anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study aimed to assess the impact of enhanced recovery after surgery (ERAS) intervention in preventing venous thromboembolism (VTE) among postoperative lung cancer patients. Conducted from January 2022 to January 2023, the research involved 125 lung cancer patients randomly assigned to either a control group (n = 60) receiving routine care, or an ERAS group (n = 65) which received both routine care and ERAS interventions. The ERAS program comprised a comprehensive series of interventions meticulously implemented throughout the preoperative, intraoperative, and postoperative phases. Thrombotic risk assessment using the Caprini Risk Assessment Model (RAM) was conducted preoperatively and on postoperative day 5 (POD 5), with plasma D-dimer levels measured preoperatively, on POD 1, POD 3, and POD 5. Quality of life and patient satisfaction were assessed at discharge using the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire-Lung Cancer Module 13 (QLQ-LC13) and The Newcastle Satisfaction with Nursing Scale (NSNS), respectively. The ERAS group demonstrated significantly lower Caprini RAM scores on POD 5 compared to the control group, with lower D-dimer levels on POD 3 and POD 5. The incidence of VTE was lower in the ERAS group (1.54%) compared to the control group (11.67%) during hospitalization. At discharge, the ERAS group showed improved quality of life, with higher satisfaction scores for nursing care and their hospital stay. ERAS nursing interventions effectively mitigate thrombotic risk, improve D-dimer levels, enhance postoperative quality of life, and elevate patient satisfaction among individuals undergoing lung cancer surgery.
The families assigned to the wait-list control group will not receive access to the game until after 4 weeks and completion of the secondary round of testing at the lab. After the second lab visit and completion of the testing, families will be given access to the video game training exercise (on a loaned laptop), walked through the game's operation and controls, and encouraged to use it as often as they or their child like. If the child plays the game for a minimum of 20 minutes, 3 times per week, for 4 weeks, the family will be invited back to CARE for post-testing.
503,642. Gonadotropic hormones. INSTITUT DE SEROTHERAPIE HEMO-. POIETIQUE SOC. ANON. Dec. 20, 1937, No. 35301. Convention date, Dec. 19, 1936. [Class 81 (i)] Gonadotropic hormones' are obtained from the serum of pregnant mares by adding an equal volume of acidified alcohol to precipitate albuminous substances, removing the precipitate, and then adding a further quantity of alcohol to precipitate the hormones. According to an example sodium chloride is added together with the final quantity of alcohol. The hormopes may be further purified by dissolving the precipitate in dilute alkali solution, neutralization of the solution, addition of an equal volume of alcohol to precipitate impurities and addition of more alcohol to the clear solution to re-precipitate the hormones. These steps may be repeated. Water may replace the dilute alkali solution for extraction of the. hormones. The Specification as open to inspection under Sect. 91 refers also to a known process according to which acetone is added to the serum to precipitate the hormone together with albuminous substances, and the hormone is extracted from the precipitate by means of dilute alcohol. This subject-matter does not appear in the Specification as accepted.
The invention provides compound essential oil with the effects of inducing resuscitation and refreshing mind, and a preparation method and application thereof. The preparation method comprises the following steps of: borneol, storax essential oil, rose essential oil, jasmine essential oil and benzoin essential oil. The compound essential oil is prepared by utilizing the compatibility principle of monarch, minister, assistant and guide of traditional Chinese medicines, adopting borneol as a monarch drug, adopting storax essential oil as a ministerial drug, adopting rose essential oil and jasmine essential oil as assistants and adopting benzoin essential oil as guides, and can be used for relieving symptoms such as dizziness, fatigue and fatigue caused by hypoxia. The preparation method comprises the step of uniformly mixing the preparation raw materials according to the proportion. The essential oil provided by the invention is prepared by extracting plants containing natural active ingredients, the raw materials are rich, the borneol is easy to permeate the blood brain barrier, and other essential oil components can be promoted to permeate the blood brain barrier to play an anti-hypoxia role. The whole formula is scientific in proportion and strong in drug effect. Experimental study shows that the anti-hypoxia effect is remarkable.
The group will have 10 classes on a simulator using the technology of virtual reality with biofeedback "ReviVR". The total duration of the procedure is 30 minutes. Before the procedure, blood pressure and heart rate are measured, the size of the pneumatic cuffs on the feet is selected. After instructing the patient and selecting the virtual environment and the optimal speed of movement in VR, VR glasses are installed. Then rehabilitation exercises are carried out for 15 minutes. The patient moves in a virtual environment, receiving visual, auditory and tactile signals that form the correct walking pattern. At the end of the training, the VR glasses are dismantled. Then blood pressure and heart rate are measured and information about the state of health and sensations during the procedure is recorded.
