anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To obtain a drug excellent in storage stability and persisting property by applying a regenerated and aqueous dispersion liquid of a specified binder on the core containing the effective substance. CONSTITUTION: An aqueous dispersion liquid of a binder is obtd. by emulsion polymn. with a pharmaceutically allowed material such as methylmethacrylate. The obtd. dispersion liquid, a water-soluble and pharmaceutically allowed spray assistant having >=60 deg.C glass transition temp. such as methylcellulose by 5 to 50 wt.% of the binder, and a pharmaceutically allowed adhesion preventive such as talc by 0 to 50 wt.% are spray-dried together and then again prepared as a regenerated and aqueous dispersion liquid. The obtd. liquid is applied on the core containing the effective substance to obtain the drug of the purpose.
Consenting and eligible patients will receive adaptive short course radiation therapy (SCRT) (25 Gy at in 5 fractions), followed by standard of care total neoadjuvant chemotherapy followed by standard of care gastrectomy or esophagogastrectomy. The recommended SOC chemotherapy options are CAPOX, FOLFOX, or FLOT, but any SOC total neoadjuvant chemotherapy may be given at the discretion of the treating medical oncologist after consultation with the study chair. Patients who are not able to complete their full total neoadjuvant therapy regimen prior to surgery may complete chemotherapy postoperatively at the discretion of the treating physician.
MSCs will be given at a median dose of 1×10\^6 cells/kg once weekly for 4 dose (as 1 cycle) or until CR. The response should be evaluated at 3 and 4 weeks. If symptoms of aGVHD progress at 3 weeks or the patients have NR at 4 weeks, these patients will switch to other therapy. If patients achieved PR at 4 weeks, another cycle will be given. Besides, CD25 monoclonal antibody (20mg/kg) will be administered at day 1,4,8,15, 21 and calcineurin inhibitors will also be used.
Patients receive erlotinib as patients in Arm A and cabozantinib as patients in Arm B. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
A nutritional polypeptide having a branched structure and efficient broad-spectrum antibacterial and antifungal functions. The nutritional polypeptide having the branched structure is a polymer peptide which has a molecular weight of 3000-7000 Da and a polydispersity index of less than 1.2 and contains L-lysine and D-lysine structural units. The polypeptide having the branched structure has efficient broad-spectrum antimicrobial effects against bacteria, fungi and mycoplasmas at a low concentration, and does not generate drug resistance. Compared with common antimicrobial agents, the polypeptide has an excellent biocompatibility, no cytotoxicity, and no side effects on animals after intravenous injection, and can meet the antimicrobial requirements of intravenous injection in vivo. The degradation product of the polypeptide is lysine, which is an essential nutrient for organisms, and has no toxic or side effects. The polypeptide having the branched structure does not require a biological fermentation process, is completely chemically synthesized, has stable physical, chemical and biological properties, and can be combined with other materials by means of physical or chemical methods to synthesize or process same into various forms of materials while maintaining efficient antimicrobial properties.
BACKGROUND: Diabetic foot ulcer (DFU) is one of the main chronic complications caused by diabetes, leading to amputation in severe cases. Bacterial infection affects the wound healing in DFU.
METHODS: DFU patients who met the criteria were selected, and the clinical data were recorded in detail. The pus exudate from the patient's foot wound and venous blood were collected for biochemical analysis. The distribution of bacterial flora in pus exudates of patients was analyzed by 16S rRNA sequencing, and the correlation between DFU and pathogenic variables, pyroptosis and immunity was analyzed by statistical analysis. Then, the effects of key bacteria on the inflammation, proliferation, apoptosis, and pyroptosis of polymorphonuclear leukocytes were investigated by ELISA, CCK-8, flow cytometry, RT-qPCR and western blot.
