anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
All patients will undergo laparoscopic cholecystectomy. In the third group intraoperative cholangiography will be performed with direct administration of indocyanine green at a dose of 0.03 mg / ml / Kg to the bile duct cyst.
The process comprises intramolecular cyclising of a beta-aminoacrylate deriv. using as reaction medium an inert solvent in the presence of a base at a temp. of 20-150 deg.C. With aliphatic alcohols, ethers etc. as solvent and metal hydroxides or (bi)carbonates as base, the reaction is carried out with protection of the amino gp. of the beta-amino acrylate. The resulting ester is treated to eliminate the protector gp. of the amino substituent. - The cyclised prod. can be hydrolysed in the presence of an inorganic acid or a hydroxide giving carboxylic acid which can be converted into one of its salts.
The prepn. of coronary active 1, 4-dihydro-pyridines (I) in sorbed form contg. polyacrylate powder comprises dissolving or dispersing polyacrylate in a soln. of (I) in an organic solvent which is miscible with water and adding so much water that (I) is at least partially pptd. out on and/or in the dispersed polyacrylate particles or in the polyacrylate particles which form in the solvent/water mixt.; so that the resulting pseudo latex can be converted into a dry powder by sepn. of the liq. phase. USE/ADVANTAGE - Coronary active (I), such as Nifedipin (1, 4-dihydro-2, 6- dimethyl-4-(2'-niphophenyl-3, 5-pyridine dicarboxylic acid dimethyl ester) can be used to treat disorders of the heart and circulation and to treat hypertonia. The (I) fixed on polyacrylate particles according to the invention are of high bioavailability with an excellent initial steep increase in plasma concn., with an initial peak lower than that given by conventional formulations but a level after 24 hrs which is markedly higher.
The children in the control group only receive treatment-as-usual (TAU) and the parents do not have an active app during the main intervention period of 20 weeks. TAU includes lifestyle behaviour counselling, dietary counselling by specialized dieticians, prescriptions for physiotherapy, as provided at the last clinical visit.
Although Stereotactic radiosurgery (SRS) is utilized as an effective treatment method, after several months to over 1 year following SRS, 33% of treated brain metastases increase in size on imaging, which is suspicious for tumor progression. However, based on findings in follow-up biopsies, the majority of newly detected metastases on imaging are radiation treatment effects instead of active tumor. So far, the only gold standard to differentiate active tumor and radiation necrosis is surgical resection for pathologic confirmation, which is invasive, not favored for poor surgical candidates, and should be avoided in cases of necrosis. The existing clinical imaging techniques have poor sensitivity or specificity in differentiating these two types of tissues. Recently, a novel MRI data acquisition approach, namely MR Fingerprinting (MRF), has been introduced for the simultaneous measurement of multiple important parameters in a single MRI scan. In addition, quantitative diffusion MRI, such as the intravoxel incoherent motion (IVIM) technique, can provide a noninvasive and powerful tool to quantify microstructural information by measuring water diffusion and microcirculation perfusion in vivo. This study aims to demonstrate the clinical feasibility of combining MRF with state-of-the-art parallel imaging techniques to achieve high-resolution quantitative imaging within a reasonable scan time of 5 min for whole brain coverage. It also aims to apply the developed quantitative approach in combination with IVIM MRI for the differentiation of tumor recurrence and radiation necrosis. The multi-parametric quantitative measures developed in this study could establish a new fundamental biomarker for the diagnosis and monitoring of brain tumors
Anabolic steroids are synthetic derivatives of testosterone. Certain clinical effects and adverse reactions demonstrate the androgenic properties of this class of drugs. Complete dissociation of anabolic and androgenic effects has not been achieved. The actions of anabolic steroids are therefore similar to those of male sex hormones with the possibility of causing serious disturbances of growth and sexual development if given to young children. Anabolic steroids suppress the gonadotropic functions of the pituitary and may exert a direct effect upon the testes.

During exogenous administration of anabolic androgens, endogenous testosterone release is inhibited through inhibition of pituitary luteinizing hormone (LH). At large doses, spermatogenesis may be suppressed through feedback inhibition of pituitary follicle-stimulating hormone (FSH).

