anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Microglia are specialized immune cells that reside in the central nervous system (CNS) and play a crucial role in maintaining the homeostasis of the brain microenvironment. While traditionally regarded as a part of the innate immune system, recent research has highlighted their role in adaptive immunity. The CNS is no longer considered an immune-privileged organ, and increasing evidence suggests bidirectional communication between the immune system and the CNS. Microglia are sensitive to systemic immune signals and can respond to systemic inflammation by producing various inflammatory cytokines and chemokines. This response is mediated by activating pattern recognition receptors (PRRs), which recognize pathogen- and danger-associated molecular patterns in the systemic circulation. The microglial response to systemic inflammation has been implicated in several neurological conditions, including depression, anxiety, and cognitive impairment. Understanding the complex interplay between microglia and systemic immunity is crucial for developing therapeutic interventions to modulate immune responses in the CNS.
Embodiments in accordance with the present disclosure are directed to blood transfer apparatuses, sleeve-puncturing assemblies, and methods thereof. An example blood transfer apparatus includes a sleeve-puncturing assembly comprising a sleeve and a hollow conduit. The sleeve is configured and arranged with longitudinal portions to be placed over or engage a blood collection container. The sleeve has an open end that engages with a portion of the blood collection container and another end that provides containment of the blood collection container while the open end is engaged with the portion of the blood collection container. The sleeve further includes a lateral portion to provide support the hollow conduit. The hollow conduit and the longitudinal portions of the sleeve engage with the blood collection container and a blood collection container to provide sufficient pressure while engaged to pull a predetermined amount of plasma or serum from the blood collection container.
High risk prescribing is the use of drugs which carry significant risk to patients. Such prescribing is not always inappropriate but does require regular review to ensure that the balance of risk and benefit in individuals is appropriate. High risk prescribing is common and varies widely between practices, and there is evidence that intensive interventions (for example, pharmacist led medication review) can reduce rates of high risk prescribing. The aim of this study is to test whether a simpler and therefore cheaper feedback intervention can reduce high risk prescribing. The study is a three arm cluster randomised trial with primary care medical practices as the unit of randomisation and outcomes measured at patient level using routinely held prescribing for individual patients. The trial will compare two forms of feedback of practice rates of high risk prescribing with usual care. Usual care matches existing NHS working practice. The first active arm will receive quarterly feedback. The second active arm will receive the same feedback plus a health psychology informed intervention designed to promote response to feedback embedded in the feedback.
PURPOSE:To obtain reconstructed liposome which can introduce a material into cytoplasm in living cells efficiently without any trouble and infection. CONSTITUTION:This reconstructed liposome comprises a modified liposome bonding to a polyethylene glycol derivative of the formula (n is a number of 25 or more, preferably.30+ or -5). The compound of the formula is obtained by synthesizing polyethylene glycol having a desired number of n and subjecting the glycol to the reaction for introducing glycerol and an alkyl of 12 carbon atoms. The incorporation of the product into liposome can be done by mixing them in a low-boiling organic solvent such as ethanol or ether at a mixing ratio of some 30/1-2/1, preferably 10/1-4/1. An appropriate material to be introduced is mixed with the reconstructed liposome synchronously, when liposome is formed, whereby the material is incorporated in. The use of said reconstructed liposome enables the smooth introduction of a material into lymphocytes which cannot incorporate such a material without difficulty.
Adolescents aged 12-18 years who continue secondary education, do not have any chronic diseases or disabilities and volunteer to participate in the study will be included. Within the scope of the project, participants' demographic data, health parameters, physical fitness, functional capacity, fatigue level, exercise behavior, system availability and satisfaction will be evaluated. All evaluations, training on the use of smart watches and mobile and web-based physical activity tracking applications will be carried out at the school where the adolescents receive education.
SENSE Theatre is a peer-mediated, theatre-based intervention targeting social competence in youth with autism spectrum disorder. The 40 hour intervention is comprised of 10 sessions in which trained typically peers are paired with children with autism spectrum disorder (ASD).
Wuling powder is composed of Alisma, Polyporus, Atractylodes, Poria, Guizhi. Take 5g each time with warm water twice a day.Take 12 weeks as a course of treatment.