RESULTS: Clinical data analysis showed that Wagner score was positively correlated with the level of inflammatory factors, and there was high CD3+, CD4+, and low CD8+ levels in DFU patients with high Wagner score. Through alpha, beta diversity analysis and species composition analysis, Corynebacterium accounted for a large proportion in DFU. Logistics regression model and Person correlation analysis demonstrated that mixed bacterial infections could aggravate foot ulcer, and the number of bacteria was closely related to inflammatory factors PCT, PRT, immune cells CD8+, and pyroptosis-related proteins GSDMD and NLRP3. Through in vitro experiments, Corynebacterium inhibited cell proliferation, promoted inflammation (TNF-α, PCT, CRP), apoptosis and pyroptosis (IL-1β, LDH, IL-18, GSDMD, NLRP3, and caspase-3).
CONCLUSION: Mixed bacterial infections exacerbate DFU progression with a high predominance of Corynebacterium, and Corynebacterium promotes inflammation, apoptosis and pyroptosis to inhibit DFU healing.
Modern mental fatigue detection methods include many parameters for evaluation. For example, many researchers use human subjective evaluation or driving parameters to assess this human condition. Development of a method for detecting the functional state of mental fatigue is an extremely important task. Despite the fact that human operator support systems are becoming more and more widespread, at the moment there is no open-source solution that can monitor this human state based on eye movement monitoring in real time and with high accuracy. Such a method allows the prevention of a large number of potential hazardous situations and accidents in critical industries (nuclear stations, transport systems, and air traffic control). This paper describes the developed method for mental fatigue detection based on human eye movements. We based our research on a developed earlier dataset that included captured eye-tracking data of human operators that implemented different tasks during the day. In the scope of the developed method, we propose a technique for the determination of the most relevant gaze characteristics for mental fatigue state detection. The developed method includes the following machine learning techniques for human state classification: random forest, decision tree, and multilayered perceptron. The experimental results showed that the most relevant characteristics are as follows: average velocity within the fixation area; average curvature of the gaze trajectory; minimum curvature of the gaze trajectory; minimum saccade length; percentage of fixations shorter than 150 ms; and proportion of time spent in fixations shorter than 150 milliseconds. The processing of eye movement data using the proposed method is performed in real time, with the maximum accuracy (0.85) and F1-score (0.80) reached using the random forest method.
A few cases have shown that bee stings can be linked to coronary stent thrombosis. However, instances of recurrent myocardial infarction resulting from bee stings among patients who have successfully undergone revascularization treatment are rare. This case report describes a man in his early 60s who experienced an acute myocardial infarction. The left anterior descending coronary artery was revascularized by a drug-eluting stent. Just 1 week later, the patient experienced a second acute myocardial infarction and it occurred immediately after a bee sting. Angiography revealed stent thrombosis so thrombus aspiration was performed. Subsequently, the blood flow in the stent was unobstructed. Follow-up coronary angiography 1 year later revealed no signs of restenosis within the stent. Hymenoptera venoms contains thrombogenic substances that might lead to acute stent thrombosis.
Provided is a treating or preventing agent for the eye disease caused by eye angiogenesis, which contains a morpholin compound represented by formula (1) or its salt as active ingredient. [wherein, ring A represents an optionally substituted aryl etc.; ring B represents an optionally substituted arylene etc.; m=0~2; n=1~5; X represents a bond etc.; Y represents a bond etc.; Z represents a hydrogen etc.].
Hypoxia-inducible factor-1 (HIF-1) is the master regulator of cellular response to hypoxia, and is activated in many cancers contributing to many steps in the metastatic cascade by acting as a key transcription co-regulator for a large number of downstream genes. Presence of hypoxia within a tumor is spatially nonuniform, and can also by dynamic. Further, although HIF-1 is primarily stabilized and activated by lack of molecular O2, its stability is also affected by other factors present in the tumor microenvironment. HIF-1 also crosstalks with other transcription factors in co-regulating gene expression. Consequently, it is nontrivial to predict the gene expression patterns in cells in response to hypoxia, or HIF-1 activation. Additionally, cancers originating from tissue origins with different basal level of partial oxygen tension may activate HIF-1 at different threshold of hypoxia. We analyzed large published single cell RNAseq data for colorectal, lung, and pancreatic cancers to investigate the phenotypic outcome of HIF-1 activation in cancer cells. We found that cancers from tissues with different partial O2 tension levels exhibit HIF-1 activation at different stages of metastasis, and phenotypically respond differently to HIF-1 activation, likely by contextual co-option of different transcription factors. We experimentally confirmed these predictions by using cell lines representative of colorectal, lung, and pancreatic cancers, finding that while hypoxia enhances growth of colorectal cancer, it induces increased invasion of lung, and pancreatic cancers. Our analysis suggest that HIF-1 activation may act as a rheostat regulating downstream gene expression towards phenotypic outcomes differently in various cancers.
