anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PCT No. PCT/JP95/00419 Sec. 371 Date Mar. 1, 1996 Sec. 102(e) Date Mar. 1, 1996 PCT Filed Mar. 14, 1995 PCT Pub. No. WO95/25287 PCT Pub. Date Sep. 21, 1995The present invention provides semi-spherical materials to be worn on the eyeball, such as contact lenses for visual acuity correction or medical treatment use, cornea protecting materials, controlled drug release contact lenses and the like, which comprise, as a main component, a glycosaminoglycan existing in the living body as an extracellular matrix component of connective tissues and satisfy various requirements such as dimentional stability, transparency, surface water wettability, tissue compatibility, oxygen permeability and the like. In other words, the material to be worn on the eyeball has a shape of semi-spherical surface compatible in shape with the mammalian eyeball and has biological and surface-physical compatibilities with ophthalmic tissues and comprises, as a main component, a substantially transparent photocured crosslinked-glycosaminoglycan obtained by allowing photoreactive groups covalently bonded to a glycosaminoglycan to crosslink mutually by photoirradiation.
One cycle consists of treatment with hu3F8 at a dose of 2.4mg/kg/dose for 3 days (day 1, 3, and 5) in the presence of subcutaneous (sc) GM-CSF (day -4 through 5). These 3 doses of hu3F8 and 10 days of GM-CSF constitute a treatment cycle. Cycles are repeated at \~2-4 week intervals between first days of hu3F8, through 5 cycles. A maximum of 5 cycles will be administered on protocol. If elevations of amylase and/or lipase (\>Grade 1) or clinical signs suggestive of pancreatitis (e.g. upper abdominal pain) occurs, naxitamab and GM-CSF doses should be held until improvement of toxicity to ≤Grade 1 if laboratory elevations and/or pancreatitis is possibly related to either naxitamab or GM-CSF.
Patients receive bortezomib IP and carboplatin IP on day 1. Treatment repeats every 21 days for 6 courses in the absence of disease progression or unacceptable toxicity.
PROBLEM TO BE SOLVED: To provide a medical data management system which secures a high operating rate in an institution provided with expensive equipment and enables an intermediate or small size institution which not has expensive equipment to give an answer to a patient with use of the state-of-the art medical data, while maintaining patients. SOLUTION: The medical data management system is comprised of a reservation data file, to which reservation data from plural first medical institutions which are not provided with prescribed medical equipment is inputted, an equipment operation data file, to which data from plural second medical institutions provided with the prescribed medical equipment is inputted, and a data file of videos or the like where results of examination performed by medical equipment of second medical institutions are stored. The usage conditions of medical equipment of second medical institutions are retrieved by the first medical institutions. The prescribed medical equipment is used in the second medical institutions, after retrieval. Data obtained from the medical equipment after retrieval is transmitted to the data file of videos or the like.  The first medical institutions retrieve this data file of videos or the like and output the result.
OBJECTIVE: Providing the human papillomavirus (HPV) vaccine is effective to eliminate the disparity in HPV-related cancers. It is unknown regarding inequality in the distribution of HPV vaccination in China since the vaccine was licensed and approved for use in 2016. This study aimed to examine socioeconomic inequalities in HPV-related knowledge and vaccination and identified factors associated with such inequalities.
METHODS: Self-administered questionnaires measuring HPV-related knowledge and vaccine uptake were completed by 1,306 women through online survey platform. HPV knowledge was assessed using a 12-item question stem that covered the hazards of HPV infection, HPV vaccine dosage, benefits, and protection. Cluster analysis by combining monthly household income, educational level, and employment status was used to identify socioeconomic status (SES) class. The concentration index (CI) was employed as a measure of socioeconomic inequalities in HPV-related knowledge and vaccination. Linear regression and logistic regression were established to decompose the contributions of associated factors to the observed inequalities.
RESULTS: The CI for HPV-related knowledge and vaccine uptake was 0.0442 and 0.1485, respectively, indicating the higher knowledge and vaccination rate were concentrated in groups with high SES. Education and household income made the largest contribution to these inequalities. Age, residency and cervical cancer screening were also important contributors of observed inequalities.
CONCLUSION: Socioeconomic inequalities in HPV-related knowledge and vaccination uptake are evident in China. Interventions to diffuse HPV-related information for disadvantaged groups are helpful to reduce these inequalities. Providing low or no-cost HPV vaccination and ensuring accessibility of vaccines in rural areas are also considered to be beneficial.
