anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention concerns to medicine and concerns a method of treatment of ulcero-necrotic stomatitis.          The purpose of the invention is reduction of terms of treatment. The essence of a method consists in rinsing a mouth before and after meal by broth from a green baikhovi leaf or the dried tea leaf, simultaneously with its reception inside.         After rinsing the affected sites are spread with a preparation containing water and oil extracts, received of green baikhovi tea or the dried or fresh tea leaf with addition of the crushed raw material in proportion extract: raw material 1,0:35-0,5 and ascorbic acid at the relation to raw material 0,5-1,0:10. The positive effect consists in reduction of terms of treatment from 10 days up to 5.           1 tab.
Triiodo-isophthalamic acid derivs. of formula (I): (where A is aminoacyl; X is an opt. branched 2-14C hydrocarbon chain opt. interrupted by 1 or more O- or S-atoms; and R1 and R2 are different and are OH or NR3R4, R3 and R4 being H or lower alkyl opt. substd. by OH, or NR3Rj is a heterocyclic residue opt. interrupted by a further hetero atom), and their physiologically tolerable salts with bases are new cpds. (I) are X-ray contrast agents useful in the form of their water-soluble salts as injection preparations for angiography, myelography and, esp. urography. The toxicity of (I) is low, their general, neural and local tolerances is good, and their effect on the circulation is slight. When used in angiography the incidence of subjective side-effects is low. Excretion via the kidneys is high and rapid, but excretion via the bile is minimal.
4-(6-oxo-2-(trifluoromethyl)-3,6-dihydrochromeno[7,8-d]imidazole-8-yl)benzonitrile, also known as CF3CN, for use in the treatment of diseases and conditions associated with movement disorder is provided. Preferably, the diseases or conditions are selected from the group: ataxia, cerebral palsy, cervical dystonia, chorea, dystonia, epilepsy, functional movement disorder, Huntington’s disease, multiple sclerosis, multiple system atrophy, myoclonus, Parkinson’s disease, Parkinsonism, progressive supranuclear palsy, restless leg syndrome, tardive dyskinesia, Tourette syndrome, tremor disorders such as essential tremor, and Wilson’s disease. Preferably the condition associated with movement disorder is additionally associated with cognitive impairment. Most preferably the disease or condition is Huntington’s disease, Parkinson’s disease, and essential tremor. The disease or condition may be a drug-induced movement disorder selected from: serotonin syndrome, acute dystonic reason, neuroleptic malignant syndrome, Parkinsonism, or tardive drug-induced movement disorder. CF3CN may be administered as a single dose or multiple daily doses wherein the dose comprises at least 0.001mg of CF3CN, particularly about 0.001mg to about 500mg.
All patients were premedicated 15 minutes before the surgical procedure with I.V. 0.06mg/kg of midazolam. In the operating room, patients were monitored for non invasive blood pressure (NIBP), oxygen saturation (Spo2) and pulse rate (PR).

Two cannulae were placed, one in a vein on the dorsum of the operative hand and the other on the non operative hand for i.v fluids. The operative arm was elevated for 2 min and was then exsanguinated with an elastic bandage. A pneumatic tourniquet was then placed around the upper arm, and the cuff was inflated to 100 mm Hg above systolic BP. Circulatory isolation of the arm was verified by inspection, absence of a radial pulse, and a loss of the pulse oximetry tracing in the ipsilateral index fingers. The solutions were prepared by an anesthesiology assistant not involved in any part of the study. The solutions were injected over 90 s by an anaesthesiologist. During surgery if patient reported pain during operation (VAS 4 or greater) inj. fentanyl 1 μg/kg was given and total amount used was recorded. Postoperatively patients were questioned for pain and if VAS \> 4, 75 mg intramuscular diclofenac was given.Total amount used was recorded.
Indomethacin Extended-release capsules USP 75 cannot be considered a simple analgesic and should not be used in conditions other than those recommended under . INDICATIONS AND USAGE

Indomethacin is a nonsteroidal, anti-inflammatory, indole derivative designated chemically as 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1 -indole-3-acetic acid. Indomethacin is practically insoluble in water and sparingly soluble in alcohol. It has a pKa of 4.5 and is stable in neutral or slightly acidic media and decomposes in strong alkali. The structural formula is: H

Each extended-release capsule, for oral administration contains 75 mg of indomethacin. In addition, each capsule contains the following inactive ingredients: corn starch, D&C Yellow# 10, gelatin, mannitol, povidone, sucrose, talc, and titanium dioxide.

