anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The project starts facing the problem that families with children with severe health problems are exposed to strong emotional, social, economic and temporal burdens. This results in further health, social and economic risks, which often lead to poor living and care situations for the families concerned. This is attributed, among other things, to legal regulations that do not do justice to the respective individual life situations and the lack of competent advice and contact points. The overarching objective of the NEST project is the evaluation of an innovative support service that addresses the problem. The network support by so-called Family Health Partners \[Familien-Gesundheits-Partner; FGP\] aims to provide needs-based, individual care for all members in families with children in need of care, i.e. the best possible physical, psychological and participation-oriented care for children in need of care, thus relieving the relatives who spend much time for care and assistance of their child/children. The intervention to be evaluated here with regard to its effectiveness and to be analyzed with regard to its impact factors (processes and structures) was summarized in the term of FGP. This personalized function, which is anchored in the network, aims to provide "holistic" support for families with children in need of care. This means that the needs of the families are determined individually and initially independent of sectoral or service provider specific offers (structured assessment). The needs of families not only relate to medical, nursing or therapeutic care, but also to assistance regarding social law, economic and bureaucratic advice as well as social, psychosocial and emotional needs and social participation. Based on the identified need for support, affected families are individually accompanied by FGP over a certain period of time (in the project context: a maximum of 18 months). The medium-term goal of FGP support is to strengthen or maintain the family as a self-help system, i.e. self-efficient, independently acting primary resource for the care and support of their children (preventive).
PURPOSE:To provide the subject medicine containing a specified compound called CM-084 as the active component, exhibiting a strong affinity and selectivity to an MI-type receptor and capable of improving cholinergic neuropathy. CONSTITUTION:A medicine containing CM-084, i.e., a compound represented by the formula as the active component and capable of improving cholinergic neuropathy. As diseases accompanying cholinergic neuropathy, e.g. Altzheimer's disease, Altzheimer's senile dementia, Huntington's chorea, tardive dyskinesia, mania, etc., are exemplified. In addition, this medicine is effective for improving, e.g. dementia or derangement caused by cerebral angiopathy such as cerebral ischemia, cerebral infarction or cerebral hemorrhage, memory disorder caused by aging or dementia accompanying Parkinson disease.
Spinal anesthesia (SA) is currently the most preferred method of anesthesia in elective cesarean deliveries. However, SA causes maternal hypotension by decreasing systemic vascular resistance over sympathetic blockade. Maternal hypotension can lead to serious adverse events both in mother and in fetus: fetal hypoxia and acidosis occur due to decreased uterine blood flow, whereas the mother may experience vertigo, nausea, vomiting, alteration in consciousness, cardiovascular collapse and arrest. Today, various strategies have been suggested for the prevention of maternal hypotension. Of these strategies, the most critical ones are fluid load before spinal anesthesia (preloading) or rapid fluid load just after spinal anesthesia (coloading) and the use of vasopressor agent. The fluids used for this purpose include crystalloids and colloids. Comparative studies performed with colloid preloading, colloid coloading and crystalloid coloading indicated that the incidence of hypotension decreased similarly with no significant difference determined between the methods of fluid loading. Researchers defended necessity of using vasopressor agent together with fluid loading methods. In daily routine; however, the investigators observe that the incidence of hypotension is lower in the patients that undergo colloid preloading as compared to the patients that undergo colloid coloading or crystalloid coloading. The investigators therefore aimed to compare the methods colloid preloading and colloid coloading in terms of the incidence of maternal hypotension and impacts on neonatal outcomes. In the present study, the investigators aimed to use 6% HES 130/0.4 (Voluven ®), which is the newer generation colloid solution. The other aim while planning the present study is to identify the method of the lowest adverse event for mother and infant and the simplest approach for the clinician.
