anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a highly safe thrombolytic agent useful for preventing and treating diseases caused by thrombosis by including a fermentation product of soybean curd refuses with a specific bacterium. SOLUTION: This thrombolytic agent contains the fermentation product of soybean curd refuses with Bacillus natto. The fermentation product is obtained e.g. by adjusting the water content of soybean curd refuses by-produced in a process for producing soy bean curds, etc., to about 70-80 wt.%, sterilizing the soybean curd refuses at a temperature of 105-130 deg.C at a pressure of 1.2-3 kg/cm<2> , etc., inoculating a Bacillus natto such a Takahasi bacterium in the sterilized soybean curd refuses in an amount of 10<3> -10<6> cells/g (converted into the weight of dry soybean curd refuses), fermenting the refuses at a temperature of 20-40 deg.C for 10 hr or longer, and further fermenting the refuses at a temperature of 20-25 deg.C for 15-20 hr. The fermentation product is mixed with other additives. prepared in the form of powder, etc., and subsequently orally administered.  The fermentation product is also prepared in the form of functional foods such as semi-raw type sticks, biscuits, etc.
The present invention relates to a compound injection preparation containing effective parts of traditional Chinese medicine and used for treating cardio-cerebrovascular diseases, and a preparation method. The compound preparation is prepared from the following components according to the proportion by weight: 1 part of chuanxiongzine and 0.1 to 10 parts of breviscapine, and the compound injection preparation is also prepared. The compound injection preparation of the present invention enhances the pharmacological effect and the effect time of the traditional oral medicine. Compared with the medicine effect of borneol or acanthopanax root extracts, the medicine effect of the compound injection preparation is obviously enhanced. The compound injection preparation is used for treating cerebral infarction, cerebral ischemia, coronary heart diseases, angina pectoris, myocardial infarction, etc. The compound injection preparation has the characteristics of quick effect taking, obvious effect, high safety and high stability.
Enterococcus faecalis is a common cause of healthcare-acquired bloodstream infections and catheter-associated urinary tract infections (CAUTIs) in both adults and children. Treatment of E. faecalis infection is frequently complicated by multi-drug resistance. Based on protein homology, E. faecalis encodes two putative hyaluronidases, EF3023 (HylA) and EF0818 (HylB). In other Gram-positive pathogens, hyaluronidases have been shown to contribute to tissue damage and immune evasion, but the function in E. faecalis has yet to be explored. Here, we show that both hylA and hylB contribute to E. faecalis pathogenesis. In a CAUTI model, ΔhylA exhibited defects in bladder colonization and dissemination to the bloodstream, and ΔhylB exhibited a defect in kidney colonization. Furthermore, a ΔhylAΔhylB double mutant exhibited a severe colonization defect in a model of bacteremia while the single mutants colonized to a similar level as the wild-type strain, suggesting potential functional redundancy within the bloodstream. We next examined enzymatic activity, and demonstrate that HylB is capable of digesting both hyaluronic acid (HA) and chondroitin sulfate in vitro, while HylA exhibits only a very modest activity against heparin. Importantly, HA degradation by HylB provided a modest increase in cell density during the stationary phase and also contributed to dampening of lipopolysaccharide-mediated NF-κB activation. Overall, these data demonstrate that glycosaminoglycan degradation is important for E. faecalis pathogenesis in the urinary tract and during bloodstream infection.
This is an observational prospective cohort study will conduct at Obstetrics and Gynecology Department of Cengiz Gokcek Obstetrics and Children's Hospital between April and October 2019. One hundred women will enrol in the study in two groups. We will consecutively recruit 50 pregnancies complicated with preeclampsia, and 50 healthy pregnancies will select for the control group. All patients will give their oral and written informed consent before their inclusion in the study. The protocol was approved by the Ethics Committee for Clinical Research of Gaziantep University (Reference number: 2019/147). The study strictly will adhere to the principles of the Declaration of Helsinki.
