anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Liver fibrosis, a major global health issue, is marked by excessive collagen deposition that impairs liver function. Noninvasive methods for the direct visualization of collagen content are crucial for the early detection and monitoring of fibrosis progression. This study investigates the potential of spectral photoacoustic imaging (sPAI) to monitor collagen development in liver fibrosis. Utilizing a novel data-driven superpixel photoacoustic unmixing (SPAX) framework, we aimed to distinguish collagen presence and evaluate its correlation with fibrosis progression. We employed an established diethylnitrosamine (DEN) model in rats to study liver fibrosis over various time points. Our results revealed a significant correlation between increased collagen photoacoustic signal intensity and advanced fibrosis stages. Collagen abundance maps displayed dynamic changes throughout fibrosis progression. These findings underscore the potential of sPAI for the noninvasive monitoring of collagen dynamics and fibrosis severity assessment. This research advances the development of noninvasive diagnostic tools and personalized management strategies for liver fibrosis.
PURPOSE: To evaluate the 5-year changes in metamorphopsia and outer retinal morphology after vitrectomy for macula-off rhegmatogenous retinal detachment.
METHODS: The authors included 21 eyes from 21 patients with macula-off rhegmatogenous retinal detachment who underwent pars plana vitrectomy. Metamorphopsia was quantified using M-CHARTS. Using spectral-domain optical coherence tomography, the authors assessed the risk factors for metamorphopsia severity 5 years after surgery.
RESULTS: Metamorphopsia scores substantially improved from 1 month to 5 years postoperatively; however, they remained unchanged from 1 year to 5 years postoperatively. Overall, 11 patients (52.4%) had metamorphopsia 5 years postoperatively. The metamorphopsia scores in eyes with a continuous interdigitation zone and ellipsoid zone at 5 years were considerably lower than those in eyes with a disrupted interdigitation zone. Multiple regression analysis revealed that the metamorphopsia score at 5 years was markedly associated with the score at 1 month and continuous interdigitation zone.
CONCLUSION: No statistically significant change was observed in metamorphopsia scores after 1 year postoperatively, and >50% of the patients had metamorphopsia at 5 years postoperatively. The improvement was associated with lower metamorphopsia scores at 1 month and continuous interdigitation zone at 5 years. Moreover, the study revealed that early metamorphopsia was a poor prognostic marker for long-term functional deficits.
The invention discloses preparation methods of liquorice protein and nanoparticles of the liquorice protein. The liquorice protein with molecular weight of 31.0 kDa and isoelectric point of 4.5 is obtained through separation and purification. A primary structure sequence of N-end of the liquorice protein is NPDGLIACYCGQYCW. The liquorice protein nanoparticles are prepared by heating a saline solution of the liquorice protein at 100 DEG C under the conditions that the protein concentration is 1 mg/mL, and pH is 7.9 for 60 minutes, and the average particle size of the liquorice protein nanoparticles is 74.09+/-0.69 nm. Freeze-dried products of the liquorice protein nanoparticles are good in liquidity and re-solubility, and easy to stably store. The liquorice protein disclosed by the invention derives from food, and is high in safety. The preparation method of the liquorice protein nanoparticles does not involve any crosslinking agent, finished products of the liquorice protein nanoparticles widely exist in various decoction using liquorice, are taken by the majority of people for many years, and are high in safety. The liquorice protein nanoparticles disclosed by the invention are expected to be applied to in-vivo delivery of various medicines.
Participants will receive 10 sessions of cognitive training concurrent with transcranial direct current stimulation. Stimulation will be applied for 20 minutes at the beginning of each session. Current will be ramped from 0 mA to 2 mA over 30 seconds, and then ramped down from 2 mA to 0 mA at the end of 20 minutes. Current will be applied via two electrodes consisting of a pre-inserted carbon rubber snap electrode that is pre-saturated with saline and connects directly to designated electrode sites located on the tDCS headband. The anodal stimulating electrode will be at location F3 (based on the 10-20 EEG location system) and the cathodal electrode at location F4.
Cancer evolution lays the groundwork for predictive oncology. Testing evolutionary metrics requires quantitative measurements in controlled clinical trials. We mapped genomic intratumor heterogeneity in locally advanced prostate cancer using 642 samples from 114 individuals enrolled in clinical trials with a 12-year median follow-up. We concomitantly assessed morphological heterogeneity using deep learning in 1,923 histological sections from 250 individuals. Genetic and morphological (Gleason) diversity were independent predictors of recurrence (hazard ratio (HR) = 3.12 and 95% confidence interval (95% CI) = 1.34-7.3; HR = 2.24 and 95% CI = 1.28-3.92). Combined, they identified a group with half the median time to recurrence. Spatial segregation of clones was also an independent marker of recurrence (HR = 2.3 and 95% CI = 1.11-4.8). We identified copy number changes associated with Gleason grade and found that chromosome 6p loss correlated with reduced immune infiltration. Matched profiling of relapse, decades after diagnosis, confirmed that genomic instability is a driving force in prostate cancer progression. This study shows that combining genomics with artificial intelligence-aided histopathology leads to the identification of clinical biomarkers of evolution.
