anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To evaluate the incidence of postoperative complications after cytoreductive nephrectomy (CN) following first-line treatment for metastatic renal cell carcinoma (mRCC), and to compare it with postoperative complications of upfront CN.
METHODS: For this population-based retrospective study, the PearlDiver Mariner database (PearlDiver Technologies, Colorado Springs, CO), a database of insurance billing records was analyzed. Using relevant ICD-9/10 and CPT codes, patients diagnosed with mRCC between 2011 and 2021, who received first-line systemic molecular therapy (SMT), either tyrosine kinase inhibitors (TKI) or immune-checkpoint inhibitors (ICI), were identified. The selected population was stratified into two cohorts according to the timing of CN (deferred: after SMT vs. upfront: before SMT). Propensity-score matching (PSM) was performed as per baseline patients' characteristics to control for potential confounders between the two cohorts. The primary outcome was to compare 30-day postoperative complications rate between patients undergoing upfront vs. deferred CN.
RESULTS: After PSM, 162 patients who received upfront CN were compared with 162 patients who underwent deferred CN. The overall rate of 30-day postoperative complications was statistically significantly higher in patients undergoing deferred CN (33.9%), compared to patients treated with upfront CN (21%, p < 0.01). In addition, the rate of both medical (26.5% vs. 14.2%, p < 0.01) and surgical (14.8 vs. 7.4%, p = 0.03) complication rate was statistically significantly higher in deferred vs. upfront CN. Multivariable logistic regression analysis revealed that none of the treatment regimens significantly predicted the occurrence of postoperative complications.
CONCLUSION: Patients undergoing deferred CN experience a higher rates of overall, medical, and surgical 30-day postoperative complications compared to those receiving upfront surgery. Findings from this study should be interpreted within the limitations of this type of analysis.
Chronic obstructive pulmonary disease (COPD) stands as a significant global health challenge, with its intricate pathophysiological manifestations often demanding advanced diagnostic strategies. The recent applications of artificial intelligence (AI) within the realm of medical imaging, especially in computed tomography, present a promising avenue for transformative changes in COPD diagnosis and management. This review delves deep into the capabilities and advancements of AI, particularly focusing on machine learning and deep learning, and their applications in COPD identification, staging, and imaging phenotypes. Emphasis is laid on the AI-powered insights into emphysema, airway dynamics, and vascular structures. The challenges linked with data intricacies and the integration of AI in the clinical landscape are discussed. Lastly, the review casts a forward-looking perspective, highlighting emerging innovations in AI for COPD imaging and the potential of interdisciplinary collaborations, hinting at a future where AI doesn't just support but pioneers breakthroughs in COPD care. Through this review, we aim to provide a comprehensive understanding of the current state and future potential of AI in shaping the landscape of COPD diagnosis and management.
Sri Lanka demonstrates the most rapid aging process among countries in South Asia. The high prevalence of non-communicable diseases (NCDs) in the meanwhile results in more than 70% of deaths in the population, a factor that would curtail leisure activities of elders significantly. The objective of this study was to investigate the engagement of elders in leisure activities in Sri Lanka, and to examine the relationship between leisure activities and their well-being. The study was conducted in 2018 in a rural district of Sri Lanka adopting a mixed methods approach. Simple random sampling technique was used to select the respondents aged between 55 and 74 years, and face-to-face interviews were conducted with 300 respondents. Qualitative data was also collected from ten key informants while a few observations were also made on selected activities of elders in the study area. The research found that a two-thirds of the surveyed respondents were suffering from NCDs, showing a clear impact on their leisure activities. The presence of leisure activities was much lower among NCD affected elders (48%) compared to NCD free elders (80%). The majority of respondents possess sufficient and accurate knowledge on how to prevent NCDs, but they rarely practiced it. Leisure activities were significantly higher among males (75%) compared to females (43%). Males participated in leisure activities such as, gardening/agriculture etc. (99%), while females were engaged in religious activities such as visiting such places and meditation (98%). Leisure engagement demonstrated a positive impact on their life satisfaction. Although a sizable proportion of elders was engaged in leisure activities, analysis of both qualitative and quantitative data supported the view that the intensity of activities may not be helpful to maintain good health. Life satisfaction and well-being of elders are crucial for rapidly aging Sri Lankan society. Motivating elders and others, including school children, via strengthening of related policies and programs would reduce the NCD burden and enable present and future elders to enjoy a more fulfilling life in old age.
Part B: Multiple ascending doses of up to 400 mg LW231 tablets in healthy participants. Dosages will be determined from data collected from Part A.
