anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Preeclampsia (PE) is associated with high maternal and perinatal morbidity and mortality. The development of effective treatment strategies remains a major challenge due to the limited understanding of the pathogenesis. In this review, we summarize the current understanding of PE research, focusing on the molecular basis of mitochondrial function in normal and PE placentas, and discuss perspectives on future research directions. Mitochondria integrate numerous physiological processes such as energy production, cellular redox homeostasis, mitochondrial dynamics, and mitophagy, a selective autophagic clearance of damaged or dysfunctional mitochondria. Normal placental mitochondria have evolved innovative survival strategies to cope with uncertain environments (e.g., hypoxia and nutrient starvation). Cytotrophoblasts, extravillous trophoblast cells, and syncytiotrophoblasts all have distinct mitochondrial morphology and function. Recent advances in molecular studies on the spatial and temporal changes in normal mitochondrial function are providing valuable insight into PE pathogenesis. In PE placentas, hypoxia-mediated mitochondrial fission may induce activation of mitophagy machinery, leading to increased mitochondrial fragmentation and placental tissue damage over time. Repair mechanisms in mitochondrial function restore placental function, but disruption of compensatory mechanisms can induce apoptotic death of trophoblast cells. Additionally, molecular markers associated with repair or compensatory mechanisms that may influence the development and progression of PE are beginning to be identified. However, contradictory results have been obtained regarding some of the molecules that control mitochondrial biogenesis, dynamics, and mitophagy in PE placentas. In conclusion, understanding how the mitochondrial morphology and function influence cell fate decisions of trophoblast cells is an important issue in normal as well as pathological placentation biology. Research focusing on mitochondrial function will become increasingly important for elucidating the pathogenesis and effective treatment strategies of PE.
PROBLEM TO BE SOLVED: To obtain the subject optically pure androgen mediator that is useful for treatment of wasting disease in mammalians including human, for example, the prevention of and the recovery from the reduction in the muscular mass and power of age dependency and for treatment of the morbid states bringing about the low bone mass. SOLUTION: This compound represented by the formula or its pharmaceutically acceptable salts are provided by this invention. In a preferred embodiment, the compound of the formula is in the form of a free base. The compound of the formula is synthesized by starting with the reaction of anisidine with acrylic acid. The compound of the formula can treat infirmity, osteoporosis or wasting diseases of mammalians and is dosed to the mammalians, preferably humans to be treated in an effective amount, preferably 0.01-10 mg/kg/day. The compound of the formula is preferably used in the form of a pharmaceutical composition including pharmaceutically acceptable vehicle, diluent or carrier.
Fibrosis is characterized by excessive deposition of extracellular matrix proteins, particularly collagen, caused by myofibroblasts in response to chronic inflammation. Although G protein-coupled receptors (GPCRs) are among the targets of current antifibrotic drugs, no drug has yet been approved to stop fibrosis progression. Herein, we aimed to identify GPCRs with profibrotic effects. In gene expression analysis of mouse lungs with induced fibrosis, eight GPCRs were identified, showing a >2-fold increase in mRNA expression after fibrosis induction. Among them, we focused on Gpr176 owing to its significant correlation with a myofibroblast marker α-smooth muscle actin (αSMA), the profibrotic factor transforming growth factor β1 (TGFβ1), and collagen in a human lung gene expression database. Similar to the lung fibrosis model, increased Gpr176 expression was also observed in other organs affected by fibrosis, including the kidney, liver, and heart, suggesting its role in fibrosis across various organs. Furthermore, fibroblasts abundantly expressed Gpr176 compared to alveolar epithelial cells, endothelial cells, and macrophages in the fibrotic lung. GPR176 expression was unaffected by TGFβ1 stimulation in rat renal fibroblast NRK-49 cells, whereas knockdown of Gpr176 by siRNA reduced TGFβ1-induced expression of αSMA, fibronectin, and collagen as well as Smad2 phosphorylation. This suggested that Gpr176 regulates fibroblast activation. Consequently, Gpr176 acts in a profibrotic manner, and inhibiting its activity could potentially prevent myofibroblast differentiation and improve fibrosis. Developing a GPR176 inverse agonist or allosteric modulator is a promising therapeutic approach for fibrosis.
Methods and systems for obtaining reference data from one or more EMR systems are described. A universal API request may be sent from an external application server to middleware. The universal API request may be translated into an EMR-specific request via the middleware. The EMR-specific request may be sent to the selected EMR system. An EMR-specific response may be received from the one or more EMR systems at the middleware, being generated by the selected EMR systems. The EMR-specific response may be translated into a universal API response via the middleware. The universal API response may be received at the external application server from the middleware.