The present invention extends to methods, systems, and computer program products for collecting and transferring physiological data. Different physiological monitoring appliances can be attached to a portable physiological data collection device. Each physiological monitoring appliance can collect a different physiological data (blood glucose data, heart rate data, etc.) from an individual. Different physiological data can be collected and stored at the portable physiological data collection device. In response to a triggering event, a connection can be established to an external computer system. The stored physiological data can be transferred over the established connection to the external computer system. In some embodiments, the external computer system is a healthcare server that shares collected physiological data as well as other healthcare information with designated entities (e.g., family, doctors, etc.). The healthcare server can share healthcare information in accordance with patient configured rules so that patients have control over dissemination their healthcare information.
Telangiectasia-ectodermal dysplasia-brachydactyly-cardiac anomaly (TEBC) syndrome is a rare autosomal dominant condition, recently linked to the protein kinase D1 (PRKD1) gene. The phenotype of TEBC remains incomplete at this point. Our aim is to improve the characterization of the clinical and molecular aspects of the TEBC syndrome. We report on the 8th patient carrying a heterozygous de novo variation of PRKD1 c.2134G > A, p. (Val712Met) identified by trio exome sequencing. The proband presents with partial atrioventricular septal defect, brachydactyly, ectodermal dysplasia, telangiectasia that developed in childhood, intellectual disability with microcephaly, multicystic renal dysplasia and moderate hormonal resistance. In view of this 8th description and review of the literature, it appears that neurodevelopmental disorders and microcephaly are frequently associated with PRKD1 missense variants, adding to the four main clinical signs described initially in the TEBC syndrome. Further descriptions are required to confirm the observed endocrine and kidney abnormalities. This should contribute to a more comprehensive understanding of the phenotypic spectrum and may help establish genotype-phenotype correlations. In the context of genotype-first strategy, accurate patient descriptions are fundamental. Characterization of specific syndromic associations is essential for variant interpretation support and patient follow-up, even in very rare diseases, such as the TEBC syndrome.
Condition #1 will include 8 90-minute group sessions that will educate the subject about chronic pain, discuss the impact of pain, and inform the subject of different ways to manage it in hopes of decreasing pain and its impact on the subject's life. Participants in this condition will be given pre-recorded audio recordings of the content of the sessions to listen to.
Although research has illustrated that racial disparities in access to treatment for binge-eating disorder (BED) among Black women exist, little is known about the psychosocial related experiences of binge eating behaviors among Black women. Binge eating disorder is characterized by the recurrent consumption of large amounts of food within a brief period, accompanied by a loss of sense of control over the eating and distress over the eating behaviors. Past research has shown that race and gender related stressors are positively associated with emotional eating among Black young adult women and that they may engage in problem-solving coping strategies like identity shifting (conscious and unconscious alterations of thoughts, behaviors, perspective, and appearances) to manage these stressors. Considering the literature, the present study was developed to examine the mediating role of identity shifting in the relationship between gendered racism and binge eating symptoms among young adult Black women. To test this assertion, we administered an online survey to 239 Black women (Mage = 27.32). The results indicated that gender racism significantly predicted both identity shifting and binge eating and identity shifting significantly predicted binge eating. Additionally, identity shifting accounted for 34.5 % of the associations between gendered racism and binge eating symptoms. These findings highlight the importance of exploring experiences of discrimination and coping strategies when considering ways to reduce mental health concerns, such as binge eating symptoms, among young adult Black women.
Participants will receive treatment 1 in period 1 and treatment 2 in period 2. Where treatment 1= Empagliflozin Tablets 10 mg test product, treatment 2= Empagliflozin Tablets 10 mg reference product.
