anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The demographic shift, together with financial constraint, justify a re-evaluation of the trajectory of care of very old critically ill patients (VIP), defined as older than 80 years. We must avoid over- as well as under-utilisation of critical care interventions in this patient group and ensure the inclusion of health care professionals, the patient and their caregivers in the decision process. This new integrative approach mobilises expertise at each step of the process beginning prior to intensive care unit (ICU) admission and extending to long-term follow-up. In this review, several international experts have contributed to provide recommendations that can be universally applied. Our aim is to define a minimum core dataset of information to be shared and discussed prior to ICU admission and to facilitate the shared-decision-making process with the patient and their caregivers, throughout the patient journey. Documentation of uncertainty may contribute to a tailored level of care and ultimately to discussions around possible limitations of life sustaining treatments. The goal of ICU care is not only to avoid death, but more importantly to maintain an acceptable quality of life and functional autonomy after hospital discharge. Societal consideration is important to highlight, together with alternatives to ICU admission. We discuss challenges for the future and potential areas of research. In summary, this review provides a state-of-the-art current overview and aims to outline future directions to address the challenges in the treatment of VIP.
BACKGROUND: The aim of this study is to analyze the process and frontiers of research in myocardial bridges (MB) to identify future research directions in the last 3 decades.
METHODS: Relevant literature on MB combined with myocardial infarction (MI) was searched from 1991 to 2023 in the Web of Science database, and was analyzed by bibliometric analysis using VOSviewer, CiteSpace, and the R package "bibliometrix."
RESULTS: A total of 1233 English articles were included in this study. The number of published articles showed an increasing trend yearly. From 2017 to 2022, the annual publication volume rose rapidly, and in 2021 the publication volume even reached 95 articles, which was the highest in all years. These publications were from 68 countries and 1854 institutions, with the leading country being the U.S. and the leading institution being Columbia University. Myoho Clinical International has a close collaborative relationship with Columbia University, while in recent years, the Harvard Medical School has explored the study of MB combined with MI. Annals of Thoracic Surgery was the journal with the highest number of publications, and Takayama Hiroo and Naka Yoshifumi were the authors with the highest number of publications. The most common keywords were MI, cardiogenic shock, and MB.
CONCLUSIONS: Our findings can help researchers explore the current status of MB combined with MI research and choose new survey routes for upcoming studies. Prevalence and prognosis, mechanism of MB combined with MI and molecular mechanism may become the focus of future research. In addition, more research and cooperation are needed worldwide.
OBJECTIVES: This study aimed to evaluate the aetiology, management and outcomes of convulsive status epilepticus (CSE) in children and highlight the factors influencing patient outcomes in such cases.
METHODS: In a retrospective study spanning the 2020-2023 period, 93 children with CSE treated at Sultan Qaboos University Hospital's emergency department (ED), high dependency unit (HDU) and intensive care unit (ICU) were analysed. The Modified Rankin Scale at discharge was used to determine CSE outcomes.
RESULTS: Among the 93 children studied (mean age 4.84 ± 3.64 years), predominantly Omani (92.47%), 14 aetiologies were noted. Of them, acute symptomatic (37.7%) and febrile status (31.2%) were the primary causes of CSE. Diazepam was administered as the first-line treatment in 58 (67.44%) cases, with a median seizure duration of 45 minutes. Successful seizure control was achieved in 71 (76.34%) cases within 60 minutes. A return to baseline was observed in 55.9% of cases, while mortality and disability were noted in 5.38% and 38.7% of cases, respectively. For 17 cases, aetiology and duration significantly impacted patient outcomes (P <0.05).
CONCLUSION: Acute symptomatic status is the most common aetiology of CSE. A longer duration of CSE is associated with higher mortality and neurological disability. Prompt and appropriate management of CSE is essential. Furthermore, identifying and treating the underlying cause of CSE is a crucial step in reducing its duration and improving patient outcomes.
