anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A standardized partial pulpotomy procedure will be performed after administration of local anesthesia. The PRF membrane obtained after centrifugation of the patient's own blood is going to be placed over the exposed pulp. Then, a 3mm of MTA (Pro Root MTA) will be placed over the PRF membrane.
Pill pack packaging that monitors and reports on pill compliance is disclosed. The pill pack packaging includes a circuit disposed on the cover of pill receptacles. A processor monitors the changes in electrical signals from the circuit. When the electrical signals change, the processor records the time and date. The processor may also report the time and date of pill receptacle opening to a mobile device via wireless transmission. The device may also be capable of providing alerts regarding lack of compliance or loss of the pill pack.
Muscle wasting is a serious complication in heart failure patients. Oxidative stress and inflammation are implicated in the pathogenesis of muscle wasting. Oxidative stress leads to the formation of toxic lipid peroxidation products, such as 4-hydroxy-2-nonenal (HNE), which covalently bind with proteins and DNA and activate atrophic pathways. Whether the formation of lipid peroxidation products and metabolic pathways that remove these toxic products are affected during heart failure-associated skeletal muscle wasting has never been studied. Male C57BL/6J mice were subjected to sham and transverse aortic constriction (TAC) surgeries for 4, 8 or 14 weeks. Different skeletal muscle beds were weighed, and the total cross-sectional area of the gastrocnemius muscle was measured via immunohistochemistry. Muscle function and muscle stiffness were measured by a grip strength meter and atomic force microscope, respectively. Atrophic and inflammatory marker levels were measured via qRT‒PCR. The levels of acrolein and HNE-protein adducts, aldehyde-removing enzymes, the histidyl dipeptide-synthesizing enzyme carnosine synthase (CARNS), and amino acid transporters in the gastrocnemius muscle were measured via Western blotting and qRT‒PCR. Histidyl dipeptides and histidyl dipeptide aldehyde conjugates in the Gastrocnemius and soleus muscles were analyzed by LC/MS-MS. Body weight, gastrocnemius muscle and soleus muscle weights and the total cross-sectional area of the gastrocnemius muscle were decreased after 14 weeks of TAC. Heart weight, cardiac function, grip strength and muscle stiffness were decreased in the TAC-operated mice. Expression of the atrophic and inflammatory markers Atrogin1 and TNF-α, respectively, was increased ~ 1.5-2fold in the gastrocnemius muscle after 14 weeks of TAC (p < 0.05 and p = 0.004 vs sham). The formation of HNE and acrolein protein adducts was increased, and the expression of the aldehyde-removing enzyme aldehyde dehydrogenase (ALDH2) was decreased in the gastrocnemius muscle of TAC mice. Carnosine (sham: 5.76 ± 1.3 vs TAC: 4.72 ± 0.7 nmol/mg tissue, p = 0.04) and total histidyl dipeptide levels (carnosine and anserine; sham: 11.97 ± 1.5 vs TAC: 10.13 ± 1.4 nmol/mg tissue, p < 0.05) were decreased in the gastrocnemius muscle of TAC mice. Depletion of histidyl dipeptides diminished the aldehyde removal capacity of the atrophic gastrocnemius muscle. Furthermore, CARNS and TAUT protein expression were decreased in the atrophic gastrocnemius muscle. Our data reveals that reduced expression of ALDH2 and depletion of histidyl dipeptides in the gastrocnemius muscle during heart failure leads to the accumulation of toxic aldehydes and might contribute to muscle wasting.
<P>PROBLEM TO BE SOLVED: To provide a skin care preparation free from the problems of stability and safety and having excellent effect for preventing or ameliorating chapped skin and aging of the skin.  <P>SOLUTION: The skin care preparation contains a hydrolyzed silk protein and an antiinflammatory agent. The hydrolyzed silk protein is preferably hydrolyzed sericin. The hydrolyzed silk protein preferably has an average molecular weight of 10,000-20,000 and especially preferably contains 20-40 mol% sericin as an amino acid composition. The amount of the hydrolyzed silk protein in the total skin care preparation is preferably 0.0001-20 wt.% and the amount of the antiinflammatory agent in the total skin care preparation is preferably 0.0001-5 wt.%.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
PROBLEM TO BE SOLVED: To obtain a film which enables the percutaneous absorption of a clinically effective amt. of a poultice when used for supporting it while hardly causing contact dermatitis by selecting a polyester film having a specified thickness and a specified vol. void content. SOLUTION: This polyester (e.g. polyethylene terephthalate) film selected has a thickness of 0.5-5μm, pref. 0.8-4μm, still pref. 1.0-3.54μm, and such characteristics that the vol. void content is 0.3-1.5%, pref. 0.5-1.2%, that pref. the refractive indexes in the longitudinal and transverse directions are each 1.640-1.675, and that the birefringence is pref. 0.03 or lower. The film is obtd. e.g. by conducting a polyester-forming reaction in the presence of an inert fine powder (e.g. CaCO3 ), melt forming the resultant polyester into a film, biaxially orienting the film, and thermally treating it.
