anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Physiological similarities exist between the anesthetized state and sleep. Pathways within the brain controlling sleep and wakefulness are also affected by anesthesia. One significant difference between the states of anesthesia and sleep is the ability to respond whenever a relatively mild stimulus is applied, e.g. verbal command or gently shaking. Interestingly, this feature of arousability is seen when dexmedetomidine is used for sedation but is absent when alternative intravenous anesthetic agents, e.g. propofol, are used to provide similar degree of sedation. Recent studies have shown that dexmedetomidine acts on receptors located within the locus ceruleus, which are responsible for both sleep and anesthesia.

During a recent study volunteers received an infusion of dexmedetomidine during the afternoon prior to remaining under study conditions for the duration of the night. The study was not designed to measure sleep but anecdotal reporting from the participants suggested that they were able to resume their normal day's activities whilst the subject receiving placebo felt extremely fatigued from lack of sleep. This prompted the establishment of a pilot study to determine if dexmedetomidine could provide restorative sleep to people under disturbed sleep conditions i.e. postoperative patients.
OBJECTIVE: The purpose of this study was to explore the optimal timing and associated risks of pediatric spinal deformity surgery during the coronavirus disease 2019 (COVID-19) pandemic.
METHODS: All consecutive surgical cases for spinal deformity between September 2022 and May 2023 were included. The population was divided into several categories according to the time from diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to the day of surgery. Postoperative complications were analyzed using logistic regression, and we simultaneously showed the results from the crude model, minimally adjusted model, and fully adjusted model.
RESULTS: A total of 81 consecutive patients were enrolled. In the fully adjusted model, compared with pre-COVID-19 patients, peri-COVID-19 patients had a 4.5-fold increased risk of postoperative complications (odds ratio = 5.5, 95% confidence interval 1.1-27.2, P = 0.037), early post-COVID-19 patients had a 2.3-fold increased risk (odds ratio= 3.3, 95% confidence interval 0.7-16.1, P = 0.133), and late post-COVID-19 patients were at essentially equal risk. In asymptomatic population, early post-COVID-19 patients and late post-COVID-19 patients appeared to be at equal risk compared with pre-COVID-19 patients. For patients with persistent symptoms, is necessary to wait at least 8 weeks or even longer after SARS-CoV-2 infection. Interaction tests demonstrated that the effect of the timing of surgery on postoperative complications significantly differed in populations with different symptoms.
CONCLUSIONS: Surgery for pediatric spinal deformity should be postponed until 8 weeks after SARS-CoV-2 infection in cases with COVID-19-related symptoms within 2 weeks prior to surgery; whereas, for those who are asymptomatic within 2 weeks prior to surgery, an interval of 4 weeks seemed to be sufficient.
The effectiveness of Paroxetine HCL CR for the treatment of Premenstrual Dysphoric Disorder (PMDD) utilizing a continuous dosing regimen has been established in 2 placebo‑controlled trials in female patients ages 18 to 46 (Studies 8 and 9 [N=672]). Patients in these trials met DSM‑IV criteria for PMDD. Of 1,030 patients including Study 10, who were treated with daily doses of Paroxetine HCL CR 12.5 or 25 mg/day, or placebo continuously throughout the menstrual cycle for a period of 3 menstrual cycles, the mean duration of the PMDD symptoms was approximately 11 ± 7 years. Patients on systemic hormonal contraceptives were excluded from these trials. Therefore, the efficacy of Paroxetine HCL CR in combination with systemic (including oral) hormonal contraceptives for the continuous daily treatment of PMDD is unknown. 

The VAS score is a patient‑rated instrument that mirrors the diagnostic criteria of PMDD as identified in the DSM‑IV, and includes assessments for mood, physical symptoms, and other symptoms associated with PMDD. In Studies 8 and 9, 12.5 mg/day and 25 mg/day of Paroxetine HCL CR were statistically significantly more effective than placebo as measured by change from baseline to Month 3 on the luteal phase VAS score. 