<P>PROBLEM TO BE SOLVED: To obtain a photopolymerizable composition having a low polymerization shrinkage and excellent fluidity even when the compounding ratio of an inorganic filler is relatively high in order to provide excellent mechanical properties of a cured product after curing, and suitably usable as a flowable composite resin.  <P>SOLUTION: This dental photopolymerizable composition comprises 100 pts. mass of a polymerizable monomer, 100-400 pts. mass of the inorganic filler and an effective amount of a photopolymerization initiator. In the dental photopolymerizable composition, ≥60 mass% of particles having ≥0.03 to <0.1 μm particle diameter in the inorganic filler are silica-zirconia spherical inorganic oxide particles.  <P>COPYRIGHT: (C)2005,JPO&NCIPI
HEIRS included a cross-sectional screening study of 101,168 patients, 25 years of age or older, in the primary care setting. Participants were recruited from four centers in the U.S .and one in Canada from February 2001 to February 2003. We will evaluate results for women aged 25-44 years of age who are self-reported as Asian, Black, Hispanic or White. The lower detection limit for the serum ferritin (SF) assay in the HEIRS study was 15 μg/L and therefore the definition of iron deficiency will be SF concentration ≤ 15 μg/L. Elevated SF concentrations, possibly indicative of elevated iron stores, will be classified by two definitions: 1) SF concentration \> 300 μg/L and 2) SF \>200 μg/L in combination with TSAT \>45%. Proportions will be compared by Pearson's chi-square. Logistic regression models will be used to identify independent associations with measures of iron deficiency and elevated iron stores.
It is often difficult to manage acute painful crisis in patients with sickle cell disease. The usual management of these crises relies on hydration, administration of oxygen and narcotics, like morphine. A select group of patients, for unknown reasons, does not respond to this management and these patients often require prolonged use (several days) of intravenous narcotics. Narcotics have proven to be ineffective in controlling this type of pain and can cause multiple side effects (sedation, vomiting, respiratory depression). We propose to administer intravenous ketamine in this group of patients who are resistant to intravenous narcotics. Ketamine has been proven to be effective in controlling pain in multiple clinical situations. However, there are no data in the literature describing its use in patients with sickle cell disease.
BACKGROUND: Primary aldosteronism, characterized by overt renin-independent aldosterone production, is a common but underrecognized form of hypertension and cardiovascular disease. Growing evidence suggests that milder and subclinical forms of primary aldosteronism are highly prevalent, yet their contribution to cardiovascular disease is not well characterized.
METHODS: This prospective study included 1284 participants between the ages of 40 and 69 years from the randomly sampled population-based CARTaGENE cohort (Québec, Canada). Regression models were used to analyze associations of aldosterone, renin, and the aldosterone-to-renin ratio with the following measures of cardiovascular health: arterial stiffness, assessed by central blood pressure (BP) and pulse wave velocity; adverse cardiac remodeling, captured by cardiac magnetic resonance imaging, including indexed maximum left atrial volume, left ventricular mass index, left ventricular remodeling index, and left ventricular hypertrophy; and incident hypertension.
RESULTS: The mean (SD) age of participants was 54 (8) years and 51% were men. The mean (SD) systolic and diastolic BP were 123 (15) and 72 (10) mm Hg, respectively. At baseline, 736 participants (57%) had normal BP and 548 (43%) had hypertension. Higher aldosterone-to-renin ratio, indicative of renin-independent aldosteronism (ie, subclinical primary aldosteronism), was associated with increased arterial stiffness, including increased central BP and pulse wave velocity, along with adverse cardiac remodeling, including increased indexed maximum left atrial volume, left ventricular mass index, and left ventricular remodeling index (all P<0.05). Higher aldosterone-to-renin ratio was also associated with higher odds of left ventricular hypertrophy (odds ratio, 1.32 [95% CI, 1.002-1.73]) and higher odds of developing incident hypertension (odds ratio, 1.29 [95% CI, 1.03-1.62]). All the associations were consistent when assessing participants with normal BP in isolation and were independent of brachial BP.
