anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: The treatment of recurrent thyroid cancer with critical organ invasion is challenging. The combination of radiofrequency ablation (RFA) and external beam radiation therapy (EBRT) has been proposed as an effective option. This study evaluates outcomes for inoperable residual/recurrent differentiated thyroid cancer (rDTC) patients treated with RFA followed by EBRT.
MATERIALS AND METHODS: Patients with rDTC treated with RFA followed by EBRT were retrospectively studied. RFA was performed using a free-hand, 'moving-shot' technique under US or CT guidance. For lesions invading critical structures intolerant to 'en bloc' high-temperature RFA, limited-field EBRT using 6- or 10-MV photons was used for adjuvant treatment at a dose of 66 Gy in 33 daily fractions. Toxicities and outcomes were reviewed.
RESULTS: Between April 2020 and January 2022, 11 patients with 14 rDTC lesions underwent RFA followed by EBRT. Five patients had metastatic lesions at rDTC diagnosis. With a median follow-up period of 33.7 months, all patients maintained locoregional control, while achieving a 2-year survival rate of 90.9%. This combined treatment achieved a volume reduction ratio of 92.1% ± 5.1%. The mean nadir thyroglobulin level in patients without initial distant metastases after treatment was 1.40 ± 0.81 ng/ml. Regarding treatment-related complications, one patient (9%) experienced temporary hoarseness after RFA, grade 2 radiation dermatitis occurred in 3 patients (27.2%), and grade 2 dysphagia was noted in 4 patients (36.4%). No grade 3 or greater toxicities occurred.
CONCLUSIONS: Salvage RFA followed by EBRT is feasible, effective and safe for patients with rDTC.
The invention discloses an alpha-gel emulsifier combination capable of being applied to preparing face cream and application thereof. The polyglycerol fatty acid ester which is screened and compounded and has high temperature property is used as an emulsifier, and an emulsifier combination which can be applied to the face cream to form alpha-gel is preferably selected. The alpha-gel emulsifier combination consists of polyglycerol-3 stearate and polyglycerol-10 dipalmitate according to the mass ratio of 1:2.4 to 1:2.6, and the components are matched in the range of the mass ratio. At the same time, the combination can be used to prepare creams (or cream bases) containing an alpha-gel lamellar structure. The alpha-gel emulsifier combination has excellent mildness and stable self-thickening property, and can assist in improving skin barrier function and balancing facial grease secretion. The invention can provide reference for further expanding the application of the alpha-gel emulsifier combination in the industry, and better meets the urgent need of the personal care consumer market for the diversification of the face cream.
A second randomization step occurs at 6-months. Participants randomized to this condition receive clinical pharmacist, CHW, and CGM support.
Longitudinal follow-up cohort in which all patients who are going to receive a kidney transplant and meet the selection criteria for this study cohort will be included. This cohort will be recruited at sites that routinely perform Protocol Biopsies (PB) one year after transplant. A pre-transplant and post-transplant follow-up IMBG at 3, 6, 9 and 12 months will be performed, and additional IMBG will be carried out when an indication biopsy is required due to a suspected rejection during the patients' follow-up. A protocol biopsy will be performed after one year of follow-up of the patients.
