anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Assessment of insulin sensitivity is an important objective of this substudy. Extrapolation from earlier studies suggests that insulin resistance will be associated with low testosterone levels at baseline in HIV-infected men with visceral obesity and that physiologic testosterone replacement in these individuals is likely to increase insulin sensitivity. However, direct assessment of insulin sensitivity under carefully controlled conditions is crucial to understanding the full metabolic impact of physiologic testosterone replacement in the context of A5079. The FSIVGTT, using the Bergman minimal model, has become a widely used method for the assessment of insulin sensitivity in epidemiological and intervention studies. Based on these considerations, the modified FSIVGTT was chosen as the optimal modality to assess insulin sensitivity in A5112s.

This study is a substudy of A5079. Patients enrolled in A5079 are eligible for this substudy but receive no study treatment other than that which they receive on A5079. Insulin sensitivity is measured by FSIVGTT performed at entry and at Weeks 24 and 48. In the modified FSIVGTT, 15 serial blood specimens for glucose are drawn over a 245-minute interval. The FSIVGTT assesses whether patients given testosterone supplements have more sensitivity to insulin than patients given a placebo.
Despite a large decline in new adult HIV infections in eastern and southern Africa from 2005-2015, progress has slowed in recent years. In particular, HIV risk among adolescent girls and young women remains high. Transactional sex, or the exchange of material support in non-commercial sexual relationships, is widely believed to be among the main driving factors for the HIV risk in this population. There is a large gap when it comes to interventions targeting men who engage in transactional sex. The proposed pilot project seeks to fill this important gap by using behavioral economic principles to promote behavior change among men.

The project will assess a novel prize-linked savings intervention designed to shift men's income away from alcohol and transactional sex and towards saving for the future. Prize-linked savings accounts offer savers a random, lottery-like payout proportional to the amount participants save, instead of traditional interest income. A number of banks, employers, and policymakers have promoted this low-cost, scalable approach to increasing savings among low-income individuals. However, there have been no assessments of whether prize-linked savings interventions can induce changes in key health-related behaviors as well. We will conduct a pilot randomized trial among men in Kenya to assess whether offering prize-linked savings opportunities leads to reduced spending on alcohol and transactional sex. The project will enroll men who in communities with high HIV risk, randomize them to the savings intervention, and assess changes in key economic and self-reported health outcomes over a 3-month period with baseline and follow-up surveys. We hypothesize that men randomized to the prize-linked savings intervention will have higher savings, lower expenditure on transactional sex, alcohol, and gambling, and lower rates of participation in risk behaviors such as transactional sex, relative to men randomized to the standard bank account control group.
PURPOSE:To provide stable, high quality skin cosmetics free of artificial perfumery and colorant, containing powdered orange juice prepared from inline-emulsion obtained by pressing whole orange fruits with an inline juicer. CONSTITUTION:Inline-emulsion obtained by prssing whole orange fruits with an inline juicer, is mixed with 10-50 wt% of water. The mixture is wrapped with a filter cloth, and slowly squeezed to obtain the filter cake containing 30-50% of water. The orange juice is added with saccharides, natural gums, decomposition products of starch, etc., to attain a solid content of 20-50%. The mixture is emulsified by agitation, and dried. The resulting powdery orange juice is added to the basic composition of skin cosmetic (e.g. oil, fat, wax, higher alcohol, etc.), and the objective skin cosmetic having natural perfume and color, and giving the mild and combined activities of vitamin C, E, D, etc., is obtained.
The present invention relates to new medicine, particularly to a Tonglinxiaozheng particle for treating the carcinoma of a urinary bladder and a preparation method thereof. The particle is prepared from traditional Chinese medicine such as rhubarb, peach kernel, etc. Water is added to the medicine, and the medicine is decocted for three times. Paste is obtained by concentrating a filtered solution. The steps comprise spray drying, the addition of dextrin, granulation and drying. A medicine effect is verified by the experiments of the animal models of fleshy tumors and liver cancers, etc. The Tonglinxiaozheng particle has the following effects: 1. the present invention has an obvious tumor inhibition effect for the growth of fleshy tumors of mouse S180; 2. the present invention has an obvious effect for activating blood circulation to dissipate blood stasis; 3. the present invention has an obvious analgesic effect; 4. the present invention has an obvious urination promotion effect. The Tonglinxiaozheng particle is taken by the mouse by 206.5 times than the clinical dosage of an adult, and the mouse have no poisoning symptoms and are alive. Consequently, the Tonglinxiaozheng particle is safe new medicine for effectively curing bladders.
