anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Prepn. of 1,5-benzothiazepines of formula (I) (Ar is phenyl substd. with 1-4C alkoxy; Y is 1-4C alkylene; and R, R1 and R2 are 1-4C alkyl) comprises (i) reacting a 2-hydroxy-3-(2' aminophenylthio)-3-phenylpro pionic acid of formula (IV), in the form of a salt with a base, with an acylating agent and (ii) reacting the resulting 1,5-benzothiazepine of formula (II) or its alkali metal salt with an aminoalkyl halide of formula  Z-Y-NR1R2 (where Z is halogen). - (I) have excellent coronary vasodilating and psychoneurotic activities. They are useful particularly as Ca(2+) antagonistic coronary vasodilators.  (0/0) EPAB- EP--98892 B A process for prepg. a 1,5-benzothiazepine deriv. of the formula (I) wherein Ar is a phenyl substitd. with a lower alkoxy, R is a lower alkyl, R1 and R2 are each a lower alkyl having a 1 to 4 carbon atoms and Y is a lower alkylene having 1 to 4 carbon atoms, characterised by the steps of:  (A)-(i) reacting a 2-hydroxy-3-(2'-aminophenyl thiol)-3-phenylpropionic acid of the formula (IV) wherein Ar is as defined above which is in the form of a salt with a base, with two or more equivs. of a lower aliphatic acid anhydride, or -(ii) reacting said cpd. (IV) with less than two equivs. of a lower alkanoic acid anhydride or with one or more equivs. of a lower alkanoic acid halide, followed by reacting the resulting intermediate cpd. of the formula (V) wherein Ar andR are as defined herein, with one or more equivs. of a lower alkanoic acid anhydride, or -(iii) reacting the cpd. (IV) (in the form of free acid) with three or more equivs. of a lower alkanoic acid anhydride, followed by treating the resulting cpd. of the formula (VII) wherein Ar and R are as defined herein, with an amine, and (B) then reacting the resulting 1,5-benzothiazepine deriv. of the formula (II) wherein Ar and R are as defined herein, or an alkali metal salt thereof with one to 3 moles (per mole of the cpd. (II)) of a cpd. of the formula (III) wherein R1, R2 and Y are as defined above and Z is a halogen atom in the presence of silica gel and/or alumina in an aprotic solvent. (14pp)
Patients in this group will received facial massage, facial expression exercises and laser at predetermined eight points on the affected side of the facial muscles. the hand piece is positioned perpendicular to 8 points which is located on the superficial roots of the facial nerve of the affected side. Each point will receive an energy density of 10 J/point with total energy delivered to the patient during one session of 80 joules. The time of application 90 sec/point. laser is calibrated by the manufacture company before the starting the experiment and periodically during the sessions. The laser probe will be away from the eye region. Both patients and therapist wear a laser googles.
Arm 3 participants will receive high dose oral RIF (35mg/kg/day) for the first 4 weeks of therapy, along with standard doses of INH, PZA, and EMB. After 4 weeks, high dose RIF will return to standard dose for the remainder of treatment.
BACKGROUND: Several potential causes can impair balance in older people. The neck torsion maneuver may be useful in demonstrating impaired balance caused by the stimulation of cervical proprioceptive input. Whereas evidence suggests impaired standing balance in older people with chronic neck pain, balance impairment during the neck torsion position and its relationship with clinical characteristics have not yet been investigated in this population. The aims of this study were to investigate whether the neck torsion position could significantly influence balance responses in older people with chronic non-specific neck pain and to determine the relationships between the balance responses and characteristics of neck pain.
METHODS: Sixty-eight older people (34 with chronic non-specific neck pain and 34 controls) participated in the study. Balance was tested using a force plate during comfortable stance with eyes open under four conditions: neutral head on a firm surface, neutral head on a soft surface, neck torsion to left and right on a firm surface and neck torsion to left and right on a soft surface. Balance outcomes were anterior-posterior (AP) and medial-lateral (ML) displacements, sway area and velocity. Characteristics of neck pain were intensity, duration and disability.
