anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The prevalence of obesity has a significantly increase in recent years and represents a public health problem due to the increased risk of mortality from various causes. Changes in respiratory system arising from obesity are well established and they include a reduction in compliance with an increased ventilatory work and oxygen consumption with breathing. Bariatric surgery is an alternative surgical treatment of obesity and patients who undergo this surgery are susceptible to post operative pulmonary complications as a result of obesity and also abdominal surgery. The inspiratory muscle training (IMT) used in pre or post operative period can improve muscle strength and endurance, beyond the perception of dyspnea.There are suggestions that the preoperative training may contribute to a best post operative evolution in patients, but these benefits are not clearly defined in the literature. The objective is to evaluate the effects of preoperative IMT in post operative patients undergoing gastroplasty. There will be 40 patients of bariatric surgery group in Ribeirão Preto Medical School of both sexes, BMI\>40 kg/m2 and with the appropriate inclusion criteria.They will be assessed by pulmonary function tests, measurement of strength and endurance of respiratory muscles, submaximal exercise tests, dyspnea and quality of life scales. All patients will receive standard treatment and will be randomly divided into two groups, named control group and training group, who will be trained for 4 weeks preoperatively. The patients will be reassessed after 4 weeks of training and on the 15th postoperative return day. The evolution data about pulmonary complications will be collected from the medical records, notes of the medical staff and physical therapy routine service.
The invention discloses a cream for pregnant women. The skin care medical field acknowledges that skin care during the pregnancy and postpartum is the most important skin care periods for females during the life time. Cosmetics which are sold in the market cannot be used by pregnant women and generally contain ingredients of preservatives, aromatic compounds, pigments and the like which are substances being absolutely impossible to be 'applied' during the pregnancy. The invention provides a special product for the pregnant women to care skin. The cream is characterized in that active mineral substance factor basic liquid which is extracted from broccoli, herba leonuri, sargassum and pearl powder are put into clean water to be soaked; then, the mixture is poured into a ceramic casserole so as to be cooked for 30 minutes through fire and then cooled; and decoction is filtered, filtrate is poured into olive oil to be heated, and water in the filtrate only needs to be completely vaporized. The cream can improve the conditions of skin dehydration, drying and loosening during the pregnancy; and the problem that adverse impacts are caused to babies because the pregnant women use other skin care products is solved.
Traditional physiotherapy techniques were applied to the intervention group. Conventional TENS type was used. Current transition time was set as 50-100 µs. TENS application is performed at a frequency of 100 Hertz for 20 minutes in amplitude that does not cause muscle contraction in the patient and creates a feeling of numbness and tingling. Continuous ultrasound type was applied with full contact technique. Ultrasound treatment was applied over the transverse carpal ligament in the wrist with circular movements towards the proximal and distal at a speed of 1-2.5 cm per second, at a dose of 1 W / cm2, for 6 minutes, with a frequency of 3 MHz. And; tendon-nerve gliding exercises, night splint, stretching and strengthening exercises applied. The treatment was done 3 times a week for 4 weeks.
BACKGROUND: It is unclear what biopsychosocial factors influence the impact of NAFLD on health-related quality of life (HRQoL), and if these factors are equally important predictors between different nationalities.
METHODS: HRQoL (CLDQ) was measured in both Southern European (Spain, n = 513) and Northern European (United Kingdom -UK-, n = 224) cohorts of patients with NAFLD in this cross-sectional study. For each cohort, participant data were recorded on histological grade of steatohepatitis, stage of fibrosis and biopsychosocial variables. Regression analysis was used to explore which of these variables predicted HRQoL. Moderated mediation models were conducted using SPSS PROCESS v3.5 macro.
RESULTS: Participants with severe fibrosis reported more fatigue, systemic symptoms and worry, and lower HRQoL than those with none/mild fibrosis, regardless of place of origin. In addition, body mass index (BMI) and gender were found to be significant predictors of HRQoL in both Spanish and UK participants. Female gender was associated with worse emotional function, higher BMI and more fatigue, which predicted lower participants' HRQoL. UK participants showed more systemic symptoms and worry than Spanish participants, regardless of liver severity. The negative effects of gender on HRQoL through emotional function, BMI and fatigue were reported to a greater degree in UK than in Spanish participants.
