anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study explores the anti-inflammatory properties of lupeol, a notable phytosterol found in various medicinal plants, highlighting its potential as a candidate for new drug development. We examined the effects of lupeol on heme oxygenase (HO)-1, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs), as well as its impact on inflammatory markers in the lung tissues of LPS-challenged mice. Lupeol treatment enhanced HO-1 production, inhibited nuclear factor (NF)-κB activity, and reduced levels of COX-2/prostaglandin E2 (PGE2) and iNOS/nitric oxide (NO). In addition, lupeol decreased the phosphorylation of signal transducer and activator of transcription 1 (STAT-1) and promoted the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2), enhancing its binding to the anti-oxidant response element (ARE) and subsequently reducing interleukin (IL)-1β expression. In vivo, lupeol significantly lowered iNOS expression and tumor necrosis factor (TNF)-α levels in bronchoalveolar lavage fluid from LPS-treated mice. These findings suggest that lupeol exerts its anti-inflammatory effects by modulating key signaling pathways, positioning it as a promising candidate for the development of novel therapeutics targeting pathological inflammation.
Topical cosmetic and/or dermatological composition (A) to fight against signs of cutaneous ageing, comprises a blue lotus extract (I) (Nymphaea caerulea). Independent claims are also included for: (1) use of (I) in the preparation of (A) to fight against signs of cutaneous ageing; (2) cosmetic process comprising application of (A) on the zones of the affected of the skin; and (3) use of (I) for the preparation of a dermatological medicament for the prevention or treatment of uncontrolled facial muscular contractions. ACTIVITY : Relaxant; Dermatological. MECHANISM OF ACTION : Neurotransmitter inhibitor; P substance inhibitor. The ability of (A) to inhibit substance P was tested in rats using biological assays. The results showed that the (A) significantly inhibited the release of substance P.
Obsessive-compulsive disorder (OCD) affects nearly 1% of the pediatric population. The intrusive symptoms of this illness can interrupt normative development, causing significant psychological distress and producing life-long impairments in social, academic, and occupational functioning. Current research supports a neurobiologic model for OCD. Converging lines of evidence suggest that a post-infectious autoimmune-mediated process may be associated with the pathogenesis of some pediatric cases. This subgroup has been designated by the acronym, PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections). The abrupt symptom onset and relapsing-remitting course of illness characteristic of the PANDAS subgroup appears to define a distinct cohort of patients, in whom symptom exacerbations occur synchronously with Group A beta-hemolytic streptococcal (GABHS) infections.

We propose to perform prospective, longitudinal evaluations of a group of 72 children with recent onset OCD and 72 age-/sex-matched healthy volunteers. All children will undergo a comprehensive baseline assessment, including physical, neurological and psychiatric evaluations, neuropsychological testing, structural MRI and MRS scans, and laboratory assays. The children with OCD will be evaluated in the NIMH outpatient clinic at six-week intervals for a 28-month period to obtain prospective ratings of neuropsychiatric symptom severity, physical and neurological assessments, and anti-streptococcal antibody titers. At the end of the observation period, each OCD patient will be placed into a cohort based on the course of his or her symptoms: those displaying an acute onset and episodic course of OCD will be assigned to the "episodic" group, while those children with a gradual onset and stable course will comprise the "persistent" group. We hypothesize that the episodic group will have GABHS infections concurrent with their neuropsychiatric symptoms exacerbations and will meet criteria for the PANDAS subgroup. In contrast, children in the persistent group are not expected to have distinct periods of relapse nor a temporal association between GABHS infections and worsening of their symptoms. We expect that children in the PANDAS subgroup will demonstrate cross-reactive antibodies (antistreptococcal/antineuronal) during symptom exacerbations. At the conclusion of the study, we will perform group comparisons between the episodic OCD and persistent OCD cohorts, as well as between the patients and controls. The purpose of these comparisons is to identify baseline markers of membership in the PANDAS subgroup. The possibilities include distinctive HLA subtypes, quantitative differences in cytokines distribution, unique MRS chemical profiles, or a specific pattern of deficits on neuropsychological tests of basal ganglia function.
