anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Standard PDT using topical aminolevulinate followed by red light illumination for actinic keratosis. A region of interest (ROI) on the skin of the arms, hands, legs, or feet will be selected for monitoring. This ROI will be marked and baseline measurements will be taken. The topical drug Levulan (ALA) will be applied to the ROI and other areas being treated, and covered with plastic wrap. Prior to red light illumination, post topical measurements and baseline values will be performed to measure PpIX and sO2. Red light illumination will follow, and sO2 phosphorescence will be recorded continuously from the ROI. After, a post-PpIX measurement will be taken.
S-1 ( 40 mg/m2 bid po d1-14) and Penpulimab (200mg ivgtt d1) and Oxaliplatin ( 130 mg/m2 (d1) The treatment period of the above drugs was 3 weeks, and the duration of preoperative treatment was 3 cycles. After treatment, the patient underwent surgery after evaluation. Four cycles of adjuvant therapy with the original regimen (preoperative) were performed after surgery.
A removable sponge for intravaginal administration in domestic animals is impregnated with at least an ovulation-controlling dosage of a progestational compound, which dosage may permit the induction of ovulation at a determinable period after discontinuance of its use.  The fertility of domestic animals may be controlled by intravaginal administration of the impregnated sponge, followed by removal of the sponge prior to the time that insemination of the animal is to occur.  Animals that may be so treated include domestic farm animals, for example ewes, cows, sows, mares and goat does, and domestic pets, for example dog bitches and cats; examples describe the treatment as applied to ewes and cows.  The sponge may be made of relatively elastic, porous and absorptive plastics materials, especially polyurethanes of the polyester or polyether type; the sponge material may also be natural sponge, natural or synthetic rubber, polyvinylchloride and polyethylene.  A string may be attached to the sponge to facilitate removal.  Linen, cotton, nylon, polyolefine and polyester fibre strings may be used; monofilaments of nylon or polypropylene are preferred.  Suitable sizes and shapes for the sponge are given in the Specification.  Suitable progestational compounds include steroidal and non-steroidal compounds which are capable of controlling ovulation, for example progesterone and related compounds; numerous examples of such compounds are listed in the Specification.  The impregnated sponge may be prepared by dissolving the progestational compound, for example 17a -acetoxy-9a -fluoro-11b -hydroxypregn-4-ene-3,20-dione, in a low boiling point solvent, for example ethanol, applying the resulting solution to the sponge, and allowing the solvent to evaporate.  Antibiotics and bacteriostats, estrogens or androgens may be added to the sponge before or after impregnation.  The sponge may be inserted by hand or with the aid either of a duckbilled speculum and plastic rod or of a tapered plastics tube applicator and plastic rod.
Portal hypertension is a condition that is caused by various disorders of the liver, including cirrhosis, hepatitis, portal vein thrombosis, or Budd-Chiari Disease. Portal hypertension can lead to the accumulation of fluid in the abdomen, called ascites, or put patients at risk for bleeding of the esophagus, stomach, and bowel. In certain patients, portal hypertension is treated by placement of a Transjugular Intrahepatic Portosystemic Shunt (TIPS).

Elastography is a newer exam which measures the consistency, or softness/stiffness, of various organs in the body. It is performed with ultrasound by sliding a transducer across the abdomen. Elastography is most commonly used to evaluate the liver, as disorders that cause damage to the liver result in stiffer liver tissue. The spleen has also been shown to get stiffer in the setting of portal hypertension.
According to one embodiment, a magnetic sensor includes a first sensor element and a first interconnect. The first sensor element includes a first magnetic layer, a first opposing magnetic layer, and a first nonmagnetic layer provided between the first magnetic layer and the first opposing magnetic layer. A first magnetization of the first magnetic layer is aligned with a first length direction crossing a first stacking direction from the first magnetic layer toward the first opposing magnetic layer. At least a portion of the first interconnect extends along the first length direction. The first interconnect cross direction crosses the first length direction and is from the first sensor element toward the portion of the first interconnect. A first electrical resistance of the first sensor element changes according to an alternating current flowing in the first interconnect and a sensed magnetic field applied to the first sensor element.