Gastric varies (GV) rarely rupture. However should it occur, the outcome would be worse than rupture of esophageal varies (EV). Rupture of GV is characteristic of a higher rebleeding rate, a requirement for a larger amount of blood transfusion and a higher mortality. Up to date, the treatment of GV bleeding (GVB) is still sub-optimal in contrast to the treatment of EV bleeding. The management of GV has been focused on treatment of acute GVB. Various specific methods are used to control GVB and prevent rebleeding; however they were far from ideal. It is because GV are usually larger vessels formed in deeper submucosa and connect to the spontaneous gastrorenal shunt which creates a fast blood flow. Therefore, voluminous blood in the larger diameter GV leads to exsanguine bleeding when ruptured. A variety of endoscopic methods, which include injection of sclerosants, tissue adhesive (cyanoacrylate), thrombin and ligation with rubber bands, detachable nylon loop and steel snares, are applied to control acute GV bleeding with variable successful rates (50\~100%) and rebleeding rates (20\~90%). The successful rate of endoscopic cyanoacrylate injection to arrest active GVB is more consistent around 90\~100% and rebleeding rate is around 30\~40%. The recent International Consensus Meeting endorsed that endoscopic cyanoacrylate injection is the first line treatment for acute GVB. The embolic complications, either septic \& aseptic, are not uncommon. Expertise is also required to reduce the embolic complications and instrumental injuries. Therefore, the efficacy of specific treatment for GVB is sub-optimal, consecutive innovation of new methods are required to improve the prognosis of GVB. Non-selective beta-blocker is effective to reduce rebleeding from esophageal varices. However, its effect on gastric variceal hemorrhage has never been proven.

This is an important issues prompted by current portal hypertension experts. We have much experience in the treatment of gastric variceal bleeding and published fruitful results in high ranking journal. Therefore, we design a randomized trial to compare the effect of endoscopic cyanoacrylate injection obliteration versus non-selective beta-blocker in the secondary prevention of acute gastric variceal bleeding.
Retrospective cohort study by chart review. We propose to review the charts of four thousand women obtaining abortion in British Columbia, BC. Data will be extracted from the charts of women who obtained abortions between January first 2002 and June 30, 2008 inclusive at two abortion clinics in Vancouver, British Columbia: BC Women's Hospital CARE program, and the Elizabeth Bagshaw Women's Clinic. Specifically we will record age, parity, date of LMP, presence of regular cycles, ultrasound estimation of gestational age, ultrasound measurements: crown rump length, bi-parietal diameter, gestational sac diameter if available, date of abortion, estimation of gestational age by examination of the products of conception, and fetal foot length if available. Further we will record associated factors such as contraception at time of conception, intravenous drug use, and regularity of menstrual cycle. We will calculate the gestational age at time of abortion by the LMP date, by the ultrasound date reported, ultrasound date based on the Hadlock protocol by the reported CRL and similarly BPD as well as calculating the gestational age based on the recorded fetal foot length.
BACKGROUND: Due to the burden of musculoskeletal diseases in the elderly and the multifactorial nature of such conditions, controlling the pain caused by these disorders requires multidisciplinary approach. This approach requires the participation of the elderly in applying effective prevention measures. This study aims to design a multidisciplinary educational intervention based on health belief model (HBM) for elderly residents of nursing homes.
METHODS: This is a parallel randomized clinical trial among elderly people aged 60 years and over living in a nursing home who suffer from musculoskeletal pain. Eligible participants will be divided into two groups including the intervention group who will receive a multidisciplinary intervention (vitamin D consumption, psycho-social stress management, and physiotherapy) and the control group who will receive usual care. Data collection instruments will include demographic data, the Depression, Anxiety, and Stress Scale (DASS), the visual analogue scale (VAS), and a self-designed questionnaire containing the HBM constructs. The interventions will be carried out by the educational team (general practitioner, psychologist, physiotherapist, and health education specialist). Interventions include changing the wrong beliefs of the elderly, taking 800 units of vitamin D daily, daily walking exercise by the elderly for at least 30 min and maintaining proper body posture during daily activities, muscle relaxation, relaxation techniques, regular exercise, examining their diet and eliminating stimulants (such as smoking and coffee), regular visits with friends and family, and deep breathing techniques. All questionnaires will be completed by the elderly before, after, 3, and 6 months after the intervention.
DISCUSSION: The present study will evaluate the effect of an educational intervention based on a multifaceted pain control approach for elderly people who reside in nursing homes in order to reduce musculoskeletal pain in the elderly living in nursing homes. One of the features of this study is its focus on improving the health of elderly residents in nursing homes. Given the increase in the elderly population worldwide, the findings from the current trial might benefit elderly populations.
TRIAL REGISTRATION: IRCT20220904055881N1 . Registered on 11 February 2023.
