anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To produce the titled substance useful as a preventive and remedy, on an industrial scale, by establishing a human-originated myelomonocytic cell capable of producing the titled substance, producing the titled substance using said cell and producing a monoclonal antibody using the substance as an antigen. CONSTITUTION:gamma-Interferon is produced by using a human-originated established myelomonocytic cell capable of producing gamma-interferon, e.g. HBL-38, HL-60, KG-1, etc. In the above process, the myelomonocytic cell is made to contact with an inducing agent. The myelomonocytic cell is transplanted in a body of warm-blooded animal other than human or in a diffusion chamber embedded in the body or placed outside of the body and proliferated under the supply of the body fluid of the animal. A warm-blooded animal other than human is immunized by using the obtained gamma-interferon as an antigen, an antibody- producing cell is collected from the animal and the cell is fused with a myeloma cell to produce an anti-gamma-interferon monoclonal antibody.
Constitutional trisomy 21 (T21) is a state of aneuploidy associated with high incidence of childhood acute myeloid leukemia (AML). T21-associated AML is preceded by transient abnormal myelopoiesis (TAM), which is triggered by truncating mutations in GATA1 generating a short GATA1 isoform (GATA1s). T21-associated AML emerges due to secondary mutations in hematopoietic clones bearing GATA1s. Since aneuploidy generally impairs cellular fitness, the paradoxically elevated risk of myeloid malignancy in T21 is not fully understood. We hypothesized that individuals with T21 bear inherent genome instability in hematopoietic lineages that promotes leukemogenic mutations driving the genesis of TAM and AML. We found that individuals with T21 show increased chromosomal copy number variations (CNVs) compared to euploid individuals, suggesting that genome instability could be underlying predisposition to TAM and AML. Acquisition of GATA1s enforces myeloid skewing and maintenance of the hematopoietic progenitor state independently of T21; however, GATA1s in T21 hematopoietic progenitor cells (HPCs) further augments genome instability. Increased dosage of the chromosome 21 (chr21) gene DYRK1A impairs homology-directed DNA repair as a mechanism of elevated mutagenesis. These results posit a model wherein inherent genome instability in T21 drives myeloid malignancy in concert with GATA1s mutations.
Pyrido (1,2-alpha) pyrimidine compsns. suitable for oral administration contain cpds. of formula (I): (where X = carboxy (deriv), their (quaternary) salts or their mixts; pharmaceutical supports and adjuvants; opt. other active substances and a stabilising acid which dissolves in the moisture adsorbed at the surface of the solids and is formulated at the same time as the compsn. by known methods to give a prepn. suitable for oral administration pref. as tablets, coated tablets, multilayer tablets or capsules. Used as an analgesic. Small quantities of moisture produce a reversible, tautomeric transformation converting the white crystalline (I) to a yellow tautomer which although it does not influence the activity worries patients and is preferably avoided. The present composition is more stable to this change.
Gamma delta (γδ) T cells represent a minor fraction of human T cell repertoire but play an important role in mediating anti-infectious and anti-tumorous effects in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT). We performed a prospective study to analyze the effect of different transplant modalities on immune reconstitution of γδ T cells and subsets. CD3, CD4 and CD8 T cells were analyzed in parallel. Secondly, we examined the impact of γδ T cell reconstitution on clinical outcomes including acute Graft-versus-Host-Disease (aGvHD) and viral infections. Our cohort includes 49 pediatric patients who received unmanipulated bone marrow grafts from matched unrelated (MUD) or matched related (MRD) donors. The cohort includes patients with malignant as well as non-malignant diseases. Cell counts were measured using flow cytometry at 15, 30, 60, 100, 180 and 240 days after transplantation. Cells were stained for CD3, CD4, CD8, CD45, TCRαβ, TCRγδ, TCRVδ1, TCRVδ2, HLA-DR and combinations. Patients with a MRD showed significantly higher Vδ2+ T cells than those with MUD at timepoints +30, +60, +100 (p<0.001, respectively) and +180 (p<0.01) in univariate analysis. These results remained significant in multivariate analysis. Patients recovering with a high relative abundance of total γδ T cells and Vδ2+ T cells had a significantly lower cumulative incidence of grade II-IV aGvHD after transplantation (p=0.03 and p=0.04, respectively). A high relative abundance of Vδ2+ T cells was also associated with a lower incidence of EBV infection (p=0.02). Patients with EBV infection on the other hand showed higher absolute Vδ1+ T cell counts at days +100 and +180 after transplantation (p=0.046 and 0.038, respectively) than those without EBV infection. This result remained significant in a multivariate time-averaged analysis (q<0.1). Our results suggest a protective role of γδ T cells and especially Vδ2+ T cell subset against the development of aGvHD and EBV infection after pediatric HSCT. Vδ1+ T cells might be involved in the immune response after EBV infection. Our results encourage further research on γδ T cells as prognostic markers after HSCT and as possible targets of adoptive T cell transfer strategies.
