anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The present invention relates to thyroid cream for external application. The thyroid cream contains an antithyroid drug, glucocorticoid and a drug penetration promoting agent and is directly and externally applied on skins at an anterior thyroid part. The thyroid cream directly penetrates skins and enters thyroid to treat hyperthyroidism disease symptom through the drug. The dosage of the used drug is small to quickly control the premonition of hyperthyroidism crisis and quickly correct hyperthyroidism complication. The thyroid cream has the advantages of no hormone side effect and safe use. A patient suffering from hyperthyroidism is treated through the drug of the present invention, relapse rate is very low, and therapeutic effect is good. The drug has the advantages of simple production technique and sufficient raw material and has obvious social benefit and economic benefit.
Supplementation with inorganic nitrate, which is most commonly administered in the form of concentrated nitrate-rich beetroot juice shots, has emerged as an ergogenic nutritional strategy. Beetroot juice ingestion has been reported to enhance endurance and high-intensity intermittent exercise performance in running and cycling. These improvements are attributed to augmented muscle contractility, force production and blood flow distribution, specifically in muscle groups comprised predominantly of type II muscle fibers. Together, such changes provide a strong physiological rationale supporting the potential for dietary nitrate to enhance high-power and high-velocity muscle contractions since type II muscle fibers are heavily activated during these tasks. However, the influence of dietary nitrate on resistance exercise performance is substantially underdeveloped with most previous studies having assessed the effect of nitrate supplementation on running and cycling endurance and high-intensity intermittent exercise. Moreover, there is no information on the dose of nitrate required to evoke ergogenic effects during resistance exercise, which greatly hinders the potential implementation of beetroot juice as a research-informed performance enhancing supplement for resistance exercise. Thus, the proposed project will investigate if acute dietary nitrate ingestion, provided as nitrate-rich beetroot juice, elicits improvements in various neuromuscular performance parameters (e.g., power, velocity) during resistance exercise performance when compared to supplementing the diet with a nitrate-depleted beetroot juice placebo. The investigators will also investigate the dose-response effect of beetroot juice on resistance exercise performance by providing low (70 ml i.e., \~6.5 mmol or \~400 mg of nitrate), moderate (140 ml i.e., \~13 mmol or \~800 mg of nitrate) and a high nitrate dose (280 ml i.e., \~26 mmol or \~1600 mg of nitrate) of concentrated beetroot juice. This project will provide insight to practitioners (coaches/athletes) aiming to enhance performance in settings where muscular power and speed are key determinants for success, as well as to scientists exploring the efficacy of beetroot juice as a form of dietary nitrate supplementation to improve muscle contractile function.
Participants will take nirogacestat by mouth every day of each 28-day study cycle. Based on when you enroll in this study, you will take nirogacestat either 1 time a day at about the same time each day OR 2 times a day, about 12 hours apart.
Asthma with eosinophilic inflammation in the airways and/or blood eosinophilia is associated with clinical severity including the risk of exacerbations and relevant comorbidities (e.g. nasal polyposis). Interleukin-5 (IL-5) is a cytokine essential for eosinophil trafficking and survival. Clinical trials of blocking IL-5 with anti-IL-5 antibodies (mepolizumab and reslizumab) in patients with uncontrolled eosinophilic asthma resulted in an improvement in exacerbation rate and oral corticosteroid use. In some studies with mepolizumab and reslizumab there was a beneficial effect on lung function (FEV1). In addition, many patients described a profound impact on asthma symptoms and quality of life in personal reports which is not uniformly reflected in clinical trials.

