anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Locally advanced or recurrent prostate cancer which invades adjacent pelvic organs, bone or other soft tissue structures is a rare situation. This study aimed to report the outcomes of ten consecutive patients who underwent total pelvic exenteration for prostate cancer at a high-volume specialist centre. Two patients had locally advanced primary tumours, while eight had locally recurrent prostate cancer. Median operating time, blood loss, ICU stay, and hospital stay was 12.2 h (range 9.6-13.8), 2500 ml (500-3000), 4.5 days (2-7) and 36 days (21-78), respectively. There was no inpatient, 30-day, or 90-day mortality. Six patients developed a Clavien-Dindo III complication. R0 resection was achieved in eight patients. Median follow up was 16 months (range 2-77). At last follow up, five patients were alive without disease. These findings suggest that pelvic exenteration for locally advanced and recurrent prostate cancer is safe and represents a potentially curative treatment option for highly selected patients.
MicroRNA-like RNAs (milRNAs) play a significant role in the infection process by plant-pathogenic fungi. However, the specific functions and regulatory mechanisms of fungal milRNAs remain insufficiently elucidated. This study investigated the function of Foc-milR138, an infection-induced milRNA secreted by Fusarium oxysporum f. sp. cubense (Foc), which is the causal agent of Fusarium wilt of banana. Initially, through precursor gene knockout and phenotypic assessments, we confirmed that Foc-milR138 acts as a virulent milRNA prominently upregulated during the early stages of Foc infection. Subsequent bioinformatic analyses and transient expression assays in Nicotiana benthamiana leaves identified a host receptor-like kinase gene, MaLYK3, as the direct target of Foc-milR138. Functional investigations of MaLYK3 revealed its pivotal role in triggering immune responses of N. benthamiana by upregulating a suite of resistance genes, bolstering reactive oxygen species (ROS) accumulation and callose deposition, thereby fortifying disease resistance. This response was markedly subdued upon co-expression with Foc-milR138. Expression pattern analysis further verified the specific suppression of MaLYK3 by Foc-milR138 during the early root infection by Foc. In conclusion, Foc secretes a virulent milRNA (Foc-milR138) to enter the host banana cells and inhibit the expression of the plant surface receptor-like kinase MaLYK3, subverting the disease resistance activated by MaLYK3, and ultimately facilitating pathogen invasion. These findings shed light on the roles of fungal milRNAs and their targets in resistance and pathogenicity, offering promising avenues for the development of disease-resistant banana cultivars.
PURPOSE:To provide the subject treating agent containing 1alpha, 25 dihydroxyvitamin D3-26,23-lactone as an active component and effective for promoting the differentiation of cartilage cell and promoting the collagen synthesis and proteoglycan synthesis in cartilage cell. CONSTITUTION:The treating agent for cartilage dysbolism contains 1alpha, 25- dihydroxyvitamin D3-26,23-lactone of formula (one of metabolic products of 1alpha, 25-dihydroxyvitamin D3) as an active component. Especially preferable compounds of formula are 23(S)25(R)-1alpha, 25-dihydroxyvitamin D3-26,23-lactone and 23(R)25(S)-1alpha, 25-dihydroxyvitamin D3-26,23-lactone. The agent is effective for the treatment of cartilage dysbolism, especially caused by the depression of the collagen and/or proteoglycan synthesis capability in cartilage matrix, particularly arthrosis deformans and rheumatoid arthritis. It is administered preferably in the form of an oral drug or injection. The agent is preferably further incorporated with TGF-beta1 and/or IGF-I.