Tissue engineering structures with biologically favorable structural and chemical properties are disclosed. More particularly, the present disclosure is directed to tissue engineered scaffolds having a fiber support and honey. The tissue engineered scaffolds having a fiber support and honey can further include at least one biomolecule. The tissue engineered scaffolds can be used to promote cellular chemotaxis, enhance cell proliferation, enhance extracellular matrix production, increase angiogenesis, and provide antimicrobial activity. The nature of the tissue engineered scaffolds provides a template for cellular infiltration and guide tissue regeneration. The tissue engineered scaffolds can be used in the treatment of dermal wounds (burns, chronic wounds, etc.) or as a tissue engineering scaffold in a wide range of applications.
Recent advancements in understanding the tumor microenvironment (TME) have highlighted the critical role of the nervous system in cancer progression. This review comprehensively examines how the nervous system influences various aspects of tumorigenesis, including growth, motility, immune response, angiogenesis, and the behavior of cancer-associated fibroblasts (CAFs). We delineate the neurodevelopmental mechanisms associated with cancer, such as the secretion of neurotrophins and exosomes by cancer cells. Furthermore, we explore the emerging therapeutic strategy of targeting nerves associated with tumors. Evidence supporting this approach includes studies demonstrating direct tumor growth inhibition, enhanced efficacy of immunotherapy when combined with nervous system-modulating drugs, and the suppression of tumor blood vessel formation through nerve targeting. Finally, we discuss the current challenges in this field and emphasize the need for further exploration within cancer neuroscience.
Hepatitis C virus (HCV) infection alters lysophosphatidylcholine (LPC) metabolism, enhancing viral infectivity and replication. Direct-acting antivirals (DAAs) effectively treat HCV and rapidly normalize serum cholesterol. In serum, LPC species are primarily albumin-bound but are also present in lipoprotein particles. This study aims to assess the impact of HCV eradication on serum LPC species levels in patients infected with HCV. Therefore, 12 different LPC species were measured by electrospray ionization tandem mass spectrometry (ESI-MS/MS) in the sera of 178 patients with chronic HCV infections at baseline, and in 176 of these patients after therapy with DAAs. All LPC species increased at 4 and 12 weeks post-initiation of DAA therapy. The serum profiles of the LPC species were similar before and after the viral cure. Patients with HCV and liver cirrhosis exhibited lower serum levels of all LPC species, except LPC 16:1, both before and after DAA treatment. Percentages of LPC 18:1 (relative to the total LPC level) were higher, and % LPC 22:5 and 22:6 were lower in cirrhotic compared to non-cirrhotic patients at baseline and at the end of therapy. LPC species levels inversely correlated with the model of end-stage liver disease score and directly with baseline and post-therapy albumin levels. Receiver operating characteristic curve analysis indicated an area under the curve of 0.773 and 0.720 for % LPC 18:1 (relative to total LPC levels) for classifying fibrosis at baseline and post-therapy, respectively. In summary, HCV elimination was found to increase all LPC species and elevated LPC 18:1 relative to total LPC levels may have pathological significance in HCV-related liver cirrhosis.
In locally advanced nasopharyngeal carcinoma(NPC), although fist-line therapy with radiotherapy and chemotherapy (Cisplatin/Docetaxel/5-Fu) and second-line therapy with chemotherapy has been given, patients still locally recurrence and distant metastasis. There is no standard treatment recommendation for locally recurrent or metastatic NPC who failed to second-line therapy. Apatinib has been approved as a second-line treatment for advanced gastric cancer. Several phase III studies of liver cancer, non small cell lung cancer and other tumors also showed apatinib has less toxicities and better tolerance. However, the clinical application of apatinib in nasopharyngeal carcinoma is still lack of evidence-based medicine. And this trial is designed to investigate the efficacy and safety of apatinib in locally recurrent or metastatic NPC.
BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common monogenic form of stroke and is characterised by early onset stroke and dementia. Most strokes are lacunar ischaemic strokes, but intracerebral haemorrhage (ICH) has also been reported, although there are limited published data on its frequency and characteristics.
METHODS: A retrospective review of a prospectively recruited CADASIL register from the British National Referral clinic was performed to identify acute ICH cases and their characteristics. In addition, a systematic review of ICH in CADASIL was performed. MEDLINE (Pubmed), Embase, and Web of Science were searched for articles published from inception until 31/05/2023.
RESULTS: Ten cases of ICH were identified from the National clinic register of 516 symptomatic patients, giving an estimated point prevalence of 1.9%. An additional 119 cases were identified from the systematic review, comprising 129 cases and 142 ICH events in total. Including all identified cases, the mean age at onset of ICH was 56.6 ± 15.7 (SD) years, and 74 (57.4%) were male. ICH was the first manifestation of the disease in 32 patients (38.1%), and ICH recurrence occurred in 16 (12.4%). Most ICHs were subcortical, with the thalamus, 58 (40.8%), and basal ganglia, 34 (23.9%), being the commonest sites. Anticoagulation, but not antiplatelet agents, was associated with an increased risk of ICH (20.0% vs. 1.9%, p = 0.006).
CONCLUSIONS: ICH is a relatively rare manifestation of CADASIL, occurring in about 2% of symptomatic cases. Most of the haemorrhages occurred in the subcortical regions.
OBJECTIVES: The herbs in Tao Hong Si Wu Decoction (THSWD) are beneficial in the treatment of cognitive impairment. However, the underlying mechanisms of THSWD in treating diabetes-associated cognitive dysfunction (DACD) are not entirely explored. This study is aimed to investigate the therapeutic effects of THSWD in DACD model rats and the underlying mechanism.
METHODS: Ultra-high-phase liquid chromatography was employed to identify the main compounds contained in the THSWD extract. DACD rat model was induced by feeding with a high-sugar and high-fat diet and injecting streptozotocin (35 mg/kg). DACD rats were gavaged with THSWD for 1 week. The learning and memory abilities of the rats were measured by using the Morris water maze. Western blotting was used to detect the changes in DACD rat targets. Statistical methods were used to evaluate the correlation between proteins.
RESULTS: The results show that THSWD effectively reduced the escape latency, hippocampal neuron damage, glycosylated hemoglobin, type A1C, and blood lipid levels in DACD rats. Furthermore, DACD rats showed significantly increased amyloid precursor protein, β-secretase, Aβ1-40 , Aβ1-42 , Tau phosphorylation, and advanced glycation end products (AGEs) expression. However, THSWD treatment can reverse this phenomenon.
CONCLUSIONS: THSWD can improve the learning and memory abilities of DACD rats by inhibiting the expression of AEGs-AGE receptors pathway, which provides an experimental basis for the clinical application of THSWD. In addition, the experiment combines pharmacological and statistical methods, which offers a new perspective for the study of Chinese herbal medicine.
PROBLEM TO BE SOLVED: To obtain an oxidative hair dye containing the combination of a specific developing component with a coupling component, having an acidic to neutral pH value and capable of uniformly dyeing hair. SOLUTION: This oxidative hair dye contains the combination of 2-(2,5- diaminophenyl)ethanol or its water-soluble salt as a developing agent with a coupling agent (e.g. 4-chlororesorcinol) in an amount of 0.1-8 wt.% in a hair dye component mixture. Additives such as a direct dye (e.g. picramic acid), an antioxidizing agent (e.g. ascorbic acid), a perfume, a complex-forming agent, a wetting agent, an emulsifier and a thickener are further suitably added. The dye component mixture is mixed with an oxidizing agent (e.g. hydrogen peroxide) in a weight ratio of 5:1 to 1:3 at a pH of <=8, preferably 5.0-6.9, just before used. The dyeing of hair is carried out by coating hair with a sufficient amount of the mixture and subsequently leaving the coated hair at 15-50 deg.C for 10-45 min. A blue color or a red color in addition to a natural color can be developed.
