anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to pharmacology and to compositions for the preparation of antitumor agents, said compositions being complexes of divalent platinum salts and alloferon peptides, and to pharmaceutical compositions containing said complexes. The invention can be used for preparing preparations used in oncology. The technical result of the present invention is that the composition can be used as a basis for different types of injectable or lyophilized powder formulations, which have anti-tumor efficacy and reduced toxicity. The technical result is achieved by the fact that: the claimed composition for the preparation of an antitumor agent in the form of solution for injection or lyophilized powder containing alloferon peptide is characterized in that a complex compound of bivalent platinum and alloferon oligopeptide is used as an active ingredient. The method for preparing an antitumor agent based on the above composition is characterized in that alloferon peptide is gradually introduced into a solution of cisplatin in 0.9% sodium chloride, then the solution is mixed for 15 minutes, after which the solution is sterilized by filtration through a filter having a hole of 0.2 mm, then poured into an ampoule and sealed. The formulation may be prepared in the form of a lyophilized powder with mannitol as a filler.
Participants will track their water-intake using a smart water bottle for a period of 6 months. Participants will monitor their overall water consumption using a smart water bottle, and daily and weekly summaries of their progress provided by the experimenters.
Participants will be instructed to eat ad libitum from noon - 8:00pm daily and fast from 8:00pm - noon (16-h fast) for 8 weeks. During the 8-h eating window, there will be no restrictions on types or quantities of foods consumed. Participants will meet with a registered dietitian (RD) for 30 minutes at the start of the intervention to review instructions and goals and weekly thereafter. Adherence to the TRE intervention will be assessed as the number of adherent days per week.
This invention relates to antibacterial drug compounds of formula (I) containing a fused isothiazolinone or pyrazolone ring and related compounds. It also relates to pharmaceutical formulations of antibacterial drug compounds. It also relates to uses of the derivatives in treating bacterial infections and in methods of treating bacterial infections. Many of the antibacterial drug compounds contain a isothiazolinone or pyrazolone ring fused to a pyridone ring. The compounds have broad spectrum antibacterial activity but are particularly effective against Gram negative strains. wherein X is selected from S, SO, SO2, O and NR4;
The primary endpoint of this phase II study is to determine the objective response rate (partial response \[PR\] + complete response \[CR\]) of specific pembrolizumab-lenvatinib combination therapy in patients with locally advanced or metastatic cervical cancer. The phase II portion of the trial will follow Simon's minimax two-stage design1.

In the Stage 1, 11 patients will be accrued. If 1 or fewer patients among these 11 patients achieve an objective response with the pembrolizumab-lenvatinib combination therapy, the combination therapy will be rejected and the trial stopped. However, if there are 2 or more patients who exhibit response in the Stage 1, then an additional 24 patients will be entered into the Stage 2, for a total of 35 patients in this phase II study. If 9 or more patients exhibit response among these 35 patients, then the treatment will be considered for further investigation. Any unplanned interim analysis will utilize the sequential conditional probability ratio test (SCPRT)2, which allows an early assessment of statistical evidence for both efficacy and futility, and provides a discordance probability that early trend could be reversed should the trial continue to enroll all 35 patients.
The present invention provides an MPHOSPH1-derived epitope peptide exhibiting cytotoxic T lymphocyte inducibility. The present invention also provides: a polynucleotide encoding said peptide; an antigen-presenting cell presenting said peptide; a cytotoxic T lymphocyte (CTL) targeting said peptide; and a method for inducing the antigen-presenting cell or the CTL. Furthermore, the present invention provides a composition and a pharmaceutical composition which include the peptide, the polynucleotide, the antigen-presenting cell, and the CTL as active ingredients. Moreover, the present invention provides a method which uses the peptide, the polynucleotide, the antigen-presenting cell, the CTL, or the pharmaceutical composition to treat and/or prevent cancer, and/or prevent the postoperative recurrence of cancer. Also provided is a method for inducing an immune response against cancer.The present invention provides an MPHOSPH1-derived epitope peptide exhibiting cytotoxic T lymphocyte inducibility. The present invention also provides: a polynucleotide encoding said peptide; an antigen-presenting cell presenting said peptide; a cytotoxic T lymphocyte (CTL) targeting said peptide; and a method for inducing the antigen-presenting cell or the CTL. Furthermore, the present invention provides a composition and a pharmaceutical composition which include the peptide, the polynucleotide, the antigen-presenting cell, and the CTL as active ingredients. Moreover, the present invention provides a method which uses the peptide, the polynucleotide, the antigen-presenting cell, the CTL, or the pharmaceutical composition to treat and/or prevent cancer, and/or prevent the postoperative recurrence of cancer. Also provided is a method for inducing an immune response against cancer. This display device is a retina scanning display device that has a projection optical system for projecting an image onto the retina of an eye, a curvature correction means for correcting curvature of the image, an image reversing means for reversing the image, and a storage means for storing correction data for correcting the curvature of the image when projecting an image to the left eye and correction data for correcting the curvature of the image when projecting the image to the right eye. On the basis of a switching signal indicating that the side whereon the projection optical system is disposed has been switched from one eye side to the other eye side, the curvature correction means switches from correction data corresponding to the one eye to correction data corresponding to the other eye to carry out curvature correction, and the image reversing means carries out image reversal.
