anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Polycystic ovary syndrome (PCOS) is a common endocrine disorder that affects approximately 8% to 13% of women of reproductive age worldwide. It is characterized by a range of symptoms, including hirsutism, acne, and menstrual irregularities, and poses a significant psychological burden, including anxiety and depression. The evolving definition of PCOS, from the 1990 NIH conference to the 2003 Rotterdam conference, highlights its multifaceted nature, encompassing metabolic, reproductive, and psychological aspects. This overview aims to elucidate the complex interplay between PCOS's physiological and psychological dimensions. It focuses on understanding the heightened risk of psychiatric disorders, including depression and anxiety, among women with PCOS and explores the contributing factors, such as obesity, body image issues, and stress. The etiology of PCOS involves a complex mixture of genetic, hormonal, and lifestyle factors that contribute to its pathophysiology and the associated mental health challenges. Stress, in various forms, including metabolic, inflammatory, oxidative, and emotional, is identified as a significant contributor to the pathogenesis of PCOS. Management strategies highlighted include lifestyle modifications, dietary and exercise interventions, and psychological therapies, underscoring the need for comprehensive and integrated care approaches that address the broad spectrum of PCOS effects. A multifaceted treatment approach that goes beyond just the physical symptoms of PCOS to also include its significant psychological effects is emphasized, reinforcing the necessity for a comprehensive, integrated care strategy to manage this complex condition effectively.
The invention discloses a pancreatitis-type DHAV-1 (duck hepatitis A virus type 1) attenuated vaccine strain A75. The attenuated vaccine strain is reserved at China General Microbiological Culture Collection Center under the number of CGMCC NO. 10492. According to the attenuated vaccine strain, no pathogenicity is produced on ducklings, the immunogenicity is good, mass cell proliferation can be achieved, and excellent immunization and preventive effect can be achieved when prepared attenuated live vaccines are used on the ducklings. The preparation method of the attenuated live vaccines is low in cost which is 1/8 of that of existing DHAV-1 live vaccines, and applicable to large-scale cell cultivation. Not only can diseases caused by pancreatitis-type DHAV-1 be prevented effectively, but also cross contamination between viruses carried in duck blastochyle can be avoided. The immunogenicity of the prepared vaccine is good, the immune protection rate of the vaccine is higher than 96.7%, and thus, wide application prospect can be achieved.
Patients enrolled in this trial will receive study drug (RRx-001) on Day 1 as a single agent. Nivolumab (3 mg/kg) will be administered on Day 2 or Day 3 as a single agent.
The invention provides a pure plant coloring agent, which comprises an agent A and an agent B, wherein the agent A is plant active coloring freeze-dried powder, and the agent B is a traditional Chinese medicine extracting solution. The preparation A comprises lyophilized powder of Juglandis pericarpium Citri Reticulatae viride, lyophilized powder of Mori fructus, and lyophilized powder of rhizoma Zingiberis recens. The preparation B comprises various traditional Chinese medicines and the balance of deionized water according to different effects on hair. Mixing the agent A and the agent B, uniformly coating the mixture on clean hair, and keeping the temperature for half an hour. The hair dye adopts natural plants as main components of the hair dye, and does not contain any harmful components. In addition, the freeze drying technology is adopted to keep the activity of the effective dyeing components of the natural plants. Meanwhile, the nutrient components are added to promote the hair to absorb the nutrition, so that the hair is more smooth.
AIM: We investigated survival rates after scoliosis correction in individuals with Duchenne muscular dystrophy (DMD) and evaluated factors that can affect them.
METHOD: This was a retrospective cohort study from 2000 to 2022 with a minimum 2-year postoperative follow-up. We reviewed the hospital records/spinal radiographs and analysed data with XLSTAT. Kaplan-Meier and multivariate Cox regression survival analysis was performed.
