anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Subjects will receive 6 doses of intravenous Epo 1000 U/kg/dose at 48 hour intervals from the time of enrollment. Following the high dose period, subjects will receive subcutaneous Epo 400 U/kg/dose three times a week until 32-6/7 weeks postmenstrual age.
Disclosed herein is a computer implemented method and system that addresses the need for an online disease based and case based management of medical care. An online disease and case management system is provided. The information of the patients is retrieved from multiple information sources. The patient information is used to identify one of a disease condition in a patient population and a patient with a disease condition. Further, the patients are enrolled. The enrolled patients are educated about the disease condition for self monitoring of the disease condition. The status of the self monitored disease condition is recorded in a disease log. Visits to a provider are scheduled for medical treatment of the enrolled patients. The enrolled patients are monitored for medical progress based on the medical treatment provided. Further, the disease and case management of medical care are evaluated and reported based on clinical and financial outcomes.
FIELD: medicine.SUBSTANCE: invention relates to medicine, in particular to cosmetology, dermatology and plastic surgery. A preliminary determination is carried out at the stage of planning the procedure for the topography of the facial artery and vein crossing the bony edge of the lower jaw in its lateral part. For this, the patient is tested in a sitting position during chewing, in which the anterior edge of the superficial portion of the chewing buccal muscle is first palpated at the level of the marginal edge of the lower jaw. Then the point of intersection of the muscle indicated above and the marginal edge of the lower jaw is palpated. According to the results of palpation, the topography of the facial artery is determined and marked on the projection of the mandible body, and the facial vein is marked taking into account its location 1 cm distal to the artery. Then, in a sitting position, measurements of the parameters of the angle of the lower jaw, which will be different depending on the gender of the patient, are made, and markings are made for the vectors of filler injection. After that, a blunt-pointed cannula with a diameter of at least 22G and a length of 5 cm is punctured into the access point on the projection of the apex of the angle of the lower jaw formed by its branch and body to a depth of 2-3 mm, providing a subcutaneous level of subsequent deposition of the drug, and guiding it at the level of superficial fat packets into the marked vectors of tissue volume deficit, and the injection is carried out in a vector anterograde technique at the rate of 4 vectors coming from one access point per area with an average filler volume of 2 ml.EFFECT: method makes it possible to safely and effectively restore the natural contours, positions and volume of the lower jaw inherent in young age.1 cl, 3 dwg, 1 ex
The participant will complete six consecutive weeks of SLT accompanied with sham tDCS. Each session starts with 20 minutes of tDCS followed by the SLT program.
A method for the complex treatment of the gingivitis in the pregnant women comprises the elimination of the dental deposits. In addition, in trimester II the individually developed algorithm for the hygiene of the oral cavity is provided using the complex based on the products of apiculture as well as the extracts of the medicinal herbs affecting the oral mucosa and the body as a whole. For the topical treatment of the oral mucosa, Tonzinal is used as a solution of of the powder in 100 mL of the warm water for applications and rinsing the oral cavity 3-6 times a day for 7 days. Proposol is used for aerosol applications onto the gums for 15 minutes after the morning hygiene of the oral cavity. CM-2 plates with calcium are used after the evening hygiene of then oral cavity for 7 days. For the general prophylaxis, Apilac in tablets is used at a dose of one tablet sublingually twice a day for 7 days.
Ropivacaine hydrochloride, 5 mg/mL (0.5%), was evaluated for its ability to provide anesthesia for surgery using the techniques of Peripheral Nerve Block. There were 13 studies performed including a series of 4 pharmacodynamic and pharmacokinetic studies performed on minor nerve blocks. From these, 235 Ropivacaine hydrochloride-treated patients were evaluable for efficacy. Ropivacaine hydrochloride was used in doses up to 275 mg. When used for brachial plexus block, onset depended on technique used. Supraclavicular blocks were consistently more successful than axillary blocks. The median onset of sensory block (anesthesia) produced by ropivacaine 0.5% via axillary block ranged from 10 minutes (medial brachial cutaneous nerve) to 45 minutes (musculocutaneous nerve). Median duration ranged from 3.7 hours (medial brachial cutaneous nerve) to 8.7 hours (ulnar nerve). The 5 mg/mL (0.5%) Ropivacaine hydrochloride solution gave success rates from 56% to 86% for axillary blocks, compared with 92% for supraclavicular blocks.

