anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Complicated grief (CG) is a debilitating condition that is estimated to affect millions of people in the United States alone. We conducted the first randomized controlled study to address this condition (MH60783) and confirmed efficacy of a targeted psychotherapy, complicated grief treatment (CGT). Participants in our prior study continued stable antidepressant medication while receiving CGT or Interpersonal Psychotherapy (IPT). Individuals taking antidepressants had better outcome in both treatments, though CGT was superior to IPT when administered with (60% responders v. 40%) or without (42% v.19%) antidepressants. Studies of antidepressant medication alone have shown mixed results with SSRIs appearing to be promising. However, there has been no randomized controlled study of SSRIs for CG. Determining the efficacy of SSRI treatment for CG, when administered with and without CGT, is of great public health importance.

We assembled 4 groups of investigators with strong track records in bereavement research and extensive experience with intervention studies and multicenter projects, to conduct a study of citalopram (CIT) efficacy. We plan to enroll participants with a primary diagnosis of Complicated Grief and randomly assign them (n=480; 50 at Columbia) to receive treatment with CIT, Placebo (PBO), CIT + CGT or PBO + CGT over a period of approximately 16 weeks. We want to determine whether citalopram shows a better response than placebo, when administered either with or without CGT. We will also address the question of whether CIT performs as well when administered alone as it does when administered with CGT.
<P>PROBLEM TO BE SOLVED: To provide an incense stick for quickly and readily obtaining a spicy aroma associated with roasting of fresh or dried cuttlefish.  <P>SOLUTION: A dried, powdered, processed cuttlefish product is used as a raw material of an incense stick. The incense stick preferably contains 1-30 wt.% processed cuttlefish. The spicy aroma associated with roasting of fresh or dried cuttlefish can be obtained by burning the incense stick. In addition to the dried, processed cuttlefish product, ≥10 wt.% charcoal can be compounded with the incense stick to enhance the spicy aroma associated with roasting of fresh or dried cuttlefish.  <P>COPYRIGHT: (C)2011,JPO&INPIT
The invention discloses a plaster for treating hyperhidrosis. The plaster comprises applying cloths and plaster in the middle, wherein film layers are further arranged on the applying cloths and the plaster. The plaster is prepared from the following raw materials in parts by weight: 10 parts of Chinese gall, 5 parts of white paeony root, 5-8 parts of calcined oyster shell, 5 parts of fructus schizandrae and 5 parts of astragalus. By drying and crushing the five medicines, the plaster is prepared by blending with 1 part of honey and 0.5 part of vaseline. The calcined oyster shell is obtained by calcining the oysters for two hours at 300-320 DEG C. The plaster on every applying cloth is controlled to be 7-8g in weight. Application of the plaster in treating hyperhidrosis is further provided. The plaster disclosed by the invention has the effects of converging and arresting sweating, suppressing hyperactive yang and engendering liquid, supporting sore muscles and inducing diuresis for removing edema. The plaster provided by the invention has the advantages of high cure rate, more common herbs used and low medicament price, is conveniently used, easily carried and is worth of being popularized.
The gut microbiota and inflammatory proteins may affect the development of peptic ulcer disease. However, this association remains unclear. We analyzed genome-wide association study data of gut microbiota, inflammatory proteins, and peptic ulcer disease using Mendelian randomization with instrumental variables to assess causal relationships. Various statistical methods, including inverse variance weighting, Mendelian randomization Egger regression, and sensitivity analysis were employed to evaluate the data and calculate mediation ratios. Our findings reveal that the genus Butyriciccus plays a role in mitigating the adverse effects of gastric ulcers by 7.9%, primarily through reducing beta-negative growth factor levels. Additionally, the genus Lachnospiraceae UCG004 can significantly alleviate the negative outcomes of gastric ulcers and reduces hepatocyte growth factor and beta-reserve growth factor levels by 6.39% and 7.45%, respectively. This study highlights the independent and mediating effects of the gut microbiota and inflammatory proteins on peptic ulcers, offering insights on potential pathways and targets for future preventive interventions.
