anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a Chinese medicinal external preparation for treating bedsore. The Chinese medicinal external preparation is prepared from the following bulk pharmaceuticals in parts by weight: 8-12 parts of borneol, 10-20 parts of pseudo-ginseng, 10-20 parts of lightyellow sophora root, 8-12 parts of cortex eucommiae, 10-20 parts of sinkiang arnebia root, 15-25 parts of large-leaved gentian, 10-20 parts of common bletilla tuber and 10-20 parts of paris polyphylla. A preparation method comprises the following steps of: preparing each bulk pharmaceutical; mixing; and grinding into powder to obtain the Chinese medicinal external preparation. The Chinese medicinal external preparation disclosed by the invention can be used for treating bedsore, has good putrefaction-removing, bleeding-arresting and tissue regeneration-promoting effects, and contributes to eliminating scars after curing. During treatment, the Chinese medicinal external preparation is used by flushing a wounded area position with hydrogen peroxide, and scattering the Chinese medicinal external preparation on a wounded area. The Chinese medicinal external preparation is used 1-2 times every day. A wounded area can be cured generally in 3-15 days.
OBJECTIVES: To synthesise and map the evidence of a theory- and evidence-based nursing intervention for the prevention of ICU-acquired weakness and evaluate its effectiveness in terms of the incidence of ICU-acquired weakness, incidence of delirium, and length of hospital stay.
METHODS: We searched PubMed, CINAHL, MEDLINE, Academic Search Complete, Embase, Scopus, Web of Science and the Cochrane Library from database inception to November 2023. The eligible studies focused on critically ill patients in the intensive care unit, used a theory- and evidence-based nursing intervention, and reported the incidence of ICU-acquired weakness and/or used the Medical Research Council Scale. The methodological quality of the included studies was critically appraised by two authors using the appropriate Joanna Briggs Institute appraisal tool for randomised controlled trials, quasi-experimental studies, and cohort studies. Additionally, the weighted kappa coefficient was used to assess inter-rater agreement of the quality assessment. Data were reported using a narrative synthesis. This systematic review was registered by the International Prospective Register of Systematic Review (PROSPERO; CRD42023477011).
RESULTS: A total of 5162 studies were initially retrieved, and 9 studies were eventually included after screening. This systematic review revealed that preventive nursing interventions for ICU-acquired weakness mainly include (a) physiotherapy, including neuromuscular electrical stimulation and early rehabilitation, and (b) nutritional support. In addition, (c) airway management, (d) sedation and analgesia management, (e) complication prevention (delirium, stress injury and deep vein thrombosis prevention), and (f) psychological care were also provided. The theories are dominated by goal-oriented theories, and the evidence is mainly the ABCDE bundle in the included studies. The results show that theory- or evidence-based nursing interventions are effective in reducing the incidence of ICU-acquired weakness (or improving the Medical Research Council Scale scores), decreasing the incidence of delirium, shortening the length of hospital stay, and improving patients' self-care and quality of life.
CONCLUSION: Theory- and evidence-based nursing interventions have good results in preventing ICU-acquired weakness in critically ill patients. Current nursing interventions favour a combination of multiple interventions rather than just a single intervention. Therefore, preventive measures for ICU-acquired weakness should be viewed as complex interventions and should be based on theory or evidence. This systematic review is based on a small number of trials. Thus, more high-quality randomised controlled trials are needed to draw definitive conclusions about the impact of theory- and evidence-based nursing interventions on the prevention of ICU-acquired weakness.
In thyroid cancer patients, lymph node dissection includes a comprehensive removal of all the target nodal basins: anterior cervical compartment (level VI) and the superior mediastinal nodes that can be reached via cervical incision (level VII) in CND, and levels IIa-Vb in LND. Clearance of those levels without including the enveloping fasciae in the specimen is referred to hereafter as Standard Neck Dissection (SND), as it is the most common technique applied for thyroid tumors. In Fascial Neck Dissection, the comprehensive clearance of the target basins is achieved by following the planes of coalescence of the cervical fascial layers. Those are avascular and enable the removal of the target nodes en bloc with their investing fascial layers.