PURPOSE:To obtain a safe cosmetic, containing a purified liquid extract prepared by boiling, steaming or extracting a fruit of Pseudocydonia sinensis Schneid. and removing crude fiber ingredients, having high permeability to the skin and excellent in protective action on the skin and persistence of metabolism due to skin softening action, water holding properties, etc., thereof. CONSTITUTION:A fruit of Pseudocydonia sinensis Schneid. is steamed or boiled in an autoclave and subsequently cut in round slices. Water is added thereto and the slices are boiled and, as necessary, pressed. Crude fiber ingredients are filtered to provide a liquid extract, which is then directly used as toilet water or prepared to afford a cosmetic, such as toilet water, cream or lotion. The fruit of the Pseudocydonia sinensis Schneid. contains mush pectin and amino acid nitrogen in parts near the flower center and the perianth and flower center are rich in the pectin and further contain malic acid, citric acid, saponin, etc. Since the extract is a smooth opaque pink substance having tackiness and contains much gums, the softness of the skin can be maintained therewith.
Inflammation is affected by topical application of a boron containing compound/complex in which a central tetrahedral boron atom is covalently bound to four ligands. At least one of the ligands preferably includes an oxygen, nitrogen, carbon, or sulfur atom, and preferably all four ligands include at least one such atom. Preferred ligands are saccharides and amino acids, including fructose, sorbitol, mannitol, xylitol, sorbose, serine and threonine. Especially preferred ligands have a conformation with at least two hydroxyl groups, or one hydroxyl group and one amino group in a 1,2- and a 1,3-position relative to each other, providing a high association constant in the range of about 3,000 and about 20,000. The compounds/complexes are preferably provided in formulations which provide good transdermal delivery, including appropriate solvent systems, microemulsions, liposomes. Particularly targeted inflammations are those of the joints and skin, including bums such as sunburn.
Post-operative pain control is a common concern patients have when they consider undergoing a surgical procedure. Although effective for treating acute pain, opioid analgesics are also associated with dose-dependent adverse effects, including constipation, nausea and vomiting, altered mental status, and respiratory depression, all of which have been shown to increase patient length of stay. The use of non-opioid analgesics with different mechanisms of actions for acute pain control via a multi-modal approach is efficacious in reducing opioid consumption, decreasing the incidence of adverse effects, improving patient satisfaction and recovery time, and decreasing hospital costs.Certain minimally invasive procedures may afford many patients the opportunity to achieve adequate post-operative pain control with minimal to no requirement of opioid analgesics, thereby sparing the patient known adverse effects that can increase length of stay and costs. The ENTS approach for resection of pituitary tumors is the standard surgical procedure for these lesions, and is associated with pain that is more easily managed post-operatively, making it an ideal procedure for an opioid-sparing post-operative pain regimen. Anecdotally, the investigators note that in the investigator's post-operative pituitary patient population that post-operative pain can frequently be adequately managed with scheduled non-opioid analgesics, often without requiring breakthrough opioid doses. Another safe and effective non-opioid analgesic that is widely used in multi-modal pain management for moderate pain is IV Caldolor (ibuprofen). After literature review, the investigators were unable to find a study that had attempted to use an opioid-sparing analgesic regimen for post-operative pain control following ENTS approach for resection of pituitary tumors.
PURPOSE:A soft capsule containing hydrophilic substance of high stability that is produced by dispersing a clathrate formed from a hydrophilic substance and a clathrate compound in an oil and allowing the resultant dispersion to be contained. CONSTITUTION:A hydrophilic substance such as raw royal jelly, herb extract is mixed with a clathrate compound such as beta-cyclodextrin to form a clathrate. Then, the clathrate is dispersed in an oil to form a stable dispersion containing a hydrophilic substance, then soft capsules are filled with the dispersion to give the objective soft capsules. As the oil, is preferably an ester of a medium-sized chain fatty acid of 8-10 carbon atoms, further preferably containing more than 10wt% of hardened oil. The content of the clathrate in the soft capsule is lower than 50wt%. Thus, the capsulation of a hydrophilic substance becomes possible. The clathrate also is remarkably improved in its stability by capsulation.
