anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
OBJECTIVES: Empty nose syndrome (ENS) is an underdiagnosed but burdensome clinical condition. Studies that have addressed the impact of remnant inferior turbinate volume (ITV) on ENS are scarce. We aimed to evaluate the impact of ITV and phenotyping on the severity and presentation of ENS.
METHODS: All the enrolled patients underwent the following subjective assessments: the ENS 6-Item Questionnaire (ENS6Q), Sino-Nasal Outcome Test-25 (SNOT-25), Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). The ITV was obtained from finely cut (1-mm-thick slices) sino-nasal computed tomography scan images and analyzed using ImageJ. The correlation between ITV, subjective measurements, and morphology of inferior turbinates was evaluated. ENS was categorized as torpedo type (balanced tissue volume) or pistol type (posterior dominance) based on the morphology.
RESULTS: Overall, 54 patients met the inclusion criteria. The ITV was positively correlated with the ENS6Q score and domain of ENS symptoms in SNOT-25. Neither BDI-II nor BAI scores had a significant correlation with ITV. Based on their morphological classification, the torpedo type exhibited diverse manifestations in the SNOT-25 analysis in response to changes in ITV, while the pistol type demonstrated an elevated rhinologic symptom burden and ENS-specific symptoms as their ITV increased. Nasal resistance did not correlate with the ITV in either type of ENS.
CONCLUSIONS: Symptoms were paradoxically worse in ENS patients with greater remnant ITV, and distinct morphological phenotypes in the nasal cavities may result in different presentations. Further investigation into the correlation between remnant inferior turbinates and nerve function is warranted.
LEVEL OF EVIDENCE: 3 Laryngoscope, 134:3060-3066, 2024.
A hydrogel patch is disclosed which is comprised of a polymeric material which forms a gel with water with the material being present in an amount of about 0.5 % to 40 % by weight based on the weight of the patch. Electrical conductivity of the water is increased by the addition of an electrolyte. The patch comprises an enzyme which is capable of catalyzing a reaction with a biomedically important molecule such as glucose. Glucose drawn into the patch undergoes a reaction with the aid of the enzyme and the hydrogen peroxide released flows through the electrically conductivity of the water and may react at an electrode surface to generate a signal related to the amount of glucose entering the patch. The patch is also preferably comprised of a buffer which maintains the pH of the patch in the range of from about 3 to 9, and may be further comprised of a cross-linking agent, a biocide, a humectant, and a surfactant. The patch is preferably in the form of a thin (5 µm - 50 mils), flat circular disc (0.5 to 10 cm2 of area) which will conform to the contours of human skin and may have a non-woven fabric embedded therein and removable release liners on each surface.
The invention discloses enterococcus faecalis, a micro-ecological preparation and an application of the micro-ecological preparation. The 16SrDNA sequence of enterococcus faecalis is shown in SEQ ID NO:1 and the collection number of enterococcus faecalis is CGMCC (China General Microbiological Culture Collection Center) No.6970. The micro-ecological preparation comprises enterococcus faecalis. Enterococcus faecalis is resistant to heat, acid, alkali and dryness, has strong resistance, more stable heredity and no toxicity and can suppress eight common pathogenic bacteria of pigs and cows. The micro-ecological preparation can promote sperm motility of pigs and cows and prolong the lives of pigs and cows, thus purifying the environments of genital tracts of female animals, improving and maintaining micro-ecological balance, ensuring normal physiological functions so that the female animals rut and ovulate on time and improving the fertility rate and litter size. The micro-ecological preparation has great scientific significance and good economic benefits when being applied to preventing various reproductive disturbance diseases of female animals.
The role of nanoparticle composition as biodegradable carriers for variously therapeutical drugs is disclosed. Nanoparticles are synthesized by anion emulsion polymerization of two alkyl-cyanoacrylate monomers with adjusted content ratio. By modulating the compositions, particle size, hydrophobicity and degradation rate of the copolymers is controlled. Hence, to encapsulate wide range of therapeutical drugs, poly(alkyl cyanoacrylate) nanoparticles with feasible compositions are applied individually. The copolymer nanoparticles produced by n-butyl cyanoactylate (BCA) and 2-octyl cyanoacrylate (OCA), for example, were used therein. The nanoparticles composed of poly[(n-butyl cyanoacrylate)-co-(2-octyl cyanoacrylate)] and poly(2-octyl cyanoacrylate) might be adequate for therapeutical administration.
