anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide a clinical data collection system which is highly convenient for three parties; a business which wishes collection of clinical data, and a clinical medicine researcher; a physician who pursues clinical researches; and a patient who participates in the clinical researches.  <P>SOLUTION: A clinical researcher computer 100 which accumulates explanatory material for patients to be used for informed consent at the time of clinical research is established accessibly from a physician's computer 300 via a network 200. The clinical researcher computer 100 transmits accumulated explanatory material for patients to the physician's computer 300 based on agreement to conditions to promote registration of the clinical data. When the patient approves participation to the clinical research, the physician inputs clinical data as a result into the physician's computer 300. The inputted clinical data is transmitted to the clinical researcher computer 100 and registered to a clinical data DB 160.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The present invention discloses a traditional Chinese medicine for treating coronary disease. The traditional Chinese medicine is composed of 1 portion of panax notoginseng, 1 portion of leech and 1 portion of cliff starwort herb by weight. Through the combination of the panax notoginseng, the leech and the cliff starwort, the blood flow of coronary artery can be enhanced obviously, and the myocardial oxygen consumption is reduced. Moreover, the traditional Chinese medicine has the functions of reducing the arterial pressure and the heart rate, so the workload of the heart is reduced. The traditional Chinese medicine mainly uses the etiology and the pathogenesis of western medicines as a guiding theory, and is prepared from traditional Chinese herbs with no side effect. The traditional Chinese medicine is convenient to take and has a lasting therapeutic effect. By the traditional Chinese medicine, the illness states of patients can be kept stable, or the patients can be safe without disease paroxysm. The cure rate of the traditional Chinese medicine is over 90% by multiple years of clinical verification.
PURPOSE:To enable early execution of quick and simple diagnosis of adult periodontitis by combining separation of a ciliary antigen of Bacteroides- gingivalis (B-g) with a latex agglutination reaction using B-g ciliary antibody- sensitized latex. CONSTITUTION:The title reagent is formed of latex particles prepared by making an antibody to a ciliary antigen of B-g sensitize the same. The latex particle needs only to be a latex particle which is ordinarily used as a reagent for detection using the antibody. Besides, a cilium obtained by preparation of the ciliary antigen is used as an antigen. The ciliary antigen of B-g thus obtained is given to an animal for immunization. In order to execute sensitization of the latex particle by an antiserum or a monoclonal antibody to the B-g ciliary antigen, subsequently, a physical adsorption method or a chemical combination method is adopted. Then, a subject of a man who is expected to be infected with periodontitis is brought into contact with the reagent for detection formed of the latex particles prepared by making the antibody sensitize the same. This subject is treated by a treating agent which causes no loss of antigenicity of the cilium of the B-g.
A system and method for providing compliance predictions for using a respiratory pressure therapy device in a treatment regimen is disclosed. The system includes a respiratory pressure therapy device having a transmitter and an air control device to provide respiratory therapy to a patient. The respiratory pressure therapy device collects operational data and transmits the collected operational data. Demographic data of the patient is collected. A predicted compliance with the treatment regimen is determined based on inputting operational data and demographic data to a machine learning compliance prediction model having a compliance prediction output. The machine learning model is trained from the operational data and demographic data of a population of patients using respiratory pressure therapy devices.
BACKGROUND: Sepsis is associated with about 20% of deaths worldwide. It often presents with non-specific initial symptoms, making its emergency treatment an interdisciplinary and cross-sectoral challenge. Three in four sepsis survivors suffers from new cognitive, psychological, or physical sequelae for which specific treatment concepts are scarce. The AVENIR project aims to improve the understanding of patient pathways, and subjective care experiences and needs along the entire healthcare pathway before, with and after sepsis. Based on this, concrete recommendations for the organization of care and patient information materials will be developed with close patient participation.
