anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Viral inflammation contributes to pathogenesis and mortality during respiratory virus infections. IRF3, a critical component of innate antiviral immune responses, interacts with pro-inflammatory transcription factor NF-κB, and inhibits its activity. This mechanism helps suppress inflammatory gene expression in virus-infected cells and mice. We evaluated the cells responsible for IRF3-mediated suppression of viral inflammation using newly engineered conditional Irf3Δ/Δ mice. Irf3Δ/Δ mice, upon respiratory virus infection, showed increased susceptibility and mortality. Irf3 deficiency caused enhanced inflammatory gene expression, lung inflammation, immunopathology, and damage, accompanied by increased infiltration of pro-inflammatory macrophages. Deletion of Irf3 in macrophages (Irf3MKO) displayed, similar to Irf3Δ/Δ mice, increased inflammatory responses, macrophage infiltration, lung damage, and lethality, indicating that IRF3 in these cells suppressed lung inflammation. RNA-seq analyses revealed enhanced NF-κB-dependent gene expression along with activation of inflammatory signaling pathways in infected Irf3MKO lungs. Targeted analyses revealed activated MAPK signaling in Irf3MKO lungs. Therefore, IRF3 inhibited inflammatory signaling pathways in macrophages to prevent viral inflammation and pathogenesis.
Diarrhoea is one of the major waterborne diseases spread through the faecal-oral route causing over 10 million cases and over 1,000 deaths per year in India. This study critically evaluates the interlinkage between bacteriological water quality, i.e. faecal coliforms and diarrhoea cases for the three pre-pandemic years 2017, 2018 and 2019 based on multiple sources. With around 17% of households tap water connectivity as of August 2019, the majority of the Indian population depends on raw groundwater (GW) and surface water sources. For this, faecal coliform (FC) levels in surface and GW have been mapped at district levels using data from India's National Water Quality Monitoring Programme. Health Management Information System's data on diarrhoea have been used to understand the monthly and district-wise variation of diarrhoea. The trends of FC, diarrhoea inpatient cases, and diarrhoea inpatient rates have been discussed. The analysis showed issues associated with the reliability and usefulness of these datasets with 43% of total India districts with no reported FC values for the study period. This study reveals a clear gap in the interlinkage between diarrhoea and bacteriological water quality with the unavailability of granular water quality data as a major challenge.
Study 1: Patients randomized to this arm will receive a standard phacoemulsification as soon as possible. About four weeks after phacoemulsification a vitrectomy is performed.
The invention relates to a medicine suitable for hemorrhagic early shock. The medicine has an obvious effect mainly aiming at hemorrhagic early shock. The medicine which conforms to the scientific law and has good taste is processed through compatibility of monarch, minister, assistant and guide of crude medicines according to the modern scientific research and reasonable screening. The medicine is prepared by grinding 3-6 parts of radix rehmanniae, 3-5 parts of herba ecliptae and 3-5 parts of herba agrimoniae into powder and mixing the powder. The aim of treating hemorrhagic early shock is to improve blood perfusion of the tissues all over the body and recover and maintain the normal metabolism and viscera organ functions of patients but not to simply increase the blood pressure. The medicine is simple and has an obvious effect.
Leuprolide acetate is a long-acting GnRH analog. A single injection of LUPRON DEPOT 11.25 mg results in an initial stimulation followed by a prolonged suppression of pituitary gonadotropins. Repeated dosing of LUPRON DEPOT 11.25 mg at quarterly intervals results in decreased secretion of gonadal steroids. Consequently, tissues and functions that depend on gonadal steroids for their maintenance become quiescent. This effect is reversible on discontinuation of drug therapy. 

Leuprolide acetate is not active when given orally.
PURPOSE:To obtain a health food effective in keeping or promoting the health and in preventing and remedying adult diseases and senile diseases by adding herbs and a functional food to edible vegetables and granulating the mixture. CONSTITUTION:An edible vegetable is compounded with herbs and functional foods and granulated to obtain the objective granule. The herb used in the above process is e.g. Epimedium sagittatum, bulb of lily, fruit of boxthorn, Houttuynia cordata, Panax ginseng, fig and licorice and the functional food is e.g. dietary fiber, linolein, chitin, carotene and calcium. The granule is a health food prepared by imparting drug action to conventional FURIKAKE (tasty seasoned dried food for sprinkling over rice). It is remarkably effective in keeping or promoting the health, improving the infirmity and preventing and remedying various diseases. Since the food has granular form, it has advantages of easy reconstitution and good dissolution.