In addition, Ropivacaine Hydrochloride, 7.5 mg/mL (0.75%), was evaluated in 99 Ropivacaine hydrochloride-treated patients, in 2 double-blind studies, performed to provide anesthesia for surgery using the techniques of Brachial Plexus Block. Ropivacaine hydrochloride 7.5 mg/mL was compared to bupivacaine 5 mg/mL. In 1 study, patients underwent axillary brachial plexus block using injections of 40 mL (300 mg) of Ropivacaine hydrochloride, 7.5 mg/mL (0.75%) or 40 mL injections of bupivacaine, 5 mg/mL (200 mg). In a second study, patients underwent subclavian perivascular brachial plexus block using 30 mL (225 mg) of Ropivacaine hydrochloride, 7.5 mg/mL (0.75%) or 30 mL of bupivacaine 5 mg/mL (150 mg). There was no significant difference between the Ropivacaine hydrochloride and bupivacaine groups in either study with regard to onset of anesthesia, duration of sensory blockade, or duration of anesthesia.

The median duration of anesthesia varied between 11.4 and 14.4 hours with both techniques. In one study, using the axillary technique, the quality of analgesia and muscle relaxation in the Ropivacaine hydrochloride group was judged to be significantly superior to bupivacaine by both investigator and surgeon. However, using the subclavian perivascular technique, no statistically significant difference was found in the quality of analgesia and muscle relaxation as judged by both the investigator and surgeon. The use of Ropivacaine hydrochloride injection 7.5 mg/mL for block of the brachial plexus via either the subclavian perivascular approach using 30 mL (225 mg) or via the axillary approach using 40 mL (300 mg) both provided effective and reliable anesthesia.
Plant tau glutathione S-transferase (GSTU) is a kind of multiple functions enzyme, but its specific roles in poplar disease resistance remain uncertain. In this study, 27 PdbGSTU-encoding genes from Populus davidiana × P. bollena were cloned and their protein architectures and phylogenetic relationships were subsequently analyzed. Expression analysis revealed that PdbGSTUs were differentially expressed under Alternaria alternate infection. Then, the PdbGSTU10 was further induced by phytohormones and H2O2, especially salicylic acid (SA), indicating its potential role in the pathogen defense of poplar. Subsequently, gain- and loss-of-function assays showed that overexpressed PdbGSTU10 activated antioxidant enzymes and significantly decreased reactive oxygen species (ROS) content, ultimately improving the resistance to A. alternate in poplar. Conversely, silencing PdbGSTU10 had the opposite effect. Moreover, overexpressed PdbGSTU10 also increased the content of SA and induced the expression of SA signal-related genes. These results showed that PdbGSTU10 may enhance disease resistance in poplar by scavenging ROS and affecting the SA signaling pathway. Our findings contribute to the understanding of the functions of GSTU in woody plants, particularly in disease resistance.
Providers will no longer be paid based upon FFS, but on the new payment model, which includes a PMPM payment for attributed members, a quality incentive payment based upon attainment of quality metrics, and a possible bonus payment for savings in total cost of care. Providers will also receive weekly emails that will show comparisons of their own performance against their peers within the same provider organization on specific quality measures and total cost of care. There is also a shared incentive between the member and the provider. The member incentive will be a payment made to diabetic patients with an A1C of greater than or equal to 9% who experience a reduction of at least 0.5%. Each participating member and PCP can receive up to $75 per quarter for A1C reduction.
Patients referred to the Fondazione Salvatore Maugeri for prolonged weaning are enrolled and trained in an individualised program of home care in order to recover their own autonomies. Home care compares 2 arms: usual care vs physiotherapist (PT)-assisted care. Usual care consists in supporting drug and oxygen therapy, mechanical ventilation, GP's assistance, periodical in-hospital visit. The PT-assisted home care is supported by PT at least 2 times/month, autonomous 50 min physical activity/working day by the help of a DVD. The physical activity consists in cyclette, calisthenic exercises, and training of the respiratory muscles. Few brief educational lessons by PT preceded the training activity. Every two weeks, PT calls the patient by phone for an educational reinforcement.