BACKGROUND: Cesarean scar pregnancy, an uncommon ectopic pregnancy in which the embryo is implanted in the cesarean scar, poses significant risks without prompt diagnosis and treatment. Its prevalence has risen alongside increased cesarean section rates. Despite various treatment approaches, consensus remains elusive. Ultrasonography, particularly contrast-enhanced ultrasonography, shows promise in cesarean scar pregnancy diagnosis.
MAIN BODY: This systematic review, following PRISMA guidelines, explores contrast-enhanced ultrasound's diagnostic potential in cesarean scar pregnancy. We searched PubMed, Scopus, Web of Science, and Google Scholar up to August 2023. Selection involved two stages: title/abstract screening and full-text assessment. The included studies investigated contrast-enhanced ultrasound's diagnostic value in cesarean scar pregnancy, provided adequate data, and were peer-reviewed in English. Quality assessment followed the QUADAS-2 criteria. We extracted the diagnostic accuracy metrics: sensitivity, specificity, and accuracy. Out of 193 records, five studies met the inclusion criteria (2016-2020, China). Contrast-enhanced ultrasound displayed sensitivities of 77%-100% and specificities of 95%-100%. Two studies reported accuracy of 96.9%-97.8%. Compared with conventional ultrasound, contrast-enhanced ultrasound exhibited superior sensitivity, specificity, and accuracy. It also outperformed transvaginal ultrasound.
CONCLUSION: Enhanced-contrast ultrasound holds promise for diagnosing and managing cesarean scar pregnancy by visualizing scar vascularization in real-time, thereby reducing severe complication risks. This review highlights contrast-enhanced ultrasound as a transformative diagnostic tool for cesarean scar pregnancy management, despite existing evidence limitations.
The intervention of iTNT group is Short-course radiotherapy followed by neoadjuvant chemotherapy and PD-1 inhibitor, which consists of a short-course radiotherapy(SCRT, 5 Gy x 5 alone), then after 14 days of radiotherapy completed, four cycles of PD-1 inhibitor and four cycles of CAPOX or six cycles of mFOLFOX will be performed. The regimen of PD-1 inhibitor and CAPOX treatment includes Sintilimab 200 mg IV, day 1，Oxaliplatin 130 mg/m2 IV day 1，Capecitabine 1000 mg/m2 twice daily PO for 14 days(3 weeks per cycle). The regimen of PD-1 inhibitor and mFOLFOX treatment includes Sintilimab 200 mg IV day 1(3 weeks per cycle), Oxaliplatin 85 mg/m2 IV day 1, Leucovorin 400 mg/m2 IV day 1, 5-FU 400 mg/m2 IV bolus on day 1, then 1200 mg/m2/day x 2 days (total 2400 mg/m2 over 46-48 hours) IV continuous infusion(2 weeks per cycle), then followed by a total mesorectal excision(TME) or Watch \& Wait strategy for clinical complete remission voluntary patients.
1,139,991. Oral enzyme compositions. ARMOUR PHARMACEUTICAL CO. 18 July, 1966 [19 July, 1965], No. 32222/66. Heading A5B. A pharmaceutical composition for oral administration of enzymes comprises as the only active ingredients other than excipients at least one pancreatic enzyme and a buffer to maintain the pH of the gastric fluid between 4 and 7, which is one or more of calcium carbonate, magnesium carbonate, sodium bicabonate, sodium citrate, disodium phosphate, or dicalcium phosphate. The composition may contain inert excipients such as polyvinylpyrrolidone, magnesium stearate and lactose and may be in the form of tablets, capsules, or a powder. The enzymes may be trypsin or chymotrypsin or naturally accurring mixtures thereof, such as pancreatin.
Women with obese BMI will receive the first emergency contraception (EC) dose and complete pharmacokinetics (PK) assessments; then return to the clinic after at least 8 days to receive the second study drug and complete the same assessments. The study drugs Levonorgestrel (LNG-EC) and Ulipristal Acetate (UPA-EC) will be given in random order.
OBJECTIVES: Accurate computed tomography (CT) identification of appendicoliths in adults with acute appendicitis is crucial as it may preclude nonoperative management due to high risk of failure and complications. This investigation aimed to identify the significance of appendicoliths in acute appendicitis and to evaluate the performance of portovenous-phase (PVP) CT and the consequences of overlooked appendicoliths.
