anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
A cosmetic agent containing a cosmetically acceptable carrier; at least one non-ionic polyurethane polymer comprising at least one polyurethane compound, at least one non-ionic polyether compound and at least one ether compound; at least one emulsifier having an HLB value from 1-6; at least one emulsifier having an HLB value from 10-17; at least one sweat-inhibiting and/or deodorizing active substance; and wherein the total amount of emulsifiers in the cosmetic agent is from 0.01-4.9wt%. Preferably, the non-ionic polyurethane polymer additionally comprises at least one polyamine compound. The polyurethane polymer may be a copolymer modified terminally with lauryl alcohol and consisting of cocoaminopropylamine, polyethylene glycol and hexamethylene diisocyanate (HDI). Alternatively, the polyurethane polymer may be a copolymer modified terminally with a branched C16-C20 alcohol and consisting of trimethylhexane diisocyanate (TMHDI). Also disclosed is the use of said cosmetic agent for increasing skin compatibility and/or for reducing and/or preventing textile discolouration and/or textile stains. A non-therapeutic cosmetic method is also disclosed for reducing the perspiration of the body and/or for reducing the body odour triggered by perspiration, wherein said cosmetic agent is applied to the human skin and remains at the site of application for at least one hour.
The invention discloses a puerarin instant eye gel and a preparation method thereof. 1000ml puerarin instant eye gel of the invention contains 2g to 30g of puerarin, 0.05g to 1g of antiseptic, 1.0g to 7.5g of osmo-regulator, 30g to 150g of gel matrix and rest of buffer solution and injection water. Proved by clinical practice, the invention has advantages of perfect effect of anti-glaucoma, safe and convenient use, less side effect, eyesight protection, etc. Primary angle-closure glaucoma is one of serious nonreversible diseases causing blind. China is the high risk region for angle-closure glaucoma, the illness frequency rate thereof is fourteen times higher than that of Occident. The peripheral iridectomy is mainly used to prevent intraocular pressure elevation in early period. Preliminary experiment proves that the invention has certain curative effect on primary angle-closure glaucoma.
This is a 2-stage master protocol with multiple substudies testing investigational drugs/drug combinations in patients with CDK4/6-inhibitor resistant ER+/HER2- metastatic breast cancer. First line endocrine therapy (1LET, aromatase inhibitors; AI) improve clinical outcomes, but are not curative, and acquired resistance develops (median \~2 years). CDK4/6i-resistant MBC is a clinical unmet need, and is marked by numerous potential resistance alterations / mechanisms. Currently, most patients receive second line (2L) ET (e.g., fulvestrant) which has a median progression-free survival (PFS) of \~2 months in this setting. Circulating tumour DNA (ctDNA) and circulating tumour cells (CTCs) are detectable in peripheral blood in \>90% of patients with MBC.

Patients who wish to participate but progression has not yet occurred may be enrolled in the monitoring substudy and followed until progression. This monitoring component of IND.241 aims to characterize the molecular and clinical features of CDK4/6i resistance as it occurs after first line CDK4/6i + AI. Besides addressing the principal objectives described above (ctDNA genotyping and evaluation of dynamic changes in ctDNA and CTC levels), banked samples will create a biorepository for interrogation of emerging assays (e.g., DNA methylation, CTC protein or single cell analyses) that may have prognostic or predictive application. These data will inform future efforts that may consider intervention prior to clinical treatment failure.