According to a 2014 Cochrane Review, postpartum depression (PPD) is present in 13% of new mothers by twelve weeks postpartum. Infant feeding, sleep routines, growth, and socioemotional and cognitive development can be adversely affected by maternal PPD. These negative effects can last into childhood. Previous studies have shown that strong social support is protective against PPD. The 2014 Cochrane Review on this topic comments that simple, inexpensive interventions to decrease rates of PPD are needed and that interventions led by lay-people and done in groups may be helpful to decrease rates of PPD. More recent studies focus on interventions for mothers already showing symptoms of postpartum depression, not on preventing these symptoms from developing.

The proposed work is important, because it capitalizes on recommendations for future research from the 2014 Cochrane Review on Psychosocial and Psychological Interventions for Preventing Postpartum Depression. The proposed work is also innovative, because it involves a preventive intervention from lay-people in a group setting, with new moms benefiting from each other. At the completion of this project, it is our expectation that mothers in the intervention group will have sustained decreased rates of PPD.
PROBLEM TO BE SOLVED: To obtain the subject preparation by including aspirin and simultaneously a stabilizer selected from 2-20C organic esters, glycerol fatty acid esters, silicone oils, hydrocarbon oils and crotamiton. SOLUTION: This preparation simultaneously contains aspirin and one or more kinds of compounds selected from 2-20C organic acid esters, glycerol fatty acid esters, silicone oils, hydrocarbon oils and crotamiton as stabilizers. The 2-20C organic acid esters include the esters of myristic acid and isooctanoic acid. The glycerol fatty acid esters include sesame oil and middle chain fatty acid triglycerides. The hydrocarbon oils include liquid paraffin and squalane. The aspirin is added in an amount of 0.001-30 wt.% based on the total amount of the preparation, and the stabilizer is added in an amount of 0.1-20 times pts.wt. per pt.wt. of the aspirin. Thereby, the stability of the aspirin is maintained for a long period, and the preparation excellent in the transdermal absorption of the aspirin is obtained.
FIELD: medicine. ^ SUBSTANCE: invention relates to cosmetic industry, in particular, to composition for oral care, efficient for reduction of bad breath. Method to produce composition for oral care, with preliminary identification of substances efficient to reduce bad breath related to tobacco smoke. Method to eliminate bad breath related to tobacco smoke including introduction of composition for oral care, containing cardamom oil or cranberry extract. Agent efficient to reduce concentration of pyridine or pyrazine compound available in an individual oral cavity as a result of tobacco goods smoking, and elimination of bad breath at the same time, representing cardamom oil or cranberry extract. ^ EFFECT: composition efficiently reduces bad breath related to tobacco smoke. ^ 23 cl, 14 dwg, 15 tbl, 7 ex
POAG and OH patients prescribed latanoprost(QID) at least 3 months (IOP\>20). At least one eye must have a score above 1 on the NEI scale. Switch to latanoprost (QID) for 3 months.
The objective of the invention is to provide a photo-aging prophylactic agent for skin with novel ingredients and foods using the photo-aging prophylactic agent for skin, medicaments for mammals including human beings and a skin external agent, as well as feed for mammals. The inventive photo-aging prophylactic agent for skin is characterized by taking extracts of Orobanchaceae plants as effective ingredients. The photo-aging prophylactic agent for skin preferably comprises phenylethanoid glycosides compounds as effective ingredients. Moreover, the photo-aging prophylactic agent for skin preferably comprises at least one of echinacoside and acteoside as the phenylethanoid glycosides compounds. On top of that, the photo-aging prophylactic agent for skin preferably comprises both echinacoside and acteoside as the phenylethanoid glycosides compounds. In addition, the photo-aging prophylactic agent for skin can be employed as medicaments for mammals including human beings, skin external agents, consumptive foods and feed for mammals.
