anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a memantine hydrochloride oral-dissolving film preparation. The preparation shields a stimulated flavor and is good in appearance. The memantine hydrochloride oral-dissolving film preparation comprises, by weight, 30-50% of memantine hydrochloride, preferentially, 30-40% of memantine hydrochloride, 35-55% of macromolecule film-forming materials, 3.0-15% of flavor corrective, 2-20% of plasticizers and 0-5% of other auxiliary materials. The other auxiliary materials comprise one or two of pigment and flavoring agents. Through increasing the content of the raw material chemicals, selecting the appropriate flavor corrective and the film-forming materials and controlling the grain size of the raw material chemicals, the film preparation free of the stimulated flavor, smooth in surface, even in content of chemicals, high in disintegration speed and rapid in absorption is obtained; the film preparation is convenient to take and improves the compliance of a patient. The invention further provides a method of preparing the film preparation and an application of the film preparation in treating the Alzheimer disease.
Arthrofibrosis after anterior cruciate ligament reconstruction can become a major complication requiring surgical intervention. The reported incidence approximates 8% but varies widely (2%-35%) and, as not all patients require surgery, may be underreported. Several risk factors are involved. Female sex, older age, surgery within the first month after injury, and meniscus repair are consistently associated with increased risk. Other factors include graft size and type, concomitant procedures, use of anticoagulants, and genetic factors. By identifying risk factors, we can modify our surgical technique and rehabilitation to meet each patient's needs with fewer complications.
A method for identifying a microbial composition that inhibits colonization of an enteric pathogen of a first animal is disclosed. The method includes removing a microbial sample from the digestive tract of a second animal. The method further includes culturing the microbial sample, isolating, cultivating and identifying microbial species within the microbial sample. The method further includes creating compositions of one or more isolated microbial species and determining the ability of the composition to inhibit growth of an enteric pathogen in at least one of an in vitro or an in vivo assay. The method further includes identifying a microbial composition capable of inhibiting growth of enteric pathogens in a first animal. A microbial composition that inhibits colonization of an enteric pathogen of a first animal is also disclosed. The composition includes microorganisms from a group comprising Faecalicoccus, Laciobaciiius, Megamonas, Staphylococcus, Bacillus, Enterococcus, Olsenella, Megasphaera, Pseudoflavonifractor, and Massiliomlcrobiota.
OBJECTIVE: This study aimed to test whether palmaris longus tendon (PLT) length and thickness can be predicted from simple anthropometric measurements.
MATERIALS AND METHODS: 120 healthy volunteers with bilateral PL muscles were enrolled in this prospective study. PLT length and thickness were measured by ultrasonographic examination. Anthropometric measurements included body height, weight, forearm length, and wrist circumference. Correlation, linear regression, and Bland-Altman plot were used for analysis.
RESULTS: The mean PLT length and thickness were 10.8±1.4 cm and 4.0±0.9 mm, respectively. Body height and PLT length had a moderate positive correlation (r:0.407, p:0.001), and forearm length and PLT thickness had a weak positive correlation (r:0.229, p:0.001). The regression analysis showed that body height was the best predictor for PLT length, and forearm length was the best predictor for PLT thickness. The regression equations were as follows: PLT length=0.276+(0.062×height) (r2=0.165, p<0.001) and PLT thickness=1.373+(0.108×forearm length) (r2=0.052, p<0.001). The predicted PLT lengths and thicknesses were calculated using these regression formulas and compared with the actual thicknesses and lengths using the Bland-Altman plot. The upper and lower limits of agreement (95% CI) ranged from -2.54 cm to 2.51 cm for actual PLT length and predicted PLT length and from -1.76 mm to 1.74 mm for actual PLT thickness and predicted PLT thickness in the Bland-Altman plot with a weak agreement and proportional bias.
CONCLUSIONS: These findings indicate that height and forearm length have limited accuracy in predicting PLT length and thickness. The preoperative ultrasonographic examination can provide valuable assistance, particularly in cases that require grafts with precise length and thickness requirements.
