anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study investigated sound localization abilities in patients with bilateral conductive and/or mixed hearing loss (BCHL) when listening with either one or two middle ear implants (MEIs). Sound localization was measured by asking patients to point as quickly and accurately as possible with a head-mounted LED in the perceived sound direction. Loudspeakers, positioned around the listener within a range of +73°/-73° in the horizontal plane, were not visible to the patients. Broadband (500 Hz-20 kHz) noise bursts (150 ms), roved over a 20-dB range in 10 dB steps was presented. MEIs stimulate the ipsilateral cochlea only and therefore the localization response was not affected by crosstalk. Sound localization was better with bilateral MEIs compared with the unilateral left and unilateral right conditions. Good sound localization performance was found in the bilaterally aided hearing condition in four patients. In two patients, localization abilities equaled normal hearing performance. Interestingly, in the unaided condition, when both devices were turned off, subjects could still localize the stimuli presented at the highest sound level. Comparison with data of patients implanted bilaterally with bone-conduction devices, demonstrated that localization abilities with MEIs were superior. The measurements demonstrate that patients with BCHL, using remnant binaural cues in the unaided condition, are able to process binaural cues when listening with bilateral MEIs. We conclude that implantation with two MEIs, each stimulating only the ipsilateral cochlea, without crosstalk to the contralateral cochlea, can result in good sound localization abilities, and that this topic needs further investigation.
The central angle (alpha) between two adjacent notches (1,2,3) measured from notch centre to notch centre is smaller than the central angle (beta) between the opening (4) of the ring and the two adjacent notches (1,3) measured from the centre of the opening to the centre of the notch. The sections (5,6,7,8) of the ring tablet have the same volumes. An even or odd number of sections of the ring can be provided. One of the notches (2) is located diametrically opposite to the opening (4). The opening is wedge-shaped limited by end surfaces (9,10) of the open ring. The opposing distance of the end surfaces to the inner edge (11) of the ring tablet is the smallest and to the outer edge (12) of the tablet is the greatest.
PURPOSE: Segmentation of ossified ligamentum flavum (OLF) plays a crucial role in developing computer-assisted, image-guided systems for decompressive thoracic laminectomy. Manual segmentation is time-consuming, tedious, and label-intensive. It also suffers from inter- and intra-observer variability. Automatic segmentation is highly desired.
METHODS: A two-stage, localization context-aware framework is developed for automatic segmentation of ossified ligamentum flavum. In the first stage, localization heatmaps of OLFs are obtained via incremental regression. In the second stage, the obtained heatmaps are then treated as the localization context for a segmentation U-Net. Our framework can directly map a whole volumetic data to its volume-wise labels.
RESULTS: We designed and conducted comprehensive experiments on datasets of 100 patients to evaluate the performance of the proposed method. Our method achieved an average Dice similarity coefficient of 61.2 ± 7.6%, an average surface distance of 1.1 ± 0.5 mm, and an average positive predictive value of 62.0 ± 12.8%.
CONCLUSION: To the best knowledge of the authors, this is the first study aiming for automatic segmentation of ossified ligamentum flavum. Results from the comprehensive experiments demonstrate the superior performance of the proposed method over the state-of-the-art methods.
The present invention provides a new use or method of use of a thylakoid extract, for oral route of administration, and a composition comprising the thylakoid extract in adjunction with an acceptable carrier for oral administration. Besides the pharmaceutical use, the thylakoid extract enters the composition of food or food supplements, or medication for its innocuity and its capacity to provide a diet enriched in anti-oxidants and anti-inflammatory compounds. Therefore, in accordance with the present invention is provided the use of athylakoid extract in the making of an oral composition for treating preventing a disease or disorder involving the formation of reactive oxygen species or inflammation. Also is provided a method for treating or preventing a disease or disorder involving the formation of reactive oxygen species inflammation in an individual, which comprises the step of orality administering an effective dose of a thylakoid extact. Further is provided an oral composition comprising a thylakoid extract and a vehicle for oral ingestion or oral administration. An oral composition comprising purified thylakoids and a carrier for oral ingestion or oral administration, with the proviso that the carrier does not essentially consists of water, physiological saline or propylene glycol is also provided as food or a food supplement, or as a peliet, or encapsulated granules or powder. The carrier may be present in an amount of 0.01% to 95% (w/w) of the total composition. The purified thylakoids are present in an amount which achieves a dosage of 0.1 to 10 mg per Kg of a subject's body weight.
