anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Adherence to treatment is a primary determinant for the effectiveness of health care. Non-compliance may lead to therapeutic failure, make more difficult and complex the management of chronic diseases or cause death. The effectiveness of interventions on adherence has an important impact in the health of the population. Systemic lupus erythematosus (SLE) is an autoimmune disease with high proportion of hospital admissions and deaths and high cost of treatment. The prevalence of adherence in this group of patients in Brazil is very low (31.7%) and the drug treatment is complex. Our aim is to assess the effectiveness of Pharmaceutical Care in the adherence of drug treatment by SLE patients attended in a Rheumatology outpatient clinic in Rio de Janeiro, Brazil.

Randomized clinical trial (pragmatic trial), in which 120 adult patients with confirmed SLE diagnosis will be followed for 12 months, and randomized in two groups: the intervention group (attended by a pharmacist according to the Dader Method for Pharmaceutical Care), and the control group (attended by a non-pharmacist professional with counseling on hygiene/nutrition and reduction of risks in lupus therapy). The main outcome will be adherence to drug therapy and secondary outcomes the improvement of the medical condition and the quality of life of the patients.
INTRODUCTION: Sepsis is a major cause of morbidity and mortality worldwide. In the updated, 2016 Sepsis-3 criteria, sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, where organ dysfunction can be represented by an increase in the Sequential Organ Failure Assessment (SOFA) score of 2 points or more. We sought to apply the Sepsis-3 criteria to characterise the septic cohort in the Amsterdam University Medical Centres database (Amsterdam UMCdb).
METHODS: We examined adult intensive care unit (ICU) admissions in the Amsterdam UMCdb, which contains de-identified data for patients admitted to a mixed surgical-medical ICU at a tertiary academic medical centre in the Netherlands. We operationalised the Sepsis-3 criteria, defining organ dysfunction as an increase in the SOFA score of 2 points or more, while infection was defined as a new course of antibiotics or an escalation in antibiotic therapy, with at least one antibiotic given intravenously. Patients with sepsis were determined to be in septic shock if they additionally required the use of vasopressors and had a lactate level >2 mmol/L.
RESULTS: We identified 18,221 ICU admissions from 16,408 patients in our cohort. There were 6,312 unique sepsis episodes, of which 30.2% met the criteria for septic shock. A total of 4,911/6,312 sepsis (77.8%) episodes occurred on ICU admission. Forty-seven percent of emergency medical admissions and 36.7% of emergency surgical admissions were for sepsis. Overall, there was a 12.5% ICU mortality rate; patients with septic shock had a higher ICU mortality rate (38.4%) than those without shock (11.4%).
CONCLUSIONS: We successfully operationalised the Sepsis-3 criteria to the Amsterdam UMCdb, allowing the characterization and comparison of sepsis epidemiology across different centres.
A method for generating a treatment plan for a psychological disorder uses both static and dynamic content to customize the logical model of the treatment plan for a particular patient. A file containing static content is generated at a static layer of a computer program. The file uses a machine readable format to define the treatment plan. A logical model that the program uses to implement the treatment plan is generated at a data modeling layer based on the static content. Events based on responses from the patient that were elicited in response to the static content are generated at an application logic layer. Dynamic content is created using the events. The logical model is then modified based on the dynamic content. The treatment plan is presented to the patient by a visualization layer based on the modified logical model. Responses to the treatment plan are received from the patient.
The present invention involves the usage of certain hemorheological methylxanthine analogs having structure (I) where R1 is -(CH2)4COCH3, or -(CH2)4COH(CH3)2 and R2 is -CH3, -H or CH2OCH2CH3. These methylxanthine analogs may be used for treating a systemic fungal infection, for example candidiasis. Administration of the analogs, preferably by parenteral means, at least once and possibly on a multiple dosage schedule may be used to effectively ameliorate systemic fungal infections. The preferred therapeutically effective dosage for such treatment is between 1 mg and 100 mg per kg animal weight. A preferred analog for this treatment is when R1 is -(CH2)4COH(CH3)2 and R2 is -H. The above analogs may generally be used to treat an animal to inhibit developement of or to alleviate renal dysfunction manifested by reductions in renal blood flow and glomerular filtration rates with increased vascular resistance. This dysfunction may be independent or relate to the toxicity of other drugs such as cyclosporine or amphotericin B.