Anterior cruciate ligament (ACL) rupture is one of the most common sports injuries. Surgical procedure is usually performed after injury. After ACL surgery, patients experience problems such as pain, impaired knee function, and especially quadriceps muscle weakness and atrophy. Quadriceps atrophy has been shown to persist for years despite rehabilitation programs. Therefore, rehabilitation programs after ACL reconstruction play an important role in ensuring return to sports and reducing postoperative complications. In general, ACL rehabilitation can be divided into early and late periods. In the early period, while focusing on the solution of the primary problems related to the knee (pain, edema, joint movement limitation, quadriceps muscle weakness, and antalgic gait), the focus is on the patient's preparation for returning to sports activities. Running, jumping and agility training are the exercise approaches of late phase rehabilitation. These exercises include pliometric activities that trigger the stretch-shortening cycle of the lower extremity extensor muscles. Pliometric exercises after anterior cruciate ligament reconstruction may improve lower extremity muscle strength and knee function and increase the rate of return to sports, but there is not enough study in this area. Under normal conditions, 6-12 repetitive weight-lifting exercises at a density of at least 65% of a maximum repetition are recommended to increase strength in a muscle and achieve hypertrophy. However, it takes approximately 4-6 months for the ligament to mature and bear weight after surgery. For this reason, high intensity strengthening training is not used in the early period of rehabilitation to protect the graft that is recovering after surgery and the training is started from low intensity and increased gradually. Recent studies suggest that muscle hypertrophy occurs with low-intensity exercises (20-30% of a maximum repetition) with blood flow restriction, also known as KAATSU training or occlusion training. Because blood flow restriction training allows the benefits of high intensity training to be obtained at a much lower intensity. In the literature, the effectiveness of many different exercise programs after ACL reconstruction was investigated. However, no study investigating the effect of blood flow restriction plyometric exercise training on ACL rehabilitation on muscle strength and function was found. This study will be conducted to investigate the contribution of low-density plyometric training with blood flow restriction to atrophy, muscle strength, function and return to sports.
Study TKT024EXT was conducted in 2 phases. The first phase ("Phase I") was 2 years (104 weeks) in duration and consisted of weekly infusions of IV idursulfase (0.5 mg/kg), and the collection of patients' safety and clinical outcomes. Week 105 defined the beginning of the second phase of the study. The second phase ("Phase II") consisted of weekly infusions of IV idursulfase (0.5 mg/kg) and the monitoring of patients for safety (via collection of adverse events, concomitant medications, and vital signs). Study completion was defined as the time a patient either transitioned to commercially available idursulfase or discontinued this study.

Idursulfase was administered to patients as a continuous IV infusion at a dose of 0.5 mg of protein per kg of body weight (0.5 mg/kg). Final evaluations from Study TKT024, the one-year predecessor Phase 2/Phase 3 registration study, served as the baseline assessments for the TKT024EXT study. Forced vital capacity (FVC) and the 6-minute walk test (6MWT) continued to be the primary clinical outcomes of TKT024EXT study. Efficacy outcomes were evaluated over the course of 2 years and were determined at 4-month intervals during the first year (ie, Weeks 18, 36, and 53) and at 6-month intervals in the second year (ie, Weeks 79 and 105). Safety outcomes were assessed throughout the duration of the study. The safety and clinical testing performed in the TKT024EXT study were identical to those performed in the double-blind phase of Study TKT024.
Strength and endurance training are often done concurrently by fitness enthusiasts and athletes. Concurrent strength and endurance training however, result in "antagonism" of the training responses. Combined strength and endurance training in previously untrained subjects has developed strength impairment in comparison to strength training alone, whereas endurance development, expressed as increases in maximal aerobic power has not been impaired. A combination of some forms of strength and endurance training maybe "addictive" rather than antagonistic. Some endurance training programs have increases strength and muscle fiber size. A randomized controlled trial will be conducted. Non-probability convenient sampling technique will be used. Study will be carried in hockey clubs at Lahore. Only female players of age 18-24 with one year experience in hockey, only players who will participate in all training sessions will be included in the statistical analysis. Participants with the history of systemic disease, with history of lower extremity and lumber spine pathology, with prior surgery history and participants having injuries resulting in loss of one or more hockey matches/ training sessions in the preceding three months prior to the initiation of the study will be excluded. Three groups will be included in the study each containing 10 participants. Group A will be given plyometric training for 12 weeks, Group B will be given endurance training for 12 weeks and Group C will be given both trainings for 12 weeks. Pre-training values will be taken prior training. Mid-training values will be taken after 6 weeks of training and post-training values will be taken after training.
