anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: A pharmaceutical composition containing Alpinia katsumadai hayata extract, fraction or triterpenoid compounds is provided to prevent and treat metabolic disease of type 2 diabetes, obesity, dyslipidemia, insulin resistance, hepatic steatosis, non-alcoholic fatty liver. CONSTITUTION: A pharmaceutical composition for preventing and treating metabolic diseases contains Alpinia katsumadai hayata extract. The Alpinia katsumadai hayata extract is isolated using water, alcohol or mixture thereof. A pharmaceutical composition for preventing and treating metabolic diseases contains fraction obtained by fractioning the Alpinia katsumadai hayata extract using organic solvent. A pharmaceutical composition for preventing and treating metabolic diseases contains triterpenoid compounds of chemical formula 1 or pharmaceutically acceptable salt as an active ingredient. A pharmaceutical composition for preventing and treating metabolic diseases contains tripertenoid compounds of chemical formula 2 or pharmaceutically acceptable salt as an active ingredient. The compounds of chemical formulas 1 and 2 are isolated from Alpinia katsumadai hayata.
Optic perineuritis is the inflammation of the optic nerve sheath. This affliction can lead to visual field impairment and other signs and symptoms related to the orbital space, such as pain, disc edema, ophthalmoplegia, proptosis. However, not all patients present with such suggestive symptoms, requiring a thorough assessment. We report the case of a young male admitted to our hospital for recurrent episodes of monocular blindness. Amaurosis fugax is a well-known presentation of transient ischemic attacks (TIA) and it was ruled out. Gadolinium-enhanced MRI revealed a typical aspect of optic perineuritis. It was mandatory to consider all possible causes of secondary optic perineuritis as they all represent serious clinical conditions, even if the idiopathic form is more frequent. The clinical and paraclinical evaluation of the patient excluded an underlying disease and primary optic perineuritis was diagnosed. Corticosteroid therapy is usually curative and a course of methylprednisolone was initiated for our patient with good outcome. However, response to treatment is not diagnostic as both primary and secondary optic perineuritis are normally responsive, hence thorough differential diagnosis is necessary.
<P>PROBLEM TO BE SOLVED: To provide a medicine having excellent decorativeness and a metal film.  <P>SOLUTION: The medicine 1 is formed into a solid shape such as a granular shape or a tablet shape. The metal film 3 composed of an edible metal such as gold, silver or platinum is formed on the surface of the body of the medicine 1 (i.e. the medicine body 2) by sputtering. Thereby, the metal film 3 composed of the edible metal such as the gold, silver or platinum on the surface of the medicine body 2 is formed by the sputtering and the metal film 3 can be homogenized.  <P>COPYRIGHT: (C)2004,JPO
ETHNOPHARMACOLOGY RELEVANCE: Cunila lythrifolia Benth. (Lamiaceae) commonly named "poleo de monte" is a Mexican plant known since pre-Hispanic times because of the properties of its aerial parts to treat respiratory and gastrointestinal conditions, for postpartum care, and as an aphrodisiac.
AIM OF THE STUDY: To obtain preclinical evidence of the pharmacological properties of C. lythrifolia on abdominal pain and some digestive enzymes, as well as its chemical composition.
MATERIAL AND METHODS: The preclinical safety of a decoction was evaluated by the Lorke method in mice. The antinociceptive effect was assessed using the acetic acid-induced writhing test in mice, and the mechanism of action was explored by the co-administration of naloxone. Additionally, the inhibition of the lipase and α-amylase was carried out using a colorimetric assay to calculate the percentage of inhibition. The isolation of specialized metabolites was carried out using chromatographic techniques, and characterization was established with MS, NMR, and chiroptical analysis. The volatile components of the aerial parts were identified by GC-MS analysis of the essential oils, and by HSPM coupled with GC-MS. An analytical method by UHPLC was validated under the guidelines of the ICH, for the quantification of 1.
