anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: To produce the subject new substance having ameliorating actions on cancerous cachexia and useful as a cancer chemotherapeutic agent, etc., by culturing a microorganism, belonging to the genus Sporothrix and having the ability to produce the substance for attenuating interleukin-6 (IL-6) activities. CONSTITUTION: This new substance for attenuating IL-6 activities as chlovalicin has the following properties of assuming a colorless oily substance and having 332 molecular weight [measured according to the fast atom bombardment (FAB) mass spectrometry] and a molecular formula C16 H25 O5 Cl (measured by high- resolution mass spectrometry) and soluble in acetone, ethyl acetate, ethyl ether, hexane, methanol, ethanol, chloroform and benzene and sparingly soluble in water. A microorganism, belonging to the genus Sporothrix and having the ability to produce the substance for attenuating IL-6 activities [e.g. Sporothrix sp. FO-4649 (FERM P-14796)] in a culture medium to afford the chlovalicin. The substance has ameliorating actions on cancerous cachexia caused by malignant degeneration of lung cancer, cancer of the liver, carcinoma of the colon, prostatic cancer, etc.
Germinated-activated Ganoderma lucidum spores are useful in the manufacture of medicament for treating immunological disorder in mammals. An independent claim is also included for a systemic lupus erythematosus agent, contains the germinated-activated Ganoderma lucidum spores. ACTIVITY : Immunosuppressive; Antiinflammatory; Dermatological. NIH small white mice (6-8 weeks old) were orally administered with 0.60 g/kg body weight of Ganoderma lucidum spores 10 times a day for 4 weeks. A control was similarly performed with cold distilled water. 4 days before the end of the test the animals were intraperitoneally injected with 0.2 ml of sheep erythrocytes and 4 days after the test the animals were subcutaneously injected with sheep erythrocytes. The results showed that administration of Ganoderma lucidum spores delayed allergic reactions in test group (standard deviation of thickness of foot pad was 0.68+-0.10), than the control (standard deviation of thickness of foot pad was 0.43+-0.16). The results indicated that G.lucidum spores had significant effective in delaying allergic reactions. MECHANISM OF ACTION : None given.
PURPOSE: To knead a raw material to be kneaded with good productivity without damaging the quality thereof by lowering the temp. of the raw material to be kneaded by setting the part where helical gears meshed with each other are not arranged of a mashing kneading chamber to a cooling region and disposing this cooling region on the side of a supply port with respect to a discharge port. CONSTITUTION: When a raw material to be kneaded is supplied to a mashing kneading chamber 3 from a supply port, the raw material enters the tooth grooves between the teeth of helical gears 15a, 15b, 16a, 16b to be fluidized and kneaded in the tooth grooves and the gaps between the outer peripheries of the gears and the inner periphery of a barrel 2 by the rotation of respective shafts 6, 7. At this time, large shearing energy is applied to the raw material by the helical gears 15a, 15b, 16a, 16b and the raw material raised in temp. by shearing energy is cooled in cooling regions 20a, 20b. By this constitution, productivity is enhanced and the temp. of the raw material to be kneaded is lowered and the adverse effect on the raw material to be kneaded containing a substance having temp. dependence is eliminated.
The present invention provides a kind of scald pain-stopping plasters and preparation method thereof.Preparation method is as follows：（1）Beadplant, Thuidium cymbifolium (Doz. Et Molk.) Doz. Et Molk, gold phoenix, Buddhist temple dish, Flos Hibisci Mutabilis, castor-oil plant fruit root, Tibetan schizonepeta, Alysicarpus bupleurifolius (L) DC is taken to grind respectively；（2）Prepare beadplant, Thuidium cymbifolium (Doz. Et Molk.) Doz. Et Molk, gold phoenix, Alysicarpus bupleurifolius (L) DC extract；（3）Natural beeswax, medicinal terpene resin, medicinal vaseline, azone, dimethyl sulfoxide, red halloysite, borneol are mixed, stirring at low speed is heated to being completely melt；（4）After cooling, it adds Buddhist temple vegetable powder, lotus pollen, castor-oil plant fruit root powder, hide schizonepeta powder, beadplant extract, Thuidium cymbifolium (Doz. Et Molk.) Doz. Et Molk extract, gold phoenix extract, Alysicarpus bupleurifolius (L) DC extract, it stirs evenly, naturally cools to room temperature, be attached on medical air-permeable adhesive tape.The scald pain-stopping plaster of the present invention has effects that scald well to relieve pain, and wound can be promoted to form a scab, and has the effect of notable for scald.
Group 3 patients will take 50%, 80%, or 100% of their usual insulin glargine dose. Which of those three percentages will be determined by the midpoint of the patient's usual self-reported fasting blood sugar (FBS) range and whether the patients is also taking a rapid-acting insulin.