The invention provides a novel pharmaceutically acceptable salt of tenofovir alafenamide, and the 9-[(R)-2-[[(S)-[[(S)-1-(isopropionic carbonyl)ethyl]amino]phenoxylphosphinyl]methoxy]propyl]adenine semi-tartrate. The salt has modified chemical stability and thermal stability, and has a relatively high melting point. The salt is more suitable to be used as a raw materials medicine. Also, the salt has excellent crystallinity. The salt can be prepared with a convenient method, and purity and yield are further improved. The salt is suitable for large-scale industrialized productions.
BACKGROUND: Lung cancer is the leading cause of cancer-related death worldwide. We previously found that Mediator complex subunit 23 (MED23) is important for the tumourigenicity of lung cancer cells with hyperactive Ras activity in vitro, although the in vivo function of MED23 in lung tumourigenesis remains to be explored.
METHODS: In this study, we utilized well-characterized KrasG12D-driven non-small cell lung cancer mouse model to investigate the role of MED23 in lung cancer. The lung tumour progression was evaluated by H&E and IHC analysis. Western blotting and qRT-PCR assays were performed to detect changes in gene expression. Immune cells were analyzed by FACS technology. RNA-seq and reporter assays were conducted to explore the mechanism.
RESULTS: We observed that lung epithelial Med23 deletion by adeno-Cre resulted in a significant increase in KrasG12D tumour number and size, which was further verified with another mouse model with Med23 specifically deleted in alveolar type II cells. Mice with lung-specific Med23 deficiency also exhibited accelerated tumourigenesis, and a higher proliferation rate for tumour cells, along with increased ERK phosphorylation. Notably, the numbers of infiltrating CD4+ T cells and CD8+ T cells were significantly reduced in the lungs of Med23-deficient mice, while the numbers of myeloid-derived suppressor cells (MDSCs) and Treg cells were significantly increased, suggesting the enhanced immune escape capability of the Med23-deficient lung tumours. Transcriptomic analysis revealed that the downregulated genes in Med23-deficient lung tumour tissues were associated with the immune response. Specifically, Med23 deficiency may compromise the MHC-I complex formation, partially through down-regulating B2m expression.
CONCLUSIONS: Collectively, these findings revealed that MED23 may negatively regulate Kras-induced lung tumourigenesis in vivo, which would improve the precise classification of KRAS-mutant lung cancer patients and provide new insights for clinical interventions.
PURPOSE:A perfume composition, containing (2E,2E (or 4Z))-2,4,11-dodecatrienal and having green and fatty or ozonelike fragrance or orangy and ozonelike fragrance. CONSTITUTION:A perfume composition containing (2E,4E)-2,4,11-dodecatrienal expressed by formula I or (2E,4Z)-2,4,11-dodecatrienal expressed by formula II. The compound expressed by formula I has green and fatty tone and ozonelike fragrance, and the compound expressed by formula II has orangy and ozonelike fragrance. The above-mentioned compounds have very strong fragrances and are excellent as a perfume, but they are alone unstable. The stability is improved and excellent perfumes are exhibited by diluting and mixing the compounds with another perfume component. The above-mentioned composition is used by addition to a perfume, cosmetic, soap, shampoo, food, health, hygienic article, food, etc.
OBJECTIVES: Critical hyperbilirubinemia in preterm neonates, a condition requiring greater attention, is treated with phototherapy or exchange transfusion when bilirubin results exceed gestational age and age-specific medical decision levels (MDLs) to prevent bilirubin-induced neurologic damage. Conventional evaluation involves multiple manual steps and is poised to inconsistencies and delays.
METHODS: We designed and implemented an electronic clinical decision support (CDS) tool to identify and alert neonatal intensive care unit clinicians of critical hyperbilirubinemia with a SmartZone alert. We evaluated the performance of our manual evaluation workflow, the accuracy of the electronic CDS tool, and the outcome of the electronic CDS tool to reduce the time to place orders for interventions.
RESULTS: Among the 22 patients who met the criteria to have phototherapy ordered before implementing the electronic CDS tool, 20 (90%) had phototherapy ordered. Fourteen (70%) phototherapy orders were placed less than 24 hours, 4 phototherapy orders were placed 24 to 72 hours, and 2 orders were placed more than 72 hours after bilirubin results exceeded the corresponding MDLs. Among the 15 patients who met the criteria to have phototherapy ordered after implementing the electronic CDS tool, all (100%) received phototherapy orders, with 14 (93%) placed less than 24 hours and 1 order placed less than 48 hours. The electronic CDS tool identified all eligible patients correctly. The proportion of phototherapy ordered less than 24 hours increased from 70% to 93% after the implementation of the electronic CDS tool.
