anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Patients with Barrett's esophagus are advised to undergo periodic endoscopic surveillance with random biopsies in an attempt to identify high-grade dysplasia (HGD) or early adenocarcinoma (ACA) at a time when intervention can be curative. This approach, however, can be time-consuming and is hindered by low sampling yield and random sampling error. Endoscopic Tri-Modal Imaging (ETMI) is a novel diagnostic modality that encompasses three advanced imaging features in one system: high-resolution endoscopy (HRE), autofluorescence imaging (AFI) and narrow-band imaging (NBI). HRE and AFI provide a bird's-eye view of 'red flag' areas which are then assessed by NBI for focused and more specific tissue characterization. The aim of this prospective, multi-center study is to compare the diagnostic performance of ETMI with that of standard white-light endoscopy (WLE) for identifying high-grade dysplasia (HGD) and early adenocarcinoma (ACA) in BE. A total of 84 BE patients will be recruited for the study and they will undergo both ETMI and WLE examinations in a randomized, crossover fashion. Standard surveillance biopsies and ETMI-targeted biopsies will be performed. The primary outcome will compare the number of patients and lesions with HGD or early ACA detected with WLE and ETMI. It is anticipated that ETMI will enhance the detection of high-grade Barrett's lesions relative to WLE.
Postural abnormalities represent disabling and painful complications in patients with Parkinson's disease (PD). The first postural trunk deviation in PD was first described by James Parkinson himself and recognized as stooped simian appearance, with flexion of the hips and knees, and rounding of the shoulders. Although the stooped posture is a typical feature, more severe spinal misalignment (and deformities) can affect people with PD. These postural deformities include Pisa syndrome (PS), camptocormia (CP), antecollis (AC), scoliosis (S) and striatal deformities related to hand (striatal hand) and/or toes (striatal toes). The prevalence of these postural deformities is variable because several diagnostic criteria have been used to characterize each deformity. Recently, a consensus of diagnostic criteria has been reached in literature permitting us to better mapping the presence of these deformities in people with PD.
Fifty four subjects with class II division 2 participated in this study. The subjects were randomly divided into two groups; Group one (28 patients): orthodontic treatment with upper arch bond up first and lower arch was bonded when 4 mm overjet was reached. The treatment continued until 0.019 x 0.025 " stainless steel wires were reached in both arches. Group 2 (26 patients): orthodontic treatment with lower arch bond up first with removable anterior bite plane in upper arch. When 0.019 x 0.025" stainless steel wire was reached, the upper arch was bonded. The treatment continued until 0.019 x 0.025" stainless steel wires were reached. Three cephalograms were taken for each patient in both groups; pretreatment (T0) , after bonding the other arch (T1) and at the end of leveling and alignment in both arches (T2). Cephalometric measurements and superimpositions were made. Skeletal and dentoalveolar treatment changes were compared within and between the 2 groups.
As part of the study patients will undergo 3 additional MR scans during radiotherapy treatment. These will take place in the 1st, 2nd and 5th weeks of treatment.
FIELD: pharmacology. ^ SUBSTANCE: invention concerns indazol derivatives of general formulae (I) or (II) , where radicals and groups are defined as shown in cl. 1 of invention claim, and their pharmaceutically acceptable salts. Also invention claims medicine, method of medicine obtainment and application of claimed compounds in treatment and/or prevention of fatty acid metabolism derangement and glucose assimilation disorders. ^ EFFECT: inhibition of hormone-sensitive lipases. ^ 13 cl, 1 tbl, 103 ex
Obliterative surgical procedures have been classically used as a method to reduce pelvic organ prolapse in elderly women who do not wish to preserve the vagina for sexual intercourse. The aim of this video is to demonstrate a surgical technique of repairing complete labia majora fusion in a woman who had previously undergone one of these procedures. We present the case of an 80 year-old woman with a history of progressive difficulty on voiding onset and sensation of incomplete bladder emptying. She reported an obliterative procedure to correct her pelvic organ prolapse (POP) 10 years earlier. On physical examination, complete fusion of labia majora was observed, causing abnormal urinary drainage. Perineal reconstructive surgery was performed without complications and the application of topical Promestriene was prescribed. Optimal genital re-epithelization was observed during follow-up. As observed, patients undergoing obliterative surgery who present with genital atrophy are at increased risk of developing vulvar adherences. Applying vaginal moisturizers or local topical estrogens can prevent this condition. In severe vulvar fusions, early surgical treatment is recommended to prevent potentially serious complications.
