anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Treatment will consist of a 1+10 module internet delivered CBT program targeting problem gambling, newly developed. A bottom-up procedure was used to develop the treatment protocol, inspired by Clark's (2004) method for developing novel CBT treatments. We developed a clinical model delineating what factors contribute to the persistence of problem gambling behavior, and aligned these with targeted treatment interventions; based on behavioral upon research on the learning and maintenance processes of gambling behavior (Ramnerö et al, in press), theoretical models of gambling and comorbidity (Blaszczynski \& Nower, 2002); as well as qualitative interviews with treatment seeking gamblers with or without comorbidity.
Growth hormone releasing peptides (GHRPs), a family of synthetic analogs modelled from Met-enkephalin, have been found to bind a novel class of specific GHRP receptors in the mammalian heart that are distinct from the pituitary GHRP  receptors involved in GH secretion. CD36, a multifunctional B-type scavenger receptor, has been identified as the unique GHRP binding site in the heart. CD36 mediates the uptake of lipoproteins into a number of cell types and was recognized to play a crucial role in scavenging oxidized low density lipoproteins in monocyte/ macrophages leading to foam cell formation, a key step in fatty streaks formation.     The hexapeptide GHRP prototypes hexarelin (His - DMe - Trp - Ala - Trp - D Phe - Lys - NH2) and EP 80317 (Haic-D Me - Trp -D Lys - Trp - D Phe- Lys -NH2), the latter analog being devoid of GH-secreting activity in vivo, have been shown to reduce fatty streak lesions and hypercholesterolemia in apolipoprotein E (Apo E) null mice fed a high fat high cholesterol diet (HFHC). In addition, non-HDL cholesterol was significantly decreased, whereas HDL cholesterol tended to increase. GHRP treatment also inhibited oxLDL-induced monocyte chemotaxis in the peritoneal cavity, which was associated with a reduced expression of the CD36 protein on peritoneal monocytes/macrophages.  GHRPs may represent a novel therapeutic avenue to reduce the severe morbidity associated with the arterial disease atherosclerosis and its complications, such as myocardial infarction and strokes, that occur despite current management strategies.
A metric analysis and comparative efficacy research will be conducted. Eighty-four pre-frail elderly will receive dual-task walking assessments twice at pretreatment with a 1-week interval for test-retest assessment and investigation of the reliability and validity of outcome measures. The primary outcome measure of the dual-task walking assessments will include walking at preferred speed and fast speed and simultaneously perform serial three subtractions and the Stroop task. Concurrent validity will be studied to validate the dual-task walking measures with each other and with the item 14 of the mini-Balance Evaluation Systems test (Mini-BESTest), dual-task Timed-up-and-Go test (dual-TUG), and 6-min walk test obtain concurrently for assessing dual-task ability. A comparative efficacy research is a single-blind, randomized controlled trial, which will be conducted at medical centers. Pre-frail elderly will be randomized to combined motor and cognitive training, motor training alone, cognitive training alone, or no intervention control group. All three training groups will receive interventions 3 times a week for 4 weeks. The combined motor and cognitive training group will undertake physical fitness training under sitting and standing, walking training while sequentially or simultaneously perform cognitive training. The motor training alone group will train the same set of physical fitness training while sitting, standing, and walking as the combined motor and cognitive training group. The cognitive training alone group will train the same set of cognitive training while sitting as the combined motor and cognitive training group. No intervention control group will maintain habit and daily activity. A blinded assessor will administer three assessments. All participants will be examined physical fitness and brain fitness at baseline twice, and post intervention. The primary outcome measures will be components of physical fitness (cardiopulmonary fitness, muscle fitness, flexibility, body composition, and balance)and brain fitness (information processing speed, working memory, response inhibition, spatial memory, and selective attention). The secondary outcome measures will be gait and cognitive performance under dual-task conditions, dual-Timed Up and Go test, the Mini-BESTest, Functional Gait Assessment, and 6-minute Walk Test, Repeated measure ANOVA will be used to compare measurements at baseline and after training among the groups.
