anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to an intelligent tourniquet. An intelligent tourniquet for self-administration of a medicament is provided. When a patient needs to intravenously inject a drug into himself (referred to as "infusion"), the patient wears the smart tourniquet on their arm and tightens the device. While the patient is using the intelligent tourniquet, the device automatically records the date and time of the infusion, referred to as a "time stamp". The patient may also use the device to record the dose or "number of units" taken at the time of the infusion. The intelligent tourniquet may store the timestamp and other related information as a record. Later, the patient may review previous recordings on the intelligent tourniquet itself. The intelligent tourniquet may also be synchronized with an application and the record may be downloaded for review by the patient, nurse, or doctor for accurate and timely care.
The traditional system of routine outpatient follow-up of chronic disease in secondary care may involve a waste of resources if patients are well. The use of patient-reported outcomes (PRO) could support more flexible, cost-saving follow-up activities. AmbuFlex is a PRO system used in outpatient follow-up in the Central Denmark Region. PRO questionnaires are sent to patients at fixed intervals. The clinicians use the PRO data to decide whether a patient needs a visit or not (standard telePRO). PRO may make patients become more involved in their own care pathway, which may improve their self-management. Better self-management may also be achieved by letting patients initiate contact. The aim of this study is to obtain data on the effects of patient-initiated follow-up (open access telePRO) on resource utilisation, quality of care, and the patient perspective.
PURPOSE:To obtain the titled preparation useful for improving bacteria in the intestine, having stable effects, without administering an unnecessary resistant live bacterium, by previously blending a live bacterium agent for controlling intestinal function, showing resistance to a specific antimicrobial agent with the antimicrobial agent. CONSTITUTION:For example, a live bacterium agent for controlling intestinal function, showing resistance to antimicrobial agent such as penicillin drug or synthetic penicillin drug (e.g. oxacillin, cloxacillin or ampicillin) is blended with the antimicrobial agent. Streptococcus (Enterococcus) faecalis or Streptococcus lactis may be cited as the resistant live bacterium. Lactobacillus sporogenes, a kind of Bacillus coagulans, forms a spore and has possibility of use for the same purpose of the resistant bacteria. These useful bacteria are advantageously used.
Machine Learning (ML): A mixed data set of 353 WB-MRI scans as that comprising 50 healthy volunteers (scanned for the purposes of the study), and previously acquired scans from 303 myeloma patients, 100 of whom have inactive disease and 203 of whom have active myeloma. The scans will be read by radiologists in random order either with or without the support of for the detection of active myeloma. The diagnostic performance of the radiology reads with or without the machine learning support will be measured against an expert panel reference standard.
Gene regulatory divergence is thought to play an important role in adaptation, yet its extent and underlying mechanisms remain largely elusive for local adaptation with gene flow. Local adaptation is widespread in marine species despite generally high connectivity and is often associated with tightly linked genomic architectures, such as chromosomal inversions. To investigate gene regulatory evolution under gene flow and the role of inversions associated with local adaptation to a steep thermal gradient, we generated RNA-seq data from Atlantic silversides (Menidia menidia) from two locally adapted populations and their F1 hybrids, reared under two temperatures. We found substantial divergence in gene expression and thermal plasticity between populations, with up to 31% of genes being differentially expressed. Reduced thermal plasticity, temperature-dependent gene misexpression, and the disruption of coexpression networks in hybrids point toward a role of regulatory incompatibilities in local adaptation, particularly under colder temperatures. Chromosomal inversions show an accumulation of regulatory incompatibilities but are not consistently enriched for differentially expressed genes. Together, these results suggest that gene regulation can diverge substantially among populations despite gene flow, partly due to the accumulation of temperature-dependent regulatory incompatibilities within inversions.
Among obese patients with serum \[HCO3-\]\< 27 mmol/L, 300 randomized patients will be addressed to a pneumologist. The pneumology investigations will refute(or not)the diagnosis of OHS.
