anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Colonic diverticulosis is the most common structural abnormality of the colon and studies suggest that its incidence and/or complications are increasing. Increasing evidence suggests a link between obesity and complications of diverticular disease. With the prevalence of obesity increasing in westernised populations, the risk of complications from diverticular disease is likely to also increase. At present however, there is little understanding of how diverticular complications are increased by obesity. A high BMI might be a surrogate marker for other lifestyle factors which predispose to diverticular complications. Visceral fat may also have an influence on related complications, due to the compounds secreted by adipocytes.

Altered bowel habit is a common complaint of diverticular patients. The cause is not well understood, is probably multi-factorial, and may include changes in the small bowel. Until recently, studies of the large and small bowel required intestinal intubation and perfusion and could not be performed on the undisturbed colon. New MRI techniques have now been developed, which allow these areas to be studied non-invasively. Abdominal fat can also be measured using MRI, and the distribution of subcutaneous and visceral fat will be compared for symptomatic and asymptomatic diverticular patients.
310,919. Milnesia International, Inc., (Assignees of McGowan, TV. C.). May 3, 1928, [Convention date]. Medicines for internal use.-Magnesium hydrate, which may contain magnesium oxide or carbonate, is granulated while moist, and after drying, made into medicinal tablets. Diluents such as calcium carbonate, starch or sugar of milk, a sweetening agent such as saccharin, and a binding agent such as gum acacia may be added before granulation, and the latter be effected by passing the composition through a sieve whilst spraying with a flavouring agent such as methyl salicylate.
PROBLEM TO BE SOLVED: To make it possible to generate and manage medical consultation data for every patient by providing a means which retrieves medical consultation information on an arbitrary patient from a managed data base, a means which selects necessary information out of the information, and a means which generates medical consultation data from the selected medical consultation information and registers it. SOLUTION: Patient's basic information supplied from an input device 3 is supplied to the data retrieval means 21. The data retrieval means 21 retrieves medical consultation information from a department system 1 by using the supplied information as a key. Further, medical consultation support data is retrieved from a magnetic disk drive 52 and supplied to a data display means 22. The data display means 22 displays the medical consultation information and medical consultation support data on a display 51 and stores them in a medical consultation information storage part 41 and a medical consultation support data storage part 42 respectively. A data editing means 23 selects necessary information out of the medical consultation information displayed on the display 51 and stores it in the medical consultation support data storage part 42.  The data registering means 24 outputs those data to the magnetic disk drive 52.
Risk stratification using genetics and minimal residual disease has allowed for an increase in the cure rates of pediatric acute myeloid leukemia (pedAML) to up to 70% in contemporary protocols. Nevertheless, ∼30% of patients still experience relapse, indicating a need to optimize stratification strategies. Recently, long noncoding RNA (lncRNA) expression has been shown to hold prognostic power in multiple cancer types. Here, we aimed at refining relapse prediction in pedAML using lncRNA expression. We built a relapse-related lncRNA prognostic signature, named AMLlnc69, using 871 transcriptomes of patients with pedAML obtained from the Therapeutically Applicable Research to Generate Effective Treatments repository. We identified a 69 lncRNA signature AMLlnc69 that is highly predictive of relapse risk (c-index = 0.73), with area under the receiver operating characteristic curve (AUC) values for predicting the 1-, 2-, and 3-year relapse-free survival (RFS) of 0.78, 0.77, and 0.77, respectively. The internal validation using a bootstrap method (resampling times = 1000) resulted in a c-index of 0.72 and AUC values for predicting the 1-, 2-, and 3-year RFS of 0.77, 0.76, and 0.76, respectively. Through a Cox regression analysis, AMLlnc69, nucleophosmin mutation, and white blood cell at diagnosis were identified as independent predictors of RFS. Finally, a nomogram was build using these 2 parameters, showing a c-index of 0.80 and 0.71 after bootstrapping (n = 1000). In conclusion, the identified AMLlnc69 will, after prospective validation, add important information to guide the management of patients with pedAML. The nomogram is a promising tool for easy stratification of patients into a novel scheme of relapse-risk groups.
Participants in the placebo control group will receive no jogging and melatonin supplement dosing activity. However, they will be given a placebo flavored similar to the melatonin supplement (compounded by Pharmacare, Mt. Juliet, NT®). Meanwhile, they will also be required to wear an actigraph to control for their physical activity level at the assessment points (i.e. T1, T2, and T3). They will be expected for following their daily routine without participating in any additional formal physical exercise training program throughout the whole study period (T1-T3). After T3, they will be assisted with jogging program to recognize their contribution as controls.
