anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
540,383. Polyvinyl resin compositions. BAKELITE, Ltd. April 12, 1940, No. 6700. Convention date, Aug. 8, 1939. [Class 2 (iii)] A moulding composition, suitable for the making of dentures, comprises a co-polymer having a molecular weight of at least 15,000 derived from a vinyl halide and a vinyl ester of a lower aliphatic acid containing not more than six carbon atoms in the molecule, and between 30 and 50 per cent. of a monomer ef an ester of acrylic acid or of a lower alkyl, alkylene, aryl or aralkyl substituted acrylic acid, the proportion of monomer being calculated on the combined weight of the polymer and monomer. The co-polymer contains between 75 and about 90 per cent. of vinyl halide, and may be derived from a mixture of 90 per cent. vinyl chloride and 10 per cent. vinyl acetate. The composition may include a stabilizer, e.g. calcium stearate, dibutyl tin oxide or hydroquinone, dyes or pigments, e.g. cadmium yellow, rhodamine, or titanium compounds, and a polymerization catalyst, e.g. benzoyl peroxide. The composition may be prepared by grinding the copolymer with pigment or dye and stabilizer and adding the liquid monomer to the mixture, e.g. by spraying ; the mixture may be allowed to stand, and the mass then pressed in a warm steel mould to form a sheet or plate ; alternatively, the co-polymer may be dissolved in monomer and the excess monomer distilled off until a viscous mass is obtained, the mass being then poured into pans and the evaporation of the monomer continued until a sheet is formed. In making dentures, the composition is packed into a plaster investment preferably heated to about 80‹C., and the flask closed ; the flask is then placed in a dental vulcanizer, e.g. for about 60 minutes, the temperature being maintained at about 100‹ to 130‹C., and the pressure ranging up to 25 lb. per square inch, during which process the monomer is polymerized. In examples, the composition comprises a copolymer of vinylchloride and vinyl acetate and monomeric ethyl methacryate, isopropyl methacrylate, or methylmethacrylate with or without allylmethacrylate, isopropyl methacrylate, ethyl methacrylate or benzyl methacrylate. Specifications 426,744 and 484,343 are referred to.
FIELD: production of cosmetics for hair care. SUBSTANCE: cosmetic composition comprises at least one special silicone-acrylate copolymer and at least one non-cellulose thickener. Silicon-acrylate copolymer is produced by providing free radical polymerization of at least one monomer with double bond a) in the presence of at least one silicone derivative; b) comprising hydroxyalkylated groups. Method for keeping and/or doing hair involves using said composition. EFFECT: increased efficiency in doing or keeping hair, provision for cosmetic properties without dusting effect. 13 cl
Organ donation after euthanasia (ODE) is a complex procedure involving the patient, the family, and the medical staff. Most organ donations occur from patients declared brain dead, and healthcare professionals rely on surrogate decisions, or the possible expression of ante-mortem will. Organ donation from deceased individuals is thus feasible under rigorous conditions, while direct donation after euthana-sia is not possible. The scientific community has not reached a shared conclusion. It is also difficult to quantify the number of patients who would be medically eligible to donate organs after euthanasia. In keep-ing with the core the principle of self-determination, any decision to undergo euthanasia (with or without organ donation) must be voluntary and not influenced by external pressures. For this reason, the physician should avoid informing the patient about the possibility of donating their organs before their request for euthanasia is evaluated. Just as noteworthy is the issue of healthcare providers' conscientious objec-tion and the receiving patient's right to know whether the transplanted organs come from a subject who underwent euthanasia. Finally, the patient who requests to end their life does so primarily because they are tormented by unbearable suffering and often expresses, as a last wish, the desire to exercise their free will regarding their own body. Organ donation after euthanasia would therefore seem to reinforce patient autonomy and self-esteem, thus giving a different meaning to their inevitable death, which is useful in saving the lives of others.