The Placebo treatment group will be administered eight placebo capsules per day. Placebo will be administered orally once daily for twenty-eight consecutive days. Dosing will take place at approximately the same time every day, approximately 15 minutes following the consumption of a standardized meal, and subjects must wait at least 1-2hrs after dosing before consuming additional calories. Water is permitted ad libitum.
A system comprising a moisture containing cleansing article and a visual pH indicator changing color at a pH above 4.0. The system can comprise a buffer, having preferably a pKa above 5.5. The system can comprise a set of instructions for evaluating moisture containing cleansing articles. The pH buffer of the system can have a pKa value equal to or greater than the pH of the color change of the visual pH indicator. The pH of color change of the visual pH indicator can be equal to or greater than the pH of the lotion. The system can be used to evaluate the pH of moisture containing cleansing article lotions and to quantify the ability to neutralize alkalinity such as the alkalinity provided by residues of feces and urine over time on the skin of a baby.
This study is a single-arm, multicenter, observational study. A total of approximately 30 subjects were be enrolled. The patient was orally administered with ripretinib150 mg QD. 4 weeks for one cycle. Efficacy was assessed every two cycles. For subjects with PR or SD after ripretinib treatment, resection of gastrointestinal stromal tumor was performed after discussion by MDT and ensure R0 resection as much as possible.Ripretinib 150mg QD was continued 2 weeks after surgery. Thereafter, subjectss entered the follow-up period for at least 1 year. Safety and survival information will be collected
A method for treating a patient's heart which comprising delivering a gene therapy agent into the pericardial sac around the patient's heart. The agent is introduced surgically or by transvascular means such as a catheter which has been introduced percutaneously or otherwise. Introducing the gene therapy agent into the pericardial sac contains the agent, allowing high concentration of the agent adjacent large regions of the epicardium and pericardium without spillage or systemic distribution to other organs or tissues. The gene therapy agents of this invention comprise vectors for transferring genetic information to the epicardial cells in vivo or harvested cells which have been genetically engineered in vitro. In a preferred embodiment, a catheter is percutaneously introduced, such as through the femoral artery, and guided upstream into the left ventricle. The distal end of the catheter advanced until it penetrates through the epicardium so that agent can be introduced into the pericardial space. Access to the pericardium may also be gained intraoperatively or through a thoracotomy. Additionally, the method may comprise employing a viscosity enhancer in conjunction with the gene therapy agent to affect the kinetics of the agent-host cell interaction and thus improve the rate and efficiency of transduction.
Substance use disorders (SUDs) are a leading cause of global disease burden with significant epidemiological and economic consequences. Sleep disturbances (i.e., difficulty initiating or maintaining sleep) are nearly ubiquitous in individuals with SUDs and may arise from direct effects of the substance or from withdrawal of the substance. Sleep disturbances are reported in up to 70% of individuals entering both detoxification and early recovery programs and may persist for months to years during abstinence. Objective and subjective measures of sleep disturbances are among the best predictors of relapse. Treatment of insomnia (i.e., difficulty initiating or maintaining sleep, with significant daytime impairment) during early recovery may improve relapse rates. Insomnia is a modifiable risk factor and responds to psychological interventions. Given the abuse potential of many medications utilized for sleep disturbances and the likelihood of drug-drug interactions over the course of detoxification, a non-pharmacological approach to insomnia remains promising. To date, few studies have evaluated non-pharmacological approaches to insomnia during early substance abuse recovery. One study has evidenced improved self-reported sleep quality in men who were assigned to 2 weeks of daily progressive muscle relaxation training. Robust evidence indicates that cognitive behavioral therapy for insomnia (CBT-I) is effective, and in fact is first line treatment for primary insomnia. A preponderance of randomized controlled trials of CBT-I in co-morbid populations suggests it is efficacious to address insomnia in context of ongoing medical and psychiatric illnesses. Despite the possibility that treating insomnia may improve relapse and attrition rates, and evidence that CBT-I is efficacious in improving sleep, there is a dearth of empirical data regarding the prophylactic benefit of initiating CBT-I as part of acute abstinence treatment. This study aims to test the feasibility of implementing a non-pharmacological insomnia intervention for individuals at the Cornerstone clinic at the Helping Up Mission, a residential SUD residential recovery program for men in Baltimore, MD. Participants will be recruited from the Cornerstone clinic, an accredited behavioral health clinic directed by Johns Hopkins faculty and staff, which provides evidence-based SUD treatment to residents of the Helping Up Mission. CBT-I will be incorporated into the outpatient reinforcement-based SUD treatment. The investigators hypothesize that implementation of CBT-I during early SUD recovery is feasible and will lead to improved sleep parameters and improved clinical outcomes compared with those receiving treatment as usual (TAU). The investigators propose a proof of concept study which would first demonstrate feasibility of administering CBT-I for individuals residing in a men's homeless shelter, and will further evaluate the short- and long-term efficacy of CBT for insomnia in individuals with SUDs. This investigation will provide important and novel information regarding potential psychological interventions that may be incorporated into evidence-based SUD treatment.