RESULTS: Overall, the neck pain group exhibited greater AP and ML displacements, sway area and velocity in the neck torsion position on firm and soft surfaces compared to controls (partial eta squared (η²p) = 0.06-0.15, p < 0.05). The neck pain group also had greater AP displacement, sway area and velocity in the neutral position on a soft surface compared to controls (η²p = 0.09-0.16, p < 0.05). For both groups, the neck torsion position displayed overall greater postural sway compared to the neutral position (η²p = 0.16-0.69, p < 0.05). There were no relationships between the postural sway outcomes and characteristics of neck pain (p > 0.05).
CONCLUSION: The neck torsion maneuver, stimulating the receptors resulted in increased postural sway in older people, with a more pronounced effect in those with neck pain. The study provides evidence supporting the use of neck torsion for assessing impaired balance related to abnormal cervical input in older people with chronic non-specific neck pain.
The invention discloses children antimicrobial peptides cathelicidins, a preparation method and the applications thereof. The nucleotide sequence and the amino acid sequence of children antimicrobial peptides Cathelicidin1, Cathelicidin2 and Cathelicidin3 are shown as a sequence table. The preparation method of the antimicrobial peptides adopts a solid-phase chemical synthesis method or a genetic engineering method. The genetic engineering method comprises the following steps of: respectively cloning the encoding genes of mature children antimicrobial peptides Cathelicidin1-3 to expression vectors; and then, guiding into host cells to express. By applying the genetic engineering technology in the invention, the children antimicrobial peptides Cathelicidins are expressed in the prokaryotic host cells with high efficiency. Proved by experiments, the antimicrobial peptides have obvious inhibition on various gram-positive bacteria and negative bacteria.
To improve the management level of general anesthesia during bronchoscopy in the children with diffuse alveolar hemorrhage (DAH). A retrospective study was conducted in the children with DAH who had performed bronchoscopy under general anesthesia with spontaneous respiration by face mask ventilation initially from June 2021 to June 2022 in our hospital. (1) Thirty-four children who had underwent 38 bronchoscopy procedures were included. (2) General anesthesia induction was performed by bolus of propofol intravenous in all the procedures. For maintaining anesthesia, combination use of propofol and remifentanil intravenously infusion were given in 31 procedures (81.6%) and propofol intravenously infusion alone was given in the rest 7 procedures (18.4%). An intravenous bolus of ketamine or propofol was given as an anesthetic adjuvant in 21 procedures (55.3%). Thirty-five procedures (92.1%) were successfully completed under non-tracheal intubation ventilation, whereas the rest 3 procedures (7.9%) needed change to tracheal intubation ventilation. (3) Respiratory depression was found in 7 procedures (18.4%), laryngospasm was found in 2 procedure (2.6%), and bronchospasm was found in 17 procedures (44.7%). Intraoperative hypoxemia occurred in 16 procedures (42.1%). The incidence of intraoperative hypoxemia in the procedures at the active phage of disease was significantly higher compared to those at the remission phage of the disease (P < .05). Intraoperative hypercapnia also occurred in 16 procedures (42.1%). Two procedures (5.3%) were complicated by severe pulmonary hemorrhage. General anesthesia with spontaneous respiration by face mask ventilation is feasible and relatively safe for the children with DAH undergoing bronchoscopy, whereas the anesthetic protocol still needs to be improved.
Slow Transit Constipation (STC) is characterized by impaired colonic motility, but its relationship with gut microbiota remains unclear. This study investigated the correlation between specific gut microbial populations and STC, focusing on the Lactobacillus acidophilus to Lactobacillus johnsonii (A/J) ratio. We used four rat groups: Control (CON), Loperamide-induced STC (LOP), antibiotic-treated (ABX), and antibiotic plus Loperamide (ABX + LOP). Fecal samples were analyzed using 16S rRNA gene sequencing, and serum metabolites were examined through LC-MS. The LOP group showed an increased A/J ratio, while ABX and ABX + LOP groups had decreased ratios. Notably, the ABX + LOP group did not develop STC symptoms. Metabolomic analysis revealed alterations in key metabolites across groups, including changes in levels of guanidinoacetate, glycine, L-glutamine, nicotine, and nicotinate D-ribonucleotide in the LOP group, and variations in L-glutamine, L-phenylalanine, L-tyrosine, histamine, D-ornithine, and lecithin in the ABX and ABX + LOP groups. Our findings suggest a correlation between the A/J ratio and STC development, offering insights into STC pathophysiology and potential microbiome-targeted therapies.
