anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology that predominantly affects children, and no specific diagnostic biomarkers for KD are available. Platelet-derived growth factor CC (PDGF-CC) is a peptide with angiogenic properties that has been amply demonstrated to play a critical role in the cardiovascular system. This study aimed to investigate the serum expression of PDGF-CC in children with KD and to evaluate the ability of PDGF-CC to diagnose KD.
METHODS: A total of 96 subjects, including 59 KD patients, 17 febrile controls (FC), and 20 healthy controls (HC), were enrolled. Serum levels of PDGF-CC were measured via enzyme-linked immunosorbent assay. The associations between PDGF-CC and clinical laboratory parameters were investigated by correlation analysis. The diagnostic performance was assessed by receiver operating characteristic (ROC) curve analysis.
RESULTS: Serum PDGF-CC levels in the KD group were significantly higher than in the FC and HC groups. Serum PDGF-CC levels in the KD group were positively correlated with white blood cell counts, percentage of neutrophils, IL-2, IL-12p70, TNF-α, and IL-1β levels, and negatively correlated with the percentage of lymphocytes. In the analysis of ROC curves, the area under the curve was 0.796 (95% confidence interval 0.688-0.880; P < 0.0001) for PDGF-CC and increased to 0.900 (95% confidence interval 0.808-0.957; P < 0.0001) in combination with white blood cell counts and C-reactive protein.
CONCLUSIONS: PDGF-CC is a potential biomarker for KD diagnosis, and the combination with white blood cell counts and C-reactive protein can further improve diagnostic performance.
Only Phenylketonuria (PKU) patients will be studied. Controls are generated from the literature. Reference CIMT values exist for a healthy population based on age and gender (Engelen et al., 2013), eliminating the need to assess age- and gender-matched controls. The study would otherwise require performing blood tests and vascular assessments on healthy individuals, generating a risk of harm and a possible incidental finding. It would be inconvenient for controls because they would need to travel to hospital and undergo invasive venepuncture.
Patients receive trametinib PO QD on days 1-21. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
The invention discloses a natural deworm sterilization fragrant bag and comprises an outer bag and components therein. According to the weight share, the components comprise 10-60 shares of root of dahuriae angelica, 8-30 shares of borneol, 10-30 shares of clove, 5- 20 shares of kaempferia galamga, 2-10 shares of interior eardamom, 2-10 shares of cinnamon, 2-10 shares of dried old orange peel, 2-10 shares of eupatorium, 2-10 shares of wild chrysanthemum, 2-10 shares of angelica sinensis, 5-20 shares of lysimachia foemum, 5-30 shares of bamboo carbon, 10-30 shares of natural plant dried flowers. Each component of Chinese herbs in the bag can be synthetically used with the natural plant dried flowers. The components of Chinese herbs and the dried flowers can affect and cooperate with each other and have the function of repelling mosquito and sterilization. Meanwhile the natural plant dried flowers can cover the medicinal odor and enable natural fragrant of the fragrant bag to be refreshed and can also take fragrant to the person who brings the fragrant bag. The invention has good effect of restoring consciousness, strengthening heart capacity and refreshment, and brings people with joy.
The invention discloses a method and a device for generating questions and answers of a traditional Chinese medicine teaching material based on a generation type model. And then, acquiring prompts according to the Chinese medicine subject word list by using a prompt learning method, constructing a model training sample with the subject data, and training to obtain a subject generation model. And then calculating the richness of the medical text in each paragraph of the original text, and selecting the paragraphs with higher richness as the sources of the generated problems. And selecting paragraphs to perform word segmentation and filtering to calculate word criticality, and selecting keywords as answer texts. And inputting the selected paragraphs and the answer text into a model to obtain a generated question, and forming a question-answering question with the answer. The invention provides a method suitable for calculating the text information richness of paragraphs in the professional field, which is beneficial to selecting high-quality paragraphs so as to improve the quality of generated problems.
###  Carcinogenesis

No mutagenic or clastogenic effects were detected in conventional genotoxicity studies with pretomanid. A circulating metabolite of pretomanid, M50, was mutagenic in a bacterial reverse mutation assay. No carcinogenic potential was revealed in a 6-month study in transgenic mice where this metabolite was produced. In a 2-year study in rats, there was no evidence of carcinogenic risk.

