anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A linker for multicomponent dosage form has a preformed drug substance tablet and an injection molded jacket including one or both axial jacket ends open for dispensing the preformed drug substances. The jacket has snap-fit connection elements on the outer surface adjacent each end for engagement with complementary snap-fit element on capsule-type and cap-type dosage form units. Another multicomponent drug form linker is injection molded with a raised circumferential band and snap-fit elements between the band and respective ends engageable with complementary snap-fit elements on dosage form units to provide compressive abutting contact between ends of the units and the band. The band can have an axially tapered outer surface to accommodate dosage form units of different diameters. Still another multicomponent dosage form linker has separable male and female parts each engageable with, and separately sealing, respective dosage form units to be linked. Circumferential complementary grooves, groove segments, ridges and ridge segment-type snap-fit elements are disclosed, as are dosage forms using the above-described linkers.
Viral hemorrhagic septicemia virus (VHSV) affects over 80 fish species, leading to viral hemorrhagic septicemia (VHS). Horizontal VHSV transmission is widely studied, with researchers utilizing various doses to establish infection models. Infected hosts shed the virus into the environment, elevating the risk of transmission to naïve fish within the same system. This study aimed to ascertain the minimum infective dose of VHSV in olive flounder (Paralichthys olivaceus). In olive flounder, the detection of VHSV within the kidney exhibited the highest infection rate on the third day among days 1, 3 and 5. Doses of 103.0 to 104.7 TCID50/ml were administered to juvenile olive flounder across three farms. Results showed resistance to infection below 103.4 TCID50/ml at 15 °C. While infection frequency varied by concentration, higher concentrations correlated with more infections. Nonetheless, viral copy numbers did not differ significantly among infected fish at varying concentrations. This study underscores the need for early VHSV management and contributes essential data for pathogenicity assessment and foundational knowledge.
We implement a PARDS ventilation bundle compliant with PALICC recommendations. The bundle contains a daily checklist for ventilation targets and reference tables listing targeted tidal volumes and end expiratory pressure-fraction of inspired oxygen titration. We will recruit mechanically ventilated patients who meet PARDS criteria. After a one-month implementation period, we will collect patient data over the subsequent 18 months, and compare them with the corresponding data in the 24 months prior to the implementation. The primary outcome is PARDS mortality, defined as number of deaths out of PARDS cases. Secondary outcomes are feasibility of ventilation bundle implementation, ventilator (VFD) and intensive care unit (IFD) free days and PICU mortality (number of deaths out of PICU admissions).
A Phase I, open label study of a single dose of 30 mg/kg of apramycin administered intravenously (IV) over 30 (+/- 5) minutes. Twenty subjects will be enrolled in the study to one of 5 cohorts, T1-T5, each corresponding to a timepoint after initiation of infusion at which a single fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) is performed. There will be 4 subjects per cohort. Cohort T5 will be enrolled after plasma and lung apramycin concentrations and preliminary PK data analysis are completed in cohorts T1-T4. Enrollment and dosing will be determined by bronchoscopy schedule. For each cohort, if 2 subjects are scheduled to receive study drug on the same day, the dose will be administered sequentially at least 2 hours apart. The primary objective is to assess plasma pharmacokinetic (PK) profile of apramycin and lung penetration of apramycin in epithelial lining fluid (ELF) and alveolar macrophages (AM) after single intravenous (IV) apramycin dose of 30 mg/kg in healthy subjects. The secondary objectives are to 1) assess the safety of single IV administration of 30 mg/kg apramycin in healthy subject and 2) to assess changes in otoacoustic testing.
A system and method for modeling patient-specific spinal cord stimulation (SCS) is disclosed. The system and method acquire impedance and evoked compound action potential (ECAP) signals from a lead positioned proximate to a spinal cord (SC). The lead includes at least one electrode. The system and method determine a patient-specific anatomical model based on the impedance and ECAP signals, and transform a dorsal column (DC) map template based on a DC boundary of the patient-specific anatomical model. Further, the system and method map the transformed DC map template to the patient-specific anatomical model. The system and method may also include the algorithms to solve extracellular and intracellular domain electrical fields and propagation along neurons. The system and method may also include the user interfaces to collect patient responses and compare with the patient-specific anatomical model as well as using the patient-specific anatomical model for guiding SCS programming.
