anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To easily execute analysis of many terms in a short period with high accuracy by separately analyzing the prescribed respective plural materials in a sample in accordance with the information on the grain size of a carrier detected from a reactive liquid of plural immune complexes and the remaining labeling antibody. CONSTITUTION:The reactive liquid of the plural immune complexes and remaining labeling antibody is introduced through a needle 22 into a flow cell 21. Laser light 24 is irradiated on the respective immune complexes and remaining labeling antibody flowing in the needle 22. The size of each immune complex is measured by a detector 25 and the fluorescent quantity /1 latex riding on each latex is measured by a detector 26. A sightgram is obtd. by these two parameters. The recognition of the size of the immune complexes by each antigen is thus made possible by using the flow sight meter and the latex immunoassay using the latexes of different grain sizes carrying the antibodies as the solid phase according to the respective antigens. The simultaneous measurement of the antigen concn. of multiple terms is thereby made possible without the sepn. (B-F sepn.) of the immune complex and the remaining labeling antibody.
Disclosed are methods for reducing the astringency of dentifrice composition containing stannous comprising administering to the subject a dentifrice composition comprising stannous. The dentifrice composition comprises stannous ions, poloxamer, and aqueous carriers. The efficacy of this dentifrice composition containing stannous will not be reduced by the poloxamer. The dentifrice composition may also contain a polyphosphate as long as the water content is limited and the stannous ion is not provided from stannous fluoride. The polyphosphate will also not reduce the efficacy of the stannous. Alternatively, the dentifrice composition may be a dual phase composition. The first dentifrice composition will contain a polyphosphate having an average chain length of about 4 or more and have a limited water content while the second dentifrice composition will contain stannous ions. In the dual phase compisition, the poloxamer will be present in the first or second dentifrice compositions or both compositions. Neither the polyphosphate or the poloxamer will reduce the efficacy of the stannous.
Use of application Proloquo2Go on iPad device. The application being used is called Proloquo2Go which is the intervention portion. The iPad is the device used to access the application.
A total of 36 patients between the ages of 40 and 75 who were diagnosed with Kellgren-Lawrence Stage II and III knee OA by the physician were included in the study. Participants were divided into two groups as static stretching group (n = 18) or PNF stretching group (n = 18). Patients' demographic and clinical information was recorded. Pain intensity was evaluated with visual pain scale, hamstring flexibility with Active Knee Extension Test, functional status with Western Ontario and McMasters University Osteoarthritis Index and Timed Get Up and Go Test. In addition to the standard physiotherapy program, the subjects praticed stretching exercises for 15 sessions according to the groups that they've been separated. Evaluations were repeated in the end of the treatment (4th week) and in the 3rd month after the treatment.
The present invention relates to an antithrombotic composition containing an extract of Zingiber officinale sprouts as an active ingredient. More specifically, the present invention relates to a pharmaceutical composition and a health functional food for preventing, treating, or alleviating thrombosis through inhibition of blood coagulation and inhibition of platelet aggregation, wherein the pharmaceutical composition and the health functional food contain an extract of Zingiber officinale sprouts as an active ingredient. As demonstrated in embodiments of the present specification, an extract of Zingiber officinale sprouts as an active ingredient of a pharmaceutical composition and a health functional food for preventing or treating thrombosis of the present invention concentration-dependently exhibits a strong antithrombotic activity secured by inhibition of thrombus production-related enzymes, inhibition of blood coagulation factors, and inhibition of human platelet aggregation. At the same time, since the extract of Zingiber officinale sprouts does not show a hemolytic activity for human erythrocytes at all, has excellent thermal stability, and does not show a loss of inhibition effects of thrombus production-related enzymes and blood coagulation factors even in plasma and acidic conditions of pH 2, the extract is expected to be used to prevent and treat thrombosis, such as ischemic stroke and hemorrhagic stroke, through improvement of blood circulation. The active ingredient has an excellent effect of being processed in various forms, such as an extract, a powder, a pill, a tablet, or the like, to be prepared in a form which can be taken anytime, and thus is very useful in the pharmaceutical industry and the food industry. Since sprouts generated during storage of ginger is used, it is possible to contribute to reuse of discarded resources and environmental preservation.
The speech function is a multidirectional process that depends on complex neuro-muscular network. The function can be evaluated using instrumental, such as voice analysis computer programmes, scales, or well structured questionnaires. There are many scales for assessment of perceptual speech but there is no validated for head and neck patients. The study will assess the construct validity and adaptation of the Turkish translation of Speech Specific Perceptual Speech Evaluation as known as London Speech Evaluation Scale. The investigators developed the Turkish translation of this scale (LSE-T), according to the cross-cultural adaptation guidelines. Two translators translated the LSE into Turkish and a native English language speaker reverse-translated it into English. The back translation was sent to the original author for proofreading. The LSE scale consisted of 6 parameters and 4 scores related with perceptual speech in head and neck cancer patients.