The MEMORY trial is the first to primarily evaluate the effect of mepolizumab treatment on pulmonary function in patients with severe eosinophilic asthma. Importantly, using spirometry and bodyplethysmography will allow to evaluate additional parameters beyond FEV1 that more closely mirror the pathophysiological changes and functional aspects of airflow limitation in asthma in real life, e.g. airway resistance, hyperinflation and diffusion capacity. The proposed trial will answer the important questions: if, and if so, which parameters of airway (patho-) physiology as assessed by bodyplethysmography best reflect clinical response to mepolizumab therapy in patients with severe eosinophilic asthma. In addition, the time course to clinical response will be assessed. Equally important, there is only a loose correlation between FEV1 and parameters of asthma control and asthma-related quality of life. This is why another new and important aspect of this trial is to carefully monitor asthma control and asthma quality in life in correlation with lung function changes beyond FEV1. Finally, it is tempting to speculate that the proposed trial will contribute to the question how to best define clinical response to mepolizumab.
OBJECTIVE: This cohort study was to assess the association between serum calcium levels and the risk of acute kidney injury (AKI) in acute myocardial infarction (AMI) patients.
METHODS: This study was analyzed using data of 1286 AMI patients aged ≥18 years who stayed in ICU more than 24 h in Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Univariable logistic regression model was established to identify potential covariates. Univariate and multivariable logistic regression models were used to analyze the association between serum calcium and the risk of AKI in patients with AMI. The association between serum calcium and the risk of AKI in patients with AMI was also shown by restricted cubic spline (RCS) plot. Odds ratio (OR) and 95% confidence interval (CI) were calculated.
RESULTS: The median follow-up time was 1.61 (1.23, 2.30) days, and 436 (33.90%) participants had AKI at the end of follow-up. After adjusting for covariates, elevated level of serum calcium level was related to reduced risk of AKI in AMI patients (OR = 0.88, 95%CI: 0.80-0.98). Decreased risk of AKI was found in AMI patients with serum calcium level of 8.40-8.90 mg/dL (OR = 0.54, 95%CI: 0.34-0.86) or ≥8.90 mg/dL (OR = 0.60, 95%CI: 0.37-0.99). The RCS plot depicted that serum calcium level was negatively correlated with the risk of AKI in patients with AMI.
CONCLUSIONS: AMI patients with AKI had lower serum calcium levels compared with those without AKI. Increased serum calcium level was associated with decreased risk of AKI in patients with AMI.
Pyrrolo[2,1-b]-3-benzazepines of the formula <IMAGE> and their salts, e.g. cis/trans geometrical isomers, are prepared in pure form or as mixture. The substituents are defined in Claim 1. These compounds are obtained by reacting an appropriate aminopropylidene-trisubstituted phosphorane with the appropriate ketone of the formula II. The isomers, preferably the E isomer, can be obtained from the mixture of isomers by chromatographic separation. The resulting compounds can be used as skeletal muscle relaxants or sedatives. <IMAGE>
In accordance with the present invention, a family of membrane fusion proteins and polynucleotides encoding the proteins have been identified. The proteins and polynucleotides are derived from the family Reoviridae. Two membrane fusion proteins have been isolated from reoviruses isolated from poikilothermic hosts: the p14 protein from reptilian reovirus (RRV) isolated from python, and the p16 protein from aquareovirus (AQV) isolated from salmon. The genes encoding these proteins have been cloned and sequenced. Analysis of the amino acid sequences of these proteins show that both lack the typical fusion peptide motif found in other membrane fusion proteins. Expression of these proteins in cells results in cell-cell fusion.
The endovascular procedure will be performed until 72 hours after surgical evacuation of chronic subdural hematoma. Embolization will be performed with non-adhesive embolizing fluids such as Onix®, Phil®, Squid® or Libro®.
PROBLEM TO BE SOLVED: To obtain an improving agent for hyper-remnant blood disease capable of remarkably inhibiting sthenia of the hyper-remnant blood disease but having improving activity and useful for preventing and curing arterial sclerosis by the participation of remnant-lipoprotein by bringing a specific highly unsaturated fatty acid as an effective ingredient. SOLUTION: This improving agent against hyper-remnant blood disease contains a highly unsaturated fatty acid of n-3 series, preferably eicosapentaenoic acid(EPA) and/or docosahexaenoic(DHA) acid as effective ingredients'. E.g. as an oil-containing fatty acid, an oil containing >=20% fatty acid based on the total fatty acid is preferable. Thus, it is preferable to use fish oil, etc., extracted from blueback fishes such as sardines, etc. It is preferable to administer about 100-5,000mg EPA or DHA per day.
