anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Subject will receive GSK2140944 1000mg IV q12h (BID) on Day 1 and Day 2 . Subject may switch to GSK2140944 2000mg PO q12h (BID) at investigator's decision or will continue to receive GSK2140944 1000mg IV q12h (BID) from Day 3 to Day 10.
<P>PROBLEM TO BE SOLVED: To contribute to audit for the amount of medicines having the same component to be prescribed to a patient, and audit whether a prescription order is suitable to the state of the patient or not.  <P>SOLUTION: Medicine item data including administration units stored in a unit conversion master 107 is retrieved to specify administration units of medicine items, administration unit conversion data including conversion coefficients for converting medicine names shown in medicine data and the dosage of medicines shown in a prescription order to dosage of administration units shown in medicine item data stored in a medicine item master 108 is retrieved. Based on the specified administration units, the daily dosage of each medicine item is calculated to generate display data for the calculated daily dosage of every medicine item. The daily dosage is adjusted with a physical data coefficient based on the physical feature of the patient and a reference adjustment coefficient based on the clinical result of the patient to generate a final administration reference value. Further, a determination reference table for daily dosage is formed to determine whether the daily dosage of medicines are appropriate or not.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Local anesthetics (LA), as part of multimodal analgesia, have garnered significant interest for their role in delaying the initiation of opioid therapy, reducing postoperative opioid usage, and mitigating both hospitalization duration and related expenses. Despite numerous endeavors to extend the duration of local anesthetic effects, achieving truly satisfactory long-acting analgesia remains elusive. Drawing upon prior investigations, vesicular phospholipid gels (VPGs) emerge as promising candidates for extended-release modalities in small-molecule drug delivery systems. Therefore, we tried to use the amphiphilicity of phospholipids to co-encapsulate levobupivacaine hydrochloride and meloxicam, two drugs with different hydrophilicity, to obtain a long-term synergistic analgesic effect. Initially, the physicochemical attributes of the formulation were characterized, followed by an examination of its in vitro release kinetics, substantiating the viability of extending the release duration of the dual drugs. Sequentially, in vivo investigations encompassing pharmacokinetic profiling and assessment of analgesic efficacy were undertaken, revealing a prolonged release duration of up to 120 h and attainment of optimal postoperative analgesia. Subsequently, inquiries into the mechanism underlying synergistic analgesic effects and safety evaluations pertinent to the delivery strategy were pursued. In summation, we successfully developed a promising formulation to achieve long-acting analgesia.
Introduction: Congestive heart failure (CHF) patients suffer from early fatigue and functional aerobic impairment. Their reduced cardiac output and O2 delivery to the peripheral muscles shifts those patients consistent anaerobic metabolism, thus, CHF patients rely on anaerobic metabolism even in everyday life activity. This metabolism leads to a shift of muscles fiber types from mainly slow twitch, oxidative type I fibers to fast twitch, glycolytic type IIb fibers. Monocarboxylate proteins MCT1 and MCT4 transport lactate crosses the membrane. MCT1 is responsible for the lactate uptake and MCT4 is responsible for efflux of excess lactate. Exercise training is known to improve the quality of life in CHF. We hypothesized that exercise training might change MCT1 and 4 expression and distribution. Accordingly, these changes may also affect lactate clearance during recovery, which may contribute to the beneficial effect of exercise training in CHF patients. Methods: New-York Heart association (NYHA) class II-III CHF patients will be assigned to the experiment. At baseline and upon training conclusion they will undergo the same tests battery. The test battery includes heart rate, blood pressure measurements, echocardiographic evaluation. All participants will fill out "Minnesota living with heart failure" questionnaire. Subsequently, after their basal blood lactate will be assessed they will undergo measurement which will be followed by lactate clearance-rate evaluation.

Randomly each patient will then be assigned to one of two experimental training groups: (A) High intensity intervals training (HIT); (B) Continuous moderate aerobic training (MAT). Each volunteer will be trained twice a week for 12 weeks, according to his/hers assigned training protocol and in accordance to exercise training guidelines.