FIELD: medicine. ^ SUBSTANCE: invention relates to compositions for delivery of substances for oral cavity care to mouth surfaces, such as teeth. Compositions according to invention include: (a) silicone pressure sensitive adhesive, selected from blocked copolymers silicone/resin, which are from nearly 25% to totally blocked and are obtained by polycondensation of polydialkylsiloxan with blocked silanol groups and silicon-containing resin with blocked hydroxyl groups and following carrying out of product polycondensation reaction with trialkysilyl blocking agent; (b) plastifying material, able to soften silicone pressure- sensitive adhesive and containing liquid diorganopolysiloxane polymer; (c) water soluble bioadhesive polymer; (d) hydrophilic surface-active substance, and (e) at least one substance for oral cavity care, for example, one active substance for whitening. Also describes are methods of controlled and delayed release of active substances for oral cavity care and delivery of substance for oral cavity care to at least one surface of oral cavity with application of these compositions. ^ EFFECT: application of said blocked copolymers silicone/resin in combination with water soluble bioadhesive polymer and hydrophilic surface-active substance provides matrix for controlled and delayed release of active substances for oral cavity care. ^ 19 cl, 4 tbl, 4 ex
Lipocalin-2, a neutrophil gelatinase-associated lipocalin, is a 25-kDa secreted protein implicated in a broad range of inflammatory diseases affecting the brain and periphery. It is a pleotropic protein expressed by various immune and nonimmune cells throughout the body. Importantly, the surge in lipocalin-2 levels in disease states has been associated with a myriad of undesirable effects, further exacerbating the ongoing pathological processes. In the brain, glial cells are the principal source of lipocalin-2, which plays a definitive role in determining their functional phenotypes. In different central nervous system pathologies, an increased expression of glial lipocalin-2 has been linked to neurotoxicity. Lipocalin-2 mediates a crosstalk between central and peripheral immune cells under neuroinflammatory conditions. One intriguing aspect is that elevated lipocalin-2 levels in peripheral disorders, such as cancer, metabolic conditions, and liver diseases, potentially incite an inflammatory activation of glial cells while disrupting neuronal functions. This review comprehensively summarizes the influence of lipocalin-2 on the exacerbation of neuroinflammation by regulating various cellular processes. Additionally, this review explores lipocalin-2 as a mediator of neuroimmune crosstalk in various central nervous system pathologies and highlights the role of lipocalin-2 in carrying inflammatory signals along the neuroimmune axis.
Purpose: Our single-centre retrospective study aimed to investigate the relationship between preoperative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) findings and apparent diffusion coefficient (ADC) values and lymphovascular invasion (LVI) status of the lesions in patients with clinically-radiologically lymph node-negative invasive breast cancer. Methods: A total of 250 breast lesions diagnosed in preoperative magnetic resonance imaging were identified. All patients were divided into 2 subgroups: LVI-negative and LVI-positive according to the pathological findings of surgical specimens. The 2 groups' DCE-MRI findings, ADC values, and histopathological results of lesions were compared. Results: LVI was detected in 100 of 250 lesions. Younger age than 45 years and larger lesion size than 20 mm were found to be associated with the presence of LVI (P < .001). High histological and nuclear grade (P = .001), HER2-enriched molecular subtype (P = .001), and Ki-67 positivity (P = .016) were significantly associated with LVI. The LVI positivity rate was significantly higher in the lesions with medium-rapid initial phase kinetic curve and washout delayed phase kinetic curve (P = .001). The presence of LVI was significantly associated with the presence of peritumoural edema, sentinel lymph node metastasis, adjacent vessel sign, and increased whole breast vascularity (P < .001). When diffusion-weighted imaging findings were evaluated, it was determined that tumoural ADC values lower than 1068 × 10-6 mm2/second (P = .002) and peritumoural-tumoural ADC ratios higher than 1.5 (P = .001) statistically increased the probability of LVI. Conclusion: The patient's age, various histopathological and DCE-MRI findings, tumoural ADC value, and peritumoural-tumoural ADC ratio may be useful in the preoperative prediction of LVI status in breast cancer lesions.
The study design will be a randomized controlled trial regarding a physical activity intervention. A 1:1 randomization will be applied with intervention schools and matched control schools. The intervention school will recieve the BOOSTH intervention. The intervention duration is 6 months. Measurements will be performed at baseline and 3, 6 and 12 months after the start.

The investigational treatment is the BOOSTH physical activity intervention. Children in the intervention school will start with the BOOSTH intervention on top of the regular PE lessons. The child will receive the BOOSTH activity tracker. The child (under supervision of the teacher) needs to download the BOOSTH sync app and the BOOSTH game app. Therefore it is important that the school works with a device with Bluetooth. We will create a login account for each child. After installing the apps, the activity tracker measures step counts, which are translated into activity points. These activity points will be used to unlock levels in the BOOSTH game app. The child synchronizes their activity points, with Bluetooth connection, in the BOOSTH sync app and immediately the child can open the BOOSTH game app to play a level in the game. The child needs seven green lights (corresponding to 30 minutes of performed physical activity) to unlock a level in the game. The first four levels are for free, to gain the interests of the child, but thereafter the child needs to be physically active to unlock the rest of the levels in the game.