A method for lowering somatic cell count in the milk of a lactating ruminant is disclosed. IgY antibodies are first obtained from the egg of a hen which has been actively immunized against one or more mastitis-causing pathogenic organisms by injection with an immunogen containing immunogenic determinants specific to elicit such antibodies. The immunogenic determinant may comprise only a specific portion of the pathogenic organism, e.g., the fimbria of a piliated bacterium. The IgY antibodies are then administered orally to a ruminant in which it is desired to lower milk somatic cell count. Antibody administration may occur during a ruminant's dry period as well as during lactation. In a preferred embodiment, the antigen used in immunization of the hen comprises one or more of Staphylococcus aureus and Streptococcus agalactiae. The method of this invention has been shown to be efficacious in lowering somatic cell count in dairy cattle.
Trade in pangolins is illegal, and yet tons of their scales and products are seized at various ports. These large seizures are challenging to process and comprehensively genotype for upstream provenance tracing and species identification for prosecution. We implemented a scalable DNA barcoding pipeline in which rapid DNA extraction and MinION sequencing were used to genotype a substantial proportion of pangolin scales subsampled from 2 record shipments seized in Singapore in 2019 (37.5 t). We used reference sequences to match the scales to phylogeographical regions of origin. In total, we identified 2346 cytochrome b (cytb) barcodes of white-bellied (Phataginus tricuspis) (from 1091 scales), black-bellied (Phataginus tetradactyla) (227 scales), and giant (Smutsia gigantea) (1028 scales) pangolins. Haplotype diversity was higher for P. tricuspis scales (121 haplotypes, 66 novel) than that for P. tetradactyla (22 haplotypes, 15 novel) and S. gigantea (25 haplotypes, 21 novel) scales. Of the novel haplotypes, 74.2% were likely from western and west-central Africa, suggesting potential resurgence of poaching and newly exploited populations in these regions. Our results illustrate the utility of extensively subsampling large seizures and outline an efficient molecular approach for rapid genetic screening that should be accessible to most forensic laboratories and enforcement agencies.
The rotavirus nonstructural glycoprotein, NSP4, performs multiple functions in the virus replication cycle, especially during viral morphogenesis. Specifically, NSP4 is an intracellular receptor that mediates the acquisition of a transient membrane envelope during the budding of newly formed subviral particles into the endoplasmic reticulum (ER). We now report that NSP4 alone induces diarrhea in young (6-11 days) rodents (mice and rats) when administered by the intraperitoneal (IP) or intraileal (IL) route. A 22 amino acid synthetic peptide corresponding to NSP4 residues 114-135 (NSP4 114-135) also induces diarrheal disease. Disease induction by the protein or peptide is specific and is both age and dose-dependent, and it occurs in the absence of virus replication. No diarrhea was observed with control proteins or peptides administered to the same age animals and by the same route. Electrophysiologic data from intestinal mucosa indicate that NSP4 and the peptide stimulate a calcium-mediated rise in chloride secretion, i.e., potentiate chloride secretion by a calcium dependent signaling pathway. Based on these results, a new mechanism by which rotavirus induces diarrhea is proposed. This model involves two intestinal receptors. One receptor is needed to permit viral infection to be initiated, while a second age-dependent receptor is needed to interact with NSP4, a noncapsid viral protein, expressed and released from viral-infected cells. Induction of a signal transduction pathway following the interaction of NSP4 (a viral enterotoxin) with the second receptor leads to chloride secretion and diarrhea, i.e., diarrhea is induced when NSP4, acting as a viral enterotoxin, triggers a signal transduction pathway. The action of this viral enterotoxin with its specific receptor mimics that of bacterial enterotoxins.
