anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is also a major risk factor for ischemic stroke. The main objective of our study was to identify direct and indirect costs of AF and AF-related stroke in Slovakia.
METHODS: We conducted a retrospective population-based study of AF and stroke related costs both from the third-party healthcare payers and societal perspective. The prevalence and incidence of AF and stroke were determined from central government run healthcare database. Further we estimated both indirect and direct costs of AF and stroke. All costs and healthcare resources were assessed from 2015 through 2019 and were expressed in the respective year.
RESULTS: Over the 5-year study period, the prevalence of AF increased by 26% to a total of 149,198 AF cases in 2019, with an estimated total annual economic burden of €66,242,359. Direct medical costs accounted for 94% of the total cost of AF. The total cost of treating patients with stroke in 2019 was estimated at €89,505,669. As a result, the medical costs of stroke that develops as a complication of AF have been estimated to be €25,734,080 in 2019.
CONCLUSIONS: Our study shows a substantial economic burden of AF and AF-related stroke in Slovakia. In view of the above, both screening for asymptomatic AF in high-risk populations and effective early management of AF with a focused on thromboprophylaxis rhythm control should be implemented.
The invention provides an acaricide for treating sarcoptes suis. The acaricide consists of fenvalerate, spirodiclofen, a cosolvent, a surfactant, a transdermal agent, a pour-on solution and ethanol, wherein the cosolvent is ethyl acetate; the surfactant is Tween-80 or compound phosphate ester; the transdermal agent is menthol; the pour-on solution is tangerine peel active principle acetate. The cosolvent is dimethylbenzene, and the surfactant is the Tween-80. The major component of the acaricide is 20% of fenvalerate which is mainly used for tagging out sarcoptic mites and blood sucking insects and has the functions of stomach poisoning and dispelling. Medicaments enter the nerve systems of mites after being contacted with the mites, so that the mites become highly excited, shake, rapidly turn to general anesthesia and paralysis, and die finally. Thus, the acaricide can be used for killing the sarcoptes suis, and has good killing effects on lice, fleas, ticks, horseflies, mosquitoes, flies and various ova.
The invention relates to a synthetic method of MACAmide. The method includes following steps: with a fatty acid and benzylamine or m-methoxybenzylamine as reaction raw materials, mixing the raw materials in a dichloromethane solution in which HOAt, EDC.HCl and DIPEA are dissolved; performing a reaction with stirring; washing a reaction product with water; and drying a substance being undissolved in water to obtain the MACAmide. The method is simple in processes and the raw materials are easy to obtain. Operation conditions of the method are easy to control. The reaction product can reach a purity of 95% without purification. The invention provides basis for industrialized synthesis of the MACAmide. In addition, the MACAmide has effects of enhancing male reproductive ability and treating male sexual dysfunction. The invention provides market prospects to application of the MACAmide.
Esophageal variceal bleeding is one of the main causes of death in cirrhosis patients. Prevention of bleeding events, including primary and secondary prophylaxis, is very important for reducing the mortality of variceal bleeding. Terlipressin and octreotide can effectively control bleeding with few side effects, which has been recommended by Baveno V in treatment of acute variceal bleeding. Terlipressin and high dose octreotide will be administered to the patients with cirrhosis related esophageal varices when they undergo hepatic venous pressure gradient measurement. Changes from portal and systemic hemodynamics will be observed to evaluate the safety and effects of terlipressin and high dose octreotide as well as to determine wether patients respond to them. The results can be served as clinical evidence for preventing re-bleeding through long-acting terlipressin and octreotide in the future.
Homeless parolees pose a particular challenge for successful reentry into the community as they have underlying mental health issues combined with substance use and abuse and must contend with unstable housing situations, disorganized lives, unemployment, and limited access to health care and social services. Generally about 50% of all parolees scheduled to enroll in community-based drug treatment fail to enroll and less than 10% of enrollees actually complete treatment. Not surprisingly, about two-thirds of all individuals on parole are rearrested and return to custody within three years of release from prison. Recent data also revealed homeless persons who were least likely to complete a Hepatitis A/B (HAV/HBV) vaccine series were young (\< 40) men who had been discharged from prison. Therefore, it is critical to engage paroled adults in comprehensive intervention programs that not only protect them from hepatitis B, but also reduce risky behavior, promote access to health care, social and employment services, and enable positive coping and communication skills.