METHODS: Mixed-methods study including (1) analysis of anonymized nationwide health claims data from Germany, (2) linkage of health claims data with patient care reports (PCR) of emergency medical services from study regions in two federal states within Germany, and (3) qualitative exploration of the patient, relative, and care provider perspective on sepsis care. In (1), we analyze inpatient and outpatient health care utilization until 30 days pre-sepsis; clinical sepsis care including intra- and inter-hospital transfers; and rehabilitation, inpatient and outpatient aftercare of sepsis survivors as well as costs for health care utilization until 24 months post-sepsis. We attempt to identify survivor classes with similar health care utilization by Latent Class Analyses. In (2), PCR are linked with health claims data to establish a comprehensive database outlining care pathways for sepsis patients from pre-hospital to follow-up. We investigate e.g., whether correct initial assessment is associated with acute (e.g., same-day lethality) and long-term (e.g., new need for care, long-term mortality) outcomes of patients. We compare the performance of sepsis-specific screening tools such as qSOFA, NEWS-2 or PRESEP in the pre-clinical setting. In (3), semi-structured interviews as well as synchronous and asynchronous online focus groups are conducted and analyzed using qualitative content analyses techniques.
DISCUSSION: The results of the AVENIR study will contribute to a deeper understanding of sepsis care pathways in Germany. They may serve as a base for improvements and innovations in sepsis care, that in the long-term can contribute to reduce the personal, medical, and societal burden of sepsis and its sepsis sequelae.
TRIAL REGISTRATION: Registered at German Clinical Trial Register (ID: DRKS00031302, date of registration: 5th May 2023).
A combination of a nucleic acid and an electric field with an intensity of 1-800 V/cm for simultaneous, separate or sequential administration to a tissue in vivo and for gene therapy based on the electrotransfection of tissues in vivo, is new. PREFERRED ELECTRIC FIELD - The electric field intensity is 4-400 (preferably 30-300) V/cm. It is applied for a total of more than 10 msec in several regular pulses, preferably 1-100,000 pulses at a frequency of 0.1-10,000 Hz, or it is applied in irregular pulses and the function describing the intensity of the field dependent on time of a pulse is variable. The integral of the function describing the variation of the electric field with time is > 1 (preferably \- 5) kV.msec/cm. PREFERRED ELECTRIC PULSES - The electric pulses are in the form of square waves, exponential decay waves, oscillating unipolar waves of limited duration, oscillating bipolar waves of limited duration, or other wave forms.  PREFERRED NUCLEIC ACID - The nucleic acid is administered together with at least some of the components of the organism of origin or the synthesis system. The nucleic acid encodes an RNA (catalytic or antisense) or a protein of interest.
PROBLEM TO BE SOLVED: To obtain the subject powder having high skin-protective effect against ultraviolet radiation of UVA region as well as that of UVB region, and to obtain a cosmetic good in spreadability, high in safety, and capable of giving natural makeup finish with no lurid luster by formulation of the powder. SOLUTION: The objective surface-coated flaky powder is obtained by coating the surface of cloven swellable stratified clay mineral 0.001-0.2μm in thickness and 30-100 in aspect ratio with a zinc oxide. Specifically, it is preferable to obtain the powder by coating the above clay mineral with a zinc salt hydrolyzate followed by baking at 300-700 deg.C to convert the hydrolyzate into the zinc oxide. The other objective cosmetic is obtained by formulation of the above powder. The cloven swellable stratified clay mineral is e.g. smectite, vermiculite, etc., being used either singly or in the combination of at least two of them. The coating proportion of the zinc oxide is >=80wt.% based on the whole flaky powder. Also, the coat may contain an ultraviolet absorber.
BACKGROUND: Acute kidney injury (AKI) is a common and serious complication of ST-elevation myocardial infarction (STEMI). AKI and chronic kidney disease (CKD) are highly heterogeneous, leaving a wide gap between them. Therefore, the term acute kidney disease (AKD) was implemented, describing prolonged renal injury between 7 and 90 days. We aimed to evaluate the prevalence and predictors of AKD among STEMI patients.
METHODS: This retrospective observational study included 2940 consecutive patients admitted with STEMI between 2008 and 2022. Renal function was assessed upon admission and routinely thereafter. Renal outcomes were evaluated according to KDIGO criteria, with AKD defined as persistent renal injury of between 7 and 90 days.
