anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
People use various behaviors to cope with stressful events. These behaviors are mostly adaptive, as they allow a successful release of stress without impacting other aspects of life: How nice is it to have a break with a few spoons of that favorite ice cream during a hectic working day? However, when excessive consumption of high-sugar/salt ultra-processed food becomes the gateway to find relief from stress, eating loses this adaptive function and may escalate to binge eating, lead to obesity, and other medical conditions linked to overweight. Several etiological models attempt to explain stress-induced eating and excessive overeating behaviors characterizing these clinical conditions. The popular Emotional Eating Theory proposes that stress-related (over-)eating, a major predictor of obesity and diagnosed binge eating disorders, develops based on negative reinforcement learning since food consumption regulates the negative affective state associated with stressful circumstances. Differently, the prominent Incentive Sensitization Theory explains overeating, binge eating disorders (including bulimia), and obesity in terms of excessive amplification of reward 'wanting', which is thought to emerge from overexposure to obesogenic (food)cues. The several studies oriented by these theories have paved the way to better understand stress-related (over-)eating and its clinical excesses. However, a deep mechanistic understanding of how and why stress-induced (over-)eating can escalate till clinical forms of overeating remain elusive. A well-funded connection of the mechanisms proposed by the Emotional Eating Theory and the Incentive Sensitization Theory might address this etiological open question. To avoid erroneous arguments, it is however essential to first address the internal theoretical and methodological shortcomings of each theory and connected studies. These shortcomings stem from conceptual fallacies and poorly implemented designs, which might partially explain the 'high variability and low replicability' problem of empirical findings. Next, the formulation of a new integrative model could provide fresh insight into the deep learning and biological mechanisms of this escalation. A successful formalization of this model could then create the much-needed impact in clinical and preventive research since excessive overeating is a behavior hard to change once established. In this opinion paper, I propose to apply recent insights we gathered on the role of relief from the field of safety learning to stress (over-)eating. I will present a new relief-based model that, as a starting point, has the potential to connect the Emotional Eating Theory with the Incentive Sensitization Theory, setting the base for more integrative science.
Use the lowest effective dosage for the shortest duration consistent with individual patient treatment goals [see Warnings and Precautions ( 5)] . 

Apply diclofenac sodium topical gel gently to lesion areas twice daily to adequately cover each lesion. Use 0.5 g of gel (pea size) on each 5 cm x 5 cm lesion site. The recommended duration of therapy is from 60 days to 90 days. Complete healing of the lesion(s) or optimal therapeutic effect may not be evident for up to 30 days following cessation of therapy. Lesions that do not respond to therapy should be re-evaluated and management reconsidered. Avoid contact of diclofenac sodium topical gel with eyes and mucous membranes.
The invention discloses a rheumatism ostealgia treating capsule and a preparation method thereof. The capsule contains Chinese dates, angelica sinensis, mulberry twigs, loofah sponge, atractylodes lancea, incised notopterygium, radix angelicae pubescentis, lycopodium clavatum, rhizome of Scythian lamb, cassia twigs, homalomena occulta, cortex acanthopanacis, cynanchum paniculatum, sucrose, soluble starch, dextrin and ethanol. The capsule can effectively treat rheumatism ostealgia, expel wind, remove cold and relieve the pain of patients with rheumatism ostealgia to get the patients out of unbearable bone aches. The capsule can also enrich the blood and activate collaterals to make the patients more healthy and enhance the immunity of organisms, so the patients can resist secondary invasion of the aches. Various ingredients in the medicine can improve physical quality and make the patients strong and healthy. According to the prepared capsule, content in the capsule shell is in the form of brown particles which are moderate in size, strong in smell and good in fluidity and stability.
Disclosed is a rapidly dissolving granule formulation that is rapidly dissolved in the oral cavity. The granule formulation is rapidly dissolved in the oral cavity within 20 seconds after oral administration without leaving a feeling of foreign matter and a residual feeling. The granule formulation is produced by mixing an active ingredient with a rapidly dissolving carrier and granulating the mixture. The rapidly dissolving carrier meets the requirements: an instantaneous solubility of at least 30 mg/ml; a solubility after 5 minutes of at least 50 mg/ml; and the instantaneous solubility being 90% or less of a maximum solubility. The granule formulation can accomplish the desired effects irrespective of the kind of active ingredient. Therefore, the granule formulation is applicable to various active ingredients. In addition, the granule formulation can be produced in a relatively simple manner. This allows for an economical and efficient production process.
