anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The metabolic syndrome is a serious health condition that affects about 35 percent of adults and places them at higher risk of cardiovascular disease, diabetes, stroke and diseases related to fatty buildups in artery walls. The underlying causes of metabolic syndrome are obesity, being overweight, physical inactivity and genetic factors. In recent decades, the prevalence has increased dramatically in the United States. Lifestyle interventions including dietary modification, physical activity and weight loss form the basis of treatment for these patients. However, research has shown that even when people are able to incorporate these changes, they often revert back to their usual lifestyle resulting in weight gain and continued risk for diabetes and heart disease.

Resveratrol, a natural plant derived compound found in grapes, peanuts and red wine, has been found to reverse some of the features of the metabolic syndrome (insulin resistance, high triglycerides, high blood pressure) in rodents. These improvements occurred without weight loss, and were proven to be a direct result of resveratrol ingestion. Other studies reveal improvement in cardiovascular health, tumor suppression, and longevity. However, there are few studies investigating these beneficial effects in humans. In a systematic review of resveratrol research, the authors conclude that "in contrast to the lacking data of resveratrol in humans, the animal data are promising and indicate the need for further human clinical trials." Of the small clinical studies that have been done, the results are encouraging. Improvement in triglycerides, blood pressure and insulin resistance were noted. Resveratrol was well tolerated without serious side effects. These studies, however, did not recruit subjects with the metabolic syndrome, nor were they tightly controlled.

The investigators propose to prove that resveratrol, administered to subjects with the metabolic syndrome, under controlled conditions of weight stability, common diet, and strict compliance with the study drug, will improve the symptoms of the metabolic syndrome, thereby decreasing the chance of developing diabetes or heart disease.
Of the 150 participants in this study, half of them will be assigned to the sham treatment group. Because this is a double-blind study, it is unknown which members will be assigned to this group until the completion of the study.
The present invention belongs to the technical fields of traditional Chinese medicine health food and a manufacturing method thereof. The present invention uses modern traditional Chinese medicine theory as reference, absorbs and organically combines the viewpoints of motherland traditional medicine, modern medicine and nutrition and makes a prescription by combining dietotherapeutic medicinal materials and nutrition intensifying agent. The present invention is an eye heath care drink made by adopting six kinds of dietotherapeutic medicinal materials comprising Chinese wolfberries, chrysanthemums, cassia tora, mulberry leaves, hawthorns and black plums, adding the nutrition intensifying agent and corrective agent of zinc, vitamin C, taurine, etc. and combining the modern pharmacy production technology. The present invention achieves the goals of improving the physiological function of a human body and improving eye and vision function by replenishing nutrient components for the whole body, particularly enhancing the eye tissue nutrition. The present invention has the health care functions of nourishing liver and kidney, clearing liver-fire, improving eyesight, strengthening physique and recovering vision and achieves the effects of improving eyesight and improving vision. The present invention has an important characteristic of combing the dietotherapeutic medicinal materials having the function of improving eyesight with minerals and drinks and achieves the goals of preventing sunstroke, satisfying thirst, improving eyesight and treating eye diseases. The drink is sweet and delicious and can promote fluid production, quench thirst, dredge blood vessels, remove liver heat, enrich kidney essence, strengthen brain and build body after drunk for a long time.
This study investigates the impact of maternal nutrition during lactation on inflammation and oxidative stress in the offspring of diet-induced obese rats, along with the potential benefits of leptin supplementation during suckling. Dams were fed either a standard diet (SD), a western diet (WD) before and during gestation and lactation (WD-dams), or a WD switched to an SD during lactation (Rev-dams). Offspring were supplemented with leptin or vehicle during suckling and then fed an SD or WD until four months. Offspring of the Rev-dams exhibited improved metabolic indicators, including lower body weight, reduced plasma levels of TNF-alpha, a higher adiponectin/leptin (A/L) ratio, enhanced liver antioxidant defenses, and decreased inflammation markers in white adipose tissue (WAT) compared to WD-dams, with sex differences. Leptin supplementation further modulated these markers, reducing oxidative stress in liver and inflammation in WAT and liver (e.g., hepatic Tnfa expression decreased by 45% (males) and 41% (females) in the WD group on an SD), and improving the A/L ratio, with effects varying by maternal conditions and sex. In conclusion, this study underscores the importance of maternal nutrition and leptin intake during suckling in shaping long-term metabolic and inflammatory health in offspring, offering strategies to mitigate the adverse effects of maternal obesity on future generations.