CONCLUSIONS: UK participants showed a greater impairment in HRQoL as compared to Spanish participants. Higher fibrosis stage predicted lower HRQoL, mainly in the Spanish cohort. Factors such as female gender or higher BMI contributed to the impact on HRQoL in both cohorts of patients and should be considered in future multinational intervention studies in NAFLD.
BACKGROUND: In recent years, relevant studies have reported that inflammatory cytokines are related to the occurrence of cancer. However, the correlation with lung cancer is not clear. This study used the Mendelian random grouping method to investigate the correlation between inflammatory factors and lung cancer in different populations.
METHODS: We obtained the single nucleotide polymorphisms (SNPs) of inflammatory cytokines through the open database and the SNPs of lung cancer (European and East Asian) through the IEU OpenGWAS project. Inverse variance-weighted (IVW) MR analyses were used to determine the causalities of exposures and outcomes. Supplementary analyses were also performed using weighted median and MR-Egger regressions. Afterward, sensitivity analyses were performed to test the robustness. Search the ChEMBL database for target drugs and indications for CTACK, IL-2, and IL-13.
RESULTS: By IVW method, we found that CTACK, IL-2, and IL-13 were associated with an increased risk of lung cancer in the European population (CTACK, OR = 1.098, 95 % CI 1.001-1.204, P = 0.047; IL-2, OR = 1.112, 95 % CI 1.009-1.225, P = 0.032; IL-13, OR = 1.068, 95 % CI 1.007-1.132, P = 0.029), while only IL-13 was associated with an increased risk of lung cancer in the East Asian population (IL-13, OR = 1.110, 95 % CI 1.010-1.220, P = 0.030). The weighted median and MR-Egger regression methods were in the same direction as the IVW effect sizes. Furthermore, no evidence of multidirectionality was detected using the MR-Egger intercept as a sensitivity analysis. Currently, there are no approved or phase III studied indications for CTACK, IL-2, and IL-13 targets in lung cancer.
CONCLUSION: The study outcomes supported that the inflammatory cytokines CTACK, IL-2, and IL-13 increase the risk of lung cancer. There is a lack of indications for drugs in these three targets. We explored the causal relationship between inflammatory cytokines and lung cancer, providing a basis for future cancer prediction models and targets for anti-tumor therapy.
The goal of this study is to conduct a randomized controlled trial about using Botulinum toxin type A ( BTA) to prevent hypertrophic scar in median sternotomy wound. The entire median sternotomy wound was divided into the upper half and the lower half. Both halves of the wound were randomized to receive treatment with either BTA or 0.9% normal saline. The patient and the surgeon will be blinded to the treatment arm. The primary end point was the evaluation of upper and lower half scar using the Vancouver Scar Scale (VSS). At 6 months follow-up, two blinded dermatologists examined the patients and took photographs of the scar in the outpatient clinic of XiJing Hospital. Scars were assessed using the VSS and assigned the mean score of the two observers. At 6-month follow-up, ultrasonography to measure the scar width will be performed. At the same time, patients were asked to evaluate their overall satisfaction, using a four-point grading scale for each half the scar(1= very satisfied, 2= satisfied,3= slightly satisfied, 4= unsatisfied ).Paired t-test was used to compare the VSS scores, scar width and the overall satisfaction between the BTA-treated group and normal saline group.
PURPOSE: To dye human keratin fibers to color with high gloss in various color gradations exhibiting improved resistance to external causative factors, by applying a combination of a specific oxidation dye and an indole derivative with both hydrogen peroxide and iodine ions to the keratin fibers. CONSTITUTION: Keratin fibers are dyed by applying (A) such a composition at pH 2-7 (pref. pH2-5) as to contain a combination of an indole derivative pref. of the formula (R7 is H, an alkyl, etc.; R8 and R9 are each H, an alkyl, carboxyl, etc.; R10 and R11 are each H, an alkyl, formyl, an acyl, etc.) and an oxidation dye selected from rapid oxidation dyes and couplers with iodine ion or hydrogen peroxide in a medium suitable for dyeing and (B) such another composition at pH2-12 (pref. pH2-7) containing hydrogen peroxide in a medium suitable for dyeing when the composition A contains iodine ion, or at pH3-11 containing iodine ion when the composition A contains hydrogen peroxide, to the keratin fibers, in any order.
