anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Carcinogenesis: In 2-year carcinogenicity studies conducted in rats and mice using a powder formulation administered through inhalation, zanamivir induced no statistically significant increases in tumors over controls. The maximum daily exposures in rats and mice were approximately 23 to 25 and 20 to 22 times, respectively, greater than those in humans at the proposed clinical dose based on AUC comparisons.

Mutagenesis: Zanamivir was not mutagenic in in vitro and in vivo genotoxicity assays which included bacterial mutation assays in S. typhimurium and E. coli, mammalian mutation assays in mouse lymphoma, chromosomal aberration assays in human peripheral blood lymphocytes, and the in vivo mouse bone marrow micronucleus assay.

Impairment of Fertility: The effects of zanamivir on fertility and general reproductive performance were investigated in male (dosed for 10 weeks prior to mating, and throughout mating, gestation/lactation, and shortly after weaning) and female rats (dosed for 3 weeks prior to mating through Day 19 of pregnancy, or Day 21 post partum) at IV doses 1, 9, and 90 mg/kg/day. Zanamivir did not impair mating or fertility of male or female rats, and did not affect the sperm of treated male rats. The reproductive performance of the F1 generation born to female rats given zanamivir was not affected. Based on a subchronic study in rats at a 90 mg/kg/day IV dose, AUC values ranged between 142 and 199 mcg•hr/mL (>300 times the human exposure at the proposed clinical dose).
Dystonia is thought to arise from abnormalities in the motor loop of the basal ganglia; however, there is an ongoing debate regarding cerebellar involvement. We adopted an established cerebellar dystonia mouse model by injecting ouabain to examine the contribution of the cerebellum. Initially, we examined whether the entopeduncular nucleus (EPN), substantia nigra pars reticulata (SNr), globus pallidus externus (GPe) and striatal neurons were activated in the model. Next, we examined whether administration of a dopamine D1 receptor agonist and dopamine D2 receptor antagonist or selective ablation of striatal parvalbumin (PV, encoded by Pvalb)-expressing interneurons could modulate the involuntary movements of the mice. The cerebellar dystonia mice had a higher number of cells positive for c-fos (encoded by Fos) in the EPN, SNr and GPe, as well as a higher positive ratio of c-fos in striatal PV interneurons, than those in control mice. Furthermore, systemic administration of combined D1 receptor agonist and D2 receptor antagonist and selective ablation of striatal PV interneurons relieved the involuntary movements of the mice. Abnormalities in the motor loop of the basal ganglia could be crucially involved in cerebellar dystonia, and modulating PV interneurons might provide a novel treatment strategy.
All children in this study were sensitized to wheat. Each patient was clinically evaluated, with focus on wheat allergy by both a detailed medical examination and collection of medical history. Blood sample was taken for baseline determination of ImmunoglobulinE antibodies to wheat and to omega-5-gliadin. The oral wheat challenge were performed in all study subjects to identify a case of wheat outgrowing. The primary outcome was the development of oral tolerance to wheat. Oral wheat challenge were generally performed at least every 1 years if the child did not have an interval history of symptoms with unintentional exposure.
In a monotherapy study raltegravir (400 mg twice daily) demonstrated rapid antiviral activity with mean viral load reduction of 1.66 log10 copies/mL by Day 10.

In the randomized, double-blind, placebo-controlled, dose-ranging trial, Protocol 005, and Protocols 018 and 019, antiviral responses were similar among subjects regardless of dose.

