anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
INTRODUCTION: Musculoskeletal (MSK) injuries and associated pain disorders are one of the leading causes for soldiers not being medically fit for deployment, impacting force capability and readiness. Musculoskeletal pain continues to be a leading cause of disability within military services and is associated with a substantial financial burden. A better understanding of the effectiveness of MSK pain management strategies is required. This review was designed to determine the efficacy of nonsurgical interventions, such as physiotherapy, exercise, pharmacology, and multidisciplinary programs, to manage MSK conditions in active serving military populations.
MATERIALS AND METHODS: MEDLINE, Embase, CINAHL, and SPORTDiscus were searched to identify relevant randomized clinical trials. Recommended methods were used for article identification, selection, and data extraction. The Cochrane Risk of Bias tool and the Grade of Recommendation, Assessment, Development, and Evaluation were used to appraise the studies. Where possible, meta-analyses were performed. The review was conducted according to the PRISMA guidelines.
RESULTS: Nineteen articles (1,408 participants) met the eligibility criteria. Low back pain (LBP) was the most frequently investigated condition, followed by knee pain, neck pain, and shoulder pain. Early physiotherapy, exercise and adjunct chiropractic manipulation (for LBP), and multidisciplinary pain programs (physiotherapy, occupational therapy, and psychology) (for chronic MSK pain) improved pain (standardized mean difference ranged from -0.39 to -1.34; low strength of evidence). Participation in multidisciplinary pain programs, adjunct chiropractic manipulation, and early physiotherapy improved disability (for LBP) (standardized mean difference ranged from -0.45 to -0.86; low to very low strength of evidence). No studies evaluated pain medication. Dietary supplements (glucosamine, chondroitin sulfate, and manganese ascorbate), electrotherapy, isolated lumbar muscle exercises, home cervical traction, or training in virtual reality showed no benefit. The studies had a high risk of bias, were typically underpowered, and demonstrated high clinical heterogeneity.
CONCLUSIONS: Currently available randomized clinical trials do not provide sufficient evidence to guide military organizations or health care professionals in making appropriate treatment decisions to manage MSK pain in active serving military personnel. Future research is essential to enable evidence-based recommendations for the effective management of MSK pain conditions in this unique population.
Male breast cancer (MBC) accounts for approximately 1% of all breast cancers and among these infiltrating lobular carcinomas (ILC) represents only 1-2% of all MBC cases. Pleomorphic invasive lobular carcinoma (PILC) is an aggressive variant of ILC with only eight cases reported until now in males. Up to 10% of MBC cases have a germline pathogenic variant in a predisposing gene such as BRCA1 and BRCA2 genes. Mutations in PALB2 (partner and localizer of BRCA2) have been reported in men with breast cancer, with a frequency that ranges from 0.8 to 6.4%, but it has never been reported in male ILC. Here, we report a rare and interesting case of an invasive pleomorphic/solid lobular carcinoma, which carries a pathogenic variant in PALB2 gene, and a family history of breast cancer without other well defined risk factors for developing this type of neoplasia. In addition, we review the current literature.
After the forms are applied to the patients and recorded, it will be determined whether they will be in the study or control group according to the randomization schedule. Patients in the study group will be shown a video with virtual reality glasses during the procedure. Patients will be asked to wear a virtual reality goggle (VR Box Virtual Reality Headset 3D Vr Glasses V2.0 2020 model) that is compatible with a mobile phone (Xiaomi Redmi Note 8 Pro 2019 model) with android operating system and minimizes sound loss in the supine position. With the virtual reality glasses, nature landscapes with relaxing music background will be watched by adjusting the volume at the level desired by the patient. Virtual reality glasses will be applied during the urodynamics procedure. After the device is applied to each patient, it will be disinfected in accordance with the company's recommendation.