BACKGROUND: Colonic diverticular disease is common and its incidence increases with age, with uncomplicated diverticulitis being the most common acute presentation (1). This typically results in inpatient admission, placing a significant burden on healthcare services (2). We aimed to determine the safety and effectiveness of using intravenous or oral antibiotics in the treatment of uncomplicated diverticulitis on 30-day unplanned admissions, c-reactive protein (CRP), White Cell Count (WCC), pain resolution, cessation of pain medication, return to normal nutrition, and return to normal bowel function.
METHODS: This single centre, 2-arm, parallel, 1:1, unblinded non-inferiority randomized controlled trial compared the safety and efficacy of oral antibiotics versus intravenous antibiotics in the outpatient treatment of uncomplicated colonic diverticulitis. Inclusion criteria were patients older than 18 years of age with CT proven acute uncomplicated colonic diverticulitis (Modified Hinchey Classification Stage 0-1a). Patients were randomly allocated receive either intravenous or oral antibiotics, both groups being treated in the outpatient setting with a Hospital in the Home (HITH) service. The primary outcome was the 30-day unplanned admission rate, secondary outcomes were biochemical markers, time to pain resolution, time to cessation of pain medication, time to return to normal function and time to return to normal bowel function.
RESULTS: In total 118 patients who presented with uncomplicated colonic diverticulitis were recruited into the trial. Fifty-eight participants were treated with IV antibiotics, and 60 were given oral antibiotics. We found there was no significant difference between groups with regards to 30-day unplanned admissions or inflammatory markers. There was also no significant difference with regards to time to pain resolution, cessation of pain medication use, return to normal nutrition, or return to normal bowel function.
CONCLUSION: Outpatient management of uncomplicated diverticulitis with oral antibiotics proved equally as safe and efficacious as intravenous antibiotic treatment in this randomized non-inferiority control trial.
PURPOSE: A rescue support system is provided to confirm vital sign information through a portable terminal and determine treatment and diagnosis proper for rescue. CONSTITUTION: A personal medical database(5) records person treatment data or medical insurance data. A personal vital device(10) measures a personal vital sign and records the measured vital sign information. A rescue database(15) is connected to the personal medical database to receive information recorded in the personal medical database and the vital device. A personal state calculating unit(20) compares treatment information with the vital sign information to calculate personal state supposition information. A portable terminal(25) accesses medical insurance information recorded in a rescue database, the personal state supposition information calculated in the personal state calculating unit, the vital sign information recorded in the rescue database, and the treatment information to display the same. [Reference numerals] (15) Rescue database; (5) Personal medical database
The present invention relates to a composition for expressing protein on the surface of an immune cell, which includes a cytoplasmic domain of lymphocyte activation gene-3 (LAG-3), a composition for controlling an LAG-3-related immune reaction including the same, and a composition for suppressing an immune cell activity. In addition, the present invention relates to a pharmaceutical composition for preventing or treating an immune disease including the same. Also, the present invention relates to a method for inducing an expression of protein on the surface of an immune cell using the cytoplasmic domain of the LAG-3. The cytoplasmic domain of the LAG-3 can be a core in terms of an immune control with the LAG-3 as a medium. In addition, the cytoplasmic domain of the LAG-3 can be used for a cell low signal and expression change study using a cytoplasmic domain fusion protein of the LAG-3. Besides, an activity of the LAG-3 by the cytoplasmic domain of the LAG-3 can suppress an immune activity of a T lymphocyte and a dendritic cell.
INTRODUCTION: Major depressive disorder (MDD) is associated with dysfunctional reward processing, which involves functional circuitry of the habenula (Hb) and nucleus accumbens (NAc). Since ketamine elicits rapid antidepressant and antianhedonic effects in MDD, this study sought to investigate how serial ketamine infusion (SKI) treatment modulates static and dynamic functional connectivity (FC) in Hb and NAc functional networks.
