anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The prognosis of acute kidney injury (AKI) is markedly worse in patients with diabetes. Diabetes not only exaggerates the severity of AKI but also prevent kidney repair or recovery from AKI. Little is known about the cellular and molecular basis of defective kidney repair in diabetes. One obstacle in studying kidney repair in diabetes is the lack of suitable animal models. Specifically, diabetes increases AKI severity, making it difficult to induce the same level of AKI in diabetic and nondiabetic animals to compare their kidney repair. Here, we have identified a time window of 4 days immediately after the completion of streptozotocin (STZ) treatment in mice when blood glucose has yet to rise. Within this time window, renal ischemia-reperfusion injury (IRI) induced the same level of AKI in STZ-treated mice [127.2 ± 12.82 mg/dL blood urea nitrogen (BUN), 2.275 ± 0.4728 serum creatinine] and vehicle solution-treated mice (128.6 ± 11.83 mg/dL BUN, 2.087 ± 0.4748 mg/dL serum creatinine]. By days 5-6, the post-AKI kidney entered into the phase of kidney repair when diabetic hyperglycemia started in STZ-treated mice, providing the opportunity to study the effect of diabetes on kidney repair without affecting initial AKI. In this model, kidney repair was indeed impaired by diabetes (116.5 ± 8.052 mg/dL BUN and 1.382 ± 0.2732 mg/dL serum creatinine in IR + vehicle group; 136.6 ± 8.740 mg/dL BUN and 1.916 ± 0.3756 mg/dL serum creatinine in IR + STZ group). The impairment was associated with decreased tubular cell proliferation and increased tubular cell senescence, peritubular capillary (PTC) rarefaction, inflammation, and 40.90% more interstitial fibrosis.NEW & NOTEWORTHY Little is known about the cellular and molecular basis of defective kidney repair in diabetes. One obstacle in studying kidney repair in diabetes is the lack of suitable animal models. Here, we report a mouse model to investigate the effect of diabetes on kidney repair without affecting initial injury and found that the repair defect is associated with decreased renal tubular cell proliferation and increased tubular cell senescence, PTC rarefaction, inflammation, and interstitial fibrosis.
<P>PROBLEM TO BE SOLVED: To provide an improved pharmaceutical composition for treating or preventing the damage of epithelial tissues, and to provide an improved method for the treatment and prevention.  <P>SOLUTION: This pharmaceutical composition for repair of epithelial tissues comprising a first polypeptide having the biological activity of a platelet-derived growth factor (PDGF) and a second polypeptide having the biological activity of keratinocyte growth factor (KGF). The pharmaceutical composition for repair of epithelial tissues, wherein the first polypeptide comprises a full-length PDGF polypeptide. The pharmaceutical composition, wherein the first polypeptide comprises a biologically active fragment of a full-length PDGF polypeptide. The pharmaceutical composition, wherein the first polypeptide comprises one selected from the group consisting of PDGF A chain and PDGF B chain.  <P>COPYRIGHT: (C)2007,JPO&INPIT
Strong CYP3A4 inhibitors: Simvastatin, like several other inhibitors of HMG-CoA reductase, is a substrate of CYP3A4. Simvastatin is metabolized by CYP3A4 but has no CYP3A4 inhibitory activity; therefore it is not expected to affect the plasma concentrations of other drugs metabolized by CYP3A4.

Elevated plasma levels of HMG-CoA reductase inhibitory activity increases the risk of myopathy and rhabdomyolysis, particularly with higher doses of simvastatin [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.3)]. Concomitant use of drugs labeled as having a strong inhibitory effect on CYP3A4 is contraindicated [see Contraindications (4)]. If treatment with itraconazole, ketoconazole, posaconazole, voriconazole, erythromycin, clarithromycin or telithromycin is unavoidable, therapy with simvastatin must be suspended during the course of treatment.

Cyclosporine or Danazol: The risk of myopathy, including rhabdomyolysis is increased by concomitant administration of cyclosporine or danazol. Therefore, concomitant use of these drugs is contraindicated [see Contraindications (4), Warnings and Precautions (5.1) and Clinical Pharmacology (12.3)].
