anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Effects of different winter paddock management of Thoroughbred weanlings and yearlings in Hokkaido, Japan, which is extremely cold in winter, on physiological function, endocrine function and growth were investigated. They were divided into two groups; those kept outdoors for 22 hr in the paddock (22hr group) and those kept outdoors for 7 hr in daytime with walking exercise for 1 hr using the horse-walker (7hr+W group), and the changes in daily distance travelled, body temperature (BT), heart rate (HR), HR variability (HRV), endocrine function and growth parameters were compared between the two groups from November at the year of birth to January at 1 year of age. The 7hr+W group could travel almost the same distance as the 22hr group by using the horse-walker. The 22hr group had a lower rate of increase in body weight than the 7hr+W group in January. In addition, lower in BT and HR were observed, and HRV analysis showed an increase in high frequency power spectral density, indicating that parasympathetic nervous activity was dominant. And also, changes in circulating cortisol and thyroxine were not observed despite cold environment. On the other hand, the 7hr+W group had higher prolactin and insulin like growth factor than the 22hr group in January, and cortisol and thyroxine were also increased. Physiological and endocrinological findings from the present study indicate that the management of the 7hr+W group is effective in promoting growth and maintaining metabolism during the winter season.
Effective behavioral insomnia treatments are typically delivered over an 8-week period. This format may not be easily exportable to primary and community care settings where military returnees and veterans seek help. The goal here is to test the effects of a 4-week behavioral treatment that targets chronic insomnia (lasting \>1 month) in service members returning from Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF), and who present with the typical psychiatric comorbidities associated of combat-related anxiety and mood disorders and stress reactions.
Caucasian male participants were administered a single SC injection of a unit dose strength of 150 mg per milliliter (mL) of GSK2831781, diluted in 0.9% w/v saline. Participants also received 2 dummy injections of 0.9% w/v saline placebo SC to maintain the blinding.
An estimated 12,500 Canadians are diagnosed with bladder cancer each year. Diagnosis and treatment involve transurethral (through the urethra) resection of tumor or tissue called the TURBT procedure. This procedure yields excellent results and minimal morbidity and mortality but has a high recurrence rate, difficulties in the pathologic interpretation of the specimen (due to cautery effect), and procedure-related complications (excessive bleeding, bladder perforation, bowel injury, and inadvertent extensive injury to urethra) that may delay treatments such as chemotherapy which would further impact oncologic outcomes. With the advancement of technology, new methods of transurethral tumor removal have emerged, such as the use of laser energy. Using laser energy, the tumour is resected in one piece, whereas the TURBT approach requires breaking the tumor into pieces. This allows for better pathology analysis that can determine treatment pathways for the patient, as well as reduces the risk of complications. The standard lasers used have been the MOSES Holmium laser and the Thulium Fiber Laser (TFL).
The present invention relates to a method for preparing yang-strengthening, fatigue-allaying and calcium-supplementing soymilk with micron ginseng powder, micron antler powder, micron pearl powder and micron pine pollen. The micron ginseng powder, the micron antler powder, the micron pine pollen and the micron pearl powder through high-technology airflow superfine grinding processing are added into the different traditional soymilk, and raw material such as oligosaccharide powder, intestinal tract beneficial bacteria, etc. are added, combined and fermented into the yang-strengthening, fatigue-allaying and calcium-supplementing soymilk. The yang-strengthening, fatigue-allaying and calcium-supplementing soymilk has the obvious functions of strengthening yang and allaying fatigue and also has the effects