anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to a hospital bed automation system that collects vital signs and other parameters of a patient, being captured from a plurality of sensors, medical equipment and devices installed at the rim of the bed, the patient and the internalization environment. The system further has microprocessors installed at the inlet of the bed and the bed of the patient for capturing the signals that are transmitted to a central server with database for recording said data from each patient after a step of reading and correlating the signals for processing the data in real time. An application server performs the interface between the database, a system for managing medical information and local and remote users accessing information. The system is established by wired and wireless communication networks by Ethernet or Serial RS232 standard, RS422 and RS485, Wifi, cellular, digital or infrared. Methods for performing read and correlation of signals for real-time data processing are performed by computer programs embedded in microprocessors. It has technical operability with varying equipment or systems and can be employed on medical centers, hospitals and home medical treatment.
Participants will receive 25 milligram (mg) to 50 mg of RLAI intramuscularly (into the muscle) which will be tapered and discontinued over a period of up to 6 weeks. Participants will be followed-up until their first disease relapse or maximum of 36 months.
The subject was asked to contract the ADM muscle as hard as possible in isometric conditions for 10 seconds. CMAP's was recorded 2 seconds after the end of the exercise and then every 10 seconds for 50 seconds.
FIELD: medicine; dentistry.SUBSTANCE: invention relates to medicine, dentistry, microbiology. Used to prevent dental caries in young children. Achieved by the implementation of the main and additional programs of prevention. Main program includes counseling and educational work with parents. Additional program uses gel applications with colloidal silver Ag + 30 ppm according to the scheme for 6 months in the S. mutans source biotopes on the lingual surfaces of the lower jaw teeth and the back of the tongue mucosa 1–2 times a day on an empty stomach. Use natural non-carbonated mineralized oxygen water 2 times a day. Use freshly squeezed carrot juice, or carrot puree, or ready-made carrot puree "FrutoNyanya" 2 times a day. Apply dental floss. Water “Wave of Baikal” with a neutral pH and bioavailable ions of calcium, magnesium and silver in the morning on an empty stomach 20–30 minutes before meals and in the evening before going to bed according to the scheme before applying the gel with colloidal silver is used, at one time for children from 6 to 12 months – 20–30 ml each, from 1 to 2 years old – 30–40 ml each, from 2 to 3 years old – 40–50 ml each or for individual needs. Juice / puree is prepared from organic carrots, given within the age norm, 2 times a day with meals from 12.00 to 18.00 according to the regimen: children from 6 to 12 months – 20.0 ml / 1 tbsp. l.; from 1 to 2 years – 40.0 ml / 2 tbsp. l.; from 2 to 3 years – 40.0–60.0 ml / 2–3 tbsp. l. Basic course includes the use of carrot juice / puree for 7 days, 7 days break, just 3 months, alternating: 7 days natural water and colloidal silver, 7 days natural water and carrot juice / puree; supporting course of 3 months, drinking carrot juice / puree 1 time a day until 18.00, water 2 times a day, colloidal silver 1 time before going to bed 14 days, and 14 days break, dental floss is used waxed, bulky, once or twice a day before going to bed or after each meal, if it is possible.EFFECT: method provides for the management of factors: cariogenicity of dental plaque, the titer of cariogenic bacteria Streptococcus mutans, the cleansing properties of saliva, histadragous and coadhesive ability of the oral microbiome, dehydration of the oral tissues, stimulation of specific immunity.1 cl, 20 dwg, 5 ex, 3 tbl
OBJECTIVE: As pediatric mortality improves, approaches to pediatric critical care now focus on understanding long-term implications of survivorship on patients and families. We aimed to characterize how patients recall time spent sedated and recovering to identify areas for improvement in patient outcomes.
METHODS: We undertook qualitative analysis using semistructured interviews of pediatric patients requiring extra-corporeal support in our intensive care units from 2018 to 2023. All patients were English-speaking, >12 years old at time of hospitalization, and able to communicate at an age-appropriate level. Priority sampling was given to those with more recent hospitalizations to improve recall. Interviews were recorded and transcribed before thematic, inductive analysis.