Arm A participants will receive 16 mg of CYB003 in 2 of 2 medicine sessions, approximately three weeks apart. All Arm A participants will continue on their current antidepressants and receive psychological support throughout the study.
BACKGROUND: Various factors, including dietary habits, lifestyle choices, socio-economic status, cultural attitudes, academic stress, and access to mental health support services, influence the relationship between obesity and mental health among university students in Gulf Cooperation Council (GCC) countries. Understanding these complex interactions is crucial for developing effective interventions to promote both physical and mental well-being among students in the region. Therefore, this systematic review aims at understanding the variables associated with the relationship between obesity and mental health among university students in the (GCC) countries.
METHODS: This systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) [CRD42024517806]. We conducted a systematic literature search using electronic databases including PubMed, PsycINFO, Scopus, CINAHL, Web of Science, and Google Scholar to identify relevant studies published up to 28-February-2024. A narrative synthesis approach was employed to summarize the findings of included studies. Data were synthesized according to predefined themes related to variables associated with the relationship between obesity and mental health among university students in GCC countries.
RESULTS: The prevalence of overweight and obesity among university students in GCC countries is alarmingly high, with a mean rate of 29.4%. Depression, anxiety, and body image dissatisfaction are significantly associated with obesity in this population. Poor sleep patterns are both a predictor and a consequence of obesity-related mental health issues. Socio-cultural factors play a crucial role in shaping students' perceptions of body image and mental health.
CONCLUSION: These findings highlight the importance of comprehensive approaches to address the intertwined nature of obesity and mental health in this population, necessitating targeted interventions and further research efforts.
BACKGROUND AND HYPOTHESIS: Schizophrenia is associated with widespread cortical thinning and abnormality in the structural covariance network, which may reflect connectome alterations due to treatment effect or disease progression. Notably, patients with treatment-resistant schizophrenia (TRS) have stronger and more widespread cortical thinning, but it remains unclear whether structural covariance is associated with treatment response in schizophrenia.
STUDY DESIGN: We organized a multicenter magnetic resonance imaging study to assess structural covariance in a large population of TRS and non-TRS, who had been resistant and responsive to non-clozapine antipsychotics, respectively. Whole-brain structural covariance for cortical thickness was assessed in 102 patients with TRS, 77 patients with non-TRS, and 79 healthy controls (HC). Network-based statistics were used to examine the difference in structural covariance networks among the 3 groups. Moreover, the relationship between altered individual differentiated structural covariance and clinico-demographics was also explored.
STUDY RESULTS: Patients with non-TRS exhibited greater structural covariance compared with HC, mainly in the fronto-temporal and fronto-occipital regions, while there were no significant differences in structural covariance between TRS and non-TRS or HC. Higher individual differentiated structural covariance was associated with lower general scores of the Positive and Negative Syndrome Scale in the non-TRS group, but not in the TRS group.
CONCLUSIONS: These findings suggest that reconfiguration of brain networks via coordinated cortical thinning is related to treatment response in schizophrenia. Further longitudinal studies are warranted to confirm if greater structural covariance could serve as a marker for treatment response in this disease.
INTRODUCTION: In academic breast surgery, ultrasound use tends to be limited to radiology departments, thus formal surgical resident training in breast ultrasound is sparse. Building on residents' ultrasound skills in our general surgery training program, we developed a novel curriculum to teach ultrasound-guided breast procedures (UGBPs), including core needle biopsy (CNB) and wire localization (WL). We hypothesized that learning UGBPs on cadavers would be preferred to learning with a breast phantom model using chicken breasts.
METHODS: Residents received a 1-h lecture on breast CNB and WL followed by a 1-h hands-on laboratory session. Olives stuffed with red pimentos were used to replicate breast masses and implanted in chicken breasts and the breasts of lightly embalmed and unembalmed female cadavers. All residents practiced UGBPs with a course instructor on both models. Residents completed anonymous prelaboratory and postlaboratory surveys utilizing five-point Likert scales.
RESULTS: A total of 35 trainees participated in the didactics; all completed the prelaboratory survey and 28 completed the postlaboratory survey. Participant clinical year ranged from 1 to 6. Residents' confidence in describing and performing CNBs and WLs increased significantly on postlaboratory surveys, controlling for clinical year (P < 0.001). Eighty-point seven percent preferred learning UGBPs on cadavers over phantoms most commonly citing that the cadaver was more realistic.
CONCLUSIONS: Following a novel 2-h UGBP training curriculum using phantom and cadaveric models, resident confidence in describing and performing UGBPs significantly improved. Most favored the cadaveric model and reported that the course prepared them for real-life procedures.
CYP2D6 Substrates