The present invention relates to a functional nourishment food -lvyuantong capsule, which can improve intestinal function. The capsule is prepared from raw materials mainly including gen-seng, bunge cherry seed, tuckahoe, cassia seed, radish seed, black sesame, linseed, wild yam, liquorice etc. by extracting with modern technology, processing, drying and crushing, stirring well, filling into capsule and sterilizing. The lvyuantongrui capsule gives a full play in synergistic effect of medicine-food homology, and can improve gastrointestinal immune function, repair mucosal injury, enhance colorectal automaticity peristalsis, promote producing intestinal bleeding water, lubricate and relief of constipation. A functionality experiment proves: the obvious moistening intestines and relieving constipation effect is realized if takes right amount lvyuanruntong capsule as required, and easy defecation without pain. The capsule is suitable for long-term constipation and difficult defecation patients without any toxic side effect. The capsule has advantages as follows: (1) pure Chinese traditional medicine preparation; (2) without any side effect and long-term intake; (3) outstanding effect; (4) convenient in use; (5) convenient to storing, keeping and carrying; (6) defaecation without diarrhea and deficiency, proper supplyment, and obvious ejecting poison effect.
OBJECTIVE: Acute bronchiolitis (AB) is one of the most common respiratory diseases in early childhood and is still an important health problem worldwide. The systemic immune-inflammatory index (SII) is thought to have potential to be a new-generation inflammatory biomarker. We sought to investigate the value of SII for severity assessment in children with AB.
METHODS: A total of 74 AB patients were included in a prospective observational study. Patients were classified into 3 AB groups according to this classification: mild (1-5 points), moderate (6-10 points), and severe (11-12 points). Complete blood count, C-reactive protein, and procalcitonin tests were carried out. Modified Tal score was evaluated to determine severity. The performance of parameters to predict the severity of AB was assessed using the receiver operating characteristic (ROC).
RESULTS: Whereas neutrophil count (P = .037), neutrophil-to-lymphocyte ratio (P = .030), and SII (P = .030) values increased significantly with disease severity, red cell distribution width (P = .048) values were higher in the moderate AB group. The SII was found to have the highest area under the curve in the comparison of the mild-moderate groups combination and the high group on ROC analysis (P = .009).
CONCLUSION: The SII values of pediatric patients hospitalized with the diagnosis of AB were significantly higher in the high-severity group. The SII may offer additional severity stratification in children with AB.
PURPOSE: Transgenic animals expressing androgen receptor complex-associated protein are provided, which animals serve as models for developing drugs to treat cancer, e.g., liver cancer. CONSTITUTION: A substantially pure polypeptide comprises an amino acid sequence at least 70% identical to SEQ ID NO:3, or the amino acid sequence of SEQ ID NO:3, with up to 30 conservative amino acid substitutions, or is encoded by a nucleic acid that hybridizes under stringent conditions to a probe, the sequence of which is SEQ ID NO:2, wherein the polypeptide binds to an androgen receptor and increases the ability of the androgen receptor to transactivate an androgen-responsive gene. An isolated nucleic acid encoding the polypeptide having the amino acid sequence is SEQ ID NO:3 is provided. A vector comprising the isolated nucleic acid encoding the polypeptide having the amino acid sequence is SEQ ID NO:3 is provided. A cell comprising the isolated nucleic acid encoding the polypeptide having the amino acid sequence is SEQ ID NO:3 is provided. The transgenic animal whose genome comprises a transgene containing the nucleic acid encoding the polypeptide having the amino acid sequence is SEQ ID NO:3 is provided, wherein the transgenic animal exhibits an increased androgen response as compared to a wild-type animal, wherein the transgenic animal is rodent or mouse.
