anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The Microtable® Microstereotactic Frame and Drill Press and Associated Method for Cochlear Implantation consists of a patient-customized microstereotactic frame which targets the cochlea. The intended use of the device in this early feasibility study is to surgically access the cochlea, allowing placement of an intra-cochlear electrode array for cochlear implantation, thereby providing a less invasive surgical option than currently performed. Compared to traditional cochlear implantation (CI) surgery, the investigators hypothesize that the minimally invasive, image-guided approach may offer the following benefits: (1) shorter procedure time including shorter general anesthesia time, (2) less tissue removal potentially eliminating post-operative mastoid bone depression, decreased post-operative patient discomfort, and quicker wound healing, (3) better chance of preservation of taste secondary to preservation of the chorda tympani nerve, and (4) standardization of electrode placement potentially allowing more consistent placement within the scala tympani sub-compartment of the cochlea which has been shown to be associated with improved post-operative audiological performance. This early feasibility study will focus on the advantages of the new technology to the patient. Advantages to the healthcare delivery system will be examined during the pivotal study phase.

The investigators propose this early feasibility study to determine if minimally invasive image-guided drilling to surgically access the cochlea for CI can be successfully performed. The study will involve only unilateral CI. The decision of unilateral vs. bilateral implantation is made clinically and before the patient may elect to enroll in this study. Bilateral implantation can take place either simultaneously or sequentially, with the decision made by the clinician as part of standard care.

If a participant is scheduled for routine bilateral CI, the traditional approach will be used on one side and the investigational approach on the other. Traditional surgery will be performed on the better-hearing ear, and the investigational technique will be performed on the poorer hearing ear. To minimize patient variability, the investigators will only be studying lateral wall electrodes, the Cochlear slim straight electrode and MED-EL electrodes. The investigators plan to enroll 12 cochlear implant patients in two groups. Group 1 will consist of patients implanted under direct visualization afforded by lifting a tympanomeatal flap, and Group 2 will consist of patients implanted with visualization afforded by passing an endoscope across the eardrum via a myringotomy.
Subjects randomized to mailed nicotine replacement therapy will be offered a 2 week supply of nicotine replacement therapy mailed to their home address. Daily smokers planning to quit in the next 30 days will be offered nicotine patches (14 or 21 mg patches) and lozenges (2 or 4 mg lozenges) dosed according to package instructions. Non-daily smokers planning to quit will be offered a 2 week allotment of 2 mg lozenges alone. Smokers not planning to quit will be offered one box of lozenges (72 count box of 4 mg or 2 mg lozenges based on time to first cigarette as above per package instructions) to use when they are not smoking during their practice quit attempt.
Chronic HCV infection has relatively slow rate of progression. Liver fibrosis is the main sequlae and usually progressed to cirrhosis after long period (10 to 20 years) \[6\]. Once cirrhosis is established the disease progression remains unpredictable: cirrhosis can remain indolent for many years in some patients whilst progressing in others to HCC, hepatic decompensation and death. Overall once cirrhosis has developed there is a 1-5% annual risk of HCC and a 3-6% annual risk of hepatic decompensation. Following an episode of decompensation the risk of death in the following year is between 15% and 20% Treatment of chronic HCV has been dramatically changed in the last few years with introduction of direct acting antivirals (DAAs). The new therapies with excellent safety profiles, shorter duration of therapy and marked higher efficacy can be even used in patients with advanced fibrosis and cirrhosis
Participants will receive a loading series of Crovalimab comprised of an intravenous (IV) loading dose on Day 1, followed by weekly Crovalimab subcutaneous (SC) doses for 4 weeks on Week 1 Day 2, then on Weeks 2, 3 and 4. Maintenance SC dosing will begin at Week 5 and will continue every 4 weeks (Q4W) thereafter for a total of 48 weeks of treatment.
