anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
An herbal remedy to asthma comprising a weighed proportional mixture of Sunnut honey and powder of ground seeds of Solarium dubium. Separation and isolation of active compounds from the methanolic extract of combination was carried out using bioassay-guided fractionation. The in-vivo experiments were implemented to assess the toxicological study of the crude and methanolic extracts of the combination, honey and the seeds. The results revealed that there is no acute or sub-chronic toxicity displayed by the different concentrations of the extracts. The method of Carrageenan induced paw edema in Wister Rats was done to evaluate the anti-inflammatory effects of aqueous crude extract of S. dubium seeds, honey and combination. The results showed that all ingredients were found to have a significant anti inflammatory activity on paw edema volume. Also the result of methanolic extracts showed a significant inhibition of inflammation, As a clinical trial for the combined ingredients, twenty five patients medically diagnosed as asthmatic were randomly selected and enrolled in the study; none of them is currently using anti-asthmatic drugs. Signs of asthma disappeared in the treated patients.
Adults: The recommended initial dosage in adult patients is 800 mg/day. In clinical studies, the average dosage was about 1,000 mg/day. 

Pediatrics: The recommended initial dosage in pediatric patients weighing 20 kg and greater is 15 mg/kg/day. Avoid dosages greater than 50 mg/kg per day in pediatric patients [see Warnings and Precautions ( 5.1), Use in Specific Populations ( 8.4)] . 

Administer THIOLA EC in 3 divided doses at the same times each day, with or without food. Maintain a routine pattern with regard to meals.

Consider starting THIOLA EC at a lower dosage in patients with history of severe toxicity to d-penicillamine.
The intervention consisted of walking, jogging or running for \~ 15 min (\~ one mile) of exercise at a pace self-selected by each individual child, outside the school buildings during recess time, three times a week during 10 weeks. Children were instructed to maintain active for the full 15 min and, if necessary, to stop for resting only occasionally.
FIELD: organic synthesis. SUBSTANCE: 9- aminocamptotecine with formula I (presented in description) is prepared by reaction of compound depicted by formula III, wherein hydroxy group of ring A is located in position 10 or 12, with nitration agent to form corresponding compound IV. The latter is further converted into compound V in which XO is a group replaceable upon hydrogenation. Next step of reaction consists in reductive removal of group XO and simultaneous reduction of nitro group in compound V to give final product (I). Compounds of formulas V and VII exhibit antitumor activity. EFFECT: simplified process and reduced expenses. 15 cl, 21 ex
The present disclosure relates to a system, method, and computer program for predicting migraines using machine learning. More specifically, the system predicts the likelihood that a user will have a migraine within a certain period of time (e.g., a month) based on migraine causes/triggers X 1 . . . n  identified from a migraine pattern built using deep neural networks. The system collects data from the user with respect to his/her profile, his/her migraine incidents (having experienced a migraine or not) and his/her daily habits. Based on these data, it creates the user's migraine pattern and combines this pattern with the migraine patterns from similar users (when necessary). As a result, it is able to predict the probability of getting a migraine within a period of time.
1,141,821. Medicinal polysaccharides. TOHOKU YAKULT SEIZO K.K. 12 April, 1967 [20 April, 1966], No. 16794/67. Heading A5B. [Also in Division C3] Nitrogen-containing polysaccharides are extracted from unicellular green algae by successively extracting the algae under the action of heat with (i) a hydrophilic organic solvent or a mixture thereof and water, (ii) water, (iii) an alkaline aqueous solution and (iv) an acidic aqueous solution to produce four separate extracts; concentrating these extracts and removing the hydrophilic solvent and alkaline and acidic substances from their respective extracts; forming a precipitate of impurities by adding ethanol to each extract until the ethanol concentration reaches about 80% and removing the precipitates and added ethanol; and finally forming a white precipitate of the desired polysaccharides by adding absolute ethanol to each extract, and recovering the precipitates. The hydrophilic solvent may be methanol, ethanol or acetone. NaOH and H 2 SO 4  respectively are specified as the alkali and the acid. The product has use in stimulating activity of the reticulo-endothelial system. In an example, a rat is injected with a polysaccharide as above, and the increased removal rate of carbon particles previously injected into the bloodstream is noted.