Carcinogenic potential of obeticholic acid was assessed in carcinogenicity studies of up to 2 years in duration in mice and rats. In mice, there were no drug-related neoplastic findings at doses up to 25 mg/kg/day obeticholic acid, a dose that produced systemic exposures approximately 12-times those in humans at the MRHD of 10 mg. In rats, obeticholic acid was administered at doses of 2, 7, and 20 mg/kg/day. At 20 mg/kg/day (approximately 12-times the human exposure at the MRHD), obeticholic acid caused an increase in the incidence of benign granulosa cell tumors in the ovaries and benign granular cell tumors in the cervix and vagina of female rats. There were no drug-related neoplastic findings in male rats. 

Obeticholic acid was not genotoxic in the Ames test, a human peripheral blood lymphocyte chromosomal aberration test, and a mouse micronucleus test. The glycine conjugate of obeticholic acid was also not genotoxic in an Ames test and human peripheral blood lymphocyte chromosome aberration test. The taurine conjugate of obeticholic acid was not genotoxic in an Ames test, and was negative in a human peripheral blood lymphocyte chromosomal aberration test in the presence of metabolic activation; the findings of the chromosomal aberration assay in the absence of metabolic activation were inconclusive.

Obeticholic acid, administered at oral doses of 5, 25, and 50 mg/kg/day to male rats for 28 days before mating and throughout the mating period, and to female rats from 14 days before mating through mating and until gestation day 7, did not alter male or female fertility or early embryonic development at any dose (the 50 mg/kg/day dose is approximately 13-times the human exposure at the MRHD).
In order to evaluate fatigue in primary Sjögren's syndrome patients, questionnaires such as FACIT Fatigue Scale, Sjögren's Syndrome EULAR Patient Reporting Index, Fatigue Severity Scale, Fatigue Multidimensional Assessment Scale and Short Form-36, which are also used in many disease groups, are used. Although the importance of the effect of fatigue on pSS patients has been demonstrated in studies, most of the fatigue assessment questionnaires used are not pSS specific. For this reason, Bowman et al. They developed the Fatigue and Discomfort Profile - Sikka Symptoms Scale (PROFAD-SSI) to assess multidimensional fatigue in patients with pSS, considering disease symptoms. PROFAD-SSI is scored from 0 to 7 on an 8-point Likert scale. The 19-item scale evaluates patients in 8 different dimensions: somatic fatigue, mental fatigue, arthralgia, vascular dysfunction, oral dryness, ocular dryness, cutaneous and vaginal dryness.
Prostate cancer (PCa) is one of the most common cancers affecting the health of men worldwide. Castration-resistant prostate cancer (CRPC), the advanced and refractory phase of prostate cancer, has multiple mechanisms of resistance to androgen deprivation therapy (ADT) such as AR mutations, aberrant androgen synthase, and abnormal expression of AR-related genes. Based on the research of the AR pathway, new drugs for the treatment of CRPC have been developed in clinical practice, such as Abiraterone and enzalutamide. However, many areas in this pathway are still worth exploring. In this study, single-cell sequencing analysis was utilized to scrutinize significant genes in the androgen receptor (AR) pathway related to CRPC. Our analysis of single-cell sequencing combined with bulk-cell sequencing revealed a substantial downregulation of AR-regulated AFF3 in CRPC. Overexpression of AFF3 restricted the proliferation and migration of prostate cancer cells whilst also increasing their sensitivity towards enzalutamide, while knockdown of AFF3 had the opposite effect. To elucidate the mechanism of tumor inhibition by AFF3, we applied GSVA and GSEA to investigate the metabolic pathways related to AFF3 and revealed that AFF3 had an impact on fatty acids metabolism and ferroptosis through the regulation of ACSL4 protein expression. Based on correlation analysis and flow cytometry, we can speculate that AFF3 can impact the sensitivity of the CRPC cell lines to the ferroptosis inducer (RSL3) by regulating ACSL4. Therefore, our findings may provide new insights into the mechanisms of drug resistance in CRPC, and AFF3 may serve as a novel prognostic biomarker in prostate cancer.
