anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention discloses a preparation method of traditional Chinese medicine wine for supporting yang and tonifying spleen. According to the method, 90 g of each of radix astragali, cortex cinnamomi, morinda officinalis, dendrobium, oriental waterplantain rhizome, poria cocos, platycladi seeds, dry ginger, and pericarpium zanthoxyli, 60 g of each of radices sileris, radix angelicae pubescentis, and gen-seng, 30 g of each of (processed) aconitum carmichaeli debx., Chinese herbaceous peony, (processed) monkshood, (processed) aconite, skimmia, processed pinellia ternate, as arum, bighead atractylodes rhizome, scutellaria, trichosanthes kirilowii roots, and cornus officinalis, and 4500 ml of liquor are prepared. The preparation method comprises: preparing the first 23 traditional Chinese medicines into crude powder, adding the powder into a cloth bag, putting the cloth bag into a container, adding liquor, sealing the container, and soaking for 3-7 days for use. The wine has the efficacy of tonifying qi, supporting yang, tonifying spleen, draining dampness, warming meridian and freeing collateral vessels. The wine is mainly used for treating extreme internal deficiency-cold which belongs to spleen wind. The wine can treat typhoid fever due to yin moving, body weight loss, inability of raising limbs, arthralgia, anorexia, and symptoms caused by extreme deficiency. The wine is for oral administration. Thirty milliliters of the wine can be taken at first, and then the dosage can be increased till slight impediment; and the wine is taken twice a day.
We planned a prospective, randomomized, double blind study of 2 pain management protocols in consecutive patients undergoing thoracotomy for MIDCAB or lung tumor resection over a 6 month period. After patients emerged from a standardized general anesthetic and when objectively awake and complaining of pain \>5/10 on a visual analogue pain scale, they were connected to an intravenous patient controlled analgesia regimen. The regimen was assigned randomly to be either morphine alone (1.5 mg per dose, lockout interval of 7 minutes) or morphine plus ketamine (1.0 mg morphine plus 5 mg ketamine per dose, same lockout interval). Rescue diclofenac was available to both groups. Follow-up lasted 4 hours.

