned to either a center-based walking exercise intervention or a home-based walking exercise intervention for an 8 week period. By completing this pilot study, the investigators will be able to collect preliminary data; refine the recruitment, measurement, randomization, and retention strategy; and adjust the statistical strategy and timeline for the potential full-scale randomized clinical trial.
The method for treating the premenstrual disorders comprises the use of the drugs. When only slight disorders are evident, Magne-B6 is prescribed at a dose of 2 dragees thrice a day within Days 16-25 of the cycle with Erbisol intramuscularly in a volume of 2.0 ml in the evening for the first three days, then twice a day (in the morning and in the evening) for 10 days, and finally once a day for the following 7 days. In the case of the mild form, the treatment is supplemented by Dufaston at a dose of 2.0 mg per os twice a day within Days 16-25 of the cycle for six months. In the case of the severe disorder, the treatment regimen is supplemented with Nyze at a dose of 100.0 mg twice a day in P-phase of the cycle. In the case of premenstrual dystrophic disorders, Zoloft is prescribed at a dose of 50.0 mg once a day in the morning within Days 5-25 of the cycle and Dostinex is prescribed at adose of 0.25 mg twice a week. Both drugs are used for six months.
The invention belongs to the technical field of organic synthetic chemistry, and discloses a diversity-oriented synthesis method of rhodium-catalyzed alpha-carboline and beta-carboline-1-ketone derivatives. The alpha-carboline and beta-carboline-1-ketone compounds have structures shown in the following formula (I) and formula (II) respectively. The two classes of target compounds are prepared according to the following steps: alkynol (1 equivalent), indole-2-amide (1.2 equivalent), 5mol% dichloro (pentamethylcyclopentadienyl) rhodium (III) dimer ([ Cp ] RhCl  2 ] 2 ), cesium carbonate (2 equivalent) were added to a dry Schlenk flask, and the reaction was stirred at room temperature for 4 hours under the condition of DMF (N, N-dimethylformamide) as a solvent in an argon atmosphere until the reaction was completed (the reaction process was monitored by TLC or LC-MS). After completion of the reaction, ethyl acetate (15 ml x 3) was added to extract three times, and the organic phases were combined and washed twice with saturated brine (10 ml x 2). And (3) collecting an organic phase, drying the organic phase by using anhydrous sodium sulfate, filtering, spin-drying the filtrate, and separating and purifying the filtrate by using silica gel column chromatography to finally obtain the alpha-carboline and beta-carboline-1-ketone compounds. The invention realizes the diversity-oriented synthesis of the alpha-carboline and beta-carboline-1-ketone compounds, and the method has the characteristics of mild condition, simple operation and the like.
BACKGROUND: Garlic polysaccharides (GPs) constitute over 75% of the dry weight of garlic. They are characterized by fructan with a 2,1-β-d-Fruf backbone and 2,6-β-d-Fruf branches. Studies have suggested a role for GPs in regulating gut microbiota but whether they possess a comprehensive function in maintaining intestinal well-being and can serve as effective prebiotics remains unknown. To explore this, varied doses of GPs (1.25-5.0 g kg-1 body weight) and inulin (as a positive control) were administered to Kunming mice via gavage, and their effects on the intestinal epithelial, chemical, and biological barriers were assessed. A constipation model was also established using loperamide to investigate the potential effects of GPs on the relief of constipation.
RESULTS: Administration of GPs significantly upregulated expression of tight-junction proteins and mucins in Kunming mouse small-intestine tissue. Garlic polysaccharides elevated cecal butyric acid content, reduced the abundance of Desulfobacterota, and decreased the ratio of Firmicutes to Bacteroidetes (the F/B ratio). Garlic polysaccharides also promoted the growth of Bacteroides acidifaciens and Clostridium saccharogumia. Tax4Fun functional predictions suggested the potential of GPs to prevent human diseases, reducing the risk of insulin resistance, infectious diseases, and drug resistance. Garlic polysaccharides also exhibited a beneficial effect in alleviating loperamide-induced constipation symptoms by enhancing small intestinal transit, softening stool consistency, accelerating bowel movements, and promoting the release of excitatory neurotransmitters.
CONCLUSIONS: These findings highlight the important role of GPs in maintaining gut fitness by enhancing intestinal barrier function and peristalsis. Garlic polysaccharides are promising prebiotics, potentially contributing to overall intestinal well-being and health. © 2024 Society of Chemical Industry.