anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Low back pain (LBP) has been associated with education in previous observational studies, but the causality remains unclear. This study aims to assess the impact of education on LBP and to explore mediation by multiple lifestyle factors.
DESIGN: Univariable Mendelian randomization (MR) was performed to examine the overall effect of education on LBP. Subsequently, multivariable MR was conducted to assess both the direct effect of education on LBP and the influence of potential mediators. Indirect effects were estimated using either the coefficient product method or the difference method, and the proportion of mediation was calculated by dividing the indirect effect by the total effect. The observational study utilized data from the NHANES database collected between 1999 and 2004, and included 15,580 participants aged 20 years and above.
RESULTS: Increasing education by 4.2 years leads to a 48% reduction in the risk of LBP (OR=0.52; 95% CI: 0.46 to 0.59). Compared to individuals with less than a high school education, those with education beyond high school have a 28% lower risk of LBP (OR=0.72; 95% CI: 0.63 to 0.83). In the MR study, smoking accounts for 12.8% (95% CI: 1.04% to 20.8%) of the total effect, while BMI accounts for 5.9% (95% CI: 2.99% to 8.55%). The combined mediation effect of smoking and BMI is 27.6% (95% CI: 23.99% to 32.7%). In the NHANES study, only smoking exhibits a mediating effect, accounting for 34.3% (95% CI: 21.07% to 41.65%) of the effect, while BMI does not demonstrate a mediating role.
CONCLUSIONS: Higher levels of education provide a protective effect against the risk of LBP. Additionally, implementing interventions to reduce smoking and promote weight loss among individuals with lower levels of education can also decrease this risk.
BACKGROUND: Though next-generation sequencing (NGS) tests like exome sequencing (ES), genome sequencing (GS), and panels derived from exome and genome data (EGBP) are effective for rare diseases, the ideal diagnostic approach is debated. Limited research has explored reanalyzing raw ES and GS data post-negative EGBP results for diagnostics.
RESULTS: We analyzed complete ES/GS raw sequencing data from Mayo Clinic's Program for Rare and Undiagnosed Diseases (PRaUD) patients to assess whether supplementary findings could augment diagnostic yield. ES data from 80 patients (59 adults) and GS data from 20 patients (10 adults), averaging 43 years in age, were analyzed. Most patients had renal (n=44) and auto-inflammatory (n=29) phenotypes. Ninety-six cases had negative findings and in four cases additional genetic variants were found, including a variant related to a recently described disease (RRAGD-related hypomagnesemia), a variant missed due to discordant inheritance pattern (COL4A3), a variant with high allelic frequency (NPHS2) in the general population, and a variant associated with an initially untargeted phenotype (HNF1A).
CONCLUSION: ES and GS show diagnostic yields comparable to EGBP for single-system diseases. However, EGBP's limitations in detecting new disease-associated genes underscore the necessity for periodic updates.
The invention discloses a near-infrared long-afterglow material with the dual functions of bioimaging and photo-thermal treating. A base material includes La3Ga5GeO14 and Ca3Ga2Ge3O12 or Zn3Ga2Ge2O10. Cr3+ and lanthanide ions are doped in the base material. The lanthanide ions are Nd3+ or Tm3+. The invention further discloses a preparation method of the near-infrared long-afterglow material. According to the near-infrared long-afterglow material, near-infrared long afterglow can be stably emitted, when 808nm lasers harmless to the normal cells of a human body are used for irradiating the long-afterglow material, the long-afterglow material absorbs energy of the lasers, the energy of the lasers is converted into heat, temperature rises fast, and cancer cells combined with the normal cells are killed. In the process, the trend of the long-afterglow material can be detected through a near-infrared probe in the whole process, and visual treatment can be achieved.
The investigators are conducting a pilot randomized clinical trial to test a brief parent-adolescent dating violence prevention intervention (Engaging Together for Healthy Relationships; ETHR). ETHR has been developed for parents and adolescents, to be implemented within pediatric primary care settings. ETHR is a comprehensive intervention which includes a training for clinicians, brief educational scripts for providers, resource guides for the adolescent, parent, and dyad, a comprehensive website, and warm referral processes to connect families with local resources. The investigators will be comparing ETHR with routine care. The specific goal of the pilot trial is to test trial feasibility, as well as intervention acceptability and fidelity. The investigators also will be examining exploratory changes in secondary outcomes and early implementation barriers and facilitators.