BACKGROUND AND OBJECTIVES: Although most spontaneous intracerebral hemorrhages (ICHs) are due to cerebral small vessel diseases (SVDs), between 1 in 7 and 1 in 10 are due to a macrovascular cause. Rapid diagnosis has important therapeutic and prognostic implications but sometimes requires digital subtraction angiography (DSA), an invasive procedure which cannot be performed in all patients. MRI provides optimal sensitivity for markers of SVD but was not included in previous risk stratification scores. We aimed to create and validate a risk stratification score for macrovascular causes of ICH including MRI findings to guide diagnosis and further investigations.
METHODS: We pooled data from 2 large observational study cohorts (London/United Kingdom and Graz/Austria) of consecutive patients with ICH who had brain MRI and at least 1 angiographic modality within 90 days of symptom onset. The primary outcome was a macrovascular cause of ICH (arteriovenous malformation/dural arteriovenous fistula, aneurysm, cavernoma, or cerebral venous thrombosis), with the diagnosis based on neurovascular multidisciplinary meetings. Using lasso logistic regression, we built the MRI Assessment of the Causes of intRacerebral haemOrrhage (MACRO) score to assess the probability of a macrovascular cause. We performed internal validation using bootstrapping and external validation in an independent cohort (Bern/Switzerland).
RESULTS: We included 1,043 patients with ICH (mean age 66 years, 42% female), 78 of whom had a macrovascular cause (7.5%). The final score includes age (0-39, 40-69, or ≥70), location of ICH (lobar, deep, or infratentorial), and SVD markers on MRI (≥1 microbleed, ≥1 lacune, presence of cortical superficial siderosis, or white matter hyperintensities using the Fazekas scale). The MACRO score showed an optimism-adjusted c-statistic of 0.90 (95% CI 0.88-0.93), superior to existing CT-based scores (p < 0.001). In external validation, the c-statistic was 0.87 (95% CI 0.80-0.94). MACRO scores ≥6 (59.5% of patients) indicated a very low risk of a macrovascular cause (0.2%), while scores ≤2 (9% of patients) indicated a high risk (48.9%).
DISCUSSION: The MRI-based MACRO score shows excellent performance in predicting the likelihood of macrovascular causes of spontaneous intracerebral hemorrhage, making it useful in guiding further investigations. Important limitations include the observational study design and the performance of DSA in a minority of patients.
FIELD: production of medicinal preparation. SUBSTANCE: method involves extraction of milled lung tissue of cattle with aqueous-saline solution in alkaline medium. Separated pulp is extracted with 2.3-2.5M solution of sodium chloride at pH 9.0-9.2, at 40-80 C, at phase ratio 1:(1.4-1.7). Prepared extract is used for preparing extractant of milled cattle lung. Method ensures to increase the yield of heparin by 20-25% and to isolate chondroitin sulfate additionally. EFFECT: improved method of heparin production.
BACKGROUND: Elevated body mass index (BMI) has been recognized as an important contributor to corticosteroid insensitivity in chronic rhinosinusitis with nasal polyps (CRSwNP). We aimed to delineate the effects of elevated BMI on immunological endotype and recurrence in CRSwNP individuals.
METHODOLOGY: A total of 325 patients with CRSwNP undergoing FESS were recruited and stratified by BMI. H&E staining was employed for histological evaluation. Characteristics of inflammatory patterns were identified by immunohistochemical staining. The predictive factors for recurrence were determined and evaluated by multivariable logistic regression analysis and the receiver operating characteristic (ROC) curves across all subjects and by weight group.