PURPOSE: A producing method of black garlic jelly is provided to enable children to eat the black garlic jelly as a snake, and to easily produce the black garlic jelly. CONSTITUTION: A producing method of black garlic in a jelly type comprises the following steps: washing garlic in water, and removing the moisture before naturally drying; aging the dried garlic at 80 deg. C for 3 days to obtain black garlic; crushing the black garlic into 3-5mm; soaking the crushed black garlic in a solution containing agar, cinnamon, a green tea extract, citric acid, and chokeberry juice, and boiling the mixture in an extractor at 100-120 deg. C for 1-3 hours; steaming the obtained black garlic powder at 100 deg. C for 5-7 minutes; soaking the steamed garlic powder in soaking liquid for 24-48 hours; and naturally cooling the powder at 60 deg. C before pouring into a molding frame for cooling at 20-25 deg. C for 24 hours. [Reference numerals] (AA) Assorting, washing, drying; (BB) Aging; (CC) Crushing; (DD) Mixing in a boiling pot; (EE) Steaming; (FF) Preserving; (GG) Molding
The present invention relates to a streptococcus adhesion antigen GAPDH and a preparation method thereof. The GAPDH is an rGAPDH, which has high conservative property and sequence homology, consists of 319 amino acid residues, and has a molecular weight of 32.4kDa. The rGAPDH is encoded by a gapdh gene; and a forward primer and a reverse primer of the gapdh gene respectively have one restriction enzyme cutting site at 5' and 3'. The preparation method of the GAPDH comprises the following steps of: PCR amplification, connection to a carrier, transformation and induction, and purification. The rGAPDH and an SEZ (Streptococcus zooepidemicus) rehabilitation pig serum show good immune responses; the rGAPDH can protect SEZ infected mice with limitation; and the mice immunized by the rGAPDH show high level of antibody titer in serum. An anti-GAPDH antibody can induce high level of bactericidal capability; a gapdh gene has a transcription level in SEZ infected mice much higher than that of culture in vitro; and the rGAPDH can significantly weaken cell adhesion ability of the SEZ, and greatly reduce cell infection ability of the SEZ.
Rates of mental health and substance use disorders are high among economically disadvantaged, ethnic minority populations. Studies have shown that CBT designed for this high-risk population is successful at reducing suicide attempts in people with suicidal thoughts or attempts. This study will implement a CBT intervention into the community and will focus on increasing compliance with psychiatric, substance abuse, and medical treatment.

Participants in this study will be randomly assigned to receive either CBT plus standard care or standard care alone. Participants who receive CBT will have ten weekly sessions of treatment. Suicidal thoughts or attempts, hopelessness, depression, health care utilization, and overall psychological and social adaptation will be assessed. Assessments will be made 1, 3, 6, 12, 18, and 24 months after study completion.
The invention discloses a nucleic acid transfected cationic liposome, a nucleic acid medicinal preparation comprising a cationic liposome as well as a preparation method and use thereof. The cationic liposome comprises a cationic liposome, an auxiliary liposome and a polyethylene glycol modified neutral liposome. The cationic liposome nucleic acid medicinal preparation comprises the cationic liposome and the nucleic acid medicinal preparation. The cationic liposome disclosed by the invention serves as a non-virus gene vector and is low in cytotoxicity, strong in blood stability and high in gene silencing efficiency. The highest gene silencing efficiency on a HepG-2 cell which constantly expresses luciferase is 90.8%. The cationic liposome has an excellent anti-non-specific protein adsorptive property and long recyclability, thus improving the stability and the running efficiency of the liposome and effectively improving the effect of the nucleic acid medicine. The cationic liposome nucleic acid medicinal preparation can be used in the field of medicine and the like.
Distribution: 11C-choline distributes mainly to the pancreas, kidneys, liver, spleen and colon [see Dosage and Administration (2.4)]. Based upon the relatively low urinary excretion of radioactivity, renal distribution is predominantly to the organ itself, rather than via formation of urine.

Metabolism: Following intravenous administration, 11C-choline undergoes metabolism resulting in the detection of 11C‑betaine as the major metabolite in blood. In a study of patients with prostate cancer or brain disorders, the fractional activities of 11C-choline and 11C-betaine in human arterial plasma appeared to reach a plateau within 25 minutes, with 11C‑betaine representing 82% ± 9% of the total 11C detected at that time point. A small amount of unmetabolized 11C‑choline was detected within the blood at the final sampling time point (40 minutes). 