CONCLUSIONS: Independent of brachial BP, a biochemical phenotype of subclinical primary aldosteronism is negatively associated with cardiovascular health, including greater arterial stiffness, adverse cardiac remodeling, and incident hypertension.
The invention relates to a preparation method of carbon quantum dots for treating chronic refractory infection wounds, which comprises the steps of preparing carbon sources of the carbon quantum dots, mixing human tissue cells with a solvent, heating the mixture by using microwaves, filtering and dialyzing to obtain dialysate, namely an aqueous solution of the carbon quantum dots, and drying the dialysate to obtain powdery carbon quantum dots. Wherein, human tissue cells are used as a carbon source to prepare the carbon quantum dots, so that the homology of the carbon quantum dots is ensured, and the immune interference during the treatment period is reduced. The carbon quantum dots are prepared by adopting human living tissues or living cells as a carbon source and adopting a simpler one-step microwave-assisted heating method. The carbon quantum dots are subjected to in-situ surface modification by utilizing amino acids and other components in cell sap and tissue sap which have antibacterial properties or are beneficial to antibacterial property so as to realize ultrahigh positive electricity functionalization. The carbon quantum dots can perform fluorescence red shift (even emit red light) by utilizing the hemoglobin existing in the cell fluid or tissue fluid to participate in the in-situ reaction, so that the carbon quantum dots can be greatly promoted to play a role in the therapeutic window of 700 to 1300 nm. The synthesized carbon quantum dots have the advantages of good biocompatibility, drug resistance, antibiosis, biofilm resistance, cell nontoxicity, targeting selectivity, simple process, low cost, no skin irritation and environmental friendliness.
PURPOSE:To treat diseases due to trichophytes, viruses, bacteria, etc. parasitic on domestic animals, by using a gasified vapor of dichlorobenzene. CONSTITUTION:The respiratory action of the skin and sterilizing action of dichlorobenzene are used to treat completely athlete's foot caused by trichophytes. For example, an adequate amount of the dichlorobenzene is put into the interior of socks or inner soles of air-permeable sponge gourd, etc. For ring worms grown between fingers, p-dichlorobenzene is wrapped in air-permeable cotton, and nipped between the fingers to wear the socks or gloves thereon. After completing the work for a day, etc., hands and feet are washed with an aqueous solution of an SIT pharmaceutical. The continuation of the above-mentioned method for 3-4 days permits the itching of the athlete's foot ring worm to disappear and to cure.
Physical dependence, psychological dependence, and abuse have occurred. When chronic intoxication from prolonged use occurs, it usually involves ingestion of greater than recommended doses and is manifested by ataxia, slurred speech, and vertigo. Therefore, careful supervision of dose and amounts prescribed is advised, as well as avoidance of prolonged administration, especially for alcoholics and other patients with a known propensity for taking excessive quantities of drugs.

Sudden withdrawal of the drug after prolonged and excessive use may precipitate recurrence of pre-existing symptoms such as anxiety,anorexia, insomnia, or withdrawal reactions such as vomiting, ataxia,tremors, muscle twitching, confusional states, hallucinosis, and rarely, convulsive seizures. Such seizures are more likely to occur in persons with central nervous system damage or pre-existent or latent convulsive disorders. Onset of withdrawal symptoms occurs usually within 12 to 48 hours after discontinuation of meprobamate;symptoms usually cease within the next 12 to 48 hours.

When excessive dosage has continued for weeks or months, dosage should be reduced gradually over a period of one or two weeks rather than abruptly stopped. Alternatively, a long-acting barbiturate may be substituted, then gradually withdrawn.
Study period: 6 months No. of sessions: 2 sessions (at month 1 and 3) Mode: Face-to-face Where: At the participant's home Duration of session: 20- 30 minutes Details of control: physical activity information without any other support.