Building upon advice from community partners who have successfully treated parolees and the research team's experience with hepatitis vaccination work, this study is designed to conduct a prospective, three-group study that randomly assigns 700 ready-for-discharge parolees, scheduled to enter a community residential drug treatment program, to enter one of three groups: 1) a PCPC (Parolee Comprehensive Care + Phone Coaching Program), which includes nurse case management and specialized hepatitis education sessions and referrals, the HAV/HBV vaccination series (to all eligible) and coach-facilitated mentoring (mostly by cell-phone); 2) a Parolee Brief Hepatitis Education + HBV vaccination + Phone Coaching (PBCP) Program, which includes brief hepatitis/HIV education, the HAV/HBV vaccination and coach-facilitated mentoring; or 3) a Usual Care (UC) control program, which includes brief general health information, and the HAV/HBV vaccine. This study will advance the research team's knowledge about drug treatment and HBV vaccine completion and recidivism among homeless parolees. Findings from this study can inform targeted interventions and lay the groundwork for health policy decisions that may impact hepatitis and HIV risk reduction and recidivism in this group who are a reservoir for these viruses in the general population, and are returning to prison at unprecedented numbers.
The invention relates to a traditional Chinese veterinary drug for curing endometriosis of dairy cows after delivery and a preparation method thereof. The traditional Chinese veterinary drug comprises the following ingredients, by weight, 15-25 parts of motherwort, 10-20 parts of dandelion, 5-15 parts of angelica; 5-10 parts of epimedium, 5-9 parts of fried folium artemisiae argyi, 5-7 parts of fried bighead atractylodes rhizome, 4-8 parts of Codonopsis pilosula, 4-8 parts of astragalus membranaceus, 4-8 parts of hawthorn, 4-7 parts of Semen Cuscutae, 3-8 parts of folium isatidis, 3-5 parts of Radix Ophiopogonis, 2-5 parts of fructus aurantii immaturus, 2-4 parts of peach seed, 2-4 parts of Mangnolia officinalis, 2-3 parts of safflower, 1-3 parts of lonicera japonica and 1-2 parts of liquorice. One or more components selected from pericarpium citri reticulatae, Pinellia tuber, trogopterus dung, radix rehmanniae preparata, forsythia and rhizoma zingiberis can be added. The traditional Chinese veterinary drug for curing endometriosis of dairy cows after delivery belongs to a natural pure traditional Chinese medicinal preparation. The method for curing endometriosis of dairy cows after delivery by the use of the traditional Chinese veterinary drug is simple and easy to operate, has remarkable effects and has no side effect. By the use of the traditional Chinese veterinary drug, there is no drug residue in milk, and cows can absorb the drug well if the drug is taken orally. The technology is simple and suitable for industrial production. The drug is simple, convenient and fast to use, and is more suitable for curing endometriosis of dairy cows after delivery on a large-scale farm than other dosage forms.
PROBLEM TO BE SOLVED: To produce the subject pharmaceutical preparation useful for the reduction of gastric mucosal lesions and treatment, etc., of acute gastritis, chronic gastritis, gastric ulcer, etc., by emulsifying teprenone in the presence of a fatty acid triglyceride and a sucrose ester of a fatty acid and forming an emulsion. SOLUTION: This pharmaceutical preparation of teprenone for oral administration is obtained by using the teprenone as an active ingredient and emulsifying the teprenone in the presence of a fatty acid triglyceride composed of a triglyceride or the like of a 4-15C fatty acid and a sucrose ester of a fatty acid having 1-19.5 value of hydrophile-lipophile balance(HLB) and 10-22 carbon atoms in the fatty acid moiety and forming an emulsion. The content of the teprenone is 0.1-10 wt./vol.% based on the total amount of the emulsion and the content of the fatty acid triglyceride is 0.05-5 pts.wt. based on 1 pt.wt. teprenone. The content of the sucrose ester of the fatty acid is 0.1-5 pts.wt. based on 1 pt.wt. teprenone.  The resultant pharmaceutical preparation is useful for reducing gastric mucosal lesions (erosion, hemorrhage, eruption or edema), treatment or the like of acute gastritis, the acute exacerbation phase of chronic gastritis or gastric ulcer.