PROBLEM TO BE SOLVED: To obtain a peel off-type pack material mainly removing horny plugs, excellent in removing effects of a filth on the surface of a skin, a sebum, etc., by containing a skin forming agent and a phospholipid. SOLUTION: This peel off-type pack material containing a polymeric compound (e.g.; a polyvinyl alcohol) as a skin forming agent, is blended with a phospholipid (e.g.; a soy bean phospholipid). The amounts of blending are 5-30wt.% skin forming agent and 0.01-50wt.% phospholipid. The pack material has a moderate effect to a skin, does not give any pain in peeling the pack agent, effectively performs the removal of horny plugs clogged in pores of the skin and is useful for the prevention of comedos and inflammation in sebaceous glands. The pack material is applied to all over a face, or partially to a forehead, a surrounding parts of a nose, a chin, etc. by a suitable amount, suitably dried for 10-20min, and then peeled off.
A striking global health development over the past few decades has been the increasing prevalence of overweight and obesity. At the same time, depression has become increasingly common in almost all high-income countries. We investigated whether body weight, measured by body mass index (BMI), has a causal effect on depression symptoms in Finland. Using data drawn from the Cardiovascular Risk in Young Finns Study (N = 1,523, mean age 41.9, SD 5), we used linear regression to establish the relationship between BMI and depression symptoms measured by 21-item Beck's Depression Inventory. To identify causal relationships, we used the Mendelian randomization (MR) method with weighted sums of genetic markers (single nucleotide polymorphisms, SNPs) as instruments for BMI. We employ instruments (polygenic risk scores, PGSs) with varying number of SNPs that are associated with BMI to evaluate the sensitivity of our results to instrument strength. Based on linear regressions, higher BMI was associated with a higher prevalence of depression symptoms among females (b = 0.238, p = 0.000) and males (b = 0.117, p = 0.019). However, the MR results imply that the positive link applies only to females (b = 0.302, p = 0.007) but not to males (b = -0.070, p = 0.520). Poor instrument strength may explain why many previous studies that have utilized genetic instruments have been unable to identify a statistically significant link between BMI and depression-related traits. Although the number of genetic markers in the instrument had only a minor effect on the point estimates, the standard errors were much smaller when more powerful instruments were employed.
Background: People with intellectual disabilities (IDs) and their caregivers face difficulties during the COVID-19 pandemic. However, limited studies have comprehensively investigated their challenges, especially in Japan. We aimed to clarify the concerns and needs of people with IDs and their caregivers during the COVID-19 pandemic in Japan. Method: From March to August 2021, 27 in-depth interviews were conducted with principal caregivers of people with moderate to profound IDs in Japan. We then transcribed the interviews and conducted deductive coding using predetermined codes focused on their daily life difficulties. Inductive coding was used to ensure that no important themes were overlooked. Results: We found four concerns and four needs among people with IDs and their caregivers as significant themes. Conclusions: Our results provide useful information for supporting people with IDs and their caregivers, especially among those who need medical or social care in accordance with the infection control and social-distancing policies.
A system, a method, and an electronic platform provide co-management for two or more business entities. In one aspect, the disclosure provides for a method including retrieving an electronic record for a client and storing first electronic record information for the client corresponding to a diagnosis of the client by the first business entity. The client is referred to the second business entity in response to the recommended service of the client, corresponding to service provided by the second business entity. The electronic record is provided to the second business entity, and second electronic record is stored for the client corresponding to service of the client by the second healthcare business entity. At least one follow-up visit is scheduled for the client at one of the first business entity or the second business entity. A first portion of a referral fee from the second business entity is distributed to the first business entity, and a second portion of the referral fee is distributed to a co-management system provider.
BACKGROUND: Biliary strictures are a significant cause of morbidity and graft loss in pediatric liver transplant recipients. Risk factors for the development of biliary strictures are not fully established. We aimed to evaluate the incidence of biliary strictures and treatment modalities outcomes and to identify potential risk factors for occurrence.
METHODS: Pediatric patients who underwent liver transplantation in the single tertiary pediatric liver transplant center in Israel were evaluated. We compared demographics, presentation, laboratory results, imaging, treatment, and outcomes between patients with and without biliary stricture. Multivariate regression analyses were used to identify risk factors for biliary strictures.