Patients will receive acute lymphoblastic leukemia (ALL) -based chemotherapy and are permitted to receive allogeneic hematopoietic stem cell transplantation (HSCT) in CR. Otherwise, they will finish the consolidation chemotherapy. Patients with t(9;22) will receive chemotherapy combined with tyrosine kinase inhibitors.
INTRODUCTION: Huntington's disease (HD) stands as an inherited and progressive neurodegenerative ailment distinguished by chorea-esque movement patterns, which manifest as archetypal symptoms. The presence of pronounced psychiatric onset symptoms in patients can considerably amplify the intricacies of accurate diagnosis.
CASE PRESENTATION: A 43-year-old gentleman was admitted with a five-year chronicle of delusions, hallucinations, and irritability. He had previously received a diagnosis of schizophrenia and had been subjected to a regimen of antipsychotic medications for a span exceeding four years. However, subsequent to the application of cerebral MRI and genetic testing, his condition was conclusively redetermined as HD.
CONCLUSION: The salient attribute of this case resides in the deferred diagnosis of HD attributable to the presence of acute psychiatric initial symptoms, a scenario bearing noteworthy ramifications for disease oversight and prognostication. This instance warrants attentive scrutiny and discourse within the professional community.
PURPOSE:To inspect quickly and exactly the presence or absence of missing in the eighth factor and to diagnose hemophilia by using a specific antihuman eighth factor antibody for blood clotting which is sensitized with animal red blood cells, a buffer, and a standard eighth factor positive control and negative control for blood clotting in combination. CONSTITUTION:The measuring reagent ( I ) prepd. by combining a reagent formed by freeze drying the immobilized red blood cells which are the goat red blood cells sensitized with the specific antihuman eighth factor obtd. by immunizing the eight factor for clotting human blood (antifactor for hemopilia disease) with a rabbit, etc. ( I ), a specific phosphoric acid buffer (II), a standard positive control including the human eighth factor subjected to sterilized filtration (III), and a negative control (IV) in which the human eighth factor antibody subjected to the sterilized filtration and the eighth factor include both negative human blood serum is used. The freeze dried reagent of the refined human eighth factor antibody subjected to the sterilized filtration is prepd. for the purpose of specific decision. The above-described sensitized red blood cells are added to the double double dilution column and the simular dillution column of the positive and negative controls of the plasma to be inspected and the pressence or absence of clotting is observed. The max. dilution multiple at which the clotting is observed when compared with the positive control with respect to the test to be examined is determined as the human eighth factor value. The eighth factor value is thus measured exactly.
Patients with newly-diagnosed multiple myeloma (MM) may be treated using monthly cycles of dexamethasone plus thalidomide (DT). Unfortunately, the use of conventional doses of DT is associated with significant treatment-related morbidity and mortality, which is comparable to that observed with conventional chemotherapy. Hence, for safety reasons, patients frequently receive lower than conventional doses of DT (i.e. dt), and potentially experience a poorer anti-MM effect. The highly-potent aminobisphosphonate, zoledronic acid (Z), has been shown in pre-clinical mouse models to exhibit an impressive anti-MM effect. It is therefore possible to combined dt with Z (i.e. dtZ) to enhance the efficacy of (lower dose) dt. In addition, the anti-tumor effect of dtZ may potentially be augmented by using Z at a higher (three-weekly) dosing frequency.