Anabolic steroids have been reported to increase low-density lipoproteins and decrease high-density lipoproteins. These levels revert to normal on discontinuation of treatment.

In a single dose pharmacokinetic study of Oxandrin in elderly subjects, the mean elimination half-life was 13.3 hours. In a previous single dose pharmacokinetic study in younger volunteers, the mean elimination half-life was 10.4 hours. No significant differences between younger and elderly volunteers were found for time to peak, peak plasma concentration or AUC after a single dose of Oxandrin. The correlation between plasma level and therapeutic effect has not been defined.
PURPOSE: The risk factors for excessive blood loss and transfusion during total knee arthroplasty (TKA) remain unclear. The present study aimed to determine the risk factors for excessive blood loss and establish a predictive model for postoperative blood transfusion.
METHODS: This retrospective study included 329 patients received TKA, who were randomly assigned to a training set (n = 229) or a test set (n = 100). Univariate and multivariate linear regression analyses were used to determine risk factors for excessive blood loss. Univariate and multivariate logistic regression analyses were used to determine risk factors for blood transfusion. R software was used to establish the prediction model. The accuracy and stability of the models were evaluated using calibration curves, consistency indices, and receiver operating characteristic (ROC) curve analysis.
RESULTS: Risk factors for excessive blood loss included timing of using a tourniquet, the use of drainage, preoperative ESR, fibrinogen, HCT, ALB, and free fatty acid levels. Predictors in the nomogram included timing of using a tourniquet, the use of drainage, the use of TXA, preoperative ESR, HCT, and albumin levels. The area under the ROC curve was 0.855 (95% CI, 0.800 to 0.910) for the training set and 0.824 (95% CI, 0.740 to 0.909) for the test set. The consistency index values for the training and test sets were 0.855 and 0.824, respectively.
CONCLUSIONS: Risk factors for excessive blood loss during and after TKA were determined, and a satisfactory and reliable nomogram model was designed to predict the risk for postoperative blood transfusion.
The coronaridine congeners catharanthine and 18-methoxycoronaridine (18-MC) display sedative, anxiolytic, and antidepressant properties by acting on mechanisms involving GABAergic and/or monoaminergic transmissions. Here, we expanded their pharmacological properties by studying their anticonvulsant activity in male and female mice using the pentylenetetrazole (PTZ)-induced seizure test. To determine potential neurochemical mechanisms, the effect of congeners on monoamine content and kainic acid (KA)-induced epileptiform discharge was studied in the hippocampus. The behavioral results showed that coronaridine congeners induce acute anticonvulsant activity in a dose-dependent but sex-independent manner. Repeated treatment with a subthreshold dose (20 mg/kg) of each congener produced anticonvulsant activity in a sex-independent manner, but was significantly higher in male mice when compared to its acute effect. Using a behaviourally relevant regimen, we found that PTZ increased dopamine metabolites and serotonin tissue content. Coronaridine congeners, which induced distinct effects on monoamines, blunted the effect of PTZ instead of potentiating it, suggesting the existence of another mechanism in their anticonvulsant activity. The electrophysiological results indicated that both congeners inhibit KA-induced epileptiform discharges in hippocampal slices. A key aspect of this study is that the activity of both congeners was observed only in the presence of GABA, supporting the notion that hippocampal GABAAR potentiation plays an important role. Our study showed that coronaridine congeners induce acute anticonvulsant activity in a sex-independent manner. However, a comparatively higher susceptibility was observed in male mice after repeated treatment. The underlying hippocampal mechanisms mainly involve GABAAR potentiation, whereas monoamines play a minor role in the anticonvulsive action.