BACKGROUND: Coaches usually reduce the training load (tapering) before competition to improve performance; however, in paralympic athletes this strategy had not yet been tested and we did not know which variables are associated with improved performance. Therefore, the objective was to compare the sleep, mood, sports performance, and reaction time (RT) of paralympic swimmers (PS) during tapering and to investigate whether there is a relationship between the variables during this training phase.
METHODS: Eight PS were monitored for 17 days before the main competition, with an actigraphy to record sleep in 16 days. Evaluations were performed on Mondays (Evaluation 1 = E1) and Fridays (E2) during the first and second weeks (E3 and E4), and on Tuesday (E5) of the third week, the day traveling to the competition. Brunel Mood Scale, RT (Psychomotor Vigilance Test), and sports performance (50 m in the pool) were assessed before training on each assessment day. Internal training load (ITL) was evaluated using ratings of perceived exertion.
RESULTS: ITL decreased gradually between assessments. Performance and RT were better on E5 than on E1. Fatigue was higher on E1 and E2 than on E4 and E5. Sleep parameters (total sleep time [TST], awakenings after sleep onset, and sleep efficiency) improved in the second week compared with the first week. Furthermore, TST from the previous night was correlated with RT, and RT and fatigue correlated with sports performance.
CONCLUSIONS: The increase in TST and the reduction in fatigue just before competition achieved by tapering correlated with the improvement in RT and sports performance. In addition, the tapering improved sports performance, RT, sleep parameters, and decreased fatigue.
PURPOSE:To provide the titled drug preparation for oral administration, having promoted absorptivity in the body and giving continuous drug action, by adding a specific amount of polycarboxylic acid or a hydroxycarboxylic acid to L- pyroglutamyl-L-histidyl-L-prolinamide. CONSTITUTION:The objective drug is prepared by compounding (A) the compound of formula I having the activity to promote the throtropinrelease of the pituitary gland and the action to the central nervous system, or its homologue or acid addition salt having similar activities, with (B) a <=8C polycarboxylic acid (e.g. malic acid, tartaric acid, etc.) or hydroxycarboxylic acid (e.g. lactic acid, gluconic acid, etc.). The weight ratio of B/A is 5-30, preferably 10-20. The homologue of the compound of formula I is e.g. the compound of formula II (A is H, alkyl, aralkyl, alkoxy, etc.; R is group of formula III or formula IV) or its salt. The drug exhibits its activity efficiently at a low dose, and can be administered by the patient himself in the case of continuous and frequent administration to enable the treatment at home.
The Norwegian gastrointestinal cancer group has recommended D3 resection as the standard operative technique for colon cancer. D3 resection implies ligation of the blood vessels at their origin. There is evidence that the recurrence free period and survival improves with the number of lymph nodes harvested at surgery. However, the current practice in Norway, while performing right hemicolectomy for cancer is to ligate the feeding vessels for the right colon on the right hand side of the superior mesenteric vein (SMV). Significant arterial stumps have been demonstrated in patients operated for right colon cancer with this technique (right colic artery and ileocolic artery vascular stumps with an average length of 3.5 cm and 2.5 cm, respectively). This leaves reason to believe that a certain number of central lymph nodes remain after the procedure.

The complex anatomical relationship between the right colic artery and ileocolic artery with the superior mesenteric vein make D3 resection demanding, especially if the right colic artery lies posterior to the SMV. These relationships are investigated in detail in postmortem anatomical studies. These studies show that the right colic artery lies most often anterior to the SMV, while the ileocolic artery lies most often posterior to the SMV. Data has also been provided that a CT angiography can verify these relations as well as postmortem anatomical studies in living patients, thus allowing the surgeon to be aware of them prior to surgery. This could prove to be crucial in planning the procedure.
PURPOSE:To convert toxin produced by microorganism to toxoid and prevent the reversion of toxicity, by treating the toxin with urea, a specific ion and formalin. CONSTITUTION:Toxin produced by microorganism is converted to toxoid by treating the toxin with urea, magnesium ion or a chaotropic ion having lower order in Hofmeister series than chlorine ion (e.g. thiocyanate ion, iodine ion, etc.) and formalin. The chaotropic ion is a general name of univalent anions having large ionic radius and the Hofmeister series corresponds to the effect of such as ion to dissociate a hydrophobic molecule and loosen a hydrophobic bond in a solvent. A toxin having sufficiently high antigenicity and absolutely no toxicity can be produced by this process. The process can be applied to almost all proteinous toxins by simple procedure and is useful from industrial point of view.