We planned to monitor and compare pain scores, wakefulness scores, hemodynamic and respiratory parameters as well as total morphine consumption and incidence of side effects and complications. All monitoring and recording was done by blinded nurses and intensive care physicians.
Subjects will have a etonogestrel contraceptive implant placed at enrollment. Women using COC as method of contraception for at least 1 month will be considered COC users. Women starting a COC or recently started a COC within the past month will be considered new starts.
A mist generation device which easily generates mist containing an agent of desired concentration. The mist generation device (1) has a flow path (3) through which liquid flows. A first branch path (12) branched from the flow path is provided with a pump (13) for sucking the liquid from the flow path. A second branch path (14) is branched from that portion of the first branch path which is located downstream of the pump, and the second branch path (14) is provided with a containing section (15) for containing the agent. A mixing section (8) forms solution by mixing the liquid having passed through the flow path and the liquid having passed through the first and second branch paths. A mist generation section (30) sprays the solution created by the mixing section (8).
INTRODUCTION: Traumatic hemorrhage is a leading cause of preventable mortality worldwide. The Stop the Bleed (STB) course was developed to equip layperson bystanders with basic bleeding control knowledge and skills. However, large in-person courses have been disrupted due to COVID-19. The aim of this study was to determine the feasibility of teaching and evaluating STB skills through remote video-based instruction.
METHODS: After undergoing COVID-19 screening, groups of up to eight STB-naive adults were seated in a socially distanced manner and given individual practice kits. A remote STB-certified instructor provided the standard STB lecture and led a 10-min skills practice session via videoconferencing. Participants' skills were evaluated on a 10-point rubric by one in-person evaluator and three remote evaluators. Participants completed a postcourse survey assessing their perceptions of the course.
RESULTS: Thirty-five participants completed the course, all scoring ≥8/10 after examination by the in-person evaluator. Remote instructors' average scores (9.8 ± 0.45) did not significantly differ from scores of the in-person evaluator (9.9 ± 0.37) (P = 0.252). Thirty-three participants (94%) completed the postcourse survey. All respondents reported being willing and prepared to intervene in scenarios of life-threatening hemorrhage, and 97% reported confidence in using all STB skills.
CONCLUSIONS: STB skills can be effectively taught and evaluated through a live video-based course. All participants scored highly when evaluated both in-person and remotely, and nearly all reported confidence in skills and knowledge following the course. Remote instruction is a valuable strategy to disseminate STB training to students without access to in-person courses, especially during pandemic restrictions.
The trial seeks to compare the benefits of adding a diagnostic test that can distinguish the etiology of an acute respiratory illness early in the work-up and management. All adult patients shall be evaluated through the Emergency Department (ED) as an undiagnosed acute reparatory illness (URI). The included patient cohort must present with SIRS criteria and be ill enough to require immediate blood draw and management by the ED. Excluded are any URIs with a predetermined diagnosis or subjects presenting with illness not determined to be a URI as a primary diagnosis. The experimental arm of the study shall have in addition to the standard of care labs and diagnostics, a novel protein array blood test that can distinguish bacterial from viral disease. The control group will not receive these results. The trial seeks to examine the difference in clinical outcomes when a adjunct biomarker than can help the clinician guide more accurate therapy is available early in the diagnostic workup. Benefits are defined in the primary and secondary outcomes as reduced resources expended through reduced laboratory, radiological, blood bank, and pharmaceutical expenditures. Comparative resource utilization costs include changes in hospital and or ED length of stay, lower follow up visits and readmissions, less inpatient and outpatient physician consultants and services called for to manage the patients care, and overall costs. Both primary and secondary outcomes will be used to categorize the costs and resources required to manage the patient. Primary objective is to evaluate overall changes in patient management and longer-term resource utilization between control and test arms, including (but not limited to) additional work-up (including other diagnostic tests and consults), antimicrobial treatments, disposition decisions and hospital length of stay (LOS). The exploratory objective is to evaluate changes between control and test arm in ED LOS, bounce backs (patients returning within 72 hours), work-up costs and the impact of physician seniority.
The invention belongs to the technical field of biomedical high polymer materials, and discloses a polymer/lithium algae soil nanoparticle composite thermotropic hydrogel with adjustable phase transition, a preparation method and application thereof. The hydrogel consists of lithium alginate soil nano particles, amphiphilic block copolymer and solvent. The gel is in a flowing sol state at low temperature or room temperature, and can spontaneously form a thermotropic hydrogel at body temperature along with the rise of temperature. Wherein the amphiphilic block copolymer is a block copolymer formed by taking polyethylene glycol (PEG) as a hydrophilic block and taking degradable polyamino acid as a hydrophobic block. According to the invention, hydrogen bond interaction can be generated between the lithium algae soil and the block copolymer, and the phase transition temperature of a compound system can be effectively regulated and controlled by regulating and controlling the compound proportion and concentration of the lithium algae soil nano particles and the block polymer. The hydrogel has good biocompatibility and biodegradability, and can meet the application requirements of drug delivery and tissue engineering repair.
Hygiene promoters will deliver hygiene promotion through an activity that provoke the feeling of comfort by having clean hands. Hygiene promoters will deliver this intervention to up to 5 neighbor households at the time, sharing a story about a family that keeps good hygiene behaviors and therefore are clean, healthy and happy. This story is believed to encourage families to increase handwashing with soap in the household.
This will be a randomized controlled trial. Participants will be assigned to Eye Movement Desensitization and Reprocessing (EMDR) Therapy or Treatment as Usual (TAU) through block randomization. This process will be done using the program available at www. randomization.com.