RESULTS: Forty-one patients met inclusion criteria; 14 patients were enrolled before achieving thematic saturation. Several themes emerged, centering on cognitive, physical, and socioemotional experiences during and after hospitalization. Notable findings include profound awareness under sedation, impaired sleep, challenges with communication, physical discomfort, frustration with activities of daily living limitations, and gratitude for provider and family presence. Postdischarge, patients highlighted persistent memory, concentration, sleep, and physical impairments, as well as emotional processing of their illness and mortality.
CONCLUSIONS: Our findings describe how pediatric critical illness impacts short and long term cognitive, physical, and socioemotional outcomes for children in the ICU. Future research is necessary to study if there are specific, modifiable factors in patients' care that impacts their experience of critical illness, such as specific medication choices, diagnoses, communication styles, or physical and speech therapy interventions.
U.S. military service members engaged in alcohol misuse are a vulnerable population with high unmet need. Alcohol misuse is a stage of problem drinking that occurs before abuse and dependence, placing service members' partners and families at risk for serious consequences. Unfortunately, existing military reporting policies may discourage service members from seeking help for fear of negative career consequences. Service members report encouragement from their partners as the most prevalent facilitator of seeking care and individuals who change their drinking patterns most often cite partner support as the most helpful mechanism in supporting change. Thus, targeting service members' partners using preventive interventions can be an important vehicle for preventing the progression to abuse and dependence. A 3-year study is proposed to adapt and pilot-test a web-based intervention (WBI) intended to help concerned partners (CPs) provide support to service members with alcohol misuse and to begin development of a service member module based on service member's input. First, an evidence-based intervention known as Community Reinforcement and Family Training (CRAFT) intervention will be adapted to the web. The specific aims are as follows: Aim 1: Develop a 4-session web-based intervention (WBI) prototype and make iterative revisions based on feedback from 15-20 CPs. Aim 2: Conduct a randomized controlled pilot-test of the finalized WBI (n=50) compared to delayed WBI (n=50), and evaluate the impact of the WBI on CP's reports of service member help-seeking (e.g., counseling, self-help, primary care, treatment) and drinking, and CP well-being and relationship satisfaction three months after the intervention. Aim 3: Begin development of a follow-on WBI module for service members based on service member input and content evaluation. Service members will be asked their intervention preferences and feedback on a proposed WBI for them. This project is significant because it has the potential to benefit a large population of military service members who may be disproportionately affected by the current OEF/OIF/OND conflicts and whose drinking misuse would otherwise go undetected and untreated. It also develops a new prevention model that does not rely on service members or partners attending a hospital or clinical facility to access care. The proposed study is innovative because there are no CP-based preventive interventions addressing misuse. This pilot study will inform the development of an R01 trial that evaluates a larger randomized study of a WBI for CPs with a follow-on intervention for service members.
Carbon ion radiotherapy (CIRT) has received attention for the treatment of locally recurrent rectal cancer. When the surrounding primary organs are close to the irradiation site, a spacer is required to ensure safe irradiation. This work describes a novel technique using a bioabsorbable polyglycolic acid spacer placed laparoscopically and presents a technical report with five case studies. The short-term surgical outcomes were as follows: mean operating time 235 min with blood loss of 38 mL. CIRT was planned, and the patients underwent irradiation within 2 months of surgery. No pelvic infections occurred, and all procedures were performed safely. Herein, were present a technical report with reference to a video of the surgical procedure.
PURPOSE: To obtain a plaster having a proper expanding action, capable of well corresponding to the unevenness of a diseased part and being adhered to the diseased part without forming creases, good in waterproofness, and capable of well protecting the diseased site. CONSTITUTION: An adhesive layer 3 is placed on one side of a nonwoven fabric 1 formed from elastic fibers such as polyurethane fibers. The nonwoven fabric is impregnated with an acrylic synthetic resin 2 having adhesivity to the elastic fibers. The impregnation amount of the acrylic synthetic resin is approximately 1/5 to 1/2 of the basis weight of the nonwoven fabric. The nonwoven fabric subjected to the impregnation treatment is further adhered to a water-repelling agent to perform a water-repelling treatment. A pad 7 may be fixed to the adhesive layer.