OBJECTIVES: The aim of this study was to discuss end-of-life care in the context of Rawls' and Daniels' philosophy of justice. The study is based on an empirical survey of Swedish physicians who were asked whether they would want the option of physician-assisted suicide (PAS) for themselves (hereafter called own preferences), what are their attitudes towards PAS in general and whether they were prepared to prescribe PAS drugs to eligible patients. The question is to what extent the physicians' answers are impartial and consistent in a Rawlsian sense.
METHODS: The underlying indicator was the physicians' own preferences. Kappa score inter-rater agreement was measured between that response and that same physician's general attitude towards allowing PAS and preparedness to prescribe PAS drugs. The coherence of provided comments and arguments were analysed using content analysis.
RESULTS: Palliative care physicians are the least willing to offer PAS, and surgeons and psychiatrist the most willing. There is a discrepancy between physicians' general attitudes about allowing PAS, their own wishes to be offered PAS at the end of life and the concrete action of prescribing PAS drugs. Arguments given for not prescribing PAS by those in favour of PAS are seemingly but not truly inconsistent.
CONCLUSIONS: Those supporting PAS provided impartial and consistent arguments for their stances in a Rawlsian sense, while those against PAS provided partial arguments. Two specialties, psychiatrists and palliative care physicians, were coherent in their reasoning about PAS for themselves and their willingness to prescribe the needed drugs.
Systems, methods, and instrumentalities for simulating a surgical setup may be provided. In examples, a plurality of simulations of a surgical procedure may be executed. Each simulation may simulate activity in a surgical operating room with a respective one of a plurality of surgical setups. In examples, each surgical setup may comprise a respective surgical equipment setup and/or a respective surgical staff setup. A plurality of performance scores may be generated. In examples, each of the plurality of performance scores may correspond to a respective surgical setup. Each of the plurality of performance scores may be based on a performance of the respective surgical setup in simulation. A first surgical setup from the plurality of surgical setups may be determined, for example, based on the plurality of performance scores. The first surgical setup may be outputted.
The GOSH top child and adolescent health problems study aims to identify the top health concerns that parents/guardians and paediatricians in a tertiary hospital have for young people in England. The study will be surveying parents/guardians and paediatricians at Great Ormond Street Hospital (GOSH), asking them to review and give their impressions from a list of thirty common child and adolescent health issues. Analysis of responses will provide a list of problems that are most important and determine if respondents feel that the NHS England is adequately addressing these problems.

The project was designed with public partnership. The investigators conducted literature reviews, and adopted with permission, a survey instrument used by the C.S. Mott Children's Hospital National Poll in Michigan, USA. Some parents were asked to list child and adolescent health problems that they deemed most important. A consensus meeting with experts was held, to select the thirty most common and important public health issues for young people in England, from which the study will identify problems with the highest concern. This project and its intended outcomes will span medical, nursing, research and voluntary services that will improve child and adolescent healthcare provision the UK.

The State of Child Health (SoCH) Report 2017 highlights indicators of child health problems across the four nations of the United Kingdom. There are some polls that were conducted in Australia and USA, investigating the top concerns for child health problems and thus providing a framework onto which to find solutions. The Royal Children's Hospital Melbourne through its National Child Health Poll established that that excessive screen time was the greatest parental concern, and that the top ten concerns related to modern lifestyle, mental health and child safety. Similarly, the C.S. Mott Children's Hospital National Poll on children's health selected a national sample of adults to identify health topics that are a "big problem" for children and teenagers. The 2017 report identified bullying/cyberbullying as the greatest concern. However there is no available evidence about studies being conducted in the United Kingdom to find out what parents/guardians and paediatricians report as the top child and adolescent health problems.

The information would be valuable to the health professionals at the point of care, as well as the national healthcare system. This study analyses information from groups on both the supply and demand side of child and adolescent healthcare. Understanding the different perceptions of child and adolescent health problems between healthcare professionals and parents/guardians can lead to improved follow-up care and compliance with advice. Information from this study can be used as a basis for the establishment of a UK national poll that would further investigate public concerns for child health.
Transcranial direct current stimulation will be applied to study group only . Anodal transcranial stimulation will be applied on left somatosensory cortex while the cathodal one will be applied on right supra-orbital area with frequency of 2m.A for 20 minutes.Stimulation will be applied three times per week for two months.
