anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Pregnancy is associated with an increased risk of pulmonary aspiration during general anaesthesia, but the incidence of this complication is not well defined.
METHODS: We performed a retrospective database review in a tertiary care university hospital to determine the incidence of pulmonary aspiration in pregnant patients undergoing endotracheal intubation, with and without Rapid Sequence Induction (RSI), as well as face-mask ventilation and supraglottic airway devices. We included Patients in the 2nd or 3rd trimester of pregnancy and immediate postpartum undergoing surgical procedures. The primary endpoint was the occurrence of pulmonary aspiration.
RESULTS: Data from 2,390 patients undergoing general anaesthesia for cerclage of cervix uteri, manual removal of retained placenta, repair of obstetric laceration, or postpartum bleeding were retrospectively evaluated. A supraglottic airway device or face-mask ventilation was used in 1,425/2,390 (60%) of patients, while 638/2,390 (27%) were intubated. RSI was used in 522/638 (82%) of patients undergoing tracheal intubation, or 522/2,390 (22%) of the entire cohort. In-depth review of the charts, including 54 patients who had been initially classified as "possible pulmonary aspiration" by anaesthetists, revealed that this adverse event did not occur in the cohort.
CONCLUSIONS: In conclusion, in this obstetric surgery patient population at risk for pulmonary aspiration, supraglottic airway devices were used in approximately 60% of cases. Yet, no aspiration event was detected with either a supraglottic airway or endotracheal intubation.
PROBLEM TO BE SOLVED: To obtain a new chalcone derivative useful for an antiallergic agent having an excellent cis-leukotriene receptor antagonistic action. SOLUTION: This derivative is expressed in formula I (A is phenyl, quinolyl, etc., W is vinylene, etc.,; R<1> to R<5> are each a carboxyl, cyano, an alkyloxycarbonyl, etc.) and its salts, e.g. 4(2-quinolylmethoxy)-benzaldehyde. The compound of formula I is obtained by carrying out a reaction of an aldehyde of formula II and an acetophenone of formula III in a solvent such as methanol, etc., in the presence of a base such as NaOH or KOH, etc. The compound is useful for prevention and medical treatment of asthma, allergic rhinitis, dermatitis allergica, allergic inflammation of the conjunctiva, erythema urticatum, trichophytosis, rheumatism, inflammatory colitis, cerebral ischemia, apoplexia cerabri, etc. The daily dose is 1 to 1,000mg/adult administered in one to several times of oral dosing or parenteral dosing.
The Melillo et al. article: Reliability and validity of the Veterans Administration Mobility Screening and Solutions Tool (MSST) (Melillo et al, BMC Health Serv Res 22:1323, 2022) introduces the MSST, a derivative flowchart tool in which the Banner Bedside Mobility Assessment Tool (BMAT) is embedded. The authors identify similar goals for the MSST as those for the BMAT, i.e. determine real-time mobility status and choose safe patient handling and mobility (SPHM) equipment to complete transfer and mobility tasks. Further Melillo et al. indicate that goals included "revising and enhancing" and addressing "gaps" in the BMAT, as well as creating instructions for the four BMAT levels (sit and shake, stretch and point, stand, step: march-in-place, advance step and return) that are clear, understandable and comfortable to use. The authors indicate that another goal of the VA MSST is it "enables any healthcare worker at any time to accurately measure and communicate patient mobility and transfer equipment needs." The present article addresses inaccuracies observed in the Melillo et al. article and confusing elements found in the VA MSST flowchart. The present article is based on the author's involvement in developing the BMAT starting in 2003 along with teams from Banner Health and Liko/Hill-Rom which incorporated use of the BMAT by unlicensed assistive personnel (UAP) as a recheck or verification of earlier testing. The 2020 BMAT 2.0 clarified confusing elements identified in BMAT 1.0, i.e. items that needed to be revised or enhanced. BMAT 2.0 covered use of SPHM when testing, when completing care tasks and when progressing patients. The BMAT is primarily a nurse-driven mobility assessment tool created to not be overly prescriptive. BMAT was validated and determined to be reliable based on years of clinical utility studies and research in various settings across the continuum of care. It continues to be supported by a large medical equipment manufacturer who maintains the copyright license. Although the VA MSST flowchart has the four BMAT assessment levels embedded within it, for reasons outlined in this article, it is not feasible to use the VA MSST flowchart alongside or in conjunction with the BMAT 2.0.