PURPOSE:To provide a new human tooth precementum derived cell growth factor(PCDGF) and to treat and prevent periodontosis such as pyorrhea alveolaris, etc. CONSTITUTION:A human tooth precementum derived cell growth factor(PCDGF) having the following properties. (1) Molecular weight (by gel filtration method): 75,000+ or -5,000. (2) Isoelectric point (6.5+ or -1.0). (3) Thermostability: not being deactivated by heat treatment at 60 deg.C for 30 minutes. (4) Stability to enzyme: being deactivated by protease treatment. (5) Physiological action: having chemoattractive rotency on gingiva fibroblast. The human tooth precementum derived cell growth factor is produced by immersing human tooth precementum in sodium chloride injection while stirring while stirring and collecting the human tooth precementum derived cell growth factor from a sodium chloride injection fraction by molecular weight fractionation operation.
Prognosis for patients with esophageal squamous cell carcinoma (ESCC) remains poor. Surgery is one of the standard treatments for patients with ESCC who are considered to have a curative resection, however, approximately 40% of patients develop tumor recurrence within two years after surgery. The main cause of poor prognosis in ESCC patients undergoing surgery is postoperative tumor recurrence due to the presence of latent micro-metastases at the time of surgery. Even with today's advances in preoperative diagnostic techniques, predicting early tumor recurrence remains difficult due to the lack of established methods. Epigenetic markers, especially DNA methylation, are considered ideal markers for predicting cancer metastasis due to their cancer-specific methylation patterns, biological stability, and technical reproducibility. Our study aims to evaluate methylation of surgical specimens to assess residual disease and predict early recurrence.
This group will present to our Level 1 Trauma Center as a trauma patient with no injury to their head. They will be older than age 4, have no major neurologic or psychiatric disorder, be developmentally normal, and will not be prisoners.
OBJECTIVE: This study aimed to investigate the limitations, barriers, and complications in the early transition from the microscopic transsphenoidal approach (MTA) to the endonasal endoscopic approach (EEA) to the skull base in our institution.
METHODS: Technical challenges, as well as clinical features and complications, were compared between MTA, EEA, and mixed cases during the early surgical curve.
RESULTS: The period from the early learning curve was 1 year until the EEA protocol was used routinely. A total of 34 patients registered a resection using a transsphenoidal approach. Eighteen patients underwent EEA, 11 underwent MTA, and five underwent a mixed endonasal and microscopic approach. Non-significant differences were found in endocrine outcomes between the three groups. Patients with unchanged or improved visual function were higher in the EEA group (p = 0.147). Non-significant differences were found in terms of the extent of resection (EOR) between groups (p = 0.369). Only 1 (2.9%) patient in the whole series developed a post-operative CSF leaking that resolved with medical management, belonging to the EEA group (5.5%).
CONCLUSIONS: The early phase of the learning curve did not affect our series significantly in terms of the EOR, endocrine status, and visual outcomes.
Central retinal artery occlusion (CRAO), a type of acute retinal arterial ischemia, analogous to an ocular stroke, is a medical emergency that warrants immediate diagnosis and treatment. CRAO usually presents with sudden, painless, monocular vision loss. Ipsilateral carotid artery disease is an important associated finding in these patients. The primary limitation to effective treatment of CRAO is that patients are rarely seen in the acute stage. Moreover, there are no guidelines for effective treatment. We report a patient with right CRAO whose treatment with intravenous thrombolysis with tenecteplase and anterior chamber paracentesis with ocular massage resulted in a good clinical outcome.
BACKGROUND: Several studies have identified associations between some of circulating inflammatory cytokines and gestational diabetes mellitus (GDM). However, the causal role of these associations remains unclear and unsystematic. We aimed to provide evidence for the causal relationships between circulating inflammatory cytokines and gestational diabetes mellitus.
METHODS: We performed bidirectional two-sample Mendelian randomization (2SMR) to investigate the causal connection between circulating inflammatory cytokines and gestational diabetes mellitus. Publicly accessible data for circulating inflammatory cytokines (8,293 individuals) and gestational diabetes mellitus (123,579 individuals) were obtained from genome-wide association study (GWAS).
RESULTS: Only one causal association was identified between circulating inflammatory cytokines and GDM. The inverse variance weighting (IVW) method showed that macrophage migration inhibitory factor (MIF) increased the risk of GDM (OR 1.162, 95%CI 1.044,1.293). Moreover, two causal associations were detected between GDM and circulating inflammatory cytokines. GDM was negatively correlated with interferon gamma-induced protein 10 (IP10) (Beta -0.129, 95%CI -0.236,-0.231) and interleukin-18 (IL18) (Beta -0.133, 95%CI -0.241,-0.026).
CONCLUSION: Mendelian randomization study revealed MIF as a risk factor for gestational diabetes mellitus. This finding offers a new and valuable insight into the pathophysiological mechanisms underlying GDM.