The present invention relates to the field of molecular vaccinology. Provided in the present invention is a recombinant multicomponent SARS-CoV-2 trimeric protein vaccine capable of inducing a broad-spectrum neutralizing activity. Recombinant protein ingredients include, but are not limited to, homotrimeric proteins formed by means of introducing mutation sites and trimeric auxiliary structures to the extracellular domains (ECD) of spike proteins (S proteins) of Alpha (B.1.1.7), Beta (B.1.351), Delta (B.1.617.2) and BA.1 (B.1.1.529.1). The multicomponent vaccine contains an ECD trimeric protein of the above variants, either alone or in any combination, and a pharmaceutically acceptable adjuvant. The vaccine combination shows excellent immunogenicity in mice, while also maintaining long-term humoral immunity and cellular immune responses. The multicomponent SARS-CoV-2 trimeric protein vaccine can be used for preventing infection-related diseases caused by infections with SARS-CoV-2 and variants thereof.
PURPOSE OF REVIEW: A bibliometric analysis was performed to analyze and compare the top 100 articles from the most well-known five pain journals: Pain, Pain Physician, Pain Medicine, Regional Anesthesia & Pain Medicine, and Journal of Pain. A query of the Scopus database was performed to filter the top 200 most cited articles from each journal. CY score was calculated for the top 200 articles from each journal by dividing the total number of citations by the number of years the article has been published.
RECENT FINDINGS: All articles had a collective analysis of the top CY scores, the top 100 of which were further analyzed. The pain subtype, type of publication, country of origin, and senior author were extrapolated from these top 100 articles. Frequency tables were organized, revealing Pain Journal as the highest publishing journal out of the top 100 articles. Chronic pain was the most studied subtype of pain and narrative reviews were the most common type of evidence. Studies were also organized in five-year epochs to analyze the frequency of publications in these intervals. Results show that 2010-2014 had the highest frequency of articles published overall. Journal Impact Factor (JIF) is also an objective indicator of the average number of citations per published article from each journal. The journal with the highest JIF was Pain with an impact factor of 7.926. (6).
The invention relates to an RNA interfering segment targeting to angiotensinogen in human pre-adipocytes. The sequence of the RNA interfering segment is R1: TCTGGGTGTTCCTTGGAA or R2: CTGGATGTTGCTGCTGAGA. The invention further provides an expression vector of the RNA interfering segment. The invention further provides application of inhibiting differentiation of human pre-adipocytes to mature adipocytes so as to reducing the content of adipocytes and inhibiting development of obesity. The experiments proved that the interfering plasmids designed by the invention can be used for reducing expression of angiotensinogen in HPA-v cells, the expression level of angiotensinogen mRNA is reduced by about 35% above and the expression level of the proteins is reduced by about 47.6% with various kinds of interferes. Meanwhile, the reduction of the differentiation degree of adipocytes shows that the RNAi sequence for angiotensinogen is useful to inhibit differentiation of adipocytes and development of adipocytes, reduce the content of adipocytes and inhibit development of obesity.
