anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Although WHO declared the end of the public health emergency for coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), XBB lineages continue to evolve and emerge globally. In particular, XBB.1.5 and XBB.1.16 are raising concerns because of their high immune evasion, leading to apprehensions regarding vaccine efficacy reduction and potential reinfection. We aimed to investigate the COVID-19 outbreak in Korea and predict the likelihood of reinfection by testing neutralizing activity against live viruses from the S clade and 19 Omicron sublineages. We found a significant risk of infection with the currently prevalent XBB lineage for individuals who were either vaccinated early or infected during the initial Omicron outbreak. Vaccinated individuals were better equipped than unvaccinated individuals to produce neutralizing antibodies for other SARS-CoV-2 variants upon infection. Therefore, unvaccinated individuals do not easily develop neutralizing activity against other variants and face the highest risk of reinfection by the XBB lineage. Our study provides important information to facilitate the development of strategies for monitoring populations that would be the most susceptible to new COVID-19 outbreaks.
IASTM using tools over Myofascial trigger points of the length of targeted muscles (SCM, descending fiber of trapezius, suboccipitalis muscles) in a multidirectional stroking fashion applied to the skin at 30°- 60° for 5 minutes. Participants were in a comfortable position during treatment. Emollient (anti-allergic) was applied to prevent skin irritation prior to Fascial Abrasion application. Each session included 1 minute of sweeping (longitudinal strokes performed parallel to the muscle fibers similar to compression with oscillations) directly over the Myofascial trigger points, 2 minutes of fanning (one end of the instrument was held in place \& the other end moved through a semicircular pattern similar to petrissage) and concluded with 1 min of sweeping.
In a method and a device for optimization of a combined system for the acquisition of magnetic resonance tomographic measurement data and an image reconstruction process, the image reconstruction process is already executed during the acquisition of the measurement data, by the calculation process being deconstructed into calculation packets, and rules are defined that establish which requirements must be met for the execution of the respective calculation packet. The calculation process is reorganized into a workflow structure based on the calculation packets and the rules. The calculation process is controlled using the generated workflow structure synchronized to the acquisition process. The rules entirely describe the calculation process, i.e. inclusive of all calculation packets and their logical dependencies. The stability of the calculation process is thus entirely independent of the chronological order of the measurement data acquisition.
FIELD: medicine, gastroenterology, phytotherapy. SUBSTANCE: invention relates to agents used for treatment of patients with cicatrizing stomach ulcer complicated with associated pathology of gastroenteric tract. Agent can be used independently and in complex with other similar agents. Preparation is 40% alcoholic tincture prepared of medicinal species of the following composition, mas. p. p.: catchfly herb tatar or drooping, 12; medicinal pot-marigold flowers, 4; willow-herb narrow-leaved leaves, 4; matricary officinalis flowers, 1. Preparation shows anti-inflammatory effect on stomach mucosa, enhances reparation by effect on cellular immunity and metabolism in mucosa but not by effect on stomach secretory function. Agent can be used for treatment of patients with stomach ulcer with associated diseases. EFFECT: simplified method of preparing, high effectiveness, available components, decreased cost, absence of any adverse or nondesirable effects.
