anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain a hair tonic exhibiting remarkable hair growth promoting effect and excellent in hair rearing effect and effects of prevention of alopecia and prevention of dander. CONSTITUTION:This hair tonic is obtained by blending (A) at least one kind of substance having hair growth effect with (B) a sesquiterpene-based compound having percutaneous absorption promoting effect in open system, e.g. a hydrocarbon such as bisabolene or zingiberene, an alcohol such as bisabolol or farnesol, ketones such as methyl ionone and methyl santalate, ketones such as methyl ionone or esters such as methyl santalate. The component B is preferably blended in an amount of 0.01-20wt.% based on weight of final composition. As the component A, glycyrrhizic acid and glycyrrhetic acid and their derivatives, amino acid or its derivative (e.g. L-methione or L-serine), female sex hormone (e.g. estradiol), anti-inflammatory agent (e.g. hydrocortisone), ingredient having blood circulation promoting action and/or hair matrix cell potentiating action (e.g. extract of Swertia jaonica Makino), vitamin B6 and its derivative, germicide, an keratolytic agent, an extract of galenical medicine, etc., is exemplified.
Provided is a composition comprising plant extract, especially an extract of Brassica campestris subsp. napus var. nippo-oleifera., which shows excellent skin elasticity improving effect, has collagen biosynthesis effect without causing any toxicity or irritation during the human safety test so as to be usefully used for improving skin wrinkle. The cosmetic composition for improving skin wrinkle comprises an extract of Brassica campestris subsp. napus var. nippo-oleifera. In the composition, the extract is an ethanol extract of Brassica campestris subsp. napus var. nippo-oleifera and the dried content thereof regarding the total weight of the composition is 0.0001-10.0 wt.%. The cosmetic composition is in the form of nutritive cream, astringent, skin, essence, nutritive gel or massage cream.
OBJECTIVES: To explore the optimal laser settings and treatment strategies for thulium fibre laser (TFL) lithotripsy, namely, those with the highest treatment efficiency, lowest thermal injury risk, and shortest procedure time.
MATERIALS AND METHODS: An in vitro kidney model was used to assess the efficacy of TFL lithotripsy in the upper calyx. Stone ablation experiments were performed on BegoStone phantoms at different combinations of pulse energy (EP ) and frequency (F) to determine the optimal settings. Temperature changes and thermal injury risks were monitored using embedded thermocouples. Experiments were also performed on calcium oxalate monohydrate (COM) stones to validate the optimal settings.
RESULTS: High EP /low F settings demonstrated superior treatment efficiency compared to low EP /high F settings using the same power. Specifically, 0.8 J/12 Hz was the optimal setting, resulting in a twofold increase in treatment efficiency, a 39% reduction in energy expenditure per unit of ablated stone mass, a 35% reduction in residual fragments, and a 36% reduction in total procedure time compared to the 0.2 J/50 Hz setting for COM stones. Thermal injury risk assessment indicated that 10 W power settings with high EP /low F combinations remained below the threshold for tissue injury, while higher power settings (>10 W) consistently exceeded the safety threshold.
CONCLUSIONS: Our findings suggest that high EP /low F settings, such as 0.8 J/12 Hz, are optimal for TFL lithotripsy in the treatment of COM stones. These settings demonstrated significantly improved treatment efficiency with reduced residual fragments compared to conventional settings while keeping the thermal dose below the injury threshold. This study highlights the importance of using the high EP /low F combination with low power settings, which maximizes treatment efficiency and minimizes potential thermal injury. Further studies are warranted to determine the optimal settings for TFL for treating kidney stones with different compositions.
PURPOSE: Cancer cachexia leads to poor outcomes, especially for patients with advanced stage disease. The cachexia index (CXI), a novel biomarker for cancer cachexia, has been identified as a prognostic indicator for several malignancies. The present study aimed to clarify the prognostic significance of the CXI for patients with recurrent pancreatic cancer.
METHODS: This retrospective study enrolled 113 patients diagnosed with recurrence following pancreatectomy for pancreatic cancer, to analyze the association between the CXI and prognostic survival.