Elimination: Urinary excretion of 11C-choline was < 2% of the injected radioactivity at 1.5 hours after injection of the drug. The rate of 11C-choline excretion in urine was 0.014 mL/min.
Cancer cachexia is a complex systemic wasting syndrome. Nutritional mechanisms that span energy intake, nutrient metabolism, body composition, and energy balance may be impacted by, and may contribute to, the development of cachexia. To date, clinical management of cachexia remains elusive. Leaning on discoveries and novel methodologies from other fields of research may bolster new breakthroughs that improve nutritional management and clinical outcomes. Characteristics that compare and contrast cachexia and obesity may reveal opportunities for cachexia research to adopt methodology from the well-established field of obesity research. This review outlines the known nutritional mechanisms and gaps in the knowledge surrounding cancer cachexia. In parallel, we present how obesity may be a different side of the same coin and how obesity research has tackled similar research questions. We present insights into how cachexia research may utilize nutritional methodology to expand our understanding of cachexia to improve definitions and clinical care in future directions for the field.
Powdery mildew poses a significant threat to wheat crops worldwide, emphasizing the need for durable disease control strategies. The wheat-Dasypyrum villosum T5AL·5 V#4 S and T5DL·5 V#4 S translocation lines carrying powdery mildew resistant gene Pm55 shows developmental-stage and tissue-specific resistance, whereas T5DL·5 V#5 S line carrying Pm5V confers resistance at all stages. Here, we clone Pm55 and Pm5V, and reveal that they are allelic and renamed as Pm55a and Pm55b, respectively. The two Pm55 alleles encode coiled-coil, nucleotide-binding site-leucine-rich repeat (CNL) proteins, conferring broad-spectrum resistance to powdery mildew. However, they interact differently with a linked inhibitor gene, SuPm55 to cause different resistance to wheat powdery mildew. Notably, Pm55 and SuPm55 encode unrelated CNL proteins, and the inactivation of SuPm55 significantly reduces plant fitness. Combining SuPm55/Pm55a and Pm55b in wheat does not result in allele suppression or yield penalty. Our results provide not only insights into the suppression of resistance in wheat, but also a strategy for breeding durable resistance.
Participants in the usual care arm will not receive weekly subsidies on Instacart, and they will not receive any modifications to the virtual storefront on Instacart. They will have access to the standard Instacart platform and Instacart + memberships with a $5 per week to cover service and delivery fees and coverage of delivery tips for 3 months.
Total knee arthroplasty (TKA) is the standard of care to manage the pain and disability associated with end-stage knee osteoarthritis, with more than 700,000 TKA surgeries performed annually in the United States. Knee stiffness, commonly caused by arthrofibrosis, is an infrequent, but debilitating complication of TKA, with an incidence upwards of 5% postoperatively. As a predominant failure mechanism, knee stiffness accounts for 28% of hospital readmissions due to surgical complications within 90 days of discharge, and 10% of all revisions within 5 years of initial surgery within the United States. With the incidence of TKA projected to reach 3.5 million by 2030, the growing cohort of TKA patients with postoperative knee stiffness provides an important target for research.

Several treatments for knee stiffness have been described including static progressive splinting and manipulation under anesthesia (MUA). To date, no studies have compared the use of static progressive splinting in the early management of individuals presenting with knee stiffness after TKA to more commonly utilized surgical procedures such as MUA. Witvrouw and colleagues compared a computer-controlled passive motion device to MUA for individuals with knee stiffness after TKA and found that stretching device had similar outcomes to MUA in terms of range of motion (ROM) and self-reported pain, stiffness and function. A key limitation of this study is that the computer-controlled motion device is not commercially available and therefore translation of this technology into practice is unlikely. However, this study does demonstrate that conservative stretching techniques may be as efficacious as costlier surgical techniques as well as may cause fewer adverse events such as quadriceps tendon rupture and fractures. Only one study to date has examined the utilization of static progressive splinting after TKA. In this study, they enrolled patients who had already failed MUA and conservative physical therapy management strategies. They found that the average ROM increase for patients was 25° as well as 92% of patients were satisfied with the results and no complications occurred with use of the device. Key limitations to this study are the lack of a comparison group as well as static progressive splinting was utilized after MUA had already failed. It is unknown how individuals would respond to this treatment compared to MUA.