Participants diagnosed with MM who have received treatment within 12 months preceding the enrollment will be observed prospectively. Data will be collected from the participants medical charts and via electronic case report forms (eCRFs).
Porcine epidemic diarrhea virus (PEDV) is an acute and highly contagious porcine enteric coronavirus. It has caused serious economic losses of pig industry in China. Here we insolated a current PEDV field strain named GS2022, analyzed the characters of genetic variation and pathogenicity. The results demonstrated that the GS2022 strain was belong to a newly defined subgroup G2 d, forming an independent branch which mainly contains strains isolated in China from 2017 to 2023. Notably, there are multiple mutations and extensive N-glycosylation compared to CV777 strain and PT-P5 strain, therefore the structure of GS2022 strain is different from 6U7K and 7W6M. Animal pathogenicity test showed that GS2022 strain could cause severe clinical signs and the high level of virus shedding in 7-day-old piglets. But recovery of diarrhea after 5 days, and no pathological damage to important organs. Further study on 3-day-old piglets also indicated GS2022 strain have pathogenicity. In this study no piglets died, which make it possible for that GS2022 strain become a candidate vaccine. These results are helpful to understand the epidemiology, molecular characteristics, evolution, and antigenicity of PEDV circulating in China. It also provides reference for designing effective vaccines against PEDV.
In this study we retrospectively reviewed our clinic's treatment of unilateral condylar hyperactivity (UCH). We used computer-guided proportional condylectomy, which was conducted both through preauricular and intraoral approaches, then analysed the advantages and disadvantages of the two techniques. A computer-guided treatment algorithm is also presented. We enrolled 42 patients diagnosed with clinical asymmetry, with or without associated dentofacial deformities, which had been confirmed by single photon emission computed tomography (SPECT) to be UCH. These patients underwent proportional condylectomy: 26 of them had isolated proportional condylectomy, while 16 had proportional condylectomy with concomitant orthognathic surgery. The intraoral approach demonstrated a capacity and precision that was nearly equivalent to the extraoral approach. This mitigates the significant surgical risks associated with the extraoral approach, but it is important to acknowledge the learning curve associated with the intraoral approach. Utilising virtual surgical planning (VSP) and custom cutting guides is essential.
The invention discloses complete and nutrient tea and a production method thereof. The complete and nutrient tea is prepared by utilizing the materials such as astragalus membranaceus, ginseng, codonopsis pilosula, Chinese date, lycium barbarum, Chinese yam, rhizoma polygonati, schisandra chinensis, rhizoma gastrodiae, radix ophiopogonis and fruit meat. The main process flow comprises the following steps of selecting the materials, drying, crushing, batching, removing impurities, sterilizing, quantifying, and packaging to obtain a finished product. The complete and nutrient tea and the production method disclosed by the invention have the beneficial effects that on the basis of the secret prescription handed down from ancestors, by taking and clinical verification of multiple cases as well as continuous summarization and perfection, the formula is more complete, the curative effect is exact, and the effect for the main diseases such as qi deficiency and weakness, epersalgia and asthenic disease, weak cough and rapid respiration are achieved; the effects for invigorating qi and strengthening superficies, nourishing vitality, invigorating spleen-stomach and replenishing qi, nourishing liver and kidney and strengthening spleen and nourishing lung are achieved by different degrees; and the complete and nutrient tea has the advantages of health care, reduction of blood fat, reduction of internal heat, induction of diuresis, pure natural and no toxic or side effect and the like. A product disclosed by the invention has the effects that different nourishing effects can be configured according to different groups, and different fruit pulps can be added according to different constitutions so as to improve the internal circulation of a body and enhance the resistance. The complete and nutrient tea can be directly brewed and drunk, is suitable for being used as tea substitutes for drinking, also can be added with green tea or black tea in brewing so as to increase the effects of the drink and enhance the nourishing effect.