Application of TGR5 in preparing medicines for treating intestinal cancer and diagnostic kits belongs to the field of biological medicines. According to the TCGA database, the TGR5 gene was shown to be significantly less expressed in intestinal cancer tissues than in normal tissues. The research detects the expression level of TGR5 gene in intestinal cancer and paracancer normal tissue through real-time fluorescent quantitative PCR, proves that the expression level of TGR5 gene in intestinal cancer tissue is obviously lower than that of paracancer normal tissue, and can use TGR5 gene as the detection target of an intestinal cancer diagnosis kit. A large number of cell experiments prove that the activation of TGR5 can inhibit the proliferation and migration of intestinal cancer cells. The real-time fluorescent quantitative PCR technology proves that the activation of TGR5 can significantly reduce the expression of cancer-related genes MMP7, MMP9, INOS and CCL2 at the mRNA level. The invention discloses good application of TGR5 in preparing an intestinal cancer diagnostic kit and an intestinal cancer targeted therapeutic drug.
According to the present invention, a specific  Lactobacillus  sp. strain, a specific  Bifidobacterium  sp. strain, a specific  Streptococcus  sp. strain or a specific  Collinsella  sp. strain is isolated from human feces, and thus has high safety, and has various physiological activities such as an immune regulatory effect, an immune enhancement effect, an anti-allergic effect, an anti-inflammatory effect, a colitis alleviation effect, an arthritis alleviation effect, an anti-obesity effect, an anti-stress effect, an anti-anxiety effect, an anti-depression effect or an anti-schizophrenia effect. According to the present invention, the specific  Lactobacillus  sp. strain, the specific  Bifidobacterium  sp. strain, the specific  Streptococcus  sp. strain or the specific  Collinsella  sp. strain can be used as a material for immune regulation, immune enhancement, inflammatory response inhibition, and stress alleviation, and can also be used as a functional food and pharmaceutical material useful for preventing, alleviating or treating allergic diseases, inflammatory diseases, colitis, arthritis, obesity, anxiety disorders, depression, schizophrenia or the like.
Systems, apparatus, and methods for training plan delivery and workout logging. In one embodiment of the present disclosure, a fitness tracking system and/or community of personal devices: (i) generates a training plan, (ii) schedules and coordinates delivery of workouts based on the training plan, and (iii) notifies the user of workouts via one or more wearables. In one exemplary embodiment, a fitness tracking system generates a training plan based on user workout history and/or user input. Thereafter, suggested workouts can be pushed to the user's community of personal devices, via a coordinating device (e.g., a smart phone). The coordinating device manages and controls workout notifications for any available coordinated devices (e.g., smart watches, smart shoes, etc.) Unlike previous systems, the disclosed embodiments of the present disclosure integrate a community of different personal devices together so as to capture activity tracking data regardless of what a user is wearing.
A 32-year-old man, who was treated for T-cell lymphoma, presented in cardiac arrest. He had been treated for heart failure with reduced ejection fraction. Veno-arterial extracorporeal membrane oxygenation was initiated immediately. We diagnosed him as non-ST elevated myocardial infarction. Coronary angiography demonstrated the occlusion of the trifurcation in the proximal left anterior descending artery (LAD). We failed to advance the first guidewire into the distal LAD by angio-based conventional wiring. Intravascular ultrasonography (IVUS) of the proximal diagonal branch revealed two diaphragms separating the distal lumen without connection, which looks like lotus root-like appearance. We quickly penetrated the plaque using IVUS-based real-time 3D wiring using the tip detection method. The contrast injection via the microcatheter showed the distal diagonal branch (D2). After the balloon dilation in D2, IVUS image revealed a torn plaque between D2 and the distal LAD. Subsequently we advanced the guidewire to the distal LAD using IVUS-based real-time 3D wiring using the tip detection method through the tear of the plaque. Finally, we successfully performed the revascularization of LAD in a preferable procedure time. The patient recovered well and was discharged 39 days after cardiac arrest. This case highlights the efficacy of IVUS-based real-time 3D wiring using the tip detection method even in the emergent and challenging situation.