The invention discloses a juice mask making machine. The aim of the invention is to provide a convenient and fast juice mask making machine. The machine comprises a shell, a bottom shell, a juice outlet and a material inlet, a juice extractor is arranged below the material inlet, two ends of the juice extractor are a juice outlet end and a mask outlet end respectively, a mask cavity is arranged below the mask outlet end, the upper end of the mask cavity is provided with a mask discharging probe, the lower end of the mask cavity is provided with a mask cavity discharging probe, a mask cavity outlet is arranged below the mask cavity discharging probe, the lower end of the mask cavity outlet is provided with a mask tray below the bottom shell, a juice outlet probe is arranged between the juice outlet and the juice outlet end, and the upper end of the mask tray is provided with an oscillating motor. Each of the juice outlet probe, the mask outlet probe and the mask cavity discharging probe is an electric induction probe. Each of the outer shell, the bottom shell and the mask cavity is made of a plastic. The machine is mainly used for fruit juice extraction and beauty treatment.
Subject in Arm B are patients who have failed only one prior alkylating chemotherapy regimen and have gone at least 12 months since the last treatment. Subjects in Arm B will receive 28-day cycles of treatment, with ATRA 45mg/m2/day given orally in two equally divided doses on days 1 through 14 and retifanlimab 500mg IV on day 1.
Respiratory plasticity is a beneficial response to chronic hypoxia in fish. Red drum, a teleost that commonly experiences hypoxia in the Gulf of Mexico, have shown respiratory plasticity following sublethal hypoxia exposure as juveniles, but implications of hypoxia exposure during development are unknown. We exposed red drum embryos to hypoxia (40% air saturation) or normoxia (100% air saturation) for 3 days post fertilization (dpf). This time frame encompasses hatch and exogenous feeding. At 3 dpf, there was no difference in survival or changes in size. After the 3-day hypoxia exposure, all larvae were moved and reared in common normoxic conditions. Fish were reared for ∼3 months and effects of the developmental hypoxia exposure on swim performance and whole-animal aerobic metabolism were measured. We used a cross design wherein fish from normoxia (N=24) were exercised in swim tunnels in both hypoxia (40%, n=12) and normoxia (100%, n=12) conditions, and likewise for hypoxia-exposed fish (n=10 in each group). Oxygen consumption, critical swim speed (Ucrit), critical oxygen threshold (Pcrit) and mitochondrial respiration were measured. Hypoxia-exposed fish had higher aerobic scope, maximum metabolic rate, and higher liver mitochondrial efficiency relative to control fish in normoxia. Interestingly, hypoxia-exposed fish showed increased hypoxia sensitivity (higher Pcrit) and recruited burst swimming at lower swim speeds relative to control fish. These data provide evidence that early hypoxia exposure leads to a complex response in later life.
The invention relates to a drug composition containing various lipid-soluble vitamins. The composition contains 600-750mg of vitamin A palmitate, 1.5-12mg of vitamin D2, 3000-8000mg of vitamin E, 50-1200mg of vitamin K1 and 10-100g of Tween-80. The composition can be prepared into freeze-dried powder injection or injection. The composition containing various lipid-soluble vitamins is small in auxiliary dosage and is safe and effective in clinical use. The preparation prepared from the composition has good drug stability. Stability tests prove that the preparation is stable in contents of active ingredients of the drug and is more suitable for clinical application.
Human monoclonal antibodies which bind specifically to Fc alpha receptor (CD89), including monoclonal antibodies which react specifically to Fc receptor for IgA of human effector cells are disclosed. The binding agents, e.g., antibodies are useful for targeting human effector cells (e.g. macrophages) against a target cell (e.g. a cancer cell, an infectious agent, etc.). for this purpose, bifunctional antibodies or heteroantibodies can be constructed containing the binding region derived from an anti-Fc-alpha receptor antibody and the binding region of a target-specific antibody. Targeted effector cells can specifically lyse target cells.
