anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Chronic obstructive pulmonary disease (COPD) is a disease that leads to increased morbidity and mortality with severe pulmonary complications. The Global Burden of Disease studies have estimated that COPD is the third leading cause of death worldwide. The effects of COPD are not only limited to the lungs but also affects other organs and systems, causing loss of strength in the respiratory and peripheral muscles, which leading to a decreased capacity for exercise. Respiratory muscles are the skeletal muscles that can be trained based on the principles of exercise just like peripheral muscles. It is known that while doing exercise training in peripheral muscles, more muscle performance can be achieved by warming up those muscles before the loading phase. In this study, it is aimed to investigate the effect of inspiratory muscle warm-up (IMW) performed before inspiratory muscle training (IMT) in addition to general exercise training on respiratory functions, respiratory muscle strength, exercise capacity, perceived dyspnea intensity and health-related quality of life in patients with COPD.

Participants were randomly divided into two groups as the study group (IMW Group) and the control group (Standard IMT Group). The Standard IMT Group performed only IMT, while the IMW Group performed an IMW protocol for warming the inspiratory muscles before each IMT session. The IMT and IMW were applied using a threshold pressure loading device. The IMT applied as 30 breath repetitions at 60% of the maximal inspiratory pressure (MIP). The intensity of MIP adjusts by two weekly MIP measurements. The protocol of IMW consists of 2 sets of 30 breaths at 40% of MIP, with 1 min rest between sets, using a threshold inspiratory muscle trainer. Then the respiratory exercises and aerobic exercise program performed in both groups in each session. Aerobic exercise program; After 5 min of general body warming, applied 20 min with a load of 4-6 according to the modified Borg scale on the treadmill, finished with 5 min whole body cool-down. All program applied to 3 days a week for 8 weeks under the supervision of a physiotherapist and other days of the week without a supervisor. Demographic features questioned and recorded in the data recording form through a mutual interview in patients who meet the inclusion criteria. All patients evaluated before treatment and after treatment.
Phase 1 participants will help inform the cultural adaptation of the study design and materials. Phase 2 will enroll 10 dyads (20 individuals) of AN/AI people who smoke and a family member. Dyad participants will help beta-test the feasibility and acceptability of the financial incentives intervention.
The prevalence of COVID-19 critical illness varies across ethnicities, with recent studies suggesting that genetic factors may contribute to this variation. The aim of this study was to investigate natural selection signals of genes associated with critically-ill COVID-19 in sub-Saharan Africans. Severe COVID-19 SNPs were obtained from the HGI website. Selection signals were assessed in 661 sub-Sahara Africans from 1000 Genomes Project using integrated haplotype score (iHS), cross-population extended haplotype homozygosity (XP-EHH), and fixation index (Fst). Allele frequency trajectory analysis of ancient DNA samples were used to validate the existing of selection in sub-Sahara Africans. We also used Mendelian randomization to decipher the correlation between natural selection and critically-ill COVID-19. We identified that CCR3 exhibited significant natural selection signals in sub-Sahara Africans. Within the CCR3 gene, rs17217831-A showed both high iHS (Standardized iHS = 2) and high XP-EHH (Standardized XP-EHH = 2.5) in sub-Sahara Africans. Allele frequency trajectory of CCR3 rs17217831-A revealed natural selection occurring in the recent 1,500 years. Natural selection resulted in increased CCR3 expression in sub-Sahara Africans. Mendelian Randomization provided evidence that increased blood CCR3 expression and eosinophil counts lowered the risk of critically ill COVID-19. Our findings suggest that sub-Saharan Africans are resistant to critically ill COVID-19 due to natural selection and identify CCR3 as a potential novel therapeutic target.
Initiate Effient treatment as a single 60 mg oral loading dose and then continue at 10 mg orally once daily. Patients taking Effient should also take aspirin (75 mg to 325 mg) daily [see Drug Interactions (7.4) and Clinical Pharmacology (12.3)] . Effient may be administered with or without food [see Clinical Pharmacology (12.3) and Clinical Studies (14)] . 

Timing of Loading Dose

In the clinical trial that established the efficacy and safety of Effient, the loading dose of Effient was not administered until coronary anatomy was established in UA/NSTEMI patients and in STEMI patients presenting more than 12 hours after symptom onset. In STEMI patients presenting within 12 hours of symptom onset, the loading dose of Effient was administered at the time of diagnosis, although most received Effient at the time of PCI [see Clinical Studies (14)] . For the small fraction of patients that required urgent CABG after treatment with Effient, the risk of significant bleeding was substantial. 