FIELD: drugs. SUBSTANCE: chloroform is placed into flask and brilliant green is dissolved in it. Then cross-linking food concentrate is poured into the other flask and potassium iodide and furazolidone were dissolved in it. Then the content of the first flask is added to the content of the second flask and total volume is brought about to 1.0 l by addition of cross-linking food concentrate. Prepared suspension is stirred, packaged, frozen and lyophilized. Preparation has the following composition, wt.-%: furazolidone 1.0-1.5; brilliant green 0.3-0.5; potassium iodide 2.5-3.0; chloroform 1.5-2.0, and cross-linking food concentrate - the rest. EFFECT: enhanced therapeutic effectiveness and stability at storage. 2 tbl
Alzheimer's Disease is a type of dementia that causes progressive deterioration to memory, thinking and behaviour. It is currently thought to affect 50 million people globally, although 75% of those affected are thought to be undiagnosed, with no access to treatment.\[2\] Diagnosis requires extensive clinical evaluation, involving a range of techniques that are resource-intensive and can only be performed in clinical settings. Research has demonstrated a direct link between carefully designed spatial learning within computer games and the detection of deterioration in specific brain cells first affected by Alzheimer's Disease, overlooked by existing assessment techniques. This research will look at the feasibility of using a computer game diagnostic tool, called G:DATA, in the diagnosis of Alzheimer's Disease. It will do this by providing a clinical benchmark, consolidating the results of gameplay performance against current clinical gold-standard assessments, during a clinical study conducted with two patient groups (patients with Mild Cognitive Impairment (MCI), patients with mild AD-related dementia) and a healthy controls group. Outcomes will include validity data of the game's output in diagnosing Alzheimer's Disease, together with data on the tool's usability, and acceptability.
The present invention provides methods and compositions designed for the treatment, management, and/or amelioration of an infection, in particular an intracellular pathogen infection, such as a viral, bacterial, protozoa or fungal infection. In particular, the present invention provides methods for treating, managing, preventing and/or ameliorating an infection where the expression of EphA2 is upregulated in infected cells (e.g., infected epithelial cells), said methods comprising administering to a subject an effective amount of one or more EphA2/EphrinA1 Modulators. In accordance with the present invention, such methods may also comprise the administration of one or more therapies other than an EphA2/EphrinA1 Modulator. The present invention also provides pharmaceutical compositions comprising EphA2/EphrinA1 Modulators, and optionally, one or more prophylactic or therapeutic agents other than an EphA2/EphrinA1 Modulator, and the use of such compositions in the treating, management, prevention and/or amelioration of an infection. Further provided by the invention are articles of manufacture and kits comprising an EphA2/EphrinA1 Modulator of the invention, and, optionally, other prophylactic or therapeutic agents (e.g., immunomodulatory agents, anti-viral agents, anti-inflammatory agents, anti-bacterial agents, anti-fungal agents, etc.).
Severe hepatic reactions, including acute liver failure, jaundice, hepatitis and cholestasis, have been reported in postmarketing data in patients receiving REMICADE. Autoimmune hepatitis has been diagnosed in some of these cases. Severe hepatic reactions occurred between 2 weeks to more than 1 year after initiation of REMICADE; elevations in hepatic aminotransferase levels were not noted prior to discovery of the liver injury in many of these cases. Some of these cases were fatal or necessitated liver transplantation. Patients with symptoms or signs of liver dysfunction should be evaluated for evidence of liver injury. If jaundice and/or marked liver enzyme elevations (e.g., ≥5 times the upper limit of normal) develop, REMICADE should be discontinued, and a thorough investigation of the abnormality should be undertaken. In clinical trials, mild or moderate elevations of ALT and AST have been observed in patients receiving REMICADE without progression to severe hepatic injury [see Adverse Reactions (6.1)].
Any pregnant woman, with a singleton pregnancy, giving birth at Saint-Etienne University Hospital, with an indication for induction of labour from 37SA will be included. The indications may be for a maternal pathology, a maternal wish or a foetal pathology.