An exploratory study to examine the efficacy and safety of imatinib mesylate in combination with dihydroartemisinin plus piperaquine on suppression of parasitemia in patients with uncomplicated Plasmodium falciparum malaria. In vitro studies of P. falciparum parasitized erythrocytes demonstrate that inhibitors of the protein tyrosine kinase SYK prevent malaria parasite egress from infected red blood cells and thereby terminate the parasite's life cycle. Although no potent syk kinase inhibitors were approved for human use at the time of initiation of this study, a bcr-abl tyrosine kinase inhibitor (imatinib mesylate (Gleevec®)) that also exhibits off-target inhibition of syk tyrosine kinase, has been FDA-approved for treatment of a number of human malignancies including chronic myelogenous leukemia and GIST. Because imatinib can be taken daily for many years without significant toxicity, it can be used to obtain a preliminary indication of whether inhibition of erythrocyte syk kinase can suppress parasitemia in patients with P. falciparum malaria. In a phase 1 clinical trial on the same patient population, anti-malaria activity was observed with imatinib, with little or no accompanying toxicity. Because dihydroartemisinin plus piperaquine constitute the currently used standard-of-care therapy for malaria in Southeast Asia, the above trial will test the safety and efficacy of the combination of imatinib plus dihydroartemisinin and piperaquine in treatment of uncomplicated malaria. In this pilot study, the rate of decrease in peripheral blood parasitemia in 30 adult male patients with uncomplicated malaria will be compared to the same rate of decrease in parasitemia in 30 adult male patients treated solely with dihydroartemisinin plus piperaquine.
In the past few years, the government has been focusing on community based care, the idea so-called aging-in-place. Therefore, the intervention model for residents in long-term care institution had been noticed by the researcher. Most of the residents in long-term care institution were wheelchair users, however, it would limit the participation in physical activities, and thus increase the degree of disability as they excessively rely on wheelchair. Recently, with the development of rehabilitation technology, the clients can receive more individualized physical activities intervention. Moreover, using technology as an assistive modality would reduce the demand of manpower, and provide higher treatment intensity with repeated training and objective performance feedback. Based upon our previous study finding from the physical activity with computerized upper limb training system (PACUTS), we propose to build a training strategy of physical activity for stroke wheelchair user in long-term care institution and to analyze its feasibility as well as the treatment effects, in the next two years.

The mixed method design will be applied. In the qualitative research, we will focus on the experience of physical activity training and subject's "adoption and acceptance" of the PACUTS. Through in-depth interview, field notes and different interviewers, the qualitative data analysis with phenomenology design will be applied. In terms of the quantitative research, 50 residents who currently live in long-term care institution will be recruited. Double-blinded randomized control-group pretest-posttest design will be conducted. In the experiment group, the participant will receive the intervention of PACUTS for 12 weeks/ 5 sessions per week/ 30 minutes, at least, per session. In terms of control group, the participant will receive a regular treatment program and physical activities scheduled by occupational therapist. Participants will be assessed by outcome measures, including Time Up and Go Test, Box and Block Test, Grip Strength Assessment, the Ruff 2 \& 7 Selective Attention Test, System Usability Scale, Barthel Index, SF-36 and the Falls Efficacy Scale-International. Descriptive statistics, independent-sample t test, paired-sample t test or mixed type 2-way ANOVA will be performed for data analysis. This study is expected to contribute to build a training strategy with computerized upper limb training system which can helpfully promote the participation in physical activities and health outcomes for w/c residents living in long-term care institution.
Since the laparoscopic methods have been introduced to the surgical operations, laparoscopic cholecystectomy has become the golden standard in gall bladder surgical treatments. In this method, carbon dioxide (CO2) pneumoperitoneum method is used to achieve the desired surgical and visual conditions. Alongside the advantages of the Laparoscopic cholecystectomy method (e.g. shortening the patient's length of stay at the hospital, minimal postoperative pain and rapid recovery), it has various intraabdominal pressure related systemic disadvantages . Insufflation of CO2 in abdominal cavity causes positioning of the diaphragm upwards, a decrease in lung's volume and its compliance, an increase in the airway resistance, mismatch between the atelectasis and the ventilation perfusion. Various ventilation strategies have been introduced to increase arterial oxygenation, functional residual capacity (FRC), and the lung compliance. Recent studies; demonstrates that pressure-controlled mechanical ventilation is superior to volume-controlled mechanical ventilation in providing arterial and tissue oxygenation.

