anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVE: Asymmetric sensorineural hearing loss (ASHL) is the most common symptom of sporadic vestibular schwannoma (VS). However, there is still no universally accepted MRI protocol for diagnosing VS. This study identified the characteristics of pure tone audiogram (PTA) in patients with VS.
METHODS: We conducted a retrospective chart review of patients diagnosed with sporadic unilateral VS. In the analysis, we focused on the shape and interaural differences of PTA, stratified by the mode of onset and patient age.
RESULTS: In total, 390 patients met the inclusion criteria. The U-shaped audiogram showed the highest proportion in patients with the onset of sudden sensorineural hearing loss (SSNHL). In patients with SSNHL, U-shaped audiograms were younger than other audiograms, and 86.7 % of patients under 40 had U-shaped audiograms. Patients with VS were more likely to have interaural differences at higher frequencies than at lower frequencies. Patients with SSNHL had a significantly higher percentage of interaural differences at 500-4000 Hz than those with onset other than SSNHL (non-SSNHL patients). In addition, non-SSNHL patients had a significant trend toward a higher percentage of interaural differences at all frequencies with increasing age.
CONCLUSION: MRI screening can be considered in patients with SSNHL with U-shaped audiograms under 40 years of age. In ASHL, not SSNHL, MRI screening can be considered for older patients with interaural differences at wider continuous frequencies. Patients with interaural differences at high frequencies had a higher priority than those with interaural differences at low frequencies as indications for MRI screening for VS.
PCT No. PCT/JP96/01570 Sec. 371 Date Nov. 24, 1997 Sec. 102(e) Date Nov. 24, 1997 PCT Filed Jun. 10, 1996 PCT Pub. No. WO97/35875 PCT Pub. Date Oct. 2, 1997The present invention relates to a peptide having an amino acid sequence of Val-Val-Tyr-Pro as well as an agent for inhibiting elevation of triglyceride levels in blood, a food for specified health use (the so-called physiologically functional food) and a feed comprising the above peptide as an active component. According to the present invention, a peptide inhibiting elevation of triglyceride levels in blood as well as an agent for inhibiting elevation of triglyceride levels in blood, a physiologically functional food and a feed, all comprising the peptide as an active component are obtained. With these products of the invention, it becomes possible to prevent or treat obesity and hyperlipemia of human and animals as well as circulatory system diseases such as hypertension and arteriosclerosis associated therewith. Furthermore, the materials of the invention make it possible to improve the meat quality of livestock and hatchery fish.
The COVID-19 pandemic has altered the epidemiology of many common childhood infections, including Group A streptococcal (GAS) disease. Acute post-streptococcal glomerulonephritis (APSGN) is a nonsuppurative complication of GAS pharyngitis and pyoderma. It remains the most common cause of pediatric acute glomerulonephritis globally. In Counties Manukau, New Zealand, APSGN rates have previously been shown to be the highest in the country, with marked ethnic and socioeconomic disparities. We performed a retrospective review of children aged 0-14 years who were discharged from Kidz First Hospital, Counties Manukau, between 2015 and 2023 and met the Strep A Vaccine Global Consortium consensus definition of APSGN. We describe a marked, sustained reduction in APSGN hospitalizations, temporally associated with the COVID-19 pandemic. This ongoing reduction in APSGN incidence is notable in light of contrasting reports of increasing incidence of rheumatic fever in New Zealand and invasive GAS disease internationally.
At the onset of an attack, one metered spray or two metered sprays should be administered on or under the tongue. A spray may be repeated approximately every 5 minutes as needed. If two sprays are used initially, the patient may only administer one more spray after waiting 5 minutes. No more than 3 metered sprays are recommended within a 15-minute period. If chest pain persists after a total of 3 sprays, prompt medical attention is recommended. Nitroglycerin Lingual Aerosol may be used prophylactically 5 minutes to 10 minutes before engaging in activities that might precipitate an acute attack.