Control group participants will be recruited from the cancer patients in need of palliative care at Tata Medical Center (TMC), Kolkata, India. Participants will be recruited and consented by TMC researchers. There will be random allocation to the "control" or "Pal-Care" group. The control group (n=45) will receive "usual care" palliative services in which the patient or caregiver (by proxy) must visit the Tata Medical Center (TMC) cancer center for care. TMC services include consultation with a multi-disciplinary team (oncologist, nurse, psychologist), a 21-day morphine supply at reduced cost (as morphine is regulated in use),basic training on medication usage, catheter and wound care, other topics as relevant,and psychological counseling. Patients (or their proxy) must return to the cancer center as needed for follow up care and they are provided a 24/7 hotline to call in case of emergency.
Patients receiving haploidentical related donor transplant, diagnosis of myelofibrosis, \> 60 years old, or patients with comorbidity scores \> 3 will go in Group 3 or 4. If patients with comorbidity score \> 3, then the principal investigator is the final arbiter of eligibility for comorbidity score \> 3. Busulfan is administered at the dose calculated to achieve a total (including first two doses delivered on day -20 and day -13) system exposure of 20,000 +/- 12% uMol-min based on the pharmacokinetic studies.
Persistent hypoparathyroidism is an underestimate but major complication of total thyroidectomy. In this retrospective, observational, multicentre study, the investigators evaluated the quality of life using the SF-36 survey in comparison with a control population of patients thyroidectomized but free from this complication. Patients in six centers in France (Angers, Le Mans, Limoges, Nancy, Nantes, la Pitié-Salpétrière) and in the association "Hypoparathyroïdisme France" were contacted by mail. The primary endpoint was the mental health. The physic and global quality of life scores were assessed as secondary endpoints. Medical and VHI surveys were also send to the patients. The voice quality, the cardiovascular risk, the kidney function and the incidence of urinary lithiasis were also evaluated.
Veterinary anthelmintic compositions comprise a compound of general formula <FORM:0993528/A5-A6/1> wherein R represents a C1-4 alkyl radical, R1 represents a hydrogen atom or a C1-4 alkyl radical and Y represents a C1-5 alkyl radical dissolved in a mixture consisting essentially of a paraffin oil (phosphoramidate detoxicant component) and a phosphoramidate-solvent component selected from:-(i) one or more terpenes, (ii) one or more edible unsaturated aliphatic acids, (iii) one or more terpenes and one or more edible unsaturated aliphatic acids; any of these optionally also comprising either or both of one or more rosin acids and one or more water-insoluble esters of a long chain fatty acid with a polyhydric alcohol. Optionally, there may also be present one or more known liver fluke eradicating agents, e.g. CCl4, C2Cl6, C2Cl4F2.  Specified paraffin oils are medicinal grade paraffin oil and the material known as "Corvus" oil.  Specified terpenes are cineol, pinene, phellandrene, dipentene, terpinolene, cymene, a -terpineol, eucalyptus oil, eucalyptus gum solvent, eucalyptus terpene aldehyde fraction, wood turpentine and pine oil.  Specified unsaturated aliphatic acids are oleic, linoleic, ricinoleic and linolenic acids.  Rosin acids mentioned are those isolated from wood rosin, e.g. abietic, sapinic, pimaric, dihydroabietic and dehydroabietic acids and specified water-insoluble esters are glycerylmonooleate, -monoricinoleate and -dioleate and sorbitan monooleate.  Tall oil is also referred to as a component of the solvent component.  The compositions are preferably used as a drench or may be administered in capsules or feed-mixes or applied esternally.
FIELD: prophylactic medicine. SUBSTANCE: packing material contains natural filler of plant origin, such as buckwheat grain shelling wastes possessing bioenergomodulating properties. Natural filler is made in the form of separate unconnected members and single petals, dual petals and triple petals used in the following ratio, % by weight: single petals 10-90; dual petals 5-70; triple petals - the balance. Article has casing filled with natural filler of plant origin. EFFECT: wider range of packing materials, increased comfort, convenient usage and simplified manufacture process. 4 cl, 1 dwg
Teens in the experimental group will meet with a research counselor for five to nine individual, 50-minute weekly sessions. They will learn ways to deal with stress and feel better. The study counselor will also talk to the teen's doctor from time to time to help plan for the best possible care.
