anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Single or repeat-dose intravenous studies of collagenase clostridium histolyticum in rats were conducted to evaluate the toxicological impact of injection of collagenase clostridium histolyticum directly into the systemic circulation. Dose-dependent liver toxicity was noted at exposures greater than or equal to approximately 11 times the MRHD on a mg/m2 basis as characterized by elevated aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels, increased liver weights, mild regenerative anemia with secondary changes in the spleen and histologic findings of chronic active inflammation, hemorrhage/hematoma, fibrosis, bile duct hyperplasia and/or hepatocellular necrosis. The histologic findings remained unresolved following a 2-week recovery period, while the other findings resolved completely. Animals that were found dead or prematurely euthanized had histopathological findings of hemorrhage and necrosis in the liver and extramedullary hematopoiesis in the liver and/or spleen. Death occurred at approximately 25 times the MRHD on a mg/m2 basis between study days 7 and 15 following 8 repeat intravenous administrations of collagenase clostridium histolyticum over 16 days or after single intravenous doses at approximately 40 times the MRHD on a mg/m2 basis.

In intermittent 13-week subcutaneous repeat-dose studies in rats or dogs administered doses up to approximately 3 times the MRHD on a mg/m2 basis, respectively, there was no evidence of systemic toxicity. In a single-dose phase or 61-day repeat-dose phase (3 times a week every 3 weeks for 3 cycles) study of intrapenile administration of collagenase clostridium histolyticum in dogs at exposures lower than or equal to the MRHD on a mg/m2 basis, there was no evidence of systemic toxicity.
<P>PROBLEM TO BE SOLVED: To prevent processing from becoming complicated after medical inspection is entrusted.  <P>SOLUTION: An acceptance server 20 of a data center relays request information to be issued from request origin client terminals 17 and 19 to a request destination client terminal 17, and distributes it to the client terminal 17 of a medical facility (hospitals A to D) designated by the request origin. The acceptance server 20 stores the relayed request information. When the request destination which has accepted the inspection request based on the first request information entrusts another request destination, the acceptance server 20 stores second request information issued by the request destination through the acceptance server 20 as a new request origin to the entrust destination client terminal 17 by associating it with the previous first request information. Therefore, it is possible to easily grasp the request origin, the request destination (entrust origin) which has accepted the inspection request from the request origin, and the entrust destination to which the inspection request has been entrusted from the request destination on the basis of the both request information associated with each other. Thus, the processing is prevented from becoming complicated after the medical inspection is entrusted.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Although the medicinal properties of colchicine (COL) have been widely known for centuries, its toxicity has been the subject of controversy. The narrow therapeutic window causes COL to induce gastrointestinal adverse effects even when taken at recommended doses, mainly manifested as nausea, vomiting, and diarrhea. However, the mechanism of COL-induced gastrointestinal toxic reactions remains obscure. In the present study, the mice were dosed with COL (2.5 mg/kg b.w./day) for a week to explore the effect of COL on bile acid metabolism and the mechanism of COL-induced diarrhea. The results showed that COL treatment affected liver biochemistry in mice, resulting in a significant down-regulation of the mRNA expression levels of bile acid biosynthesis regulators Cyp7a1, Cyp8b1, Cyp7b1, and Cyp27a1 in liver tissues. The mRNA expression levels of bile acid transporters Ntcp, Oatp1, Mrp2, Ibabp, Mrp3, Osta, and Ostb in liver and ileum tissues were also significantly down-regulated. In addition, COL treatment significantly inhibited the mRNA expression levels of Fxr and its downstream target genes Shp, Lrh1, and Fgf15 in liver and ileum tissues, affecting the feedback regulation of bile acid biosynthesis. More importantly, the inhibition of COL on bile acid transporters in ileal and hepatic tissues affected bile acid recycling in the ileum as well as their reuptake in the liver, leading to a significantly increased accumulation of bile acids in the colon, which may be an important cause of diarrhea. In conclusion, our study revealed that COL treatment affected bile acid biosynthesis and enterohepatic circulation, thereby disrupting bile acid metabolic homeostasis in mice.