Provided are a novel non-alcoholic fatty liver disease therapeutic or prophylactic agent and non-alcoholic fatty liver disease prophylactic food. The present invention is a non-alcoholic fatty liver disease therapeutic or prophylactic agent containing a green-algae-derived substance as an active ingredient. The green-algae-derived substance is chlorella. The present invention is used as a non-alcoholic fatty steatohepatitis therapeutic or prophylactic agent. The present invention is used as a liver fibrosis inhibitor. In addition, the present invention is a non-alcoholic fatty liver disease prophylactic food containing the green-algae-derived substance as an active ingredient.
Apparatus and method for performing surgical procedures within the mediastinum and within the pericardium include an endoscopic cannula having at least one lumen, a transparent tip, and an endoscope for introduction into the mediastinum and optionally into the pericardium via a single subxiphoid incision. A cavity may be initially dilated for advancing the endoscopic cannula using a dilating tool have an inner cannula and an outer expansible sheath that exerts a lateral-expansive, tissue-dilating force against the surrounding tissue cavity to allow the larger endoscopic cannula to be introduced into the mediastinum. Other surgical instruments, including a pericardial entry instrument are positioned through a lumen of the endoscopic cannula to cut a flap of the pericardium and create a small opening through which other surgical instruments such as an ablation probe or a restraining jacket may be introduced. All regions of the heart may be accessed by sweeping the endoscopic cannula around the heart through an aperture near the apex of the heart. Such access facilitates placement of epicardial tacks about the annulus of the mitral valve for supporting a tensioned suture or band to decrease the size of the mitral annulus to repair a regurgitant valve. Tensioning bands may also be tacked to the pericardium in order to inhibit distention of the heart.
The invention discloses a hydrogel dressing with bacteria in-situ detection and photoresponsive antibacterial function, and a preparation method and application thereof. The invention takes carboxymethyl chitosan and oxidized sodium alginate as raw materials and loads fluorescent substrate 4-methyl umbrella type ketone-beta-D-glucuronide and antibacterial agent UCNPs@TiO  2  Nanoparticles, forming a hydrogel dressing by a schiff base reaction. When bacteria exist at the wound, the hydrogel dressing can emit blue fluorescence under the excitation of ultraviolet light, and the infection degree can be identified and judged by naked eyes or a smart phone, so that the hydrogel dressing is practicalIn situ and rapid detection of bacteria at the wound site. Meanwhile, the hydrogel dressing has excellent photodynamic antibacterial performance under the irradiation of near infrared light, and a large amount of ROS can be generated in a short time to kill bacteria, so that the light-controlled antibacterial function is realized. In addition, the hydrogel dressing has good biocompatibility and can promote wound healing. The invention has important application value in the aspects of in-situ detection of wound pathogenic bacteria, prevention of infection and on-demand treatment.
Anesthesia induction is the same as before.At the end of the operation, sevoflurane was shut down and oxygen flow was increased to more than 7L/min. No other treatment was performed during extubation.
Current treatments for MS target the immune system and are not curative. There is much interest in MSCs as they have the potential to not only affect the immune system but may also promote repair. This study will use MSCs that are harvested from the bone marrow and grown for up to 52 days before being given back to the person from whom they were harvested. This avoids any chemotherapy so is therefore safer than other types of stem cells. In this crossover study, everyone will receive their own stem cells back but in half of the patients it will be delayed by 24 weeks.

The primary outcomes are to check that the procedure is safe and to measure any changes on the MRI at 24 weeks. Other more exploratory measures will try to assess effects on repair in the central nervous system (CNS).
