anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a natural composition for preventing and treating Parkinson's disease, and more specifically, to a natural composition that enhances a motor improvement function in Parkinson's disease, formed of a composition obtained by mixing and extracting Uncaria rhynchophylla, Paeonia japonica, Panax ginseng, Magnolia officinalis Rehd. et Wils. Glycyrrhiza uralensis, Piper nigrum, and Spatholobus suberectus Dunn. The present invention provides a natural composition that enhances a motor improvement function in Parkinson's disease, formed of a composition obtained by mixing and extracting Uncaria rhynchophylla, Paeonia japonica, Panax ginseng, Magnolia officinalis Rehd. et Wils. Glycyrrhiza uralensis, Piper nigrum, and Spatholobus suberectus Dunn. In addition, the present invention provides a natural composition that enhances a motion improvement function in Parkinson's disease, formed by including any one or more of Chrysanthemum indicum, Phellodendron amurense Rupr and Dioscorea batatas and extracting the same. Furthermore, the present invention provides a pharmaceutical composition having a motor improvement function in Parkinson's disease, comprising the natural composition that enhances a motor improvement function in Parkinson's disease.
FIELD: medicine, chemical-pharmaceutical industry, pharmacy. SUBSTANCE: invention relates to the development of agents used in common cold for curative-prophylactic aims. The proposed agent comprises dry extracts of purple coneflower, Saint-John's-wort, wild rose and licorice root and also nutrient citric acid and special supplements. An agent can be made as syrup or granules. Testing the proposed agent in spring-autumn period showed good clinical results. Also the use of this agent is suitable in the proposed medicinal form. EFFECT: valuable medicinal properties of agent. 5 cl, 2 ex
Despite significant therapeutic advancements, morbidity and mortality following myocardial infarction (MI) remain unacceptably high. This clinical challenge is primarily attributed to two significant factors: delayed reperfusion and the myocardial injury resulting from coronary reperfusion. Following reperfusion, there is a rapid intracellular pH shift, disruption of ionic balance, heightened oxidative stress, increased activity of proteolytic enzymes, initiation of inflammatory responses, and activation of several cell death pathways, encompassing apoptosis, necroptosis, and pyroptosis. The inflammatory cell death or pyroptosis encompasses the activation of the intracellular multiprotein complex known as the NLRP3 inflammasome. High-density lipoproteins (HDL) are endogenous particles whose components can either promote or mitigate the activation of the NLRP3 inflammasome. In this comprehensive review, we explore the role of inflammasome activation in the context of MI and provide a detailed analysis of how HDL can modulate this process.
One of the main concerns about using packing is that the removal is usually very painful and can be very bothersome. This procedure may even result in syncope by the activation of the vasovagal reflex system. There have been a few studies suggesting that nasal packs should not be used because removal from the nose causes serious discomfort and is painful. Many patients who have undergone nasal surgery report that the removal of the pack was the most painful part of the experience.

Postoperative pain is an acute inflammatory pain that starts with surgical trauma and ends with tissue healing. It can be harmful to organ systems by initiating inflamma¬tion through different mechanisms, and the alleviation of postoperative pain is considered important for obtaining homeostasis. Pain may initiate atelectasis due to improper coughing, immobilization may cause thromboembolism and catecholamine discharge may induce cardiovascular side effects and undesired changes in neuroendocrine or meta¬bolic function
The present invention relates to an animal and plant high-efficiency ecological nutrient solution and a preparation method thereof. The nutrient solution is prepared from compound amino acids, a perilla extracted solution, alizarin powder, titanium tetrachloride, manganese sulfate, copper sulfate, orthoboric acid, gluconic acid, potassium dihydrogenphosphate, ferrous sulfate, organic acid calcium, nicotinamide, yeast, cobalt carbonate, strontium chloride, sodium selenite, chitin, nucleic acid, ammonium molybdate, grape pip powder, protein jelly and water to form an organic titanium complex through industrial fermentation and a complex reaction. The plant high-efficiency ecological nutrient solution suitable for various crops has the advantages of high crop broad spectrum property, high utilization rate, quick effect obtainment, persistent fertilizer effects, soil improvement, cost reduction, obvious quality improvement, obvious yield increase and obvious pollution reduction. The plant high-efficiency ecological nutrient solution can reduce more than 50% of the nitrate content. The animal and plant high-efficiency ecological nutrient solution for cultivation industry has the advantages of sufficient fodder nutrient component increase and supplement, no harmful substance residual, obvious production quantity increase, fresh and tender meat quality, and good meat mouth feel. The animal and plant high-efficiency ecological nutrient solution reduces the death rate of animals 50 to 60%.