The clinical use of chemotherapy for refractory osteosarcoma (OS) is limited due to its multiorgan toxicity. To overcome this challenge, new dosage forms and combination treatments, such as phototherapy, are being explored to improve targeted delivery and cytocompatibility of chemotherapeutic agents. In addition, inducing ferroptosis in iron-rich tumors could be a promising strategy to enhance OS therapy. In this study, a novel formulation was developed using natural biological H-ferritin (HFn) encapsulating the photosensitizer IR-780 and the chemotherapy drug gemcitabine (Gem) for OS-specific targeted therapy (HFn@Gem/IR-780 NPs). HFn@Gem/IR-780 NPs were designed to specifically bind and internalize into OS cells by interacting with transferrin receptor 1 (TfR1) which is overexpressed on the surface of OS cell membranes. The Gem and IR-780 were then released responsively under mildly acidic conditions in tumors. HFn@Gem/IR-780 NPs achieved cascaded antitumor therapeutic efficacy through the combination of chemotherapy and phototherapy under near-infrared irradiation in vitro and in vivo. Importantly, HFn@Gem/IR-780 NPs demonstrated excellent safety profile with significantly decreased drug exposure to normal organs, indicating its potential for reducing systemic toxicity. Thus, utilizing HFn as a vehicle to encapsulate highly effective antitumor drugs provides a promising approach for the treatment of OS metastasis and relapse.
Use of a LAG-3 protein or derivative thereof as part of a combination therapy for the treatment of cancer is described. In particular. (a) a LAG-3 protein, or a derivative thereof that is able to bind to MIC class II molecules. (b) a programmed cell death protein-1 (PD-1) pathway inhibitor, and (c) a chemotherapy agent, for use in preventing, treating, or ameliorating a cancer in a subject is described. Combined preparations, and pharmaceutical compositions, comprising: (a) a LAG-3 protein, or derivative thereof that is able to bind to MHC class II molecules: (b) a programmed cell death protein-1 (PD-1) pathway inhibitor; and (c) a chemotherapy agent, are also described. Use of the combined preparations and compositions as medicaments, in particular for the prevention, treatment, or amelioration of cancer are also described, as are methods for the prevention, treatment, or amelioration of cancer.
<P>PROBLEM TO BE SOLVED: To provide a gene-modified animal in which the expression of a LOX-1 gene pair is inactivated, capable of being used for elucidating physiological activities of the LOX-1 in an individual body level and enabling the utilization of the same for a research on a therapeutic agent, etc., of diseases including arteriosclelosis, etc., associated with the gene.  <P>SOLUTION: This LOX-1 defective mouse is produced by a gene-targeting method. By an analysis using the produced LOX-1 gene defective mouse, it becomes clear that a LOX-1 antagonist is useful for improving a morbid state caused by the lowering of endothelial function. Also, it becomes clear that the LOX-1 is associated with an infection with a protozoan. Thus, the LOX-1 gene defective animal is a useful model for elucidating a new function of the LOX-1. The knock out mouse of the function of the LOX-1 gene becomes a useful model mouse for exploring the unknown role of the LOX-1 gene in the onset and development of the arteriosclerosis, etc.  <P>COPYRIGHT: (C)2004,JPO&NCIPI
Infants enrolled will be exposed to maternal voice for 20 min immediately prior to being offered oral feedings. This exposure will be conducted 2 times a day until infant starts taking all enteral feeds orally.
Carbapenems are considered the antibiotics of choice for the treatment of infections due to expanded-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-PE). Their use is readily increasing because of the pandemic of ESBL-PE. However, the future of these drugs is challenged by the worldwide emergency of new resistance mechanisms in the same pathogens, particularly the carbapenemases. This resistance makes these drugs inactive and gives no therapeutic options for patients. Resistance to carbapenems is strongly associated with the use of these drugs, because of their large spectrum and strong impact on the host flora. Consequently, the correct use of these drugs is an important public health objective. In France, the CA-SFM (Committee on Antimicrobial of the French Society for Microbiology) has suggested alternative strategies with narrow spectrum beta-lactam for the treatment of ESBL-PE infections, including 3rd or 4th cephalosporins, cefoxitin and penicillins with beta-lactamase inhibitors. A recent analysis including 6 prospective cohort studies of bloodstream infections due to ESBL-producing Escherichia coli did not find an excess of mortality or a longer length of hospital stay for patients receiving penicillin with beta-lactamase inhibitors, as compared to patients treated with carbapenems, after adjusting by confounding factors. As patients receiving carbapenems seem to be more severely affected, the efficacy and safety of the alternative strategy remain unproved. A randomized study is therefore needed to evaluate a deescalating therapeutic strategy (switch the carbapenem to another beta-lactam for which the isolated pathogen is susceptible) in patients with well-defined ESBL-PE infections (usual sites of infections and non severe infections). The objectives of the present study are to demonstrate that the alternative strategy of deescalating therapy is not inferior to a strategy maintaining the carbapenem in terms of clinical cure, survival, lack of relapse and microbiological cure.