RESULTS: Among 121 pediatric liver transplant patients, 65 (53.7%) were males; the median age at the time of liver transplantation was 43 (3-215) months. Fifteen patients (12.4%) had biliary strictures following transplantation. One (7%) patient with biliary stricture was treated via endoscopic retrograde cholangiopancreatography, and 12 patients (80%) underwent interventions via a percutaneous transhepatic approach. Nine of the 12 patients were treated successfully, requiring one or multiple procedures, while the remaining had surgery or laser therapy. Risk factors for the development of biliary strictures were biliary leak, acute cellular rejection, and the presence of two biliary anastomoses.
CONCLUSIONS: In our cohort, the presence of two biliary anastomoses and post-transplant complications including acute cellular rejection and early biliary leaks were associated with biliary strictures in pediatric liver transplantation recipients. Percutaneous transhepatic interventions result in good outcomes in most patients.
The invention relates to an ointment for treating arthralgia, which comprises the following components in part by weight: herba Lycopodii, radix Aconiti, semen Brassicae campestris, radix Semiaquilegiae, semen Brassicae campestris, semen Sinapis Albae, Moschus, radix Clematidis, and ovum gallus Domesticus album. The preparation method comprises the following steps: 1) preparing a material; 2) grinding and mixing; 3) and (5) modulating. The invention has the advantages that: the traditional Chinese medicine is prepared from a plurality of herbal medicines, is reasonable in combination, small in dosage, green and environment-friendly, simple to operate, remarkable in curative effect and small in side effect; can be directly applied to affected part for treating and regulating body function. Has good effect on externally conditioning cervical vertebra, shoulders, waist and legs, and is particularly suitable for patients with severe rheumatism and cold dampness. All the medicines have obvious effect in the treatment process. Has good market popularization value.
<P>PROBLEM TO BE SOLVED: To provide compositions and methods for the construction of nucleic acids comprising all or a portion of a viral genome.  <P>SOLUTION: The recombinant viral genome may be constructed to contain multiple recombination and/or topoisomerase recognition sites. The compositions include vectors having multiple recombination sites with unique specificity that contain all or a portion of a viral genome. The methods permit the insertion of a sequence of interest into a viral genome using recombinational and/or topoisomerase-mediated cloning. There are also provided methods of constructing recombinant virus, methods of expressing polypeptides, and methods of expressing fusion polypeptides.  <P>COPYRIGHT: (C)2011,JPO&INPIT
Establishment of sterile areas and cleaning of the skin around the knee with a povidone-iodine solution, followed by an injection of local anesthetic (5 mL of 2% mepivacaine hydrochloride) into the outer mediopatellar zone. The anesthetic was allowed to act, and an access way was then opened with a No. 16 abocat. Any effusion in the joint was drained. Then, approximately 100 mL of cold saline was instilled through the outer access way. Once the knee was distended, a further 5 mL of local anesthetic was injected into the inner mediopatellar zone, and a new abocat guide was used to establish the inner drainage way. The lavage proper involved instillation of 4 L of cold (8ºC) saline at a constant flow-rate using a dropper line connected to the entry way; the inner zone was also connected to another, free-fall dropper. Following administration of the joint lavage, the patients were given an intra-articular injection containing 4 ml of a bioengineered hyaluronic acid.
The role of the gut microbiota in the occurrence and progression of primary biliary cholangitis (PBC) is not fully understood. First, the fecal microbiota of patients with PBC (n = 4) (PBC-FMT) or healthy individuals (n = 3) (HC-FMT) was transplanted into pseudo germ-free mice or 2OA-BSA-induced PBC models. The functions, histology and transcriptome of the liver, and microbiota and metabolome of the feces were analyzed. Second, the liver transcriptomes of PBC patients (n = 7) and normal individuals (n = 7) were analyzed. Third, the liver transcriptomes of patients with other liver diseases were collected from online databases and compared with our human and mouse data. Our results showed that PBC-FMT increased the serum ALP concentration, total bile acid content, liver injury and number of disease-related pathways enriched with upregulated liver genes in pseudo germ-free mice and increased the serum glycylproline dipeptidyl aminopeptidase level and liver damage in a 2OA-BSA-induced PBC model. The gut microbiota and metabolome differed between PBC-FMT and HC-FMT mice and reflected those of their donors. PBC-FMT tended to upregulate hepatic immune and signal transduction pathways but downregulate metabolic pathways, as in some PBC patients. The hematopoietic cell lineage, Toll-like receptor, and PPAR signaling pathway were not affected in patients with alcoholic hepatitis, HBV, HCV, HCV cirrhosis, or NASH, indicating their potential roles in the gut microbiota affecting PBC. In conclusion, the altered gut microbiota of PBC patients plays an important role in the occurrence and progression of PBC. The improvement of the gut microbiota is worthy of in-depth research and promotion as a critical aspect of PBC prevention and treatment.