RESULTS: In all patients with CRSwNP, 26.15% subjects were classified as overweight/obese group across BMI categories and exhibited a higher symptom burden. The upregulated eosinophil/neutrophil-dominant cellular endotype and amplified type 2/ type 3 coexisting inflammation was present in overweight/obese compared to underweight/normal weight controls. Additionally, a higher recurrent proportion was shown in overweight/obese patients than that in underweight/normal weight cohorts. Multivariable logistic regression analysis identified BMI as an independent predictor for recurrence. The predictive capacity of each conventional parameter (tissue eosinophil and CLCs count, and blood eosinophil percentage) alone or in combination was poor in overweight/obese subjects.
CONCLUSIONS: Overweight/obese CRSwNP stands for a unique phenotype and endotype. Conventional parameters predicting recurrence are compromised in overweight/obese CRSwNP, and there is an urgent need for novel biomarkers that predict recurrence for these patients.
Vitamin D3 (VD3) is an essential nutrient for fish and participates in a variety of physiological activities. Notably, both insufficient and excessive supplementation of VD3 severely impede fish growth, and the requirements of VD3 for fish vary considerably in different species and growth periods. The present study aimed to evaluate the appropriate requirements of VD3 for juvenile grass carp (Ctenopharyngodon idella) according to growth performance and disease prevention capacity. In this study, diets containing six supplemental levels of VD3 (0, 300, 600, 1200, 2400, and 4800 IU/kg diet) were formulated to investigate the effect(s) of VD3 on the growth performance, antioxidant enzyme activities, and antimicrobial ability in juvenile grass carp. Compared with the VD3 deficiency group (0 IU/kg), the supplementation of 300-2400 IU/kg VD3 significantly enhanced growth performance and increased antioxidant enzyme activities in the fish liver. Moreover, dietary supplementation of VD3 significantly improved the intestinal health by manipulating the composition of intestinal microbiota in juvenile grass carp. In agreement with this notion, the mortality of juvenile grass carp fed with dietary VD3 was much lower than that in VD3 deficient group upon infection with Aeromonas hydrophila. Meanwhile, dietary supplementation of 300-2400 IU/kg VD3 reduced bacterial load in the spleen and head kidney of the infected fish, and 1200 IU/kg VD3 supplementation could decrease enteritis morbidity and increase lysozyme activities in the intestine. These findings strengthened the essential role of dietary VD3 in managing fish growth and antimicrobial capacity. Additionally, based on weight gain ratio and lysozyme activities, the appropriate VD3 requirements for juvenile grass carp were estimated to be 1994.80 and 2321.80 IU/kg diet, respectively.
Participants will be assigned to the sedentary break or control condition at each lab visit. If assigned to the sedentary break condition at lab visit 1, participants will be assigned to the control condition at visit 2 (and vice versa). During the lab visit, participants will wear a heart rate monitor and ambulatory blood pressure monitor, and eat a controlled diet. Participants will have an IV inserted and blood will be drawn 11 times throughout the visit. Participants will also eat a controlled diet for two days prior to the lab visit.
Allergoid (Dermatophagoides pteronyssinus and Dermatophagoides farinae)-mannan conjugates (MM09) at 9.000 UTm/mL for sublingual immunotherapy.. The dose is 2 sprays daily applied to the sublingual mucosa for 6 months.
PROBLEM TO BE SOLVED: To achieve an effective differentiation of a sensitive skin ideal in the judgment for the selection of a cosmetic product and the prevention of skin troubles by using a specific area of corneocyte as index based on the comparison of the size of the corneocyte with the standard size of the corneocyte determined in terms of age. SOLUTION: There is a better linear relationship between two variables related to the normal corneocyte and the age and hence, the standard area of the normal corneocyte can be expressed by a function of the age. As the standard corneocyt contains season as factor, the season is incorporated as factor to allow the calculation of a correct standard area of the corneocyte. In the differentiation of a sensitive skin, the measured area of a corneocyte of an examinee is compared with the standard area of the corneocyte calculated as base. When the area of the examinee is almost the same as the standard area of the corneocyte, ordinary skin is presented. When the measured area of the corneocyte is smaller than the standard area thereof, sensitive skin is determined.