The invention belongs to the technical field of medicines and relates to a radix salviae miltiorrhizae total phenolic acid tablet by adopting radix salviae miltiorrhizae total phenolic acid as a main drug ingredient and a preparation method thereof. The weight of the drug ingredient of the radix salviae miltiorrhizae total phenolic acid tablet is as follows: each radix salviae miltiorrhizae total phenolic acid tablet contains 10 to 500 milligrams, and the balance being auxiliary materials. The radix salviae miltiorrhizae total phenolic acid is subjected to crushing, sieving, mixing, granulation, drying and granulation, and is added with magnesium stearate for tabletting to obtain the radix salviae miltiorrhizae total phenolic acid tablet. The tablet is prepared by adopting the modern pharmaceutical preparation theory as guidance and through experimental investigation for a plurality of times. The preparation formulation has quick treatment effect, small side effect and strong pertinence. The radix salviae miltiorrhizae total phenolic acid tablet is used for aiding treatment of radix salviae miltiorrhizae total phenolic acid injection solution, simultaneously changes the administration route, and is convenient for patients to take orally.
A medicament carrier composition includes a medicament and a polymer component including a polyvinylpyrrolidone having a weight average molecular weight of at least 700,000 g/mol. The medicament carrier composition has a viscosity of from 500 to 5,000 cps at 250C, is substantially free of cellulose, and includes an auxiliary polymer. The medicament carrier composition is used to form a film that is also substantially free of cellulose. The film has a consistent thickness and size, and an increased flexibility and increased moisture resistance due to the polyvinylpyrrolidone. The medicament carrier composition is also used in a method of forming the film. The method includes the steps of providing the medicament and the polymer component. The method also includes the step of combining the polymer component and the medicament to form the medicament carrier composition. The method further includes the step of drying the medicament carrier composition to form the film.
Cesarean section rate is increasing in the world and in our country, and it might bring other problems with it. Pain, breastfeeding problems and decrease in comfort problems have high chance to happen after cesarean section. The insufficiency of pharmacological methods in reducing the problems experienced after cesarean section and having many side effects increase the using percentage tendency to non-pharmacological methods.

This study was conducted as randomized controlled study to evaluate the effect of Therapeutic Touch on acute pain and comfort level in women who delivered by cesarean section. Personal information form was used as data collection form, VAS was used to assess pain, and PPCQ was used to assess comfort. When power analysis was performed, the sample size was calculated to be at least 45 participants for each group (45 experiments, 45 controls). Experimental group received deep Therapeutic Touch by investigators two time at 10th and 40nd hours after cesarean section.
Benzodiazepine (BDZ) addiction is a widespread and multifaceted phenomenon. For many patients, especially females, the concomitant use of other drugs also increases their risk of QTc prolongation, possibly leading to complications such as seizures and even sudden death. However, the relationship between BDZ use and QTc prolongation is currently unclear. The present study aims to examine patterns of polysubstance use among a sample of Italian adults with BDZ dependence in relation with their QTc prolongation risk. We used Latent Class Analysis (LCA) on data collected from 251 inpatients of the Addiction Medicine Unit in Verona to group patients into three classes according to their substance use and their QTc prolongation risk. Results showed no significant relationship between QTc prolongation and BDZ use in any of the classes considered. We conclude that BDZs, even if used long-term and at high dosages, can be considered safe in terms of cardiovascular complications for patients.
Previously, we found that dCA1 A1-like polarization of astrocytes contributes a lot to the spatial memory deficit in methamphetamine abstinence mice. However, the underlying mechanism remains unclear, resulting in a lack of promising therapeutic targets. Here, we found that methamphetamine abstinence mice exhibited an increased M1-like microglia and A1-like astrocytes, together with elevated levels of interleukin 1α and tumor necrosis factor α in dCA1. In vitro, the M1-like BV2 microglia cell medium, containing high levels of Interleukin 1α and tumor necrosis factor α, elevated A1-like polarization of astrocytes, which weakened their capacity for glutamate clearance. Locally suppressing dCA1 M1-like microglia activation with minocycline administration attenuated A1-like polarization of astrocytes, ameliorated dCA1 neurotoxicity, and, most importantly, rescued spatial memory in methamphetamine abstinence mice. The effective time window of minocycline treatment on spatial memory is the methamphetamine exposure period, rather than the long-term methamphetamine abstinence.