RESULTS: The 2-year overall survival rate and median survival of all patients were 28.5% and 12.6 months, respectively. The 2-year overall survival curve in the high CXI group was significantly better than that in the low CXI group (p < 0.001). The rate of chemotherapy after recurrence was significantly lower in the low CXI group than in the high CXI group (p = 0.002). Multivariate analysis identified the CXI as an independent prognostic factor for patients with recurrent pancreatic cancer (p = 0.011).
CONCLUSIONS: The CXI proved useful for predicting the post-recurrence prognosis of patients with recurrent pancreatic cancer. Patients with a low CXI at the time of recurrence have poorer prognostic outcomes than those with a high CXI.
Prior to first use, VICTOZA should be stored in a refrigerator between 36ºF to 46ºF (2ºC to 8ºC). Do not store in the freezer or directly adjacent to the refrigerator cooling element. Do not freeze VICTOZA and do not use VICTOZA if it has been frozen.

After first use of the VICTOZA pen, the pen can be stored for 30 days at controlled room temperature (59°F to 86°F; 15°C to 30°C) or in a refrigerator (36°F to 46°F; 2°C to 8°C). Keep the pen cap on when not in use. Protect VICTOZA from excessive heat and sunlight. Always remove and safely discard the needle after each injection and store the VICTOZA pen without an injection needle attached. This will reduce the potential for contamination, infection, and leakage while also ensuring dosing accuracy. Always use a new needle for each injection to prevent contamination.
FIELD: food industry.SUBSTANCE: proposed is the use of dairy product, fermented by bacteria producing lactic acid, and comprising lactic acid and/or lactate, to obtain a nutritional composition for preventing anemia and/or the iron deficiency, for increasing iron absorption, increasing iron bioaccessibility and/or increasing iron bioavailability in a human subject, as well as for improving cognitive development, improving motor development and/or improving socio-emotional development in a human subject with an age of 0 to 36 months, suffering from iron deficiency or anemia for preventing cognitive disorders, motor disorders and/or socio-emotional disorders in a human subject with an age of 0 to 36 months, suffering from iron deficiency or anemia. Wherein the nutritional composition further comprises i) at least 6 g lactose per 100 ml nutritional composition or at least 40 wt. % lactose based on dry weight of the nutritional composition, and ii) iron. Wherein the nutritional composition comprises protein in an amount of 1.25 to 4 g per 100 kcal, lipid in an amount of 3 to 7 g per 100 kcal of the composition and the digestible carbohydrate comprising said lactose provided in an amount of 5 to 20 g per 100 kcal of the composition. Composition also comprises iron in a concentration of 0.4 to 1.4 mg per 100 ml of the nutritional composition or 0.03 to 0.065 mg per g based on dry weight of the nutritional composition. At least 90 wt. % of the sum of lactic acid and lactate is in the form of L-isomer in the composition. Nutritive composition is also proposed.EFFECT: group of inventions provides increased iron bioavailability.30 cl, 1 tbl, 2 ex
The goal of the proposed research is to gather information from Jewish Vocational Service consumers and employees about the association between social anxiety disorder and unemployment. A recent nationally representative epidemiological study places the lifetime prevalence of DSM-IV SocAD at 12.1% (Kessler et al., 2005). Social anxiety disorder is associated with notable impairments in social functioning (Kessler, 2003; Stein and Kean, 2000). A large majority of people with social anxiety disorder report significant impairment in occupational functioning (Stein, et al., 2000; Turner et al., 1986). Specific impairments include turning down job offers and promotions (Stein, Torgrud, \& Walker, 2000), reduced productivity and job performance (Wittchen, et al., 2000), lowered educational attainment \& early school dropout (Stein \& Kean, 2000), increased unemployment (Heimberg et al.,1990a), financial dependence (Scheier et al, 1992), and reduced income (Magee et al., 1996). Social anxiety disorder likely interferes with job attainment due to job interview avoidance, excessive anxious arousal during job interviews, and limited social networks to provide job leads. Our longitudinal study of mothers receiving welfare found that the diagnosis of social anxiety disorder was the strongest psychiatric predictor of reliance on welfare for support over time. We have also completed a study that identifies social anxiety disorder as the only psychiatric disorder that significantly interferes with attaining work among individuals who participated in an internationally tested, best-practice, vocational services intervention program. We have begun to screen individuals for the presence of social anxiety at Jewish Vocational Service in Detroit, Michigan, where the primary clientele are economically disadvantaged, African Americans who are seeking work. Our screening efforts confirm the association between suspected social anxiety disorder and unemployment in this population. This project will build upon these findings and will interview JVS consumers and employees to gain more insight and knowledge into the relationship between social anxiety disorder and unemployment. It will also inform future research on the design and development of a culturally appropriate, vocationally focused, sustainable, cognitive-behavioral intervention for unemployed, economically disadvantaged, urban-dwelling persons whose job attainment efforts have been undermined by the presence of social anxiety disorder.