BACKGROUND: Pain management depends on continuous pain assessment and a pain concept. In particular, pain assessment and treatment are major challenges for nursing home residents (NHR) with cognitive impairment (CI). Many caregivers often lack the knowledge to recognize and appropriately treat pain in this vulnerable group. Little is known about the proportion of NHR who are fundamentally dependent on external assessment for pain due to CI.
OBJECTIVE: The aim of the study was to determine pain prevalence and management among NHR with and without CI. A second objective was to determine the proportion of NHR who are dependent on external assessment for pain.
METHODS: Information on pain was collected from 3,437 NHR in multicenter cross-sectional surveys in 51 German nursing homes between 2014 and 2018. The presence of current pain in one-to-one interviews was determined as well as dependencies on third-party information, number of daily pain recordings, and administration of medication for pain. The analysis included a contingency table and log regression analyses.
RESULTS: Pain prevalence was 24.9% among NHR with severe CI and 40.4% among NHR without CI. Overall, 19.8% of all NHRs relied on a third-party assessment of pain. Significantly, NHR with severe CI were less likely to be classified as having pain (OR 0.51), to be assessed for pain several times a day (OR 0.53) or to receive pain medication (OR 0.55) compared with NHR without CI. No influence on pain management was shown for the type of pain assessment.
CONCLUSIONS: The study provides evidence of significant deficits in pain management among NHR with moderate and severe CI in nursing homes in Germany. NHR with moderate and severe CI are significantly less likely to be observed for pain or classified as pain sufferers and receive significantly less pain medication than NHR without CI. Intensive training of staff on pain management of NHR with severe CI is recommended.
The measurement of cardiac output (CO) is important for a wide variety of patients under multiple conditions. At present, gold standard techniques for measurement of CO include velocity encoded phase contrast MRI. Both of these techniques are valid in patients with structural CHD. Disadvantages of these techniques include the requirement of significant time and expertise, and the high cost and anesthesia requirement. Accurate, non-invasive tools to measure CO could be extremely valuable for patients with CHD that require one-time of continuous monitoring of CO, such as during surgery, in intensive care settings, during other diagnostic testing, and during different physiologic states such as sleep and exercise. This study would begin by comparing cardiac output based on the PhysioFlow monitor to cardiac outout by MRI.

Impedance cardiography is performed by placing electrodes on the thorax and neck to measure electrical impedance over time. Cardiac output is derived from these measurements. The technique has been studied, validated, and used extensively in adults and has also been shown to be valid in children with structurally normal hearts. In contrast, recent studies of children with CHD have shown a relatively poor agreement between impedance cardiography and both thermodilution technique and velocity encoded phase contrast MRI. The reasons for the poor agreement in CHD patients is not yet understood. There are proprietary algorithms in each impedance device that use the raw data to calculate and report cardiac output. If the physiologic and/or anatomic differences of patients with CHD require changing the algorithm within each system to account for such differences, that needs to be done to each system. In order to do this, owners of any given device (PhysioFlow, NeuMeDx Inc. in this case) need access to the raw data in order to alter the algorithm. This study will involve a concerted effort between investigators at RCHSD, UCSD, and NeuMeDx
Subjects aged between and including 12 and 15 months at the time of booster vaccination who received the GSK217744 formulation A vaccine in the primary study and a booster dose of either GSK217744 formulation A vaccine (for subjects vaccinated before Protocol Amendment 2) or Infanrix hexa vaccine (for subjects vaccinated after Protocol Amendment 2) in this study, coadministered with a booster dose of Prevenar 13. The Infanrix hexa/GSK217744 and Prevenar 13 vaccines were administered intramuscularly into the right and left sides of the thigh, respectively.
