anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
It is thought that Congenital muscular torticollis (CMT) affects the muscles as well as the development of the head and face, causing various asymmetries, delays in gross motor functions, and disorders in posture and balance control. Bent neck position can cause plagiocephaly. Characteristic craniofacial deformities are asymmetry in the eyebrows and cheekbones, deviation of the chin and nose tip, inferior orbital abnormality on the affected side, asymmetry in ear placement, and shortening of the vertical dimension of the ipsilateral face. It has been shown that in later periods, it may cause asymmetry in the use of the upper extremities in children, delay in gross motor functions, and effects on posture and balance control. Head position; It is thought that it may cause a negative impact on posture control and movement development, sensorimotor coordination, and retardation in gross motor function by affecting the shoulder, rib cage and abdominal muscles. Motor skills and sensory experiences begin to develop after birth and development continues as children grow. Having good motor control also helps children explore the world around them, which can help many other areas of development. There are many environmental and biological factors that affect motor development. Especially the home environment, where the child spends most of his time, is one of the key factors affecting motor development. The home environment is known to be a very important factor for motor development in babies. At the same time, the variety of equipment and environmental conditions help children provide different sensory experiences. Since it is a common practice for physiotherapists to advise patients on home activities, exploring the home environment can have important effects on development. For these reasons, it was thought that the motor development and sensory processing suggestions given in the home environment for children diagnosed with torticollis would be supported by home environment opportunities. This study was planned to examine the relationship between the opportunities offered in the home environment and motor development and sensory processing in children diagnosed with congenital muscular torticollis.
PURPOSE:To correctly measure the shape of a measured article (e.g. tooth, artificial tooth. implant structure body, and chin bone) which is exposed in a buccal cavity and contains a small quantity of hydrogen atoms or dose not contain hydrogen atom by using an MRI image device. CONSTITUTION:A measurement cover 10 is installed on a measured article 8, and the inside of the cover is filled with the MRI contrast media 9 for the MRI buccal measurement such as the jelly which contains a large quantity of hydrogen atoms. Then, the periphery of the measured article 8 is covered in an airtight form by the MRI contrast media 9 for the buccal cavity measurement. In this state, the measurement for the measured article 8 is carried out by using an MRI image device. Then, the MRI contrast media 9 for the buccal cavity measurement can correctly be selected by the MRI image device, and consequently, the shape of the measured article 8 can correctly be measured from the shape of the MRI contrast meadium 9 for the baccal cavity measurement which contacts the measured article 8 in effect.
This group of patients will receive manual therapy techniques to harmonize vegetative nervous system. PPG and GSR will be recorded during the intervention. The techniques consist of CV-4 technique, suboccipital decompression, lumbo-sacral decompression, release of the transverse diaphragms, frontal lift technique, parietal lift technique, temporal techniques, temporo-mandibular joint myofascial release, deep cervical fasciae technique as described in Upledger's protocol. In addition to the protocol; rib raising technique, larynx and sternocleidomastoid muscle fascial release and occipito-mastoid suture release will be applied. All intervention is planned to take approximately 20 minutes. The group will include 40 healthy individuals.
There are no controlled studies assessing the effectiveness of pharmacological interventions to decrease aggression in perpetrators of domestic violence. Since serotonin reuptake inhibitors (SSRI) have been shown to decrease aggression in other patient populations, we will examine the effectiveness of SSRIs in reducing aggression in perpetrators of domestic violence. In this protocol, perpetrators of domestic violence will be randomized according to a double-blind design to receive either the SSRI, fluoxetine, or placebo. All participants will receive psychotherapy. All participants will also be carefully monitored in the outpatient clinic on a regular basis for three months. Drug efficacy will be established using validated rating scales and provocative aggression inducing paradigms.
CHD patients, both males and females, aged \> 18 years will be included in the study, should they provide written informed consent and have a sufficient initial physical and intellectual capacities allowing an independent daily living. Moreover, they must have documented CHD (prior myocardial infarction, prior coronary angiography or angioplasty, or documented myocardial ischemia on myocardial scintigraphy).