The invention relates to medicine, in particular to a process for the preparation of the drug of sedative and spasmolytic action. The process consists in that a complex of solution of -bromomethyl butanoic acid ether and peppermint oil is prepared. Thereafter - cyclodextrin is wetted with purified water and then with solution of -bromomethyl butanoic acid ether and peppermint oil. The wet complex prepared is unloaded and dried on stands for 2-2.5 days with control of weight loss when drying. After drying the complex is comminuted in mixer and drying is completed for not less than 12 hours. Thereafter the complex is sized by means of turbo calibrator. Simultaneously additives such as excipients, detachers, lubricants, flavors are prepared. The complex prepared is loaded to the bin with Phenobarbital, excipients, detachers, lubricants, flavors, and mass is mixed in blender. The mass obtained is sized and mixed in the blender for 30-40 min. The final mix is transferred to the form of a single dosage.
Infants at risk of HIE require early identification and initiation of therapeutic hypothermia (TH). Earlier treatment with TH is associated with better outcomes. aEEG is frequently used when making the decision whether to commence TH. As this is often limited to tertiary centers, TH may be delayed if the infant requires transport to a center that provides it. We aimed to provide a method for the application of amplitude-integrated electroencephalogram (aEEG) and to determine the feasibility of acquiring clinically meaningful information during transport. All infants ≥35 weeks, at risk of HIE at referral, were eligible for inclusion. Scalp electrodes were placed in the C3-C4; P3-P4 position on the infant's scalp and connected to the aEEG amplifier. The aEEG amplifier was, in turn, connected to a clinical tablet computer with EEG software to collect and analyze aEEG information. Recordings were reviewed by the chief principal investigator and two independent reviewers (blinded) for background trace and artifact. Predefined criteria for data quality were set to movement artifacts and software impedance notifications. Surveys were completed by healthcare staff and parents for acceptability and ease of use.
Placebo will be 10mL of normal saline in the syringe. Administered twice via intravenous administration; the first dose 10 minutes prior to the dressing change and a second dose 20-30 minutes into the dressing change procedure. The study will provide study drug for up to five dressing change procedures (i.e. ten total doses).
Adipose tissue is composed of adipocytes, stromal vascular fraction, nerves, surrounding immune cells, and the extracellular matrix. Under various physiological or pathological conditions, adipose tissue shifts cellular composition, lipid storage, and organelle dynamics to respond to the stress; this remodeling is called "adipose tissue plasticity". Adipose tissue plasticity includes changes in the size, species, number, lipid storage capacity, and differentiation function of adipocytes, as well as alterations in the distribution and cellular composition of adipose tissue. This plasticity has a major role in growth, obesity, organismal protection, and internal environmental homeostasis. Moreover, certain thresholds exist for this plasticity with significant individualized differences. Here, we comprehensively elaborate on the specific connotation of adipose tissue plasticity and the relationship between this plasticity and the development of many diseases. Meanwhile, we summarize possible strategies for treating obesity in response to adipose tissue plasticity, intending to provide new insights into the dynamic changes in adipose tissue and contribute new ideas to relevant clinical problems.