The aim of this retrospective study was to compare the outcomes between fascial and standard approach in N1b PTC patients that underwent surgery for N1b papillary thyroid cancer. The primary objective was to achieve a significantly higher nodal yield by applying the fascial neck dissection technique and reduce rates of early loco-regional recurrence. Secondary objectives were the evaluation of short and long-term post-operative complications and the cosmetic result.
The invention belongs to the field of pharmaceutical preparations and discloses vesicles with inner and outer aqueous-phase gradient difference. The vesicles are prepared by treating blank vesicles by adopting an ion exchange method or combining the ion exchange method and a dialysis method or an ultrafiltration method. The invention also provides a preparation method and application of the vesicles; and the preparation method comprises the following steps of: preparing the blank vesicles; treating the prepared blank vesicles by using an ion exchanger; and performing elution treatment so as to prepare the vesicles with inner and outer aqueous-phase gradient difference. The prepared vesicles can be mixed with medicinal solution to realize active medicament carrying so as to prepare the pharmaceutical preparations. The prepared preparations also can be subjected to ion exchange treatment or freeze-drying treatment. The provided vesicles have higher inner and outer aqueous-phase gradient difference, can realize ion gradient medicament carrying of the vesicles and achieve higher encapsulation rate; meanwhile, the preparation method is simple and is low in cost, and the vesicles can be better applied to preparing liposome gel, magnetic liposome and nanoparticles/nanogel.
A system for infusing liquid to a body includes an infusion device, a network interface with a cell phone and wireless link and a network server system capable of communication with the infusion device through the network interface. The server system has access to a file of information specific to the controller for the infusion device. The infusion device includes a source of infusion fluid, a delivery port, a pump between the source of infusion fluid and the delivery port and a controller capable of programmable pump rate and sequence, A method for infusing liquid to a body includes controlling infusion using a programmable controller, establishing a file of information specific to the controller accessible to an extended area network server system and remoteiy transmitting commands to the controller. The information specific to the controller in the file is amended from a control terminal remote from the body. Operating instructions responsive to the updated information in the file are provided over an extended area network to a programmable two-way communication device. The device is capable of communication with the controller to forward operating commands. Requests for a bolus or a basal rate change are made through input to the two-way communication device which responds with commands transmitted over the wireless link to the controller consistent with the operating instructions from the server system. Network access through a monitoring terminal to the incidents of amending information specific to the controller is used for generating payments for the incidents of amending information specific to the controller accessed by the monitoring terminal.
A piece of medical information, e.g., a medical image of tissue, may be received for processing and analysis on a computing device or system. A region of the medical image may be analyzed to determine a presence of one or more contours in the region. One or more properties of the one or more contours may be extracted, where the one or more properties are inputted into a first algorithm to determine an indication of a clinical indication for the region. The indication of cancer may be inputted into a second algorithm to generate a clinical score for the region. Moreover, based at least in part on the clinical score, an instruction to acquire a second medical image of the tissue is provided. Then, in response to receiving the second medical image, the clinical score is revised based at least in part on the second medical image.
The invention relates to a spiro-amino acid ester compound, and a preparation method and application thereof. According to the technical scheme of the invention, the spiro-amino acid ester compound has a structural formula as shown in a formula (I) in the description. The preparation method is as follows: benzylamine, carbonate and pentaerythrityl tetrabromide which serve as raw materials are subjected to condensation and reflux in a polar solvent at 130 to 150 DEG C to obtain a target product. The target product can be obtained from the benzylamine, potassium carbonate and the pentaerythrityl tetrabromide which serve as raw materials through one-pot reaction. The compound has a spiro structure, contains an amino acid ester group and is a novel spiro-amino acid ester compound. The method provided by the invention is simple in operation, relatively short in production cycle, easy in purification and expected to be widely applied to industry, agriculture and medicine.
