anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Probiotics hold great potential for treating metabolic diseases such as obesity. Given the complex and multifactorial nature of these diseases, research on probiotic combination with multiple targets has become popular. Here, we choose four obesity-related targets to perform high-throughput screening, including pancreatic lipase activity, bile salt hydrolase activity, glucagon-like peptide-1 secretion and adipocyte differentiation. Then, we obtained 649 multi-strain combinations with the requirement that each must cover all these targets in principle. After in vitro co-culture and in vivo co-colonization experiments, only four (<0.7%) combinations were selected as symbiotic probiotic communities (SPCs). Next, genome-scale metabolic model analysis revealed that these SPCs showed lower metabolic resource overlap and higher metabolic interaction potential involving amino acid metabolism (Ammonium, L-Lysine, etc.) and energy metabolism (Phosphate, etc.). Further animal experiments demonstrated that all SPCs exhibited a good safety profile and excellent effects in improving obesity and associated glucose metabolism disruptions and depression-like behaviors in high-fat-diet-fed mice. This anti-obesity improvement was achieved through reduced cholesterol level, fat accumulation and inhibited adipocyte differentiation. Taken together, our study provides a new perspective for designing multi-strain combinations, which may facilitate greater therapeutic effect on obesity and other complex diseases in the future.
The health education comparison intervention consisted of once weekly, 90-minute health information workshops conducted in group format. Sessions generally consisted of a 60-minute lecture followed by 30 minutes of questions and discussion.
Since mid February 2003, there have been reports of atypical pneumonias originating in China which have subsequently been termed the Severe Acute Respiratory Syndrome (SARS). SARS has subsequently spread to multiple countries including the United States, and is accompanied by a higher than anticipated morbidity and mortality. Because of world travel and the apparent easy transmissibility of this disease reported in other nations, the number of patients with SARS may continue to rise. The primary purpose of this protocol is to evaluate and treat persons with SARS. Other goals will be to characterize the clinical course of SARS by also evaluating close contacts of people with SARS, as well as those that have recovered from SARS. Additional goals of the protocol are to elucidate the pathophysiology of SARS, characterize the immune response during SARS, and evaluate diagnostic tests for the rapid identification of SARS in clinical specimens. Further knowledge about SARS may lead to effective forms of therapy and improve mortality from this disease.
A 42-year-old female patient was admitted to hospital due to acute neurological symptoms (dysarthria, disorientation). After exclusion of cerebral ischemia and hemorrhage an autoimmune encephalitis was diagnosed. Shortly before as an outpatient the suspicion of the presence of systemic lupus erythematosus (SLE) was voiced. The patient showed a constellation of high levels of inflammatory laboratory parameters and within a few days developed a severe pancytopenia. In the presence of all diagnostic criteria a secondary hemophagocytic lymphohistiocytosis (sHLH) was diagnosed and confirmed by a kidney biopsy during the course of the underlying SLE. The immunosuppressive treatment with etoposide and high-dose dexamethasone according to the HLH-94 protocol only showed temporary success. After 3 weeks of treatment with a protocol-conform dose reduction, under running treatment a new exacerbation of symptoms was confirmed. A renewed dose escalation of the drugs used did not lead to control of the symptoms. The inflammatory activity could only be sustainably controlled by the use of cyclosporin A in combination with mycophenolate mofetil (MMF) and dexamethasone. After stabilization of the condition of the patient, an outpatient follow-up care was possible.