FIELD: medicine, reanimatology, surgery, pathological physiology. SUBSTANCE: invention relates to the use of gelatin aqueous solutions or agar-agar for evaluation of manifestation of endotoxemia and degree of disease severity. Method is based on estimation of temperature shifting transient point "sol-gel" for gel-forming biological substances. The developed agent provides to carry out quantitative determination of degree and severity of manifestation of endotoxemia. EFFECT: enhanced effectiveness of agent, improved method of evaluation. 1 tbl
BACKGROUND: To investigate impact of frozen elephant trunk (FET) on long-term distal aortic remodeling in acute A aortic dissection (AAD) according to the latest recommended standards from the Society for Vascular Surgery (SVS)/Society of Thoracic Surgeons (STS).
METHODS: Clinical data and imaging of patients who underwent FET to treat acute AAD over the last 8 years were retrospectively reviewed. Patients were included if a pre and postoperative computed angio tomographies at least 30 days from surgery was available for comparison. Contrasted postprocessed imaging were analyzed with Aquarius iNtuition (TeraRecon Inc., Foster City, CA, USA) to analyze long-term positive aortic remodeling, false lumen thrombosis, and aortic expansion according to the SVS or STS recommendations. Secondary endpoints were the rate of in-hospital and long-term mortality, spinal cord ischemia (SCI), and aortic-related reinterventions.
RESULTS: Out of 75 patients who underwent FET for type A AAD, n = 41 (54.6%) were included. Significant positive aortic remodeling was reported in Ishimaru zone 1-4 but not in visceral or infrarenal aorta (P < 0.001), and the overall rate of false lumen thrombosis was 95.1% (n = 39). Aortic expansion rates were as follows: 4.9% in zones 1-4, 8.3% in zones 5-6, and 15% in zone 7. The rates of in-hospital mortality and long-term mortality were 7.3% (n = 3) and 9.7% (n = 4), respectively. At a median follow-up of 11 months (range 1-141, reintervention rate was 17.1%.
CONCLUSIONS: We report positive aortic remodeling of the distal thoracic aorta in patients who underwent FET for acute AAD according to the SVS or STS reporting standards. The positive effect on the distal aorta is limited to the thoracic segments but not in the visceral aorta.
The newly developed portable oxygen concentrator with an auto-demand oxygen delivery system (auto-DODS) automatically switches between 3 sensitivities according to the negative pressure gradient of inhalation and supplies oxygen only during inhalation. The aim of this study was to verify the effectiveness and safety of auto-demand devices compared with a continuous flow oxygen concentrator, during sleep, in a randomized crossover noninferiority trial. We alternatively used an auto-DODS or a continuous-flow oxygen concentrator, all night on separate days for HOT (Home Oxygen Therapy) patients with nocturnal hypoxemic symptoms. The primary endpoints were the mean value of oxygen saturation (SpO2) over the total sleep time. The secondary endpoints included the efficacy endpoints and the safety endpoints. Regarding the primary endpoint, the difference in SpO2 between the auto-DODS and continuous flow was 0.835%. Since the upper limit of this difference did not exceed 2.8, which was set as the noninferiority margin, it was shown that the auto-DODS did not reduce SpO2 by at least 2.8% on average compared to continuous flow. No equipment failure or exacerbation of disease was observed, confirming the safety of the auto-DODS during the night.
1457034 Filter media A M F INC 29 April 1974 [9 May 1973] 18580/74 Heading B1D A filter medium is mixed with colloidal melamine-formaldehyde cationic resin to give it a positive zeta potential and thereby enable it to retain sub-micron particles by Van der Waal's forces. The filter medium may be a mat of glass fibres of 0.05 to 1 micron diameter, possibly mixed with cellulose fibres to act as a binder, or diatomaceous earth with pores less than 5 microns dia., or fibrous polyacryloritrile or polypropylene of 1 micron dia., or a bed of sand or glass particles several feet thick. Di or trimethylolmelamine resins are preferred. The media are mixed with water and resin and then separated from the mixture with the resin adhering to them. The mat is formed by filtering the mixture through a screen tray. The final medium contains 3-50% resin based on the other solids. Filtering properties similar to those of asbestos are obtained without the associated health risks when used to filter wine and spirits.