It has been discovered that granulocyte macrophage colony stimulating factor ('GM-CSF') promotes migration of activated (but not differentiating) keratinocytes to wound sites. It was also discovered that GM- CSF increases the quantity and improves the quality of collagen. This growth factor specifically increases migration of keratinocytes of the 'wound' phenotype but does not have significant effects upon differentiated keratinocytes. Examples demonstrate reversal of skin impairment in multiple animal models of diabetic skin imparment when provided in an effective amount over an effective time period. The examples also demonstrate the efficacy of the formulations in cosmetic applications. A preferred formulation is a sustained release formulation that delivers sufficient growth factor to the skin and the underlying tissue thereof to increase the rate of keratinocyte migration, as well as collagen deposition and fibroblast proliferation, in the skin to promote rejuvenation of skin injuries resistant to repair due to underlying disease, such as diabetes, or aging.
INTRODUCTION: This protocol describes a systematic review and meta-analysis to evaluate the clinical effects of mixing short- and long-acting local anaesthetics in peripheral nerve blocks. Clinicians often combine short- and long-acting local anaesthetics to achieve a briefer onset time. However, this may come with a prize, namely a shorter total duration of the block, which is of clinical importance.
OBJECTIVE: This systematic review aims to strengthen the knowledge of the clinical effects associated with this practice. The primary outcome is the duration of block analgesia. Secondary outcomes are block onset time, sensory and motor block duration. Exploratory outcomes are postoperative pain scores, cumulative 24-h opioid consumption and the prevalence of serious adverse events.
METHODS: We will conduct a meta-analysis of the extracted data, and the risk of bias for each study will be evaluated. We will perform a Trial Sequential Analysis, subgroup, and sensitivity analyses and assess the overall risk of publication bias. Finally, we will evaluate the review using the GRADE principles.
Subjects will be administered placebo once daily via the ELLIPTA® dry powder inhaler (DPI) for 24 weeks. Subjects will also receive FF 100 mcg once daily, in the morning for 24 weeks. ELLIPTA is a registered trademark of the GSK group of companies.
PURPOSE:To obtain the titled suppressing agent to be used singly or added to a food and effective in suppressing the proliferation of oral bacteria causing dental caries and foul breath, by using a basic protein derived from soft-roe of fish or its salt, etc., as active component. CONSTITUTION:The objective agent for suppressing the proliferation of oral bacteria contains one or more kinds of components selected from a basic protein (protamine) derived from soft-roe of fish (e.g. salmon, herring, bonito, trout, etc.) or its salt as active components. The agent exhibits effective antibacterial activity against oral bacteria such as S. faecalis at pH 4-9 and can be used singly or in the form of a drug preparation, aqueous solution or food additive. Preferably, the agent is added to a chewing food such as chewing gum to keep the effect over a long period. It is also effective by applying to the surface of tooth in the form of cream. The necessary amount of the active component is >=0.005% for gargle, >=0.1% for food and >=0.005% for chewing gum. It can be used singly as a pure compound.
Castor oil is traditionally given by midwives in order to induce labor. Its efficacy as an initiator of labor was previously tested only in one clinical trial. Unfortunately this study (by Garry et al.) was not sufficiently controlled.

We intent to recruit 84 healthy pregnant women with no contraindication to vaginal delivery that had past their due date. Women will be randomly and blindly divided into equal sized intervention group and control group. Intervention group will be given 60 mL of castor oil in 140 mL of orange juice, while control group will be given a placebo with similar texture. Primary outcome to be tested is the percentage of women entering active labor within 24 hours of administration.
The invention discloses a traditional Chinese medicine preparation for treating exuberant fire and heat type radioactive salivary gland damage. In the traditional Chinese medicine theory, rays are taken as an external evil, can cause diseases having the characteristics of diseases caused by fire heat and diseases caused by toxic evil, can invade a person from the exterior surface and then penetrate to the internal organs, can directly damage the internal organs, and are a strong pathogenic factor. The preparation is made of the following traditional Chinese herbals having the functions of clearing heat, removing toxicity, nourishing yin, engendering liquid, cooling blood, and activating blood: chondrilla juncea, hairy holly leaf, oxalis corymbosa, winter sweet root, hippuris vulgaris, Japanese snake gourd root, longspurred fairybells rhizome, phymatopsis griffithiana, coelomactra antiquata, diospyros lotus, yellow fungus, and stenosolenium saxatile root. The decoction is prepared by decocting the raw materials mentioned above in water. The total effective rate of the preparation is 94.3%, and the curative effect is prominent. During the whole treatment course, no obvious adverse reaction happens, and no obvious change is observed in blood, urine, and stool routine examinations, electrocardiogram, liver function, and kidney function.