OBJECTIVE: Patients with type IIA craniofacial microsomia (CFM) may benefit from mandibular distraction osteogenesis (MDO) treatment during childhood; however, remodelling of the mandible during the consolidation phase, which may affect the short-term outcomes of MDO, has not yet been quantitatively analysed using computed tomography. Therefore, we aimed to investigate bone remodelling of the mandible in children with type IIA CFM treated with MDO before distractor removal and the factors that influence ramus vertical elongation efficiency.
MATERIALS AND METHODS: Twenty-three children with unilateral CFM were studied between 2020 and 2024. Longitudinal computed tomography data (preoperative, end of active phase and at pre-distractor removal) were analysed. Condyle positions and the mandibular cant were analysed using a paired-sample t test. The relapse rates of vertical lengthening and mandibular cant were calculated. The correlation between distraction efficiency and preoperative craniofacial morphology was analysed.
RESULTS: The condyle on the affected side moved upwards and backwards by 28.84 ± 4.08 and 2.85 ± 4.33 mm, respectively during the active phase but lost 7.66 ± 2.64 mm of vertical extension during the consolidation phase. The relapse rates for vertical extension of the condyle and occlusal plane were 27% and 35%, respectively. The ratio of mandibular ramus height was positively related to EV.
CONCLUSIONS: In children with CFM, attention should be paid to vertical elongation instability and relapse of mandibular inclination during consolidation. Severe mandibular ramus hypoplasia is a preoperative risk factor for vertical skeletal relapse during consolidation. Further efforts are required to reduce the stress that leads to relapse.
Healthy individuals will participate in two separate days of cardiopulmonary exercise testing (CPET) (separated by a minimum of two, maximum of 7 days apart) prior to starting the aerobic exercise training program (AET). Individuals will then complete a 4-5 week (4x/week x 17 sessions) continuous, high-intensity AET. Each training session will consist of cycling for 3-5 minutes to warm-up, 45 minutes at 70% of heart rate reserve (HRR-determined from pre-training CPET), and 5-10 minutes to cool down. Following the AET, individuals will repeat the two separate days of CPET performed pre-training.
Physical activity can worsen migraine, leading to reduced activity levels in adults with chronic migraine. This study investigated the change in average steps per day, as a surrogate marker of physical activity, in adults with chronic migraine successfully treated with monoclonal antibodies against calcitonin gene-related peptide or its receptor. Data were obtained from adults with chronic migraine, who were classified as responders to preventive treatment with monoclonal antibodies. The primary endpoint was the difference in a mean number of steps per day between the 3 months prior to treatment initiation and the first 3 months after treatment initiation. The secondary endpoint was the correlation between the change in steps per day and the change in monthly migraine days. Twenty-two (20 females) participants with a median age of 48.5 years were enrolled. The median number of steps per day increased from 4421 at baseline to 5241 after treatment (P = 0.039). We found a positive correlation between the increase in steps per day and the treatment response (P = 0.013). In conclusion, an increase in physical activity, based on steps per day, positively correlated with treatment response to monoclonal antibodies. Automatically registered daily step count data might be used to monitor physical activity as a response to preventive treatment in adults with chronic migraine.
This group did not undergo training in the breathing technique and use of the PSMD during the RTC trial day 0-28, but were visited twice weekly by the research team to collect outcome data. During the trial extension Day 28-56, this group did undergo a 1 hr training session with the PSMD and invited to use it at their discretion over the 28 days. Effectiveness outcome data (day 28-56) was collected at day 56.
Balloon pulmonary angioplasty. Typically 4-8 sessions are needed to treat the patient. The specific pre-planning protocol, choice of wires and balloons, the number of vessels treated per session, and the decision that no further BPA sessions are needed is at the discretion of the treating physician.