A method is provided for processing a neural measurement obtained in the presence of noise, in order to detect whether a locally evoked neural response is present in the neural measurement. A first neural measurement is obtained from a first sense electrode. A second neural measurement is contemporaneously obtained from a second sense electrode spaced apart from the first electrode along a neural pathway of the neural response. A neural response decay is determined, being a measure of the decay in the neural response from the first sense electrode to the second sense electrode. A ratio of the neural response decay to an amplitude normalising term is calculated. From the ratio it is determined whether a locally evoked neural response is present in the neural measurement.
AIMS: Right bundle branch block (RBBB) morphology non-sustained ventricular arrhythmias (VAs) have been associated with the presence of non-ischaemic left ventricular scar (NLVS) in athletes. The aim of this cross-sectional study was to identify clinical and electrocardiogram (ECG) predictors of the presence of NLVS in athletes with RBBB VAs.
METHODS AND RESULTS: Sixty-four athletes [median age 39 (24-53) years, 79% males] with non-sustained RBBB VAs underwent cardiac magnetic resonance (CMR) with late gadolinium enhancement in order to exclude the presence of a concealed structural heart disease. Thirty-six athletes (56%) showed NLVS at CMR and were assigned to the NLVS positive group, whereas 28 athletes (44%) to the NLVS negative group. Family history of cardiomyopathy and seven different ECG variables were statistically more prevalent in the NLVS positive group. At univariate analysis, seven ECG variables (low QRS voltages in limb leads, negative T waves in inferior leads, negative T waves in limb leads I-aVL, negative T waves in precordial leads V4-V6, presence of left posterior fascicular block, presence of pathologic Q waves, and poor R-wave progression in right precordial leads) proved to be statistically associated with the finding of NLVS; these were grouped together in a score. A score ≥2 was proved to be the optimal cut-off point, identifying NLVS athletes in 92% of cases and showing the best accuracy (86% sensitivity and 100% specificity, respectively). However, a cut-off ≥1 correctly identified all patients with NLVS (absence of false negatives).
CONCLUSION: In athletes with RBBB morphology non-sustained VAs, specific ECG abnormalities at 12-lead ECG can help in detecting subjects with NLVS at CMR.
BACKGROUND: Dental Patient Reported Outcomes (PROs) relate to a dental patient's subjective experience of their oral health. How practitioners and patients value PROs influences their successful use in practice.
METHODS: Semi-structured interviews were conducted with 22 practitioners and 32 patients who provided feedback on using a mobile health (mHealth) platform to collect the pain experience after dental procedures. A themes analysis was conducted to identify implementation barriers and facilitators.
RESULTS: Five themes were uncovered: (1) Sense of Better Care. (2) Tailored Follow-up based on the dental procedure and patient's pain experience. (3) Effective Messaging and Alerts. (4) Usable Digital Platform. (5) Routine mHealth Integration.
CONCLUSION: Frequent automated and preferably tailored follow-up messages using an mHealth platform provided a positive care experience for patients, while providers felt it saved them time and effort. Patients thought that the mHealth questionnaires were well-developed and of appropriate length. The mHealth platform itself was perceived as user-friendly by users, and most would like to continue using it.
PRACTICAL IMPLICATIONS: Patients are prepared to use mobile phones to report their pain experience after dental procedures. Practitioners will be able to close the post-operative communication gap with their patients, with little interruption of their workflow.
Women randomized to the standard-of-care arm will undergo VIA followed by Visual Inspection with Lugol's Iodine (VILI). Women randomized to the Pocket Colposcope arm will undergo Pocket-Assisted VIA (PA-VIA), green light imaging, and VILI using the Pocket Colposcope. Women in both arms will have biopsies taken of any suspicious lesions, or two biopsies taken in random locations if no lesions are visible. The locations of the biopsies will be based on provider impression. After their study-exams and biopsies are taken, women who are eligible for ablative treatment will be immediately treated in the clinic. Those with larger lesions or lesions concerning for invasive cancer will be referred to the local hospital for an excisional procedure.