The program's primary objective is to help young people and their parents through the early identification of mental health problems, such as anxiety, depression, substance abuse, and suicide. Screening strategies are based on the valid premise that suicidal adolescents are under-identified, suffer from an active, often treatable mental illness such as depression and exhibit identifiable risk factors (Gould et al. 2003). A potential shortcoming of screening programs is that asking about suicide could increase suicidal ideation and behaviour. About this issue a recent study (Gould et al . 2005) on over 2300 students reported no evidence of iatrogenic effects of suicide screening and that screening in high schools is a safe component of youth suicide prevention efforts.
OBJECTIVE: To analyze the clinical characteristics of multiple sclerosis (MS) patients complicated by disabilities in China, and to discuss the related factors of disease progression.
METHODS: Ninety-three MS patients presented to our hospital between March 2017 and December 2019 were selected as the research participants to conduct a retrospective analysis. Demographic information, onset time, onset age, clinical symptoms, MS types, and Expanded Disability Status Scale (EDSS) score were collected from all patients, and preliminary observation was made on MS cases in China. Subsequently, patients were grouped according to their sex, onset age and MS types to observe the differences in clinical characteristics of MS under different conditions. Finally, Logistic analysis was conducted to analyze the related factors affecting disease progression in MS patients.
RESULTS: MS was likely to occur in all age groups, among which the 30-40 age group had a slightly higher predilection. Women were more predisposed to MS, with motor symptoms as the major clinical presentations. The number of patients with sensory symptoms and the frequency of episodes in the past year were higher in female patients than in male patients (P < .05). Clinical isolated syndrome (CIS) patients had lower baseline ESDD than relapsing remitting MS (RRMS) patients (P < .05). According to Logistic regression analysis, baseline ESDD score and the frequency of episodes in the past year were independent risk factors affecting MS progression (P < .05).
CONCLUSIONS: The clinical characteristics of MS in the Chinese population are basically similar to those in foreign countries, but RRMS accounts for a relatively low proportion. The ESDD score and the frequency of episodes in the past year are independent risk factors for MS progression.
Of the 1634 patients in two pivotal multiple-dose Chronic Obstructive Pulmonary Disease (COPD) controlled trials, 405 were treated with FORADIL AEROLIZER 12 mcg twice daily. The numbers and percent of patients who reported adverse events were comparable in the 12 mcg twice daily and placebo groups. Adverse events (AE's) experienced were similar to those seen in asthmatic patients, but with a higher incidence of COPD-related AE's in both placebo and formoterol treated patients.

The following table shows adverse events where the frequency was greater than or equal to 1% in the FORADIL AEROLIZER group and where the rates in the FORADIL AEROLIZER group exceeded placebo. The two clinical trials included doses of 12 mcg and 24 mcg, administered twice daily. Seven adverse events showed dose ordering among tested doses of 12 and 24 mcg administered twice daily; pharyngitis, fever, muscle cramps, increased sputum, dysphonia, myalgia, and tremor.

Overall, the frequency of all cardiovascular adverse events in the two pivotal studies was low and comparable to placebo (6.4% for FORADIL AEROLIZER 12 mcg twice daily, and 6.0% for placebo). There were no frequently-occurring specific cardiovascular adverse events for FORADIL AEROLIZER (frequency greater than or equal to 1% and greater than placebo).

Other adverse reactions to FORADIL AEROLIZER are similar in nature to other selective beta2-adrenoceptor agonists; e.g., angina, hypertension or hypotension, tachycardia, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, muscle cramps, nausea, dizziness, fatigue, malaise, hypokalemia, hyperglycemia, metabolic acidosis and insomnia.