The present invention relates to a Chinese medicine preparation for treating cough and asthma. The preparation comprises the prescriptions of red ginseng, astragalus root, gecko, cordyceps, radix aconiti lateralis preparata, malaytea scurfpea fruit, coked white atractylodes rhizome, barbary wolfberry fruit, herba epimedll, schisandra, white nut, white peony alba, ledebouriella root, dried orange peel, morinda root, pangolin scale, broomrape, old arable soil and oriental waterplantain rhizome. The red ginseng, the gecko and the cordyceps are weighed according to the prescriptions and ground into fine powder with 100 meshes. The rest sixteen kinds of medicine, such as the astragalus root, etc., are decocted for two times by adding water. For the first time, the water is added with the quantity of 10 times, and the decoction is carried out for 1.5 hours. For the second time, the water is added with the quantity of 6 times, the decoction is carried out for 1 hour, the filtration is carried out to obtain filtered solutions, and the filtered solutions are mixed. The filtered solutions are decompressed and concentrated into clear paste, and the spray drying is carried out to obtain fine powder. Dextrin is added according to a proper proportion and uniformly mixed with the fine powder of the three kinds of medicine of the red ginseng, the gecko and the cordyceps so as to obtain granules, and the granules are dried to obtain the preparation. The present invention has the advantages of cough relief, sputum reduction, lung strengthening, spleen strengthening and rapid effect taking. The present invention is suitable for elders and children.
PROBLEM TO BE SOLVED: To provide an aerosol preparation stable for a long period manifesting humectant effects and sufficient immediate analgesic effectivity and capable of simply spraying on a wide range of parts. SOLUTION: This aerosol preparation comprising the stock solution composed of active ingredient, humectant and base and mixing with propellant in which the stock solution includes 0.1 to 3 wt.%. of lidocaine, 0.1 to 2 wt.%. of diphenhydramine and 1 to 10 wt.%. of crotamiton and 0.1 to 10 wt.%. of glycerin as the humectant, and the viscosity of the stock solution is 1 to 10 cSt.
People with severe obesity who are scheduled to undergo either primary gastric bypass or primary sleeve gastrectomy will be recruited from the Bariatric Clinics at University College London Hospital (UCLH) and the Whittington Hospital and asked to participate in an observational cohort study. Eligible patients will be given a participant information sheet (PIS) for BARI-LIFESTYLE Observational Study and informed consent will be sought. Recruited patient will attend for 4 research visits, timed to coincide with their clinic visits, at approximately 6 weeks before surgery (Visit 1), 3 month post-surgery (Visit 2), 6 months post-surgery (Visit 3) and 12 months post-surgery (Visit 4). Each research visit will include assessment of body weight, body composition (using bioelectrical impedance analysis), physical fitness and activity levels, obesity-associated co-morbidities, HRQoL and usual care laboratory investigations. Dual energy X-ray absorptiometry (DXA) scanning will be undertaken at Visit 1 and Visit 4, which is not a usual assessment for the post-surgery standard care. All of the research assessments will be done as part of this observational cohort study.

Immediately after surgery has been undertaken, BARI-LIFESTYLE Observational Study participants will be randomised to continue to receive usual care, or usual care plus lifestyle intervention (nutritional and behavioural tele-counselling, self-monitoring and a 12-week supervised tailored exercise programme). However, to avoid contamination between the intervention group and the usual care group, only those randomly allocated to the lifestyle intervention group will be informed of this. They will be given a PIS (BARI-LIFESTYLE Intervention Study) and informed consent will be sought. If the participants decline to take part in the lifestyle programme, they will remain in the control group (observational cohort study).
PURPOSE:To obtain a system where the state of a patient is easily and minutely grasped by fetching video information for recording patient information and supplying document conversion recording information. CONSTITUTION:A camera 10 is provided in medical treatment environment so as to record treatment conditions in a storage system 1 as video information and a reproduction system 2 displays last time or related information in 20 as video information. Recording and reproducing are naturally controlled without a new burden through the operation of an electronic chart system 3 being the conventional system. A retrieving key information is added to video information by a retrieve information generating means for controlling and reproducing. The high recognition ability of humans is spontaneously utilized and the state and conditions of the patient are excessively easily grasped. This is specially effective for grasping medical treatment conditions in emergency medical treatment.
