anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Participants initiating concomitant TLD and RIF-containing TB treatment, with an additional daily dose of dolutegravir (DTG) 50mg. For participants already on RIF-containing TB treatment when TLD treatment is started, TLD treatment must be started within 8 weeks (56 days) of the start of RIF-containing TB treatment. Group 1, 2, or 4 participants who start RIF-containing TB treatment after enrollment will have additional evaluations at the start and end of concomitant HIV and TB treatment but will not be co-enrolled in Group 3 (their additional evaluations will, however, be considered when analyzing data from Group 3).
The invention relates to the field of cosmetics, and particularly relates to a whitening and freckle-removing essence and a preparation method thereof. The whitening and freckle-removing essence mainly comprises the following components: l-vitamin C, tea extract, licoflavone, ginkgo leaf extract, trehalose, xanthan gum and citric acid. The content of the tea extract and the ginkgo leaf extract is not zero at the same time. The L-vitamin C content is not less than 99.5%, and the content of Glycyrrhiza glabra extract in licoflavone aqueous solution is 0.5% -5%. The levorotatory vitamin C in the whitening and freckle removing essence is a well-known whitening and antioxidant component, can well permeate the skin, inhibits and removes free radicals, can moisturize and moisturize, and maintains light skin moisture. Licoflavone can effectively inhibit tyrosinase from synthesizing melanin, enhance skin hydration degree, and nourish skin. Research shows that the levorotatory vitamin C, the licoflavone and the like have the capacity of obviously inhibiting and removing free radicals and realize the effects of whitening the skin and removing freckles.
BACKGROUND: Common postoperative complications following surgery, particularly acute appendicitis surgery, include postoperative pain and vomiting, which can cause discomfort and delay recovery time.
METHODS: A randomized double-blinded placebo-controlled clinical trial was conducted with 80 cases of acute appendicitis of American Society of Anesthesiologists (ASA) physical status I or II and aged 18-60 y/o scheduled for appendectomy under general anesthesia. Patients were randomly divided into two equal groups: group A received 4 mg of ondansetron IV (2 ml) and group B received 2 ml of normal slain IV (placebo). Pain according to VAS, nausea and vomiting according to clinical symptoms, shivering and sedation according to the Bedside Shivering Assessment Scale (BSAS), and the Ramsay Sedation Scale (RSS) at 2, 6, 12, and 24 hours after surgery were evaluated and compared between the groups.
RESULTS: There was a significant decline in the severity of pain only at 2 hours after surgery between the ondansetron and control groups (5.3 ± 1.0 vs. 6.0 ± 1.0; p=0.01), not showing a difference between the groups at 6, 12, and 24 hours after appendectomy. Postoperative nausea and vomiting at 2 (5% vs. 25%; p=0.03) and 6 (7.5% vs. 27.5%; p=0.04) hours after appendectomy in the ondansetron group. At different times, the ondansetron and control groups did not differ in terms of pethidine consumption or sedation.
CONCLUSIONS: In conclusion, our study found that ondansetron was effective in reducing postoperative vomiting after acute appendicitis surgery. However, it did not show a clinically significant effect on postoperative pain. This trial is registered with IRCT20230722058883N1.
OBJECTIVE: Previous studies have reported sex differences in non-alcoholic fatty liver disease (NAFLD) among adults; however, little is known about its occurrence in children and adolescents. This study aims to examine the prevalence of NAFLD among them and investigate the relationship between sex hormones and NAFLD.
METHOD: This study included 2999 obese Chinese children aged 2-18 years. We examined the prevalence of NAFLD by sex, age, and Tanner stage. The regression model and principal component analysis were used to analyze the relationship between sex hormones and NAFLD.
RESULTS: The prevalence of NAFLD increased with age in both sexes, and the gender difference appeared before puberty. The prevalence in boys tended to stabilize at the age of 11 years, whereas girls reached their peak temporarily. NAFLD prevalence was positively associated with estradiol in boys (p = 0.011), but the opposite trend was observed in girls (p = 0.031). Testosterone levels decreased with the increase of NAFLD prevalence in boys (p < 0.001). Luteinizing hormone and prolactin were inversely associated with NAFLD prevalence in boys and girls, respectively. Results from the principal component analysis showed that sex hormone levels and fat distribution were important risk factors for the prevalence of NAFLD in obese children (p < 0.001).
