anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a near-infrared fluorescent nanoparticle in-vivo probe. The near-infrared fluorescent nanoparticle in-vivo probe comprises water-soluble near-infrared CdHgTe fluorescent quantum dots and liposomal phospholipid film wrapped outside the dots. The invention further provides a preparation method of the near-infrared fluorescent nanoparticle in-vivo probe. The preparation method includes the steps of firstly, synthetizing the water-soluble near-infrared CdHgTe fluorescent quantum dots; secondly, preparing the liposomal phospholipid film; and thirdly, adding water-soluble near-infrared fluorescent quantum dots CdHgTe solution synthetized in the step 1 into the liposomal phospholipid film prepared in the step 2 to obtain the near-infrared fluorescent nanoparticle in-vivo probe. The near-infrared fluorescent nanoparticle in-vivo probe is high in stability and biocompatibility. The preparation process is simple, the cost is low, and the near-infrared fluorescent nanoparticle in-vivo probe is convenient to use and effective in in-vivo imaging.
From study inception until March 2014, the investigators conducted a multi-site randomized controlled trial (RCT) comparing the effectiveness of ankle arthrodesis and ankle arthroplasty over a 2-year follow-up period. The study used a modified Comprehensive Cohort Design. Subjects unwilling to randomize to surgery could still participate in the study by entering into the preference cohort and select surgery in consultation with their surgeon.

By March 2014, no subjects had entered into the randomized cohort. The Data and Safety Monitoring Board (DSMB) recommended stopping recruitment in the randomized arm of the study since no subjects were willing to randomize to surgery. All patients were enrolled in the preference cohort and selected arthrodesis or arthroplasty. Despite the change in study design, the objectives remain unchanged.
Major depression is a common and serious mental illness. It is associated with a markedly lower quality of life, significant functional impairment, and premature death due to suicide or comorbid physical illness. Over the past 50 years, effective and safe treatments for major depression have been developed, including antidepressant pharmacotherapy, psychotherapy, and electroconvulsive therapy. However, many Americans who suffer from a depressive disorder either do not elect to receive one of these conventional treatments or do not complete an adequate course of treatment. A growing number of Americans with depression are choosing to be treated with complementary and alternative therapies. Acupuncture, in particular, is increasingly being used to treat depression even though only limited data support its safety and efficacy.

This study will use a randomized parallel-group design to compare the safety, efficacy, and tolerability of electroacupuncture (EA) and sham electroacupuncture (SA) for the treatment of major depression. Over a 15-month period, 60 adult outpatients with a major depressive disorder of mild or moderate severity (as defined by the DSM-IV) will be randomized to either 12 sessions of EA or SA to be provided over 6 weeks. Safety and symptomatic improvement (as measured with the Hamilton Rating Scale for Depression \[HRSD\]) will constitute the primary outcome measures. Tolerability and functional improvement will constitute secondary outcome measures.
To determine the clinical efficacy of Zuqing Xu 'Wuduling' powder for snake injury on the swelling of the affected limb bitten by Agkistrodon halys. Sixty-five patients with Agkistrodon halys bite were assigned to a treatment group (n = 35) or control group (n = 30). The treatment group was additionally given 'Wuduling' powder dressing locally based on the therapy to the control group with conventional Western medicine. Clinical efficacy and improvement of traditional Chinese medicine symptoms and signs in the two groups were evaluated. The treatment group showed a notably higher cure rate than the control group. After 3 days of therapy, the swelling and pain of the affected limb in the treatment group were greatly alleviated. Additionally, after 7 days of therapy, the swelling and pain of the affected limb in the treatment group were more greatly alleviated, and those in the control group were also alleviated. The comparison of the two groups during the same period showed more obvious alleviation of swelling and pain in the treatment group than that in the other. Moreover, the treatment group experienced notably shorter disappearing time of swelling and pain than the control group. After treatment, the levels of CRP, TBIL, Cr, ALT, AST, BUN, CK, LDH and CK-MB in both groups declined notably, with notably lower levels of them in the treatment group than those in the other. Zuqing Xu 'Wuduling' powder for snake injury can substantially alleviate the swelling and local pain of affected limbs bitten by Agkistrodon halys.