RESULTS: Forty-three patients had a mean age at surgery of 14 years 5 months. Mean postoperative follow-up was 10 years 10 months. There was no operative or 30-day postoperative mortality in this group. Twenty-four patients died because of cardiorespiratory failure. Median survivorship was 14 years 2 months, with the longest observed survival being 22 years 6 months given the limitation of the length of postoperative follow-up. The degree of preoperative coronal imbalance and pelvic obliquity, as well as intraoperative blood loss, were factors that significantly affected survival. The impact of preoperative sagittal imbalance and extension of the fusion to the sacrum/pelvis trended towards significance. In contrast, age at surgery, preoperative/postoperative scoliosis, thoracic kyphosis, lumbar lordosis, scoliosis and pelvic obliquity flexibility or correction indices, postoperative coronal/sagittal balance, need of preoperative non-invasive ventilation, preoperative feeding disorders, development of surgical complications, and length of hospital and intensive care unit stay were exposure variables that did not affect postsurgical survival in patients with DMD.
INTERPRETATION: Survival of up to two decades or more was possible among young patients with DMD after scoliosis correction. This was affected by factors that related to disease and deformity severity, as well as surgical morbidity.
WHAT THIS PAPER ADDS: There was no operative or 30-day postoperative mortality in this group of patients with Duchenne muscular dystrophy (DMD) undergoing scoliosis correction. Survival probabilities at 5-year, 10-year, 15-year, and 20-year intervals post-surgery were 92%, 80%, 33%, and 12% respectively. Scoliosis surgery achieved good deformity correction and a balanced spine that was maintained at follow-up. Respiratory failure, severe pneumonia, and left ventricular failure were the leading causes of death in the study participants. Preoperative global coronal imbalance, pelvic obliquity, and intraoperative blood loss significantly predicted survival. Factors that affected survival after scoliosis surgery were associated with perioperative morbidity and disease or deformity severity in the DMD group.
After successful piloting of the mentoring program "Peer2Me", the mentoring program developed by us is now to be implemented and evaluated in a large-scale study in a second step, in order to be able to derive clinically relevant results.

A total of 180 acutely ill adolescent and young cancer patients (AYA) between the ages of 18 and 39 will be included in the study (intervention and control group). Again, young former cancer patients who have completed treatment will act as mentors and accompany acutely ill AYAs in the period after diagnosis for a period of three months. Prior to their assignment, the mentors take part in a training course, which includes the teaching of suitable conversation techniques, core topics in dealing with the cancer and advice on further care structures. Patients in the control group receive 30 minutes of standardized counseling regarding psychosocial care needs, including appropriate informational materials, during AYA consultation hours at both clinic sites. The study includes three measurement time points: t1: before the intervention; t2: after the end of the intervention; t3: 3 months after the end of the intervention. At all time points, participants will be surveyed using standardized questionnaires. With the help of these data and a comprehensive statistical analysis, the investigators want to make valid statements regarding the effects of peer mentoring on changes in psychological well-being as well as on social support and coping with illness.
Contrast-enhanced spectral mammography (CESM) is an FDA approved tool for breast cancer detection. However, adoption into clinical practice has been slow. In this study, we will explore patient issues related to the use of CESM for breast cancer screening. For this study, 210 women with heterogeneous or dense breast tissue reported on a previous mammogram, will be recruited to undergo a screening Contrast-enhanced Spectral Mammography (CESM). The CESM will serve as the subject's annual screening breast exam for clinical care. A survey will be administered before and after the examination that evaluates the patient experience. Women will not be at high risk for breast cancer (\<20% lifetime risk). All abnormal findings will be acted upon independently. Results of the general screening population survey will be compared with those of women who choose to undergo the CESM examination in order to evaluate the influence of age, education, and lifetime risk on decision making about advanced screening.
