anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a cosmetic, good in dispersibility and having high effects on protection of the skin against ultraviolet rays and high stability with time by treating the surfaces of fine partiulate titanium oxide and fine particulate zinc oxide with a silicone oil agent, chemically bonding the silicone to the surfaces and using the resultant surface-treated materials at a specified ratio. SOLUTION: This cosmetic contains fine particulate titanium oxide and fine particulate zinc oxide respectively treated with a silicone preferably at a weight ratio of (9.8:0.2)-(5:5), preferably (9:1)-(6:4), more preferably (8:2)-(6.8:3.2). The fine particulate titanium oxide comprising secondary flocks having 0.5-3.0μm average particle diameter and the fine particulate zinc oxide comprising secondary flocks having 0.2-3.5μm average particle diameter are especially used. The total amount of fine particulate titanium oxide and fine particulate zinc oxide is regulated to 0.5-12.5wt.%, preferably 1.0-10wt.% based on to the whole cosmetic. The fine particulate titanium oxide treated with the silicone is obtained by pulverizing or disintegrating titanium oxide with a jet gas stream and simultaneously adsorbing or bonding the silicone thereto.  The zinc fine particlulate zinc oxide treated with the silicone is prepared in a similar way.
Subjects who had previously received the Tick borne encephalitis (TBE) primary vaccination according to rapid (R) schedule i.e., on days 0, 7 (+3) and 21 (+7) in the parent study (V48P7) and who were administered 1 booster dose of Encepur adults either 12-18 months after R schedule completion or in the first extension study, V48P7E1 (NCT00387634), were included in this group. Subjects had blood drawn annually starting from year 6 up to year 10 after booster vaccination (for those subjects boostered before V48P7E1 study start, the blood draw occurred annually starting from \>6 years up to \>10 years after booster vaccination).
Anxiety disorders have tremendous disease burden in the United States. Up to 1 in 3 Americans will be diagnosed with an anxiety disorder in their lifetimes. Anxiety treatment is typically consisting of psychotherapy (e.g. cognitive behavioral therapy) and medication management (e.g. benzodiazepines, selective serotonin reuptake inhibitors, etc). With major depressive disorder, rTMS is a suitable alternative treatment for refractory depression, rTMS is not approved for treatment of anxiety, nor can rTMS stimulate deep enough to reach those brain circuits involved in anxiety (e.g. the amygdala). Focused ultrasound is a new treatment modality being developed for several different neuropsychiatric conditions. In this study, the investigators propose to randomize 48 individuals to either active or sham treatment. Each participant will be evaluated to establish a baseline diagnose of generalized anxiety disorder, and then will be reassessed after each treatment session (of which there are four). One week and one month after the last treatment session, the investigators will conduct follow-up evaluations.
BACKGROUND AND PURPOSE: The objective is to demonstrate feasibility of quantitative susceptibility mapping (QSM) in autosomal dominant polycystic kidney disease (ADPKD) patients and to compare imaging findings with traditional T1/T2w magnetic resonance imaging (MRI).
METHODS: Thirty-three consecutive patients (11 male, 22 female) diagnosed with ADPKD were initially selected. QSM images were reconstructed from the multiecho gradient echo data and compared to co-registered T2w, T1w, and CT images. Complex cysts were identified and classified into distinct subclasses based on their imaging features. Prevalence of each subclass was estimated.
RESULTS: QSM visualized two renal calcifications measuring 9 and 10 mm and three pelvic phleboliths measuring 2 mm but missed 24 calcifications measuring 1 mm or less and 1 larger calcification at the edge of the field of view. A total of 121 complex T1 hyperintense/T2 hypointense renal cysts were detected. 52 (43%) Cysts appeared hyperintense on QSM consistent with hemorrhage; 60 (49%) cysts were isointense with respect to simple cysts and normal kidney parenchyma, while the remaining 9 (7%) were hypointense. The presentation of the latter two complex cyst subtypes is likely indicative of proteinaceous composition without hemorrhage.