Subjects with nonalcoholic fatty liver disease (NAFLD) will complete baseline testing and then be assigned to either the high fructose corn syrup diet or the standard diet (low in high fructose corn syrup) for 4 weeks. Post intervention testing will be completed after the subjects have completed the 4 week diet intervention.
BACKGROUND: Guidelines must be interpreted comprehensively and correctly to standardize the clinical process. However, this process is challenging and requires interpreters to have a medical background and qualifications. In this study, the accuracy of ChatGPT3.5 in answering clinical questions related to the 2019 guidelines for severe acute pancreatitis was evaluated.
METHODS AND RESULTS: An observational study was conducted using the 2019 guidelines for severe acute pancreatitis. The study compared the accuracy of ChatGPT3.5 in English versus Chinese and found that it was more accurate in English (71%) than in Chinese (59%) (P value: 0.203). Additionally, the study assessed the accuracy of ChatGPT3.5 in answering short-answer questions versus true/false questions and found that it was more accurate in answering short-answer questions (76%) than in answering true/false questions (60%) (P value: 0.405).
CONCLUSIONS: For clinicians managing severe acute pancreatitis, ChatGPT3.5 may have potential value. However, it should not be relied upon excessively for clinical decision making.
<P>PROBLEM TO BE SOLVED: To provide a food for preventing pollinosis, utilizing orchardgrass.  <P>SOLUTION: Stems and leaves of the orchardgrass of 250 g, reaped at the end of August after the finish of the bloom, and preserved after drying, and stems and leaves of Equisetum arvense of 250g are put in water of 5 L, and boiled at about 98°C for 2 hr. The extracted liquid after boiling is poured into a bottle, and administered to a testee by 180 mL at three times of morning, daytime and evening. After continuing the administration for 1 month, the symptom such as nasal congestion, snot, sneeze, swelling and bleeding of the tonsil, and headache in spring, summer and autumn caused by the pollinosis and continued for 30 years is ameliorated to a degree of not feeling the symptom. In comparison, the leaves of the Equisetum arvense of 500g are put in the water of 5 L, and boiled at about 98°C for 2 hr. The extracted liquid after boiling is poured into a bottle, and administered to a testee by 180 mL at three times of morning, daytime and evening. After continuing the administration for three years, a diuretic activity is observed but the symptom of the pollinosis is not changed.  <P>COPYRIGHT: (C)2004,JPO&NCIPI
PURPOSE OF REVIEW: To describe current and future strategies to reduce the burden of ovarian cancer through prevention.
RECENT FINDINGS: Current strategies in genetic testing are missing a substantial number of individuals at risk, representing a missed opportunity for ovarian cancer prevention. Past efforts at screening and early detection have thus far failed to improve ovarian cancer mortality, and novel techniques are needed. Surgical prevention is highly effective, but surgical menopause from oophorectomy has significant side effects. Novel surgical strategies aimed at reducing risk while minimizing these harms are currently being studied. To maximize ovarian cancer prevention, a multi-pronged approach is needed. We propose that more inclusive and accurate genetic testing to identify more individuals at risk, novel molecular screening and early detection, surgical prevention that maximizes quality of life while reducing risk, and broader adoption of targeted and opportunistic salpingectomy will together reduce the burden of ovarian cancer.
A Chinese traditional medicine composition for prevention and treatment of avian influenza is provided. Its activated ingredients are consisted of:  herba houttuyniae  21.4 wt. %,  Caulis lonicerae japonicae  17.9 wt. %,  radix isatidis  14.3 wt. %,  male fern rhizome  10.7 wt. %,  radix et rhizoma sophorae tonkinensis  7.1 wt. %,  radix angelicae dahuricae  7.1 wt. %,  rhizoma paridis  7.l wt. %,  herba artemisiae annuae  7.2 wt. %, and  rhizoma iridis tectoris  7.2 wt. %. This Chinese traditional medicine composition could be made into any regular medicinal types, for example, oral solutions, tablets, capsules, pellets and injection solution, etc. Modified preparation methods for this Chinese traditional medicine composition, as well as the use of the same in preparation of medicines and health foods for prevention or treatment of avian influenza were also provided in present invention. This Chinese traditional medicine composition could effectively prevent and treat avian influenza. It was a safer, more easily-obtained, and inexpensive anti-avian influenza drug.