This study aimed to compare the acute inflammatory response following high-intensity eccentric exercise between resistance-trained young and master athletes with similar performance levels. Resistance-trained young (n=8; 22±2 years) and master (n=8; 52±4 years) male athletes of a similar performance level performed a standardized high-intensity eccentric squat exercise protocol (10 sets of half-squats at 70% of 1-repetition maximum). The serum concentration of 20 biomarkers related to tissue damage, inflammation, remodeling, and repair was measured at baseline, immediately after exercise, and over a 72 h recovery period. Both groups experienced similar muscle damage as evidenced by a comparable increase in creatine kinase activity 24 h after exercise (p<0.001). Interleukin-6 (p=0.009) and growth hormone (p<0.001) increased immediately post-exercise in both groups. Monocyte chemoattractant protein-1 increased immediately post-exercise only in young athletes (p=0.003) and then decreased 24 h later. There were no significant differences for the remaining variables, including cell markers related to neutrophil/macrophage activation or pro/anti-inflammatory cytokines. Resistance-trained young and master athletes, matched for performance level, showed an overall similar inflammatory response to eccentric exercise, possibly reflecting regulatory mechanisms or immunological adaptations to chronic stimulation in master athletes.
Currently, because of its good track record, femoral nerve block is the modality of choice for post-operative pain control following elective anterior cruciate ligament reconstruction at our institution. It has been proven in the literature to provide good post-operative pain analgesia following this procedure (1). However, femoral nerve block is not without its concerns, including the concern for long-term quadriceps weakness (2). Benefits of decreased use of Femoral Nerve Block include the decreased incidence of side effects and/or complications, and use of quadriceps for immediate rehabilitation. Benefits of Adductor canal nerve block include possible equivalent pain control with the avoidance of motor de-innervation and its deleterious adverse effect of quadriceps weakness postoperatively. Adductor canal nerve block has proven to be effective in other orthopaedic procedures involving the knee including total knee arthroplasty (3). This results of this study will give more information on how to better control pain in the post-op period while minimizing the deleterious side effects for patients undergoing ACLreconstruction.

All patients over the age of 16 undergoing primary or revision anterior cruciate ligament reconstruction with the use of bone-patellar-bone autograft are eligible for the study. Patients will be randomized pre-operatively to receive either an adductor canal nerve block (single injection) or a femoral nerve block (single injection). A single dose of 30 mL of 0.25% marcaine is injected for femoral nerve block and 20 mL of 0.25% marcaine for Adductor Canal nerve block. These procedures will be performed by the attending anesthesiologist prior to surgery. After surgery the patient will record their pain levels using visual analog scale (VAS) score in a daily diary for the first 5 post-operative days. They will also record all medication requirements, both narcotic and non-narcotic analgesic medications. The patient will be tested on their ability to perform a straight leg raise in the post-anesthesia care unit (PACU) and at their first post-operative visit.