The invention relates to 5-aminosalicylic acid of slow- released type in magnetic intercalated structure and the preparation method thereof. The invention has NFe204 of spinel type as magnetic material, LDHs of anion layered material as host, 5aminosalicylic acid as intercalated object. Firstly the spinel nanopowders are added into soluble mixed salt solution comprising metal ion of bivalence and tervalence, then which is intercalation-assembled with alkali solution of 5-aminosalicylic acid, 5ASA-LDHs/NFe204 of supra molecular is thus obtained. Said magnetic 5-amino salicylic acid slow-released formulation is composed of the structure of shell/nucleus type, that is the layered material is coated outside with NFe204 nanoparticles, the specific saturation magnetization of which is 1.0-4.Oemu/g, the particle size of which is around 25-120nm. The invention imparts the medication with magnetism, and the medication is targeted to a focus location by the lead of outside magnetism. The treatment time is reduced and the treatment effect is improved.
BACKGROUND: Type 2 diabetes mellitus represents a multifaceted disorder characterized by intricate pathophysiological mechanisms, encompassing diminished insulin secretion, augmented hepatic glucose production, and heightened insulin resistance. This study aims to assess the sex (Male and Female only) and family history-based differences in the prevalence of T2DM and explore the determinants contributing to this disparity among clinical patients.
SUBJECTS AND METHODS: The study encompassed a diverse pool of clinical patients, encompassing both individuals with diabetes and those without the condition, who had previously sought medical attention for clinical checkups at healthcare centers. The collected data included essential parameters such as blood pressure, weight, height, smoking habits, educational background, and physical activity levels. To ensure methodological rigor and data accuracy, blood pressure measurements adhered to the stringent guidelines set forth by the World Health Organization.
RESULTS: Participants of the present study reported diabetes, among which notable findings emerged regarding health indicators. It was observed that the prevalence of high blood pressure, obesity, and high blood cholesterol exhibited a statistically significant increase among the female participants, underscoring the sex-based disparities in these health parameters. The male population aged 60 or older, the presence of a family history of DM accentuated this risk, resulting in a striking 3.1 times higher prevalence compared to females, who exhibited a 2.4 times higher risk (OR = 2.4, p = 0.0008). This intriguing relationship between diabetes and cholesterol levels was not limited to sex. Both male (OR = 2.47) and female (OR = 2.1) diabetes patients displayed highly significant associations with cholesterol levels. The risk of T2DM was significantly associated with triglycerides in both sexes (1.58 times higher in males, and 1.71 times higher in females).
CONCLUSIONS: The significance of hypertension as a comorbidity in T2DM, highlighting sex-specific associations and the potential impact of a family history of diabetes on blood pressure. Our findings emphasize the importance of considering lipid profiles, obesity, and their sex-specific associations when assessing and managing diabetes risk. Comprehensive diabetes care should include strategies for lipid control, weight management, and cardiovascular risk reduction, tailored to the individual's sex and specific risk profile.
PURPOSE: Understanding the influence of frailty on health-related quality of life (HRQoL) in older individuals experiencing chronic low back pain can provide valuable insights into the impact of frailty. Therefore, the aim of our study is to assess how different frailty statuses among older outpatients with chronic low back pain affect their HRQoL.
METHODS: Patients aged 60 and above with chronic low back pain were recruited from March 2022 to February 2023. Frailty was assessed via the frailty phenotype questionnaire, and HRQoL was evaluated using the EQ-5D-5L. Multiple regression models were used to explore the influence of frailty status on the EQ-5D-5L index and EQ-VAS. Logistic regression was used to determine odds ratios for the impact of frailty status on belonging to the lowest EQ-5D-5L index quartile.
RESULTS: A total of 1,054 participants were classified into robust (29.8%), pre-frail (47.7%), and frail (22.5%) groups. Frailty was significantly associated with declining HRQoL. Pre-frail and frail statuses were inversely linked to the EQ-5D-5L index, with significantly higher odds of scoring in the lowest quartile compared to robust individuals. Stratification analysis identified sex as an effect modifier, emphasizing a more substantial association between frailty and the lowest EQ-5D-5L index quartile in female patients.
