For Virtual Platform Background: Toxic stressors including parental depression, addictions, intimate partner violence or low-income undermine parent-child relationship quality, placing children at risk for mental, emotional and behavioural (MEB) health and development problems. COVID-19 has placed unprecedented strains on already vulnerable families. Postpartum depression (PPD), for example, affects \~19% of mothers and is considered toxic to children's mental health and development because it reduces maternal sensitivity and positive responsiveness to infant/child cues and bids for caring attention. While depressed mothers benefit from support, COVID-19 has reduced depressed mothers' access, placing their children's mental health and development at heightened risk. Exposure to toxic stress increases children's risk for poor lifetime mental health trajectories. Ensuring that parents and children receive support to address the impact of toxic stress, especially given service reductions associated with COVID-19, is crucial to promote children's' mental health. Our aim is to build on the success of two CIHR funded in-person (home or clinic) intervention program designed to improve parent-child relationship quality and children's MEB health and development by transitioning to virtual delivery. In response to ceased/delayed recruitment in both study and increased demand for parent-child mental health services related to the pandemic, the research team rapidly adapted to virtual delivery in collaboration with principal knowledge user (D McNeil, Scientific Director, Maternal Newborn Child and Youth Strategic Clinical Network, Alberta Health Services). Our efforts revealed unsurmountable barriers to using commercially available technologies and affirming the need to develop and implement user-informed virtual care delivery platforms and mobile tools.

VID-KIDS Program (Video Feedback Interaction Guidance Program for Depressed Mothers and their Infants), was designed specifically to help mothers with PPD to be sensitive and responsive to their infants, an ability that is undermined by the symptoms of depression, in order to promote healthy child development. As both program have been demonstrated to be effective in clinic and home visits, both are positioned for transition to virtual formats and the timing is ripe for rapid uptake in Canada.

Methods: Using integrated knowledge transfer (iKT) and participatory design approaches, investigators will develop and pilot test a virtual program for real-world implementation, by evaluating the impact of the beta prototypes on maternal-infant interaction quality and children's MEB health development. Interdisciplinary collaboration is vital to ensure the relevant expertise to develop accessible secure, safe, user-friendly and feasible virtual mental health intervention for VID-KIDS. To ensure usability of the virtual platforms, investigators will undertake four-phase study for VID-KIDS: Phases 1 and 2: Exploratory - user engagement to identify content and explore design challenges and user preferences, followed by prototyping of interface designs; Phase 3: Software Development - iterative design sessions with users to develop MVPs; and Phase 4: Pilot Test - beta test MVPs and refine user interface designs. The impact of the beta prototypes on parent-infant interaction quality and children's mental health and development will be assessed.

Relevant Research Areas: This project directly aligns with the priority research area, Developing Innovative Adaptations of Services and/or Delivery, in that user interface design (UID) and iKT approaches will be used to: (a) adapt the innovative VID-KIDS program for virtual delivery; (b) develop virtual platforms (web-based applications) and tools (mobile apps) for flexible delivery of mental health supports for parents and training for professional facilitators; (c) integrate virtual mental health services into the primary care system to promote program uptake; and (d) design/test streamlined and intuitive virtual systems that can be easily spread and scaled. T his work will set the stage for two tri-council randomized controlled trial (RCT) grants, expanding our research into user-engaged technology-enabled delivery of needed community interventions, especially relevant to promoting the mental health of Canadian families in the COVID-19 context of physical distancing.