Although it is generally recommended that antiplatelet therapy be administered promptly in the management of ACS because many cardiovascular events occur within hours of initial presentation, in a trial of 4033 NSTEMI patients, no clear benefit was observed when Effient loading dose was administered prior to diagnostic coronary angiography compared to at the time of PCI; however, risk of bleeding was increased with early administration in patients undergoing PCI or early CABG.

Dosing in Low Weight Patients

Compared to patients weighing ≥60 kg, patients weighing <60 kg have an increased exposure to the active metabolite of prasugrel and an increased risk of bleeding on a 10 mg once daily maintenance dose. Consider lowering the maintenance dose to 5 mg in patients <60 kg. The effectiveness and safety of the 5 mg dose have not been prospectively studied [see Warnings and Precautions (5.1), Adverse Reactions (6.1), and Clinical Pharmacology (12.3)] .
PURPOSE:To enable the measuring of a liquid-like human tissue factor quantitatively for a short time without being affected by other foreign manners by using two types of anti-human tissue factor monoclonal antibodies to recognize different antigen determinant parts separately. CONSTITUTION:A monoclonal antibody (first antibody) for a human tissue factor is immobilized on a proper insoluble carrier. Then, to avoid a non specific coupling of the insoluble carrier to a reagent or a test sample to be measured, the surface of the insoluble carrier is covered with a proper material. The insoluble carrier with a first antibody immobilized thereon thus obtained is kept in contact with a test sample at a temperature for a fixed time to react. Then, after a washing with a proper washing liquid, a solution of an antibody (second antibody) against to the human tissue factor labeled with a proper label substance is kept in contact with the human tissue factor bonded to a immobilized antibody on the insoluble carrier at a temperature for a fixed time to cause a reaction with the second antibody. The reactant is washed with a proper washing liquid and then, an amount of a label substance labeled on the second antibody on the insoluble carrier is measured. Then an amount of the human tissue factor is calculated from the value thereof.
In ecological contexts natural selection might favor individuals with a larger body mass to monopolize resources; however, there is wide variation in body mass within populations and potential factors. In this study, we evaluated whether fruit production limits body mass in one group of Sapajus apella, its effects on behavior, and whether there is a relationship between social status and body mass. We recorded activity patterns using focal follows (20 min), body mass (using a modified Ohaus scale), and community wide fruit production estimates (from 60 fruit traps). Body mass remained relatively stable during periods of food scarcity, but in periods of abundance most individuals gained weight, as indicated by their relative growth rates (RGR). Subordinate subadults showed the highest RGR, as expected by their age. In periods of high fruit production activities as traveling, grooming, and playing were more frequent than during fruit scarcity, suggesting energy maximization and potential energetic constraints. We found differences in behavior within the group, as the alpha male was observed feeding more frequently (and for longer periods of time), was more aggressive (e.g., feeding trees), and received more grooming than other individuals. In addition, the alpha male was 60% heavier than the group's average body mass. Our study supports the hypothesis that body weight gain is related to fruit abundance and that body size is associated with social dominance; however, large individuals (both males and females) seem to incur in high metabolic or reproductive costs, as they do not gain much weight as smaller individuals.
Hydrogels that expand volumetrically in response to a change in their environment (e.g., a change in pH or temperature) and their methods of manufacture and use. Generally, the hydrogels are prepared by forming a liquid reaction mixture that contains a) monomer(s) and/or polymer(s) at least portion(s) of which are sensitive to environmental changes (e.g., changes in pH or temperature), b) a crosslinker and c) a polymerization initiator. If desired, a porosigen may be incorporated into the liquid reaction mixture to create pores. After the hydrogel is formed, the porosigen is removed to create pores in the hydrogel. The hydrogel may also be treated to cause it to assume a non-expanded volume in which it remains until a change in its environment causes it to expand. These hydrogels may be prepared in many forms including pellets, filaments, and particles. Biomedical uses of these hydrogels include applications wherein the hydrogel is implanted in the body of a patient and an environmental condition at the implantation site causes the hydrogel to expand it situ.
In this condition, students receive weekly classes aimed to promote social-emotional development. In addition, they will receive 6 judo classes.
A method for filtered, real-time referral searches includes receiving, by an analysis engine, during a patient interaction between a patient and an operator, an identification of a clinical need. The analysis engine analyzes the identification of the clinical need and data associated with the patient to determine at least one patient requirement. The analysis engine identifies a plurality of medical providers as potential referrals for the patient. The analysis engine generates a question to ask the patient and modifies a user interface displayed to the operator, during the patient interaction, to include the generated question. The analysis engine receives input responsive to the generated question. The analysis engine accesses at least one state machine to filter the plurality of medical providers. The analysis engine modifies, during the patient interaction, the user interface, resulting in a display of an identification of each medical provider in the filtered set of medical providers.