BACKGROUND: Chronic graft-versus-host disease (cGvHD) is a major cause of morbidity and mortality after Hematopoietic Stem Cell Transplantation (HSCT). Previously, in large patient cohorts, we identified increased numbers of CD56brightPerforin- regulatory-like NK cells (NKreg-like) associated with cGvHD suppression. Thus, we hypothesized that NKreg-like cells may be a potential candidate for cGvHD cell therapy.
AIM: To expand NKreg-like cells while maintaining regulatory phenotype and function.
METHODS: Total NK cells were first expanded with IL-2, which was then combined with rapamycin, Transforming Growth Factor Beta 1 (TGF-β1), NECA (Adenosine A2A receptor (A2AR) agonist), metformin, or dexamethasone, to prevent change in cell phenotype/function. The functional characteristics were evaluated via T cell suppression assays and the phenotype was measured using flow cytometry. The optimal expansion protocol was compared in terms of function and metabolism for three NK expansion media, and cells from cord vs. peripheral blood. Further, expanded NKreg-like cell gene expression was characterized using bulk RNA sequencing. Finally, NKreg-like cells were differentiated from CD34+ hematopoietic stem and progenitor cells (HSPCs) and compared in terms of proliferation and function.
RESULTS: The expansion of total NK cells found the addition of TGF-β1 and/or NECA with the pulsing of rapamycin in IL-2 containing media to prevent NKreg-like differentiation (up to 200-fold expansion). Expanded NKreg-like cells maintained a phenotype, transcriptome, and T cell suppression similar to freshly isolated NKreg-like cells. NKreg-like expansion was greatest in the Immunocult media (up to 300-fold), and NKreg-like cells from peripheral blood demonstrated significantly greater proliferation than cells isolated from cord blood (65-fold). The metabolic profile of NKreg-like and cytolytic NK cells appeared similar at baseline, though rapamycin induced a shift to oxidative over glycolytic metabolism. Further, we demonstrated that suppressive NKreg-like cells may alternatively be expanded from CD34+ cells isolated from cord blood, reaching an average 340-fold expansion.
CONCLUSIONS: In conclusion, our studies have optimized two alternative expansion approaches for deriving functional NKreg-like cells. Additionally, evaluating the transcriptomic and metabolic characteristics provides useful information regarding NKreg-like cell function and differentiation. With further optimization and in vivo validation, we may work towards preparing these cells as a therapy for cGvHD.
The present invention relates to a dynamic threshold adjustment system of a physiological signal measurement device. The system comprises a wearable physiological signal measurement device and a back-end analysis device for dynamically adjusting the judgment threshold for electrocardiogram measurement. The present invention can measure the electrocardiogram and store the electrocardiogram in real time to establish big data of physiological signals. At the same time, the system can generate an alarm message and remind for a doctor appointment based on a preliminary disease judgment made according to a disease judgment threshold. The big data of physiological signals is used to dynamically adjust the disease judgment threshold and improve the objectivity of disease judgment. The measured electrocardiogram is provided for the doctor's reference during the follow-up visit to the doctor. The wearable physiological signal measurement device is used for a user to wear and accurately measure to generate a measurement data, perform a detection process according to the judgment threshold, and convert the measurement data that exceeds the judgment threshold into a physiological signal data. The judgment threshold and the physiological signal data are transmitted via a wireless method. The back-end analysis device receives the judgment threshold and the physiological signal data through a wireless method, stores the judgment threshold and the physiological signal data to establish big data of physiological signals, and performs a judgment process according to the big data of physiological signals to determine whether the alarm message is generated and transmitted or not. Otherwise, it will generate a dynamic adjustment process for adjusting, updating and transmitting the judgment threshold to the wearable physiological signal measurement device. The wearable physiological signal measurement device converts the measurement data into the physiological signal data and transmits it when an average value of the measurement data exceeds the judgment threshold. The dynamic adjustment process is further used to update the judgment threshold of the wearable physiological signal measurement device.
