anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In the United States in 2014, nearly 2.9 million individuals sustained traumatic brain injuries that resulted in emergency department visits, hospitalizations, and death. Traumatic brain injury (TBI) is caused by trauma, or an external force that creates rapid acceleration and deceleration of the brain within the skull creating lasting neurophysiological dysfunction. Although there are many effective treatment strategies for the weeks and months post-injury (e.g. intensive, multi-disciplinary in-patient rehabilitation), millions of individuals are living with residual disability from brain injury following discharge to home. This residual disability can include significant social, cognitive, emotional, and physical impairment. To date, there are limited strategies for treating the residual deficits of chronic brain injury. One such physical deficit is balance impairment, which is associated with increased fall risk, reduced community integration, and decreased quality of life. The use of intensive, holistic rehabilitation may be effective for improving balance and other impairments in individuals with chronic brain injury. Yoga, a holistic treatment option, is thought to be more therapeutic than traditional exercise because of the integration of the mind, body, and spirit. Further, yoga can be modified to accommodate individual abilities and needs. And, unlike formal rehabilitation, yoga does not need to be approved by insurance or prescribed by a physician and adapted yoga is available in the community. Thus, yoga is readily available, so long as yoga instructors are trained to appropriately modify activities. Recently, the research team found that group yoga improved balance performance in seven adults with chronic brain injury. This study is designed to test the feasibility of conducting another group yoga intervention and acquiring neuroimaging data before and after the intervention.
The primary end point by which the sample size was determined was a total operative time \<5hr. In the last 50 cases of our series (data unpublished) this benchmark was obtained in 60% of patients (p0), while we expect to improve the time efficiency of the procedure with the use of robotic staplers maintaining the total operative time of the procedure \<5hrs in at least 80% (p1) of cases. According to A'Hern, in order to verify the significance of this hypothesis, the estimated sample size is 33 patients with a power of 80% at a significance level of 5%. The trial will be successful if the total operative time will be \<5hrs in at least 25 out of 33 patients.

The population of this study will include 35 patients with muscle invasive bladder cancer without contraindications to orthotopic neobladder. The first two cases will be excluded in order to provide the entire surgical team the minimal skill necessary for a proper and time efficient use of the new surgical device (robotic stapler). The following 33 consecutive cases will be enrolled and the outcomes analyzed. The estimated time to complete the enrollment is 9 months.
Along with the increasing prevalence of obesity worldwide, the deleterious effects of high-calorie diet are gradually recognized through more and more epidemiological studies. However, the concealed and chronic causality whitewashes its unhealthy character. Given an ingenious mechanism orchestrates the metabolic adaptation to high-fat high-fructose (HFF) diet and connive its lipotoxicity, in this study, an experimental rat/mouse model of obesity was induced and a comparative transcriptomic analysis was performed to probe the mystery. Our results demonstrated that HFF diet consumption altered the transcriptomic pattern as well as different high-calorie diet fed rat/mouse manifested distinct hepatic transcriptome. Validation with RT-qPCR and Western blotting confirmed that SREBP1-FASN involved in de novo lipogenesis partly mediated metabolic self-adaption. Moreover, hepatic ACSL1-CPT1A-CPT2 pathway involved in fatty acids β-oxidation, played a key role in the metabolic adaption to HFF. Collectively, our findings enrich the knowledge of the chronic adaptation mechanisms and also shed light on future investigations. Meanwhile, our results also suggest that efforts to restore the fatty acids metabolic fate could be a promising avenue to fight against obesity and associated steatosis and insulin resistance challenged by HFF diet.