For VID-KIDS Program Background \& Rationale: Affecting \~19% of mothers, postpartum depression (PPD) reduces maternal sensitivity and positive responsiveness to infant cues and bids for caring attention. Infants perceive these behaviours as stressful which stimulates the hypothalamic pituitary adrenal axis, triggering cortisol release which, at persistently elevated levels, inhibits neurogenesis during critical periods of brain development. Elevated infant cortisol of infants of mothers with PPD may explain later poor child cognitive development and hyperactivity and anxiety problems into adolescence. The negative developmental outcomes from poor quality interactions and disrupted cortisol patterns underscores the urgency for intervening. Treating PPD successfully, has not consistently improved maternal-infant (M-I) interaction quality and children's development. Parent training promoting sensitive, responsive interactions may help infants of depressed mothers develop optimally. Research Question \& Objectives: Conduct a randomized controlled trial (RCT) with depressed mothers of infants aged 2-6 months designed to alter negative M-I interaction and child development associated with PPD. Objective: examine effect of the intervention, VID-KIDS ("video-feedback intervention to promote improved interactions between mothers and their kids"), on: 1) M-I interaction; 2) infant cortisol patterns, infant development, maternal symptoms of PPD, anxiety, and parenting stress. Anticipate to improve: 1) M-I interactions and infant development, infant cortisol; 2) symptoms of PPD, anxiety, parenting stress, and infant development. The investigators will conduct cost-benefit analyses. An additional objective is to collect infant buccal cells for future genetic/ epigenetic analyses. Research has suggested biological sensitivity, assessed via genotyping specific genetic variants and alleles may confound effects of interventions of this nature. Intervention may affect the epigenome, particularly the number or nature of methylated DNA sites, of treated infants differently than untreated infants that may link to infant development. This portion of the study is optional for parents-they can opt out of buccal cell collection. Methods: The study will implement a parallel group RCT compared to resource and referral program (standard care) for mothers with PPD and their infants. After baseline assessment, over the following 9-weeks, mothers randomized to the intervention will receive 3-video-feedback sessions during home visits conducted at 3-week intervals. Mothers randomized to the control condition will receive standard care. Both groups will be assessed at baseline, immediately following the 9-week treatment/standard care interval (post-test), then 2-months later (delayed post-test). Both control and intervention mothers will have access to standard care over the study period. Mothers' use of such health services will be documented. The investigators will adhere to CONSORT guidelines. Intervention description. Video-feedback interventionists will be trained by Co- PI Tryphonopoulos using a manualized curriculum of 7-themed modules offered in a 4-day workshop. Training modules will include: 1) Introduction to Video-feedback; 2) NCAST Keys to Caregiving Program; 3) Infant Engagement and Disengagement Cues (using NCAST's BabyCues: A Child's First Language Cards®; 4) Video-feedback Intervention Protocol; 5) Overview of Behaviours of Interest; 6) Case Studies; and 7) Examples of Strengths-Based Feedback.

The intervention follows an 8-step protocol:

Ice-breaking. Interventionist initiates rapport with the participant. Overview of Infant Engagement and Disengagement Cues. Using NCAST's BabyCues, interventionists review coloured photo cards that illustrate and explain the behavioural cues commonly seen in infants, including potent and subtle engaging and disengaging cues. NCAST Teaching Activity. Using the Nursing Child Assessment Teaching Scale (NCATS) protocols and elements, mothers are asked to perform a teaching task more advanced than their infant's age level. Recording Interaction. Mothers and infants are observed and video-recorded. Initial-Viewing. Specific feedback is not provided during the initial viewing. Mothers are asked to reflect on and point out any infant cues they recognize. Interventionist documents the presence or absence of infant cues and mother's response for later discussion. Second-Viewing. Interventionist and mother co-view the recorded interaction with opportunities provided for replay/slow review portions emphasizing sensitivity and responsiveness. Interventionist provides feedback: using praise reinforcing desired maternal behaviours; information on infant cues; appraisal of maternal response to infant distress; and use of cognitive growth fostering language. Third-Viewing. The final viewing, integrates all of the concepts discussed in the previous screenings, using positive reinforcement to emphasize optimal aspects of sensitivity, responsiveness and constructive feedback suggesting areas for growth. Post-viewing Debrief. Interventionist and mother conclude the video-feedback session discussing whatever interests the mother. Mothers are encouraged to make note their infants' engagement/disengagement cues and responses to these non-verbal behaviours. Video feedback sessions last 60-90min. Subsequent sessions follow same protocol (new teaching activities) and build on the previous interaction guidance discussions.