CONCLUSION: The significant difference in NAFLD prevalence between genders in obese children begins in early childhood. This distinction emerges long before puberty onset and tends to stabilize during late adolescence. Sex hormones are associated with NAFLD prevalence and are influenced by the Tanner stages and fat distribution.
This study is a self-controlled clinical trial conducted at the Department of Cardiology, Beijing Anzhen Hospital affiliated with Capital Medical University. Eligible patients admitted to the hospital for AF will be enrolled. After obtaining written informed consent from the participants, participants will be instructed to wear both a "single-lead ECG patch" and a smartwatch with PPG. ECG and PPG data will be collected continuously during hospitalization. The collected PPG data will be analyzed automatically using the analysis software provided by Xinjikang Co,. Ltd. The results will then be compared with the cardiologist-annotated ECG results, to investigate the differences between the PPG data and ECG data in identifying AF and estimation of AF burden.
This cross-sectional study examined sleep disturbance associations between parents and their school-age children with overweight and obesity. A 7-day wrist-worn actigraph recording was performed on 246 children aged 6-9 years with overweight and obesity recruited from 10 public elementary schools in Taipei, Taiwan. Children's sleep disturbance was assessed using the Children's Sleep Habits Questionnaire. Parental subjective sleep quality was assessed using the Pittsburgh Sleep Quality Index, with parental depressive symptoms measured using the Epidemiologic Studies-Depression Scale. General linear models were used to examine sleep disturbance associations within parent-child dyads. The results showed that 208 (84.6%) children had a clinically significant sleep disturbance score, and 123 (50%) parents had poor sleep quality. Higher children's sleep disturbance scores significantly predicted poorer parental sleep quality (b = 0.11, p < 0.001). Poorer parental sleep quality was associated with more severe sleep disturbances in children (b = 0.46, p < 0.001). This association was independent of children's actigraphic sleep (all p > 0.05) and was not attenuated by adjustment for parental depressive symptoms (b = 0.14, p < 0.001). Findings from our study suggest that sleep disturbances occur in both parents and their school-age children with overweight and obesity, with a significant bidirectional association between the two. Nurses and healthcare professionals should proactively assess and screen for sleep disturbances in parent-child dyads of children with overweight and obesity. Future studies should develop family-based sleep interventions and evaluate their effects on the sleep, health, and well-being of children with overweight and obesity and their parents.
As a part of this research study the patient and caregiver will undergo randomization, "like flipping a coin", to assign the patient and caregiver to one of two research study groups. The patient and the partnered caregiver will join the same group. The group will either receive: 1) three in-person assessments on symptoms and behaviors that the patient may experience and a mobile application that will send surveys to the caregiver in order to rate the presence, severity and stress caused by these symptoms and behaviors; or 2) three in-person assessments on symptoms and behaviors that the patient may experience and no mobile application. The outcomes of these surveys and assessments will then be shared with the patient's clinical team.

If the caregiver is assigned to the group that receives the mobile application they will receive the surveys either weekly or monthly. After each month of completing the surveys, the frequency will change. Depending on feedback from the first 10 participants, the investigators may modify the survey rate to happen more than weekly.
A computer device obtains a to-be-annotated image having a first magnification. The device obtains an annotated image from an annotated image set, the annotated image distinct from the to-be-annotated image and having a second magnification that is distinct from with the first magnification. The annotated image set includes at least one annotated image. The device matches the to-be-annotated image with the annotated image to obtain an affine transformation matrix, and generates annotation information of the to-be-annotated image according to the affine transformation matrix and the annotated image. In this way, annotations corresponding to images at different magnifications may be migrated. For example, the annotations may be migrated from the low-magnification images to the high-magnification images, thereby reducing the manual annotation amount and avoiding repeated annotations, and further improving annotation efficiency and reducing labor costs.