In an additional study employing luteal phase dosing (Study 11), patients (N = 366) were treated for the 2 weeks prior to the onset of menses with 12.5 or 25 mg/day of Paroxetine HCL CR or placebo for a period of 3 months. In this trial,12.5 mg/day and 25 mg/day of Paroxetine HCL CR, as luteal phase dosing, was statistically significantly more effective than placebo as measured by change from baseline to luteal phase VAS score at Month 3.

There is insufficient information to determine the effect of race or age on outcome in Studies 8, 9, 10, and 11.
The follicular environment is primarily influenced by the type of gonadotropin the follicle is exposed to during the follicular phase. The role of gonadotropins has been especially important in improving the efficiency of in vitro fertilization. Several studies comparing the use of human menopausal gonadotropin (hMG) with recombinant follicle-stimulating hormone (rFSH) have found significant differences in the endocrinological profile and the follicular dynamics. These differences have been related to the human chorionic gonadotropin (hCG)-driven luteinizing hormone (LH) activity added to hMG. Moreover, differences in the proportion of acid residues in FSH molecules should be considered.

On the other hand, the main physiological regulatory hormones of follicular survival are the gonadotropins. Suppression of serum gonadotropins leads to massive apoptosis of granulosa cells in developing follicles resulting in atresia; whereas, gonadotropin treatment of early antral and pre-ovulatory follicles prevents this unplanned apoptosis. However, studies using cultured rat granulosa cells have shown that treatments with FSH or LH/hCG are ineffective in preventing spontaneous apoptosis, suggesting neighboring theca cells and local factors produced in the ovary are important for regulation of follicle growth and atresia.
PURPOSE: To provide a hair-tonic and hair-growing agent having excellent hair- tonic hair-growing effect and hair-falling prevention effect and keeping high safety over a long period. CONSTITUTION: This hair-tonic and hair-growing agent contains extract of OUGI (root of Astragalus huantchy). The OUGI extract is preferably used usually in the form dissolved in water or a solvent such as water-lower alcohol mixture and the amount of the extract is preferably 0.001-10wt.%, especially 0.03-3wt.% in dry basis in the hair-tonic and hair-growing agent. The OUGI extract may be used singly or, for further improving the hair-growing effect, it may be compounded with 0.001-5wt.%, especially 0.01-3wt.% of a component selected from a blood circulation accelerator, antimicrobial agent, keratolytic agent, antiseborrheic agent, local stimulant, anti-inflammatory agent, humectant, anti-male hormone agent and hair follicle activator.  The blood circulation accelerator is e.g. extract of Swertia japonica, vitamin E, cepharanthine or phthalides and the antimicrobial agent is e.g. octopyrox, benzalkonium chloride or salicylic acid.
INTRODUCTION: Despite advancements in Cytomegalovirus (CMV) management, its impact on graft function, mortality, and cardiovascular (CV) health of organ transplant recipients (OTR) remains a significant concern. We investigated the association between CMV infection and CV events (CVE) in organ (other than heart) transplant recipients.
METHODS: We conducted a comprehensive literature search in PubMed and EMBASE, including studies that reported on CMV infection or disease and post-transplantation CVE. Studies of heart transplant recipients were excluded.
RESULTS: We screened 3875 abstracts and 12 clinical studies were included in the final analysis, mainly in kidney and liver transplant recipients. A significant association was observed between CMV infection and an increased risk of CVE, with a pooled unadjusted hazard ratio (HR) of 1.99 (95% Confidence Intervals [CI] 1.45-2.73) for CMV infection and 1.59 (95% CI 1.21-2.10) for CMV disease. Pooled adjusted HR were 2.17 (95% CI 1.47-3.20) and 1.77 (95% CI 0.83-3.76), respectively. Heterogeneity was low (I2 = 0%) for CMV infection, suggesting consistent association across studies, and moderate-to-high for CMVdisease (I2 = 50% for unadjusted, 53% for adjusted HR).
DISCUSSION: We found a significant association between CMV infection and CV risk in abdominal OTR, underscoring the importance of proactive CMV surveillance and early treatment. Future research should aim for more standardized methodologies to fully elucidate the relationship between CMV and CV outcomes, potentially informing novel preventive and therapeutic strategies that could benefit the CV health of OTR.
The recommended dose of Kepivance is 60 mcg/kg/day, administered as an intravenous bolus injection for 3 consecutive days before and 3 consecutive days after myelotoxic therapy, for a total of 6 doses. The recommended dose of Kepivance is 60 mcg/kg/day, administered as an intravenous bolus injection for 3 consecutive days before and 3 consecutive days after myelotoxic therapy, for a total of 6 doses. 