Foam quality and discharge properties are improved by using a squeeze container to discharge a mixed solution of first and second agents of a two-part hair cosmetic for hair dyeing or bleaching in a foam. A two-part hair cosmetic 1 for hair dyeing or bleaching includes a first agent A1 containing an alkaline agent and a second agent A2 containing hydrogen peroxide and a squeeze container 6 for discharging a mixed solution A3 of the first agent A1 and the second agent A2. The first agent A1 or second agent A2 contains a foaming agent. The mixed solution A3 thereof has a viscosity (25°C) of from 1 mPa·s to 100 mPa·s. A squeeze foamer 5 of the squeeze container 6 has a gas-liquid mixing chamber 12 for causing the mixed solution to foam, foam homogenizing means 14 for homogenizing foam of the mixed solution which has been made to foam in the gas-liquid mixing chamber 12, and a discharge outlet 17 for discharging the homogenized foam. The ratio between the total volume of the first and second agents and the inner volume of the container body is in the range of from 0.30 to 0.60. The torso cross-section of the container body has a ratio of minor axis to major axis of from 0.5 to 1.0, and an area of from 12 cm 2  to 30 cm 2 .
The intervention comprises 1) GP counseling, 2) 3-minute promotional video on mammography and 3) an informational brochure with relevant contact details and information for arranging a mammography screening. Pre- and post-consultation questionnaire were administered to participants to evaluate their health beliefs, with emphasis on breast cancer and mammography.
Circadian rhythm disruption is increasingly considered an environmental risk factor for the development and exacerbation of inflammatory bowel disease. We have reported in a previous study that nychthemeral dysregulation is associated with an increase in intestinal barrier permeability and inflammation in mice with dextran sulfate sodium (DSS)-induced colitis. To investigate the effect of circadian rhythm disruption on the composition and diversity of the gut microbiota (GM), sixty male C57BL/6J mice were initially divided to two groups, with the shifted group (n = 30) exposed to circadian shifts for three months and the non-shifted group (n = 30) kept under a normal light-dark cycle. The mice of the shifted group were cyclically housed for five days under the normal 12:12 h light-dark cycle, followed by another five days under a reversed light-dark cycle. At the end of the three months, a colitis was induced by 2% DSS given in the drinking water of 30 mice. Animals were then divided into four groups (n = 15 per group): sham group non-shifted (Sham-NS), sham group shifted (Sham-S), DSS non-shifted (DSS-NS) and DSS shifted (DSS-S). Fecal samples were collected from rectal content to investigate changes in GM composition via DNA extraction, followed by high-throughput sequencing of the bacterial 16S rRNA gene. The mouse GM was dominated by three phyla: Firmicutes, Bacteroidetes and Actinobacteria. The Firmicutes/Bacteroidetes ratio decreased in mice with induced colitis. The richness and diversity of the GM were reduced in the colitis group, especially in the group with inverted circadian rhythm. Moreover, the GM composition was modified in the inverted circadian rhythm group, with an increase in Alloprevotella, Turicibacter, Bacteroides and Streptococcus genera. Circadian rhythm inversion exacerbates GM dysbiosis to a less rich and diversified extent in a DSS-induced colitis model. These findings show possible interplay between circadian rhythm disruption, GM dynamics and colitis pathogenesis.
Farnesoid X receptor (FXR) plays a key role in bile acid homeostasis, inflammation, fibrosis, lipid and glucose metabolism and is emerging as a promising therapeutic target for nonalcoholic steatohepatitis (NASH). Emerging evidence suggested that intestine-specific FXR antagonists exhibited remarkable metabolic improvements and slowed NASH progression. In this study, we discovered several potent FXR antagonists using a multistage ligand- and structure-based virtual screening approach. Notably, compound V023-9340, which possesses a 4-aminophenylacetamide scaffold, emerged as the most potent FXR antagonist with an IC50 value of 4.27 μM. In vivo, V023-9340 demonstrated selective accumulation in the intestine, substantially ameliorating high-fat diet (HFD)-induced NASH in mice by mitigating hepatic steatosis and inflammation. Mechanistic studies revealed that V023-9340 strongly inhibited intestinal FXR while concurrently feedback-activated hepatic FXR. Further structure-activity relationship optimization employing V023-9340 has resulted in the synthesis of a more efficacious compound V02-8 with an IC50 value of 0.89 μM, which exhibited a 4.8-fold increase in FXR antagonistic activity compared to V023-9340. In summary, 4-aminophenylacetamide derivative V023-9340 represented a novel intestine-specific FXR antagonist and showed improved effects against HFD-induced NASH in mice, which may serve as a promising lead in discovering potential therapeutic drugs for NASH treatment.