Patients are randomly assigned to the Random Allocation group and then randomly assigned to receive open-label escitalopram (10-20 mg/d) and blinded brexpiprazole (0.5-2 mg/d) for the first 8 weeks of the study. For the final 4 weeks of the study, patients will continue to receive both medications but the brexpiprazole will no longer be blinded.
All women seeking surgical abortion before 12 weeks of pregnancy will be invited to participate in the study. We will include 400 patients. Written consent is given. Pain is measured on a VAS-scale (1-10) 2 hours post operatively and repeated 2 days postoperatively. Nausea is categorized in 4 groups, from 1 (no nausea) to 4 (pronounced nausea with vomiting)and is registered together with bloodloss also during the hospital stay (2 hours) and 2 days postoperatively. The two groups will be compared.
OBJECTIVE: Maximal safe resection of gliomas near motor pathways is facilitated by intraoperative mapping. Here, the authors review their results with triple-modality asleep motor mapping with motor evoked potentials and bipolar and monopolar stimulation for cortical and subcortical mapping during glioma surgery in an expanded cohort.
METHODS: This was a retrospective analysis of patients who underwent resection of a perirolandic glioma near motor pathways. Clinical and neuromonitoring data were extracted from the electronic medical records for review. All patients with new or worsened postoperative motor deficits were followed for at least 6 months. Regression analyses were performed to assess factors associated with a persistent motor deficit.
RESULTS: Between January 2018 and December 2021, 160 operations were performed in 151 patients with perirolandic glioma. Sixty-four patients (40%) had preoperative motor deficits, and the median extent of resection was 98%. Overall, patients in 38 cases (23.8%) had new or worse immediate postoperative deficits by discharge, and persistent deficits by 6 months were seen in 6 cases (3.8%), all in patients with high-grade gliomas. There were no new persistent deficits in low-grade glioma patients (0%). The risk factors for a persistent deficit included an insular tumor component (OR 8.6, p = 0.01), preoperative motor weakness (OR 8.1, p = 0.03), intraoperative motor evoked potential (MEP) changes (OR 36.5, p < 0.0001), and peri-resection cavity ischemia (OR 7.5, p = 0.04). Most persistent deficits were attributable to ischemic injury despite structural preservation of the descending motor tracts. For patients with persistent motor deficits, there were 3 cases (50%) in which a change in MEP was noted but subsequent subcortical monopolar stimulation still elicited a response in the corresponding muscle groups, suggesting axonal activation distal to a point of injury.
CONCLUSIONS: Asleep triple motor mapping results in a low rate of permanent deficits, especially for low-grade gliomas. Peri-resection cavity ischemia continues to be a significant risk factor for permanent deficit despite maintaining appropriate distance for subcortical tracts based on monopolar feedback.
A multicenter, prospective, open, randomized cohort, non controlled phase II clinical study to evaluate the effectiveness and safety of Darxil combined with Exemestane+goserelin neoadjuvant endocrine therapy in HR positive and HER2 negative premenopausal breast cancer patients. The study object was to evaluate the HR positive and HER2 negative premenopausal breast cancer patients with SD after 2 cycles of neoadjuvant chemotherapy. The main endpoint was the objective response rate (ORR) of treatment。Objective: To evaluate the efficacy and safety of darsilide combined with endocrine therapy in SD patients with HR positive and HER2 negative premenopausal breast cancer after 2 cycles of neoadjuvant chemotherapy. It is planned to recruit 119 HR positive and HER2 negative premenopausal breast cancer patients in Group A to conduct the trial with Simon's two-stage design. The null hypothesis is a true response rate of 0.2, while the alternative hypothesis is a true response rate of 0.4. The experiment was conducted in two stages. In the first stage, 13 patients were enrolled. If there are ≤ 3 responses in 13 patients, the study will be stopped Early stopping. Otherwise, continue30 patients were enrolled, with a total sample size of 43. If there are ≥ 13 patients responding, the treatment is effective. Group B was randomly assigned in a 1:1 ratio, with the same number of participants as Group A, resulting in 43 final participants. Calculated based on the proportion of SD patients in 2 cycles of neoadjuvant chemotherapy accounting for 80%, and considering a 10% dropout rate, the final enrollment was made The sample size is 119 cases. The actual samples for molecular testing can be randomly selected based on clinical efficacy, with a statistically significant number.