PURPOSE:To enable diagnosis of human papilloma virus(HPV) infectious diseases by culturing and proliferating a hybridoma prepared by fusing a specific splenic cell to a mouse myelomatous cell. CONSTITUTION:An HPV1 type is treated with an alkali at pH10-11 to provide an antigen, which is then administered to immunize a BALB/c mouse. The spleen thereof is then subjected to extirpation treatment to afford an antibody- producing splenic cell (A), which is subsequently mixed with a myelomatous cell (B) derived from a mouse at (1-20):1 ratio and cultured in a microplate well to provide a hybridoma group. The resultant group is then cloned to afford a hybridoma (C) capable of producing an antihuman papilloma virus monoclonal antibody (KI H8). The component (C) is subsequently cultured in a culture medium containing bovine fetal blood serum at about 37 deg.C in a CO2-containing air atmosphere for 10-14 days to provide a culture supernatant, which is then purified to produce the above-mentioned monoclonal antibody. The component (C), as necessary, is proliferated in a mouse abdominal cavity and an antibody is subsequently separated and recovered from the resultant mouse ascitic fluid.
Patients will receive 2,000 impulses of extracorporeal radial shockwave per week, with pressure of 2.5bar to 4.0bar, at the frequency of 8Hz. The impulses will be applied at the most painful site of the knee joint interface on manual palpation, for three consecutive weeks.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: present invention refers to an oral pharmaceutical composition taken between meals for phosphorous compounds absorption from the intestinal liquids, especially from saliva. The composition contains a phosphorus binding agent, and a pharmaceutically acceptable carrier and/or an excipient. The composition is kept in a mouth to exhaust the phosphorus binding agent. The phosphorus binding agent represents a phosphate binding agent polymer, a pharmaceutically acceptable lanthanum salt, a pharmaceutically acceptable magnesium salt, a pharmaceutically acceptable calcium salt, a pharmaceutically acceptable anion-exchange resin, a pharmaceutically acceptable phosphate binding polysaccharide. Preferentially, the agent represents phosphate binding chitosan. The composition is used for treating hyperphosphatemia. ^ EFFECT: invention provides effective treatment of high blood serum phosphorus concentration and reduces risk of cardiovascular complications in patients. ^ 19 cl, 2 tbl, 2 ex
OBJECTIVE: Catatonia is a syndrome that can be missed in clinical settings. Diagnosis of catatonia is important because the condition can be reversible and is associated with severe complications. This study aims to screen patients with catatonia admitted to a university hospital's psychiatry and neurology services, examine their characteristics, and compare the coverage of different catatonia scales.
METHOD: During a consecutive 20 months study period, the Turkish adaptations of the Bush-Francis Catatonia Rating and the KANNER scales were administered in psychiatry and neurology inpatient units and patients on the waiting list for psychiatric hospitalization. The participants were also evaluated with DSM-5 criteria. In addition, the sociodemographic and clinical characteristics of the patients in the psychiatric group were compared.
RESULTS: A total of 214 patients were evaluated. Twenty-eight (13.1%) screened positive for catatonia, and 23 (82.1%) were diagnosed with catatonia according to DSM-5 criteria. KANNER and Bush- Francis identified the same patients as having catatonia. In addition to schizophrenia and mood disorders; neurodevelopmental disorder, encephalitis, postpartum psychosis, obsessive-compulsive disorder, delirium, cerebrovascular disease, functional neurological symptom disorder have also been found to be associated with catatonia. The most common complication was urinary tract infection. Life-threatening complications were also observed.
CONCLUSION: Overlooking catatonia may have dire consequences. Adhering solely to the DSM-5 criteria may miss some patients with catatonia. Widely and efficiently using standardized catatonia scales can improve detection capacity and enhance the management of morbidity and mortality.
Reductions in bone mineral density (BMD) over time are seen with exemestane use. Table 1 describes changes in BMD from baseline to 24 months in patients receiving exemestane compared to patients receiving tamoxifen (IES) or placebo (027). Concomitant use of bisphosphonates, vitamin D supplementation, and calcium was not allowed.

Table 1. Percent Change in BMD from Baseline to 24 months, Exemestane vs. Control1

During adjuvant treatment with exemestane, women with osteoporosis or at risk of osteoporosis should have their bone mineral density formally assessed by bone densitometry at the commencement of treatment. Monitor patients for bone mineral density loss and treat as appropriate.