Abiraterone is an inhibitor of the hepatic drug-metabolizing enzymes CYP2D6. The co-administration of YONSA with CYP2D6 substrates increases the concentration of the CYP2D6 substrate, which may increase the frequency and/or severity of adverse reactions of these substrates. Avoid co-administration of abiraterone acetate with substrates of CYP2D6 with a narrow therapeutic index. If alternative treatments cannot be used, consider a dose reduction of the concomitant CYP2D6 substrate drug in accordance with its Prescribing Information [see Clinical Pharmacology (12.3)].

CYP2C8 Substrates

Abiraterone is an inhibitor of the hepatic drug-metabolizing enzymes CYP2D6 and CYP2C8. The co-administration of YONSA with CYP2C8 substrates increases the concentration of the CYP2C8 substrate, which may increase the frequency and/or severity of adverse reactions of these substrates. Therefore, patients should be monitored closely for signs of toxicity related to a CYP2C8 substrate with a narrow therapeutic index if used concomitantly with abiraterone acetate [see Clinical Pharmacology (12.3)].
Systemic sclerosis is a connective tissue disorder characterized by excessive fibrosis that primarily affects women, and can present as a multisystem pathology. Roughly 4-22% of patients with systemic sclerosis develop cancer, which drastically worsens prognosis. However, the mechanisms underlying systemic sclerosis initiation, propagation, and cancer development are poorly understood. We hypothesize that the inflammation and immune response associated with systemic sclerosis can trigger DNA damage, leading to elevated somatic mutagenesis, a hallmark of pre-cancerous tissues. To test our hypothesis, we culture clonal lineages of fibroblasts from the lung tissues of controls and systemic sclerosis patients and compare their mutation burdens and spectra. We find an overall increase in all major mutation types in systemic sclerosis samples compared to control lung samples, from small-scale events such as single base substitutions and insertions/deletions, to chromosome-level changes, including copy-number changes and structural variants. In the genomes of patients with systemic sclerosis, we find evidence of somatic hypermutation or kategis (typically only seen in cancer genomes), we identify mutation signatures closely resembling the error-prone translesion polymerase Polη activity, and observe an activation-induced deaminase-like mutation signature, which overlaps with genomic regions displaying kataegis.
Long-term animal studies have not been performed to evaluate the carcinogenic potential of the combination of clotrimazole and betamethasone dipropionate or either component individually.

Betamethasone was negative in the bacterial mutagenicity assay (Salmonella typhimurium and Escherichia coli) and in the mammalian cell mutagenicity assay (CHO/HGPRT). It was positive in the in vitro human lymphocyte chromosome aberration assay, and equivocal in the in vivo mouse bone marrow micronucleus assay.

In a combined study of the effects of clotrimazole on fertility, embryofetal development, and postnatal development, male and female rats were dosed orally (diet admixture) with dose levels of 5, 10, 25, or 50 mg/kg/day from 10 weeks prior to mating until 4 weeks postpartum. No adverse effects on the duration of estrous cycle, fertility, or duration of pregnancy were noted.

Reproductive studies with betamethasone dipropionate conducted in rabbits at doses of 1.0 mg/kg/day by the intramuscular route and in mice up to 33 mg/kg/day by the intramuscular route indicated no impairment of fertility except for dose-related increases in fetal resorption rates in both species.
In spite of their pivotal role in orchestrating immunity, dendritic cells (DCs) may be licensed by immunosuppressive signals to become tolerogenic. Here we show that ligation of cell surface glyco-receptors by Galectin-1, an endogenous glycan-binding protein, can drive the differentiation of regulatory DCs with tolerogenic potential in vivo. Galectin-1-differentiated DCs acquired a tolerogenic phenotype characterized by IL-27-dependent, STAT3-mediated and CD45RB + IL-10 +  regulatory signatures. Adoptive transfer of galectin-1-conditioned DCs induced T-cell tolerance in inflammatory and neoplastic settings and dampened T H 1- and T H -17-mediated autoimmune neuroinflammation. Consistent with a negative regulatory function of endogenous galectin-1, DCs from galectin- 1 -deficient (Lgals1 −/− ) mice had greater immunogenic capacity compared with their wild-type counterparts. Our findings identify a crucial role of galectin- 1  in the differentiation of IL-27-producing tolerogenic DCs with broad therapeutic implications in immunopathology. Thus, the present invention encompasses therapeutic formulations, comprising Galectin-induced tolerogenic DCs and a therapeutical acceptable carrier, methods of preparing said formulations and methods of using same.
Patients undergo standard of care CT simulation for radiation treatment planning using HyperArc software. 1 week later, patients undergo PULSAR fraction therapy once daily on days 0, 14, 28, 42, and 56. Patients may also undergo Positron Emission Tomography (PET) scan and MRI during follow-up.
Acute otitis media (AOM) is the most commonly cited indication for antibiotics in children, accounting for 24% of all pediatric antibiotic prescriptions and affecting 60% of children by 3 years of age. For most children ≥ 2 years of age with AOM, 5-7 days, rather than 10 days, of antibiotics have been shown to be sufficient and result in fewer adverse drug events with similar failure and recurrence rates. Thus, national guidelines recommend short durations of antibiotics for non-severe AOM in this age group. Despite these recommendations, \>94% of children ≥2 years of age are prescribed longer than recommended antibiotic durations and over 41% of antibiotic exposure days for AOM in this age group are likely unnecessary. In a recent pilot study that compared a low-cost High-intensity intervention with clinician education, individualized clinician audit and feedback with peer comparison and electronic health record (EHR) changes of prescription fields to a Low-intensity intervention with only EHR changes prescribing of recommended short antibiotic durations increased significantly (76% and 50%, absolute percentage). A definite study is needed to make appropriate recommendations on which intervention to implement, while minimizing resource utilization.