RESULTS: Two hundred and fifty-two subjects with STEMI and AKI were included; of them, 117 (46%) developed AKD. Among baseline CKD patients, higher rates of AKD were observed (60% vs. 46%). KDIGO index ≥ 2 was an independent predictor for AKD in in subjects without baseline CKD (AOR 2.63, 95% CI 1.07-6.53). In subjects with baseline CKD, older age and higher creatinine were independent predictors for AKD. Subjects with AKD had a higher 1-year mortality rate (HR 3.39, 95% CI 1.71-6.72, p < 0.01). This trend was mainly driven by the CKD subpopulation where higher mortality rates for AKD on CKD were observed (HR 5.26, 95% CI 1.83-15.1, p < 0.01).
CONCLUSION: AKD is common among STEMI patients with AKI. The presence of CKD and higher KDIGO stage should prompt strict monitoring for early diagnosis, treatment, and prevention of renal function deterioration.
The SORL1 gene has recently emerged as a strong Alzheimer's Disease (AD) risk gene. Over 500 different variants have been identified in the gene and the contribution of individual variants to AD development and progression is still largely unknown. Here, we describe a family consisting of 2 parents and 5 offspring. Both parents were affected with dementia and one had confirmed AD pathology with an age of onset > 75 years. All offspring were affected with AD with ages at onset ranging from 53 years to 74 years. DNA was available from the parent with confirmed AD and 5 offspring. We identified a coding variant, p.(Arg953Cys), in SORL1 in 5 of 6 individuals affected by AD. Notably, variant carriers had severe AD pathology, and the SORL1 variant segregated with TDP-43 pathology (LATE-NC). We further characterized this variant and show that this Arginine substitution occurs at a critical position in the YWTD-domain of the SORL1 translation product, SORL1. Functional studies further show that the p.R953C variant leads to retention of the SORL1 protein in the endoplasmic reticulum which leads to decreased maturation and shedding of the receptor and prevents its normal endosomal trafficking. Together, our analysis suggests that p.R953C is a pathogenic variant of SORL1 and sheds light on mechanisms of how missense SORL1 variants may lead to AD.
The invention discloses a medicine for treating chronic pain-anxiety co-diseases and a diagnostic kit. The agents include Short Chain Fatty Acids (SCFAs), compounds containing SCFAs moieties, SCFAs precursors, SCFAs biosynthetic precursors, derivatives of SCFAs, and combinations thereof. The administration forms of the combination medicine comprise prodrug, salt, ester or targeted release preparation, and the administration modes are oral administration, sublingual administration, buccal administration and intravenous injection; in addition, the invention also discloses a diagnosisFluorescent quantitative PCR kit for chronic pain-anxiety co-diseases. The kit comprises: specific amplification Desulfovibrio Specific upstream and downstream primers of (a), SYBR Green dye, positive control and negative control. The invention relates to a strain Desulfovibrio The detection of the method is convenient and quick, quantitative analysis can be carried out, and a large number of samples can be detected simultaneously. Provides a new means for diagnosing chronic pain-anxiety co-diseases.
MicroRNAs (miRNAs) are endogenous non-coding RNAs approximately 23 nucleotides in length, playing significant roles in various cellular processes. Numerous studies have shown that miRNAs are involved in the regulation of many human diseases. Accurate prediction of miRNA-disease associations is crucial for early diagnosis, treatment, and prognosis assessment of diseases. In this paper, we propose the Autoencoder Inductive Matrix Completion (AEIMC) model to identify potential miRNA-disease associations. The model captures interaction features from multiple similarity networks, including miRNA functional similarity, miRNA sequence similarity, disease semantic similarity, disease ontology similarity, and Gaussian interaction kernel similarity between miRNAs and diseases. Autoencoders are used to extract more complex and abstract data representations, which are then input into the inductive matrix completion model for association prediction. The effectiveness of the model is validated through cross-validation, stratified threshold evaluation, and case studies, while ablation experiments further confirm the necessity of introducing sequence and ontology similarities for the first time.
