anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Subjects who have undergone previous trauma surgeries and have developed an infection will be assessed for protocol inclusion criteria. Patients will be administered a single, oral, 20mg/kg dose of 5-Aminolevulinic Acid (ALA) by a qualified member of their care team. This dose will be administered ideally 3 hours prior to surgery. Fluorescent imaging will be obtained pre and post irrigation and debridement.
OBJECTIVE: This study aimed to explore the effects of sedative doses of propofol and isoflurane on microcirculation in septic mice compared to controls. Isoflurane, known for its potential as a sedation drug in bedside applications, lacks clarity regarding its impact on the microcirculation system. The hypothesis was that propofol would exert a more pronounced influence on the microvascular flow index, particularly amplified in septic conditions.
MATERIAL AND METHODS: Randomized study was conducted from December 2020 to October 2021 involved 60 BALB/c mice, with 52 mice analyzed. Dorsal skinfold chambers were implanted, followed by intraperitoneal injections of either sterile 0.9 % saline or lipopolysaccharide for the control and sepsis groups, respectively. Both groups received propofol or isoflurane treatment for 120 min. Microcirculatory parameters were obtained via incident dark-field microscopy videos, along with the mean blood pressure and heart rate at three time points: before sedation (T0), 30 min after sedation (T30), and 120 min after sedation (T120). Endothelial glycocalyx thickness and syndecan-1 concentration were also analyzed.
RESULTS: In healthy controls, both anesthetics reduced blood pressure. However, propofol maintained microvascular flow, differing significantly from isoflurane at T120 (propofol, 2.8 ± 0.3 vs. isoflurane, 1.6 ± 0.9; P < 0.001). In the sepsis group, a similar pattern occurred at T120 without statistical significance (propofol, 1.8 ± 1.1 vs. isoflurane, 1.2 ± 0.7; P = 0.023). Syndecan-1 levels did not differ between agents, but glycocalyx thickness index was significantly lower in the isoflurane-sepsis group than propofol (P = 0.001).
CONCLUSIONS: Propofol potentially offers protective action against microvascular flow deterioration compared to isoflurane, observed in control mice. Furthermore, a lower degree of sepsis-induced glycocalyx degradation was evident with propofol compared to isoflurane.
The high flow nasal cannula (Optiflow) will be applied as soon as the patient is in the operating room. The patient will be preoxygenated with high flow nasal cannula at 50 L/min for 5 minutes. After induction, general anesthesia will be maintained with a propofol infusion. One breath will be given via facemask to confirm ventilation and then 0.6 mg/kg of rocuronium will be administered. Upon apnea, the Optiflow™ flow will be increased to 70 L/min and jaw thrust will be performed until the patient is adequately relaxed. The video laryngoscope (C-MAC) will then be introduced into the oropharynx and the flexible intubation scope advanced into the trachea with the assistance of the C-MAC. Once the flexible intubation scope is in the trachea, the endotracheal tube will be advanced.
A composition comprising a Clostridium botulinum neurotoxin serotype A (BoNT/A) complex comprising a plurality of variant species, wherein the variant species comprises BoNT/A with a C-terminal truncated light chain and BoNT/A with a full length light chain, wherein the abundance ratio of the truncated or shortened light chain to the full length light chain is less than 3.9. Also claimed is a composition comprising BoNT/A complex comprising variant species, wherein the variant species comprises a C-terminal truncated light chain, wherein the abundance percentage of the truncated light chain is less than 79.5%. The abundance ratio may be measured using anion exchange chromatograph (AEX). The C. botulinum may be a type A Hall strain. The BoNT/A complex may be onabotulinumtoxin A. Also claimed is a method of producing a composition comprising BoNT/A, comprising incubating a culture of C. botulinum bacteria in a fermenter or bioreactor in the presence of CO2 (carbon dioxide) in the headspace. The incubating step may be performed with CO2 and N2 (nitrogen) in the headspace. Also claimed is a method of treating a patient.