The overarching goal of this study is to evaluate the effectiveness and implementation outcomes of two low-cost pragmatic interventions of different intensities to increase prescribing of recommended short antibiotic durations for AOM for children 2 years of age and older. A multi-center cluster randomized controlled trial using a hybrid type 2 implementation effectiveness design will be used to evaluate interventions. The High-intensity intervention will include clinician education, individualized clinician audit and feedback with peer comparison, and EHR changes of prescription fields, whereas the Low-intensity intervention will include clinician education and EHR changes. In total, 46 community-based clinics and/or urgent care centers across two distinct geographic regions in the United States will be randomized to one of the two interventions. The Practical Robust Implementation and Sustainability Model will be used to guide implementation and the Reach Effectiveness Adoption Implementation Maintenance framework will be used to evaluate outcomes. A mixed-methods approach will be used in the pre-implementation and evaluation phases and will utilize quantitative analyses, semi-structured interviews, focus groups, surveys, and cost analyses.
In a study of 18 healthy subjects, 80 mg toremifene once daily coadministered with 200 mg of ketoconazole twice daily increased the toremifene Cmax and AUC by 1.4- and 2.9-fold, respectively. N-demethyltoremifene Cmax and AUC were reduced by 56% and 20%, respectively.

The administration of FARESTON with agents that are strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin, atazanavir, indinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, and voriconazole) increase the steady-state concentration in serum and should be avoided. Grapefruit juice may also increase plasma concentrations of toremifene and should be avoided. Should treatment with any of these agents be required, it is recommended that therapy with FARESTON be interrupted. If interruption of treatment with FARESTON is not possible, patients who require treatment with a drug that strongly inhibits CYP3A4 should be closely monitored for prolongation of the QT interval [see Boxed Warning and Warnings and Precautions (5.1)].
The invention is concerned with a medicine with tubeimosideIIor tubeimoside having tubeimoside II to anti-angiogenesis, anti tumor attack and transfer. ubeimosideIIis a chemical component distilled form fritillaria, and is the nature ramification of tubeimosideI. The tubeimoside having tubeimosideIIis tubeimosideIIand tubeimosideI, but not tubeimoside III. tubeimosideII has restraining effect for the increase of human vascular endothelial cells ECV-304 and accelerates to wither, the angiogenesis of chorioallantoic membrane and of the tumour cells on chorioallantoic membrane, the angiogenesis of tumour, the expression of tumour vascular endothelial growth factor and basic fibroblast growth factor, the test transfer of melanoma cells of small rat B 16 and spontaneity transfer of Lewis lung cancer cells. TubeimosideII abducts the drop of expression to transfer gene CD44v6 and ErBb-2 of Lewis lung cancer cells and the increase of expression to anti transfer gene nm23-H1. The tubeimosideIIor tubeimoside having tubeimoside II can be used to produce the medicine to anti angiogenesis, anti tumor attack and transfer.
The present invention describes the method for the degree of accuracy for improving infusion pump clogging sensor baseline. The invention provides an infusion pump, it comprises the logic for making anti-ratchet decision-making, for determining whether new doser has been installed after touching described doser. If so, set up new clogging sensor baseline. If not, keep current basic line. Described anti-ratchet decision logic can be depending on the value of baseline increment, and described baseline increment equals the difference between upstream sensor signal and downstream sensor signal. On the other hand, make upstream occlusion sensor needle position misalignment corresponding to reducing of occurring in upstream sensor signal described in the time that the pumping mechanism of described infusion pump does not operate, with compensation sensor signal drift.