A system of monitoring depression in a user, uses a computer system. The system initially calibrates, to determine baseline information about the user for each of a plurality of different categories of action of the user and continues learning about the user to make minor adjustments to prescribed behaviors and therapies. The categories can include sleep, diet, screen time, exercise, social interaction, medication compliance, and academic performance. The computer system uses the baseline information to determine user behavior, for each of the different categories that is correlated with likely behavior associated with depression. After initially calibrating, the computer system operates to monitor each of said different categories of action of the user and compares the monitored categories with the baseline information to determine whether the user is complying by acting within specified parameters within each category. The system can provide positive reinforcement and alerts.
BACKGROUND: We developed a Rare Cell Sorter (RCS) for collecting single cell including circulating tumor cells (CTCs). This single-institution pilot study evaluated the ability of this device to detect tumor-like cells in patients with lung cancer and confirmed their genuineness based on the epidermal growth factor receptor (EGFR) mutation concordance with tissue samples.
METHODS: This study included patients treated for lung cancer from September 2021 to August 2022 in University of Tsukuba Hospital. Peripheral blood samples were obtained before surgery or during periodic medical checks for patients treated with drugs. We used the RCS to capture cells based on size. The cells were stained, and the Hoechst-positive, CD45-negative, and epithelial celladhesion molecule (EpCAM)- positive cells were defined as CTCs, were collected. The presumptive CTCs were counted and tested using digital droplet polymerase chain reaction for EGFR mutations and compared with the tissue EGFR status to check concordance.
RESULTS: Eighteen patients were included in this study and CTCs were detected in 6 patients (33%). The CTCs from three patients showed EGFR mutation, and the EGFR mutation status of CTCs concorded with that of tissue samples in 83% of the cases (5/6). Only one CTC showed a different status from the tissue, and the concordance rate of EGFR status between CTCs and the tissue was 96% (24/25).
CONCLUSION: The ability of the RCS to detect CTCs in patients with lung cancer was demonstrated based on the concordance of EGFR status in this pilot study. This novel hybrid method of CTC recovery using the RCS has the potential to recover a wide range of CTCs regardless of EpCAM. Further validation through a large-scale study is needed.
Participants will receive medically tailored groceries (10 meals per person in the household per week from enrollment to 4 weeks after delivery) high in micronutrients that are delivered to their homes weekly. They will also interact weekly with their assigned Community Health Worker to address social needs and patient-centered goals.
The association of scaling and root planing (SRP) with systemic metronidazole (MTZ) and amoxicillin (AMX) has been advocated as one of the most promising therapeutic protocol for the treatment of advanced periodontitis, since the early 2000's. More recently, probiotics has also been suggested as a promising adjunctive treatment for periodontitis due to their antimicrobial and anti-inflammatory properties. Therefore, the aim of this study is to evaluate the clinical, microbiological and immunological effects of probiotics as an adjunct to SRP alone or in combination with MTZ and AMX in the treatment of periodontitis. In this randomized, double-blind, placebo-controlled trial, subjects with periodontitis will be randomly assigned to receive (i) SRP alone, or combined with: (ii) two probiotics lozenges a day for 90 days (Prob), (iii) 400 of MTZ, plus AMX (500 mg) thrice a day (TID) for 14 days (MTZ+AMX), or (iv) Prob and MTZ+AMX. Subjects will be monitored up to 1 year post-therapy. Nine subgingival plaque samples will be collected at baseline and at 3, 6 and 12 months post-therapy; three samples in each of the following pockets categories: shallow (probing depth \[PD\]≤3 mm), moderate (PD=4-6 mm) and deep (PD≥7 mm). The microbiological samples will be analyzed by checkerboard DNA-DNA hybridization for 40 bacterial species. Two non-contiguous diseased sites (i.e PD and CAL ≥ 5mm, bleeding and probing \[BOP\] and no furcation involvement) and two non-contiguous healthy sites (i.e. PD and clinical attachment level \[CAL\] ≤ 4 mm without BoP and/or marginal bleeding) will be randomly chosen per patient for gingival crevicular fluid (GCF) sampling, from the same sites selected for the microbiological monitoring. Peripheral blood samples will also be collected one week after clinical examination. The GCF and blood samples will be analyzed using a multi-analyte method by means of a 17-multiplex fluorescent bead-based immunoassay for 17 cyto/chemokines. The significance of differences over the course of the study will be sought using repeated measures ANOVA and Tukey multiple comparison tests, and at each time point (among groups) using either ANOVA and Tukey multiple comparison tests or ANCOVA with adjustments for the baseline values. The Chi-square test will be used to compare the differences in the frequency of gender, and to compare the differences in the frequency of subjects achieving the clinical endpoint at 1 year and of self-perceived adverse effects. A stepwise forward logistic regression analysis will be performed in order to investigate the impact of predictor variables on the clinical endpoint for treatment, i.e., "presence of ≤4 sites with PD≥5 mm at 12 months post-therapy (yes/no)". The Number Needed to Treat (NNT) with adjunctive antibiotic in order to obtain treatment success (≤4 sites with PD ≥5 mm) will be calculated. The level of significance will be set at 5%.