Despite advances in therapies, glioblastoma (GBM) recurrence is almost inevitable due to the aggressive growth behavior of GBM cells and drug resistance. Temozolomide (TMZ) is the preferred drug for GBM chemotherapy, however, development of TMZ resistance is over 50% cases in GBM patients. To investigate the mechanism of TMZ resistance and invasive characteristics of GBM, analysis of combined RNA-seq and ChIP-seq was performed in GBM cells in response to TMZ treatment. We found that the PERK/eIF2α/ATF4 signaling was significantly upregulated in the GBM cells with TMZ treatment, while blockage of ATF4 effectively inhibited cell migration and invasion. SPHK1 expression was transcriptionally upregulated by ATF4 in GBM cells in response to TMZ treatment. Blockage of ATF4-SPHK1 signaling attenuated the cellular and molecular events in terms of invasive characteristics and TMZ resistance. In conclusion, GBM cells acquired chemoresistance in response to TMZ treatment via constant ER stress. ATF4 transcriptionally upregulated SPHK1 expression to promote GBM cell aggression and TMZ resistance. The ATF4-SPHK1 signaling in the regulation of the transcription factors of EMT-related genes could be the underlying mechanism contributing to the invasion ability of GBM cells and TMZ resistance. ATF4-SPHK1-targeted therapy could be a potential strategy against TMZ resistance in GBM patients.
The dosage for premature infants starts at 0.5 g fat/kg body weight/24 hours (2.5 mL Intralipid 20%) and may be increased in relation to the infant's ability to eliminate fat. The maximum recommended dosage is 3 g fat/kg/24 hours. 

Pediatric patients may be at risk for parenteral nutrition-associated liver disease (PNALD), also known as intestinal failure-associated liver disease (see WARNINGS section) when receiving Intralipid for durations exceeding two weeks. During intravenous administration of Intralipid 20%, perform liver tests to monitor for PNALD. 

The initial rate of infusion in older pediatric patients should be no more than 0.01 g fat/minute for the first 10 to 15 minutes. If no untoward reactions occur, the rate can be changed to permit infusion of 0.1 g of fat/kg/hour. The daily dosage should not exceed 3 g of fat/kg of body weight3. Intralipid (equivalent to 0.125 g/kg/hour) should make up no more than 60% of the total caloric input to the patient. Carbohydrate and a source of amino acids should comprise the remaining caloric input.
Patients scheduled for unilateral primary TKA; 108 patients were randomly assigned to receive peri-articular TXA, intraarticular TXA and control group. 36 patients received either: (I) 15 mg/kg peri-articular TXA combined with multimodal local anesthetic infiltration (bupivacaine, morphine, ketorolac and epinephrine) into the anterior soft tissue, medial gutter area, lateral gutter area prior to capsular closure and tourniquet deflation (group 1). (II) 2 g of intraarticular TXA after complete capsular closure just before tourniquet deflation (group 2). (III) Don't receive any route of TXA in control group (group 3). Hemoglobin (Hb) concentrations were measured at 24 and 48 hour, and the number of blood transfusions and knee circumference measurements were recorded. Serum TXA was recorded at 2 and 24 hours after operation. The reviewers were blinded to treatment group.
BACKGROUND: Tissue expansion is a powerful tool in reconstruction of pediatric soft-tissue pathologies, but complication rates in children have been reported to be as high as 40%. Infection and implant extrusion lead to premature removal and delays in reconstruction. Expanding the head and neck is uniquely challenging because the confluence of facial aesthetic units must be respected. These challenges prompted the senior author (R.J.R.) to create an aesthetic unit-based algorithm.
METHODS: A retrospective study of pediatric patients who underwent cervicofacial tissue expander placement over a 17-year period was performed by the senior author. Predictor variables included age, sex, race, indication, number of expanders placed at each operation, serial expansion, expander type, expander size, home versus clinic inflation, and prophylactic antibiotics. Univariate and multivariate analyses were performed to identify risk factors for complications.