Administer the first 3 doses prior to myelotoxic therapy. Administer the third dose 24 to 48 hours prior to beginning myelotoxic therapy Administer the first 3 doses prior to myelotoxic therapy. Administer the third dose 24 to 48 hours prior to beginning myelotoxic therapy [see Drug Interactions ( 7)]. 

Administer the last 3 doses after myelotoxic therapy is complete; administer the first of these doses on the day of hematopoietic stem cell infusion after the infusion is completed, and at least 7 days after the most recent administration of Kepivance [see Drug Interactions ( 7)].
BACKGROUND: About half of the world's populations are infected with Helicobacter pylori, which may create atherogenic lipid profiles and contribute to atherosclerosis and related cardiovascular disease. Furthermore, it has been connected to hematological symptoms like anemia. Even though the high prevalence of H.pylori and its associated complications, including cardiovascular disease and anemia, in Ethiopia, there is little data regarding the risk factors associated with H.pylori infection, such as hematologic parameters, electrolyte imbalances, and lipid profiles.
METHODS: A comparative cross-sectional study design with a consecutive sampling technique was employed at Jimma Medical Center among 108 dyspeptic patients. Five (5) ml of blood samples were collected from each participant, and serum was extracted and analyzed using a COBAS 6000 core for the lipid and electrolyte, and whole blood was used with a SYSMEX XN 550 to determine hematological parameters. Data were entered in to Epi-data version 4.6 and exported to SPSS version 25 for analysis. Simple descriptive statistics and chi-square test were used to present the socio-demographic characteristics of the study subjects. Student t-test was used for data comparison and p-value < 0.05 was considered statistically significant.
RESULTS: H.pylori infected patients had significantly decreased levels of red blood cell count (p = 0.002), hemoglobin (p = 0.012), mean corpuscular hemoglobin concentration (p < 0.001), platelet count (p = 0.001), and sodium level (p = 0.006) when compared to the uninfected group. However, total cholesterol (p = 0.001), and low density lipoprotein (p = 0.021) were increased in H.pylori infected patients when compared to the uninfected group.
CONCLUSIONS: This study revealed that H.pylori infection can cause derangements of hematologic parameters, electrolyte imbalances, and alterations of lipid parameters which considered as risk factors for anemia and cardiovascular diseases.
An inflammatory cytokine is disclosed which has been isolated from cells that have been incubated with a stimulator material. The inflammatory cytokine comprises a protein that is capable of binding to heparin, inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously and having potent in vitro chemotactic activity while inducing little or no in vitro chemokinesis in polymorphonuclear cells, while lacking the ability to suppress the activity of the anabolic enzyme lipoprotein lipase, cause the cytotoxicity of cachectin/TNF-sensitive cells, stimulate the blastogenesis of endotoxin-resistant C3H/HeJ thymocytes, or induce the production of cachectin/TNF by primary thioglycollate-elicited mouse macrophage cells. A particular inflammatory cytokine has been isolated and its cDNA has been sequenced. The sequence predicts a cDNA of 74 amino acids in length and a molecular weight of 7,908. Diagnostic and therapeutic utilities are proposed, and testing procedures, materials in kit form, recombinant materials and procedures, and pharmaceutical compositions are likewise set forth. <IMAGE>
The invention relates to new quinazolinone derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. The invention relates to new quinazolinone derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer. This invention relates to toys (10, 20, 30, 40). In particular, although not exclusively, this invention relates to toys such as dolls (10, 20, 30) that interact with each other. One aspect of this invention relates to an authoring tool for creating themed data for toys, comprising means (2000) for receiving content in the form of a scripted dialogue relating to a particular theme; means for processing said content to generate a set of instructions for operating said toy within said particular theme; and means for outputting said set of instructions. This invention also relates to an H-bridge circuit arrangement (920), which is particularly applicable, but by no means limited, for use in amplifiers for battery-powered devices, for which polarity protection is desired. The invention also relates to detecting (960, 980) potentially corrupt or otherwise invalid signals. The signals are signals such as audio signals. This invention also relates to an audio coding scheme (1000, 1040).
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to dentistry, and can be applied for treatment and prevention of jaw alveolitis. For this purpose fragments and parts of non-viable bone tissue are removed from alveolus of removed tooth. Then alveolus is filled with sterile collagen sponge, soaked in prepared ex tempore bifidumbacterin. ^ EFFECT: invention allows increasing of efficiency and reducing treatment and prevention terms due to normalisation of micro flora in alveolus of removed tooth, as well as anti-inflammatory action of medication. ^ 1 ex
Urinary incontinence, characterized by involuntary loss of urine (International Continence Society), is a serious social and health issue whose incidence is increasing. Urinary incontinence refers to a condition in which urine is inadvertently excreted from the bladder to the urethra, usually due to a disability or an incapacity to control the bladder and urethral sphincter. Urinary incontinence is a common complaint in women, which can have an important influence on the quality of her life. Its prevalence is between 10% and 40%, and the most common form is stress urinary incontinence. Age, body mass index, genetic factors, pregnancy and delivery, and a history of hysterectomy, smoking, race, constipation and menopause have been considered as its risk factors.