The invention discloses anti-fatigue perfect healthcare wine. The anti-fatigue perfect healthcare wine comprises, by weight, 5-15 parts of Chinese yam, 5-15 parts of polygonatum odoratum, 2-8 parts of licorice, 3-17 parts of longan pulp, 3-17 parts of cinnamon, 2-8 parts of poria cocos, 2-9 parts of alpinia oxyphylla, 5-15 parts of polygonatum kingianum, 3-17 parts of barbary wolfberry fruits, 2-9 parts of semen ziziphi spinosae and 2370-4150L of white spirit. A method for making the anti-fatigue perfect healthcare wine includes adding the 50%vol white spirit into raw materials when the anti-fatigue perfect healthcare wine is about to be made; extracting the reflux thrice at the temperatures of 75+/-3 DEG C; combining extracted liquid obtained in three procedures; centrifuging the extracted liquid and carrying out micro-filtration on the extracted liquid by ceramic films; adding pure water and white granulated sugar into the extracted liquid to blend the extracted liquid, clearing the extracted liquid, ageing the extracted liquid for 150 days, then filtering the extracted liquid until the extracted liquid is clear and transparent to obtain the anti-fatigue perfect healthcare wine. The volumes of the 50%vol white spirit added into the raw materials in the three procedures are 10 times, 8 times and 6 times the weights of medicinal materials respectively. The reflux is extracted for 2 hours in each procedure. The anti-fatigue perfect healthcare wine and the method have the advantages that the healthcare wine is light brownish red, clear and transparent, has harmonious and elegant composite medicinal aroma and wine aroma, tastes mellow, has harmonious medicinal flavor and typical styles, is safe and non-toxic and has anti-fatigue healthcare functions.
Grapevine downy mildew, caused by the oomycete Plasmopara viticola (P. viticola, Berk. & M. A. Curtis; Berl. & De Toni), is a global threat to Eurasian wine grapes Vitis vinifera. Although resistant grapevine varieties are becoming more accessible, P. viticola populations are rapidly evolving to overcome these resistances. We aimed to uncover avirulence genes related to Rpv3.1-mediated grapevine resistance. We sequenced the genomes and characterized the development of 136 P. viticola strains on resistant and sensitive grapevine cultivars. A genome-wide association study was conducted to identify genomic variations associated with resistant-breaking phenotypes. We identified a genomic region associated with the breakdown of Rpv3.1 grapevine resistance (avrRpv3.1 locus). A diploid-aware reassembly of the P. viticola INRA-Pv221 genome revealed structural variations in this locus, including a 30 kbp deletion. Virulent P. viticola strains displayed multiple deletions on both haplotypes at the avrRpv3.1 locus. These deletions involve two paralog genes coding for proteins with 800-900 amino acids and signal peptides. These proteins exhibited a structure featuring LWY-fold structural modules, common among oomycete effectors. When transiently expressed, these proteins induced cell death in grapevines carrying Rpv3.1 resistance, confirming their avirulence nature. This discovery sheds light on the genetic mechanisms enabling P. viticola to adapt to grapevine resistance, laying a foundation for developing strategies to manage this destructive crop pathogen.
Among the causes of chest pain, slipping rib has a low prevalence, usually with a history of trauma, and its management is controversial. Slipping rib syndrome should be included in the differential diagnosis of causes of chest pain in children. When not associated with previous trauma and cartilage deformity, it is necessary to consider an alteration in rib development, regardless of the typical traumatic etiology in adults. Here we describe a series of pediatric patients with slipping rib seen at a referral hospital between 2001 and 2022. Nine patients aged 11 to 16 years were included. Only 2 had a history of trauma. All patients described a sudden onset of severe thoracic abdominal pain. The patients underwent open resection of the affected costal cartilages, with resolution of pain.
Home exercise program Children will be given a home program including stretching, breathing, normal joint movement, body weight and mildly resistant exercises, and children will be asked to do these for 3 to 5 days a week. Also, aerobic training will be performed 3 days a week for 12 weeks at 60% of their maximum hearth rate with 50 minutes total duration consisting of 10 min warm up and 10 min cool down period to children in treatment group.