The invention relates to a method for preparing an enzymatic composition for acceleration of ageing of meat products involving a separate dissolution of an enzyme, viz. hyaluronidase and a prolongator of biological effect, viz. serum albumin at a pH value of from 2.0 to 2.5; hyaluronidase is taken in an amount of from 4 to 6 parts by weight and serum albumin in an amount of from 0.5 to 1.5 part by weight. Said aqueous solution of the enzyme is mixed with said aqueous solution of the prolongator, whereupon said ingredients chemically react with each other to give a suspension comprising a mixture of an aqueous solution of the desired product with suspended particles of the unreacted ingredients. After mixing of the aqueous solutions, the desired product is isolated by separation of the aqueous solution thereof from particles of the unreacted ingredients and precipitation of the desired product from said aqueous solution by means of an organic solvent at a volumetric ratio between said solvent and the solution of 4-10:1; the aqueous solution is previously cooled to a temperature of 4°-6° C.; the precipitate of the desired product is then separated from the liquid phase and dried in succession with acetone and ethyl ether. The enzymatic composition prepared according to the present invention has certain advantages over the prior art compositions employed for treatment of meat products. It is stable upon long-term storage and retains its activity unchanged at 18°-20° C. for 2 years and longer.
A medication delivery pen includes a housing having opposing proximal and distal ends. An actuator is disposed in the proximal end of the housing for setting and administering a dosage of medication. The pen also includes a medication-containing cartridge assembly having a cartridge with a pierceably sealed distal end, an open proximal end removably attachable to the distal end of the housing, and a piston in sliding fluid tight engagement within the cartridge. A drive mechanism is coupled between the actuator and the cartridge to exert an axial force on the piston to inject the set dosage of medication. The actuator triggers the drive mechanism to administer the injection of medication held in the cartridge. A processor is coupled to the actuator to determine a value equal to the dosage set by the actuator. A memory device is coupled to the processor to store at least the dosage value determined by the processor. A display is located on the housing and coupled to the processor for displaying information provided by the processor. In a first state the actuator engages with the drive mechanism to deliver the medication and in a second state is disengaged from the drive mechanism. In its second state, the actuator serves as a user adjustable input for changing and setting mode parameters of at least one preselected mode of the pen.
OBJECTIVE: This randomized controlled trial was conducted to determine the effect of acupressure and massage used for the management of labor pain in the latent, active, and transition phases of the first stage of labor on labor pain and birth satisfaction.
METHODS: The study was conducted with 66 pregnant women who met the sampling criteria and participated voluntarily at a public hospital in Nicosia. The participants were randomly assigned to one of three groups: a massage group, an acupressure group, or a control group. Participants in the massage group received 10 min of sacral massage during contraction and 10 min of endorphin massage during rest, for a total of 30 min of massage per phase. Participants in the acupressure group received 3 min of acupressure to the LI 4 point at the same dilation intervals, when the contraction was most intense. The control group received no intervention. Pain perceived by the pregnant woman was evaluated with the Visual Comparison Scale (VAS) at the beginning and end of each phase. Postpartum, the Birth Satisfaction Scale was applied.
RESULTS: Massage application was found to be more effective in reducing labor pain than acupressure or the control group. Massage and acupressure did not negatively affect APGAR scores. The lowest oxytocin use was found in the massage group. The group with the highest birth satisfaction scores was also the massage group.
CONCLUSION: Massage application is more effective than acupressure application in reducing labor pain and increasing birth satisfaction.