The present invention discloses a traditional Chinese medicine preparation for treating sore diseases. The traditional Chinese medicine preparation is prepared by scientifically processing pilose asiabell root, angelica, hemlock parsley, notoginseng, safflower, olibanum, myrrh, dragon blood, lead monoxide, pearl, musk, borneol, etc. The materials are made to a Chinese medicine preparation through scientific processing. The stasis toxin of sore diseases caused by various reasons and inflammations can be drawn from skin deep parts to shallow parts and from the shallow parts to the outside of bodies. Finally, the stasis toxins are eliminated, and the diseases do not relapse after being cured. The immune function of human bodies is largely improved, and no scar exists after cure. In particular, the preparation has significant therapeutic effect and high curative rate in the condition that all kinds of antibiotic do not have effect on the treatment of skin local infection.
Treatment consists of appropriate supportive measures. The patient must be protected against self-injury and against external stimuli that would aggravate overstimulation already present. Gastric contents may be evacuated by gastric lavage as indicated. Before performing gastric lavage, control agitation and seizures if present and protect the airway. Other measures to detoxify the gut include administration of activated charcoal and a cathartic. Intensive care must be provided to maintain adequate circulation and respiratory exchange; external cooling procedures may be required for pyrexia.

Efficacy of peritoneal dialysis or extracorporeal hemodialysis for CONCERTA® overdosage has not been established.

The prolonged release of methylphenidate from CONCERTA® should be considered when treating patients with overdose.
Urinary extracellular vesicles (uEVs) play important roles in physiologic condition and various renal/urological disorders. However, their roles in kidney stone disease remain unclear. This study aimed to examine modulatory effects of large and small uEVs derived from normal human urine on calcium oxalate (CaOx) crystals (the main component in kidney stones). After isolation, large uEVs, small uEVs and total urinary proteins (TUPs) with equal (protein equivalent) concentration were added into various crystal assays to compare with the control (without uEVs or TUPs). TUPs strongly inhibited CaOx crystallization, growth, aggregation and crystal-cell adhesion. Large uEVs had lesser degree of inhibition against crystallization, growth and crystal-cell adhesion, and comparable degree of aggregation inhibition compared with TUPs. Small uEVs had comparable inhibitory effects as of TUPs for all these crystal assays. However, TUPs and large uEVs slightly promoted CaOx invasion through extracellular matrix, whereas small uEVs did not affect this. Matching of the proteins reported in six uEVs datasets with those in the kidney stone modulator (StoneMod) database revealed that uEVs contained 18 known CaOx stone modulators (mainly inhibitors). These findings suggest that uEVs derived from normal human urine serve as CaOx stone inhibitors to prevent healthy individuals from kidney stone formation.
SSRI acts by blocking the serotonin transporter (5-HT), increasing the availability of serotonin at the synaptic cleft averting its reuptake. The increment of serotonin activates 5-HT1A presynaptic autoreceptors, resulting in a modulation in the release of serotonin by the presynaptic neuron. It is proposed that 5-HT1A receptor antagonism could accelerate the clinical effect of antidepressants by preventing this negative feedback.Preclinical data obtained with selective 5-HT1A antagonists, such as pindolol, and with mice lacking 5-HT1a receptors supports this hypothesis. Results on partial antagonists (pindolol) are conclusive in accelerating SSRI. It is reasonable to call into question whether a total antagonism of 5-HT1a receptors could imply a more rapid antidepressant response. To test this hypothesis we conducted a double blind, randomised, controlled trial with DU 123550 added to fluoxetine 20 mg/day
Abstract A system and method for utilizing a portable phototherapy device for the treatment of psoriasis. A portable narrow-band ultraviolet-B (UVB) device is used to detect and treat different skin diseases such as psoriasis.  This device has the combination of both hardware and software. It includes a sharp distance sensor, a camera for image processing, a Bluetootht module for wireless connectivity and an IoT program. The camera takes pictures of a person's skin, then the severity of the disease is determined through it. This device includes artificial intelligence to diagnose psoriasis and intelligent control for dosage rate. This device also has image processing to show the improvement of the skin. It should be noted that ultraviolet B (UVB) radiation increases cutaneous vitamin D synthesis. Therefore, treatment with the above device leads to an increase in vitamin D absorption which can help boost the immune system to fight other diseases and viruses. Date Recue/Date Received 2022-05-20 A system and method for utilizing a portable phototherapy device for the treatment of psoriasis. A portable narrow-band ultraviolet-B (UVB) device is used to detect and treat different skin diseases such as psoriasis.  This device has the combination of both hardware and software. It includes a sharp distance sensor, a camera for image processing, a Bluetooth  module for wireless connectivity and an IoT program. The camera takes pictures of a person's skin, then the severity of the disease is determined through it. This device includes artificial intelligence to diagnose psoriasis and intelligent control for dosage rate. This device also has image processing to show the improvement of the skin. It should be noted that ultraviolet B (UVB) radiation increases cutaneous vitamin D synthesis. Therefore, treatment with the above device leads to an increase in vitamin D absorption which can help boost the immune system to fight other diseases and viruses.
