anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Periprosthetic infections caused by Staphylococcus aureus (S. aureus) pose unique challenges in orthopedic surgeries, in part due to the bacterium's capacity to invade surrounding bone tissues besides forming recalcitrant biofilms on implant surfaces. We previously developed prophylactic implant coatings for the on-demand release of vancomycin, triggered by the cleavage of an oligonucleotide (Oligo) linker by micrococcal nuclease (MN) secreted by the Gram-positive bacterium, to eradicate S. aureus surrounding the implant in vitro and in vivo. Building upon this coating platform, here we explore the feasibility of extending the on-demand release to ampicillin, a broad-spectrum aminopenicillin β-lactam antibiotic that is more effective than vancomycin in killing Gram-negative bacteria that may accompany S. aureus infections. The amino group of ampicillin was successfully conjugated to the carboxyl end of an MN-sensitive Oligo covalently integrated in a polymethacrylate hydrogel coating applied to titanium alloy pins. The resultant Oligo-Ampicillin hydrogel coating released the β-lactam in the presence of S. aureus and successfully cleared nearby S. aureus in vitro. When the Oligo-Ampicillin-coated pin was delivered to a rat femoral canal inoculated with 1000 cfu S. aureus, it prevented periprosthetic infection with timely on-demand drug release. The clearance of the bacteria from the pin surface as well as surrounding tissue persisted over 3 months, with no local or systemic toxicity observed with the coating. The negatively charged Oligo fragment attached to ampicillin upon cleavage from the coating did diminish the antibiotic's potency against S. aureus and Escherichia coli (E. coli) to varying degrees, likely due to electrostatic repulsion by the anionic surfaces of the bacteria. Although the on-demand release of the β-lactam led to adequate killing of S. aureus but not E. coli in the presence of a mixture of the bacteria, strong inhibition of the colonization of the remaining E. coli on hydrogel coating was observed. These findings will inspire considerations of alternative broad-spectrum antibiotics, optimized drug conjugation, and Oligo linker engineering for more effective protection against polymicrobial periprosthetic infections.
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Excess levels of circulating androgens during prenatal or peripubertal development are an important cause of polycystic ovary syndrome (PCOS), with the brain being a key target. Approximately half of the women diagnosed with PCOS also experience metabolic syndrome; common features including obesity, insulin resistance and hyperinsulinemia. Although a large amount of clinical and preclinical evidence has confirmed this relationship between androgens and the reproductive and metabolic features of PCOS, the mechanisms by which androgens cause this dysregulation are unknown. Neuron-specific androgen receptor knockout alleviates some PCOS-like features in a peripubertal dihydrotestosterone (DHT) mouse model, but the specific neuronal populations mediating these effects are undefined. A candidate population is the agouti-related peptide (AgRP)-expressing neurons, which are important for both reproductive and metabolic function. We used a well-characterised peripubertal androgenized mouse model and Cre-loxP transgenics to investigate whether deleting androgen receptors specifically from AgRP neurons can alleviate the induced reproductive and metabolic dysregulation. Androgen receptors were co-expressed in 66% of AgRP neurons in control mice, but only in <2% of AgRP neurons in knockout mice. The number of AgRP neurons was not altered by the treatments. Only 20% of androgen receptor knockout mice showed rescue of DHT-induced androgen-induced anovulation and acyclicity. Furthermore, androgen receptor knockout did not rescue metabolic dysfunction (body weight, adiposity or glucose and insulin tolerance). While we cannot rule out developmental compensation in our model, these results suggest peripubertal androgen excess does not markedly influence Agrp expression and does not dysregulate reproductive and metabolic function through direct actions of androgens onto AgRP neurons.
The present invention relates to a traditional Chinese medicine granular preparation for treating rhinitis and a preparation method thereof. The traditional Chinese medicine granular preparation is formed by preparing woodfordia fruticos, houttuynia, meadow sweets, radixes, sweetgum fruit, sagina maxima, centipeda herbs and proper quantities of auxiliary materials. The medicine of the present invention has the efficacy of clearing away heat and toxic material, dispelling wind, relieving edema, relieving a sore throat and promoting the restoration of consciousness, and is used for acute rhinitis, chronic rhinitis, nasosinusitis and laryngopharyngitis which are caused by wind heat. The present invention adopts a cyclodextrin coating technique. Extracted volatile oil is coated in cyclodextrin molecules, and soluble starch and lactose are added in the extracted active substances. Compared with the prior art, the medicine of the present invention has the advantages of good curative effect, good granule hardness, rapid dissolution and absorption, high biological utilization rate, different moisture absorption and deterioration, stable quality, etc.
