anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: The Global Burden of Disease (GBD) study is increasingly well informed with regard to headache disorders, but sub-Saharan Africa (SSA) remains one of the large regions of the world with limited data directly derived from population-based studies. The Global Campaign against Headache has conducted three studies in this region: Ethiopia in the east, Zambia in the south and Cameroon in Central SSA. Here we report a similar study in Benin, the first from West SSA.
METHODS: We used the same methods and questionnaire, applying cluster-randomized sampling in three regions of the country, randomly selecting households in each region, visiting these unannounced and randomly selecting one adult member (aged 18-65 years) of each household. The HARDSHIP structured questionnaire, translated into Central African French, was administered face-to-face by trained interviewers. Demographic enquiry was followed by diagnostic questions based on ICHD-3 criteria.
RESULTS: From 2,550 households with eligible members, we recruited 2,400 participants (participating proportion 94.1%). Headache ever was reported by almost all (95.2%), this being the lifetime prevalence. Headache in the last year was reported by 74.9%. Age-, gender- and habitation-adjusted estimates of 1-year prevalence were 72.9% for all headache, 21.2% for migraine (including definite and probable), 43.1% for TTH (also including definite and probable), 4.5% for probable medication-overuse (pMOH) and 3.1% for other headache on ≥ 15 days/month. One-day (point) prevalence of headache was 14.8% according to reported headache on the day preceding interview.
CONCLUSIONS: Overall, these findings are evidence that headache disorders are very common in Benin, a low-income country. The prevalence of pMOH, well above the estimated global mean of 1-2%, is evidence that poverty is not a bar to medication overuse. The findings are very much the same as those in a similar study in its near neighbour, Cameroon. With regard to migraine, they are reasonably in accord with two of three earlier studies in selected Beninese populations, which did not take account of probable migraine. This study adds to the hitherto limited knowledge of headache in SSA.
An autism-associated gene Shank3 encodes multiple splicing isoforms, Shank3a-f. We have recently reported that Shank3a/b-knockout mice were more susceptible to kainic acid-induced seizures than wild-type mice at 4 weeks of age. Little is known, however, about how the N-terminal and ankyrin repeat domains (NT-Ank) of Shank3a/b regulate multiple molecular signals in the developing brain. To explore the functional roles of Shank3a/b, we performed a mass spectrometry-based proteomic search for proteins interacting with GFP-tagged NT-Ank. In this study, NT-Ank was predicted to form a variety of complexes with a total of 348 proteins, in which RNA-binding (n = 102), spliceosome (n = 22), and ribosome-associated molecules (n = 9) were significantly enriched. Among them, an X-linked intellectual disability-associated protein, Nono, was identified as a NT-Ank-binding protein. Coimmunoprecipitation assays validated the interaction of Shank3 with Nono in the mouse brain. In agreement with these data, the thalamus of Shank3a/b-knockout mice aberrantly expressed splicing isoforms of autism-associated genes, Nrxn1 and Eif4G1, before and after seizures with kainic acid treatment. These data indicate that Shank3 interacts with multiple RNA-binding proteins in the postnatal brain, thereby regulating the homeostatic expression of splicing isoforms for autism-associated genes after birth.
PROBLEM TO BE SOLVED: To obtain a delayed foaming gel composition exhibiting a foam eliminating effect while keeping a delayed foaming property by adding a specific amount of an alkylglycoside into a system blended with a gelling agent and a delayed foaming agent by each specific amount. SOLUTION: This delayed foaming gel composition is obtained by blending 0.05-5wt.% alkylglycoside to a system containing 0.01-5wt.% gelling agent and 0.1-10wt.% delayed foaming agent. By applying a shearing stress to the composition in the atmosphere, a foam formed by the shearing stress can be applied directly to the hair or skin, and the foam disappears soon during a hair styling or a spreading over the skin. The composition can be applied as a cosmetic water, a hair treatment agent, a hair setting agent, a hair dyestuff, a permanent wave agent, cleaning agent, etc. As the gelling agent, a carboxyvinylpolymer, a methylcellulose, a guar gum, etc., are used. As the delayed foaming agent, propane, butane, etc., are used. As the alkylglycoside, a compound of the formula [R is a 2-20C alkyl; (n) is 1-5] (e.g.; dodecylglycoside) is preferable.