Glycosaminoglycans (GAGs) and proteoglycans (PGs) are essential components of the extracellular matrix (ECM) with pivotal roles in cellular mechanosensing pathways. GAGs, such as heparan sulfate (HS) and chondroitin sulfate (CS), interact with various cell surface receptors, including integrins and receptor tyrosine kinases, to modulate cellular responses to mechanical stimuli. PGs, comprising a core protein with covalently attached GAG chains, serve as dynamic regulators of tissue mechanics and cell behavior, thereby playing a crucial role in maintaining tissue homeostasis. Dysregulation of GAG/PG-mediated mechanosensing pathways is implicated in numerous pathological conditions, including cancer and inflammation. Understanding the intricate mechanisms by which GAGs and PGs modulate cellular responses to mechanical forces holds promise for developing novel therapeutic strategies targeting mechanotransduction pathways in disease. This comprehensive overview underscores the importance of GAGs and PGs as key mediators of mechanosensing in maintaining tissue homeostasis and their potential as therapeutic targets for mitigating mechano-driven pathologies, focusing on cancer and inflammation.
Prodn. of a compsn. for preventing viral haemorrhagic septicaemia (VHS) of trout comprises first culturing the virus on fish cells, then inactivating it totally with beta-propiolactone (I). The virus used is pref. cultured on the EPC (epithelium papulosum cyprini) cell line to a titre of 104-109, esp. 5x107 to 5x108, plaque- forming units per ml. After deactivation with (I) the safety of the prepn. is pref. tested by 2 cultures on fish cell lines, and then opt. further treated with aq. HCHO to a final HCHO concn. of 0.05%. The vaccine protects trout again VHS more conveniently than the rigorous disinfection procedures normally used, and long-lasting protection is afforded.
PROBLEM TO BE SOLVED: To provide an easily usable and highly functional portable information terminal and body fat ratio measuring method by adding the body fate ratio measuring function to a PIM function of the portable information terminal, and commonly using the telephone function, large memory capacity and display screen of the portable information terminal. SOLUTION: Fig. 1 is a block view showing the structure of this portable information terminal with measuring function. The portable information terminal with measuring function roughly comprises a transmission and receipt control part (hereinafter referred to as PDC part for short) 1, an information processing part (hereinafter referred to as PIU part) 16, and a control UART 17. The PDC part 1 is provided with a radio module 2, an analog base band part 3, and a CPU (second CPU) 4, and the PIU part 16 is provided with a cpu (first CPU) 8, a ram 9, a rom 10, a Nandrom 11, a key board 12, a body fat ratio detection part 13, a G/A 14, an LDC (display part) 15. The UART 17 controls the PDC part 1 and the PIU part 16 to exchange the information possessed by each part.
BACKGROUND: To study whether laparoscopic hysteropectopexy (LHP) can be substituted for vaginal hysterectomy (VH) in patients with pelvic organ prolapse (POP), we compared VH with the relatively new procedure, LHP.
METHODS: This retrospective study included 176 women who underwent LHP (N.=54) or VH (N.=122) for a Pelvic Organ Prolapse Quantification (POP-Q) System stage 2 or higher pelvic organ prolapse between January 2011 and December 2019. We compared the surgical outcomes and overall rate of complications between the two groups.
RESULTS: The average length of hospitalization was 5.28 days for the LHP group and 7.08 days for the VH group. EBL (mL) in the LHP group was 32.2, whereas it was 47.7 in the VH group. The average operation time (min) was 68.2 in the LHP group and 98.9 in the VH group. Twenty-seven patients (22.1%) in the VH group had postoperative voiding difficulty compared with 2 patients (3.7%) in the LHP group. The overall number of intraoperative complications was 6 (11%) in the LHP group and 34 (27.9%) in the VH group.
CONCLUSIONS: This study demonstrated that LHP is more effective than VH in patients with POP. However, since the number of cases was small and retrospective studies are limited, we recommend a randomized controlled trial to be conducted in the future to confirm our results.
Participants randomized to the intervention will receive a link to the online intervention following baseline completion. The online and Text Message intervention, and its delivery, will be designed and adapted based on the results of the formative focus groups and cognitive interviews and is meant to be non-confrontational in tone, seeks to increase motivation to increase the quality use of PBS and decrease motivations for non-use of PBS. Intervention participants will receive personalized PBS Text Messages 3x per week (based on self-selections from the interactive online intervention) for 8 consecutive weeks timed to occur on a random weekday as well as Friday and Saturday.