Pulmonary arterial hypertension (PAH) is characterized by persistently elevated pulmonary artery pressure and vascular resistance. Sympathetic overactivity in hypertension participates in pulmonary vascular remodeling and heart failure. The present study aims to explore the efficacy of highly selective thoracic sympathectomy (HSTS) on lowering pulmonary artery pressure, reversing pulmonary vascular remodeling, and improving right ventricular function in rats. A total of 24 Sprague-Dawley rats were randomly assigned into the control group ( n = 8) and experimental group ( n = 16). Rats in the control group were intraperitoneally injected with 0.9% normal saline, and those in the experimental group were similarly administered with received monocrotaline (MCT) injections at 60 mg/kg. Two weeks later, rats in the experimental group were further subdivided randomly into the MCT-HSTS group ( n = 8) and MCT-sham group ( n = 8), and they were surgically treated with HSTS and sham operation, respectively. Two weeks later, significantly lowered mean pulmonary artery pressure (mPAP), pulmonary artery systolic pressure (sPAP), and the ratio of sPAP to femoral artery systolic pressure (sFAP) were detected in the MCT-HSTS group than those of the MCT-sham group. In addition, rats in the MCT-HSTS group presented a significantly lower ratio of vascular wall area to the total vascular area (WT%), right ventricular hypertrophy index, and degrees of right ventricular fibrosis and lung fibrosis in comparison to those of the MCT-sham group. HSTS significantly downregulated protein levels of inflammasomes in pulmonary artery smooth muscle cells (PASMCs). Collectively, HSTS effectively reduces pulmonary artery pressure, pulmonary arteriolar media hypertrophy, and right ventricular hypertrophy in MCT-induced PAH rats. It also exerts an anti-inflammatory effect on PASMCs in PAH rats by suppressing inflammasomes and the subsequent release of inflammatory cytokines.
Participants treated with sitagliptin 100 mg, once daily, for 24 weeks. All participants will be under treatment with a stable dose of insulin with or without metformin for ≥10 weeks before and throughout the study. All participants will receive placebo during the Placebo Run-in period.
OBJECTIVE: Multiple myeloma cells resist standard therapies due to overexpression of the transport protein, exportin 1. Selinexor is a novel drug that targets the Exportin 1 protein in these cells.
DATA SOURCE: A comprehensive search was done, and data showing the efficacy and safety of selinexor in relapsed/refractory multiple myeloma was collected using PubMed, Google Scholar, and clincialtrials.gov.
DATA SUMMARY: Results from the clinical trials STORM, BOSTON, and STOMP were included. Parts I and II of the STORM trial revealed a progression-free survival (PFS) of 4.7 and 3.7 months, a median duration of response of 6.2 and 4.4 months, and an overall survival of 7.3 and 8.4 months, respectively. BOSTON trial's SVd arm (selinexor, bortezomib, and dexamethasone) had a median follow-up period of 13.2 months and an mPFS of 13.93 months. The Vd arm (bortezomib and dexamethasone) had a median follow-up duration of 16.5 months and an mPFS of 9.46 months. The STOMP trial is still active and has limited data available. The SKd arm (selinexor, carfilzomib, and dexamethasone) reported an overall response rate of 66.7% in patients with triple refractory multiple myeloma, and 82% in patients with high-risk cytogenetics. The SPd arm (selinexor, pomalidomide, and dexamethasone) shows an overall response rate of 54.30% in pomalidomide naïve-nonrefractory, 35.70% in pomalidomide refractory and 60% in those dosed at RP2D. SRd arm (selinexor, lenalidomide, and dexamethasone) shows an overall response rate of 91.7% in lenalidomide naïve and 12.5% in lenalidomide refractory patients. SVd (selinexor, bortezomib, and dexamethasone) arm reported an overall response rate of 63% in all patients while the SDd arm (selinexor, daratumumab, and dexamethasone) showed an overall response rate of 73%.
CONCLUSION: To improve the outcome of patients with relapsed/refractory multiple myeloma, it is critical to develop new therapies, assess potential therapeutic synergies, and overcome drug resistance by determining the efficacy of multiple myeloma therapies across multiple disease subgroups.
The binding of ciprofloxacin to serum proteins is 20 to 40% which is not likely to be high enough to cause significant protein binding interactions with other drugs.  