We present a novel case of acute invasive fungal rhinosinusitis (AIFRS) following a maxillary molar root canal in a 69-year-old diabetic female, who subsequently developed unilateral vision loss. The patient reported a 1-week history of progressive left facial pain, trismus, and numbness following the procedure. Initial evaluation was unremarkable, but her condition rapidly deteriorated, culminating in complete vision loss in the left eye. Imaging studies revealed opacification of the left-sided sinuses and a rim-enhancing collection in the left pterygopalatine fossa. Surgical debridement confirmed mucormycosis. The therapeutic approach included systemic and retrobulbar amphotericin B administration, along with multiple sinonasal debridements. The patient's poorly controlled diabetes mellitus significantly contributed to the rapid progression of the infection. Retrobulbar amphotericin B injections were effective in managing orbital involvement, thus avoiding the need for exenteration. Early diagnosis and aggressive treatment are paramount in improving outcomes for patients with AIFRS.
Patients meeting the inclusion criteria will be randomized or the experimental group of intraarticular injection of 50 mg doxycycline once every 2 two weeks for 4 weeks (day 1, week 2, week 4), with 20 patients in each group. Injections will be administered by the treating physician.
Hyperthyroidism is a condition where the thyroid gland produces high levels of thyroid hormone. Heart diseases are one of the main complications of hyperthyroidism. Several studies have shown that losartan (LOS) and diminazene aceturate (DIZE) possess cardioprotection effects against cardiac hypertrophy, ischemic heart disease, and heart failure. The research aimed to investigate the cardioprotection of LOS, DIZE, and their combination in the case of levothyroxine (LT4)-induced cardiomyopathy in rats. Hyperthyroidism was induced by LT4 in drinking water (12 mg/L) for 28 days. LOS (10 mg/kg, orally) and/or DIZE (15 mg/kg, subcutaneously) were administrated in rats with hyperthyroidism for 28 days. Decreased serum creatine kinase myoglobin and lactate dehydrogenase levels and cardiac hypertrophy by DIZE and combination therapy in hyperthyroidism rats have been reported. Cardiac hemodynamic findings showed that DIZE and its combination with LOS decreased the LT4-mediated left ventricular developed pressure (LVDP), rate pressure product (RPP), and RPP recovery percentage. Elevated cardiac oxidative stress and inflammation were confirmed by decreasing cardiac superoxide dismutase (SOD) activity and increasing the total oxidative stress and tumor necrosis factor-alpha (TNF-α) levels. SOD activity and TNF-α level were reversed by LOS and DIZE administration, respectively. Generally, DIZE and combination therapy with LOS improved cardiac dysfunction caused by hyperthyroidism in rats, whereas LOS alone has not been able to effectively respond to this dysfunction.
The invention relates to nutraceutical compositions useful in the treatment or prevention of diseases and/or disorders. In particular, the nutraceutical compositions contribute to strengthening of the immune system, resulting in the prevention and treatment of many diseases. A nutraceutical composition of the present invention comprises: C3 curcumin; Vitamin C; Chlorella, or an extract thereof, Spirulina, or an extract thereof; and Boswellia resin, or an extract thereof. An alternative nutraceutical composition of the present invention comprises: Coenzyme Q10; Spirulina, or an extract thereof; Moringa leaf, or an extract thereof; and Astaxanthin. The compositions may be used in the treatment or prevention of diseases such as chronic fatigue syndrome, immunodeficiency disorders, and viruses, in particular both acute COVID-19 infection and the COVID-19 sequelae or post viral fatigue known as long COVID. Furthermore, the compositions of the present inventions may be used in combination, or as a combination therapy in the treatment of different stages of a disease.
INTRODUCTION: Abscess of the bladder wall is a rare urological disorder, with a few cases recorded in the literature. The finding of a bladder wall mass via computed tomography (CT) imaging in a visiting patient is the subject of this report.
CASE DISCUSSION: A 37-year-old woman with persistent pain in the suprapubic area and lower urinary tract symptoms was examined as a case study. Through a CT scan revealed an inhomogeneous structure in the anteroinferior part of the right bladder. A cystoscopy procedure followed by transurethral resection was performed to remove the mass, which was found to be an abscess. A Foley catheter with irrigation was administered after surgery, and the patient goes home in three days.
CONCLUSION: the patient had no symptoms or discomfort in the lower urinary tract after follow-up. Despite the rarity of bladder wall abscesses, cystoscopy can be used to aid diagnosis. Transurethral resection of bladder wall can reduce the mass and eliminate the possibility of malignancy.
