anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The inflammation of chronic wounds plays a key hindering role in the wound healing process. Slowing down the inflammatory response is significant for the repair of chronic wounds. Studies have revealed that succinate can inactivate gastrin D (GSDMD) and prevent cell pyroptosis. Chitosan has anti-inflammatory properties and is commonly used as wound healing material. Therefore, we used succinic anhydride to modify chitosan and found that N-succinylated chitosan (NSC) was more effective in inhibiting inflammation. The results showed that the stimulation of TNF-α and high glucose induces overexpression of capase-1 and TNF-α in human umbilical vein endothelial cells (HUVEC), and down-expression of CD31. However, the expression of capase-1 and TNF-α decreased, while the expression of CD31, VEGF and IL-10 was up-regulated significantly in dysfunctional HUVEC cells after treated by NSC. Moreover, NSC can speed wound healing, histological examination results showed that wounds treated with NSC exhibited faster epithelial tissue regeneration and thicker collagen deposition. Overall, this study results suggested that NSC has the function of restoring the physiological functions of dysfunctional HUVEC cells induced by high glucose and TNF-α, and can accelerate wound healing, indicating that NSC has good potential to be applied in inflammatory chronic wounds such as diabetic foot.
Intestinal angioedema has been reported in patients treated with ACE inhibitors. These patients presented with abdominal pain (with or without nausea or vomiting); in some cases there was no prior history of facial angioedema and C-1 esterase levels were normal. The angioedema was diagnosed by procedures including abdominal CT scan or ultrasound, or at surgery, and symptoms resolved after stopping the ACE inhibitor. Intestinal angioedema should be included in the differential diagnosis of patients on ACE inhibitors presenting with abdominal pain.

In a large U.S. postmarketing study, angioedema (defined as reports of angio, face, larynx, tongue, or throat edema) was reported in 3/1523 (0.20%) of black patients and in 8/8680 (0.09%) of white patients. These rates were not different statistically.

### Anaphylactoid reactions during desensitization

Two patients undergoing desensitizing treatment with hymenoptera venom while receiving ACE inhibitors sustained life-threatening anaphylactoid reactions. In the same patients, these reactions were avoided when ACE inhibitors were temporarily withheld, but they reappeared upon inadvertent rechallenge.