PROBLEM TO BE SOLVED: To obtain a compsn. which is excellent in storage stability and quickly cures at its vulcanization temp. and which gives a cured item having a hydrophilic surface, by compounding a specific polydiorganosiloxane, a specific catalyst, a specific unsatd. polysiloxane-polyether copolymer and a specific compatibilizer. SOLUTION: This compsn. contains a polydiorganosiloxane having at least two hydrosilylatable unsatd. hydrocarbon groups per molecule (e.g. α,ω- divinylpolydimethysiloxane), an effective amt. of a hydrosilylation catalyst, an unsatd. polysiloxane-polyether copolymer having 2-5 Si atoms, at least one aliph. unsaturation and at least one polyether functionality and a compmatibilizer pref. selected from among hydrocarbon polyethers or polysiloxane-polyether copolymers having solubility parameters δ of 13-17 MPa<1/2> and hydrophobic or hydrophilic fillers having surface areas of 100 m<2> /g or higher and median particle sizes of 20 nm or lower.
Over the past decade, neuroimaging tools have rapidly advanced the field of neural biomarkers of treatment response in depression. Still, despite obvious scientific progress in this field, the ability to implement neuroimaging biomarkers of antidepressant treatment response in clinical trial settings is lacking. In order to objectively assess the neural bases of treatment response in depression, the investigators will use a "Real-time Neurofeedback fMRI task", specifically designed to record and modulate mood improvement by providing neurofeedback in the context of the administration of an antidepressant treatment. In a pilot study, positive neurofeedback during the administration of the drug was associated with significant acute mood improvement and increased blood oxygen level dependent (BOLD) responses in the rostral anterior cingulate cortex (rACC), a common neural target of antidepressant treatments. The central hypothesis is that antidepressant effects in depression are mediated by increased neural activity in the rACC (AIM1), which can be used in clinical trials of antidepressant treatment to predict antidepressant effects (AIM 2) and assess the effect of antidepressant treatment on antidepressant-induced rACC neural responses (AIM 3). The results obtained from this project are expected to have an important impact on our ability to understand the cognitive and neural mechanisms implicated in antidepressant treatment responses in patients with depression, as well as on the ability to implement neuroimaging biomarkers of treatment response in the clinical trial settings.
Participants will receive HS-10386 once daily. The duration of each treatment cycle is 21 days.
The application belongs to the technical field of traditional Chinese medicine pulse feeling, and discloses a pulse force level prediction method based on CLLSR mixed models, which comprises the following steps: A1. acquiring a plurality of original pulse condition data, performing pulse force grade grading and data preprocessing on the original pulse condition data to obtain a plurality of sample data, and forming a sample set; the sample data comprise preprocessed pulse condition data and corresponding pulse force grade label values; A2. dividing a sample set into a training set and a testing set; A3. constructing CLLSR a hybrid neural network model; A4. training the CLLSR mixed neural network model by using a training set, and testing the trained CLLSR mixed neural network model by using a testing set to obtain a trained CLLSR mixed neural network model; A5. predicting pulse force level of the measured pulse condition data of the object to be detected by using the trained CLLSR hybrid neural network model; thereby, the prediction accuracy of the pulse force scoring level can be improved.
The present invention relates to a method for preparing oral liquid for nourishing yin, removing fatigue and supplementing calcium from raw material such as micron American ginseng powder, micron tortoise plastron powder, micron bee pollen and micron nacre powder processed via high-tech air flow superfine grinding, xylitol powder, a right amount of distilled water, etc. via combined processing. Because of exempt the traditional boil process, effective ingredients of the oral liquid are furthest preserved, so that the oral liquid has the obvious functions of nourishing Yin and removing fatigue and the effects of supplementing calcium, enhancing immunity, tranquilizing, improving eyesight, etc. With the oral liquid, middle-aged and old people can obtain over two hundred rich nutrient substances such as proteins, vitamins, minerals, organized enzymes, etc. Meanwhile, due to the addition of bee pollen called as a miniature nourishment treasure house accepted by oriental and western experts, the oral liquid also has the functions of beauty treatment and strengthening the body. Therefore, the oral liquid for health care, prolonging life, nourishing yin, removing fatigue and supplementing calcium is indeed designed specially for middle-aged and old people with hyperactivity of fire caused by yin deficiency.