METHODS: CT examinations of 324 consecutive patients (mean age 51.9 years, 112 men) with pathologically confirmed acute appendicitis were retrospectively included. Two radiologists independently reviewed the images, and disagreement was resolved by a consensus.
RESULTS: Appendicoliths were identified in 134/324 patients, of which 75 had complicated appendicitis. Among 190 patients without appendicoliths, 52 had complicated appendicitis. An appendicolith was independently associated with complicated appendicitis (adjusted odds ratio 2.289; 95% CI: 1.343-3.902; p = 0.002). The larger minimum diameter was significantly associated with complication. The 4.5-/6.0-mm cutoffs for minimum and maximum diameters of appendicoliths demonstrated 82.7%/85.3% sensitivity and 35.6%/33.9% specificity in predicting complications. The PVP alone had 82.1-88.1% sensitivity, respectively per patient and per appendicolith, and a 100% specificity in the detection of appendicoliths, as compared with combined noncontrast and PVP. PVP overlooked 28/237 appendicoliths (11.8%) corresponding to 24/134 patients (17.9%). Of the 24 patients with overlooked appendicoliths, 16 had complicated appendicitis but 14 were correctly categorized by findings other than appendicoliths. In total, 2/127 patients (1.6%) with complicated appendicitis were misdiagnosed as having uncomplicated appendicitis.
CONCLUSIONS: Appendicoliths in acute appendicitis were strongly associated with complications. While PVP overlooked some appendicoliths, only 1.6% of complicated appendicitis were misclassified when considering other CT findings.
CLINICAL RELEVANCE STATEMENT: This study found a strong association between appendicoliths and complications. Its presence may preclude conservative management. Although portovenous-phase CT overlooked some appendicoliths, the combination with other CT findings allowed correct classification in a vast majority of cases.
KEY POINTS: • Accurate identification of appendicoliths is crucial for nonoperative management decisions in adult acute appendicitis. • Appendicoliths are strongly associated with complications in adult acute appendicitis. • Portovenous-phase CT overlooked some appendicoliths, but only a small percentage of patients with complicated appendicitis were misclassified when considering other CT findings.
BACKGROUND: Attitudes towards intellectual disability play an important role in the social inclusion and well-being of persons with intellectual disability. Few studies have examined attitudes of staff working in the specialised service industry, which may have an even greater impact. This study aimed to better understand these attitudes.
METHODS: A sample of 157 direct support professionals and 38 managers working with persons with intellectual disability completed the Attitudes Toward Intellectual Disability Questionnaire (ATTID; Morin, Rivard, et al. (2013). Journal of Intellectual Disability Research, 57, 279-292). Attitudes were assessed along affective, cognitive, and behavioural dimensions.
RESULTS: Results revealed generally positive attitudes in both groups, but more paternalistic attitudes among managers and less positive attitudes in the general population. Positive attitudes were associated with level of education, frequency and quality of contact, and knowledge about intellectual disabilities.
CONCLUSION: Workplace training programs addressing the aetiology of intellectual disability and interventions promoting self-determination may help enhance staff attitudes towards intellectual disability.
The word 'shiftwork' is commonly used to describe irregular, odd, untraditional working hours, or working hours that are away from day work period. Shiftwork dates back to the late 1800s, as applied to guardians of old kingdoms and in the military services. After the innovation of the light, shift work expanded for nonstop production as in steel factories, iron foundries, and material plants. Approximately one-fourth of the workforce in hospitals works unusual hours (away from the traditional diurnal work period) . Shiftwork has a number of advantages and disadvantages to employers, employees, and their families. The advantages for employers include optimal use of energy, facilities, and other resources through extended capital operating time. The advantages for employees include increased income, more free time for daily activities, and saving time by avoiding traffic rush hours. Shiftwork is associated with both short-term and long-term disadvantages on physical and psychophysiological health. Short-term effects include fatigue and difficulties with sleep. Difficulties with sleep are found to be the most common complaint among shift workers. Sleep disturbances were the main reasons that led shift workers to leave night shiftwork owing to disturbed health habits compared with day workers .Gastrointestinal disorders were reported 2-5 times more commonly among shift workers than daytime workers. These disorders range from minor complaints (e.g., constipation, heart burn, distension, and disturbed appetite) to serious gastrointestinal disorders, which may develop into chronic diseases such as chronic gastritis or peptic ulcers. Shiftwork has been also linked to type 2 diabetes and obesity as sleep deprivation activates the immune system and influences glucose metabolism .