of supplementing calcium, enhancing immunity, tranquilizing, improving eyesight, etc. Middle-aged people and old people can obtain more than two hundred nutrient substances such as abundant protein, vitamins, mineral substances, active ferment, etc., and simultaneously, the yang-strengthening, fatigue-allaying and calcium-supplementing soymilk also has the functions of beautifying faces, keeping youthfulness and strengthening bodies because the pine pollen which is extolled as an oriental youthfulness keeping treasure is added. Therefore, the present invention is a favorable method for preparing health food of the yang-strengthening, fatigue-allaying and calcium-supplementing soymilk for health care and longevity, and the yang-strengthening, fatigue-allaying and calcium-supplementing soymilk has Chinese characteristics and is especially designed for the middle-aged people and the old people who have yang deficiency and cold intolerance all over the world.
Methods and apparatus for monitoring and improving imaging system operation are provided. An example apparatus includes a first deployed deep learning network (DLN) which operates with an acquisition engine to generate an imaging device configuration. The example apparatus includes a second deployed DLN which operates with a reconstruction engine based on acquired image data. The example apparatus includes a first assessment engine with a third deployed DLN. The assessment engine receives output from at least one of the acquisition engine or the reconstruction engine to assess operation of the respective at least one of the acquisition engine or the reconstruction engine and to provide feedback to the respective at least one of the acquisition engine or the reconstruction engine. The first deployed DLN and the second deployed DLN are generated and deployed from first and second training DLNS, respectively.
A coenzyme Q 10 containing self emulsifying drug delivery system is provided to be inexpensively manufactured, to have a simple manufacturing process, to be manufactured easily without other special conditions and to be used as drug or health food. A coenzyme Q 10 containing self emulsifying drug delivery system includes a coenzyme Q 10 as active component, a surfactant and a co-surfactant. The surfactant is polyglycerine fatty acid ester. The co-surfactant is a polyoxyethylene sorbitan fatty acid ester. An HLB value of the surfactant is 6 to 20. The coenzyme Q 10 containing the self emulsifying drug delivery system composition is manufactured by mixing the coenzyme Q 10, the surfactant and the co-surfactant at 40°C to 70°C.
PURPOSE:To obtain the slowly drug-releasable calcium phosphate cement having excellent bioaffinity and less biostimulability by using a mixture composed of tertiary calcium phosphate and secondary calcium phosphate which are so mixed as to attain 1.40 to 1.498Ca/P molar ratio as the essential component of the powder agent of the calcium phosphate cement. CONSTITUTION:The mixture composed of the tertiary calcium phosphate and secondary calcium phosphate which are so mixed as to attain 1.40 to 1.498Ca/P molar ratio is used as the essential component of the power agent of the calcium phosphate cement consisting of the power agent and a liquid agent and contg. the drug. The tertiary calcium phosphate consists of a mixture composed of alphatype tertiary calcium phosphate and beta type tertiary calcium phosphate. This slowly drug-releasable calcium phosphate cement consists of the calcium phosphate cement made of the specific compsn. having the high bioaffinity as its base material and, therefore, has excellent operability, has no possibility of impairing the drug action of the drug and is low in the biostimulability.