N-Nitroso compounds (NOCs) are recognized as important factors that promote gastric cancer development, but the specific effects and potential mechanisms by which NOC exposure promotes gastric cancer are still poorly understood. In this study, we explored the effects and potential molecular mechanisms of NOCs on the promotion of gastric cancer using methylnitronitrosoguanidine (MNNG), a classical direct carcinogen of NOC. The results of in vivo and in vitro experiments showed that chronic and low-concentration MNNG exposure significantly promoted the malignant progression of tumors, including cell migration, cell invasion, vasculogenic mimicry (VM) formation, cell spheroid formation, stem cell-like marker expression, and gastric cancer growth and metastasis. Mechanistically, we revealed that demethylase ALKBH5 regulated the level of the N6‑methyladenosine (m6A) modification in the 3'UTR and CDS region of the ZKSCAN3 mRNA to promote ZKSCAN3 expression, mediated the binding of ZKSCAN3 to the VEGFA promoter region to regulate VEGFA transcription, and participated in MNNG-induced gastric cancer cell migration, invasion, VM formation, cell spheroid formation, stem cell-like marker expression and ultimately gastric cancer progression. In addition, our study revealed that ALKBH5-ZKSCAN3-VEGFA signaling was significantly activated during MNNG-induced gastric carcinogenesis, and further studies in gastric cancer patients showed that ALKBH5, ZKSCAN3, and VEGFA expression were upregulated in cancers compared with paired gastric mucosal tissues, that ALKBH5, ZKSCAN3, and VEGFA could serve as important biomarkers for determining patient prognosis, and that the molecular combination showed greater prognostic value. These findings provide a theoretical basis for developing gastric cancer interventions for NOCs and for determining gastric cancer progression.
PURPOSE:To enhance a drying property, separability and lubricating property imparting effect, by using an aqueous solution containing a specific amount of gum or an aqueous solution containing a specific amount of the gum and alcohol as a dental release composition. CONSTITUTION:All of the fruits or resins of plants can be used as gum and, for example, gum arabic or tragacanth gum is used and the content of the gum is pref. 1-40wt.%. As alcohol, all of water-soluble alcohols can be used and methanol, ethanol or the like are designated and pref. contained in an amount of 1-40wt.%. By the above-mentioned constitution, a release agent excellent in the separability of a resin and the lubricating property imparting effect of the surface of the resin and capable of also using a photopolymerizable resin is obtained.
In the present invention, an FE device and a BE device communicate using two wireless communication routes in a separate state. Approaching of each device is determined in both devices immediately prior to a docking state by monitoring of a wireless communication state. Wireless communication between the two devices is then stopped, and both devices enter a freeze state (operation-limited state). When the docking state is then formed, wired communication is established between both devices. Then, when an unfreeze input occurs, both devices return to a normal operation state. Both devices temporarily enter the freeze state also when a state change from the docking state to the separate state occurs.
Skeletal dysplasias are a heterogeneous group of disorders presenting mild to lethal defects. Several factors, such as genetic, prenatal, and postnatal environmental may contribute to reduced growth. Fourteen families of Pakistani origin, presenting the syndromic form of short stature either in the autosomal recessive or autosomal dominant manner were clinically and genetically investigated to uncover the underlying genetic etiology. Homozygosity mapping, whole exome sequencing, and Sanger sequencing were used to search for the disease-causing gene variants. In total, we have identified 13 sequence variants in 10 different genes. The variants in the HSPG2 and XRCC4 genes were not reported previously in the Pakistani population. This study will expand the mutation spectrum of the identified genes and will help in improved diagnosis of the syndromic form of short stature in the local population.
The purpose of this study is to validate novel screening tools for the evaluation and management of malnourished infants and children in the developing world. The study will validate 2-D diffusion point of care testing (POCT) for the rapid analysis of leptin and adiponectin, as these cytokines have been shown to predict mortality in malnourished infants and children. The study will enroll 20 participants, 10 overweight or obese adolescents presenting to the Duke Division of Pediatric Endocrinology outpatient clinics, in whom leptin is expected to be high and adiponectin low, and 10 premature or small for gestational age infants hospitalized in the Duke Transitional Care Nursery, in whom leptin is expected to be low and adiponectin high. Informed consent will be obtained and 0-1 mL of blood will be collected and analyzed using the 2-D POCT and commercial ELISA assays. To reduce potential risks associated with venipuncture and/or finger or heelstick, blood draws for the purposes of this study will take place only when blood sampling is performed at the request of the primary provider, and an attempt will be made to utilize scavenge samples from infants where applicable. The POCT will be validated against the commercial ELISA assays. The investigators will analyze the results of each assay in addition to the means and standard deviations of the POCT and ELISAs and will consider the POCT valid if their variation from ELISA is \<20%. The long-term goal of this project is to utilize this novel technology to identify and treat high-risk malnourished infants and children before they have reached the stage of critical, life-threatening illness.