The invention discloses a levalbuterol sulfate pulsatile capsule, which undergoes pulsatile release in the gastrointestinal tract environment. A preparation comprises levalbuterol sulfate and a pharmaceutically-acceptable polymer. The preparation comprises the following components in percentage by weight: 2-25 percent of the levalbuterol sulfate, 15-45 percent of styrene sulfonic acid-methacrylic acid copolymer and the balance auxiliary materials. A brand new styrene sulfonic acid-methacrylic acid copolymer plays a role in realizing the pulse action. Compared with an ordinary preparation, a pulsatile preparation has the advantages that: the levalbuterol sulfate is released after the preparation is taken for 3-4 hours, the peak time of the medicament is consistent with the disease time, the aim of performing chrono-chemotherapy can be fulfilled, and side effects such as tolerance, zero time effect, rebound phenomenon and the like are reduced. The pulsatile capsule is taken as a cough-relieving medicament clinically.
BACKGROUND: Sacral neuromodulation (SNM) is an effective approach for treating lower urinary tract dysfunction (LUTD), and stimulation programming is essential for successful treatment. However, research on SNM programming for various indications is limited. Thus, the authors aimed to determine whether there were differences in the stimulation parameters for different SNM indications and the appropriate programming recommendations.
MATERIALS AND METHODS: Clinical data were retrospectively collected from patients with LUTD who underwent SNM and completed internal pulse generator implantation. The parameters with the highest patient satisfaction or the most symptom improvement during the test period were considered optimal and used to set the programming after internal pulse generator implantation.
RESULTS: After screening, 282 patients were enrolled and categorized into four groups based on the following indications: refractory overactive bladder (OAB) ( n =61), neurogenic lower urinary tract dysfunction (nLUTD) ( n =162), interstitial cystitis/painful bladder syndrome (IC/BPS) ( n =24), and idiopathic nonobstructive urinary retention (NOUR) ( n =35). When analyzing the optimal stimulus parameters, disparities in the stimulation amplitude and pulse frequency were noted among the four groups. The stimulation amplitude in the nLUTD group was higher than that in the idiopathic NOUR group ( P =0.013). Differences in pulse frequency were observed between the refractory OAB and nLUTD groups ( P <0.001) and between the refractory OAB and idiopathic NOUR groups ( P =0.001). No differences in the electrode configuration or pulse width settings existed among the four groups.
CONCLUSIONS: The stimulation parameters for SNM varied among the different indications. For the initial programming of stage I, most patients are recommended to start with stimulation amplitudes below 2 V, although patients with nLUTD may benefit from higher amplitudes. A standard pulse width of 210 μs is recommended for all patients. However, for individuals experiencing nLUTD or idiopathic NOUR, the pulse frequency can begin above the standard 14 Hz but not exceed 50 Hz.
The invention relates to a shoe pad capable of preventing and curing hypertension. The shoe pad has two characteristics of being attractive and having medical effects. The shoe pad is based on sachets and embroidery of Qingyang, Gansu, highlights folk embroidery skills, and absorbs folk Chinese herbal medicine secret recipes, fragrance formulas and the like. The shoe pad has the medical effects of promoting blood circulation and removing stasis, being fragrant, and clearing damp and relieving itching, has natural fragrance, makes full use of heat and sweat generated by human bodies, and promotes mixed components of Chinese herbal medicine and fragrance to volatilize towards the direction of the human bodies. Pure cotton cloth contacting the human bodies is good in permeability and favorable for body surfaces to absorb and use the Chinese medicine components. The shoe pad capable of preventing and curing the hypertension is extension of functions and technology of Qingyang sachet products.