Therefore, the purpose of our study is to determine the feasibility and initial efficacy of static progressive splinting for individuals presenting with knee stiffness following TKA within the current surgical practice of Dr. Jared Foran at Panorama Orthopedics \& Spine Center. Data from this trial will be utilized in a NIH grant application for a larger randomized controlled trial directly comparing static progressive splinting to MUA which is the current standard of care for knee stiffness after TKA.
In the CONTROL group, the administration of fluid (250-500ml crystalloids or colloids) and cardiovascular supportive drugs will be guided to maintain standard pressure-related parameters within a normal range: MAP \> 65mmHg, HR \< 90/min, CVP \>8-12\< cm H20, urinary output \> 0.5 ml/kg/h. In line with the conventional approach, other physiological parameters will also be targeted: T° \> 35.5°C, Sp02 \> 95%, lactate \< 2.5 mmol/L, normalisation of the BE. The maximal infused volume of hydroxyethyl starch (Voluven®) will be 33 ml/kg.
1. Technical Result Increase in treatment efficiency, storage term, improvement of organoleptic properties and widening of medicinal means assortment. 2. Essence A means for treatment of gastric and duodenal ulcer contains: Hipericum perforatum L., Achillea millefolium L., fruits of Ainus barbata and Sambucus nigra L., sugar and spirit. 3. Field of Application Medicine.
As part of medical care subjects will be undergoing an endoscopic procedure (ERCP) in order to evaluate and stent a bile duct blockage. During the ECRP and just prior to the stent placement subjects will undergo the placement of a radiofrequency ablation catheter into the bile duct blockage. Heat will be applied to the bile duct in order to open the blockage and prevent the re-growth of tissue into the stent; after the radiofrequency ablation, stent will be placed. Three days after the procedure subjects will receive a phone call from the research coordinator to check any adverse or unwanted effects of the treatment. The study procedure (radiofrequency ablation) takes place over 10 minutes during ERCP. The subjects will undergo routine follow up for their medical problems. No follow up visits are required as part of the study.
Serratiopeptidase is a bacterial metalloprotease used in a variety of medical applications. The multidimensional properties of serratiopeptidase make it noticeable as a miraculous enzyme. Anti-coagulant, anti-inflammatory and anti-biofilm activity of serratiopeptidase making it useful in reducing pain and swelling associated with various conditions including arthritis, diabetes, cancer, swelling, pain and also thrombolytic disorders. It breaks down fibrin, thins the fluids formed during inflammation and due to its anti-biofilm activity, can be used in the combination of antibiotics to reduce development of antibiotic resistance. However, some drawbacks like sensitivity to environmental conditions and low penetration into cells due to its large size have limited its usage as a potent pharmaceutical agent. To overcome such limitations, improved versions of the enzyme were introduced using protein engineering in our previous studies. Novel functional serratiopeptidases with shorter length and higher stability have seemingly created a hope for using this enzyme as a more effective therapeutic enzyme. This review explains the structural properties and functional aspects of serratiopeptidase, its main characteristics and properties, pre-clinical and clinical applications of the enzyme, improved qualities of the modified forms, different formulations of the enzyme, and the potential future developments.
Osteoarthritis is one of the commonest diseases in the world, with a global disease burden of 83%. Plain radiograph remained the main modality in diagnosing osteoarthritis. Chondrogen is a mesenchymal stem cell-derived from umbilical cord tissue product. The mesenchymal stem cell is used for the study because of its ability to proliferate and differentiate into various tissues such as chondrocytes, adipocytes, and osteocytes. Various clinical studies have been conducted for arthritis, orthopedic, joint, and cartilage.