RESULTS: An aesthetic unit-based reconstructive algorithm is proposed. Forty-eight pediatric patients had 111 cervicofacial tissue expanders placed. Twenty expanders were associated with complications (18%) for surgical site infection (12.6%), extrusion (4.5%), or expander deflation (6.3%). Expanders placed for congenital nevi ( P = 0.042) and use of textured expanders ( P = 0.027) were significantly associated with decreased complication levels. When controlling for covariates, serial expansion of the same site was associated with increased rate of readmission ( P = 0.027) after having just 1 previous expander. Iatrogenic ectropion occurred in 13.5% of the study population; expanders with at least 1 complication during tissue expansion were significantly associated with incidence of iatrogenic ectropion ( P = 0.026).
CONCLUSION: By using an aesthetic unit-based algorithm, reconstructive outcomes can be optimized for pediatric cervicofacial tissue expansion.
CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.
Comparator ref product: EU Stelara (ustekinumab) Initial loading dose of 45 mg followed by 45 mg SC once every 12 weeks starting 4 weeks after the initial loading dose administered SC. Injected as subcutaneous in thigh and abdomen.
BACKGROUND: Patients with peripheral arterial disease have an increased risk of developing cardiovascular complications in the postoperative period of arterial surgeries known as Major Adverse Cardiac Events (MACE), which includes acute myocardial infarction, heart failure, malignant arrhythmias, and stroke. The preoperative evaluation aims to reduce mortality and the risk of MACE. However, there is no standardized approach to performing them. The aim of this study was to compare the preoperative evaluation conducted by general practitioners with those performed by cardiologists.
METHODS: This is a retrospective analysis of medical records of patients who underwent elective arterial surgeries from January 2016 to December 2020 at a tertiary hospital in São Paulo, Brazil. The authors compared the preoperative evaluation of these patients according to the initial evaluator (general practitioners vs. cardiologists), assessing patients' clinical factors, mortality, postoperative MACE incidence, rate of requested non-invasive stratification tests, length of hospital stay, among others.
RESULTS: 281 patients were evaluated: 169 assessed by cardiologists and 112 by general practitioners. Cardiologists requested more non-invasive stratification tests (40.8%) compared to general practitioners (9%) (p < 0.001), with no impact on mortality (8.8% versus 10.7%; p = 0.609) and postoperative MACE incidence (10.6% versus 6.2%; p = 0.209). The total length of hospital stay was longer in the cardiologist group (17.27 versus 11.79 days; p < 0.001).
CONCLUSION: The increased request for exams didn't have a significant impact on mortality and postoperative MACE incidence, but prolonged the total length of hospital stay. Health managers should consider these findings and ensure appropriate utilization of human and financial resources.
Anal carcinoma is a disease in which modern therapy is reasonably successful in achieving tumour control/cure. Both acute and late side effects are substantial. Proton radiotherapy is hypothesised to have the potential to decrease the incidence/severity of some acute side effects from certain organs at risk e.g. bone marrow and intraperitoneal bowel. By sparing the dose to these organs it is also possible that late effects might be less evident. Sparing of the bone marrow may lead to fewer septic events and dose reductions of chemotherapy which may, as a consequence, improve tumour control. The primary aim of this study is to find ways to decrease acute side effects primarily to alleviate some discomfort from the patient during and after a usually painful treatment experience. It has also been concluded by others that reduction of acute side effects is a relevant aim and end point for the evaluation of new treatment techniques and both patient reported and physician reported data are assessed
The invention describes a gut-protective composition comprising boswellic acid, at least one pH modifier, wherein the composition exhibits enhanced dissolution. The composition as described herein may be comprised of about 5 to 95% of boswellic acid. The said composition is stable and exhibits improved bioavailability. The invention also provides a process for preparation of the said composition, wherein boswellic acid and pH modifier are mixed well by optionally adding at least one or more excipient and processed to get granular powder. The composition may be further formulated into solid, semi solid or liquid dosage forms, for administration to human or animals. The compositions described herein exhibit gut-protective effect in conditions of colitis as well as microbial infections.