Four pediatric clinics will participate in this study. The investigator will recruit two providers from each clinic and randomize them into the intervention provider or control provider. The intervention provider will receive ETHR and the control provider will complete their regular well-child care. The investigators will enroll 15 families in the intervention arm and 5 in the control arm (3:1 enrollment). Families who are seeing the intervention provider for a well-child visit will be enrolled in the intervention arm; those seeing the control provider will be enrolled in the control arm. Families will be eligible if they are seeing the intervention or control providers for a well child visit, if the adolescent coming for the well-visit is between 11 to 15, if both the caregiver and adolescent are interested in participating, and if the family speaks and understands English. Families will be called 2 weeks ahead of their visit to enroll, consent, and complete a baseline survey (both the adolescent and parent will complete the survey). Participants will then attend their well -visit (where they will receive ETHR or routine care, depending on their provider). They will complete an acceptability and fidelity survey immediately post-visit, a resource utilization survey 1 month post visit, and a follow up survey (identical to the baseline survey) 3 months post visit. Providers will complete a brief fidelity and acceptability survey after each study visit (15 for intervention providers, 5 for control providers). All providers and a subset of families enrolled in the intervention arm (20 dyads, 40 participants) will also complete post-intervention interviews.
The invention discloses a heat-resistant glucose oxidase mutant with high antibacterial property and application thereof, and belongs to the field of genetic engineering. The amino acid sequence of the glucose oxidase mutant GOX 1-P514K is shown as SEQ ID NO. 2. The invention takes glucose oxidase GOX1 from aspergillus as a female parent, and mutates the 514 th site of a sequence shown as SEQ ID NO.1 from proline (Pro) to lysine (Lys) in a site-directed mutation mode to obtain a high specific activity heat-resistant mutant GOX 1-P514K. The mutant is obviously superior to the wild glucose oxidase GOX1 in terms of catalytic activity and thermal stability. Meanwhile, the mutant has high specific activity and strong antibacterial property, and has a huge application prospect.
PROBLEM TO BE SOLVED: To obtain a cosmetic composition useful for, the local treatments of wrinkles, dried skins, aged skins, dermatoses (e.g. psoriasis), etc., by combining a specific ester and an essential ingredient in an effective amount with an excipient. SOLUTION: This cosmetic composition contains trichorin tosylate of formula I (R is a choline molecule of formula II) in an amount of 0.0001-50wt.%, and a cosmetically acceptable excipient. The amount of the trichorin tosylate of formula I is especially preferably 0.01-10wt.%. The addition of an alpha-hydroxy carboxylic acid to the system in an amount of 0.01-20wt.%, especially 0.05-10wt.%, is preferable. The composition can enhance the proliferation of keratinocyte in skin, especially enhance the level of phospholipid in the keratinocyte of the skin. The composition is especially useful for treating wrinkles, dryness and ageing of skins, flaky skins, and the appearances of skins demaged with light.
After completion or early withdraw from the treatment protocol, patients will be enrolled into this long-term follow-up study. If patients do not enter this study right after leaving the treatment protocol, they may have the option to enter this study at any time within 15 years after the last lentiviral-based gene-edited immune cell infusion.
PURPOSE:To improve the light stability of the title compd. by substituting an interlayer cation in a clay mineral having cation exchangeability for specified org. dye and a metal cation. CONSTITUTION:The colored lamellar compd. is obtained by substituting the interlayer cation in the clay mineral consisting essentially of a lamellar compd. having cation exchangeability for a cationic or anionic org. dye and the metal cation such as Fe<3+> and Ti<4+>. The colored lamellar compd. colors brightly and stably, and is useful as the colorant having light resistance. The clay mineral consisting essentially of a lamellar compd. having cation exchangeability is dissolved in a polar solvent, and the soln. of a cationic or anionic org. dye and the soln. of the metal ions such as Fe<3+> or Ti<4+> are added to the mixture to obtain the colored lamellar compd. An interlayer cation is the exchanged, and the compd. is separated from the soln. and dried.