Improving non-pharmacologic management of chronic pain is a priority for the Military Health System (MHS) within the Department of Defense (DoD) and the most common chronic pain condition in the MHS and civilian healthcare is low back pain (LBP). Key questions exist however about the relative effectiveness of various strategies at different Steps, how to sequence treatments and individualize care based on specific patient characteristics and the resource implications. This study will recruit active duty military members or members of Reserves or National Guard on active duty, family members of active duty personnel, or Tricare beneficiaries seeing a primary care provider for chronic LBP in an MHS facility, ages 18-65. All participants will first receive 6 weeks of Phase I care with either physical therapy (PT) or Move to Health (M2H) interventions. After Phase I the investigators will assess response to initial treatment strategy. Phase I responders will be receive up to 2 additional sessions of treatment to facilitate a transition to self-management. Phase I non-responders will be randomly assigned to a more intensive Phase II treatment of either mindfulness or a combined PT+M2H intervention for 8 weeks. Randomization at each phase will be stratified by site, gender, and active duty status (adding Phase I treatment assignment at Phase II). Follow-up assessments for all participants will occur at 18 weeks (conclusion of Phase II), 6 months and 12 months after enrollment. Outcomes include patient-reported measures and health care costs.
Folate Metabolism: In vitro, lamotrigine inhibited dihydrofolate reductase, the enzyme that catalyzes the reduction of dihydrofolate to tetrahydrofolate. Inhibition of this enzyme may interfere with the biosynthesis of nucleic acids and proteins. When oral daily doses of lamotrigine were given to pregnant rats during organogenesis, fetal, placental, and maternal folate concentrations were reduced. Significantly reduced concentrations of folate are associated with teratogenesis [see Use in Specific Populations (8.1)]. Folate concentrations were also reduced in male rats given repeated oral doses of lamotrigine. Reduced concentrations were partially returned to normal when supplemented with folinic acid.
An insoluble organic penicillin salt, e.g. the procaine, proflavine or gentian violet salt is dispersed in a liquid oleaginous base by incorporating in the penicillin salt-oil mixture one or more of the fatty acid partial esters of hexitol anhydrides and/or their polyalkylene oxide derivatives.  For parenteral application the oleaginous base may be a non-drying vegetable oil, e.g. rapeseed, cottonseed, poppyseed, peanut and sesame oils or a lower aliphatic ester of a fatty acid, e.g. ethyl oleate or stearate; for topical use liquid paraffin may be used. Waxes such as beeswax and spermaceti may be incorporated in these bases.  Preferred dispersing-agents are the fatty acid partial esters of sorbitan, sorbide, mannitan and mannide in which the fatty acid residues are of 12 to 18 carbon atoms, e.g. derived p  from oleic, lauric and stearic acids and the polyalkylene derivatives thereof having 25 molecules of oxide to one of anhydride and where the oxide is ethylene oxide or propylene oxide.  The preparations comprise not more than 1 per cent and preferably 0.125 per cent by volume of the dispersing-agent.ALSO:A redispersible suspension of an insoluble organic penicillin salt in a liquid oleaginous base is obtained by incorporating in the penicillin salt-oil mixture one or more of the fatty acid partial esters of hexitol anhydrides and/or their polyalkylene oxide derivatives.  Such salts are the procaine, proflavine and gentian violet salts of penicillin in a finely divided state.  For parental application the oleaginous base may be a non-drying vegetable oil e.g. rapeseed, cottonseed, poppyseed, peanut and sesame oils or a lower aliphatic ester of a fatty acid, e.g. ethyl oleate or stearate; for topical use liquid paraffin may be used. Waxes such as beeswax and spermaceti may be incorporated in these bases.  Preferred dispersing agents are the fatty acid partial esters of sorbitan, sorbide, mannitan and manaide in which the fatty acid residues are of 12 to 18 carbon atoms e.g. derived from oleic, lauric and stearic acids and the polyalkylene derivatives thereof having 25 molecules of oxide to one of anhydride where the oxide is ethylene or propylene oxide.  The preparations contain not more than 1 per cent and preferably 0.125 per cent by volume of the dispersing agent.
