anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: The Society of Thoracic Surgeons General Thoracic Surgery Database (STS-GTSD) previously reported short-term risk models for esophagectomy for esophageal cancer. We sought to update existing models using more inclusive contemporary cohorts, with consideration of additional risk factors based on clinical evidence.
METHODS: The study population consisted of adult patients in the STS-GTSD who underwent esophagectomy for esophageal cancer between January 2015 and December 2022. Separate esophagectomy risk models were derived for 3 primary end points: operative mortality, major morbidity, and composite morbidity or mortality. Logistic regression with backward selection was used, with predictors retained in models if P < .10. All derived models were validated using 9-fold cross-validation. Model discrimination and calibration were assessed for the overall cohort and specified subgroups.
RESULTS: A total of 18,503 patients from 254 centers underwent esophagectomy for esophageal cancer. Operative mortality, morbidity, and composite morbidity or mortality rates were 3.4%, 30.5%, and 30.9%, respectively. Novel predictors of short-term outcomes in the updated models included body surface area and insurance payor type. Overall discrimination was similar or superior to previous STS-GTSD models for operative mortality (C statistic = 0.72) and for composite morbidity or mortality (C statistic = 0.62), Model discrimination was comparable across procedure- and demographic-specific subcohorts. Model calibration was excellent in all patient subgroups.
CONCLUSIONS: The newly derived esophagectomy risk models showed similar or superior performance compared with previous models, with broader applicability and clinical face validity. These models provide robust preoperative risk estimation and can be used for shared decision making, assessment of provider performance, and quality improvement.
A Taylor Spatial Frame should consist of 2 rings with 4 half pins/K-wire attached to each ring. If possible 3, not hydroxyapatite-coated, half pins and one K-wire should be attached to each ring. The half pins/K-wire should be spread in distance and direction for optimum stability.
Participants in the intervention group will receive access to e-Hematological Oncology Parent Education (eHOPE) and usual care. Participants will need to complete 4 self-paced activities over a period of 8 weeks. Each activity will be released at 2-weekly intervals.
PURPOSE:To provide a skin cosmetic containing sodium gamma-hydroxy-butyrate, effective in promoting the function of the skin, ameliorating the chapped skin, improving keratin and quickening the turn-over of horny layer, having excellent effect to prevent the aging of the skin such as the skin-beautifying effect and useful as a lotion, etc. CONSTITUTION:The objective cosmetic contains sodium gamma-hydroxybutyrate (abbreviated as SGHB) which is a known substance applied as a remedy for cerebral arteriosclerosis. A skin cosmetic compounded with SGHB promotes the blood flow in the skin to promote the function of the skin, ameliorates or improves the natural functions of the skin to keep the skin in healthy state and exhibits excellent effect especially by the application to aged skin. The amount of SGHB is 0.05-2.0wt.% based on the total skin cosmetic. The skin cosmetic can be used in the form of lotion, milky lotion, cream, pack, etc. The cosmetic may be compounded with colorant, flavor, antiseptic, surfactant, pigment and antioxidant in addition to the above components.
A breakaway interface between radiological information systems, imaging equipment and picture archive and communications systems has automated filtering and handling of multiple study work orders or affiliated work orders, while passing single study work orders through unaltered. The work orders are processed by the breakaway interface to consolidate multiple procedure or multiple study work orders into a single super order, which is then communicated, preferably using DICOM standard protocol, to an imaging machine. The imaging machine returns a single image sequence, and the breakaway interface will then break images away from the single image sequence into a plurality of grouped image sequences. The preferred grouping is based upon anatomical regions, and separate but adjacent anatomical regions will preferably share one or more images at the boundary between the adjacent regions. The exact number of shared images may preferably be preset at the system level. A number of different techniques for analyzing the single image sequence are proposed individually or in combination, including histogram analysis, peak finding techniques, moments of order analysis, evaluating information from one or more previous analyses, and evaluating image sequence series information to distinguish discrete imaging procedures.
Methylphenidate hydrochloride in extended-release tablets is more slowly but as extensively absorbed as in the regular tablets. Bioavailability of the UCB methylphenidate hydrochloride extended-release tablet was compared to a sustained-release reference product and an immediate-release product. The extent of absorption for the three products was similar, and the rate of absorption of the two sustained-release products was not statistically different.

In another reported study with a brand of Methylphenidate HCl sustained-release, the time to peak rate in children was reported as 4.7 hours (1.3 - 8.2 hours) for the sustained-release tablet dosage form and 1.9 hours (0.3 - 4.4 hours) for immediate release tablets. An average of 67% of a sustained-release tablet dosage form was excreted in children compared to 86% in adults.