This group received the same oral care that experimental group with the use of a similarly formulated gel without the antiseptic agent.The gel is applied on a toothbrush, and the teeth are cleaned in quadrants; all teeth surfaces are cleaned (vestibular, lingual, occlusal, and incisal). After each quadrant is cleaned, 10 mL of water (dispensed via a syringe) is used to rinse the quadrant and continual aspiration is used to remove all the gel and debris. After all the teeth are cleaned, the ventral surface of the tongue is brushed with posterior to anterior movements.
PURPOSE: To obtain a wound coating material having excellent stability of quality, controllablity of a sol-gel transition temp. and efficiency of gelatinization by specifying the average degree of polymn. of the water-soluble polymer chains between the adjacent side chains in the graft copolymer of this wound coating material, the ratio of the side chains and the mol.wt. of this graft copolymer. CONSTITUTION: This wound coating material is formed of the graft copolymer in which the water-soluble polymer main chain is bonded with a polymer an aq. solution of which has a cloud point as the side chain and the water. The average degree of polymn. of the water-soluble polymer main chains between the adjacent side chains in the graft copolymer is specified to >=10, the ratio of the side chains to 10 to 90wt.% and the mol.wt. of the graft copolymer to >=100,000. The wound coating material is otherwise formed of the graft copolymer in which the water-soluble polymer main chain is bonded with the polymer an aq. solution of which has the cloud point as the side chain and the water and the mol.wt. of the graft copolymer is specified to >=100,000.  The wound coating material prepd. in such a manner does not contain unknown impurities and uniformity of the compsn. and the stability of the performance are easily assured. The material is free from worry about toxicity.
The objective of this clinical project is to determine the status of choline and related metabolites in a large group of children with Cystic Fibrosis (CF). Based on the results it will be possible to determine which children are deficient or at risk for choline deficiency, and might benefit most from supplementation to sustain improvement in the plasma choline, and its metabolites. This will be a cross-sectional study that will, over a 6 month period, look to enroll as many patients as possible from 140 children with CF who are seen regularly at the CF Clinic at B.C.'s Children's Hospital. The study will involve the collection of blood and urine at the time of a scheduled appointment. All procedures for enrollment, collection of chart data and blood samples will follow procedures used in our previous studies. Body weight and height will be measured and routine blood work including liver enzymes, hematology, serum zinc, selenium and vitamins A and E will be completed as part of the clinic appointment. CF genotype, gender, birth date, hematology, clinical chemistry, anthropometric and nutritional measures, liver ultrasound, biopsy reports where available, pancreatic function (elastase, chymotrypsin/secretin-CCK) and all medications including mineral, vitamin and nutritional and enzyme supplements will be recorded from chart data. Blood samples will be used for analyses of choline and its metabolites and various biomarkers in redox pathways. A urine sample will be collected and used to assay excretion of related metabolites. Creatine will be analyzed to avoid the need for quantitative 24 hour urine collection.
Rotator cuff (RC) rupture causes shoulder pain, muscle weakness, and decreased shoulder range of motion (ROM). Additionally, fear of movement develops due to shoulder pain, affecting ROM and function. Treatment of RC rupture is initially conservative. In cases where conservative treatment is inadequate, surgical option is preferred. Open, mini-open and arthroscopic repair can be used in surgery. In recent years, arthroscopic repair has been mostly preferred because it causes less pain than other surgical options, has a shorter hospital stay, and does not cause complications. A postoperative rehabilitation program is a crucial component of surgical success. The aim of this program is to reduce pain, increase ROM, and improve patients' functional level and activities of daily living. The postoperative rehabilitation program includes electrophysical agents, manual therapy and exercise.Surgery-related inflammation may restrict fascial tissue. Inflammation changes the mechanical properties of connective tissue, causing adhesions and eventually leading to stiffness. Thus, the slip between fascial surfaces decreases and, accordingly, ROM and function decrease.

