anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to an apoplexy first-aid kit for external treatment, and belongs to the field of medicines. Apoplexy belongs to a cardio cerebrovascular disease, and is currently recognized as the first killer harmful to human health. Apoplexy is mainly characterized in that apoplexy is fast in onset and fast in pathological change, and life is easy to threaten or sequela is easily left. The apoplexy first-aid kit is used by employing an external application (external treatment) method; and treatment is available in two or three minutes if the apoplexy first-aid kit is at hand. The disease is reversed when the application time is about 5 minutes, and the purposes of fast recovery, deterioration resistance and sequela resistance can be realized. The first-aid kit also can be used for recovery promotion and sequela resistance on the apoplexy disease at the middle and the later periods. The apoplexy first-aid kit has two key technologies: one is prescription and the other one is externally applied position.
Part A Cohort 3 involved healthy participants and was comprised of two treatment periods with a washout period of approximately 14 days between doses. Single dose 10mg LY3202626 given PO in Period 1 and 2. Period 1: Fasted 2: Fed.
The global burden of atrial fibrillation (AF) is high, and AF represents a major cause of morbidity, mortality and health-care expenditure. Thromboembolic stroke may be one of the fatal complications and oral anticoagulation has been the mainstay therapy for decades to mitigate stroke risk. However, in poor candidates for long-term anticoagulation (i.e. high bleeding risk, poor drug tolerance or adherence), non- pharmacological stroke prevention with percutaneous left atrial appendage occlusion (LAAO) is a considerable treatment option.

Occluders are implanted into the left atrial appendage (LAA) but they might dislocate and therefore embolize subsequently. In this case, surgical or percutaneous removal of the device may be indicated. Depending on the patient's status, implanting another device can be an alternative to returning to anticoagulation.
Betaine, known as trimethylglycine, is a non-toxic natural substance reported to affect cancer cell responses. This study delves into the impact of betaine on the survival, proliferation, and invasion of oral squamous cell carcinoma (OSCC) cells in vitro. Human OSCC cells (HSC-4 and HSC-7) were subjected to varying concentrations of betaine, and their viability and proliferation were assessed through colourimetric MTT and colony-forming unit assays. Cell cycle progression and cell apoptosis were also investigated using flow cytometry, while cell migration and invasion were examined using a transwell migration assay, and the mRNA expression was evaluated by a quantitative polymerase chain reaction. Finally, proteomic analysis was conducted through liquid chromatography-tandem mass spectrometry on the extracted protein component of the cells. Results indicate that betaine effectively suppressed OSCC proliferation and colony formation. It triggered early apoptosis without disrupting cell cycle progression, reduced cell migration, and inhibited invasion. Betaine exposure led to significantly decreased mRNA levels of MMP1, MMP2, and MMP9 while downregulating FN1, a gene linked to epithelial-to-mesenchymal transition. Proteomic analysis revealed 9240 differentially expressed up/downregulated proteins in cells treated with betaine. The significantly upregulated proteins were associated with ATP-binding cassette (ABC) transporters, while the down-regulated proteins were associated with G protein-coupled receptors (GPCR) ligand binding. In conclusion, betaine exhibits potent anti-cancer properties by attenuating OSCC cell proliferation and mitigating invasion. Exploring this natural product as an adjunct for managing oral squamous cell carcinoma shows promise, although further investigations are needed to fully elucidate its functionality.
Mental disorders are intricate and multifaceted and encompass social, economic, environmental, and biological factors. This study aimed to explore the potential association between vitamin D deficiency and anxiety and depression symptoms in adults, considering the role of the vitamin D receptor gene polymorphism FokI (rs2228570). This was a population-based cross-sectional study with stratified and cluster sampling, evaluating anxiety symptoms (AS) and depression symptoms (DS) in 1637 adults. Vitamin D levels were measured using electrochemiluminescence and were considered deficient when < 20 ng/mL in a healthy population or < 30 ng/mL in at-risk groups. Genotyping was performed using real-time polymerase chain reaction with TaqMan probes. The prevalence rates of AS, DS, and vitamin D deficiency were 23.5%, 15.8%, and 30.9%, respectively. No direct association was observed between vitamin D deficiency and AS or DS. However, interaction analysis revealed a combined effect of vitamin D deficiency and FokI for DS but not for AS. Individuals with vitamin deficiency and one or two copies of the altered allele of the FokI exhibited a higher prevalence of DS than individuals homozygous for the wild-type allele and vitamin D sufficiency. The interaction between vitamin D deficiency and the FokI polymorphism was associated with DS.