The present invention relates to a kit for predicting the curative effect of a hypotensor, a method and a composite medicine, particularly a method for predicting the curative effect of ACEI hypotensors by testing the polymorphic site genotype of functional genes and the application of the method. The kit contains a primer, a restriction enzyme Hae III and a restriction enzyme buffer solution 2. The method comprises: qualitatively predicting the curative effect of ACEI hypotensors by testing the Asp919Gly polymorphic site genotype of MS genes in high-cysteine path of tested patients. By using the test results of the genotype as parameters, after the parameters are combined with other basic physiological parameters and special parameters to be calculated by computer languages, a quantitative value with accurate predicting results for blood pressure decrease can be obtained. The method can be applied to a group of composite medicines which can enhance the curative effects of ACEI hypotensor. The present invention has the advantages for providing convenience for doctors to select medicines according to individual difference, increasing the efficiency and safety of clinical medication and therapy, and reducing the risk of toxic side effects and economic burdens.
PROBLEM TO BE SOLVED: To obtain a cosmetic capable of stably compounding a quercetin glycoside also with cosmetic, especially having high water content and capable of sufficiently exhibiting elimination of active oxygen and ultraviolet ray- absorbing effect by compounding the quercetin glycoside as a specific clathrate compound. SOLUTION: This cosmetic comprises a clathrate compound of quercetin or/and quercetin glycoside with cyclodextrin or/and a cyclodextrin-containing starch decomposed material. A cyclodextrin selected from β-cyclodextrin, γ- cyclodextrin, β-branched cyclodextrin, γ-branched cyclodextrin is used as the cyclodextrin. Rutin is preferably used as the quercetin glycoside. A compounding amount of the active ingredient is 0.0001-100wt.% based on the cosmetic composition. The cosmetic can be utilized as a basic cosmetic, a hair cosmetic, etc.
Alcohol and substance use disorders are more common in bipolar disorder bipolar disorder than in any other DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) Axis I disorder, estimated to occur in up to 60% of patients with bipolar disorder. Alcohol use is associated with poor outcome in bipolar disorder, and yet these co-occurring conditions are understudied. To date, there is only one published placebo-controlled trial of an agent for the treatment of alcohol dependence alcohol dependence in bipolar disorder. The purpose of the proposed study is to evaluate the efficacy of a topiramate as a treatment for alcohol dependence in patients with bipolar disorder. This is a 12-week, randomized, placebo-controlled study of the efficacy of topiramate adjunctive to standard treatment for bipolar disorder in patients with alcohol dependence and bipolar disorder. Additional aims of the study are to document the safety and tolerability of topiramate in this population, and to evaluate to effect of decreased drinking on mood symptoms. The study involves the enrollment of a total of 80 patients with co-occurring alcohol dependence and bipolar disorder over the course of 40 months at the Massachusetts General Hospital (MGH) Bipolar Clinic and Research Program (BCRP) (www.manicdepressive.org). With a conservative estimate of a 30% dropout rate, approximately 56 of the 80 patients with these two comorbid conditions will complete 12 weeks treatment with either topiramate or placebo.