CONCLUSIONS: A significant association exists between frailty and reduced HRQoL in patients with chronic low back pain. This association was predominant in female patients. Furthermore, considering the dynamic nature of frailty, early detection and effective interventions targeting pre-frailty are essential to delaying the transition to full frailty and improving HRQoL.
In line with current recommended practice, mothers will be encouraged to provide Kangaroo Mother Care (KMC) whenever possible. If an infant's temp is not rising by ½ degree C per hour with KMC alone, the infant warmer will be offered as an addition by the study team. If the mother is not available for KMC at any time, the infant will be warmed exclusively with the warmer. Bundling in clothes will only be used in addition to the warmer per carer preference. Temp measurement of the infant, warmer, and ambient air will be measured every 15 mins for the first hr, then hrly and as needed for the remainder of use or until warmer endpoint is reached (warmer temp below 36 degrees or phase-change material hardens \[soft, semisoft, or hardened\]).
This is a single-center, double-blind, placebo-controlled, Phase 1a single ascending dose study evaluating the safety, tolerability and pharmacokinetics of sequential doses of oral EC5026 in healthy male and female subjects. EC5026 is an inhibitor of the soluble Epoxide Hydrolase (sEH) enzyme developed as a first-in-class analgesic for the treatment of pain. This study will help refine the dosing strategy for subsequent multiple-dose studies in healthy subjects and for future clinical trials in patients with neuropathic pain.

sEH is an enzyme that is downstream in the cytochrome P450 (CYP) pathway of the arachidonic acid (AA) cascade. The sEH enzyme is responsible of metabolizing a class of epoxy-fatty acids known as epoxyeicosatrienoic acids (EETs), which are potent, naturally occurring analgesics. EETs are produced at high concentrations in areas of tissue damage and inflammation, but are rapidly metabolized by the sEH enzyme into inactive compounds. Effective inhibition of sEH activity prolongs the ability of EETs to exert their analgesic activity.
System and method for dispensing orders. One embodiment provides a pharmacy order delivery and transport system including an enclosure and a transport assembly provided in the enclosure and configured to transport a plurality of filled prescription orders. The transport assembly includes a track extending continuously throughout the enclosure and a plurality of transport blocks connected together to form a continuous loop. Each transport block of the plurality of transport blocks includes a transport hook and a wheel configured to move along the track. The transport hook is configured to receive a storage bag containing a filled prescription order of the plurality of filled prescription orders. The transport assembly also includes a transport actuator configured to drive the plurality of transport blocks along the track.
PURPOSE:A cosmetic having high cleansing and massaging effect, not causing deterioration of quality such as separation, etc., having improved stability free from unpleasant feeling to the skin, obtained by adding a specific amount of synthetic high polymer powder having specified particle diameters to bases during preparation. CONSTITUTION:0.5-30wt% synthetic high polymer powder having 0.01-0.2mm. particle diameters is added to bases during preparation, to give the above-mentioned cosmetic having improved cleansing and massaging effect. A cleansing material as the base may be in a creamy, gel or powdery state, and obtained by common preparation. Similarly, a massaging material may be in a creamy, gel or powdery state. A widely used high polymer material such as a hydrocarbon polymer, polyamide polymer, vinyl polymer, polyester polymer, polyurethane polymer or their copolymers, etc. may be used as the synthetic high polymer powder.
BENICAR HCT contains hydrochlorothiazide which can cause hypokalemia and hyponatremia. Hypomagnesemia can result in hypokalemia which may be difficult to treat despite potassium repletion. BENICAR HCT also contains olmesartan, a drug that inhibits the renin-angiotensin system (RAS). Drugs that inhibit the RAS can cause hyperkalemia. Monitor serum electrolytes periodically.

Hydrochlorothiazide may alter glucose tolerance and raise serum levels of cholesterol and triglycerides.

Hyperuricemia may occur or frank gout may be precipitated in patients receiving thiazide therapy. 

Hydrochlorothiazide decreases urinary calcium excretion and may cause elevations of serum calcium. Monitor calcium levels.