PURPOSE: Sexually transmitted infections (STIs) represent an enormous public health burden in the United States. Emergency departments (EDs) are a significant source of medical care, particularly for vulnerable patient populations. Guidelines for the treatment of Chlamydia trachomatis have evolved and now recommend doxycycline 100 mg orally twice daily for 7 days as the primary regimen for adults. However, the single-dose azithromycin regimen can be given during the ED visit, while the new regimen has nonadherence hurdles. The purpose of this study will be determining the rate of ED discharge prescription pick ups of doxycycline for Chlamydia trachomatis infection at two discharge pharmacies.
METHODS: This is a retrospective chart review of information contained in the electronic medical record (EMR) from August 1st, 2021 - July 31st, 2022. Adult patients who present to the two EDs in the healthcare system and those who received empiric antibiotic treatment for Chlamydia trachomatis infection prior to, or at, ED discharge will be included. Patients who are pregnant, less than 18 years old, those without a Chlamydia trachomatis nucleic acid amplification test during their ED visit, or patients whose antibiotic treatment prescription was sent to a pharmacy other than the two primary discharge pharmacies at the respective medical centers will be excluded. The primary outcome of this study will be determining the rate of emergency department (ED) discharge prescription pick ups of doxycycline for empiric treatment of Chlamydia trachomatis infection at two discharge pharmacies. The secondary outcomes will include the incidence of repeat positive tests between four weeks and 90 days, risk of repeat positive tests in those who do not fill doxycycline, number of positive and negative test results, rate of prescribing adherence to 2021 Centers for Disease Control and Prevention (CDC) Sexually Transmitted Infections Treatment Guidelines regimens for empiric treatment, and insurance status at the time of discharge fill.
RESULTS: Seven hundred and thirty patients were pulled from the EMR. One hundred of the patients were excluded from the study as they did not receive empiric antibiotic treatment for Chlamydia trachomatis infection prior to, or at, ED discharge leaving 630 participants. Among this group, 369 patients were excluded as their discharge prescription was not sent to the discharge pharmacies within the medical system, leaving 261 individuals in the study. Per chart review, 215 of the patients picked up their doxycycline prescription (82.4%) and 46 (17.6%) patients failed to pick up their prescription. Additionally, 43 (16.5) of the patients who were prescribed empiric therapy had a positive chlamydia trachomatis test, while 209 (83.5%) of those had a negative test. This study also showed 188 (72%) patients received treatment according to the current CDC recommendations.
CONCLUSION: Majority of patients who received prescriptions from the in-hospital discharge pharmacy picked up their prescriptions.
PROBLEM TO BE SOLVED: To obtain the subject medicine effective by a small amount use, further having small side effect and useful as thrombus inhibitor by making the medicine include peptide derivatives derived from lactoferrin as an active ingredient. SOLUTION: The subject medicine includes peptide derivatives of the formulas R1 -X, X-R2 or R1 -X-R2 (R1 is acyl or polyethylene glycol; R2 is amino or acyl, etc.; X is anyone selected from among peptides of formulas I, II, III, etc., comprising amino acid residues of D-form or L-form), a salt thereof, a bound material of the peptide bound with a carrier, an adsorbed material of the peptide derivative adsorbed on the carrier, or a mixture thereof as an active ingredient. The salt of the peptide derivative is preferably a hydrochloride, citrate, etc. The carrier is preferably a starch, a dextrin, etc. The peptide derivative is obtained by adding acyl, polyethylene glycol, etc., by an organic synthesis technique to a polypeptide, for example, synthesized by a well-known method.
FIELD: conservation of microorganisms or enzymes. SUBSTANCE: processed thrombocytes adhere to thrombogenic surfaces and do not adhere to non-thrombogenic surfaces. They swell as they adhere to thrombogenic surfaces, and they adhere to one another to form a hemostatic plug in adhering to thrombogenic surfaces and releasing their granular contents. Also described are pharmaceutical compositions containing such thrombocytes. Preferably, the thrombocytes are fixed with a fixing agent such as formaldehyde, paraformaldehyde, glutaric aldehyde, or some permanganate. Preferably, they are dried by lyophilic drying. EFFECT: higher quality.