Pediatric bronchial asthma is a common disease that severely threatens physical and mental health of children. It's urgent to explore effective ways to alleviate the pain caused by asthma.

In our research, 160 asthmatic children are randomly divided into a Chinese medication group (80 cases) and a Western medication control group(80 cases). Patients in the Chinese medication group are treated with a series of experienced chinese herbal formulas, whereas the western medication control group received a leukotriene receptor antagonist and a bronchial relaxant. The Chinese medicine syndromes and western medicine symptoms are scored. Pulmonary function and asthma control test score will be applied in this study. We evaluate the situation of asthma from different aspects, including index of pulmonary function and score of asthma control test. Real-time PCR was used to determine the mRNA expression levels of some inflammatory mediators in peripheral.
Mitochondria function and integrity may impact postmortem metabolism and meat quality development. Adaptations in heat tolerant Brahman may persist to limit cellular stress postmortem. Our objective was to evaluate glycolysis, pH decline, and mitochondria function in longissimus lumborum (LL) from Angus and Brahman steers (N = 28) early postmortem (1 to 6 h) and after rigor (24 h). We evaluated metabolites of anaerobic glycolysis, ATP, pH, and temperature, and determined mitochondria oxygen consumption rate (OCR) in permeabilized fibers. The main effects of breed (b) and time (t) and the interaction were tested. Brahman LL contained greater ATP during the first 6 h postmortem; Brahman also tended to exhibit a slower pH decline (b × t, P = 0.07) and more rapid temperature decline (b × t, P < 0.001), but metabolites of anaerobic glycolysis were not different. Mitochondria in Brahman and Angus LL were well-coupled and respired at 1 h postmortem. However, outer membrane integrity became increasingly compromised postmortem (t, P < 0.001). Brahman tended to exhibit greater electron transport system capacity (b, P < 0.1) and had greater capacity for oxidative phosphorylation (complex I and II substrates) at 6 h compared with Angus (P < 0.001). In totality, greater ATP, slower pH decline, and enhanced mitochondria capacity indicate that Brahman possess mitochondrial properties or cellular adaptations that help protect the cell during energy stress postmortem. Slower pH and more rapid temperature decline in LL from Brahman may also help preserve mitochondria function postmortem.
The participants were informed about the research and the mean score was calculated by applying the Vaginal Breech Delivery Management Knowledge Test to the participants before the vaginal delivery management training of the breech-presented fetus was given within the scope of the Risky Delivery and Postpartum Period Course. On the same date as the playgroup, but at a different time and in a class, the researcher gave a theoretical lesson through the presentation prepared in the powerpoint program about the birth management of a breech-presented fetus in the classroom as in the traditional education method. After the lesson, the Vaginal Breech Birth Management Post-Knowledge Test and the General Satisfaction Level Test were administered to the participants again. Test-retest reliability was calculated by applying the Vaginal Breech Delivery Management Knowledge Retention Test 14 days later.
Routine coagulation tests such as Prothrombin Time (PT) and Activated Partial Thromboplastin Time (aPTT) are relatively insensitive measures of the activity of ARIXTRA and international standards of heparin or LMWH are not calibrators to measure anti-Factor Xa activity of ARIXTRA. If unexpected changes in coagulation parameters or major bleeding occur during therapy with ARIXTRA, discontinue ARIXTRA. In postmarketing experience, isolated occurrences of aPTT elevations have been reported following administration of ARIXTRA [see Adverse Reactions (6.5)].

Periodic routine complete blood counts (including platelet count), serum creatinine level, and stool occult blood tests are recommended during the course of treatment with ARIXTRA.

The anti-Factor Xa activity of fondaparinux sodium can be measured by anti-Xa assay using the appropriate calibrator (fondaparinux). The activity of fondaparinux sodium is expressed in milligrams (mg) of the fondaparinux and cannot be compared with activities of heparin or low molecular weight heparins. [See Clinical Pharmacology (12.2, 12.3).]