Cancer-associated fibroblasts (CAFs) play a pivotal role in cancer progression. This study aimed to explore the roles of CAFs-derived Fibroblast growth factor 9 (FGF9) and Neuro-oncological ventral antigen 1 (NOVA1) in triple negative breast cancer (TNBC) progression. MDA-MB-231 and BT-549 cells were cocultured with CAF conditioned-medium (CAF-CM) or normal fibroblasts conditioned-medium (NF-CM). MTT, EdU, colony formation, wound healing, transwell migration, and invasion assays were employed to determine cell proliferation, migration and invasion, respectively. Western blot and RT-qPCR were carried out to examine the protein and mRNA expression of FGF9 and NOVA1. Xenograft tumor experiments were conducted to evaluate the effects of CAFs, FGF9, and NOVA1 on tumor growth in vivo. Our results showed that CAFs significantly promoted the proliferation, invasion, and migration of TNBC cells. FGF9 and NOVA1 were significantly upregulated in TNBC CAFs, tissues and cells. CAF-CM also could increase the expression of FGF9 and NOVA1 in TNBC cells. Knockdown of FGF9 or NOVA1 could hamper cell proliferation, invasion, migration, and EMT of TNBC cells. Moreover, CAFs with FGF9/NOVA1 knockdown also could inhibit TNBC progression. Besides, CAFs significantly accelerated tumor growth in vivo, which was blocked by FGF9/NOVA1 knockdown in nude mice. In conclusion, our results indicated the tumor-promoting role of CAFs in TNBC progression. FGF9 and NOVA1 upregulation in CAFs induced cell proliferation, migration and invasion in vitro, and facilitated tumor growth in vivo in TNBC development.
PURPOSE:To obtain the titled compound useful as antitumor agent, etc., in high purity, by culturing a microbial strain capable of producing polysaccharide NSG-1, incubating the proliferated cell in a liquid containing a carbohydrate to produce polysaccharide NSG-1 and separating the product from the reaction liquid. CONSTITUTION:A microbial strain capable of producing polysaccharide NSG-1 [e.g. Sclerotinia sclerotiorum (IFO 9353), etc.] is cultured in a medium and the obtained primary seed strain is inoculated and cultured in a medium to obtain secondary seed strain. The strain is added to a jar fermenter, cultured in a mass and filtered to obtain cultured cells. The cell is filled together with a liquid containing a carbohydrate such as glucose, etc., into a jar fermenter and incubated. The objective polysaccharide NSG-1 produced in the reaction liquid is separated therefrom.
PURPOSE:The titled stable syrup free of irritant taste obtained by incorporating fenbufen which is an anti-inflammatory and analgesic agent with crystalline cellulose, magnesium aluminate metasilicate and cycloeextrin in a specific proportion and having no irritant taste. CONSTITUTION:A stable fenbufen suspended syrup containing (A) 0.1-5wt./vol% fenbufen [chemical name; 4-(4-biphenylyol)-4-oxobutyric acid], (B) 0.5-5wt./vol% crystalline cellulose and/or CMC-Na, (C) 0.01-15wt./vol% magnesium aluminate metasilicate and (D) 0.01-15wt./vol% cyclodextrin. The syrup becomes a uniform suspension by the action of the suspending agent of the component (B), and irritant taste is eliminated by the component (C). The coagulation of particles can be prevented by the component (D). Thus, the titled suspended syrup is stable even to high-temperature sterilization and the irritant taste can be reduced without causing coagulation even in preservation for a long period. The syrup can be readily administered even to infants.
The present invention relates to a kind of Chinese medicine compositions for treating sufficient moss, comprising: 5-10 parts of loquat, 5-10 parts of Fructus Forsythiae, 5-10 parts of radix bupleuri, 5-8 parts of tripterygium wilfordii, 10-20 parts of wrinkled giant hyssop and 5-10 parts of the bark of ash.Preparation method are as follows: S1. mixes the loquat of recipe quantity, Fructus Forsythiae and radix bupleuri, crushes, obtains mixed powder A；S2. the tripterygium wilfordii of recipe quantity, wrinkled giant hyssop and the bark of ash are mixed, crushes, obtains mixed powder B；S3. 50-100 parts by weight water is taken, is heated to 70-80 DEG C, the mixed powder A of half is added, 15-20min is stirred, adds 1/3 mixed powder B, continues to stir 20-30min, obtains mixed liquor；S4. remaining mixed powder A and mixed powder B are uniformly mixed, then are added in mixed liquor by several times, stir to obtain admixing medical solutions；S5. be centrifuged, take supernatant, be concentrated, dry, pulverize to get.Preparation method is simple, and effect is good, at low cost.