Promethazine hydrochloride tablets, USP may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. The use of alcohol or other central- nervous-system depressants such as sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers, may enhance impairment (see Error! Hyperlink reference not valid. and PRECAUTIONS - Drug Interactions). Pediatric patients should be supervised to avoid potential harm in bike riding or in other hazardous activities.

Patients should be advised to report any involuntary muscle movements.

Avoid prolonged exposure to the sun.
The invention discloses a diamond algae strain for accumulating palmitoleic acid in high yield and application thereof. The preservation number of the diamond algae (Nitzschiasp.) Y3 is CCTCCM2023030Y3, and the preservation address is: eight paths of 299 Wuhan university in Wuhan district of Wuhan, hubei province; the diamond algae (Nitzschiasp.) Y3 is observed under a microscope to be in a single cell structure, the cells are in a spindle shape, two ends of the diamond algae are in a symmetrical structure, the length is 24-31 mu m, the width is 6-7 mu m, and the cells proliferate in a longitudinal division mode. The diamond algae (Nitzschiasp.) Y3 has simple and reasonable fatty acid composition, and can be used for producing high-quality biodiesel; the palmitoleic acid can account for 60-70% of total fatty acid, is favorable for extraction and purification of palmitoleic acid, and can be used for producing healthcare products, foods, medicines and the like related to palmitoleic acid; can be cultivated by utilizing pickling wastewater, salt lake or sea water, has better temperature and pH adaptability, can be simply and economically cultivated for producing palmitoleic acid, and is beneficial to reducing the production cost.
Participants will complete measures at baseline and then randomly allocated to receive the intervention or usual care. The intervention group will receive a group psychoeducational intervention (designed in Phase 1: Qualitative study) in addition to self-help leaflets and usual care. It is anticipated that the intervention will be offered in 6 two-hour sessions over 3 months by an assistant psychologist. The control group will receive usual care plus self-help leaflets on relevant topics. All participants will complete outcome measures at 3 and 6 months after randomisation. We will test the feasibility, tolerability and acceptability of delivering the intervention and will record data on study completion and attrition. Findings will inform the development of a larger trial and will determine if the content and delivery of the intervention meets the needs of people after TIA and minor stroke.
The students included in the experimental group 1 practiced the head bathing skill on a model with low proximity to reality. The model used here is a human model belonging to the Gaumard Scientific company with low proximity to reality.
<PICT:0951791/C1/1> In a method of enrichment of ammonia in deuterium by a dual-temperature isotopic exchange between liquid ammonia and a gaseous phase comprising hydrogen (e.g. hydrogen or ammonia synthesis gas), in which the gaseous phase is saturated by direct contact in a scparate exchanger with the vapour of the liquid phase which contains a non-volatile alkali metal amide as a catalyst of the isotopic exchange, liquid ammonia containing catalyst circulating in a closed circuit to make up the quantity of ammonia removed in the saturated gaseous phase, the accumulation of non-volatile dissolve catalyst is avoided by introducing into the circuit a make-up quantity of liquid ammonia containing catalyst, said quantity being equal to the quantity necessary for saturation of the gaseous phase plus a quantity which is at least adequate to allow, by withdrawal of the liquid having the most catalyst, at a point of the circuit located adjacent to the outlet of the separate exchange, the removal of a quantity of catalyst which is at least equal to the quantity which has been introduced with the make-up liquid.  In Fig. 2, ammonia leaves cold tower F and enters hot tower 1 via 3, and travels via 4 and 5 to tower 2 which is the separate exchanger for saturating the gaseous phase.  The gaseous phase enter tower 2 via 6 and trowels via 7 to hot tower 1 and then via 9, heat exchanger 10, and 11 to the cold tower F.  A closed circuit of liquid ammonia containing catalyst comprises tube 15, tower 2, tube 12, heat exchanger 10, tube 13, and reheater 14.  In tower 2 part of the ammonia is removed in the gaseous phase. The circulating ammonia is supplemented by that leaving hot tower 1 via tube 5, and a conduit 16 in tube 12 is used to drain off ammonia which is more concentrated in catalyst than that entering tower 2. Thus the build-up of catalyst in the circulating ammonia is avoided.