In this study, EMDR Therapy will be applied in adolescents with BD and compared to the Usual Treatment. The neuropsychological profile of the patients will be evaluated before and after the interventions. In addition, the collection of the biological markers related to BD will be done by measuring the levels of salivary cortisol and serum levels of C-reactive protein (CRP), Brain Derived Neurotrophic Factor (BDNF), Interleukin (IL) - 1β, IL - 2, IL - 4, IL - 6, IL - 10, Interferon gamma (IFN-γ) and Tumor Necrosis Factor alpha(TNF-α) in these patients, since a study proposing the use of serological biomarkers for BD diagnosis concluded that the use of a single biomarker would be of little use and a combination of several biomarkers would be necessary.
Renal function should be closely monitored during the co-administration of Rapamune with cyclosporine, because long-term administration of the combination has been associated with deterioration of renal function. Patients treated with cyclosporine and Rapamune were noted to have higher serum creatinine levels and lower glomerular filtration rates compared with patients treated with cyclosporine and placebo or azathioprine controls (Studies 1 and 2). The rate of decline in renal function in these studies was greater in patients receiving Rapamune and cyclosporine compared with control therapies.

Appropriate adjustment of the immunosuppressive regimen, including discontinuation of Rapamune and/or cyclosporine, should be considered in patients with elevated or increasing serum creatinine levels. In patients at low- to moderate-immunologic risk, continuation of combination therapy with cyclosporine beyond 4 months following transplantation should only be considered when the benefits outweigh the risks of this combination for the individual patients. Caution should be exercised when using agents (e.g., aminoglycosides and amphotericin B) that are known to have a deleterious effect on renal function.

In patients with delayed graft function, Rapamune may delay recovery of renal function.
Participants will receive DHES0815A in escalating doses in the dose-escalation cohort of the study. Participants will receive additional infusions of DHES0815A on Day 1 of subsequent cycles provided that they meet the protocol specified criteria for acceptable toxicity and ongoing clinical benefit.
Patients with Crohn disease commonly have bowel strictures develop, which exhibit varying degrees of inflammation and fibrosis. Differentiation of the distinct inflammatory and fibrotic components of strictures is key for the optimization of therapeutic management and for the development of antifibrotic drugs. Cross-sectional imaging techniques, including ultrasound, CT, and MRI, allow evaluation of the full thickness of the bowel wall as well as extramural complications and associated mesenteric abnormalities. Although promising data have been reported for a range of novel imaging biomarkers for detection of fibrosis and quantification of the degree of fibrosis, these biomarkers lack sufficient validation and standardization for clinical use. Additional methods, including PET with emerging radiotracers, artificial intelligence, and radiomics, are also under investigation for stricture characterization. In this review, we highlight the clinical relevance of identifying fibrosis in Crohn disease, review the histopathologic aspects of strictures in Crohn disease, summarize the morphologic imaging findings of strictures, and explore contemporary developments in the use of cross-sectional imaging techniques for detecting and characterizing intestinal strictures, with attention given to emerging quantitative biomarkers.
High affinity, chemically modified triplex-forming oligonucleotides (TFOs) and methods for use thereof are disclosed. TFOs are defined as triplex-forming oligonucleotides which bind as third strands to duplex DNA in a sequence specific manner. Triplex-forming oligonucleotides may be comprised of any possible combination of nucleotides and modified nucleotides. Modified nucleotides may contain chemical modifications of the heterocyclic base, sugar moiety or phosphate moiety. A high affinity oligonucleotide (K d ≦2×10 −8 ) which forms a triple strand with a specific DNA segment of a target gene DNA is generated. It is preferable that the K d  for the high affinity oligonucleotide is below 2×10 −10 . The nucleotide binds or hybridizes to a target sequence within a target gene or target region of a chromosome, forming a triplex region. The binding of the oligonucleotide to the target region stimulates mutations within or adjacent to the target region using cellular DNA synthesis, recombination, and repair mechanisms. The mutation generated activates, inactivates, or alters the activity and function of the target gene.
Arformoterol tartrate inhalation solution is supplied in a single strength (15 mcg of arformoterol, equivalent to 22 mcg of arformoterol tartrate) as 2 mL of a sterile clear, colorless solution in low-density polyethylene (LDPE) unit-dose ampule overwrapped in foil. Arformoterol tartrate inhalation solution is available in a shelf-carton containing 30 or 60 unit-dose ampules.