Instrument Assisted Soft Tissue Mobilization (IASTM) is used for myofascial restriction and fascial release. IASTM is used to reduce pain in the area where the pathology is located, increase range of motion (ROM), improve movement function and provide a mobilizing effect. However, it is noteworthy that there is a lack of studies examining the long-term effectiveness of fascial mobilization in shoulder pathologies. When the literature was examined, no study was found examining the effectiveness of the IASTM technique, which is known to require less effort and stimulate healing compared to manual interventions, in the rehabilitation period after rotator cuff arthroscopic surgery. Therefore, our study aimed to examine the effects of instrument-assisted fascial mobilization given in addition to conventional rehabilitation on long-term pain, function, range of motion, fear of movement, and daily living activities in patients 4 weeks after rotator cuff arthroscopic surgery.
<P>PROBLEM TO BE SOLVED: To provide information, which is helpful to understand the relationship between the state of coronary arteries and cardiac activity, to physicians who perform diagnoses of cardiac functions.  <P>SOLUTION: A cardiac cavity region is extracted from a three dimensional functional image that represents evaluation index data of cardiac functions, and a cardiac function bull's eye image that represents the functions of the cardiac cavity is generated (13). Coronary artery image data are extracted from three dimensional anatomical images that represents the structures of the heart and the coronary artery, and coronary artery closed curved surfaces that include the extracted coronary artery image data are calculated (15). A coronary artery bull's eye image is generated from the extracted coronary artery image data (16), and distances from the boundary surface of the cardiac cavity region to the coronary artery closed curved surfaces are calculated, based on the coronary artery closed curved surfaces (17). Display output is controlled such that the cardiac function bull's eye image, the coronary artery bull's eye image, and information representing the calculated distances are displayed simultaneously on the screen of a display device.  <P>COPYRIGHT: (C)2011,JPO&INPIT
A temporary alteration of lipoproteins in the form of decreased high density lipoproteins and possibly increased low density lipoproteins has been reported during danazol therapy. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient.

Before initiating therapy of fibrocystic breast disease with danazol, carcinoma of the breast should be excluded. However, nodularity, pain, tenderness due to fibrocystic breast disease may prevent recognition of underlying carcinoma before treatment is begun. Therefore, if any nodule persists or enlarges during treatment, carcinoma should be considered and ruled out.

Patients should be watched closely for signs of androgenic effects some of which may not be reversible even when drug administration is stopped.
PURPOSE:To obtain the subject composition capable of simultaneously, and stably incorporating the identical composition with active ingredients differing in function from one another, and capable of combining an active ingredients having been difficult to combine and also presenting the synergistic effect of their functions. CONSTITUTION:This liquid three-layered composition is made up of the upper layer consisting of a liquid oily component such as liquid paraffin, silicone oil, vegetable fatty oil, animal fatty oil or fatty acid ester, the intermediate layer consisting of a liquid nonionic surfactant >=500 (pref. 600-1500) in the organic value calculated from the organic conceptual projection and 0-700 (pref. 50-500) in the difference between the organic value and the inorganic value, and the lower layer consisting of a hydrotropic liquid (e.g. a polyhydric alcohol, aliphatic lower monohydric alcohol). The composition, when shaken, is readily brought to a homogeneously dispersed state which can be maintained for a desired constant time depending on the choice of the surfactant. This surfactant is e.g. a polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether.
The present invention relates to a slightly acidic environment-sensitive and ketal-linked gefitinib axially substituted boron subphthalocyanine complex and a preparation method therefor and a medical use thereof. In particular, the present invention relates to a boron subphthalocyanine-gefitinib complex as shown in general formula (I) and a preparation method therefor and a pharmaceutical composition containing the complex, and the use thereof as a photosensitiser, especially the use in the treatment of cancers, wherein the definition of each substituent in general formula (I) is the same as that in the description. In a normal tissue environment, due to the interplay between the boron subphthalocyanine group and the gefitinib group, the complex has a lower cytotoxicity. However, in the extracellular slightly-acidic environment of tumour tissue, ketals hydrolyse and the fragments of the hydrolysate, i.e. boron subphthalocyanine, exhibit an extremely high photosensitive activity, while a gefitinib derivative obtained by hydrolysis can be used as an inhibitor of epidermal growth factor receptor (EGFR) tyrosinase for inhibiting tumour growth. The complexes can be prepared into photodynamic therapeutic and chemotherapeutic double-efficacy anticancer drugs targeting both the tumour extracellular slightly-acidic environment and the EGFR tyrosine kinase.