OBJECTIVE: To evaluate the viability of the vaginal route as an alternative to laparoscopy for patients seeking permanent surgical contraception.
METHODS: We conducted a retrospective cohort study in 2021, dividing patients into two groups based on their preference: vaginal and laparoscopic salpingectomy. The statistical analysis was conducted using STATA, employing standard statistical methods based on the distribution of variables.
RESULTS: The study included 64 patients, with 34 undergoing the vaginal approach and 30 the laparoscopic route. No statistically significant differences were observed in baseline characteristics or complications between the two groups. Both surgical methods were found to be feasible. The vaginal route demonstrated a significantly shorter mean surgical time (P < 0.001). The laparoscopic route exhibited significantly less intraoperative blood loss (P < 0.001) and fewer hospitalization hours (P = 0.008). Postoperative satisfaction and pain levels did not show statistically significant differences.
CONCLUSION: Vaginal salpingectomy is a feasible technique with low complication rates, making it a potential option for gynecologists to offer their patients. We propose vaginal route inclusion in the training curriculum for gynecologic surgeons during the residency program, without any subspecialty requirements.
The invention belongs to a Chinese herbal medicine preparation, particularly relating to an eliminating cancer liquid of traditional Chinese medicine preparation for treating liver neoplasms, also having effect for treating other tumors and having miraculous effect for treating liver cirrhosis. The medicine consists of nox vomica, muskiness, morigimi (house lizard), pangolin, notoginseng, mylabris radix asparag, asafetida, centipede, rhizome coptidis, radix paeoniae alba, and liquorice; a liquid medicine is prepared after decocted with water and processed. The medicine components have high toxicity, but have remarkable efficacy for fighting against tumor and suppressing cancer cells; tumor can be cured by eradication, but the compatibility of medicines must be carried out scientifically, thus lowering the toxicity. After decocted with water, the traditional Chinese medicine is made into liquid. When applied externally to the afflicted part, the medicine can directly reach the ailment place and is absorbed and endosmosed through sweet gland with quick and strong effect. The usage is that 150-250 milliliters are taken for one dose and is heated to a boiling point; a sterilized towel is bedewed with the medicine liquid and compressed on the afflicted part; when the climate is chill and cold, warm water bag can be used for regulating the towel, and the medicine liquid is changed every 7-8 hours; the practice of the liniment is to be exerted flexibly according to the conditions of patients. The invention has the advantages that the healing effect is good; the cost is low; the course of treatment is short; the effect is rapid; the toxic and side effect is small.
PURPOSE OF REVIEW: Cervical spine pain with or without radicular symptoms is a common condition leading to high utilization of the healthcare system with over 10 million medical visits per year. Many patients undergo surgical interventions and unfortunately are still left with neck and upper extremity pain, sometimes referred to as "Failed Neck Surgery Syndrome." When these options fail, cervical spinal cord stimulation can be a useful tool to decrease pain and suffering as well as reduce prescription medication use.
RECENT FINDINGS: Spinal cord stimulation is a well-established therapy for chronic back and leg pain and is becoming more popular for neck and upper extremity pain. Recent studies have explored cervical spinal cord stimulation with successful outcomes regarding improved pain scores, functional outcomes, and reduction of prescription medication use. Continued research into cervical spinal cord stimulation is essential for maximizing its therapeutic potential for patients with chronic neck and upper extremity pain. This review highlights the importance of cervical spinal cord stimulation as an option for patients with failed neck surgery syndrome.
Participants will be given a daily step count goal of 8,000 steps per day based on the Actigraph watch, between 20 and 36 weeks of gestation. If they are not at goal, a step-up protocol will be designed for each participant and reviewed with a study team member every 2 weeks.