BACKGROUND: Airway epithelial cells (AECs) are a major component of local airway immune responses. Direct effects of type 2 cytokines on AECs are implicated in type 2 asthma, which is driven by epithelial-derived cytokines and leads to airway obstruction. However, evidence suggests that restoring epithelial health may attenuate asthmatic features.
METHODS: We investigated the effects of passive sensitisation on IL-5, NF-κB, HDAC-2, ACh, and ChAT in human bronchial epithelial cells (HBEpCs) and the effects of fluticasone furoate (FF) and umeclidinium (UME) alone and in combination on these responses.
RESULTS: IL-5 and NF-κB levels were increased, and that of HDAC-2 reduced in sensitised HEBpCs. Pretreatment with FF reversed the effects of passive sensitisation by concentration-dependent reduction of IL-5, resulting in decreased NF-κB levels and restored HDAC-2 activity. Addition of UME enhanced these effects. Sensitized HEBpCs also exhibited higher ACh and ChAT levels. Pretreatment with UME significantly reduced ACh levels, and addition of FF caused a further small reduction.
CONCLUSION: This study confirmed that passive sensitisation of AECs results in an inflammatory response with increased levels of IL-5 and NF-κB, reduced levels of HDAC-2, and higher levels of ACh and ChAT compared to normal cells. Combining FF and UME was found to be more effective in reducing IL-5, NF-κB, and ACh and restoring HDAC-2 compared to the individual components. This finding supports adding a LAMA to established ICS/LABA treatment in asthma and suggests the possibility of using an ICS/LAMA combination when needed.
A myeloid-specific c-fms-rtTA/(TetO) 7 -CMV-MMP12 bitransgenic mouse model was created. Induction of MMP12 abnormally elevated frequencies and numbers of common myeloid progenitor (CMP) and granulocyte/macrophage progenitor (GMP) populations, and decreased the frequency and number of the megakaryocyte/erythrocyte progenitor (MEP) population in bone marrow. CD11b + /Gr-1 +  immature cell population increased in multiple organs. An immunosuppressive function on T cell proliferation and function by CD11b + /Gr-1 +  immature cells was seen in vitro and in vivo from MMP12 over-expression. MMP12 stimulated (Lin − ) progenitor cells to differentiate into CD11b + /Gr-1 +  immature cells showing immunosuppression on T cell proliferation and function in vitro. Regulatory T cells were increased. In the lung, concentration of interleukin (IL)-6 was increased, which activated oncogenic signal transducer and increased expression of Stat3 downstream genes in epithelial tumor progenitor cells. Spontaneous emphysema and lung adenocarcinoma sequentially developed after MMP12 over-expression. MMP12-induced myeloid cell autonomous defect led to abnormal myelopoiesis, immune suppression and lung adenocarcinoma.
The invention comprises a means for reducing infection and/or transmission of viral diseases in mammals. Gene editing complexes, comprising a nuclease and at least one nucleotide directing where the nuclease should act in the genome, are loaded onto nanoparticles. The gene editing bundle-nanoparticle complex is then administered into the mammal and passes through cell membranes to enter the cell, where DNA is edited. Once inside the cells, the gene editing complex edits the DNA. This edit results in the alteration of the expression of the targeted gene in these cells. This invention uses nanoparticles which increase solubility in the cell membrane to deliver the gene editing complex directly into the cell, resulting in non-heritable genetic changes which confer disease resistance.