The invention provides a carbon-loss cholesteric aldehyde, a preparation method and application thereof. The carbon-loss cholesterin is a compound shown as a formula (I), or a salt or stereoisomer thereof. Wherein R is  1  、R  2  Respectively and independently select hydrogen and C  1  ～C  6  Alkyl, halogen, hydroxy, carboxy, aldehyde, amino or nitro. The carbon-loss cholesterin has good antibacterial activity, particularly has good inhibition effect on clostridium difficile, and can be used for preparing medicines for inhibiting clostridium difficile. Meanwhile, the carbon-free cholesterol-free aldehyde can be used as a starting material to prepare carbon-free chenodeoxycholic acid, carbon-free cholesterol and chenodeoxycholic acid, and the yield is high and superior to the prior art. In addition, the invention provides a preparation method of various carbon-loss cholesterin, the preparation method has high yield and purity, and the raw material of the preparation method, namely the duck cholic acid, has wide sources and low cost, opens up an industrial method for utilizing industrial waste, namely the duck cholic acid, waste, and ensures that the preparation method is more feasible in industrialization.
FIELD: medicine, endocrine gynecology. SUBSTANCE: invention proposes the curative starvation for 10-14 days and an intravenous infusion of potassium chloride solution beginning from 5-6-th day of starvation and in the recovery period also. The total amount of infusion - 6-10. After the 1-st day after starvation ceasing bitemporal inductothermia in combination with infusions of sodium thiosulfate and injections of cerebrolysin are prescribed. EFFECT: enhanced effectiveness of treatment of women with anovulatory fertility at obesity. 2 ex
Transcranial direct current stimulation is a non-invasive technique of neuromodulation that is inexpensive, easy to use and more importantly shows great promise to modify cortical excitability. Application of a weak direct current through the scalp has been shown to induce polarity specific changes in the excitability of cortical neurons23. This effect of transcranial direct current stimulation was first demonstrated in the human motor cortex. Since then it has also shown to be effective for other brain regions such as visual, somatosensory or frontal regions.

The advantage of tDCS in managing concussion is that this technique can be used to focally suppress or enhance neuronal firing depending on the size and location of the applied electrodes. Thus, at different points during the trajectory of concussion, the technique can be matched to the underlying pathophysiology. For example, work by Demitras et al suggests that cathodal tDCS may be used to suppress the acute glutamatergic hyperexcitability in the acute stages of brain injury; in the subacute stage, when GABAergic activity is excessive, anodal tDCS may increase excitability to counter these aberrant GABAergic effects. In the chronic stage, brain stimulation coupled to rehabilitation may enhance behavioral recovery, learning of new skills and cortical plasticity. Thus far, one pilot study has shown that a single session of anodal tDCS over the dorsolateral prefrontal cortex was associated with improvements in attention in adults with chronic TBI.
An alimentary canal supporting stand covered by the frame medicine membrane, belonging to the medical and medical appliance technique field. The first structure form of this invention comprises: supporting stand, back lining layer and multi-layer frame medicine membrane, the back lining layer is covered on the surface of the supporting stand, the back lining layer clings tightly to the supporting stand, and the multi-layer frame medicine membrane clings tightly to the back lining layer. The second structure form of this invention comprises: supporting stand and multi-layer frame medicine membrane, the multi-layer frame medicine membrane is covered on the supporting stand surface, and clings tightly to the supporting stand. The third structure form of this invention comprises: supporting stand, back lining layer, multi-layer frame medicine membrane and protective layer, the protective layer is installed on the multi-layer frame medicine membrane layer. The fourth structure form of this invention comprises: supporting stand, back lining layer, multi-layer frame medicine membrane and protective layer, the protective layer is installed on the multi-layer frame medicine membrane layer. The invention possesses the function of mechanical expansion, it can make the medicine act on the pathology tissue or the near place, thus provides medicine partly and slowly in the long run.