In clinical practice, functional limitations in patients with low back pain are subjectively assessed, potentially leading to misdiagnosis and prolonged pain. This paper proposes an objective deep learning (DL) markerless motion capture system that uses a red-green-blue-depth (RGB-D) camera to measure the kinematics of the spine during flexion-extension (FE) through: 1) the development and validation of a DL semantic segmentation algorithm that segments the back into four anatomical classes and 2) the development and validation of a framework that uses these segmentations to measure spine kinematics during FE. Twenty participants performed ten cycles of FE with drawn-on point markers while being recorded with an RGB-D camera. Five of these participants also performed an additional trial where they were recorded with an optical motion capture (OPT) system. The DL algorithm was trained to segment the back and pelvis into four anatomical classes: upper back, lower back, spine, and pelvis. A kinematic framework was then developed to refine these segmentations into upper spine, lower spine, and pelvis masks, which were used to measure spine kinematics after obtaining 3D global coordinates of the mask corners. The segmentation algorithm achieved high accuracy, and the root mean square error (RMSE) between ground truth and predicted lumbar kinematics was < 4°. When comparing markerless and OPT kinematics, RMSE values were < 6°. This work demonstrates the feasibility of using markerless motion capture to assess FE spine movement in clinical settings. Future work will expand the studied movement directions and test on different demographics.
PURPOSE OF REVIEW: The aim of this review was to provide an overview of the role of novel lipid biomarkers from the circulating lipidome in inflammatory processes and the impact that dietary patterns may have on the lipidome.
RECENT FINDINGS: Inflammation is a process that underlies many acute and chronic diseases, contributing to their development and severity. Finding novel molecules which serve as biomarkers and which are involved in inflammation is very useful, since they offer us both preventive or therapeutic targets and reveal mechanisms of action. Recently, several studies have found circulating lipid molecules that are implicated in inflammatory processes of different diseases, such as cardiovascular diseases, type 2 diabetes, COVID-19 or other respiratory infectious diseases. As such, ceramides, triacylglicerides or lysophosphatidylcholines have been associated with inflammation in a different manner depending on the stage of inflammation. The study of dietary patterns, especially healthy ones as the Mediterranean or the Nordic diets, has shown the impact that dietary habits may have on the lipidomic profile of individuals.
CONCLUSIONS: Healthy dietary patterns have been suggested to exert beneficial effects in the circulating lipid profile. Studying the circulating lipidome could help to find new biomarkers of underlying inflammation, especially in cases of chronic low-grade inflammatory diseases in which it is more difficult to detect.
PURPOSE:To provide a cosmetic containing a high-molecular silicone and a powdery polymethyl silsesquioxane, free from oily touch in application or stickiness of the skin after application and having a dry and comfortable feeling in use. CONSTITUTION:This cosmetic contains 0.1 to 15wt.% one or more kinds of high-molecular silicones represented by the formula [R1 is methyl or phenyl; R2 is methyl or OH; (n) is 3000 to 20000] and 0.1 to 15wt.% powdery polymethyl silsesquioxane as the active components. The compound of the formula exhibits a soft and rubbery state and its preferable example is methylphenyl polysiloxane. The powdery polymethyl silsesquioxane has a three-dimensional network structure of siloxane bonds and an intermediate structure between an inorganic material and an organic material in which one methyl group is bonded to a silicon atom. As this powdery polymethyl silsesquioxane, Tospearl 240 sold on the market is exemplified. As the form of cosmetics, a skin care cosmetic such as a lotion, a milky lotion or a cream, a make-up cosmetic such as a lip stick, an eye shadow or a foundation, a hair-care cosmetic, a detergent, etc., can be used.
The patients who applied to Marmara University Faculty of Dentistry Department of Prosthodontics with complaints of teeth clenching and grinding were clinically and radiologically examined. A questionarre is also applied to evaluate the sleep bruxism. 30 individuals diagnosed with sleep bruxism were included in this study. The individuals were informed about bruxism, its effects and the application of a stabilization splint and were divided into two groups randomly. Stabilization splint was applied to one group with digital and to other group with conventional impression and production method.