Hypertension (HTN) is a prevalent risk factor for cardiovascular, cerebrovascular, and renal disease, and disproportionately affects African Americans (AA). Although HTN awareness and treatment rates among AA are similar to, or exceed non-Hispanic whites, control of HTN among AAs remains inadequate. Randomized clinical trials have demonstrated the effectiveness of lifestyle measures in lowering BP, including the Dietary Approaches to Stop Hypertension (DASH) diet, which lowers systolic BP 6-14 mmHg. DASH calls for increased consumption of fruits, vegetables, and low fat dairy, and decreased saturated fat and sodium intake. There is limited evidence that DASH has been widely adopted by the public and AA from lower income communities may be less able to adopt DASH as currently disseminated due to barriers related to income, education, attitudes about foods, health beliefs, and neighborhood availability of healthier foods. We propose to utilize quantitative and qualitative research techniques (including focus groups and surveys) to assess environmental, intra-personal, interpersonal and cultural factors that could affect the translation of the DASH diet in a low-income AA community, then utilize the knowledge gathered to adapt existing intervention strategies and tools. These will provide the materials for a randomized three month pilot lifestyle intervention implementing the DASH diet. The 40 participants will be aged 21+ and have pre-HTN or HTN with blood pressure between 120-150/80-95 mmHg on 0,1 or 2 antihypertensive agents, and will be AA residents of two zip codes in Winston-Salem (a lower-income area whose population is significantly minority).
The aim of this study is to investigate the effectiveness of the 'SmartLife' intervention with tailored feedback on sedentary behavior and physical activity among adolescents and to investigate the engagement in the exergame. One intervention group will receive a version of the exergame that tailors feedback. This means tailored feedback will be based on data from a sensor which is integrated in a T-shirt and paired to the game. The active control group will receive a different version of the game, that does not provide tailored feedback.

Both groups will be compared to investigate their level of engagement in the game. A passive control group will be included that will be asked to continue their daily routines as usual. All three groups will be compared to determine the effectiveness of the 'SmartLife' intervention on physical activity and sedentary behavior.
Participants will be instructed to take home the stimulation equipment. Participants and their study partners (if applicable) will be trained on how to use the device before leaving the facility. Each device case also includes an instruction document. Participants and/or study partners (if applicable) will keep a manual log of daily operation, including the time of day used, whether the participant felt drowsy or, was able to complete the entire session, or if the participant was unable to complete the therapy that day. Finally, study staff will contact participants monthly every 2 weeks to ensure compliance, assess adverse events, and log concomitant medications.
Lead acetate (PbAc) is a compound that produces toxicity in many tissues after exposure. Sinapic acid (SNP) possesses many biological and pharmacological properties. This study aimed to investigate the efficacy of SNP on the toxicity of PbAc in lung tissue. PbAc was administered orally at 30 mg/kg and SNP at 5 or 10 mg/kg for 7 days. Biochemical, genetic, and histological methods were used to investigate inflammatory, apoptotic, endoplasmic reticulum stress, and oxidative stress damage levels in lung tissue. SNP administration induced PbAc-reduced antioxidant (GSH, SOD, CAT, and GPx) and expression of HO-1 in lung tissue. It also reduced MDA, induced by PbAc, and thus alleviated oxidative stress. SNP decreased the inflammatory markers NF-κB, TNF-α and IL-1β levels induced by PbAc in lung tissue and exhibited anti-inflammatory effect. PbAc increased apoptotic Bax, Apaf-1, and Caspase-3 mRNA transcription levels and decreased anti-apoptotic Bcl-2 in lung tissues. SNP decreased apoptotic damage by reversing this situation. On the other hand, SNP regulated these markers and brought them closer to the levels of the control group. PbAc caused prolonged ER stress by increasing the levels of ATF6, PERK, IRE1α, GRP78 and this activity was stopped and tended to retreat with SNP. After evaluating all the data, While PbAc caused toxic damage in lung tissue, SNP showed a protective effect by reducing this damage.