The invention discloses an external application lotion for treating gynecological cervical erosion and gynecological inflammations, and a preparation method thereof. The external application lotion is prepared from the following raw materials, wherein the raw materials comprise, by weight, 40-60 parts of aconitum kusnezoffii, 20-30 parts of helleborus thibetanus franch, 20-30 parts of periploca forrestii schltr, 30-50 parts of poiret barberry root, 20-40 parts of spinyleaf pricklyash root, 30-50 parts of mahonia bealei, 20-30 parts of borneol, 0-10 parts of eucommia, 0-10 parts of honeysuckle, 0-10 parts of akabia stem and 0-10 parts of cinnamomum camphora. A plurality of natural plant drugs with effects of anti-inflammatory, detoxication, kidney-yin tonifying, congestion dissipating, impurity discharging, body resistance supporting and basis consolidating, are screened through the formula of the external application lotion. The external application lotion belongs to the filed of external application drugs, therefore the external application lotion provided by the present invention does not have any side effect. According to theoretical formulations inherited from traditional Miao medicine, the external application lotion provided by the present invention can provide a strong therapeutic effect for the gynecological cervical erosion and the gynecological inflammations. In addition, the external application lotion does not contain antibiotics and has no stimulation to human body.
Poly cystic ovarian syndrome (PCOS) is a hormonal disorder which is most common in females with fertile age. A number of small fluid filled sacs formed in ovaries which results in failure of egg release. Poly cystic ovary syndrome (PCOS) is an endocrine problem which is characterized by the polycystic ovaries, menstrual problems, infertility, metabolic disorder, psychological problems, elevated androgens, hirsutism, acne and obesity. PCOS also causes psychological disorders which include depression, anxiety, poor body image, low self-esteem and decreased health- related quality of life. Some well-controlled randomized clinical studies have been conducted to evaluate the effects of exercise training program in women with PCOS. There are many beneficial effects of exercises which improve physical fitness, body composition, and cardiovascular, hormonal, reproductive and psychological outcomes. Periodization training program involves period of active rest which allows muscle adaptations through variable intensity, volume and rest. The advantage of periodization is that it prevent from overtraining symptoms such as muscle stiffness, muscle soreness, sprain, strain, possible injury and decreased performance. High intensity interval training is effective in reducing body mass index and improving body composition in females with PCOS.

The study will be a randomized clinical trial and will be conducted in Mohsin memorial hospital Faisalabad. This study will be completed in time duration of ten months after the approval of synopsis and convenient sampling technique will be used. Total twenty four subjects will be assigned randomly by using lottery method into two groups. Group A will receive periodized resistance training and Group B will receive high intensity interval training. Warm up and cool down period of ten minutes of treadmill training will be performed by both groups. Data will be collected from all participants at baseline and after 8 weeks of treatment by using BMI and WHO-QOL BREF questionnaire. After assessing the normality data will be analyzed by using parametric or non-parametric test by using SPSS-25.
A White round pill with 25 mg of dexketoprofen will be administered 30 minutes before the impacted third molar surgery start. Immediately after the surgery, a hard-gelatin capsule with placebo will be administered.
A chamber for rotation about a rotational axis to separate blood components includes first and second spaced apart side walls forming a separation zone. Blood conveyed into the separation zone separates into a first region of cellular components, a second region of plasma, and an interface region between the first and second regions. An outlet conveys the second region of plasma from the separation zone. An interior wall extends into the separation zone to permit passage of the second region of plasma to the outlet while retarding passage of the interface region and the first region of cellular components to the outlet. The tapered second surface has a major axis that is oriented at a non-parallel angle with respect to the axis of the outlet. Due to this orientation, the boundary between the interface region and the other two regions is held uniform along the tapered surface. The boundary does not bulge to spill materials in the first interface region or interface region over the first surface and into the constricted passage. As a result, the second region of plasma is kept essentially free of other materials.