Dementia impacts 5%-7% of individuals \>60 years old. It impacts the person's ability to perform work, care for him/herself and ultimately leads to physical disability. There is a high caregiver burden associated with dementia and many individuals require care in a long-term care facility. There is some emerging evidence that music based interventions may have a protective effect on the brain in those with dementia. There is also evidence that doing activities that engage the brain through music are beneficial. This study seeks to investigate the potential benefits of a music based intervention for individuals with dementia. The study aims to recruit individuals with a diagnosis of dementia. Once enrolled participants will undergo assessment of walking, balance and cognition and then be asked to participate either in a dance class or to listen to live music. After 6 weeks and again at the end of the study (after 12 weeks) participants will undergo assessments of walking, balance and cognition.
Replacement of the temporomandibular joint (RTJ) has undergone decades of technological improvements and is now an important treatment for end-stage temporomandibular joint (TMJ) disease. The main complications of RTJ include aseptic loosening, heterotopic ossification, postsurgical infection, hypersensitivity reaction, prosthesis loosening or malposition, nerve injury and severe bleeding. Improvement in clinical technique is now the key to resolving complications. In the future, improvements in prosthetic materials may be an important development for newer iterations. With the development and popularity of TMJ surgical techniques, prosthesis-related complications will increasingly come into clinical view. This article provides a systematic review of the complications of RTJ prosthesis replacement and the measures to deal with them, and looks forward to the direction of the development of this field from the perspective of reducing complications, so as to provide a reference for clinical work.
This arm consists of students waitlisted for Dartmouth College's Biology 3 course during Spring 2024 term. They will receive university wellness resources as usual. These include access to wellness counselors, mental health advisors, and psychiatrists at the university's counseling center, wellness advising at the student wellness center, and campus-wide wellness programs, such as weekly group yoga and meditation sessions and a free subscription to the Headspace app. The 4-hr mindfulness retreat will also be advertised to and open to all Dartmouth students.
The invention relates to a food supplement for alleviating metabolic deficiency and containing pantothenic acid (CoA), precursors thereof and/or salts thereof and also to a method for production thereof and to use thereof. Fields of application of the invention are the food industry and medicine. The invention is based on the surprising discovery that the uptake of pantothenic acid, pantothenic acid-CoA and/or derivatives thereof in a large amount has an advantageous effect on symptoms which are caused by metabolic deficiency. The core of the invention is that the uptake of a pantothenic acid-CoA equivalent from the diet must be not 10 mg per day, but more than 10 3  times that, in order to supply the human body optimally. Surprisingly, it was likewise found that the cholinergic panthenol-CoA uptake reaction from food took place within the course of a few minutes. The food supplement according to the invention comprises 85-99% pantothenic acid, precursors thereof, derivatives thereof and/or salts thereof and optionally further additives.
The goal intrapartum glucose target range will be 70-110mg/dl. Insulin infusion will be initiated when maternal capillary glucose exceeds 110 mg/dL.
System and methods for automatically identifying anatomical regions in medical images are disclosed. A signature is computed from one or more images of a patient. The signature comprises a water equivalent diameter distribution generated from one or more images of the patient. A best matching atlas element is identified from an atlas. The atlas includes a group of atlas elements, each atlas element includes landmarks associated with a set of image data, and a signature associated with the set of image data. The signature of the best matching atlas element matches the signature of the patient the best among the atlas. Landmarks of the best matching atlas element are projected onto an image of the patient. The method can be used on its own for anatomy localization or used in conjunction with another anatomy localization method to correct the result of another method.
The present invention discloses a method for executing circular symmetrical anisotropic filtering in the extended ellipse or rectangular track in the single-channel digital picture deformation and a system. When the filtering is executed the ellipse is found and adjusted, and the ellipse is approximate to the non-homogeneous image scaling function at the mapping position of the output pixel in the input image space. The linear transformation from the ellipse to the unit circle in the input image space is confirmed to calculate the input image radius in the track and a corresponding wave filter coefficient as the function of the radius. Compromise is executed between the image quality and the processing speed to confirm the track shape. In one embodiment the profiles of the smooth and deformed parts are combined together to generate more clear or detail-reinforced output image. The method and system of the invention can generate lifelike output image without sawtooth distortion and at the same time the definition of the input image can be remained or reinforced.
Do you the present invention relates to Lycojaponicumin? the application of C in preparation treatment leukemia medicament, belongs to field of medicaments.Lycojaponicumin? the application of C in preparation treatment leukemia medicament; Lycojaponicumin? does C suppress the application in Leukemia Cell Proliferation medicine in preparation, Lycojaponicumin? the application of C in preparation induced apoptosis in leukemia cell lines medicine.Lycojaponicumin? C, by suppressing Leukemia Cell Proliferation and induced apoptosis in leukemia cell lines, treats leukemia.For the Lycojaponicumin that the present invention relates to? the purposes of C in preparation treatment leukemia medicament belongs to first public, and because framework types belongs to brand-new framework types, and its inhibit activities for leukaemia is unexpectedly strong.