Effects on Electrocardiogram 

In a randomized, placebo-controlled, crossover study, 31 healthy subjects were administered a single oral supratherapeutic dose of raltegravir 1600 mg and placebo. Peak raltegravir plasma concentrations were approximately 4-fold higher than the peak concentrations following a 400 mg dose. ISENTRESS did not appear to prolong the QTc interval for 12 hours postdose. After baseline and placebo adjustment, the maximum mean QTc change was -0.4 msec (1-sided 95% upper Cl: 3.1 msec).
The invention relates to a piece of water lily flower interesting handmade soap for children and manufacturing technology of the same. The handmade soap comprises effective components of natural plant oil such as water lily flower oil, tea tree oil, olive oil, coconut oil, and palm oil, and is carefully prepared by a series of processes. The handmade soap containing a low content of an alkaline component and containing a natural plant component of pigment and fragrance can nourish skin, can keep skin in normal physiological environment, and is safe and stable. The handmade soap can be manufactured by children, can be made into soaps with different kinds and colors, and has a natural and quietly elegant smell. The formula of the handmade soap can be selected according to the individual skin. The handmade soap has a full and mellow surface, is not easy to shrink and crack after storage, can be used while being manufactured, enables less moisture to be loss, and can keep a soap effect. Forced hand washing is changed into conscientious hand washing for children by using the handmade soap while children playing happily. The multi-function water lily flower interesting handmade soap for children has anti bacteria function, is suitable for children and people who suffer from skin allergy, provides fine, impact and stable foam while the soap is used, and makes the user's body feel fresh and cool.
Acamprosate has been shown to reduce drinking days in alcohol dependent patients and promote abstinence, with few reported side effects. A limitation of these studies, however, has been their lack of generalizability due to restrictive inclusion and exclusion criteria. Furthermore, most of the previous studies of acamprosate have been conducted in Europe, in a different treatment setting from the typical American Family Medicine center, where alcohol dependent patients are most likely to be first identified in the U.S.

