anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This multicenter, intra-subject controlled, open-label, active-treatment study will assess in children affected by Secondary Hyperparathyroidism, aged 2-18 years on chronic dialysis not responsive to standard of care (SoC) therapy, the response after 6-month cinacalcet compared intra-subject to SoC alone at screening visit 6 months prior to cinacalcet start. Secondary objectives are to evaluate effects on growth over 18 months and PK profile. At baseline children have PTH levels\>300 pg/mL, plasma P\<6 mg/dL, and Ca 8.4-10.5 mg/dL, or Ca x P product\>60 not responsive to SoC. Initial dosing of cinacalcet will be 0.5-0.75 mg/Kg per os OD to be adjusted up to a max of 180mg OD for target PTH values\<180 pg/mL in absence of hypocalcemia. Thirty children will be enrolled at 12 centres participating in a national paediatric dialysis registry, corresponding to an α=0.05 and a power of 80% using the McNemar test, with an expected % of responders to cinacalcet or SoC of 40% or 5% respectively, with a drop-out rate of 15. Primary study endpoint (EP) will be the % of children who will have a reduction from baseline \>25% in mean PTH levels during the 6-mo efficacy-assessment period. Among secondary EPs over 18 mos will be the % of patients with mean PTH levels\<300 pg/mL; the % change in PTH, Ca, P values, and the Ca x P product; PK profile (or population profile by age) and its correlation with PTH and testosterone levels; auxological indices and growth velocity; % of children with treatment-emergent adverse events and lab abnormalities; retention on treatment and reasons of treatment withdrawal. The study will evaluate whether cinacalcet represents a safe and effective therapeutic option for SHPT children.
A cross-sectional study, enrolled 607 Saudi patients, of both sexes, registered for Ha'il University Medical Polyclinic, Ha'il city, Saudi Arabia, from October 6, 2020 to January 31, 2021. Patients eligible for inclusion in this study included those who were aged 18 years or older and were diagnosed with hypertension. Hypertension is defined as a systolic blood pressure (SBP) of 140 mm Hg or more, or a diastolic blood pressure (DBP) of 90 mm Hg or more, or taking antihypertensive medication or a positive self-reported history of hypertension (based on a response to the questions "have you ever been told you have high blood pressure" or "a past history of high blood pressure").\[13\] Exclusion criteria included pregnant or breastfeeding females; history of nephrotoxic drugs use and any case with known cause of CKD other than hypertension such as diabetes mellitus, polycystic kidney disease, obstructive uropathy or autoimmune diseases. Among 607 hypertensive patients who underwent health examinations, 175 patients met the exclusion criteria and were removed from the study. We also removed 40 patients from the remaining 432 individuals due to missing data, leaving 392 patients for analysis.Minimum sample required for this study was calculated using the formula: n = z2 \[P (1 - P)/(D2)\], confidence level at 95 % (z = 1.96), margin of error (D) is set at 0.05, and (P) is the prevalence of hypertension in adult Saudi population set as 25.5 %. (n = 292). Data was collected through an interview questionnaire. The questionnaire included sociodemographic variables (age, sex, height, weight, BMI and smoking habit), hypertension (duration and drugs taken), as well as other chronic comorbidities in addition to previous family history of renal diseases. This is in addition to the laboratory investigations and radiological reports collected from the participants during the interview.
Periodontitis is a chronic inflammatory disease mainly caused by the oral microbial biofilm. It involves the periodontal supporting tissues mainly features gum inflammation, alveolar bone resorption, periodontal pocket formation, and tooth loosening but also induces various systemic diseases, which seriously affect the physical and mental health of patients. The response to periodontal infection is mediated by various intracellular signaling pathways leading to the production of numerous bio-molecules. Vitronectin is a multifunctional protein with multiple binding domains that interact with a variety of plasma and cell proteins. It belongs to the group of adhesive glycoproteins that are involved in various functions including complement activation, blood coagulation, binding to proteoglycans, and modification of the matrix. Among the various cystatins expressed in serum and saliva, Fetuin-A, another protein is produced majorly by healthy hepatic and adipose tissues. Fetuin-A has been recognized as a multifunctional molecule related to its role in metabolic processes, insulin resistance, regulation of adipogenesis, and mineralization throughout the body. To find out the effect of non-surgical therapy on the periodontal and cardiac parameters and the salivary levels of Vitronectin and Fetuin-A in patients with periodontitis (stage II-III) and coronary artery disease.