Chronic kidney disease (CKD) is a major health problem worldwide.(1) Chronic renal failure is defined as a decrease in glomerular filtration rate (GFR) of less than 60 ml/min/1.73 m2 of body surface evolving for more than 3 months . The etiologies of CKD in children are three main groups of pathologies: congenital anomalies of the kidney and urinary tract , hereditary nephropathies and acquired causes . (2) complication of pediatric hemodialysis is chronic fluid overload, left ventricular hypertrophy ,hypertension, heart failure, decrease arterial flexibility and often results in increase chance of morbidity and mortality, So fluid overload must be prevented .(3) Lung ultrasonography is the most recent, safe, easy, and reliable technique . The most commonly observed finding is a comet tail fanning out from the lung-wall interface and spreading upwards to the edge of the screen, named a "B-line" Chest sonar advantages include its noninvasiveness , ease of use, availability of portable machines, avoidance of radiation detect lung edema even in initial non symptomatic cases known as hidden lung congestion .(4) Bioimpedance analysis (BIA) Bio impedance spectroscopy (BIS) is a technique used to estimate total body water, extracellular water, lean and adipose tissue mass and over hydration . (5) N-terminal pro-brain natriuretic peptide is used as a biomarker to aid to predict cardiac dysfunction in children and adolescents .(6)it is an effective marker of volume status in patient with or without reduced ejection fraction undergoing hemodialysis. (7)
<P>PROBLEM TO BE SOLVED: To provide a genetically engineered cell and a genetically engineered animal capable of monitoring hypoxia response of a cell by preparing a vector detecting the hypoxia response and then expressing the same.  <P>SOLUTION: The invention relates to construction of a new expression cassette of hypoxia response by utilizing a hypoxia responsive element (HRE). The cell holding the expression cassette expresses an exotic gene by the hypoxia response. The hypoxia response of a cell is detected by using an expression of an exotic gene as an indicator. Thus the invention provides the method for screening compounds having hypoxia response regulating effect.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
BACKGROUND: Atrial fibrillation (AF) pattern, relevant cardiac changes are important predictors of outcomes in AF, but their impact on patients with ischemic stroke and AF remained unclear. We aimed to explore the impact of AF patterns, cardiac structural and functional markers on long-term functional and cognitive outcomes in ischemic stroke patients with AF.
METHODS: Ischemic stroke patients diagnosed with AF were enrolled in this retrospective cohort study. AF pattern was defined by both traditional and novel classification, in which patients were divided into AF diagnosed after stroke (AFDAS) and known before stroke (KAF). Left atrial (LA) diameter, left ventricular ejection fraction (LVEF), natriuretic peptide (BNP) and cardiac troponin (cTnI) were dichotomized according to the median value. Outcomes include poor functional outcome and cognitive impairment at the 1-year follow-up. Multivariable logistic regression was performed to validate the association between AF pattern, parameters of cardiac change and functional and cognitive outcome.
RESULTS: A total of 377 patients were included. Non-paroxysmal AF patients had a higher risk of poor functional outcome (OR = 3.59, P < 0.0001) and cognitive impairment (OR = 2.38, P = 0.019) than paroxysmal AF patients, while there were no differences between AFDAS and KAF. Lower LVEF (OR = 1.83, P = 0.045) and higher BNP (OR = 2.66, P = 0.001) were associated with poor functional outcome. Lower LVEF (OR = 2.86, P = 0.004), higher LA diameter (OR = 2.72, P = 0.008) and BNP (OR = 2.31, P = 0.023) were associated with cognitive impairment.
CONCLUSIONS: AF type and related cardiac markers can serve as predictors for poor functional and cognitive outcomes. Comprehensive cardiac assessment and monitoring should be strengthened after stroke.
It has been reported that many organic sunscreens lose their efficacy on exposure to UV rays. Further some of the organic sunscreens are known to interact with each other when applied on the skin with or without exposure to UV radiation. Thus such compositions are not stable. They are not very effective in blocking the UV-rays a few minutes or hours after the product has been applied to the skin. Further when such compositions are used and then exposed to sunlight or UV rays, the period over which the skin is actually protected is very short, while the consumer is under the mistaken impression that the composition is protecting his/her skin. This false impression can lead to the consumer exposing himself/herself more to sunlight thereby getting more damage to the skin. A solution to the foregoing problem is provided by a stable sunscreen composition comprising: (a) a complex of a first organic sunscreen with a first paramagnetic metal ion; and (b) a second organic sunscreen.