FIELD: biotechnology, medicine, pharmacy. SUBSTANCE: recombinant human erythropoietin is prepared by culturing transformed cells CHO producing recombinant erythropoietin in hollow-fiber bioreactors. Method involves repeated inoculation of bioreactors in 7 days, incubation of cellular culture for 16 h up to density value 2•10 6  cells/ml and onset of fermentation process by continuous perfusion for up to 60 days followed by collection of supernatant enriched with recombinant erythropoietin and centrifugation of cultural medium. Purification of supernatant and fraction is carried out by affinity and ion-exchange chromatography. Recombinant erythropoietin shows 98% of purity degree, biological activity 160 IU/mg and used in pharmaceutical composition for treatment of anemia. Invention provides preparing recombinant human erythropoietin with high specific activity and elimination from blood and highly effective for therapeutic application. Invention is used for preparing recombinant human erythropoietin. EFFECT: improved preparing method, valuable properties of erythropoietin. 4 cl, 9 dwg, 6 ex
After being informed about the study and giving consent, participants will enroll in a program that collects data at enrollment, at the end of the program, and 12 months following program enrollment. The length of the program ranges from four weeks up to one year, depending on the setting and the number of optional workshops students opt to receive. Research questions in this study are framed by a descriptive evaluation design to assess whether outcomes improve for at-risk youth who participate in the IVROP ReadyforLIFE program. Primary and secondary outcomes are assessed before and one year after participants complete core curricula - Relationships Smart Plus, Mind Matters, and Money Habitudes (pre to follow-up). Primary outcome measures will indicate whether behavior improved for healthy partner relationships and financial stability. Secondary outcome measures will indicate whether improvements were made in the attitudes and expectations that facilitate and reflect behavior for healthy partner relationships and financial stability.
PROBLEM TO BE SOLVED: To obtain a sebum secretion depressor capable of exhibiting a suppressing or preventing effect on local accumulation of fat and improving a beauty appearance of the skin by using a specific compound obtained from escin in the extract of the seed of Aesculus hippocastanum as an active component. SOLUTION: This sebum secretion depressor contains escinol or its salt expressed by the formula (R<1> is H or OH; R<2> is a pyranol residue) as an active component. Escinol is a triterpenoid-based saponin obtained by alkali- decomposition of escin in an extract of a seed of Aesculus turbinata and removing an acyl group, e.g. R<2> of OH and R<2> of β-D-glucopyranose, R<1> of OH and R<2> of β-D-xylopyranose, and R<1> of H and R<2> of β-D-galactopyranose are exemplified. Preferably, a containing amount of the escinol or its salt in this depressor is about 0.001-20wt.%, especially 0.1-7wt.% based on the total amount. The preparation for external use has an effect on seborrheric disease such as a pimple induced by hypersecretion of sebum and a seborrherric handruff.
The invention discloses a pharmaceutic preparation for treating fowl diarrhea and a using method thereof. The pharmaceutic preparation is prepared from, by weight, 40-70 parts of berberine, 8-11.5 parts of montmorillonite powder, 4-7 parts of gentamicin, 4-7.5 parts of sodium chloride, 3.5-5 parts of potassium chloride, 2-3 parts of sodium acetate, 4-8 parts of glycine, 8-12.5 parts of yeast cell walls, and 0.5-1.5 parts of silicon dioxide. Raw materials are put into a mixer in sequence to generate the solid powdery mixed preparation. The using method comprises the steps of dissolving the pharmaceutic preparation in warm water which is 35-40 DEG C, and then conducting stirring for 0.5-2 min, so that a solution with the pharmaceutic preparation concentration being 35-45 g/L is obtained. The dosage is that 0.5-1.5 L pharmaceutic preparation is adopted each time for each fowl suffering from diarrhea based on the frequency of 2-4 times a day, and the pharmaceutic preparation is fed to the fowl continuously for 1-3 days. For fowls suffering from diarrhea, quick and effective supplement of body fluid can be achieved by the pharmaceutic preparation, and acidosis of body liquid can be treated.