PROBLEM TO BE SOLVED: To easily produce an emulsified cosmetic having a stable emulsified state by compounding a cationic surfactant and an anionic material. SOLUTION: This cosmetic is produced by mixing an oil phase having dissolved a cationic surfactant (e.g., lauroyltrimethylammonium chloride) and an aqueous phase having dissolved an anionic material (e g., polyaspartic acid) and subsequently emulsifying the mixture by stirring, etc. The cationic surfactant is contained at the concentration of 0.05-10wt.% and the anionic material at 0.1-30wt.%. Optionally, the oil phase contains a hydrocarbon, a higher alcohol, a nonionic surfactant, their mixture, etc., and the aqueous phase contains a water-miscible organic solvent such as ethanol. One kind or more selected from anionic surfactants, anionic polymers and organic acids (e.g., pyrrolidone carboxylic acid) are used as the anionic material. The cosmetic can be applied to a hair cosmetic, a skin cosmetic, a makeup cosmetic, a bathing agent, etc.
The present invention discloses an oral formulation of hydroxycamptothecin and a preparation method thereof. Compositions of the formulation of the present invention contain hydroxycamptothecin used as active ingredients. In addition, a given amount of basic salt is added to polyethyleneglycol which is skeleton forming material, which leads medicine to have good dissolution in media. In animal pharmacodynamics tests, good effect of suppressing tumour is displayed. When the dose of a hydroxycamptothecin drop pill is 8 mg/kg and 12 mg/kg, the hydroxycamptothecin drop pill has the obvious testbed therapeutical effect for S-180 sarcoma of a mouse, and the intensity of the effect is the same as injection of hydroxycamptothecin. When the dose of a hydroxycamptothecin drop pill is 4, 8 and 12 mg/kg, the hydroxycamptothecin drop pill has the obvious testbed therapeutical effect for Lewis lung cancer of a mouse, and the effect is weaker than the intensity of the injection of hydroxycamptothecin with the same dose.
Sedentary behavior, in excess, is associated with numerous health consequences including poor physical function. Older adults with symptomatic knee pain spend the majority of their waking hours engaging in sedentary behaviors. To reduce the risk of disability, improve quality of life, and prevent deterioration in physical function, it is imperative the investigators develop ways to reduce sedentary time. Smartphone ownership among older adults is increasing and may provide a scalable opportunity to disseminate a sedentary reduction intervention. Therefore, this study aims to evaluate and compare changes in sedentary behavior and physical function between an mHealth sedentary reduction, mHealth intervention plus coaching, and delayed mHealth group. Sedentary behavior and physical function will be assessed at baseline, 1 month, 3 months, and 6 months after randomization.
More and more evidence shows that long non-coding RNA (lncRNA) plays an important role in the biological behavior of many kinds of malignant tumors, but the specific function of lncRNA Linc00657 in cervical cancer is still unknown. The purpose of this study is to explore the effect of Linc00657 on the malignant progression of cervical cancer and its potential mechanism. In two kinds of cervical cancer cell lines and normal cervical epithelial cells, qRT-PCR showed increased expression of Linc00657 in cervical cancer cells. Through MTT, clone formation test, flow cytometry, wound healing test and Transwell test, it has been found that overexpression of Linc00657 could promote the proliferation,migration and invasion of cervical cancer cells,and inhibit apoptosis. Through the StarBase database, it was found that there may be a mutual regulatory relationship between Linc00657 and Skp2, and Skp2 may be the downstream target of Linc00657. QRT-PCR detection confirmed that the expression of Skp2 was increased in cervical cancer cells with overexpression of Linc00657. TIMER2 database found that Skp2 was associated with lipid metabolic enzymes and immune cell infiltration. It was found that Linc00657 knockdown inhibited tumor growth and metastasis and inhibited the expression of Skp2 in vivo. In short, our research shows that Linc00657 has carcinogenic properties in cervical cancer, and LINC00657 promotes the occurrence of cervical cancer by up-regulating the expression of Skp2. We predict that Linc00657/mir30s/Skp2 axis plays a role in the malignant progression of cervical cancer. In addition, Skp2 may participate in cancer immune response and promote lymph node metastasis of cervical cancer through lipid reprogramming. These findings also provide promising targets for the diagnosis and treatment of cervical cancer.
