anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND AND OBJECTIVES: Maximizing the extent of resection (EOR) improves outcomes in glioblastoma (GBM). However, previous GBM studies have not addressed the EOR impact in molecular subgroups beyond IDH1/IDH2 status. In the current article, we evaluate whether EOR confers a benefit in all GBM subtypes or only in particular molecular subgroups.
METHODS: A retrospective cohort of newly diagnosed GBM isocitrate dehydrogenase (IDH)-wildtype undergoing resection were prospectively included in a database (n = 138). EOR and residual tumor volume (RTV) were quantified with semiautomated software. Formalin-fixed paraffin-embedded tumor tissues were analyzed by targeted next-generation sequencing. The association between recurrent genomic alterations and EOR/RTV was evaluated using a recursive partitioning analysis to identify thresholds of EOR or RTV that may predict survival. The Kaplan-Meier methods and multivariable Cox proportional hazards regression methods were applied for survival analysis.
RESULTS: Patients with EOR ≥88% experienced 44% prolonged overall survival (OS) in multivariable analysis (hazard ratio: 0.56, P = .030). Patients with alterations in the TP53 pathway and EOR <89% showed reduced OS compared to TP53 pathway altered patients with EOR>89% (10.5 vs 18.8 months; HR: 2.78, P = .013); however, EOR/RTV was not associated with OS in patients without alterations in the TP53 pathway. Meanwhile, in all patients with EOR <88%, PTEN -altered had significantly worse OS than PTEN -wildtype (9.5 vs 15.4 months; HR: 4.53, P < .001).
CONCLUSION: Our results suggest that a subset of molecularly defined GBM IDH-wildtype may benefit more from aggressive resections. Re-resections to optimize EOR might be beneficial in a subset of molecularly defined GBMs. Molecular alterations should be taken into consideration for surgical treatment decisions in GBM IDH-wildtype.
Subacromial impingement is the condition, in which the tissue underlying subacromial spaces are compressed between the head of the humerus and the acromion, is one ofthe main diagnoses of shoulder pain. Subjects frequently experience pain when engaging in anyoverhead activity.In general, medical practice, pain in the glenohumeral region is commonmusculoskeletal problem has almost 48% prevalence. Cervicothoracic junction refers to atherapeutic technique or manual therapy approaches that focuses on improving mobility andfunction in this area where the cervical neck and upper back spine meet. Upper thoracic manipulation refers to a manual technique used to address dysfunctions or restrictions in the upper portion of the thoracic vertebral region, which is the area of the thoracic vertebrae located between the cervical and mid back regions.Previously, studies were conducted individually to determine effectiveness of upper thoracic mobilization and cervico-thoracic mobilization with arm movement for treatment of subacromial bursitis. However, fewer studies were previously conducted to compare the effects of both treatment methods (mobilization and manipulation). This study specifically focuses on the comparative effects of upper thoracic and cervico-thoracic mobilization.
Perineural invasion (PNI) is an essential form of tumor metastasis in multiple malignant cancers, such as pancreatic cancer, prostate cancer, and head and neck cancer. Growing evidence has revealed that pancreatic cancer recurrence and neuropathic pain positively correlate with PNI. Therefore, targeting PNI is a proper strategy for pancreatic cancer treatment. Exosomal lncRNA derived from pancreatic cancer cells is an essential component of the tumor microenvironment. However, whether exosomal lncXIST derived from pancreatic cancer cells can promote PNI and its exact mechanism remains to be elucidated. We show that lncXIST mediates nerve-tumor crosstalk via exosomal delivery. Our data reveal that exosomal lncXIST derived from pancreatic cancer cells is delivered to neural cells and promotes their release of glial-cell-line-derived neurotrophic factor (GDNF), essential in facilitating the PNI of pancreatic cancer. Mechanistically, microRNA-211-5p negatively regulates GDNF, and lncXIST serves as a miR-211-5p sponge. The function of exosomes in the dynamic interplay between nerves and cancer is confirmed in both in vivo and in vitro PNI models. Therefore, targeting pancreatic cancer cell-derived exosomal lncXIST may provide clues for a promising approach for developing a new strategy to combat PNI of pancreatic cancer.