This product meets USP Drug Release Test 2 Specifications.
PURPOSE:To obtain spherical anhydrous calcium secondary phosphate capable of polishing and cleaning teeth without damaging the surfaces of the teeth when used as a polishing agent for toothpaste by prescribing the average roundness of spherical anhydrous calcium secondary phosphate, the rate of liq. absorption, the angle of repose, the specific surface area and the average particle size. CONSTITUTION:A Ca compound such as CaO is reacted with a phosphoric acid compound such as phosphoric acid at >=50 deg.C in the presence of a condensation product of phosphoric acid such as tripolyphosphoric acid. At this time, it is necessary to use the phosphoric acid compound by >=10pts.wt. per 100pts.wt. CaO when the Ca compound is expressed in terms of CaO. Spherical anhydrous calcium secondary phosphate obtd. by said reaction has 0.6-1.0 average roundness, 0.4-0.7ml/g rate of liq. absorption, 10-50 deg. angle of repose, 1-100m<2>/g specific surface area and 1-100mum average particle size. This phosphate is entirely different from conventional common anhydrous calcium secondary phosphate in physical properties as well as shape. The conventional phosphate has 0-0.4 average roundness, 0.2-0.4ml/g rate of liq. absorption and 50-60 deg. angle of repose.
Our objectives were to ascertain the following: (1) the prevalence and socioeconomic distribution of hypertension (HTN), undiagnosed for HTN, and untreated cases of HTN-diagnosed individuals; (2) the relationship between SES and the prevalence of HTN, undiagnosed for HTN, and untreated for HTN; and (3) whether sex moderate this association. Data from the 2017-18 Bangladesh Demographic Health Survey were used. 11,776 participants who were 18 years of age or older responded to our analysis. The age-adjusted prevalence of HTN, undiagnosed for HTN, and untreated cases was 25.1%, 57.2%, and 12.3%. Compared to females, males were less likely to have HTN but more likely to have undiagnosed HTN. People in the rich SES groups had a higher odd of (adjusted odds ratio [aoR] 1.25; 95% confidence interval [CI] 1.08-3.45) of having HTN compared to those in the poor SES group. When compared to individuals in the poor SES group, those in the rich SES group had lower odds of undiagnosed (aoR 0.57; 95% CI 0.44-0.74) and untreated (aoR 0.56; 95% CI 0.31-0.98) for HTN. Sex moderated the association between SES and HTN prevalence, which showed that men from rich SES were more likely to suffer from HTN than men from poor SES. According to this study, the government and other pertinent stakeholders should concentrate more on developing suitable policy measures to reduce the risk of HTN, particularly for men in rich socioeconomic groups. They should also concentrate on screening and diagnosing HTN in socioeconomically disadvantaged populations, regardless of sex.
Parents will receive usual care for their child at Kaiser Permanente Colorado. This includes recommendations for well child visits at 2, 4, 6 and 12 months of age as well as automated reminders for age eligible children to receive the flu shot during flu season.
The goal of this pilot study is to find out whether an activity meter linked to web-based rewards will increase physical activity levels in middle school aged students who use it over 6 weeks. To test this, students who participate in the study will be assigned to 1 of 3 groups: the meter with web-based rewards group, the Dance Dance Revolution group, or the control group. The physical activity of participants in all 3 groups will be tracked using the an activity meter that participants will be asked to carry daily for the 6 weeks of the study. Participants given the activity meter with web-based rewards or Dance Dance Revolution will be instructed to use them at their own will, as much or as little as they like. Before beginning the study, all participating students will be asked background questions about themselves (such as their gender, age, and ethnic group) and about the kinds of computer and video game consoles they have access to at home. All participants will also complete short questionnaires at enrollment, week 1, week 3 and week 6. These questions will ask participants about their experiences using the assigned devices, their physical activity levels, and their thoughts about their ability to be physically active. At the end of 6 weeks, all participants will finish the study and return their assigned devices to the study coordinator. Height and weight will be measured at baseline and at the end of the study.