General symptomatic and supportive measures should be used, along with immediate gastric lavage where appropriate. Intravenous fluids should be administered as needed. As in all cases of drug overdose, respiration, pulse, blood pressure, and other appropriate vital signs should be monitored, and general supportive measures employed.

Hemodialysis does not effectively reduce exposure to ramelteon. Therefore, the use of dialysis in the treatment of overdosage is not appropriate.

Poison Control Center   
As with the management of all overdosage, the possibility of multiple drug ingestion should be considered. Contact a poison control center for current information on the management of overdosage.
Patients receive oral exemestane once daily and oral sunitinib malate once daily on days 1-28. Treatment repeats every 4 weeks for 6 courses in the absence of disease progression or unacceptable toxicity.
BACKGROUND: Obesity, a multifactorial and complex health condition, has emerged as a significant global public health concern. Integrating machine learning techniques into obesity research offers great promise as an interdisciplinary field, particularly in the screening, diagnosis, and analysis of obesity. Nevertheless, the publications on using machine learning methods in obesity research have not been systematically evaluated. Hence, this study aimed to quantitatively examine, visualize, and analyze the publications concerning the use of machine learning methods in obesity research by means of bibliometrics.
METHODS: The Web of Science core collection was the primary database source for this study, which collected publications on obesity research using machine learning methods over the last 20 years from January 1, 2004, to December 31, 2023. Only articles and reviews that fit the criteria were selected for bibliometric analysis, and in terms of language, only English was accepted. VOSviewer, CiteSpace, and Excel were the primary software utilized.
RESULTS: Between 2004 and 2023, the number of publications on obesity research using machine learning methods increased exponentially. Eventually, 3286 publications that met the eligibility criteria were searched. According to the collaborative network analysis, the United States has the greatest volume of publications, indicating a significant influence on this research. coauthor's analysis showed the authoritative one in this field is Leo Breiman. Scientific Reports is the most widely published journal. The most referenced publication is "R: a language and environment for statistical computing." An analysis of keywords shows that deep learning, support vector machines, predictive models, gut microbiota, energy expenditure, and genome are hot topics in this field. Future research directions may include the relationship between obesity and its consequences, such as diabetic retinopathy, as well as the interaction between obesity and epidemiology, such as COVID-19.
CONCLUSION: Utilizing bibliometrics as a research tool and methodology, this study, for the first time, reveals the intrinsic relationship and developmental pattern among obesity research using machine learning methods, which provides academic references for clinicians and researchers in understanding the hotspots and cutting-edge issues as well as the developmental trend in this field to detect patients' obesity problems early and develop personalized treatment plans.
Hair is permanently waved by treating it with an agent which breaks the-S-S-bands of the keratin, constraining the hair to a desired configuration and then treating it with an aqueous solution buffered to a pH between 7 and 11 and containing polythionate ions.  The weight ratio of the buffering agent to the polythionate is preferably from 3:20 to 7:20.  Suitable buffering agents are borax, sodium glycollate ammonium carbonate, sodium glycinate, disodium phosphate, a mixture of boric acid and borax, a mixture of citric acid and disodium phosphate and a mixture of sodium carbonate and sodium bicarbonate.  The polythianate specified are potassium trithianate, and pentathionate.  The neutralizing solution may also contain surface active agents, cholesterol, lanolin and silica gel. Specified reducing agents used to break the-S-S-bands of the keratin are aqueous solutions of ammonium thioglycollate, thiolactio acid, a hercapto acetamide or the ammonium salt of b  inercapto propianic acid which may also contain ammonia and ammonium sequicarbonate.
