anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Disclosed herein are methods for generating a video surgical report using a machine learning pipeline. The machine learning pipeline may include one or more machine learning models, each of which may support a particular aspect of a video surgical report generation process. For example, one or more images of a surgical procedure may be obtained. Using one or more machine learning models, a set of images from the one or more images may be selected based on the surgical procedure. A video surgical report may be generated for the surgical procedure, which may include at least some of the set of images. The machine learning pipeline can offload work typically performed by a user (e.g., surgeon, medical staff, etc.) to create the video surgical report, thereby saving significant time and/or resources.
PCT No. PCT/CA97/00319 Sec. 371 Date Jan. 13, 1999 Sec. 102(e) Date Jan. 13, 1999 PCT Filed May 9, 1997 PCT Pub. No. WO97/42962 PCT Pub. Date Nov. 20, 1997This invention relates to formulations comprising film-forming components capable of forming per se a physical barrier to pathogens. Thermoreversible gels such as poloxamers are particularly preferred for that use. The film-forming formulations may further comprise microbicides, spermicides or any other drug, which choice is guided by the pathogen, organism or the disease to be inactivated or treated. The formulations are therefore efficient as a physical, and optionally, as a chemical or pharmacological barrier as well as usable as a sustained drug-release system at the locus of administration. A part of the drug may also be entrapped in liposomes or other drug carriers. These formulations are intended for use in the prevention of sexually transmitted diseases, as well as in the treatment of infections, cancer, inflammation or any disease or state which requires a pharmacological treatment. Formulations are applicable to mucosae, skin and eye, for example.
PURPOSE:To efficiently obtain the titled compound having inhibitory action on cell division in high yield, by extracting tissues of a leguminous plant with a specific solvent, removing the solvent fro the aqueous solution layer, adjusting the pH of the aqueous solution layer, extracting the adjusted layer with a specific solvent to separate and purify the titled compound. CONSTITUTION:Tissues of a leguminous plant, e.g. white clover (Trifolium repens L.) are extracted with an aqueous solution of a water-soluble solvent having <=95 deg.C boiling point, e.g. ethanol or acetone, which is then removed from the treated solution by evaporation or distillation under ordinary pressure or reduced pressure. The resultant residual aqueous solution layer is adjusted to 6.5-8.5pH by adding sodium bicarbonate thereto and the solvent extraction is carried out by using a polar solvent slightly soluble in water, e.g. ethyl acetate or dichloromethane. The extracted solution is then subjected to gel filtration with preferably an oleophilic gel column, e.g. sephadex column LH-20, separated and purified to separate the aimed compound. EFFECT:The aimed compound can be readily separated and purified in a large amount rapidly in a short time and the method is industrially advantageous.
AIM: To determine the relationship between preoperative nutritional status assessed using anthropometric measures and postoperative complications in pediatric surgical patients.
METHODOLOGY: This prospective observational cohort study included 650 patients from 6 months to 18 years undergoing elective surgery at our institution. Elective surgery included procedures such as herniotomy, orchidopexy, urethroplasty, cystoscopy, PUV fulguration, pyeloplasty, ureteric reimplantation, stoma formation/closure, anorectoplasty, pull-through, choledochal cyst excision and repair, VP shunt insertion, lipomyelomeningocele repair, diastematomyelia excision and repair, and cyst excision. Nutritional status was standardized using Z scores for weight, length, and BMI. Patients were monitored for a month following surgery to detect any complications, and they were classified into five grades using the Clavien-Dindo classification. The duration of hospital stays and readmission within 30 days following discharge were secondary outcomes.
RESULTS: There were 627 patients of both sexes involved in the study: 350 patients aged 6 months to 5 years (Group A), while 277 were aged between 5 and 18 years (Group B). Wasting status was 47.71% in Group A and 41.52% in Group B. In Group A, 40% of patients were stunted, while 83.75% were in Group B. Group A had 57.14% underweight patients. The complication rate was 39.14% in Group A and 38.99% in Group B. The incidence of postoperative complications was not significantly different in malnourished patients. The patients with prolonged duration of surgery (> 2 h) developed more complications in both groups (Group A-67.2%, Group B-82.6%; p < 0.0001). In addition, the patients who experienced complications had lengthier hospital stays (p < 0.001 in both groups) and increased readmission rates (p = 0.016 in Group A and p = 0.008 in Group B).