Determining whether an ectopic depolarization will lead to a self-perpetuating arrhythmia is of critical importance in determining arrhythmia risk, so it is necessary to understand what factors impact substrate vulnerability. This study sought to explore the impact of cell-to-cell heterogeneity in ion channel conductance on substrate vulnerability to arrhythmia by measuring the duration of the vulnerable window in computational models of one-dimensional cables of ventricular cardiomyocytes. We began by using a population of uniform cable models to determine the mechanisms underlying the vulnerable window phenomenon. We found that in addition to the known importance of GNa, the conductances GCa,L and GKr also play a minor role in determining the vulnerable window duration. We also found that a steeper slope of the repolarizing action potential during the vulnerable window correlated with a shorter vulnerable window duration in uniform cables. We applied our understanding from these initial simulations to an investigation of the vulnerable window in heterogeneous cable models. The heterogeneous cables displayed a great deal of intra-cable variation in vulnerable window duration, highly sensitive to the cardiomyocytes in the local environment of the ectopic stimulus. Coupling strength modulated not only the magnitude of the vulnerable window duration but also the extent of intra-tissue variability in vulnerable window duration.NEW & NOTEWORTHY We investigate the impact of cell-to-cell heterogeneity in ion channel conductance on substrate vulnerability to arrhythmia by measuring the vulnerable window duration in computational cardiomyocyte cable models. We demonstrate a wide range of intra-cable variability in vulnerable window duration (VWD) and show how this is changed by ion channel block and coupling strength perturbations.
OBJECTIVE: To explore the application and key points of microchannel approaches in resection of cervical intraspinal tumors.
METHODS: A retrospective analysis was performed on 51 cases of cervical spinal canal tumors from February 2017 to March 2020. Among them, 5 cases were located epidural space, 6 cases were located epidural and subdural space, and 40 cases were located under the subdural extramedullary space(6 cases were located on the ventral side of the spinal cord). The maximum diameter ranged from 0.5 to 3.0 cm. The clinical manifestations included neck, shoulder or upper limb pain 43 cases, sensory disturbance (numbness) in 22 cases, and limb weakness in 8 cases. The microchannel keyhole technique was used to expose the tumor, and the tumor was resected microscopically.
RESULTS: In this study, 35 patients underwent hemilaminectomy, 12 patients underwent interlaminar fenestration, 2 patients underwent medial 1/4 facetectomy on the basis of hemilaminectomy or interlaminar fenestration. Two tumors were resected through anatomy space (no bone was resected). The degree of tumor resection included total resection in 50 cases and subtotal resection in 1 case. The type of the tumor included 36 schwannomas, 12 meningiomas, 2 enterogenic cysts and 1 dermoid cyst. There was no infection and cerebrospinal fluid leakage postoperatively. Limb numbness occurred in 7 patients. The average follow-up time was 15 months (3 to 36 months). No deformity such as cervical instability or kyphosis was found. The tumor had no recurrence.
CONCLUSION: The cervical spinal canal is relatively wide, cervical tumors with no more than three segments can be fully exposed by means of microchannel technology. Besides intramedullary or malignant tumors, they can be microsurgically removed. Preservation of the skeletal muscle structure of cervical spine is beneficial to recover the anatomy and function of cervical spine. The electrophysiological monitoring helps to avoid spinal cord or nerve root injury.