CONCLUSION: Our results indicate that QSM of ADPKD kidneys is possible and uniquely suited to detect large renal calculi without ionizing radiation and able to identify properties of complex cysts unattainable with traditional approaches.
Disclosed is a pyrroloazepine derivative or a salt thereof.  The pyrroloazepine derivative is represented by the following formula (I):     (see fig. I) wherein the ring P represented by   (see fig. II) means a pyrrole ring represented by the following structure:     (see fig. III)   or     (see fig. IV) in which R1 represents alkyl, cycloalkyl or the like, and R2 represents H or alkyl; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present/and Z1 represents H but, when the bond is absent, Z1 and Z2 are both H; Z1 represents H and Z2 represents a group OR3 in which R3 represents H, alkyl, aralkyl or the like; Z1 and Z2 both represent groups SR4 in which R4 represents alkyl, aralkyl or the like; or Z1 and Z2 are combined together to represent O, a group NOR5 in which R5 represents H, alkyl or the like, or a C2-C3 alkylenedithio; A represents alkylene, alkenylene or alkynylene; and Y represents a group (see fig. V) in which W represents CH, C= or N, m stands for 0 or 1, n stands for 1, 2 or 3, G represents O, S, C=O, sulfinyl, sulfonyl, alkylene, alkenylene, acetal or the like; E1 and E2 represent H or lower alkyl group; and D represents an aromatic hydrocarbon or am aromatic heterocyclic ring.  The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is useful as a therapeutic for circulatory diseases such as ischemic heart diseases, cerebrovascular disturbances and peripheral circulatory disturbances.
The objective of this study was to determine the risk factors associated with Elizabethkingia anophelis infection in neonates admitted to a tertiary care neonatal intensive care unit (NICU). A case-control study was undertaken as part of the outbreak investigation for E. anophelis sepsis in a tertiary care NICU in South India. Thirty-eight neonates with E. anophelis bloodstream infection (BSI) between January 2021 and February 2022 were enrolled as cases, and 38 neonates symptomatic with other BSIs, were selected as controls, and risk factors analysed. The 38 cases were relatively stable neonates, likely to be admitted to level 1 and level 2 NICU, unlike the controls, who were sicker and required level 3 NICU care. Only a third of neonates with Elizabethkingia sepsis had traditional risk factors like central lines, need for respiratory support or perinatal risk factors. Multiple logistic regression analysis revealed that neonates with E. anophelis infection were more likely to be stable and on only enteral feeds, cared in level 1 or 2 of the NICU. This observation, combined with isolation of Elizabethkingia meningosepticum from breast pumps earlier, led us to autoclave the feeding vessels and milk containers along with provision of hot water for cleaning breast pumps, and adoption of general infection control measures, after which incident cases declined. Sanger sequencing of 10 representative isolates obtained from the neonates showed 100% sequence identity to E. anophelis. Infection due to E. anophelis affects relatively stable neonates without traditional risk factors for sepsis. Adherence to asepsis routines and housekeeping protocols helps to prevent the spread of infection.
Overactive bladder syndrome (OAB), with or without urge incontinence, is characterized by urinary urgency, frequency and nocturia. Thus, patients with OAB could be considered to have a reduced quality of life. Patients with overactive bladder syndrome have a higher risk of falling and fracture due to nocturia. OAB affects around 17 % of female population. At present, muscarinic receptor antagonists are the ﬁrst-line pharmacotherapeutic agents for OAB. However, discontinuation of the treatment often results in symptom relapse. Until now, optimal duration of the treatment and durability of the efﬁcacy have not been determined. We plan to use urodynamic studies outcome to evaluate therapeutic effect, with the change of urinary nerve growth factor level. This study is a randomized prospective study, comparing female OAB patient after 3 months and 6 months of antimuscarinic treatment.

The purpose of this study is to investigate the difference of urodynamic effects, therapeutic effect and urinary urinary nerve growth factor level between OAB females after 3 months and 6 months antimuscarinic treatment.