Use of plasma of neutral argon in the eradication of tumor implants at the mesentery level, with different doses (established according to the percentage of energy used) and distances of application and time. It will also be compared in-vivo with control therapy of Monopolar electrofulguration at a power of 100 in cut mode with ball-tip terminal.
<P>PROBLEM TO BE SOLVED: To provide a new 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt useful as an anti-HIV agent.  <P>SOLUTION: The invention relates to a compound represented by the general formula [I], a pharmaceutically acceptable salt thereof, or a solvate of the compound or the salt; and a pharmaceutical composition, an anti-HIV agent, and an HIV integrase inhibitor, each comprising the compound. The compound has an action of inhibiting the HIV integrase activity, and therefore is useful as an anti-HIV agent or a therapeutic or prophylactic agent for AIDS. By using in combination with other anti-HIV agent such as a protease inhibitor and a reverse transcriptase inhibitor, the compound can act as a more effective anti-HIV agent. Further, because of its high inhibitory activity specifically against an integrase, the compound can act as an agent which is safe for a human body and has few adverse side-effects.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Subjects received 3 doses of placebo. Placebo was administered intramuscularly in the deltoid muscle of the non-dominant arm according to a 0, 1, 6-month schedule.
BACKGROUND: Diabetes is considered a general surgical risk factor, but with few data from enhanced recovery (ERAS) otherwise known to improve outcome. Therefore, this study aimed to investigate postoperative outcomes of patients with diabetes who underwent video-assisted thoracoscopic surgery (VATS) lobectomy in an established ERAS setting.
METHODS: We retrospectively analysed outcome data (hospital stay (LOS), readmissions, and mortality) from a prospective database with consecutive unselected ERAS VATS lobectomies from 2012 to 2022. Complete follow-up was secured by the registration system in East Denmark.
RESULTS: We included 3164 patients of which 323 had diabetes, including 186 treated with insulin and antidiabetic medicine, 35 with insulin only and 102 with antidiabetic medicine only. The median LOS was 3 days, stable over the study period. There were no differences in terms of LOS, postoperative complications, readmissions or 30 days alive and out of hospital. Patients with diabetes had significantly higher 30- and 90-day mortality rates compared to those without diabetes (p < .001), but also had higher preoperative comorbidity. Preoperative HbA1c levels did not correlate with postoperative outcomes.
CONCLUSION: In an ERAS setting, diabetes may not increase the risk for prolonged LOS, complications, and readmissions after VATS lobectomy, however with higher 30- and 90-day mortality probably related to more preoperative comorbidities.
Clinicians will receive academic detailing at month 0 and practice facilitation at month 3. At month 9, clinics will be randomized to receive physician peer consulting. Clinicians of the clinics will meet up to 4 times, quarterly, with the physician peer consultant.
Received and asked to consume 2 tbsp of peanut butter 2 hours before bedtime 5 nights per week for 7 weeks and to stop eating after that before bed. Other than that, asked to maintain normal diet and activity.
Two physiopathological phases exist during COVID-19 disease: The early phase is mainly induced by the virus itself. It is imperative not to decrease the immune host response during this phase by prohibiting the use of non steroidal anti-inflammatory drugs or corticosteroids at this stage and developing an anti-viral strategy. The late phase, around Day 7-9, depends only upon host response and is linked to an excessive inflammatory response with a major increase of inflammatory cytokines such as IL-6, MCP-1, GCSF indicative of IL-1b excess, as well as IP-10, MIP-1, indicative of IFNg signature, corresponding to a "cytokine storm". Clinical and biological features during Still's disease (complicated in 10% of cases with hemophagocytosic lymphohistiocytosis inducing cytopenia, hepatic insufficiency, major hyperferritinemia and multi-organ failure) are close to those reported during COVID-19 and underline physiopathological similarities.