PURPOSE: A method for preparing a three dimensional stem cell hybrid spheroid and a cell therapeutic agent containing the hybrid are provided to enhance differentiation ability into vascular cells and stem cell survival rate. CONSTITUTION: A method for preparing three-dimensional stem cell hybrid spheroid comprise: a step of shaking stem cells to form a primary spheroid; a step of shaking the primary spheroid together with a support cell and forming a secondary spheroid; and a step of adding niche cells to the secondary spheroid. The stem cells are a mesenchymal stem cell, vascular endothelial precursor cell, embryonic stem cell, myobalst, or cardiac stem cell. The support cell is a mesenchymal stem cell, chondrocyte, or myoblast. The niche cells are a mesenchymal stem cell, chondrocyte, or myoblast. A cell therapeutic agent for treating ischemic diseases contains the hybrid spheroid. An immunocompetent cell therapeutic agent contains the hybrid spheroid.
The core intervention will last 5 months. Nutrition content: Mediterranean diet education, social support, self-regulation techniques, and environmental support. Physical activity content: education, guidance in starting a routine, and a walking program with pedometers, weekly physical activity tips and step goals. Emotion regulation content: based on Dialectical Behavior Therapy adapted to binge eating disorders and other ER sources, emphasizing identifying emotions, recognizing the causes of emotions, accepting and tolerating negative emotions, effective self-support and self-compassion, and the ability to manage situations that elicit negative emotions, as well as re-appraisal skills, which are identified as particularly influential on eating behaviors.
Postoperative pulmonary complications account for \>50% of all adverse postoperative events and are more costly and carry greater comorbidity than cardiac complications. Much research has been performed to identify potential risk reduction strategies for PPCs. Until recently all of these focused on intraoperative and postoperative interventions, including lung-protective mechanical ventilation, lung expansion techniques, and use of regional anesthesia and analgesia. In the last few years several studies have investigated the potential role of preoperative interventions to improve respiratory status. These studies have demonstrated benefit from preoperative inspiratory muscle training (IMT). A recent systematic review found that any preoperative intervention, such as education, IMT, exercise training or relaxation reduced PPC rates. However, these studies have focused on cardiothoracic and abdominal surgery, and almost all have utilized respiratory therapist-directed interventions. Likely due to the additional costs and difficulty of arranging respiratory therapy on an outpatient basis, this promising new risk mitigation strategy has yet to be adopted on a large scale. Incentive spirometry devices offer a potentially easier and less costly preoperative respiratory intervention. Incentive spirometers are a drug-free, easy to use, hand-held device that promotes deep breathing and respiratory muscle strength by providing visual feedback during sustained inhalation. It opens weak or collapsed airways to mobilize and assist mucociliary clearance to the upper airways where it can be coughed out. This study evaluates the hypothesis that providing preoperative, patient self-directed respiratory therapy with use of an incentive spirometry device will reduce the incidence of PPCs in patients with increased pulmonary risk undergoing any major, non-cardiothoracic surgery with general anesthesia.
The present disclosure provides population-based and non-population-based classifiers that classify patients and cancers. The disclosed population-based classifier integrates markers, i.e., overall scores associated with the expression of genes in a particular genetic set. Non-population-based classifiers are generated using machine learning techniques (e.g., regression, random forest, or ANN). Each type of classifier stratifies patients and cancers as biomarker positive or biomarker negative according to the Tumor Microenvironment (TME) and then guides treatment decisions by the presence/absence of a particular TME. Also provided are methods of treating a subject, e.g., a human subject, suffering from cancer, comprising administering a particular therapy based on the classification of the TME of the cancer according to the disclosed classifier. Also provided are personalized therapies that can be administered to subjects having cancers classified as a particular TME, as well as a gene set that can be used to identify human subjects having cancers amenable to treatment with a particular therapeutic agent.