A confirmatory factor analysis (CFA) of the Tinnitus Impact Questionnaire (TIQ) was performed. In contrast to commonly used tinnitus questionnaires, the TIQ is intended solely to assess the impact of tinnitus by not including items related to hearing loss or tinnitus loudness. This was a psychometric study based on a retrospective cross-sectional analysis of clinical data. Data were available for 155 new patients who had attended a tinnitus and hyperacusis clinic in the UK within a five-month period and had completed the TIQ. The mean age was 54 years (standard deviation = 14 years). The TIQ demonstrated good internal consistency, with Cronbach's α = 0.84 and McDonald's ω = 0.89. CFA showed that two items of the TIQ had low factor loadings for both one-factor and two-factor models and their scores showed low correlations with scores for other items. Bi-factor analysis gave a better fit, indicated by a relative chi-square (χ2) of 18.5, a Root-Mean Square Error of Approximation (RMSEA) of 0.103, a Comparative Fit Index (CFI) of 0.97, a Tucker Lewis Index (TLI) of 0.92, and a Standardized Root-Mean Residual (SPMR) of 0.038. Total TIQ scores were moderately correlated with scores for the Visual Analogue Scale of effect of tinnitus on life and the Screening for Anxiety and Depression-Tinnitus questionnaire, supporting the convergent validity of the TIQ. The TIQ score was not correlated with the pure-tone average hearing threshold, indicating discriminant validity. A multiple-causes multiple-indicator (MIMIC) model showed no influences of age, gender or hearing status on TIQ item scores. The TIQ is an internally consistent tool. CFA suggests a bi-factor model with sufficient unidimensionality to support the use of the overall TIQ score for assessing the impact of tinnitus. TIQ scores are distinct from the impact of hearing impairment among patients who have tinnitus combined with hearing loss.
One hundred seventy two (N=172) patients with sciatica for at least six weeks with radicular pain below the knee will be involved this study. The patients with non-urgent referrals due to sciatica symptoms will be directed to specialized medical care hospitals (the district central hospitals of Central Finland and South Ostrobothnia and the University hospital of Kuopio, Finland) to the physiatrists and orthopedic outpatient clinics for further investigations for possible surgery. The patient will be seen for a doctor's examination within a week. If the clinical examination reveals that a patient needs spinal disc herniation surgery, and the patient is willing to undergo surgery, they will be referred for X-ray imaging if it has not already been done in basic health care, in accordance with the regular treatment procedure, and to an MRI scan.

While patients are waiting for their MRI scan, they will undergo a clinical McKenzie-based mechanical assessment and be put into sub-groups of "centralizers"or "non-centralizers". These will be randomly assigned into a McKenzie group and into an advice to stay active group. Based on their MRI findings and clinical signs and symptoms they will be assigned to surgery or continue their non-surgical treatments. If the MRI scan does not reveal a spinal disc herniation finding that fulfills the criteria of the study, the patient is removed from the study in accordance with the selection criteria, regardless of whether they belong to the MDT or advice to stay active group, and their treatment will continue according to the hospital's normal procedures.
ETHNOPHARMACOLOGICAL RELEVANCE: According to traditional Chinese medicine (TCM) theory, post-traumatic stress disorder (PTSD) is a kind of depression syndrome, and its occurrence is related to deficiencies of the heart and kidney. Polygonatum cyrtonema Hua replenishes Qi and blood and tonifies the five zang organs, so it is widely used in TCM as a prescription for the treatment of depression syndrome. The polysaccharides in P. cyrtonema Hua (PSP) are the main active components of the herb, but the effects of PSP on PTSD and the mechanisms remain unclear.
AIM OF THE STUDY: To investigate the preventive effect of PSP on PTSD-like behaviors and to determine the mechanisms.
METHODS: We used behavioral tests to evaluate PTSD-like behaviors in mice. Synaptic changes were assessed by transmission electron microscopy. Hematoxylin-eosin staining was used to assess pathological changes to the hippocampus, and immunofluorescence staining was used to observe changes in astrocytes. Serum corticosterone (CORT), cytokine, and hippocampal oxidation-related indicator levels were evaluated by ELISA. We detected the expression levels of synaptic, oxidative, and inflammation-related proteins in the hippocampus by western blotting.