This study will enroll 100 patients age 30-70 years old. They will be divided into 2 groups which are the group which will receive the investigational drug (ChondrogenTM and HA) and another group will receive a placebo (saline and HA). It will be a randomized double-blinded study where the participants and the investigator would not know what are the things being received. This study will be conducted for 24 months. The injection will be given on the baseline day after screening the volunteers. The patients will be assessed on VAS, WOMAC, IKDC, KOOS PROMIS29, the interleukins, and MRI.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely - to gynecology, balneology, physiotherapy. Method includes taking baths and performing gynecological irrigations. Bath with mineral water from thermal radon springs, with natural water temperature about 38C (radon water) is taken two days running, with the following one-day break. First procedure lasts 5 minutes, second - 8 minutes, third - 10 minutes, the following procedures being all 15 minutes long. The course includes 10 baths. In the first part of the day, two hours after breakfast, patient drinks 200 ml of radon water in swallows at a measured pace. After taking bath procedure is carried out according to the programme of resonance-acoustic fluctuations (PRAF), gynecological irrigations with radon water for 10-12-15 minutes and detensor-therapy are carried out. In the second part of the day, two hours after dinner, patient drinks 200 ml of radon water in swallows at a measured pace. On days when bath is not taken, intestinal lavage is performed in the first part of the day, and in the second part of the day hirudotherapy is performed. Hirudotherapy is performed on the 3 day - in zone of sacrum: the top of coccyx, area of sacrum projection. On the 6 day hirudotherapy is performed in the point on medium line, immediately above pubic bone and 1 and 4 centimetres outwards. On the 9 and 12 days hirudotherapy is performed intravaginally: in points of cervix, right or left fornicis. ^ EFFECT: method improves reproductive function due to positive impact on impaired metabolic, hormonal processes and psychoemotional state. ^ 3 cl, 3 tbl
A 2.8 W, 980 nm diode laser(Sirona Advanced) in continuous wave mode with an air cooling handpiece was used in the alternative frenectomy technique. The frenulum was held with a hemostat, and a repeated continuous wave mode was applied for the excision. It was also used to remove the periosteal adhesion. The remnants of the ablated tissue were removed with saline, and no sutures were placed after the diode laser treatment.
Participants who meet the eligibility criteria will be randomized and will receive first the experimental product Turmipure GOLD® during the first study phase and then the placebo control during the second study phase. Both study phases are separated by a washout period of minimum 14 days.
For patients with 1 URD: donor KIR genotyping will be performed on the donor. Because donor selection will not depend on KIR/HLA genotyping, completion of donor KIR genotyping is not required prior to transplant.
PROBLEM TO BE SOLVED: To obtain the subject molding material comprising an acrylic copolymer of a specific composition, insoluble in gastric juice and acidic digestive juice and soluble in intestinal juice, capable of being processed in a thermoplastic state without being decomposed. SOLUTION: The molding material comprises a copolymer composed of (A) 16-40 wt.% of acrylic acid/or methacrylic acid, (B) 30-80 wt.% of methyl acrylate and (C) 0-40 wt.% of an alkyl ester [preferably ethyl (meth)acrylate, butyl (meth)acarylate, etc.] except the component B of methyl acrylate and/or methacrylic acid and optionally a common auxiliary (e.g. a plasticizer such as citric ester and a mold release agent such as stearic acid) for coating a medicine. The material has preferably 1,000-100,000 melt viscosity at 120-145 deg.C melt under 1-5 Mpa. The copolymer is obtained by emulsion polymerization in the presence of an anionic emulsifying agent in a water phase.
PROBLEM TO BE SOLVED: To enable dosing of medical powder from children to adults with a simple operation. SOLUTION: A separation distance L1 between spray ports 20A of medical powder spray nozzle parts 20 is set at 12-25mm to allow proper insertion of spray ports 20A into nasal cavities of patients in a wide range from infants to adults. As the flow of the medical powder is shunted at a branch part 18 to be supplied to medical powder paths 19, the medical powder can be dosed simultaneously and evenly into right and left nasal cavity. Moreover, the capacity of a capsule is set at 0.1-1.4cc to allow thoroughly spraying of all of the medical powder in the capsule. As the passing sectional area of an air supply path 11 is set at 0.2-6.0mm<2> , air from a pump 13 can be supplied at a proper flow rate and at an appropriate flow velocity.  On the other hand, a manual type pump 13 with a delivery capacity of 10-60cc is mounted on an air supply part 6, thereby facilitating the supply of an air flow.