Cardiovascular disease (CVD) is a leading cause of death worldwide, and several studies have attempted to identify its risk factors. This study aimed to investigate the association between sleep duration and sleep quality, and the 7-year incidence of CVD among middle-aged and older Chinese individuals. A total of 6682 participants aged 45-90 years from the China Health and Retirement Longitudinal Study database were included in this study. The authors estimated sleep duration and quality based on self-reported data of night sleep hours and disturbance symptoms, and examined the associations between them and the composite outcome of CVD using logistic regression models. A total of 1692 participants (25.32%) reported new CVD events during follow-up. Short sleep duration (< 6 h/night) was significantly associated with a higher risk of CVD in all three models (p < .05). However, this was not observed for long sleep duration (> 8 h/night). Additionally, participants with mild sleep disturbance in all three models, and severe sleep disturbance in Models 2 and 3 had a significantly higher risk of CVD (p < .05). After stratification by age and daytime napping, we still found a significant association between short sleep duration and CVD in individuals aged 45-59 years, and between sleep disturbance and CVD in non-nappers (p < .05). However, these associations were not significant in individuals aged ≥60 years or in nappers (p > .05). In conclusion, short sleep duration and sleep disturbance are both associated with an increased risk of CVD in middle-aged and older Chinese individuals.
Prior to initiation, train patients and/or caregivers on proper preparation and administration of WAINUA [see Instructions for Use].

Remove the single-dose autoinjector from the refrigerator 30 minutes prior to the injection and allow to warm to room temperature. Do not use other warming methods.

Inspect WAINUA visually for particulate matter and discoloration prior to administration. The solution should appear colorless to yellow. Do not use if cloudiness, particulate matter, or discoloration is observed prior to administration. 

Administer WAINUA as a subcutaneous injection into the abdomen or upper thigh region. The back of the upper arm can also be used as an injection site if a healthcare provider or caregiver administers the injection.
Based on positive results in heavily pre-treated MBC patients, eribulin is being studied as first-line or second-line chemotherapy treatment. This is a non-randomized, open label study with participants enrolled in one of two cohorts: Cohort 1. Hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative (HR+/HER2-) or Cohort 2: Triple negative breast cancer (TNBC) meaning HR-negative/HER2-negative (HR-/HER2-). HR- means progesterone receptor-negative (PR-) and estrogen receptor-negative (ER-). Beyond efficacy as measured primarily by response to treatment, investigators will evaluate safety, tolerability and quality of life. In particular, it is hypothesized that eribulin may have lower rates of neuropathy, a common side effect of many of the major chemotherapeutics with activity in MBC. The investigators will study the effect eribulin has on the nerves through regular questionnaires that ask about any nerve-related symptoms. The investigators also plan to send blood samples to explore if gene markers may indicate increased sensitivity to the nerve effects of eribulin.
We evaluated the participation of the endocannabinoid system in the paraventricular nucleus of the hypothalamus (PVN) on the cardiovascular, autonomic, and plasma vasopressin (AVP) responses evoked by hemorrhagic shock in rats. For this, the PVN was bilaterally treated with either vehicle, the selective cannabinoid receptor type 1 antagonist AM251, the selective fatty acid amide hydrolase amide enzyme inhibitor URB597, the selective monoacylglycerol-lipase enzyme inhibitor JZL184, or the selective transient receptor potential vanilloid type 1 antagonist capsazepine. We evaluated changes on arterial pressure, heart rate, tail skin temperature (ST), and plasma AVP responses induced by bleeding, which started 10 min after PVN treatment. We observed that bilateral microinjection of AM251 into the PVN reduced the hypotension during the hemorrhage and prevented the return of blood pressure to baseline values in the posthemorrhagic period. Inhibition of local 2-arachidonoylglycerol metabolism by PVN treatment with JZL184 induced similar effects in relation to those observed in AM251-treated animals. Inhibition of local anandamide metabolism via PVN treatment with URB597 decreased the depressor effect and ST drop induced by the hemorrhagic stimulus. Bilateral microinjection of capsazepine mitigated the fall in blood pressure and ST. None of the PVN treatments altered the increased plasma concentration of AVP and tachycardia induced by hemorrhage. Taken together, present results suggest that endocannabinoid neurotransmission within the PVN plays a prominent role in cardiovascular and autonomic, but not neuroendocrine, responses evoked by hemorrhage.