There is disclosed a system and method for processing multi-modal collaboration. In an embodiment communication received from multiple modes are converted into a common format. Using various conversion modules, the communication may be converted into a common electronic text format (e.g. ASCII text) that contains keywords. Once the communication is converted into a common format, the information contained in the communication may be analyzed and consolidated into related areas or topics. The consolidated information may then be searched for common references in order to augment the information context.
The invention relates to novel application for treating acne through heat clearing and dampness removing of Chinese herbal medicaments of angelica, sophora and fresh rehmannia. The invention relates to the novel application through the decoction of medical soup, tea and health-care beverage by 10 g of angelica, 15 g of sophora and 30 g of fresh rehmannia, 15 g of arctium, 20 g of mulberry bark, 15 g of loquat leaf, 30 g of oldenlandia, 15 g of dictamnus, 15 g of soil pachyma cocos Qin, 2 0g of leonurus, 15 g of white paeony root, 10 g of scutellaria, 10 g of liquorice root and other Chinese herbal medicaments or the preparation of tablets, pills, injection, pulvis, oral liquid, aerosol, medicinal oil, sponginum and capsules by the Chinese herbal medicaments. The application mainly treats the acne and has the functions of clearing heat, dampness removing, attempering thoroughfare and controlling vessels and the like. The application is suitable for dampness and heat of lung and stomach and external pathogenic toxin. Therefore, the application uses the mulberry bark the loquat leaf, the oldenlandia, the dictamnus, the soil pachyma cocos Qin, the sophora and the scutellaria to clear sthenopyra of two channels of lung and stomach and can detoxify and dry dampness; the angelica and the arctium directly reach two channels of the lung and stomach, can dispel wind and detoxify, remove abscess and penetrate diagnosis and remove obstruction; the fresh rehmannia nourishes Yin, cools blood and avoids injuring healthy qi; the liquorice root attempers a plurality of the medicaments; and the leonurus attempers thoroughfare and controlling vessels. The medicaments achieve the efficacies of clearing heat, dampness removing and attempering the thoroughfare and controlling vessels.
How to present an intelligent model based on known diagnostic knowledge to assist medical diagnosis and display the reasoning process is an interesting issue worth exploring. This study developed a novel intelligent model for visualized inference of medical diagnosis with a case of Traditional Chinese Medicine (TCM). Four classes of TCM's diagnosis composed of Yin deficiency, Liver Yin deficiency, Kidney Yin deficiency, and Liver-Kidney Yin deficiency were selected as research examples. According to the knowledge of diagnostic points in "Diagnostics of TCM", a total of 2000 samples for training and testing were randomly generated for the four classes of TCM's diagnosis. In addition, a total of 60 clinical samples were collected from hospital clinical cases. Training samples were sent to the pre-training language model of Chinese Bert for training to generate intelligent diagnostic module. Simultaneously, a mathematical algorithm was developed to generate inferential digraphs. In order to evaluate the performance of the model, the values of accuracy, F1 score, Mse, Loss and other indicators were calculated for model training and testing. And the confusion matrices and ROC curves were plotted to estimate the predictive ability of the model. The novel model was also compared with RF and XGBOOST. And some instances of inferential digraphs with the model were displayed and analyzed. It may be a new attempt to solve the problem of interpretable and inferential intelligent models in the field of artificial intelligence on medical diagnosis of TCM.
The utility model relates to a prostate relieving paste, which comprises a bottom membrane layer, a facial membrane layer and a mediated core arranged between the bottom membrane layer and the facial membrane layer. In addition, the utility model also contains an adhesive layer arranged on the bottom membrane layer. The bottom membrane layer is shaped by a circular arc with a radius R1 of 45mm to 55mm and a circle center on symmetrically central line, a circular arc with a radius R3 of 30mm to 40mm and a circle center on symmetrically central line which are in the same plane in addition to a circular arc with a radius R2 of 170mm to 190mm and a circle center on the same side of the symmetrically central line, which is engaged with the circular arcs of the R1 and the R3 and a circular arc with the radius R3 of 30mm to 40mm and a circle center on the same side of the symmetrically central line, which is also engaged with the circular arcs of the R1 and the R3. The distance between the circle center of the circular arc with the radius R1 and the circle center of the circular arc with the radius R3 is 30mm to 40mm. The medicated core is divided into at least two sections. Moreover, the utility model having the advantages of simple structure, convenient use and good using effect can be generalized in clinical use.