<P>PROBLEM TO BE SOLVED: To obtain a medicine composition that contains diphenhydramine or its acid addition salt having improved dissolution and absorption characteristics in oral administration and being expected to more quickly develop sleepiness and a capsule packed with the medicine composition and to remarkably increase the effectiveness of the diphenhydramine preparation.  <P>SOLUTION: The medicine composition comprises 1 pt.wt. of diphenhydramine or its acid addition salt and 1-20 pts.wt. of macrogol. The capsule is packed with the medicine composition.  <P>COPYRIGHT: (C)2008,JPO&INPIT
This invention discloses a novel class of skincare products to remove iron in the skin and its preparation method. The core active components, termed as de-ironizing inducers (Dll), consist of a reducing agent and a precipitating agent. The reducing agent is selected from vitamin C, vitamin E, glutathione, vitamin A, vitamin D and their derivatives. The precipitating agent is chosen from calcium carbonate, pearl powder, magnesium carbonate, barium carbonate, calcium phosphate, magnesium phosphate, barium phosphate, calcium silicate, magnesium silicate, and barium silicate. Molar ratios of the reducing agent with the precipitating agent range from 1 :3-6 and the core components in the skin care product range from 5% to 10% w/w. The PH value of the skincare product is between 6.6 and 7.4. The skin care products can safely and effectively remove iron in the skin, which has been shown to accelerate skin's natural aging and photoaging.
While treatment with AZT has been found to be effective in prolonging survival and reducing the numbers of opportunistic infections in patients with AIDS, during the second year of administration of AZT an acceleration in mortality has been observed. The reasons for this are not known at this time. The study of what may be an AZT-resistant strain of HIV may benefit patients who have been and are still receiving AZT or another drug used in treating HIV ddC. It is hoped that the comparison of the effectiveness of AZT and ddC will benefit in the treatment of these patients.

Following tests to evaluate their health, patients are chosen at random to receive either AZT or ddC. AZT is given by mouth at the patients' current dose. ddC is given by mouth every 8 hours. Treatment continues for up to 12 months. Patients are required to visit the clinic every 2 weeks up to week 12 and then once a month. Blood samples are taken to monitor the safety and effectiveness of treatment.
Patients randomized into the denosumab group will receive denosumab 60mg subcutaneously every 6 months, for a total duration of 1 year. DEXA scan would be repeated at 1 year.
Depending on safety in this study, additional lower or intermediate dose levels may be evaluated. Depending on emerging safety data from the Phase 1a study 54F28-001 with continuing dose escalation, additional higher dose levels of OMP-54F28 may be evaluated in this study. Alternative dosing schedules of OMP-54F28 may be explored based on emerging nonclinical and clinical data for safety, PD, PK and efficacy. The starting dose for a new dosing schedule will be chosen to result in an AUC equivalent to the highest dose level that cleared on the previously studied dosing schedule. No dose escalation of OMP-54F28 will be allowed within a dose cohort.

Once the maximum tolerated dose (MTD) or maximum administered dose (MAD) has been determined, up to 10 patients may be enrolled in the cohort-expansion phase to better characterize the safety, tolerability and PK of OMP-54F28 combined with paclitaxel and carboplatin. Up to approximately 34 patients may be enrolled into the study.
PURPOSE: To obtain aspirin granules each having a specific size, coated with stomach-protecting film, having quick analgesic or antipyretic effect in humans through oral administration. CONSTITUTION: The dispersed aspirin granules, each of which has an average size of <250 (pref. 75-150)μm, are coated with stomach-protecting film selected from of cellulose acetate phthalate, poly(vinyl acetate phthalate), hydroxypropyl methyl cellulose phthalate and methacrylic acid-ethyl acrylate copolymer. In this case, the weight of the film accounts for 10-75 (esp. 30-35)wt.% of that of the coated granules. The aspirin is pref. of cubic crystal (the maximum dimension of the granule is no greater than double the second dimension thereof and also quadruple the minimum dimension thereof).