RESULTS: The LD50 of the aqueous extract is higher than 5 g/kg. The decoction and the essential oil have an antinociceptive effect at 100 and 10 mg/kg, respectively. The essential oil was active against the lipase enzyme (96-76 % of inhibition). The isolated compounds from the decoction were linarin (1), 7-O-[2-O-acetyl-β-D-glucopyranosyl-(1 → 2)-[α-L-rhamnopyranosyl-(1 → 6)]-β-D-glucopyranoside] (2), lithospermic acid (3), rosmarinic acid (4), and citrusin C (5). Compound 1 showed an antinociceptive effect at 316 mg/kg. A UHPLC method was validated for the quantification of 1 in three different batches. The volatiloma analysis revealed that menthofuran (10), β-caryophyllene (22), spathulenol (31), and caryophyllene oxide (32) are the major constituents in the aerial parts. (±)-cunildone (27) a new menthofuran derivative was isolated from the essential oil of the fresh aerial parts.
CONCLUSION: The results of these studies demonstrate the preclinical safety and validate the traditional use of C. lythrifolia as an antinociceptive agent. Contribute to the chemical identification of the species and to the quality control and establish a method for quantitative analysis of the plant. Overall promoting the rational use and quality control of C. lythrifolia.
The present invention relates to a composition for a red ginseng mask pack and a red ginseng mask pack using biocellulose. The composition comprises: refined water; betaine; ginseng extract; red ginseng water; yeast-red ginseng fermented filtrate; hydrolyzed collagen; royal jelly extract; sodium hyaluronate; black bean extract; licorice extract; cimicifuga racemosa root extract; Pleuropterus multiflorus TURCZ. extract; Phellinus linteus extract; Korean angelica extract; morus alba bark extract; paeonia extract; sophora extract; scutellaria extract; lycium extract; biota seed extract; black bean extract; swertia herb extract; an aloe vera leaf extract; and a tangle extract. Intracellular oxidation stress and intracellular melanin synthesis are inhibited, and collagen synthesis and skin moisturizing strength are improved. An allergic reaction may be alleviated. A mask pack according to the present invention is produced by using a biocellulose cloth, so a very excellent effect in improving skin adhesion and skin permeability of several sorts of active ingredients is ensured.
Participants in this group will have pressure monitoring of the anterior compartment of their leg using an indwelling IMP catheter (MY01, MY01 Inc., Montreal, CA). The participants will be treated according to the standard-of-care regarding management of their underlying injury and diagnosis of ACS as practiced by their treating surgeon. Participants will be followed for six months post-injury.
Hematologic neoplasms with germline predisposition have been increasingly recognized as a distinct category of tumors over the last few years. As such, this category was added to the World Health Organization (WHO) 4th edition as well as maintained in the WHO 5th edition and International Consensus Classification (ICC) 2022 classification systems. In practice, these tumors require a high index of suspicion and confirmation by molecular testing. Flow cytometry is a cost-effective diagnostic tool that is routinely performed on peripheral blood and bone marrow samples. In this review, we sought to summarize the current body of research correlating flow cytometric immunophenotype to assess its utility in diagnosis of and clinical decision making in germline hematologic neoplasms. We also illustrate these findings using cases mostly from our own institution. We review some of the more commonly mutated genes, including CEBPA, DDX41, RUNX1, ANKRD26, GATA2, Fanconi anemia, Noonan syndrome, and Down syndrome. We highlight that flow cytometry may have a role in the diagnosis (GATA2, Down syndrome) and screening (CEBPA) of some germline predisposition syndromes, although appears to show nonspecific findings in others (DDX41, RUNX1). In many of the others, such as ANKRD26, Fanconi anemia, and Noonan syndrome, further studies are needed to better understand whether specific flow cytometric patterns are observed. Ultimately, we conclude that further studies such as large case series and organized data pipelines are needed in most germline settings to better understand the flow cytometric immunophenotype of these neoplasms.
The present invention provides a compound represented by the following formula (I) or a salt thereof, which exhibits an inhibitory effect on at least one kinase selected from the group consisting of Akt kinase, Rsk kinase and S6K kinase and/or a cell proliferation inhibitory effect, and is useful as a prophylactic and/or therapeutic agent for the above kinase-associated diseases, particularly cancer. In the formula (I), R 1 Is a four-to six-membered monocyclic unsaturated heterocyclic group which may have a substituent and has 1 to 3 hetero atoms selected from N, S and O; r 2 Hydrogen atom, etc.; r 3 、R 4 And R 5 The same or different are hydrogen atom, etc.; r 6 Hydrogen atom, etc.; r 7 And R 8 The same or different are hydrogen atom, etc.; x 1 And X 2 Identically or differently N or CR 9 ；R 9 Hydrogen atom, etc.; when the dotted line portion (-) is a single bond, X is 3 Is N or CH, when the dotted line part is a double bond, X 3 Is C; wherein, X 1 And X 2 Is N.