Cardiac remodeling is a commonly observed pathophysiological phenomenon associated with the progression of heart failure in various cardiovascular disorders. Carnosol, a phenolic compound extracted from rosemary, possesses noteworthy pharmacological properties including anti-inflammatory, antioxidant, and anti-apoptotic activities. Considering the pivotal involvement of inflammation, oxidative stress, and apoptosis in cardiac remodeling, the present study aims to assess the effects of carnosol on cardiac remodeling and elucidate the underlying mechanisms. In an in vivo model, cardiac remodeling was induced by performing transverse aortic constriction (TAC) surgery on mice, while an in vitro model was established by treating neonatal rat cardiomyocytes (NRCMs) with Ang II. Our results revealed that carnosol treatment effectively ameliorated TAC-induced myocardial hypertrophy and fibrosis, thereby attenuating cardiac dysfunction in mice. Moreover, carnosol improved cardiac electrical remodeling and restored connexin 43 expression, thereby reducing the vulnerability to ventricular fibrillation (VF). Furthermore, carnosol significantly reduced Ang II-induced cardiomyocyte hypertrophy in NRCMs and alleviated the upregulation of hypertrophy and fibrosis markers. Both in vivo and in vitro models of cardiac remodeling exhibited the anti-inflammatory, anti-oxidative, and anti-apoptotic effects of carnosol. Mechanistically, these effects were mediated through the Sirt1/PI3K/AKT pathway, as the protective effects of carnosol were abrogated upon inhibition of Sirt1 or activation of the PI3K/AKT pathway. In summary, our study suggests that carnosol prevents cardiac structural and electrical remodeling by regulating the anti-inflammatory, anti-oxidative, and anti-apoptotic effects mediated by Sirt1/PI3K/AKT signaling pathways, thereby alleviating heart failure and VF.
Ionotropic glutamate receptors (iGluRs), specifically α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs), play a crucial role in orchestrating excitatory neurotransmission in the brain. AMPARs are intricate assemblies of subunits encoded by four paralogous genes: GRIA1-4. Functional studies have established that rare GRIA variants can alter AMPAR currents leading to a loss- or gain-of-function. Patients affected by rare heterozygous GRIA variants tend to have family specific variants and only few recurrent variants have been reported. We deep-phenotyped a cohort comprising eight unrelated children and adults, harboring a recurrent and well-established disease-causing GRIA1 variant (NM_001114183.1: c.1906G>A, p.(Ala636Thr)). Recurrent symptoms included motor and/or language delay, mild-severe intellectual disability, behavioral and psychiatric comorbidities, hypotonia and epilepsy. We also report challenges in social skills, autonomy, living and work situation, and occupational levels. Furthermore, we compared their clinical manifestations in relation to those documented in patients presenting with rare heterozygous variants at analogous positions within paralogous genes. This study provides unprecedented details on the neurodevelopmental outcomes, cognitive abilities, seizure profiles, and behavioral abnormalities associated with p.(Ala636Thr) refining and broadening the clinical phenotype.
Arm 1: (weekly, 28-day cycle): Approximately eighty subjects will orally self-administer eniluracil approximately 13 hr (range of 11-16 hr) before receiving 5 FU and leucovorin. The next day they will orally self-administer 5-FU and leucovorin. On the third day, they will orally self-administer leucovorin. The regimen is taken once per week for three consecutive weeks followed by one-week off-treatment.
Disclosed are artemisinin derivatives, a preparation method therefor, and the uses thereof. The structural formula of the artemisinin derivatives is represented by formula I. The compounds have suitable solubility and are relatively stable under storage conditions. A pharmacokinetic experiment shows that artemisinin can be detected in eye tissue, and is also distributed in the cornea, the conjunctiva and the aqueous humor, thereby reaching a relatively high drug concentration. As an excellent prodrug of artemisinin, the compounds represented by formula I have remarkable absorbability, and the drug concentration in the eye tissue shows that the compounds can be absorbed well. The inhibition effect on neovascularization of a burn injury model is remarkably better than that of artemisinin, thus the compounds can be used for preparing liquid preparations, such as eyedrops and injections, for use in treatment of eye tissue diseases.
Platelet-activating factor (PAF) is an important chemical mediator in the field of inflammation, but its function in the skin is unclear. To unravel the role of PAF, we focused on lysophosphatidylcholine acyltransferase 2 (LPCAT2 also called LPLAT9), a biosynthetic enzyme involved in PAF production, and investigated the role of PAF in allergic contact dermatitis (ACD) and irritant contact dermatitis (ICD). We measured the amount of PAF in the skin and investigated the ear swelling responses and leukocyte infiltration into the skin following the application of 2,4,6-trinitro-1-chlorobenzene (TNCB) or croton oil in wild-type (WT) and LPCAT2 knockout (LPCAT2-KO) mice. The amount of PAF was increased in the skin of WT mice after TNCB or croton oil application but not detected in LPCAT2-KO mice. The ear swelling response was decreased in LPCAT2-KO mice compared with that in WT mice. In the ACD model, the numbers of lymphocytes, eosinophils, macrophages, mast cells and neutrophils were smaller in LPCAT2-KO mice than in WT mice. In the ICD model, the ear swelling response was also decreased in LPCAT2-KO mice compared with that in WT mice. When double staining of each inflammatory cell type and LPCAT2 was performed in ACD tissue, marked co-staining of the eosinophil marker and LPCAT2 was observed. In addition, LPCAT2 expression was observed in the epidermis. These results indicate that PAF is involved in the infiltration of several cell types into the sites of allergic and non-allergic skin inflammation. Furthermore, eosinophils and keratinocytes are primarily responsible for PAF production in skin inflammation.