An association between shiftwork and cardiovascular diseases (CVDs) has been reported. There is a higher risk for CVD such as hypertension, subclinical atherosclerosis, and ischemic heart disease compared with daytime workers . Different types of cancer have been reported in shift workers including cancers of the breast, colon, and endometrium. Shiftwork system causes circadian rhythm disruption, which is probably carcinogenic to humans.

Also, shiftwork causes disruption in both social and domestic lifestyle, which is a major consequence of shiftwork, especially with maternal employment that may have some adverse influences on their young children's cognitive and behavioral outcomes.
Participants will receive a daily oral dose of a placebo for 5 days before surgery. The daily dose will consist of 8 capsules in divided doses throughout the day.
Patients with type 2 diabetes mellitus (T2DM) have been shown to experience psychological burden and distorted illness perception. These psychological burden include feeling of burned-out, fatigue, distress and depression, and in addition of distorted illness perception often lead to difficulty in coping with the demands of life-style changes and adherence to medication. Diabetes-related distress (DRD) and depressive symptoms (DS) were associated with glycaemic control and medication adherence, and life-styles behaviors, respectively. However, evidence on the relationships between DRD, DS and clinically significant outcomes are scarce in Asian adults with T2DM. Primary care patients who participated before will be re-invited. This is a repeated cross-sectional study of a cohorts of 700 patients who were first studied in 2013 (Emotional Distress in adults with type 2 Diabetes Mellitus \& Quality of Life \[EDDMQoL\] study with the National Medical Research Register (NMRR) identification number: NMRR-12-1167-14158). Demographic data (age, gender, ethnicity, religion, educational level, occupation and monthly income), smoking status, self-perceive social support and health literacy will be collected by questionnaires.
PURPOSE:To enhance safety for skin, by using a compsn. consisting of polyhydric alcohol having at least 2 OH in one molecule, an ester carboxylic acid type anionic surfactant, and an oil phase component. CONSTITUTION:The present compsn. contains polyhydric alcohol having at least 2 OH in one molecule, an ester carboxylic acid type anionic surfactant, and an oil phase component. Said surfactant is selected from one or more compds. represented by formula I -IV in which X1 is 12-36C higher aliphatic acid residue, higher alcohol residue, alkyl aromatic residue, or steroid group; n1 is an integer of 10-60 integer; R is optionally unsatd. 1-4C alkylene optionally having OH, of di- or tri-basic acid, in the case of oxalic acid (formula V not shown) R is a simple bond; Z is an alkali metal, aliphatic amine, or basic amine acid; X2 is 12-36C higher aliphatic acid or higher alcohol; n2 is an integer of 1-30; n3 is an integer of 5-15; n4 is an integer of 1-15; and n5+n6=integer of 10- 60.
The Sperm Separation Device - ZyMōt Multi 850µL device (ZyMōt Fertility, Inc) will be used. The microfluidic chamber will be used based on the manufacturer's instructions. 850 μL of the semen sample will be added to the inlet port of the device and 750 μL of fertilization media will be added to the outlet port. The device will then be incubated in 6% CO2 at 37°C. After 30 minutes, 500 μL of the prepared sample at the outlet port will be removed and pipetted into a labelled test tube. The final volume will be adjusted to 1mL for sperm counting.
The B-cell acute lymphoblastic leukemia (ALL) cell line REH, with the t(12;21) ETV6::RUNX1 translocation, is known to have a complex karyotype defined by a series of large-scale chromosomal rearrangements. Taken from a 15-yr-old at relapse, the cell line offers a practical model for the study of pediatric B-ALL. In recent years, short- and long-read DNA and RNA sequencing have emerged as a complement to karyotyping techniques in the resolution of structural variants in an oncological context. Here, we explore the integration of long-read PacBio and Oxford Nanopore whole-genome sequencing, IsoSeq RNA sequencing, and short-read Illumina sequencing to create a detailed genomic and transcriptomic characterization of the REH cell line. Whole-genome sequencing clarified the molecular traits of disrupted ALL-associated genes including CDKN2A, PAX5, BTG1, VPREB1, and TBL1XR1, as well as the glucocorticoid receptor NR3C1 Meanwhile, transcriptome sequencing identified seven fusion genes within the genomic breakpoints. Together, our extensive whole-genome investigation makes high-quality open-source data available to the leukemia genomics community.