Betamethasone sodium phosphate and betamethasone acetate Injectable Suspension, USP 6 mg per mL, 3 mg per milliliter betamethasone, as betamethasone sodium phosphate, and 3 mg per milliliter betamethasone acetate. When oral therapy is not feasible, the Injectable Suspension is indicated for intramuscular use only.
Consent will be obtained for study enrollment from the patient or legal decision maker. The patient will then be randomized and stratified based on the fracture type, fixation method anticipated, and presence of anticoagulation.

Treatment drug and saline placebo will be blinded from the patient. Treatment arm patients will receive a dose of 10 mg/kg of TXA IV as soon as possible in the ED. They will then receive repeat doses prior to skin incision and again after the end of surgery. Control group will receive a placebo dose of normal saline in the ED and then the standard 10 mg/kg TXA doses prior to surgery and again after the end of surgery. The perioperative doses will not be blinded.
A composition for preventing or treating cancers comprising allspice extracts is provided to prevent or treat hormone receptor-mediated cancers such as prostate cancer. A composition for preventing or treating cancers comprising allspice extracts comprises allspice extracts. The allspice extracts are the materials extracted by water, C1-6 lower alcohol or the mixed solvent thereof or the butanol fraction of lower alcohol extracts. The composition prevents or cures hormone receptor-mediated cancers. The hormone receptor-mediated cancers are prostate cancer. The composition additionally includes a pharmaceutically allowable carrier.
Our 2022 published working definition of disease modification in systemic lupus erythematosus (SLE) was 'minimising disease activity with the fewest treatment-associated toxicities and slowing or preventing organ damage progression'. The objective of this review was to classify current SLE treatments according to the proposed non-renal disease modification criteria excluding toxicities. Based on a review of select clinical trial (n=32) and observational study (n=54) publications for 14 SLE medications across different therapeutic classes, and the authors' clinical experience, we evaluated disease modification potential as per the proposed framework at three time points. Specific criteria used to determine disease modification potential included a drug's capacity to reduce: (1) non-renal disease activity, (2) severe flares, (3) use of steroids/immunosuppressants and (4) organ damage accrual. Criteria 1-3 were assessed at 1 year and 2-5 years and, when positive, were considered evidence for disease modification potential; criterion 4 was used to confirm disease modification at >5 years. Each treatment received one of four mutually exclusive designations at each time point: (a) criterion met, (b) indications of criterion met despite insufficient evidence in the literature, (c) inconclusive and (d) no available supportive data. This review excludes an assessment of potential toxicities. Eight of the 14 SLE treatments met ≥1 disease modification criteria up to year 5. Hydroxychloroquine improved overall survival at >5 years, suggesting long-term disease modification, but no data on specific organ systems were reported. Belimumab was the only treatment to meet all criteria. Belimumab and hydroxychloroquine met disease modification definitions across three time points. Evidence for other SLE therapies was incomplete, particularly at >5 years. Future studies are warranted for other treatments to meet the disease modification criteria. We discuss challenges to classification and possible updates to our published criteria.
FIELD: pharmaceutical industry. SUBSTANCE: present invention describes pyrrolidine derivatives of formula 1:   wherein R 1  is heteryl(lower)alkyl, (C 1 -C 12 ) alkyl and optionally substituted phenyl (lower) alkyl; R 2  is H, phenyl (lower)alkoxycarbonyl or optionally substituted phenylsulphonyl; R 3  is carboxy (lower) alkyl, etherified carboxylower alkyl, carboxyphenyl or etherified carboxyphenyl and pharmaceutically acceptable salts thereof. Said salts are prepared by reacting compound of formula II:   with compound of formula XIV:   or salt thereof. Present invention describes pharmaceutical composition which has antagonistic activity against thromboxane A 2 (TXA 2 ) and inhibits TXA 2  synthase based on compound I. EFFECT: improved properties of the pharmaceutical composition. 9 cl