Methods, systems, and computer-readable mediums for generating, by an artificial intelligence engine, an alignment plan capable of enabling, during a treatment session, the aligning of a user's body. The method comprises generating machine learning models trained to identify alignment plans. The method also comprises receiving treatment data that comprises a first position of the user's body, aspects of a treatment plan, and one or more attributes of the user. The method further comprises generating the alignment plan by using the machine learning models. The generating is based on at least the aspects of the treatment plan and at least one of the one or more attributes of the user. The alignment plan may comprise a target position of the user's body and one or more elements for adjusting the user's body from the first position to the target position. The method also comprises transmitting the plan to a computing device.
PURPOSE: To obtain a depressant which is composed of a benzazepine type calcium channel blocker alone or in combination with an ACE depressant and suppresses the loss of perceptional function (it contains memorization ability) of mammals for a long period of time. CONSTITUTION: This depressant for loss of perceptional function is composed of a benzazepine type calcium channel blocker, e.g. diltiazem, a compound of the formula (R1 is H, an alkyl, an alkanoyl, an arylcarbonyl, etc.; R and R3 are each H, an alkyl, a cycloalkyl, etc., or are incorporated together with the nitrogen binded with them to form pyrrolidinyl and piperidinyl; R4 and R5 are each H, a halogen, an alkyl, an aryloxy, OH, CN, etc.; (n) is 2 and 3) alone or in combination of the compound with an angiotensin converting enzyme(ACE) depressant, e.g. a substituted proline derivative and a carboxyalkyldipeptide derivative. The medicine is useful for the treatment of vascular dementia such as initial denatured dementia caused in the senile and presenile generations and arteriosclerotic dementia or for the delay of the progress of the disease.
A free-living parallel, single-blind, RCT will be utilized. There will be two phases: Phase 1 - to examine the effects of Blueberries on plasma markers of immune strength, and Phase 2 - to assess the response to influenza vaccine following blueberry intake. Subjects will either consume their usual diet with (Blueberry group) or a placebo(control group) blueberries for 8 weeks, receive the influenza vaccination, and continue the intervention for another 4 weeks. The test food will be freeze-dried powder (FDP) (\~ to 1 cup fresh blueberries) per day with the usual diet. The control will be the placebo powder with some guidelines to restrict all berries and other polyphenol-rich foods. The entire study will last 12 weeks. Participants will attend a baseline clinic at which time they will be randomized to one of the two groups. Clinic visits will occur at baseline, weeks 4 and 8 before, and week 4 after vaccination.
Subjects with focal epilepsy that is not well-controlled on anti-seizure medications will receive 2 different treatments periods, each lasting 2 months, of transcranial direct current stimulation (tDCS). The last treatment stimulation will be completed during the following 2-months.
Participants randomized into the Standard treatment group will have a goal of SBP \<140 mmHg. It is expected to achieve a SBP of 135-139 mmHg in as many participants as possible. Medication dose titration or addition of another drug is indicated if SBP is ≥160 mmHg at a single visit or is ≥140 mmHg at two consecutive visits. Down titration should be carried out if the SBP is \<130 mmHg at a single visit or \<135 mmHg at two consecutive visits.
The present invention discloses a tincture for curing toothache, which is formed by that the provided Chinese herbal medicine is extracted according to a conventional tincture extracting method. The provided Chinese herbal medicine comprises verbena, common nandina, agrimony, etc. Compared with the prior art, the present invention has the effects of eliminating inflammation, alleviating ache, expelling wind, removing dampness, promoting intestines and stomaches, killing insects, clearing heat, removing toxicity, cooling blood and eliminating tumescence. The product can treat tooth diseases of decayed teeth, periodontitis, etc. The effective rate reaches more than 95%. When in use, the tincture for curing toothache is coated on the affected part by cotton. The tincture for curing toothache takes effect on mild patients from 10 minutes to 20 minutes. Critical patients are cured by using the present invention from 1 to 2 times. The product is permitted to be produced via the Qian Medicine Health Permission Number (94): Z-24 by the health department of Guizhou province.