Pyriproxyfen is a pesticide used in Brazil to control the Aedes aegypti mosquito, vector of arboviruses like Zika and dengue. However, this pesticide is structurally similar to retinoic acid, a metabolite of vitamin A that regulates neuronal differentiation and hindbrain development during the embryonic period. Due to the similarity between pyriproxyfen and retinoic acid, studies indicate that this pesticide may have cross-reactivity with retinoid receptors. Thus, pregnant exposure to pyriproxyfen could interfere in the nervous system development of the fetal. In this context, the present study evaluated whether prenatal exposure to pyriproxyfen affects neonatal development and brain structure in rats. Wistar rat pups were divided in three experimental groups: (1) negative control (CT-)-offspring of rats that drink potable water during pregnancy; (2) pyriproxyfen (PIR)-offspring of rats exposed to Sumilarv® prenatally, a pesticide that has pyriproxyfen as active ingredient; and (3) positive control (CT+)-offspring of rats exposed to an excess of vitamin A prenatally. Only vitamin A treated-pregnant showed lower weight gain, but gestation length was similar among pregnant that received potable water, water containing vitamin A and water containing Sumilarv. In relation to the offspring, PIR group exhibits a delayed front-limb suspension response but performed early the negative geotaxis reflex. On the other hand, CT+ group exhibited lower body weight in the 1st postnatal day, delayed audio startle response, but performed early the eyelids opening and hindlimb placing response. A reduction in the maximum brain width was observed both in PIR and CT+ groups, but a reduction in the number of neurons in the M1 cortex was showed only in CT+ group. The number of glial cells in this brain area was similar between the three experimental groups studied. Although prenatal exposure to pyriproxyfen did not alter neonatal milestones in the same way as vitamin A in excess, both substances caused a reduction in the maximum width of the brain, suggesting that this pesticide can produce neurotoxic effects during the embryonic period.
BACKGROUND: Myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease (MOGAD) is an autoinflammatory disease of the central nervous system. MOGAD often follows a relapsing course that can lead to severe disability, but monophasic disease is possible as well. Currently, there is an unmet clinical need for disease activity biomarkers in MOGAD. Serum neurofilament light chain (sNfL) is a sensitive biomarker for neuroaxonal damage. However, data on longitudinal change of sNfL as disease activity biomarker for MOGAD are scarce.
OBJECTIVE: To describe the longitudinal course of sNfL in adult patients with MOGAD in an active as well as a stable disease state in relation to clinical parameters and serum MOG-IgG titers.
METHODS: We conducted a retrospective, exploratory, monocentric cohort study of adult patients with MOGAD. Cohort 1 consisted of five patients in whom NfL was tested as part of their routine clinical workup, all of which had active disease (maximum 6 months since last attack, median 3 months). Cohort 2 comprised 13 patients, which were tested for NfL in the context of a longitudinal study at predefined time intervals, mostly during remission (median 10 months since last attack). sNfL was measured using single molecule array (Simoa) technology at least at two time points (median 3) within a median observation time of 5 months in cohort 1, and at baseline and after a median duration of 12 months in cohort 2. MOG-IgG titers were measured by a fixed cell-based assay.
RESULTS: Change in sNfL correlated positively with change in MOG-IgG titers (rho=0.59, p = 0.027). The variability of sNfL (difference between highest and lowest level) during the observation period was higher in patients who had an attack within six months before baseline (median 37 [interquartile range [IQR] 10-64] pg/ml vs. 2.3 [IQR 1-5] pg/ml, p = 0.006). sNfL increased in patients with an attack during the observation period. Patients with baseline sNfL measurement within two weeks after attack symptom onset displayed relatively low initial sNfL with an increase afterwards.
CONCLUSIONS: Longitudinal sNfL change correlates with MOG-IgG titer change and may be a promising biomarker candidate for disease activity in MOGAD. Increasing sNfL levels might be utilized to adjudicate suspected attacks. In acute attacks, sNfL increase may occur with a delay after symptom onset.
Chemotherapy has markedly improved cancer outcomes, yet cancer therapy-related cardiac dysfunction (CTRCD) poses a significant challenge, affecting around 10% of patients. CTRCD can be asymptomatic or present with heart failure symptoms. Multimodality imaging, particularly echocardiography, remains pivotal for monitoring cardiac function. Potential biomarkers for CTRCD assessment include troponin and B-type natriuretic peptide. Pharmacological interventions, such as dexrazoxane, angiotensin-converting enzyme inhibitors, and statins, play a crucial role in primary prevention and mitigating cardiotoxicity alongside cardiac rehabilitation programs. Thus, a comprehensive approach is essential for optimal cardiac recovery and improved patient outcomes.