A process for obtaining beta-glucan from cereal by extracting with water and without deactivation of enzymes associated with the cereal. A process for controlling the average molecular weight of beta-glucan extracted from cereal by controlling the extraction time. A process for recovering beta-glucan from an aqueous solution of beta-glucan comprising freezing the solution, allowing the solution to thaw and separating solids from the resultant suspension. A beta-glucan produced by any of these processes. A beta-glucan which forms a gel when a heated solution of the beta-glucan cools. The use of beta-glucan in treating various health disorders, as an additive in cosmetics and foods, and as a film forming agent. A cereal from which beta-glucan has been extracted for use as animal feed or in brewing processes.
All participants must be diagnosed with rheumatic disease (connective tissue disease (CTD)) and intestinal lung disease (ILD) and fulfil all inclusion and no exclusion criteria. Information about participants will be obtained from electronic and physical medical records for existing data collection (over the past ten years, from 2012 to 2022) and/or from medical consultations for newly collected data (for the next three years, from 2023 to 2026). The participants' observation time varies and can be over the whole study duration (from 2012 to 2023), over the past ten years only (existing data) or over the next three years (new data).
FIELD: medicinal biotechnology, medicinal biochemistry. SUBSTANCE: invention relates to peptides and peptide analogues that simulate structural and pharmacological properties of human apolipoprotein (ApoA- 1). Peptides and peptide analogues represent amino acid sequences and multimeric complexes with lipids that can be used for treatment of different diseases associated with dyslipidemia. Invention describes pharmaceutical compositions and methods for treatment based on simulating agents of ApoA-1. EFFECT: valuable medicinal properties of agonists, expanded assortment of agents for control of dyslipidemia. 52 cl, 10 tbl, 8 dwg, 12 ex
Exercise-Induced Bronchospasm (EIB) affects between 7-30% of highly trained athletes. The first phase of this study is to screen varsity level college athletes for EIB using Eucapnic hyperventilation (EVH). Those athletes who screen positive, will be enrolled in phase two, a randomized double-blinded placebo controlled double crossover study. At enrollment, athletes will undergo a cardiopulmonary stress test (CPST) and induced sputum sampling and will then be prescribed daily montelukast/placebo for a three week period. Athletes will return after three weeks and repeat the EVH, CPST, and induced sputum. They will then have a one week washout period followed by crossover once again to daily montelukast/placebo for another three weeks. After the second three weeks they will once again return for a final EVH, CPST, and induced sputum. The goal of this study is to demonstrate that effectively blunting the EIB response with montelukast, indices of ventilation,exercise tolerance, and perhaps overall physical fitness improve, allowing athletes to train more effectively, in a nonergogenic manner.
Inflamed patients admitted to the intensive care unit after cardiac surgery received large volumes of crystalloid fluids as standard care procedure. The goal is to control the balance between the initial pro-inflammatory phase and the subsequent/compensatory anti-inflammatory phase, the later being associated to immune fatigue and the apparition or re-activation of infections. Infectious complications are responsible for the increased rate of morbidity and mortality in this cardiac surgery population. The inflammatory impacts of each of the crystalloid fluids administered to the patient are still ill-defined and represent an opportunity to better control the hyperinflammation and/or immunosuppression often observed following cardiac surgery. Hence, the investigators will evaluate the activation of the immune system following crystalloid fluid (either Normal saline (NS), PlasmaLyte (PL) or Ringer's Lactate (RL)) administration in this population with regard to one recurrent clinical issue, i.e renal failure.

The hypothesis is that LR is less ''immuno-activator'' on monocytes than NS and PL. The objectives are: 1-evaluate the inflammatory profiles of each of the crystalloid fluids in consent cardiac surgery patients during their stay in the intensive care unit by studying white blood cell phenotypes and inflammatory cytokines present in plasma and 2-evaluate the impacts of crystalloid fluids in vitro using white blood cell from cardiac surgery patients obtained before surgery.