BACKGROUND: Liver fibrosis contributes to significant morbidity and mortality in Western nations, primarily attributed to chronic hepatitis C virus (HCV) infection. Hypoxia and immune status have been reported to be significantly correlated with the progression of liver fibrosis. The current research aimed to investigate the gene signature related to the hypoxia-immune-related microenvironment and identify potential targets for liver fibrosis.
METHOD: Sequencing data obtained from GEO were employed to assess the hypoxia and immune status of the discovery set utilizing UMAP and ESTIMATE methods. The prognostic genes were screened utilizing the LASSO model. The infiltration level of 22 types of immune cells was quantified utilizing CIBERSORT, and a prognosis-predictive model was established based on the selected genes. The model was also verified using qRT-PCR with surgical resection samples and liver failure samples RNA-sequencing data.
RESULTS: Elevated hypoxia and immune status were linked to an unfavorable prognosis in HCV-induced early-stage liver fibrosis. Increased plasma and resting NK cell infiltration were identified as a risk factor for liver fibrosis progression. Additionally, CYP1A2, CBS, GSTZ1, FOXA1, WDR72 and UHMK1 were determined as hypoxia-immune-related protective genes. The combined model effectively predicted patient prognosis. Furthermore, the preliminary validation of clinical samples supported most of the conclusions drawn from this study.
CONCLUSION: The prognosis-predictive model developed using six hypoxia-immune-related genes effectively predicts the prognosis and progression of liver fibrosis. The current study opens new avenues for the future prediction and treatment of liver fibrosis.
Postmortem interval (PMI) estimates the time since death. Teeth are perennial elements capable of remaining intact in taphonomic environmental circumstances. The objective was to evaluate the feasibility of estimating the minimum postmortem interval (PMImin) through histological analyses of dental tissues exposed to burial and drowning conditions, simulating common scenarios in forensic practice. A total of n = 99 teeth were analyzed and divided into four groups: control (T0), one month (T1), three months (T2), and six months (T3). The control sample comprised 10 teeth, while T1, T2 e T3 were divided into three different subgroups: controlled environment, buried, and drowned. For each subgroup, ten samples were used. Following exposure to taphonomic conditions, the specimens were processed, and histological sections were obtained. The two-way ANOVA test and the Tukey's post-hoc test were employed for the quantitative analysis of dentin collagen fibrils, revealing statistically significant differences (α = 5 %). This allowed for the estimation of the PMImin at three months by observing pixel counts exceeding 13e+05 in drowned teeth and greater than 8e+05 in buried teeth. Qualitative analysis revealed that the PMImin of drowned teeth was estimated at one month due to the absence of the periodontal ligament (PDL) and at six months due to the absence of predentin and partial degradation of the cementum. For buried teeth, the three-month PMImin was indicated by the absence of PDL and partial cementum degradation. The absence of pulp and remnants of predentin characterized the six-month PMImin. Qualitative and quantitative histological characteristics and parameters are potential to estimate PMImin in forensic scenarios spanning up to six months.
BACKGROUND: The subjective sign of a serious pandemic in human work and life is mathematical neural tinnitus. fNIRS (functional near-infrared spectroscopy) is a new non-invasive brain imaging technology for studying the neurological activity of the human cerebral cortex. It is based on neural coupling effects. This research uses the fNIRS approach to detect differences in the neurological activity of the cerebral skin in the sound stimulation mission in order to better discriminate between the sensational neurological tinnitus.
METHODS: In the fNIRS brain imaging method, 14 sensorineural tinnitus sufferers and 14 healthy controls listened to varied noise and quiet for fNIRS data collection. Linear fitting was employed in MATLAB to eliminate slow drifts during preprocessing and event-related design analysis. The false discovery rate (FDR) procedure was applied in IBM SPSS Statistics 26.0 to control the false positive rate in multiple comparison analyses.