Pressure ulcers (PUs) are a common complication in postoperative patients with traumatic brain injury, and this study used a meta-analysis to assess the effects of comprehensive nursing applied in PUs intervention in postoperative patients with traumatic brain injury. A computerised systematic search of the PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, Chinese Biomedical Literature Database (CBM), VIP and Wanfang databases was performed to collect publicly available articles on randomised controlled trials (RCTs) on the effects of comprehensive nursing interventions in postoperative patients with traumatic brain injury published up to August 2023. Two researchers independently completed the search and screening of the literature, extraction of data and quality assessment of the included literature based on the inclusion and exclusion criteria. Meta-analysis was performed using RevMan 5.4 software. Twenty-eight articles were finally included, for a cumulative count of 2641 patients, of which 1324 were in the intervention group and 1317 in the control group. The results of the meta-analysis showed that, compared with conventional nursing, comprehensive nursing intervention helped to reduce the incidence of PUs in postoperative patients with traumatic brain injury (5.14% vs. 19.67%, odds ratio [OR]: 0.22, 95% confidence interval [CI]: 0.16-0.29, p < 0.00001) and reduced the incidence of postoperative complications (7.87% vs. 25.84%, OR: 0.22, 95% CI: 0.11-0.43, p < 0.0001), while increasing patient satisfaction (96.67% vs. 75.33%, OR: 9.5, 95% CI: 3.63-24.88, p < 0.00001). This study concludes that a comprehensive nursing intervention applied to postoperative patients with traumatic brain injury can significantly reduce the incidence of PUs and postoperative complications as well as improve nursing satisfaction, and it is recommended for clinical promotion. However, due to the limitations of the studies' number and quality, more high-quality, large-sample RCTs are needed to further validate the conclusions of this study.
<P>PROBLEM TO BE SOLVED: To provide an intraluminal device, in particular an intraluminal prosthesis, shunt, catheter or local drug delivery device.  <P>SOLUTION: In order to increase the bio-compatibility of this device, it is provided with at least one coating. The coating contains a therapeutic agent which is comprised in a matrix that sticks to the intraluminal device. Instead of being formed by a little bio-compatible polymer, the matrix is formed by a bio-compatible oil or fat, such as cod-liver oil or olive oil. Preferably, the bio-compatible oil or fat further comprises alfa-tocopherol.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
PCT No. PCT/US97/18950 Sec. 371 Date Oct. 18, 1999 Sec. 102(e) Date Oct. 18, 1999 PCT Filed Oct. 17, 1997 PCT Pub. No. WO98/17809 PCT Pub. Date Apr. 30, 1998The present invention relates to recombinant hemoglobin solutions containing reduced amounts of protoporphyrin IX and to methods of producing such hemoglobin solutions. The methods are accomplished by overexpressing the hemH gene in a suitable host cell or by increasing the production of hemH in a host cell, for example, by integration of the hemH gene into the chromosome of the host cell or by inserting multiple copies of the gene in host cells naturally having a hemH gene.