INTRODUCTION: Emergency general surgery (EGS) patients are at increased risk for postoperative morbidity and mortality. Obesity is a risk factor for poor outcomes in this population. Our study aimed to explore the association of body mass index (BMI) with postoperative outcomes in patients requiring common EGS procedures.
METHODS: A retrospective review of the 2018-2020 National Surgical Quality Improvement Program database identified patients undergoing four common EGS procedures: large bowel resection, small bowel resection, cholecystectomy, and appendectomy. Patients were classified by BMI: normal weight (18.5-24.9 kg/m2), obesity classes I (30-34.9 kg/m2), II (35-39.9 kg/m2), III (40-49.9 kg/m2), and IV (≥50 kg/m2). Main outcomes of interest were major adverse event (MAE) and mortality.
RESULTS: From 2018 to 2020, a total of 82,540 patients underwent one of four common EGS procedures. On unadjusted analysis, obesity class IV had higher mortality rates compared to classes I-III (6.2% vs 3.1%, P < 0.001). Patients in obesity classes I-III had lower odds of MAE and death relative to those of normal weight. Compared to other patients with obesity, those in obesity class IV were at increased risk of MAE (odds ratio 1.27; 95% confidence interval 1.13-1.44) and death (odds ratio 1.69; 95% confidence interval 1.34-2.13).
CONCLUSIONS: Patients with varying degrees of obesity have different risk profiles following common EGS procedures. While patients in lower obesity classes had reduced odds of adverse outcomes, those with BMI ≥50 kg/m2 were particularly at greater risk for postoperative morbidity and mortality. This vulnerable population warrants further investigation and increased vigilance to ensure high-quality care.
The activities during health screening before the study and at the end of study is similar to the control. Individuals are provided with an educational brochure upon receiving their screening results. Participants will then go through a baseline lifestyle tracking session using a study-issued smartphone and smartwatch, pre-installed with certain study applications, which will be used for the lifestyle tracking sessions. The experimental arm will go through 4 additional lifestyle tracking sessions (i.e., total of 5 including baseline), of which 1 will include Continuous Glucose Monitoring (CGM) tracking. For this CGM tracking session, participants will receive real-time feedback through the study applications, which will display the CGM trace. The data collected during the lifestyle tracking sessions will be discussed with the participants during 3 face-to-face coaching and 2 tele-coaching sessions, where the participants will develop and implement lifestyle change action plans.
Subjects were given 5 days of placebo. On day 5, they were given a single dose of niacin (600 mg) administered 30 minutes after the last dose of placebo. Urine was collected sequentially for analysis. The same subjects came back for cross-over study and were assigned to Aspirin group. There was a 2-week washout period between each treatment.
The invention belongs to the pharmaceutical field, provides a pharmaceutical composition for treating lead poisoning and aims to solve the technical problem that medicines in the prior art have poor effects of treating lead poisoning in animals or human. The pharmaceutical composition provided by the invention contains a garlic bulb filtrate and a pitaya filtrate, wherein the volume ratio of the garlic bulb filtrate to the pitaya filtrate is 1: 0.1-5; the garlic bulb filtrate is obtained by crushing, extruding and filtering garlic bulb; and the pitaya filtrate is obtained by crushing, extruding and filtering pitaya. The invention also provides a preparation method of the above pharmaceutical composition and an application of the pharmaceutical composition in the preparation of medicines for treating the lead poisoning disease. It is found in the invention that the pitaya and garlic bulb stock solutions both have an effect of reducing the toxicity. But the detoxifcation effect is excellent when pitaya is mixed with garlic bulb in different ratio, and the ratio of garlic to pitaya is preferably 1:3. It is proved through tests that the pitaya and garlic bulb compound can help discharge lead from the body so as to reduce the toxicity and minimize the harm of heavy metal to the body.