METHODS: MDD participants (n = 58, mean age = 40.7 years, female = 28) received four ketamine infusions (0.5 mg/kg) 2-3 times weekly. Resting-state functional magnetic resonance imaging (fMRI) scans and clinical assessments were collected at baseline and 24 h post-SKI. Static FC (sFC) and dynamic FC variability (dFCv) were calculated from left and right Hb and NAc seeds to all other brain regions. Changes in FC pre-to-post SKI, and correlations with changes with mood and anhedonia were examined. Comparisons of FC between patients and healthy controls (HC) at baseline (n = 55, mean age = 32.6, female = 31), and between HC assessed twice (n = 16) were conducted as follow-up analyses.
RESULTS: Following SKI, significant increases in left Hb-bilateral visual cortex FC, decreases in left Hb-left inferior parietal cortex FC, and decreases in left NAc-right cerebellum FC occurred. Decreased dFCv between left Hb and right precuneus and visual cortex, and decreased dFCv between right NAc and right visual cortex both significantly correlated with improvements in mood ratings. Decreased FC between left Hb and bilateral visual/parietal cortices as well as increased FC between left NAc and right visual/parietal cortices both significantly correlated with improvements in anhedonia. No differences were observed between HC at baseline or over time.
CONCLUSION: Subanesthetic ketamine modulates functional pathways linking the Hb and NAc with visual, parietal, and cerebellar regions in MDD. Overlapping effects between Hb and NAc functional systems were associated with ketamine's therapeutic response.
Consumption of milk proteins increase satiety and reduce glucose response when consumed alone or with carbohydrate. Milk proteins are of interest because proteins are more satiating than either carbohydrate or fat, and they regulate food intake and metabolic functions by the intact protein, encrypted peptides and amino acids on gastrointestinal and central pathways. White rice and white bread are two common carbohydrates types mostly consumed in Asia. Both of them are known to result in high glycaemic and insulinaemic responses. However, in most meals, they are accompanied by other foods such as soy milk, cow milk products. The glyceamic and insulinaemic responses are determined by the type of protein and the type of carbohydrates. And also the consumption time of protein and carbohydrate. Recent research points to an intrinsic value of small amounts of milk protein or dairy consumed shortly before a meal can reduce the glycemic response to carbohydrate and that this is not at the cost of increased demand for insulin. The objective of the present study is to investigate how glycaemic, insulinaemic and satiety responses to a white rice or white bread meal changed when a soy milk or cow milk consumed together or shortly before the meal. Whole soy milk and whole cow milk will be added to the meal. Healthy subjects (n 15) will ingest the test meals once. The meals will be provided as breakfasts, on 10 different occasions, in random order with ≥ 7 days between each. Blood samples (from the cannula and finger pricks) will be then drawn for 3 h, and glucose and serum insulin, plasma glucagon, satiety markers, inflammation markers, amino acids et.al will be analysed. The objective of the study is determining if different liquid protein consumed shortly before or with carbohydrate has different effects on metabolism. And also we will compare the difference of white rice and white bread. Determining the consuming time effect, milk protein type and carbohydrate type on glycaemic and insulinaemic are critical for the provision of dietary advice and formulation of public health guidelines.
The subjects in this group will receive the treadmill gait training. Virtual reality environment will be provided during the gait training but no feedback and interaction will be provided. Subjects in this group will receive a 30min/session, 3 sessions/week for 4 weeks, the total of 12 sessions of treadmill-based training.
The invention relates to preserved potato and a preparation method thereof. The preserved potato takes potato as material and contains 70-150 shares of potato, 50-70 shares of sucrose, 0.75-1.25 shares of sodium hydrogen sulfite, and 0.05-0.1 shares of citric acid. During manufacturing, the material is selected, washed, with peel removed, and cut with color protected; the material is taken out, rinsed in clean water, and processed by sulfur; then the material is boiled in boiling water to eighty percent cooked and is cooled with water dropped; after that, the material is preserved, boiled and dipped in sugar, dried and packed, thus obtaining the preserved potato. The manufacture process is reliable and the preserved rehmanniae can be produced by using the current production condition of the preserved fruit. The preserved potato made by the invention is sweet and delicious in taste. At the same time, the food keeps a plurality of dietary fibers, vitamins and amino acids in potato. The invention has the function of protecting stomach, keeping health, maintaining skin and beautifying features.