A sustained-release preparation of a polypeptide drug for treating diabetes and a production method thereof relate to the technical field of diabetes prevention medicines. The sustained-release preparation provided by the invention is composed of phosphatide, PLGA, sesame oil, glycerin, exenatide and ethanol. According to the invention, the drug is uniformly wrapped in a biodegradation material. Due to hydrophobicity and viscosity of a packing material, the drug will not be rapidly released after subcutaneous injection, so as to greatly reduce stimulation of an injected position, slowly release the drug and obviously decrease toxic and side effect. Injection can be carried out once a week even once a month by controlling selection and proportion of the material. Above all, the production technology is simpler than traditional microsphere and liposome technologies. By the adoption of the production method, product quality is not only guaranteed, but cost is also remarkably reduced. As there exist no solid particles, 26/27G syringe needles can be adopted and are easily accepted by patients.
The system comprises one or more transportable bioreactors configured with the ability to conduct aerobic fermentation of fruit biomass. This system integrates three functionalities: transportation regulations, fermentation requirements and food safety/quality control requirements. The transportation design features of the system render the bioreactors transportable to a fruit processing facility, wherein they can be filled with fruit biomass. The transportable bioreactor and processes take into account the requirements of the bioreactor functionalities of the system, given the particular deployment specifications of the system tailored for a certain environment and fruit biomass. Moreover, the design of this system conforms to the minimal requirements for the food safety and quality regulations of the jurisdictions in which the ultimate products will be directly and/or indirectly sold (e.g., as a foodstuff, health supplement, and/or a food ingredient). The integration of these three types of functionalities (transport, bioreactor and sanitation) gives rise to a practical solution for addressing the various problems of wasted foodstuffs such as fruit biomass.
The plant hormone ethylene plays a critical role in fruit defense against Botrytis cinerea attack, but the underlying mechanisms remain poorly understood. Here, we showed that ethylene response factor SlERF.C1 acts as a key regulator to trigger the ethylene-mediated defense against B. cinerea in tomato fruits without compromising ripening. Knockout of SlERF.C1 increased fruit susceptibility to B. cinerea with no effect on ripening process, while overexpression enhanced resistance. RNA-Seq, transactivation assays, EMSA and ChIP-qPCR results indicated that SlERF.C1 activated the transcription of PR genes by binding to their promoters. Moreover, SlERF.C1 interacted with the mitogen-activated protein kinase SlMPK8 which allowed SlMPK8 to phosphorylate SlERF.C1 at the Ser174 residue and increases its transcriptional activity. Knocking out of SlMPK8 increased fruit susceptibility to B. cinerea, whereas overexpression enhanced resistance without affecting ripening. Furthermore, genetic crosses between SlMPK8-KO and SlERF.C1-OE lines reduced the resistance to B. cinerea attack in SlERF.C1-OE fruits. In addition, B. cinerea infection induced ethylene production which in turn triggered SlMPK8 transcription and enhanced the phosphorylation of SlERF.C1. Overall, our findings reveal the regulatory mechanism of the 'Ethylene-MPK8-ERF.C1-PR' module in resistance against B. cinerea and provide new insight into the manipulation of gray mold disease in fruits.
