anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Sepsis is a highly lethal disease that poses a serious threat to human health. Increasing evidence indicates that neutrophil extracellular traps (NETs) are key factors in the pathological progression of sepsis. This study aims to screen potential biomarkers for sepsis and delve into their regulatory function in the pathogenesis. We downloaded 6 microarray datasets from the Gene Expression Omnibus (GEO) database, with 4 as the training sets and 2 as the validation sets. NETs-related genes (NRGs) were obtained from relevant literature. Differential expression analysis was performed on four training sets separately. We intersected differentially expressed genes (DEGs) from the four training sets and NRGs, finally resulting in 19 NETs-related sepsis genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) unearthed that NETs-related sepsis genes were majorly abundant in functions and pathways such as defense response to bacterium and Neutrophil extracellular trap formation. Using the PPI network, the MCC algorithm, and the MCODE algorithm in the CytoHubba plugin, 7 sepsis hub genes (ELANE, TLR4, MPO, PADI4, CTSG, MMP9, S100A12) were identified. ROC curve for each Hub gene in the training and validation sets were plotted, which revealed that the Area Under Curve (AUC) values are all greater than 0.6, indicating good classification ability. A total of 349 miRNAs targeting Hub genes were predicted in the mirDIP database, and 620 lncRNAs targeting miRNAs were predicted in the ENCORI database. The ceRNA regulatory network was constructed using Cytoscape software. Finally, we employed the cMAP database to predict small molecular complexes as potentially effective drugs for the treatment of sepsis, such as chloroquine, harpagoside, and PD-123319. In conclusion, this project successfully identified 7 core genes, which may serve as promising candidates for novel sepsis biomarkers. Meanwhile, we constructed a related ceRNA network and predicted potential targeted drugs, providing potential therapeutic targets and treatment strategies for sepsis patients.
The invention discloses an electronic medical record device. The electronic medical record device comprises a shell 1, a display screen 2, a reading-writing interface 3, a video recording and photographing switch 4, a power switch 5, a fixing assembly 6, a solar cell panel 7, an illuminating lamp 8, an input interface 9, a call button 10 and a pen groove 11, wherein the display screen 2 is used for displaying medical record information, the reading-writing interface 3 is used for being connected with an external reading-writing device, the video recording and photographing switch 4 is used for enabling the video recording or photographing function, the fixing assembly 6 is used for fixing the shell 1, the call button 10 is used for making an emergent call, and the pen groove 11 is used for containing a handwriting pen. The display screen 2 is arranged on the left side of the front face of the shell 1. The power switch 5, the video recording and photographing switch 4 and the reading-writing interface 3 are sequentially arranged on the left side face of the shell 1 from top to bottom. The fixing assembly 6 is arranged above the top of the shell 1. The solar cell panel 7, the illuminating lamp 8, the input interface 9 and the call button 10 are sequentially arranged on the right side of the front face of the shell 1 from top to bottom.
PROBLEM TO BE SOLVED: To release a drug as much as a release amount within a prescribed range on a prescribed position for long hours.SOLUTION: This composite film 30 includes a drug sustained-release portion 11 and an adhesive portion 32 which overlap in layers. The drug sustained-release portion 11 has drug layers 13 formed in a film shape and a biodegradable polymer layer 14. The drug sustained-release portion 11 has, in order from the side of the adhesive portion 32, a drug layer 13, a biodegradable polymer layer 14, and a drug layer 13. The drug layers 13 are drug forms comprising a drug at a given concentration or more. When the drug is released from the drug layer 13 that is exposed on the surface and this drug layer 13 disappears, the biodegradable polymer of the biodegradable polymer layer 14 starts to degrade or dissolve. When the biodegradable polymer layer 14 disappears, the drug is released from the drug layer 13 which contacts the adhesive portion 32. A plurality of pores 33 are formed in the adhesive portion 32, and these pores 33 retain water by a capillary force.