In the conventional treatment group, impressions were taken with alginate impression material, then the occlusal splint was fabricated with hard vinyl resin material in the dental laboratory. The splints were appllied o the upper jaw in accordance with the recomendations of Okeson. Canine guidence was provided in lateral movements. Autopolymerizing acrylic (Imıcryl, Turkey) was used for the adjustment of the splint intraorally. The individuals were asked to come for monthly recalls according to the routine treatment procedure and the pain values measured by visual analog scale (VAS). The occlusal surfaces of the stabilization splints were scanned before the usage of splint and after the three and six months usage. The wear amounts were calculated by Geomagic Control Program for evaluation. Patient satisfaction was evaluated with the questionarre at the beginning and final stage of the treatment.

In the CAD/CAM treatment group, intraoral digital impressions were taken with an intraoral camera (3Shape Trios (3Shape Dental Systems, Copenhagen, Denmark)) and the occlusal splints were fabricated with methacrylate resin material by digital three dimensional production. The splints were delivered to the individuals. Minimal occlusal adjustment was performed to obtain canine guidence. The individuals were asked to come for monthly recalls according to the routine treatment procedure and the pain values measured by visual analog scale (VAS). The occlusal surfaces of the stabilization splints were scanned before the usage of splint and after the three and six months usage. The wear amounts were calculated by Geomagic Control Program for evaluation. Patient satisfaction was evaluated with the questionarre at the beginning and final stage of the treatment.
<P>PROBLEM TO BE SOLVED: To provide a cosmetic which is highly transparent and glossy, has an excellent coloring property imparted by a dye, and prevents the dye from dyeing the skin.  <P>SOLUTION: This cosmetic is characterized by comprising at least an oiling agent, a dextrin fatty acid ester, a dye, and a modified silicone. The cosmetic can be produced by mixing at least the oiling agent, the dextrin fatty acid ester, and a modified silicone solution of the dye. The kind of the cosmetic includes anti-phlogistic sedative medicines such as medical sticks in addition to lipsticks, lip creams, lip glosses and fragrance sticks. The form of the cosmetic may be a solid or liquid form in addition to the cream form.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
According to the present invention, a liquid composition for vaporizing inhalation containing a new saponin is disclosed. A pharmaceutical extract containing a large amount of saponin extracted from red ginseng, a pharmaceutical agent, is mixed with eucalyptus oil and peppermint oil in a certain ratio, and vegetable glycerin and propylene glycol are added in a certain ratio as vaporization accelerators to form a vaporizable liquid substance. By vaporizing the vaporizable liquid substance with a vaporizing inhaler and allowing a user to inhale the same through the oral cavity and respiratory organ, a saponin component flows through the bloodstream and is delivered into the cells of human tissue. Accordingly, effects are provided by saponin such as removal and excretion of neutral fat and cholesterol, strengthening liver function, detoxification of heavy metals and various waste products, anti-inflammatory and anticancer activity, prevention of cancer by inhibiting the growth of cancer cells, activation of nerve cells, and subsequent improvement of memory and stabilization of the central nervous system. In addition, neuropsychiatric diseases such as dementia can be prevented through an anti-dementia effect of saponin. Moreover, respiratory diseases such as pneumonia, pulmonary tuberculosis, and asthma can be prevented and alleviated by antiviral and sedative effects of saponin, eucalyptus, and peppermint. The liquid composition of the present invention is manufactured by fermenting dried red ginseng with 50 percent alcohol to extract an extract containing saponin, and based on 30-40 wt% of a pharmaceutical extract obtained by re-concentrating the extract, adding 30 wt% of vegetable glycerin, 20 wt% of propylene glycol, 5-10 wt% of eucalyptus oil, and 5-10 wt% of peppermint oil and mixing evenly.
One of the participant's legs will be randomized to a unilateral resistance training arm for 10 weeks in duration. The leg chosen to be trained will undergo resistance exercise three days per week (Monday, Wednesday, and Friday) for the entirety of the study.
Since Coly-Mycin M Parenteral is eliminated mainly by renal excretion, it should be used with caution when the possibility of impaired renal function exists. The decline in renal function with advanced age should be considered.