Recombinant sarbecovirus vaccine based on the nucleocapsid of SARS-CoV-2. One single administration intramuscularly of a 100µg (0.2mL) dose on Day 1.
BACKGROUND: Breast cancers exhibit considerable heterogeneity in their biology, immunology, and prognosis. Currently, no validated, serum protein-based tools are available to evaluate the prognosis of patients with early breast cancer.
METHODS: The study population consisted of 521 early-stage breast cancer patients with a median follow-up of 8.9 years. Additionally, 61 patients with breast fibroadenoma or atypical ductal hyperplasia were included as controls. We used a proximity extension assay to measure the preoperative serum levels of 92 proteins associated with inflammatory and immune response processes. The invasive cancers were randomly split into discovery (n = 413) and validation (n = 108) cohorts for the statistical analyses.
RESULTS: Using LASSO regression, we identified a nine-protein signature (CCL8, CCL23, CCL28, CSCL10, S100A12, IL10, IL10RB, STAMPB2, and TNFβ) that predicted various survival endpoints more accurately than traditional prognostic factors. In the time-dependent analyses, the prognostic power of the model remained rather stable over time. We also developed and validated a 17-protein model with the potential to differentiate benign breast lesions from malignant lesions (Wilcoxon p < 2.2*10- 16; AUC 0.94).
CONCLUSIONS: Inflammation and immunity-related serum proteins have the potential to rise above the classical prognostic factors of early-stage breast cancer. They may also help to distinguish benign from malignant breast lesions.
Participants in the control group will receive usual care only. Usual care is recommended to include, but not restricted to, long-acting anticholinergics and long-acting ß2-antagonists with 24-hour duration and support for smoking cessation, PA and exercise, self-management and nutrition.
PROBLEM TO BE SOLVED: To save labor for storage and retrieval of medical images conducted by a medical facility itself. SOLUTION: A medical facility 10 transmits medical images taken by it to an image reading center 20 to request to make a report on the medical images. The image reading center 20 transmits the medical images to an image reading site 30 through a communication line to request to make a report on the medical images. The image analysis site 30 makes a report on the reading of the medical image, selects key images from the medical images, and transmits the report and the key images to the image reading center 20. The image reading center 20 transmits the report and the key images, which it has received from the image reading site 30, to the medical facility 10 and stores the report and the key images. The medical facility 10 may retrieve the report and the key images easily by accessing the image reading center 20, if necessary.
A wiping article is provided which includes an effervescent cleanser composition held within a pouch formed from a first and second substrate sheet. At least one of the substrate sheets must be water permeable. The effervescent composition is an intimate mixture of an acid material such as citric acid and an alkaline material such as sodium bicarbonate. Water contact causes the combination to effervesce. A dry surfactant such as sodium cocoyl isethionate in contact with the water and effervescing carbon dioxide results in a highly pleasant sudsing system. Skin benefit agents may be included within the composition. The effervescent action may improve deposition of the skin benefit agents onto the skin.
The present invention provides a preparation method of artemisine and a liposoluble derivative emulsion thereof. The raw material comprises the following components by weight ratio: 0.1 to 9.9 parts of an emulsifying agent, 100 to 1 part of artemisine or liposoluble derivative emulsion thereof, 0.2 to 1 part of oil for injection, and a surface active agent in a proper amount. The preparation method comprises the following steps: phosphatidyl choline or soybean phospholipid, the artemisine or the liposoluble derivative emulsion thereof and the surface active agent are weighted in proportion, mixed and uniformized; the solution is mixed with the oil for injection and microemulsified by a high pressure jet flow milk shaving machine to obtain a preparation, wherein the oil for injection is treated by hydration and ultrasonic wave; the preparation is bottled and packaged by a filling machine, and then an emulsion is prepared. The emulsion of the present invention has favorable water solubility, and the grain diameter can reach 0.05 to 1.0 mum. The emulsion of the present invention has a controlled release function and a target function to tumor tissue. The biological availability not only is favorable in intravenous injection, but also is increased in oral medicine. Compared with the congenic medicine in the prior art, the emulsion of the present invention has the advantages of simple preparation process, controllable medicinal preparation grain diameter, safety, reliability and high biological availability. The emulsion can be used for the treatment and the adjuvant treatment of lung cancer, liver cancer and lymph cancer, and the emulsion also has very good curative effect on heart rate malfunction.