Lowering total cholesterol and improving of blood lipid spectrum composition as seen in a decrease of low and very low density lipoprotein levels, triglycerides and Lipoprotein a, and an increase in high density lipoproteins through taking fumarate and/or fumarates and B vitamins. The fumarate is any of fumaric acid, neutral or acidic sodium fumarate, potassium fumarate, ammonium fumarate, fumarate of a general formula Fum-Me-Fum.nH 2 O, where Fum—fumaric acid anion, Me—zinc, calcium or magnesium, n=0-8 or mixture of these. The B group can be B12, B6, B2, preferably, at least two of these. Preferably also including at least one amino acid from the following: glycine, L-glutamic acid and/or its salts, L-arginine and/or its salts, L-carnitine and/or its salts, asparagine and/or its salts. Preferably also succinic, citric or isocitric acid and/or their salts. Preferably also including other vitamins, fillers, ballast substances, flavors, colors, sugars, oils.
BACKGROUND: Chronic obstructive pulmonary disease (COPD), characterized by high-energy metabolism, often leads to malnutrition and is linked to exacerbations. This study investigates the association of malnutrition-related body composition and handgrip strength changes with exacerbation frequencies in COPD patients.
METHODS: We analyzed 77 acute exacerbation COPD (AECOPD) patients and 82 stable COPD patients, categorized as frequent and infrequent exacerbators. Assessments included body composition, handgrip strength, nutritional risk, dyspnea scale, and COPD assessment.
RESULTS: Among AECOPD patients, there were 22 infrequent and 55 frequent exacerbators. Infrequent exacerbators showed better muscle parameters, extracellular water ratio, phase angle, and handgrip strength. Significant differences in intracellular water, total cellular water, protein, and body cell mass were observed between groups. Logistic regression indicated that extracellular water ratio (OR = 1.086) and phase angle (OR = 0.396) were independently associated with exacerbation risk. Thresholds for exacerbation risk were identified as 0.393 for extracellular water ratio and 4.85° for phase angle. In stable COPD, 13 frequent and 69 infrequent exacerbators were compared, showing no significant differences in weight, muscle, and adipose parameters, but significant differences in extracellular water ratio, phase angle, and handgrip strength.
CONCLUSIONS: These findings suggest that increased exacerbations in COPD patients correlate with higher extracellular water ratios and lower phase angles.
This umbrella review synthesizes data from 17 meta-analyses investigating the comparative outcomes of catheter ablation (CA) and medical treatment (MT) for atrial fibrillation (AF). Outcomes assessed were mortality, risk of hospitalization, AF recurrence, cardiovascular events, pulmonary vein stenosis, major bleeding, and changes in left ventricular ejection fraction (LVEF) and MLHFQ score. The findings indicate that CA significantly reduces overall mortality and cardiovascular hospitalization with high strength of evidence. The risk of AF recurrence was notably lower with CA, with moderate strength of evidence. Two associations reported an increased risk of pulmonary vein stenosis and major bleeding with CA, supported by high strength of evidence. Improved LVEF and a positive change in MLHFQ were also associated with CA. Among patients with AF and heart failure, CA appears superior to MT for reducing mortality, improving LVEF, and reducing cardiovascular rehospitalizations. In nonspecific populations, CA reduced mortality and improved LVEF but had higher complication rates. Our findings suggest that CA might offer significant benefits in managing AF, particularly in patients with heart failure. However, the risk of complications, including pulmonary vein stenosis and major bleeding, is notable. Further research in understudied populations may help refine these conclusions.