The invention discloses a method for preparing external rabdosia rubescens antibacterial cream. The method comprises the following steps of: (1) extracting crude medicine extract in rabdosia rubescens by a hot reflux method; (2) preparing an oil phase; (3) preparing an aqueous phase; and (4) heating the oil phase prepared in the step (2) and the aqueous phase prepared in the step (3) in a water bath at the temperature of between 50 and 70 DEG C, adding the aqueous phase into the oil phase, stirring, cooling to room temperature, and regulating the pH to 6.0 to 8.0 to prepare the cream. In the method, external skin cream is prepared from alcohol extract of the rabdosia rubescens produced in Jiyuan serving as a major ingredient. In-vitro bacteriostatic experiments show that the cream has the good inhibitory effect on bacillus thuringiensis, bacillus subtilis and staphylococcus aureus. Skin irritation tests of guinea pigs indicate that the cream does not have any irritation and is safe and reliable. The liquid medicine can reach lesion sites directly, is high in sterilizing power, quickly absorbed, quick in response, convenient to use and safe, does not harm internal organs and does not have any toxic or side effect.
FIELD: medicine and cosmetology. SUBSTANCE: invention involves using of thermal and/or mineral water with mineralization at least 400 mg/l in cosmetic and/or dermatological composition containing at least one active substance possessing side irritating effect. Active agent is keratolytical one of derivative type of salicylic acid. Composition containing the above-indicated water and active agent possessing irritating action is applied on skin for removal of acnes and wrinkles. EFFECT: reduced side effects. 21 cl, 1 tbl, 1 ex
The use of nutritional interventions have gained much attention and are being explored for their ability to increase muscle mass and/or attenuate loss of muscle mass. Leucine, isoleucine, and valine are branched chain amino acids that have been studied extensively and have been shown to stimulate muscle anabolism. Beta-hydroxy-beta-methylbutyrate (HMB), a metabolite of leucine, has been suggested to play a significant role in preserving muscle mass in situations that favor muscle mass loss. This is thought to occur through stabilizing sarcolemma integrity, reduced proteasome activity and expression of the proteasome 20S subunit, inhibition of apoptosis, and by activation of skeletal muscle satellite cells. Furthermore, in a catabolic-induced myotube and a murine adenocarcinoma cell line, HMB (50µM) was more potent in reversing the increased protein degradation and decreased protein synthesis compared to a higher dose of leucine (1mM). Similar findings were reported in a rodent cancer model. These data suggests that HMB plays a significant role in preventing muscle wasting.

Understanding the metabolic fate of HMB is crucial to developing strategies to increase HMB concentrations in populations that are subjected to muscle wasting. The objective of this application is to determine if a cholesterol lowering statin alters HMB metabolism in healthy adults. The Researchers will test the hypotheses that with statin administration, HMB metabolism and urinary excretion is affected and that this will have an unknown effect on the production of HMB and the response to intake of HMB precursors like leucine.
FIELD: medicine, oncology, pharmacy. SUBSTANCE: invention relates to an antitumor agent. Agent comprises stilbene derivative and coordination platinum compound as active components and pharmaceutically acceptable carriers. Invention provides the enhancement of an antitumor activity of pharmaceutical preparation in using these two types of active components in their combination and providing synergistic effect. An antitumor activity that is characteristic for stilbene is enhanced additionally resulting to an antitumor agent with the improved effectiveness being the latter is especially adequate in treatment of malignant tumors. EFFECT: enhanced and valuable medicinal properties of agent. 9 cl, 6 tbl
Abstract Systems for providing a reference plane for mounting an acetabular cup are disclosed. A patient is positioned in a supine position on an upper surface of a platform, such as a surgical table. One or more arrays or navigational references can be mounted to the upper surface of the platform to define a reference plane. This reference plane can be used as a substitute or proxy for the anterior pelvic plane, which is associated with the patient's pelvic bone. Other arrays or navigational references can be mounted to the patient's pelvic bone to define a second reference plane. Using either or both reference planes, a surgeon using a computer-aided surgical procedure can align and mount an acteabular cup or component with respect to the patient's pelvic bone.