Novel 1,2,4-benzotriazine derivatives of the formula I <IMAGE> are prepared. In this formula, X and Y denote hydrogen, alkyl, alkoxy, phenoxy, substituted phenoxy or halogen, R1 and R2 represent hydrogen, alkyl having 1 to 12 carbon atoms, which can be substituted by hydroxyl, lower alkoxy or carboxyl, cycloalkyl, aryl, aralkyl or a heterocyclic radical, with the proviso that one of the radicals R1 and R2 can only be CH3 if the other radical R1 or R2 does not have the meaning of H, or R1 and R2 together with the adjacent nitrogen atom represent a morpholino, piperidino or pyrrolo group, or R1 represents  beta -dimethylaminoethyl, if R2, X and Y represent hydrogen. The novel compounds are obtained by reaction of compounds of the formula II <IMAGE> with the appropriate amines. The novel benzotriazine compounds have useful microbicidal properties which make them suitable for use both in the veterinary medical sector and in the protection of materials. They display disinfecting and preserving actions in the control of pathogenic and material-damaging microorganisms. Moreover, they are used for promoting the growth of productive animals.
PURPOSE:To readily obtain a high-quality solid powdery cosmetic without requiring much time for mixing and stirring, by stirring and mixing a powdery cosmetic base material with a fluorocarbon, filling the resultant mixture in a container and volatilizing the fluorocarbon. CONSTITUTION:A fluorocarbon having <=110 deg.C boiling point is stirred and mixed with a powdery cosmetic base material to provide a granular or powdery sub stance, which is then filled in a cosmetic container. The fluorocarbon is subse quently volatilized and molding is carried out to afford the aimed substance. The amount of the blended fluorocarbon is 20-80wt.% expressed in terms of weight concentration in mixing. The fluorocarbon is a colorless, transparent and inert liquid having extremely low surface tension and excellent permeability without dissolving most of cosmetic base materials. Fluorinert FC-72(R) manufac tured by Sumitomo 3M Ltd. is exemplified as the fluorocarbon.
In some aspects a process for forming deodorant or antiperspirant soft solid in which a mobile deodorant or antiperspirant composition is filled into dispensing containers by injection moulding, i.e. a process in which the deodorant or antiperspirant composition is filled under pressure. The composition at the time of injection moulding is preferably in the vicinity of its normal setting temperature. The deodorant or antiperspirant composition is preferably continuously produced in a screw extruder (3), especially a twin screw extruder (4, 5), which is controlled to deliver the composition in a suitably viscous state under low shear, at a temperature in the vicinity of its normal setting temperature. Use of the twin screw extruder is particularly advantageous for formulations in which a particulate antiperspirant is suspended in a fluid carrier. It is injected into the container at a head pressure at the point of injection that is greater than 120 kPa and in many instances from 800 to 2000 kPa in the injection head. The combined process offers benefits for controlled fill of dispensing containers, particularly for formulations incorporating sensitive ingredients and offers tolerance in composition temperature at the time of fill.
PURPOSE: A curing composition containing L-arginine, Schizandrae Fructus extract, Eucommiae Cortex extract for impotency is provided, which shows good curing effect to impotency without side-effect. CONSTITUTION: The curing composition for impotency comprises of L-arginine crystalline powder 5-200wt. part, Schizandrae Fructus extract containing 0.1-0.5% of schizandrin 3-15wt. part and Eucommiae Cortex extract containing 0.02-0.12% of genipocidic aid 5-15wt. part. The composition shows enhanced living body activity effect by adding vitamin B, C, E, pantothenic aicd or folic acid, which can be prepared in the form of solution, suspension, tablets, capsules, soft capsules, pills or granules. A process for the preparation of Eucommiae Cortex extract comprises of: cutting the Eucommiae Cortex into fine pieces, and pouring into distilled water 10L; boiling for 3hrs in water bath, and filtering after cooling; concentrating the residual solution to get the genipodic acid contained powder. A process for the preparation of Schizandrae Fructus extract comprises of: cutting the Schizandrae Fructus into fine pieces, and pouring into distilled water 5L; boiling for 3hrs in water bath, and filtering after cooling; and concentrating the residual solution to get the powder.
Group B:25 patients included. Linea alba will be closed with Modified Smead jones technique with Far-near near-far technique.