A single intravenous injection of sodium chlorid (9 mg/mL). Dose: the same volume as the volume given/to be given with GnRH, that is maximal dose = 1 mL = 9 mg sodium chlorid.
PCT No. PCT/EP90/00719 Sec. 371 Date Sep. 26, 1991 Sec. 102(e) Date Sep. 26, 1991 PCT Filed May 4, 1990 PCT Pub. No. WO90/13575 PCT Pub. Date Nov. 15, 1990.Novel proteins which have a molecular weight of about 42,000 daltons and have at the N terminus the amino acid sequence Xaa Thr Pro Tyr Ala Pro Glu Pro Gly Set Thr Cys Arg Leu Arg Glu where X is hydrogen, a phenylalanine residue (Phe) or the amino acid sequences Ala Phe, Val Ala Phe, Gln Val Ala Phe, Ala Gln Val Ala Phe, Pro Ala Gln Val Ala Phe or Leu Pro Ala Gln Val Ala Phe, and which are suitable for the treatment of diseases, are described.
This prospective single center study is performed at the university children's Hospital zurich. Patients planned for surgery in general anesthesia with intubation, aged 0 to 16 years and with a body length suitable for the emergency tapes can be included in this study. Patient and parental information is performed during the pre-anesthetic visit. After written consent the patient will be included. Patient ́s length and weight will be measures earliest one day before data collection. Data collection during anesthesia has no influence on the daily anesthesia routine and has no impact on patient safety and anaesthesia. Patient's data is made anonymous for further inspection. Data is documented in Microsoft Excel and statistical analysis calculated with SPSS. 1000 patients are needed for a power of 80%. Primary outcome parameter is length based weight estimation, secondary outcome parameters are length based age estimation and the correctness of recommended anesthesia material (endotracheal tube, laryngeal mask, oropharyngeal mask and face mask). Both tools (program and anesthesia tape \["Anästhesie-Lineal"\]) will be compared with each other regarding primary and secondary outcome parameters.
The collaborators will design the Community-based education approach (based on the core intervention package). Collaborators will be required to submit a brief standardized proposal to the academic investigators for review and approval, to ensure that all intervention programs have the same core intervention content and can be implemented appropriately. Collaborators will be able to use any reasonable strategies, such as social media platforms, information technology, posters, leaflets, and videos, to implement the programs . The use of incentives will be encouraged to improve participation. Each programs will last for 3 months. A booster session will be conducted at the mid of the intervention.
PURPOSE: Chemotherapy-induced diarrhoea (CID) and constipation (CIC) are among the most common and severe gastrointestinal symptoms related to chemotherapy. This review aimed to identify and describe the evidence for non-pharmacological interventions for the management of CID and CIC.
METHODS: The scoping review was based on the Joanna Briggs Institute methodology and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews checklist. Evidence from five databases were included: CINAHL, MEDLINE, Embase, PubMed, and APA PsycInfo. Data were systematically identified, screened, extracted and synthesised narratively to describe the evidence for non-pharmacological interventions and their effects on CID and CIC.
RESULTS: We included 33 studies, of which 18 investigated non-pharmacological interventions for CID management, six for CIC management, and nine for both CID and CIC management. Interventions were categorized into five groups, including (1) digital health interventions, (2) physical therapies, (3) diet and nutrition therapies, (4) education, and (5) multimodal. Diet and nutrition therapies were the most common to report potential effectiveness for CID and CIC outcomes. Most of the interventions were implemented in hospitals under the supervision of healthcare professionals and were investigated in randomised control trials.
CONCLUSIONS: The characteristics of non-pharmacological interventions were diverse, and the outcomes were inconsistent among the same type of interventions. Diet and nutritional interventions show promise but further research is needed to better understand their role and to contribute to the evidence base. Nurses are well placed to assess and monitor for CIC and CID, and also deliver effective non-pharmacological interventions.