Caregivers of patients meeting eligibility criteria will be invited to participate. If they agree to participate, baseline SRBD-PSQ, OSA-18, and PedsQL questionnaires along with written informed consent forms will be mailed to them along with their standard scheduling paperwork. Caregivers will be asked to review the consent form and complete the questionnaires and bring the paperwork to clinic on the day of their visit. Sleep study testing will also be ordered prior to their visit so that it can be scheduled within a month of the initial clinic visit and again three months later.
With the expanse of technology, people are constantly exposed to an abundance of information. Of vital importance is to understand how people assess the truthfulness of such information. One indicator of perceived truthfulness seems to be whether it is repeated. That is, people tend to perceive repeated information, regardless of its veracity, as more truthful than new information, also known as the illusory truth effect. In the present study, we examined whether such effect is also observed for opinions and whether the manner in which the information is encoded influenced the illusory truth effect. Across three experiments, participants (n = 552) were presented with a list of true information, misinformation, general opinion, and/or social-political opinion statements. First, participants were either instructed to indicate whether the presented statement was a fact or opinion based on its syntax structure (Exp. 1 & 2) or assign each statement to a topic category (Exp. 3). Subsequently, participants rated the truthfulness of various new and repeated statements. Results showed that repeated information, regardless of the type of information, received higher subjective truth ratings when participants simply encoded them by assigning each statement to a topic. However, when general and social-political opinions were encoded as an opinion, we found no evidence of such effect. Moreover, we found a reversed illusory truth effect for general opinion statements when only considering information that was encoded as an opinion. These findings suggest that how information is encoded plays a crucial role in evaluating truth.
Participants in the control group will undergo Psych-Educational and BF sessions in which they will receive information about FOH and about ways of coping with FOH and BF training. More specifically, they will learn about factors associated with FOH, behavioral manifestations of FOH, negative consequences of these behavioral manifestations and about ways of coping with FOH. They will be instructed to practice BF for 15 minutes, at home for 5 initial training sessions during a week. After which they will receive another session of BF training and will be instructed to practice it at home for 10 sessions course, (5 weekly sessions for 2 weeks). Each session will be for 15 minutes.
BACKGROUND AND AIMS: Unconjugated bilirubin (UCB) is a byproduct of the heme group that indicates irregularities in the metabolism of several important biological molecules, such as hemoglobin. UCB is processed by hepatic UGT1A1, which catalyzes its conjugation to the metabolites bilirubin diglucuronide (BDG) and bilirubin monoglucuronide (BMG). The serum concentrations of BDG and BMG may indicate liver injury or dysfunction. The aim of this study was to standardize and validate a method for the identification and simultaneous quantification of BMG, BDG and UCB by LC‒MS/MS.
METHODS: Liquid‒liquid extraction allows the separation of UCB, BMG and BDG from the serum of healthy subjects or patients with liver injury. Detection and quantification were performed using an LC‒MS/MS method. Compound separation was achieved with a BEH-C18 column at 40°C. The mobile phase was prepared with 5 mM ammonium acetate (pH 6) and acetonitrile, and a flow gradient was applied.
RESULTS: This is the first study to directly quantify BMG and UCB levels in human serum; no postcalculations or correction factors are needed. However, BDG quantification requires calculations and a correction factor. We identified the molecular species with ionic transitions m/z1+ 585.4 > 299.2 for UCB, 761.3 > 475.3 for BMG, 937.3 > 299.5 for BDG and mesobilirubin 589.4 > 301.3 (IS).
CONCLUSION: The procedures used in this study allowed the simultaneous identification and quantification of the molecular species of bilirubin, BDG, BMG and UCB. Analysis of the serum levels in patients with hyperbilirubinemia revealed that patients with acute-on-chronic liver failure had elevated levels of these species.
As disclosed herein, β-arrestin1 and β-arrestin2 levels are highly elevated in brains of FTLD-tau patients suggesting that both β-arrestin1 and β-arrestin2 are elevated in the brains of patients with AD and FLTD. The current work also shows that when β-arrestin2 is overexpressed, tau levels become elevated. The data indicate that β-arrestin2 reduces tau clearance by impairing p62-mediated autophagy, a role carried out by the oligomerized form of β-arrestin2. Therefore, disclosed herein are β-arrestin oligomerization inhibitors that can be used to prevent β-arrestin oligomerization and therefore the accumulation of tau in cells, i.e. tauopathy. Also disclosed are methods of treating a tauopathy in a subject that involve administering to the subject a therapeutically effective amount of a β-arrestin oligomerization inhibitor disclosed herein.