The invention discloses a traditional Chinese medicine composition for treating swine eperythrozoonosis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 12-19 parts of leaves of umbrella sedge, 5-12 parts of roots of sarcococca ruscifolia staptvar. Chinen sis (Franch) Rehd.Et.Wils, 25-33 parts of roots and root bark of securidaca inappendiculata Hassk., and 15-23 parts of stem bark of berberis dasystachya. The preparation method comprises the steps that leaves of umbrella sedge and roots of sarcococca ruscifolia staptvar. Chinen sis (Franch) Rehd.Et.Wils are smashed, and stirring and drying by evaporation, grinding and screening are performed by adding absolute ethyl alcohol to obtain a mixture A; roots and root bark of securidaca inappendiculata Hassk. and stem bark of berberis dasystachya are smashed, baked and subjected to SC-CO2 extraction for two times, and extracting solutions are merged to prepare a mixed solution B; the mixture A and the mixed solution B are mixed, high-temperature and high-pressure stirring and drying are performed, and then the traditional Chinese medicine composition is obtained. The traditional Chinese medicine composition is wide in material source, low in cost, safe, effective, free of medicine resistance and convenient to use, is used for treating the swine eperythrozoonosis and has the effects of killing parasites and removing qi stagnation, clearing heat and removing toxicity, strengthening vital qi to eliminate pathogenic factors, stopping bleeding and cooling the blood, benefiting qi and nourishing the blood, harmonizing the stomach and strengthening the spleen and enhancing the organism immunity, the cure rate is high, the swine eperythrozoonosis does not relapse after being cured, no toxic or side effect exists, and the cost is low.
To provide a nano-helix-substrate complex for regulating the attachment and polarization of macrophages and a method for producing the same, and to provide a method for regulating the attachment and polarization of macrophages using the complex.SOLUTION: Provided is a nano-helix-substrate complex for regulating the attachment and polarization of macrophages, the complex comprising a substrate, a nano-helix chemically bonded to the substrate, and an integrin ligand peptide chemically bonded to the nano-helix. The nano-helix is composed of a helix nanowire and comprises one or more metal elements. The nano-helix has a length of 100 nm to 20 μm, and includes a reversible length change of within the range of the following equation 1 depending on the presence or absence of application of a magnetic field. [Equation 1] |L1-L0|>10 nm. In the equation 1, L1 is a length of a nano-coil when a magnetic field is applied, and L0 is a length of the nano-helix to which no magnetic field is applied. The method for regulating the attachment and polarization of macrophages is to regulate the attachment and polarization of macrophages by controlling the presence or absence of application of a magnetic field to the complex.SELECTED DRAWING: Figure 1
On 22 March 2023, the FDA approved rezafungin (Rezzayo) for the treatment of candidemia and invasive candidiasis in adults with limited or no alternative treatment options. Rezafungin is an echinocandin that supports weekly dosing, enabling outpatient parenteral treatment that potentially avoids the need for a central venous catheter. Approval of rezafungin was based on a single adequate and well-controlled phase 3 study designed with a day 30 all-cause mortality primary end point and 20% noninferiority margin, which demonstrated that rezafungin is noninferior to the comparator echinocandin. Nonclinical studies of rezafungin in nonhuman primates identified a neurotoxicity safety signal; however, rezafungin's safety profile in the completed clinical studies was similar to other Food and Drug Administration-approved echinocandins. Here we describe the rationale for this approval and important considerations during the review process for a flexible development program intended to expedite the availability of antimicrobial therapies to treat serious infections in patients with limited treatment options. Clinical Trials Registration . NCT02734862 and NCT03667690.
Patients in this group will receive Breast MRI and annual mammography. Participants will complete 4 questionnaires at 3 time points: enrollment; 2 weeks after they receive their mammogram; 6 months after their mammogram. The intervention is the addition of the FAST Breast MRI.