FIELD: chemical-pharmaceutical industry and technology. SUBSTANCE: ondansetron hydrochloride dihydrate is prepared by mixing 3-[(dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carb- azole-4-one and 2-methylimidazole in medium of 55-65% aqueous dioxane in the presence of triethylamine at 33-42 C followed by mixture cooling and water addition. Obtained precipitate is filtered off, washed with water and suspended in 70-80% aqueous acetone followed by addition of hydrochloric acid and settling the reaction mixture for 0.5-1.5 h. Then acetone is added, precipitate is separated and dried at the room temperature. Obtained substance has crystals (size is less 90 mcm) being 95% of crystals have the size less 60 mcm. EFFECT: stable and pure product making. 8 cl, 2 tbl
A method and apparatus for joining a new web of material to a moving web in a packing machine is disclosed. The beginning end of the new web is secured in a joining unit which is positioned over the moving web. The joining unit has a pivotably mounted cutting device which is actuated by a piston to cut the moving web. The operation of the joining unit is synchronized with that of the packing machine by a stationary cam over which a follower attached to the cutting device is displaced. When the moving web is about to run out, the joining unit is activated so that the moving web is cut off while the new web is automatically attached to the remaining running length by means of adhesive tape. The automatic joining unit eliminates the need to shut down operation of the packing machine when the web of material runs out.
The intervention group is a group of asthmatic children aged 6-11 years, determined by randomization. Yoga asana includes pranayama and concentration. It will be held 3 days a week for 12 weeks.
The utility model provides a first beautiful machine finger protecting film. The utility model discloses a nail art machine, which comprises a printing film module, wherein the printing film module comprises at least one printing film execution module, the printing film execution module comprises a printing film, and the printing film execution module can receive, release, wind and move the printing film; comprises an engraving module which can engrave patterns on a printing film; the printing film module can press the printing film with the carved pattern on the finger; comprises a spray painting module which can spray and/or paint the pigment/nail polish on the pattern of the printing film so as to print the pattern on the nail. The finger protection film can be cut from the printed film. The lower surface of the finger protective film is provided with adhesive which can be adhered to the skin around the fingernail. The shape of the inner ring outline of the protective film is a two-dimensional topological graph of a three-dimensional outline of a nail. At least one slit can be arranged on the protective film. The protective film can comprise 2/a plurality of sub-films, and when in use, the sub-films are respectively pasted on corresponding positions around the fingernails to form the complete protective film. The finger protective film can prevent the pigment from dirtying the skin around the nail.
BACKGROUND: While intermittent fasting leads to weight loss and improved glucose metabolism, food insecurity, the insufficient access to food for a healthy life, is associated with obesity and adverse cardiometabolic health, especially in women. We aimed to characterize the effects of intermittently restricted feeding on energy balance and glucose tolerance in female mice.
METHODS: Female C57BL/6J mice were fed a high-fat, high-sucrose diet and intermittently food restricted to 60% of control littermates' ad libitum intake, starting at weaning and until week 19. Restricted mice were subsequently allowed ad libitum access to the same diet. Body composition and energy balance were measured at weeks 18.5, 19, 30, and 40. At week 42, mice underwent an intraperitoneal glucose tolerance test and plasma appetitive hormones measurements after nutrient gavage.
RESULTS: During the food restriction phase, restricted mice accrued lower weight and fat mass than controls despite periodic ad libitum food access. Reintroduction of continuous ad libitum food caused increased food intake during the light phase and increased body mass in restricted mice. Minor differences in body composition-adjusted energy expenditure between groups were observed at week 40. At week 42, glucose tolerance was impaired in restricted mice compared to controls, and trends toward lower levels of postprandial anorexigenic hormones glucagon-like peptide-1 and pancreatic polypeptide were observed.
CONCLUSION: Our findings suggest that repeated intermittent food restriction leads to changes in eating behavior that predispose to glucose intolerance when food is freely available. Future studies are needed to elucidate the specific mechanisms underlying these changes.
INTRODUCTION: The safety and efficacy of CRS + HIPEC combined with urinary tract resection and reconstruction are controversial. This study aims to summarize the clinicopathological features and to evaluate the safety and survival prognosis of CRS + HIPEC combined with urinary tract resection and reconstruction.
METHODS: The patients who underwent urinary tract resection and reconstruction as part of CRS surgery were retrospectively selected from our disease-specific database for analysis. The clinicopathological characteristics, treatment-related variables, perioperative adverse events (AEs), and survival outcomes were studied using a descriptive approach and the K-M analysis with log-rank comparison.