A preparation method for a Helicobacter pylori lipopolysaccharide outer core octasaccharide, related to the field of carbohydrate chemistry. The structure of helicobacter pylori lipopolysaccharide outer core octasaccharide is α-D-Glc-(1-3)-α-D-Glc-(1-4)-β-D-Gal-(1-7)-D-α-D-Hep[α-D-Glc-(1-6)-α-D-Glc-(1-6)-α-D-Glc-(1-2)-D-α-D-Hep]-Linker. The structure is constituted by three monosaccharides, namely glucose, galactose, and heptose. The structure comprises five glucose α glycosidic bonds, one galactose β glycosidic bond, and two heptose α glycosidic bonds. The preparation method utilizes the effect of remote neighboring group participation, the effect of a solvent, the effect of temperature, an additive, and the synergistic effect of a departing group in the preparation of the core octasaccharide. The reducing end of the octasaccharide can also be connected to a connecting arm for use in connecting with a protein to produce a glycoconjugate, for use in immunology research.
The success in treating blocked tubes may relate to the ability to dissolve the material clogging the tube as well as dealing with the thick fluid in the middle-ear. The reasoning behind this study is that the use of Pulmozyme® may be able to treat both of these problems. Pulmozyme® was approved by the FDA in 1994 for the treatment of cystic fibrosis patients. Infections present in airway (lung) secretions of cystic fibrosis patients and the material that plugs ear tubes are in some ways the same. "Off-label" use of a drug is the practice by physicians to use a FDA-approved drug in treating conditions other than what the original approval was intended for. Pulmozyme® has been used to treat other lung diseases not related to cystic fibrosis. There has been no published report on the use of Pulmozyme® to treat ear infections. This study is a clinical trial that compares two treatments and will last for 3 months.
PURPOSE:To provide a remedy composed of a vegetable juice containing alkaloid and effective to improve the circulation of blood or body fluid by applying the juice to the diseased part having insufficient circulation of the blood or body fluid, or by dipping the diseased part in the juice. CONSTITUTION:An alkaloid-containing plant is dried, cut to small pieces, and immersed in hot water to extract the alkaloid. The chilblain can be cured by dipping the hand and foot repeatedly in the extract liquid, thereby stimulating the peripheral nerve of the diseased part and promoting the blood flow, and the cold constitution can be improved by promoting the circulation of the body fluid. When the alkaloid is concentrated, it can be applied as an ointment. It is extremely convenient by sealing the agent is a handy container, discharging a proper amount of the agent from the container, and applying to the skin. It can be used also as an external drug by applying to a surface of a tape.
1. The transfer of OMNIPAQUE (Iohexol Injection) from the Pharmacy Bulk Package is restricted to a suitable work area, such as a laminar flow hood.
  2. The container closure may be penetrated only one time, utilizing a suitable transfer device and aseptic technique.
  3. The withdrawal of container contents should be accomplished without delay. However, should this not be possible, a maximum time of 8 hours from initial closure entry is permitted to complete fluid transfer operations. The container should not be removed from the aseptic area during the entire 8 hour period.
  4. The temperature of the container should not exceed 37°C, after the closure has been entered.
Patients will undergo a constant load exercise protocol with gas exchange analysis on a cycle ergometer. The exercise protocol will be consisted of repeated 6-min exercise bouts, separated by 2-min rest periods in between work bouts in order to allow application of the VitaBreath device. During the 1st min of each resting period participants will breathe either via the VitaBreath device or normally adopting the pursed lip breathing technique. During the 2nd min of each resting period participants will breathe normally and perform an IC maneuver to assess the magnitude of dynamic hyperinflation.
For 7 days, and in addition to institutional standard of care, participants will take 250 mg varespladib in the morning and in the evening. In order to maintain the blind, they will also take 1 placebo tablet in the afternoon.