Chronic kidney disease (CKD) is linked to greater prevalence and rapid progression of calcific aortic valve disease (CAVD) characterized by valvular leaflet fibrosis and calcification. Fibroblast growth factor 23 (FGF23) level is elevated, and anti-aging protein Klotho is reduced in CKD patients. However, the roles of FGF23 and Klotho in the mechanism of aortic valve fibrosis and calcification remain unclear. We hypothesized that FGF23 mediates CKD-induced CAVD by enhancing aortic valve interstitial cell (AVIC) fibrosis and calcification, while soluble Klotho inhibits FGF23 effect. Methods and Results: In an old mouse model of CKD, kidney damages were accompanied by aortic valve thickening and calcification. FGF23 levels in plasma and aortic valve were increased, while Klotho levels were decreased. Recombinant FGF23 elevated the inflammatory, fibrogenic, and osteogenic activities in AVICs. Neutralizing antibody or shRNA targeting FGF23 suppressed the pathobiological activities in AVICs from valves affected by CAVD. FGF23 exerts its effects on AVICs via FGF receptor (FGFR)/Yes-associated protein (YAP) signaling, and inhibition of FGFR/YAP reduced FGF23's potency in AVICs. Recombinant Klotho downregulated the pathobiological activities in AVICs exposed to FGF23. Incubation of FGF23 with Klotho formed complexes and decreased FGF23's potency. Further, treatment of CKD mice with recombinant Klotho attenuated aortic valve lesions. Conclusion: This study demonstrates that CKD induces FGF23 accumulation, Klotho insufficiency and aortic valve lesions in old mice. FGF23 upregulates the inflammatory, fibrogenic and osteogenic activities in AVICs via the FGFR/YAP signaling pathway. Soluble Klotho suppresses FGF23 effect through molecular interaction and is capable of mitigating CKD-induced CAVD.
Recurrent abdominal pain is a common complaint among school-age children, being present in up to 15% at any given time. It represents the most common chronic pain entity in pediatric patients. The great majority of these patients will have a functional gastrointestinal disorder (FGID). The most common FGID in these patients is functional dyspepsia (FD), defined as upper abdominal pain or discomfort unrelieved by bowel movement and in the absence of a structural or biochemical explanation for the pain. The etiology of FD is multifactorial, including biological factors, and these factors can be viewed within a biopsychosocial model. Biological factors include inflammation, dysmotility and increased visceral sensitivity. These biological factors are influenced by and are interactive with psychosocial factors such as anxiety, depression and social interaction. This study will evaluate intestinal permeability as a measure of barrier dysfunction and investigate the correlations between increased permeability, mucosal inflammation and anxiety scores to provide further insight into the etiology of FD, thereby assisting in the development and selection of treatment modalities.
PURPOSE:To enhance the water retentivity in a product and to enhance and keep cooling effect, by preparing a poultice by providing an adhesive layer to the single surface of a water swellable fiber cloth like body composed of a fiber material wherein a hydrophilic crosslinked polymer is bonded to a synthetic fiber having water absorbability of a specific value or more and held to a dry state. CONSTITUTION:A fiber material wherein a hydrophilic crosslinked polymer is bonded to a synthetic fiber may be formed by bonding the hydrophilic crosslinked polymer to the synthetic fiber in a degree not separated by usual force. For example, the synthetic fiber such as an acrylic fiber is used as a core and an outer layer composed of the hydrophilic crosslinked polymer such as sodium polyacrylate or a sodium acrylate/acrylamide copolymer is provided to the periphery of the core. The water absorbability of said fiber is 30ml/g or more, pref., 150ml/g or more. An adhesive is prepared by kneading a medicinal component such as corticosteroid and/or components such as an excipient, an adhesiveness imparting agent, an oxidation inhibitor, fragrance or a colorlant with an oleophilic adhesive substance. The adhesive thus prepared is uniformly applied to the single surface of the water-swellable fiber cloth like body and a separator is laminated to the surface of the adhesive layer.
Patients in the low-high-low group will receive an infusion of propofol with an initial blood target concentration of 2 mcg/ml. After 15 minutes the target will be increased to 5 mcg/ml and after a further 15 minutes the target will be reduced back to 2 mcg/ml for a further 15 to 30 minutes.