Despite the evolution in tools and techniques, perforation is still one of the most pernicious adverse events of therapeutic endoscopy with potentially huge consequences. As advanced endoscopic resection techniques are worldwide spreading, endoscopists must be ready to manage intraprocedural perforations. In fact, immediate endoscopic closure through a prompt diagnosis represents the first-line option, saving patients from surgery, long hospitalizations and worse outcomes. Traditional and novel endoscopic closure modalities, including clips, suturing devices, stents and vacuum therapy, are increasingly expanding the therapeutic armamentarium for closing these defects. Nevertheless, available literature on this topic is currently limited. In this review our goal is to give an overview on the management of perforations occurring during endoscopic resections, with particular attention to characteristics, advantages, disadvantages and new horizons of endoscopic closure tools.
PURPOSE: To enable a liquid composition for atomization of a ultrasonic atomizer to be used for humidity adjustment and aromatization or deodorization in a residence room or a car interior, or for illness treatment and prophylactic by adding perfume to the liquid composition to prepare an aqueous solution or a suspension. CONSTITUTION: This ultrasonic atomizer is composed of a liquid aspiration end 21 which is immersed in a liquid composition 10 charged in a liquid storage tank 5 as a liquid supply source, and an atomization end 22 provided at a position in which the atomization end 22 comes into contact with a vibration plate 2. The aspiration end is held in a liquid guidance member 20 consisting of a bundle of hollow elements 23 and a hundle holding member 24 for holding the bundle of hollow elements 23. In addition, the vibration plate 2 is caused to vibrate by exciting a piezoelectric vibrator 1 by an electric field given by a power supply part 6, then thereby, the liquid composition 10 aspirated into the atomization end 22, is uniformly changed to fine particles and is discharged as mist. An aqueous solution or a suspension containing perfume is used, and the perfume content is 0.01 to 70wt.%.  Further, the liquid composition may contain a disinfectant.
A single dose of bulk WT1 TCR-transduced T cells (≤ 2 x 107/kg) will be intravenously (i.v.) administered following protocol-specified lymphodepletive conditioning regimen. Additionally, daily IL-2 subcutaneous injections (1x106 units/m2 subcutaneously (s.c.)) will be administered for 5 days concomitantly to each subject, following infusion of the ATIMP.
Corplex Donepezil TDS 5 mg/day with heat. Two skin sensors will be placed underneath the TDS and adjacent to the TDS.
This group is 40-85 years old and has no significant neurological or psychiatric disease. Listening effort testing (with pupillometry) and cognitive testing will be administered for this group - and after a 6-week period of hearing aid use, these measures will be re-tested.
INTRODUCTION: Levodopa-induced dyskinesia (LID) is a debilitating motor feature in a subset of patients with Parkinson's disease (PD) after prolonged therapeutic administration of levodopa. Preliminary animal and human studies are suggestive of a key role of dopamine type 3 (D3) receptor polymorphism (Ser9Gly; rs6280) in LID. Its contribution to development of LID among Indian PD patients has remained relatively unexplored and merits further investigation.
METHODS AND MATERIALS: 200 well-characterised PD patients (100 without LID and 100 with LID) and 100 age-matched healthy controls were recruited from the outpatient department of Institute of Neurosciences Kolkata. MDS-UPDRS (Unified Parkinson's Disease Rating Scale from International Movement Disorder Society) Part III and AIMS (abnormal involuntary movement scale) were performed for estimation of severity of motor features and LID respectively in the ON state of the disease. Participants were analysed for the presence of Ser9Gly single nucleotide variant (SNV) (rs6280) by polymerase chain reaction followed by restriction fragment length polymorphism techniques.
RESULTS: The frequency of AA genotype (serine type) was more frequently present in PD patients with LID compared to PD patients without LID (50 % vs 28 %; P = 0.002; OR = 2.57, 95 % CI: 1.43 - 4.62). The abnormal involuntary movement scale score was significantly higher in PD patients with AA genotype compared to carriers of glycine allele (AG + GG) (4.08 ± 3.35; P = 0.002).
CONCLUSION: We observed a significant association of serine type SNV (rs6280) in D3 receptor gene in a cohort of PD patients with LID from India. More severe motor severity was found in patients with glycine substitution of the same SNV. The current study emphasised the role of D3 receptor in the pathogenesis of LID.
Study subject will topically apply placebo lotion (20-40 drops) 2-4 times daily to the painful area for the next two weeks. The dose titration will be based on the size of painful area (approximately 10 drops for every 4 square inches). Subjects will be asked to fill in a daily pain diary and report any side effects to the research center. A phone number and a beeper number will be provided to subjects.