Graft rejection and graft versus host disease after HLA-identical stem cell transplantation is the result of recognition of minor histocompatibility antigens on donor stem cells by immunocompetent T lymphocytes from recipient origin. T lymphocyte clones specifically recognizing H-Y epitopes on male target cells have been generated during graft-rejection after sex-mismatched transplantation. Previously, two human H-Y epitopes derived from the same SMCY gene have been identified that were involved in bone marrow graft rejection. Here, we report the identification of a new male-specific transplantation antigen encoded by the Y-chromosome-specific gene DFFRY. The DFFRY-derived peptide was recognized by an HLA-A1 restricted CTL clone, which was generated during graft rejection from a female patient with acute myeloid leukemia who rejected her HLA-phenotypically identical bone marrow from her father. The identification of this gene demonstrates that at least two genes present on the human y-chromosome code for male-specific transplantation antigens.
Topographical disorientation is linked to lesions in the right hemisphere and typically resolves within a few months post-stroke. Persistent topographical disorientation is uncommon and frequently accompanied by impairments in visual memory, complicating the analysis of the underlying mechanisms. Herein, we report two cases of sustained pure topographical disorientation following cerebral hemorrhages in the left retrosplenial region. The patients exhibited disorientation in both familiar and unfamiliar settings, attributable to heading disorientation, a deficit in determining the directional relationship between one's current position and a target location or external frames. The patients struggled with reconstructing large-scale spatial frameworks and integrating new egocentric and allocentric perspectives upon changes in body orientation. There were no landmark agnosia, egocentric disorientation, or anterograde disorientation. Although mild verbal memory deficits were observed, no other cognitive impairments, including visual memory deficits, were detected. Our findings imply that lesions confined to the left retrosplenial region can induce enduring heading disorientation and suggest a significant role for this area in processing and integrating spatial information necessary for large-scale navigation. Clarifying the features of topographical disorientation will significantly impact the therapeutic approaches, enhancing the quality of life for affected patients by restoring their independence and mobility.
PURPOSE: To obtain a gelled, moist and smooth cosmetic, excellent in gelation performances and good in feeling of use and touch after drying by converting a polyacidic amino acid as a humectant agent into a gel with a certain peptide derivative and an inorganic salt. CONSTITUTION: This gelled cosmetic is produced by using (A) a polyacidic amino acid or its salt, (B) a peptide derivative of the formula [R<1> is a 4-22C alkyl or alkenyl; X is CH2 , COO or CONH; Y is a peptide residue; Z is a halogen; (n) is 0-4] and (C) an inorganic salt in combination. A sugar or a sugar derivative may further be added to this system. The polyacidic amino acid is preferably polyglutamic acid or polyaspartic acid. The molecular weight and blending amount thereof are preferably 1,000-10,000 and about 0.05-10wt.%, respectively. The peptide derivative of the formula includes hydrolyzed peptides converted into higher alkyl or alkenyl quaternary ammoniums, etc., and the blending amount thereof is about 0.05-10wt.%. The inorganic salt includes sodium chloride, etc., and the blending amount thereof is about 0.01-7wt.%.
0004159.315074 (SA5074 CA DIV) SYSTEMS, COMPUTER MEDIUM AND COMPUTER-IMPLEMENTED METHODS FOR MONITORING HEALTH OF EMPLOYEES USING MOBILE DEVICES ABSTRACT Provided are embodiments of systems, computer medium and computer-implemented methods for monitoring the health of an employee. The method including collecting health data from a set of one or more health sensors provided on or near the employee while the employee is engaged in their work duties. The one or more health sensors configured to output health data corresponding to characteristics sensed by the sensor, the one or more health sensors comprising at least one or more biometric and biomechanic sensors configured to sense biometric and biomechanic characteristics of the employee with at least one of the one or more health sensors integrated within a mobile communications device. The health data collected being used to determine a health profile for the employee. The method including displaying, via the mobile communications device, a health report that includes the health profile for the employee. Date Recue/Date Received 2020-08-24
<P>PROBLEM TO BE SOLVED: To provide a hair dye which mainly comprises a plant and a plant- derived component, can dye by a simple operation, has high dyeing capability and safeness, and hardly emits a metallic odor peculiar to an iron salt.  <P>SOLUTION: This hair dye contains at least one iron salt, at least one organic compound which develops color by the reaction with the iron salt, at least one plant extract which develops color by the reaction with the iron salt, and at least one kind of tea carbonization liquid/cnidium rhizome extract. The plant and the plant-derived component are the main ingredients. The hair-dyeing operation with the hair dye is simple. The hair dye is excellent in dyeing properties and safeness and hardly emits a metallic odor peculiar to an iron salt.  <P>COPYRIGHT: (C)2003,JPO