Hospital-level care at home (HCaH) is a modern alternative to traditional inpatient hospitalization (TIH) for acutely ill adults which is cost-effective without impacting patient mortality. Additional outcomes comparing HCaH and TIH have been studied including hospital readmission and post-acute care admission. There is convincing evidence that suggests a trend in the reduction of readmissions following acute hospitalization in the home. Additionally, post-acute care admissions have been significantly reduced following HCaH compared to TIH. The concept of a home hospital allows patients to remain home during acute illness and stay at home longer following discharge, thereby avoiding the need for hospital readmission and post-acute care placement. This research is increasingly important to the aging population in the United States that seeks a safe and beneficial alternative to overwhelmed medical facilities.
Participants meet with self-directed care program staff called brokers to receive a program orientation, share perceptions of their current life situation and mental health status, and review past year behavioral health service use as well as participants' views of service helpfulness. This culminates in participants' choice of recovery goals and development of an individual budget to pay for for services and material goods directly related to recovery goals. After budget approval by the program supervisor, brokers make purchases. At quarterly meetings, brokers and participants discuss the latter's progress toward recovery goals and create the next quarter's budget. After receiving 12 months of SDC services, participants are helped to transition back to usual community mental health services.
BACKGROUND: Meckel diverticulum (MD) is an important cause of gastrointestinal bleeding in children. Small bowel capsule endoscopy (SBCE) is a first-line examination method applied to patients with obscure gastrointestinal bleeding, but there are few studies on its application in children with MD. This article aims to provide evidence in favor of the auxiliary diagnosis of MD in children by analyzing its characteristics using SBCE.
METHODS: We retrospectively collected the clinical data of patients with suspected MD.
RESULTS: A total of 58 children were included in this study. All 58 children presented overt gastrointestinal bleeding (bloody stool or melena). Capsule endoscopy identified protruding lesions in 2 cases, double-lumen changes in 30 cases (all considered as MD), vascular lesions in 7 cases, intestinal mucosal inflammatory lesions in 3 cases, ulcers or erosion in 3 cases, and no obvious abnormalities in SBCE in 12 cases. Both SBCE and technetium-99 scans were performed for 24 cases, 22 of which were diagnosed MD by their combined results, giving a diagnostic coincidence rate of 91.7%. Eight cases were highly suspected as MD but were negative for the technetium-99 scan and positive for SBCE.
CONCLUSION: SBCE has high accuracy in the diagnosis of MD in children, especially when performed in combination with a technetium-99 scan, which can greatly improve the diagnostic rate of MD in children.
PURPOSE:To obtain a pharmaceutical for local administration, excellent in effects on atrophia of endometriosis tissues, establishment of gestation, etc., by holding danazol in a matrix base and, as necessary, blending a release promoter therewith. CONSTITUTION:A pharmaceutical for local administration obtained by holding danazol in a matrix base (e.g., silicone rubber or ethyl cellulose) and, as neces sary, blending a release promoter (e.g., Polysorbate 60(R), Polysorbate 80(R) or glycerol) therewith. The above-mentioned pharmaceutical is formed into a T-shaped or Ota ring-like intrauterine pharmaceutical and applicable to intra uterine or intravaginal local administration. The content of the danazol in the above-mentioned pharmaceutical is 80-200mg, preferably 100-180mg in using as an intrauterine pharmaceutical and the composition weight ratio is set so as to provide 20-50pts. danazol, 50-80pts. matrix base and 0.5-8pts. release promoter.