The invention relates to a traditional Chinese medicine capsule for reducing blood fat and removing atherosclerotic plaque, belonging to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine capsule is prepared from the following raw materials by weight: 30 to 40 parts of yeast powder, 11 to 21 parts of prepared rhubarb, 5 to 15 parts of pseudo-ginseng, 3 to 10 parts of glutinous rehmannia, 4 to 15 parts of prepared leech, 1 to 10 parts of stir-fried ground beetle, 1 to 9 parts of stir-fried gadfly, 1 to 8 parts of calcined dried lacquer, 1 to 5 parts of licorice root, 2 to 7 parts of root of large-flowered skullcap, 2 to 10 parts of peach seed, 5 to 10 parts of safflower and 5 to 10 parts of stir-fried bitter apricot kernel. The yeast powder, rhubarb, leech, ground beetle and gadfly in the capsule are used for reducing blood fat, removing plaque and resisting hemagglutination; removed plaque will not form thrombus, so blood vessels will not be blocked; lipid deposition in a body is reduced; metabolic disorders of a body are adjusted; oxidation damage is mitigated; and inflammatory response is inhibited. The root of large-flowered skullcap in the raw materials exerts anti-inflammation effect. The pseudo-ginseng, peach seed, dried lacquer, safflower and bitter apricot kernel are capable of activating blood circulation to dissipate blood stasis. Through combined usage of the bulk drugs, the prepared traditional Chinese medicine capsule is capable of reducing blood fat and removing atherosclerotic plaque and has good clinical application effect.
The present invention relates to monoclonal anti-human-GDF-15 antibodies. The antibodies include chimeric antibodies and humanized antibodies. The invention also relates to monoclonal anti-human-GDF-15 antibodies including murine antibodies, chimeric antibodies and humanized antibodies for use in methods for the treatment of cancer cachexia and also for the treatment of cancer. The invention also provides pharmaceutical compositions, kits, methods and uses and cell lines capable of producing the monoclonal antibodies of the invention. In particular embodiment the antibody is a humanized GDF-15 antibody wherein the heavy and light chain constant domains are 85% identical to SEQ ID NOs:29 and 32 and are able to bind the conformational or discontinuous epitope on human GDF-15 comprising SEQ ID No: 25 and SEQ ID No: 26. In a further embodiment this antibody is H1-L5 (humanized B1-23).
BACKGROUND: The aim of the study was to better understand the process through which recovery leads to teachers' exhaustion and performance. The direct and the indirect, i.e., mediated by teacher' work-related self-efficacy, effects of recovery on exhaustion and job performance were measured. To assessment of recovery, the Polish version of the Work-Related Rumination Scale (W-RRS) was developed. It measures detachment, affective rumination and problem-solving pondering. The psychometric properties of this tool constitute an additional contribution to the article.
MATERIAL AND METHODS: The study was conducted among a group of primary and secondary school teachers (N = 503). The factor structure of the W-RRS scale was checked using confirmatory factor analysis (CFA), its reliability by using of Cronbach's α measure, and its theoretical validity by means of correlation of main variables with criterion variables. Hypotheses related to direct and mediation effects were verified using structural equation modeling (SEM).
RESULTS: The obtained results confirmed the criterion and construct validity and reliability of the W-RRS. It has been also shown that detachment is directly negatively associated with exhaustion (but not with performance), affective rumination is a predictor of higher exhaustion and lower job performance, and problem-solving pondering is related to job performance (but not to exhaustion). Self-efficacy mediates the effect of 2 (out of the 3) types of recovery on exhaustion and job performance, such that high levels of problem-solving pondering and low levels of affective rumination translate into high self-efficacy, which in turn leads to lower exhaustion and higher job performance.
CONCLUSIONS: The recovery methods have various implications for functioning of teachers. While detachment and problem-solving pondering seem to promote it, affective rumination intensifies exhaustion and reduces performance. The mediator of the recovery-psychological well-being relationship is self-efficacy. The W-RRS questionnaire can be used to assessment of rumination among teachers. Med Pr Work Health Saf. 2024;75(2):143-158.