Countless efforts have been made to eradicate cervical cancer worldwide, including improving disease screening and human papillomavirus (HPV) vaccination programs. Nevertheless, cervical cancer still claims the lives of more than 300 000 women every year. Persistent infections with high-risk HPV genotypes 16 and 18 are the main cause of cancer and may result in HPV integration into the host genome. The central dogma is that HPV integration is an important step in oncogenesis, but in fact, it impedes the virus from replicating and spreading. HPV causing cervical cancer can therefore be perceived as a failed evolutionary viral trait. Here we outline the occurrence and mechanisms of HPV integration and how this process results in oncogenic transformation.
PROBLEM TO BE SOLVED: To obtain the subject new compound excellent in biodegradability. SOLUTION: This compound is shown by formula I [(m) is 2-10; (n+1) is 8-20; X is at least one of H ion, monovalent and divalent alkali metal ions, alkaline earth metal ions, ammonium ion and organic ammonium ions, e.g. a diacylated product of [S, S] ethylenediaminedisuccinic acid. The compound of formula I is obtained, as a compound of formula III when X=H, by adding to and dissolving in a mixed solvent of water and acetone a diamine of formula II and sodium hydroxide at four equivalent times the diamine, adding an acid chloride at two equivalent times to the diamine dropwise under stirring at 10-60 deg.C for reaction. The compound of formula I is significantly excellent in biodegradability and can be used e.g. as one of various cleansing agents for the skin, hair, tableware, clothing items and so on and as an emulsifier for cosmetics for the skin and hair.  In these cases, this compound is pref. compounded at 0.1-80 wt.%.
Negative pressure aspiration suction is a medical procedure that uses suction to remove fluids, mucus, or other materials from the body by creating a negative pressure or vacuum. The procedure involves inserting a catheter into the airway and applying negative pressure to the catheter to suction out the secretions or fluids. The patient would receive blind negative pressure aspiration suction as the usual medical routine(every 2-4 hrs sputum suction if needed).
Patients receive Gallium Ga 68-DOTA-TOC IV over 1-2 minutes. Within 55-70 minutes, patients then undergo either a PET/CT scan lasting 30-40 minutes or a PET/MRI scan lasting 50 minutes.
The primary objective of this study lies in whether ticagrelor improves endothelial dysfunction compared to clopidogrel, measured by endothelium-dependent flow-mediated dilation (FMD). The secondary objective is to demonstrate whether ticagrelor has an anti-atherosclerotic effect compared to clopidogrel in terms of reducing systemic low-grade inflammation. Endpoints are 1) difference of flow-mediated dilation values, and 2) messenger ribonucleic acid (mRNA) expression measured by quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) of inflammation-associated key genes in circulation monocytes between non-ST-segment acute coronary syndrome patients treated with ticagrelor and clopidogrel.

Patients who agree to participate study are screened at Visit 1 (30 \~ 365 days after index percutaneous coronary intervention). Patients with endothelial dysfunction defined as screening flow-mediated dilation are randomly assigned at Visit 2 (0\~7 days after screening test). And then, patients should receive study drugs according to allocated groups from the day of randomization. Ticagrelor 90mg twice daily or clopidogrel 75mg daily will be maintained for 30 days. Flow-mediated dilation are performed at screening and at Visit 3 (day 30 from the treatment of study drugs) and blood sampling are performed before the first dose of study drugs at Visit 2 and at Visit 3.
An ansamycin all-carbon cycle polyketide-type antibiotic and uses thereof in preparing antimicrobial medications or anti-tumor medications. Verrucosispora sp. SCSIO 07399 preserved on 22 October 2018 at Guangdong Microbial Culture Collection Center (GDMCC) having the address of: Guangdong Institute of Microbiology, 100 Xianlie Middle Road, Building 59, 5th floor, Guangzhou, and having the preservation number of GDMCC No. 60466. The fermentation culture of Verrucosispora sp. SCSIO 07399 can make new compounds kendomycins B to D, as shown in formulas (I) to (III). Said three compounds have markable antimicrobial and anti-tumor activities.