  
After oral administration, ciprofloxacin is widely distributed throughout the body. Tissue concentrations often exceed serum concentrations in both men and women, particularly in genital tissue including the prostate. Ciprofloxacin is present in active form in the saliva, nasal and bronchial secretions, mucosa of the sinuses, sputum, skin blister fluid, lymph, peritoneal fluid, bile, and prostatic secretions. Ciprofloxacin has also been detected in lung, skin, fat, muscle, cartilage, and bone. The drug diffuses into the cerebrospinal fluid (CSF); however, CSF concentrations are generally less than 10% of peak serum concentrations. Low levels of the drug have been detected in the aqueous and vitreous humors of the eye.
<P>PROBLEM TO BE SOLVED: To solve problems in conventional products massively manufactured by big companies requiring such as a plurality of processes and mechanical appliances, wide ranges in the amount of smoking by persons with various nicotine dependence liabilities and forcing woes by a definite strength of percutaneous absorption seal.  <P>SOLUTION: A required amount of tobacco 3 for a user oneself is attached on an adhesive surface of seal 1a, covered the whole tobacco 3 with a thin cloth 2 and glued on the adhesive surface of seal 1a leaving a sufficient adhesive surface to adhere on the body. A few drops of a liquid is dropped on the thin cloth 2 and gently pressed to fully adapt the liquid to show the surface of thin cloth 2 faint brown and applicable. The outside of adhesive seal 1b shall be water proof. The process for nonsmoking may take the quitting therapy fit to the smoker such as decrease of 1 cm for every 3 days and 5 mm for every other week, and the success rate will increases.  <P>COPYRIGHT: (C)2010,JPO&INPIT
Participants assigned to lebrikizumab Q2W arm will receive investigational product Q2W by SC injection. Some participants will receive loading doses.
Gabapentin enacarbil was administered orally once daily after the evening meal. Participants with an estimated creatinine clearance of ≥ 60 mL/min to \< 90 mL/min at the start of the run-in period were administrated gabapentin enacarbil 300 mg for 1 week followed by gabapentin enacarbil 600 mg for 11 weeks.
Intracerebral hemorrhage (ICH) is a common and devastating type of stroke, marked by significant morbidity and a grim prognosis. The inflammation cascade triggered by astrocytes plays a critical role in secondary brain injury (SBI) following ICH, leading to detrimental effects such as cell death. However, effective intervention strategies are currently lacking. This study aims to investigate the role of the astrocyte cascade reaction following ICH and identify potential intervention targets. Utilizing the GSE216607 and GSE206971 databases for analysis, we established a mouse autologous blood model. Firstly, our research revealed a significant activation of the autophagy pathway following intracerebral hemorrhage (ICH), with a notable upregulation of Lamp2a, a key factor in chaperone-mediated autophagy (CMA), primarily localized in astrocytes. Additionally, the downregulation of Lamp2a resulted in a significant augmentation of A1 reactive astrocytes, concomitant with a reduction in myelin coverage area, heightened neuronal injury, exacerbated motor and sensory deficits, and diminished neurological scores after ICH in mice. Conversely, CA77.1, an activator of CMA, could reverse ICH-induced augmentation of A1 reactive astrocytes, myelin damage, neuronal death, and neurobehavioral disorders. In conclusion, the activation of astrocyte CMA following ICH can exert neuroprotective effects. Lamp2a represents a promising therapeutic target for post-ICH treatment.
AIM: Malignant vasovagal syncope in children seriously affects their physical and mental health. Our study aimed to explore the efficacy of catheter ablation in ganglionated plexus with malignant vasovagal syncope children.
CONCLUSION: Catheter ablation of ganglionated plexus was safe and effective in children with malignant vasovagal syncope and can be used as a treatment option for these children.
METHODS: A total of 20 children diagnosed with malignant vasovagal syncope were enrolled in Beijing Children's Hospital, affiliated with Capital Medical University. All underwent catheter ablation treatment of ganglionated plexus. Ganglionated plexuses of the left atrium were identified by high-frequency stimulation and/or anatomic landmarks being targeted by radiofrequency catheter ablation. The efficacy of the treatment was evaluated by comparing the remission rate of post-operative syncopal symptoms and the rate of negative head-up tilt results. Safety and adverse events were evaluated.
RESULTS: After follow-up for 2.5 (0.6-5) years, the syncope symptom scores were decreased significantly compared with before treatment [3 (2-4) versus 5 (3-8) scores, P < 0.01]. Eighty-five per cent (17/20) children no longer experienced syncope, whilst 80% (16/20) children showed negative head-up tilt test after treatment. No adverse effects such as cardiac arrhythmia occurred in the children.