PROBLEM TO BE SOLVED: To obtain disintegrable particles which are disintegrated in an aq. soln. contg. a water-soluble salt when the concn. of the salt is decreased by binding and agglomerating water-soluble primary particles with a water-soluble binder and to obtain a detergent compsn. which exhibits a high detergency, an excellent feeling in use, and a very good rinsability by compounding the disintegrable particles, a water-soluble salt, a surfactant, and water. SOLUTION: Water-soluble primary particles having an average size of 70 μm or lower are bound and agglomerated with 0.5-30 wt.% water-soluble binder to give disintegrable particles having an average size of 100-800 μm. Pref., the disintegrable particles disintegrate in an aq. soln. contg. lower than 1.5 wt.% water-soluble salt and the disintegration ratio is 80 vol.% or higher. A detergent compsn. contg. 1-25 wt.% disintegrable particles. an inorg. salt in a concn. of 1.5 wt.% or higher but lower than the saturation concn., a surfactant, and water exhibits disintegration of at least 80 vol.% of the disintegrable particles in cleaning and rinsing an object to be cleaned.
A mode of a polypeptide according to the present invention exhibits a fluorescence property, and has (1) an amino acid sequence represented by SEQ ID NO. 1 or NO. 2, (2) an amino acid sequence represented by SEQ ID NO. 1 or NO. 2 in which amino acid sequence 1 to 34 amino acids have been replaced or otherwise modified, (3) a sequence identity of 85% or more with respect to the amino acid sequence represented by SEQ ID NO. 1 or NO. 2, or (4) an amino acid sequence encoded by a polynucleotide that hybridizes under a stringent condition with a polynucleotide having a sequence complementary to a polynucleotide that encodes the polypeptide defined in (1).
PURPOSE:To obtain the titled composition consisting of a polypeptide, a specific absorption promoter and a water-absorbing solid base. CONSTITUTION:A powdery composition for nasotracheal administration containing a physiologically active polypeptide (e.g. peptide hormone such as calcitonin, physiologically active protein, enzyme protein, vaccine, etc.), an ascorbic acid (e.g. ascorbic acid, erysorbic acid, etc.) and a basic amino acid (e.g. arginine, histidine, lysine, etc.) and/or a salt thereof as an absorption promoter and a water-absorbing solid base (e.g. water-absorbing and slightly water- soluble cellulose, starch, crosslinked vinyl polymer or gum) suitable for application to nasal mucosa. The preferable concentrations of the ascorbic acid and the amino acid are 0.1-20wt% and 0.1-20wt% based on sum of the composition, respectively. The composition can be directly made into powder in unit administration form.
Patients to be included in this study will be pre-operatively staged according to American Joint Committee on Cancer (AJCC) 7th edition, International Union against cancer ( which uses TNM staging ) as stage I , stage II of breast carcinoma. Twenty patients of histologically proven post lumpectomy/mastectomy cases of carcinoma breast suitable for radiotherapy will be enrolled in this study. Patients would be evaluated at the Department of Radiotherapy PGIMER, Chandigarh by doing a thorough clinical examination followed by routine investigations which will include hemogram, liver function tests, kidney function tests, chest X-ray. Patients will be treated by standard rectangular tangential fields.The study will include 20 patients with breast cancer post mastectomy or after breast conservative surgery to be treated with a radiotherapy dose of 34Gy in 10 fractions over 2 weeks followed by a boost of 10Gy/5#/1wk in cases with intact breast. Acute toxicity will be assessed using a RTOG grading system. This will be carried out weekly during radiotherapy and for 4 weeks after treatment. If symptoms persist the patients will be assessed weekly until their reaction settles to RTOG grade 1 or less (Annexure I).

Statistical analyses The principle end point of the study is an analysis of acute toxicities, cosmetic score analysis. Skin, subcutaneous toxicity and cosmetic assessment will be done before treatment and then in regular follow up of the study. Chi-square test will be used to compare radiation toxicity parameters. Descriptive statistics including mean and standard deviation will be obtained for all variables. p values of \<0.05 will be taken as significant. All tests would be performed using SPSS (Statistical Package for the Social Sciences) v.12.0.