PURPOSE: To obtain an optically active dichloroaniline deriv. which has a selective stimulating effect on β 2 adorenergic receptor and a long effective period and which is useful for the treatment or prevention of diseases relating to reversible airway such as asthma and chronic bronchitis.  
     CONSTITUTION: This compd. is (R)(-)4-amino-3,5dichloroα-[[[6[2-(2pyridinyl) ethoxy] hexyl]amino] methyl] benzenemethanol or its physiologically acceptable salts. The compd. is used for the treatment of diseases which can be improved by a compd. having a selective β 2 -stimulating effect, and moreover, the compd. is used for the treatment or prevention of inflammation, allergy and allergic reaction. The compd. is produced by (A) deblocking a compd. expressed by formula I (R 1 , R 2  is H and at least one of these is a protecting group), or by (B) allowing a compd. expressed by formula II (K 3  is a protecting group) to react with a compd. expressed by formula III and then removing the protecting group, or by (C) reducing a compd. expressed by formula IV or its deriv. having protecting groups and then removing the protecting groups. 
     COPYRIGHT: (C)1993,JPO
The project will provide intensive counseling at the Centre for Health Promotion (CHP) of HKU Department of Nursing Studies, female smokers (including all types of tobacco products such as shisha, electronic cigarettes and heat-not-burn (HNB) which are available in the market) who require more intensive counseling or advice on nicotine replacement therapy, upon referral from the women's organizations and trained women counselors. The smokers will receive face-to-face (or telephone) counseling and a 1 week supply of Nicotine replacement therapy (NRT) (4 mg nicotine gum or 10 mg/ 15 mg nicotine patch) from the nurse counselor, and follow up calls at 1 week, 1-, 3-, 6-, 36- and 72-month post-intervention.
Drug-contg. fiber for retention in the gastro-intestial (GI) tract have a length/dia. ratio of at least 8, a dia. of at least 0.1mm and a length of at least 2mm.  The drug is present as a core or a soln. or suspension in the fibers.  The polymer is (a) permeable to GI fluid and opt. contains a porosigen, (b) bioerodable in GI fluid, (c) impermeable to the drug and GI fluid and contains a porosigen or (d) microporous.  The fibers provide controlled drug release in the upper GI tract.
In this study investigator planned to randomize patients into three groups ; in the first group abdominal entrance pressure will be 15 mmhg and intraoperative pressure will be 15 mmhg too ; in the second group again entrance pressure will be 15 mmhg , intraoperative pressure will be 12 mmhg ; and in the thirth group both entrance and intraoperative pressures will be 12 mmhg. During operation intraoperative mean pressures will be recorded every 15 minutes , also end tidal CO2 pressures will also assesed by the anesthesiologist. Every participant will take , same standard analgesics ; 2 mg/kg contramal and 1 gr i.v. paracetamol at the end of the operation ; except the ones who has allergy to these analgesics. At postoperative 6 th and 24 th hours patients will be asked to execute the visual analogue score (VAS) form to assess the pain . Only patients with benign gynecologic pathologies will be included in to the study and informed consent forms will be taken from all participants.
INTRODUCTION: Oslo University Hospital is a tertiary center conducting a significant number of transcatheter aortic valve implantation (TAVI) procedures per year. In this follow-up MediPace study, we aimed to investigate early echocardiographic changes in systolic and diastolic functions after TAVI in these patients.
METHODS: All patients enrolled in the previous study were contacted 3 months after TAVI for echocardiographic evaluation. Detailed echocardiography was performed 3.5 ± 1.6 months after TAVI, and compared with baseline evaluations.
RESULTS: A total of 101 patients were analyzed. Mean age was 80.1 ± 6.8 years and 40% of the patients were female. We observed a significant improvement in global longitudinal strain (GLS) (pre-TAVI -16.8 ± 4.1%, post-TAVI -17.8 ± 3.6%, p < .001), with no notable change in LVEF. More than half of the patients (52%) experienced a significant reverse remodeling with ≥10% decrease in left ventricular mass index (LVMi) following TAVI (pre-TAVI 123.6 ± 32.1 vs. 109.7 ± 28.9 g/m2 post-TAVI, p < .001). Pre-TAVI LVMi was a positive predictor, whereas history of HT was a negative predictor of LVMi reduction. There was no significant improvement in diastolic function following TAVI. Highest degree of paravalvular leakage was mild to moderate and was observed in only 2%.