The proposed study will consist of a pilot trial of three 12-week, 24-session Tai Chi intervention groups compared with three 12-week, 24-session wellness education control groups. Participants will be randomly assigned in blocks of 14 to either the Tai Chi or the wellness education condition, half to each. Veterans who do not agree to randomization will be excluded. Baseline and post-intervention assessments will be completed, and it is anticipated that 42 individuals will complete baseline assessments. After the final sessions, participants will be asked to provide feedback to investigators via questionnaires, a focus group discussion, and individual interviews utilizing open-ended questions. Information collected from participants will be integrated and utilized for presentations/manuscript preparation, as well as to refine protocols for use in future research.

Potentially eligible veterans who have expressed interest in the study will be called and research staff will describe all aspects of the study. Research staff will answer any questions, and then obtain oral consent for screening for eligibility criteria in the medical record. Study staff will then go through the eligibility criteria over the telephone and schedule a baseline assessment as appropriate. Participants will be mailed information about the time and location for the initial baseline assessment and the class schedule and location to which they are assigned. They will also receive phone calls with this information. Information collected during the telephone screening (prior to completion of the Informed Consent Form) will be collected and retained with the prospective participant's verbal permission. This information will be kept separate from identifying information (names, addresses, and telephone numbers). Some information collected from the electronic medical record will be recorded in order to document inclusion and exclusion criteria.
The kindergartens, teachers, and children will receive the training and SEED curriculum. Upon informed consent from the school principals and parents, parents, teachers, and children will complete pre-, post-, and 4-week follow-up assessments. Focus group interviews will be conducted with teachers to understand their acceptability, demand, practicality, integration, and efficacy of the teacher training at post-teacher training and delivery of the SEED curriculum for children at post-intervention. Another focus group interviews will be conducted with SEED trainers to get information about teachers' participation rate in the training session.
During Cycles 1-3, participants with either PROS (phosphatidylinositol- 4,5-bisphosphate 3-kinase, catalytic subunit alpha \[PIK3CA\]-related Overgrowth Spectrum) or PS (Proteus syndrome) received miransertib 15 mg/m\^2 once daily (QD) (each cycle length = 28 days). From Cycles 4-48 or until disease progression, unacceptable toxicity, or discontinuation, participants received miransertib dose titrated to 25 mg/m\^2 and then titrated to 35 mg/m\^2 orally QD at the investigator's discretion.
Infectious diseases challenge health and welfare of humans and animals. Unlike for humans, breeding of genetically resistant animals is a sustainable solution, also providing unique research opportunities. Chances to survive a disease are improved by disease resistance, but depend also on chances to get infected and infect others. Considerable knowledge exists on chances of susceptible and resistant animals to survive a disease, yet, almost none on their infectivity and if and how resistance and infectivity correlate. Common carp (Cyprinus carpio) is widely produced in aquaculture, suffering significantly from a disease caused by cyprinid herpes virus type 3 (CyHV-3). Here, the infectivity of disease-resistant and susceptible fish types was tested by playing roles of shedders (infecting) and cohabitants (infected) in all four type-role combinations. Resistant shedders restricted spleen viral load and survived more than susceptible ones. However, mortality of susceptible cohabitants infected by resistant shedders was lower than that of resistant cohabitants infected by susceptible shedders. Virus levels in water were lower in tanks with resistant shedders leading to lower spleen viral loads in cohabitants. Thus, we empirically demonstrated that disease resistant fish survive better and infect less, with implications to epidemiology in general and to the benefit of aquaculture production.