NDC 0093-5955-56: carton of 30 individually pouched unit-dose ampules.

NDC 0093-5955-06: carton of 60 unit-dose ampules (12 x 5 unit‐dose ampule pouches).

Storage and Handling

Store arformoterol tartrate inhalation solution in the protective foil pouch under refrigeration at 36° to 46°F (2° to 8°C). Protect from light and excessive heat. After opening the pouch, unused unit-dose ampules should be returned to, and stored in, the pouch. An opened unit-dose ampule should be used right away. Discard any unit-dose ampule if the solution is not colorless. Unopened foil pouches of arformoterol tartrate inhalation solution can also be stored at room temperature 68° to 77°F (20° to 25°C) for up to 6 weeks. If stored at room temperature, discard if not used after 6 weeks or if past the expiration date, whichever is sooner.
Systemic diseases affecting the immune system can influence the body's response time to endodontic treatment, potentially necessitating a longer duration for the complete resolution of existing infections when compared to healthy controls. This systematic review aims to evaluate the association between the presence of chronic diseases and periapical status after endodontic treatment through a systematic and comprehensive assessment of existing literature on this topic. The search strategy covered seven electronic databases and grey literature, encompassing articles published until October 2023. Two reviewers independently assessed potentially eligible studies based on the following criteria: Included were studies involving populations exposed to pre-existing chronic diseases who underwent endodontic treatment in permanent teeth. These studies evaluated periapical health status, making comparisons with healthy individuals. There were no language or publication date restrictions. Additionally, two reviewers independently extracted data regarding the characteristics of the included studies. The risk of bias was assessed using the Joanna Briggs Institute Critical Assessment Checklist. Meta-analysis was conducted using random effects models. The certainty of evidence was assessed using the GRADE tool. Twenty-three studies were included in the synthesis. Patients with diabetes were found to have about half the odds of having periapical health compared to non-diabetic patients (OR = 0.46; 95% CI = 0.30-0.70%; I2 = 58%) in teeth that underwent endodontic treatment. On the other hand, other systemic diseases like HIV, cardiovascular disease, and rheumatoid arthritis did not demonstrate significant differences concerning the outcome. In conclusion, diabetic patients showed a lower likelihood of maintaining periapical health. Conversely, patients with HIV, cardiovascular disease, and rheumatoid arthritis did not exhibit significant differences, although the existing evidence is still considered limited. It is crucial to manage these patients in a multidisciplinary manner to provide appropriate care for this population.
The study assesses the feasibility of an implantable myoelectric prosthesis control system to control a transradial prosthesis. Implantable Myoelectric Sensors (IMES) will be implanted into the residual forearm muscles of three transradial amputee subjects. These devices wirelessly transmit electrical muscle signals to an electromechanical prosthetic wrist and hand.