Obesity is a complex chronic metabolic disorder characterized by abnormalities in lipid metabolism. Obesity is not only associated with various chronic diseases but also has negative effects on physiological functions such as the cardiovascular, endocrine and immune systems. As a global health problem, the incidence and prevalence of obesity have increased significantly in recent years. Therefore, understanding assessment methods and measurement indicators for obesity is critical for early screening and effective disease control. Current methods for measuring obesity in adult include density calculation, anthropometric measurements, bioelectrical impedance analysis, dual-energy X-ray absorptiometry, computerized imaging, etc. Measurement indicators mainly include weight, hip circumference, waist circumference, neck circumference, skinfold thickness, etc. This paper provides a comprehensive review of the literature to date, summarizes and analyzes various assessment methods and measurement indicators for adult obesity, and provides insights and guidance for the innovation of obesity assessment indicators.
Deep breathing exercises (5 minutes) Breathing is held for 4-5 seconds after deep inspiration. While the arms are brought to the normal position, exhale slowly and rhythmically. When expressing after deep inspiration, the lips can be pursed as if whistling or exhaled with laughter.
The HYAJOINT Plus group received one intraarticular injection of 3 ml HYAJOINT Plus and be followed for 52 weeks. A single injection of HYAJOINT Plus was performed if criteria was met at 52 weeks, and a 4-weeks follow-up of adverse events was conducted.
Subjects assigned to this arm will have their skin gently stroked twice daily for the time that would be required to apply an oil. This will simulate the stroking received by the intervention arm subjects. This will occur from enrollment until discharge, or until day of life 28, whichever occurs first.
The invention provides a whitening and face beautifying cosmetic. The whitening and face beautifying cosmetic contains schisanhenol, micro collagens, a rose elite extract liquid, glutathion peroxidase, L-Vitamin C and natural dew, and the natural dew substitutes original water. The schisanhenol is a main component of a Chinese magnoliavine extract, and can effectively prevent oxidation and inhibit the generation and release of substances comprising superoxide anions, hydrogen peroxide, lipid peroxide malonaldehyde and the like in neutral cells. The micro collagens can improve the regeneration capability of cells, so a whitening effect can be realized. The glutathion peroxidase ha a moisture retention function to make skins have enough water. The L-Vitamin C has the effect of a reducing agent, so melanin can be reduced to form tyrosine. The natural dew can supplement water to the cells of skins to make the skins soft, fine, moist and elastic, can reduce internal heat, and has a certain antibiotic effect.
Epstein-Barr virus (EBV) is the cause of heterophile-positive infectious mononucleosis. After primary EBV infection, the virus persists in resting memory B lymphocytes and can be detected in oropharyngeal secretions. Short term (1 month) treatment with oral acyclovir, which inhibits EBV replication, results in loss of virus shedding from the oropharynx, but the virus persists in B cells. The goal of this study is to determine if EBV will no longer persist in B cells in patients treated with long term (20 month) oral valaciclovir (which is metabolized to acyclovir). Blood samples and throat washings will be obtained every three months from individuals who are receiving valaciclovir for treatment of genital herpes simplex virus infection. These samples will be analyzed for EBV DNA to determine if the level of EBV DNA declines or becomes negative with long term antiviral therapy. If the level of EBV DNA becomes undetectable in EBV-seropositive persons during the study, we will ask the patients to return twice a year for five years or if they develop symptoms of mononucleosis, so that EBV DNA in their blood and throat washings can be studied. Knowledge gained from this study should provide important insights into the mechanism of persistence of EBV infection.
A server is configured to send out requests for quotes to a number of regional shipping companies using a network. The server receives responses from the network and selects a route based on the responses. The route may include shipping the item to one or more intermediate destinations before the item arrives at the final destination. The server may create a data file reflecting the selected route. The items are packed in one or more containers (40), wherein each container has a memory device (50). At least part of the data file is then stored into the memory device. The memory device may be accessed as needed during shipping to determine where the item is going and when the item needs to arrive. Additional information may also be stored in the memory device, and the device may be updated at intermediate destinations. Each container may take a different routing, and the server may actively search for better routings as the item proceeds along the selected route. The containers may be configured to be placed within carriers (30) that hold multiple containers, and the carriers may be configured with memory devices (60). The container may include environmental sensors, a microprocessor, and a power supply (e.g., battery or solar panel). The processing apparatus is configured to interface with the memory device (e.g., using a wireless link) and read the memory device to determine how the item should be routed. The apparatus may be hand-held or built into a stationary apparatus such as a conveyer belt or an automated loading and unloading station. The apparatus may also include a scale to weigh the item in the container, and one or more digital cameras to capture images of the container and item. The apparatus may interface with a central server, an d may update the contents of the memory device based on information from the server (e.g., to reflect a new final destination).