A Randomized controlled trial will be conducted to determine the effects of Kegel exercises with and without whole body vibration on pelvic floor muscle strength, incontinence intensity and quality of life in patients with stress urinary incontinence. A sample size of 26 SUI women's will be taken, Data will be collected from the private clinical setups of Lahore by using IQOL, Urinary intensity questionnaire: Urinary Incontinence Questionnaires (King's Health Questionnaire (KHQ), Muscle strength: PERFECT scale and SF-36 Questionnaire. A written consent form will be taken from participants meeting inclusion criteria and will be randomly allocated into two groups of equal members. One group undergoing WBVT and Conservative treatment and other group with Pelvic floor muscle training with conservative treatment. The interventions will be provided for 30 minutes for 3-4 D/Week for 4 months. All participants in both groups will be evaluated before and after the treatment programs. Total duration of study will be 8 months after the approval of synopsis. Data will be analyzed by using SPSS 26.

KEY WORDS: Pelvic floor muscle strength, Quality of life, Stress urinary incontinence, Whole body vibration.
People with special needs, like those with Down syndrome, Parkinson disease, or dementia, frequently suffer from orofacial pain conditions and dysfunction of the masticatory system. However, the accurate assessment of orofacial pain and dysfunction in such individuals is challenging. In this review, the complexities of assessing and managing orofacial pain and dysfunction in special needs populations will be described, along with their comorbid orofacial conditions like impaired oral health, salivary problems, and movement disorders of the masticatory system. In addition, the importance of maintaining or restoring a good quality of life will be highlighted, while the urgent need for oral care as part of palliative care will be stressed as well. To accomplish all this, interdisciplinary collaboration between medical doctors and dentists should be promoted in research, education, prevention, and care provision. Therefore, this review focuses specifically on this important topic.
FIELD: medicine.SUBSTANCE: invention relates to medicine. Apparatus for detecting thrombocyte adhesion kinetics comprises a flow unit, an optical unit and an electronic computing unit. Device is equipped with housing, in which flowing, optical and electronic computation units are installed, as well as metering pump installed in housing and receiving mechanism with servo drive. Receiving mechanism includes base, in which optical unit is located, and cover installed on guides and connected with servo drive with possibility of cover lifting and its lowering and pressing flow chamber to optical unit prism. Body is provided with a socket for placing a test tube with biological fluid, and the metering pump is connected by one tube with a biological fluid reservoir, and is also connected to another tube for pumping biological fluid from the above test tube. Electronic computing unit is connected to circulation pump with possibility to control flow rate of biological fluid, is also connected with dosing pump and with optical unit with possibility to control extraction of biological fluid from test tube, as well as control of laser operation and processing of results detected by photodetectors.EFFECT: device is completely autonomous and excludes manual operations for sampling and accurate installation of flow chamber relative to laser radiation source and photodetectors.3 cl, 8 dwg