Although there are numerous studies in laparoscopic surgery, only a few of them investigate the effects of laparoscopic surgery on the cardiopulmonary and the respiratory mechanics. Several experimental and clinical studies describe that the cardiovascular effects of the high intraabdominal pressure and the CO2 insufflation is complex. In fact, the results are linked to the studied patients' population, the lung's position and its volume. As it is known in laparoscopic surgeries, the oxygenation in cerebral tissue decreases as the intraabdominal pressure increases. At present, bispectral index (BIS), electroencephalography (EEG), auditory evoke potential (AEP) (and several others) and functional NIRS (fNIRS) are used to measure cerebral oxygenation and anaesthetic depth. NIRS monitorisation makes use of the combined effects of the transmission, the reflection, the dispersion, and the absorption of light. It can also measure the oxygen saturation in tissues that does not have pulsatile circulation. The investigator aimed To examine the effects of pressure-controlled and volume-controlled ventilation modes on cerebral oximetry and blood gases in laparoscopic cholecystectomy operations.
The aim of this study was to examine the effects of high-intensity plyometric training (HIPT) on some parameters in elite soccer players in the U17. Volunteer soccer players were randomly divided into two groups according to their positions: the regular training (RT) group (age: 16.71 ± 0.47 years; stature: 163.46 ± 3.31 cm; body weight: 61.04 ± 1.59 kg) and the HIPT group (age: 16.64 ± 0.50 years; stature: 165.60 ± 3.03 cm; body weight: 59.76 ± 1.92 kg), and each group included five defenders, five midfielders, and four attackers. While the RT group did only routine soccer training, the HIPT group performed high-intensity plyometric training three days a week in addition to routine soccer training. In the study, body weight, stature, sprint (10 m, 30 m, and 40 m), jump (standing long jump, right and left-limb triple hop) and 5-0-5 change of direction speed test measurements of the soccer players were taken. Skewness and Kurtosis values obtained from the pre-test and post-test measurements were calculated to test whether the normality assumption of the study was met. A mixed measure two-way ANOVA test was used to determine the difference between the pre-test and post-test. The significance was set as p < 0.05. The results indicated that 8-week high- intensity plyometric training provided more improvement in measured performance parameters than routine soccer training. As a result, when the data obtained is examined, it can be said that HIPT had better values in sprint, jump, and change of direction parameters, so plyometric training was more beneficial for anaerobic parameters than routine soccer training in children. It is recommended that the trainers make their plans considering these results.
Purpose of Study: Nurses around the world have faced challenges during the coronavirus disease 2019 (COVID-19) pandemic. This study examined the association between depression and anxiety and trait energy and trait fatigue, and baseline health status and work characteristics. Design of Study: A cross-sectional study. Methods: A survey was conducted to collect self-reported data from nurses involved in patient care in Northern Virginia. Depression and anxiety were assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS) depression and anxiety scales. To measure trait energy and trait fatigue, the Mental and Physical State and Trait Energy and Fatigue Scale (MPSTEFS) was used. Findings: There was a significant association between depression and energy (b=-0.46, t = -1.78, p < .001) and loneliness (b=1.38, t = 4.00, p < .001) and increased alcohol use (b=2.11, t = 2.04, p = .045). We also found that nurses with depression were significantly more likely to seek mental health counseling (b=-2.91, t = 2.54, p = 0.013), which was also the case for anxiety (b=3.13, t = 2.14, p = .036). Conclusions: Our study highlights the mental health burden among nurses who worked in the early phase of the COVID-19 pandemic and its association with increased alcohol use and loneliness. The findings may help healthcare leaders identify early signals of deterioration in nurses' well-being.