Vincristine (VCR), an anti-tubulin chemotherapy agent, is known to cause peripheral and central nerve damage, inducing severe chemotherapy-induced peripheral neuropathy (CIPN). Although melatonin has been recently recognized for its potential anti-neuropathic effects, its efficacy in countering VCR-induced neuropathy remains unclear. This study examines the neuroprotective potential of melatonin against VCR-induced neuropathy using a rat model. Neuropathic pain was induced through 10 VCR injections (0.1 mg/kg/day i.p.), administered in two five-day cycles with a two-day break. Melatonin treatment started two days before VCR administration and continued daily throughout the experiment. Rats were assigned to five groups: control, VCR, and three melatonin-treated groups receiving VCR with melatonin (5, 10, or 20 mg/kg/day i.p.). We assessed mechanical (von-Frey and Randall-Selitto tests) and thermal (hot-plate and tail-flick tests) hyperalgesia, motor coordination (rotarod test), and sciatic nerve conduction velocity (NCV). Changes in body weight, spinal cord histopathology (H&E), and proinflammatory markers (TNF-α, IL-1β, and IL-6), reactive astrocytes (GFAP) and microglial cells (IBA-1) were also assessed, as well as spinal cord degeneration (Nissl stain) and demyelination (LFB stain and MBP). Finally, the effect of melatonin on the cytotoxic activity of VCR against EL4 lymphoma cells was assessed using an MTT assay. Our results indicated that melatonin coadministration with VCR preserved spinal cord architecture, elevated nociceptive thresholds, improved motor coordination, enhanced NCV, and maintained normal body weight gain. Melatonin also reduced inflammation, decreased reactive astrocytes and microglia, and prevented neurodegeneration and demyelination in the spinal cord. Importantly, melatonin did not affect VCR's cytotoxic activity in cancer cells.
<P>PROBLEM TO BE SOLVED: To provide the modulation of a GDF-8 effect on cells.  <P>SOLUTION: This invention relates to use of a protein including at least one follistatin domain modulating the level or activity of a growth and differentiation factor-8 (GDF-8). More specifically, this invention relates to the use of the protein including at least one follistatin domain without containing follistatin itself for the treatment of disorders relating to the modulation of level or activity of GDF-8. The present invention is effective for the treatment of muscle disorders and muscle diseases, particularly for muscle disorders and muscle diseases in which the proliferation of muscle tissues is therapeutically effective. In addition, this invention is effective for the treatment of diseases and disorders relating to metabolism, fat, tissue and degeneration of bones.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Frailty is increasingly prevalent in the aging neurosurgical population and is an important component of perioperative risk stratification and optimization to reduce complications. Frailty is measured using the phenotypic or deficit accumulation models, with simplified tools most commonly used in studies of neurosurgical patients. There are a limited number of frailty measurement tools that have been validated for individuals with neurological disease, and those that exist are mainly focused on spine pathology. Increasing frailty consistently predicts worse outcomes for patients across a range of neurosurgical procedures, including early complications, disability, non-home discharge, and mortality. Evidence for interventions to improve outcomes for frail neurosurgical patients is limited, and the role of bundled care pathways, prehabilitation, and multidisciplinary involvement requires further investigation. Surgery itself may be an intervention to improve frailty in selected patients, and future research should focus on identifying effective interventions to improve both short-term complications and long-term outcomes.
FIELD: chemical-pharmaceutical industry. SUBSTANCE: invention relates to the improved technology of preparing benzylpenicillin K(Na) salt for injection. An aqueous-organic concentrate of benzylpenicillin K(Na) salt is subjected for sterilizing filtration. Definite volume of an organic solvent is added to an aqueous-organic concentrate of benzylpenicillin K(Na) salt in order to decrease water content in total volume of a mixture of an aqueous-organic concentrate and an organic solvent to minimal value (2-3%). The claimed method exhibits the following features: 1. The parent aqueous-organic concentrate of benzylpenicillin K(Na) salt has from 10% to 30% water and from 40% to 60% benzylpenicillin K(Na) salt. 2. Volume of an organic solvent used for crystallization is from 10 to 15 volumes of the parent volume of aqueous-organic concentrate. 3. After mixing an aqueous-organic concentrate of benzylpenicillin K(Na) salt with 10-15 volumes of a solvent a suspension of benzylpenicillin K(Na) salt containing from 2% to 3% water is formed. EFFECT: improved method of preparing, increased yield and improved quality of the end product, simplified technological process. 3 cl, 3 ex
Matched controls (age, sex) composed the 3rd and 4th group (BPD control and other PD control). They were randomly chosen in the health database insurance previously used. They had no intervention.