BACKGROUND: COVID-19 pandemic has immensely impacted the social and personal lives of individuals around the globe. Marginalized-related diminished returns (MDRs) theory suggests that educational attainment shows a weaker protective effect for health and behavioral outcomes for Black individuals compared to White individuals. Previous studies conducted before the COVID-19 pandemic demonstrated diminished returns of educational attainment for Black individuals compared to White individuals.
OBJECTIVES: The study has three objectives: First, to test the association between educational attainment and cigarette smoking, e-cigarette vaping, presence of chronic medical conditions (CMC), self-rated health (SRH), depressive symptoms, and obesity; second, to explore racial differences in these associations in the USA during the COVID-19 pandemic; and third, to compare the interaction of race and return of educational attainment pre- and post-COVID-19 pandemic.
METHODS: This study utilized data from the Health Information National Trends Survey (HINTS) 2020. Total sample included 1313 adult American; among them, 77.4% (n = 1017) were non-Hispanic White, and 22.6% (n = 296) were non-Hispanic Black. Educational attainment was the independent variable operationalized as years of education. The main outcomes were cigarette smoking, e-cigarette vaping, CMC, SRH, depressive symptoms, and obesity. Age, gender, and baseline physical health were covariates. Race/ethnicity was an effect modifier.
RESULTS: Educational attainment was significantly associated with lower CMC, SRH, depressive symptoms, obesity, cigarette smoking, and e-cigarette vaping. Educational attainment did not show a significant interaction with race on any of our outcomes, suggesting that the health returns of education is similar between non-Hispanic White and non-Hispanic Black individuals.
CONCLUSION: COVID-19 may have operated as an equalizer of the returns of educational attainment. This observation may be because White may have more to lose; Black communities may be more resilient or have economic and social policies that buffered unemployment and poverty regardless of historical anti-Black oppression.
The Hans Kai trial will follow a prospective mixed methods intervention design involving an RCT and an interpretative descriptive qualitative study. The mixed methods intervention design is a mixed methods approach to research in which the collection, analysis, and integration of both quantitative and qualitative data are embedded within an experimental quantitative research design. The objective of gathering qualitative data within an experiment, along with the quantitative data on the outcome measures, is to gain an understanding of the personal, contextual experiences of the study participants.

In this mixed methods intervention study design, quantitative data on the outcomes of interest will be collected along with qualitative data on the experiences of program participants and facilitators, and integrated within an intervention trial (i.e., RCT) to address the research objectives (see next section for details). The primary research design in this study will be a quantitative intervention trial or RCT that will follow a pragmatic randomized wait-list-control design with an 18-month follow-up. The RCT will involve the collection, analysis, and interpretation of quantitative data (self-reports and objective indicators) on primary, secondary, and tertiary outcomes that will be gathered to evaluate the effectiveness of the Hans Kai program in promoting the health and wellbeing of Canadian adults. To enrich the RCT results, the secondary qualitative strand of the study will be added during and after the intervention by embedding a combination of convergent and explanatory sequential designs into the RCT.
This study will be randomized clinical trial used to compare the effects of Perturbation and trunk control training in children with Cerebral Palsy. Subjects meeting the predetermined inclusion and exclusion criteria will be divided into two groups using lottery method. Pre-assessment will be done using Berg balance scale, functional Independent measures and TUG test as objective measurements. Subjects in one group will be treated using Perturbation therapy and the other one will be treated with Trunk control training. Both groups had three treatment sessions per week, for 4 weeks, and the total time for every session was about 30-45 minutes. A postural perturbation refers to unexpected change in conditions that upsets the body's harmony and displaces its posture. These perturbations can be sensory in nature, such as vestibular perturbations resulting from electrical stimulation, visual perturbations caused by a moving room or graphical images, or somatosensory perturbations caused by muscle vibrations. The body's reactions to these sensory perturbations may be based on the perception of instability rather than actual imbalance. On the other hand, "mechanical perturbations" physically displace the body segments, potentially leading to a shift in the overall center of mass or actual imbalance. Even small displacements of a single body segment, like the head, can elicit minor muscle responses throughout the body
In Cohort B, carboplatin and paclitaxel chemotherapy will be administered after atezolizumab and tiragolumab IV infusion. During induction phase, participants will receive atezolizumab and tiragolumab in combination with carboplatin and paclitaxel on Day 1 of each 21-day cycle for 4 to 6 cycles. During maintenance phase, participants will receive atezolizumab and tiragolumab on Day 1 of each 21-day cycle (participants enrolled under protocol version 4) or Day 1 of each 28-day cycle (participants enrolled under protocol version 5).