<P>PROBLEM TO BE SOLVED: To display a menu screen wherein display order is considered on a screen.  <P>SOLUTION: A computer 1 is made to function as a reception means 2, a disease name acquisition means 3, a display order acquisition means 4, a screen creation means 5, and a display means 6. The reception means 2 receives identification information for identifying a plurality of patients. The disease name acquisition means 3 refers to a first table 7 recording a disease name of each patient, and acquires the disease name corresponding to the identification information. The display order acquisition means 4 refers to a second table 8 recording information related to the display order of a menu item corresponding to the disease name and a third table 9 recording information related to the display order of the menu item opened in time of a medical examination by a doctor, and acquires the display order corresponding to the disease name acquired in the disease name acquisition means 3. The screen creation means 5 creates the menu screen set with the menu item based on the display order acquired in the display order acquisition means 4. The display means 6 displays the created menu screen on the screen.  <P>COPYRIGHT: (C)2010,JPO&INPIT
<P>PROBLEM TO BE SOLVED: To provide a technique for enlarging the transparent region of a bar soap without detriment to foaming properties and foam qualities.  <P>SOLUTION: The transparent bar soap comprises an ester from a polyglycerine and a linear saturated fatty acid. Preferably, the ester from the polyglycerine and the linear saturated fatty acid is one having properties of a hydrophilic surfactant, specifically one having an average polymerization degree of glycerine of 5-15 and at least 4, more preferably 8-10 free hydroxy groups. Among these, an ester having a decaglycerine skeleton is particularly preferable. As the saturated linear fatty acid residue, a lauric acid residue, myristic acid residue, palmitic acid residue, stearic acid residue, behenic acid residue or the like can be suitably exemplified, and the lauric acid residue is particularly preferable.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
The invention relates to an Ag/AgBr-MBG nanoparticle for resisting bacteria and promoting wound repair of infection, and a preparation method and an application method thereof. The nanoparticle has antibacterial and wound healing effects. The composite particles of the invention have simple preparation process and no secondary products. The Ag/AgBr-MBG has the capability of absorbing and utilizing visible light (390-780 nm), can efficiently generate Reactive Oxygen Species (ROS), has low cytotoxicity and shows good biocompatibility. The Ag/AgBr-MBG nano particles have obvious inhibition effects on escherichia coli (E.coli), staphylococcus aureus (S.aureus) and methicillin-resistant staphylococcus aureus (MRSA), and the Minimum Inhibitory Concentrations (MIC) are 10 mug/mL, so that the absorption rate of bioactive glass can be obviously improved to concentrate coagulation factors, and platelets can be activated. Compared with bioactive glass, the Ag/AgBr-MBG nano particles have the fields of resisting bacteria, promoting healing of infected wounds and the like, and have great clinical application value.
Participants will attend the 5-week CONFIDENCEProgram. This program will include attending 5 group-based sessions delivered by videoconference. Each session will last approximately 1.5 hours each and will cover topics such as how to budget, accessing community resources to displace the out-of-pocket costs of caregiving, asking for help, balancing employment and caregiving, and more.
Chronic musculoskeletal pain is significantly affected by the attitudes and beliefs of healthcare professionals and affects patient management outcomes . Adopting a biopsychosocial approach rather than a solely biomedical approach is of great importance in order to comply with current pain management guidelines and reduce both pain levels and disability . Therefore, it is important to recognize healthcare professionals' knowledge, attitudes, and beliefs regarding pain . Pain science education is a powerful strategy to manage chronic musculoskeletal pain by addressing biopsychosocial factors . It improves the understanding of pain by integrating psychological and social aspects beyond anatomical factors and provides better rehabilitation outcomes. Healthcare professionals are crucial to providing effective treatment and patient pain education and require a solid understanding of pain science principles . Many validated surveys assess health care professionals' knowledge and attitudes regarding chronic pain, but they often lack elements of modern pain science and biopsychosocial treatment orientations . To address these limitations, the Knowledge and Attitudes to Pain (KNAP) questionnaire was developed to assess modern pain science and biopsychosocial attitudes toward pain. The KNAP questionnaire consists of 30 items divided into two domains. It is scored using a 6-point Likert scale and has been validated in Brazilian Portuguese, French, Spanish, and Japanese .Therefore, the aim of this study was to adapt the KNAP questionnaire for Turkish physiotherapists and to rigorously examine its psychometric properties among physiotherapy graduates and students in Turkey. The study aims to validate the questionnaire to accurately assess pain knowledge, attitudes, and beliefs by analyzing internal consistency, structural and construct validity, reliability, sensitivity, and interpretability.