The study will take approximately 2-3 months to complete. First, you will be screened to see if you are eligible for the study. At this visit the male partner will give a medical history and be asked to donate a semen sample for analysis, while the female will give a medical history, receive a physical exam, pelvic exam, pregnancy test, and will be tested for vaginal infection including Gonorrhea/Chlamydia. If you are eligible (as a couple), you will be called and randomized into one of four study groups. You will be allowed to choose whether you want to take certain samples yourself at home, or have them all taken by a nurse at the clinic. At this point you will either be asked to return home to have sexual intercourse, or the male partner will be asked to donate a semen sample, which will then be inserted into the female's vagina. Depending on which group you are in, you will next be asked to return to the clinic either 4 or 7 times over the next 2 weeks for vaginal swabs.

Once you complete the main study, you will be offered the opportunity to participate in a substudy, where you will repeat the same visits, except that if you chose to have all your samples taken in the clinic for the main study, you will take certain samples at home for the substudy. If you chose to take certain samples at home for the main study, you will have all the samples taken at the clinic for the substudy. Also, you will not need to do another screening visit if you start the substudy within 9 weeks of the end of the main study.
FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to novel compounds of the formula (1) α where   and R 1  mean hydrogen atom; or R 2  and R 1  are bound each with other and in common with represented carbon atoms to which they are bound mean o-phenylene or o-naphthylene that can be substituted; R 2  means substituted phenyl; R 3  means hydrogen atom, alkyl, phenyl or benzyl; R 4  means hydrogen atom or alkyl; R 4  means R 5 , -CH 2 - -CO-, -CO-; n means 1, 2 or 2. Compounds are synthesized by addition reaction of acid salts of indicated compounds that comprise nitrogen atom that is able to be protonized. Indicated compounds exhibit inhibitory activity for reduction of undesirable levels of metalloproteinases and inhibitory activity for reduction of TNF -CH 2 - levels. Owing to these properties they can be used as active compound in pharmaceutical compositions and in methods for reduction of undesirable levels of TNF α and for inhibition of undesirable levels of metalloproteinases. EFFECT: improved method of synthesis, valuable medicinal and biochemical properties of compounds. 15 cl, 2 tbl, 41 ex
The present invention relates to antibodies, in particular humanized antibodies, against hepatitis b surface antigen (HBsAg), nucleic acid molecules encoding them, methods for preparing them, and pharmaceutical compositions comprising them. The anti-HBsAg antibody of the present invention has higher affinity for binding HBsAg at neutral pH than at acidic pH, thereby significantly enhancing virus clearance efficiency and prolonging virus inhibition time. The antibodies and pharmaceutical compositions of the invention are useful for preventing and/or treating HBV infection or a disease associated with HBV infection (e.g. hepatitis b), for neutralizing the virulence of HBV in a subject (e.g. a human), for reducing the serum level of HBV DNA and/or HBsAg in a subject, or for activating the humoral immune response against HBV in a subject (e.g. a chronic HBV infected or chronic hepatitis b patient).
BACKGROUND: Biliary atresia (BA) is a progressive disease affecting the bile duct structure and function, leading to poor outcomes without timely surgical intervention. Kasai portoenterostomy (KPE) is a commonly used treatment to restore bile flow. However, the success rate and postoperative outcomes of KPE vary with different surgical techniques, including laparoscopic, robot-assisted, and open approaches.
METHODS: Following the PRISMA guidelines, this study systematically searched PubMed, EMBASE, and Cochrane databases for literature on BA surgical techniques of KPE. Studies comparing two or all three techniques-laparoscopic, robot-assisted, and open-in terms of postoperative outcomes of KPE in BA patients were included. Utilizing the "gemtc" package in R version 4.3.3, NMA was conducted to compare postoperative clearance of jaundice (COJ) among different surgical techniques. We also performed traditional paired meta-analysis in which multiple surgical outcomes were compared.
RESULTS: According to the traditional definition of a successful KPE surgery, in terms of successful postoperative COJ, robotic-assisted Kasai portoenterostomy (RAKPE) shows advantage over open Kasai portoenterostomy (OKPE) and laparoscopic Kasai portoenterostomy (LKPE), while the outcomes between OKPE and LKPE are equivalent. However, statistically speaking, there is no significant difference among the three techniques. LKPE has a longer operation time and less intraoperative bleeding compared to OKPE. There are no statistically significant differences in hospital stay, cholangitis incidence, or liver survival rates at 6 months, 1 year, 2 years, or 5 years.