Development and pilot testing of the decision aid (DA) has been described previously. In brief, the DA is written at a 6th grade reading level and includes information on 1) breast cancer risk factors for women \>75 years; 2) health/life expectancy; 3) likely outcomes if screened and not screened with mammography; 4) competing mortality risks; 5) breast cancer treatments; and 6) a values clarification exercise. The last page asks users their intentions of being screened on a 15-point validated scale and invites users to share this information with their clinician. PCPs whose patients are randomized to receive the DA will be sent a copy of the DA via email and a link to an optional training on using the DA (5 informational slides and a 3-minute video).
MRI scans will be performed at three time points. The time points will be 1-2 weeks prior to the start of treatment, between 4 and 5 weeks after the start of treatment (i.e., after the 20th radiation treatment fraction and before the start of the 25th radiation treatment fraction), and 3-4 months after the completion of chemoRT. Scans acquired at the first and third time points will be clinically indicated (except for the spectroscopy scan) and ordered by the treating physician. The scan session corresponding to the second time point will be for research purposes. The investigators chose 4-5 weeks as the time point for predicting early response to chemoRT for the following reason. In a 7-week treatment regimen, an indicator tested at \> 5 weeks would have limited predictive utility in the consideration of an alternative therapy, i.e., surgical intervention. However, an indicator measured at \<= 5 weeks (i.e., with enough time remaining to the end of therapy) might potentially inform the therapeutic course of action in future studies. If this pilot study demonstrates utility of advanced MR imaging techniques identified at 4-5 weeks, future studies could focus on the optimal timing for assessment of early response. The time point of 3-4 months is selected for assessing post-therapy response because it coincides with the clinical follow-up schedule (at which an image-based assessment of response is performed via a clinical exam and/or PET imaging) that determines the standard of care response.

T1, T2, and T2\* MRI scans will be performed to delineate head and neck tissues. DCE MRI scans will provide quantitative assessment of contrast uptake in tissues and tissue vasculature both during and at follow-up after completion of chemoRT. Contrast on images will be provided by a gadolinium-based contrast agent (GBCA). GBCA is FDA-approved and is routinely used in dynamic contrast-enhanced MRI scans. Further, contrast enhanced MRI is typically obtained on all cancer patients including head and neck cancer as part of routine clinical care. Diffusion MRI scans will provide information on the diffusion of water molecules in tumor, nodes and other head and neck tissues. MR spectroscopy scans will provide information on tissue metabolites. All scans acquired prior to the start of chemoRT will provide baseline maps against which functional maps acquired during and after completion of chemoRT will be compared to determine the relative change in anatomical, biophysical and biochemical parameters.

Image anatomy and parameter maps will be correlated with dose maps derived from CT images by registering (fusing) MRI images with CT images acquired as part of standard of care and used for treatment planning of the subject's radiation treatment.
1,209,201. Cardiac preparations. LES LABORATOIRES ALBERT ROLLAND. 17 April, 1968 [17 April. 1967], No. 18192/68. Heading A5B.  Myocardiotic pharmaceutical compositions comprise a despecified heart extract and one or more of (a) adenosine triphosphoric acid or a pharmaceutically acceptable salt thereof, e.g. the disodium or dipotassium salt; (b) aspartic acid or a pharmaceutically acceptable salt thereof, e.g. Na, K or Mg salts; and (c) vitamin B 6 . The compositions may be prepared by mixing the said ingredients at 5 to 10C in solution in physiological saline and lyophilizing the mixture, preferably at -80C. under a pressure of 10<SP>-4</SP> mm. Hg. The compositions may be formulated in forms for oral, parenteral or arterial perfusion administration comprising suitable excipients. The extract may be a whole heart or a nodal tissue extract. The despicified heart extract is prepared by freezing to -78 C. fresh heart and despecifying at 5 to 10C. for example by treatment with Ca ion activated trysin at pH 8 followed by lowering the pH to 3.7 with sulphuric acid, neutralising to pH 9 by adding barium or calcium hydroxide, filtering the precipitate formed and lyophilizing the filtrate.