PROBLEM TO BE SOLVED: To obtain a composition having a form of compact powder capable of being stably preserved, having good adhesiveness and impact resistance with smooth and without fatty feelings by bringing the composition to contain a fat phase and a powdery phase comprising two different types of fillers. SOLUTION: This cosmetic composition having a form of compact powder and useful for makeup products contains 2-98 wt.% of a fat phase and 2-98 wt.% of a powdery phase. The powdery phase contains a noncompressible first phase and a second phase. The fillers are selected from fillers of inorganic lamellar form, organic lamellar form, inorganic spherical form and organic spherical form and the first filler and the second filler are different to each other. The powdery phase is brought to contain 1-100 wt.% of the noncompressible filler, 0-99 wt.% of the compressible filler and 0-50 wt.% of a pigment. The composition is prepared by preparing an oil-in-water emulsion of the fat phase in a water phase, dispersing the powdery phase in the emulsion, poring the obtained dispersion into a form and freezing and drying it.
Cisplatin is a potent compound in anti-tumor chemotherapy; however, its clinical utility is hampered by dose-limiting nephrotoxicity. This study investigated whether papaverine could mitigate cisplatin-induced kidney damage while preserving its chemotherapeutic efficacy. Integrative bioinformatics analysis predicted papaverine modulation of the mechanistic pathways related to cisplatin renal toxicity; notably, mitogen-activated protein kinase 1 (MAPK1) signaling. We validated protective effects in normal kidney cells without interfering with cisplatin cytotoxicity on a cancer cell line. Concurrent in vivo administration of papaverine alongside cisplatin in rats prevented elevations in nephrotoxicity markers, including serum creatinine, blood urea nitrogen, and renal oxidative stress markers (malondialdehyde, inducible nitric oxide synthase (iNOS), and pro-inflammatory cytokines), as tumor necrosis factor alpha (TNF-α), monocyte chemoattractant protein 1 (MCP-1), and interleukin-6 (IL-6). Papaverine also reduced apoptosis markers such as Bcl2 and Bcl-2-associated X protein (Bax) and kidney injury molecule-1 (KIM-1), and histological damage. In addition, it upregulates antioxidant enzymes like catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx) while boosting anti-inflammatory signaling interleukin-10 (IL-10). These effects were underlined by the ability of Papaverine to downregulate MAPK-1 expression. Overall, these findings show papaverine could protect against cisplatin kidney damage without reducing its cytotoxic activity. Further research would allow the transition of these results to clinical practice.
The objective of the study is to determine the effects of plyometric training versus explosive strength training on agility, power, and dynamic balance in basketball players. The study is randomized and single-blinded. Ethical approval is taken from the Ethical Committee of Riphah International University, Lahore. Participants who meet the inclusion criteria will be enrolled and allocated in groups A \& B through the sealed envelope method by Non-probability Convenient random sampling technique. Subjects in group A will receive plyometric training. Group B will receive explosive strength training. The outcome measures will be assessed by agility T-test, vertical jump test, and star excursion balance test (SEBT).

The data will be analyzed by SPSS, version 25. Statistical significance is p=0.05.
The name of the invention is an artemisia leaf glutinous rice cake and aprepration method, belonging to the glutinous rice cake food technical field. The invention mainly solves the problem that artemisia leaf is not capable of being added directly to glutinous rice cake to be eaten. The invention has the main characteristics that: the manufacturing materials contain sticky rice and artemisia leaf; the sticky rice is 56 to 66 and the artemisia leaf is 37 to 41. the preparation method for artemisia leaf glutinous rice cake is that: {1}the clean-washed tender green artemisia leaf is put into boiling water containing dietary alkali, with a viscosity of 4 percent to 6 percent, and is stewed for five to eight minutes and then the leaf base is removed after being cooled to 40 DEG C to 48 DEG C; {2}the sticky rice is grinded into powder after being soaked in the water for five to eight hours;{3}the dietary alkali water, with a viscosity of 2 percent, is added into the sticky water and the artemisia leaf and is mixed evenly, cut into pieces and grained completely, and then becomes a paste;{4}the paste is changed into an oblate shape or stuffings are wrapped into the paste in an oblate shape;{5}the oblate-shaped paste is covered with big bamboo leaves and tender tug oil tree leaves and is steamed in a steam box. The invention mainly provides the artemisia leaf glutinous rice cake and the preparation method. The taste of the artemisia leaf glutinous rice cake is soft and smooth. Besides, the artemisia leaf glutinous rice cake has the health care function.