A system for detecting cancerous status of a lymph node (LN). The system includes a lipid detection probe (LDP), an electrochemical stimulator-analyzer connected to the LDP, and a processing unit connected to the electrochemical stimulator-analyzer. The LDP includes three platinum hollow needle electrodes with three respective lipid sensitive parts coated with a layer of laser-assisted welded carbon nanotubes (CNTs). The three lipid sensitive parts are configured to be inserted into the LN. The processing unit includes a memory having processor-readable instructions and a processor. The processor is configured to access the memory and execute the processor-readable instructions to perform a method. The method includes measuring a RCT of the LN utilizing the electrochemical stimulator-analyzer and detecting a cancerous status of the LN by detecting the LN is cancer involved if the measured RCT is less than a reference RCT.
The system has a database including text and/or image information e.g. medicament information, associated to search words e.g. pharmaceutical central numbers, which are inputted via interfaces (5, 6). A flat monitor (2) reproduces the information. A processor executes a database request process as reaction of inputting the search words and represents the information on the monitor as reaction of the database request process. An electronic storage unit e.g. Universal serial bus (USB)stick, is accessed by one of the interfaces. An independent claim is also included for a method for representing customer specific advertisement in a shop.
According to the invention, essential oil of alpinia oxyphylla miq. is taken as a major research object, and the effect of the essential oil on promoting drug transdermal permeation is investigated. On the basis of systematic investigation, both fruit essential oil and leaf essential oil of the alpinia oxyphylla miq. are relatively strong in penetration enhancing effect; and when the concentration of the essential oil is 3%, the penetration enhancing effect of the fruit essential oil and the leaf essential oil on drugs is obviously better than that of a common skin penetration enhancer, namely azone. Based upon GC-MS analysis, as for major ingredients, the fruit essential oil and the leaf essential oil are different in contents of alkane terpene and oxy-terpene ingredients; therefore, the fruit essential oil and the leaf essential oil keep a certain difference in drug penetration enhancing effect. In addition, the result of a skin irritation test proves that the fruit essential oil and the leaf essential oil, at an appropriate concentration, can avoid any erythema or edema in animal skin. Therefore, the essential oil of the alpinia oxyphylla miq., with the significant penetration enhancing effect and safety to the skin, has a broad development and application prospect in the fields of drug delivery and cosmetics.
Participants will rest on day 1. Participants will return the following day where they will consume a high fat breakfast and lunch.
Human papillomavirus (HPV) infections are the primary drivers of cervical cancers, and often HPV DNA gets integrated into the host genome. Although the oncogenic impact of HPV encoded genes is relatively well known, the cis-regulatory effect of integrated HPV DNA on host chromatin structure and gene regulation remains less understood. We investigated genome-wide patterns of HPV integrations and associated host gene expression changes in the context of host chromatin states and topologically associating domains (TADs). HPV integrations were significantly enriched in active chromatin regions and depleted in inactive ones. Interestingly, regardless of chromatin state, genomic regions flanking HPV integrations showed transcriptional upregulation. Nevertheless, upregulation (both local and long-range) was mostly confined to TADs with integration, but not affecting adjacent TADs. Few TADs showed recurrent integrations associated with overexpression of oncogenes within them (e.g. MYC, PVT1, TP63 and ERBB2) regardless of proximity. Hi-C and 4C-seq analyses in cervical cancer cell line (HeLa) demonstrated chromatin looping interactions between integrated HPV and MYC/PVT1 regions (~ 500 kb apart), leading to allele-specific overexpression. Based on these, we propose HPV integrations can trigger multimodal oncogenic activation to promote cancer progression.
BACKGROUND: Household air pollution is associated with stunted growth in infants. Whether the replacement of biomass fuel (e.g., wood, dung, or agricultural crop waste) with liquefied petroleum gas (LPG) for cooking can reduce the risk of stunting is unknown.