<P>PROBLEM TO BE SOLVED: To provide a cosmetic preparation giving a good impression at use and its manufacturing method.  <P>SOLUTION: The cosmetic preparation contains an extract from a plant belonging to Saussurea spp., especially an extract from at least one plant chosen from the group consisting of Saussurea involucrate (Kar. et Kir.) Sch. Blp., Saussurea medusa Maxim. and Saussurea laniceps Hand. -Mazz. and mineral-containing water, especially water obtained by passing purified water through an active water tank filled with minerals or water containing at least 20 ppb sodium, 5 ppb potassium, 10 ppb calcium and 1 ppb magnesium as mineral components. In the manufacturing method of the cosmetic preparation, the mineral-containing water is prepared by passing the purified water through the active water tank filled with various minerals.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
FIELD: medicine. SUBSTANCE: this magnetically controlled carrier of medicinal substances is characterized in that its sorbing part is made in the form of separate sorbent particles and magnetic part is made in the form of porous film covering these particles and permeable to molecules of medicinal substances. Method for manufacture of magnetically controlled carrier of medicinal substances is characterized in that sorbing portion of preset size is either suspended or manufactured by comminuting sorbent to desired particle size and magnetic film is applied to surface of sorbent particle. Charcoal may be used as sorbent. Magnetic film may be made of magnetic alloy based on iron, cobalt and other microelements and including platinum. Magnetic film is applied to surface of sorbent particle by method of electrolytic deposition in amount of 20 to 80 % by mass of single particle. EFFECT: excellent results.
The investigators will determine the extent to which home-based leg heat therapy improves functional capacity in older adults. Functional capacity will be assessed before and after heat therapy or sham intervention via the 6-min walk test and the Short Physical Performance Battery.
Animal feeds comprising a compound that disrupts the peptidoglycan layer of bacteria and a compound that disrupts the phospholipid layer of bacteria are disclosed. The feed is particuarly active against Gram negative bacteria which possess both a lipopolysaccharide/lipid outer layer, and an inner peptidoglycan layer. The compounds can act synergistically against bacteria, and therefore improve the growth or the feed conversion ratio of animals. The feed may be fed to monogastric and/or non-ruminant animals such as poultry, pigs, piglets, (veal) calves or fish. The phospholipid disrupting compound can be a phospholipase, polyunsaturated fatty acid (PUFA, such as arachidonic acid) or a chelating agent (such as EDTA). The peptidoglycan disrupting layer can be an enzyme, such as an endoglycosidase or a peptidase, that can either hydrolyse peptidoglycan or cleave peptide crosslinks. The enzyme is preferably lysozyme.
FIELD: organic chemistry, cosmetics, detergents. SUBSTANCE: invention relates to composition for washing keratin materials containing in cosmetically acceptable medium at least one anionic surface-active washing agent, at least one oxyethyleneted sorbitan ester with saturated or unsaturated, linear or branched aliphatic C 8 -C 30 -acid where number of ethylene oxide mole is below or equal to 10. Weight ratio of anionic washing surface- -active agent to sorbitan ester with aliphatic C 8 -C 30 -acid is from 0.5 to 5. Invention relates also to the usage of the above-mentioned sorbitan ester with aim to attenuate irritating effect of eye and improve thickening property of composition for washing keratin materials and to method of washing keratin materials. Composition shows soft effect on eyes and improved thickening property. EFFECT: improved and valuable properties of composition. 17 cl, 1 dwg
Actin-free myosin is separated from intimate association with polymerized actin in muscle material, e.g. raw muscle, actomyosin which may be prepared according to Specification 745,715, "myosin B", by heating the material, which has been substantially freed from adenosine triphosphate, with an aqueous salt solution which comprises an alkali metal iodide or thiocyanate, e.g. sodium or potassium salt, at a temperature below 10 DEG  C., and diluting the extract with water to a salt concentration of below 0.05 M to precipitate the myosin.  If the starting material contains adenosine triphosphate, e.g. fresh raw muscle, it is washed with a solvent, e.g. water, dilute aqueous potassium chloride, or potassium chloride and phosphate solutions, to remove substantially all the adenosine triphosphate e.g. to a concentration of less than 10-5 M, prior to the extraction of the actin and myosin with a solution of the salt of concentration between 0.4 and 0.8 M.