The invention discloses a powdery granule for preventing and treating prostatitis, and relates to a Chinese patent medicine granule for treating male prostate verification. A powdery granule for preventing and treating prostatitis comprises pseudo-ginseng, maca, wolfberry fruit, tuber onion seed, sharpleaf galangal fruit, dogwood fruit, rhizoma polygonati and Chinese yam, wherein the components in parts by weight are as follows: 280g of pseudo-ginseng, 240g of maca, 260g of wolfberry fruit, 260g of tuber onion seed, 100g of sharpleaf galangal fruit, 260g of dogwood, 260g of rhizoma polygonati and 120g of Chinese yam. The pseudo-ginseng is 20 pseudo-ginseng, and is preferably produced in Yunnan province. The fructus Lycii is oven dried fructus Lycii. The semen Allii Tuberosi is processed by firing. The fructus alpiniae oxyphyllae is soaked in saline water and fried to be dry.
For each PWD, 1 non-disabled control person will be randomly chosen from the census list of the same enumeration area. Control will also be matched on age and sex.
The invention discloses a traditional Chinese medicine composition for invigorating stomach and relaxing bowels for animals. The composition comprises the components of sodium sulfate, sodium bicarbonate, sodium chloride and rheum officinale. The invention further discloses preparation of the traditional Chinese medicine composition. The preparation method comprises the following steps of: weighing 5-6% of sodium sulfate, 37-40% of sodium bicarbonate, 20-23% of sodium chloride and 34-35% of rheum officinale by weight based on the total weight percent of 100%; removing impurities for the weighed medicines; and crushing, airing, disinfecting by sunlight, and mixing and stirring to obtain the composition. The composition is free from any toxic and side effects. All raw materials are edible salts and plant roots. Animal by-products such as meat, milk and egg have no harmful residual toxin to a human body. The composition is further a green health-care medicine for animals and can be used as an additive. The composition has the effects of supplementing nutrition and improving metabolism, promoting nutrition absorption and utilization and accelerating growth.
PURPOSE:To provide a skin cosmetic containing a specific compound, free from side effect and skin irritation undesirable to human body, storable stably for a long period and having excellent effect to prevent the aging of skin such as the effect to improve the chapped skin, improve the corneous tissue, increase the rate of turn-over, etc. CONSTITUTION:The objective cosmetic contains at least one of the vitamin C-gamma-linoleic acid ester of formula I (R1-R4 are H or group of formula II; at least one of R1-R4 is not H) [e.g. ascorbyl 6-mono(gamma-linolate), ascorbyl 2,5-di(gamma-linolate), etc.]. The compound of formula I can be produced by reacting gamma-linoleyl chloride with vitamin C. The objective cosmetic can be produced by directly adding the compound to a cosmetic and subjecting the mixture to emulsification, mixing, dispersion, dissolution, etc. The amount of the compound in the composition is 0.01-10wt% based on the whole cosmetic composition. EFFECT:The cosmetic promotes the dermatic function, prevents the wrinkle of skin and gives fine and moisturized skin.
The (MST) condition will include a psychoeducation session on minority stress for all participants during the initial assessment session prior to their first psychotherapy session. Prior to attending each of the 12 psychotherapy sessions during their electronic assessment (filling out the OQ-45 on Qualtrics on a computer provided by the study team), patients will be prompted to report up to three minority stress experiences over the previous week in the survey tool (which the therapists will not see). They will be prompted by their therapist to discuss these experiences within their psychotherapy sessions (for example, "Would you like to discuss any of the minority stress experiences you've had over the week?").
The invention provides an intelligent coding method and system for Chinese surgery operation based on word segmentation network, comprising the following steps: step 1, acquiring a Chinese surgical operation name; step 2, adapting the Chinese operation name to a dynamic expansion word segmentation network, extracting key information from the Chinese operation name and forming key phrases by the extracted key information; and 3, adapting the key phrase and the phrase coding mapping table and outputting an unmatched result or an ICD code. Compared with the prior art, the invention has the following beneficial effects: 1. the standard codes of medical case data under heterogeneous conditions are unified, so that solid data standardization support is provided for the management decision of medical quality and medical insurance fund, and the gradual standardization and normalization of the clinical medical practice in China are promoted. 2. By the method, ICD coding can be automatically completed without manual participation, and the method has the advantages of high coding speed, low cost, high accuracy and the like. 3. Unified standard ICD coding.