A plastic composition which when protected from moisture can be stored for indefinite periods but which will harden when exposed to water or water vapour is made by mixing hydraulic binders, hygroscopic substances and anhydrous or substantially anhydrous liquids which are at least partially soluble in or miscible with water.  Suitable binders are Portland cement, calcined gypsum, magnesium oxychloride cement and zinc oxychloride cement. Examples of anhydrous liquids are alcohol, glycol acetate, glycerine mono-, di-, or triacetate, dichlorhydrin, ethyl formate, ethyl acetate and ether. The anhydrous liquid itself may constitute the hygroscopic substance (e.g. ethylene glycol, or glycerine monoacetate) or certain metal chlorides (e.g. calcium chloride, magnesium chloride, and zinc chloride) may be used.  In some cases the hygroscopic substance may be a component of the hydraulic binder (e.g. zinc chloride or magnesium chloride in oxychloride cements).  Examples of plastic compositions are (1) 50 parts of magnesium oxide, 20 parts of zinc sulphate and 30 parts of a saturated ethereal solution of magnesium chloride: (2) 72.5 parts of Portland cement and 27.2 parts of a 40 per cent alcoholic solution of calcium chloride: (3) 75 parts of calcined gypsum and 25 parts of a 20 per cent alcoholic solution of calcium chloride: (4) 45 parts of zinc oxide, 20 parts of zinc sulphate, 15 parts of mono-acetin and 20 parts of dichlorhydrin. Other examples are given.
Age-related macular degeneration (AMD) is a common cause of vision loss. The aggressive form of AMD is associated with ocular neovascularization and subretinal fibrosis, representing a responsive outcome against neovascularization mediated by epithelial-mesenchymal transition of retinal pigment epithelium (RPE) cells. A failure of the current treatment (anti-vascular endothelial growth factor therapy) has also been attributed to the progression of subretinal fibrosis. Hypoxia-inducible factors (HIFs) increase gene expressions to promote fibrosis and neovascularization. HIFs act as a central pathway in the pathogenesis of AMD. HIF inhibitors may suppress ocular neovascularization. Nonetheless, further investigation is required to unravel the aspects of subretinal fibrosis. In this study, we used RPE-specific HIFs or von Hippel-Lindau (VHL, a regulator of HIFs) conditional knockout (cKO) mice, along with pharmacological HIF inhibitors, to demonstrate the suppression of subretinal fibrosis. Fibrosis was suppressed by treatments of HIF inhibitors, and similar suppressive effects were detected in RPE-specific Hif1a/Hif2a- and Hif1a-cKO mice. Promotive effects were observed in RPE-specific Vhl-cKO mice, where fibrosis-mediated pathologic processes were evident. Marine products' extracts and their component taurine suppressed fibrosis as HIF inhibitors. Our study shows critical roles of HIFs in the progression of fibrosis, linking them to the potential development of therapeutics for AMD.
PURPOSE: The aim of this study was to analyze the outcomes of pre-Descemet endothelial keratoplasty (PDEK) for failed therapeutic penetrating keratoplasty.
METHODS: This was a retrospective, interventional study that involved 12 eyes of 12 patients with failed therapeutic penetrating keratoplasty that underwent PDEK. All cases had a minimum follow-up of 12 months. The main outcome measures were best-corrected visual acuity, graft clarity, endothelial cell density loss, and graft survival. Corneal clarity was graded on a scale from 0 to 4, where grade 4 denoted an absolutely clear cornea and grade 0 denoted a totally opaque cornea. Three cases underwent PDEK, 6 cases PDEK with phacoemulsification, and 3 cases underwent PDEK with pupilloplasty.
RESULTS: The mean follow-up period for all cases was 18.5 ± 4.9 months. The mean preoperative and postoperative best-corrected visual acuity (in Snellen decimal equivalent) was 0.02 ± 0.01 and 0.54 ± 0.17, respectively, at the last follow-up. Postoperatively, corneal clarity grade 4 was present in 9 eyes, grade 3 in 2 eyes, and grade 2 in 1 eye. Mild subepithelial haze was noted in 2 eyes. The percentage of endothelial cell density loss was 28.2% ± 10.6%. No correlation was observed between the postoperative graft clarity and preoperative specular count (r = -0.021, P = 0.512). Rebubbling was performed for 1 eye that developed partial graft detachment in the first postoperative week. One patient had an episode of rejection that was managed with systemic and topical steroids.
CONCLUSIONS: In patients with failed therapeutic penetrating keratoplasty, PDEK can be a useful alternative for visual rehabilitation as it demonstrates favorable visual outcomes with a good graft survival rate.