RESULTS: When the ill group and the healthy control group were stimulated by pink noise, there was a significant difference in blood oxygen concentration (P < 0.05), and the healthy control group exhibited a high activation, according to the fNIRS measurement data. The blood oxygen concentration level in the patient group was dramatically enhanced after one month of acupuncture therapy under the identical stimulation task settings, and it was favorably connected with the levels of THI and TEQ scales.
CONCLUSIONS: Using sensorineural tinnitus illness as an example, fNIRS technology has the potential to disclose future pathological study on subjective diseases throughout time. Other clinical disorders involving the temporal lobe and adjacent brain areas may also be examined, in addition to tinnitus-related brain alterations.
1. Technical Result Increase in stability and reduce of hygroscopicity.         2. Essence Eletriptan hydrobromide monohydrate of the formula (I)   method for preparation, pharmaceutical composition containing the same, its use for treatment of migraine, hypertension, depression, emesis, anxiety, an eating disorder, obesity, drug abuse, cluster headache, chronic paroxysmal hemicrania and headache associated with a vascular disorder.         3. Field of Application Medicine.
Severe mucocutaneous reactions, some with fatal outcome, such as Stevens-Johnson syndrome and Toxic Epidermal Necrolysis (TEN) can occur in patients treated with Capecitabine [see Adverse Reactions (6.4)]. Capecitabine should be permanently discontinued in patients who experience a severe mucocutaneous reaction possibly attributable to Capecitabine treatment.

Hand-and-foot syndrome (palmar-plantar erythrodysesthesia or chemotherapy-induced acral erythema) is a cutaneous toxicity. Median time to onset was 79 days (range from 11 to 360 days) with a severity range of grades 1 to 3 for patients receiving Capecitabine monotherapy in the metastatic setting. Grade 1 is characterized by any of the following: numbness, dysesthesia/paresthesia, tingling, painless swelling or erythema of the hands and/or feet and/or discomfort which does not disrupt normal activities. Grade 2 hand-and-foot syndrome is defined as painful erythema and swelling of the hands and/or feet and/or discomfort affecting the patient’s activities of daily living. Grade 3 hand-and-foot syndrome is defined as moist desquamation, ulceration, blistering or severe pain of the hands and/or feet and/or severe discomfort that causes the patient to be unable to work or perform activities of daily living. Persistent or severe hand-and-foot syndrome (grade 2 and above) can eventually lead to loss of fingerprints which could impact patient identification. If grade 2 or 3 hand-and-foot syndrome occurs, administration of Capecitabine should be interrupted until the event resolves or decreases in intensity to grade 1. Following grade 3 hand-and-foot syndrome, subsequent doses of Capecitabine should be decreased [see Dosage and Administration (2.3)].
The patients were positioned in supine with adjustable lumbar, and thoracic belts attached to the traction cord. After tightening the belts, the M7 position was selected to achieve hip and knee flexion, and posterior pelvic tilt of 25° was added. Before starting the therapy, the weight of the subject was entered in the panel, and a short tolerance test was carried out. Patients were provided with a manual switch to stop treatment any time. Preset lumbar disc herniation protocol was used. Each session lasted fifteen minutes, applied force had 100-gram step increments, and did not exceed 50% of the weight of the patient. At the end of the therapy, the cord was disconnected and belts were removed. Participants were asked to sit for three minutes to identify any adverse reaction.
PURPOSE: To obtain a solid medicine compsn. which is obtd. by granulating and freeze-drying and which enables preparation of a stable suspension liquid. CONSTITUTION: A suspension liquid containing a phospholipid and a polyethylene glycol (preferably having 3000 to 4000 mol.wt.) in a ratio of 1:1 to 1:10, especially 1:1 to 1:3 is prepared, to which 4-hydroxy-4-androsten-3,17-dione is added and stirred. the obtd. suspension liquid is granulated in an ultrasonic pulverizing device to obtain fine particles having 2 to 20 μm particle size. preferably 3 to 6 μm. Then the suspension is freeze-dried to obtain a solid medicine compsn. which can form a stable suspension liquid.