1. Technical Result Increase in efficiency of treatment of inflammatory, respiratory and allergic discases. 2. Essence A compounds of the formula wherein said radicals are defined in the description; pharmaceutical composition containing them are useful for treating inflammatory, respiratory and allergic diseases and conditions, especially asthma; chronic obstructive pulmonary disease including chronic bronchitis, emphysema, and bronchiectasis; chronic rhinitis; and chronic sinusitis. 3. Field of Application Medicine.
Patient will stop aspirin after discharge (DAPT less than 1 months after PCI) (ticagrelor monotherapy). Dosage of ticagrelor would be 90 mg twice a day, and 100 mg of aspirin will be prescribed once a day (during hospitalization).
A method for displaying real-time ablation growth projections is provided. The method includes applying, by a processor, an ablation model to image data of a patient. The ablation model is based on a position of an ablation probe, and the ablation probe is coupled to the processor. The method also includes displaying, on a display coupled to the processor, a projected ablation zone on the image data. The projected ablation zone is based on ablation parameters and the position of the ablation probe. The projected ablation zone includes a margin showing a confidence level. The method further includes ablating by the ablation probe. The ablating is based on an evaluation of the projected ablation zone with respect to a target. A system for performing a microwave ablation procedure is provided. A non-transitory computer-readable storage medium storing instructions is provided.
<P>PROBLEM TO BE SOLVED: To provide a means for improving the stability of urea with time, suppressing a greasy feeling of use and stabilizing a coating on an inner wall of a spraying can in an aerosol preparation containing the urea formulated at a high concentration and further a chemical insoluble or sparingly soluble in water and soluble in a lower alcohol formulated therein.  <P>SOLUTION: The urea is combined with a specific substance, concretely a higher fatty acid, an acidic amino acid, salicylic acid or a salicylic acid derivative and resultant mixture is contained in a stock solution of the aerosol preparation. Furthermore, the chemical insoluble or sparingly soluble in water and soluble in the lower alcohol is formulated together with water and the lower alcohol to provide a soluble or solubilized stock solution. Dimethyl ether, or the like, are preferably used as a propellant. Thereby, it is found that a refreshing feeling of use stable with time without greasiness is obtained and even corrosion of the coating on the inner wall of the spraying can is suppressed.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The use of Revonto in the management of malignant hyperthermia crisis is not a substitute for previously known supportive measures. These measures must be individualized, but it will usually be necessary to discontinue the suspect triggering agents, attend to increased oxygen requirements, manage the metabolic acidosis, institute cooling when necessary, monitor urinary output, and monitor for electrolyte imbalance.

Since the effect of disease state and other drugs on dantrolene sodium-related skeletal muscle weakness, including possible respiratory depression, cannot be predicted, patients who receive intravenous dantrolene sodium preoperatively should have vital signs monitored.

If patients judged malignant hyperthermia susceptible are administered intravenous or oral dantrolene sodium preoperatively, anesthetic preparation must still follow a standard malignant hyperthermia susceptible regimen, including the avoidance of known triggering agents. Monitoring for early clinical and metabolic signs of malignant hyperthermia is indicated because attenuation of malignant hyperthermia, rather than prevention, is possible. These signs usually call for the administration of additional intravenous dantrolene.
Brief Cognitive behavioral therapy intervention will be interviewed by the researcher as part of psychosocial care, with two sessions pre-operative and two post-operative sessions. In the postoperative period, an eye mask and ear plug will be applied to the patient by the researcher on the 3rd and 4th days of the short CBT post-op and between 23:00 and 07:00 at night. Visual Analogue Scale, State Anxiety Inventory, Richmond Agitation-Sedation Scale, Confusion Evaluation Scale in Intensive Care, Richard Campbell Sleep Quality Scale, Daily Follow-up Form will be applied after open heart surgery.