The present disclosure relates to novel imidazo[1,2-?]pyridine derivatives, and more particularly to imidazo[1,2-?]pyridine derivatives having an excellent activity of inhibiting gastric acid secretion, methods for preparing the same, and the use thereof. The imidazo[1,2-?]pyridine derivatives according to the present disclosure have gastric acid secretion inhibitory activity, and thus may be effectively used for the prevention or treatment of gastrointestinal inflammatory diseases or gastric acid-related diseases. (Fig. 1)
Disclosed is a method for selecting a suitable inhaler device to a user. The method comprises using a spirometer and a computer comprising a display. The method comprising the following steps: A) connecting the spirometer and the computer; B) the computer, or spirometer, indicating to the user to inhale through the spirometer; C) the spirometer sending flow over time data of the inhalation made to the computer; and D) the computer comparing the flow over time data with dose emission over time data for a range of inhalers and indicating the suitable inhaler from the range of inhalers as the inhaler with the largest dose emission within the flow over time data. Disclosed is also a system for establishing a suitable inhaler device. The system comprises a spirometer and a computer connectable to each other for data transfer. The spirometer or the computer is configured to indicate to the user to inhale through the spirometer. The spirometer is configured to send flow over time data of the inhalation made to the computer. The computer is configured to compare the flow over time data with dose emission over time data for a range of inhalers and indicating the suitable inhaler of the range of inhalers as the inhaler with the largest dose emission within the flow over time data.
Petrolatum Composition and Process For Its Manufacture Petrolatum based compositions (i.e., composition in which the emollient petrolatum comprises greater than or equal to 50% of the composition) are desirable because of the excellent moisturization properties provided by petrolatum. However, it has sensory negatives perceived by consumers. Specifically, because of the oily/greasy and "tacky" (i.e., slightly adhesive or gummy to touch) feel, petrolatum has certain limits to the scope of application. We have found a way to overcome this problem using a copolymer which furthermore avoids the undesirable use of additional oil. A composition is therefore provided comprising: i) 50% to 99.95 % by weight petrolatum; ii) greater than 0.05% by weight of a copolymer bearing greater than 70% long chain alkyl. said composition having an enthalpy of between 30 and 65, preferably 40 and 60, even more preferably 45 and 55 J/g, the petrolatum number average crystal size being less than 10 μm, preferably less than 5 μm, more preferably less than 1 μm.
The present invention provides a kidney-strengthening and pregnancy assisting granule for treating sexual disorder for female and male, male sterility and female sterility, and a preparation process thereof. The granule is composed of twelve Chinese herbal medicines of angelica, ginseng, antler, cistanche salsa, dodder seed, prepared rehmannia root, sharpleaf galangal fruit, barbary wolfberry fruit, tremolite or tremolite asbestos, common cnidium fruit, Chinese magnolivine fruit, semen astragali complanati, etc. as raw materials. The raw materials are pulverized, decocted, extracted, filtered, concentrated, granulated, etc. to prepare the granule. The granule has unique prescription and preparation process, plays good therapeutical effect on sexual disorder for female and male, deficiency of kidney qi, loss of libido, yin deficiency, no inoculation functions, etc. The total effective rate reaches more than 96%.
Fluoride F 18 decays by positron (β+) emission and has a half-life of 109.7 minutes. Ninety-seven percent of the decay results in emission of the positron with a maximum energy of 633 keV and 3% of the decay results in electron capture with subsequent emission of characteristic X-rays of oxygen. The principal photons useful for diagnostic imaging are the 511 keV gamma photons, resulting from the interaction of the emitted positron with an electron (Table 2). Fluorine F 18 atom decays to stable 18O-oxygen. 

* Produced by positron annihilation

[3] Kocher, D.C. Radioactive Decay Data Tables DOE/TIC-11026, 69, 1981.

The specific gamma ray constant for fluoride F 18 is 5.7 R/hr/mCi (1.35 x 10 -6 Gy/hr/kBq) at 1 cm. The half-value layer (HVL) for the 511 keV photons is 4.1 mm lead (Pb). A range of values for the attenuation of radiation results from the interposition of various thickness of Pb. The range of attenuation coefficients for this radionuclide is shown in Table 3. For example, the interposition of an 8.3 mm thickness of Pb with a coefficient of attenuation of 0.25 will decrease the external radiation by 75%. 