PURPOSE:To conduct quantitative and objective pack material evaluation by measuring immunoglobulin in saliva. CONSTITUTION:Secretory immunoglobulin A among immunoglobulin in saliva is easily secreted in external liquid such as saliva, and a specimen can be easily gathered, and this concentration and a desirable effect exerted by a pack excellently correlate with each other. Therefore, it is preferable as an index. For example, as a measuring method, there is an antibody method and oxygen, a radioactive substance, a fluorescence dye or the like are used as a labelling substance of an antibody, and the quantity of an antigen is measured from a bonding quantity of an anti-immunoglobulin antibody bonding to immunoglobulin of an antigen. When an anti-secretory immunoglobulin antibody is used as this antibody, the secretory immunoglobulin can be specifically quantitatively determined. Therefore, the concentration of the immunoglobulin raised by a pack effect is measured, and the quality of a pack material can be judged from a concentration raising degree. Therefore, since an evaluating reference is a continuous figure like concentration, quantitative and objective evaluation becomes possible.
The invention relates to a traditional Chinese medicine preparation for treating heart cerebrovascular diseases, which comprises the following components in percentage by weight: 15-25 percent of bletilla striata, 15-25 percent of motherwort herb, 10-20 percent of szechuan lovage rhizome, 10-20 percent of raidx astragali, 10-20 percent of raw panax pseudoginseng, 8-12 percent of raw hawthorn, 10-20 percent of salvia przewalskii, 10-20 percent of ginkgo leaf, 8-12 percent of Guiwei, 8-12 percent of radix achyranthis bidentatae, 8-12 percent of radix angelicae and 8-12 percent of callicarpa bodinieri. The traditional Chinese medicine preparation can be prepared into powder, tablets, pills and capsules. A preparation method of the traditional Chinese medicine preparation comprises the following steps: pulverizing, sieving and sterilizing the medicinal components into the powder and preparing the prepared powder into the tablets, the pills and the capsules; or preparing the medicinal components into water-decocted liquid, preparing the water-decocted liquid into oral liquid; drying, pulverizing, sieving and sterilizing the water-decocted liquid into the powder; and preparing medicinalgranules or the capsules by using the prepared powder. The preparation method of honeyed pills comprises the following steps: pulverizing and sieving the medicinal components; refining honey and adding water to dissolve; filtering, and adding the honey to medicinal powder to prepare the honeyed pills. The traditional Chinese medicine preparation has obvious curative effect on treating various symptoms caused by coronary diseases, hypertension and cerebral thrombosis and the heart cerebrovascular diseases of headaches, dizziness, and the like caused by cerebral circulation insufficiency. The invention is prepared from pure traditional Chinese medicines, has convenient use, safety, reliability and no poisonous and side effect and can be taken for a long time.
OBJECTIVE: We previously analyzed data from three phase lll trials of adjunctive brivaracetam (BRV) in adults showing that the incidence and prevalence of drug-related central nervous system treatment-emergent adverse events (TEAEs) quickly peaked and decreased over several weeks following BRV treatment initiation. However, that analysis did not assess psychiatric and behavioral side effects which can occur with antiseizure medication (ASM) treatment. Here, we investigate the time-course of psychiatric and behavioral TEAEs by week of BRV treatment and how these TEAEs were managed.
METHODS: Data were pooled from three trials (N01252 [NCT00490035]; N01253 [NCT00464269]; N01358 [NCT01261325]) in adult patients (≥16 years of age) with focal-onset seizures receiving BRV adjunctive therapy. This post hoc analysis reports data on the incidence and prevalence of drug-related psychiatric or behavioral TEAEs over time in patients who received BRV doses of 50-200 mg/day (without titration) or placebo (PBO) during the 12-week treatment period. A logistic regression model was used to determine if psychiatric or behavioral comorbid conditions were predictors for drug-related psychiatric or behavioral TEAEs, or BRV discontinuation due to psychiatric or behavioral TEAEs.