### Anaphylactoid reactions during membrane exposure

Anaphylactoid reactions have been reported in patients dialyzed with high-flux membranes and treated concomitantly with an ACE inhibitor. Anaphylactoid reactions have also been reported in patients undergoing low-density lipoprotein apheresis with dextran sulfate absorption.
SS includes 2 visits. Subjects receive the workbook, paper copies of AP and food label exercise. Pre-testing will be done on V1 and Post testing on V2, eight weeks later. Subjects will be asked to read 1 chapter a week for the next 8 weeks. The pharmacist will provide a brief introduction of the workbook (5-10 minutes) and the AP. Only subject initiated questions will be answered. On V2, the pharmacist will answer subject initiated questions and ask about progress in the AP goal attainment and the program evaluation will be completed, as described in arm 1.Pharmacists track time spent at each visit to compare cost and outcomes.
Medication errors involving LAMICTAL have occurred. In particular, the names LAMICTAL or lamotrigine can be confused with the names of other commonly used medications. Medication errors may also occur between the different formulations of LAMICTAL. To reduce the potential of medication errors, write and say LAMICTAL clearly. Depictions of the LAMICTAL tablets, tablets for oral suspension, and orally disintegrating tablets can be found in the Medication Guide that accompanies the product to highlight the distinctive markings, colors, and shapes that serve to identify the different presentations of the drug and thus may help reduce the risk of medication errors. To avoid the medication error of using the wrong drug or formulation, patients should be strongly advised to visually inspect their tablets to verify that they are LAMICTAL, as well as the correct formulation of LAMICTAL, each time they fill their prescription.
In the treatment of auto-immune and inflammatory diseases, and for patients with organ transplants, immunosuppresive medicines such as corticosteroids and nonsteroidal anti-inflammatory drugs are used, however these have numerous adverse effects (hyperglycaemia, hypertension, muscle weakness, greater susceptibility to infections, osteoporosis, glaucoma, psychiatric disorders, stunted growth etc.) and outline the need to find new and improved immunosuppressive drugs which can be used, alone or in combination, in order to reduce the undesired effects. The inventors have discovered that the extract of the Chilean indigenous plant, Blechnum chilense, has anti-inflammatory and immunosuppressive effects and it is proposed that the bioactive molecules thereof with immunosuppressive activity will be useful for all those patients who need treatment with immunosuppressive drugs. Based on the analysis of the total extract of Blechnum chilense by means of LC-MS/MS and the presence of phenylpropane derivatives C 6 -C 3  and C 6 -C 3 -C 6  and undetermined core terpenes, it has been determined that it has a potential immunomodulator effect like polidin, butanediol, limonene, 5 Cl-phenyl trimethyl and an antioxidant effect like gamma-glutamyl methionine. In addition, the results indicate that Blechnum chilense does not have a cytotoxic effect on CD3+ T lymphocytes, of both human and murine origins, which was determined by means of the analysis of the total extract in a dosage range of 0.1ug/ml to 500 ug/ml, and that the methanolic and aqueous extracts in a dosage range of 10 ug/ml to 100 ug/ml demonstrate a clear inhibiting of lymphocyte proliferation, with CD3+ T lymphocytes of both human and murine origins not affecting the lymphocyte viability (see attached figures). In this way, the invention proposes a natural plant extract of Blechnum chilense containing bioactive secondary metabolites with immunosuppressive activity which inhibits the activation of T lymphocytes.
C-type lectins, distinguished by a C-type lectin binding domain (CTLD), are an evolutionarily conserved superfamily of glycoproteins that are implicated in a broad range of physiologic processes. The group XIV subfamily of CTLDs are comprised of CD93, CD248/endosialin, CLEC14a, and thrombomodulin/CD141, and have important roles in creating and maintaining blood vessels, organizing extracellular matrix, and balancing pro- and anti-coagulative processes. As such, dysregulation in the expression and downstream signaling pathways of these proteins often lead to clinically relevant pathology. Recently, group XIV CTLDs have been shown to play significant roles in cancer progression, namely tumor angiogenesis and metastatic dissemination. Interest in therapeutically targeting tumor vasculature is increasing and the search for novel angiogenic targets is ongoing. Group XIV CTLDs have emerged as key moderators of tumor angiogenesis and metastasis, thus offering substantial therapeutic promise for the clinic. Herein, we review our current knowledge of group XIV CTLDs, discuss each's role in malignancy and associated potential therapeutic avenues, briefly discuss group XIV CTLDs in the context of two other relevant lectin families, and offer future direction in further elucidating mechanisms by which these proteins function and facilitate tumor growth.
Clinical studies with erythromycin delayed-release capsules, USP did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of the decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

Elderly patients may be more susceptible to development of torsades de pointes arrhythmias than younger patients (see WARNINGS).

Elderly patients may experience increased effects of oral anticoagulant therapy while undergoing treatment with erythromycin (see PRECAUTIONS, Drug Interactions.)