New onset atrial fibrillation (NOAF) is a common occurrence following cardiac surgery, occurring in 20-30% of patients post-operatively. Historically, Vitamin K antagonist therapy with Warfarin has been the treatment of choice for prophylaxis against stroke and systemic arterial thromboembolism in NOAF. Warfarin inhibits the Vitamin K dependent factors involved in both the intrinsic and extrinsic coagulation cascades, thus decreasing systemic clotting. However, Warfarin therapy comes with many challenges including prolonged titration, tedious monitoring requirements and in some cases, increased bleeding risk.

The limitations associated with Warfarin may be mitigated by using new oral anticoagulants (NOACs) like Rivaroxaban which have no routine monitoring requirements. Rivaroxaban is a direct inhibitor of Factor Xa, a central reactant in both the intrinsic and extrinsic coagulation cascades. Studies in non-operative patients with atrial fibrillation have shown that Rivaroxaban is non-inferior to Warfarin for stroke prophylaxis with similar risk profiles. This study aims to compare the efficacy, safety and financial cost of these two drugs when used for the management of new onset atrial fibrillation that occurs after cardiac operations.
During 12 weeks subjects will exercise during hemodialysis. The intervention will be virtual reality exercise during hemodialysis.
No further renal denervation after standard renal denervation. The definition of non-suppressed is systolic blood pressure rise \>=20 mmHg compared to baseline.
The present invention relates to a medicinal and edible article for preventing and curing acute diarrhea and a preparation method. Traditional Chinese herbal medicines such as radix codonopsis or ginseng, astragalus roots, red poria, etc., are used as raw materials. The medicinal and edible article has the advantages of soft medicinal property, no toxic or side effect, small dosage, good efficiency, fast and obvious curative effect, short curing period and high curing rate. Both the symptom and the cause of a disease can be treated by the formula gripping phenomena of metabolic malfunction of water and food and disease causes of functional disorder of stomaches, intestine, spleens, kidneys and lungs. The preparation method has multiple innovations which greatly enhance medicinal efficiency, the quality and the content of an extract, such as the preparation, the extraction and the application of organic mixed solvent and inorganic mixed solvent, step-by-step extraction at normal temperature and high temperature, etc. The present invention has the advantages of high extraction rate, short production period, energy saving, water saving, low product cost and no pollution of organic solvent. When lactose is adopted to replace starch and dextrin which are easy to digest and absorb to be used as adsorbing agents and filling agents, the slow release speed of medicines is greatly reduced, the medicinal effect is prolonged, and possible medicinal stimulation is relieved to an absolute minimum. People need to be avoided from taking a large quantity of traditional Chinese medicines decocted in water. The medicinal and edible article is water basically and is beneficial to treat and restore the disorder of water metabolism.
Participants in this group will be required to attend the exact same number of sessions as those in the Resistance Training group. Each session will last approximately 45-60 minutes. Sessions will include a practical component/demonstration, an informational video, and a handout on a pertinent healthy lifestyle topic for adults.
1275086 Sugar compositions PENICK & FORD Ltd 14 July 1969 [15 July 1968] 35427/69 Heading A2B [Also in Divisions A5 and C6] A sugar preparation adapted for tabletting contains, as binder or binder-filler, massecuiteaggregated total sugar granules of which the free water content is less than 1 per cent by weight and in which the crystalline phase of the massecuite aggregate is substantially dextrose monohydrate. The granules preferably range in size from 100 to 400 microns and have a dextrose equivalent not less than 88, particularly from 92 to 98. The granules may comprise from 5 to 25 per cent by weight of the composition which additionally may comprise a flavouring, a colouring agent, a tabletting lubricant, a pharmaceutical, a foodstuff, an auxiliary binder or filler, a diluent or a mixture of these. In the preparation of a tablet, the granules are mixed with the other constituents of the finished tablet and unit dose amounts of the mixture are then compressed into tablets, the tablets being afterwards preferably coated with a sealing material. A volatile additive may be incorporated into the granules prior to the mixing step. Examples given include: tablets made from Total Corn Sugar granules blended with 0.1 per cent by weight of magnesium stearate powder as a lubricant; similar tablets made from granules dry blended with an antacid, colouring matter and flavouring