Ovary-specific proteins O1-180, O1-184 and O1-236, polynucleotides encoding them, antibodies which are immunoreactive with them and vectors and host cells containing O1-180, O1-184 or O1-236 are provided. Also provided are methods for detecting cell proliferative or degenerative disorders of ovarian origin and which are associated with O1-180, O1-184 or O1-236. Further provided are methods for the evaluation of potential contraceptives using the proteins of the invention, as well as methods for the screening for genetic mutations in signaling pathways that are associated with some forms of human infertility or gynecological cancers, also using the proteins/mRNAs/genes of the invention. The proteins/mRNAs/genes of the invention may also be used as markers for identifying primary and metastatic neoplasms of ovarian origin and as indicators of developmental anomalies in prenatal screening procedures. Furthermore, assays of the proteins/mRNAs/genes of the invention can be used in diagnostic assays for detecting forms of infertility and other diseases, including germ cell tumors and polycystic ovary syndrome. The proteins of the invention may be useful targets for in vitro fertilization procedures or in enhancing the number of eggs that can be retrieved from the human donor, e.g., in enhancing the success rate.
PROBLEM TO BE SOLVED: To obtain the subject composition of one-pack type preparation, capable of providing a liquid tooth polish by formation of a substance having polishing actions in the oral cavity, by making functions to supply calcium phosphate fine particles in the oral cavity when a mouth is washed in the oral cavity. SOLUTION: This composition has functions of supplying calcium phosphate fine particles in the oral cavity when a mouth is washed in the oral cavity. Calcium primary phosphate is preferable as the source for supplying the calcium phosphate fine particles. The composition is obtained, for example, by mixing water having an acidic pH (about pH <=4.0) by adding an acid (citric acid) with components except an ion source (calcium ion source or phosphate ion source) and an acid, dissolving the components in water, adding the calcium ion source (e.g. calcium primary phosphate), then a phosphate ion source (e.g. sodium secondary phosphate) and adjusting the polymer to pH 6.0 6.5.
Anthropogenic climate change has significantly altered terrestrial and marine ecosystems globally, often in the form of climate-related events such as thermal anomalies and disease outbreaks. Although the isolated effects of these stressors have been well documented, a growing body of literature suggests that stressors often interact, resulting in complex effects on ecosystems. This includes coral reefs where sequential associations between heat stress and disease have had profound impacts. Here we used the model cnidarian Exaiptasia diaphana to investigate mechanisms linking prior heat stress to increased disease susceptibility. We examined anemone pathogen susceptibility and physiology (symbiosis, immunity, and energetics) following recovery from heat stress. We observed significantly increased pathogen susceptibility in anemones previously exposed to heat stress. Notably, prior heat stress reduced anemone energetic reserves (carbohydrate concentration), and activity of multiple immune components. Minimal effects of prior heat stress on symbiont density were observed. Together, results suggest changes in energetic availability might have the strongest effect on pathogen susceptibility and immunity following heat stress. The results presented here provide critical insight regarding the interplay between heat stress recovery and pathogen susceptibility in cnidarians and are an important first step towards understanding temporal associations between these stressors.
Assessment of lung function is an important clinical tool for the diagnosis and monitoring of chronic lung diseases, including idiopathic pulmonary fibrosis (IPF). In mice, lung function maneuvers use algorithm-based ventilation strategies including forced oscillation technique (FOT), negative pressure-driven forced expiratory (NPFE) and pressure-volume (PV) maneuvers via the FlexiVent system. This lung function test (LFT) is usually performed as end-point measurement only, requiring several mice for each time point to be analyzed. Repetitive lung function maneuvers would allow monitoring of a disease process within the same individual while reducing the numbers of laboratory animals. However, its feasibility in mice and impact on developing lung fibrosis has not been studied so far. Using orotracheal cannulation without surgical exposure of the trachea, we examined the tolerability to repetitive lung function maneuvers (up to four times) in one and the same mouse, both under healthy conditions and in a model of AdTGF-β1 induced lung fibrosis. In essence, we found that repetitive invasive lung function maneuvers were well tolerated and did not accentuate experimental lung fibrosis in mice. This study contributes to the 3R principle aiming to reduce the numbers of experimental animals used in biomedical research.