FIELD: medicine.SUBSTANCE: invention relates to means for neonatal assistance and paediatrics. An orogastric or nasogastric feeding tube contains a tubular constructive element, forming, at least, one element with an orifice, forming a channel for the supply of feeding from outside into the stomach or the subject's small intestine and including one of a moulded or made with an envelope assembly unit from separate components, including the orifice-provided element, wires, electromechanical components, wires, applied on the central element with the orifice, which is obtained by multicomponent moulding, casting or is encapsulated after the application of moulded in a wall wires in an obtained by extrusion profile with one orifice or with a multitude of orifices or a braid of separate wires, placed in one of the multitude of orifice-provided elements. The multitude of orifice-provided elements physically separates the feeding-supplying channel in one of the orifice-provided elements from electromechanical components. Three electrodes for ECG reading are located with equal or unequal intervals from the external side of the tube for determining parameters of the subject's heart activity. Means, realising an algorithm of monitoring for the selection of one of the subsets of three electrodes, provides an optimal signal of the heart activity measurement basing on the measured heart activity. The tube additionally contains at least one of an oropharyngeal thermistor in the zone of the subject's pharynx, a hypopharyngeal thermistor for monitoring the subject's temperature below the subject's pharynx or an oesophageal thermistor for monitoring the subject's internal temperature. The method consists in the introduction of the feeding tube into the subject's oesophagus, moving it to a place, planned for the placement of a tip in the selected place in the subject's stomach or small intestine, reading the heart activity by the subsets of three electrodes, processing of the read signal forms for comparison, analysis and selection of the subset of electrodes, which have an optimal read signal of the heart activity to detect equipotential cardiologic signals for continuous monitoring of the subject's heart activity and realisation of monitoring of the subject's respiration signal or temperature in the zone of the subject's pharynx or monitoring the subject's temperature below the pharynx.EFFECT: application of the invention makes it possible to increase the accuracy of the tube installation.11 cl, 5 dwg
BACKGROUND: Migraine has a strong genetic foundation, including both monogenic and polygenic types. The former are rare, with most migraine considered polygenic, supported by genome-wide association studies (GWAS) identifying numerous genetic variants linked with migraine risk. Surprisingly, some of the most common mutations are associated with transient receptor potential melastatin 8 (TRPM8), a non-selective cation channel that is the primary sensor of cold temperatures in cutaneous primary afferents of the somatosensory system. However, it is unlikely that the temperature sensitivity of TRPM8 is relevant in migraine-related tissues, such as the meninges, suggesting other activation mechanisms underly its role in migraine pathogenesis. Thus, to define the basis of the channel's involvement, we reasoned that cellular processes that increase cold sensitivity in the skin, such as the neurotrophic factor artemin, via its receptor glial cell-line derived neurotrophic factor family receptor alpha-3 (GFRα3), also mediate TRPM8-associated migraine-like pain in the meninges.
METHODS: To investigate the role of artemin and GFRα3 in preclinical rodent migraine models, we infused nitroglycerin acutely and chronically, and measured changes in periorbital and hind paw mechanical sensitivity in male and female mice lacking GFRα3, after neutralization of free artemin with specific monoclonal antibodies, or by systemic treatment with a TRPM8-specific antagonist. Further, in mice lacking GFRα3 we tested the effects of supradural infusions of a mix of inflammatory mediators, as well as tested if dura stimulation with artemin or a TRPM8-specific agonist induce migraine-related pain in mice.
RESULTS: We find that mechanical allodynia induced by systemic nitroglycerin, or supradural infusion of inflammatory mediators, involves GFRα3. In addition, neutralization of circulating artemin reduces the nitroglycerin phenotype, demonstrating the importance of this neurotrophic pathway in headaches. Further, we show TRPM8 expression in the meninges, and that direct supradural infusion of either a TRPM8-specific agonist or artemin itself produces mechanical allodynia, with the latter dependent on TRPM8 and ameliorated by concurrent treatment with sumatriptan.
CONCLUSIONS: These results indicate that neuroinflammatory events in the meninges can produce migraine-like pain in mice via artemin and GFRα3, likely acting upstream of TRPM8, providing a novel pathway that may contribute to headaches or migraine pathogenesis.