###  Mutagenesis

No mutagenic or clastogenic effects were detected in both an in vitro bacterial reverse mutation assay and an in vitro mammalian chromosome aberrations assay using a Chinese hamster ovary cell line. Pretomanid was negative for clastogenicity in a mouse bone marrow micronucleus assay.

A metabolite of pretomanid was mutagenic in a bacterial reverse mutation assay. This metabolite represents approximately 6% of the human exposure (AUC) to pretomanid at the MRHD. 

###  Fertility

In a fertility and general reproduction study in rats, male rats treated orally with pretomanid for 13 to 14 weeks had reduced fertility at 30 mg/kg/day and complete infertility at 100 mg/kg/day (approximately 1 and 2‑times the human exposure for a 200 mg dose, respectively). At 100 mg/kg/day, males had testicular atrophy including hypospermia in the epididymal tubules and focal epithelial hyperplasia of the epididymal tubular epithelium. Following a 10-week treatment-free period, these effects were partially reversed in male rats given pretomanid at 30 mg/kg/day but not at 100 mg/kg/day. These effects were associated with increased serum follicle-stimulating hormone and decreased serum inhibin B concentrations. There were no effects of pretomanid in male rats treated for 13 weeks at 10 mg/kg/day (approximately half of the human exposure for a 200 mg dose). Pretomanid did not affect mating behavior in female rats given oral pretomanid at 100 mg/kg/day for two weeks (approximately twice the human exposure).

Testicular toxicity was present in male mice treated orally for 13 weeks at 20 mg/kg/day [approximately equal to the human exposure (AUC) for a 200 mg dose]. There were no adverse testicular effects observed in mice given pretomanid at 6 mg/kg/day (0.2‑times the human exposure for a 200 mg dose).

Testicular toxicity was observed in male rats following 7 or 14 days of dosing with oral pretomanid at 100 mg/kg/day (approximately 2-times the human exposure for a 200 mg dose). The effects were partially reversible during a 6-month post treatment recovery period in rats treated with pretomanid for 7 days, but not 14 days.