It is known that hypothermia occurs in approximately 50-90% of surgical patients under general anesthesia, and intraoperative hypothermia can lead to various complications such as wound infection, coagulation disorders, increased frequency of cardiac complications, ventricular fibrillation, prolonged effects of anesthesia drugs, shivering, and weakened immune function. Additionally, inadequate maintenance of temperature during surgery can result in delayed discharge from the recovery room, delayed recovery, and extended hospitalization. Therefore, accurate measurement of body temperature and active temperature management are crucial during surgery. Although there are various sites for temperature measurement, measuring the core body temperature in well-perfused deep tissues, which have a higher temperature and greater reliability than other sites, is essential. While esophageal temperature measurement is commonly used in patients undergoing general anesthesia, there may be cases where esophageal temperature probe cannot be inserted due to bleeding tendencies or lesions in the esophagus. In such cases, measuring temperature through the tympanic membrane or an endotracheal device becomes possible, but using a heated humidification breathing circuit for patient warming may affect the endotracheal temperature. Although there are animal study results comparing esophageal temperature and endotracheal temperature, research on the comparison of esophageal and endotracheal temperatures in humans is limited, and there is no study on the comparison of esophageal and endotracheal temperatures when using a heated humidification breathing circuit. The investigators aim to verify whether there is a temperature difference of 0.25 degrees or more between the temperature measured through the endotracheal device and the temperature measured by the esophageal thermometer when using a heated humidification breathing circuit. Through this investigation, they seek to determine which thermometer, either esophageal or endotracheal, is more appropriate to use in patients requiring the use of a heated humidification breathing circuit.
Human alphaherpesvirus 1 (HSV-1) establishes life-long latency in sensory neurons in trigeminal ganglia (TG), brainstem neurons, and other CNS neurons. Two important segments of the brainstem were examined in this study: principal sensory nucleus of the spinal trigeminal tract (Pr5) because it receives direct afferent inputs from TG, and locus coeruleus (LC) because it is indirectly connected to Pr5 and LC sends axonal projections to cortical structures, which may facilitate viral spread from brainstem to the brain. The only viral gene abundantly expressed during latency is the latency associated transcript (LAT). Previous studies revealed 8-week old female C57Bl/6 mice infected with a LAT null mutant (dLAT2903) versus wild-type (wt) HSV-1 exhibit higher levels of senescence markers and inflammation in LC of females. New studies revealed 1-year old mice latently infected with wt HSV-1 or dLAT2903 contained differences in neuroinflammation and senescence in Pr5 and LC versus young mice. In summary, these studies confirm HSV-1 promotes neuro-inflammation in the brainstem, which may accelerate neurodegenerative disease.
Malignant psoas syndrome(MPS)is characterized by intractable pain in the region innervating the first to fourth lumbar nerves resulting from the invasion of malignant tumors into the psoas muscle. A 57-year-old man underwent a right upper lobectomy with lymph node dissection for pStage ⅠB combined small cell lung cancer(SCLC). Adjuvant chemotherapy was subsequently administered in 2022. At 9 months postoperatively, metastases to the liver and lymph nodes of the hepatic portal region were detected. After multidisciplinary treatment, the recurrent lesions were identified as progressive disease. Eight months after the recurrence, the patient complained of severe pain in the left leg. Contrast-enhanced CT showed swelling of the left psoas muscle, and the patient was diagnosed with MPS. Usually caused by cancer of the abdominal organs, MPS is uncommon in patients with lung cancer. Here we report a case of combined SCLC presenting as MPS.
The invention relates to methods for producing humic substance-containing means which are used for protecting an organism against ionising radiation, is efficient in the form of a radioprotector and a therapeutic composition for accelerating the removal of radionuclides and heavy metals from an endamaged organism. The inventive method consists in exposing a humic substance and ammonium molibdate-containing aqueous solution to a wave radiation. The molibdate ammonium quantity is equal to at least 0.4 parts by weight per 1 part by weight of humic substances. The wave radiation treatment is carried out until a high molecular fraction content insaid humic substances is equal to or less than 5 %. Said wave radiation can be embodied in the form of a radiation selected from an ultrasound range of 18-66 kHz and a power of 0.5-5 W/cm3 or from an microwave range of 30-0.3 GHz and a power of 0.5-50 kW. The temperature of a processable product is maintained within a range of 60-70 °C for 30-90 minutes at the frequency of 2.45 GHz and a power of the microwave radiation equal to 5/W/cm3. The humic substances are produced by wood lignin oxidation.