Anakinra (KINERET) is an IL-1 pathway (IL-1ra) specific inhibitor that has been used for 15 years, also largely blocking IL-18 production. Adult Still's disease is very effectively treated with anakinra. During sepsis with hyperferritinemia, IL-1ra demonstrated patient survival improvement. Ruxolitinib (JAKAVI) inhibits the downstream IFNg pathway targeting JAK kinase receptor. It has recently proved its efficiency in hemophagocytosic lymphohistiocytosis refractory forms associated with a multi-organ failure.
Early-stage vulvar cancer is managed by a local excision of the primary tumor and, if indicated, a sentinel node (SN) biopsy to assess the need for further groin treatment. With the SN procedure, many patients can be treated less radically and will experience less complications and morbidity compared with an inguinofemoral lymphadenectomy (IFL). Still, the SN procedure can be further optimized. Different tracers for detecting the SN are being investigated, aiming to optimize detection rates and decrease the burden of the procedure and short-term complications. Until now, no standardized protocols exist for the pathologic workup of the SN, possibly leading to discrepancies in detection of metastases between institutes using different methods. New techniques, such as one-step nucleic amplification, seem to have potential in accurately detecting metastases in other cancers, but have not yet been investigated in vulvar squamous cell carcinoma (VSCC). Furthermore, several studies have investigated the possibility to broaden the indications for the SN procedure, such as its use in recurrent disease, larger tumors, or multifocal tumors. Although these studies show encouraging results, cohorts are small and further studies are needed. Prospective studies are currently investigating these subgroups. Lastly, several studies investigated optimization of groin treatment of patients with a metastatic SN. Inguinofemoral radiotherapy is a good alternative to IFL in patients with micrometastases in the SN, with comparable efficacy and less treatment-related morbidity. Reduction of the radicality of groin treatment is also possible in other ways, such as omitting contralateral IFL in patients with lateralized tumors and a unilateral metastatic SN. In conclusion, the SN procedure is an established procedure in early-stage VSCC, although optimization of the technique, pathologic workup, indications, and treatment in the setting of metastatic disease are the subject of ongoing research.
BACKGROUND: Inflammation is associated with adverse outcomes of chronic kidney disease (CKD) or chronic heart failure (CHF), but few large data exist. We aimed to explore the clinical associations, and prognostic consequences of inflammation-based scores in patients with CKD and CHF.
METHODS: This work was a retrospective cohort study. Glasgow Prognostic Score (GPS), modified Glasgow Prognostic Score (mGPS), Prognostic Nutritional Index (PNI) and Prognostic Index (PI), were used to explore its relationship with CKD progression in patients with CKD stage 1-3b and CHF from the China Renal Data System (CRDS). The composite end point of this study was CKD progression which was defined as eGFR reduction of 40% or progression to end stage renal disease (ESRD).
RESULTS: Of 8491 patients were enrolled. Kaplan-Meier curve showed that compared to the lower inflammation-based scores, the increased scores have a higher rate of CKD progression, whether in GPS, mGPS, PNI or PI (log-rank test, p < 0.001). After considering competing risk events, multivariable Cox hazards analysis revealed that GPS and PNI scores were significantly related to CKD progression [GPS: hazard ratio (HR) 1.40, 95% confidence interval (CI) 1.11-1.76, p = 0.005; PNI: HR 1.54, 95% CI 1.25-1.89, p < 0.001]. PNI showed acceptable prognostic value (C-index = 0.757, 95% CI 0.734-0.78) compared to GPS, mGPS and PI. In subgroup analysis, PNI was consistently related to CKD progression in patients with or without hypertension, DM, MI, VDH and CVD (P for interaction > 0.05).
CONCLUSIONS: Inflammation-based scores, especially PNI may be a useful clinical biomarker for CKD progression in CKD with CHF patients.