A mixture of an aqueous solution, essential oils and mechanically extracted Phaeophyte kelp cytoplasm results in an emulsion with cosmetic and therapeutic properties. The preparation may be used on human and animal hair or skin. The moisturizing properties of the kelp cytoplasm provide the aqueous solution to the hair (keratin) which is absorbed, causing the hair to swell, and become heavier and more pliable. The natural oxidation agent preserves the mixture as well as providing a fresh oxygen in a spray when used. The alginate gels and oils in the emulsion coat the hair strands to reduce breakage and splitting and add weight to the strand. The preparation dries with gel capsules, which release moisture over time for a long-lasting effect. The preparation also contains, and may be supplemented with fuciodans, iodine, phlorotannins which reduce inflammation, prevent scaly skin, and act as an antibiotic, respectively, on dry chapped skin. The preparation seals off the cracks from the environment while trapping moisture pockets. This provides an environment conducive for healing.
All patients with a significant stenosis (\>50% on coronary angiography) in a venous bypass graft discussed in the local heart team for revascularization will be screened for potential inclusion in the study. Percutaneous coronary intervention of the bypass graft will be performed following current standards and at the discretion of the operating interventional cardiologist. Only commercially available second generation DES will be used in the treatment of bypass grafts. The second generation DES used in this study will be the XIENCE Sierra stent. The use of a filter-wire during the procedure will be left at the discretion of the operator.
Trophectoderm cells will be analyzed by NGS. Culture media will also be stored for further non-invasive chromosomal testing. Embryo selection will be done according to international guidelines (www.pgdis.org; Newsletter May 27, 2019).
An external wound medicine and a preparation method thereof belong to the field of external wound medicine, and comprise the following substances in mass volume ratio: 100 parts of oleaster leaves; 100-150 parts of deionized water; 0.025-0.075 parts of tetrahydropiperine. The invention has the advantages that: the invention mixes deionized water and oleaster leaves, carries out microwave wall breaking extraction, presses all materials after completion to obtain extract liquid through a press filter, and then carries out low-temperature negative pressure drying to obtain medicinal powder. The powder obtained by microwave wall breaking extraction has obvious medicinal effect improvement through a rat wound-healing test and comparison with the data of a traditional test. Then adding plant penetrating agent into water, and further improving the efficacy of the extract. The technology is commercialized and industrialized, the water consumption is further reduced, the drying time is shortened, and the pharmaceutical energy consumption is greatly reduced. So far, chinese products are marketed and applied to pets, poultry and livestock to obtain obvious application results.
The present invention relates to panaxadiol and its derivative, its preparation method and medicinal uses, belongs to natural medicine field, more specificly relating to dammar-20-(22)-ene-3 beta, 12 beta,25-triol. The molecular formula is : C30H52O3. The molecular weight is  460. The panaxadiol and its derivative preparation method comprise acid degradation preparation method and alkaline degradation preparation method and purification step. The acid degration of ginseng root general ginsenoside proceed in organic solvent acid aqueous solution containing protecting agent, while the alkaline degration of ginseng root general ginsenoside proceed in organic solvent acid aqueous solution. The present invention also relates to uses of the panaxadiol in preparing assistant drug for treating senile dementia, cerebral vascular dementia and tumour treatment. The beneficial effect : the drug prepared from panaxadiol has obvious curative effect for treating senile dementia, cerebral vascular dementia and tumour treatment.
Generalized anxiety disorder (GAD) is a highly prevalent, chronic psychiatric disorder. Despite the fact that GAD frequently demands prolonged treatment with medication, very little is known about the benefits of long-term treatment. GAD is characterized by 6 months or more of exaggerated worry and tension that is unfounded or much more severe than the normal anxiety most people experience. People with GAD are unable to relax and often suffer from insomnia. Venlafaxine XR, a drug used to treat depression, has been shown to be effective in the short-term treatment of GAD. However, its benefits over a course of more than 8 weeks have not been assessed. This study will evaluate the effectiveness of venlafaxine XR in treating GAD on a long-term basis and preventing the relapse of GAD after 6 months of treatment versus 12 months of treatment.

Participants in this double-blind study will first receive 6 months of open-label treatment with venlafaxine XR. Upon completion of this initial phase, participants will be randomly assigned to either continue on venlafaxine XR or begin taking placebo. After 12 months, participants taking venlafaxine XR will be randomly assigned to continue on the drug or switch to placebo. Participants will have 22 study visits over at least 18 months. Follow-up visits will occur 24 months after enrollment. Relapse of GAD will be assessed with the Hamilton Anxiety Scale and Global Severity and Improvement Scale. A variety of methods, including questionnaires and standardized scales, will be used to assess secondary outcomes.