Switzerland has the highest rate of new melanomas in Europe (19.2 per 100,000). Melanomas have the worst prognosis of all skin cancers. The current treatment depends on the histological diagnosis after a biopsy and is primarily related to the tumor thickness (Breslow Score), the tumor cells in division (mitosis rate), the substance defect of the skin (ulceration), the occurrence of regression, and the age of the patients. The initial treatment is performed by surgical removal with a safety margin of macroscopically healthy skin around the tumor. If the tumor thickness is more than 1 mm or more than 0.7 mm associated with a high mitosis rate in younger patients, ulcerations, regression or Clark Level IV / V, then current melanoma guidelines suggest that the patient undergoes sentinel lymph node biopsy (SLKB) as this is most likely the first site where metastases spread. Merkel cell carcinoma is a very aggressive, neuroendocrine skin tumor with a mortality rate of about 33% after 3 years. Due to the frequent lymphatic metastases, SLNB is highly recommended in all patients in order to better assess their prognosis. The gold standard technique to identify SLKs is to inject the radioisotope Technetium-99m around the primary tumor into the skin. The patient is then scanned to determine the position of the SLK after approximately 30 and 120 minutes. Other teams have attempted to identify transcutaneous SLK with ICG and NIRFI, but have concluded that ICG fluorescence technique is not reliable in patients with high BMI or a primary tumor with lymph drainage in the axillary lymph node region. This study aims to evaluate a medical device that uses an improved technology compared to previous studies (stereoscopic 3D high definition for both fluorescence and visible light imaging). The investigators hope is that by applying similar principles SLKs can be identified through the use of transcutaneous fluorescent dye injections and NIRFI.
Stroke is a leading cause of disability in the country, and ethno-racial inequities are persistent. Almost two thirds of stroke patients are discharged home without effective rehabilitation or community-based support. Falls can occur at home, and associated fear of falling leads to avoidance behaviors that limit physical activity and community reintegration. Here the investigators propose a novel intervention in a feasibility study for preliminary testing, integrating Task Specific Therapy at home guided by Community Health Workers (CHW) under supervision of a licensed Physical Therapist (PT) in conjunction with telehealth based Cognitive Behavioral Therapy (CBT) with reduce task specific fears through repetitive exposure and adaptive behavioral activation strategies to facilitate engagement in physical activity. The main objective is to assess the feasibility of this intervention. The secondary objective is to explore the underlying behavioral mechanism for behavior change and explore physical activity.
The present invention relates to cream for treating burn, scale and sore ulcer. The cream of the present invention is prepared from raw materials benne oil, calcium lime, lanolin, tween 80, coptis, borneol and nipagin methyl or nipagin ethyl by weight. The present invention aims at the pathological states of the burn, the scald and the sore ulcer of skin mucosa, and adopts medicine and addition agents with the advantages of good analgesic effect, good anti-infection effect, wound surface nourishing and moistening function, fast transdermal absorption and histotrophic nutrition substance supply. The cream has high pertinency on the burn, the scald and the sore ulcer, and has the advantages of high bioavailability and rapid curative effect taking. In the treatment process, people feel comfortable on wound surfaces, the restoration is fast, the healing effect is good, and the surface is smooth and flat after healed. The present invention also relates to a preparation method for the cream.