As an organ unparalleled in anatomical architecture, the tongue has the versatility to effect regional deformations and positional changes with multiple potential degrees of freedom. Despite an abundance of studies on the tongue and its functions, as well as numerous proposed tongue models over the years, much of the anatomical and biomechanical details of the in vivo human tongue remain poorly understood. Physiologically based biomechanical modeling of the tongue in swallowing is the ultimate objective of this protocol. However, before such modeling can be accurately pursued, a substantial database must be established, and several important, unaddressed issues regarding lingual anatomy and biomechanics must be resolved. These issues include: (1) the compressibility of the human tongue and its common, yet untested, reference as a muscular hydrostat; (2) task induced interactions between lingual musculature and vasculature and region-specific vascular demands; (3) changes in lingual fiber orientation, length, and strain distribution as a function of contraction tasks; and (4) effects of normal aging, disease processes, and task training on lingual myoarchitecture as well as the integration between structure and function. Using advanced 3D MRI, Doppler ultrasonography, and other MR imaging techniques (e.g., tagged MRI, diffusion tensor MRI), this protocol proposes to quantitatively address these issues and contribute to a better understanding of the functional biomechanical as well as myoarchitectural intricacies of the in vivo human tongue.
The objective of this study is to compare and contrast the quality statements and quality indicators across clinical care standards for low back pain. Searches were performed in Medline, guideline databases, and Google searches to identify clinical care standards for the management of low back pain targeting a multidisciplinary audience. Two independent reviewers reviewed the search results and extracted relevant information from the clinical care standards. We compared the quality statements and indicators of the clinical care standards to identify the consistent messages and the discrepancies between them. Three national clinical care standards from Australia, Canada, and the United Kingdom were included. They provided from 6 to 8 quality statements and from 12 to 18 quality indicators. The three standards provide consistent recommendations in the quality statements related to imaging, and patient education/advice and self-management. In addition, the Canadian and Australian standards also provide consistent recommendations regarding comprehensive assessment, psychological support, and review and patient referral. However, the three clinical care standards differ in the statements related to psychological assessment, opioid analgesics, non-opioid analgesics, and non-pharmacological therapies. The three national clinical care standards provide consistent recommendations on imaging and patient education/advice, self-management of the condition, and two standards (Canadian and Australian) agree on recommendations regarding comprehensive assessment, psychological support, and review and patient referral. The standards differ in the quality statements related to psychological assessment, opioid prescription, non-opioid analgesics, and non-pharmacological therapies.
Sex hormone-binding globulin (SHBG) is a homodimeric glycoprotein produced by the human liver and secreted into the systemic circulation where it binds with high affinity sex steroids regulating their availability in blood and accessibility to target tissues. Plasma SHBG levels are altered in metabolic disorders such as obesity, anorexia, and insulin resistance. Several reports have shown that diets in terms of total calories or fat, fiber, or protein content can alter plasma SHBG levels. However, there are many components in a diet that can affect SHBG gene expression in the liver. In order to unravel the molecular mechanisms by which diets regulate SHBG production, it would be necessary to analyze single diet components and/or nutritional factors. This review summarizes the recent advances in identifying different nutritional factors regulating SHBG production and the related molecular mechanism, as well as the clinical implications.
The invention discloses a preparation method for high-activity ginseng extract. The preparation method comprises the following steps of (1) preparing fresh ginseng, and performing pretreatment on the fresh ginseng; (2) performing normal pressure far infrared cooking biotransformation treatment on the ginseng pretreated in the step (1); and (3) performing aftertreatment on the ginseng obtained by the step (2) to obtain the high-activity ginseng extract. The invention also discloses red ginseng extract and black ginseng extract, which are prepared by the method, wherein micromolecular active ginsenoside is not less than macromolecular ginsenoside. The invention also discloses the application of the high-activity ginseng extract. According to the preparation method, the repeated cooking time can be greatly reduced, the activity of the micromolecular ginsenoside can be greatly improved, and side effects of the macromolecular ginsenoside can be reduced. The high-activity ginseng extract is a ginsenoside concentrated solution or concentrated cream, and is used as an ingredient for the preparation of functional food or healthcare food for resisting cancer, treating cancer or reducing side effects on a patient with cancer after chemotherapy.