BACKGROUND: Non-small cell lung cancer (NSCLC) is a highly prevalent and fatal form of lung cancer. In China, Aconiti Lateralis Radix Praeparata (Fuzi in Chinese), derived from the lateral root of Aconitum carmichaeli Debx. (Ranunculaceae, Aconitum), is extensively prescribed to treat cancer in traditional medicine and clinical practice. However, the precise mechanism by which Fuzi treats NSCLC remains unknown.
PURPOSE: This article aims to assess the efficacy of Fuzi against NSCLC and elucidate its underlying mechanism.
METHODS: Marker ingredients of Fuzi decoction were quantified using UPLC-TSQ-MS. The effectiveness of Fuzi on NSCLC was evaluated using a xenograft mouse model. Subsequently, a comprehensive approach involving network pharmacology, serum metabolomics, and 16S rDNA sequencing was employed to investigate the anti-NSCLC mechanism of Fuzi.
RESULTS: Pharmacological evaluation revealed significant tumour growth inhibition by Fuzi, accompanied by minimal toxicity. Network pharmacology identified 29 active Fuzi compounds influencing HIF-1, PI3K/Akt signalling, and central carbon metabolism in NSCLC. Integrating untargeted serum metabolomics highlighted 30 differential metabolites enriched in aminoacyl-tRNA biosynthesis, alanine, aspartate, and glutamate metabolism, and the tricarboxylic acid (TCA) cycle. Targeted serum metabolomics confirmed elevated glucose content and reduced levels of pyruvate, lactate, citrate, α-ketoglutarate, succinate, fumarate, and malate following Fuzi administration. Furthermore, 16S rDNA sequencing assay showed that Fuzi ameliorated the dysbiosis after tumorigenesis, decreased the abundance of Proteobacteria, and increased that of Firmicutes and Bacteriodetes. PICRUSt analysis revealed that Fuzi modulated the pentose phosphate pathway of the gut microbiota. Spearman correlation showed that Proteobacteria and Escherichia_Shigella accelerated the TCA cycle, whereas Bacteroidota, Bacteroides, and Lachnospiraceae_NK4A136_group suppressed the TCA cycle.
CONCLUSIONS: This study firstly introduces a novel NSCLC mechanism involving Fuzi, encompassing energy metabolism and intestinal flora. It clarifies the pivotal role of the gut microbiota in treating NSCLC and modulating the TCA cycle. Moreover, these findings offer valuable insights for clinical practices and future research of Fuzi against NSCLC.
PROBLEM TO BE SOLVED: To obtain a substance capable of preventing induction of breast cancer. SOLUTION: This breast cancer suppressant comprises melatonin or melatonin analogue. The breast cancer suppressant is daily administered for a definite period to human male to prevent induction of breast cancer. The administration may be carried out in combination of the melatonin or melatonin analogue and progestogen and/or oestrogen. Daily dose of melatonin is 2 mg to 1,000/70 kg weight female and daily dose of progestogen is 7.5 μg to 2,500 μg and daily dose of oestrogen is 5 μg to 100 μg. The administration is carried out by vein injection or subcutaneous injection in orally or physiologically proper carrier.
PURPOSE:To obtain a hair tonic, containing a solvent extract of cultured mycelia prepared by culturing mycelia of Cordyceps sinensis Sacc. as an active ingredient and capable of suppressing alopecia, excellent in hair tonic effects and readily ensuring raw materials. CONSTITUTION:A hair tonic is obtained by using an extract of cultured mycelia prepared by artificially culturing mycelia of Cordyceps sinensis Sacc. which are naturally occurring substances with a solvent, preferably water or ethanol as an active ingredient, in the form of, e.g. (A) a solvent extract solution of the aforementioned cultured mycelia, (B) a concentrate or dried solid substance after removing part or all of the solvent from the form (A) or (C) a base for the hair tonic added to the form (A) or (B). The above-mentioned hair tonic is capable of suppressing falling of hair and alopecia, normalizing the hair and remarkably increasing the elongation rate of the hair. Since the aforementioned mycelia can be readily proliferated by culturing, raw materials can easily be ensured. Furthermore, in the case of (A) and (C), the concentration of the aforementioned extract is preferably 0.00001-30wt.% expressed in terms of dried solid substance content.