PURPOSE: Genetic variants of AMELX gene can affect the protein content, organization of enamel prisms, microstructure and microhardness of the enamel, thus altering the caries susceptibility. The present study aims to assess the association between polymorphisms rs17878486, rs5934997, and rs5933871 of AMELX gene and Early Childhood Caries (ECC).
MATERIALS AND METHODS: This case-control study was conducted on 200 participants, aged 3-6 years, with 100 controls and 100 children with ECC. A questionnaire was used to collect demographic data, birth-weight, type of delivery, oral hygiene practices, feeding history and 24-h diet diary. DNA was isolated from blood and subjected to PCR followed by Sanger sequencing.
RESULTS: The CC genotype of rs17878486 showed an OR of 1.93 (0.34-10.81; P = 0.73). In a recessive model, the CC genotype of rs17878486 reported an OR of 2.04 (0.36-11.40; P = 0.68); rs5593871 reported an OR of 1.00 (0.31-3.21). Statistically significant differences (P ≤ 0.05) between genotype and allele frequencies of rs17878486, rs5934997, and rs5933871 were not observed between children with ECC and the controls.
CONCLUSION: Polymorphisms of AMELX gene did not show a significant association with ECC in this population. However, documentation of genetic data in a global context of ECC may be essential for the future.
In this arm, after establishing TIMI -3 flow in infarct related artery with balloon angioplasty, patients will undergo stent implantation when coronary autoregulatory function was recovered (initial hyperemic flow was subsided and baseline resistance was increased). Recovery of the auto regulatory function will be determined by measuring microvascular flow and resistance. After stenting microvascular flow / resistance will continue to be monitored using pressure/flow sensor tipped guide wire until the completion of 1 hour follow up period.
It will be a randomized, controlled, double-blind, single-center clinical trial conducted in the Intensive Care Unit (ICU) of the State Hospital of Serrana (HE Serrana). Patients admitted to the ICU who meet the eligibility criteria and have given written informed consent will be randomized into control and intervention groups. Forty-seven patients will be included in each group, totaling 94 patients. The intervention group will receive 200 mg of testosterone cypionate intramuscularly every 5 days for a total of 3 doses. The control group will receive a placebo on the same schedule. After inclusion in the study, demographic and clinical data, laboratory results, ultrasonographic measurements, and functionality and muscle strength scores will be assessed on days 1, 5, 10, and 15 in the ICU and until hospital discharge.
OBJECTIVES: Giant cell granuloma is a local nonneoplastic lesion that is divided into two categories, based on its site of occurrence: Central and peripheral giant cell granuloma. Central giant cell granuloma is an intraosseous lesion that has a tendency to recure even in surgically treated cases. Several studies have proven that there is an association between different lesions clinical behavior and their histological features. The aim of this study was to evaluate the expression of AgNOR and Ki67 in lesions with and without recurrency.
MATERIAL AND METHODS: Files and records of 35 patients who had been histologically diagnosed with central giant cell granuloma were investigated. Histological features were studied after performing AgNOR staining and Ki67 marker. The data were analyzed by chi-square, Fisher, and T-test.
RESULTS: Acquired data indicated that the count of AgNOR staining and Ki67 marker was significantly higher in lesions with recurrency than the lesions with no recurrency. The same results were attained from Ki67 intensity.
CONCLUSION: The current study indicated that AgNOR staining and Ki67 marker have prognostic value in predicting recurrency of central giant cell granuloma lesions.