RESULTS: Single prolonged stress (SPS)-modeled mice exhibited significant PTSD-like phenotypes, including increased fear memory acquisition and anxiety-like behaviors. These behavioral changes were prevented by PSP administration. Compared to controls, SPS modeling increased serum CORT, cytokine, and hippocampal malondialdehyde levels; decreased superoxide dismutase activity; and caused losses in pyramidal neurons, astrocytes, and synapses in the CA1 region. At the molecular level, the expression of brain-derived neurotrophic factor, postsynaptic density protein 95, nuclear factor erythroid 2-related factor 2 (Nrf2), phospho-tyrosine kinase receptor B, activity-regulated cytoskeleton-associated protein, heme oxygenase-1 (HO-1), and GluA1 decreased in SPS mice compared with the control group, while the expression of NOD-like receptor protein 3 (NLRP3), GluN2B, and apoptosis-associated speck-like protein increased in SPS mice. Treatment with PSP counteracted these abnormal changes. Importantly, ML385, an Nrf2 inhibitor, blocked PSP's ability to ameliorate PTSD behaviors and abnormal protein expression. The NLRP3 inhibitor MCC950 reduced the PTSD-like behaviors and normalized protein expression in SPS mice.
CONCLUSION: PSP prevents SPS-induced PTSD-like behaviors and synaptic damage by regulating oxidative stress and NLRP3-mediated inflammation, probably in an Nrf2/HO-1 signaling pathway-dependent manner.
All participants will be asked to consume 32 ounces daily of Green Tea. The beverage will be previously prepared and packaged by study personnel. Participants will receive their beverage supply on a weekly basis for a total of six weeks.
Patients will receive methylprednisolone at a dose of 1.5 mg / kg / day divided into 2 daily doses for 7 days. Then they will receive 1 mg / kg / day for another 7 days in two daily doses. Finally 0.5 mg / kg / day for another 7 days.
Volatile organic pollutants (VOCs) are taken as a common pollutant in an industrial field, the main exposure way is that the VOCs enter a human body through respiration, accurate control of the exposure way and quantitative analysis are difficult to carry out, and the VOCs are always the key and difficult points in field development work. At present, the national assessment site Volatile Organic Compounds (VOCs) health risk mostly uses American Society for Testing Materials (ASTM) recommendation models, such as Johnson-Ettinger (abbreviated as J & E) models. In practical application, migration of VOCs in soil environment is also found to be influenced by various environmental factors, the situation is not ideal in accordance with theory, and multiple studies prove that risk assessment based on soil concentration may overestimate actual level. Therefore, more and more attention is paid to the risk evaluation based on the measured soil gas VOCs concentration. Compared with soil and underground water sampling, the soil gas sampling development time is shorter, and the internationally existing soil gas sampling can be divided into active sampling and passive sampling. Compared with the traditional VOCs passive sampling, the combination of the passive sampler and the flux box can effectively reduce the interference of moisture on the adsorbent, the detection of VOCs volatilization flux can not be limited by the adsorption rate of the passive sampler, and better play a role in risk assessment. The combination of passive samplers and flux boxes enables the passive sampling technique to be more widely used.
The incidence and prevalence of cardiac and cerebrovascular diseases are constantly increasing, with chronic coronary syndrome and ischemic stroke as the leading causes of morbidity and mortality worldwide. According to current knowledge, the heart-brain axis is more than a theoretical concept, with many common pathophysiological mechanisms involved in the onset and evolution of both coronary and cerebral ischemia. Moreover, the focus is on the prevention and early intervention of risk factors in searching for targeted and personalized medical treatment. In this context, this narrative review aims to offer, in a didactic and practice-oriented manner, an up-to-date overview of the role played by lipid-derived biomarkers (from low-density lipoprotein cholesterol to oxylipin and apolipoproteins) in chronic coronary syndrome and ischemic stroke. Firstly, the authors highlight, via relevant epidemiological data, the significant burden of chronic coronary syndrome and ischemic stroke in the general population, thus explaining the need for updated information on this topic. Subsequently, the most important lipid-derived biomarkers and their multiple roles in the pathogenesis of these two disorders are listed. Currently available and experimental targeted therapies based on these lipid-derived biomarkers are presented in the final part of this paper, representing this manuscript's original and novel input.