RESULTS: Forty-nine patients were enrolled. Perioperative serious AEs (SAEs) were observed in 11 patients (22.4%), with urinary SAEs occurring in 3 patients (6.1%). Additionally, there were 23 cases (46.8%) involving urinary adverse events (UAEs). The median overall survival (OS) in the entire cohort was 59.2 (95%CI: 42.1-76.4) months. The median OS of the UAE group and No-UAE group were 59.2 months (95%CI not reached), and 50.5 (95%CI: 11.5 to 89.6) months, respectively, with no significant difference (P = 0.475). Furthermore, there were no significant differences in OS based on the grade of UAEs or the number of UAEs (P = 0.562 and P = 0.622, respectively).
CONCLUSION: The combination of CRS + HIPEC with urinary tract resection and reconstruction is associated with a high incidence of Grade I-II UAEs, which do not have an impact on OS. The safety profile of this combined technique is acceptable. However, this is a retrospective single-center single-arm analysis, with limitations of generalizability and potential selection bias. The findings need high-level validation.
A suspension of micro-organisms is treated to inactivate the organisms without impairing the antigenic properties of the suspension by exposure to ultraviolet light for a period of time sufficient to inactivate the organisms and either for not more than 10 seconds in a flowing film not over 1 mm. in thickness, in which the irradiated energy under 2600  is not less than 10 milliwatts per sq. cm., or for not more than three seconds in a film not over 3 mm. thickness, in which the irradiated energy between 2000   and 2600 is not less than 1.0 milliwatt per sq. cm.  Preferably not less than 0.1 milliwatt per sq. cm. of irradiated energy of below 2000   is also provided, and 10 per cent of the energy irradiated may be above 2600  .  In operation, the vaccine is caused to flow at a controlled rate through a flattend cell made of high-grade optical quartz, the cell being exposed to the ultra-violet radiation of a mercury vapour lamp, the radiating surface of which is also made of high-grade optical quartz (see Group XL (a)).  If the bacteria concerned produce toxins, the treatment should also be sufficient to detoxify the preparation.  The products may be used as vaccines or an antigens in complement-fixation tests for diagnosis.ALSO:A suspension of micro-organisms is treated to inactivate the organisms without impairing the antigenic properties of the suspension by exposure to ultra-violet light for a period of time sufficient to inactivate the organisms and either for not more than 10 seconds in a flowing film not over 1 mm. in thickness, in which the irradiated energy under 2600A is not less than 10 milliwatts per sq. cm., or for not more than three seconds in a film not over 3 mm. thickness in which the irradiated energy between 2000A and 2600A is not less than 1.0 milliwatt per sq. cm.  Preferably not less than 0.1 milliwatt per sq. cm. of irradiated energy of below 2000A is also provided, and 10 per cent of the energy irradiated may be above 2600A.  In operation, the vaccine is caused to flow at a controlled rate through a flattened cell made of high-grade optical quartz, the cell being exposed to the ultra-violet radiation of a mercury vapour lamp, the radiating surface of which is also made of high-grade optical quartz (see Group XL(a).  If the bacteria concerned produce toxins, the treatment should also be sufficient to de-toxify the preparation.  The products may be used as vaccines or as antigens in complement-fixation tests for diagnosis.  Specified microorganisms treated are B.Coli, equine encephalomyelitis, rabies (suspension of infected brain), Eberthella typhi (strain 58), Salmonella enteritidis, staphylococcus aureus, pneumococcus, lymphocytic choriomeningitis viruses, and Shiga dysentery organisms.
Chilblain is a lesion of localized extravasated skin inflammation caused by cold. Can cause itching, erythema, swelling and blister of hands and feet, and can also cause local skin ulceration, suppuration and the like in serious cases. The chilblain is warm and itchy, and pain is hard to endure when it is cold, and it is better at the peripheral or exposed parts of the limbs, such as hands, auricles, and nose tip. The rhagades are a disease belonging to dry and cracked skin, and are usually seen in cold and dry winter, the rhagades are shallower in mild cases, and reach the dermis layer of the skin in severe cases, and redness and bleeding are generated in the rhagades, and pain is caused. The chilblain and the frost cracking caused by the cracks are not easy to be cured. The invention relates to a medicinal oil for treating frost crack, which is prepared by soaking 50 g of angelica, 60 g of lithospermum, 10 g of honeysuckle stem and 20 g of raw sanguisorba in 500 ml of sesame oil for 24 hours, heating in an iron pan, cooling and filtering dregs.