BACKGROUND AND AIMS: Sepsis is a serious and life-threatening condition caused by a dysregulated immune response to an infection. Recent guidance issued in the UK gave recommendations around recognition and antibiotic treatment of sepsis, but did not consider factors relating to health inequalities. The aim of this study was to summarise the literature investigating associations between health inequalities and sepsis.
METHODS: Searches were conducted in Embase for peer-reviewed articles published since 2010 that included sepsis in combination with one of the following five areas: socioeconomic status, race/ethnicity, community factors, medical needs and pregnancy/maternity.
RESULTS: Five searches identified 1,402 studies, with 50 unique studies included in the review after screening (13 sociodemographic, 14 race/ethnicity, 3 community, 3 care/medical needs and 20 pregnancy/maternity; 3 papers examined multiple health inequalities). Most of the studies were conducted in the USA (31/50), with only four studies using UK data (all pregnancy related). Socioeconomic factors associated with increased sepsis incidence included lower socioeconomic status, unemployment and lower education level, although findings were not consistent across studies. For ethnicity, mixed results were reported. Living in a medically underserved area or being resident in a nursing home increased risk of sepsis. Mortality rates after sepsis were found to be higher in people living in rural areas or in those discharged to skilled nursing facilities while associations with ethnicity were mixed. Complications during delivery, caesarean-section delivery, increased deprivation and black and other ethnic minority race were associated with post-partum sepsis.
CONCLUSION: There are clear correlations between sepsis morbidity and mortality and the presence of factors associated with health inequalities. To inform local guidance and drive public health measures, there is a need for studies conducted across more diverse setting and countries.
A modular system and method able to carry out the following functions. Acquiring, standardizing and manipulating data obtained from any medical device, including digital data, waveforms, and administration of medication, images and lab results. Monitoring allowing customization of each view of the patient with his own characteristics and real-time visualization of included values: digital data, waveforms, video surveillance, medication and clinical milestones. Collecting information in a single powerful graphic user interface helping physicians to improve decision making and make clinical guides. Using statistical methods applied to real-time data helping to detect alerts and identifying physiological behavioral patterns. Connecting different medical devices to control the use of each device individually and transform the activity carried out in invoices.
BACKGROUND: The neuropathic pain with complex networks of neuroinflammatory activation severely limits clinical therapeutic research. TNF receptor-associated factor 6 (TRAF6) is associated with multiple inflammatory diseases. However, there remains confusion about the effects and mechanisms of TRAF6 in neuropathic pain.
METHODS: A chronic constriction injury (CCI) model was developed to simulate neuralgia in vivo. We overexpressed or knocked down TRAF6 in CCI mice, respectively. Activation of microglia by TRAF6, the inflammatory response, and disease progression were inspected using WB, qRT-PCR, immunofluorescence, flow cytometry, and ELISA assays. Moreover, the mechanism of M1/M2 polarization activation of microglia by TRAF6 was elaborated in BV-2 cells.
RESULTS: TRAF6 was enhanced in the spinal neurons and microglia of the CCI mice model compared with the sham operation group.. Down-regulation of TRAF6 rescued the expression of Iba-1. In response to mechanical and thermal stimulation, PWT and PWL were improved after the knockdown of TRAF6. Decreased levels of pro-inflammatory factors were observed in TRAF6 knockdown groups. Meanwhile, increased microglial M1 markers induced by CCI were limited in mice with TRAF6 knockdown. In addition, TRAF6 overexpression has the precise opposite effect on CCI mice or microglia polarization. We also identifed that TRAF6 activated the c-JUN/NF-kB pathway signaling; the inhibitor of c-JUN/NF-kB could effectively alleviate the neuropathic pain induced by upregulated TRAF6 in the CCI mice model.
CONCLUSION: In summary, this study indicated that TRAF6 was concerned with neuropathic pain, and targeting the TRAF6/c-JUN/NF-kB pathway may be a prospective target for treating neuropathic pain.
PROBLEM TO BE SOLVED: To obtain a medicinal composition made hardly to be taken out from capsule by an injection syringe at a room temperature by filling a soft gelatin capsule with a specific polyalkylene glycol, a thickener for forming a semi-solid from the polyalkylene glycol and the semi-solid including a medicine. SOLUTION: This medicinal composition is composed of a semi-solid polyalkylene glycol and a medicine. A liquid polyalkylene glycol having <=about 600 average molecular weight is made to the semi-solid by using a cellulose ether (e.g. huydroxypropyl cellulose having 80,000-1,150,000 molecular weight) as a thickener. The medicine (e.g. acetaminophen) preferably in an amount of about 0.1-40wt.% based on the whole semi-solid composition is included in the semi-solid composition. The objective medicine administrating shape material is obtained by setting the medicinal composition in a soft gelatin capsule as a filter and forming a semi-solid having < about 1,300MTU turbidity.