additives; sodium chloride tablets made by blending sodium chloride with 10 per cent by weight of spray-drier aggregated Total Corn Sugar granules; fruit drink tablets made by mixing a solution of citric acid in grape juice with spray-drier aggregated corn sugar granules, air drying and mixing with magnesium stearate prior to tabletting; caramel colouring tablets, made in a manner similar to the above; vanillin and vanilla extract flavouring tablets similarly prepared, starting from a solution of the flavourings in alcohol; tablets made from Prednisone, powdered magnesium stearate and the granules; a tablet binding composition made from unpurified molasses and the granules; orangeflavoured beverage tablets using orange oil and an emulsifier and impregnating the granules with this mixed with a solution of citric acid; a chewable tablet using ascorbic acid, sodium ascorbate, the granules and a flavourant; chewable lithium carbonate tablets, which may be sealed with a vegetable oil or fat, a hydrocarbon, or wax, which are sprayed on to the tablets or with an aqueous solution or dispersion of a vegetable gum or other sealing materials, or may be partially sealed using a coating of crystallised sugar; and two further examples of coated tablets, the coatings of which are applicable to the vanillin and Prednisone tablets mentioned above, the preferred coating comprising a sub-coating solution consisting of acacia and corn syrup with syrup U.S.P., a sub-coating powder consisting of precipitated chalk, powdered starch and powdered sugar, and a smoothing solution consisting of powdered sugar with syrup U.S.P.
Understanding the molecular basis of cancer is a critical step toward devising the most effective treatment of the patient as an individual. The promise of molecular targeted therapeutics and personalized cancer care has been demonstrated in breast and lung cancer and chronic myeloid leukemia. However, similar examples of success in multiple myeloma have not been achieved despite extensive basic research as well as clinical advances. What is well understood is that myeloma is a heterogeneous disease with great genetic and epigenetic complexity.22, 23 Therefore, there remains a critical need to understand myeloma patient biology in the context of current patient care.24 The objective of this longitudinal study is to identify patient subgroups and phenotypes defined by molecular profiling and clinical features. These profiles will enable a better understanding of mechanisms of disease, drug response and patient relapse. Ultimately the study is intended to drive successful drug development and patient care in multiple myeloma.
PURPOSE: An antibacterial composition including a plant extract containing tannin as an effective ingredient is provided. The tannin has an excellent antibacterial effect against Propionibacterium acne, Staphylococcus epidermidis and Staphylococcus aureus and is harmless to a human body. Thus, the plant extract containing tannin is used in prevention and treatment of disease caused by cutaneous bacteria. CONSTITUTION: An antibacterial composition contains 0.001 to 20% by weight of tannin contained in an extract of one or more plants selected from Arctostaphylos uva-ursi, Paeoniae Radix rubra, Paeoniae Radix, Lonicerae Flos, Galla Rhois, Quercus infectoria Oliver, Vitis vinifera L., Theae folium, Quercus dentata Thunb. and Mimosa pudica. The antibacterial composition is applied to the affected areas of the skin in a concentration of 0.001 to 1,000mg/ml 1 to 3 times a day.
PURPOSE OF REVIEW: People with schizophrenia experience three to five times higher prevalence of diabetes and obesity than the general population, contributing to a 20-year reduced lifespan. The impacts of weight gain extend beyond physical health, affecting people's self-esteem, quality of life, and triggering treatment nonadherence, leading to relapse and deteriorations in health. Clinical guidelines recommend patients with antipsychotic-induced weight gain are treated with cognitive behaviour therapy and lifestyle changes; however, effective treatments for obesity in schizophrenia are critically lacking. Glucagon-like peptide-1 receptor agonists (GLP-RAs) have shown large effects in weight loss in the general population; however, effects are less clear in people with schizophrenia. This review aims to assess the clinical trials that have been completed, are in progress, and directions for future trials.
RECENT FINDINGS: To date, six clinical trials have been completed, four of which have published their findings. Three further trials are currently in progress.
SUMMARY: Results from completed trials suggest that GLP-1RAs decrease weight in people with schizophrenia, however effect sizes are mostly smaller than studies based on the general population. Future trials could focus on dual or triple agonist agents, and/or explore the effects of GLP-1 s at antipsychotic medication commencement, to potentially prevent antipsychotic weight gain.