CONCLUSIONS: A significant improvement in GLS and LVMi was found following TAVI. History of hypertension and baseline LVMi were predictors of LVMi change. There was no notable change in diastolic function, including left atrial strain.
OBJECTIVE: The aim was to research ACTL6A's role in oral squamous cell carcinoma (OSCC).
METHODS: OSCC and normal samples were obtained from patients and public databases. GSEA was performed. CIBERSORT was utilized to analyze immune landscape. Kaplan-Meier survival analysis and multivariate Cox regression analysis were conducted. After knocking down ACTL6A, we performed MTT assay, transwell assays, and flow cytometry to detect the impact of knockdown.
RESULTS: ACTL6A expressed higher in OSCC samples than normal samples. The CNV and mutation rate of TP53 was higher in ACTL6A high-expression group. TFs E2F7 and TP63 and miRNA hsa-mir-381 were significantly related to ACTL6A. ACTL6A could influence immune microenvironment of OSCC. Knockdown of ACTL6A inhibited OSCC cells' proliferation, migration, and invasion. ACTL6A was able to predict OSCC prognosis independently.
CONCLUSION: ACTL6A expressed higher in OSCC than normal samples and it could be used as an independent prognostic marker in OSCC patients.
We intend to photograph male and female subjects from age 1 through skeletal maturity. Healthy children will be photographed to determine the normative characteristics of thoracic function using this technique. We will also enroll patients with thoracic pathology to determine how digital imaging can document thoracic dysfunction. There are no specific disease related exclusion criteria. Participation is voluntary.
Paraffin 15g daily for 6 months. The dose may be modified depending on the number of total bowel movements, (the expected range is 2 - 4 per day).
Exogeneous ketones will be administered orally using monoester 3-OHB concentrate without added salts (25g 3-OHB in 65ml H.V.M.N Ketone Ester, H.V.M.N, USA or equivalent). The drink will be administered over 10 mins every 3 hours, 3 times in a row.
This rapid communication highlights the correlations between digital pathology-whole slide imaging (WSI) and radiomics-magnetic resonance imaging (MRI) features in triple-negative breast cancer (TNBC) patients. The research collected 12 patients who had both core needle biopsy and MRI performed to evaluate pathologic complete response (pCR). The results showed that higher collagenous values in pathology data were correlated with more homogeneity, whereas higher tumor expression values in pathology data correlated with less homogeneity in the appearance of tumors on MRI by size zone non-uniformity normalized (SZNN). Higher myxoid values in pathology data are correlated with less similarity of gray-level non-uniformity (GLN) in tumor regions on MRIs, while higher immune values in WSIs correlated with the more joint distribution of smaller-size zones by small area low gray-level emphasis (SALGE) in the tumor regions on MRIs. Pathologic complete response (pCR) was associated with collagen, tumor, and myxoid expression in WSI and GLN and SZNN in radiomic features. The correlations of WSI and radiomic features may further our understanding of the TNBC tumoral microenvironment (TME) and could be used in the future to better tailor the use of neoadjuvant chemotherapy (NAC). This communication will focus on the post-NAC MRI features correlated with pCR and their association with WSI features from core needle biopsies.
The present invention relates to homo- and hetero-dimer compounds formed by a disulfide, sulfinyl thio, or olefin bond between two monomers. A method of making a homo- or hetero-dimer compound is also disclosed. The present invention also relates to monomer compounds capable of forming homo- or hetero- dimer compounds, as well as oligomers formed via linkage of one or more dimers. Also disclosed are methods of inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-I RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules. The dimer compounds can also be used for selectively detecting presence of the target RNA molecule in a sample.