Medical preparation for the treatment of hepatic dysfunctions, and method of obtaining it, consisting of a liquid consisting of condensed vapor obtained from the boiling of a mixture that, for 200 g of liquid, includes: washing with water and 6 drops of tamarºn {reg}, 2 kilos dry tomato leaves, their incorporation drained, in a pressure cooker with 50 g of peach leaves and 50 g of tamarind leaves; 8 grams of sulfur and 25 gr. Of alcohol of 96º to undo the sulfur and 2 liters of distilled or rain water. When boiling, the steam comes out through a rubber, whose opposite end communicates with a transparent container that collects the steam. The obtained liquid is filtered through its casting through a transparent paper, to eliminate impurities. From the pot, the liquid residue that has been left in it is married, to be used equally as a healing remedy. (Machine-translation by Google Translate, not legally binding)
PURPOSE: An increase method of fused protein into living cells or organs by adding pergolide to fused protein in which protein transport domains and therapeutic protein are covalently bonded is provided to drastically enhance infiltration efficiency of the fused protein. CONSTITUTION: An increase method of fused protein into living cells or organs is processed by adding pergolide to fused protein in which protein transport domains and therapeutic protein are covalently bonded. The pergolide is primarily processed in the living cells or organs than the fused protein. A protein transport domain is Tat, PEP-1, oligolysine, oligo arginine or oligo(lysine and arginine). The pergolide is pergolide mesylate. The therapeutic protein is an enzyme which removes the active oxygen species. The therapeutic protein is catalase, superoxide dismutase or glutathione peroxidase. A composition for preventing and treating disease due to oxidative stress and inflammatory diseases comprises the fused protein and pergolide of the enzyme having the active oxygen species.
Disclosed are diagnosis and treatment integrated manganese oxide protein nanoparticles, a preparation method therefor, and use thereof. The manganese oxide protein nanoparticles are successfully prepared using a one-step preparation method for the first time. The prepared nanoparticles are uniformly dispersed and have a uniform particle size. The nanoparticles have the dual response characteristics of acidity and a reducing environment, with its relaxation coefficient induced to be exponentially increased to 7.8mM -1s-1. Meanwhile, the nanoparticles can activate an innate immune pathway and induce a photothermal effect, making the nanoparticles have such tumor treatment functions as photothermal therapy and immunotherapy of tumors. The provided manganese oxide protein nanoparticles have the remarkable advantages of being prepared using a simple and convenient process, being uniform in size, being controllable in particle size, having good biocompatibility, targeting tumors well, having strong contrast performance, and having diverse treatment modes and the like, thereby laying a foundation for efficient tumor treatment and accurate tumor diagnosis.
The invention provides a fusion protein, which sequentially comprises the following components from an N end to a C end: the SEC2 mutant comprises a SEC2 mutant, a connecting short peptide and an iNGR, wherein the SEC2 mutant is mutated at the amino acid residues at the 20 th, 22 th, 118 th and/or 122 th positions of the sequence shown in SEQ ID NO. 18, the amino acid sequence of the connecting short peptide is shown in SEQ ID NO. 4, and the amino acid sequence of the iNGR is shown in SEQ ID NO. 5. The invention also provides a preparation method and application of the fusion protein. The targeting fusion protein can specifically target and infiltrate into a tumor tissue microenvironment, greatly improves the tumor specificity and vascular permeability of the superantigen, and improves the killing efficiency on tumors, so that the survival capability of patients can be effectively improved when the targeting fusion protein is used for treating the patients, and the targeting fusion protein has good clinical application value.
<P>PROBLEM TO BE SOLVED: To provide more effective anti-HCV therapy.  <P>SOLUTION: There are provided compounds that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. These compounds act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. There are further provided compositions containing these compounds either for ex vivo use or for administration to a patient suffering from HCV infection. There are also provided methods of treating an HCV infection in a patient by administering a composition containing a compound. There are further provided processes for preparing these compounds.  <P>COPYRIGHT: (C)2011,JPO&INPIT