Type 2 diabetes (T2D) is a multifactorial disease with substantial genetic risk, for which the underlying biological mechanisms are not fully understood. In this study, we identified multi-ancestry T2D genetic clusters by analyzing genetic data from diverse populations in 37 published T2D genome-wide association studies representing more than 1.4 million individuals. We implemented soft clustering with 650 T2D-associated genetic variants and 110 T2D-related traits, capturing known and novel T2D clusters with distinct cardiometabolic trait associations across two independent biobanks representing diverse genetic ancestral populations (African, n = 21,906; Admixed American, n = 14,410; East Asian, n =2,422; European, n = 90,093; and South Asian, n = 1,262). The 12 genetic clusters were enriched for specific single-cell regulatory regions. Several of the polygenic scores derived from the clusters differed in distribution among ancestry groups, including a significantly higher proportion of lipodystrophy-related polygenic risk in East Asian ancestry. T2D risk was equivalent at a body mass index (BMI) of 30 kg m-2 in the European subpopulation and 24.2 (22.9-25.5) kg m-2 in the East Asian subpopulation; after adjusting for cluster-specific genetic risk, the equivalent BMI threshold increased to 28.5 (27.1-30.0) kg m-2 in the East Asian group. Thus, these multi-ancestry T2D genetic clusters encompass a broader range of biological mechanisms and provide preliminary insights to explain ancestry-associated differences in T2D risk profiles.
The role of preoperative haemoglobin as a predictor of short-term and long-term outcomes after cardiac surgery has been well established. Anaemia can impede a patient's ability to recover fully and participate in postoperative rehabilitation. It has been found that patients with a normal haemoglobin level may become anaemic during surgery. An evaluation of patients undergoing cardiac surgery, i.e. CABG, valve or combined CABG-valve procedures showed that there was a decrease in mean haemoglobin level pre-surgery two and four days after surgery. To date, no prospective randomised clinical study in cardiac surgery assessing the effect of intravenous iron supplementation in patients undergoing cardiac surgery has been reported. This prospective, randomized, placebo controlled, double blind study is planned to evaluate the effect of intravenous iron isomaltoside 1000 (Monofer®) in comparison with placebo in non-anaemic patients undergoing cardiac surgery.
gamma -Globulin is treated with pepsin or uropepsin in a neutral pH range from 6.0 to 7.5. During this there is selective breakdown of the aggregates in  gamma -globulin, whereas there is essential avoidance of any breakdown of monomeric  gamma -globulin. The resulting  gamma -globulin can be administered intravenously without adverse effects and displays no loss of opsonin activity. The therapeutic composition for intravenous injection with reduced anticomplementary activity is stabilised by adding uropepsin to human gamma -globulin. The uropepsin acts simultaneously as proteolytic enzyme and stabiliser in this case. Uropepsinogen can also be used as stabiliser.
Immune checkpoint inhibitors (ICI) have become a pillar of the oncological therapeutic arsenal. Their mechanism of action is based on the restoration of the innate anti-tumor function of T lymphocytes. This mode of action is also the cause of systemic immune-mediated adverse effects. The most common disorders are endocrine, cutaneous and gastrointestinal. The frequency of hepatic toxicities is estimated between 0.7 and 25% depending on the studies, the cancer treated and the ICI combinations used. Currently the description of these hepatitis is brief in the literature and the mechanism of toxicity is not known. Work has already compared histological damage between immune checkpoint inhibitors (CHILI) and autoimmune hepatitis; The investigators find in CHILI a higher ratio of CD8 + /CD4 + lymphocytes. Apart from these clinical, biological or histological descriptions, knowledge is limited. In particular, there are no known predictive factors or prognoses.

The investigators hypothesize that there are mechanistic differences between checkpoint inhibitors induced liver injury and idiopathic autoimmune liver disease. Proteomic analysis is a powerful tool for functional analysis.