The hypothesis of this study is that customary doses of antibiotics, when administered for perioperative surgical prophylaxis, are insufficient to achieve adequate antibiotic concentrations in blood and tissues of morbidly obese patients (defined as a BMI greater than 40 kg/m2) and that these patients are therefore placed at high risk of surgical wound infections and poor clinical outcomes. Cefazolin is a first-generation cephalosporin commonly used for perioperative surgical prophylaxis in colorectal, abdominal, bariatric, gynecologic and obstetric, or orthopedic total joint arthroplasty surgical procedures. Previous cefazolin pharmacokinetic (PK) analysis in obese patients led to conflicting results and recommendations. It is not clearly know to what extent the pharmacokinetics of cefazolin in morbidly obese patients differ from those of non-obese patients. Specific dosing guidelines are then lacking. The main objective of this study is to assess the pharmacokinetics of cefazolin in morbidly obese after administrations of a standard recommended 2-3 g dose or a weight-base 30-mg/kg dose
<P>PROBLEM TO BE SOLVED: To provide a skin-lightening cosmetic exhibiting excellent bleaching effects and originated from a natural product.  <P>SOLUTION: Arenaria kansuensis Maxim. is a perennial small herb mainly distributed in China such as Tibet, Gansu, Qinghai and the western part of Sichuan, and grows in a crack of a stone in a high mountain of limestone or in meadow. The bleaching cosmetic is obtained by newly discovering that an extract of the Arenaria kansuensis Maxim. has melanin formation-inhibiting effects, and the cosmetic formulated with the Arenaria kansuensis Maxim. has the excellent bleaching effects although there is an example of the extract of the Arenaria kansuensis Maxim. formulated in an external preparation for the skin as a humectant.  <P>COPYRIGHT: (C)2009,JPO&INPIT
Cosmetic compositions for application to the skin, e.g. a cleansing or nutritive cream comprise fatty or waxy substances of the type commonly used therein and, in addition to the other conventional ingredients, "sucroglycerides," i.e. products obtainable by the transesterification of sucrose with a natural triglyceride or with a lower alkyl ester of a 'C6-30 fatty acid or mixtures thereof. Sucrose esters, e.g. with fatty acids, may also be present. Specifications 824,654 and 912,595 are referred to.
In the Aquarium VR group, virtual reality headset compatible with iPhone 7 (Apple) was used to distract attention. Before use, the headsets were tested on five children for face fit and visibility of the application used. Written and verbal consent of the children and their parents was obtained to test the headsets. The children who tested the headsets were not included into the study. The headset offered a soft and comfortable experience in contact with the skin due to its leather and pad covering. It also had a wide viewing angle and an optical zoom button. Due to its noise isolation function, it did not disturb anyone or make noise.
An electrical patch and associated system for acquisition of physiological data is described. The patch has a design that enables a variety of configurations depending upon the requirements physiological measurements to be made. Patches with single input channels to patches with multiple input channels, processing capabilities and radio communication can all use the same physical configuration. The design includes a battery management system to enable long term data acquisition and an optimization process that includes mirroring of algorithms on the patch and devices local to the user with algorithms running on a centrally located server. The server can then optimize data acquisition and analysis algorithms. The components of the system and methods of use are included.
The long-term goal for this project is to establish a model of alcohol seeking despite aversion (SDA) as a platform for the laboratory testing of novel pharmacologic and behavioral interventions that can be used among those with the highest risk, but who have yet to progress to treatment-resistant drinking. The objective of this application is to test SDA across multiple levels of analysis. The investigators consider SDA as an early marker of alcohol use disorder progression that is related to lifetime drinking history, alcohol use disorder risks, and brain physiology. The investigators have completed a pilot study demonstrating that SDA can be objectively quantified via an intravenous alcohol self-administration task, in which operant work for identical incremental alcohol rewards is paired with aversive stimuli. This preliminary data supports the central hypotheses that behavior in the SDA model is attributable to lifetime alcohol exposure, is related to alcohol use disorder risk factors and phenotypes, and reflects alterations in neural system function. In this project, SDA will be measured along with recent drinking history, negative affect-based rash action (i.e. negative urgency, including action with respect to alcohol use), and self-rating of the effects of alcohol. The rationale for this work is that it would lead to the first objective, well-validated measure of SDA in humans.
PURPOSE: This study aims to determine the effect of a telehealth intervention for SLE patients on pain, happiness, and life activities.
METHODS: The study was conducted as a randomized controlled study. The sample of the study consisted of a total of 73 participants, including the experimental group (n = 37) and the control group (n = 36). Random number generation using Excel was used to determine how subjects were randomly assigned to treatment and control groups. Numerical Rating Scale, Oxford Happiness Scale Short Form, and Life Activities Scale were used to collect data. In addition to their routine treatments, participants in the experimental group received telehealth intervention once a week for 12 weeks, each intervention lasting 15 to 20 minutes. No application was made to the control group during the intervention. Scales were applied to both groups at the beginning of the study, in the 6th week, and in the 12th week.