In a clinical study involving adult subjects who received Extended-release (ER) tablets, plasma concentrations of methylphenidate hydrochloride's major metabolite appeared to be greater in females than in males. No gender differences were observed for methylphenidate hydrochloride's plasma concentration in the same subjects.
NEW MATERIAL:A compound shown by the formulaI(A is isothiazolyl which may have a substituent group; R is H or lower alkyl). EXAMPLE:7-( 4-Cyano-3-hydroxyisothiazole-5-yl )thioacetamido-3-( 1-methyl-tetrazole-5-yl)thiomethyl-DELTA<3>-cephem-4-carboxylic acid. USE:An antibacterial agent. Effective against both Gram-positive and Gram- negative bacteria. Useful as an additive for feed, preservative for food and chemical industrial products, etc. as well. PROCESS:A 7-haloacetamido-cephalosporin derivative shown by the formula II (X is halogen) or its salt is reacted with an alkali metal salt of mercaptoisothiazole which may have a substituent group at room temperature-under cooling, preferably in the presence of base, to give a compound shown by the formulaI.
Aging in female reproductive cells, particularly cumulus granulosa cells, is associated with various dysfunctions that compromise fertility. Melatonin, a hormone primarily produced by the pineal gland, is renowned for its multifaceted roles in regulating physiological processes, including sleep-wake cycles, immune function, and antioxidative defense. Melatonin's antioxidant action is mediated through direct scavenging of free radicals, upregulation of antioxidant enzymes, and improvement of mitochondrial efficiency. These properties make melatonin a promising candidate for mitigating the adverse effects of aging on cellular function. This study aims to explore the effects of melatonin supplementation on cumulus cell gene expression and in vitro fertilization (IVF) outcomes in women over 35 years old. In the study group, patients will receive melatonin supplementation for at least two months prior to their IVF cycles. In the control group, patients will proceed directly to IVF cycles without melatonin supplementation. Cumulus cells will be collected after oocyte retrieval, and gene expression will be measured. Additionally, clinical pregnancy rate, live birth rate, and miscarriage rate between the two groups will be evaluated.
Medicaments for treating diseases produced by viruses or mycoplasmas esp. neoplasts contain non-toxic cpds. unfavourable to living organisms but free from side effects, acting as oxidising agents at pH 7.0 being stable under mildly alk conditions and capable of exerting under the specific conditions of pH and redox potential of the affected cell a selective oxidising action or such cells to produce an abiotic medium within the cells giving rise to ageing and necrosis of the cells. Pref. active cpd. is e.g. benzoyl peroxide.
[FR2100796A1]
Total knee arthroplasty (TKA) is an important therapy for patients with serious knee osteoarthritis in order to improve quality of life and relieve pain. But a large number of patients who undergo this surgery experience moderate to severe postoperative pain. Previously, the investigators used single femoral nerve blockade combined with patient-controlled intravenous analgesia for postoperative analgesia for patients after TKA. Although this method provides acceptable analgesia, the incidence of opioid-associated side effects is relatively high. Low-dose epidural morphine is commonly used in postoperative analgesia after cesarean section, and the effect of single dose morphine lasts more than 20 hours, with low incidences of itching, nausea, vomiting, and respiratory depression. The investigators hypothesize that, for patients undergoing TKA, the addition of low-dose epidural morphine to single femoral nerve block and intravenous opioids can improve the postoperative analgesia, reduce the consumption of intravenous opioids and decrease opioid-associated side effects.
Agents for preventing physiological disorders (esp. disorders of milk output, of metabolism and of fertility) in dairy cows in the puerperal phase consist of a supplementary feed contg. 150-600 g raw protein per animal per day, the protein cpds. being protected against premature degradation in the rumen. The new agents overcome protein deficiency experienced by dairy cows during the puerperal phase (10 weeks following calving or onset of lactation) attributed to increased energy requirement at this time accompanied by poor absorption of nutrients. The protein content of milk from cows fed the supplementary protein is higher than that of cows fed no supplementary protein, and the actual amt. of milk can be increased. Agents also prevent reproductive disorders and metabolic disorders that can otherwise arise from protein deficiency during the puerperal phase. Administration of the supplementary protein in a form protected against degradation by rumen bacteria ensures that all of the administered protein is physiologically available to the cow.
Subjects in the intervention group will receive standard physiotherapy care and an additional volunteers session once a day for at least 3 times during their stay in the hospital. The volunteer will set up the TKR exercise video for the subjects, then supervise or guide the subjects with the exercises.