1474209 Watch strap connector TEXTRON Inc 22 Nov 1974 [25 July 1974] 50638/74 Heading E2A A component 20 for making an end attachment 14 for watch bands adapted to be mounted between spaced lugs of a wrist watch comprises a generally tubular member 21 formed from a strip of metal and slidably grinding a pair of oppositely spring biassed tubular inserts 32 therewithin, movement of the tubular inserts outwardly of the member 21 being limited by the co-operation of a respective tab 24, 25 of the member with the closed end of an open-ended slot 33 of a respective insert 32. Each insert 32 is formed from a strip of metal and the slot is formed between adjacent ends of the strip. The tabs 24, 25 of the member 21 are formed one on each of the adjacent ends of the strip from which the member 21 is made. A spring 30 is provided for each insert 32, the springs 30 acting against a tab 28 of the member 21. The tab 28 may be interposed between the coils of a single biassing spring. A top shell 40 comprises a generally tubular portion 41 which partly surrounds the member 21 and is partly retained by tabs 43 of the portion 41 co-operating with cut out portions 27A, 27B of the member 21 (Fig. 4, not shown). For further retaining the top shell 40 on the component 20 flanges (47) and tabs 49 are provided. A flange 46 of the top shell 40 is interposed between adjacent links 15 of, the watch band.
Retinoblastoma is the most common intraocular malignant tumor in childhood, with an incidence of about 1/15,000-20,000, accounting for 4% of all childhood cancers. All patients with bilateral reticuloblastoma and approximately 10%-15% of children with unilateral disease have germline mutations that can be passed on to their offspring.In developed countries, the survival rate is close to 98%. However, due to the limitations of health care in low-income countries, this proportion is much lower, about 40%. Before the 1990s, retinoblastoma was mainly treated with enucleation and external beam radiation therapy (EBRT). However, these methods are associated with many complications, including vision loss and serious side effects. At present, the first-line conservative treatment of retinoblastoma has changed from EBRT and enucleation to Intravenous chemotherapy (IVC) or intra-arterial chemotherapy (IAC), and it has been consolidated through focal treatment. There are two different surgical procedures for intra-arterial chemotherapy, namely balloon technique and microcatheter technique. Investigators observe their effects through a retrospective case-control study.
Participants will receive four OMTs at week 1, 2, 4 and 8. Joint mobilization techniques for ribs, cervical and dorsal spine, as well as visceral treatment, soft-tissue release on diaphragm and abdominal wall will be used.
PD-1 monoclonal antibody 200mg is infused intravenously once for patients whose age \>=18 years, or age \<18 years but weight \>=40kg. While for patients age \<18 years, the dose of PD-1 monoclonal antibody is 3mg/kg.
Methods of treating certain behavioral characteristics associated with autis m are provided. Additionally, methods of treating disorders associated with repetitive behaviors, social deficits and/or cognitive deficits are also provided. A therapeutic amount of oxytocin or oxytocin analogs, either alone or in combination, are administered to individuals demonstrating behavioral characteristics associated with autism or other disorders to reduce the severity of the debilitating behavior. In various aspects, characteristics such as deficit in social awareness or cognitive skills and repetitive behaviors are treated. Co-administration of oxytocin and/or oxytocin analogs with known psychopharmacologic agents is also provided. Advantageously, oxytocin and oxytocin analogs do not have deleterious effects with other dru gs such that administration results in few side effects.