The mechanics of bile flow in the biliary system plays an important role in studying bile stasis and gallstone formation. Bile duct stricture is an abnormal phenomenon that refers to the bile duct getting smaller or narrower. The main objective of this study is to study the influence of stricture on bile flow dynamics using numerical methods. We employed a numerical Computational Fluid Dynamics model of the bile flow within a strictured hepatic duct. We studied and compared the influence of stricture severity, stricture length, eccentricity, and bile flow property on the bile flow dynamics. The bile flow velocity, pressure distribution, pressure drop, and wall shear stress are provided in detail. The stricture alters the normal bile flow pattern and increases flow resistance. At the location upstream and downstream of the stricture, bile flow slows down. In the area of the stricture throat, bile flow is accelerated, and recirculation forms behind the stricture. The maximum pressure drop of the biliary system increases with the stricture length. The eccentricity makes the flow deflect away from the duct's centerline. The behavior of the deflected flow is significantly altered downstream of the stricture. Such bile flow behavior as deceleration and recirculation may lead to cholestasis. Stricture alters bile flow in the biliary tract, causing changes in biliary hydrodynamic indexes, which could potentially serve as an omen for gallstone formation and other related diseases. The consideration of the bile duct stricture could lead to better patient stratification.
Scalp arteriovenous fistula (AVF) is an anomalous arteriovenous connection without a capillary bed. For symptomatic scalp AVFs, an appropriate treatment must be chosen. Currently, endovascular treatment (EVT) can serve as an alternative to surgical excision. However, EVT of scalp AVFs constitutes a challenge. A standard EVT strategy for scalp AVFs has not yet been established. Therefore, a review of current research on EVT for scalp AVFs is essential. In this review, the following issues were discussed: scalp vessel anatomy; etiology, angioarchitecture and classification of scalp AVFs; EVT principles and techniques; and EVT complications and prognosis. In addition, we attempted to propose a feasible grading system with 4 grades. Based on the literature review and our experience, we found that scalp AVFs have a complex angioarchitecture, which made EVT only possible in specific cases with low-grade scalp AVFs. EVT can be performed by transarterial or transvenous embolization. Direct puncture embolization can also be used for scalp AVFs. Complete occlusion of scalp AVF by EVT had low complication and recurrence rates and a good prognosis.
BACKGROUND: Sarcopenia, characterized by progressive muscle mass and function loss, particularly affects the elderly, and leads to severe consequences such as falls and mortality. Despite its prevalence, targeted pharmacotherapies for sarcopenia are lacking. Utilizing large-sample genome-wide association studies (GWAS) data is crucial for cost-effective drug discovery.
METHODS: Herein, we conducted four studies to understand the putative causal effects of genetic components on muscle mass and function. Study 1 employed a two-sample Mendelian randomization (MR) on 15,944 potential druggable genes, investigating their potential causality with muscle quantity and quality in a European population (N up to 461,089). Study 2 validated MR results through sensitivity analyses and colocalization analyses. Study 3 extended validation across other European cohorts, and study 4 conducted quantitative in vivo verification.
RESULTS: MR analysis revealed significant causality between four genes (BLOC-1 related complex subunit 7, BORCS7; peptidase m20 domain containing 1, PM20D1; nuclear casein kinase and cyclin dependent kinase substrate 1, NUCKS1 and ubiquinol-cytochrome c reductase complex assembly factor 1, UQCC1) and muscle mass and function (p-values range 5.98 × 10-6 to 9.26 × 10-55). To be specific, BORCS7 and UQCC1 negatively regulated muscle quantity and quality, whereas enhancing PM20D1 and NUCKS1 expression showed promise in promoting muscle mass and function. Causal relationships remained robust across sensitivity analyses, with UQCC1 exhibiting notable colocalization effects (PP·H4 93.4 % to 95.8 %). Further validation and in vivo replication verified the potential causality between these genes and muscle mass as well as function.
CONCLUSIONS: Our druggable genome-wide MR analysis identifies BORCS7, PM20D1, NUCKS1, and UQCC1 as causally associated with muscle mass and function. These findings offer insights into the genetic basis of sarcopenia, paving the way for these genes to become promising drug targets in mitigating this debilitating condition.