Table 4 lists the fraction of radioactivity remaining at selected time intervals from the calibration time. This information may be used to correct for physical decay of the radionuclide. 

* Calibration time
The incidence of lumbar disc herniation has gradually increased in recent years, and most patients have symptoms of low back pain and nerve compression, which brings a heavy burden to patients and society alike. Although the causes of disc herniation are complex, intervertebral disc degeneration (IDD) is considered to be the most common factor. The intervertebral disc (IVD) is composed of the upper and lower cartilage endplates, nucleus pulposus, and annulus fibrosus. Aging, abnormal mechanical stress load, and metabolic disorders can exacerbate the progression of IDD. Among them, high glucose and high-fat diets (HFD) can lead to fat accumulation, abnormal glucose metabolism, and inflammation, which are considered important factors affecting the homeostasis of IDD. Diabetes and advanced glycation end products (AGEs) accumulation- can lead to various adverse effects on the IVD, including cell senescence, apoptosis, pyroptosis, proliferation, and Extracellular matrix (ECM) degradation. While current research provides a fundamental basis for the treatment of high glucose-induced IDD patients. further exploration into the mechanisms of abnormal glucose metabolism affecting IDD and in the development of targeted drugs will provide the foundation for the effective treatment of these patients. We aimed to systematically review studies regarding the effects of hyperglycemia on the progress of IDD.
The invention discloses perfume. The perfume comprises following components by weight: 35-45 parts of ethanol, 20-25 parts of isopropanol, 10-15 parts of citric acid, 5-10 parts of hyaluronic acid and 10-15 parts of essence. The formula of the perfume is reasonable. Raw materials of the perfume are easily available. The manufacturing method is simple and the cost is low. The operation in using processes is convenient. The perfume has advantages of long flavor lasting time after being used, and the like.
OBJECTIVE: To develop and validate a computed tomography (CT)-based scoring system for evaluating the risk of dural defects (DDs) in anterior surgery for cervical ossification of the posterior longitudinal ligament (OPLL).
METHODS: We retrospectively analyzed CT imaging features of 114 OPLL patients in our institute who received anterior decompression surgery. Intraoperative DDs were found in 16 patients. A multivariable logistic regression was used to evaluate the predictors. According to the odd ratio of the included risk factors, we developed a CT scoring system for evaluating the risk of DDs in anterior OPLL surgery. The system was further validated in an independent group of 39 OPLL patients.
RESULTS: We developed a CT scoring system as follows: hook sign (2 points), K-line (-) (1 point) and broad base (1 point). Thus, the system comprised 4 total points, and patients were at high risks of dural defects when the score ≥3 points. The operating characteristics of a score ≥3 for predicting DDs in the validation group were: sensitivity of 0.83, specificity of 0.94, LR positive of 13.75, LR negative of 0.18 and AUC of 0.886. The discriminatory ability of the proposed score could be demonstrated in the validation cohort.
CONCLUSIONS: The relatively simple and easy-to-use scoring system we propose integrates the 3 most reliable spinal CT findings observed in patients with OPLL and a DD. The likelihood to identify the underlying risks of spinal CSF leaks may be useful to triage patients who may benefit from indirect decompression techniques.
The present invention relates to biomarkers useful in adoptive cell therapy. A biomarker contemplated is CD150, also known as SLAM or SLAMF 1. Here we demonstrate that expression of CD150 on tumor infiltrating lymphocyte infusion products correlates with the response rates seen in those patients. High CD150 expression can be seen in patients who continue to have a complete response, and low expression can be seen in patients who are not responsive to treatment. The present invention relates to the use of biomarkers for predicting the response rate of treated patients or stratifying treated patients. It also encompasses the use of the receptor in general in adoptive cell therapy regimens, including but not limited to over-expressing the receptor in a T cell population or isolating CD150 expressing cells to improve efficacy.