Approximately 60% of septic patients developed acute kidney injury (AKI). The mortality rate of septic AKI (SA-AKI) is two to three times higher than that of septic without AKI (SA-non-AKI). The actual functions and mechanisms of CircRNAs in the pathophysiology of SA-AKI remain incompletely understood. Herein, we observed that the mmu_Circ_26986 could be induced by lipopolysaccharide (LPS) and cecum ligation and puncture (CLP) in BUMPT cell line and C57BL/6 mouse kidney, respectively. Functionally, mmu_Circ_26986 suppressed BUMPT cell apoptosis induced by LPS. Mechanistically, mmu_Circ_26986 sponged miRNA-29b-1-5p to upregulate the expression of PAK7. Overexpression of mmu_Circ_26986 ameliorated the progression of CLP-stimulated AKI through miRNA-29b-1-5p/PAK7 axis. In addition, we found that hsa_Circ_0072463, homologous to mmu_Circ_26986, suppressed LPS-induced HK-2 cells apoptosis via regulation of miRNA-29b-1-5p/PAK7 axis. Furthermore, sepsis patients with AKI had a higher level of hsa_Circ_0072463 compared to those without AKI. The sensitivity, specificity and AUC of hsa_Circ_0072463 were 78.8%, 87.9% and 0.866, respectively. Spearman's test indicated a noticeable positive correlation between plasma hsa_Circ_0072463 and serum creatinine in sepsis patients (r = 0.725). In summary, this study reveals that the mmu_Circ_26986/hsa_Circ_0072463 miRNA-29b-1-5p/PAK7 axis mediates septic AKI, and hsa_Circ_0072463 is a potential diagnostic marker for septic AKI.
OBJECTIVES: Persistent postural-perceptual dizziness (PPPD) is a chronic functional vestibular disorder for which the Bárány Society has established diagnostic criteria. This nationwide multicenter study aims to investigate the clinical features of individuals with definite PPPD and clinical variant PPPD who do not fully meet the diagnostic criteria, with a particular focus on visual exaggeration.
METHODS: Between September 2020 and September 2021, a total of 76 individuals with definite PPPD and 109 individuals with clinical variant PPPD who did not meet all three exacerbating factors outlined in Criterion B were recruited from 18 medical centers in South Korea. The study gathered information on demographic factors, clinical manifestations, balance scales, and personality assessments.
RESULTS: Comparative analysis between groups with definite PPPD and clinical variant with visual exacerbation revealed no significant differences in sociodemographic characteristics, clinical course, dizziness impact, and specific precipitants. Only disease duration was significantly longer in definite PPPD compared with variant with visual exacerbation. However, the variant without visual exacerbation displayed significantly reduced rates of panic disorder, diminished space-motion discomfort, lesser impact of dizziness, and decreased prevalence of depression when compared with the definitive PPPD.
CONCLUSION: This is the first comprehensive nationwide study examining clinical features of both definite PPPD patients and its clinical variants, considering visual exacerbating factors. Differences in dizziness and personality traits emerged between definite PPPD and its potential variant without visual issues. Our results highlight the possibility of a distinct clinical variant of PPPD influenced by visual dependency.
The present invention relates to a fast-release as well as a prolonged release type of nifedipine pellets and the process for the preparation thereof. The fast-release type of nifedipine pellets comprises a particulate core which is covered by a nifedipine coating layer. The particulate core comprises water-soluble or water-insoluble excipient(s) and a pharmacologically acceptable carrier. The nifedipine coating layer comprises an effective amount of nifedipine dissolved in organic solvent(s). This nifedipine coating layer can further be mixed with a suspension which comprises an adhesive, an emulsifier, and a dispersant. The preferred composition of the fast-release type of nifedipine includes 20-70% of the particulate core, 3-15% of nifedipine, 1-20% of emulsifier, 1-20% of adhesive, and 1-30% of dispersant. The prolonged-release type of nifedipine pellets comprises, in addition to the particulate core and the nifedipine coating layer, a surface coating layer which is made of at lease one consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose and ethylcellulose. This surface coating layer further comprises a plasticizer which is selected from the group consisting of triethylcitrate, triacetin, and diethyl phthalate.