Arterial puncture is a painful procedure performed to assess patients' respiratory status. Pain is a stressful situation for unconscious patients as they cannot communicate their feeling verbally. To control patients' pain and prevent the adverse effects of painkillers, nonpharmacological pain management strategies have been solicited. The aim of this study is to investigate the effect of cryoanalgesia on unconscious patients' pain during arterial puncture. We adopted a quasi-experimental one-group research design. A sample of 86 unconscious patients in a surgical intensive care unit were recruited in this study. The intervention was applying an ice pack over the puncture site for 5 minutes before the arterial puncture procedure. Pain was assessed for 2 times; before and after application of cryoanalgesia. A statistically significant difference in participants' pain scores between pre-tests and post-tests was noted. For the intubated ventilated participants, the mean pain score before and after applying cryoanalgesia was 5.26 versus 4.00 (P ≤ .05). For the non-intubated or intubated non-ventilated participants, the mean pain score was 6.66 versus 4.63 (P ≤ .05). Cryoanalgesia is a feasible and effective method incorporate during arterial puncture along with standard procedure elements to achieve maximum pain reduction for unconscious patients during arterial punctures.
UNLABELLED: Dysregulation of cholesterol homeostasis is implicated in the development and progression of hepatocellular carcinoma (HCC) that is characterized by intrahepatic and early extrahepatic metastases. A better understanding of the underlying mechanisms regulating cholesterol metabolism in HCC could help identify strategies to circumvent the aggressive phenotype. Here, we found that high expression of intracellular SPARC (secreted protein acidic and rich in cysteine) was significantly associated with elevated cholesterol levels and an enhanced invasive phenotype in HCC. SPARC potentiated cholesterol accumulation in HCC cells during tumor progression by stabilizing the ApoE protein. Mechanistically, SPARC competitively bound to ApoE, impairing its interaction with the E3 ligase tripartite motif containing 21 (TRIM21) and preventing its ubiquitylation and subsequent degradation. ApoE accumulation led to cholesterol enrichment in HCC cells, stimulating PI3K-AKT signaling and inducing epithelial-mesenchymal transition (EMT). Importantly, sorafenib-resistant HCC cells were characterized by increased expression of intracellular SPARC, elevated cholesterol levels, and enhanced invasive capacity. Inhibiting SPARC expression or reducing cholesterol levels enhanced the sensitivity of HCC cells to sorafenib treatment. Together, these findings unveil interplay between SPARC and cholesterol homeostasis. Targeting SPARC-triggered cholesterol-dependent oncogenic signaling is a potential therapeutic strategy for advanced HCC.
SIGNIFICANCE: Intracellular SPARC boosts cholesterol availability to fuel invasion and drug resistance in hepatocellular carcinoma, providing a rational approach to improve the treatment of advanced liver cancer.
The investigators propose to conduct a pilot study to test feasibility and proof-of-concept for two incentive programs to promote exercise among low-active overweight and obese adults. To address weaknesses in the literature, the programs will be (a) conducted in a community setting by the Greater Providence YMCAs and (b) financially sustainable, such that they do not require removal of the incentives after a specified period of time. In both incentive programs, participants will pay the standard monthly YMCA membership fee. In the Rebate incentive program, participants will have the opportunity to earn a small monetary incentive to exercise for each day that they attend the YMCA (verified by objective swipe-card data), with a maximum of 5 exercise sessions being incentivized per week. In the Donation incentive program, participants will have the opportunity to earn a small monetary incentive to exercise in the form of donations (using the same incentive schedule) to a registered local charity of the participant's choice. Thus, the proposed study will compare three experimental conditions: (a) Rebate incentives (n=25); (b) Donation incentives (n=25); and (c) Control (i.e., no incentives) (n=25). The Primary Aims are to test (1) feasibility of the two incentive programs, (2) feasibility of the research methods to evaluate the preliminary efficacy of the two incentive programs, and (3) proof-of-concept for the two incentive programs (relative to control), through comparison of average number of sessions/week with incentives over one year. Secondary outcomes will be self-reported minutes per week of exercise over one year. The proposed research will provide a preliminary investigation into two community-based, financially sustainable incentive programs to promote exercise for adults who are at increased risk for cancer. Positive findings from such a trial would provide a fast-track for a community-based ready-to-implement exercise promotion intervention. Additionally, such findings would have significant implications for the use of financially sustainable incentive programs for exercise through other community organizations (e.g., privately-owned health clubs), healthcare organizations, or employers (e.g., employer fitness facilities), as well as providing a model for incentive programs for other health-related behaviors (e.g., smoking cessation, weight loss).