The invention relates to a recombinant protein capable of recruiting dendritic cells and application thereof in immunotherapy, belonging to the technical field of biomedicine. The invention discloses a recombinant protein capable of recruiting dendritic cells, the amino acid sequence of which comprises SEQ ID NO: 1. SEQ ID NO: 2. SEQ ID NO: 3. SEQ ID NO: 4. SEQ ID NO:5 or SEQ ID NO:6, the recombinant protein contains high proportion of glycine or serine, can promote chemotaxis and migration of Dendritic Cells (DC), is a safe and nontoxic natural component, and has good application prospect in the aspect of immunoregulation.
Included patients with clinically suspected acute myocarditis (n=30-40) will undergo a 68Ga-DOTA-TOC PET/CT and a blood sample will be taken. Furthermore, participants will undergo a contrast-enhanced MRI and endomyocardial biopsy (if clinically indicated) as part of the clinical routine work-up.
Expeller soybean (ESB) is a widely used protein source in broiler diets due to its high amino acid digestibility. However, improper heat processing of ESB can negatively affect nutrient digestion, absorption, and metabolism leading to decreased growth performance. The study aimed to investigate the impact of varying processing temperatures on growth performance, amino acid digestibility (AID), and intestinal integrity using 3 different commercial batches of ESB processed at distinct temperatures. These temperatures were 182°C (normal-control), 199°C (overcooked), and 154°C (undercooked). 1,860 off-sex male Cobb 500 broilers were allocated randomly to these treatments, with 10 replicate floor pens (62 birds/pen) from 1 to 35 d of age. Birds consuming the overcooked ESB exhibited significantly lower body weight gain (BWG) and feed intake (FI) on d 14, 28, and 35. They also showed higher feed conversion ratio (FCR) and smaller relative right pectoralis major (RPM) weights at d 35. Meanwhile, birds fed undercooked ESB demonstrated reduced BWG at d 14. Serum fluorescein isothiocyanate-dextran (FITC-d; 4 kD) concentrations on d 16 were notably elevated in birds fed overcooked ESB, indicating increased gut permeability. Overcooked ESB reduced the AID coefficients of several amino acids on d 14 and 28, with Lys experiencing the highest reduction (8%). Undercooked ESB, however, mainly affected the AID of Val, and Phe at d 28. In conclusion, overcooked ESB decreased amino acid digestibility, impaired gut barrier function, and led to diminished growth performance. Conversely, undercooked ESB primarily affected the digestibility of Val and Phe and resulted in reduced BWG at d 14. These findings underscore the critical role of proper heat processing in preserving the nutritional quality of ESB in broiler diets, influencing optimal growth performance, and maintaining intestinal health.
Background: Previous research has indicated that continuous exposure to disaster-related information through social media can lead to vicarious trauma. However, scholars have recognized the need for further in-depth research into the underlying mechanisms influencing this relationship.Objective: The purpose of this study is to investigate the impact mechanism of social media usage on vicarious traumatization in users and analyze the roles of recommendation systems and peer communication.Methods: This study was conducted with college students in China, focusing on the context of the MU5735 aircraft flight accident in China in which 123 passengers and 9 crew members died. Data were collected through an online questionnaire. The partial least square structural equation modelling (PLS-SEM) method was used to test the data and model.Results: This study obtained valid responses from 1317 participants. The study findings revealed a significant positive correlation between social media usage(β = 0.180,P < .001), recommendation systems usage (β = 0.172, P < .001), peer communication (β = 0.303, P < .001), and the development of vicarious traumatization. Recommendation systems usage (specific indirect effect  = 0.063, P < .001) and peer communication (specific indirect effect  = 0.138, P < .001) mediated the relationship between social media use and vicarious trauma. Additionally, the impact of peer communication on vicarious trauma was found to be higher compared to the effects of continuous social media use and recommendation system use.Conclusion: The study found that the use of social media to obtain information about accidents, the frequent pushing of accident information by recommender systems, and the frequent discussion of accidents among peers during unexpected accidents contribute to vicarious traumatization. The study suggests that users' reduced retrieval of accident information via social media, as well as reduced peer-to-peer discussions about accidents, and social media platforms' adjustment of recommender system algorithm rules to reduce accident information pushes, may help reduce the likelihood of users experiencing vicarious traumatization.