PROBLEM TO BE SOLVED: To prepare a cosmetic, utilizing charcoal and capable of beautifying the skin by mainly activating dermal cells of a face. SOLUTION: This cosmetic utilizing charcoal is prepared by combining a dense charcoal powder made of Quercus phillyraeoides A. Gray, having a high specific surface area and moisture and odor adsorptivity, rich in adsorptivity, containing innumerable microorganisms, present in small holes and capable of decomposing odoriferous substances and having deodorizing actions on conversion thereof into odorless substances and further containing active electrons in an especially large amount capable of feeding the electrons to the surrounding materials with pyroligneous acid, a ceramic powder, an enzyme and magnetic water. When the resultant cosmetic is used to continue face washing or pack, foulings on the face are removed to activate dermal cells and horny substances on the dermal surface are softened to be astringent.  Thereby, wrinkles and stains of the skin are removed to whiten the color and produce luster and moistness. Furthermore, the cosmetic is extremely inexpensive as compared with a conventional one without any adverse effects such as damage to the skin.
OBJECTIVE: Proliferative verrucous leukoplakia (PVL) has high rates of malignant transformation into oral squamous cell carcinoma (OSCC), but the clinical and evolutionary pattern of OSCC from PVL (PVL-OSCC) is more favorable than that of OSCC not preceded by PVL (OSCC). Here, we aimed to explore the pathophysiologic differences between PVL-OSCC and OSCC through transcriptomic and DNA methylation analyses.
MATERIALS AND METHODS: In this case-control study, oral biopsies from 8 PVL-OSCC and 10 OSCC patients were obtained for global sequencing using RNAseq and a genome-wide DNA methylation analysis via the Infinium EPIC Platform (graphical abstract).
RESULTS: One hundred and thirty-three differentially expressed genes (DEGs) were detected, 94 of them upregulated in OSCC. Most of these genes were previously described in cancer and associated with prognosis. The integrative analysis revealed 26 DEGs, corresponding to 37 CpGs, whose promoters were regulated by DNA methylation. Twenty-nine of the CpGs were found as hypermethylated in PVL-OSCC. Only 5 of the genes that were aberrantly methylated and differentially expressed were upregulated in PVL-OSCC patients, whereas 21 were underexpressed.
CONCLUSIONS: PVL-OSCC patients presented lower expression of cancer-related genes. Hypermethylation of the promoter region of many genes was also noticed, indicating that DNA methylation could be a regulatory mechanism.
The iRTP was based on recovery experiences (psychological detachment, relaxation, mastery, and control), converted into a recovery training intervention inspired by Hahn et al. (2011). The iRTP comprised five modules distributed over five weeks, with modules lasting 60-120 minutes per week.
PURPOSE:A carcinostatic agent, containing eisenin (tripeptide) as an active constituent, and capable of activating attached cells and floating cells, and exhibiting immunological enhancing and carcinostatic action. CONSTITUTION:A carcinostatic agent containing a compound of the formula (pyroglu is pyroglutamic acid; Glu is glutamic acid; Ala is alanine) as an active constituent, and having immunological enhancing carcinostatic action. The eisenin of the formula is extracted from a seaweed Eisenia bicyclis, and a colorless long needlelike crystal having a silky gloss, contracts a little at 180 deg.C melting point, melts and decomposes at 225-226 deg.C, and the aqueous solution is acidic. The eisenin canbe formed into a fine powder due to the crystallinity thereof and is soluble in water. Thus, the eisenin can be applied as an injection, tablet, ointment, suppository, etc. The antitumor effect of the eisenin is not only the direct effect but also the effect on the enhancement of the nonspecific immunological ability of living bodies.
A composition of matter comprising an edible organically based substance, as well as an apparatus and method of making the composition of matter is disclosed. In one embodiment, the composition of matter, apparatus and method are directed to an edible organically based powder comprising an organic material, MCT oil, and MCT oil powder. In certain embodiments, the organic material and MCT oil are mixed together, heated and agitated binding the MCT oil to the organic material and decarboxylating the compound. The decarboxylated compound is then cooled. The decarboxylated compound is then ground to a desired size (which in some embodiments may be as fine as a powder) which is then mixed with MCT oil powder to produce the edible organic substance. In certain embodiments, the organic material comprises  cannabis , and the resulting edible organic substance resulting from the disclosed process is an edible  cannabis  plant powder.