This invention is based on an efficient treatment of diabetic neurotherapy. The drug combination is made up three ingredients. These are taurine, folic acid and methylcobalamin. These are working as a synergistic compound for the treatment of diabetic neurotherapy the concentration of these compounds are Methylcobalamin is 1500 microgram per tablet, taurine is 500 mg per tablet and folic acid is 5 mg per tablet. In this combination taurine is used for anxiolytic effect and may act as a modulator or anti- anxiety agent in the central nervous system. Folic acid is used for the mechanism of blood glucose control. It is essential because glucose causes high levels of oxidative stress throughout the body. In antioxidant therapy folic acid is very important antioxidant to help prevent neuropathy and Methylcobalamin is used in the treatment of diabetic neuropathy, it is a form of vitamin B12. Methylcobalamin are necessary to correct neurological defects. This combination can provide relief in infections on the feet and legs, in multiple fractures of the knee, ankle or foot, a Charcot joint as well as loss of motor function resulting in dorsiflexion, contractures of the toes, loss of the interosseous muscle function and contraction of the digits, so called hammer toes, loss of the musculature making the hand appear gaunt and skeletal and the loss of muscular function.
The purpose of this study was to investigate the effects of a novel dietary supplement, including melatonin and magnesium, delivered via coffee pods on sleep quality, resting metabolic rate (RMR), and body composition in individuals with poor sleep quality disturbances. Using a double-blinded, randomized, crossover trial, we recruited 35 participants to a 4-week intervention with both supplements (1.9 mg melatonin + 200 mg elemental magnesium before sleep) and placebo conditions, considering a 7d washout period between treatments. The Pittsburgh Sleep Quality Index (PSQI) questionnaire was applied, RMR (kcal) was measured using indirect calorimetry (canopy ventilated open-circuit system) and body composition was assessed using dual-energy X-ray absorptiometry. Decreases in PSQI and anger - hostility scores, as well as in energy intake and fat mass, were observed (p < 0.05) for both conditions, from baseline to the end of each 4-week intervention. Differences between conditions were also observed for these parameters along with energy spent in activity, number of sedentary breaks, sleep efficiency, latency time, time in bed, total sleep time, awakening time, and movement index (p < 0.05) favouring the supplement condition. However, the final PSQI questionnaire scores still indicated poor sleep quality on average (PSQI > 5), in both conditions, with no changes regarding RMR. A melatonin-magnesium supplement, in a coffee pod format, showed improvements in sleep quality in otherwise healthy individuals with sleep disturbances, however PSQI questionnaire scores still indicated poor quality on average (PSQI > 5).
Disclosed is a pharmaceutical composition for preventing or treating hearing loss, comprising  Cuscuta japonica  Choisy extract, or the extract of  Rehmannia glutinosa  Libschitz var.  purpurea  MAKINO and  Cuscuta japonica  Choisy. In addition, the present invention provides a food composition for preventing or ameliorating hearing loss, comprising  Cuscuta japonica  Choisy extract, or the extract of  Rehmannia glutinosa  Libschitz var.  purpurea  MAKINO and  Cuscuta japonica  Choisy. The composition inhibits hearing loss, in particular, acoustic trauma, temporary or permanent hearing loss by effectively inhibiting the threshold shift induced by noise and the likes, and thusit is effective in preventing or treating hearing loss. In addition, it can be administered orally, thereby drug compliance of patients can be enhanced.
The transition to motherhood is one of the life stages that brings about stress and change. Primiparous mothers, who will experience motherhood for the first time due to anxiety about the unknown, may experience more stress and their communication with their babies may deteriorate. In this process, the mother's seeing, touching and interacting with her baby positively affects her perception of her baby. The easiest and most natural way to do this is baby massage. Touching and massaging the baby maintains the baby's body contact, which strengthens the baby's sense of trust and supports the mother's development of attachment behavior. It also reduces mothers' levels of stress hormones such as cortisol and relieves depressive symptoms.