Tetrapectic acid is prepared by saponification of pectic acid under such mild conditions that hydrolysis leading to the formation of tetragalacturonic acids does not occur.ALSO:Inorganic heavy metal salts of therapeutic value which are normally insoluble in water are combined with pectic acid (as defined below) to give water soluble compounds.  An aqueous solution of pectic acid may be reacted with a metal salt of a weak acid or with a metal salt of a strong acid with neutralization by soda, and the metallic pectinate be precipitated with alcohol; or an alkali metal pectinate may be reacted with a metal salt and the pectinate be precipitated.  In either case, to an aqueous solution or suspension of the pectinate is added a salt, acid, or base which normally would precipitate the heavy metal, and from the resulting solution, the new compounds, referred to as "acid-metallic pectinates" are precipitated by alcohol as a water-soluble powder.  Instead of first isolating the metallic pectinate, the pectic acid, metal salt, and reagent adapted normally to precipitate the heavy metal may be reacted in a single stage.  By neutralizing the "acid-metallic pectinates" with alkalies or alkaline-earths, double salts may be obtained, and in this connection sodium silver pectinate and sodium mercury pectinate are referred to; alternatively the "acid alkali or alkaline-earth salts" may be combined with a heavy metal salt. Pectic acid is defined to include pectins, bassaronic acid, polyuronic acids such as tetragalacturonic 2-acid or di- or tetrauronic acids, and tetrapectic acid. Tetrapectic acid is prepared by saponification of pectic acid under such mild conditions that hydrolysis leading to the formation of tetragalacturonic acids does not occur.ALSO:Inorganic heavy metal salts of therapeutic value which are normally insoluble in water are combined with pectic acid (as defined below) to give water soluble compounds.  An aqueous solution of pectic acid may be reacted with a metal salt of a weak acid or with a metal salt of a strong acid with neutralization by soda, and the metallic pectinate be precipitated by alcohol; or an alkali metal pectinate may be reacted with a metal salt and the pectinate be precipitated.  In either case, to an aqueous solution or suspension of the pectinate is added a salt, acid, or base which normally would precipitate the heavy metal, and from the resulting solution, the new compounds, referred to as "acid-metallic pectinates," are precipitated by alcohol as a water-soluble powder.  Instead of first isolating the metallic pectinate, the pectic acid, metal salt, and reagent adapted normally to precipitate the heavy metal may be reacted in a single stage.  By neutralizing the "acid-metallic pectinates" with alkalies or alkaline-earths, double salts may be obtained, and in this connection, sodium silver pectinate and sodium mercury pectinate are referred to; alternatively, the "acid-alkali or alkaline-earth salts" may be combined with a heavy metal salt. Pectic acid is defined to include pectins, bassaronic acid, polyuronic acids such as tetragalacturonic 2-acid or tetra-uronic acids, and tetrapectic acid.
In our protocol we will test the hypothesis that closed-loop fluid administration can maintain higher cardiac stroke volume (shown to improve patient outcomes after surgery) than anesthesiologist management. We have shown this to be the case in multiple simulation studies and in-vivo animal studies, but not yet experimentally in a clinical setting. Investigators will recruit their patients from the surgical record that that require cardiac output monitoring undergoing surgery and require mechanical ventilation and consent to participate in the study will be included in the study. They will receive standard patient care in that in no way will their anesthetic or surgical procedure will be altered as part of the study, with the exception of fluid administration. Fluids are usually given to a patient based on the physician's discretion. As part of the study patients will receive fluid management via a closed loop (automated) system that will use an infusion pump (Q-Core) and a controller (a computer run index and algorithm developed by Sironis) to make frequent, regular and accurate adjustments to the amount of fluid the patient receives using feedback from standard operating room monitors at UCI). Data from this study will be retrospectively compared to subjects case matched to evaluate differences in cardiac output, total fluid given, and patient outcomes.
PURPOSE:To prepare the titled first agent capable of giving excellent wave to the hair without damaging the hair and scalp, by compounding a reducing agent such as thioglycolic acid, cysteine, etc. with a quaternary trimethyl ammonium- derivative of a polypeptide at a specific ratio. CONSTITUTION:The objective agent contains (A) 2-20wt% one or more reducing agents selected from thioglycolic acid, a thioglycolic acid salt, cysteine, a sulfite and a bisulfite and (B) 0.2-20wt%, especially 2-10wt% quaternary trimethyl ammonium-derivative of polypeptide of formula (R is amino acid side-chain constituting a polypeptide derived from animal protein; n is 3-20). The compound of formula is adsorbed to the hair and is left on the hair without being washed off by the rinsing process before the treatment with the second liquid. The excessive oxidization with the second liquid and the additive side effect of the first and the second agents can be suppressed to effect the remarkable suppression of the damage of the hair. The defects of the conventional first liquid are eliminated in the agent of the present invention.