PURPOSE: A pharmaceutical composition comprising the extract of Ganoderma lucidum is provided, for promoting the generation of hard tissues such as bones and teeth. CONSTITUTION: The pharmaceutical composition comprises the extract of Ganoderma lucidum. The extract of Ganoderma lucidum is prepared by repeating the procedure consisting of heating the 50-100% methanolic aqueous solution containing Ganoderma lucidum at a temperature of 50-120°C for 5-24 hours, cooling the solution to 40-60°C, and filtering the solution; and concentrating the solution. The extract of Ganoderma lucidum is also prepared by repeating the procedure consisting of leaving the 50-100% methanolic aqueous solution containing Ganoderma lucidum at room temperature or at 4°C for 5-7 days, filtering the solution; and concentrating the solution. The extraction liquid is dried to obtain a powder. The composition comprises the extract of Ganoderma lucidum in the forms of a liquid or a powder. The composition promotes the proliferation of osteoblast and increases the activity of alkali phosphatase, thereby promotes the regeneration and proliferation of hard tissues, therefore can be used for treating or preventing osteoporosis or periodontitis. The composition can be used in the form of a toothpaste or a gargle. Also the composition can be used as an additive of the feed for a hatcher to strengthen the shell of an egg.
Uveal melanomas are melanocytic tumors that arise in the pigmented tissues of the eye: the iris, ciliary body, and choroid. Iris melanomas rarely metastasize (spread to other tissues or organs). In contrast, uveal melanomas arising in the ciliary body and choroid are highly malignant (cancerous and invasive to other tissues or organs). Despite having excellent local tumor control rates, uveal melanoma remains a life-threatening cancer, and even eye-sparing therapy with radiation treatment often leads to significant loss of vision. Therefore patients diagnosed with uveal melanoma must cope with not only a life-threatening illness, but also the frightening prospect of significant vision loss. Choroidal melanomas located in the posterior pole, an anatomical area of the eye which includes the optic nerve and macula (central retina), are of particular concern with regards to visual outcome, as radiation treatment to these areas for even the smallest of tumors is often associated with severe vision loss. The accurate diagnosis and treatment of small choroidal melanomas is critical to patient survival. When tumors with metastatic potential are recognized and treated at an early stage, survival prognosis improves dramatically.

The purpose of this study is to learn if malignant (life-threatening) choroidal tumors versus benign (non-life-threatening) tumors will show distinct blood vessel patterns using functional optical coherence tomography (OCT) angiography. Angiography is the mapping of blood vessels. The investigators believe that OCT angiography can provide data which may help in identifying life-threatening tumors at the earliest stages and improve overall survival for patients with this type of melanoma.
200,036. Imray, O. Y., (Soc. of Chemical Industry in Basle). Feb. 15, 1923. Medicines for internal use; medicaments for external application.-Emulsions of medicaments soluble in oil are made by dissolving the medicament in an oil which has been brought by partial halogenization to a specific gravity substantially equal to that of the emulsifying liquid which is subsequently added. In an example, bromine is dropped into cooled olive oil until the specific gravity of the product is 1.02. Equal parts of a twenty per cent solution of camphor in the product and of a dilute gum solution are stated to form a stable emulsion. Any other medicament soluble in oil may be similarly treated, and other emulsifying agents, such as sodium caseinate, may be used.
Substantially pure human cyclin-dependent kinase-like proteins PITALRE and PISSLRE and isolated protein complexes that comprise PITALRE or PISSLRE are disclosed. Isolated nucleic acid molecule that encode PITALRE or PISSLRE or a fragment thereof; recombinant expression vectors that comprise nucleic acid sequences that encode PITALRE or PISSLRE; and host cells that comprise such recombinant expression vectors are disclosed. Oligonucleotide molecules that consist of a nucleotide sequence complimentary to a portion of the nucleotide sequence that encodes PITALRE or PISSLRE are disclosed. Antibodies which bind to epitopes on PITALRE or PISSLRE are disclosed. Nucleic acid molecules that comprises a nucleotide sequence that encodes phosphorylation deficient PITALRE or a phosphorylation deficient PISSLRE; recombinant vectors and pharmaceutical compositions that comprise such nucleotide sequences are also disclosed. Methods of identifying compounds which inhibit PITALRE activity are disclosed.
This is a 52 week non-placebo controlled and non-randomized clinical research study to see whether treating Major Depressive Disorder (MDD) in caregivers of children with asthma will improve asthma outcomes in children. Caregivers may choose to receive an antidepressant medication that is considered standard medical care for MDD, or may opt out of antidepressant treatment. No treatment is withheld from participants and no placebos are used, thus there is no active intervention in this study.