The present disclosure generally relates to systems and methods for treating vitiligo. In one set of embodiments, the present disclosure comprises a composition comprising ethyl pyruvate. The composition may be formulated for application to the skin of a subject, for instance, as a gel, lotion, cream, ointment, soap, or stick. In some cases, the composition may comprise a lecithin, such as phosphatidylcholine. In certain embodiments, the lecithin is present as a liquid crystal, and/or in liposomes, micelles, or other vesicles. Other aspects of the present disclosure are generally directed to methods of making or using such compositions, methods of promoting such compositions, kits including such compositions, or the like.
Several reports assume that myocardial necroptotic cell death is induced during the development of chronic heart failure. Although it is well accepted that angiotensin II induces apoptotic cell death of cardiac myocytes, the involvement of angiotensin II in the induction of myocardial necroptosis during the development of heart failure is still unknown. Therefore, we examined the role of angiotensin II in myocardial necroptosis using rat failing hearts following myocardial infarction and cultured cardiomyocytes. We found that administration of azilsartan, an angiotensin II AT1 receptor blocker, or trandolapril, an angiotensin-converting enzyme inhibitor, to rats from the 2nd to the 8th week after myocardial infarction resulted in preservation of cardiac function and attenuation of mixed lineage kinase domain-like (MLKL) activation. Furthermore, the ratio of necroptotic cell death was increased in neonatal rat ventricular cardiomyocytes cultured with conditioned medium from rat cardiac fibroblasts in the presence of angiotensin II. This increase in necroptotic cells was attenuated by pretreatment with azilsartan. Furthermore, activated MLKL was increased in cardiomyocytes cultured in conditioned medium. Pretreatment with azilsartan also prevented the conditioned medium-induced increase in activated MLKL. These results suggest that angiotensin II contributes to the induction of myocardial necroptosis during the development of heart failure.
PURPOSE:To provide the titled agent capable of lowering or eliminating the mutagenicity of food, table luxuries, etc., and composed of an embryo preparation such as malt, soybean, rice bran, and their extracted fractions, etc. CONSTITUTION:An antimutagenic agent is obtained by using an embryo preparation selected from the group of malt, soybean, rice bran, and their extracted fractions, as a component. The mutagens proved to be existent in foods and table luxuries are e.g. benzo[a]pyrene, aflatoxin B1, 2-aminofluorene, benz[a] anthracene, etc. In the usual foods and drinks, the level of mutagenicity is high in coffee. The above embryo preparation inactivates the mutagenicity in black tea and straight bourbon as well as coffee. The necessary amount of the preparation is 0.25-25mg of the malt powder, soybean flour or rice bran, or 0.05-0.5mg of the dried powder of said extracted fraction based on the normal concentration of coffee (5-20mg of coffee powder per 1 liter).
The invention relates to a Prodrug activation method, for therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention also relates to a Prodrug kit comprising at least one Prodrug and at least one Activator, wherein the Prodrug comprises a Drug and a first Bio-orthogonal Reactive Group (the Trigger), and wherein the Activator comprises a second Bio-orthogonal Reactive Group. The activator may be a diene according to formula (4): (4). The trigger may comprise a dienophile comprising a structure according to formula (la): (la). The invention also relates to targeted therapeutics used in the above-mentioned method and kit. The invention particularly pertains to antibody-drug conjugates and to bi-and trispecific antibody derivatives.
PURPOSE: A paramagnetic hetero-polymetallic complex with enhanced relaxivity and thermodynamic stability is provided to apply as contrast agent of MRI. CONSTITUTION: A compound is denoted by chemical formula 1. A gadolinium complex of the compound is denoted by chemical formula 2. A paramagnetic hetero-polymetallic complex is denoted by chemical formula 3. The paramagnetic metal is sodium, potassium, magnesium, calcium, copper, or zinc. A method for preparing the compound of chemical formula 1 comprises: a step of adding histidine or aspartic acid to DTPA-bis-anhydride and stirring; a step of removing a solvent and adding methanol to the mixture; a step of performing silica gel chromatography; a step of precipitating in acetone; and a step of drying under vacuum condition. A contrast agent contains gadolinium complex of chemical formula 2.