The invention discloses a traditional Chinese medicine, syrup and paste for treating bone fracture and preparation methods thereof. The traditional Chinese medicine comprises the following raw herbal materials: venenum bufonis, borneol, hen egg membrane, pepper, radix clematidis, radix aconite, geosaurus, pyritum, cassia twig, cortex acanthopanacis, radix angelicae sinensis, radix aconiti kusnezoffii, turmeric, radix gaultheriae, radix arnebiae, rhizoma acori tatarinowii, cinnamon, stigma croci, frankincense, sambucus williamsii and all-grass of ames vanda. The traditional Chinese medicine has the beneficial effects that the traditional Chinese medicine can effectively relive or eliminate the pain which is caused by supportive splint fixation, plaster fixation and surgical traction when orthopedic patients suffer from bone fracture, activates the osteoblasts of the endosteum and periosteum of an orthopedic fracture end to quickly calcify so as to promote the new bone growth, and has a special effect. The traditional Chinese medicine has effects on activating blood and dissolving stasis, promoting the reunion of fractured bones, nourishing the liver and kidney, relieving swelling and pain and promoting focus repair. The traditional Chinese medicine is suitable for treating various orthopaedics and bone fractures and low in raw herbal material cost, has a good curative effect, a short curative effect, high cure rate and no toxic and side effects. The preparation method of the traditional Chinese medicine is simple in technology and easy to popularize.
PURPOSE: A wet tissue is provided to ensure strong antibacterial properties by intrinsic function of Chamaecyparis sp. essential oil without a chemical antiseptic and to ensure a natural dispersing using distilled lower aqueous layer liquid obtained when extracting the Chamaecyparis sp. essential oil. CONSTITUTION: A wet tissue (10) with vegetable antibacterial and deodorizing functionality using Chamaecyparis sp. essential oil without a chemical antiseptic or an emulsifier contains distilled lower aqueous liquid layer which is prepared when distilling and extracting Chamaecyparis sp. or Chamaecyparis sp. leaves and is applied to a paper or a fabric for a wet tissue. The distilled lower aqueous liquid layer contains 1-30 ppb of natural VOC (volatile organic compound, NVOC) which is naturally dispersed. A method for manufacturing the wet tissue comprises the steps of: extracting essential oil from Chamaecyparis sp. or Chamaecyparis sp. leaves; separating exclusively the lower aqueous liquid layer of the upper essential oil layer liquid; and impregnating the lower aqueous liquid layer to a dry wet tissue and packaging.
Powdery mildew infection is a significant challenge in butternut squash (Cucurbita moschata) production during winter in Hainan, China. The tropical climate of Hainan promotes powdery mildew infection, resulting in substantial yield losses. By utilizing transcriptome and genome sequencing data, SNPs and potential genes associated with powdery mildew resistance in butternut squash were identified. The analysis of differentially expressed genes (DEGs) following powdery mildew infection revealed several genes involved in resistance, with particular focus on a resistance (R) gene cluster that may be linked to the observed resistance. Two MLO genes in clade V from Cucurbita moschata may not be directly associated with resistance in the two genotypes studied. These findings are expected to contribute to the development of genetic tools for improving powdery mildew resistance in Cucurbita crops, thereby reducing yield losses and enhancing the sustainability of butternut squash production in Hainan and other regions.
BACKGROUND: Heart transplantation is relatively contraindicated in morbidly obese patients because of increased morbidity and mortality. This study identified risk factors for post-heart transplantation mortality in obese patients with a left ventricular assist device (LVAD).