PURPOSE:To provide the titled activation agent containing a reduced product of a branched oligosaccharide having alpha-1,6-bond of glucose molecule. CONSTITUTION:The objective growth activation agent for bifidus bacterium can be produced by compounding (A) 70-30pts. (solid basis) of a reduced product of a branched oligosaccharide having alpha-1,6-bond of glucose molecule (e.g. isomaltitol, panitol, isomaltotritol, isomaltotetritol, etc.) with (B) 30-70pts. of bifidus bacterium (dried cell, etc., of bacterial strain belonging to Bifidobacterium genus) and (C) a vitamin essential for the growth of bifidus bacterium (e.g. pantethine). The alcohol of branched oligosaccharide is produced by hydrogenating the corresponding branched oligosaccharide at 50-150 deg.C in the presence of a reduction catalyst such as Raney-nickel. A remarkably effect in the proliferation of bifidus bacterium can be attained by adding 1/100-1/300pts. of the above vitamin based on 1pt. of the branched oligosaccharide alcohol.
In this study we explored the relationship between home birth rates and increasing rates of postpartum haemorrhage (PPH) and manual removal of the placenta (MROP). Data were used from the Dutch national perinatal registry (2000-2014) of women in midwife-led care. Adjusting for place of birth flattened the increasing trends of PPH and MROP. By adjusting for place of birth, the rising trend of MROP among multiparous women disappeared. This suggests that if home birth rates had not declined, PPH and MROP rates might not have increased as much. This study supports policies of enabling women to choose home births.
The invention discloses a 4-(2-methylacryloyl)-7-oxo-1,4-high-hydrogen oxazepine, a preparation method and applications thereof. The preparation method provided by the invention adopts piperidone hydrochloride as a raw material, and the 4-(2-methylacryloyl)-7-oxo-1,4-high-hydrogen oxazepine is prepared by acidating and selectively oxidating the piperidone hydrochloride. The 4-(2-methylacryloyl)-7-oxo-1,4-high-hydrogen oxazepine is a novel high-hydrogen oxazepine monomer which contains functional side groups. Aliphatic polyester, which is multi-functional and has good biocompatibility and biodegradability, is synthesized by ring-opening polymerization of the high-hydrogen oxazepine monomer. Various drug molecules, some active molecules, and high polymer materials which are sensitive to acid or heat can be inputted into functional groups of the side groups. Therefore, the 4-(2-methylacryloyl)-7-oxo-1,4-high-hydrogen oxazepine of the invention has broad applications in high polymer targeted drugs and tissue engineering.
Prolonged action medicament contains an association of theophylline (1,3-dimethyl-xanthine) or its derivs. and a cinnamamide of formula (I) or 4-R-Ph-CH=CH-CO-NR1R2 (I) (where R is H, halo or acetyl; R1 is H or methyl; R2 is CHR3-CH2OH; R3 is H or methyl or R1 and R2 together with the N atom are 2,2-dimethyl-3-oxazolidinyl). Cinnamamides of formula (I) are new where a) R is H or halo and -NR1R2 is 2,2-dimethyl-3-oxazolidinyl and b) R is acetyl, R1 is H and R2 is hydroxyethyl. Theophylline is a known bronchodilator used in the treatment of asthma, but is not well tolerated and not very effective. To give best results it would have to be administered every 6 hrs. The association of theophylline with (I) gives prolonged activity (up to 24 hrs.) and may be administered orally, parenterally or rectally. Activity tests are described.
BACKGROUND: Striae distensae is a disfiguring atrophic skin condition that impairs the body's aesthetic image. Despite the variety of conducted studies, there is controversy regarding the best modalities. Human mesenchymal stem cells are considered a rich source for scar treatment. Skin needling is among the most efficient and safe aesthetic and therapeutic devices. This study aimed to evaluate the efficacy of the combination of needling and intradermal injection of mesenchymal stem cells compared to skin needling alone for treating striae distensae.