Comparing the effect of two different formulations of paracetamol (effervescent or non-effervescent tablets) in the blood pressure of hypertensive patients after 3 weeks treatment . The washing time between the two periods is approximately 1 week (minimum 3 days).
Three cases of overdose were reported in controlled clinical trials with dalfampridine extended-release tablets, involving two MS patients. The first patient took six times the currently recommended dose (60 mg) and was taken to the emergency room with altered mental state. The second patient took 40 mg doses on two separate occasions. In the first instance, she experienced a complex partial seizure and, in the second instance, a period of confusion. Both patients recovered by the following day without sequelae.  
  
Several cases of overdose are found in the scientific literature in which various formulations of dalfampridine were used, resulting in numerous adverse events including seizure, confusion, tremulousness, diaphoresis, and amnesia. In some instances, patients developed status epilepticus, requiring intensive supportive care and were responsive to standard therapy for seizures. In one published case report, an MS patient who ingested 300 mg of 4-aminopyridine (dalfampridine) developed a condition that resembled limbic encephalitis. This patient developed weakness, reduced awareness, memory loss, hypophonic speech, and temporal lobe hyperintensities on MRI. The patient’s speech and language and ambulation improved over time, and an MRI at 4 months after the overdose no longer showed signal abnormalities. At one year, the patient continued to have difficulty with short term memory and learning new tasks.
FIELD: medicine. SUBSTANCE: method includes intravenous introduction of antibiotic in minimum single dose. Simultaneously blood is irritated by red laser. Power at light-guide end equals 2 mW. Blood may be irradiated by infrared laser at 1 mW power. Wound surface is exposed to red laser irradiation at power density of 10-20 mW/sq.cm or to infrared laser irradiation at power density of 5-10 mW/sq.cm. Wound surface exposure is performed either at beginning of phase of antibiotic removal from blood or before intravenous irradiation of blood. Then antibiotic application in maximum therapeutic doses is carried out. Given method allows reduced tissue resorption of fine-dispersed compounds and medicinal preparations from wound surface to organism. EFFECT: improved treatment results. 5 tbl, 3 dwg
Methods and systems for managing a user's health habits. Various embodiments of the invention allow the user to register habits to a habit registry. Relevant sensor and other data is collected contemporaneously with the registration of the behavior and is stored in association with the registered habit. In normal use, a configured processor attempts to detect occurrences of a previously registered habit by comparing subsequently collected data to previously stored data. When collected and stored data match, a registered health habit is detected, the occurrence may be added to a health habit log, and the feedback may be provided to the user. The feedback assists the user to achieve his goals in health habit management.
Invadosome is an umbrella term used to describe a family of cellular structures including podosomes and invadopodia. They serve as contact zones between the cell plasma membrane and extracellular matrix, contributing to matrix remodeling by locally enriched proteolytic enzymes. Invadosomes, which are actin-dependent, are implicated in cellular processes promoting adhesion, migration, and invasion. Invadosomes, which exist in various cell types, play crucial roles in physiological phenomena such as vascularization and bone resorption. Invadosomes are also implicated in pathological processes such as matrix tissue remodeling during metastatic tumor cell invasion. This review summarizes basic information and recent advances about mechanisms underlying podosome and invadopodia formation, their organization and function.
The design was a multi-site 8-month randomized, controlled clinical trial with the patient as the unit of randomization. The Institutional Review Board at the Medical University of South Carolina approved the study. The setting included 9 pharmacies within a medium-sized grocery store chain in South Carolina. The 9 pharmacies were selected to ensure an adequate sample size and sufficient representation by patients with respect to geographic region (urban, suburban, and rural), race/ethnicity, and socioeconomic background. Individual pharmacy staff were informed by their district manager (P.P.) that they were required to participate in the project. Beginning January 16, 2006 and continuing through August 29, 2006, all patients who were at least 7 days overdue for a qualified prescription were identified on a weekly basis (i.e. every Monday morning) using the centralized computer database. Patients identified as being overdue for a qualified medication were assigned a unique study identification number and randomized using a simple randomization technique operationalized within a Microsoft® Access® database. The randomization was based on a permuted block design with a block size of 3, with each patient thus having a one-third chance of being placed in any one of the 3 treatment arms.After eligible patients were identified and randomized each week, there were 3 different protocols followed, depending on the assigned treatment arm. The 3 treatment arms included 1) pharmacist contact with the patient via telephone, 2) pharmacist contact with the prescribing physician via facsimile, and 3) usual care.There were a total of 3,048 patients into arms 1 (n=1018), 2 (n=1016), and 3 (n= 1014). The study was designed to detect relatively small differences in the outcomes of interest. Baseline comparisons across treatment arms in the characteristics of patients and medications were made using t-tests and chi-square tests, as appropriate. For the analyses of study outcomes, an intent-to-treat approach was used. Statistical models were constructed to compare outcomes among the 3 treatment arms, after first examining whether significant interaction between treatment arm and medication disease classification was present. For the analyses of secondary outcomes, all of which were binary in nature, multivariable logistic regression models were used, with treatment arm as the key independent variable of interest, adjusting for the same covariates used in the primary analyses.