The degree of asymmetry in humans and the complication of mechanisms of interhemispheric interaction are formed mainly in the process of learning, but the impact of developmental teaching methods on the regulation of nervous functions in children with intellectual disability has been little developed. The aim of the work is to study the influence of developmental teaching methods on the regulation of nervous functions in children with mental development disorders and interhemispheric asymmetry of the brain. The information obtained in the data must be taken into account when organizing the learning process in the elementary school when working with mentally retarded children, when forming classes, when choosing programs, methods of teaching, when organizing psychological and pedagogical support. The age features of the brain associated with advanced development of right hemispheric functions are almost not used in it. Meanwhile, the active use of opportunities of the right hemispheric way of processing information, especially in elementary school, promotes the development of the child's abilities, allows to predict and increase the efficiency of school training. The functional contributions of the right and left hemispheres to the formation of the human psyche are assumed to be different because the hemispheres in their paired work function differently in time. The paired work is carried out in the present tense, so that the right hemisphere relies on the past, the left on the future tense. Therefore, the preservation of paired hemispheric functioning and structural integrity of the brain is the main condition, without which full-fledged mental activity cannot be formed.
Currently, in vitro testing examines the cytotoxicity of biomaterials but fails to consider how materials respond to mechanical forces and the immune response to them; both are crucial for successful long-term implantation. A notable example of this failure is polypropylene mid-urethral mesh used in the treatment of stress urinary incontinence (SUI). The mesh was largely successful in abdominal hernia repair but produced significant complications when repurposed to treat SUI. Developing more physiologically relevant in vitro test models would allow more physiologically relevant data to be collected about how biomaterials will interact with the body. This study investigates the effects of mechanochemical distress (a combination of oxidation and mechanical distention) on polypropylene mesh surfaces and the effect this has on macrophage gene expression. Surface topology of the mesh was characterised using SEM and AFM; ATR-FTIR, EDX and Raman spectroscopy was applied to detect surface oxidation and structural molecular alterations. Uniaxial mechanical testing was performed to reveal any bulk mechanical changes. RT-qPCR of selected pro-fibrotic and pro-inflammatory genes was carried out on macrophages cultured on control and mechanochemically distressed PP mesh. Following exposure to mechanochemical distress the mesh surface was observed to crack and craze and helical defects were detected in the polymer backbone. Surface oxidation of the mesh was seen after macrophage attachment for 7 days. These changes in mesh surface triggered modified gene expression in macrophages. Pro-fibrotic and pro-inflammatory genes were upregulated after macrophages were cultured on mechanochemically distressed mesh, whereas the same genes were down-regulated in macrophages exposed to control mesh. This study highlights the relationship between macrophages and polypropylene surgical mesh, thus offering more insight into the fate of an implanted material than existing in vitro testing.
Pediatric cardiomyopathies (CMs) and electrical diseases constitute a heterogeneous spectrum of disorders distinguished by structural and electrical abnormalities in the heart muscle, attributed to a genetic variant. They rank among the main causes of morbidity and mortality in the pediatric population, with an annual incidence of 1.1-1.5 per 100,000 in children under the age of 18. The most common conditions are dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). Despite great enthusiasm for research in this field, studies in this population are still limited, and the management and treatment often follow adult recommendations, which have significantly more data on treatment benefits. Although adult and pediatric cardiac diseases share similar morphological and clinical manifestations, their outcomes significantly differ. This review summarizes the latest evidence on genetics, clinical characteristics, management, and updated outcomes of primary pediatric CMs and electrical diseases, including DCM, HCM, arrhythmogenic right ventricular cardiomyopathy (ARVC), Brugada syndrome (BrS), catecholaminergic polymorphic ventricular tachycardia (CPVT), long QT syndrome (LQTS), and short QT syndrome (SQTS).
Project THINK is a 30-minute self-guided digital intervention designed to teach children and adolescents how to change the way that they think. Specifically, Project THINK is based on the principles of cognitive restructuring, a core component of cognitive behavioral therapy, a gold standard treatment for internalizing disorders. Project THINK uses vignettes, interactive activities, and engaging graphics to teach youth a systematic strategy for assessing the presence of unhelpful thoughts and replacing them with more helpful ones. Although not yet formally tested in a randomized trial, Project Think has been used by hundreds of students, and feedback has been very positive.
Controls were randomly selected from the Population register who were between 18-60 years old, had no diagnosis of mild traumatic brain injury during the period 1st of January 2003 - 31st of December 2007 and were gainfully occupied or deemed available for work the week preceding the time of injury. One control was matched for each mTBI case on gender, municipality and age (year of birth +/- 0,5 years). In case of no matching control the age criterion was expanded to (year of birth +/- 1 year), if still no matching control the age criterion was further expanded to (year of birth +/- 2 year). Additionally, controls were excluded according to the same criteria as the included cases.