In a 3-month study, decreased sperm motility and total sperm count, and increased abnormal sperm ratio were noted in sexually mature monkeys given ≥150 mg/kg/day (approximately 3 times the human exposure for a 200 mg dose).
Compounds which have one of structural formulae (I) or (II). AA is an amino acid residue or an amino acid chain of two or more amino acid residues, excluding the N-terminal and the C-terminal from said amino acid residue or amino acid chain of two or more amino acid residues; R1 is hydrogen or an alkyl group having from 1 to 8 carbon atoms; R2 is selected from the group consisting of (i) a substituted or unsubstituted hydrocarbon having from 1 to 20 carbon atoms, and (ii) (a). R4 is an aliphatic hydrocarbon having 1 to 4 carbon atoms. R4 may be substituted or unsubstituted. R3 is selected from the group consisting of (i) hydrogen; (ii) (b), wherein R5 is hydrogen or a nitro group; and (iii) (c), wherein each of R6, R7, and R8 is hydrogen or methyl. The above compounds are useful as pharmaceuticals for inhibiting the growth of target cells, viruses, or virally-infected cells.
The present invention relates to 'Buxueyimu Particles' which are compound Chinese medicinal preparations for nourishing both qi and blood and removing blood stasis for promoting tissue regeneration. A making method of the present invention comprises the following steps: preparing Donkey-hide Gelatin powder, preparing a paste made from angelica and dried tangerine peel and preparing a paste made from milkvetch root and motherwort herb. After the two kinds of pastes are mixed to form the fine powder of the dry paste by spraydrying, the donkey-hide gelatin powder is mixed, and then the granulating step, the drying step, the checking step and the subpackaging step are carried out. The Buxueyimu Particles produced according to the present invention has refined recipe and outstanding curative effects and has the functions of vigorating qi, replenishing the blood and removing blood stasis for promoting tissue regeneration. The Buxueyimu Particles are new Chinese medicines for treating the deficiency of qi and the blood, blood stasis, etc. After operations and parturition, has low manufacturing cost and is worthy of being widely popularized and applied.
BACKGROUND: Sleep loss is a common public health problem that causes hyperalgesia, especially that after surgery, which reduces the quality of life seriously.
METHODS: The 48-h sleep restriction (SR) mouse model was created using restriction chambers. In vivo imaging, transmission electron microscopy (TEM), immunofluorescence staining and Western blot were performed to detect the status of the blood-spinal cord barrier (BSCB). Paw withdrawal mechanical threshold (PWMT) was measured to track mouse pain behavior. The role of infiltrating regulatory T cells (Tregs) and endothelial cells (ECs) in mouse glycolysis and BSCB damage were analyzed using flow cytometry, Western blot, CCK-8 assay, colorimetric method and lactate administration.
RESULTS: The 48-h SR made mice in sleep disruption status and caused an acute damage to the BSCB, resulting in hyperalgesia and neuroinflammation in the spinal cord. In SR mice, the levels of glycolysis and glycolysis enzymes of ECs in the BSCB were found significantly decreased [CON group vs. SR group: CD31+Glut1+ cells: p < 0.001], which could cause dysfunction of ECs and this was confirmed in vitro. Increased numbers of infiltrating T cells [p < 0.0001] and Treg population [p < 0.05] were detected in the mouse spinal cord after 48-h SR. In the co-cultured system of ECs and Tregs in vitro, the competition of Tregs for glucose resulted in the glycolysis disorder of ECs [Glut1: p < 0.01, ENO1: p < 0.05, LDHα: p < 0.05; complete tubular structures formed: p < 0.0001; CCK8 assay: p < 0.001 on 24h, p < 0.0001 on 48h; glycolysis level: p < 0.0001]. An administration of sodium lactate partially rescued the function of ECs and relieved SR-induced hyperalgesia. Furthermore, the mTOR signaling pathway was excessively activated in ECs after SR in vivo and those under the inhibition of glycolysis or co-cultured with Tregs in vitro.
CONCLUSIONS: Affected by glycolysis disorders of ECs due to glucose competition with infiltrating Tregs through regulating the mTOR signaling pathway, hyperalgesia induced by 48-h SR is attributed to neuroinflammation and damages to the barriers, which can be relieved by lactate supplementation.
The present invention relates to a new, simple method for separating and preparing natural polyphenolic antioxidants from natural sources. The method comprises steam blanching of the starting material (e.g. olive leaves), drying, extraction with an edible organic solvent (e.g. ethanol) and separation of the phenolic compounds from the final extract by Cloud Point Extraction using food grade surfactants (e.g. lecithin). The present invention provides a low-cost physical product, totally free from toxic residues. The phenolic compounds, entrapped in the micelles of the surfactant, as well as the phenolic antioxidant powder produced in a drum dryer or spray dryer, may be used as a dietary supplement, as additive and natural preservative in cosmetics, bakery products, meat products, dairy products, canned food, for the reconstitution and stabilization of refined oils and as a source of natural phenolic antioxidant compounds.