FIT untethered is an open-label, randomized, repeated measures cross-over design study, testing glycemic control in "untethered" continuous subcutaneous insulin infusion (CSII) therapy compared to usual CSII therapy, in physically active patients with T1D (N=30). During 2-week screening visits, participants are randomized into either the usual CSII arm or the untethered CSII arm. Patients in the usual group continue with their established CSII therapy. Patients in the untethered group are to administer 50% of their basal dose through an insulin degludec injection every morning, with the other 50% achieved through their established CSII therapy. Bolus insulin remains at the established dose in both groups. After randomization, patients begin Phase I and transition into a 2-week insulin optimization period. Then, participants will complete 2 in-clinic, supervised exercise visits (1 moderate and 1 high intensity exercises) in the following week. After, participants must complete 2 unsupervised at-home exercises per week for 3 weeks (cumulative total of 2 moderate and 4 high intensity exercises). After the home exercise period, participants cross-over to the other study arm and begin Phase II. Phase II is similar to Phase I: 2 weeks of insulin dose optimization, 1 week of supervised clinic exercise, and 3 weeks of unsupervised home exercise. For both in-clinic and home-based exercise, the participant's insulin pump will be disconnected and suspended 60 minutes prior to beginning the workout, and will be reconnected immediately following each workout. A continuous glucose monitoring (CGM) device will be worn by each participant for the entire duration of the study. The co-primary outcomes of the study include time in range (4.0 - 10.0 mmol/L) in the 6 hours after the start of moderate- and high-intensity exercise. The key secondary outcomes include the glucose variability during the 24 hour period after the start of both moderate and high intensity exercise, and patient reported outcomes before and after exercise.
Systems and methods for providing a virtual professionals community for conducting virtual consultations with suggested professionals includes receiving, in a server, data associated with a plurality of professionals, including a specialty descriptive of one or more of the plurality of professionals. The server can receive a peer performance rating for one of the plurality of professionals generated by a second of the plurality of professionals. A client can submit, to the server, a search request that includes user-defined search criteria. The server can then search the received data based on the search criteria to select relevant professionals associated with the client's search request. The server can rank the selected relevant professionals based on peer performance ratings and the relevancy of the relevant professional to the search criteria. After ranking the selected professionals, the server can transmit a report of the relevant professionals ordered in the ranking determined by the server.
BACKGROUND: Timely diagnosis of neonatal sepsis is challenging. We aimed to systematically evaluate the diagnostic performance of sophisticated machine learning (ML) techniques for the prediction of neonatal sepsis.
METHODS: We searched MEDLINE, Embase, Web of Science and Cochrane CENTRAL databases using "neonate," "sepsis" and "machine learning" as search terms. We included studies that developed or validated an ML algorithm to predict neonatal sepsis. Those incorporating automated vital-sign data were excluded. Among 5008 records, 74 full-text articles were screened. Two reviewers extracted information as per the CHARMS (CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies) checklist. We followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) guideline extension for diagnostic test accuracy reviews and used the PROBAST tool for risk of bias assessment. Primary outcome was a predictive performance of ML models in terms of sensitivity, specificity and positive and negative predictive values. We generated a hierarchical summary receiver operating characteristics curve for pooled analysis.
RESULTS: Of 19 studies (15,984 participants) with 76 ML models, the random forest algorithm was the most employed. The candidate predictors per model ranged from 5 to 93; most included birth weight and gestation. None performed external validation. The risk of bias was high (18 studies). For the prediction of any sepsis (14 studies), pooled sensitivity was 0.87 (95% credible interval: 0.75-0.94) and specificity was 0.89 (95% credible interval: 0.77-0.95). Pooled area under the receiver operating characteristics curve was 0.94 (95% credible interval: 0.92-0.96). All studies, except one, used data from high- or upper-middle-income countries. With unavailable probability thresholds, the performance could not be assessed with sufficient precision.
CONCLUSIONS: ML techniques have good diagnostic accuracy for neonatal sepsis. The need for the development of context-specific models from high-burden countries is highlighted.
In order to provide placebo with an odor comparable to that of succimer, the Drug Distribution Center will place a small canister containing 200 mg of active drug into each bottle of placebo drug. A canister containing 200 mg of placebo will be placed inside each bottle of succimer so that all bottles will appear the same.
Fitbit Inspire 2 wearable plus 1 year subscription to premium Fitbit application. Subjects will also be provided with the OneTouch Verio Reflect glucose meter and the OneTouch Reveal (OTR) mobile diabetes app.
Part 1 is a dose escalation phase to evaluate the safety, tolerability, and define the MTD and RP2D. Part 1 is a 3+3 design.
In initiating treatment for type 2 diabetes, diet should be emphasized as the primary form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling the blood glucose and symptoms of hyperglycemia. The importance of regular physical activity should also be stressed, and cardiovascular risk factors should be identified and corrective measures taken where possible. Use of glyburide (micronized) or other antidiabetic medications must be viewed by both the physician and patient as a treatment in addition to diet and not as a substitution or as a convenient mechanism for avoiding dietary restraint. Furthermore, loss of blood glucose control on diet alone may be transient, thus requiring only short-term administration of glyburide (micronized) or other antidiabetic medications. 

Maintenance or discontinuation of glyburide (micronized) or other antidiabetic medications should be based on clinical judgment using regular clinical and laboratory evaluations.