Over the past 4 decades, the clinical care of people living with HIV (PLWH) evolved from treatment of acute opportunistic infections to the management of chronic, noncommunicable comorbidities. Concurrently, our understanding of adipose tissue function matured to acknowledge its important endocrine contributions to energy balance. PLWH experience changes in the mass and composition of adipose tissue depots before and after initiating antiretroviral therapy, including regional loss (lipoatrophy), gain (lipohypertrophy), or mixed lipodystrophy. These conditions may coexist with generalized obesity in PLWH and reflect disturbances of energy balance regulation caused by HIV persistence and antiretroviral therapy drugs. Adipocyte hypertrophy characterizes visceral and subcutaneous adipose tissue depot expansion, as well as ectopic lipid deposition that occurs diffusely in the liver, skeletal muscle, and heart. PLWH with excess visceral adipose tissue exhibit adipokine dysregulation coupled with increased insulin resistance, heightening their risk for cardiovascular disease above that of the HIV-negative population. However, conventional therapies are ineffective for the management of cardiometabolic risk in this patient population. Although the knowledge of complex cardiometabolic comorbidities in PLWH continues to expand, significant knowledge gaps remain. Ongoing studies aimed at understanding interorgan communication and energy balance provide insights into metabolic observations in PLWH and reveal potential therapeutic targets. Our review focuses on current knowledge and recent advances in HIV-associated adipose tissue dysfunction, highlights emerging adipokine paradigms, and describes critical mechanistic and clinical insights.
The investigators conduct an intervention study in a sample of 72 knowledge-workers, who engaged in mindfulness meditation or physical activities for five weeks. They performed from 15 to 30 minutes during their lunch breaks. The investigators randomly assigned participants to three experimental conditions: 1) mindfulness meditation, 2) physical activity, 3) control group (lunch break as usual). Online questionnaires before and after intervention assessed long term changes regarding recovery processes, perceived stress, health, mindfulness and burnout. For daily changes, a mobile application was developed to assess changes once per day immediately after work. The investigators also collect saliva samples to map cortisol and immunoglobulin A excretion across the intervention period. The investigators had two follow-up measures one and six months after the intervention.
EPI01 Formulation C (retarded release): 3 capsules each containing decitabine (5 mg) and THU (250 mg) administered under fasting conditions. Single oral administration with 250mL of water.
DACP worn first, followed by DACP MF and DACP MF (Low Add), as randomized. Lenses worn for 5±1 days, 6 hours per day, in a daily wear daily disposable modality. DACP worn as monovision (distance correction in one eye and near correction in the other eye).
The brain possesses intricate mechanisms for monitoring sodium (Na) levels in body fluids. During prolonged dehydration, the brain detects variations in body fluids and produces sensations of thirst and aversions to salty tastes. At the core of these processes Nax , the brain's Na sensor, exists. Specialized neural nuclei, namely the subfornical organ (SFO) and organum vasculosum of the lamina terminalis (OVLT), which lack the blood-brain barrier, play pivotal roles. Within the glia enveloping the neurons in these regions, Nax collaborates with Na+ /K+ -ATPase and glycolytic enzymes to drive glycolysis in response to elevated Na levels. Lactate released from these glia cells activates nearby inhibitory neurons. The SFO hosts distinct types of angiotensin II-sensitive neurons encoding thirst and salt appetite, respectively. During dehydration, Nax -activated inhibitory neurons suppress salt-appetite neuron's activity, whereas salt deficiency reduces thirst neuron's activity through cholecystokinin. Prolonged dehydration increases the Na sensitivity of Nax via increased endothelin expression in the SFO. So far, patients with essential hypernatremia have been reported to lose thirst and antidiuretic hormone release due to Nax -targeting autoantibodies. Inflammation in the SFO underlies the symptoms. Furthermore, Nax activation in the OVLT, driven by Na retention, stimulates the sympathetic nervous system via acid-sensing ion channels, contributing to a blood pressure elevation.