CONCLUSION: In our study, half of the patients in Group A and nearly two-third in Group B were malnourished. The preoperative poor nutritional status based on anthropometric parameters is not associated with increased postoperative complications. Randomized control trials linking preoperative malnutrition based on anthropometric measures and clinical outcomes in pediatric surgery patients are necessary to provide more robust information on this subject.
1,152,934. Foot and mouth disease vaccine. INSTITUT FRANCAIS DE LA FIBVRE APHTEUSE. 29 Nov., 1967 [22 June, 1967], No. 54403/67. Heading A5B. A vaccine against foot and mouth disease is produced by cultivating the virus of foot and mouth disease on glossal epithelia of bovines in a first culture medium, separating the first culture medium, adding fresh culture medium to the bovine glossal epithelia, continning the cultivation in the second culture medium, separating the second culture medium, repeating, if desired, the addition of fresh culture medium and cultivation of the virus therein one or more times, and finally inactivating the cultivated virus in the separated culture medium to produce the Vaccine. The first cultivation may take place for 15 to 20 hours and the second for 3 to 12 hours; The vaccine may comprise the separated mixed culture media from the cultivations or a liquid obtained by grinding the separated bovine glossal epithelia and extracting the ground bovine glossal epithelia with a buffer liquid added to the separated culture medium of one or more cultivations. Inactivation may be effected by adsorption of the virus on aluminium hydroxide or by the combined action of formaldehyde and heat.
Autoimmune neuropathies are a heterogeneous group of immune-mediated disorders of the peripheral nerves. Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are the archetypal acute and chronic forms. Over the past few decades, pathogenic antibodies targeting antigens of the peripheral nervous system and driving peripheral nerve damage in selected patients have been described. Moreover, the detection of these antibodies has diagnostic and therapeutic implications that have prompted a modification of the GBS and CIDP diagnostic algorithms. GBS diagnosis is based in clinical criteria, and systematic testing of anti-ganglioside antibodies is not required. Nonetheless, a positive anti-ganglioside antibody test may support the clinical suspicion when diagnosis of GBS (GM1 IgG), Miller Fisher (GQ1b IgG), or acute sensory-ataxic (GD1b IgG) syndromes is uncertain. Anti-myelin-associated glycoprotein (MAG) IgM and anti-disialosyl IgM antibodies are key in the diagnosis of anti-MAG neuropathy and chronic ataxic neuropathy, ophthalmoplegia, M-protein, cold agglutinins, and disialosyl antibodies spectrum neuropathies, respectively, and help differentiating these conditions from CIDP. Recently, the field has been boosted by the discovery of pathogenic antibodies targeting proteins of the node of Ranvier contactin-1, contactin-associated protein 1, and nodal and paranodal isoforms of neurofascin (NF140, NF186, or NF155). These antibodies define subgroups of patients with specific clinical (most importantly poor or partial response to conventional therapies and excellent response to anti-CD20 therapy) and pathologic (node of Ranvier disruption in the absence of inflammation) features that led to the definition of the "autoimmune nodopathy" diagnostic category and to the incorporation of nodal/paranodal antibodies to clinical routine testing. The purpose of this review was to provide a practical vision for the general neurologist of the use of antibodies in the clinical assessment of autoimmune neuropathies.
Physiotherapy students of the Rovira i Virgili University aged between 18 and 35 years enrolled during the academic year 2022-2023. All participants were allowed three practice trials for each test. Consistent feedback was provided throughout to ensure proper technique. Electrodes were placed to assess muscle activity according to SENIAM recommendations in gluteus medius, gluteus maximus, tibialis anterior and peroneus longus. After electrode placement, a maximal isometric strength test (MVIC) was performed for each muscle to normalize the electromyographic data. During this MVIC test, the maximum isometric force was measured using the Chronojump Boscosystem force gauge. Following this, ankle stability evaluation tests were performed. The Single Leg Stance Test, the Hurdle Step test and finally the Single leg vertical jump will be performed.