Telemedicine is a relatively new approach for the management of chronic obstructive pulmonary disease (COPD) disease. Telemedicine, for monitoring disease exacerbation, is the focus area of our research. The patient monitoring offers the possibility of early initiation of treatment of patients who has evidence of COPD exacerbation or pulmonary infection. The self-monitoring of potential exacerbation is started after a hospitalization, and is done by the patient on a daily (not on weekends) basis initially. After one month the monitoring is made at least three times weekly during the rest of the intervention period of six months. With the help of the monitoring equipment, the patient answers a short series of health related questions, and makes simple measurements of oxygen saturation, heart rate, lung function and weight. Data is sent to the hospital, and here the staff can assess the data and respond to them the same day, with a phone call to the patient, if the patient's condition has changed. The selected telemonitoring-equipment, consists of a monitoring systems for the assessment of key clinical parameters and symptoms. All patients, in the intervention group as well as in the control group, are trained in the use of a standardized self-treatment plan. It is expected that the monitoring of symptoms and signs will support patient empowerment.

The investigation is planned to assess the clinical and economic effects of the intervention.
NEW MATERIAL:A human lymphocyte surface antigen having an aminoacid sequence of the formula and the same active substance. USE:A reagent for researching autoimmune disease patients and a material for preparing a treating agent of the autoimmune diseases, cancer, infectious diseases, etc. PREPARATION:For example, a monocytic leukemia cell is cultured in a CO2 incubator, treated with a lithium chloride/guanidine thiocyanate solution, homogenized, layered on a cesium chloride solution and subsequently centrifuged to separate RNA, which is treated with an oligo dT cellulose column to prepare poly A<+> RNA. The poly A<+>RNA is used to prepare cDNA with a reverse transcriptase and further prepare cDNA library by a conventional method. The cDNA library is screened with a probe to select a DNA coding a human lymphocyte surface antigen, which is treating by a conventional method to prepare a manifestation vector. The vector is introduced into a host, transformed and cultured to provide the human lymphocyte surface antigen of the formula.
The E-learning intervention consists of two 20-minute e-learning modules that combine a didactic component with testimonials from respected professionals in the fields of addiction treatment and criminal justice. Module 1 describes the nature of opioid addiction and treatment modalities. Module 2 addresses specific criminal justice concerns of cost, acceptance, usefulness, and diversion, perceived obstacles to providing MAT access as described to us by Ohio criminal justice professionals in formative phase. All courts recruited for the study are exposed to E-Learning.
Anesthesiology consultation is mandatory in France for planned surgery. It is part of the concept of anesthesia safety. The main goal is to assess the anesthetic and surgical risk including clinical and drug features likely to interfere with the anesthesia. The medication reconciliation is a central part of this consultation especially in order to assess the allergic risk and hemostasis disorders.

However, access to comprehensive and reliable data concerning the consumption of health products by the patient represents a major challenge. The "Dossier Pharmaceutique" (DP) is an electronic pharmaceutical record including medications (prescribed medications, over the counter medications, complementary and alternative medicines) delivered by community pharmacists over a four month period. Hospital pharmacists have access to the DP of hospitalized patients in order to improve the quality of the medication reconciliation. These informations regarding medication of the patients will be shared with anesthesiologists.
Patients will receive 1 infusion of placebo within 1 week prior to concurrent chemoradiotherapy. Chemoradiation should start within 6 weeks after surgery and within 1 week maximum of the induction phase. Radiation will consist of 33 fractions over 6 weeks for a total of 66 Gy. Chemotherapy will consist of cisplatin 100 mg/m2 given on days 1, 22 and 43 of radiotherapy. Maintenance phase with placebo will begin within 1 to 28 days maximum after the end of radiotherapy and will consist of 6 doses administered every 4 weeks.