This arm consist on 3 month on Bdiet with high energy and protein breakfast (660 +/-20 kcal), medium sized lunch (580+/-20 kcal) and dinner reduced in energy (300+/-20 kcal), with distribution of calories: breakfast 44%, lunch 37% and dinner 19%. The breakfast will contain 38 g protein mostly from milk and dairy products.
Dermal fillers have been approved for the treatment of age related aesthetic changes, including facial volume loss, and attenuation of the static and dynamic rhytid. Despite widespread use of volumizing fillers there is little data quantifying the subjective benefit of these minimally invasive treatments from the patient perspective. Furthermore, there is little data comparing the subjective benefit with true objective volumetric results. Such data will provide much needed information for patient counselling and treatment optimization for patient perceived outcomes.

This study is to determine the patient reported outcomes of three different dermal fillers and establish the volumetric changes over 90 days. Screening will be performed during the patient's office visit. Approximately 100 patients will be enrolled. Patients will participate up to 90 days (Day 1, 14 days, 28 days, and 90 days).
Procedure for obtaining an isolated tannic extract of grape, obtained tannic extract and its uses. A method for obtaining an isolated tannic extract of grape from grape seeds is provided. The procedure comprises: preparation of grape seeds as source of tannins; preparing an aqueous solution of a polyphenol solubilizing agent selected from urea, a compound containing the group so3 and sodium hydroxide at a concentration of 1% to 15% by weight; in an autoclave reactor, carry out a single extraction; separation and direct concentration to give the isolated extract. The invention also relates to the obtained tannic extract. The new tannic extract isolated from grape seeds comprises a mixture of tannins and non-tannins, whose composition provides the extract with improved antioxidant and light fastness properties. The tannic extract isolated from grape seeds also comprises a dye. (Machine-translation by Google Translate, not legally binding)
Pregnant women who meet the inclusion criteria assigned to the Oketani Massage group will be informed about the study and their written and verbal consent will be obtained. Pregnant women will be asked to fill out the 'Introductory Characteristics Information Form' and 'Prenatal Breastfeeding Self-Efficacy Scale Short Form' at the first meeting before the training and then they will be given breastfeeding training and massage prepared with the Oketani method. 2 weeks after the training, the researcher will apply Oketani breast massage twice before the mother enters the operating room and once before the mother's first breastfeeding in the operating room or in the ward. One day after birth, they will be asked to answer the Postpartum Breastfeeding Self-Efficacy Scale Short Form, LACTH and Visual Comparison Scale Satisfaction (VAS-S) scale.
OBJECTIVES: This study aimed to perform a systematic review and meta-analysis on the efficacy of empirical high-dose radioiodine therapy in treating differentiated thyroid cancer patients with thyroglobulin (Tg)-elevated negative iodine scintigraphy (TENIS) syndrome.
METHODS: We searched PubMed, EMBASE, and the Cochrane Library to identify relevant studies published until April 2022. This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist and registered in an international prospective register of systematic reviews (PROSPERO). Meta-analyses of proportions and odds ratios were performed to assess the beneficial effect of empirical high-dose radioiodine therapy in patients with TENIS syndrome. Subgroup analysis was also performed according to the presence of micrometastasis or macrometastasis.
RESULTS: We identified 14 studies including 690 patients who received empirical high-dose radioiodine therapy for TENIS syndrome. Those who had micrometastasis exhibited additional lesions not previously observed on diagnostic whole-body scan (prop = 0.64, 95% confidence interval [CI], 0.51-0.77) and had reduced serum Tg levels (prop = 0.69; 95% CI, 0.52-0.84) after empirical radioiodine treatment. No such findings were observed among patients with macrometastasis. Moreover, we found that the empirical radioiodine treatment group had lower serum Tg levels than did controls (odds ratio = 0.27; 95% CI, 0.09-0.87), which suggests a lower risk of disease progression.
CONCLUSIONS: Our findings indicate that empirical high-dose radioiodine therapy promoted beneficial effects and could be recommended for patients with TENIS syndrome, especially those with micrometastasis.