The research was carried out at the Emergency Department of the Etimesgut Şehit Sait Ertürk State Hospital in Ankara from April 2021 to February 2022. The sample of the study consisted of 126 adult patients. The patients were divided into three groups by randomization method. VRG was applied to the first group, Buzzy to the second group and the control group which was the third group using the standard procedure. Before the procedure of PIC, "Introductory Characteristics Form for Patients" was prepared by the researcher containing the sociodemographic characteristics of the participants (gender, marital status, age, educational status, etc. as such). This form was filled out by asking the patient by face-to-face interview method. After catheterization, the "Visual Comparison Scale for Pain" was used by the nurse practitioner to determine the pain of the patients and the "Visual Comparison Scale for Satisfaction" was used to determine the satisfaction status of the patients regarding the application to be performed. It is expected that pain and patient satisfaction scores in groups where a VRG and Buzzy® were used during PIC in adult patients will result more positively than in the control group. It is thought that the results obtained from the research will contribute to the literature.
The present invention relates to external-use medicinal powder for treating piles, which is characterized in that the external-use medicinal powder is composed of 14 to 17 of Chinese gall, 6 to 9 of dried alum, 10 to 13 of catechu, 6 to 8 of cicada slough, 14 to 18 of cochinchina momordica fruit, 4 to 6 of borneol, 8 to 10 of rhubarb, 8 to 10 of cattail pollen, 0.5 to 1.5 of dyclonine, 6.5 to 10 of mirabilite, and 7 to 10.5 of frankincense. The medicinal has the functions of relieving inflammation, resisting bacteria, expelling stasis, dispersing the accumulation of pathogen, dispersing swelling, relieving pain, killing bacteria, relieving itch, promoting wound healing, stopping bleeding, removing toxicity, promoting muscle granulation, eliminating dampness, relieving desertion, etc. to improve blood circulation of nidus tissue and restore the normal structure and functions of histiocytes. Observed for several years in clinic, the medicinal powder has good curative effects on swelling and pain caused by piles, prolapse, anal fissure, anal sinusitis, anal infections, etc. and has the advantages of convenient operation and no toxic or side effect; after being treated, patients do not have sequelaes such as anal stenosis, fecal incontinence, etc. and are not limited by contraindication; the medicinal powder is capable of being used as a normal standby medicine, conforms to the requirements of simplicity, convenience, low cost and practicality; the medicinal powder is deeply trusted, welcomed and favored by the patients.
Patients will be instructed to brush twice daily. Patients will be instructed to apply at least a 1-inch strip of the Placebo formulation toothpaste onto a soft toothbrush and to brush thoroughly for 2 minutes and expectorate. All patients will be instructed to use only the assigned products and refrain from other dentifrice or mouth-rinse during the trial but will be allowed to continue their normal oral hygiene practices. Patients will use the assigned product for a period of 24 weeks for assessment of the efficacy and safety in periodontitis patients.
BACKGROUND: Anastomotic leak is one of the most feared complications of esophagectomy. Previous studies have suggested a potential link between aortic calcifications detected on routine preoperative CT scans and increased risk of anastomotic leak after esophagectomy. This study aims to investigate whether clinicians' assessment of aortic calcifications can predict the occurrence of anastomotic leaks in patients undergoing esophagectomy for cancer.
METHODS: A long-term follow-up was conducted on consecutive patients with esophageal cancer who underwent elective open esophagectomy at a Finnish tertiary hospital. Aortic calcifications were evaluated based on CT scans and categorized on a 0-3 scale reflecting the number of calcifications in the affected segment of the aorta. Reviewers assessing the calcifications were blinded to clinical details and postoperative outcomes.