The induction dose requirements of DIPRIVAN may be reduced in patients with intramuscular or intravenous premedication, particularly with narcotics (e.g., morphine, meperidine, and fentanyl, etc.) and combinations of opioids and sedatives (e.g., benzodiazepines, barbiturates, chloral hydrate, droperidol, etc.). These agents may increase the anesthetic or sedative effects of DIPRIVAN and may also result in more pronounced decreases in systolic, diastolic, and mean arterial pressures and cardiac output.

During maintenance of anesthesia or sedation, the rate of DIPRIVAN administration should be adjusted according to the desired level of anesthesia or sedation and may be reduced in the presence of supplemental analgesic agents (e.g., nitrous oxide or opioids). The concurrent administration of potent inhalational agents (e.g., isoflurane, enflurane, and halothane) during maintenance with DIPRIVAN has not been extensively evaluated. These inhalational agents can also be expected to increase the anesthetic or sedative and cardiorespiratory effects of DIPRIVAN.

The concomitant use of valproate and propofol may lead to increased blood levels of propofol. Reduce the dose of propofol when co-administering with valproate. Monitor patients closely for signs of increased sedation or cardiorespiratory depression.

DIPRIVAN does not cause a clinically significant change in onset, intensity or duration of action of the commonly used neuromuscular blocking agents (e.g., succinylcholine and nondepolarizing muscle relaxants). 

No significant adverse interactions with commonly used premedications or drugs used during anesthesia or sedation (including a range of muscle relaxants, inhalational agents, analgesic agents, and local anesthetic agents) have been observed in adults. In pediatric patients, administration of fentanyl concomitantly with DIPRIVAN may result in serious bradycardia.
The present invention relates to a pill for chronic colonitis and a preparation method thereof, which belongs to a pure traditional Chinese medicine watered pill preparation for treating chronic colonitis. The preparation is prepared from costusroot, raw licorice root, Tiantai radix linderae, medicated leaven, large radix paeoniae alba, tine betel nut, filed oriental wormwood, radix scutellariae, Chuan rhizoma coptidis, codonopsis pilosula, poria cocos, stir-baked white atractylodes rhizome, prepared radix glycyrrhiza, fructus psoraleae, dodder, Chinese teasel root, northern scutellaria root, northern schisandra fruit and roasted nutmeg. The preparation has the advantages of reasonable compatibility, chosen prescription and no prognosis recurrence. In the clinical application for forty years, the cure rate of the preparation is 98%. The preparation method comprises: selecting genuine medicinal materials, grinding the medicinal materials into powder after cleaning by picking, sieving with the sieve of 80 meshes, grinding with water to prepare every pill of 1 gram, separately loading the pills in every bottle of 120 granules, and sealing for storage. After being taken for a long time, the product has no side effect, and patients are forbidden to eat uncooked, cold, greasy and pungent foods during the period of taking the medicine. The medicine is taken for three times every day, and 15 to 30 pills are taken every time with warm boiled water. One course of treatment is one month, and the course of ulcerative colitis treatment is three months.
The present invention describes a process for isolation of romidepsin from fermentation broth and preparation of crystals of romidepsin. The process of the invention includes fewer purification steps and provides romidepsin having purity of greater than 99.5% area by HPLC. The process of the invention involves simple purification steps and hence, does not require multiple chromatographic purification steps to achieve desired quality of romidepsin. The process is advantageous over reported processes in terms of 99.5 % pure yield, fast process, less expensive and less cumbersome as multiple chromatographic purification is not necessary to achieve desired quality. The process for the preparation of crystals of romidepsin provides advantages like simple steps and involves use of single solvent. The process is advantageous in terms of time, cost, and simplicity.
Subjects received 2 doses of vaccine formulated from VT strain, 1 at Day 0 and 1 at Month 6. The vaccine was administered in the deltoid region of the non-dominant arm.
BACKGROUND: The effects of the menstrual cycle in women with and without primary dysmenorrhea on phase-related postural sensory organization are controversial.
RESEARCH QUESTION: This study was carried out to examine postural sensory organization in three phases of the menstrual cycle in women with and without primary dysmenorrhea and to evaluate whether there is a difference between women with/without primary dysmenorrhea in this regard.