C. madagascariensis, an unexplored species of Burseraceae is used by local population for the management of inflammation and throat pain. The disease alleviation by this plant could be due to the presence of rich repository of active compounds with various pharmacological importances. In this study, therefore, the profiling of metabolites and isolation of active compounds of C. madagascariensis was performed. Furthermore, the ethanol, ethyl acetate extracts and a selected active compound was subjected for in vitro and in vivo anti-inflammatory activities. Metabolomic analysis identified and quantified 116 metabolites from leaves, young stem and gum-resins of C. madagascariensis (Burseraceae) followed by multivariate PCA analysis. NMR, GC-MS and HPLC were used to analyze primary and secondary metabolites. Subsequently, five main isolated compounds were identified as trimethoxy tetrahydrobenzo dioxolo isochromene (TTDI), butyl phenol, butyl propionate phenol, germacrone and β-elemenone. Amongst them, TTDI was found to be a novel compound. Hence, a process was developed to obtain the enriched fraction of TTDI in ethanol and ethyl acetate extracts of leaves. Furthermore, TTDI and extracts were subjected for their in vitro anti-inflammatory activity in LPS sensitized murine splenocytes. The results showed that TTDI and both extracts significantly suppressed the levels of pro-inflammatorycytokines (TNF-α, IFN-γ). Interestingly, the suppression of pro-inflammatory cytokines was evenmore significant by the similar concentration of TTDI when compared with colchicine. However, the level of anti-inflammatory cytokine (IL-10) was found to be unchanged. Additionally, in vivo anti-inflammatory study revealed a significant reduction in carrageenan induced paw edema by TTDI and both the extracts. In the docking study, TTDI was more active than colchicine with strong binding affinity to COX-2, PLA2, and 5β reductase. Our results highlighted that the presence of metabolites with medicinal and nutraceutical importance in C. madagascariensis, could provide opportunities for the development of a new plant-based therapeutics for inflammation.
A computing device, system, method and machine readable medium for managing beds of a healthcare facility is provided. A system includes a client device and a server computing device. The client device may generate a request to assign a bed to a patient, present a list of beds to assign the patient, and receive a selection that identifies a bed of the list of beds. The server computing device may generate the list of beds presented by the client device in response to the request. The server computing device may retrieve an electronic medical record for the patient, and obtain healthcare attributes for the patient from the electronic medical record. The server computing device may generate the list based upon capabilities of a plurality of beds and the healthcare attributes of the patient retrieved from the electronic medical record. The server computing device may further assign to the patient the bed identified by the selection.
PURPOSE: To obtain the beads capable of surely transporting various components effective to a fish body such as vitamin C to environmental water without scattering and losing and improving flesh and disease resistance in extremely high efficiency. CONSTITUTION: This beads for administering active ingredients for fishes contains active ingredients for fishes. The beads further can contain a feed attracting component. The active ingredients are various nutrient auxiliaries and/or medicines. Vitamins, highly unsaturated fatty acids and astaxanthin are cited as the nutrient auxiliaries. Antibiotics and vaccines are cited as the medicines. The active ingredients may be substances having low acid polymer. The main component of the beads is a natural polymer gelatinizing agent such as alginic acid, gelatin, pectin, chitosan and gum.