This product contains benzyl alcohol as a preservative. The administration of intravenous solutions containing the preservative benzyl alcohol has been associated with the "gasping syndrome", and death in neonates. Symptoms include a striking onset of gasping respiration, hypotension, bradycardia, and cardiovascular collapse. Although the normal therapeutic dose of this product delivers amounts of benzyl alcohol that are substantially lower than those reported in association with the "gasping syndrome", the minimum amount of benzyl alcohol at which toxicity may occur is not known and total daily benzyl alcohol exposure may be increased by concomitant medications.

The risk of benzyl alcohol toxicity depends on the quantity administered and the liver and kidneys' capacity to detoxify the chemical. Premature and low birth weight infants may be more likely to develop toxicity.
BACKGROUND: Adults with physical or intellectual disability are less active than those without disability.
OBJECTIVE: To review literature regarding sport participation in adults with physical or intellectual disability. Specifically, to examine characteristics of available studies including participants, interventions, outcomes, and impact.
METHODS: A scoping review was completed. Searches of 6 databases and a trial registry plus citation tracking were undertaken. Two independent reviewers screened items for eligibility and extracted data about the studies, participants, interventions, and outcomes. A single reviewer extracted data to quantify impacts of sport participation, classified as favorable, insignificant, or unfavorable.
RESULTS: 164 studies involving 11,642 participants were included. Most studies (128/164) used a cross-sectional design. Most participants were men (81%) with physical disability (135/164), and spinal cord injury was the most prevalent underlying health condition (54%). Most studies evaluated a mix of sports (83/164) in a disability-specific context (159/164), with basketball or wheelchair basketball being the most common individual sport (28/164). Physical impairment was the most frequently reported outcome domain (85/334 results). Sports participation impact was classified as 55% favorable, 42% insignificant, and 3% unfavorable.
CONCLUSIONS: There were many favorable and few unfavorable outcomes for participation in sport for adults with physical or intellectual disability. More research is needed to address the evidence gaps of gender, health condition, and type of sport, and to use more rigorous research designs to evaluate the effects of sport participation. While new evidence is generated, we suggest adults with physical or intellectual disability be encouraged to engage in sport.
REGISTRATION: PROSPERO registration number CRD42018104379.
Psoriasis is a multifaceted chronic inflammatory skin disease; however, its underlying molecular mechanisms remain unclear. In this study, we explored the role of fucosylation in psoriasis using an imiquimod-induced psoriasis-like mouse model. ABH antigen and fucosyltransferase 1 (Fut1) expression was reduced in the granular layer of lesional skin of patients with psoriasis. In particular, the blood group H antigen type 2 (H2 antigen)-a precursor of blood group A and B antigens-and FUT1 were highly expressed throughout the spinous layer in both patients with psoriasis and the skin of imiquimod-treated mice. Upon the application of imiquimod, Fut1-deficient mice, which lacked the H2 antigen, exhibited higher clinical scores based on erythema, induration, and scaling than those of wild-type mice. Imiquimod-treated Fut1-deficient mice displayed increased skin thickness, trans-epidermal water loss, and Gr-1+ cell infiltration compared with wild-type mice. Notably, the levels of CXCL1 protein and mRNA were significantly higher in Fut1-deficient mice than those in wild-type mice; however, there were no significant differences in other psoriasis-related markers, such as IL-1β, IL-6, IL-17A, and IL-23. Fut1-deficient primary keratinocytes treated with IL-17A also showed a significant increase in both mRNA and protein levels of CXCL1 compared with IL-17A-treated wild-type primary keratinocytes. Further mechanistic studies revealed that this increased Cxcl1 mRNA in Fut1-deficient keratinocytes was caused by enhanced Cxcl1 mRNA stabilization. In summary, our findings indicated that fucosylation, which is essential for ABH antigen synthesis in humans, plays a protective role in psoriasis-like skin inflammation and is a potential therapeutic target for psoriasis.