It has been presumed that rheumatoid arthritis (RA) joint pain is related to inflammation in the synovium; however, recent studies reveal that pain scores in patients do not correlate with synovial inflammation. We developed a machine-learning approach (graph-based gene expression module identification or GbGMI) to identify an 815-gene expression module associated with pain in synovial biopsy samples from patients with established RA who had limited synovial inflammation at arthroplasty. We then validated this finding in an independent cohort of synovial biopsy samples from patients who had early untreated RA with little inflammation. Single-cell RNA sequencing analyses indicated that most of these 815 genes were most robustly expressed by lining layer synovial fibroblasts. Receptor-ligand interaction analysis predicted cross-talk between human lining layer fibroblasts and human dorsal root ganglion neurons expressing calcitonin gene-related peptide (CGRP+). Both RA synovial fibroblast culture supernatant and netrin-4, which is abundantly expressed by lining fibroblasts and was within the GbGMI-identified pain-associated gene module, increased the branching of pain-sensitive murine CGRP+ dorsal root ganglion neurons in vitro. Imaging of solvent-cleared synovial tissue with little inflammation from humans with RA revealed CGRP+ pain-sensing neurons encasing blood vessels growing into synovial hypertrophic papilla. Together, these findings support a model whereby synovial lining fibroblasts express genes associated with pain that enhance the growth of pain-sensing neurons into regions of synovial hypertrophy in RA.
The invention relates to cosmetic compositions which are intended to improve the firmness of the skin by increasing adhesion of cutaneous cells in relation to one another and the basal lamina. The aforementioned compositions comprise a cosmetically-effective quantity of peptides having general formula X-isoleucyl-lysyl-valyl-alanyl-valine-Y, known as X-SEQ ID No. 1-Y (FIG.  1 ). The invention also relates to the use of X-SEQ ID No. 1-Y peptides in the preparation of cosmetic compositions which are intended to improve the firmness of the skin.
The invention relates to the technical field of medicines, discloses a preparation method of a phenylpropanoid compound, and particularly relates to a phenylpropanoid compound which is obtained by being separated from dried roots of moghania macrophylla (Willd.) O Ktze.. The phenylpropanoid compound is prepared through the steps of solvent extraction, column chromatographic separation and liquid phase preparation, separation and purification. The phenylpropanoid compound obtained through the method is reported for the first time and is high in purity. It is proved through experiments that the obtained novel phenylpropanoid compound can inhibit expression effects of cell inflammatory factors of TNF-alpha, IL-1 beta and IL-6, has an inhibiting effect on hydroxyl free radicals (-OH), has anti-inflammatory and antioxidant activities, is beneficial for treatment of various inflammatory diseases such as cervicitis, endometritis, pelvic inflammation, mastitis, faucitis and/or arthritis and can be developed into a novel drug. The compound is the phenylpropanoid compound with the structural formula as shown in a formula (I) and pharmaceutically acceptable salts thereof. Please see the formula (I) in the description.
Human papillomavirus (HPV) infection is a causative factor in the occurrence and progression of oropharyngeal squamous cell carcinoma (OPSCC). In recent years, clinical studies have found that HPV-positive OPSCC patients may present a better prognosis than HPV-negative patients, yet the underlying causes are unclear. This study aimed to investigate the relevance of HPV infection and the prognosis of OPSCC. On this basis, we aimed to establish a prediction model to accurately predict the prognosis and guide clinical practice. We analysed the records of 233 patients with OPSCC. Cox regression was applied to identify factors associated with survival. Moreover, variables with significant discrepancies were integrated into a nomogram model to predict prognosis. The results showed that HPV was an independent prognostic factor for OS and PFS. Immunoglobulin Heavy Constant Mu (IGHM) mRNA was significantly upregulated in patients with HPV-positive OPSCC. Crucially, IGHM expression was associated with better prognosis. The receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis both confirmed that the prognostic model exhibits good performance. In summary, HPV infection were independent prognostic factors for OPSCC. IGHM may be the key contributors to the prognostic differences in HPV-associated OPSCC. This nomogram model was able to accurately predict the prognosis of patients.