Novel bis-quaternary compounds of the formula <FORM:1036090/C2/1> wherein R1 is a halosubstituted phenyl radical, R2 and R3 are each hydrogen or a phenyl radical which may be halo-substituted, R4 is a hydrogen atom or a halosubstituted phenyl or benzyl radical, R5 is an amino or alkyl group, which may be substituted, R6 and R7 are each C1- 4 alkyl groups which may be substituted or R6 and R7 together with the nitrogen atom form a saturated heterocyclic ring which may be substituted, or R5, R6 and R7 together with the nitrogen atom form an unsaturated heterocyclic (e.g. pyridine) ring which may be substituted and A(-) is the anion of an acid yielding physiologically tolerable salts with the triamines, which may be a component of the radical R5, are prepared by reacting a reactive ester of the bis-hydroxyethylamine <FORM:1036090/C2/2> amine NR5R6R7.  Suitably NR5R6R7 may be a pyridinium, triethylammonium, tributylammonium, N - hydroxyethyl - N,N - diethylammonium, N - cyanomethyl - N,N - dimethylammonium, N - aminopiperidinium, N - carbethoxymethyl - N,N - diethylammonium or N - acetylaminoethyl - N,N - diethylammonium residue.  The preparation of bis chlorethylamines used as reactive ester starting materials is described.ALSO:Antibacterial preparations for technical disinfection e.g disinfection of floors or sanitary fixtures, or medicinal disinfection e.g. disinfection of the skin and of wounds, comprize a bis-quanternary compound of the formula wherein R1 is a <FORM:1036090/A5-A6/1> halo-substituted phenyl radical R2 and R3 are each hydrogen or a phenyl radical which may be halo-substituted, R4 is a hydrogen atom or a halo-substituted phenyl or benzyl radical, R5 is an amino or alkyl radical which may be substituted, R6 and R7 are each C1-6 alkyl groups which may be substituted for R6 and R7 together with the nitrogen atom form a saturated heterocyclic ring which may be substituted, or R5, R6 and R7 together with the nitrogen atom form an unsaturated heterocyclic (e.g. pyridine) ring which may be substituted and A\s8 is the anion of an acid yielding physiologically tolerable salts with the triamines and which may be a component of the radical R5, together with a carrier.  The preparations may suitably take the form of a solution, jelly, powder, ointment, paste, mixture requiring shaking, lincture or suspension.
Methods, devices and system are provided. One method includes capturing activity data associated with activity of a user via a device. The activity data is captured over time, and the activity data is quantifiable by a plurality of metrics. The method includes storing the activity data in storage of the device and, from time to time, connecting the device with a computing device over a wireless communication link. The method defines using a first transfer rate for transferring activity data captured and stored over a period of time. The first transfer rate is used following startup of an activity tracking application on the computing device The method also defines using a second transfer rate for transferring activity data from the device to the computing device for display of the activity data in substantial-real time on the computing device.
Prevention and treatment of osteoporosis require sensitive and specific assays of bone turnover. Presently, serum or urinary assessments are used. However, the development of other procedures that are more patient-convenient, non-invasive and cost-efficient would significantly facilitate a clinician's ability to determine bone turnover. The objective of this application is to determine the feasibility of using saliva for this measurement. We will compare serum, urinary and salivary levels in 50 pre- and 50 post-menopausal women. Markers to be measured are bone alkaline phosphatase, osteocalcin, procollagen type propepties hydroxypyridinium crosslinks of collagen and crosslinked collagen telopeptides. Collection of saliva, serum and urine will be done at a single visit. We expect to observe reasonable good correlation between serum and saliva levels and poorer correlation between urine and saliva levels.
The investigators will conduct evaluation of novel TB triage and diagnostic tests in a cohort of children with presumed TB. The investigators aim to enroll 250 participants per year at each of three enrollment sites for evaluation of various novel TB triage and diagnostic tests and 30 health workers to assess test usability. Novel test evaluations will be conducted on a rolling basis as new tests ready for field evaluation are identified.
Participants will receive VX-147 reference tablet under fasted condition in Treatment Period 1, then VX-147 test tablet under fed condition in Treatment Period 2, and VX-147 test tablet under fasted condition in Treatment Period 3. A washout period of 5 days will be maintained between 3 treatment periods.