A system and method for renewing prescriptions is provided. Visitors to a web site, who may or may not register, are given the opportunity to request renewals of drug prescriptions on the web site. Visitors are prompted to enter information relevant to the renewal. The web site in one alternative maintains a database of visitors medical and/or contact information and issues a membership ID or Plan ID. In an alternative the web site may offer an opt-in buyer's club for obtaining discounts or information about prescriptions. The web site, in one alternative, maintains a database of information about doctors who are registered with the web site. The visitor may then select a doctor from a list and use the site to request a prescription renewal from that doctor. The web site uses information entered by the visitor, or information previously provided by the visitor accessed from the web site's database, to format a fax or email to the doctor requesting a renewal of the visitors prescription. The fax or email may contain the name, address, telephone number and prescription plan ID of the patient, the name, address, telephone number and DEA number of the doctor, the drug to be refilled, the quantity and dosage of the refill. The fax or email will contain the fax number and phone number or email address of the pharmacy (or Pharmaceutical Benefits Manager, “PBM”, for example Express Scripts.) Finally, the fax or email will contain a signature line or sufficient facility for electronic signature to be signed by the doctor. Upon completion of the request by the visitor, the system forwards the request directly to the doctor via fax or electronically. The doctor may then sign the request and fax or electronically transmit the request to a pharmacy or PBM.
All adults enlisted for liver transplantation at Copenhagen University Hospital - Rigshospitalet (N = around 60 per year) will be invited to participate regardless of indication for liver transplantation. These participants are expected to undergo a liver transplantation and will continue in the study after the procedure.
New process converts active substance with an NH2 group into polymeric form, intended for prolonged release of the active substance by enzymatic cleavage. A substd. amide or ester of acrylic or methacrylic acid having a chain of is not 3 atoms in the side-chain terminating in the C-atom of the carboxyl group is condensed with the alpha-amino group of an L-amino acid. The active cpd. is then bound via its NH2 group to the carboxyl group of the amino acid. The resulting monomer is copolymerized with a hydrophilic monomer based on N-alkyl-(meth)acrylamide, or N, N-dialkylacrylamide ('alkyl' being 1-6C). The hydrophilic monomer may contain 1-3 OH groups or glycol (meth)acrylate ('glycol' being ethylene, propylene, butylene, diethylene or triethylene glycol, or homologous 2-6C polyglycols). The copolymerization can be carried out in the presence of smaller amts. of further monomers, which can act as crosslinking agents. The polymers permit regulation of the physical and biological behaviour of the active substance by variation of the character and molecular weight of the polymeric carrier. Rate of enzymatic cleavage can also be regulated by the length of the side-chain. The active substance is protected against premature excretion and against inactivation (e.g. histamine can be protected against the action of histaminase). Examples of L amino acids which can be used are phenylalanine, tyrosine, alanine, citrulline and ornithine. In an example, a copolymer contg. 97.6 mol. % N-(2-hydroxypropyl)-methacrylamide and 2.4 mol. % N-methacryloylglycylphenylalanyl nitroanilide is produced by direct copolymerization. The copolymer is used as a substrate for enzymatic cleavage by chymotrypsin.
Pain and inflammation are predictable sequelae following tissue injury, such as surgery. Conventional treatment for intraoperative and postoperative control of pain includes local anesthetic administered preoperatively and analgesics administered postoperatively. Disadvantages of these approaches include pain during the interval when the effect of local anesthesia dissipates and the postoperatively administered analgesic takes effect and adverse effects of opioid-containing analgesics in ambulatory patients. Research over the past two decades has demonstrated that administering nonsteroidal anti-inflammatory drugs (NSAIDs) preoperatively significantly reduces the intensity and the duration of postoperative pain up to eight hours (Dionne et al., 1978 and Jackson et al., 1989). Parallel clinical investigations suggest that the pre-emptive treatment with a long-acting local anesthetic or an NMDA-antagonist reduces pain at 24 to 72 hours post-surgery (Gordon et al., 1997; Yamamoto et al., 1993; Gordon et al., 1999). This proposed clinical trial will use the oral surgery model to assess the therapeutic efficacy of pre-emptive and preventive treatment with a potent selective COX-2 inhibitor, rofecoxib (Vioxx® (Registered Trademark)), given prior to and following third molar extractions to reduce postoperative pain at 24 and 48 hours post-surgery.