CONCLUSION: The surgical success rates of KPE with various technical aids are similar, highlighting the need to consider individual patient conditions and cost when choosing a surgical technique. Effective postoperative management is vital for preventing complications and slowing liver fibrosis. Future research should focus on improving surgical techniques and postoperative care to enhance long-term outcomes for BA patients. For those who cannot maintain liver function with KPE, timely LT consideration is crucial.
Participants will receive initial starting dose of Niraparib 200 milligram (mg) once daily in combination either with Apalutamide 240 mg (4\*60 mg) once daily or Abiraterone Acetate 1000 mg (4\*250 mg) plus 10 mg Prednisone (5 mg twice daily) for 28 days of cycle 1. Once a safe dose of niraparib is selected with each Andrgen Receptor (AR)-targeted therapy \[Apalutamide or Abiraterone Acetate plus Prednisone\], then an expansion phase (Part 2) will open to further explore safety and assess antitumor activity.
A chitosan-modified ethosome structure  10  having property of targeting is provided. The chitosan-modified ethosome structure  10  includes a first liposome shell  100  and a second liposome shell  200.  The external radius of the first liposome shell  100  is smaller than the internal radius of the second liposome shell  200,  and the second liposome shell  200  encloses the first liposome shell  100.  In addition, a first space  50  is defined in the inside of the first liposome shell  100,  and a second space  150  is defined between the inside surface of the second liposome shell  200  and the outside surface of the first liposome shell  100.  A plurality of ring-shaped structures  105  is formed on the outside surface of the second liposome shell  200.  Each ring-shaped structure  105  is consisted of algae sugar and beta-cyclodextrin. The first space  50  is for containing a first active substance  300,  and the second space  150  is for containing a second active substance  400.  The chitosan-modified ethosome structure  10  contains active substances with different effects, such that improves the storage and transportation of multi-active substances.
FIELD: scaly pigments. SUBSTANCE: invention relates to scaly pigments with the modified surface based on substrate scaly particles. Scaly particles of substrate pigment were covered with titanium dioxide layer and alkaline-earth metal titanate layer exhibiting perovskite structure is applied over substrate. A method of pigment producing involves precipitation of alkaline-earth metal titanate on titanium dioxide layer localized on substrate scaly particles. Alkaline-earth metal titanate is obtained by addition of titanium water-soluble salts to suspension of substrate particles. Process is carried out by precipitation at pH = 6-12 in the presence of water-soluble 1,2-diol or hydrogen peroxide. Titanium water-soluble salt is added slowly by drops, pigment particles were separated, washed, dried and calcined at 800 C, not below. EFFECT: improved method of producing. 2 cl
PURPOSE: A radioactive iodine labeled compound of boronophenylalanine is provided to easily observe the absorption degree and movement method of boronophenylalanine on a black paper in applying the boronophenylalanine to a human body. CONSTITUTION: 50mg of boronophenylalanine is dissolved with 50 microliter of trifluoroacetic acid. 1ml of potassium of 0.2 mole is put in the dissolved solution and regulated to pH 7-8 by using sodium hydroxide. One iodo bead(Pharmacia Co.) and 20 microliter of a boronophenylalanine solution are put in a reaction container. Herein, 15/5 micro liter of potassiumiodide is added up. Then, after putting Na123I of 2mCi/20micro liter, the mixed solution is agitated and then acted at a room temperature for thirty minutes.
No reports of overdosage with VIBERZI have been reported.

In the event of acute overdose, the stomach should be emptied and adequate hydration maintained. The patient should be carefully observed and given standard supportive treatment as required. Given eluxadoline’s action at opioid receptors, administration of a narcotic mu-opioid antagonist, such as naloxone, should be considered. Considering the short half-life of naloxone, repeated administration may be necessary. In the event of naloxone administration, subjects should be monitored closely for the return of overdose symptoms, which may indicate need for repeated naloxone injection.