Each participant will be provided with the FitRight® System for the duration of the study. The study products will be used to collect real-life measurement data in order to assess the FitRight® System. Each participant will be asked to wear at least three briefs so that they are wearing each brief during the simulated voids performed by the site staff. The site staff will perform the simulated void by addition of (90-360 mL normal saline to the brief. The FitRight® System will be assessed for alerts while participants are in the following positions: supine, sitting, and laying on either left or right side. Each participant will be randomized to either the left or right side. Twenty-two of the fifty-six participants will perform rewet testing procedures. The study results will be used to assess the reliability of the device's absorption to trigger an alert
The Internet of Things (IoT) is capable of controlling the healthcare monitoring system for remote-based patients. Epilepsy, a chronic brain syndrome characterized by recurrent, unpredictable attacks, affects individuals of all ages. IoT-based seizure monitoring can greatly enhance seizure patients' quality of life. IoT device acquires patient data and transmits it to a computer program so that doctors can examine it. Currently, doctors invest significant manual effort in inspecting Electroencephalograph (EEG) signals to identify seizure activity. However, EEG-based seizure detection algorithms face challenges in real-world scenarios due to non-stationary EEG data and variable seizure patterns among patients and recording sessions. Therefore, a sophisticated computer-based approach is necessary to analyze complex EEG records. In this work, the authors proposed a hybrid approach by combining traditional convolution neural (CN) and recurrent neural networks (RNN) along with an attention mechanism for the automatic recognition of epileptic seizures through EEG signal analysis. This attention mechanism focuses on significant subsets of EEG data for class recognition, resulting in improved model performance. The proposed methods are evaluated using a publicly available UCI epileptic seizure recognition dataset, which consists of five classes: four normal conditions and one abnormal seizure condition. Experimental results demonstrate that the suggested approach achieves an overall accuracy of 97.05% for the five-class EEG recognition data, with an accuracy of 99.52% for binary classification distinguishing seizure cases from normal instances. Furthermore, the proposed intelligent seizure recognition model is compatible with an IoMT (Internet of Medical Things) cloud-based smart healthcare framework.
N-Phenyl-N-piperdinyl)amide derivatives are disclosed having the general formula (I).     (see fig.I) wherein: X is a member selected from the group consisting of:      alkoxy-carbonyl-lower alkyl, lower alkyl-carbor-lyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C1-2)alkoxy-(C1-2)alkoxy-carbonyl-lower alkyl. Ar is a member selected from the group consisting of phenyl, mono-, di- and tri-substituted phenyl, wherein each subtitutuent is independently selected from the group consisting of halo, lower alkyl, lower alkoxy and trifluoromethyl; R is a member selected from the group consisting of lower alkyl, and lower alkoxy-lower alkyl; R1 is a member selected from the group consisting of hydrogen, lower alkoxy-carbonyl, and methoxymethyl; and R2 is a member selected from the group consisting of hydrogen and methyl; and the diastereomeric and enantiomeric isomers thereof, and the acid addition salts of said compounds and isomers.     The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).
CIN-103 Dose 1, administered as 2 x CIN-103 capsules and 2 x matching placebo per dose. Two doses per day.
BACKGROUND: Pharyngeal flap (PF) surgery is effective at improving velopharyngeal sufficiency, but historical literature shows a concerning prevalence rate of obstructive sleep apnea (OSA), reported as high as 20%. Our institution has developed a protocol to minimize risk of postoperative obstructive complications and increase safety of PF surgery. We hypothesize that (1) preoperative staged removal of significant adenotonsillar tissue along with (2) multiview videofluoroscopy to guide patient-specific surgical approach via appropriately sized PFs can result in excellent speech outcomes while limiting occurrence of OSA.
METHODS: This was a retrospective chart review of all patients with velopharyngeal insufficiency (VPI) (aged 2-20 years) seen at the University of Rochester from 2015 to 2022 undergoing PF surgery to correct VPI. Nasopharyngoscopy was used for surgical planning and airway evaluation. Patients with tonsillar and adenoid hypertrophy underwent staged adenotonsillectomy at least 2 months before PF. Multiview videofluoroscopy was used to identify anatomic causes of VPI and to determine PF width. Patients underwent polysomnography and speech evaluation before and at least 6 months after PF surgery.