This study is a double-blind, randomized control trial with parallel groups using placebo, ibuprofen, or rofecoxib. Rofecoxib 50 mg will be administered PO 90 minutes before surgery in the Clinical Center at NIH and another 50 mg will be self-administered 24 hours later by the subjects at their homes. This regimen is predicted to suppress the onset and intensity of post-operative dental pain to a greater extent than placebo or a non-selective COX-1/COX-2 inhibitor (ibuprofen). The analgesic effect of the drugs will be estimated by hourly observations over the first four hours after surgery using two different measures of pain intensity, the category scale and a visual analog scale (VAS). It is hypothesized that the pre-emptive administration of a selective COX-2 inhibitor, rofecoxib will inhibit the development of central and peripheral sensitization following tissue injury which manifests as hyperalgesia at later time points.
The neural mechanisms underlying language recovery after a stroke remain controversial. This review aimed to summarize the plasticity and reorganization mechanisms of the language network through neuroimaging studies. Initially, we discussed the involvement of right language homologues, perilesional tissue, and domain-general networks. Subsequently, we summarized the white matter functional mapping and remodeling mechanisms associated with language subskills. Finally, we explored how non-invasive brain stimulation (NIBS) promoted language recovery by inducing neural network plasticity. It was observed that the recruitment of right hemisphere language area homologues played a pivotal role in the early stages of frontal post-stroke aphasia (PSA), particularly in patients with larger lesions. Perilesional plasticity correlated with improved speech performance and prognosis. The domain-general networks could respond to increased "effort" in a task-dependent manner from the top-down when the downstream language network was impaired. Fluency, repetition, comprehension, naming, and reading skills exhibited overlapping and unique dual-pathway functional mapping models. In the acute phase, the structural remodeling of white matter tracts became challenging, with recovery predominantly dependent on cortical activation. Similar to the pattern of cortical activation, during the subacute and chronic phases, improvements in language functions depended, respectively, on the remodeling of right white matter tracts and the restoration of left-lateralized language structural network patterns. Moreover, the midline superior frontal gyrus/dorsal anterior cingulate cortex emerged as a promising target for NIBS. These findings offered theoretical insights for the early personalized treatment of aphasia after stroke.
Eligible subjects will receive an implanted device (IRS-8 or IST-16) and surgically implanted electrodes to excite muscles that move paralyzed muscles. These electrodes are connected to the implanted stimulator that delivers electrical pulses to the nerves. These pulses cause the muscles to contract to perform functional movements or to exercise.
Subarachnoid hemorrhage (SAH) is a severe neurological event lacking of effective therapy. Early brain injury (EBI) and delayed neurological dysfunction are important cause in the poor prognosis of patients with SAH. Nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 (NLRP3) inflammasome activation has been implicated in many inflammatory lesion pathogeneses including SAH. Dl-3-n-butylphthalide (NBP) has been reported to possess substantial anti-inflammatory properties, which is beneficial for various neurodegenerative diseases. However, the effect and molecular mechanisms of NBP on SAH have not been clearly identified. We designed this study to investigate the effect of NBP against EBI and delayed neurological dysfunction after SAH and to reveal the possible underlying mechanism. The adult mice were subjected to endovascular perforation SAH model or sham operation. Mice were randomized to sham group, SAH group, or SAH+NBP group. The EBI (short-term study) was studied at 48 h post-SAH and delayed neurological dysfunction (long-term study) at 21 days post-SAH. The results suggested that NBP evidently alleviated the EBI in mice at 48 h post-SAH, as shown by elevating neurological score, reducing brain edema, blood-brain barrier disruption, neuronal loss, and astrocyte aggregation, as well as ameliorating cerebral vasospasm. Moreover, NBP was able to improve long-term neurobehavioral functions and decrease neuronal apoptosis at 21 days after SAH. Significantly, NBP treatment also inhibited the expressions of NLRP3, ASC, caspase-1, cleaved-caspase-1, IL-1β, IL-18, GSDMD and GSDMD-N in both EBI and delayed neurological dysfunction induced by SAH. Our findings suggested that NBP treatment exerts a profound neuroprotective effect against early brain injury and delayed neurological dysfunction induced by SAH, at least partially through regulating NLRP3 inflammasome signaling pathway and its related inflammation and pyroptosis.