METHOD: This study was a randomized, double-blind clinical trial involving 10 women aged 18-60. Each striae lesion was divided into two parts, with one side receiving needling and intradermal injection of conditioned medium, while the other side received needling and intradermal injection of normal saline. This treatment was administered in three sessions with three-week intervals. Patients were evaluated before the first intervention and three months after the final session. Three months after the completion of the intervention, patients' lesions were evaluated using biometric criteria, physician evaluation, and patient self-assessment.
RESULTS: The results demonstrated a significant improvement in dermal and complete thickness and skin density in patients treated with microneedling. All skin ultrasound parameters improved significantly in patients receiving the combination of needling and conditioned medium. When comparing the two groups, significantly higher physician and patient satisfaction was observed in the combination group. However, the comparison of biometric indices improvement wasn't significant between these groups.
CONCLUSION: The combination of human mesenchymal stem cells with microneedling could be considered a novel effective option for stretch marks.
BACKGROUND RARP is an established procedure in treatment of localized prostate cancer. Hemorrhagic complications in the postoperative period are rare, but sometimes life-threatening. Adequate monitoring and prompt intervention in these unusual scenarios rely on clinical judgement and blood and imaging studies. Prostatic fossa pseudoaneurysm formation after RARP is very rare and its etiology is not well known; it may be related to small vessel trauma. It becomes apparent with the development of hematuria 1-6 weeks after surgery. CASE REPORT A 58-year-old man underwent RARP with extended lymph node dissection for intermediate-risk prostate cancer, with bilateral preservation of neurovascular bundles and puboprostatic ligaments. He was discharged on day 2 without complications. In the following 4 weeks he came to the Emergency Department 3 times with hematuria and acute urinary retention. Four weeks after surgery, a pelvic CT angiogram showed a 20-mm pseudoaneurysm in the prostatic fossa, which was embolized by percutaneous angiography, with resolution of symptoms. He was discharged soon thereafter. CONCLUSIONS This case study describes a patient with prostatic fossa pseudoaneurysm after RARP. It was diagnosed 1 month after surgery and effectively managed by percutaneous embolization. Despite being a very rare condition, it must be kept in mind, especially when postoperative hematuria develops 1-6 weeks after surgery. Use of a management algorithm including serial blood tests, CT angiogram, and percutaneous angiography can lead to early detection and avoid life-threatening hemorrhage and overall postoperative morbidity.
For participants in the waiting list control group, they will receive monitoring service over phone calls during the 8-12 weeks wait period. Counselling service will be offered after the post-treatment assessment.
Liquiritigenin (LQ) is a monomeric compound found in licorice, a leguminous plant, and has been reported to exhibit antitumor effects in various lines of cancer cells. However, the underlying molecular mechanisms by which LQ exerts its antitumor effects remain largely unknown. In this study, the effects of LQ on the migration, invasion, and epithelial-mesenchymal transition (EMT) of prostate cancer (PCa) cells were investigated. We found that LQ effectively inhibited the migration and invasion of PCa cells in vitro, and this effect was further confirmed in xenograft lung metastasis models. In addition, LQ was found to activate endoplasmic reticulum stress (ER stress) in PCa cells. Further studies found that LQ upregulated the expression of inositol-requiring enzyme type 1α (IRE1). When IRE1 was knocked down, we observed a weakened inhibitory effect of LQ treatment on the migration and invasion of PCa cells. This observation suggests that LQ may inhibit the migration, invasion and EMT of PCa cells through activating the IRE1 branch of ER stress. In conclusion, our research may provide a novel therapeutic strategy for PCa.