Alzheimer's disease (AD), a prevalent neurodegenerative disorder, leads to progressive dementia, which impairs decision-making, problem-solving, and communication. While there is no cure, early detection can facilitate treatments to slow its progression. Deep learning (DL) significantly enhances AD detection by analyzing brain imaging data to identify early biomarkers, improving diagnostic accuracy and predicting disease progression more precisely than traditional methods. In this article, we propose an ensemble methodology for DL models to detect AD from brain MRIs. We trained an enhanced Xception architecture once to produce multiple snapshots, providing diverse insights into MRI features. A decision-level fusion strategy was employed, combining decision scores with a RF meta-learner using a blending algorithm. The efficacy of our ensemble technique is confirmed by the experimental findings, which categorize Alzheimer's into four groups with 99.14% accuracy. This methodology may help medical practitioners provide patients with Alzheimer's with individualized care. Subsequent efforts will concentrate on enhancing the model's efficacy via its generalization to a variety of datasets.
Patients with Richter's transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma (DLBCL-RT) face a dismal prognosis. A 51-year-old female patient diagnosed with CLL with deletion (17p) in 2009. CLL treatment included chemoimmunotherapy and targeted substances. DLBCL-RT was diagnosed in November 2016. After receiving an allogeneic hematopoietic stem cell transplantation, she relapsed in September 2019 and tisagenlecleucel was infused in December 2019. Cytokine release syndrome grade 2 was treated with two doses of tocilizumab and the patient was started on 140 mg ibrutinib in February 2020. Our patient remains in remission up to 4 years after CAR T-cell treatment.
Asthma is a chronic pulmonary disease with marked infiltrating inflammatory cells and reduced respiratory performance. Echinochrome (Ech) is a dark-red pigment isolated from the sea urchin spines, shells, and ova. It has antioxidant, antimicrobial, and anti-inflammatory properties, but whether it can be used in asthma treatment has yet to be investigated. In this research, we aimed to study the inhibitory actions of Ech on allergic asthma symptoms in mice. Mice were divided into 4 groups (n = 8 for each): control, ovalbumin-challenged, and Ech-treated (0.1 and 1 mg/kg). At the end of the experiment, nasal scratching, lung oxidative stress, airway inflammation, and remodeling were assessed. In ovalbumin-challenged BALB/C mice, treatment with Ech significantly decreased nasal scratching, lung oxidative stress, inflammatory cell infiltration, mucus hyperproduction and hyperplasia of goblet cells, IgE levels, and inflammatory cytokines. It also inhibited NF-κB phosphorylation. This is the first study to investigate the immunomodulatory effect of Ech against allergic asthma in mice. According to our findings, we imply that Ech may be utilized as a treatment for allergic asthma.
Original models of plaster are obtained from impressions of the dentition of the upper and lower jaws of a patient with malocclusion. The teeth are then separated from the base of the models and reset in wax to a normal occlusion. The realigned teeth are fixed in place with wax, and impressions of the upper and lower models are taken to duplicate the rearranged models, forming working models made of plaster. The working models are mounted on an anatomic dental articulator and a wax occluding model is constructed of the new occlusion to cover both upper and lower arches. The working upper and lower models, together with the wax occluding model are buried in plaster in a split cast. The wax occluding model in the split cast is heated and the wax is melted and discharged out of the cast. Silicone resin is then placed into the impression of the occluding model and cured.
Tizanidine is an α2-adrenergic agonist (like clonidine) and can produce hypotension. In a single dose study where blood pressure was monitored closely after dosing, two-thirds of patients treated with 8 mg of tizanidine had a 20% reduction in either the diastolic or systolic BP. The reduction was seen within 1 hour after dosing, peaked 2 to 3 hours after dosing and was associated, at times, with bradycardia, orthostatic hypotension, lightheadedness/dizziness and rarely syncope. The hypotensive effect is dose related and has been measured following single doses of ≥ 2 mg.