PCT No. PCT/FR98/00080 Sec. 371 Date Oct. 21, 1998 Sec. 102(e) Date Oct. 21, 1998 PCT Filed Jan. 16, 1998 PCT Pub. No. WO98/31329 PCT Pub. Date Jul. 23, 1998The present invention is directed to cosmetic or dermatological compositions comprising, in a cosmetically acceptable aqueous medium, as an agent for coating keratin fibres, from 15 to 60% by weight of solids of a film-forming mixture comprising: (A) at least one aqueous dispersion of polymer particles which can form a film by themselves or can form a film in the presence of at least one plasticizer; the glass transition temperature Tg of the polymer or of the polymer/plasticizer mixture being less than or equal to 25 DEG  C.; and (B) at least one aqueous dispersion of spherical or anisotropic, non-film-forming particles capable of forming a percolation network in the matrix of the film formed from the film-forming particles and from the optional plasticizer; the said non-film-forming particles are different from the pigments and are present in the said film-forming mixture in concentrations ranging from 20 to 90% by volume when they are spherical and in concentrations ranging from 10 to 80% by volume when they are anisotropic. These compositions can be used as bases for make-up products for the eyelashes and the eyebrows, or as bases for hair products for styling and/or maintaining the hair.
For most cases of neck pain, the risk factors are multifactorial, and clear pathophysiological mechanisms are lacking. Treatment efforts aim to alleviate symptoms in the absence of causal treatment alternatives, while rehabilitation programs enhance the functional status. Therefore, it is imperative to have validated questionnaires to measure pain, other symptoms, and functional limitations in neck pain disorders, both for characterizing the patient group and evaluating rehabilitation efforts. The Alfta Rehab Center developed the Profile Fitness Mapping for Neck (ProFitMap-neck) questionnaire between 1992 and 1994, which comprises two scales for assessing self-estimated symptoms and functional limitations resulting from neck problems. The symptom scale comprises two indices, representing the intensity and frequency of the symptoms, while the functional limitation scale produces a single function index. The current study describes and evaluates the reliability and validity of a Profile Fitness Mapping Neck questionnaire (ProFitMap-neck) to assess the symptoms and functional limitations of Pakistani people with chronic neck pain. There is no clear evidence that orphenadrine's antimuscarinic activity is related to its antinociceptive action, although its mild antihistaminic activity may play a role. Histamine can stimulate nociceptors, and histamine receptors are found in brain tissue and primary afferent neurons. Unlike the other muscle relaxants, orphenadrine produces some independent analgesic effects that may contribute to its efficacy in relieving painful skeletal muscle spasm. Paracetamol/acetaminophen is one of the most popular and commonly used analgesic and antipyretic drugs in the world, available without a prescription in both mono- and multi-component preparations. Patients who cannot receive treatment from non-steroidal anti-inflammatory drugs (NSAIDs), such as those with bronchial asthma, peptic ulcer disease, hemophilia, salicylate-sensitized individuals, or pregnant or breastfeeding women, opt for this drug. The mechanism of action is complex and includes the effects of both the peripheral (COX inhibition) and central (COX, serotonergic descending neuronal pathway, L-arginine/NO pathway, cannabinoid system) antinociception processes, as well as redox mechanisms that block the production of chemicals in the body that are responsible for pain. Paracetamol is a well-tolerated drug and produces few side effects from the gastrointestinal tract. The non-clinical data demonstrated that orphenadrine is a mild antinociceptive agent similar to non-opioid analgesics. There are clear indications that the combination with Paracetamol may provide increased antinociceptive activity and duration of action over and above Orphenadrine or Paracetamol alone.