Following a two-week recovery from implantation of up to 16 IMES into residual forearm muscles, subjects will begin a two week training phase. When they receive their custom-fit IMES Transradial Prosthesis (including electromechanical wrist and hand) subjects initiate approximately four months of home use. Subjects will be offered up to five post-study follow-up visits. The usability and functionality of the prosthetic system will be evaluated throughout the study.
The present invention relates to a tablet prepared by using a codonopsis pilosula effective ingredient extract product-codonopsis pilosula polysaccharide. A codonopsis pilosula effective ingredient codonopsis pilosula polysaccharide tablet is mainly prepared from the following raw materials of (by weight portion) 100 to 600 portions of codonopsis pilosula effective ingredient codonopsis pilosula polysaccharide, 2 to 4 portions of low-substituted hydroxypropyl cellulose or microcrystalline cellulose and 0.5 to 1.5 portions of magnesium stearate, wherein the low-substituted hydroxypropyl cellulose or the microcrystalline cellulose and the magnesium stearate are supplementary materials. The supplementary materials of cocoa power or mannitol are added, and chewable tablets or buccal tablets can be made. In the present invention, the codonopsis pilosula polysaccharide is used as a main raw material for preparing the codonopsis pilosula polysaccharide tablet, a small amount of low-substituted hydroxypropyl cellulose or microcrystalline cellulose, magnesium stearate, etc. which are supplementary materials can be selected and matched to make the tablet. Conventional taking number at a time is from 1 to 4 tablets, and the present invention can achieve the requirements for containing of 1 to 1.5 grams of codonopsis pilosula polysaccharide in a therapeutic dose. The codonopsis pilosula polysaccharide tablet has the advantages of small volume, stable quality, high purity, accuracy dose, small tablet weight variation, homogeneous external appearance color, smoothness, cleanness, beauty, outstanding curative effect, convenient taking, convenient recognition, storage and transportation, etc.
Migraine is a serious health problem that disrupts quality of life and ranks second among primary headaches, affecting over 10% of the general population. In Turkey, the lifetime prevalence of migraine is reported to be 16%, with rates of 10.9% in men and 21.8% in women. Migraine is characterized by episodic attacks that may include headaches accompanied by vomiting, nausea, phonophobia, or photophobia. Chronic migraine is defined as a headache occurring on 15 or more days per month for over three months, with migraine features present on at least 8 of those days. The International Classification of Headache Disorders criteria for migraine require only two of four commonly seen pain features; thus, a non-throbbing, bilateral headache can still meet migraine criteria if it is moderate to severe, worsens with physical activity, and is accompanied by migraine-specific symptoms. Neck pain related to stress, which is sometimes associated with tension-type headache, is also a common feature of migraine.

Measurements play a crucial role in scientific research across various fields, including natural sciences, social sciences, and health sciences. In the biomedical sciences, many clinical conditions, psychological behaviors, attitudes, and beliefs are challenging to measure accurately. These may include disease severity, disease-related quality of life, pain perception, anxiety, and more. To quantify and assess specific attributes, researchers develop tools known as "scales" that consist of various components. Clinical scales are tools used in medicine to evaluate different aspects of a patient's health, including physical and mental health symptoms, functional abilities, and overall quality of life.

The Headache Needs Assessment (HANA) is designed to assess two dimensions of the chronic impact of migraine-related quality of life issues: frequency and discomfort. It comprises seven items and serves as a useful screening tool for evaluating the impact of migraine on individuals. Its two-dimensional approach to patient-reported quality of life enables individuals to weigh the influence of both the frequency and discomfort of chronic migraines on various aspects of daily life. This scale will fill a gap in the Turkish literature regarding the parameters it evaluates and will serve as a valuable tool in the field.
PURPOSE:To provide a bathing agent containing zeolite adsorbed with effective hot-spring gas components such as carbon dioxide gas, hydrogen sulfide, etc., and effective to attain the bathing effect of the above component pleasantly in home without increasing the salt content in a bath. CONSTITUTION:An effective gaseous component of hot-spring, e.g. carbon dioxide gas, hydrogen sulfide, radon, etc., especially carbon dioxide gas or hydrogen sulfide is adsorbed to a zeolite, preferably a synthetic zeolite having improved gas-absorptivity, especially an aluminosilicate of formula (M is Na, K, Ca or Mg; n is atomic valence of M; x is 0.7-1.5; y is 0.8-1.0), and the zeolite is used as a component of a bathing agent. The hot-spring curing effect can be achieved by the above gaseous component by the addition of the above bathing agent to bath water, and the agent can be added repeatedly to the bath water in the reheating of the bath without causing the increase in the salt concentration. The agent gives excellent feeling to the body. When the gaseous component is carbon dioxide gas, the pH of an aqueous solution containing 0.01wt% bathing agent is preferably 4-7.