Dietary soy protein and soy isoflavones have anti-inflammatory properties. Previously, we reported that feeding soy protein concentrate diet (SPC) with low or high isoflavone (LIF or HIF) to young (seven-week-old) obese (fa/fa) Zucker rats inhibits lipopolysaccharide (LPS) translocation and decreases liver inflammation compared to a casein control (CAS) diet. The current study investigated whether SPC-LIF and SPC-HIF diets would reduce liver inflammation in adult obese Zucker rats fed a CAS diet. A total of 21 six-week-old male obese (fa/fa) Zucker rats were given CAS diet for 8 weeks to develop obesity then randomly assigned to CAS, SPC-LIF, or SPC-HIF (seven rats/group) diet for an additional 10 weeks. The expression of LPS-translocation, inflammation, and intestinal permeability markers were quantified by qPCR in liver, visceral adipose tissue (VAT), and colon. LPS concentration was determined in both the colon content and fecal samples by a Limulus amebocyte lysate (LAL) test. SPC-LIF and SPC-HIF diets significantly decreased liver LPS-binding protein (LBP) expression compared to CAS diet (p < 0.01 and p < 0.05, respectively). SPC-HIF diet also significantly decreased liver MCP-1 and TNF-α expression (p < 0.05) and had a trend to decrease liver iNOS expression (p = 0.06). In the colon, SPC-HIF diet significantly increased LBP expression compared to CAS diet (p < 0.05). When samples from all three groups were combined, there was a negative correlation between colon LBP expression and liver LBP expression (p = 0.046). SPC diets did not alter the expression of intestinal permeability markers (i.e., occludin, claudin 3, and zonula occludens-1) in the colon or inflammation markers (i.e., TNF-α and iNOS) in VAT or the colon. LPS levels in the colon content did not differ between any groups. Fecal LPS levels were significantly higher in the SPC-LIF and SPC-HIF groups compared to the CAS group (p < 0.01). In conclusion, SPC, particularly SPC with HIF, reduces liver LBP expression and inflammation makers (i.e., TNF-α and MCP-1 expression) in adult obese Zucker rats, likely by reducing LPS translocation.
BACKGROUND: The gut-brain axis may mediate mood changes due to strenuous exercise. Therefore, probiotic supplementation may mitigate mood worsening.
PURPOSE: The present study aims to evaluate the effect of probiotic supplementation on mood and immunometabolic parameters after a marathon.
MATERIALS AND METHODS: Fourteen marathon runners were selected and divided into placebo and probiotic groups that were supplemented for 30 days. Before and after the marathon, mood (POMS) was assessed, and blood was collected for analysis of immunometabolic parameters. Statistical analysis was performed, and p < 0.05 was considered to determine statistically differences.
RESULTS: Tension decreased after the marathon in both groups. Vigor decreased only in the placebo group. Fatigue increased after the marathon in both groups. TMD increased after the marathon in placebo. The IL2/IL-4 ratio decreased in the probiotic group after the marathon compared to before and increased compared to the placebo group. The IL-10 increased after the marathon in placebo. TNF-α increased after the marathon in probiotics. The TNF-α/IL-10 ratio decreased after the marathon in both groups. LPS decreased in the probiotic group after the marathon compared to before and in the placebo group.
CONCLUSIONS: Thirty days of probiotic supplementation attenuated the impact of marathons on mood worsening. The decrease in LPS in the probiotic group mediated the change in the pro/anti-inflammatory balance, indicating an immunometabolic mechanism by which the gut-brain axis impacts mood after strenuous exercise.
PURPOSE:To immobilize a physiologically active substance in high immobilization efficiency simply and firmly, by polymerizing a glassy supercooled polymerizable monomer at low temperature by light ray or ionizing radiation irradiation to give a porous polymer, bringing the polymer into contact with a physiologically active substance to adoserb the substance on the polymer, and drying the polymer. CONSTITUTION:A glassy supercooled polymerizable monomer[e.g., hydroxyethyl methacrylate, etc.] is blended with water, irradiated with light rays or ionizing radiation at low temperature <=0 deg.C and polymerized, to give a porous polymer. Then, it is added to an aqueous solution of a physiologically active substance (e.g., glucoamylase, etc.), it is in contact with the solution for a given time, so that the physiologically active substance is absorved in or adsorbed on the polymer, and the polymer is dried, so that the physiologically active substance is immobilized to the polymer. The concentration of the monomer in water is preferably 5-90wt%.
Participants randomized to the No-treatment Control group completed a 3-month No-treatment Period. Participants were then eligible to receive optional treatment with JUVÉDERM® VOLBELLA™ XC injectable gel injected into the infraorbital and adjacent area followed by an optional touch-up treatment 1 month later.