PURPOSE:An antitumor agent, containing a novel lymphotoxin and human interferon-gamma and having more remarkably improved antitumor activity than a composite pharmaceutical containing lymphotoxin derived from lymphoblastic cells and interferon-gamma. CONSTITUTION:An antitumor agent containing a novel human lymphotoxin expressed by the formula (X is Met, H, etc.; Y is saccharide chain or H) and human interferon-gamma, preferably at 20:1-1:20 compounding ratio. The lymphotoxin expressed by the formula is a new type different from an amino acid sequence of lymphotoxin derived from lymphoblastic cells, e.g. reported by Gray, etc. The antitumor activity is remarkably higher than a conventional agent and the agent is capable of exhibiting synergistic effect with the interferon-gamma. The titled antitumor agent is applicable to malignant tumors, e.g. mammary cancer, lung cancer, gastric cancer, etc.
Microplastic particles (MPs) have been detected in a variety of environmental samples, including soil, water, food, and air. Cellular studies and animal exposures reported that exposure to MPs composed of different polymers might result in adverse effects at the portal of entry (local) or throughout the body (systemic). The most relevant routes of particle uptake into the body are oral and respiratory exposure. This review describes the various processes that may contribute to the adverse effects of MPs. Only MPs up to 5 µm were found to cross epithelial barriers to a significant extent. However, MPs may also exert a detrimental impact on human health by acting at the epithelial barrier and within the lumen of the orogastrointestinal and respiratory tract. The potential for adverse effects on human health resulting from the leaching, sorption, and desorption of chemicals, as well as the impact of MPs on nutritional status and dysbiosis, are reviewed. In vitro models are suggested as a means of (1) assessing permeation, (2) determining adverse effects on cells of the epithelial barrier, (3) examining influence of digestive fluids on leaching, desorption, and particle properties, and (4) role of microbiota-epithelial cell interactions. The contribution of these mechanisms to human health depends upon exposure levels, which unfortunately have been estimated very differently.
As one of the core components of multidisciplinary CR, psychiatrist and psychologist consultation was delivered to all patients. Cognitive function was assessed with the Luria-Nebraska Neuropsychological Battery-Screening test (LNNB-S) Chinese version by an experienced psychologist. The evaluation would be completed during admission. The initial LNNB was condensed to fifteen items for the screen test by Golden. LNNB-S Chinese version focuses on 3 domains, including number calculation, cognitive function, and rhythm control. In our participants' cohort, investigators choose LNNB-S \>=10 as a cutoff point. That is, participants may have cognitive impairment when their LNNB-S \>=10.
The invention provides toothpaste containing an extractive of Chinese caterpillar fungus and a machining method thereof. The technical problems that the conventional toothpaste mostly consists of chemical anti-microbial components and has high insecurity risk can be solved. The toothpaste containing the extractive of the Chinese caterpillar fungus provided by the invention is characterized in that a toothpaste recipe comprises lysozyme, the extractive of the Chinese caterpillar fungus, an abradant and a glycerol mixture. The machining process of the toothpaste containing the extractive of the Chinese caterpillar fungus provided by the invention has the following steps of: alloying the toothpaste abradant with the extractive of the Chinese caterpillar fungus; heating the blend inside vacuum drying equipment and drying for 20-40 minutes; and placing the dried blend of the dried abradant with the extractive of the Chinese caterpillar fungus into ball milling equipment for grinding into 200-600 meshes, so as to form a component. The toothpaste provided by the invention uses a natural product as an effect component. The effect component rapidly takes effect by the machining method without influencing the activity and matching with the better mass percent of a raw material.
BACKGROUND: The 2021 Surviving Sepsis Campaign Guidelines recommend administration of antimicrobials within the first hour of recognition of sepsis. Over the last decade, several studies have demonstrated improved time-to-antibiotic administration and antibiotic appropriateness when a pharmacist was involved in the care of patients with sepsis. To our knowledge, no studies evaluating the appropriate use of antibiotics in sepsis driven entirely by an Emergency Medicine (EM) Clinical Pharmacist Practitioner (CPP) have been published. The purpose of this study is to evaluate the impact of an EM CPP-driven protocol on antimicrobial interventions in patients with sepsis in the emergency department (ED).