RESULTS: Pain scores of the experimental group were lower at the 6th and 12th weeks compared to the beginning. While there was no difference in pain comparison between the groups at the 6th and 12th weeks, the pain score of the experimental group at the 12th week was significantly lower than the control group. It was determined that the happiness scale scores in the experimental group were higher at the 6th and 12th weeks compared to the beginning. At the end of the 12th week, the happiness score of the experimental group was higher than the control group. It was determined that the life activities scores in the experimental group were higher at the 6th and 12th weeks compared to the beginning.
CONCLUSION: It has been determined that telehealth application has a positive effect on the pain, happiness, and life activities of SLE participants. We suggest that future research should be conducted to improve the body image of SLE participants.
15 voluntary children with receiving palliative care, aged between 1-3 years will be randomly divided into two groups: fairy tale group and cartoon group. Interventions will be applied for 3 weeks, 1 times a day (16 sessions). No intervention will be applied to both groups besides fairy tale or cartoon intervention. The children will be assessed before, during and after. PAIN DUE TO ASPIRATION PROCEDURE will be evaluated using the FLACC Pain Scale. In addition, the heart rate, respiration, blood pressure, tidal volume and fever values of the children will be measured with the help of a bedside monitor.
BACKGROUND: Echocardiographic studies indicate South Asian people have smaller ventricular volumes, lower mass and more concentric remodelling than White European people, but there are no data using cardiac MRI (CMR). We aimed to compare CMR quantified cardiac structure and function in White European and South Asian people.
METHODS: Healthy White European and South Asian participants in the UK Biobank Imaging CMR sub-study were identified by excluding those with a history of cardiovascular disease, hypertension, obesity or diabetes. Ethnic groups were matched by age and sex. Cardiac volumes, mass and feature tracking strain were compared.
RESULTS: 121 matched pairs (77 male/44 female, mean age 58 ± 8 years) of South Asian and White European participants were included. South Asian males and females had smaller absolute but not indexed left ventricular (LV) volumes, and smaller absolute and indexed right ventricular volumes, with lower absolute and indexed LV mass and lower LV mass:volume than White European participants. Although there were no differences in ventricular or atrial ejection fractions, LV global longitudinal strain was higher in South Asian females than White European females but not males, and global circumferential strain was higher in both male and South Asian females than White European females. Peak early diastolic strain rates were higher in South Asian versus White European males, but not different between South Asian and White European females.
CONCLUSIONS: Contrary to echocardiographic studies, South Asian participants in the UK Biobank study had less concentric remodelling and higher global circumferential strain than White European subjects. These findings emphasise the importance of sex- and ethnic- specific normal ranges for cardiac volumes and function.
The administration of painful primes has been shown to influence the perception of successively presented semantic stimuli. Painful primes lead to more negative valence ratings of pain-related, negative, and positive words than no prime. This effect was greater for pain-related than negative words. The identities of this effect's neural correlates remain unknown. In this EEG experiment, 48 healthy subjects received noxious electrical stimuli of moderate intensity. During this priming, they were presented with adjectives of variable valence (pain-related, negative, positive, and neutral). The triggered event-related potentials were analyzed during N1 (120-180 ms), P2 (170-260 ms), P3 (300-350 ms), N400 (370-550 ms), and two late positive complex components (LPC1 [650-750 ms] and LPC2 [750-1000 ms]). Larger event-related potentials were found for negative and pain-related words compared to positive words in later components (N400, LPC1, and LPC2), mainly in the frontal regions. Early components (N1, P2) were less affected by the word category but were by the prime condition (N1 amplitude was smaller with than without painful stimulation, P2 amplitude was larger with than without painful stimulation). Later components (LPC1, LPC2) were not affected by the prime condition. An interaction effect involving prime and word category was found on the behavioral level but not the electrophysiological level. This finding indicates that the interaction effect does not directly translate from the behavioral to the electrophysiological level. Possible reasons for this discrepancy are discussed.