A system may receive a plurality of digital histology images, wherein each of the plurality of digital histology images is labeled with a respective image-level classification. A system may extract a plurality of tiles from each of the plurality of digital histology images. A system may create a first dataset comprising the plurality of tiles and respective image-level classifications. A system may train a first machine learning model using the first dataset. A system may create a second dataset by sampling the first dataset based on respective classifications and respective uncertainty measures for each of the plurality of tiles output by the trained first machine learning model. A system may train a second machine learning model using the second dataset, wherein the trained second machine learning model is configured to classify one or more tiles of a digital histology image.
Intravenous hydromorphone 1mg. A second dose can be administered at 30 minutes.
The co-occurrence of bruxism, temporomandibular disorders (TMDs), and headache is common in patients. However, there is conflicting evidence regarding whether this association is simply a result of their high prevalence or whether there are indeed causal relationships. This review provides an overview of the current state of research while taking into account the controversies surrounding research methods, particularly in definitions and diagnostic standards. Bruxism-defined as repetitive jaw muscle activity during sleep or wakefulness-is not a painful disorder but may-particularly in co-occurrence with TMD-worsen pre-existing headache. It seems important to differentiate between sleep and awake bruxism because of different impact on pathophysiological processes in different primary headache disorders such as migraine and tension-type headache. Temporomandibular disorder is a heterogenous entity with both myofascial and arthrogenous types of pain in addition to nonpainful disorders. Research suggests a correlation between TMD pain and migraine, as well as between awake bruxism and tension-type headache. However, psychosocial factors may act as confounders in these relationships. Determining causality is challenging because of the limited number of experimental and clinical studies conducted on this topic. The main finding is an apparent lack of consensus on the definition and assessment criteria for bruxism. Treatment wise, it is important to differentiate all 3 conditions because treatment of one condition may have an effect on the other 2 without proving causality. For future research, it is crucial to establish greater consistency and applicability in diagnostic procedures and definitions. In addition, more experimental and clinical studies investigating the question of causality are needed.
BACKGROUND: The current standard of drawing two vs three blood culture sets lacks adequate guidance. Because people who inject drugs are at higher risk for bacteraemia and life-threatening infection, consideration of a third blood culture becomes more important.
AIM: To investigate the risks and benefits of obtaining two versus three blood culture sets.
METHODS: Retrospective cohort study of adults who inject drugs at a multicentre catch-net hospital system from 2017-2022.
FINDINGS: 998 people who inject drugs and 2278 blood culture sets were analysed. There were 1618 episodes with two blood culture sets and 660 episodes with three. A potential benefit of adding a third blood culture was seen in 30 (4.5%) episodes. However, only 13 (2.0%) episodes showed pathogen-identifying benefit, as 17 (2.6%) involved known inadequately treated infections or the same pathogen in another culture. The number of blood culture sets needed to achieve diagnostic benefit was 51. There were more contaminants for three blood culture sets (65, 9.8%) than for two (114, 7.0%) (p < 0.00001). By adding a third blood culture, the risk of a contaminant increased by 39.7%; the number of blood culture sets needed to find a contaminant was 36. Of 122 episodes with only contaminants and available for analysis, 111 (91.0%) experienced at least one complication. 33 (27.0%) patients experienced either prolonged admission, readmission, or unnecessary antibiotic administration.
CONCLUSIONS: The benefits of possibly isolating a pathogen from a third blood culture set do not universally outweigh the risks for contaminant growth for people who inject drugs. A third blood culture should be considered in specific clinical scenarios (i.e. inadequately treated endocarditis and osteomyelitis).