The study group does reformer pilates for 45 minutes 3 days a week. The intensity of the workouts was gradually increased. Warm-up (10 minutes), main Pilates training activity (25 minutes), and cool-down (10 minutes) were the three parts of each session (10 minutes). In addition to pilates, the women in the SG followed a personalized weight loss diet. In accordance with Turkey Dietary Guidelines, these diet plans were designed to provide 45-60% of energy from carbohydrates, 10-20% from protein, and 20-35 percent from fat.
1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age. All clinical samples have been collected and tested uniformly. Correlation analysis between KLK8 and age will be performed by using Statistical Package for the Social Sciences (SPSS) 22.0 software, and P\<0.05 indicates a statistically significant difference. The obtained clinical data should be recorded on survey forms, and researchers should verify patient information by recording basic information such as age and gender.
2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation. All clinical samples have been collected and tested uniformly. Correlation analysis between endothelial/epithelial damage index, age and duration of mechanical ventilation will be performed by using SPSS 22.0 software, and P\<0.05 indicates a statistically significant difference. The obtained clinical data should be recorded on survey forms, and researchers should verify patient information by recording basic information such as age and gender.
Regarding neurophysiological and developmental findings, anxiety and depression are usual comorbidities of gastritis patients. However, research related to anxiety and depression among chronic gastritis patients was conducted on the disease level while ignoring symptoms. Hence, we rendered the network approach to reveal the symptoms of anxiety and depression among chronic gastritis patients. Three hundred and sixty-nine chronic gastritis patients (female = 139, Mage = 55.87 years) were asked to complete the Self-Rating Anxiety Scale and Self-Rating Depression Scale. Three symptom networks and one directed acyclic graph (DAG) network were formed. First, in the anxiety network of chronic gastritis patients, dizziness was the most influential symptom. In the depression network of chronic gastritis patients, depressed affect and psychomotor retardation were the influential symptoms. Second, panic, easy fatiguability, weakness, palpitation, depressed affect, tachycardia, fatigue, and psychomotor agitation bridged the anxiety-depression network of chronic gastritis patients. Third, DAG networks showed that anxiousness and hopelessness could trigger other symptoms in the anxiety-depression networks of chronic gastritis patients. The current study provided insightful information on patients with chronic gastritis by examining the structures of symptoms.
Minimum of 1x10\~7 cells to maximum of 2x10\~6 cells/kg. Single infusion.
Participants were enrolled into the study on their stable twice-daily (bid) dose of tacrolimus on Day 1 and continued to receive a stable bid dose of tacrolimus through Day 7. Participants then converted to Tacrolimus Modified Release (MR), administered once daily at an equivalent dose to the patient's previous stable total daily dose of tacrolimus. Participants who completed the 4-week pharmacokinetic treatment period with tacrolimus MR could continue receiving tacrolimus MR as part of the extended treatment period of the study. Dose adjustments were allowed in order to maintain tacrolimus trough concentrations within the target range of 5 to 15 ng/mL and for clinical reasons.
Participants will receive a single dose of rosuvastatin in the morning of Day 1 in Treatment Period 1. Following a washout period of 5 days, participants will receive ALXN2040 three times daily on Days 1 through 7 in treatment period 2.
Incident cases of IBD in the Songpa-Kangdong district, a well-defined administrative area in Seoul, the capital of Korea, beginning in 1986, when the first patient with IBD was diagnosed, until 2017. For the prevalent cases, the inhabitants with IBD at Dec 31, 2007 in the Songpa-Kangdong district are included.