RESULTS: The study included 97 patients (median age: 64 years and range: 43-78; 20% female), with a median follow-up time of 1307 (2-1540) days. Among them, 22 patients (23%) had postoperative anastomotic leak. We observed a significant association between calcifications in the descending aorta and a higher risk of anastomotic leak (p = 0.007), as well as an earlier occurrence of leak postoperatively (p = 0.013). However, there was no association between aortic calcifications and increased mortality.
CONCLUSIONS: Presence of calcifications in the descending aorta is independently associated with an increased risk of anastomotic leaks following esophagectomy for cancer. Identifying patients at higher risk for this complication could facilitate appropriate pre- and postoperative interventions, as well as enable earlier diagnosis and treatment to mitigate the severity of the complication.
Exhaustive efforts have been dedicated to uncovering genomic aberrations linked to cancer susceptibility. Noncoding sequence variants and epigenetic alterations significantly influence gene regulation and could contribute to cancer development. However, exploring noncoding regions in hereditary cancer susceptibility demands cutting-edge methodologies for functionally characterizing genomic discoveries. Additionally, comprehending the impact on cancer development of variants in noncoding DNA and the epigenome necessitates integrating diverse data through bioinformatic analyses. As novel technologies and analytical methods continue to advance, this realm of research is rapidly gaining traction. Within this mini-review, we delve into future research domains concerning aberrations in noncoding DNA regions, such as pseudoexons, promoter variants and cis-epimutations.
Insulin preparations for percutaneous administration are made up with an ointment or plaster base consisting of a fat or oil which is substantially free from cholesterine, phytosterine or other sterines. Preferably the pH of the preparations is adjusted to about 3 or to between 7 and 8, for instance by addition of weak organic acids, such as nitric acid, or their salts.  Fats and oils stated to be suitable are lard, vaseline, olive oil, castor oil and palm nut oil.  When using such fats or oils samples are chosen which are substantially free from sterines, or the sterines may be removed by suitable treatment (not specified).  According to examples insulin is triturated with lard used alone or containing small quantities of nitric acid or sodium citrate in solution. Wool fat, eucerin, rape seed oil, linseed oil and ground nut oil are stated to be unsuitable bases.
Patients in the ET@Home study condition will receive four modules of video and print transplant education over a 6-month period. After each module is mailed, 3 postcards are mailed weekly that recap important transplant educational content covered within the videos. Patients will have the opportunity to participate in a texting component of ET@Home that also sends small pieces of educational content and learning reminders by phone each week.
The invention relates to a traditional Chinese medicine composition for treating kidney stones. The composition is prepared from the following components in parts by weight: 45 to 55 parts of pyrrosia lingua, 8 to 12 parts of mirabilite, 13 to 17 parts of bryozoatum, 18 to 22 parts of semen vaccariae, 27 to 33 parts of lysimachia christinae hance, 14 to 16 parts of spora lygodii, 13 to 17 parts of gizzard pepsin, 13 to 17 parts of radix curcumae, 18 to 22 parts of eucommia ulmoides, 27 to 33 parts of medicated leaven, 13 to 17 parts of immature bitter orange, 18 to 22 parts of semen plantaginis, 18 to 22 parts of lalang grass rhizome and 13 to 17 parts of white paeony root. The composition pays equal attention to disease and syndrome differentiation and has the effects of tonifying the kidney and smoothing urination simultaneously so as to treat both symptoms and root causes. The composition has the functions of clearing heat, treating stranguria and removing urinary stones as well as invigorating the circulation of blood and tonifying the kidney under the combined actions of all the medicine components. The composition has the obvious effect and the low recurrence rate. Thus, the composition provided by the invention is a compound traditional Chinese medicine preparation which is capable of treating both symptoms and root causes and has a good application prospect.
After the 5-minute warm-up at 30% peak watts, HIIT will consist of repeated 1-minute, high intensity bursts ("on" interval) alternated with 1-minute interval recovery ("off" interval) for 25 minutes. The "on" interval will begin at 70% of peak watts (range: 65%-95%) followed by the "off" interval at 10% of peak watts. The average HR for the "on" intervals will not exceed 85% age predicted maximum (75-85%). There will be 13 minutes of "on" and 12 minutes of "off" interval exercise. An active cool-down (20% peak workload) at comfortable stepping pace occurs immediately after the intervention.