RESULTS: Forty-one children aged 8.5 ± 4.1 years (range, 4 to 18 years) who underwent posterior PF surgery for VPI were identified. This included 10 patients with 22q11.2 deletion and 4 patients with Pierre Robin sequence. Thirty-nine patients had both pre- and postoperative speech data and underwent both a pre- and postoperative sleep study. Polysomnography showed no significant difference in obstructive apnea-hypopnea index after posterior PF surgery (obstructive apnea-hypopnea index preop, 1.3 ± 1.2 events per hour; postop, 1.7 ± 2.1 events per hour; P = 0.111). Significant improvements in speech outcome were seen in patients who underwent PF (modified Pittsburgh score preop, 11.52 ± 1.37; postop, 1.09 ± 2.35; P < 0.05).
CONCLUSIONS: Use of preoperative staged adenotonsillectomy as well as patient-specific PF dimensions results in effective resolution of VPI and a low risk of OSA.
Ancient DNA is a valuable tool for investigating genetic and evolutionary history that can also provide detailed profiles of the lives of ancient individuals. In this study, we develop a generalised computational approach to detect aneuploidies (atypical autosomal and sex chromosome karyotypes) in the ancient genetic record and distinguish such karyotypes from contamination. We confirm that aneuploidies can be detected even in low-coverage genomes ( ~ 0.0001-fold), common in ancient DNA. We apply this method to ancient skeletal remains from Britain to document the first instance of mosaic Turner syndrome (45,X0/46,XX) in the ancient genetic record in an Iron Age individual sequenced to average 9-fold coverage, the earliest known incidence of an individual with a 47,XYY karyotype from the Early Medieval period, as well as individuals with Klinefelter (47,XXY) and Down syndrome (47,XY, + 21). Overall, our approach provides an accessible and automated framework allowing for the detection of individuals with aneuploidies, which extends previous binary approaches. This tool can facilitate the interpretation of burial context and living conditions, as well as elucidate past perceptions of biological sex and people with diverse biological traits.
The invention provides paeonia suffruticosa nourishing tea and a preparation method thereof and relates to a beverage. The paeonia suffruticosa nourishing tea is soup obtained by mixing and immersing paeonia suffruticosa petals, an extracting solution of auxiliary materials and a condiment. The auxiliary material raw materials comprise radix ophiopogonis, dendrobium nobile, polygonatum sibiricum, polygonatum odoratum, cistanche deserticola, fructus ligustri lucidi, astragalus membranaceus, rehmannia glutinosa, bighead atractylodes rhizomes, cornus officinalis, momordica grosvenori, tremella, lily powder, medlar, lotus seeds, dried water chestnuts, couch grass roots, acanthopanax senticosus, jujube slices, prepared glycyrrhizae, Chinese yams and radix pseudostellariae. The use amount of the paeonia suffruticosa petals is 7-8% of the weight of the auxiliary materials. The paeonia suffruticosa petals are paeonia suffruticosa petals with oil films and oil on the surfaces removed at low temperature. The extracting solution of the auxiliary materials is an extracting solution obtained by drying and frying the auxiliary materials, and then adding water and boiling; the ratio of the weight of the auxiliary materials to the volume of the extracting solution is 131g to 5000ml. The paeonia suffruticosa nourishing tea is prepared from the pure paeonia suffruticosa and traditional Chinese medicines so that the paeonia suffruticosa nourishing tea not only can help to produce saliva and slake thirst, but also has the effects of nourishing yin and moisturizing lung, nourishing liver and kidney, replenishing vital essence to improve eyesight, calming the nerves and enriching blood, tonifying spleen and tonifying deficiency, tonifying middle-jiao and qi, improving immunity and the like.
Richter syndrome (RS) describes a phenomenon in which a patient with chronic lymphocytic leukemia (CLL) develops an aggressive lymphoma, most commonly diffuse large B-cell lymphoma (DLBCL). Reports of cutaneous RS remain exceedingly rare. We report a 61-year-old woman with relapsed/refractory CLL presenting with several subcutaneous nodules on her arms and legs and a single dermal plaque on her abdomen. Skin biopsy revealed a diagnosis of DLBCL, ABC-type, and her clinical status rapidly deteriorated following diagnosis. We review the variety of clinical presentations of cutaneous RS, its association with CLL, risk factors for RS development in CLL patients, and the distinctive histopathologic and immunophenotypic features of DLBCL. We hope to highlight the importance of prompt skin biopsy in patients with CLL presenting with progressive skin lesions and increase awareness of this aggressive clinical syndrome.