BACKGROUND: The risk of developing dementia is higher in individuals who suffer from perioperative neurocognitive disorder (PND), including postoperative cognitive dysfunction (POCD) and delirium. Recent studies have indicated correlations between anesthesia, surgery and PND. Acute metabolic changes induced by anesthesia and surgery may be related to cognitive impairments. Despite a paucity of research on acute metabolic changes in the hippocampus during surgery, there are conflicting about specific metabolites.
METHODS: We developed a mouse model of cognitive impairment induced by isoflurane anesthesia and unilateral nephrectomy. Cognition was evaluated by Y maze and fear conditioning test (FCT). The hippocampus was harvested after the surgery. LC-MS (liquid chromatography-mass spectrometry) was performed. The differential metabolites involved in lipid, amino acid, nucleotide, carbohydrate metabolism were analyzed.
RESULTS: Anesthesia and surgery exposure induced cognition decline. A total of 49 metabolites were significantly up-regulated and 122 down-regulated. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of the metabolites identified purine, glutathione, nicotinate and nicotinamide metabolism. Metabolites involved in lipid, amino acid, nucleotide, carbohydrate metabolism were identified including nicotinamide adenine dinucleotide (NAD), 1-Methylnicotinamide, propionic acid, histidine, adenosine, and guanosine cyclic monophosphate. Some metabolites exhibited a consistent change trend in the hippocampus of aging mice.
CONCLUSIONS: The study indicates that anesthesia and surgery can induce acute alterations in hippocampal metabolomics, including metabolites involved in lipid, amino acid, nucleotide, and carbohydrate metabolism. These metabolites may play a role in modulating PND through the regulation of neuroinflammation, oxidative stress, blood-brain barrier (BBB) permeability.
Bharat Biotech International Ltd's new Rotavirus vaccine, ROTAVAC 5D is a live, attenuated G9P\[11\] monovalent vaccine at a dose of 0.5mL containing NLT log 10\^5.0 focus forming units (FFU) per dose. 5D is in liquid form.
Vaccine compsn. comprises avirulent canine coronavirus and a carrier, in a dosage unit effective to protect a dog from infection by the coronavirus. - The dose is such that at least 1000 virus particles (by FAID 50) are present. The coronavirus may modified live virus or inactivated. virus. Suitable at least 3.3 logs of particles are present per dose (by FAID 50). A canine parvovirus vaccine may also be present; opt. canine distemper virus, canine parainfluenza virus, canine adenovirus I and II vaccines may also be present. - The coronavirus has a pre-inactivation litre of at least 10000 particles/ml. esp. 10000-10millin. The vaccine may contain as adjuvant ethylene-maleic anhydride or a copolymer of styrene and acrylic acid-methoacrylic acid. Suitable coronavirus ATCC No. VR 2068 is used. - The attenuated and inactivated vaccine induces both systemic and local immunity in the intestinal tract of dogs after parenteral admin. The vaccine is as effective as the known modified live canine coronavirus vaccine. EPAB- EP-145783 B A vaccine composition comprising the avirulent antigenic product produced by either (a) attenuating  live Canine Coronavirus by passage through cells of feline origin such that when administered to a dog by injection the attenuated live virus selectively infects the intestinal epithelium, or (b) inactivating feline or canine cell propagated Canine Coronavirus, the avirulent antigenic product being pressed in an amount effective to protect a dog from infection by virulent Canine Coronavirus; and a non-toxic pharmaceutically acceptable carrier. - (43pp)i USAB- US4567042 A Vaccine compsn. comprises inactivated canine coronavirus (pre-activation titre at least 10,000 canine coronavirus particles per cm3), dispersed with a diluent, e.g. ethylene or maleic anhydride polymers or copolymers of styrene with mixts. of acrylic and methacrylic acids, and a veterinary carrier.