The invention relates to a medicament for controlling swine fever, which consists of the following components in part by weight: 0.1 to 0.5 part of moroxydine, 0.5 to 1.5 parts of bezoar antitoxic bolus, 3 to 11 parts of weeping forsythiae, 1 to 8 parts of golden thread, 5 to 14 parts of licorice, 1 to 7 parts of bupleurum, and 2 to 12 parts of amur corktree bark. In the medicament, the moroxydine has an inhibitory action on a plurality of viruses such as influenza virus, parainfluenza virus, rhinovirus, corona virus, adenovirus and the like. Calculus bovis artifactus has an effect of allaying a fever and resisting inflammation. The weeping forsythiae has an effect of resisting bacteria. The golden thread has an effect of detoxifying. The licorice is neutral in nature and sweet in taste, acts on twelve regular channels, and has pharmacological effects of detoxifying, eliminating phlegm, relieving pains, relieving spasm or even resisting cancer and the like. The medicament has the principle indications of dispersing to allay a fever, and invigorating vital functions to soothe the liver, and is used for treating cold fever, alternate attacks of chills and fever, malaria, stagnation of qi due to depression of the liver, and sternal rib swelling pain. The medicament can enhance the immunity of a pig and the disease resistance of the pig, and can effectively control the swine fever.
Insufflation of an arterial pressure cuff located in one upper extremity, during 4 cycles, each with a duration of 5 minutes insufflation and 5 minutes of disinflation. The cuff will be insufflated to reach 10 mmHg above the diastolic arterial pressure of the patient.
NEW MATERIAL:A tetrapeptide derivative of formula I (R1 is H or lower alkyl; R2 is H or side chain of D-alpha-amino acid; R3 is H or lower alkyl; X is O or S) and a salt thereof. EXAMPLE:H-Tyr-(D)-Met(O)-Gly-Mephe-NHNHCONH2. USE:An analgesic agent and remedy for gastroenteric disorder, e.g. diarrhea, having an inhibitory action on gastroenteric movement and a psychotripic action expectable. Sufficent analgesic effects can be exhibited even by intravenous injection and subcutaneous administration as opposed to enkephaline, etc. PROCESS:The protecting group removed from a compound of formula II (Y1 is protecting group; Y2 is H or protecting group; R2' is H or side chain of D-alpha-amino acid which may have a protecting group) to give the compound of formula I.
The role of the gut microbiota in energy metabolism of the host has been established, both in overweight/obesity, as well as in undernutrition/stunting. Dysbiosis of the gut microbiota may predispose to stunting. The aim of this study was to compare the gut microbiota composition of stunted Indonesian children and non-stunted children between 36 and 45 months from two sites on the East Nusa Tenggara (ENT) islands. Fecal samples were collected from 100 stunted children and 100 non-stunted children in Kupang and North Kodi. The gut microbiota composition was determined by sequencing amplicons of the V3-V4 region of the 16S rRNA gene. Moreover, fecal SCFA concentrations were analyzed. The microbiota composition was correlated to anthropometric parameters and fecal metabolites. The phyla Bacteroidetes (Bacteroidota; q = 0.014) and Cyanobacteria (q = 0.049) were significantly higher in stunted children. Three taxa at genus levels were consistently significantly higher in stunted children at both sampling sites, namely Lachnoclostridium, Faecalibacterium and Veillonella (q < 7 * 10-4). These and 9 other taxa positively correlated to the z-score length-for-age (zlen), while 11 taxa negatively correlated with zlen. Several taxa also correlated with sanitary parameters, some of which were also significantly different between the two groups. All three fecal SCFA concentrations (acetate, propionate and butyrate) and their total were lower in stunted children compared to non-stunted children, although not significant for butyrate, indicating lower energy-extraction by the gut microbiota. Also, since SCFA have been shown to be involved in gut barrier function, barrier integrity may be affected in the stunted children. It remains to be seen if the three taxa are involved in stunting, or are changed due to e.g. differences in diet, hygiene status, or other factors. The observed differences in this study do not agree with our previous observations in children on Java, Indonesia. There are differences in infrastructure facilities such as clean water and sanitation on ENT and Java, which may contribute to the differences observed. The role of the gut microbiota in stunting therefore requires more in depth studies. Trial registration: the trial was registered at ClinicalTrials.gov with identifier number NCT05119218.