Participants who test positive for Helicobacter pylori by fecal antigen testing will be offered treatment with triple therapy (clarithromycin 500 mg per os twice daily, amoxicillin 1 g per os twice daily, omeprazole 40 mg per os twice daily) for 14 consecutive days. Two to four weeks following the completion of treatment, participants will repeat fecal antigen testing to confirm whether they eradicated the Helicobacter pylori.
Amphibians globally suffer from emerging infectious diseases like chytridiomycosis caused by the continuously spreading chytrid fungi. One is Batrachochytrium salamandrivorans (Bsal) and its disease ‒ the 'salamander plague' ‒ which is lethal to several caudate taxa. Recently introduced into Western Europe, long distance dispersal of Bsal, likely through human mediation, has been reported. Herein we study if Alpine salamanders (Salamandra atra and S. lanzai) are yet affected by the salamander plague in the wild. Members of the genus Salamandra are highly susceptible to Bsal leading to the lethal disease. Moreover, ecological modelling has shown that the Alps and Dinarides, where Alpine salamanders occur, are generally suitable for Bsal. We analysed skin swabs of 818 individuals of Alpine salamanders and syntopic amphibians at 40 sites between 2017 to 2022. Further, we compiled those with published data from 319 individuals from 13 sites concluding that Bsal infections were not detected. Our results suggest that the salamander plague so far is absent from the geographic ranges of Alpine salamanders. That means that there is still a chance to timely implement surveillance strategies. Among others, we recommend prevention measures, citizen science approaches, and ex situ conservation breeding of endemic salamandrid lineages.
FIELD: hygiene.SUBSTANCE: group of inventions relates to an oral care composition and use thereof. Disclosed oral care composition comprises the following components (A) and (B): (A) N-acylglutamic acid or a salt thereof in an amount of 0.005% by weight to 0.3% by weight; and (B) pyrophosphoric acid or salt thereof in an amount of 0.005% by weight to 0.5% by weight. Acyl group of component (A) is represented by one or more groups selected from a group consisting of a lauroyl group, a myristoyl group and a cocoyl group. Weight ratio ((B)/(A)) of component (B) to component (A) ranges from 0.05 to 40. Total content of component (A) and component (B) ranges from 0.01% by weight to 0.6% by weight. Also disclosed is the use said composition for cleaning teeth with a brush or for rinsing the mouth. Use of the composition allows for the complete removal of a protein deposit on the tooth surface, can effectively prevent the build-up of a protein deposit on the tooth surface and can give a good actual sensation of the cleansing result in the oral cavity.EFFECT: presence of a certain amount of said N-acylglutamic acid in the composition provides excellent acid resistance and good stability of the disclosed composition when stored at low ambient temperatures.14 cl, 3 dwg, 9 tbl, 29 ex
Clonal monocytosis reflects a preneoplastic or neoplastic sustained increase in the absolute monocyte count in the absence of reactive causes. Causes of clonal monocytosis include clonal cytopenias with monocytosis and acute and chronic myeloid neoplasms. Chronic myelomonocytic leukemia is a prototypical myelodysplastic/myeloproliferative overlap neoplasm in adults, characterized by sustained peripheral blood monocytosis. Kidney abnormalities, including acute kidney injury and chronic kidney disease, are frequent in patients with chronic myelomonocytic leukemia and are predictors of worse outcomes. In addition, acute kidney injury/chronic kidney disease often limits eligibility for allogeneic stem cell transplantation or enrollment in clinical trials. In this review, we highlight clonal monocytosis-related etiologies that give rise to acute kidney injury and chronic kidney disease, with special emphasis on chronic myelomonocytic leukemia and lysozyme-induced nephropathy. Monocytes produce lysozyme, which, in excess, can accumulate in and damage the proximal renal tubular epithelium. Early identification of this etiology and a timely reduction in monocyte counts can salvage kidney function. Other etiologies of kidney injury associated with clonal monocytosis include direct renal infiltration by monocytes, renal extramedullary hematopoiesis, myeloproliferative neoplasm-associated glomerulopathy, autoimmune (membranous nephropathy, minimal change disease) and paraneoplastic manifestations, thrombotic microangiopathy, obstructive nephropathy due to myeloproliferation, and urate nephropathy due to tumor lysis syndrome. We propose to group these mechanistic etiologies of kidney injury as clonal monocytosis of renal significance and provide guidance on their diagnosis and management.