OBJECTIVE: The purpose of this study is to compare radiological and clinical outcomes between alternate levels (C4 and C6) and all levels mini-plate fixation in C3-6 unilateral open-door laminoplasty.
METHODS: Ninety-six patients who underwent C3-6 unilateral open-door laminoplasty with alternate levels mini-plate fixation (54 patients in group A) or all levels mini-plate fixation (42 patients in group B) between September 2014 and September 2019 were reviewed in this study. Radiologic and clinical outcomes were assessed. Clinical results included Visual Analogue Scale (VAS) of axial neck pain and Japanese Orthopedic Association (JOA) score. Radiographic results included cervical range of motion (ROM), cervical curvature index (CCI), and the spinal canal expansive parameters including open angle, anteroposterior diameter (APD), and Pavlov`s ratio.
RESULTS: There was no significant difference in VAS, JOA score, ROM, and CCI between two groups. There was no significant difference in canal expansion postoperatively between two groups. However, open angle, APD, and Pavlov`s ratio in group A decreased significantly during the follow-up. In group B, APD, Pavlov`s ratio, and open angle were maintained until the final follow-up. There was no hardware failure or lamina reclosure occurred in both groups during the follow-up. The mean cost of group B was higher than that of group A.
CONCLUSIONS: Despite the differences in the maintenance of canal expansion, alternate levels mini-plate fixation can achieve similar clinical outcomes as all levels mini-plate fixation in C3-6 unilateral open-door laminoplasty. As evidenced in this study, we believe C3-6 laminoplasty with alternate levels (C4 and C6) mini-plate fixation is an economical, effective, and safe treatment method.
Airway mucous cell metaplasia is a significant feature of many chronic airway diseases, such as chronic obstructive pulmonary disease, cystic fibrosis and asthma. However, the mechanisms underlying this process remain poorly understood. Here, we employed in vivo mouse genetic models to demonstrate that Hippo and p53 (encoded by Trp53) cooperate to modulate the differentiation of club cells into goblet cells. We revealed that ablation of Mst1 (Stk4) and Mst2 (Stk3), encoding the core components of Hippo signaling, significantly reduces mucous metaplasia in the lung airways in a lipopolysaccharide (LPS)-induced lung inflammation murine model while promoting club cell proliferation in a Yap (Yap1)-dependent manner. Additionally, we showed that deleting Mst1/2 is sufficient to suppress p53 deficiency-mediated goblet cell metaplasia. Finally, single-cell RNA-sequencing analysis revealed downregulation of YAP and p53 signaling in goblet cells in human airways. These findings underscore the important role of Hippo and p53 signaling in regulating airway mucous metaplasia.
The invention relates to application of ganoderic acid A in preparing a medicament for treating CRPC. According to the invention, the research shows that the GAA can obviously inhibit proliferation, PSA secretion, clone formation, wound healing, migration and invasion of LNCaP-AI cells, and can obviously inhibit growth of castration resistant prostate cancer cells in vivo; abnormal activation of AKT, GSK-3 beta and the like in LNCaP-AI cells can be effectively inhibited by GAA; top-flash luciferase assay determined that activated β -catenin could also be inhibited. From this, it was clarified that AKT/GSK-3. Beta. -catenin pathway is involved in the action process of GAA on CRPC. The invention defines the therapeutic activity of ganoderic acid A on CRPC, and particularly researches the action mechanism of ganoderic acid A, provides a new active substance for delaying the process of converting prostate cancer ADT into CRPC and treating castration resistant prostate cancer, and provides a new therapeutic target and direction for the development of the subsequent castration resistant prostate cancer drugs.
The multiple myoma study group will have Foley-catheter intrauterine balloon dilatation therapy 2 weeks and 4 weeks after hysteroscopic myomectomy. A second-look hysteroscopy will be carried out 6 weeks after the surgery.
Fish transport workers in Indonesia lift loads more than the specified limits, both in weight and frequency. This could cause lactic acid accumulation, fatigue and reduced physical performance. The aim of this study was to assess the effect of stretching intervention on muscle tension, fatigue, strength, and lactic acid level in fish transport workers in Indonesia. A pre-experimental study design with one group (pre- and post-test) design was conducted among male fish transport workers at the Tawang fish auction, Weleri, Central Java, Indonesia, in June 2022 for two weeks. We created a 1.5-minute stretching exercise video based on the University of New Castle's Manual Handling guideline, involving hand, feet, and shoulder movements. Participants performed these exercises independently before and during work every two hours, guided by the video. Data on lactic acid, muscle tension, fatigue, and strength were collected before and after the 2-week intervention. Data analysis was performed using Wilcoxon and paired Student t-tests to compare the outcome between post- and pre-intervention. A total of 18 fish transport workers were included in the study. The results showed a statistically significant increase in lactic acid levels following the intervention (p=0.016). However, the increase in muscle tension was not statistically significant (p=0.292). There was a significant increase in fatigue levels after the intervention (p=0.000). This could suggest that the stretching intervention may have had an unintended effect of increasing fatigue among the participants. On the other hand, there was a statistically significant decrease in muscle strength after the intervention (p=0.003). In conclusion, this study suggests that while stretching exercises can affect lactic acid accumulation, fatigue, and muscle strength, they do not influence muscle tension. Therefore, it is advised for workers to incorporate stretching exercises into their daily routine to mitigate potential injury risks.