1,263,480. Injectable adjuvants. HAVERLOCKHART LABORATORIES Inc. 17 Feb., 1969 [23 Feb., 1968], No. 8408/69. Heading A5B. An injectable, non-toxic medicinal adjuvant for use with a medicinal agent containing nitrogen atoms comprises a synthetic polymer having free hydroxyl and carboxyl sites and an emulsifier for the polymer admixed therewith, the polymer and the emulsifier, in combination, being capable of undergoing sustained release but substantially complete dissociation and absorption in the tissue of a host. The polymer is suitably a cross-linked polymer of acrylic acid, preferably cross-linked with a polysaccharide such as polyallyl sucrose. The adjuvant may also contain a compound containing amino groups which are reactable with any free hydroxyl and carboxyl sites which have not reacted with the nitrogen atoms of the medicinal agent. Suitable compounds containing amino groups include collagen, preferably reconstituted; basic amino acids; epinephrine or other catecholamines; peptides; synthetic amines or polyamines; antigens such as those consisting of proteins or mucopolysaccharides; natural non- antigenic proteins such as actomysin or peptide antibiotics. In examples, antigenic compositions prepared from Clostridium chauvoei septicum, Clostridium perfringens, Leptospira icterohemorrhagiae and canicola and Erysipelas as well as a bivalent encephalomyelitis vaccine, are referred to.
Patients in the control group were infused intravenously with ringer lactate solution (400 ml/h) in the PACU. The study outcomes were collected at three assessment periods, 0-0.5 h, 0.5-6 h, 6-24 h, after anesthesia by an independent investigator.
BACKGROUND: Sexually transmitted infections (STI) are a global concern. In Italy, despite the presence of publicly funded STI diagnostic centers, limited attention has been given to the knowledge of these services among the adult population. This study primarily aimed to evaluate Italian adults' knowledge about STI and dedicated health care centers. Secondarily, it explored condom usage behaviors.
METHODS: Conducted nationwide, this cross-sectional study used an online questionnaire. The primary outcomes included knowledge of dedicated STI centers and scores on the Sexually Transmitted Disease Knowledge Questionnaire (STD-KQ); secondary outcomes included inconsistent condom usage rates during various forms of intercourse.
RESULTS: With a participant count of 1036, results indicated that only 36% were aware of dedicated STI centers. The median STD-KQ score was 11 (interquartile range, 6-15). Multivariable regression models unveiled factors significantly associated with knowledge. Lesbian, gay, bisexual, transsexual, and queer (LGBTQ) individuals, health care workers, and those with higher STD-KQ scores exhibited greater STI centers' awareness. Better STD-KQ scores correlated with higher education levels, substance use, past STI diagnosis, and health care employment. Around 80% of the sample reported inconsistent condom use during different forms of intercourse. Although enhanced knowledge correlated with increased condom use, certain groups exhibited discrepancies between knowledge of STI and actual condom use.
CONCLUSIONS: These findings emphasize the need for targeted awareness campaigns to enhance accessibility to STI centers, underscoring the necessity for multifaceted interventions beyond information dissemination to address suboptimal condom usage. In providing insights into STI knowledge and behaviors among Italian adults, this research informs interventions and policy adjustments to combat STI.
Arterial ischemic stroke (AIS) affects about 2 children per 100,000 per year and is one of the top 10 causes of mortality in children. After stroke, there is a disturbance in cerebral blood flow (CBF) autoregulation, and changes in head position may change CBF. Currently, practice at the Children's Hospital of Philadelphia (CHOP) is to keep the head of bed (HOB) of a child with AIS flat for 24 hours; however, there is no evidence that this practice is efficacious in children. Furthermore, maintaining a child supine for 24 hours is uncomfortable for the child and is often unenforceable in younger children. This study will use a noninvasive optical technique to measure CBF as HOB position is changed to assess the effectiveness of head of bed position in increasing CBF in children with acute arterial ischemic stroke.

The primary objectives are to determine the difference in CBF at HOB flat (0 degrees) and HOB at +30 degrees in healthy children and in children with AIS. The secondary objectives are to examine CBF in healthy children and in children with AIS at other HOB angles (0, +15, and +30 degrees) compared to the CBF at HOB 0 degrees and to determine if the position that maximizes CBF varies over time from stroke onset.