METHODS: Women aged 18-30 years were divided into two groups as primary dysmenorrhea group (PDG, n = 14) and control group (CG, n = 15). Computerized dynamic posturography were applied to the participants on the follicular, ovulation, and luteal phases of the menstrual cycle. Outcome measures were antero-posterior and medio-lateral Sensory Organization Test (SOT-somatosensory, vestibular and visual scores) and Limits of Stability test (LoS). The findings obtained were analyzed with the two-factor ANOVA, paired samples t test, and independent samples t test.
RESULTS: In the PDG, follicular phase antero-posterior somatosensory scores were lower compared to luteal phase (p = 0.002). Follicular phase antero-posterior and medio-lateral vestibular scores were lower than ovulation (p = 0.003, p = 0.004, respectively) and luteal (p = 0.005, p = 0.001, respectively) phases. Follicular phase LoS scores were lower than ovulation (p = 0.001) and luteal (p = 0.002) phases. In the CG, ovulation phase antero-posterior somatosensory scores were lower than follicular phase (p = 0.003). Follicular phase LoS scores were lower than ovulation phase (p = 0.002). The PDG had lower follicular phase antero-posterior somatosensory (p = 0.019), vestibular (p = 0.031), and medio-lateral somatosensory (p = 0.019) scores than those of the CG. The PDG had lower luteal phase antero-posterior somatosensory scores than those of the CG (p = 0.029). The PDG showed lower follicular phase LoS scores than those of the CG (p = 0.009).
SIGNIFICANCE: This study revealed that primary dysmenorrhea impairs postural sensory organization. Decreased sensory organization may predispose women to injury. The risk of injury should be investigated and necessary precautions should be taken.
In view of the drawbacks of the prior art, an object of the present invention is to propose a pharmaceutical composition for ophthalmic use, which can increase the effect of absorbing the effective cost of eye drops for the average user. Aiming at the problem of excessive use of the sustained-release eye drops by patients, the sustained-release eye drop plays a role in prompting harmless abnormal reactions to eyes. To achieve the object, the invention consists of the following components: active ingredient, ganciclovir, boric acid, sodium chloride, disodium edentate, hypromellose, and povidone. According to the invention, ganciclovir is selected to be combined with other main active ingredients to generate a synergistic effect, and povidone is adopted to obviously improve the viscosity of the product. Through high viscosity, the form informs the patient that the eye drops are overused today, and effectively prompts the patient to stop continuously using the eye drops. Thus, the excessive use of the eye drops is warned through the sense of the body, and the eye drops are very visual and effective. And the absorption rate of the active ingredients of the medicine is higher than that of similar products.
OBJECTIVES: Maternal stress has long been associated with lower birthweight, which is associated with adverse health outcomes including many adult diseases. The underlying mechanisms remain elusive although changes in gene expression may play a role. Studies are only beginning to test how maternal stress impacts gene expression as reflected in the transcriptome.
MATERIALS AND METHODS: In a cohort of mothers and newborns in the eastern Democratic Republic of Congo (n=93), we studied the effects of four maternal stress measures (chronic stress, war trauma, sexual trauma, and general trauma) on the transcriptomes of maternal venous blood, newborn venous blood, and placental tissues, and on newborn birthweight. Maternal stress was investigated as independent measures, principal components, and clusters identified through machine learning. The transcriptome was assayed using the ClariomD chip. Multiple regression models were used to test for associations between maternal stress measures, the transcriptome, and newborn birthweight.
RESULTS: None of the maternal stress measures showed an association with expression of individual genes. In contrast, when testing global gene expression, war trauma was significantly associated with the placental transcriptome. War trauma was also significantly associated with birthweight in multiple models. Mediation analysis indicated that ~14% of the effect of war trauma on birthweight was mediated by a placental gene expression component.
DISCUSSION: Our results suggest that gene expression in the placenta, which represents the interface between mother and developing fetus, may partially mediate the negative impact of maternal stress on newborn birthweight.
<P>PROBLEM TO BE SOLVED: To provide an excellently serviceable, water-based gel-like cosmetic that is excellent in effects for providing the skin with a tightness feeling and is suppressed in a slimy feeling during cosmetic application or a sticky feeling after cosmetic application.  <P>SOLUTION: The water-based gel-like cosmetic comprises a micronized solid oil powder dispersed in water. The water-based gel-like cosmetic comprises the solid oil powder micronized by an in-gas evaporation method that is dispersed in water. In the water-based gel-like cosmetic, the average particle size of the solid oil powder is 100 nm to 1 μm. In the water-based gel-like cosmetic, the melting point of the solid oil powder is 40-80°C.  <P>COPYRIGHT: (C)2006,JPO&NCIPI