METHODS: This was a retrospective comparison of patients with sepsis for whom antimicrobials were ordered in the ED without pharmacist intervention to patients whose antimicrobials were ordered by an EM CPP via a sepsis consult to pharmacy. An EM CPP reviewed individual patient profiles for pertinent historical admissions, culture data, and allergy profiles to guide antimicrobial selection for the suspected source of infection and entered orders under their scope of practice with formal documentation in the electronic medical record (EMR). The primary objective of this study was to compare the rates of appropriate empiric antibiotic utilization in septic patients admitted from the ED pre- and post-protocol implementation. Secondary endpoints included the following, broadening of ED-initiated empiric antibiotics on hospital admission, time-to-antibiotic administration, in-hospital mortality, Rapid Emergency Medicine Score (REMS) association with in-hospital mortality, and hospital length of stay.
RESULTS: A total of 144 patients were included: 80 patients prescribed antibiotics without pharmacist intervention and 64 prescribed antibiotics by an EM CPP. Appropriate empiric antibiotic selection in the ED improved from 57.5% (46/80) to 86% (55/64) with EM CPP intervention (difference 28.5%; p < 0.01). Time-to-first antibiotic administration decreased by 64 min (p < 0.01). Administration of antibiotics within 60 min, broadening of antibiotics on admission, hospital length of stay, and in-hospital mortality did not significantly differ across groups.
CONCLUSIONS: In this small, single-center study, an EM Clinical Pharmacist Practitioner-driven protocol for patients with sepsis in the emergency department improved the rate of appropriate empiric antimicrobial selection and time-to-antibiotic administration.
Treatment 2 group used CGM for two weeks with an AI food camera, followed by diet education, without a repeat three months later. They had a final follow-up at the 6-month mark.
PROBLEM TO BE SOLVED: To obtain a curcuma longa extract having a slight dyeability by extracting a rhizome of Curcuma longa with a hydrocarbon-based solvent and to obtain a composition for an oral cavity by incorporating the resultant Curcuma longa extract into the composition. SOLUTION: This Curcuma longa extract is obtained by extracting a rhizome of Curcuma longa with 1-50wt. times, preferably 2-20wt. times of a hydrocarbon- based solvent (e.g. hexane or petroleum ether) at 0-200 deg.C, preferably from a room temperature to 80 deg.C for 10min-1 month, preferably 1-24hrs, and filtrating or condensing, as necessary. The composition for an oral cavity is obtained by incorporating 0.001-10wt.%, preferably 0.005-5wt.% of the resultant Curcuma longa extract as an active component. The composition for an oral cavity can be prepared to paste dentifrice, tooth powder, liquid-like dentifrice, liquid dentifrice, a mouth-washing agent, a gargle, gingiva massage cream, a troche, a candy and chewing gum, etc. By using the Curcuma longa extract having reduced dyeability, an excellent composition for an oral cavity without dyeing a toothbrush, etc., can be obtained.
In the group where the mother's voice will be listened to, it will be explained to the child's parents that the mother's voice will be used for pain relief in the research. In the study, the researcher will take a voice from the mother of each child admitted to intensive care and record it on a voice recorder. Measurements will be made by placing the voice recorder 50 cm closer to the child to listen to the mother's voice. The volume of the mother's voice will be adjusted to an average of 45 decibels. The speaker will be placed at the end of the foot, approximately 30 cm from the child's ear, five minutes before the procedure and will be played to the child during the procedure.
FIELD: microbiology, biotechnology, medicine. SUBSTANCE: invention relates to producing preparations used for brucellosis diagnosis. Vaccine strain Brucella abortus-19 is cultured on the solid nutrient medium, the grown culture is washed off with citrate buffer (pH 5.3-5.5) and bacterial cells are inactivated by heating. Then the suspension of inactivated bacteria is resuspended with 12% sodium chloride solution to final concentration 2 x 10 10  CFU/ml and dye methylene blue and preserving agent phenol are added. Obtained diagnosticum is used in serological agglutination reactions by Right and Heddlsone. EFFECT: decreased number of nonspecific serological reactions in brucellosis diagnosis, retained high sensitivity. 1 ex