The burden of group A streptococcus (GAS) infection and its rheumatic sequelae remains dramatically high, especially in low-income countries. Recently, an increased number of Acute Rheumatic Fever (ARF) cases was documented in many regions of Italy. The diagnosis of rheumatic sequelae relies on clinical signs and on the evaluation of the Antistreptolysin O titre (ASO), whose variations are globally reported. To re-examine the standard reference value of ASO titre, by measuring either its upper limit of normal (ULN) in a population of healthy children (HC) or comparing these values with streptococcal antibodies registered in a cohort of patients affected by the rheumatic sequelae of GAS infection. We performed a multicenter retrospective study. We enrolled 125 HC, aged 2-17 years, and a total of 181 patients affected by ARF, acute streptococcal pharyngitis, post-streptococcal arthritis, Henoch-Schönlein purpura and erythema nodosum, divided into four groups. The levels of ASO and anti-deoxyribonuclease B (anti-DNase B) titres were analyzed and compared among the various groups. Moreover, the 80th percentile value was calculated and established as the ULN for ASO titre in HC group. The ULN for ASO titre in overall HC group was 515 IU/mL, resulting in higher than used in the routine investigation. The ASO titre was significantly higher in patients with rheumatic sequelae compared with HC group, with a peak in the age between 5 and 15 years.    Conclusion: Our study established a new ULN normal value of streptococcal serology in a childhood and adolescent population of Italy, suggesting the need to extend this revaluation to the critical areas, in order to avoid underestimating ARF diagnosis. The correct interpretation of ASO and anti-DNase B values in the context of rheumatic diseases has been discussed. What is Known: • The global burden of disease caused by group A streptococcus is not known and remains an important cause of morbidity and mortality. Acute rheumatic fever continues to be a serious worldwide public health problem and a recent recurrence of group A streptococcus infection cases is observed. • The streptococcal sequelae requires evidence of preceding streptococcal infection, commonly elevated streptococcal antibody titre, but the upper limit for these titres varies considerably based on age group, region, and origin. What is New: • This study provides population-specific values for streptococcal antibody titres in Italy. • Interpret the results of group A streptococcal antibody tests within the clinical context.
Stroke is a common disease among older people. In Norway 60-70 000 people live with sequela after stroke. Depressive symptoms, anxiety and social isolation are occurring among 20 to 60 percent. Little is known about intervention for people with mild neurological symptoms who simultaneously perceive social isolation, depression and reduced satisfaction in their daily life after stroke. Lifestyle redesign (LR) is developed in the USA and is a health promoting group intervention programme with focus on the participants' exchange of experiences and involvement. The aim of the study is to evaluate the effect on thriving, activity and social participation of a group intervention program inspired by Lifestyle redesign for community dwelling persons with stroke. The study is conducted as a multicentre randomized controlled trial. Participants are recruited from five hospitals and the intervention is carried through at six to seven senior centres. The control group is offered a physical activity programme at the senior centre once a week. The intervention group is offered the same with the additional intervention programme also once a week. The study will contribute to knowledge whether this group intervention will promote social participation and thriving in daily life and prevent social isolation and depressive symptoms among community dwelling elders with stroke or TIA.
BACKGROUND: Patients with chronic kidney disease on hemodialysis (HD) often have cognitive deficits. However, there are few studies that have examined the neuropsychological impairments of patients receiving peritoneal dialysis (PD).
METHODS: Executive functions, processing speed and verbal memory were assessed in 27 PD patients, 42 HD patients, and 42 healthy participants (HP). Systolic blood pressure and total time on renal replacement therapy (RRT) were controlled statistically. Associations between performance and clinical factors were analyzed using correlations and multiple regression.
RESULTS: The DP group showed better performance compared to the HD group in verbal fluency, working memory, cognitive flexibility, planning and decision making. The DP group showed worse execution than the HP group in verbal inhibition and memory. Executive function scores were positively associated with total months on PD, total months on RRT, total months on HD, albumin, total cholesterol, and phosphorus, and negatively with ferritin.
CONCLUSION: Global executive functioning was more optimal in PD patients than in HD patients. The results show the positive effect of PD on executive functions, which must be taken into account when choosing the TRS. The associations observed between biochemical factors and performance show the importance of maintaining an adequate nutritional status in these patients.
Participants in this group will receive an 8-week in-person group exercise program held twice weekly, in which they will receive exercise instructions (60 minutes) and standard osteoarthritis (OA) education (15 to 20 minutes/week for the first 4 weeks). A third home session (weekly) will be facilitated by exercise handout sheets. The exercise component (i.e., the specific movements) of this group will be similar to those of the other group without the added techniques of breath awareness and regulation, muscle tension regulation, awareness of pain related thoughts and emotions, relaxation, and body awareness. The standard OA education videos will cover the following topics: common OA symptoms, risk factors associated with knee OA, and the effects of exercise and self-management tips. The exercise and education components will be delivered by a physiotherapist in the research team.