PROBLEM TO BE SOLVED: To obtain a toxin shock preventing and treating agent by using a specific vitamin having extremely high safety as an active ingredient. SOLUTION: This preventing and treating agent is obtained by using vitamin B2 , especially rivoflavin, rivoflavin sodium phosphate, flavin mononucleotide, flavin mononucleotide or flavin adeninedinucleotide. Toxin is preferably a toxin derived from bacterium, especially preferably endotoxin or enterotoxin. The toxin shock preventing and treating agent can be prepared in a form of injection, tablets, granules, powder, capsules. It is necessary to formulate rivofravin in a form of injection by using a solubilizer of nicolic acid amide, etc., a synthetic surfactant or lecithin because of being slightly soluble in water in order to prepare rivoflavin among vitamin B2 as injection. Excess production of tumor necrosis factor in serum produced after administering toxin is suppressed by administration of vitamin B2 .
This is a single-arm non-randomized single institution phase 2 trial, designed to evaluate the therapeutic activity of CMVpp65-CTLs generated from seropositive HSCT donors when adoptively transferred into transplant recipients with persistent CMV infection or viremia. Patients eligible for this trial will be consenting recipients of related or unrelated HSCT who have an active CMV infection or persistent CMV viremia for ≥ 2 weeks despite treatment with anti-viral agents or who cannot be maintained on anti-viral therapy due to treatment related toxicity.
BACKGROUND: Menstruation is a physical symptom that occurs in women of reproductive age. It has a significant impact on the daily life and health of women when their academic and social activities are most active. Since many women experience difficulties in daily life because of premenstrual syndrome and dysmenorrhea, it is important to identify, prepare for, and manage the menstrual cycle in advance.
OBJECTIVE: This study aimed to investigate the relationship between menstruation-related experiences and the use of mobile-based period tracker apps by millennial and generation Z (gen Z) individuals. The objectives of this study are to investigate (1) menstrual cycle management, (2) factors affecting app usage (3) factors affecting cycle management, and (4) motivators and barriers to using period tracker apps, in millennial and gen Z women.
METHODS: A mixed methods design was used for this study. The participants were young women aged 20-39 years and recruited via the Ovey application. Data were collected through surveys and focus group interviews. The survey was conducted among 700 women, and 8 of them participated in the focus group interviews.
RESULTS: In total, 431 (62.3%) participants used period tracker apps primarily to predict their next menstrual cycle. Factors affecting app usage included childbirth experience (odds ratio [OR] 0.475, P<.05), number of dysmenorrhea symptoms (OR 1.136, P<.05), and cycle management level (OR 2.279, P<.001). Additionally, education level (OR 1.122, P<.05 [university level compared high school level]) and the number of dysmenorrhea symptoms (OR 1.024, P<.05) showed a positive association with the cycle management level. However, childbirth experience (OR 0.902, P<.05) and period irregularity (OR 0.929, P<.001) were negatively associated with the cycle management level.
CONCLUSIONS: Period tracker apps are becoming the new normal among millennials and gen Z individuals for managing their menstrual cycles. The use of a period tracker app empowers women by helping them gain a better understanding of their bodies, ultimately enhancing their social, academic, and health-related lives. Improving the accuracy and literacy of the app is an ongoing task for period-tracking apps, and it is important to provide added value tailored to users' needs. Therefore, the findings of this study should be considered when designing or upgrading period tracker apps to facilitate the adoption of digital technology among young women, thereby promoting their overall well-being and reproductive health.