When actual renal impairment is present, Coly-Mycin M Parenteral may be used, but the greatest caution should be exercised and the dosage should be reduced in proportion to the extent of the impairment. Administration of amounts of Coly-Mycin M Parenteral in excess of renal excretory capacity will lead to high serum levels and can result in further impairment of renal function, initiating a cycle which, if not recognized, can lead to acute renal insufficiency, renal shutdown, and further concentration of the antibiotic to toxic levels in the body. At this point, interference of nerve transmission at neuromuscular junctions may occur and result in muscle weakness and apnea (see OVERDOSAGE section).

Signs indicating the development of impaired renal function include: diminishing urine output, rising BUN and serum creatinine and decreased creatinine clearance. Therapy with Coly-Mycin M Parenteral should be discontinued immediately if signs of impaired renal function occur. However, if it is necessary to reinstate the drug, dosing should be adjusted accordingly after drug plasma levels have fallen (see DOSAGE AND ADMINISTRATION section).

Prescribing Coly-Mycin M in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.
Prolonged labor, defined as labor extending beyond 20 hours for nulliparas and 14 hours for multiparas, poses significant risks to both maternal and neonatal health. The inflammatory response plays a crucial role in the pathophysiology of prolonged labor, with neutrophils being key players in this process. Neutrophils, the most abundant leukocytes, exhibit diverse phenotypes and functions in response to prolonged labor, influencing both the onset and progression of labor through their inflammatory actions. Classical neutrophils (N1) are involved in acute inflammatory responses, aiding in tissue remodeling and labor onset, but their prolonged activation can lead to tissue damage. Regulatory neutrophils (N2), which produce anti-inflammatory cytokines, help resolve inflammation and facilitate labor progression. Low-density granulocytes and aged neutrophils, associated with chronic inflammation and impaired function respectively, contribute to labor complications. The balance among these neutrophil phenotypes is crucial for maintaining a controlled inflammatory response during labor. Therapeutic strategies targeting neutrophil recruitment, NETosis, and cytokine production hold promise for managing prolonged labor. Modulating chemokine pathways, regulating NET formation, and balancing cytokine profiles may reduce inflammation and improve labor outcomes. Further research into the mechanisms of neutrophil regulation and the development of targeted therapies is essential for mitigating the adverse effects of prolonged labor and enhancing maternal and neonatal health.
PURPOSE:An anti-inflammatory agent containing as an active component. CONSTITUTION:Ground krill (e.g. krill belonging to Euphausia genus such as superba, crystallorophias, frigida, etc., Thysanoessa genus such as macurura, etc.) is mixed with water, and left to stand. The supernatant liquid is separated, and added with a salt such as ammonium sulfate to effect the salting-out of the objective aqueous extract of krill (e.g. protease). Dose: preferably 10-500mg daily in terms of protease by oral administration. The protease originated from krill exhibits especially excellent anti-inflammatory action by oral administration, and is an extremely excellent anti-inflammatory enzymatic agent having low toxicity and free of side effect. Krill is distributed in the ocean all over the world, and is abundant especially in the antarctic district. The resource amounts to several hundred millions - two billion tons, and accordingly, krill can be supplied stably.
In a study of five healthy adults administered a single 500 mg dose of nafcillin by intravenous injection over seven minutes, the mean plasma concentration of the drug was approximately 30 mcg/mL at 5 minutes after injection. The mean area under the plasma concentration-versus-time curve (AUC) for nafcillin in this study was 18.06 mcg·h/mL. 

The serum half-life of nafcillin administered by the intravenous route ranged from 33 to 61 minutes as measured in three separate studies. 

In contrast to the other penicillinase-resistant penicillins, only about 30% of nafcillin is excreted as unchanged drug in the urine of normal volunteers, and most within the first six hours. Nafcillin is primarily eliminated by nonrenal routes, namely hepatic inactivation and excretion in the bile. 

Nafcillin binds to serum proteins, mainly albumin. The degree of protein binding reported for nafcillin is 89.9 ± 1.5%. Reported values vary with the method of study and the investigator. 

The concurrent administration of probenecid with nafcillin increases and prolongs plasma concentrations of nafcillin. Probenecid significantly reduces the total body clearance of nafcillin with renal clearance being decreased to a greater extent than nonrenal clearance. 

The penicillinase-resistant penicillins are widely distributed in various body fluids, including bile, pleural, amniotic and synovial fluids. With normal doses insignificant concentrations are found in the aqueous humor of the eye. High nafcillin CSF levels have been obtained in the presence of inflamed meninges. 

Renal failure does not appreciably affect the serum half-life of nafcillin; therefore, no modification of the usual nafcillin dosage is necessary in renal failure with or without hemodialysis. Hemodialysis does not accelerate the rate of clearance of nafcillin from the blood. 

A study which assessed the effects of cirrhosis and extrahepatic biliary obstruction in man demonstrated that the plasma clearance of nafcillin was significantly decreased in patients with hepatic dysfunction. In these patients with cirrhosis and extrahepatic obstruction, nafcillin excretion in the urine was significantly increased from about 30 to 50% of the administered dose, suggesting that renal disease superimposed on hepatic disease could further decrease nafcillin clearance.