METHODS: The United Network for Organ Sharing database was used to identify patients with a body mass index ≥35 kg/m2 who had a durable LVAD at the time of isolated heart transplantation between 2010 and 2021. The primary outcome was post-heart transplantation 1-year mortality. Multivariable Cox regression modeling was used to identify significant risk factors for 1-year mortality. Receiver-operating characteristic analyses were performed to identify optimal thresholds for continuous variables associated with the primary outcome. Patients were stratified by the number of risk factors, and Kaplan-Meier analysis was used to compare survival.
RESULTS: A total of 1222 obese patients were bridged to heart transplantation with a durable LVAD. Six risk factors were identified as significantly associated with 1-year post-heart transplantation mortality: recipient age >62.5 years, body mass index >36.6 kg/m2, bilirubin level >0.95 mg/dL, cold ischemic time >3.7 hours, recipient-donor sex mismatch, and pretransplantation mechanical ventilation. The distribution of cumulative risk factors was as follows: 8.6% with 0, 30.6% with 1, 37.0% with 2, and 23.8% patients with ≥3 risk factors. The 1-year survival rate decreased significantly from 96.0% in those patients with 0 risk factors to 77.6% in those with 3 or more risk factors.
CONCLUSIONS: These data provide a useful guide for risk stratification and patient selection in obese LVAD candidates being considered for heart transplantation.
BACKGROUND: A significant rise in childhood obesity worldwide over the past three decades highlights the urgent need for early interventions, especially in preschools as key settings for child development. This study aimed to assess the feasibility and fidelity of a randomised controlled trial of "I'm an Active Hero" (IAAH), a theory- and evidence-based multi-component behaviour change intervention targeting physical activity and sedentary behaviour amongst preschool-aged children.
METHODS: Two preschools in Taif city, Saudi Arabia were randomly assigned to either the intervention (n = 3 classrooms) or the usual curriculum control group (n = 3 classrooms). The intervention ran for 10 weeks from February to April 2023 and consisted of teacher-led physical activity and sedentary behaviour sessions in preschools, with an additional interactive home component. Primary outcome measures included intervention fidelity, recruitment rates, attrition rates, and compliance with trial procedures. Secondary outcomes included body mass index (BMI), objectively measured physical activity, and sedentary time via the ActiGraph GT3X accelerometer. Outcomes were measured at baseline and at 10 weeks in both study arms.
RESULTS: The preschool intervention component had high fidelity (93.3%), but the home component fidelity was lower (74%). A cluster-level recruitment rate of 12% (13/112 centres) was attained, whilst the individual-level recruitment rate stood at 36% (52/143 children, mean age of 4.16 years; 23 girls). Attrition was 10%. Compliance varied with 90% for BMI, 71% for accelerometery, and 45% for questionnaires. The intervention group showed small decreases in BMI, slight increases in physical activity, and decreases in sedentary time at follow-up compared to the control group. Parents, facilitators, and assistant teachers considered the intervention to be feasible and beneficial.
CONCLUSION: The IAAH intervention was feasible to implement in Saudi Arabian preschools. Facilitators showed high fidelity in delivering it. However, preliminary data did not demonstrate effectiveness. A more comprehensive evaluation across a broader population is warranted. The intervention could be revised to optimise recruitment, compliance, and fidelity of the home-based component. Successful elements from this pilot should be retained whilst adaptations to implementation are made to strengthen key areas.Clinical trial registration: ClinicalTrials.gov, NCT05754359.
Study design was randomized single blinded. Total of 126 geriatric subjects from March-April 2021 were allocated into survival thermal blanket group (n=63) dan draping fabric group (n=63). Preinduction temperature was measured using timpanic membrane termometer. Intraoperatively, temperature is measured using nasopharynx.Study design was randomized single blinded. Total of 126 geriatric subjects from March-April 2021 were allocated into survival thermal blanket group (n=63) dan draping fabric group (n=63). Preinduction temperature was measured using timpanic membrane termometer. Intraoperatively, temperature is measured using nasopharynx.