INTRODUCTION: Obesity is a growing public health concern affecting both children and adults. Since it involves both genetic and environmental components, the management of obesity requires both, an understanding of the underlying genetics and changes in lifestyle. The knowledge of obesity genetics will enable the possibility of precision medicine in anti-obesity medications.
AREAS COVERED: Here, we explore health complications and the prevalence of obesity. We discuss disruptions in energy balance as a symptom of obesity, examining evolutionary theories, its multi-factorial origins, and heritability. Additionally, we discuss monogenic and polygenic obesity, the converging biological pathways, potential pharmacogenomics applications, and existing anti-obesity medications - specifically focussing on the leptin-melanocortin and incretin pathways. Comparisons between childhood and adult obesity genetics are made, along with insights into structural variants, epigenetic changes, and environmental influences on epigenetic signatures.
EXPERT OPINION: With recent advancements in anti-obesity drugs, genetic studies pinpoint new targets and allow for repurposing existing drugs. This creates opportunities for genotype-informed treatment options. Also, lifestyle interventions can help in the prevention and treatment of obesity by altering the epigenetic signatures. The comparison of genetic architecture in adults and children revealed a significant overlap. However, more robust studies with diverse ethnic representation is required in childhood obesity.
1. Technical Result Widening of assortment of means for nourishing hair skin and hair roots and also for stimulation of hair growth. 2. Essence A cosmetic means for hair care comprises spirit extract of althaea roots Althaea officinalis, nettle Urtica urens, leaves of eucalyptus Eucalyptus, bulbs of garlic Allium sativum, roots of liquorice Glycyrriza glabra, St.-John's wort Hipericum perforatum L., leaves of birch Betula verricosa, bulbs of onion Allium cepa, surface parts of elder-berry Sambucus ebulus, bur-marigold Bidens tripartita, calendula Calendula officinalis, camphor spirit and flavoring. 3. Field of Application Cosmetology.
Ropivacaine injection. While looking at the Achilles tendon with ultrasound, the orthopaedic physician will inject 4 mL of 0.5% ropivacaine (numbing medicine) around the area of pain. The needle may be directed just under the skin (and above the tendon) and/or deep to the tendon.
Sepsis is a life-threatening condition caused by the body's response to an infection. Dapsone is a sulfone with antibiotic properties, and experimental evidence suggests it has significant anti-inflammatory and anti-oxidative stress effects. The objective of this study was to investigate the efficacy of dapsone in mice after CLP (cecal ligation and puncture) surgery, which is a model for inducing sepsis. The study divided animals into five groups: CLP, sham, and three groups receiving different doses of dapsone (0.5, 1, 2 mg/kg). Sepsis was induced through CLP surgery, followed by dapsone administration. In each group, half of the mice were used to evaluate levels of various markers and pathological changes at 24 h post-CLP, while the other half was used to record the mortality rates within 96 h. The results showed that single-dose administration of dapsone at (0.5, 1, 2 mg/kg) after CLP surgery improved survival compared to the CLP group. Dapsone was also associated with a significant reduction in pro-inflammatory cytokines TNF-α, IL-1β, IL-6, NO, and MPO, as well as lactate and creatinine serum levels. However, dapsone did not have a significant effect on urea serum levels. In conclusion, the data suggest that dapsone treatment leads to increased survival in septic mice after CLP, and due to its ability to reduce TNF-α, IL-1β, IL-6, MPO, and lactate levels, it has anti-inflammatory effects in sepsis. The sepsis treatment with dapsone in mice protects against inflammation and oxidative stress.