Children with hemiplegic cerebral palsy were assessed by Manual Muscle Testing (MMT) to determine the muscle power/strength, Goniometer to determine the Range of Motion (ROM), Disability of Arms, Shoulders, and Hand (DASH) questionnaire to assess the function of upper extremity, and Pediatric Balance Scale to determine the body balance and were assigned in the Bubble Pop group. Each subject in second group would complete 8 weeks of augmented reality(AR) therapy sessions which would be aimed to improve the muscle power/strength, range of motion, balance and function. . Each subject would be evaluated before their first AR therapy session (pre- interventionally) and after their last AR therapy session (post-interventionally) for changes in muscle power, ROM, upper extremity function and balance.
Disclosed is an apparatus for manufacturing a mask pack containing gel. According to an embodiment of the present invention, the apparatus (100) for manufacturing a mask pack containing gel comprises a film supply unit (110), a film stacking unit (120), a drying unit (140), and an accommodation storage unit (150). The film supply unit (110) includes a first protection film supply roller (111), a gel film supply roller (113) and a second protection film supply roller (112) which are vertically arranged on the ground. The film stacking unit (120) includes a gel supply unit which supplies gel (104) between films while stacking the films. The accommodation storage unit (150) includes a tension maintenance device (160) for maintaining a predetermined tension by measuring the tension of the film supplied from the film supply unit (110) in real time. According to the present invention, the apparatus for manufacturing a mask pack containing gel is able to: shrink a space occupied by a manufacturing line; efficiently maintain a manufacturing process; manufacture a high quality mask pack containing gel; manufacture products having uniform quality even when a worker is changed; and reduce manufacturing costs.
PROBLEM TO BE SOLVED: To provide isoxazoline-5-carboxamide compounds or salts thereof, which are excellent in acaricidal activity and/or insecticidal activity, are excellent in safety, and can be synthesized industrially advantageously.SOLUTION: Provided are isoxazoline-5-carboxamide compounds represented by formula (II), etc. or salts thereof, and a pest control agent, an acaricide, or an insecticide containing at least one selected from the compounds. In the formula (II), Cy represents a pyridyl group unsubstituted or having 1 to 4 substituent groups X, etc.; the substituent group X represents a halogeno group, unsubstituted or substituted alkyl group, etc.; R, R, and Reach independently represent an unsubstituted or substituted alkyl group, etc.; and Rrepresents an unsubstituted or substituted alkyl group, or an unsubstituted or substituted pyridyl group, etc.SELECTED DRAWING: None
Despite recent advance in understanding the biology of the amyloidogenic clone and despite the availability of different therapeutic options, there are still patients who fail to respond to fist line therapy and experience relapse after response to first line regimens. The toxicity profile of daratumumab resulted favorable in the setting of advanced AL amyloidosis patients with severe organ damage. Pomalidomide has proven to be effective as a single agent in R/R AL amyloidosis with a better safety profile over lenalidomide because of relevant renal toxicity of the latter drug in presence of nephrotic proteinuria. Daratumumab is a recently released mAb that has shown deep hematological responses in R/R multiple myeloma with a favorable toxicity. Up-to-date clinical data have further demonstrated the high efficacy of combination regimens including an ImiD/Daratumumab combination in R/R multiple myeloma reaching unprecedented results in terms of response rate, progression free survival (PFS) and minimal residual disease (MRD) negativity.

On these bases, the present study aims to explore the doublet Daratumumab/pomalidomide in R/R AL amyloidosis. The goal of the study is to obtain rapid, durable and deep hematological responses with a low toxicity profile. The expectation is to attain a very favorable benefit/risk ratio from this combination as these patients should experience a low rate of treatment discontinuation, hospitalization due AEs and/or disease progression and/or organ failures.
It is well known that some components of the diet could promote the growth of certain bacterial strains present in the intestine, which are closely associated with benefits for host health. In the previous study, the investigators found that an intestinal commensal Parabacteroides goldsteinii (Pg) was highlighted to be significantly negatively associated with severity of COPD. Furthermore, the investigators identify the potential prebiotics (PHGG) which may enrich the abundance of P. goldsteinii and increase the probiotic effect of P. goldsteinii. However, the effect of PHGG supplement on compositional and functional properties of the human microbiota with COPD still remains unclear.