In TENS group patients, 4 electrodes of the TENS device (2 on the front side: on the anterior right and left groin skin, 2 on the back side: on the right and left presacral skin) were placed 3-5 minutes before the biopsy procedure, and the application was started and TENS was applied throughout the procedure. continued. TENS was applied again for 30 minutes 2 hours after the procedure. Frequency of the TENS program applied in the conventional model: 100 Hz; pulse width: 150 μs; duration:30 minutes; The current intensity (amplitude: highest level 60 mA) is adjusted (according to individual tolerance by asking the patient) to create a tingling or pricking sensation that does not disturb the patient.Data were collected in three stages.
The subjects were screened and examined according to the protocol before enrollment。The dose of the enrolled subjects was increased according to the following 7 dose groups: 0.1mg/kg, 0.5mg/kg, 1.0mg/kg, 1.5mg/kg, 1.8mg/kg, 2.0mg/kg and 2.3 mg/kg. (according to the data of the previous study, when the dose climbs to 1.5 mg / kg, there is a serious decline of neutrophils, which shall be subject to the principle of 3 + 3. If the dose group reaches 6 patients and the DLT is less than or equal to 1 case, it continues to increase sequentially (1.8 mg/kg, 2.0 mg/kg, and 2.3 mg/kg). Whether to continue the dose increase or not shall be discussed and decided by the researcher and the sponsor). The incremental process is divided into groups according to the principle of 3 + 3 dose increment. The subjects randomly receive intravenous drip of TRS005 in chronological order. Each subject first carries out a single dose study, and then carries out multiple continuous doses. The first dose is given once in D1. After 21 days of observation, it is decided whether to continue multiple continuous doses according to the situation. They are given once in C2D1, C3D1, C4D1, C5D1 and C6D1 respectively, for a total of 6 cycles and 6 times.

Based on the data of pharmacokinetics, safety, tolerability and efficacy of the previous 4 dose groups, the dose group of 1.0 mg/kg, 1.5 mg/kg or 1.8 mg/kg (when the maximum dose exceeds 1.8 mg/kg) will enter the extended trial phase and continue to complete 6 cycles of treatment according to the original research principles. It is expected that the number of research cases in each group will accumulate to 10, a total of about 30 cases; If 2 cases of DLT occur in 6 cases in the 1.5 mg/kg dose group, the dose increase will not continue. At this point, an additional 1.3 mg/kg dose group is required to enter the study, while the extended dose group is expected to select 1.0 mg/kg 1.3 mg/kg, with a cumulative enrollment of 12 subjects, for a total of 24 cases.
Cervical radiculopathy is a disorder involving dysfunction of the cervical nerve roots commonly secondary to cervical spine degenerative changes such as disk herniation and/or foraminal stenosis compressing the nerve roots. Clinical manifestations are pain in neck and one or both of the upper extremities, as a result of compression or irritation of nerve roots in the cervical spine. It can be accompanied by motor, sensory, or reflex deficits. It is most common in persons 45-60 years of age, which result in terrible chronic pain. Eye hand coordination is the ability to do activities which require the simultaneous use of hands and eyes. It is a complex cognitive skill which unites visual and motor skills in the person and allowing the hands to guide by the visual stimulations. It lies at the core of our daily activities and interactions with objects and people around us as to be a defining characteristic of typical human life. Previous studies show that there was a marked alteration in the hand function in subjects with the cervical radiating pain. Since there was no study which investigated the relationship between cervical radiculopathy and eye hand coordination despite it is an important skill that adults use in countless activities of daily living and during working.
The arrangement (10) has programmable personal medical devices (20), where each device comprises a programmable data transmission interface for data transmission from and to the medical devices using one of data transmission protocols (15, 15', 15''). A control unit changes the protocols and accepts data transmission via the interface. An identification is made to identify the medical device. A management unit (25) transmits the protocols from a storage unit (50) on a basis of a designation query (100) to the control unit of the medical device to change the protocols. An independent claim is also included for a method for managing a data transmission layer of a programmable personal medical device such as implantable medical device e.g. cardiac pacemaker and defibrillator.