CONCLUSIONS: The electronic CDS tool promoted more appropriate and timely intervention orders to manage critical hyperbilirubinemia in preterm neonates.
In the extraction of the hormones secretin, cholecystokinin and pancreozymin from intestinal mucosa, the mucosa, suitably whilst attached to the structural tissue, is first heated for a time which does not substantially exceed the time required to coagulate the inert protein content and to inactivate the enzyme content.  Thus, hog duodenum is heated in boiling water for 5-10 minutes, and after storing in a frozen condition is extracted with 0.5N acetic acid. The extract at 0 DEG C. is filtered after the addition of diatomaceous earth, and the filtrate is contacted with cation exchanger containing carboxylic acid groups, e.g. alginic acid, oxycellulose or possibly "Amberlite" (Registered Trade Mark.  The adsorbed hormones are eluted with 0.2N hydrochloric acid and then precipitated with sodium chloride. The washed precipitate may be dissolved in water and reprecipitated.  Secretin may be separated from the other two hormones by extract with a lower, e.g. propyl, alcohol.
Methods of promoting neuroblast differentiation in subjects with neuroblastoma by administering an. agent to a subject with neuroblastoma are provided herein. The agent may be a heparin -sulfate proteoglycan co-receptor, heparin sulfate or a heparin analog. Promotion of neuroblast differentiation, may suppress neuroblast growth and treat neuroblastoma... Methods of determining a prognosis for a subject with neuroblastoma are also provided. The methods include measuring the level of at least one marker selected from FGF2, FGFR1, ID1, TβRIII, SDC3, SDC4, GPC3 and GPC1 in a sample from the subject and comparing the level in the subject to a reference level. If the levels of any of the markers are higher than the reference level the subject has a good prognosis. If the levels are lower than the reference level, the prognosis is poor.
Diagnosing and monitoring inflammatory bowel diseases, such as Crohn's disease, involves the use of endoscopic imaging, biopsies and serology. These infrequent tests cannot, however, identify sudden onsets and severe flare-ups to facilitate early intervention. Hence, about 70% of patients with Crohn's disease require surgical intestinal resections in their lifetime. Here we report wireless, miniaturized and implantable temperature sensors for the real-time chronic monitoring of disease progression, which we tested for nearly 4 months in a mouse model of Crohn's-disease-like ileitis. Local measurements of intestinal temperature via intraperitoneally implanted sensors held in place against abdominal muscular tissue via two sutures showed the development of ultradian rhythms at approximately 5 weeks before the visual emergence of inflammatory skip lesions. The ultradian rhythms showed correlations with variations in the concentrations of stress hormones and inflammatory cytokines in blood. Decreasing average temperatures over the span of approximately 23 weeks were accompanied by an increasing percentage of inflammatory species in ileal lesions. These miniaturized temperature sensors may aid the early treatment of inflammatory bowel diseases upon the detection of episodic flare-ups.
A process for the production of a "somatic antigen" vaccine comprises selecting bacteria, culturing the latter on a suitable nutrient medium, which includes an amino acid which is utilised in the formation of cell walls by said bacteria within the "critical concentration range", harvesting the resulting growth, inactivating and then lysing the bacteria.  The "critical concentration range" of the amino acid is generally between 0.1-5.0% w./v. of the nutrient medium.  It is defined as the range of concentration between the concentration above which the growth rate of a bacterium in a nutrient medium containing the amino acid starts to decrease and the concentration at which growth ceases. Specified amino acids are glycine, L-proline, DL-valine, L-histidine, DL-aspartic acid and L-arginine.  Lysis may be carried out using a proteolytic enzyme. The examples relate to the preparation of meningococcus, staphylococcus, mastitis, streptococcus, and blackleg vaccines.