The ovarian stimulation in this group will be started with recombinant Follicle-Stimulating Hormone (r-FSH) or r-FSH + human Menopausal Gonadotropin (hMG) on the third day of the menstrual cycle and the dose will be adjusted according to the ovarian response. Initiation of 0.25 mg of GnRH antagonist; Cetrorelix; will take place after detecting a leading follicle diameter ≥ 14 mm. GnRH antagonist administration will be continued till the day of ovulation triggering, which will be accomplished by given 10,000 IU of human Chorionic Gonadotropin (hCG) when at least three follicles become more than 16-17 mm. After 35±2 hours of ovulation triggering, the oocytes will be retrieved by transvaginal ultrasound-guided follicle aspiration. Then they will be prepared to undergo an Intracytoplasmic Sperm Injection (ICSI).
<P>PROBLEM TO BE SOLVED: To provide a medicament for and a method for promoting replication of hepatocytes, and also to provide a medicament for and a method for improving insulin resistance.  <P>SOLUTION: The effective amount of a neutralizing agent for CXCL 10 belonging to a sub-family of chemokines which are heparin-binding proteins is administered to the hepatocytes to promote the replication of the hepatocytes. A factor which is specifically bound to CXCL 10 to suppress the activity of CXCL 10 or that which suppresses CXCL 10 expression is suitably used as the above neutralizing agent. It is possible to restore and regenerate impaired hepatic tissue by administering the neutralizing agent thereto. Besides, by administering the effective amount of the neutralizing agent for CXCL 10 to the hepatocytes, the insulin resistance in type II diabetes, metabolic syndrome or the like is improved.  <P>COPYRIGHT: (C)2008,JPO&INPIT
FIELD: pharmacy. SUBSTANCE: method involves filtration of pantocrin concentrate on Buchner funnel charged with solid, narrow-porous, slowly filtering paper for thin deposits, addition of acidin (4-9 vol.%) to the obtained filtrate, dilution of mixture with distilled water (1:100), treatment of solution with activated carbon for 30 min followed by filtration. Then under aseptic conditions sterilizing filtration and preparation ampoule were carried out. Storage time for pantocrin for injection is prolonged up to 5 years at the retained biological activity of pantocrin. EFFECT: improved method of preparing, prolonged storage. 3 tbl
PROBLEM TO BE SOLVED: To obtain a composition capable of being used in a low concentration, capable of minimizing side effects, and used for protecting a skin, a hair and a mucosa from oxidation stress by using a dehydroalanine, a part of which is new, as an active ingredient. SOLUTION: This composition contains a dehydroalanine of formula I  R1 is H or a 1-4C alkyl; R2 is formulas II (X1 to X5 are each H, a halogen, OH, an alkyl, etc.) or III [(n) is 2-4], and an alkali metal, an alkaline earth metal or an ammonium salt thereof and is used for a perfumery treatment to prevent a skin, a hair and a mucosa from oxidation stress. The compound of formula I manifests the activities in a low concentration such as 0.001-10 wt.%, preferably 0.01-2 wt.%. The compound of formula I is exemplified by N- benzoyldehydroalanine and N-(o-toluyl)dehydroalanine. Compounds of formulas IV [R1 is H; X is a halogen; R is an alkyl residue; (n)+(M)=1-5; (p) is 0 or 1] and V [(n) is 2-4, R1 is H or an alkyl] are new.
A traditional Chinese medicine for treating phlegm-dampness type tympanitis is disclosed. Phlegm-dampness type tympanitis is usually caused by factors such as vasospasm, infection caused by water entering ears during swimming and the like, is accompanied with symptoms such as swelling pain and blocking in ears, dizziness, tiredness and hypodynamia, hearing loss and the like, and affects the normal work and life of people. At present, there are many methods for treating tympanitis, but those methods are generally high-cost. In order to solve the above problems, the invention provides a traditional Chinese medicine for treating the phlegm-dampness type tympanitis. The traditional Chinese medicine has effects of invigorating spleen, diminishing inflammation, unblocking stuffy orifice, removing dampness and the like. The traditional Chinese medicine is prepared from pure traditional Chinese medicines. The specific formula of the traditional Chinese medicine of the invention comprises root of kudzu vine, Radix Astragali, Chinese angelica, lily magnolia, akebia stem, oriental waterplantain rhizome, grass-leaved sweetflag rhizome, Plantain seed and dried orange peel.