PURPOSE:To obtain the titled material having excellent affinity to gingival tissue and appearance and the free from toxicity to human body, by adding a metal oxide as a coloring component, a metal component as a coloring assistant component and optionally Al2O3 and/or SiO2 as coloring adjuvant to a calcium phosphate composition having a specific Ca/P atomic ratio. CONSTITUTION:(A) 100pts.wt. of a calcium phosphate material produced by mixing a Ca-containing compound such as CaO, CaCO3, etc., with a P-containing compound such as orthophosphoric acid, polyphosphoric acid, etc., at a ratio to give a Ca/P atomic ratio of 0.35-1.7 is compounded with (B) 0.01-5pts.wt. of one or more coloring components selected from oxides of Zn, Fe, Mn, Ce, W, Ti, Ni, Co, Cr or V, (C) 0.1-5pts.wt. (in terms of metal) of a coloring assistant component consisting of a component containing one or more metals selected from Au, Ag and Cu (e.g. auric chloride) and (D) <=10pts.wt. of a optional coloring adjuvant composed of Al2O3 and/or SiO2. The produced mixture is vitrified by melting, molded in the form of desired dental crown, etc., and crystallized to obtain a dental crown, etc., having the color tone of a natural tooth.
Diffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses a significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), with a typical cure rate of 50-70%. However, some patients either relapse after complete remission (CR) or exhibit resistance to R-CHOP treatment. Therefore, novel therapeutic approaches are imperative for managing high-risk or refractory DLBCL. Ferroptosis is driven by iron-dependent phospholipid peroxidation, a process that relies on the transition metal iron, reactive oxygen species (ROS), and phospholipids containing polyunsaturated fatty acids-containing phospholipids (PUFA-PLs). Research indicates that ferroptosis is implicated in various carcinogenic and anticancer pathways. Several hematological disorders exhibit heightened sensitivity to cell death induced by ferroptosis. DLBCL cells, in particular, demonstrate an increased demand for iron and an upregulation in the expression of fatty acid synthase. Additionally, there exists a correlation between ferroptosis-associated genes and the prognosis of DLBCL. Therefore, ferroptosis may be a promising novel target for DLBCL therapy. In this review, we elucidate ferroptosis mechanisms, its role in DLBCL, and the potential therapeutic targets in DLBCL. This review offers novel insights into the application of ferroptosis in treatment strategies for DLBCL.
Regimen A: docetaxel 75 milligrams per square meter (mg/m\^2), intravenous (IV) is administered on Day 1 every 3 weeks for 6 cycles (maximum up to 10 cycles) and prednisone 5 milligrams (mg) oral (po), twice daily (BID) every day. In Cycle 1, enzastaurin is given as a loading dose of 1125 mg on the day prior to docetaxel and prednisone therapy, followed by enzastaurin 500 mg po, daily (QD) for the remaining Period 2 (chemotherapy) and Period 3 (maintenance).
Patients receive ferumoxytol and gadolinium IV and then undergo DSC-MRI and DCE-MRI. An optional MRI without injection of a contrast agent may be obtained after 20-24 hours at the discretion of the clinician. Patients may receive up to 3 more scans at least 3 weeks apart over up to 2 years.
Approximately 1000 subjects with clinical diagnoses of asthma and/or COPD or clinical presentations suggestive of either or both will be included. Subjects will undergo spirometry assessments and also will be asked a series of questions by a qualified health care practitioner using a questionnaire containing 41 questions concerning their respiratory condition.
Diabetic wounds, resulting from skin atrophy due to localized ischemia and hypoxia in diabetic patients, lead to chronic pathological inflammation and delayed healing. Using electrospinning technology, we developed magnesium ion-chelated nanofiber membranes to explore their efficacy in antibacterial, anti-inflammatory, and angiogenic applications for wound healing. These membranes are flexible and elastic, resembling native skin tissue, and possess good hydrophilicity for comfortable wound bed contact. The mechanical properties of nanofiber membranes are enhanced by the chelation of magnesium ions (Mg2+), which also facilitates a long-term slow release of Mg2+. The cytocompatibility of the nanofibrous membranes is influenced by their Mg2+ content: lower levels encourage the proliferation of fibroblasts, endothelial cells, and macrophages, while higher levels are inhibitory. In a diabetic rat model, magnesium ion-chelated nanofibrous membranes effectively reduced early wound inflammation and notably accelerated wound healing. This study highlights the potential of magnesium ion-chelated nanofiber membranes in treating diabetic wounds.