There are a limited number of studies in the literature examining the effects of therapeutic play implemented by nursing students. Although there are many studies showing that therapeutic play intervention is an effective intervention for sick children, it is seen that these studies are mostly conducted by researchers or clinical staff, and nursing students who have been in pediatric wards for a long time due to their clinical practices are far from therapeutic play practices. Therapeutic play may be a way for nursing students to initiate communication with children more easily. Therefore, there is a need for large-scale studies including nursing students. Starting from their student years, nursing students using therapeutic play as a means of communication with sick children may make them more willing to use such activities in their professional lives. In addition, determining the satisfaction levels is important for the continuation of such studies in clinical practice.
Plaster inhalant for the application of essential oils and the like to the chest without any soiling by greasy constituents. The active substances are effective via the percutaneous or inhalational route. For this purpose, the active substances are applied to a solid carrier which is welded or bonded between two plastic films. For passage of the evaporating active substances the plastic film is perforated on the side lying upon the skin and on the outer side. The solid carrier may be, for example, absorbent paper or another absorbent material. The inhalant system prepared in this way is welded into plastic-laminated aluminium foils in order to avoid any evaporation losses of the active substance during storage. The system can be stuck to the chest or hung around the neck. The shape of the foil may differ to suit the particular body.
Adalimumab levels and antibodies will be obtained with every laboratory examination (every 2 months, except for the first 2 visits). Dose or interval adjustment will be performed as followed:when trough levels results taken prior to ADA injection are above 5 µg/ml no change in dosing is required. Detectable levels below 5 µg/ml will result in interval decrease to every week. If levels are still below 5 µg/ml dose will be increased to 40 mg (in patients receiving less than 40 mg). Undetectable levels below 0.3µg/ml will be followed by antibodies (ATAs) measurement. If ATAs are persistently above 8 µg/ml the patient will discontinue the study. If ATAs are below 8 µg/ml ADA intervals will be decreased to every week.
The vegetable material is solvent extracted followed by concn. of the extract and addn. of a part of the shampoo ingredients. After clarification of the soln., the flavanoid content is determined and the extract is diluted as required with a soln. contg. another part of the shampoo ingredients. The extract results in shampoos which are stable to storage, contain a standardised amt. of flavanoids and give an excellent blonding effect.
PURPOSE:A cosmetic, prepared by combining beeswax with a mineral, e.g. germanium, and having improved make-up effect particularly as a basic cosmetic. CONSTITUTION:A cosmetic prepared by incorporating a cosmetic containing beeswax as a basic component with a mineral, e.g. germanium, or a cosmetic containing the beeswax containing the mineral e.g. germanium, as a component. The resultant cosmetic contains a mineral having the enzymic activating effect for the skin by the co-enzymic action related to the enzymic activity and another skin effect in an active form, has improved stability with time and is completely nontoxic and capable of exhibiting improved make-up effect particularly as a basic cosmetic. In addition to the germanium, the following are effective as the mineral: Calcium, phosphorus, potassium, sulfur, sodium, magnesium, iron, manganese, iodine, zinc, silicon, aluminum, chromium, mokybdenum, selenium, etc.
Using a consecutive inclusion, we aim to include 60 children and register data proposed by the COS for PEVA. All items of the PBS-score are video-documented, and dynamic foot pressure during walking is recorded during a clinical visit at the Motion Analysis Lab at Karolinska University Hospital. Children and caregivers will complete Roye's score, a disease-specific PROM and Oxford Foot and Ankle Questionaire-child (OxFAQc). For children aged 6 years or older, standing radiographic imaging of both feet will be performed. Inclusion criteria include: age 4-8 years, a diagnosis of idiopathic clubfoot, ability to walk 10 m repeatedly, and ability to communicate verbally (and in writing for caregivers) in Swedish or English. Included children will be followed prospectively during five years through clinical visits and medical records, where need for additional treatment (casting, braces and/or surgery) is the primary endpoint.