The present invention relates to quick-acting mosquito-repellent antipruritic liquid and a preparing method, which belongs to liquid for preventing mosquito bite and a preparation method thereof. The liquid is prepared from thirty kinds of traditional Chinese medicine and is mainly composed of lilac flower, costustoot, liquorice, angelica, bidentate achyranthes root, honeycomb of paper wasps, Chinese honeylocust fruit, honeysuckle flower, alcohol, etc. In the preparation method, the traditional Chinese medicine is ground into powder mainly, and the powder is placed in alcohol to be soaked. The quick-acting mosquito-repellent antipruritic liquid has the advantages of favourable effect on disinsection and itching relieving, broad application, no stimulation to skin, no side effect and no pollution to the environment. After people is bite by mosquitos, the liquid is spread on affected parts, and the functions of phyma elimination, itching relieving and pain alleviation can be performed in several minutes. The quick-acting mosquito-repellent antipruritic liquid has optimal effect on infants and has certain therapeutic effect on pruritus cutanea caused by various reasons. The present invention also has the advantages of convenient use, simple dilution or direct spreading, low cost, easy production, etc., and is ideal quick-acting mosquito-repellent antipruritic liquid for families.
A soluble fiber lozenge in includes a body that is partially or wholly receivable in an oral cavity. The body includes a soluble-fiber matrix and one or more additives in the soluble-fiber matrix. A soluble fiber lozenge provided herein includes at least 40 weight percent of soluble fiber. Soluble fiber in soluble fiber lozenge can include maltodextrin. The soluble fiber lozenge is adapted to release one or more additives from the body when the body is received within the oral cavity of a consumer and exposed to saliva. A method of making soluble fiber lozenges includes forming a molten mixture of at least 40 weight percent soluble fiber, one or more additives, and less than 15 weight percent water while maintaining a mixture temperature of less than 200° C. and portioning the molten mixture into a plurality of soluble fiber lozenges.
The present technique relates to an information processing device, method, and program which are able to improve security. A data server and systems at pharmacies are connected via a communication network. The data server associates and registers individual identification ID for identifying users, dispensing pharmacy identification ID for identifying systems at pharmacies, dispensing pharmacy user identification ID for identifying users of a pharmacy system, and user drug history data. When drug history data is referenced, the system at a pharmacy sends individual identification ID and dispensing pharmacy identification ID to the data server, and the data server acquires the drug history data and dispensing pharmacy user ID identified by this information. Because information directly identifying users does not have to be exchanged by the data server and the system at the pharmacy, security can be improved. The present technique can be applied to other information processing systems.
Patients data was obtained from the Department of Orthodontics, Armed Forces Institute of Dentistry, Rawalpindi. One Hundred and ten patients were included in the study, which were divided into two groups, 55 patients in each group, based on method of controlling pain during debonding. To control pain during debonding in one group , teeth were stabilized with finger pressure with cotton between finger and teeth and then debonding using open mouth technique was done. In second group teeth were stabilized using a plastic wafer between maxillary and mandibular teeth and then debonding was done using closed mouth technique. In order to reduce biasness, all of the patients were debonded with same plier and with wires still ligated to brackets. With the help of VAS, pain score was measured after debonding. A single operator performed complete procedure of debonding and pain recording.
A synthetic calcium phosphate based biomedical material comprises gadolinium. At least some of the gadolinium is in the form of Gd<3+> ions. The biomedical material may further comprise silicon and/or silicate. The material may comprise a compound having the general chemical formula Ca10-yGdy(PO4)6-x(SiO4)x(OH)2-x+y where 0 < x < 1.3 and 0 < y < 1.3. The phase purity of the biomedical material may be at least 95%. Also claimed is a biomedical material comprising a synthetic gadolinium-silicate co-substituted calcium phosphate based material. Also there is a process disclosed for making the biomedical materials comprising providing calcium or calcium containing compound, a gadolinium containing compound, a phosphorus containing compound and optionally a silicon containing compound and forming a precipitate by reacting the compounds in an aqueous phase at an alkali pH.
Patients will be administered fludarabine phosphate intravenously (IV) over a 30-minute period on days -4 to -2. Additionally, cyclophosphamide will be administered intravenously (IV) over 60 minutes on day -2. Subsequently, patients will receive BCMA/CD19 CAR T cells intravenously (IV) over a duration of 10-20 minutes on day 0. Patients who exhibit positive responses to the initial dose of BCMA/CD19 CAR T cells, do not experience unacceptable side effects, and have a sufficient quantity of cells available may be eligible to receive 2 or 3 additional doses of BCMA/CD19 CAR T cells.