Aberrant activation of the NLRP3 inflammasome plays an essential role in complex diseases such as type 2 diabetes, multiple sclerosis, cryopyrin-related periodic syndrome, traumatic brain injury and Alzheimer's disease. Recently, the NLRP3 inflammasome-mediated response was investigated as a major contributor to the pathophysiological process of Alzheimer's disease. In the present invention, NLRP3 inhibitory compound 7 (NIC7), a novel small molecule inhibitor that inhibits the NLRP3 inflammasome, and a potent derivative NIC7w were identified. Specifically, NIC7w showed greater inhibition of interleukin-1β (IL-1β) in vitro compared to NIC7 in a concentration-dependent manner. Western blot analysis shows inhibition of key components of the NLRP3 signaling pathway, namely IL-1β and caspase 1. Next, the in vivo activity of NIC7 was confirmed in a mouse model of AD and showed improvement in cognitive behavior in mice. In addition, the pharmacological properties were verified by confirming the metabolic stability of NIC7 and NIC7w and inhibiting cytochrome P450 by the same. Overall, it suggests that NIC7 and NIC7w are potential therapeutics for NLRP3 inflammasome inhibition in Alzheimer's disease.
30 patients with a confirmed diagnosis of PPA (non-fluent PPA, logopenic PPA or semantic PPA) (made by a specialized clinician) will be recruited. Patients must have a mild to moderate language impairment and must be native English speakers. Exclusion criteria include contraindications to receiving Magnetic Resonance Imaging (MRI) scanning or rTMS (e.g. metallic or electromagnetically activated implants, cranial mass lesions, surgical aneurysm clips), the presence of significant medical, neurological or psychiatric co-morbid symptoms and patients without study partners.

It will take approximately 4 weeks to complete this research study, but the exact timing will vary according to patient, investigator and equipment availability. Each patient will have a total of up to 21 study visits. Greater than 21 visits may take place in the event that patients' language improves significantly following rTMS in order to test the sustainability of the improvement. Visits will take place at the MGH Martinos Center for Biomedical Imaging.

The first visit (lasting 3-4 hours) will include obtainment of informed consent, baseline assessments, and a baseline MRI scan (which will be used for subsequent rTMS targeting). After this, patients will return for two blocks of 20Hz rTMS to left dorsolateral prefrontal cortex: one in which they receive active rTMS and one in which they receive sham rTMS. Both active and sham rTMS will be delivered as high frequency stimulation (20 hertz, 20Hz). To accomplish this, an rTMS coil capable of delivering active or sham stimulation will be employed. Order of active and sham blocks will be counterbalanced across participants. During each block rTMS (active or sham) will be administered daily for 10 days (Monday through Friday). Neuropsychological testing, including thorough language evaluations, will be done before treatment, after day 1 and day 10 of rTMS treatment. Repeat MRI imaging will be performed after day 1 and day 10 of rTMS treatment. rTMS visit durations will be as follows: Monday (day 1) visit will last approximately 3-4 hours. Tuesday, Wednesday and Thursday and Friday visits (day 2 to day 9) will last approximately 1-2 hours. Friday visit (day 10) will last approximately 5 hours.
A method for making a rapid prototype of a patient's mouth to be used in the design and fabrication of a dental prosthesis. The method takes an impression of a mouth including a first installation site having a dental implant installed in the first installation site and a gingival healing abutment having at least one informational marker attached to the dental implant. A stone model is prepared based on the impression, including teeth models and model markers indicative of the at least one informational marker. The model is scanned. Scan data is generated from the scanning. The scan data is transferred to a CAD program. A three-dimensional model of the installation site is created in the CAD program. The at least one informational marker is determined to gather information for manufacturing the rapid protocol. Rapid prototype dimensional information is developed. The rapid prototype dimensional information is transferred to a rapid prototyping machine which fabricate a rapid prototype of the patient's dentition as well as a dental implant analog position.
Overactive bladder syndrome complicates life for many women. For 30 years the dominant treatment of overactive bladder syndrome has been antimuscarinics as first-line pharmacotherapy. 60-70% of women report improvement with treatment but the therapy is limited by the adverse events, for example dry mouth, obstipation and urin retention. In Sweden, prescription of antimuscarinics has increased by 69% during the period of 2000-2007 which implies an increasing desire to seek treatment.

Mirabegron is a b3-adrenoreceptor agonist which induces detrusor relaxation. Earlier studies have demonstrated similar efficacy when comparing Mirabegron with antimuscarinics but a significant reduction of adverse events. Clinical phase I-III trials have registered an increased pulse rate and effects on blood pressure in some patients. The aim of the present study is to survey cardiovascular adverse events with treatment with Mirabegron in the general population suffering from overactive bladder syndrome.
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to field of veterinary. As medication for treatment of gastrointestinal diseases in animals applied is hydrosol, which consists of silver clusters and distillated water. Applied is hydrosol with concentration of silver clusters 15 mg/l. ^ EFFECT: medication makes it possible to reduce terms of animal treatment. ^ 1 ex