The invention provides an Aspergillus oceanic source oxaanthraquinone compound, a preparation method thereof and application of the Aspergillus oceanic source oxaanthraquinone compound in preparation of an anti-tumor agent. The Aspergillus oceanic is an Aspergillus ( Aspergillus  sp.) ZA-01 strain, the preservation date is January 25, 2018, the preservation number is CGMCC No.15270, the preservation unit is the China general microbiological culture Collection center, and the preservation unit address is No. 3, No.1 yard, Beichen West road, Chaoyang district, Beijing. The structural formula of the compound is selected from formulas 1-6, the Aspergillus ( Aspergillus  sp.) ZA-01 strain is cultured through fermentation, and the compound is separated from a fermentation product. It is verified that the compound has high inhibitory activity on tumor cells, can be used as an anti-tumor drug and has broad application prospects.
PURPOSE:To obtain an easily usable homogeneous gel paste useful as an agent for treating peripheral ulcer by using a liquid fluorocarbon compound as an active component. CONSTITUTION:A liquid fluorocarbon compound having a viscosity of 300-650 cp at 25 deg.C and a molecular weight of 750-3,000 is used as an active component of the paste. When a known drug-active component is compounded to the paste, the drug action is promoted by the oxygen-supplying capability of the gel paste. It is useful for the treatment of decubital ulcus cruris, ischemic ulcer, neurogenic ulcer, etc. The liquid fluorocarbon compound is a mixture of perfluorinated compounds obtained by the direct fluorination of pitch at 0-550 deg.C. It has excellent water-resistance oil-resistance stain resistance, lubricity, oxygen affinity, etc., and extremely high chemical and biological stability.
The invention discloses a traditional Chinese medicine composition for curing gynecologic inflammation and a preparation method thereof and belongs to the technical field of traditional Chinese medicine. The traditional Chinese medicine composition is reasonably prepared, according to the principle of assistant and guide in theories of traditional Chinese medicine, by ten traditional Chinese medicines of Codonopsis pilosula, rhizoma sparganii, medicated leaven, scorched hawthorn fruit, peach kernel and the like, and emphasis is given to the holism concept. Codonopsis pilosula is capable of nourishing vitality and tonifying spleen and is a monarch drug in the prescription. Salvia miltiorrhiza and peach kernel are capable of promoting blood circulation to remove blood stasis, radix paeoniae rubra is capable of clearing heat and activating blood, rhizoma sparganii and curcuma zedoary are capable of activating blood to promote menstruation, houttuynia cordata is capable of clearing away heat and toxic materials and removing carbuncle and discharging pus, and the above six drugs are ministerial drugs. Scorched hawthorn fruit, darkmalt and medicated leaven are capable of helping digestion and harmonizing stomach and are assistant drugs. All the drugs are used together to achieve a good curative effect. The traditional Chinese medicine composition mainly aims at diseases of depletion of liver, kidney, spleen and stomach, and is effective in curing gynecologic inflammation, irregular menstruation and the like. The traditional Chinese medicine composition is a pure Chinese herba preparation, does not contain any chemical component, is safe, reliable and non-toxic in long-term use, and is capable of truly achieving the purpose of resolving the current problems and eliminating the root causes.
The purpose of this study is to learn ways to improve treatments for women with military sexual trauma (MST). The researchers want to learn whether combining evidence-based emotion regulation skills training with a trauma-focused therapy improves treatment outcomes. An evidence-based trauma treatment known as Prolonged Exposure will be used. Emotion regulation skills will also be included in treatment. Veterans with a positive or sub threshold diagnosis of PTSD who experienced a military sexual trauma (MST) will be included. Participants will complete up to twelve 90 minute sessions of PE with Dialectical Behavior Therapy (DBT) Emotion Regulation Skills Training followed by a post-treatment assessment. All aspects of the project including consent, baseline, treatment and follow-up will be completed either in person or via videoconferencing. Fifteen participants will be enrolled.