The chance of significant hypotension may possibly be minimized by titration of the dose and by focusing attention on signs and symptoms of hypotension prior to dose advancement. In addition, patients moving from a supine to fixed upright position may be at increased risk for hypotension and orthostatic effects.

Caution is advised when tizanidine is to be used in patients receiving concurrent antihypertensive therapy and should not be used with other α2-adrenergic agonists.

Clinically significant hypotension (decreases in both systolic and diastolic pressure) has been reported with concomitant administration of either fluvoxamine or ciprofloxacin and single doses of 4 mg of tizanidine. Therefore, concomitant use of tizanidine with fluvoxamine or with ciprofloxacin, potent inhibitors of CYP1A2, is contraindicated (see CONTRAINDICATIONS and CLINICAL PHARMACOLOGY: Drug Interactions).
SYLVANT may cause infusion related reactions and anaphylaxis. Approximately 945 patients have been treated with SYLVANT in clinical trials. Of these, one patient experienced an anaphylactic reaction. Data from 254 patients treated with SYLVANT monotherapy forms the basis of the safety evaluation of infusion related reactions. Infusion related reactions were reported in 5.1% of these patients. Two (0.8%) were Grade 3 or higher, and 1 (0.4%) was serious; none were fatal. Symptoms of infusion reactions consisted of back pain, chest pain or discomfort, nausea and vomiting, flushing, erythema, and palpitations.

In long-term treatment of MCD patients with siltuximab at the recommended dosage of 11 mg/kg every 3 weeks, infusion related reactions or hypersensitivity reactions occurred at a frequency of 6.3% (1.3% for severe reactions).

Stop the infusion of SYLVANT if the patient develops signs of anaphylaxis. Discontinue further therapy with SYLVANT.

Stop the infusion if the patient develops a mild to moderate infusion reaction. If the reaction resolves, the SYLVANT infusion may be restarted at a lower infusion rate. Consider medication with antihistamines, acetaminophen, and corticosteroids. Discontinue SYLVANT if the patient does not tolerate the infusion following these interventions [see Adverse Reactions (6)].

Administer SYLVANT in a setting that provides resuscitation equipment, medication, and personnel trained to provide resuscitation.
1. Technical Result Increase in efficiency of treatment of conditions associated with pathological matrix metalloprotease activity.                 2. Essence A compounds of formula wherein R1, R2, R3a, R3b and R20 are as described in the specification; use of this compound and pharmaceutically acceptable salts thereof for treatment of conditions associated with pathological matrix metalloprotease activity (MMP).         3. Field of Application Medicine.                Tables: 221
In conventional therapy group, donepezil was the commonly used ChEI(cholinesterase inhibitor) to treat mild to severe AD patients. Memantine, a NMDA(N-methyl-D-aspartate ) antagonist, was given to moderate and severe AD patients. The dose of donepezil ranged from 5 to 10 mg once a day according to patients.
The invention belongs to the field of ethnic minority medicines and discloses a Yao medicine composition for treating diabetes mellitus and a preparation method thereof. The composition comprises 3-30 parts by weight of fruit of rhodomyrtus tomentosa(Ait.)Hassk, 6-60 parts by weight of zea mays L., 3-30 parts by weight of pueraria edulis Pamp., 3-30 parts by weight of tuber of dioscorea opposita Thunb., 2-20 parts by weight of siraitia grosvenorii(Swingle)C.Jeffrey ex A.M.Luet Z.Y.Zhang, 3-30 parts of lyceum chinense Mill. and 3-30 parts by weight of fruit of morns alba L. The dosage form of the composition is powder or tea bags. The preparation method comprises the processes of grinding, baking and sterilizing the raw medicines, thus preparing the powder or tea bags. Clinical tests show that the Yao medicine composition has the functions of nourishing the lung and the kidney, removing heat to cool blood, engendering liquid and allaying thirst, relieving alcoholism to activate the spleen, removing liver-fire for improving eyesight and nourishing yin for moistening dryness, takes effect quickly, has stable curative effects and no toxic or side effect and is a health protection medicine with preventive and therapeutic effects on diabetes mellitus.