OBJECTIVE: This study aims to construct and evaluate an individualized nomogram for predicting the risk of lower limb lymphedema after cervical cancer surgery. Healthcare professionals can utilize line chart models to predict the probability of postoperative lower limb lymphedema in different patients, allowing for the early identification of high-risk patients and facilitating early prevention and treatment.
METHODS: A retrospective study was conducted among 411 cervical cancer patients treated at our hospital from May 2021 to December 2023. The patients were randomly divided into a modeling group (313 cases) and a validation group (98 cases) according to an approximate 3:1 ratio. The modeling group was further divided into a lower limb lymphedema group (61 cases) and a non-lower limb lymphedema group (252 cases) based on the presence of postoperative lower limb lymphedema. Multiple factors Logistic regression was used to identify risk factors, and a nomogram was constructed using R software version 4.0.2, with internal and external validation performed.
RESULTS: Risk factors for lower limb lymphedema following cervical cancer surgery include age 60 years or older, a Body Mass Index (BMI) of 24 kg/m² or higher, hypertension, the removal of 30 or more lymph nodes, adjuvant radiotherapy and chemotherapy, and prolonged standing for six hours or more (P < 0.05). Internal and external validation results demonstrated that the calibration curve closely aligned with the ideal curve. The Area Under Curve(AUC) of the Receiver Operating Characteristic(ROC) curve was 0.890 (95% CI: 0.844 ∼ 0.936) and 0.876 (95% CI: 0.821 ∼ 0.930), indicating high model calibration and discrimination. Decision Curve Analysis(DCA) curve revealed that the Logistic model had good net returns and high clinical practicality when the probability range of the high-risk threshold was 0.11 ∼ 0.98.
CONCLUSION: The nomogram, developed using factors such as age, BMI, hypertension, number of lymph nodes dissected, adjuvant radiotherapy and chemotherapy, and duration of standing, has strong predictive value and offers significant clinical benefits, making it a valuable tool for clinical decision-making.
Disclosed is a bath bomb having a double layer structure including a core portion formed in a solid phase and an outer skin portion formed in a solid phase and surrounding the core portion. In the bath bomb of the present invention, the outer skin portion comprises a mixture of carbonate powder and organic acid powder, when the bath bomb is input into water in a bathtub, carbon dioxide is generated by the carbonate powder in the outer skin portion. In addition, the core portion contains a surfactant component, and the outer skin portion is dissolved and lost in the water of the bathtub due to the carbon dioxide production reaction. Therefore, when the core portion is exposed, foam is generated by the surfactant component in the core portion. The bath bomb having a double layer structure according to the present invention allows a foaming process by carbonate and a foam generating process by the surfactant to be performed step by step, such that a bather can get visual fun and enjoyment. In addition, the bather can select the amount of foam generated, thereby further improving user satisfaction. In addition, the bath bomb of the present invention can be easily formulated into a desired shape by separating vegetable oil or an extract component and the surfactant component.
The invention belongs to the field of antitumor drugs, and discloses preparation and application of a dual-curative-effect antitumor drug based on nanocellulose-loaded nanogold and curcumin. The drug carrier of the invention adopts nanocellulose, and after proper treatment, gold nanoparticles and cyclodextrin are loaded on the carrier, and the cyclodextrin is used for containing the antitumor drug. The problem that the existing natural antitumor drugs are indissolvable is solved. The AuNP loaded on the nanoparticles achieves a hyperthermia effect under near infrared irradiation, and the thermal effect promotes curcumin heat release, thereby enhancing the efficacy of chemotherapy. The heat resistance and the stability of the antitumor drug curcumin are obviously improved, which is beneficial to pretreatment and also beneficial to improving the bioavailability of the curcumin. The water solubility of curcumin is obviously improved, and compared with the natural solubility of curcumin, the curcumin is improved by nearly 150 times and reaches 131.7 mug/mL. It is expected that the dual therapeutic antitumor drug will become a powerful candidate for tumor treatment.