They will receive HVHDF treatment for 48 hours. HVHDF will be performed via indwelling central venous catheter. The blood flow will be 180-240 ml/min, and ultrafiltration rate will be 70 ml/kg/h during HVHF. The substitute fluid will be infused with pre-dilution. Heparin will be used for anti-coagulation, whose initial dose will be 15-25 U/kg, and maintenance dose is 5-15 U/kg/h. aPTT time maintained between 60-80 second and will be checked every 12 hours. The survival status of all of the subjects were followed up at 28 days after being diagnosed as severe sepsis.
In a 104-week oral carcinogenicity study in rats, mycophenolate sodium was not tumorigenic at daily doses up to 9 mg per kg, the highest dose tested. This dose resulted in approximately 0.6 to 1.2 times the systemic exposure (based on plasma AUC) observed in renal transplant patients at the recommended dose of 1,440 mg per day. Similar results were observed in a parallel study in rats performed with MMF. In a 104-week oral carcinogenicity study in mice, MMF was not tumorigenic at a daily dose level as high as 180 mg per kg (which corresponds to 0.6 times the recommended mycophenolate sodium therapeutic dose, based on body surface area). 

The genotoxic potential of mycophenolate sodium was determined in five assays. Mycophenolate sodium was genotoxic in the mouse lymphoma/thymidine kinase assay, the micronucleus test in V79 Chinese hamster cells, and the in vivo mouse micronucleus assay. Mycophenolate sodium was not genotoxic in the bacterial mutation assay (Salmonella typhimurium TA 1535, 97a, 98, 100, and 102) or the chromosomal aberration assay in human lymphocytes. 

Mycophenolate mofetil generated similar genotoxic activity. The genotoxic activity of mycophenolic acid (MPA) is probably due to the depletion of the nucleotide pool required for DNA synthesis as a result of the pharmacodynamic mode of action of MPA (inhibition of nucleotide synthesis). 

Mycophenolate sodium had no effect on male rat fertility at daily oral doses as high as 18 mg per kg and exhibited no testicular or spermatogenic effects at daily oral doses of 20 mg per kg for 13 weeks (approximately 2 times the systemic exposure of MPA at the recommended therapeutic dose). No effects on female fertility were seen up to a daily dose of 20 mg per kg (approximately 3 times the systemic exposure of MPA at the recommended therapeutic dose).
The patients included in the treatment group will follow a prehabilitation program, based on a physiotherapist, nutritionist and psychologist evaluation. All the treatments will be tailored according the characteristics of each single patient. The program will have a duration of, at least, 4 weeks.
In the routine care arm, assessment visits will be scheduled according to the timing of maintenance treatment injections up to Week 48, which will be in compliance with the EU SmPC for ustekinumab for the treatment of Crohn's disease, in which dosing every 12 weeks is recommended. At Week 16, (that is, 8 weeks after the first SC dose) participants continuing in the study will have demonstrated a CDAI-70 response. Nonetheless, participants who have not shown adequate response based on the investigator's judgment may receive a second SC dose at Week 16. During the routine care maintenance treatment period, in case of clinical worsening reported by the participant, consistent with disease flare in the investigator's judgment, clinical assessments of disease flare will be performed at the investigator's discretion.
Serotiny is an adaptive trait that allows certain woody plants to persist in stand-replacing fire regimes. However, the mechanisms by which serotinous cones avoid seed necrosis and nonserotinous species persist in landscapes with short fire cycles and serotinous competitors remain poorly understood. To investigate whether ovulate cone traits that enhance seed survival differ between serotinous and nonserotinous species, we examined cone traits in 24 species within Pinaceae and Cupressaceae based on physical measurements and cone heating simulations using a computational fluid dynamics model. Fire-relevant cone traits were largely similar between cone types; those that differed (e.g. density and moisture) conferred little seed survival advantage under simulated fire. The most important traits influencing seed survival were cone size and seed depth within the cone, which was found to be an allometric function of cone mass for both cone types. Thus, nonserotinous cones should not suffer significantly greater seed necrosis than serotinous cones of equal size. Closed nonserotinous cones containing mature seeds may achieve substantial regeneration after fire if they are sufficiently large relative to fire duration and temperature. To our knowledge, this is the most comprehensive study of the effects of fire-relevant cone traits on conifer regeneration supported by physics-based fire simulation.