The present study is designed to determine the efficacy of acamprosatefor alcohol dependence in a Family Medicine setting using minimal psychotherapeutic interventions-as would also likely occur in a primary care setting. The study will be a 12-week, double-blind, placebo-controlled, randomized trial comparing 666 mg acamprosate t.i.d. to placebo in patients at the UNC Family Medicine Center with alcohol dependence. Subjects will be seen by Family Medicine physicians and receive brief motivational interventions. Primary efficacy will be determined by measuring % days abstinent and secondary outcomes include rates of complete abstinence, % heavy drinking days, CGI and GGT in the acamprosate group compared to the placebo group.
A recombinant viral construct for expressing an exogenous polypeptide in a cell and uses thereof are provided. The recombinant viral constructs are derived from Japanese encephalitis virus (JEV). The recombinant viral constructs encodes a fusion protein, which includes an exogenous (i.e., non-JEV) polypeptide and a JEV non-structural protein 1 (JEV NS1) or a segment thereof. Particularly, the exogenous polypeptide is inserted into the carboxyl-terminus of the JEV NS1, and the production of the recombinant fusion protein does not affect viral replication. Upon infection a cell with such recombinant viral constructs, JEV particles comprising limited multiplicative virions (LMV) may be produced. Each LMV comprises the as-described JEV replicon. The JEV particles are useful in eliciting an immune response to the exogenous polypeptide in a host and thereby confer the host with protective immunization against the exogenous polypeptide.
BACKGROUND: Acute inflammation of the appendix or acute appendicitis is one of the most prevalent surgical emergencies seen in day-to-day practice. The delay in the diagnosis and the treatment of the condition can lead to complications and even death. Various scores have been developed over the time for aiding the diagnosis of Acute Appendicitis.
METHODS: A hospital based cross-sectional study was conducted in Bharatpur hospital of Chitwan district of Nepal from December 30, 2020 to December 29, 2022 .This study identified and enrolled acute appendicitis patients that were treated in a tertiary hospital's emergency department of Bharatpur. The data were obtained and used to calculate modified Alvarado, and Lintula scores. All the patients were categorized into two groups according to their histopathological results, i.e., positive appendectomy and negative appendectomy. The sensitivity and specificity of different scoring systems in diagnosing Acute appendicitis was investigated.
RESULTS: Sensitivity and specificity of Modified Alvarado score were 89.2% and 80.0% respectively. Diagnostic accuracy of Modified Alvarado Score was 88.57%. Positive productive value and Negative productive values of this scoring tool were 98.3% and 36.3% respectively whereas, diagnostic accuracy of Lintula score was 75.0%.
CONCLUSIONS: It can be inferred from the study that Modified Alvarado Score is a good screening tool for diagnosing need of appendectomy.
ETHNOPHARMACOLOGICAL RELEVANCE: Murraya koenigii (MK), a member of the Rutaceae family and widely known as the curry-leaf tree, is indigenous to India, Sri Lanka, and other south Asian nations. It is a renowned medicinal herb because of the wide range of bioactive components found in its leaves, such as girinimbine, koenimbine, mahanimbine and mahanine among others. All these bioactive components make this plant beneficial for treating a variety of ailments and diseases. Biological and pharmacological activities of MK include anti-oxidant, anti-microbial, anti-ulcer, anti-helminthic, anti-malarial, anti-trichomonal, hepatoprotective, anti-diabetic, etc. AIM OF THE STUDY: The present study aimed to evaluate the possible protective effect of hydroethanolic Murraya koenigii leaves extract (HEMKLE) against 7,12-Dimethylbenz[a]anthracene (DMBA)-induced breast cancer in rats, which further paves the way for future breast cancer treatment.
MATERIALS AND METHODS: For the preparation of hydroethanolic Murraya koenigii leaves extract (HEMKLE), Murraya koenigii (MK) leaves were taken from the botanical garden of the Panjab University campus, Chandigarh, and authenticated from the Department of Botany, Panjab University (accession number 22417). The phytochemical characterization of HEMKLE was performed using liquid chromatography-mass spectrometry (LC-MS). Following this, an in-silico molecular docking analysis was performed using Maestro Schrodinger software, and an in-vivo study was conducted. For the in-vivo study, female SD rats were divided into four different groups. Group I (C), Group II (DMBA), Group III (HEMKLE), and Group IV (HEMKLE + DMBA). Histopathogy, oxidative and antioxidant status, immunohistochemistry of estrogen receptor-α, TUNEL assays, mRNA and protein expression of apoptotic pathway genes were conducted in in-vivo study.
RESULTS: In LC-MS, major phytochemical constituents including flavonoids and carbazole alkaloids were identified. In-silico docking study revealed the strong binding affinity between the identified compounds with caspase-3. Additionally, koenine displayed the highest binding affinity/minimum energy of -9.21 kcal/mol with 6BDV as compared to other phytochemicals. Furthermore, in-vivo experimentation revealed that HEMKLE administration in Group IV(HEMKLE + DMBA) significantly inhibits the tumor incidence and volume as compared to alone DMBA treated group. The antioxidant action of HEMKLE was proven from the in-vivo analysis of antioxidant marker enzymes, histopathology, immunohistochemistry of ER-α studies. Further, increase number of TUNEL positive cells was observed in co-treated animals as compared to alone DMBA treated animals. In Group IV (HEMKLE + DMBA), upregulated expression of pro-apoptotic genes and downregulated expression of anti-apoptotic gene were observed when compared to Group II(DMBA) suggested the apoptotic effect of HEMKLE.
CONCLUSION: The results of the present study provide clear evidence of the chemopreventive capabilities of HEMKLE in rats with DMBA-induced breast cancer. The observed outcomes could potentially be attributed to the existence of diverse phytochemicals within the HEMKLE.
BACKGROUND: Many surgeons have begun learning about colorectal surgery using laparoscopy rather than laparotomy. The domains of four-step technique training program (DOF) for laparoscopic colorectal surgery have been designed and implemented by our institute since 2011, and they are expected to provide a safe and effective program for trainees with limited experience in laparoscopic colorectal surgery.
METHOD: The DOF were established with standard surgical procedures, a four-step technique, and learning passports using point credits after the procedure was completed. Patients who underwent minimally invasive colorectal resection at the Chang Gung Memorial Hospital between January 2013 and April 2019 were enrolled.
RESULTS: Overall, 2604 and 478 patients were enrolled in the non-training and training groups, respectively. Multivariable logistic regression analysis revealed that the postoperative short-term outcomes were not significantly associated with the training or non-training groups. However, the training group had a significantly longer operative time than the non-training group in the linear regression model. Once the trainee passed the proficiency point (passed 100 points or 30 cases), no significant difference in postoperative short-term outcomes was found between the patients in the non-training and training groups that underwent the entire surgery performed by the trainee.
CONCLUSION: When patients' safety was evaluated in the training cases under the DOF, no higher rates of postoperative morbidity and mortality were found compared to those in cases performed by experienced surgeons. Additionally, trainees who passed the proficiency point during DOF could safely perform the entire laparoscopic colorectal surgery under supervision without further adverse effects on the patients.
This study deals with preparing and characterizing polyvinyl alcohol/egg white/montmorillonite bionanocomposite hydrogels as antibacterial drug delivery systems. The cyclic freezing/thawing method was utilized to fabricate the hydrogels. To study the performance of the prepared hydrogels as drug delivery systems, amoxicillin, as a model antibiotic drug, was loaded into the hydrogels by mixing with the precursor polymer solution and gelation. From the diverse microstructural characterization techniques, i.e. XRD, SEM, AFM, DLS, and gel fraction estimation, it was possible to infer that montmorillonite has been successfully incorporated into the hydrogel network and acted as an additional crosslinker to bind the chains of egg white and polyvinyl alcohol. Scrutinizing the physical properties of the produced hydrogels demonstrated that increasing incorporated montmorillonite content adversely affects the prepared hydrogels' swelling ability and prolongs their dehydration period. Additionally, the Swelling characteristics of the hydrogels were evaluated at different pHs. Results showed an increase in the swelling ability of all samples by raising the pH value of the medium. Additionally, it was proved that both swelling and dehydration of the hydrogels follow non-Fickian diffusion. In vitro drug delivery experiments demonstrated that the cumulative fractional release of amoxicillin was adversely dependent on the amount of incorporated montmorillonite into the hydrogels and positively dependent on the pH of the release solution. It was also found that, in all examined samples, the mechanism by which the release of clindamycin happens is non-Fickian or anomalous transport.
This is a cross-sectional study conducted at University Medical Center Ho Chi Minh City. The patients were included in our study when patients were more than 18 years old and were able to comprehend Vietnamese language. The patients were excluded from study if the patients were unconscious and not oriented. On the procedural day, when the patients were in waiting room at DSA unit, investigators distributed a self-administer questionnaire to patients who had accepted to participate. The questionnaire is constructed from three parts, namely, demographics, perioperative factors, and the anxiety scale. Investigators employed "The Pre-operative Intrusive Thoughts Inventory (PITI)" as a tool to measure the anxiety scale. PITI 20 comprises twenty questions. This valid and reliable tool has Cronbach's Alpha score of 0.91. The English questionnaire was adapted and translated into the Vietnamese language and back to English. The answers contain 4 response options (4-point Likert scale ranging from "not at all" with 0 points, "some of the time" with 1 point, "often" with 2 points, and "most of the time" with 3 points). 0 and 60 points are the highest and lowest score respectively, the author of the tool reported that patients with 15 or more scores on the PITI-20 scale reliably were classified as high preoperative anxiety while participants who scored less than fifteen were classified as low preoperative anxiety. Section A: Demographic characteristics (8 questions) Section B: perioperative factors (4 questions) Section C: Pre-operative Intrusive Thoughts Inventory (PITI) anxiety scale (20 questions).