Infectious diseases caused by pathogenic bacteria and viruses pose a significant threat to human life and well-being. The prompt identification of these pathogens, characterized by speed, accuracy, and efficiency, not only aids in the timely screening of infected individuals and the prevention of further transmission, but also facilitates the precise diagnosis and treatment of patients. Direct smear microscopy, microbial culture, nucleic acid-based polymerase chain reaction (PCR), and enzyme-linked immunosorbent assay (ELISA) based on microbial surface antigens or human serum antibodies, have made substantial contributions to the prevention and management of infectious diseases. Due to its shorter processing time, simple equipment requirements, and no need for professional and technical personnel, ELISA has inherent advantages over other methods for detecting pathogenic bacteria and viruses. Horseradish peroxidase mediated catalysis of substrate coloration is the key for the detection of target substances in ELISA. However, the variability, high cost, and environmental susceptibility of natural peroxidase greatly limit the application of ELISA in pathogen detection. Compared with natural enzymes, nanomaterials with enzyme-mimicking activity are inexpensive, highly environmentally stable, easy to store and mass producing, etc. Based on their peroxidase-like activities and unique physicochemical properties, nanomaterials can greatly improve the efficiency and ease of use of ELISA-like detection methods for pathogenic bacteria and viruses. This review introduces recent advances in the application of nanomaterials with peroxidase-like activity for the detection of pathogenic bacteria (both gram-negative bacteria and gram-positive bacteria) and viruses (both RNA viruses and DNA viruses). The emphasis is on the detection principle and the evaluation of effectiveness. The limitations and prospects for future translations are also discussed.
Cardiovascular disease is the leading cause of morbidity and mortality. The development of cardiovascular disease includes both genetic and epigenetic factors. Understanding their molecular and cellular mechanism is necessary to identify novel drug targets and treat the disease. Present in vitro and in vivo models of the disease do not mimic human pathophysiology, and obtaining the primary cells from the patients for the studies relevant to the cardiovascular and pulmonary system is difficult. Induced pluripotent stem cells (iPSCs) are derived from a person's blood cells and facilitate the discovery of cardiovascular disease mechanisms. The Investigators propose recruiting cardiovascular patients from diverse ethnic backgrounds and creating a rich clinical database using REDCap. Blood samples will be obtained from participants and used to create iPSCs. The participant will have DNA sequencing, and serum will be analyzed for protein biomarkers. The multi-omics data and reprogrammed iPSCs will be stored in the Cardiology and Critical Care (C3RP) laboratory at the Robarts Research Institute at Western University. The reprogrammed iPSCs can generate a limitless supply of cardiovascular tissue. Moreover, the iPSC-derived data will be correlated with clinical information, genetic sequencing, and protein biomarkers from serum analysis. The Investigators expect to create an iPSC biobank coupled with a rich clinical dataset, including genetic sequencing analysis and protein biomarkers that will enable the discovery of novel biomarkers and drug targets for cardiovascular disease.
In the first-stage, patterns of prenatal stress, fatigue, and sleep quality will be investigated by surveying 300 pregnant women who are over 23 weeks of gestation and screen for pregnant women with fatigue and poor sleep quality. In the second-stage, experts in obstetrics and TaiChi will be invited to modify a TaiChi exercise program. Thirty women who experience fatigue and poor sleep quality will be invited to practice the modified TaiChi exercise. Comments from those participants on the program will be used to refine the program and a DVD will be made. After the program is well-designed and recorded, participants recruited for the third-stage study will be randomly assigned to TaiChi or comparison group. They will be asked to complete questionnaires and give blood samples for biomarker tests when they are at 27-29, 31-33, and 35-37 weeks of gestation; in labor; and at 4-6 weeks postpartum. In addition to practice the exercise at home, participants in the TaiChi group will practice TaiChi in groups every month. In contrast, comparison group will be asked to keep on their usual daily activities, no other interventions will be introduced. Phone calls or postcard will be made or sent routinely to participants to ensure their long-term participation. Questionnaires used for the study include 10-item Perceived Stress Scale, Multidimensional Assessment of Fatigue Scale, and Pittsburgh Sleep Quality Index. Descriptive statistics, Pearson correlation, and generalized estimating equations will be applied to understand predictive effects of maternal stress, fatigue, sleep quality, and biomarkers on infant outcomes; and effects of modified TaiChi exercise on maternal stress, fatigue, sleep quality, biomarkers, and infant outcomes. In addition to develop a modified TaiChi exercise program suitable for pregnant women, the study anticipates that maternal stress, fatigue, and poor sleep quality can predict infant outcomes through immunologic pathway, and the modified TaiChi exercise can reduce maternal stress and fatigue, improve sleep quality, modulate biomarkers, and hence prevent adverse infant outcomes.