The diffusion of oxygen through capillary to surrounding tissues through multiple points along the length has been addressed in many clinical studies, largely motivated by disorders including hypoxia. However relatively few analytical or numerical studies have been communicated. In this paper, as a compliment to physiological investigations, a novel mathematical model is developed which incorporates the multiple point diffusion of oxygen from different locations in the capillary to tissues, in the form of a fractional dynamical system of equations using the concept of system of balance equations with memory. Stability analysis of the model has been conducted using the well known Routh-Hurwitz stability criterion. Comprehensive analytical solutions for the differntial equation problem in the new proposed model are obtained using Henkel transformations. Both spatial and temporal variation of concentration of oxygen is visualized graphically for different control parameters. Close correlation with simpler models is achieved. Diffusion is shown to arise from different points of the capillary in decreasing order along the length of the capillary i.e. for the different values of z. The concentration magnitudes at low capillary length far exceed those further along the capillary. Furthermore with progrssive distance along the capillary, the radial distance of diffusion decreases, such that oxygen diffuses only effectively in very close proximity to tissues. The simulations provide a useful benchmark for more generalized mass diffusion computations with commercial finite element and finite volume software including ANSYS FLUENT.
The present invention describes methods and compositions for the treatment of neurodegenerative conditions including Alzheimer's disease (AD) and aging. The present invention discloses an anaplerotic diet therapy for the treatment of AD. The high fat, low carbohydrate diet described in the various embodiments of the present invention increasing circulating ketone bodies, reduces amyloid-Î² (AÎ²) deposition in AD patients, thereby improving cognition and locomotive skills. The present invention describes methods and compositions for the treatment of neurodegenerative conditions including Alzheimer's disease (AD) and aging. The present invention discloses an anaplerotic diet therapy for the treatment of AD. The high fat, low carbohydrate diet described in the various embodiments of the present invention increasing circulating ketone bodies, reduces amyloid-Î² (AÎ²) deposition in AD patients, thereby improving cognition and locomotive skills. Methods and apparatus in a wireless communication system are described for receiving and processing transmit power control commands, where, for example, the response to the transmit power control commands is conditionally decoupled from at least one of a transmit bandwidth parameter, a transport format parameter and a power stepsize limit. This Abstract is provided for the sole purpose of complying with the Abstract requirement rules that allow a reader to quickly ascertain the disclosed subject matter. Therefore, it is to be understood that it should not be used to interpret or limit the scope or the meaning of the claims.
1515963 Cross-linked polymer of collagen and a mucopolysaccharide MASSACHUSETTS INSTITUTE OF TECHNOLOGY 8 July 1976 [15 July 1975] 28359/76 Heading C3H A cross-linked polymer of collagen and a mucopolysaccharide obtained by reacting collagen with the mucopolysaccharide and cross-linking the product is characterized in that the polymer is cross-linked to an Mc value of 800-60,000 and contains at least 0À5% by weight of said mucopolysaccharide irreversibly bound to said collagen. The polymer may be produced by dipping fibres, sheets, films and tubes made of collagen into a solution of mucopolysaccharide. The cross-linking may be achieved with a chemical cross-linking agent, e.g. glutaraldehyde, dehydrothermal crosslinking, or by radiation. The mucopolysaccharide is preferably chondroilin 6-sulphate, chondroitin 4-sulphate, heparin, keratan sulphate, heparan sulphate, dermatan sulphate or hyduronic acid. The cross-linked polymer may be formed into a suture or prosthesis.
In MRD- deferred adjuvant therapy group, patients won't get the standard CAPEOX adjuvant therapy at first. When MRD negative status turns to positive status, the 3-month CAPEOX therapy will be arranged.