OBJECTIVES: To observe the effect of catgut embedding at "Feishu"(BL13), "Dingchuan" (EX-B1) and "Danzhong" (CV17) on expression of phosphorylated p38 mitogen activated protein kinase (p-p38 MAPK), interleukin-4 (IL-4), interferon-γ (IFN-γ) and changes of airway epithelial cells (AEC) in the lung tissue of bronchial asthma (BA) rats, so as to explore its mechanisms underlying improvement of BA.
METHODS: Forty male Wistar rats were randomly and equally divided into blank control, model, dexamethasone (DEX) and catgut embedding groups. The BA model was established by intraperitoneal injection of suspension of ovalbumin and aluminum hydroxide. Rats of the DEX group received intraperitoneal injection of DEX (1.5 mg/kg), once daily for 2 weeks, and those of the catgut embedding group received catgut embedding at BL13, EX-B1 and CV17 only one time. The rats' sneezing times per miniute in each group were recorded. H.E. staining was used to observe the histopathological changes of the lung tissue under light microscope. A transmission electron microscope (TEM) was used to observe the ultrastructural changes of AEC in the lung tissue, including the thickness of bronchial wall and bronchial smooth muscle by using an image analysis software. The protein expressions of p-p38 MAPK, IL-4 and INF-γ in the lung tissue were determined using Western blot.
RESULTS: Morphological observation revealed that in the model group, light microscope showed deformed and swollen bronchial tube wall with increased folds and thickened bronchial smooth muscle;and TEM showed a large number of autophagy vesicles containing swollen and deformed organelles in the AEC, and apparent reduction of intracellular mitochondria, these situations were obviously milder in both DEX and catgut embedding groups. Compared with the blank control group, the sneezing times, thickness of bronchial wall and bronchial smooth muscle in the model group were significantly increased (P<0.01), and the expressions of p-p38 MAPK and IL-4 in lung tissue were significantly increased (P<0.01), while the expression of IFN-γ was significantly decreased (P<0.01) in the model group. In comparison with the model group, the sneezing times, thickness of bronchial wall and bronchial smooth muscle, protein expressions of p-p38 MAPK and IL-4 were significantly decreased (P<0.01), while the expression of IFN-γ was obviously increased (P<0.01) in both the DEX and catgut embedding groups.
CONCLUSIONS: Acupoint catgut embedding can reduce the expression of IL-4 and increase the expression of IFN-γ by inhibiting p38 MAPK signal pathway of lung tissues in BA rats, which may contribute to its effect in alleviating the degree of airway epithelial cells damage.
This is a pre-post survey study of Communitas, a pre-existing integrative medicine and mind-body skills group visit for adolescents living with chronic illness and their parents. Approximately 50-100 patient enrollees of the Communitas group visits will be recruited to participate in this survey study optionally.
PURPOSE: A novel synthetic peptide in which gene transfer efficiency is improved and a gene transfer method using the same are provided to enhance gene delivery ability to cells or inside the organs, thereby being used for a gene transfer. CONSTITUTION: A novel synthetic peptide in which gene transfer efficiency is improved includes comprises the amino acid sequence of the sequence number 1(SEQ ID NO:1) or 2 originated from Tat or NLS (nuclear localization sequence) of HIV(human immunodeficiency virus). The gene transmission peptide is represented by chemical formula 1 or chemical formula 2 (Ya-Xb-Cys-Cys-Xc-Yd). In the chemical formula 1 and 2, X indicates amino acid sequence of the sequence number 1 and Y indicates the amino acid sequence of the sequence number 2. The gene transfer peptide is expressed as the amino acid sequence selected from the sequence number 3-10. In the gene transfer complex, genes to be transferred to the peptide are combined. The gene is DNA or RNA. The composite additionally includes cation liposome.