In this proposal, the investigators designed a randomized control study, which enroll adults diagnosed with COPD. The investigators will review their past medical records and related image and lung function test. Then the two groups will receive PHGG or not. Stool samples will be collected. The ameliorative efficacy will be evaluated by questionnaire and lung function test. Intestinal microbiota and metabolome will be analyzed and the correlation with lung function indices will be further investigated. In the future, it may be used to investigate and analyze the change of microbiota and metabolome, then develop possible treatment options of COPD.
The participants will see fruit drinks with the nutrition claim "100% All Natural" (task 1). They will see a snack with a barcode label (control label) (task 2).
BACKGROUND: Chronic hepatitis B (CHB) virus is the most common risk factor for developing liver malignancy. Autophagy is an essential element in human cell maintenance. Several studies have demonstrated that autophagy plays a vital role in liver cancer at different stages. In this systematic review, we intend to investigate the role of polymorphism and mutations of autophagy-related genes (ATGs) in the pathogenesis and carcinogenesis of the hepatitis B virus (HBV).
MATERIALS AND METHODS: The search was conducted in online databases (Web of Science, PubMed, and Scopus) using Viruses, Infections, Polymorphism, Autophagy, and ATG. The study was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria.
RESULTS: The primary search results led to 422 studies. By screening and eligibility evaluation, only four studies were relevant. The most important polymorphisms in hepatocellular carcinoma were rs2241880 in ATG16L1, rs77859116, rs510432, and rs548234 in ATG5. Furthermore, some polymorphisms are associated with an increased risk of HBV infection including, rs2241880 in ATG16L1 and rs6568431 in ATG5.
CONCLUSION: The current study highlights the importance of rs2241880 in ATG16L1 and rs77859116, rs510432, and rs548234 in ATG5 for HBV-induced HCC. Additionally, some mutations in ATG16L1 and ATG5 were important in risk of HBV infection. The study highlights the gap of knowledge in the field of ATG polymorphisms in HBV infection and HBV-induced HCC.
PROBLEM TO BE SOLVED: To obtain an activity accelerator having phosphatidyl choline sterol acyl transferase activity accelerating action and suitable for curing and prevention of hyperlipemia disease. SOLUTION: This accelerator is composed of essence of a plant belonging to genus Ligustrum in family Oleaceae (preferably Ligustrum pedoncrale or Ligustrum pulpurasence). The essence is preferably an extract from a polar solvent or its distilled out substance from the solvent. A using position in the used plant is preferably a leaf part. An optimum one in the essence is obtained by extracting a leaf part with hot water, adsorbing to a suitable carrier, eluting with ethanol and condensing under a reduced pressure. A suitable administration dose of the essence is 5-500mg for an adult per 1 day in dividing to several times in a case of oral administration and 1-100mg in a case of an injection.
Insufficiently active adults with obesity assigned to the attention control group. At the end of the 6-month study period, participants will receive access to the PATH program, with out the coaching component.
Sotalol AF are indicated for the maintenance of normal sinus rhythm [delay in time to recurrence of atrial fibrillation/atrial flutter (AFIB/AFL)] in patients with symptomatic AFIB/AFL who are currently in sinus rhythm. Because Sotalol AF can cause life-threatening ventricular arrhythmias, it should be reserved for patients in whom AFIB/AFL is highly symptomatic. Patients with paroxysmal AFIB whose AFIB/AFL that is easily reversed (by Valsalva maneuver, for example) should usually not be given Sotalol AF (see WARNINGS). 

In general, antiarrhythmic therapy for AFIB/AFL aims to prolong the time in normal sinus rhythm. Recurrence is expected in some patients (see Clinical Studies). 

Sotalol is also indicated for the treatment of documented life-threatening ventricular arrhythmias and is marketed under the brand name Betapace® (sotalol hydrochloride). Sotalol hydrochloride tablets, however, must not be substituted for sotalol hydrochloride tablets (AF) because of significant differences in labeling (i.e., patient package insert, dosing administration and safety information).