To make it possible to display a series of image data captured according to examination order information, in a predetermined order. According to an image examination device (3) as the medical information processing device, image data received from modality as an image generation device is classified by examination order information according to the examination ID. Examination information contained in the additional information on each image data captured according to the same examination order information is acquired. Each of the acquired examination information is subjected to code conversion according to a display conversion table (361) and the converted codes are sorted in the ascending order. An image examination waiting list number is assigned to each image data in the order corresponding to the sort result and successively added and registered in an image examination waiting image storage section (362). Additional information on the image data stored in the image examination waiting image storage section (362) is arranged in a list according to the image examination waiting list number and the list is displayed on a display section (33).
INTRODUCTION: Fabry's disease (FD) is a genetic X-linked systemic and progressive rare disease characterized by the accumulation of globotriaosylceramide (GB3) into the lysosomes of many tissues. FD is due to loss-of-function mutations of α-galactosidase, a key-enzyme for lysosomal catabolism of glycosphingolipids, which accumulate as glycolipid bodies (GB). In homozygous males the progressive deposition of GB3 into the cells leads to clinical symptoms in CNS, skin, kidney, etc. In testis GB accumulation causes infertility and alterations of spermatogenesis. However, the precise damaging mechanism is still unknown. Our hypothesis is that GB accumulation reduces blood vessel lumen and increases the distance of vessels from both stromal cells and seminiferous parenchyma; this, in turn, impairs oxygen and nutrients diffusion leading to subcellular degradation of seminiferous epithelium and sterility.
METHODS: To test this hypothesis, we have studied a 42-year-old patient presenting a severe FD and infertility, with reduced number of spermatozoa, but preserved sexual activity. Testicular biopsies were analyzed by optical (OM) and transmission electron microscopy (TEM). Activation and cellular localization of HIF-1α and NFκB was analyzed by immunofluorescence (IF) and RT-PCR on homogeneous tissue fractions after laser capture microdissection (LCMD).
RESULTS: OM and TEM showed that GB were abundant in vessel wall cells and in interstitial cells. By contrast, GB were absent in seminiferous epithelium, Sertoli's and Leydig's cells. However, seminiferous tubular epithelium and Sertoli's cells showed reduced diameter, thickening of basement membrane and tunica propria, and swollen or degenerated spermatogonia. IF showed an accumulation of HIF-1α in stromal cells but not in seminiferous tubules. On the contrary, NFκB fluorescence was evident in tubules, but very low in interstitial cells. Finally, RT-PCR analysis on LCMD fractions showed the expression of pro-inflammatory genes connected to the HIF-1α/NFκB inflammatory-like pathway.
CONCLUSION: Our study demonstrates that infertility in FD may be caused by reduced oxygen and nutrients due to GB accumulation in blood vessels cells. Reduced oxygen and nutrients alter HIF-1α/NFκB expression and localization while activating HIF-1α/NFκB driven-inflammation-like response damaging seminiferous tubular epithelium and Sertoli's cells.
Beginning in the spring of 2011, residents in this group will receive an email web-link to complete 4 simulated assessment cases and a diabetes knowledge survey. They will subsequently be sent 3 learning cases a month for 6 months and a satisfaction survey to complete.
The invention relates to a cyclic peptide which not only reduces insulin but also properly reduces blood sugar without increasing blood sugar, belonging to the technical field of biological pharmacy. The bifunctional cyclic peptide is original linear short peptide COX 52‑69 Based on the in vitro modification, two seemingly contradictory effects are realized, namely the effect of inhibiting insulin secretion without increasing blood sugar but reducing blood sugar, and the mechanism of the effect is probably to improve the sensitivity of tissues to insulin. We call bifunctional peptides. The application of the composition can be used for treating congenital insulinemia, insulin resistance and obesityThe literature reports that the increase of insulin is the cause of obesity, but the weight loss cannot be achieved by reducing insulin, because the blood sugar is increased after the insulin is reduced, and the hyperglycemia has more adverse effects on health. The cyclopeptide realizes the function of reducing the blood sugar without increasing the blood sugar while reducing the insulin, opens up a new medicine for treating the obesity, and the medicine can be injected and conveniently taken orally. Greatly improving the convenience of using the medicine.