Patients with a clinical diagnosis of upper gastrointestinal bleeding and that during endoscopy revealed to non-varicose bleeding lesions in the endoscopic treatment being necessary. The group will be submitted to injection of adrenaline at a proportion of 1: 10,000 in the four quadrants of the lesion associated with application adsorption powder, marketed under the name Hemospray. The patients will be submitted to endoscopy exam in 12 to 24 hours after the therapeutic procedure to confirm the success of the therapy and measure if there the presence of rebleeding.
After inclusion in the study, the patients are phenotyped between V1 and V4. Following this, they will be separated into 2 groups: "NaCl sensitive" patients and "non-NaCl sensitive" patients. The non-sensitive group will drop out of the study, while the others will be randomized to one of the 2 treatment arms: bottle of water or sachet of salt.
The invention discloses an anti-tumor compound DCZ0847, a preparation method and application thereof, wherein the structural formula of the compound is shown as follows. The invention also provides a preparation method of the compound, and the method has the advantages of simple steps and high yield. Cell experiments show that the compound DCZ0847 has strong killing activity on multiple myeloma, lymphoma, thyroid cancer, lung cancer, bladder cancer, gastric cancer, colon cancer cells, esophageal cancer and osteosarcoma, and can achieve the purpose of preventing and treating tumors by inhibiting the proliferation of tumor cells. DCZ0847, alone or in combination with bortezomib, was effective in inhibiting multiple myeloma cell growth in vivo. Therefore, the DCZ0847 micromolecule compound has relatively fewer side effects and has good application prospect in the field of antitumor drugs. The invention not only provides a new therapeutic drug for resisting tumors, but also provides a new way for overcoming drug resistance of tumors.
There is some clinical evidence that stimulants may lower the convulsive threshold in patients with prior history of seizures, in patients with prior EEG abnormalities in absence of seizures, and, very rarely, in patients without a history of seizures and no prior EEG evidence of seizures. In the presence of seizures, the drug should be discontinued.

Priapism

Prolonged and painful erections, sometimes requiring surgical intervention, have been reported with methylphenidate products in both pediatric and adult patients. Priapism was not reported with drug initiation but developed after some time on the drug, often subsequent to an increase in dose. Priapism has also appeared during a period of drug withdrawal (drug holidays or discontinuation): Patients who develop abnormally sustained or frequent and painful erections should seek immediate medical attention.

Peripheral Vasculopathy, Including Raynaud's phenomenon

Stimulants, including methylphenidate hydrochloride chewable tablets, used to treat ADHD are associated with peripheral vasculopathy, including Raynaud's phenomenon. Signs and symptoms are usually intermittent and mild; however, very rare sequelae include digital ulceration and/or soft tissue breakdown. Effects of peripheral vasculopathy, including Raynaud's phenomenon, were observed in post-marketing reports at different times and at therapeutic doses in all age groups throughout the course of treatment. Signs and symptoms generally improve after reduction in dose or discontinuation of drug. Careful observation for digital changes is necessary during treatment with ADHD stimulants. Further clinical evaluation (e.g., rheumatology referral) may be appropriate for certain patients.
BACKGROUND: The treatment for bilateral synchronous multiple primary lung cancers (MPLC) remains challenging. Simultaneous bilateral video-assisted thoracic surgery (VATS) may be an optimal treatment with curative intent, but its safety and feasibility are controversial.
METHODS: One hundred and fifty-eight patients who underwent simultaneous bilateral VATS (simultaneous group) and 79 who underwent two-staged bilateral VATS (two-staged group) were included in this study. Their medical records were retrospectively reviewed and analyzed.
RESULTS: The majority of patients were female and non-smokers. The most common surgical plan was lobectomy and contralateral wedge resection in both groups. There was no significant difference in the postoperative complication rate between the simultaneous groups and two-staged group (13.3% vs. 11.4%, p = 0.73). Patients who underwent simultaneous bilateral resection had shorter hospital stays, shorter anesthesia time and less chest drainage compared with those who underwent two-staged resection. Advanced TNM stage, complicated surgical plan and aggressive lymph node resection were risk factors for postoperative complications in simultaneous bilateral VATS. Patients in two groups had similar overall survival and disease free survival (p = 0.2).