Participants in this arm will receive a herbal capsule formulation, called LLP-01, consisting of 2 capsules taken once daily without food for 60 days. The capsules contain extracts from naturally occurring plant species, including Withania somnifera, Rosmarinus officinalis, Curcuma longa, Cotinus coggygria, Panax ginseng, Cordyceps militaris, Camellia sinensis, Cotinus coggygria, and Piper nigrum.
PURPOSE OF REVIEW: Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular disease. Epithelial sodium channel (ENaC) plays a critical role in renal electrolyte and volume regulation and has been implicated in the pathogenesis of SSBP. This review describes recent advances regarding the role of ENaC-dependent inflammation in the development of SSBP.
RECENT FINDINGS: We recently found that sodium enters dendritic cells via ENaC, a process regulated by serum/glucocorticoid-regulated kinase 1 and epoxyeicosatrienoic acid 14,15. Sodium entry activates NADPH oxidase, leading to the production of isolevuglandins (IsoLGs). IsoLGs adduct self-proteins to form neoantigens in dendritic cells that activate T cells and result in the release of cytokines promoting sodium retention, kidney damage, and endothelial dysfunction in SSBP. Additionally, we described a novel mechanistic pathway involving ENaC and IsoLG-dependent NLRP3 inflammasome activation. These findings hold promise for the development of novel diagnostic biomarkers and therapeutic options for SSBP.
SUMMARY: The exact mechanisms underlying SSBP remain elusive. Recent advances in understanding the extrarenal role of ENaC have opened a new perspective, and further research efforts should focus on understanding the link between ENaC, inflammation, and SSBP.
Cerebral blood flow (CBF) is carefully monitored in the Neurointensive Care Unit (NICU) to prevent secondary brain insults in patients who have suffered subarachnoid hemorrhage. Including absolute MRI measurements of CBF in the NICU monitoring protocol could add valuable information and potentially improve patient outcomes. This is particularly feasible at Linköping University Hospital, which uniquely has an MRI scanner located in the NICU, enabling longitudinal CBF measurements while eliminating medical transportation risks. Arterial spin labeling is a subtraction-based MRI technique that can measure CBF globally in the brain without the use of contrast agents, and thus is suitable for repeated measurements over short time periods. Therefore, this work aims to develop and implement a methodological workflow for the acquisition, analysis, absolute quantification, and visualization of longitudinal arterial spin labeling MRI measurements acquired in the clinical NICU setting. At this initial stage, the workflow was implemented and tested using acquired test-retest data and longitudinal data from two healthy participants. Subsequently, the workflow was tested in clinical practice on an intubated and ventilated patient monitored in the NICU after suffering a subarachnoid hemorrhage. To ensure accurate day-to-day comparisons between the repeated measurements, the selection of processing and analysis methods aimed to obtain CBF maps in absolute units of ml/min/100g. These CBF maps were quantified using both the FMRIB Software Library and an openly available flow territory atlas. The test-retest data showed small variations (4.4 ml/min/100g between sessions), and the longitudinal measurement resulted in low CBF variability over 12 days. Despite the greater complexity of clinical data, the quantification and chosen visualization tools proved helpful in interpreting the results. In conclusion, this workflow including repeated MRI measurements could help detect changes in CBF between different measurement days and complement other conventional monitoring techniques in the NICU.
1,133,373. Hair dressings. L'OREAL. 13 May, 1966 [13 May, 1965], No. 21391/66. Heading A5B. [Also in Divisions C3 and C4] Hair lacquers and wave-setting lotions comprise at least one coloured copolymer of at least one monomer containing a reactive halogen atom and at least one ethylenically unsaturated monomer free from a reactive halogen atom, to which at least one dye containing a tertiary amine group is attached by quaternisation of the tertiary amine group. The lacquers and lotions may also contain a colourless terpolymer of (i) vinyl acetate, (ii) N- vinyl pyrrolidone and (iii) N-alkyl chloracetamide or vinyl chloracetate or, as cosmetic adjuvant, a perfume or plasticizer. The lacquers may be in the form of an aerosol composition and the lotions in the form of an aqueous alcoholic solution.