FIELD: medicine. SUBSTANCE: method involves modeling plate applicator device according to wound surface form, firing with open fire and placing immediately over the wound surface. In treating trophic ulcers, applicator is applied during 3-5 days with the applicator firing treatment being obligatory. Then the injured surface is placed into gnotobiological isolation ward. When indicated, the process is repeated until the full recovery is achieved. EFFECT: accelerated treatment course. 2 cl
All patients will receive IVIG (2g/kg) in 10-12 hours plus high-dose aspirin (80-100mg/kg/day, divided into four doses) till fever subside. After fever subsides, low-dose aspirin (3-5mg/kg/day) will be prescribed until 6-8 weeks.
The present invention relates to porcine reproductive and respiratory syndrome virus (PRRSV) vaccines in a field of veterinary biological products, and more particularly to a PRRSV SX-105 strain having a deposit number of CGMCC No. 9906, and a use thereof in preparing PRRSV live vaccines. PRRSV SX-1 original strains are strongly pathogenic to swine. A PRRSV SX-105 attenuated strain shows safety and good immunogenicity on the swine. The PRRSV live vaccines, prepared from the PRRSV SX-105 strain, are safe and reliable, and able to generate strong immunity after immunization. The PRRSV live vaccines significantly decrease morbidity and mortality in inoculated swine groups, and have immunization effects reaching and slightly better than conventional commercial vaccines on the market, showing advantages to compete with the same kind of products around the world. The PRRSV live vaccines are capable of effectively preventing PRRS epidemic and transmission, and has broad application prospects.
Hepatic fibrosis is a complex chronic liver disease in which both macrophages and hepatic stellate cells (HSCs) play important roles. Many studies have shown that clodronate liposomes (CLD-lipos) effectively deplete macrophages. However, no liposomes have been developed that target both HSCs and macrophages. This study aimed to evaluate the therapeutic efficacy of lipopolysaccharide-coupled clodronate liposomes (LPS-CLD-lipos) and the effects of liposomes size on hepatic fibrosis. Three rat models of hepatic fibrosis were established in vivo; diethylnitrosamine (DEN), bile duct ligation (BDL), and carbon tetrachloride (CCl4). Hematoxylin and eosin staining and serological liver function indices were used to analyze pathological liver damage. Masson's trichrome and Sirius red staining were used to evaluate the effect of liposomes on liver collagen fibers. The hydroxyproline content in liver tissues was determined. In vitro cell counting kit-8 (CCK-8) and immunofluorescence assays were used to further explore the effects of LPS modification and liposomes size on the killing of macrophages and HSCs. Both in vitro and in vivo experiments showed that 200 nm LPS-CLD-lipos significantly inhibited hepatic fibrosis and the abnormal deposition of collagen fibers in the liver and improved the related indicators of liver function. Further results showed that 200 nm LPS-CLD-lipos increased the clearance of macrophages and induced apoptosis of hepatic stellate cells, significantly. The present study demonstrated that 200 nm LPS-CLD-lipos could significantly inhibit hepatic fibrosis and improve liver function-related indices and this study may provide novel ideas and directions for hepatic fibrosis treatment.
To be comparable to EWMS, the control intervention will also be a 3-session individual intervention involving engaging in a writing exercise per session. For the control writing exercises, participants will be asked to write for 30 minutes about their daily activities since waking up that day based on Pennebaker's standard writing paradigm (Pennebaker \& Beall, 1987). Individuals in the control condition will also be given information about the purpose of the writing exercises to be comparable to the psychoeducation information provided in EWMS. Similar to EWMS, the clinician will check in with the participant about the writing session, such as asking how the session went and how it felt to do the writing, following the 30 minutes of writing.
Subjects will be given manipulation under anesthesia, will fill out questionnaires about their knee and quality of life and will be followed throughout their routine follow up to assess their continued process. Subjects will fill out questionnaires at the time of their consent and their 6-week and 1-year follow up visits. The questionnaires will take about 15-20 minutes to complete.