The present invention relates to a novel nickel composite and derivatives thereof for simulating the active site of a nickel-containing superoxide dismutase (NiSOD). 5-coordination Ni (II) and Ni (III) composites or derivatives thereof and 6-coordination derivatives have a structure represented by a chemical formula (I) and a chemical formula (II). The nickel composites and their derivatives of the present invention act as antioxidants or free radical removers. The nickel composites of the present invention can be used in environment or soil protection. The nickel composites of the present invention can be applied to, drugs, health foods or cosmetics for a human, an animal and a plant. [Reference numerals] (AA) g value
The study will be conducted in the clinic of Conservative Dentistry Department, Faculty of Dentistry, Cairo University; the operator in charge samah mohamed bahig, The subjects fulfilling the eligibility criteria of the trial will be selected from the regular attendees at the clinic of Conservative Dentistry Department, Faculty of Dentistry, Cairo University. Patient examination will be done including medical history, dental history, extra-oral examination and intraoral examination. A periapical radiograph will be taken prior to restorative procedures to assess the degree of approximation of caries to pulp, intactness of lamina dura and/or presence of any periapical radiolucency to exclude the case. The field of operation will be isolated with the application of a rubber dam if possible. Otherwise, cotton rolls and the saliva ejector will be used for moisture control. For cavity preparation, local anesthetic (MepecaineL, Alexandria Company, Egypt) solution will be administrated to control patient discomfort during the procedure. The cavities will be prepared by using cylindrical #314 (Komet®, Germany) in a high speed handpiece (Sirona, Germany) rotating at high speed with copious coolant. Remaining soft caries

-if present- will be removed using sharp excavator (Maillefer, Dentsuply, Switzerland).After the cavity preparation is finished, it will be thoroughly air-water cleaned. The bonding system; the Prime and Bond universal adhesive (Dentsply De Trey GmbH, Konstanz, Germany) will be applied according to the following instructions recommended by the manufacturer and rubbed for 20 seconds then blown with a gentle air blow for 5 seconds to evaporate the solvent and then light curing for 10 seconds using LED light curing unit (\>700 mW/cm2).The prepared cavities will be restored with Zenit Nano Ceramic Composite (PRESIDENT DENTAL, GmbH, Munich, Germany) will be applied with incremental placement technique (maximum: 2-mm layer). Increments will be light curing for 40 seconds according to manufacturer's instructions. and for the control group cavities will be restored withCeram•X (Dentsply De Trey GmbH, Konstanz, Germany) with incremental placement technique (maximum: 2-mm layer). Increments will be light cured for 20 seconds according to manufacturer's instructions.
Patients receive pemetrexed disodium IV over 10 minutes and cisplatin IV over 2 hours on day 1 and cediranib maleate PO QD on days 1-21. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then receive cediranib maleate alone PO QD in the absence of disease progression or unacceptable toxicity.
Methods, apparatuses, systems, and implementations for creating a patient-specific soft bolus for radiotherapy treatment are disclosed. 2D and/or 3D images of a desired radiotherapy treatment site may be acquired, such as the head, neck, skin, breast, anus, and/or vulva. A user may interact with one or more representations of the images via an interactive user interface such as a graphical user interface (GUI). The images may include target/avoidance structures and radiation beam arrangement. The user may interact with the images to create a visualization of a patient-specific bolus. The visualization and properties of the bolus may be modified as the user manipulates aspects of the image. Data corresponding to the bolus models may be used to create 3D printed negative molds of the bolus model using 3D printing technology. A soft patient-specific bolus may be cast using the 3D printed model.
PURPOSE:To provide the subject lightweight impression base excellent in acclimatizability, improved in mechanical strength by simply conducting ion plating treatment to provide the material surface with a TiN coating layer following being formed into denture base. CONSTITUTION:A Ti-based superplastic allay plate 1 is put on a model 2 prepared in advance, and the space for both the plate 1 and model 2 is vacuumed from the side of the model 2 under pressurization with an inert gas like argon at the temperature giving superplastic deformation of said alloy plate 1 (about 900 deg.C) in a nonoxidative atmosphere, thus impressing the shape of the model 2 onto the alloy plate 1 (press impression). Subsequently, after releasing, the surface of the alloy plate formed is cleaned by e.g. buff abrasion and then put to ion plating treatment; thereby affording the objective impression base 7 with its surface provided with a TiN coating layer. Because the impression base 7 can be made into adequately thin-walled one, fine design can also be impressed accurately. This impression base 7, which is light in weight and has high mechanical strength, is also excellent in acclimatizability with resin for dentine fixation.
BACKGROUND: Endometriosis is one of the most common benign gynecological diseases and is characterized by chronic pain and infertility. Endoplasmic reticulum (ER) stress is a cellular adaptive response that plays a pivotal role in many cellular processes, including malignant transformation. However, whether ER stress is involved in endometriosis remains largely unknown. Here, we aimed to explore the potential role of ER stress in endometriosis, as well as its diagnostic value.