This dual-site randomized clinical trial will use a "SMART" design to test a stepped care model relative to standard positive airway pressure (PAP) therapy and determine if (1) augmentation of PAP therapy with online Cognitive Behavioral Therapy improves short-term outcomes of comorbid obstructive sleep apnea(OSA)/insomnia; and (2) providing a higher intensity 2nd-stage cognitive behavioral therapy (CBT) to patients who show sub-optimal short-term outcomes with OCBT+PAP improves short and longer-term outcomes. After completing baseline assessment, the 384 comorbid OSA\\insomnia patients enrolled will be randomized to a 1st-stage therapy that includes usual care PAP + OCBT (n=288) or UC (usual care PAP + sleep hygiene education; n=96). Insomnia and OSA will be reassessed after 8 weeks. OCBT recipients who meet "remission" criteria will continue PAP but be offered no additional insomnia intervention and will complete study outcome measures again after an additional 8-weeks and at 3 and 6 month follow-ups. OCBT recipients classified as "unremitted" after 8 weeks of treatment will be re-randomized to a 2nd-stage treatment consisting of continued, expanded engagement in OCBT or a switch to therapist-directed CBT (TCBT). Those receiving the 2nd-stage intervention as well as the UC group will be reassessed after another 8 weeks and at 3- and 6-month follow-up time points.
OBJECTIVE: The objective of this study was to evaluate the prevalence of tethered cord among patients in the postoperative period of open and occult spina bifida. To identify warning signs for its early diagnosis, as well as outcomes after the new surgical approach.
METHODS: Retrospective study of patients followed at the Pediatric Neurosurgery Department of the Federal University of São Paulo with spinal dysraphism. Signs and symptoms indicating reoperation were collected, and postoperative results were classified as improved, unchanged, or worsened.
RESULTS: 222 medical records of patients diagnosed with spinal dysraphism were evaluated. Symptomatic Tethered Cord Syndrome (STCS) was identified in 30 patients (13.51%), with clinical manifestations related to orthopedic deformities (66.7%), neurological deficits (56.7%), urological dysfunction (50%), and intestinal dysfunction (40%). 20 cases underwent surgery for tethered cord release. The mean age at the time of surgery was 7.7 ± 4.9 years, with 13 female patients (65%). In the postoperative evaluation, improvement in low back pain (90.9%), urological pattern, and urinary tract infection episodes (45.4%) were particularly noteworthy. 3 patients (33.3%) with constipation showed improvement, and one worsened (11.1%). Improvement in ambulation was seen in two cases (16.7%). Low back pain was the first symptom to improve after surgery, with an average time of 1.3 months, followed by changes in the urological pattern at 15.6 months. Improvement in constipation was observed in the first month in 2 cases (66.7%), positive changes in ambulation were observed around 7 months after surgery, and only one case showed improvement in clubfoot correction.
CONCLUSIONS: The prevalence of tethered cord recurrence after primary correction surgery for open or occult neural tube closure defects was similar to that found in the literature. The results were encouraging, with good postoperative evolution of patients, especially in the improvement of low back pain and urological symptoms.
FIELD: organic chemistry, medicine. SUBSTANCE: invention describes novel compounds of the general formula (I)   where X is a member of corticosterone family of hormones and medicinal agents which is bound with Y through hydroxyl group; Y means linker residue taken among: a) dicarboxylic acid or anhydride; b) compound having carboxyl group and aldehyde; c) compound having carboxyl group and halide group; d) compound having carboxyl group and the group N=C=O; AA is amino acid; n = 0-5. B is H or CH 2 O-R 3 ; D is H or CH 2 O-R 1 ; F is R 2  or R 4, R 1, R 2, R 3  are similar or distinct and each means hydrogen atom, methyl, ethyl or fatty acid acyl group under condition that at least one of R 1, R 2, R 3  is the fatty acid acyl group; R 4  is fatty acid acyl group. New compounds of the formula (I) improve delivery, absorption, half-life value in body and targeting drugs in cell after their oral, intranasal and other routs of delivery. EFFECT: new compounds indicated above, improved properties. 34 cl, 16 tbl, 14 ex
OBJECTIVE: Scar tissue formation, as a normal part of wound healing, initiates in the proliferation phase, continues after the remodelling phase, and may cause an unpleasant appearance or disruption in normal functioning. This study investigated the effects of a topical gel on acute wound healing and reducing scars in a rat model.