Patients aged 1-6 years old will be enrolled. Routine SPECT imaging will be performed 3-4 h post-administration (PA) with a dual-detector rotating gamma camera over a 360˚ rotation for 8 s per view using a 1282 matrix. In each age group, half of the subjects will also be imaged between 30 and 90 min, post-administration. The 2nd half will be imaged at 4-6 h, post-administration. It is important to note that the patient volunteers will not receive any additional radiation exposure for inclusion in this study. They are only being ask to allow imaging at one additional time point.
The standard of care to treat congestive heart failure is with a class of medication called diuretics, which remove the extra fluid from the body through urination. Another way to remove extra fluid in patients with heart failure is called ultrafiltration. Ultrafiltration may result in more rapid removal of excess fluid and more rapid improvement in your symptoms compared to standard diuretic treatment. Currently, it is unknown what effects these therapies (diuretics or ultrafiltration) have on the small blood vessels in your heart. These small blood vessels are important to supply blood and oxygen to your failing heart. Thus, the purpose of this research study is to compare the effects (good and bad) of ultrafiltration treatment with standard intravenous (in your vein) diuretic therapy on your heart function and blood flow.
This is a single arm study. All subjects who are eligible for treatment will begin taking vigabatrin (Sabril) during the third month of the study. Treatment will be in accordance with the FDA-approved prescribing information: upward titration will happen at a rate of 500mg per week until subjects reach their maximum tolerated dose, or 3g per day (whichever is lower). This dose may be decreased if needed under the supervision of the study doctor. Subjects who need to lower their dose or who stop taking Sabril will have their dosage decreased at a rate of 1 gm/week for one month under the supervision of the study doctor.
Ointment base is based on a brushable hydrocarbon mixture contg. water/oil and oil/water emulsifiers, opt. together with other adjuvants. The ointment base contains 7-20 wt. % of one or more water/oil emulsifiers and 7-25 wt. % of one or more oil/water emulsifiers. By addition of water, the ointment base can be converted into an amphiphilic cream. The ointment base permits fine and homogeneous distribution and optimal release of active ingredients. Its rheological properties are good, and physical and chemical stability are favourable. The finished preparations can readily be washed off, and undesired physiological effects (e.g. allergenicity) are absent. The formulations are well tolerated, and they are miscible with other dermatological preparations.
* Both the outer pouch and the inner blister packaging containing the individual implants are designed to be peeled open. Aseptically peel open the outer pouch, then remove and aseptically peel open the three inner blister packages containing XARACOLL. To avoid cutting the implants prior to placement, do not open the blister packaging using scissors or a scalpel.
  * Carefully remove XARACOLL from the inner blister packages and inspect each implant prior to use.
  * Using aseptic technique, cut each XARACOLL implant in half prior to placement into the surgical site. Place three halves below the site of mesh placement and three halves just below the skin closure.
  * XARACOLL may become difficult to move once placed in the surgical site and moistened. Use care when moving XARACOLL after placement.