METHODS: We retrieved data from the Gene Expression Omnibus (GEO) database. Data from the GSE7305 and GSE23339 datasets were integrated into a merged dataset as the training cohort. Differentially expressed ER stress-related genes (DEG-ERs) were identified by integrating ER stress-related gene profiles downloaded from the GeneCards database with differentially expressed genes (DEGs) in the training cohort. Next, an ER stress-related gene signature was identified using LASSO regression analysis. The receiver operating characteristic curve was used to evaluate the discriminatory ability of the constructed model, which was further validated in the GSE51981 and GSE105764 datasets. Online databases were used to explore the possible regulatory mechanisms of the genes in the signature. Meanwhile, the CIBERSORT algorithm and Pearson correlation test were applied to analyze the association between the gene signature and immune infiltration. Finally, expression levels of the signature genes were further detected in clinical specimens using qRT-PCR and validated in the Turku endometriosis database.
RESULTS: In total, 48 DEG-ERs were identified in the training cohort. Based on LASSO regression analysis, an eight-gene-based ER stress-related gene signature was constructed. This signature exhibited excellent diagnostic value in predicting endometriosis. Further analysis indicated that this signature was associated with a compromised ER stress state. In total, 12 miRNAs and 23 lncRNAs were identified that potentially regulate the expression of ESR1, PTGIS, HMOX1, and RSAD2. In addition, the ER stress-related gene signature indicated an immunosuppressive state in endometriosis. Finally, all eight genes showed consistent expression trends in both clinical samples and the Turku database compared with the training dataset.
CONCLUSIONS: Our work not only provides new insights into the impact of ER stress in endometriosis but also provides a novel biomarker with high clinical value.
Participants will be placed on this arm for a total of 14+- 4 days from visit 2. Participants will be using the Toffee mask during this treatment arm.
ETHNOPHARMACOLOGICAL RELEVANCE: 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside (TSG) as the primary constituent of Polygonum multiflorum Thumb. (PM) possesses anti-oxidative, antihypercholesterolemic, anti-tumor and many more biological activities. The root of PM has been used as a tonic medicine for thousands of years. However, cases of PM-induced liver injury are occasionally reported, and considered to be related to the host immune status.
AIM OF THE STUDY: The primary toxic elements and specific mechanisms PM causing liver damage are still not thoroughly clear. Our study aimed to investigate the influences of TSG on the immune response in idiosyncratic hepatotoxicity of PM.
MATERIALS AND METHODS: The male C57BL/6 mice were treated with different doses of TSG and the alterations in liver histology, serum liver enzyme levels, proportions of T cells and cytokines secretion were evaluated by hematoxylin and eosin (HE), RNA sequencing, quantitative real time polymerase chain reaction (qRT-PCR), Flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA), respectively. Then, primary spleen cells from drug-naive mice were isolated and cultured with TSG in vitro. T cell subsets proliferation and cytokines secretion after treated with TSG were assessed by CCK8, FCM and ELISA. In addition, mice were pre-treated with anti-CD25 for depleting regulatory T cells (Tregs), and then administered with TSG. Liver functions and immunological alterations were analyzed to evaluate liver injury.
RESULTS: Data showed that TSG induced liver damage, and immune cells infiltration in the liver tissues. FCM results showed that TSG could activate CD4+T and CD8+T in the liver. Results further confirmed that TSG notably up-regulated the levels of inflammatory cytokines including TNF-α, IFN-γ, IL-18, perforin and granzyme B in the liver tissues. Furthermore, based on transcriptomics profiles, some immune system-related pathways including leukocyte activation involved in inflammatory response, leukocyte cell-cell adhesion, regulation of interleukin-1 beta production, mononuclear cell migration, antigen processing and presentation were altered in TSG treated mice. CD8+T/CD4+T cells were also stimulated by TSG in vitro. Interestingly, increased proportion of Tregs was observed after TSG treatment in vitro and in vivo. Foxp3 and TGF-β1 mRNA expressions were up-regulated in the liver tissues. Depletion of Tregs moderately enhanced TSG induced the secretion of inflammatory cytokines in serum.
CONCLUSIONS: Our findings showed that TSG could trigger CD4+T and CD8+T cells proliferation, promote cytokines secretion, which revealed that adaptive immune response associated with the mild liver injury cause by TSG administration. Regulatory T cells (Tregs) mainly sustain immunological tolerance, and in this study, the progression of TSG induced liver injury was limited by Tregs. The results of our investigations allow us to preliminarily understand the mechanisms of PM related idiosyncratic hepatotoxicity.