Categorical and nominal variables were presented as percentages and continuous variables as means and standard deviations. Noncontinuous variables were compared using the chi-square test and continuous variables using Student's t-test. Independent variables were identified via logistic regression. A two-sided p-value of \<0.05 was considered to indicate statistical significance.
Serious, including fatal (18/442; 4%), infections occurred in 31% of patients receiving COPIKTRA 25 mg BID (N = 442). The most common serious infections were pneumonia, sepsis, and lower respiratory infections. Median time to onset of any grade infection was 3 months (range: 1 day to 32 months), with 75% of cases occurring within 6 months. 

Treat infections prior to initiation of COPIKTRA. Advise patients to report any new or worsening signs and symptoms of infection. For grade 3 or higher infection, withhold COPIKTRA until infection has resolved. Resume COPIKTRA at the same or reduced dose [see Dosage and Administration (2.3)].

Serious, including fatal, Pneumocystis jirovecii pneumonia (PJP) occurred in 1% of patients taking COPIKTRA. Provide prophylaxis for PJP during treatment with COPIKTRA. Following completion of COPIKTRA treatment, continue PJP prophylaxis until the absolute CD4+ T cell count is greater than 200 cells/µL. Withhold COPIKTRA in patients with suspected PJP of any grade, and permanently discontinue if PJP is confirmed. 