METHODS: We conducted a randomized trial involving 3200 pregnant women 18 to 34 years of age in four low- and middle-income countries. Women at 9 to less than 20 weeks' gestation were randomly assigned to use a free LPG cookstove with continuous free fuel delivery for 18 months (intervention group) or to continue using a biomass cookstove (control group). The length of each infant was measured at 12 months of age, and personal exposures to fine particulate matter (particles with an aerodynamic diameter of ≤2.5 μm) were monitored starting at pregnancy and continuing until the infants were 1 year of age. The primary outcome for which data are presented in the current report - stunting (defined as a length-for-age z score that was more than two standard deviations below the median of a growth standard) at 12 months of age - was one of four primary outcomes of the trial. Intention-to-treat analyses were performed to estimate the relative risk of stunting.
RESULTS: Adherence to the intervention was high, and the intervention resulted in lower prenatal and postnatal 24-hour personal exposures to fine particulate matter than the control (mean prenatal exposure, 35.0 μg per cubic meter vs. 103.3 μg per cubic meter; mean postnatal exposure, 37.9 μg per cubic meter vs. 109.2 μg per cubic meter). Among 3061 live births, 1171 (76.2%) of the 1536 infants born to women in the intervention group and 1186 (77.8%) of the 1525 infants born to women in the control group had a valid length measurement at 12 months of age. Stunting occurred in 321 of the 1171 infants included in the analysis (27.4%) of the infants born to women in the intervention group and in 299 of the 1186 infants included in the analysis (25.2%) of those born to women in the control group (relative risk, 1.10; 98.75% confidence interval, 0.94 to 1.29; P = 0.12).
CONCLUSIONS: An intervention strategy starting in pregnancy and aimed at mitigating household air pollution by replacing biomass fuel with LPG for cooking did not reduce the risk of stunting in infants. (Funded by the National Institutes of Health and the Bill and Melinda Gates Foundation; HAPIN ClinicalTrials.gov number, NCT02944682.).
<P>PROBLEM TO BE SOLVED: To provide a method for delivering nucleic acid into cells, and a vector effective for delivering a polynucleotide, i.e. nucleic acid-containing microparticles having a size suitable for phagocytosis, into phagocytes without spoiling nucleic acid integrity.  <P>SOLUTION: A microparticle preparation comprising a polymer substrate and a nucleic acid expression vector is provided. The polymer substrate includes one or more synthetic polymers having solubility in water of less than about 1 mg/L. At least about 90% of the microparticles have a diameter less than about 100 micrometers. The nucleic acid is either RNA at least 50% of which is in the form of closed circles, or circular DNA plasmid molecules at least 50% of which are supercoiled.  <P>COPYRIGHT: (C)2010,JPO&INPIT
During the 12 week control period, subjects are to maintain their normal, daily-living activities. Control group participants will be given the option to enroll in the AE training group after completion of the original Control group trial period.
BACKGROUND: Homozygous mutations in the APOA5 gene constitute a rare cause of monogenic hypertriglyceridemia, or familial chylomicronemia syndrome (FCS). We searched PubMed and identified 16 cases of homozygous mutations in the APOA5 gene. Severe hypertriglyceridemia related to monogenic mutations in triglyceride-regulating genes can cause recurrent acute pancreatitis. Standard therapeutic approaches for managing this condition typically include dietary interventions, fibrates, and omega-3-fatty acids. A novel therapeutic approach, antisense oligonucleotide volanesorsen is approved for use in patients with FCS.
CASE PRESENTATION: We report a case of a 25-years old Afghani male presenting with acute pancreatitis due to severe hypertriglyceridemia up to 29.8 mmol/L caused by homozygosity in APOA5 (c.427delC, p.Arg143Alafs*57). A low-fat diet enriched with medium-chain TG (MCT) oil and fibrate therapy did not prevent recurrent relapses, and volanesorsen was initiated. Volanesorsen resulted in almost normalized triglyceride levels. No further relapses of acute pancreatitis occurred. Patient reported an improve life quality due to alleviated chronic abdominal pain and headaches.