Alzheimer's disease (AD) is the most common neurodegenerative disease that is responsible for about one-third of dementia cases worldwide. It is believed that AD is initiated with the deposition of Ab plaques in the brain. Genetic studies have shown that a high number of AD risk genes are expressed by microglia, the resident macrophages of brain. Common mode of action by microglia cells is neuroinflammation and phagocytosis. Moreover, it has been discovered that inflammatory marker levels are increased in AD patients. Recent studies advocate that neuroinflammation plays a major role in AD progression. Microglia have different activation profiles depending on the region of brain and stimuli. In different activation, profile microglia can generate either pro-inflammatory or anti-inflammatory responses. Microglia defend brain cells from pathogens and respond to injuries; also, microglia can lead to neuronal death along the way. In this review, we will bring the different roles played by microglia and microglia-related genes in the progression of AD.
Systems, methods, and apparatuses for a safe delivery system for a modified atmosphere and functional treatments into a sealed enclosure containing perishable products. The systems, methods, and apparatuses may include an injector, a top sheet dispenser, a bottom sheet dispenser, and pallet wrapper. The top sheet, bottom sheet, and wrap sheet form the sealed enclosure. The injector may create a modified atmosphere in the sealed enclosure. The injector may include a stabilizing support bar and at least one nozzle formed at a right angle to the stabilizing support bar. The nozzle may be connected to a gas source for injecting at least one gas into the sealed enclosure. The nozzle may be connected to a vacuum or controlled venting source to remove air and control the pressure within the sealed enclosure. The injection process is protected from leakage using containment devices, pads and/or aspirating covers or a closed chamber. The system includes the use of modified atmosphere and various functional substances to sanitize, condition, protect, preserve, or enhance perishable products.
A vaccine comprises the Komarov KH strain of Newcastle disease virus cultivated on mammalian kidney tissue culture of one mammalian species, e.g. calf or more than one mammelian species, e.g. calf and pig.  In general, more than one serial passage is used, e.g. 21 passages through calf kidney culture or 10 serial passages on calf kidney tissue culture followed by 11 serial passages on pig kidney tissue culture.  Pieces of kidney are treated with a buffered saline solution of trypsin.  The freed cells are suspended in Hank's solution, centrifuged and incubated in a nutrient medium comprising lactalbumin hydrolyate, yeast extract, calf serum, sodium penicillin and streptomycin sulphate in Hank's solution, at 37 DEG  C. for 3 days, fresh nutrient medium added and incubation continued until a complete mono-layer developes.  This is inoculated with KH strain of Newcastle disease virus in thick embryo allantoic fluid and diluted 1/100 with above nutrient fluid and incubated for three days at 37 DEG  C.  The culture is then frozen, thawed, shaken and centrifuged. The supernatant is inoculated into another kidney kidney tissue culture and the process repeated for the desired number of serial passages.  The resultant culture fluid may be formulated into a vaccine.
Hypersensitivity reactions have been reported in association with KEVZARA [see Adverse Reactions (6.1)]. Hypersensitivity reactions that required treatment discontinuation were reported in 0.3% of patients in controlled RA trials. Injection site rash, rash, and urticaria were the most frequent hypersensitivity reactions. Advise patients to seek immediate medical attention if they experience any symptoms of a hypersensitivity reaction. If anaphylaxis or other hypersensitivity reaction occurs, stop administration of KEVZARA immediately. Do not administer KEVZARA to patients with known hypersensitivity to sarilumab [see Contraindications (4) and Adverse Reactions (6.1)].
NEW MATERIAL:A norbornene derivative of formula I (R1 is vinyl, ethylidene or ethyl; R2 and R3 are hydroxyl, alkoxy, hydroxymethyl, alkoxymethyl, acyl, etc.; one of R2 and R3 is H or alkyl; the group of formula II is single or double bond). EXAMPLE:6-Vinyl-2-norbornylmethylidenemalonic acid diethyl ester. USE:Useful as a perfume, plasticizer, crosslinking agent, reactive diluent, biochemical drug, etc. Also useful as a basic raw material for the synthesis of other norbornene compounds. PREPARATION:The compound of formula III (R4 is H, alkyl or acyl) which is one of the compound of formula I can be produced e.g. according to the reaction formula by Wittig reaction using LiAlH4, etc.