Systems and methods for determining an actual fatigue time (AFT) for an activity are provided. The method comprises receiving a standard fatigue time (SFT) representing a time duration. The SFT is indicative of an onset of fatigue in individuals upon continuously performing the activity. The method further comprises receiving at least one external parameter and a fatigue index corresponding to the at least one external parameter. The at least one external parameter and the fatigue index are associated with the activity. The method further comprises determining the AFT for the activity based upon the SFT and the fatigue index.
P. acnes are skin pathogens known to cause surgical site infections despite proper preoperative surgical preparation. Lee et al. showed 70% growth rate of P. acnes despite the application of Choraprep prior to sampling. However, this study was limited as it failed to utilize a control group and only investigated one preparatory technique. Meanwhile, there remains to date no study investigating the effect of topical treatments. The purpose of this study is to investigate how specific topical treatments affect growth in the dermal layer. 12 volunteers who are normal volunteers, students, or employees of USC will each receive 4 punch biopsies from their back above the scapular spine, with each biopsy taken from a region of the skin treated with a different topical (topical clindamycin alone, topical benzoyl peroxide alone, topical clindamycin and benzoyl peroxide together, and a control). A 3df overall test of the treatment indicators will test for any differences in positivity for P Acnes among the treatments; pairwise comparisons among the treatments will adjust for multiple comparisons. A two-tailed statistical test will be performed, testing at an alpha of 0.05, and analyses will also be performed based on hemolytic subtypes.
The study aimed at assessing the effects of a periarticular pressure stimulation of the knee joint on quadriceps strength and neuromuscular activity in patients with end-stage knee osteoarthritis.

Twenty-five patients with end-stage knee osteoarthritis and and twenty-five age-matched healthy subjects will be enrolled. Participants will seat on a dynamometer chair (BAR, OTBioelettronica, Italy) with hips and knees at 90 degrees and 30 degrees of flexion, respectively. Participants will perform six maximal voluntary knee extension tasks with three different pressure stimuli in terms of intensity (0 mmHg, 60 mmHg, 120 mmHg) around the knee using a sphygmomanometer. Two maximum voluntary contractions interspaced by 3 minutes of rest will be performed for each pressure level, and the peak force (N) will be collected and normalized for the highest value during the three conditions. Moreover, root-mean-square peak (RMS-peak) of rectus femoris, vastus medialis, and vastus lateralis will be recorded using bipolar surface electromyography electrodes (FREEEMG, BTS, Italy). The RMS-peak of each muscle will be normalized for its highest value among the three conditions (nRMS-peak) and used as index of neuromuscular activity.
PCT No. PCT/SE96/01736 Sec. 371 Date Feb. 13, 1997 Sec. 102(e) Date Feb. 13, 1997 PCT Filed Dec. 20, 1996 PCT Pub. No. WO97/25065 PCT Pub. Date Jul. 17, 1997An oral pharmaceutical dosage form comprising a proton pump inhibitor and one or more prokinetic agents in a fixed formulation, wherein the proton pump inhibitor is protected by an enteric coating layer. The fixed formulation is in the form of multilayered tablets, capsules or multiple unit tableted dosage forms. The multiple unit dosage forms are most preferred. The new fixed formulation is especially useful in the treatment of disorders associated with gastro oesophageal reflux diseases.