PURPOSE:To easily obtain the correspondence of image information with subordinate information by providing a card image reader, reading the subordinate information described on an ID card, and obtaining an image signal. CONSTITUTION:When X-ray film 6 is carried in a direction of Y and it arrives at a position sandwiched between a lamp 7 and a line sensor 8, light emitted from the lamp 7 is modulated by an X-ray image recorded on the film 6 and transmits it. When the film 6 is carried in the direction of Y repeatedly, an analog signal SA in accordance with the entire plane of the X-ray image recorded on the film 6 can be obtained. The signal SA is converted into a digital image signal by an A/D converter 11. The signal is sent to an optical disk device as being conformed to a processing date, a number, and the subordinate information as the image information inputted from the card image reader mutually, and is stored in an optical disk 12. Thereby, it is possible to easily obtain the correspondence of the image information with the subordinate information, and to obtain the image information by reading the subordinate information.
Participants in the experimental group will engage in a 10-week free weight resistance training program. This program will consist of 3 weekly sessions, including exercises such as squats, deadlifts, and bench presses, among others. The training will focus on progressively increasing the intensity, working within a range of 60% to 80% of the one-repetition maximum (1RM).
The invention discloses a traditional Chinese medicinal composition for treating ancylostomosis of dog and a preparation method thereof. The traditional Chinese medicinal composition for treating the ancylostomosis of dog comprises the following components calculated according to weight part: 2-4 parts of cortex meliae and 1-2 parts of betel nut. The preparation method comprises the following steps of: adding water which is 8 volumes by weight of medicinal material in 2-4 parts of the cortex meliae and 1-2 parts of the betel nut and respectively decocting for 2h and 1.5h; combining decoctions and filtering; condensing until the relative density is 1.24(70-80 DEG C); and adding sugar powder which is 50-70 percent of total amount of the medicinal material, pelletizing, drying at 70 DEG C and granulating to obtain the traditional Chinese medicinal composition. The cortex meliae in the formula is used for killing pests and treating tinea. The betel nut is used for expelling parasites and food tagnancy and promoting qi circulation to induce diuresis. The medicines are combined so as to effectively destroy and expel anchylostomes.
Case-matched historical controls will have received neoadjuvant chemotherapy with gemcitabine prior to open pancreaticoduodenectomy (PD) by the standard Whipple or pylorus-preserving approach. Adjuvant systemic chemotherapy (SCT) with gemcitabine will be administered for 6 mo (including period of neoadjuvant therapy) according to established institutional protocol.
Sepsis-induced cardiomyopathy (SIC) is described as a reversible myocardial depression that occurs in patients with septic shock. Increasing evidence shows that microRNA-194-5p (miR-194-5p) participates in the regulation of oxidative stress, mitochondrial dysfunction, and apoptosis and its expression is associated with the occurrence and progression of cardiovascular disease; however, the effects of miR-194-5p in SIC are still unclear. This study explores whether miR-194-5p could modulate SIC by affecting oxidative stress, mitochondrial function, and apoptosis. Experimental septic mice were induced by intraperitoneal injection of lipopolysaccharide (LPS) in C57BL/6J mice. The biological role of miR-194-5p in SIC in vivo was investigated using cardiac echocardiography, ELISA, western blot, qRT-PCR, transmission electron microscopy, terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, bioinformatics analysis, and dual-luciferase reporter gene assay. Our major finding is that miR-194-5p antagomir mitigates sepsis-induced cardiac dysfunction, inflammation, oxidative stress, apoptosis and mitochondrial dysfunction in the hearts of septic mice, while miR-194-5p agomir triggers the opposite effects. Furthermore, dual-specificity phosphatase 9 (DUSP9) is a direct target of miR-194-5p and the cardioprotective effects of miR-194-5p antagomir on cardiac dysfunction, inflammation, apoptosis, mitochondrial dysfunction and oxidative stress are abolished through inhibiting DUSP9. Therefore, miR-194-5p inhibition could mitigate SIC via DUSP9 in vivo and the novel miR-194-5p/DUSP9 axis might be the potential treatment targets for SIC patients.