Bacterial pneumonia is a main cause for mechanical artificial respiration in an intensive care unit. We assumed that the existence of a specific microorganism group in an aspirate in an organ during an intubation procedure is related with a clinical test result such as an intubation fail or a 28-day death rate. From 60 intensive care unit patients using a mechanical respirator (41 pneumonia patients and 19 non-pneumonia patients), 216 aspirates in their organ were obtained on the first, third and seventh days. 22 patients had successful extubation within three weeks and 12 patients died within 28 days. Microorganism group profiles between a pneumonia group and a non-pneumonia group are significantly different (Adonis, P <0.01). In the successful extubation group, α-diversity (Shannon index) was considerably reduced between the first day and the seventh day, whereas, in the extubation fail group of the pneumonia patients, there was no reduction. There was a significant difference in an α-diversity variation between the successful extubation group and the extubation fail group at Bray-Curtis distance (P<0.001). There was a correlation with the variation of the α-diversity variation at the level of Rothia Streptococcus, and Prevotella. When the intubation was conducted, the relative richness of the Streptococcus was closely related with the 28-day death rate. The epidemiology of the respiratory microorganism group is related with a clinical test result such as an extubation failure and death.
The invention relates to an application of a pharmaceutical composition in preparing a medicament for treating tumors. Specifically, the cGAS inhibitor is selected from compounds shown in a formula (I) or pharmaceutically acceptable salts thereof. The combination of cGAS inhibitors with chemotherapeutic agents such as cisplatin further enhances the anti-tumor effect compared to single agents. Can be used for effectively killing tumor cells such as lung cancer and the like or drug-resistant tumor cells, and remarkably reducing the nephrotoxicity of cisplatin. The invention firstly proves the sensitization effect of the cGAS inhibitor on the antitumor drugs in vivo and in vitro levels, proves the treatment synergy effect of the cGAS inhibitor as a sensitizer on cancers such as lung cancer, breast cancer, colorectal cancer, gastric cancer, liver cancer, glioma and the like, and has the advantage of small side effect. The invention provides a new way and means for effectively treating lung cancer.
Controls will be individuals who have used ESL for at least 6 weeks and who have not developed SCAR. Blood draw or saliva.
The biologically active polybacterial complex for immunoprophylaxis and immunotherapy in mammal animals contains a polybacterial substance of killed bacterial bodies and lysates of: two Escherichia coli strains - Escherichia coli 29 express type 1 and P pili, and Escherichia coli Rc mutant, and one Staphylococcus aureus strain û for the three strains regardless of the depositary number, as well as a stabilizer comprised in the polybacterial substance. Dextran-40 is used as a stabilizer. Each of the two Escherichia coli strains, as part of the polybacterial substance, is in the range of 20 to 40 percent, while the Staphylococcus aureus strain is in the range of 20 to 60 percent. The bacterial substance is in a quantity of 10 x 109 bacterial bodies in mg active substance from each of the three strains and mass with density of 7.5 x 109/ml before the freeze-drying with the use of the stabilizer. The polybacterial substance and the stabilizer are in weight percent as follows: polybacterial substance from 30 to 50, and dextran stabilizer 40 from 50 to 70. The drug form based on the polybacterial complex represents a tablet and contains: polybacterial complex, macrogol 6000 (PEG), crospovidone (colidone), and silicified microcrystalline cellulose (SMCC) in the following weight percent: polybacterial complex from 35 to 41, macrogol 6000 (PEG) from 2.88 to 3.12, crospovidone (colidone) from 10.66 to 11.34, and silicified microcrystalline cellulose (SMCC) from 45.46 to 50.54. The polybacterial complex and the tablet drug form containing it are intended for animals of all age groups, including newborns û either suckers or weaned, as well as pregnant and lactating animals û mothers. They are used for prevention and treatment of acute and chronic infections, particularly in cases of colienteritis and bronchopneumonia, as well as for the full utilization of food and increasing the growth of the animals.