Patients receive Abraxane IV over 30 minutes on days 1, 8, and 15 and apply topical imiquimod to cutaneous lesions QD on days 1-4, 8-11, 15-18, and 22-25. Treatment repeats every 28 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity.
Breastfeeding is the healthiest and most effective way for the unique nutrient breast milk to reach the baby. Breastfeeding has many physiological, psychological, social, emotional, societal and economic benefits. Women's inexperience in breastfeeding, the weak value they attribute to breastfeeding, lack of social support systems, and breastfeeding problems they experience can be obstacles to successful breastfeeding. Breastfeeding problems experienced during the lactation process lead to a feeling of exhaustion and inadequacy in the mother and cause mothers to stop breastfeeding. The most common factors that negatively affect breastfeeding are; nipple trauma, breast pain, breast fullness, mastitis, excessive or low breast milk production, difficulty in placing the baby at the breast, breast refusal in the baby, the mother and/or the baby being sick and using medication as a result, fatigue and exhaustion in the mother. Along with these problems, the mother's return to work life is also among the factors that negatively affect breastfeeding. Breastfeeding education and counseling programs are effective in initiating and continuing breastfeeding, solving breastfeeding problems, increasing self-sufficiency, and increasing breastfeeding rates. Nurses, who are important building blocks of the health team, provide support to mothers from the prenatal period to the postnatal period by using their roles as caregivers, decision-makers, patient rights advocates, educators, and consultants. Today, thanks to the development of technology and easy access, traditionally applied trainings have been replaced by trainings provided with newer, modern, visual technologies. These can be listed as peer education, telephone counseling, online and web-based counseling, teach-back, home visits, and model use. Studies have reported that health education programs based on the Information-Motivation-Behavioral Skills Model have a positive effect on individuals' health practices, increase self-sufficiency, and contribute to the development of positive behaviors in individuals. In recent years, motivational interviewing techniques have also been frequently encountered in nursing practices. With the motivational interviewing technique applied during the breastfeeding process, mothers' individual preferences are valued, their indecisiveness is resolved, and their self-sufficiency is supported. In this context, this study aimed to examine the effect of motivational interviews based on the Knowledge, Motivation, Behavioral Skills Model on breastfeeding. The randomized controlled experimental study will be conducted with 90 people (45 experimental, 45 control group) who meet the sampling criteria between October 30, 2024 and July 30, 2025. 4 sessions of motivational interviewing will be applied to the experimental group, and no intervention will be made to the control group. The analysis of the collected data will be done with the SPSS program.
BACKGROUND: Absent or hypoplastic nasal bone (AHNB) on first or second-trimester ultrasonography (USG) is an important soft marker of Down syndrome. However, due to its varied incidence in euploid and aneuploid fetuses, there is always a dilemma of whether to go for invasive fetal testing for isolated AHNB. This study aims to assess outcomes specifically within the context of Indian ethnicity women.
MATERIALS AND METHODS: This was a prospective observational study. All patients who reported with AHNB in the first- or second-trimester USG were included. Genetic counseling was done, and noninvasive and invasive testing was offered. Chromosomal anomalies were meticulously recorded, and pregnancy was monitored.
RESULTS: The incidence of AHNB in our study was 1.16% (47/4051). Out of 47 women with AHNB, the isolated condition was seen in 32 (0.78%) cases, while AHNB with structural anomalies was seen in nine cases (0.22%). Thirty-nine women opted for invasive testing. Six out of 47 had aneuploidy (12.7%), while two euploid cases (4.25%) developed nonimmune hydrops. The prevalence of Down syndrome in fetuses with AHNB was 8.5% (4/47) and 0.42% (17/4004) in fetuses with nasal bone present. This difference was statistically significant (p = .001).
CONCLUSION: The results indicate that isolated AHNB cases should be followed by a comprehensive anomaly scan rather than immediately recommending invasive testing. However, invasive testing is required when AHNB is associated with other soft markers or abnormalities. As chromosomal microarray is more sensitive than standard karyotype in detecting chromosomal aberrations, it should be chosen over karyotype.