284,668. Ehrenreich, A. Feb. 3, 1927, [Convention date]. Void [Published under Sect. 91 of the Acts]. Degumming silk.-Products of the nature of enzymes are obtained from the glands of the plagiostomi such as the sharks by removing grease from the gland, extracting the active matter, and drying it to produce a dry pulversible substance. The products obtained are suitable for use in tanning, in the un-gumming of silk by eliminating grit and sericin, and for the preparation of medicines. The glands treated are in particular those under the esophagus, the first intestinal gland, the genital glands of the male and the ovaries of the female fish, that of the cerebellum and those above the organs of evacuation. The grease may be removed by an organic solvent such as acetone and the residue dried in vacuo, or after removal of the grease the residue may be extracted with water and the extract precipitated with tannin, or the aqueous extract may be absorbed in infusorial earth or sawdust for drying purposes. In a further process the glands after removal of grease are extracted with chloroform, the extract precipitated by ether and the precipitate dried in vacuo. Albumen present in the aqueous extract may be precipitated by uranyl acetate. In a further method of extraction acidified absolute alcohol is employed, the resulting extract being precipitated by an alkaline substance and washed with a mixture of alcohol and ether the process being carried out in vacuo or without admission of air.
BACKGROUND: Guidelines recommend treatment package time < 85 days and time from surgery to radiation initiation < 6 weeks in head and neck cancer patients. However, HPV positive primaries treated with TORS and adjuvant radiotherapy traditionally demonstrate favorable outcomes.
METHODS: Single center retrospective chart review of patients diagnosed with HPV positive treatment naïve primary squamous cell carcinoma treated with TORS and postoperative radiation therapy with or without Chemotherapy from 2012 to 2022 with data collection from December 2022-April 2023. Kaplan-Meier survival analysis with log-rank testing assessed the impact of time intervalsbetween diagnosis, TORS, radiation initiation and radiation completion on recurrence free and disease specific survival. Univariate Cox proportional hazards regression analysis was performed to identify factors associated with recurrence free and disease specific survival. Subgroup analysis was done with high risk (positive lymph nodes > 5, >1mm extracapsular extension, positive margins) patients who underwent concurrent Chemotherapy.
RESULTS: Of 255 patients (225 males [89 %], average age 58 years, 163 [64 %] high-risk, median follow-up 4.3 years), 22 (8.6 %) had recurrence and 14 died due after disease recurrence.Only radiation length of 5-7 weeks prolonged survival in the entire population. In the high-risk cohort, time from TORS to radiation initiation < 6 weeks improvedrecurrence free survival, while total package time < 14 weeks wasassociated with greater recurrence free and disease specific survival.
EGFR amplification in gliomas is commonly defined by an EGFR/CEP7 ratio of ≥2. In testing performed at a major reference laboratory, a small subset of patients had ≥5 copies of both EGFR and CEP7 yet were not amplified by the EGFR/CEP7 ratio and were designated high polysomy cases. To determine whether these tumors are more closely related to traditionally defined EGFR-amplified or nonamplified gliomas, a retrospective search identified 22 out of 1143 (1.9%) gliomas with an average of ≥5 copies/cell of EGFR and CEP7 with an EGFR/CEP7 ratio of <2 displaying high polysomy. Of these cases, 4 had insufficient clinicopathologic data to include in additional analysis, 15 were glioblastomas, 2 were IDH-mutant astrocytomas, and 1 was a high-grade glial neoplasm, NOS. Next-generation sequencing available on 3 cases demonstrated one with a TERT promoter mutation, TP53 mutations in all cases, and no EGFR mutations or amplifications, which most closely matched the nonamplified cases. The median overall survival times were 42.86, 66.07, and 41.14 weeks for amplified, highly polysomic, and nonamplified, respectively, and were not significantly different (p =  0.3410). High chromosome 7 polysomic gliomas are rare but our data suggest that they may be biologically similar to nonamplified gliomas.