erythromycin delayed-release capsules, USP do not contain sodium.
An ester of an amino-alcohol with titanic or zirconic acid, the amino-alcohol having the formula HORN(R1)(R11), where R is ethylene or an alkyl-substituted ethylene group, R1 is a b -hydroxyalkyl or b -aminoalkyl radical, and R11 is hydrogen, an alkyl radical of 1 to 3 carbon atoms or a b -amino-alkyl or b -hydroxy alkyl radical, is obtained by an ester exchange reaction between an alkyl titanate or zirconate and the amino alcohol, which may be triethanolamine, b -aminoethylethanolamine or diethanolamine.  The number of hydroxy groups per titanium or zirconium atom may vary from two to twelve, typical products being obtained by the reaction of one mol. of butyl titanate with one mol. of diethanolamine or two mols. of b -aminoethylethanolamine or four mols. of triethanolamine.  In examples, esters are produced from triethanolamine and tetrabutyl titanate or tetrabutyl zirconate, and from b -amine-ethylethanolamine and tetra-isopropyl titanate. In example (8), triethanolamine is reacted with tetrabutyl titanate at 25 DEG  C., and butyl alcohol is distilled off under reduced pressure to leave a triethanolamine solution containing 5 aminoalcoholic hydroxy groups for each titanium atom.ALSO:In a process of curling or crimping human hair, horse hair, wool, silk, zein, casein, soyabean, peanut or other protein fibres, or straightening already curly human hair, the fibres are treated with a liquid comprising an ester of titanic or zirconic acid with an amino alcohol of the formula HORN (R1) (R11), where R is ethylene or an alkyl-substituted ethylene group, R1 is a beta-hydroxyalkyl or betaaminoalkyl radical and R11 is hydrogen, an alkyl radical of 1 to 3 carbon atoms or a beta-aminoalkyl or beta-hydroxyalkyl radical. The ester may be obtained by an ester exchange reaction between an alkyl titanate or zirconate, such as tetra-butyl titanate or tetra-isopropyl titanate, and an amino alcohol such as triethanolamine, beta-aminoethyl-ethanolamine or diethanolamine. The ester may be a liquid suitable for application without dilution or may be applied in aqueous or alcoholic solution.  The treatment of human hair may be at room temperature or above and the solution may be activated by the inclusion of, or by pre- or after treating the hair with, acetic or formic acid, ammonium chloride, sodium hydroxide, sodium carbonate, ammonium carbonate, borax, ethylene diamine, hydrogen peroxide, sulphides or disulphides.  Human hair may be wound upon curlers, and the liquid may be applied by a sponge and removed with water after a period varying from 5 minutes to 3 hours while the hair is still wound or after unwinding the hair.  The hair may be after-treated with hydrogen peroxide and is subsequently dried.  In Example VIII wool cloth is impregnated with an aqueous solution of the ester obtained by reacting triethanolamine and tetrabutyl titanate at 25 DEG C., whereafter it is squeeze-dried, pleated and simultaneously dried on a roller heated to 140 DEG C., and finally washed with water and dried.
BACKGROUND: Hemorrhagic brain micro-arteriovenous malformations (micro-AVMs) are considered to constitute a relatively significant portion of pediatric AVMs, though they are often associated with a low bleeding rate, as seen in hereditary hemorrhagic telangiectasia, which frequently involves multiple micro-AVMs. We present a rare case of a 10-year-old girl with multiple hemorrhagic micro-AVMs. Intraoperative findings during the emergency operation for hematoma evacuation and post-operative superselective angiography highlighted the unique angioarchitecture of three micro-AVMs (two lesions in the superficial areas and one lesion in the deep-seated area) and the atypical bleeding source due to the complex congestive venous drainage system. One micro-AVM was successfully occluded by a transarterial emboliozation, and remaining two micro-AVMs underwent gamma knife irradiation as a salvage therapy.
CONCLUSION: Superselective angiography is crucial for detecting micro-AVMs, offering detailed insights into small, localized abnormal vascular drainage systems, and guiding therapeutic strategy. Additionally, micro-AVM-associated unique vascular hypersensitivity, such as vasospasm, requires careful consideration, as invasive procedures may significantly alter the visibility of the entire micro-AVM network.