FIELD: pharmaceutical industry, pharmacy. SUBSTANCE: vaseline and lanolin as components of the ointment base are melted and mixed with a medicinal agent. After melting components of ointment base are dehydrated and sterilized. Used vaseline has no reducing agents and used lanolin shows peroxide number 15, not above. Mixing with medicinal agent is carried out at 38- 42 C when medicinal agent is glycifon and at 28-32 C when tetracycline is used. Mixture is thermostatically controlled, homogenized, cooled and packaged. All operations are carried out in sealed equipment. Invention ensures to obtain compositions stable in storage. EFFECT: improved method of production. 2 tbl, 2 ex
The invention relates to reflexology and is intended for monitoring and correcting the functional state of the human body on the basis of thermal pain threshold measurements taken at acupuncture points at the inlet/outlet of the primary channels. The device comprises a diagnosis and treatment module (1), a control and communication unit (2) and a server (3), which are linked by bidirectional communication channels (12, 13). The module (1) is in the form of a pen (32) with an independent power supply (10) and a receiving and transmitting unit (11). The module (1) is provided with an element for exercising a thermal effect on the acupuncture points, which is in the form of an infrared light-emitting diode (4) connected to a controlled current generator (6), a radiation indicator (5), a start/stop switch (7), an input/output unit (8) and a microcontroller (9). The control and communication unit (2) takes the form of a patient's mobile telephone or computer, which is assigned the functions of data receipt and transmission, data display and module (1) control by the loading of a resident program thereon. The pen (32) serves as a peripheral state sensor and a treatment device that is inexpensive for the patient, and all processing of individual patient data is carried out on the server (3). The technical result is an increase in the efficiency with which computing resources are used, a reduction in the cost of the patient apparatus and an increase in the functional capabilities of the device.
Cohort 1: 50 ug/m2 given Intravenous. Cohort 2: 150 ug/m2 given Intravenous. Cohort 3: 250 ug/m2 given Intravenous. Cohort 4: 0 ug/m2 and vehicle (normal saline) given Intra-tumoral. Cohort 5: 50 ug/m2 given Intra-tumoral. Cohort 6: 150 ug/m2 given Intra-tumoral. Cohort 7: 250 ug/m2 given Intra-tumoral.
Inspiratory muscle training will be done with a resistive exercise device at 80% of MIP max and for 30 breaths. Foam roller application will not be done.
Street foods are often of poor nutritional quality with high sugar content, in which the overconsumption of sugar is associated with obesity. However, sugar content information on local street foods is scarce. Thus, the individual and total sugar contents of 94 types of street foods in Malaysia were analysed. Compared to snacks and main meals, desserts contained the highest amounts of sugar, sucrose, fructose, glucose, and maltose. Sucrose was predominant in 90% desserts, 79.3% snacks, and 68.6% main meals. Most desserts (93.3%) contained medium to high sugar content (≥5 g to >15 g/100 g), while 82.9% main meals and 65.5% snacks had low sugar content. When comparing the sugar contents of 39 foods with other local databases, 58.3% main meals, 55.6% desserts, and 33.3% snacks contained either significantly (p < 0.05) higher or lower sugar contents. Consumers can identify low and high-sugar foods, and policymakers can review health priorities to combat obesity.
Patients assigned to routine thermal management will not be pre-warmed and ambient intraoperative temperature will be maintained near 20°C per routine. Only transfused blood will be warmed. An upper- or lower-body forced-air cover will be positioned over an appropriate non-operative site but will not initially be activated. Should core temperature decrease to 35.5°C, the warmer will be activated as necessary to prevent core temperature from decreasing further. The target nasopharyngeal temperature is 35.5°C.
PROBLEM TO BE SOLVED: To obtain an antitumor agent by separating a glucomannan having a mannose chain of β-1, 2 bonds as its primary chain from an Agaricus blazei mushroom culture. SOLUTION: A mecelia is grown by inoculating an Agaricus blazei mushroom spawn to a liquid culture medium for basidiomycetes and shake-culturing it in an aerobic condition at 30 deg.C for 14 days. The mecelia is obtained by centrifugalizing the culture system. A extractive liquid is obtained by adding water 10 times as much to the mecelia and carrying out a hot water extraction under boiling for 2 hr. After the extractive liquid is vacuum-concentrated to 1/10, a supernatant liquid is obtained by centrifugation. The equal amount of 99% ethylalcohol is added to the supernatant liquid to precipitate polysaccharides. The precipitate is obtained by centrifugation and freeze-dried.  The freeze-dried material is subjected to further treatments such as salt-out, separation, elution and the like to give a glucomannan having a mannose chain of β-1, 2 bonds as its primary chain of the formula (wherein Glc is a glucose residual group; and Man is a mannose residual group). This glucomannan exhibits a strong antitumor action.