CONCLUSIONS: Simultaneous bilateral VATS for bilateral lung nodule resection is as safe and feasible as two-staged bilateral VATS. Patients who underwent simultaneous bilateral resection had similar or even better outcomes compared to that of the two-staged group. Simultaneous bilateral VATS is potentially an optimal treatment option for patients with erarly cTNM stage and good physical condition.
INTRODUCTION: The present study investigated the role of long non-coding RNA (lncRNA) GABPB1-IT1 in ischemia-induced acute kidney injury (AKI).
METHODS: The expression of GABPB1-IT1 in the plasma of patients with ischemia-induced AKI and healthy controls was detected by RT-qPCR. GABPB1-IT1 and miR-204-5p were overexpressed in human renal proximal tubular epithelial cells (HRPTEpCs), followed by RT-qPCR to assess the overexpression effect and the regulatory relationship between GABPB1-IT1 and miR-204-5p. Methylation-specific PCR was performed to assess the promoter methylation status of miR-204-5p. Additionally, a cell apoptosis assay was carried out to evaluate the correlation between miR-204-5p and GABPB1-IT1 in the context of hypoxia-induced apoptosis of HRPTEpCs.
RESULTS: GABPB1-IT1 was upregulated in the plasma of patients with ischemia-induced AKI. In HRPTEpCs, hypoxia upregulated the expression of GABPB1-IT1. MiR-204-5p was downregulated in ischemia-induced AKI, and the expression of miR-204-5p was inversely correlated with GABPB1-IT1. In HRPTEpCs, overexpression of GABPB1-IT1 decreased the expression levels of miR-204-5p and increased miR-204-5p gene methylation. In addition, overexpression of GABPB1-IT1 reduced the inhibitory effects of miR-204-5p on the apoptosis of HRPTEpC induced by hypoxia. Furthermore, overexpression of GABPB1-IT1 promoted kidney injury, renal tissue injury scores, and the level of serum creatinine. However, miR-204-5p had the opposite effect.
CONCLUSION: GABPB1-IT1 was upregulated in ischemia-induced AKI and may induce hypoxia-induced apoptosis of HRPTEpC by methylation of miR-204-5p.
BACKGROUND AND PURPOSE: Intraplaque neovessels (INVs) are considered important contributors to carotid plaque vulnerability. The purpose of this study was to examine whether differences in INV distribution affect plaque vulnerability.
METHODS: The study cohort comprised 110 patients with significant stenosis of the carotid artery who had undergone carotid endarterectomy. The distribution of INVs within carotid plaques was assessed by immunohistochemical studies using anti-CD-34 antibody as a marker for endothelial cells. First, we divided the patients into M group and S group depending on the numbers of INVs in middle and shoulder region. Next, we categorized carotid plaques into four categories according to the distributions of INVs: Shoulder, Middle, Mixed, and Scarce. We then compared total area of intraplaque hemorrhage, cholesterol, and calcification, width of thinnest fibrous cap, and number of INVs between the four categories of plaque.
RESULTS: The area of intraplaque hemorrhage was significantly larger in the M group than in the S group (P = 0.011). Meanwhile, symptomatic carotid stenosis was significantly more frequently associated with the Middle and Mixed than the Shoulder and Scarce categories (P < 0.01). The area of intraplaque hemorrhage was significantly different between the four groups (P = 0.022). Rupture of the fibrous cap was more frequently detected in the Middle and Mixed than the other categories (P = 0.002).
CONCLUSIONS: INVs in the middle region of carotid plaques are strongly associated with symptomatic carotid stenosis, intraplaque hemorrhage, and rupture of the fibrous cap. Our findings indicate that the distribution of INVs may affect plaque vulnerability.
Participants in the control group were treated to reduce limitations at body function and activity levels, while treatment for balance disorders was restricted to a maximum of 10' per session. Treatment mainly focused on increasing range of joints motion, reducing of muscle contractures and strength training.