Children likely to have a normal brain MRI will be asked to participate. After the brain MRI is obtained as part of routine clinical care, and a normal brain scan is confirmed, measurement of cerebral blood flow using velocity mapping in the jugular veins and the aorta will be performed. This will add approximately 10 minutes to the scan but no extra sedation medications will be administered to obtain this data.
Evolutionary dynamics of inversion and its impact on biochemical traits are a puzzling question. Here, we show abundance of inversions in three Curcuma species (turmeric, hidden ginger and Siam tulip). Genes within inversions display higher long terminal repeat content and lower expression level compared with genomic background, suggesting inversions in Curcuma experience relaxed genetic constraints. It is corroborated by depletion of selected SNPs and enrichment of deleterious mutations in inversions detected among 56 Siam tulip cultivars. Functional verification of tandem duplicated terpene synthase (TPS) genes reveals that genes within inversions become pseudogenes, while genes outside retain catalytic function. Our findings suggest that inversions act as a counteracting force against tandem duplication in balancing birth and death of TPS genes and modulating terpenoid contents in Curcuma. This study provides an empirical example that inversions are likely not adaptive but affect biochemical traits.
TKA patients will undergo total knee replacement as part of standard of care. The 3D printed mechanical balancer will be used at one timepoint during surgery while the patient is under anesthesia during their scheduled TKA surgery.
Type 2 diabetes is one of the most common diseases. In the year 2030 366 million patients are expected, which is a doubling in comparison to the year 2000. Besides a defective regulation of the glucose metabolism patients suffer from diseases of the kidney and the brain, which are named as diabetic nephropathies and diabetic neuropathies, respectively. Worldwide large efforts are undertaken to understand the causes of this disease. There is evidence, that a dysfunctional HNF4a plays an important role in the onset of diabetes. With the help of molecular biological and molecular genetic methods new HNF4a target genes (RSK4 and PAK5) were identified. These two genes encode for kinases. In a diabetic animal model RSK4 and PAK5 were selectively regulated. The identification of these genes and their fundamental importance for a therapy of type 1 and/or type 2 diabetes and/or nephropathies and/or neuropathies, including diabetic nephropathies and diabetic neuropathies is described. This invention has a high economic potential, since agents can now be identified for the control of genes, which regulation is disturbed by these diseases. Therefore new therapeutic concepts are possible for the treatment of type 1 and/or type 2 diabetes and/or nephropathies and/or neuropathies, including diabetic nephropathies and diabetic neuropathies.
The invention discloses an antibody coupling drug targeting EGFR, a preparation method and application thereof. The antibody drug conjugate targeting the EGFR is named as LR004-VC-MMAE and comprises an antibody, a cytotoxic drug and a linker, wherein the antibody drug conjugate has a structure shown in a formula I, wherein the mAb is an LR004 monoclonal antibody, and n is 2-8. The novel antibody coupling drug LR004-VC-MMAE can target EGFR antigen and has strong activity of killing tumor cells. Compared with LR004, the affinity, the endocytic activity and the targeting property of the antibody are not influenced, and the biological function of the antibody is well reserved. Compared with LR004, the tumor inhibition effect of the LR004-VC-MMAE antibody coupling drug is remarkably improved, and the situation of tumor disappearance appears. Compared with LR004, the LR004-VC-MMAE antibody conjugate drug total antibody has longer half-life, slower clearance rate, lower concentration of free MMAE in plasma, short half-life and fast clearance speed, and is beneficial to reducing toxicity.
Background: ventilator hyperinflation (VHI) has been shown to be effective in improving respiratory mechanics, secretion removal, and gas exchange in mechanically ventilated patients; however, the literature is scarce concerning its safety and adverse effects. Thus, the aim of this study is to compare the hemodynamic repercussions of VHI in volume-controlled mode.