FIELD: medicine. ^ SUBSTANCE: group of inventions relates to field of veterinary virology. Vaccine includes vaccine strain of rabies virus, grown in inoculated cell culture and food and shape-forming components. As vaccine strain vaccine contains culture liquid, which contains avirulent rabies virus strain with infectivity titre 6.0-8.5 lg FFU50/cm3. As food and shape-forming components vaccine contains fish flour, beef fat, paraffin or food polymer and unrefined cereal grains, additionally it contains marker-tetracycline, with the following component ratio, wt %: culture liquid, which contains avirulent rabies virus strain with infectivity titre 6.0-8.5 lg FFUso/cm3- 1.0-4.0, tetracycline - 0.3-1.2, paraffin or food polymer- 5.0-10.0, unrefined cereal grains -5.0-15.0, fish flour- 30.0-40.0, beef fat - the remaining part. Method of vaccine obtaining lies in the following: vaccine rabies strain is grown in inoculated monolayer-suspension sublines of cells of Syrian hamster baby "ÆÜ"-21/13-02 or saiga kidney, obtained culture liquid, which contains avirulent rabies virus strain with infectivity titre 6.0-8.5 lg FFU50/cm3, is frozen at minus 20-40C. After that, tetracycline, paraffin, unrefined cereal grains, fish flour, beef fat are mixed for 25-30 minutes at temperature 55-60C. Obtained mass is poured into plastic moulds at temperature 40-45C. In each mould cell placed is culture liquid, which contains avirulent rabies virus strain and frozen at temperature minus 20-40C. ^ EFFECT: vaccine possesses high antigenic and immunogenic activity, is harmless, stable in storage, attractive for wild carnivorous animals. ^ 7 cl, 14 ex
The invention discloses a preparation method of a traditional Chinese medicine rhodiola solution for improving memory. The traditional Chinese medicine rhodiola solution comprises, by dry weight, 3-9 parts of rhodiola, 6-15 parts of pilose asiabell root, 3-10 parts of root of coriolus versicolor, 10-16 parts of root of kudzu vine, 3-10 parts of ligusticum wallichii, 3-10 parts of common fenugreek seeds and 10-20 parts of purslane. An ethanol solution for extraction has a concentration of 3-20% (by volume), first extraction time of the rhodiola solution is in a range of 8-20 days and second extraction time of the rhodiola solution is in a range of 4-8 days. The preparation method is simple and safe and has a low cost. The traditional Chinese medicine rhodiola solution has no toxic or side effect. The traditional Chinese medicine rhodiola solution realizes treatment on both symptoms and root causes chronic diseases formed in a long time and has effects of reducing blood viscosity, cleaning blood and cholesterol on the blood vessel wall, softening vessels, benefiting qi for activating blood circulation and satisfying body organs nutrient and oxygen demands. The traditional Chinese medicine rhizoma gastrodiae solution treats multiple symptoms through one formula, produces synergism and thoroughly improves memory.
Chronic kidney disease (CKD) is characterized by kidney inflammation and fibrosis. However, the precise mechanisms leading to kidney inflammation and fibrosis are poorly understood. Since histone deacetylase is involved in inflammation and fibrosis in other tissues, we examined the role of histone deacetylase 3 (HDAC3) in the regulation of inflammation and kidney fibrosis. HDAC3 is induced in the kidneys of animal models of CKD but mice with conditional HDAC3 deletion exhibit significantly reduced fibrosis in the kidneys compared with control mice. The expression of proinflammatory and profibrotic genes was significantly increased in the fibrotic kidneys of control mice, which was impaired in mice with HDAC3 deletion. Genetic deletion or pharmacological inhibition of HDAC3 reduced the expression of proinflammatory genes in cultured monocytes/macrophages. Mechanistically, HDAC3 deacetylates Lys122 of NF-κB p65 subunit turning on transcription. RGFP966, a selective HDAC3 inhibitor, reduced fibrosis in cells and in animal models by blocking NF-κB p65 binding to κB-containing DNA sequences. Thus, our study identified HDAC3 as a critical regulator of inflammation and fibrosis of the kidney through deacetylation of NF-κB unlocking its transcriptional activity. Hence, targeting HDAC3 could serve as a novel therapeutic strategy for CKD.
Active comparator: Those patients assigned to this interventional arm of the study will be asked to follow the same low-calorie diet of the experimental arm. During the first 4 weeks these patients will be asked to drink every morning, before breakfast, within 30 minutes, 500 mL of Rome tap water at room temperature.