This will consist of patients who are ASA I or II status, 3-8 years old, males and females, and present with restorable primary molars with reversible pulpitis and free of clinical radiographic signs of pulp pathology. From these study participants, they will be randomly assigned to this or other group. Patients in this group will receive a pulpotomy. Then a GENTLEray 980 Soft Tissue diode laser (Power: 3.0W, Mode: PW, Fiber: 300µm, Ton: 100ms, Toff: 100ms, Timer: cont) will be used to vaporize the residual pulp tissue and complete hemostasis. IRM (Zinc Oxide Eugenol) cement is then placed to seal the pulp chamber. A stainless steel crown cemented with Ketac Cement for the full coverage final restoration completes the pulpotomy procedure.
The invention provides compositions and methods to monitor delivery of nucleic acids (e.g., such as genes) to a target cell. The compositions comprise a nucleic acid delivery vehicle and a contrast agent. Preferably, the contrast agent is suitable for use in magnetic resonance imaging (MRI). The compositions can be used to monitor the efficacy and selectivity of gene delivery. The invention also provides a medical access device for delivering compositions according to the invention to a target tissue. Preferably, the medical access device comprises a perfusion-porous nucleic acid delivery balloon catheter which can be used in an interventional vascular procedure.
During pregnancy, chronic hypertension (CHTN) is the most common major medical disorder encountered, occurring in 2-6%. The substantial negative effect of CHTN on pregnancy includes a consistent 3- to 5-fold increase in superimposed preeclampsia and adverse perinatal outcomes (fetal or neonatal death, preterm birth -PTB, poor fetal growth and placental abruption) and possibly a 5- to10-fold increase in maternal cardiovascular and other complications (death, cerebrovascular accident, pulmonary edema and acute renal failure). Mild CHTN (BP \<160/110) contributes to a large proportion of these adverse outcomes. While antihypertensive treatment of CHTN is standard for the general population, it is uncertain whether treatment during pregnancy reduces maternal or fetal complications, and there are concerns that decreased arterial pressure may reduce fetal blood flow and cause poor fetal growth or small-for-gestational-age (SGA) infants. Some authorities, including the American College of Obstetricians and Gynecologists (ACOG) and American Society of Hypertension (ASH) recommend withholding antihypertensive therapy for mild CHTN, particularly if BP is \<160/105-110 mmHg. The recommendation to withhold antihypertensive treatment in pregnancy conflicts with the broader public health goal to reduce BP in those with CHTN and there is no evidence that discontinuing therapy during the brief period of pregnancy affects maternal outcomes (other than reducing the severe hypertension). For over a decade, authorities have consistently called for well-designed and powered trials to delineate the benefits and risks of pharmacologic therapy for CHTN during pregnancy.

Therefore, our multicenter consortium proposes the Chronic Hypertension and Pregnancy (CHAP) Project, a large pragmatic randomized trial with a primary aim to evaluate the benefits and harms of pharmacologic treatment of mild CHTN in pregnancy.
The invention relates to health Chinese coffee for expelling parasites, which comprises the following components in parts by weight: 2-5 parts of traditional Chinese medicine extract powder, 3-7 parts of cocoa powder and 2-5 parts of isomalto-oligosaccharide. The traditional Chinese medicine extract powder is prepared from the following components: 1-2 parts of semen cassiae, 2-5 parts of rhizoma polygonati, 2-5 parts of Chinese wolfberry fruits, 1-3 parts of dandelion and 1-4 parts of honeysuckle. The Chinese coffee provided by the invention can effectively dispel pathogenic microorganisms so as to achieve the purposes of enhancing body immunity, preventing sub-health and enhancing health. Semen cassiae, rhizoma polygonati, Chinese wolfberry fruits, dandelion and honeysuckle in the formula are all traditional Chinese medicines capable of being used as food, are food and medicines with the effect of treating diseases, and actually are top-grade traditional Chinese medicines. Isomalto-oligosaccharide is a bifidobacterium multiplication factor containing panose, isomaltose, isomaltotriose and the like as main ingredients, cannot be utilized by harmful bacteria, and can be directly fed to bifidobacteria in a large intestine to promote the activation and reproduction of the bifidobacteria. The coffee adopting the formula not only can be used for treating diseases, but also can be drunk for a long time to enhance health and prevent sub-health.