An electronics module for a wearable article is arranged to monitor one or more performance parameters during a physical activity conducted by a user. The module comprises a processor, memory and a wireless communicator, wherein the memory stores instructions that are executable by the processor. The communicator is arranged to receive S201 audio output device communication information from an intermediary electronics device, the audio output device communication information facilitating communication with an audio output device. The processor is arranged to generate S203 an audio signal, and the communicator is arranged to communicate S204 the audio signal to the audio output device using the audio output device communication information. A sensing component may comprise an electrode to measure biosignals, such as electrocardiogram signals, of the wearer during exercise. The communicator may be arranged to receive S201 an audio identified for the user of the intermediary electronics device, and wherein the generated audio signal may comprise the received audio identifier.
Subcutaneous human adipose tissue is an abundant and accessible cell source for applications in tissue engineering and regenerative medicine. Methods to extract stromal/stem cells from the waste products of abdominoplasty, cosmetic surgery, and liposuction are now well developed. Routinely, the adipose tissue is digested with collagenase or related enzymes to release a heterogeneous population of SVF cells. The SVF cells can be used directly or can be cultured in plastic ware to select and expand an adherent population known as adipose-derived stromal/stem cells.

Osteoarthritis is the most common joint disease that affects at least 20% of the world population. The disease usually begins at the age of 40 years. Radiographic signs of osteoarthritis are diagnosed in 50% of people aged 55 years and 80% - over 75 years. OA can cause severe pain and stiffness in the affected joints, thus reducing joint's functionality. Therefore a treatment that would reduce pain/stiffness and increase joint function would be of benefit to many people. Safety and feasibility of SVFs in OA patients have been shown in few clinical studies.

This trial is a prospective, controlled, non-randomized, non-blinded, interventional study to determine safety and efficacy of a single injection of freshly isolated autologous SVFs into the knees of osteoarthritic patients (Grade II-III). In experimental group the participants (n=16) will undergo a standard liposuction to harvest adipose tissue, then the adipose tissue will be processed to obtain the SVFs and patients will receive a single intra-articular injection of auto-SVFs into affected knees under the ultrasound navigation. In parallel control group the participants (n=11) will receive a single intra-articular injection of hyaluronic acid (Synocrom Forte 2%) under the ultrasound navigation. The safety of auto-SVFs injection will be evaluated by assessment of the frequency and nature of adverse events occurring during or immediately after the procedure, and up to the one year following treatment. Patients will be monitored during 1, 3, 6 and 12- month's visits.
To provide a method for reducing a burden on a subject and easily estimating a serum zinc value in the subject.SOLUTION: Means for solving the problem of the present invention are as follows. 1. A method for estimating a serum zinc value from a zinc value in saliva and/or a feeling profile test value. 2. The method for estimating a serum zinc value according to 1., wherein the feeling profile test is POMS or POMS2. 3. A system for estimating a serum zinc value in the subject by using the method for estimating a serum zinc value according to 1. or 2., and providing the subject with a zinc sufficient state and/or an oral composition for compensating for the shortage of zinc. A method for estimating a serum zinc value from a zinc value in saliva and/or a feeling profile test value.SELECTED DRAWING: Figure 1
A substantially pure and isolated DNA fragment having a nucleic acid sequence as shown in SEQ ID NO. 1 or SEQ ID NO. 2, and a substantially pure peptide having an amino acid sequence selected from the group consisting of SEQ ID NO. 3, SLS, SEQ ID NO. 4, SQD, SLL, SEQ ID NO. 5, SEQ ID NO. 169 and SEQ ID NO. 170 are provided. Also provided are vaccines, antibodies and pharmaceutical compositions generated from at least one of the DNA fragments and/or peptides. Further provided are methods for detecting and/or treating rheumatoid arthritis.
A loading infusion of the 50 ml syringe (A) containing normal saline was started at rate of 0.2 ml/ kg/hr ten minutes before induction (as masking for mixture in group S). Then anesthesia was induced with 2 mg/kg ideal body weight (IBW) of propofol , patients were intubated with the aid of 0.5 mg/kg IBW atracurium and received 0.1ml/kg from syringe (C) containing fentanyl (1 mic/kg of IBW).