The invention relates to a nifedipine controlled release composition, which is composed of a bilayer tablet core and a semipermeable membrane controlled release coating. The bilayer tablet core comprises a drug-containing layer and a boost layer. The drug-containing layer of the composition employs an aqueous suspension to perform granulation, and the boost layer employs an aqueous solution to perform granulation. The bilayer tablet core of the composition involves no coloring agent, and the coating film is prepared by coating solution spray. The invention also relates to a preparation method of a nifedipine controlled release tablet. The method includes: drug-containing layer granulation, boost layer granulation, bilayer tablet core preparation, coating and laser drilling. The nifedipine controlled release composition prepared by the invention has the advantages of uniform particle distribution, good tabletting effect, even content, low organic solvent residual rate and good dissolving effect, and the preparation method is simple and feasible, thus being beneficial to industrial application.
A one-session intervention with a researcher including a simple cognitive task (a memory cue, 10 minutes time gap and ca. 20 minutes of Tetris game-play) followed by instructions to engage in the task selfguided over the subsequent week. Measurements collected in a pen-and-paper diary four times a day over one week following the intervention for the primary outcome (occurrence of intrusive memories of trauma).
This study aims to compare the effects of concentric and eccentric isokinetic exercises on proprioception and muscle architecture in patients with knee osteoarthritis. 42 patients will be included in this study. Patients will be divided into three groups; concentric exercise group (n:14), eccentric exercise group (n:14) and control group (n:14). A conventional physiotherapy program and a standard therapeutic exercise program will be applied to all subjects. In addition to these exercise and physiotherapy programme, concentric and eccentric exercise groups will perform the exercises related to their groups. All three groups will participate in this program for a total of 18 sessions 3 times a week for 6 weeks. All groups will be subject to re-evaluation after 6 weeks.
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality. Here we present a large observational study on the association of COPD and exacerbations with mortality (AvoidEx Mortality).
METHODS: A real-world, observational cohort study with longitudinal analyses of German healthcare claims data in patients ≥40 years of age with a COPD diagnosis from 2011 to 2018 (n = 250,723) was conducted. Patients entered the cohort (index date) upon the first COPD diagnosis. To assess the impact of COPD on all-cause death, a propensity score-matched control group of non-COPD patients was constructed. The number and severity of exacerbations during a 12-month pre-index period were used to form subgroups. For each exacerbation subgroup the exacerbations during 12 months prior to death were analysed.
RESULTS: COPD increases the all-cause mortality risk by almost 60% (HR 1.57 (95% CI 1.55-1.59)) in comparison to matched non-COPD controls, when controlling for other baseline covariates. The cumulative risk of death after 8 years was highest in patients with a history of more than one moderate or severe exacerbation. Among all deceased COPD patients, 17.2% had experienced a severe, and 34.8% a moderate exacerbation, within 3 months preceding death. Despite increasing exacerbation rates towards death, more than the half of patients were not receiving any recommended pharmacological COPD therapy in the year before death.
CONCLUSION: Our study illustrates the impact of COPD on mortality risk and highlights the need for consequent COPD management comprising exacerbation assessment and treatment.
The invention relates to a traditional Chinese medicine preparation for curing coronary heart disease and angina which is prepared by the following raw materials according to parts by weight: 18-22 parts of salvia miltiorrhiza, 4-6 parts of Sanchi, 17-23 parts of rubefacient, 13-18 parts of dalbergia wood, 13-18 parts of rhizoma corydalis, 7-11 parts of safflower, 18-22 parts of fleece-flower root, 25-35 parts of caulis spatholobi, 18-22 parts of myrrh, 13-17 parts of ginseng, 13-17 parts of cinnamon, 18-22 parts of epimedium, 4-6 parts of hairy deerhorn, 11-15 parts of glossy ganoderma, 7-9 parts of aweto, 12-18 parts of hemlock parsley, 8-12 parts of peach kernel, 13-17 parts of olibanum, 4-6 parts of scorpion, 4-6 of chilopod, 12-17 parts of the root bark of the peony tree. The preparation has the efficacy of activating Yang and removing obstruction and eliminating phlegm for resuscitation, and is suitable for relieving obstruction of Qi in chest, thoracic pain involving the back, serious pain and tesshin, cough, plenty sputum and breathless , tachycardia. 96 cases of the coronary heat disease are cured by the invention. 85 cases among the 96 cases have obvious effect, while 11 cases have no effect. The total effective rate is 88 percent. 87 cases are followed after the medicine is stopped eating for three months, which have no recurrence.