Epigenetic modifications influenced by environmental exposures are molecular sources of phenotypic heterogeneity found in schizophrenia and bipolar disorder and may contribute to shared etiopathogenetic mechanisms of these two disorders. Newborns who experienced perinatal asphyxia have suffered reduced oxygen delivery to the brain around the time of birth, which increases the risk of later psychiatric diagnosis. This study aimed to investigate DNA methylation in blood cells for associations with a history of perinatal asphyxia, a neurologically harmful condition occurring within the biological environment of birth. We utilized prospective data from the Medical Birth Registry of Norway to identify incidents of perinatal asphyxia in 643 individuals with schizophrenia or bipolar disorder and 676 healthy controls. We performed an epigenome wide association study to distinguish differentially methylated positions associated with perinatal asphyxia. We found an interaction between methylation and exposure to perinatal asphyxia on case-control status, wherein having a history of perinatal asphyxia was associated with an increase of methylation in healthy controls and a decrease of methylation in patients on 4 regions of DNA important for brain development and function. The differentially methylated regions were observed in genes involved in oligodendrocyte survival and axonal myelination and functional recovery (LINGO3); assembly, maturation and maintenance of the brain (BLCAP;NNAT and NANOS2) and axonal transport processes and neural plasticity (SLC2A14). These findings are consistent with the notion that an opposite epigenetic response to perinatal asphyxia, in patients compared with controls, may contribute to molecular mechanisms of risk for schizophrenia and bipolar disorder.
The present invention is directed to compositions for noninvasively administering drugs having a sedative, analgesic, or anesthetic effect. A drug capable of absorption through mucosal tissues is incorporated into a candy matrix, which is then advantageously formed into a lollipop. A patient is put at ease when given the lollipop, and the drug rapidly enters the patient's bloodstream as the lollipop is sucked. When sedating or anesthetizing the patient, the physician can observe the patient's condition and remove the lollipop when it has had a desired effect on the patient. Alternatively, the physician can alter placement of the lollipop to slow the rate of the drug release for absorption into the patient's system. An analgesic-containing lollipop can be self-administered by a patient in response to his own subjective experience of pain and to the patient's susceptibility to the particular drug utilized.
The invention relates to a medicine capable of supporting healthy energy and eliminating toxin, and aims to provide a medicine capable of supporting healthy energy and eliminating toxin for livestock and fowl. The medicine has favorable heat relieving action. The medicine is prepared from the following components in parts by weight: 60 parts of radix isatidis, 60 parts of radix astragali, 30 parts of epimedium and 10-16 parts of rhubarb. The formula is improved: the conventional rhubarb for purging intense heat and eliminating toxin is added; and the medicine can not cause diarrhoea of animals, but has obvious curative effect on fever symptoms of the animals. The medicine ensures the organism energy and activity of the animals, can obviously enhance the antiviral capacity by using the compound drugs with immunity enhancing action, and obviously lowers the virus disease infection rate of livestock and fowl. The medicine maintains the favorable growth trend of the animals. The ultramicropowder agent is preferably a specific dispersing agent, thereby obviously prolonging the stable period of the product, preventing moisture absorption and lumping, prolonging the shelf life of the medicine, lowering the medicine cost and avoiding waste of resources.
Patients receive etanidazole derivative EF5 IV over 1-2 hours. Approximately 48 hours after EF5 administration, patients with intraperitoneal tumors undergo surgical resection. Patients with pleural tumors undergo surgical resection approximately 24 hours after EF5 administration. Tumors are then analyzed for EF5 binding and microvascular density by immunohistochemistry and fluorescent antibody techniques.
Subject allocation sequence 1. Intervention : the subject will receive the five products (tested product n°1, tested product n°2, tested product n°3, tested product n°4 and tested product n°5) in a certain order of assignment of each study product (which will be randomly attributed to him via the randomization sequence).