ABSTRACT      Amplified signals in both existing and non-detected restriction fragments were observed with 3 different enzymes (PVU2, HindIII and EcoRI) in two different AMLM2 cases out of 5.  Most interestingly, the amplification of clone 14-hybridizable DNA was accompanied by amplification in BuChE positive sequences.  The fact that different sizes of the restriction fragments hybridized with the 3' probe excluded the possibility of cross-hybridization, Several of the amplified bands could be observed, with lower intensities, in the presumptive polycytemia vera (Vaguez disease) case or in one or two of the other AML cases.      The adr. sample represents a patient, currently under remission following chemotherapy treatment, whose serum and erythrocyte ChE were apparently normal in levels and biochemical characteristics.  ChE genes and clone 14 are both co-regulated and co-amplified under specific stimulants.
CBTI combines behavioral sleep strategies with cognitive therapy. It is the first-line treatment for insomnia as recommended by the American College of Physicians and the American Academy of Sleep Medicine. Behavioral sleep strategies include sleep restriction and stimulus control. Cognitive therapy includes scheduled worry time and challenging dysfunctional beliefs about sleep. CBTI consists of 6 60-minute sessions with a therapist along with self-monitoring with sleep diaries. All sessions are delivered via telemedicine during pregnancy.
The present invention, in some embodiments, describes methods for selecting and enriching specific types of stem cells and/or progenitor cells from a sample containing at least two different types of stem cells and/or progenitor cells. In one embodiment, the method involves selecting and enriching cancer stem cells and/or cancer progenitor cells. In other embodiments, the invention involves improved methods for purging cancer cells from autologous or allogenic transplants prior to reinjection into a patient. In other embodiments, the invention describes improved methods to screen for the efficacy of drug candidate for affecting the function and/or viability of a specific type of stem cell or progenitor cell, for example a cancer stem cell. In this context, the inventive method can involve screening the effectiveness of chemotherapeutic agents in completely eliminating all cancer cells (i.e. mature cancer cells and cancer stem/progenitor cells). In yet other embodiments, the invention provides methods for the identification of a particular type or sub-population of stem cells or progenitor cells from a mixed cell-type population. In one embodiment of such a method, the invention describes a method for the early detection of metastatic cancer from simple tests on blood or bone marrow. Stem cell culture methods are also disclosed which utilize cell lysates to preferentially induce either asymmetric or symmetric division of the stem cells. The invention also provides, in some embodiments, novel stem cell suspensions that include, in some instances enriched suspensions of particular types or sub-populations of stem cells or progenitor cells, for example cancer stem cells. In other embodiments, the invention provides a suspension of stem cells that is substantially free of all stem cells of a particular type or sub-population and, optionally, also substantially free of all mature cells. In one example of such an embodiment, the invention provides a suspension of stem cells that is substantially free of all cancer cells (i.e. mature cancer cells as well as cancer stem cells and cancer progenitor cells).
Exemestane 25 mg administered once daily was evaluated in a randomized double-blind, multicenter, multinational comparative study and in two multicenter single-arm studies of postmenopausal women with advanced breast cancer who had disease progression after treatment with tamoxifen for metastatic disease or as adjuvant therapy. Some patients also have received prior cytotoxic therapy, either as adjuvant treatment or for metastatic disease. 

The primary purpose of the three studies was evaluation of objective response rate (complete response [CR] and partial response [PR]). Time to tumor progression and overall survival were also assessed in the comparative trial. Response rates were assessed based on World Health Organization (WHO) criteria, and in the comparative study, were submitted to an external review committee that was blinded to patient treatment. In the comparative study, 769 patients were randomized to receive exemestane tablets 25 mg once daily (N = 366) or megestrol acetate 40 mg four times daily (N = 403). Demographics and baseline characteristics are presented in Table 9. 

The efficacy results from the comparative study are shown in Table 10. The objective response rates observed in the two treatment arms showed that exemestane was not different from megestrol acetate. Response rates for exemestane from the two single-arm trials were 23.4% and 28.1%. 

There were too few deaths occurring across treatment groups to draw conclusions on overall survival differences. The Kaplan-Meier curve for time to tumor progression in the comparative study is shown in Figure 2. 

Figure 2

Time to Tumor Progression in the Comparative Study of Postmenopausal Women With Advanced Breast Cancer Whose Disease Had Progressed After Tamoxifen Therapy