Translational control plays a crucial role in the regulation of apoptosis, with the EIF4 family serving as one of the mRNA translation factors that modulate the process of mRNA translation based on mRNA characteristics. To address this potential causal role of EIF4 family proteins and breast cancer, Mendelian randomization was employed. The study incorporated four sets of genetics instrumental variables, namely EIF4E, EIF4B, EIF4A, and EIF4EBP2. The outcome variables selected for analysis were the BCAC consortium, which included estrogen receptor positive (ER+) and estrogen receptor negative (ER-) samples. To assess the potential violations of the MR assumption, the primary MR analysis employed inverse variance weighted (IVW), and several sensitivity analyses were conducted. The findings of the two-sample MR analysis indicate that EIF4E has an adverse effect on breast cancer risk (p = 0.028). However, the evidence for the relationship between EIF4E and ER status of breast cancer suggests a weak association with ER+ breast cancer (p = 0.054), but not with ER- breast cancer (p > 0.05). The study findings indicate that EIF4A is not causally linked to the risk of ER+ breast cancer, but is significantly associated with an elevated risk of ER- breast cancer (p = 0.028). However, the evidence is inadequate to support the effects of EIF4B and EIF4EBP2 on breast cancer (p > 0.05). Our results suggest that EIF4 may be a potential factor in the occurrence and development of breast cancer, which may lead to a better understanding of its causes and prevention.
This study is aimed in comparison among two interventional techniques i.e neural mobilization and muscle energy technique patients with sciatica. This study will be a randomized controlled trial with double blinded protocol, patients will be randomly allocated in to the two groups. one is the neural mobilization technique group and other is the muscle energy technique group. both of the groups have the conventional physical therapy in addition to these two interventions. data will be collect from the patients.30 minutes session twice a week will be given to the patients in each group. assessment will be done by using visual analog scale, Goniometer, Modified Oswestry Disability Index. Data will be entered and analyzed by using SPSS.
The aim of this study is to evaluate the effects of chloral hydrate, hydroxyzine and melatonin, which are used as sedative agents before EEG recording in children, on sleep success, time to fall asleep, side effects and EEG background.It is a randomized controlled experimental study.The universe of the study consisted of all children who had EEG recordings in the Pediatric Neurology Outpatient Clinic of a tertiary hospital. Its sample is; It comprised 180 children aged 1-7 years who met the inclusion criteria, evaluated for epilepsy, suspected epilepsy, febrile convulsions, and other neurological diseases.G power program was used to determine the sample size of the study. For each group (chloral hydrate, hydroxyzine, melatonin and natural sleep) 45 individuals were included in the study by taking 95% power and 0.05 margin of error while making the calculation. Randomization was carried out in the study in order to provide an equal number of samples for each group (chloral hydrate, hydroxyzine, melatonin and natural sleep) and to avoid bias. "Block randomization method" was used in order to provide equal samples for all four groups in randomization.Data Collection tools of the research; Child's Information Form, Ramsay Sedation Score, Steward Recovery Score. Statistical analyzes of the study were performed with the SPSS 20.0 (IBM Incorp, Chicago, IL, USA) program. Descriptive measures were frequency (percentage ratio) for categorical variables, mean±SD and median for numerical variables; It was presented as Q1-Q3. Conformity of continuous numerical measurements to normal distribution was tested by Kolmogorov-Smirnov method, but it was found that it did not fit normal distribution (p \<0.05). Multivariate logistic regression model was established to determine the properties that are effective on sedative substances. A p value of \<0.05 was considered statistically significant in the entire study. In order to conduct the study, ethical approval from the Antalya Training and Research Hospital Clinical Research Ethics Committee, approval from the Turkish Medicines and Medical Devices Agency, institutional permission from the hospital where the study will be conducted, and written consent from the participants were obtained.
FIELD: diabetes treatment means. SUBSTANCE: invention, in particular, relates to preparing material containing beta-cells from new- born rabbit pancreas and to transplantation methods for treating mainly hormone-linked diabetes mellitus by transplanting beta-cells prepared by utilizing phenomenon of their migration. Isolated pancreatic gland is washed, cut into fragments and thus prepared material is used to sow on cultural mattresses to which also culture medium and mammal serum are added. Further, conditions are created under which more than 90% of beta- cells freely migrate from cultured pancreatic fragments toward bottom of cultural mattress. Treatment of diabetes consists in transplanting thus prepared material into various organs and tissues. EFFECT: simplified procedure, increased yield of non-damaged beta-cells, and increased treatment efficiency. 14 cl, 2 tbl
PURPOSE: A composition containing Coriandum sativum. L extract is provided to prevent cells from H_2O_2 stimulation, to suppress ROS, and to ensure antioxidation effect. CONSTITUTION: A cosmetic composition for improving anti-wrinkling contains Coriandum sativum. L extract as an active ingredient. The extract is prepared using water, low carbon number alcohol of C1-C2, or mixture solvent thereof. The low carbon number alcohol includes ethanol or methanol. A pharmaceutical composition and health food for improving anti-wrinkling contains the extract as an active ingredient.