OBJECTIVES: Parental interpartner conflict is a highly prevalent form of family risk that is stressful for adolescents with ramifications for their sleep. Multiple studies have demonstrated that adolescents from high-conflict homes are at risk for sleep problems. Building on this literature, we conducted novel analyses and investigated whether exposure to interpartner conflict in adolescence predicts sleep problems in the subsequent developmental period of emerging adulthood.
METHODS: We used a rigorous four-wave design spanning 8years (collected between 2012-2020). At wave 1, participants were 245 adolescents from diverse backgrounds (M age=15.74years; 67% White/European American, 33% Black/African American; 52% girls). Individuals participated again in their adolescence at wave 2 (M age=16.77) and wave 3 (M age=17.69). Participants returned for wave 4 in emerging adulthood (M age=22.97). Adolescents reported on their parents' interpartner conflict (intense and frequent conflict). Sleep duration (minutes) and quality (efficiency, long wake episodes) were measured using actigraphy.
RESULTS: After controlling for autoregressive effects and several covariates, findings from a structural equation model revealed that greater exposure to parental interpartner conflict in adolescence predicted reduced sleep efficiency and more long wake episodes in emerging adulthood.
CONCLUSIONS: Results build on the literature to consider sleep in the family context and are among the first to illustrate that exposure to parental interpartner conflict in adolescence predicts sleep problems in emerging adulthood. Continued investigations into the antecedents of sleep problems in emerging adulthood may benefit from considering past exposure to family risk.
A method and implants provide for relieving pressure form a region of the brainstem within the cranium of a subject with a neuroendocrine servomeehanism. The pressure results from the compression of the region by a blood vessel. The method includes gaining access to the region using a first surgical technique; exposing the region according to a second surgical technique; lifting the blood vessel from the region according to a third surgical technique, thereby providing the pressure relief; and inserting a neurovascular bridge implant between the blood vessel and the region to maintain the pressure relief. The neuroendocrine servomeehanism is responsive to the pressure relief on the region, causing amelioration of a disease. One neuroendocrine servomechanism can include the panereas of the subject, and the pressure relief ameliorates non-insulin-dependent diabetes mellitus. The neurovascular bridge implant can be a preconfigured shredded plastic implant, made of polytetrafluorocthylene, or a preconfigured thermoplastic implant, made of a polyurethane-based material having a glass-transition temperature of between 20 DEG C to 60 DEG C and a transition band of about 8 DEG C.
Compsn. contains active constituent isobutyric acid 3-trifluoromethyl-4-nitroanilide. Used for topical treatment by virtue of the antiandrogenic activity. Composn. is well tolerated by local application. A typical lotion for application 2 or 3 times daily contained the anilide (2.5g) and essence of lemon and bergamot (0.1kg) in propylene glycol to a total of 100g.
PURPOSE:To obtain a novel synthetic chondroitin polysulfate by treating a salt of chondroitin-4-sulfate or dermatan sulfate with a sulfating agent in a polar organic solvent, thereby highly sulfating the 6-OH of the N-acetylgalactosamine residue. CONSTITUTION:The objective compound having S-content of 7.3-12.5% and a molecular weight of 5,000-100,000, and composed of the recurring unit of formula (R1O, R2O, R3O and R4O are sulfate or hydroxide group, provided that the sulfation degree of R1O and R2O is 20-100% and that of R3 and R4 is <=25%, X is COOH or H; when X is COOH, Y is H and when X is H, Y is COOH) can be prepared by treating a salt of chondroitin-4-sulfate or dermatan sulfate with a sulfating agent (e.g. chlorosulfonic acid, sulfamic acid, etc.) in an organic solvent such as pyridine, THF, etc., in the state of homogeneous solution, preferably at 0-20 deg.C for 3-8hr. USE:Effective to nephritis. It has higher activity than chondroitin-4-sulfate with comparable side effect.
Parturients who received IV thiopental 2 mg kg-1 and if necessary additional 50 mg immediately after spinal anesthesia until reaching at least Ramsay sedation score of 3 (1: patient anxious, agitated or restless, 6: patient with no response to light glabella tap or loud auditory stimulus.).