The treatment will consist of 10-15 g/day of hGOS, which will be provided to participants as a powder that can be added to any non-alcoholic beverage. The intervention will last for 4 weeks since the research team has shown in adult individuals that a 4-wk period allows for the observation of changes to the gut microbiome. The study will end after the second time-point sample collection at 4 weeks.
Patients participate in a memory and thinking skills workshop once weekly for 7 weeks. Patients complete cognitive tests and questionnaires at pre-baseline (Visit 1), baseline (Visit 2), and 7 weeks (Visit 3).
The short film training video will be prepared by researchers based on literature and appropriate for the level of children aged 7-12. The content will include topics such as preparation for KİAB, KİAB environment and the process after KİAB. Since the short film will be shot in a realistic manner, the scenario will include a doctor, a nurse, a child patient and a parent. The short film will be shot in the clinic where the data will be collected, at the appropriate time for the clinic. After the short film is shot, the editing process will be done and the final version will be given.
The audio-visual assisted Flipped Classroom (FC) CAPD Training Programme is a one-week individual intervention, which consists of five sessions (8-hours each). Pre-class audio-visual tutorials will be provided for self-study prior to F2F sessions. Six instructional videos, each dedicated to a specific procedure, are accessible for preview and repeated viewing as needed. Such flexibility allows the patients to revise at their own preferred time and pace. The four videos are (1) CAPD preparation and hand washing, (2) CAPD bag exchange procedure (Ultrabag or Balance systems), (3) Trouble shooting, and (4) Addressing contamination, (5) Detecting peritonitis, and (6) Exit site care. Participants will be asked to take note of any issues or difficulties they encounter while watching the video. A CAPD education booklet will be prepared and distributed to the patients at the beginning of the F2F training session. Take-home exercises will allow participants to revise the materials covered.
Participants in this study are will receive the PRR intervention. Participants will have two phases of intervention. In the three-month Training phase, participants will be assigned to 20, biweekly (90-minute) lessons over 12 weeks. In the nine-month Maintenance phase, participants will attend weekly lessons at least 3 times per month.
Participants with lower risk MDS patients who have symptomatic anemia that are transfusion independent (TI). Participants will be asked to come to the study clinic weekly for the first 3 weeks and then 1 time every 3 weeks after that to have tests and procedures (such as physical exams and blood draws). Luspatercept will be administered once every 3 weeks.
OBJECTIVES: The objective of the present study was to model the effects of a reduced number of treatment centres for acute type A aortic dissection on preclinical transportation distance and time. We examined whether treatment in selected centres in Germany would be implementable with respect to time to treatment.
METHODS: For our transportation model, the number of aortic dissections and respective mean annual volume were collected from the annual quality reports (2015-2017) of all German cardiac surgery centres (n = 76). For each German postal code, the fastest and shortest routes to the nearest centre were calculated using Google Maps. Furthermore, we analysed data from the German Federal Statistical Office from January 2005 to December 2015 to identify all surgically treated patients with acute type A aortic dissection (n = 14 102) and examined the relationship between in-hospital mortality and mean annual volume of medical centres.
RESULTS: Our simulation showed a median transportation distance of 27.13 km and transportation time of 35.78 min for 76 centres. Doubling the transportation time (70 min) would allow providing appropriate care with only 12 medical centres. Therefore, a mean annual volume of >25 should be obtained. High mean annual volume was associated with significantly lower in-hospital mortality rates (P < 0.001). A significantly lower mortality rate of 14% was observed (P < 0.001) if a mean annual volume of 30 was achieved.
CONCLUSIONS: Operationalizing the volume-outcome relationship with fewer but larger medical centres results in lower mortality, which outweighs the disadvantage of longer transportation time.