Studies have highlighted the importance of applying Behavioral Sciences interventions to develop equity in the prevention of chronic diseases in the public health domain. Our study aims to assess the evidence of this influence. We undertook a systematic review study using the electronic databases PubMed, Web of Science, Scopus and Cochrane, searching for work published between 2013 and 2023. The research analyzed the influence of Behavioral Sciences intervention studies on public health. This review was registered and published in PROSPERO, registration number CRD42023412377. The systematic search identified 2951 articles. The review analyzed 26 studies. The quality assessment of the articles showed an overall average of 74%, with the majority of studies being of high quality. The interventions with the best evidence for chronic diseases used framing messages, nudges and vouchers. Messages with incentives also showed satisfactory evidence. The most prevalent outcomes were related to screening tests and patient adherence to treatment. The current state of decision-making remains mainly at the patient level, with potential for further exploration of the roles of healthcare professionals and decision-makers in future research efforts. Limitations relate to the heterogeneity of the study sample, which hinders a more precise analysis of specific interventions and outcomes in chronic diseases.
<P>PROBLEM TO BE SOLVED: To provide a pack preparation for argotherapy or an argo esthetic clinic using seaweed especially brown alga seaweed, the use thereof, an instrument for practicing the use thereof and a set of materials and instruments for practicing the use.  <P>SOLUTION: (1): Seaweed, especially brown alga seaweed is mashed and paste is made. (2): The following components of optimum dose are added to this paste and kneaded to make a pack preparation: (a) the paste, (b) a granodiorite powder, (c) an organic moisturizer, (d) a composite amino acid supplement, and (e) iceberg deep water. (3): This pack preparation is applied to a part or whole body after a bath is taken or not in a microbubble bathtub. (4): An upper part body is covered with a heat insulation drapery and is kept warm after lying on the back on a mat for waterproof bed covering or not covering with a porous carbonization ceramic sheet and a bed sheet.  <P>COPYRIGHT: (C)2008,JPO&INPIT
BACKGROUND: Accurate detection of lymph node metastasis (LNM) is crucial for determining the tumor stage, selecting optimal treatment, and estimating the prognosis for cervical cancer. This study aimed to assess the diagnostic efficacy of multimodal diffusion-weighted imaging (DWI) and morphological parameters alone or in combination, for detecting LNM in cervical cancer.
METHODS: In this prospective study, we enrolled consecutive cervical cancer patients who received multimodal DWI (conventional DWI, intravoxel incoherent motion DWI, and diffusion kurtosis imaging) before treatment from June 2022 to June 2023. The largest lymph node (LN) observed on each side on imaging was matched with that detected on pathology to improve the accuracy of LN matching. Comparison of the diffusion and morphological parameters of LNs and the primary tumor between the positive and negative LN groups. A combined diagnostic model was constructed using multivariate logistic regression, and the diagnostic performance was evaluated using receiver operating characteristic curves.
RESULTS: A total of 93 cervical cancer patients were enrolled: 35 with LNM (48 positive LNs were collected), and 58 without LNM (116 negative LNs were collected). The area under the curve (AUC) values for the apparent diffusion coefficient, diffusion coefficient, mean diffusivity, mean kurtosis, long-axis diameter, short-axis diameter of LNs, and the largest primary tumor diameter were 0.716, 0.720, 0.716, 0.723, 0.726, 0.798, and 0.744, respectively. Independent risk factors included the diffusion coefficient, mean kurtosis, short-axis diameter of LNs, and the largest primary tumor diameter. The AUC value of the combined model based on the independent risk factors was 0.920, superior to the AUC values of all the parameters mentioned above.
CONCLUSION: Combining multimodal DWI and morphological parameters improved the diagnostic efficacy for detecting cervical cancer LNM than using either alone.