CMV reactivation/infection occurred in 1% of patients taking COPIKTRA. Consider prophylactic antivirals during COPIKTRA treatment to prevent CMV infection including CMV reactivation. For clinical CMV infection or viremia, withhold COPIKTRA until infection or viremia resolves. If COPIKTRA is resumed, administer the same or reduced dose and monitor patients for CMV reactivation by PCR or antigen test at least monthly [see Dosage and Administration (2.3)].
OBJECTIVES: To describe and assess the feasibility of an ultrasound-guided technique for intra-articular injection of the costovertebral joints, in an unembalmed cadaveric specimen, utilizing fluoroscopy and cone beam computerized tomography for confirmation of contrast spread and needle tip position, respectively.
METHODOLOGY: A single unembalmed cadaveric specimen was obtained. A single interventionist performed the placement of the needles under ultrasound guidance. Contrast dye was then injected through each of the needles under real-time fluoroscopy. Finally, the specimen was submitted to a cone beam computerized tomography with 3-dimensional acquisition and multiplanar reformatting to assess final needle tip position relative to the costovertebral joints.
RESULTS: In total, 18 spinal needles were placed under ultrasound guidance. Fluoroscopy showed 4 distinct patterns of contrast spread: intra-articular in the costovertebral joint (13 levels in total), epidural (1 level), intra-articular in the facet joint of the target level (3 levels), and undetermined (1 level). Cone-beam computerized tomography confirmed 13 out of 18 needles to be adequately placed in the costovertebral joints (72% of the total) and 5 out of the 18 needles to be misplaced: 3 needles were placed in the facet joint of the target level, and 2 needles were placed in the epidural space.
CONCLUSIONS: This study suggests that, when performed by experienced interventionists, this technique has an accuracy rate of 72%. Further studies are warranted before these results can be extrapolated to daily clinical practice.
The invention discloses an insole which comprises an insole body. The insole body is internally provided with a hollow containing space, and a filling layer is laid in the hollow containing space. The filling layer internally comprises the following powered components: 5 g of azedarach, 8 g of apocynum venetum root, 6 g of jackfruit peel, 1 g of butterfly orchid petal, 1 g of kaffir lily leaf, 0.01 g of fructus cnidii, 0.5 g of bentonite and 0.5 g of copper sulfate powder. Compared with the prior art, the insole can well eliminate and inhibit dermatophytosis and foot odor fungi, after a patient who has the severe dermatophytosis and the foot odor uses the insole for two months continuously, the dermatophytosis and the foot odor can be thoroughly and radically treated and do not relapse. In addition, the insole only needs to be arranged in a daily-worn shoe in a cushioned mode, repeated smearing like ointments is not needed, use is convenient, the function of externally treating the dermatophytosis and the foot odor can be achieved, in addition, the Yongquan acupoint can be stimulated through the plantar acupoints to regulate the conception and governor vessels, and therefore the purpose of regulate the viscera is achieved. When the insole is used for a long time, the symptoms of ice cold of the foot and the night sweat on the sole can be effectively relieved, the spleen and the stomach can be regulate, and the toxic and side effects do not exist.
Described herein are RAS-targeted therapeutics comprising a recombinant molecule of formula: x-C-y-DTA-DTB, wherein x is a polypeptide or absent; C is a cargo polypeptide comprising Ras/Rap1 -specific endopeptidase (RRSP); y comprises a polypeptide, a linker, or is absent; DTA is a diphtheria toxin enzymatic fragment comprising SEQ ID No: 26; and DTB is a diphtheria toxin translocation fragment comprising SEQ ID No: 4, wherein the DTA is linked to the DTB by a disulphide linkage. Methods and uses for treatment of a disease or disorder caused by increased RAS activity in cells are disclosed. In some embodiments, the recombinant molecule results in surprisingly efficacious delivery of RRSP and/or reduction of RAS, e.g., to single-digit picomolar concentrations in vitro. The methods or uses may be for treatment of a cancer caused by increased RAS activity, e.g. caused by constitutively activating RAS mutations. The cancer may be pancreatic cancer.