RESULTS: A total of 803 patients received BRV 50-200 mg/day, and 459 patients received PBO. Drug-related psychiatric or behavioral TEAEs were reported by 11.0 % of patients during adjunctive BRV treatment (PBO: 4.8 %) with onset early after BRV initiation (median time to onset of first drug-related psychiatric or behavioral TEAE: 15 days). Incidence peaked at week 1 and decreased over the first 4 weeks following BRV initiation. Prevalence peaked at week 4 and then remained stable between weeks 5-12. In an analysis excluding patients on concomitant levetiracetam (BRV: n = 744; PBO: n = 422), the incidence of drug-related psychiatric or behavioral TEAEs was similar to the incidence in the overall population. The most common drug-related psychiatric or behavioral TEAEs were irritability, insomnia, depression, and anxiety. Only 2 % of patients discontinued BRV due to psychiatric or behavioral TEAEs (PBO: 1.3 %), while most patients on BRV who reported drug-related psychiatric or behavioral TEAEs did not require a change in dose (84.1 %; PBO: 63.6 %). A history of psychiatric or behavioral comorbid conditions (not ongoing at BRV initiation) was not associated with an increased likelihood of drug-related psychiatric or behavioral TEAEs, or BRV discontinuation due to psychiatric or behavioral TEAEs. Ongoing psychiatric or behavioral comorbid conditions at BRV initiation increased the likelihood of drug-related psychiatric or behavioral TEAEs, but not the likelihood of BRV discontinuation due to psychiatric or behavioral TEAEs.
CONCLUSIONS: Drug-related psychiatric and behavioral TEAEs occurred early during BRV treatment, and most patients did not require a change in BRV dose. These data can help guide clinician monitoring and patient expectations after starting BRV.
Novel methods of injecting agents including cells into organs, tissues, or tumors using a side release needle and, optionally, a carrier that aids in retention of the cells at the injection site, or a tissue sealant or film to seal the injection site are provided. The use of side release needles and, optionally, a carrier, sealant, or film prevents the leakage of the injected agent back out of the injection site. Agents which maybe injected using the inventive method include drugs, small molecules, peptides, proteins, polynucleotides, viruses, cells, etc. Any type of cells including myoblasts may be used in the invention. The cells may be injected into any organ including the heart, brain, pancreas, liver, etc.. These injection methods may find use in tissue engineering, gene therapy, and tissue/organ repair. Kits with the side release needles used in carrying out the present invention are also provided.
Patients with autism have significant social difficulties and communication alterations. It has been shown in these patients difficulties to understand some clues indispensable to social relations, for example, faces and their emotions and motion of human bodies. The faces and human movements are an important source of information helping to interact with others. Understanding the intentions of the others through facial expressions and gestures can help them to adapt their behavior and their interactions. While in healthy subjects, faces and human movements receive special attention, autistic patients seem to pay less attention to this kind of social stimuli. It has already been shown that children and healthy adults spend more time looking at faces and human movements (relative to objects), whereas the opposite behavior is observed in patients with autism. Studying gaze behavior seems to be essential for progress in the understanding of autism pathology. Eye-tracking systems allow to measure precisely what a subject looks on a picture. Moreover, eye-tracking systems permit the measurement of the pupil size which variations are correlated with cognitive processes. The objective of this study is to analyze the ocular behavior (ocular scan path and pupil diameter) of young patients with autism when viewing faces and human movements and to compare these measurements with those of chronologically age-matched healthy children. This work will identify attentional problems concerning exploration of human faces and movements that can be related to their social difficulties. These disorders should be manifested by an atypical ocular scan path and by changes in pupil variation in response to face and human motion. Then to follow the evolution of these indices will allow to evaluate the effect of therapies. These results will highlight new data essential to understanding disorders of social relations and to better adapt rehabilitative strategies.
Participants who have currently received 800 to 1000 micrograms (μg) beclomethasone-equivalent inhaled corticosteroid (ICS) per day will receive budesonide/formoterol twice daily using the BF Spiromax 160/4.5 device. Therefore, the daily, ex-mouthpiece doses of budesonide and formoterol using BF Spiromax will be 640 μg and 18 μg, respectively. Participants who have currently received 1600 to 2000 μg beclomethasone-equivalent ICS per day will receive budesonide/formoterol twice daily using the BF Spiromax 320/9 μg device. Therefore, the daily, ex-mouthpiece doses of budesonide and formoterol using BF Spiromax will be 1280 μg and 36 μg, respectively.