Research into the molecular basis of disease trajectory and Long-COVID is important to get insights toward underlying pathophysiological processes. The objective of this study was to investigate inflammation-mediated changes of metabolism in patients with acute COVID-19 infection and throughout a one-year follow up period. The study enrolled 34 patients with moderate to severe COVID-19 infection admitted to the University Clinic of Innsbruck in early 2020. The dynamics of multiple laboratory parameters (including inflammatory markers [C-reactive protein (CRP), interleukin-6 (IL-6), neopterin] as well as amino acids [tryptophan (Trp), phenylalanine (Phe) and tyrosine (Tyr)], and parameters of iron and vitamin B metabolism) was related to disease severity and patients' physical performance. Also, symptom load during acute illness and at approximately 60 days (FU1), and one year after symptom onset (FU2) were monitored and related with changes of the investigated laboratory parameters: During acute infection many investigated laboratory parameters were elevated (e.g., inflammatory markers, ferritin, kynurenine, phenylalanine) and enhanced tryptophan catabolism and phenylalanine accumulation were found. At FU2 nearly all laboratory markers had declined back to reference ranges. However, kynurenine/tryptophan ratio (Kyn/Trp) and the phenylalanine/tyrosine ratio (Phe/Tyr) were still exceeding the 95th percentile of healthy controls in about two thirds of our cohort at FU2. Lower tryptophan concentrations were associated with B vitamin availability (during acute infection and at FU1), patients with lower vitamin B12 levels at FU1 had a prolonged and more severe impairment of their physical functioning ability. Patients who had fully recovered (ECOG 0) presented with higher concentrations of iron parameters (ferritin, hepcidin, transferrin) and amino acids (phenylalanine, tyrosine) at FU2 compared to patients with restricted ability to work. Persistent symptoms at FU2 were tendentially associated with IFN-γ related parameters. Women were affected by long-term symptoms more frequently. Conclusively, inflammation-mediated biochemical changes appear to be related to symptoms of patients with acute and Long Covid.
Breast milk from HIV infected and HIV uninfected women who are breastfeeding is collected at 2 days, 2 weeks, 2 months, and 5 months post-partum. This breast milk will be compared for in vitro functional quality of immunoglobulins to selected diarrheal and respiratory pathogens.
A graphic user interface as well as related methods and logic for a DICOM transfer configuration are provided. For example, a first image object corresponding to an origin node is provided. A second image object corresponding to a destination node is provided. The second image object includes an indicator associated with a DICOM transfer. At least one link image object is between the first image object and the second image object. The link image object is indicative of a potential DICOM transfer. The first, second, and link image objects are displayed in a user interface. The potential DICOM transfer is operable to be configured via the user interface.
Hydatid cysts, caused by Echinococcus species, are zoonotic diseases frequently observed in endemic regions worldwide, including Turkey. It is most commonly localized in the liver, followed by the lungs. Anaphylaxis and peritonitis, which develop after cyst rupture, are the most significant complications observed in these patients. Early diagnosis and prompt surgical intervention are extremely important. This study presented an extremely rare case of a hepatic hydatid cyst ruptured into the thorax, which may have high morbidity and mortality. A 24-year-old male patient presented to our emergency department with cough, dyspnea, fever, and allergy symptoms. He had a history of hepatic hydatid cyst surgery 5 years ago. Physical examination revealed urticarial lesions on the skin. The body temperature was 39 °C, and the pulse rate was 120 beats/min. Laboratory tests revealed leukocytosis and elevated C-reactive protein. Contrast-enhanced thoracic and abdominal computed tomography was performed. Diagnostic tests revealed that the patient had a ruptured hepatic hydatid cyst in the right thoracic cavity; hence, he was scheduled for emergency surgery. Laparotomy was performed via a right subcostal incision, and the ruptured cyst was located. It was understood that this cyst had fistulized into the diaphragm during a chronic process and subsequently ruptured acutely into the thorax. Partial cystectomy was performed for a ruptured liver cyst. The diaphragm was repaired, and catheters were placed in the thorax and abdomen for drainage. There were no other postoperative complications. Rupture of hydatid cyst disease is frequently observed in endemic regions. The rupture of a hepatic hydatid cyst into the thorax is an extremely rare event. In patients presenting with pulmonary symptoms who have a history of hepatic hydatid cyst surgery, the abdomen should always be thoroughly evaluated, and emergency surgery should be performed if required.