A product comprising as its main components henna and cocoa butter with the product having a solid form. Also a method of forming a solid form product comprising the step of mixing henna and cocoa butter to form a paste and allowing the paste to harden. Additives may be provided, such as a surfactant, a conditioning agent, a fragrance, a herb, a fruit extract, a vegetable, a natural way or butter, a synthetic wax, a humectant, glycerine, a vegetable oil. Preferably the product is formed of 40 % to 90 % henna by weight and 10 % to 60 % cocoa butter by weight. More preferably the product is formed of 60 % to 80 % henna by weight and 20 % to 40 % cocoa butter by weight. Most preferably the product is formed of 70 % henna by weight and 30 % cocoa butter by weight.
Ischemic stroke is a leading cause of human mortality. Cerebral ischemia-reperfusion injury (CI/RI) is a primary cause of stroke. Ischemia-reperfusion (I/R) resulting in oxidative stress and inflammatory events may lead to severe neuronal impairments. Thus, anti-oxidative and anti-inflammatory mediators that can alleviate post-I/R neuronal injuries are required for the treatment of CI/RI. An alkaloid, voacangine (VCG) is a recognized antioxidant, anti-inflammatory, and anticancer agent. Hence, the current study intended to explore the neuroprotective potential and the principal mechanisms of VCG in CI/RI. The experimental rats were divided into four sets: control, I/R-induced, I/R + VCG (2.5 mg/kg), I/R + VCG (5 mg/kg). CI/RI was induced by implanting a thread into the middle cerebral artery occlusion (MCAO) model. Brain damages were assessed on the basis of brain edema, brain infarct volume, neurological deficit score, histopathology, oxidative stress, and neuroinflammation. Results revealed that VCG inhibited the triggering of NLRP3 inflammasome, pro-inflammatory cytokines, lipid peroxidation, but enhanced the antioxidant status in MCAO rats. Furthermore, VCG treatment averted brain damage by I/R, neuroinflammation, and oxidative stress by suppressing NF-κBp65/MAPK pathways. The results of the study provide pertinent insights pertaining to the role of VCG as a potential neuroprotective agent against ischemic stroke.
The invention comprises a gastric device having a pouch formed from a degradable film. Preferably, the pouch contains a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.
Human or animal bones are used to house and nurture other useful tissues. Once inside the bones, the transferred cells may become attached to the bone, and the blood vessels within the bone provide nutrition. The transferred cells or tissues can be injected as a solution of individual cells or small clumps of cells. Large numbers of cells supported with an extracellular matrix scaffold can be surgically implanted or injected. The extracellular matrix can be synthetic, resorbing, or derived from biologic sources. To assist with transfer, the cells or tissue may be contained in a bag before being placed in the bone. The non-bone materials may either be removed from the bone following sufficient growth and nourishment, or the biologic materials may remain in place to provide one or more desirable functions. For example, a bone's access to the blood stream should help the islet cells monitor blood glucose, and release insulin into the blood stream.
To decrease the interference in the process of epileptic feature extraction caused by insufficient detection capability in partial channels of focal epilepsy, this paper proposes a novel epilepsy detection method based on dynamic electroencephalogram (EEG) channel screening. This method not only extracts more effective epilepsy features but also finds common features among different epilepsy subjects, providing an effective approach and theoretical support for across-subject epilepsy detection in clinical scenarios. Firstly, we use the Refine Composite Multiscale Dispersion Entropy (RCMDE) to measure the complexity of EEG signals between normal and seizure states and realize the dynamic EEG channel screening among different subjects, which can enhance the capability of feature extraction and the robustness of epilepsy detection. Subsequently, we discover common epilepsy features in 3-15 Hz among different subjects by the screened EEG channels. By this finding, we construct the Residual Convolutional Long Short-Term Memory (ResCon-LSTM) neural network to accomplish across-subject epilepsy detection. The experiment results on the CHB-MIT dataset indicate that the highest accuracy of epilepsy detection in the single-subject experiment is 98.523 %, improved by 5.298 % compared with non-channel screening. In the across-subject experiment, the average accuracy is 96.596 %. Therefore, this method could be effectively applied to different subjects by dynamically screening optimal channels and keep a good detection performance.