FIELD: cosmetics, polymers, dyes. SUBSTANCE: invention relates to anhydrous compositions for decolorization of keratin fibers, in part, human keratin fibers. Composition comprises at least one alkaline agent and at least one peroxide salt, and at least one water-soluble thickening agent in common with at least non-ionic amphiphilic polymer containing at least one aliphatic chain in medium useful for decolorization and ready for application. Method involves mixing of components with hydrogen peroxide aqueous composition. Invention relates also to method of hair decolorization using these anhydrous compositions and to kit for decolorization of keratin fibers, in part, human keratin fibers. Anhydrous decolorizing compositions comprise thickening system that provides the improved maintenance of viscosity of decolorizing compositions for all time necessary for realization of required decolorization. EFFECT: improved method of decolorization, valuable properties of composition. 24 cl, 2 tbl, 2 ex
General anesthesia using target-controlled infusion of intravenous propofol and remifentanil. Propofol will be adjusted maintaining the BIS between 40-60 until the end of surgery.
QT prolongation and the potentially fatal arrhythmia Torsades de Pointes are common causes for withdrawing or restricting drugs; however, little is known about similar liabilities of environmental chemicals. Current in vitro-in silico models for testing proarrhythmic liabilities, using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM), provide an opportunity to address this data gap. These methods are still low- to medium-throughput and not suitable for testing the tens of thousands of chemicals in commerce. We hypothesized that combining high-throughput population- based in vitro testing in hiPSC-CMs with a fully in silico data analysis workflow can offer sensitive and specific predictions of proarrhythmic potential. We calibrated the model with a published hiPSC-CM dataset of drugs known to be positive or negative for proarrhythmia and tested its performance using internal cross-validation and external validation. Additionally, we used computational down-sampling to examine three study designs for hiPSC-CM data: one replicate of one donor, five replicates of one donor, and one replicate of a population of five donors. We found that the population of five donors had the best performance for predicting proarrhythmic potential. The resulting model was then applied to predict the proarrhythmic potential of environmental chemicals, additionally characterizing risk through margin of exposure (MOE) calculations. Out of over 900 environmental chemicals tested, over 150 were predicted to have proarrhythmic potential, but only seven chemicals had a MOE < 1. We conclude that a high-throughput in vitro-in silico approach using population-based hiPSC-CM testing provides a reasonable strategy to screen environmental chemicals for proarrhythmic potential.
FIELD: medicine, oncology. SUBSTANCE: the present innovation deals with treating non-Hodgkin's lymphomas and granulomatosis. On the 1st and 8th d of therapy it is suggested to carry out plasmapheresis, sample autoplasma at the quantity of 200-250 ml, conduct chemotherapy course: vincristine 1 mg, doxorubicin 40-50 mg, cyclophosphan 600-800 mg; cytostatics should be mixed with autoplasma, incubated at 37 C for 1 h and reinfused for a patient. Therapy should be performed at the background of prednisolone application at the dosage of 40 mg/d from the 1st till 14th d either inside or intramuscularly. EFFECT: higher efficiency of therapy. 2 ex
If the student attends a school that has been randomized to SPI alone, youth will be asked to participate in a collaborative approach to create a stepwise safety plan that includes a simple list of individually tailored, concrete coping mechanisms to be enacted during or leading up to a crisis. The seven steps of the safety plan include: 1) recognizing warning signs of a crisis; 2) employing internal coping strategies; 3) using social contacts and settings to distract from suicidal thoughts; 4) seeking help from family members or close friends; 5) contacting healthcare or emergency services; 6) identifying reasons for living; and 7) reducing access to means. Youth will be followed-up at 2- and 4-weeks post intake to assess suicide risk and review their safety plan.