The invention discloses a Chinese medicine preparation for treating biliary calculi, belonging to the field of traditional Chinese medicines, composed of 15 parts of capillary wormwood herb, 30 parts of indigowoad root, 15 parts of dandelion, 6 parts of cortex magnoliae officinalis, 9 parts of cortex phellodendri, 9 parts of scutellaria, 9 parts of weathered sodium sulfate (molten), 9 parts of raw rhubarb (added later), 9 parts of radix bupleuri, 9 parts of scirpus fluviatilis and 9 parts of zedoary by weight. Except the weathered sodium sulfate and the raw rhubarb, other materials are put into a ceramic casserole, cold water is added to cover the material surface, after full soaking, the cover is put on the ceramic casserole, the materials are boiled with big fire and then with soft fire, after 20 minutes, the raw rhubarb is put into the casserole and boiled for 5 minutes, dregs are removed, the weathered sodium sulfate is put into the liquor, and then the liquor is boiled slightly with soft fire. Biliary calculi is resulted from moist heat, stagnated fire and bile torture. The technical problems to be solved are moist heat, stagnated fire and calculi; the technical solution is drug application and formula composition. The Chinese medicine preparation has effects of clearing away heat and promoting diuresis, dispersing the liver and discharging the bile, dissolving biliary calculi, melting biliary calculi and eliminating biliary calculi. The Chinese medicine preparation is used for treating biliary calculi.
Gastric cancer (GC) is a leading cause of cancer-related mortality and is characterized by significant heterogeneity, highlighting the need for further studies aimed at personalized treatment strategies. Tumor angiogenesis is critical for tumor development and metastasis, yet its role in molecular subtyping and prognosis prediction remains underexplored. This study aims to identify angiogenesis-related subtypes and develop a prognostic model for GC patients. Using data from The Cancer Genome Atlas (TCGA), we performed consensus cluster analysis on differentially expressed angiogenesis-related genes (ARGs), identifying two patient subtypes with distinct survival outcomes. Differentially expressed genes between the subtypes were analyzed via Cox and LASSO regression, leading to the establishment of a subtype-based prognostic model using a machine learning algorithm. Patients were classified into high- and low-risk groups based on the risk score. Validation was performed using independent datasets (ICGC and GSE15459). We utilized a deconvolution algorithm to investigate the tumor immune microenvironment in different risk groups and conducted analyses on genetic profiling, sensitivity and combination of anti-tumor drug. Our study identified ten prognostic signature genes, enabling the calculation of a risk score to predict prognosis and overall survival. This provides critical data for stratified diagnosis and treatment upon patient admission, monitoring disease progression throughout the entire course, evaluating immunotherapy efficacy, and selecting personalized medications for GC patients.
Prophylactic immunostimulant combination comprises a daily dose of an alcoholic extract of Eleutherococcus senticosus in blackcurrant juice enriched with daily requirements of magnesium aspartate, potassium aspartate and other important bioelements. The blackcurrant juice may be replaced by similar natural juices, e.g. elder, cherry, grape or sea buckthorn, which are rich in trace elements and vitamin C. USE/ADVANTAGE - The immunostimulant contains magnesium and potassium in a form which is easily transported into cells and is of wider applicability than the combination prod. described in DE 4108951. In partic., the immunostimulant improves the economical utilisation of bodily energy reserves, delaying the onset of fatigue and preventing or eliminating muscular aches and cramps, amyosthenia, gastro-intestinal disorders, heart compliants, ready fatigability, apathy and kidney function disorders. It can be taken e.g. by performance athletes, partic. those engaged in endurance and multi-discipline sports, aged and sick persons in order to increase mental and physical efficiency and to repress susceptibility to illnesses, such as colds and bacterial and viral infections, in a natural manner. The immunostimulant may be provided in the form of a "fitness drink" taken at breakfast or in the form of a concentrate from which such a drink can be prepared daily.