Curcuma longa in capsule form will be given with actual or placebo aspirin, each for a 3 week period. Clotting profile and platelet function test will be done before and after.
Participants in the intervention arm will receive training in using the eRAPID system to report their symptoms and side effects (at least on a weekly basis) from home via the internet whilst they are receiving treatment online and weekly for 6 weeks post treatment (a total of 12 weeks) and then at 18 \& 24 weeks. Hospital staff will be able to review eRAPID reports and use the information during the consultation in clinic, when attending radiotherapy or answering phone calls. Alerts will also be sent to the relevant clinical team when severe symptoms are reported by patients.
PURPOSE:To improve taste and flavor without impairing drug effects of an aloe by boiling liquid juice of aloe leaves, thick malt syrup and edible flour, dropping the resultant mixture onto dogtooth violet starch, extending the mixture into the shape of a rod and cutting the formed rod. CONSTITUTION:Aloe leaves are crushed to provide a liquid juice and thick malt syrup, sugar, etc., are added thereto. The resultant mixture is then boiled down to a viscosity so that the juice may thread. Edible flour (e.g. glutinous rice flour) is subsequently mixed and boiled down. The obtained mixture is then dropped onto dogtooth violet starch, extended to a shape of a rod and cut to a suitable length.
OBJECTIVE: To determine the incidence of secondary vertebral compression fracture (SVCF) after percutaneous vertebral augmentation (PVA) and its correlative risk factors, and to provide theoretical evidence for clinical practice.
METHODS: A retrospective analysis of 288 cases of PVA completed in our hospital from June 2020 to June 2023 was performed, and the patients were divided into the non-secondary vertebral compression fracture group (N-SVCF group) and the secondary vertebral compression fracture group (SVCF group) according to whether SVCF occurred during the postoperative follow-up review. Gender, age, body mass index (BMI), T value of bone mineral density (BMD-T), underlying diseases (hypertension, diabetes mellitus, coronary heart disease, chronic obstructive pulmonary disease), intravertebral vacuum cleft (IVC), amount of bone cement injected, classification of cement diffusion, anterior vertebral recovery ratio, local Cobb angle correction rate, leakage of bone cement into the intervertebral space, and fat infiltration rate (FIR) of paraspinal muscles were collected from the patients. The incidence and risk factors of SVCF after PVA were evaluated using univariate and multivariate logistic regression analysis, and the predictive value of the independent risk factors was evaluated using receiver operating characteristic curve (ROC) to determine the cut-off points at which they were meaningful for the development of SVCF.
RESULTS: In our study, the incidence of SVCF was 14.60% (42/288) in 288 patients who underwent PVA. Univariate analysis showed that age, BMI, fat infiltration rate of paraspinal muscles, cement leakage into the intervertebral space, unilateral/bilateral pedicle puncture approach and presence of IVC were statistically different between N-SVCF and SVCF (P < 0.05). Multifactorial regression analysis and ROC regression analysis revealed that the fat infiltration rate of the psoas major and erector spinae muscles, cement leakage into the intervertebral space, and IVC (P < 0.05) were risk factors for the incident of SVCF after PVA (P < 0.05). Psoas major (FIR) more than 5.490% and erector spinae (FIR) more than 52.413% had a high possibility of the occurrence of SVCF after PVA.
CONCLUSION: In this study, logistic regression combined with ROC curve analysis indicated that FIR of psoas major and erector spinae, cement leakage in the intervertebral space, and IVC were risk factors for the occurrence of SVCF after PVA. Psoas major (FIR) more than 5.490% and erector spinae (FIR) more than 52.413% had a high possibility of the occurrence of SVCF after PVA.