METHOD: ChitoScar (ChitoTech Company, Iran), a commercial scar-reducing gel based on chitosan, was analysed for antibacterial and antiviral activity through a quantitative suspension test. Its cytotoxic effect was investigated, and then irritation and delayed-type hypersensitivity tests were carried out on rabbits through direct application of the gel. Furthermore, the effect of the chitosan-based gel on wound healing and scar tissue formation was studied in rats with an acute wound in two groups: the treatment group (topical application of the chitosan-based gel); and the control group (without treatment). Histopathological examination was carried out based on the inflammatory cells, collagen fibre, keratinocytes and fibroblasts.
RESULTS: Analysis revealed that the chitosan-based gel had no cytotoxicity and caused no erythema, oedema, local or other systemic adverse response. Wound healing occurred earlier in the treatment group, which was a result of a significant increase in re-epithelialisation, angiogenesis, fibroblast population and collagen fibre thickness (p<0.05). In the treatment group, wounds healed completely after 21 days and scars totally disappeared after 28 days, while in the control group, wound healing remained incomplete with distinct scar tissue.
CONCLUSION: The results demonstrated the positive effect of the chitosan-based gel on the duration and quality of the wound healing process, as well as minimising the scar tissue formation in this in vivo study.
The invention discloses a medicinal composition for treating a turtle cavity disease. The medicinal composition for treating the turtle cavity disease comprises the following Chinese herbs in parts by weight: 15-30 parts of hedyotis diffusa, 20-30 parts of groundsel, 5-15 parts of gallnut, 10-25 parts of golden cypress, 2-10 parts of wild chrysanthemum flower and 5-15 parts of onion. The invention further discloses a preparation of the medicinal composition. The hedyotis diffusa and the groundsel have a very strong anti-virus effect, so that the hedyotis diffusa and the groundsel as effective components can prevent and treat the turtle cavity disease better, with the cure rate as high as 99%. In the preparation method, the hedyotis diffusa is extracted with a supercritical carbon dioxide extraction method, so that effective components of the hedyotis diffusa, namely hentriacontane, stigmasterol, ursolic acid, oleanolic acid, beta-sitosterol, beta-sitosterol-D-glucoside and p-coumaric acid, have relatively high contents. The preparation method is simple and feasible and is applicable to large-scale production.
Spontaneous intracranial hypotension (SIH) typically presents as an acute orthostatic headache during an upright position, secondary to spinal cerebrospinal fluid leaks. New evidence indicates that a lumbar puncture may not be essential for diagnosing every patient with SIH. Spinal neuroimaging protocols used for diagnosing and localizing spinal cerebrospinal fluid leaks include brain/spinal MRI, computed tomography myelography, digital subtraction myelography, and radionuclide cisternography. Complications of SIH include subdural hematoma, cerebral venous thrombosis, and superficial siderosis. Treatment options encompass conservative management, epidural blood patches, and surgical interventions. The early application of epidural blood patches in all patients with SIH is suggested.
Subjects will take the assigned dose of I3C, Sil, or I3C + Sil once at the study center. Ten mL of blood will be collected at the time points described in Section 9.14. Concurrently, urine will also be collected for 24 hours after the first dose of I3C, Sil or I3C + Sil, divided into the time intervals.
PURPOSE: An information processing apparatus and an information processing method are provided to improve operational characteristics by automatically obtaining examination information based on a proper search condition after radiography. CONSTITUTION: A control unit (201) controls various operations of a photographic information processing device. An examination request information obtaining unit (202) obtains examination request information from a medial image management system based on the command of the control unit. An image obtaining unit (203) obtains image data based on the command of the control unit. An image storage unit (206) stores the obtained image data in a hard disk or a nonvolatile memory. An output control unit (205) controls the output of the image data. [Reference numerals] (200) Filming information input unit; (201) Control unit; (202) Examination request information obtaining unit; (203) Image obtaining unit; (204) Patient information modifying unit; (205) Output control unit; (206) Image storage unit