A joint-tensioning system and method for automatically adjusting the tension applied to a joint. The system includes a joint tensioner (702) configured to tension a joint of a patient and a computer system. The tensioner (702) includes a blade (704) configured to be inserted between bones of the joint, an actuator configured to adjust a force exerted by the blade (704) on the bones of the joint, and a force sensor configured to detect the force exerted by the blade (704). The computer system can be configured to control the actuator to adjust the amount of force applied by the joint tensioner (702) to maintain the applied force within a defined range or at a defined value. The joint tensioner (702) may further comprise a strap (720) configured to be secured about a limb of a patient and wherein the actuator is configured to adjust the applied force exerted by the blade (704) by tightening or loosening the strap (720). The claimed system is especially useful during orthopedic procedures, such as total knee arthroplasties, wherein there is a need to perform a ligament balancing analysis.
Hepatitis B virus (HBV)-specific CD8+ T cells play a dominant role during acute-resolving HBV infection but are functionally impaired during chronic HBV infection in humans. These functional deficits have been linked with metabolic and phenotypic heterogeneity, but it has remained unclear to what extent different subsets of HBV-specific CD8+ T cells still suppress viral replication. We addressed this issue by deep profiling, functional testing and perturbation of HBV-specific CD8+ T cells during different phases of chronic HBV infection. Our data revealed a mechanism of effector CD8+ T cell attenuation that emerges alongside classical CD8+ T cell exhaustion. Attenuated HBV-specific CD8+ T cells were characterized by cytotoxic properties and a dampened effector differentiation program, determined by antigen recognition and TGFβ signaling, and were associated with viral control during chronic HBV infection. These observations identify a distinct subset of CD8+ T cells linked with immune efficacy in the context of a chronic human viral infection with immunotherapeutic potential.
In order to evaluate the usability of the 30SST, the validity of the test will be examined. In order to determine its validity in assessing functional capacity, the correlation of 6 MWT and 10SCT will be examined.
The participants follow the same stretching protocol but with neuromuscular electrical stimulation (NMES) added. Electrical stimulation (50Hz, 300 µs pulse width) is applied using an Enraf Nonius TensMed S82 device. Two 5x9 cm electrodes are placed on the hamstrings, and participants adjust the current to a moderate-strong, but painless, contraction. One researcher maintains the stretch, while another adjusts the current intensity and controls the timing of the stretching and contraction.
Hypertension is an important risk factor for cardiovascular diseases. Substantial evidence has also shown that prehypertension \[systolic blood pressure (BP) 120-139 mm Hg or diastolic BP 80-89 mm Hg\] is the strongest predictor of incident hypertension and is associated with elevated risk of cardiovascular diseases. Thus, prehypertension and its progression to hypertension have enormous public health implications. Soybean contains many beneficial components, among which isoflavones have received most research attention. Recently researchers have investigated their influences on vascular functions but only a handful of studies have focused on BP reduction as the primary outcome.The role of whole soy or daidzein on BP is yet unclear.

The investigators hypothesize that whole soy (soy flour) or purified daidzein alone could reduce BP,and decrease CVD risks in menopausal women with prehypertension or initial untreated hypertension. The investigators propose to perform a 24-week double-blind, randomized, placebo-controlled trial in postmenopausal women with prehypertension or stage 1 hypertension. The primary objective is to verify if whole soy (soy flour) or purified daidzein alone has anti-hypertensive effects at a dosage of habitual high soy intake.
Group 1 (Control) is the current standard of care in HIV testing. A trained counselor provides required information to obtain informed consent for HIV testing and provides rapid HIV testing on site.
<P>PROBLEM TO BE SOLVED: To provide a cosmetic base composition keeping sensory features of a vanishing cream base.  <P>SOLUTION: The cosmetic composition is substantially free of fatty acids and soap and yet displays the typical sensory and optical features of a vanishing cream. The composition comprises 3-10 wt% 12-22C fatty alcohol, 0.1-5 wt% emulsifier, 2-5 wt% inorganic agent, 0.1-5 wt% polymer and water. The inorganic agent comprises smectite clay. The composition is mild and may be used to stabilize and deliver a wide variety of skin benefit agents such as sunscreens.  <P>COPYRIGHT: (C)2006,JPO&NCIPI