Early induced therapeutic hypothermia represents the cornerstone treatment in neonates with probable hypoxic-ischemic encephalopathy. The selection of patients for treatment usually involves meeting criteria indicating evidence of perinatal hypoxia-ischemia and the presence of moderate or severe encephalopathy. In this review, we highlight the variability that exists between some of the different regional and national eligibility guidelines. Determining the potential presence of perinatal hypoxia-ischemia may require either one, two or three signs amongst history of acute perinatal event, prolonged resuscitation at delivery, abnormal blood gases and low Apgar score, with a range of cutoff values. Clinical neurological exams often define the severity of encephalopathy differently, with varying number of domains required for determining eligibility and blurred interpretation of findings assigned to different severity grades in different systems. The role of early electrophysiological assessment is weighted differently. A clinical implication is that infants may receive different care depending on the location in which they are born. This could also impact epidemiological data, as inference of rates of moderate-severe encephalopathy based on therapeutic hypothermia rates are misleading and influenced by different eligibility methods used. We would advocate that a universally endorsed single severity staging of encephalopathy is vital for standardizing management and neonatal outcome. IMPACT: Variability exists between regional and national therapeutic hypothermia eligibility guidelines for neonates with probable hypoxic-ischemic encephalopathy. Differences are common in both criteria indicating perinatal hypoxia-ischemia and criteria defining moderate or severe encephalopathy. The role of early electrophysiological assessment is also weighted unequally. This reflects in different individual care and impacts research data. A universally endorsed single severity staging of encephalopathy would be crucial for standardizing management.
BACKGROUND: Acute lymphoblastic leukemia is the most common pediatric malignancy, characterized by fever, anemia, hemorrhage, and symptoms brought on by blasts infiltrating organs.
CASE PRESENTATION: This is a case report of a 9-year-old Asian patient with acute lymphoblastic leukemia who presented with polyuria alone as a presenting feature without any other clinical manifestation; primary renal disease or inherited metabolic disease was highly suspected. However, the water deprivation test and water deprivation pressurization test suggested nephrogenic diabetes insipidus, and the renal biopsy displayed diffuse lymphocytic infiltration in the renal interstitium. Bone marrow aspiration was performed immediately, and a comprehensive diagnosis of B-lymphoblastic leukemia was finally made.
CONCLUSIONS: Renal infiltration with leukemic blasts mostly remains asymptomatic, but our case suggests that it can present with nephrogenic diabetes insipidus. This case fully demonstrates that the presentation of extramedullary infiltration in acute lymphoblastic leukemia is varied. When the patient has renal diabetes insipidus as the first symptom, the possibility of hematological tumor infiltration should be considered when finding the cause, and timely bone marrow cytology should be performed.
BACKGROUND: Riboflavin transporter deficiency (RTD) is an inborn error of riboflavin transport causing progressive neurological symptoms if left untreated. While infants with symptomatic RTD rapidly deteriorate, presentation later in childhood or in adulthood is more gradual. Symptoms overlap with more common diseases, carrying a risk of misdiagnosis, and given the relatively recent discovery of the genetic basis of RTD in 2010 it is likely that older patients have not been tested. Treatment with oral riboflavin (vitamin B2) halts disease progression and can be lifesaving. We hypothesized that patients may have been left unrecognized at the time of presentation and therefore we performed a datamining study to detect undiagnosed RTD patients in a tertiary referral hospital.
METHODS: A systematic search in Electronic Health Records (EHR) of all patients visiting the Amsterdam University Medical Centers between January 2004 and July 2021 was performed by a medical data text-mining tool. Pseudonymized patient records, matching pre-defined search terms (hearing loss or auditory neuropathy spectrum disorders combined with key clinical symptoms or riboflavin) were screened and included if no definitive alternative diagnosis for symptoms indicating possible RTD was found. Included patients were offered genetic testing. We documented total number of patients with possible RTD, number of patients that underwent genetic testing for RTD and results of genetic testing.
RESULTS: EHR of 2.288.901 patients were automatically screened. Thirteen patients with possible RTD were identified and offered genetic testing. Seven patients chose not to participate. Genetic testing was performed in 6 patients and was negative. The datamining did detect all previously known RTD patients in the hospital.
CONCLUSIONS: By screening a large cohort of patients of all ages in a tertiary referral hospital in a period spanning 17 years, no new RTD patients were found. Although not all suspected patients underwent genetic testing, our findings suggest that the prevalence of RTD is low and the chance of having missed this diagnosis in a tertiary referral hospital is limited.