This is a Phase 1, randomized, placebo-controlled, multicenter study of JNJ-55920839. The study consists of Screening Period of 28 days. The healthy participants will have a 6-day/5-night inpatient period. All Participants will receive study agent on Day 1 and SLE Participants will receive additional doses on Days 15, 29, 43, 57, and 71. The total duration of participation for each participant will be approximately 13 weeks for healthy participants, 22 weeks for participants with SLE. All eligible participants will be randomly assigned to receive active agent or placebo. The study will be conducted in 2 parts. In Part 1, single ascending doses of JNJ55920839 or placebo will be administered to sequential cohorts of healthy participants as an IV infusion or as a subcutaneous injection. In Part 2, multiple doses of JNJ-55920839 or placebo will be administered as IV infusions to participants with SLE. Blood samples will be collected for assessment of pharmacokinetic and pharmacodynamics parameters in both part 1 and 2, along with assessment of safety and clinical outcomes. Participants' safety will be monitored throughout the study.
Gas embolization is a rare but potentially deadly complication of any laparoscopic surgery. There has only been one other report of gas emboli in patients undergoing bariatric surgery. We present a case of gas embolization in a young female patient undergoing Roux-en-Y gastric bypass. Onset of gas embolus was identified by a dramatic drop in End Tidal Carbon Dioxide (ETCO2) followed by drops in blood pressure, heart rate, and oxygen saturation over the following 15 minutes before the patient was stabilized and transferred to the ICU. The surgery was completed three days later without incident, and extensive hepatomegaly was identified. A discussion on pre-operative evaluation, special considerations, and acute management of gas embolization in patients with obesity ensues. We highlight the emerging Jain's point for insufflation, the potential for ultrasound-guided Verres needle insertion, and the paucity of literature evaluating the risk, incidence, and outcomes of gas embolization in patients with obesity.
Methods for tissue welding using solders incorporating biologically active agents, such as growth factors or hemostatic agents, have been developed.  Improved solder compositions have also been defined, yielding greater bursting strength as a function of protein concentration, and through the use of protein unfolding prior to laser-mediated denaturation and coupling. A method for repair of fistulas has been discovered, using water as a chromophore, in combination with solder concentration, to form columns to fill defects where tissue apposition is not possible. Methods have also been adapted for use with other forms of directed energy, including bipolar electrosurgery and light.  Examples demonstrate increased strength of repairs by incorporation of growth factors into solders, alone and as a function of solder concentration.  Increased adhesion is obtained through prevention of bleeding by incorporation of hemostatic agents such as thrombin or epinephrine, a vasoconstrictor.
In Italy, myeloma accounts for 1.3% of all tumour diagnoses in males and for 1.2% of all tumour diagnoses in women. The incidence is 9.5 new cases per 100,000 males and 8.1 cases per 100,000 females. Median age at diagnosis is 68 years and approximately 2% of patients experience onset before the age of 4011. Therefore is to establish a national disease registry to monitor current routine clinical practice in Italy and to describe the standard of care adopted for the diagnosis and treatment of patients with myeloma. National registries have already been established in some countries and a recently-published meta-analysis highlighted certain differences in treatment, survival and the demographic characteristics of patients. An Italian national registry is important for analysing the current situation, in order to deal with the changes that lie ahead. In addition to the standard epidemiological registry - as described in the statistical methods section - a patientpowered registry (PPR) will also be established to encourage patient participation.
BACKGROUND & AIMS: There is limited evidence regarding the association of sarcopenia with dysphagia and physical function in patients with heart failure. This study examined the association between possible sarcopenia and both swallowing and physical function in individuals with acute heart failure (AHF).
METHODS: This prospective cohort study included hospitalized patients with AHF. Possible sarcopenia was assessed on admission using calf circumference and grip strength according to an international diagnostic criteria. The primary outcome was dysphagia at discharge using the Food Intake Level Scale (FILS), and the secondary outcome was physical function at discharge using the Barthel Index (BI). Multiple regression analysis and logistic regression, adjusted for potential confounders, were used to examine the association between possible sarcopenia at admission and FILS and BI at discharge.
RESULTS: A total of 320 patients (mean age 81.5 years; 170 women) were included in the analysis; 199 (59.4%) were diagnosed with possible sarcopenia. Multivariate analysis showed that possible sarcopenia at admission was significantly associated with FILS at discharge (β = -0.1204; p = 0.039). Possible sarcopenia at admission was not significantly associated with BI at discharge (OR = 2.066; 95% CI, 0.910-4.692, p = 0.083).
CONCLUSIONS: Possible sarcopenia was associated with decline in swallowing function during hospitalization in patients with AHF. These findings highlight the need for early detection and treatment of possible sarcopenia in this setting.