The safety of Ganirelix Acetate Injection was evaluated in two randomized, parallel-group, multicenter controlled clinical studies. Treatment duration for Ganirelix Acetate ranged from 1 to 14 days. Table IV represents adverse events (AEs) from first day of Ganirelix Acetate administration until confirmation of pregnancy by ultrasound at an incidence of ≥ 1% in Ganirelix Acetate-treated subjects without regard to causality. 

During post-marketing surveillance, rare cases of hypersensitivity reactions, including anaphylaxis (including anaphylactic shock), angioedema and urticaria have been reported with Ganirelix Acetate, as early as with the first dose (see PRECAUTIONS). 

Congenital Anomalies

An observational study in more than 1000 newborns compared the incidence of congenital anomalies in newborns of women administered Ganirelix Acetate to historical controls of a GnRH agonist. This study demonstrated that the incidence of congenital anomalies in children born after COH treatment in women using Ganirelix Acetate was comparable with that reported after a COH treatment cycle using a GnRH agonist. 

The incidence of congenital malformations after some Assisted Reproductive Technologies (ART) [specifically in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI)] may be slightly higher than after spontaneous conception. This slightly higher incidence is thought to be related to differences in parental characteristics (e.g., maternal age, maternal and paternal genetic background, sperm characteristics) and to the higher incidence of multi-fetal gestations after IVF or ICSI. The causal relationship between these congenital anomalies and Ganirelix Acetate Injection is unknown. 

To report SUSPECTED ADVERSE REACTIONS, contact Fresenius Kabi USA, LLC at 1-800-551-7176 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
PURPOSE: This study explores experiences of using beach assistive technology (AT), such as beach wheelchairs, powered wheelchairs, prosthetics and crutches, to participate in sandy beach-based leisure for people with mobility limitations.
METHODS: Online semi-structured interviews were conducted with 14 people, with mobility limitations and experience of using Beach AT. A phenomenological interpretative hermeneutic approach guided reflexive thematic analysis of verbatim transcripts.
FINDINGS: Three overarching themes were identified as: The meaning of using Beach AT, Practicalities of using Beach AT and Responses to using Beach AT. Each overarching theme was underpinned by subthemes. Meaning included: AT connects me, AT impacts my identity and AT attracts attention. Practicalities included: using AT requires other people, AT impacts spontaneity, AT limitations and AT use differs in water. Responses to using Beach AT included: I didn't think it was possible, adaptions to AT limitations and not everyone wants to own Beach AT.
CONCLUSION: This study illustrates the use of Beach AT as a facilitator for beach leisure, enabling connections to social groups and contributing to one's identity as a beachgoer. Access to Beach AT is meaningful and may be made possible through personal Beach AT ownership or access to loaned AT. The unique nature of sand, water, and salt environments requires users to identify how they plan to use the devices, with realistic expectations that the Beach AT may not enable full independence. The study acknowledges the challenges related to size, storage, and propulsion, but emphasizes that these can be overcome through ingenuity.
A method for synthesizing calcium-silicate-based porous particles (CSPPs) is described. Control over CSPP morphology and pore size is achieved through a refined solution-based synthesis, allowing loading of a variety of sealants. These particles, upon external stimuli, release the loaded sealant into the surrounding material. Methods of loading the CSPPs with loading sealant are described. The CSPPs may be used in pure form or mixed with another material to deliver self-healing, sealing and multi-functional properties to a physical structure. The composition of the CSPPs is described, along with methods of use of the CSPPs.
Group 2 will receive standard perioperative pain management for TKR; will undergo placebo femoral nerve block under ultrasound guidance with normal saline (NS) 20 cc. Following femoral bone cuts they will receive local anesthetic injection mixture of 30cc 0.25% bupivicaine with epinephrine 20 cc of preservative free normal saline, 30mg of toradol and 10 mg of morphine sulfate into the periarticular tissues including periosteum, joint capsule and posterior capsule of the knee joint and collateral ligaments and subcutaneous tissues. Prior to cementing prosthesis, a second injection with mixture of 20mL 1.3% Exparel and 40mL normal saline solution will be injected into the same tissues, joint capsules and collateral ligaments.