Methods: in a randomized, controlled and crossover design, 24 mechanically ventilated patients will undergo 2 modes of ventilator hyperinflation (with and without an inspiratory pause of 2 seconds) and a control intervention. For the VHI interventions, the inspiratory flow will be set at 20 Lpm, and tidal volume will be increased until a peak pressure of 40cmH2O is achieved. During the control intervention, the patients will remain in volume-control ventilation with an inspiratory flow = 60Lpm and tidal volume = 6mL/IBW. The interval between interventions (washout) will be of 10 minutes or more, according to the time needed to recover the cardiac index to baseline values (maximum difference of 10%). Cardiac output, cardiac index, mean arterial pressure, pulmonary vascular resistance, systolic volume and other hemodynamic variables will be recorded during the interventions by using impedance cardiography.
FIELD: organic chemistry, medicine, hepatology. SUBSTANCE: invention relates to the novel chemical compound, mainly to 3-O-(2-deoxy-α-L- -rhamnopyranosyl)-11-oxo-20β-methoxycarbonyl-30-norolean-12-ene-3β-ol of the formula (I):   showing hepatoprotective activity. Proposed compound shows low toxicity and expressed hepatoprotective activity. Hepatoprotective effect of the compound (I) exceeds effect of glycyrrhizic acid and the known hepatoprotecting agent siliborum. EFFECT: new compound indicated above, enhanced hepatoprotective activity. 2 tbl
Immediately after induction of general anesthesia, the patient's head is turned slightly, and the table is tilted at 10 degrees, and the puncture point estimated by the anatomical landmarks are marked on the patient's skin. The investigators obtain a sonographic view at the estimated puncture point. It is recorded "success" when the internal jugular vein is visualized on the ultrasonography, and the estimated needle path passes the internal jugular vein. It is recorded "failure" if the internal jugular vein is not visualized on the ultrasonography, and the estimated needle path does not pass the internal jugular vein. After "failure" of the first attempt, the probe is either turned laterally or moved medially until the internal jugular vein is visualized on the ultrasonography, and the estimated needle path passes the internal jugular vein. The angle and distance is recorded. The location of the carotid artery is always marked on the ultrasonography for evaluation of complications.
Gemcitabine is given by vein over 30 minutes on days 1 \& 8 of each 21-day cycle. LY231514 is also given by vein over 10 minutes on day 8, following the Gemcitabine injection. Vitamin supplementation with oral folic acid and injectable B12 is initiated 7-10 days prior to the first dose of LY231514, and continuing throughout the patient's participation. Vitamin B12 is administered approximately every 9 weeks after the first injection. Appropriate antiemetic medication should be given to all patients. Dexamethasone 4mg PO twice daily is given for 3 days per cycle, beginning 1 day prior to LY231514 dosing. This is given to prevent or lessen the possibility of a rash.
AIMS: This study aimed to assess the practicality of using a stepwise pedigree-based approach to differentiate between familial and sporadic Dilated Cardiomyopathy (DCM), while also considering timing of the genetic analysis. The analysis includes an examination of the extent to which complete family investigations were conducted in real-world scenarios as well as the length of the investigation.
METHODS: The stepwise pedigree approach involved conducting a comprehensive family history spanning 3 to 4 generations, reviewing medical records of relatives, and conducting clinical screening using echocardiography and electrocardiogram on first-degree relatives. Familial DCM was diagnosed when at least 2 family members were found to have DCM, and genetic analysis was considered as an option. This study involved a manual review of all DCM investigations conducted at the Centre of Cardiovascular Genetics at Umeå University Hospital, where the stepwise pedigree approach has been employed since 2007.
RESULTS: The investigation process had a mean duration of 643 days (95% CI 560.5-724.9). Of the investigations preformed, 94 (68%) were complete, 12 (9%) were ongoing, and 33 (24%) were prematurely terminated and thus incomplete. At the conclusion of the investigations, 55 cases (43%) were classified as familial DCM, 50 (39%) as sporadic DCM, and 22 (18%) remained unassessed due to incomplete pedigrees. Among the familial cases, genetic verification was achieved in 40%.
CONCLUSION: The stepwise pedigree approach is time consuming, and the investigations are often incomplete which may suggest that a more direct approach to genetic analysis, may be warranted.
Impaired control of the G1/S checkpoint allows initiation of DNA replication under non-permissive conditions. Unscheduled S-phase entry is associated with DNA replication stress, demanding for other checkpoints or cellular pathways to maintain proliferation. Here, we uncovered a requirement for ADARp150 to sustain proliferation of G1/S-checkpoint-defective cells under growth-restricting conditions. Besides its well-established mRNA editing function in inversely oriented short interspersed nuclear elements (SINEs), we found ADARp150 to exert a critical function in mitosis. ADARp150 depletion resulted in tetraploidization, impeding cell proliferation in mitogen-deprived conditions. Mechanistically we show that ADAR1 depletion induced aberrant expression of Cyclin B3, which was causative for mitotic failure and whole-genome duplication. Finally, we find that also in vivo ADAR1-depletion-provoked tetraploidization hampers tumor outgrowth.