PURPOSE:To obtain a cosmetic having anti-inflammatory effect by compounding potassium alum and an acid. CONSTITUTION:The objective product can be produced by compounding a cos metic with 0.001-10wt.% of potassium alum and 0.001-10wt.% of an acid. The cosmetic used as a base is a processed product derived from oils and fats, waxes, hydrocarbons, fatty acids, alcohols, esters, amine-amide or metallic soap, a processed oil and fat product such as surfactant, a perfumery, a gum, a water-soluble polymer or vitamins. The cosmetic can be used in the form of face lotion, milky lotion, cream, lip cream, rouge, foundation, perfumery, eau de Cologne, etc. The anti-inflammatory effect is an action to suppress the inflammation causing the skin eruption such as pimple, folliculitis, rash, heat rashes, etc. Potassium alum is a compound having a chemical name of aluminum potassium sulfate. The acid to be used in the above cosmetic is carboxylic acid or amino acid.
Enrolled subjects will receive FICB with 50cc of 0.3% ropivacaine. Blocks will be performed under an ultrasound guidance device with an in-plane technique by a single study investigator, in the preoperative area.
The present invention addresses the problem of providing a cyclic peptide or salt thereof having excellent cell membrane permeability and excellent target bindability with MDMX, and an MDMX inhibitor. The present invention provides a cyclic peptide, or a salt thereof, which is represented by formula (1) defined in the specification of the present application, and which has features (a)-(d) below. (a) The cyclic peptide has a structure in which, when a is taken to be the axial length in the axial direction of the longest main chain structure and b and c are taken to be the axial lengths in two other directions which are orthogonal to a and orthogonal to each other, and the ellipsoid approximation is performed to determine the axial lengths for a, b, and c, and through this approximation stage, the molecular shape factor r is calculated using formula (2), r ranges from 0.4 to 0.6. (b) The aforementioned peptide is nonionic under a physiological environment. (c) The proportion of the number of N-substituted amino acids to the total number of amino acids in the aforementioned peptide is 25% or more. (d) The aforementioned peptide includes 1-3 amino acid residues and amino acid analogue residues having an aromatic carbocyclic group or an aromatic heterocyclic group in a side chain.
Globally, there is a growing concern about tree mortality due to harsh climates and changes in pest and disease patterns. However, experimental studies on the interactions between biotic and abiotic stresses in plants are relatively scarce. In this study, we investigated the interaction between Fusarium solani and water-stressed Dalbergia sissoo saplings. We postulated that under drought conditions, sissoo plants would become more susceptible to dieback infestation. Five fungi, including Fusarium oxysporum, Curvularia lunata, Cladophialophora carrionii, Alternaria alternaria, and Fusarium solani, were isolated from an old shisham tree showing advanced symptoms of dieback infestation. These fungi were identified based on their ITS sequence homology and spore characteristics. Dieback development was more pronounced in plants experiencing water stress, regardless of their predisposition or whether it occurred simultaneously. Lesions were more noticeable and longer in predisposed saplings (3.8cm), followed by simultaneous (2.4cm) and much smaller lesions in seedlings that were inoculated and well-watered (0.24cm). Progressive browning of the upper leaves, which lowers sapling height in predisposed, simultaneous, and well-watered inoculated saplings to 8.09 inches, 5.93 inches, and 17.42 inches, are typical dieback symptoms. Water stress causes the loss of chlorophyll a, b, and carotenoids, which reduces stomatal conductance, transpiration rate, and photosynthetic activity, leading to poor development and mortality. Similarly, predisposed, simultaneous, and well-watered inoculated seedlings expressed increased activity of CAT (22.57, 18.148, and 9.714 U/mg) and POD (3.0, 4.848, 1.246 U/mg), to reduce the damage caused by elevated levels of H2O2 expression. It is concluded that water stress is the main cause of dieback in shisham saplings that subsequently disposed of infected seedlings to secondary agents such as fungi and insects in the advanced stages of the dieback with prolonged drought stress. The lack of dieback in native populations is attributed to the absence of several ecological stresses, including water stress, extended droughts, waterlogging, and salinity. This study emphasizes the need for additional research into the effects of abiotic factors linked with fungal diseases on the long-term production and management of D. sissoo in Pakistan.