Participants will be shown 3 frozen meals at once; each product will be high in 1, 2, or 3 nutrients of concern (added sugar, sodium, and/or saturated fat) and will be labeled as such with a rectangular "high in" front-of-package label. The label will contain "high in" and nutrient text, along with an exclamation mark icon.
Patients will receive standard concussion management, but will be asked to exercise on a stationary bike on two different occasions (once for 15 minutes and again for 30 minutes) in their first week of recovery. This group will also be asked to complete a 30 minute leisurely walk at their convenience on the two days they are not tested at UBC or Fortius.
PURPOSE:To obtain a bathing agent, capable of softening hot water, providing good warming effects and maintaining beautiful skin, usable throughout the four seasons and having high effects, by blending rice bran as a principal raw material with 'BAIEMU KOSO' (enzyme), 'BAIMU' food, sugar and perfume. CONSTITUTION:Rice bran is roasted and then mixed and stirred with 'BAIMU' food. 'BAIEMU KOSO' (enzyme) and sugar are dissolved in warm water and then blended with the rice bran mixed with the 'BAIMU' food, further stirred and fermented. Stirring is carried out when fermentation is started by generation of heat while feeding oxygen. A perfume is subsequently added when the fermentation is completed and the resultant blend is dried to afford the aimed substance. Although the rice bran is not conventionally used as a bathing agent, it becomes a beauty element of the skin by action thereof. Since the enzyme is blended, fatty dirt is removed and the residual hot water is more effective in using for washing and sprinkling than that of only water.
The present technology refers to mesh materials for the controlled release of antimicrobial and antiviral compounds, with high antiviral activity and efficiency, mainly against the coronavirus. It also refers to the process for producing mesh materials with bis-biguanide:cyclodextrin inclusion compounds in molar ratios in the range of 1:1 to 1:4. The mesh materials are selected from the group consisting of polymers, fibers, non-woven fabric (NWF), fabrics, paper, cellulose, alone or in combination, or a combination of one or more of these mesh materials with adhesives. Mesh materials impregnated, extruded, saturated, coated or laminated with bis-biguanide:cyclodextrin inclusion compounds have been shown to be effective in inactivating/destroying viral particles. In fabrics, the inclusion compounds showed virucidal activity for all viruses of the coronavirus group for a contact time from 2 minutes, having its effect prolonged for a period greater than 30 days. Mesh materials for controlled release of antivirals showed activity up to 1,000 times more effective compared to the use of non-encapsulated chlorhexidine.
The invention relates to a traditional Chinese medicine composition, and specifically relates to a traditional Chinese medicine composition used for treating kidney stone, and an application thereof. The traditional Chinese medicine composition is composed of the components of: 18-25f of christina loosestrife herb, 15-20g of white peony root, 15-20g of Japanese climbing fern spore, 10-15g of cluster mallow fruit, 10-15g of Japanese felt fern, 10-15g of fringed pind herb, 15-20f of talc, 10-15g of combined spicebush root, 10-15g of twotoothed achyranthes root, 10-15g of pumice stone, 10-15g of turtle shell, and 4-6g of largehead atractylodes rhizome. The components of the medicine composition are relatively simple and easy to obtain. The medicine composition is safe and reliable, and has clear treatment effect and low cost. Enema administration is adopted, such that the medicine composition can directly reach a lesion site. Therefore, the treatment effect is faster, and side effects are fewer.
Quality assessment organizations leverage numerous patient safety measures to evaluate hospital performance, resulting in significant financial, administrative, and operational burdens on health systems. Low-intensity approaches that allow for reliable risk stratification of patients can reduce the required investment. The Braden score is a routinely performed bedside nursing evaluation validated to assess risk for hospital-acquired pressure injury. We hypothesized that the tool can be used to evaluate risk for other hospital-related adverse outcomes, including mortality, catheter-associated urinary tract infection (CAUTI), and central line-associated bloodstream infection (CLABSI). We found that abnormal Braden scores have significant association with numerous adverse outcome measures, including mortality, CLABSI, CAUTI, and iatrogenic hypoglycemia. Because of its frequency of reevaluation, we have found preliminary evidence that leveraging this tool can reduce harm by quickly identifying the most at-risk patients for various types of iatrogenic harm. We conclude that in the face of increasing automation and technical applications, for example, artificial intelligence-driven tools, highly reliable clinician bedside physical examination and evaluation can still have significant, low-cost, and high-value impact in improving patient safety.