All participants will receive instruction in the Carbohydrate-Restricted (CR) diet and basic behavioral strategies in weekly, in-person, group sessions for 3 months. The study diet has approximately 10% of kcal coming from carbohydrate, typically 50 grams/day or fewer, not including fiber. Participants will be encouraged to eat a normal amount of protein, typically about 80-100 grams/day (about 20-25% of calories), and the rest of their calories from fat.
FIELD: veterinary. SUBSTANCE: method involves the use of preparation containing, g: ichthyol 1.5-2.5; weak acid 0.03-0.07; gelatin 1.5-2.0; glycerol 3.8-4.2, and water - the rest up to 10. Suppositories were prepared from preparation which were administrated by intrauterine route after placenta removal for prophylaxis and treatment at acute catarrhal-purulent endometritis. Prevention percent of disease is 70.8% against 56% in control. Treatment period at therapeutic preparation use is decreased, recovery percent is increased up to 96%. EFFECT: increased effectiveness of treatment. 4 tbl
INTRODUCTION: Forkhead box P3 (FoxP3) transcription factor plays critical roles in controlling immune responses and cancer progression in different cancers. FoxP3 expression within the tumor microenvironment (TME) may influence clinical outcomes negatively or positively, and it could play dual roles in cancer, either by promoting or inhibiting tumor development and progression. Some studies reported that high levels of FoxP3 could be associated with tumor progression and worse prognosis, while others reported contradictory results.
AREAS COVERED: In this special report, we present a brief account on the role and function of FoxP3 in the TME, and its contribution to the clinical outcomes of cancer patients. Importantly, we give insights on the potential factors that could contribute to different clinical outcomes in cancer patients.
EXPERT OPINION: Different studies showed that FoxP3 expression can be associated with bad prognoses in cancer patients. However, FoxP3 could have opposing roles by enhancing cancer progression or regression. Location and expression of FoxP3 in T cells or tumor cells can have different impacts on cancer prognoses. Different factors should be considered to establish FoxP3 as a more robust prognostic biomarker and a potential therapeutic target for enhancing anti-tumor immunity and improving clinical outcomes of cancer patients.
Oncogenesis and progression of pancreatic ductal adenocarcinoma (PDAC) are driven by complex interactions between the neoplastic component and the tumor microenvironment, which includes immune, stromal, and parenchymal cells. In particular, most PDACs are characterized by a hypovascular and hypoxic environment that alters tumor cell behavior and limits the efficacy of chemotherapy and immunotherapy. Characterization of the spatial features of the vascular niche could advance our understanding of inter- and intratumoral heterogeneity in PDAC. In this study, we investigated the vascular microenvironment of PDAC by applying imaging mass cytometry using a 26-antibody panel on 35 regions of interest across 9 patients, capturing more than 140,000 single cells. The approach distinguished major cell types, including multiple populations of lymphoid and myeloid cells, endocrine cells, ductal cells, stromal cells, and endothelial cells. Evaluation of cellular neighborhoods identified 10 distinct spatial domains, including multiple immune and tumor-enriched environments as well as the vascular niche. Focused analysis revealed differential interactions between immune populations and the vasculature and identified distinct spatial domains wherein tumor cell proliferation occurs. Importantly, the vascular niche was closely associated with a population of CD44-expressing macrophages enriched for a proangiogenic gene signature. Taken together, this study provides insights into the spatial heterogeneity of PDAC and suggests a role for CD44-expressing macrophages in shaping the vascular niche. Significance: Imaging mass cytometry revealed that pancreatic ductal cancers are composed of 10 distinct cellular neighborhoods, including a vascular niche enriched for macrophages expressing high levels of CD44 and a proangiogenic gene signature.