<P>PROBLEM TO BE SOLVED: To provide a protein processing with a protease, wherein the protein processing importantly acts at the various stages of biological and physiological phenomena in various processes, and wherein it is useful for clarifying normal and morbid processes that phenomena and mechanisms participated by various proteases are elucidated by a molecular cloning method based on homology.  <P>SOLUTION: Aminopeptidases widely distributed in various living bodies ranging from bacteria to human and performing important roles such as the adjustment in the maturity of proteins and the metabolisms of physiologically active peptides have been noticed and investigated, and a new aminopeptidase gene was consequently identified. The structures of the gene and a protein "aminopeptidase O" encoded in the gene have been elucidated. The protein can be used and measured by the use of a genetic recombination technique or the like. Elucidation means such as physiological and biological activities are available and can be used for physiological phenomena caused by the protein, and for the diagnoses, cause investigation, foresight and the like of related diseases.  <P>COPYRIGHT: (C)2006,JPO&NCIPI
Nivolumab infusion every 3 weeks prior to lymphodepletion chemotherapy with cyclophosphamide/fludarabine, TIL infusion and interleukin-2. Then nivolumab infusion every 4 weeks up to 12 months.
BACKGROUND: Language impairment (aphasia) is a common neurological deficit after strokes. For individuals with chronic aphasia (beyond 6 months after the stroke), language improvements with speech therapy (ST) are often limited. Transcranial direct current stimulation (tDCS) is a promising approach to complement language recovery but interindividual variability in treatment response is common after tDCS, suggesting a possible relationship between tDCS and type of linguistic impairment (aphasia type).
METHODS: This current study is a subgroup analysis of a randomised controlled phase II futility design clinical trial on tDCS in chronic post-stroke aphasia. All participants received ST coupled with tDCS (n=31) vs sham tDCS (n=39). Confrontation naming was tested at baseline, and 1, 4, and 24 weeks post-treatment.
RESULTS: Broca's aphasia was associated with maximal adjunctive benefit of tDCS, with an average improvement of 10 additional named items with tDCS+ST compared with ST alone at 4 weeks post-treatment. In comparison, tDCS was not associated with significant benefits for other aphasia types F(1)=4.23, p=0.04. Among participants with Broca's aphasia, preservation of the perilesional posterior inferior temporal cortex was associated with higher treatment benefit (R=0.35, p=0.03).
CONCLUSIONS: These results indicate that adjuvant tDCS can enhance ST to treat naming in Broca's aphasia, and this may guide intervention approaches in future studies.
Acquire intraoperative MMS measurements in vivo. After assessing this approach on excised tissues, MMS measurements will be aquired directly on the patient from the NMSC excision site. MMS data will be acquired on patients being treated for NMSC at the Austin Dermatologic Surgery Center, the surgical site for the dermatology practice of Seton/University of Texas Physicians group. Similar to the measurements on freshly excised tissues, MMS data will be acquired in a grid pattern on the excision site. The site will be blotted with gauze to remove residual blood prior to the measurement, and continuously blotted as needed until all measurements have been taken. The handheld probe of the MMS enables assessment of both the wound periphery and deeper layers of tissue to determine if any tumor is remaining. For this initial pilot study, we plan to take measurements on 10 patients (5 BCC, 5 SCC), along with corresponding normal tissue measurements.

Retrospective analysis of MMS sensitivity and specificity. The MMS technique is an information rich modality providing both morphological and functional parameters of the interrogated tissue that could be correlated to known tumor pathology. However, this extracted information will require development of sophisticated spectral analysis models which would be beyond the scope of the current study. Therefore, for the purpose of this study, standard statistical techniques will be used to determine the classification power of MMS for tumor margin detection. While this approach does not fully elucidate the underlying pathology responsible for the classification, these types of models have been shown to perform at or better than those based on a morphological approach. This approach has been previously employed to classify skin cancer with high diagnostic accuracy. The final outcome of this study will result in the sensitivity and specificity of MMS compared to histopathology during Mohs surgery. These results will allow for the estimation of the potential benefit of an intraoperative margin assessment technique. This type of retrospective study will provide a proof of concept that would warrant further development and prospective studies of the MMS approach.