Food insecurity affects one in six households with children in the United States and disproportionately impacts those headed by women and minorities. Food insecurity is associated with childhood obesity, asthma, anxiety and depression and behavioral problems, and thus contributes to health disparities. While food insecurity likely contributes to poor health through its effect on diet, such a simplistic understanding likely obscures the effects of stress - those unique to childhood, such as Adverse Childhood Experiences including maternal depression, as well as those generally associated with the experience of poverty. To inform the mechanisms by which food insecurity ultimately affects physical and mental health outcomes in children, this study will disentangle the effects of food insecurity from those of poverty and examine effects on diet, biomarkers, weight gain, mood and behavior while considering other childhood adversities. Specifically, through a unique summertime meal provision intervention, the proposed project will isolate the experience of food insecurity in children, ages 8 to12 years, from low-income households in Providence, RI. In partnership with the YMCA of Greater Providence and the Healthy Communities Office in Providence, we will recruit 100 children over two summers. After completing a baseline assessment, participants will be randomized to receive home-delivered meals throughout the summer or to receive a weekly newsletter. Children randomized to the newsletter group will experience the natural onset of summertime food insecurity and receive a weekly newsletter on community resources that is not expected to affect food insecurity (Food Insecure Group). Those randomized to receive meals will remain food secure over the summer through receipt of weekly shipments of five breakfast and lunch meals that meet the nutrition needs of this age group (Food Secure Group). Primary endpoints include diet quality, biomarkers of Metabolic Syndrome, inflammation, and stress, BMI z-scores, and child measures of behavior and anxiety and depression symptoms. The impact of caregiver mood and stress on the health effects of food insecurity will also be explored. Ultimately, findings from this research will clarify the mechanisms by which food insecurity affects child health outcomes and inform how to more effectively prevent food insecurity.
RBD is one of the representative non-motor symptoms of PD. Patients with RBD show dream-enacting behaviors such as punching, kicking, singing, screaming, or somnambulism. These can interfere in sleep quality and increase the risk of falling down from the bed and physical injuries of both the patient and sleep partner. Therefore, qualities of life of the patient and sleep partner are negatively influenced by presence of RBD.

Clonazepam has been used for treatment of choice of RBD. However, the efficacy of clonazepam is not proven in the clinical trial. Clonazepam has several side effects that could be problematic in PD patients such as increasing fall-down risk, daytime somnolence, and cognitive decline. Melatonin is a second-line treatment option for RBD, but there has been only one randomized crossover trial that evaluated the efficacy of melatonin on RBD. Finally, there has been no study that evaluate and compare the efficacy and safety of melatonin and clonazepam for treatment of RBD.
Injection of Lucentis® (ranibizumab) into the study eye on Day 1 and monthly for five months. Patients will receive additional treatment thereafter based on re-treatment criteria.
Single arm study. Four cohorts of 5 patients will undergo neo-adjuvant SBRT for lung cancer. Eligible patients will have operable, borderline resectable lung cancer , they will be treated with SBRT, prior to undergoing surgical resection.
Patient with Metavir score of F0 will be assigned to the control group. Collected data will contain epidemiological and biological data. Blood samples with chlordecone dosage will be performed.
Sham treatment subjects will be positioned on the device in the same manner. The sham treatment will provide some sensation without active HIFEM technology. The programming for the sham treatment will have an amplitude limitation, with the setting below the therapeutic level (\<10% power).
Addiction to illicit and prescribed drugs, alcohol and tobacco is associated with a panoply of brain changes that contribute to structural and micro-structural deficits, altered metabolism and neurotransmission, and related cognitive deficits affecting executive function, decision-making, reward salience and motivation. Many of these deficits may act as barriers to recovery, compromising the same spectrum of cognitive processes that established interventions (motivational enhancement, cognitive behavioral therapy, therapeutic communities, etc.) depend on for successful outcomes. Even where there are medications that target a specific addiction (e.g., methadone for opiates), meaningful, sustained recovery relies on the acquisition of adaptive skills and strategies. As such, there is a need to develop interventions for substance use disorders that have the potential to improve health and cognitive and psychosocial functioning, and to be embraced by the treatment community. A growing body of basic and clinical research suggests that physical exercise may reduce drug use and improve cognitive-executive function, mood, and motivation. There is also a growing literature on the effectiveness of positive affirmation as a cognitive-behavioral intervention for depression and PTSD both of which frequently co-occur with addiction. Building on this, we hypothesize that a combined exercise and affirmation intervention (IntenSati) will lead to improved cognitive and psychosocial function. To test this, we propose to conduct a two-arm randomized clinical trial - in adult volunteers with a history of longstanding substance use and who are in treatment in a residential therapeutic community setting (Odyssey House) - to examine cognitive and psychosocial function before, during, and after randomization to either a twelve-week IntenSati intervention condition or to a twelve-week no-exercise/no-affirmations control condition. This is a pilot study intended to collect data on feasibility and effect size. The population and sample size were selected on the basis of likelihood to benefit from the intervention, likelihood for good adherence, and the realities of completing a low-cost pilot study within a one-year timeframe. Overall there were no substantial differences between IntenSati and TAU on measures of cognition, mood, and psychosocial functioning. Limitations include the small sample size, limited exercise intensity and capacity, missed exercise classes, dropout because of placement, work schedules and non-study-related medical conditions.
Gloreha device and standardized exercise. 12 sessions over 4 weeks (3 sessions per week).