CONCLUSIONS: Our case reports a rare yet potentially life-threatening condition-monogenic hypertriglyceridemia-induced acute pancreatitis. The implementation of the antisense drug volanesorsen resulted in improved triglyceride levels, alleviated symptoms, and enhanced the quality of life.
Lidocaine hydrochloride exerts an antiarrhythmic effect by increasing the electric stimulation threshold of the ventricle during diastole. In usual therapeutic doses, lidocaine hydrochloride produces no change in myocardial contractility, in systemic arterial pressure, or in absolute refractory period.

About 90% of an administered dose of the drug is metabolized in the liver. The remaining 10% is excreted unchanged via the kidneys.

Lidocaine toxicity is related to systemic blood levels. The decreased clearance and longer half-life of lidocaine should be taken into consideration with prolonged (24 hour) infusions. Constant rate of infusion may result in toxic accumulation of lidocaine. Infusion should be reduced to approximately one-half to compensate for decreased rate of clearance and concomitant or prior administration of propranolol may further increase blood concentrations by as much as 30% in patients without cardiac or hepatic failure. In clinical studies, patients over 65 years showed decreased lidocaine clearance. This was partly due to the tendency of elderly patients to have lower body weight and the increased risk of cardiac failure in these patients.

This solution provides approximately 170 calories per liter.
The pericapsular nerve group (PENG) block is an ultrasound-guided approach, first described by Giron-Arango et al. for the blockade of the articular branches of the femoral, obturator and accessory obturator nerves that provide sensory innervation to the anterior hip capsule \[5,6\]. In the PENG block, a low-frequency, curvilinear probe is used to visualize the anterior inferior iliac spine, iliopsoas tendon, and iliopubic eminence. After placing a subcutaneous skin wheel with lidocaine, a blunt regional anesthesia needle is inserted using in-plane ultrasound guidance. The needle is advanced until the tip lies on the lateral and inferior margin of the iliopsoas tendon between the anterior inferior iliac spine (lateral) and iliopubic eminence (deep).
Cases of methemoglobinemia, with resultant hospitalization, have been reported postmarketing in association with dapsone gel, 5% treatment. Patients with glucose‐6‐phosphate dehydrogenase deficiency or congenital or idiopathic methemoglobinemia are more susceptible to drug‐induced methemoglobinemia. Avoid use of dapsone gel, 5% in those patients with congenital or idiopathic methemoglobinemia. 

Signs and symptoms of methemoglobinemia may be delayed some hours after exposure. Initial signs and symptoms of methemoglobinemia are characterized by a slate grey cyanosis seen in, e.g., buccal mucous membranes, lips and nail beds. Advise patients to discontinue dapsone gel, 5% and seek immediate medical attention in the event of cyanosis. 

Dapsone can cause elevated methemoglobin levels particularly in conjunction with methemoglobin‐inducing agents.
The invention discloses a non-specific receptor binding type fungus targeted antibacterial peptide and a preparation method and application thereof. The sequence of the antibacterial peptide P19 is shown in SEQ ID No. 1. The preparation method comprises the following steps: the method comprises the steps of analyzing related structural function parameters of the antibacterial peptide with activity on bacteria or fungi in a natural antibacterial peptide library by utilizing R language statistics, comparing the related parameters, screening by utilizing high-frequency amino acid composition, high-frequency charge number, hydrophobicity and structural characteristics of the antibacterial peptide of the antifungal to obtain the optimal amino acid composition, and comparing antibacterial activity and strain selectivity of each peptide chain to obtain the antibacterial peptide P19 controlled by amino acid adjusting sequence hydrophobicity and amphipathy. The antibacterial peptide is applied to the preparation of the medicines for treating fungal infectious diseases. The antibacterial peptide has a strong killing effect only on fungal strains, particularly candida albicans, has no influence on other bacterial strains, and shows accurate targeting specificity.