anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The invention relates to a natural care moisturizing hand cream which is prepared, by weight, by olive oil, cortex mori radicis, honey and rose. The natural care moisturizing hand cream does not contain any chemical substances, is non-toxic and harmless, and cannot cause any damage to human health. The natural care moisturizing hand cream softens the cuticle and enables the skin to be soft, tender, smooth and moist. The natural care moisturizing hand cream has the function of continuously moisturizing the skin and prevents the skin from being dry and rough. The natural care moisturizing hand cream has the effects of sun care and skin whitening, is fresh and cool in texture, easy to absorb and high in degree of moisturizing, and is also capable of repairing the damaged skin and enhancing elasticity. The natural care moisturizing hand cream obviously diminishes fine wrinkles and dry lines on hands, tightens the skin of hands, repairs the damaged skin from the bottom layer of the skin, awakens vitality of the skin to the maximum extent, helps resist damage from the outside, enables the tired-looking skin to be moisturized like in sweet dew, improves ossein generation of the skin, repairs the skin from the deep layer, and rehabilitates the skin to achieve a tightened effect.
The present invention relates to a multifunctional patch and a method for producing the multifunctional patch. More specifically, the present invention relates to a multifunctional patch and a method for producing the multifunctional patch. The multifunctional patch comprises a bio coating cloth having a bonding side which is bonded to a portion of human body skin; a bonding member which is entirely fixated to the bonding side of the bio coating cloth; a release paper one side of which coated with a plastic material such that the bonding member is capable of being repeatedly attached to or detached from the release paper. The bio coating cloth is standardized by its size and form and thus is bonded to the release paper. The bio coating cloth is formed by printing a light mixing material after coating the light mixing material on an elastic fiber cloth. The light mixing material comprises a first mixture including amethyst, tourmaline, loess, bentonite, illite, and Maeksseomseok; and a second mixture including one or more selected from the group consisting of silicone, urethane, ink and polyethylene resin, and the first mixture and the second mixture being mixed at a ratio of 1 to 3 : 9 to 7. A multifunctional patch according to the present invention enhances the health of human body by pain relief, sudomotor promotion, blood circulation, nervous system control, fatigue recovery and others, and has environment-friendly characteristics which are harmless to the human body by bonding the multifunctional patch to the skin such that the multifunctional patch emits anions and far-infrared rays. A multifunctional patch according to the present invention is capable of inhibiting generation of allergies and increasing health performance by maintaining excellent antimicrobial and antimold effects. Further, a multifunctional patch according to the present invention has an effect that it is capable of realizing a skin care effect more efficiently by forming the multifunctional patch in various sizes or forms, enabling the multifunctional patch to be used for a variety of applications, producing the multifunctional patch inexpensively and easily, and bonding the multifunctional patch to acupuncture point regions existing on the human body.
Pelvic floor muscle training (PFMT) is the first line therapy recommended by NICE for the treatment of SUI. It was first described by Arnold Kegel almost 60 years ago. PFMT exercises help the patient strengthen the muscles of the pelvic floor by the repeated high-intensity, rapid pelvic muscle contractions of both slow and fast twitch muscle fibres. The training of these muscles is difficult particularly when women have trouble in the perception of their PFM. This results in poor motivation and compliance with a Cochrane review suggesting that only 15-20% of women comply with the regimen.

Whole body vibration (WBV) exercise has been developed as a new modality in the field of physiotherapy. Whole body vibration (WBW) has a positive effect on muscle strength and rate of force. Stochastic WBV causes up to 12 muscle contractions per second which cannot be achieved by routine PFM exercise with supervision of a physiotherapist. The Galileo machine is a unique device for applying whole-body vibration. The investigators aim to audit their treatment of whole body vibration. This would be done using the patient global impression of improvement scale (PGI-I) and routine quality of life and symptoms questionnaires (International Consultation on Incontinence Female lower Urinary Tract Symptoms Questionnaire -ICIQ-FLUTS and Pelvic Floor Distress Inventory - PFDI) to be completed by the patient at initial appointment and 12 weeks after treatment and pelvic floor muscle assessment carried out at initial appointment and at 12 weeks. Patients will also have a qualitative interview with the Urogynaecology team to assess if therapy was found to be suitable and acceptable to patients.
The invention belongs to the traditional Chinese medicine field, and relates to a pharmaceutical composition preventing children from repeated cold and a preparation method therefor. The pharmaceutical composition is composed of the following medicinal materials, by weight, 10-22 parts of mulberry leaf, 10-18 parts of lilium brownii, 12-22 parts of radix bupleuri, 12-22 parts of fructus amomi, 12-18 parts of flos farfarae, 8-14 parts of chrysanthemum, 8-12 parts of semen brassicae, 6-12 parts of white perilla leaf, 6-10 parts of tendril-leaved fritillary bulb, 4-8 parts of dried orange peel and 4-12 parts of licorice. The pharmaceutical composition has functions of dispelling wind and heat, relieving cough, resolving phlegm, rectifying qi, invigorating spleen, clearing heart, calming nerves, transforming dampness and promoting appetite. The pharmaceutical composition has outstanding curative effects on symptoms of fever, cough, nasal discharge, nasal obstruction, vomit, diarrhoea and the like caused by child cold. The medicinal materials selected for the pharmaceutical composition have reasonable compatibility, are low in cost and have no toxic or side effects. The pharmaceutical composition is suitable for children, and worth of wide popularization in clinic.
PROBLEM TO BE SOLVED: To obtain a composition which is useful for improving valetudinarianism, nourishment robustness, fatigue resistance and anemia improvement and can safely be applied. SOLUTION: This composition for nourishment robustness or valetudinarianism improvement contains Panax ginseng C.A. Mey., Equus asinus L., and either one or both of Polygonatum sibiricum Red. and Cordyceps sinensis (Berk.) Sacc. The composition for nourishment robustness or valetudinarianism improvement further contains one or more adjuvants.
B-ultrasonography,Pathological examination and gene detection Diagnostic Test:B-ultrasonography The purpose of this study is to carry out \<Sup\>18\<Sup\>F-FDG PET/CT dynamic scans and Pathological examination of metastatic central lymph nodes in newly diagnosed patients with papillary thyroid cancer, and to compare imaging findings of B-ultrasonography , genomics, and pathology at the same time. The intrinsic relationship between tissue characteristics and the diagnostic value of \<Sup\>18\<Sup\>F-FDG PET/CT dynamic imaging in metastatic central lymph nodes with papillary thyroid cancer are discussed.
Celiac disease is an autoimmune-like disorder induced in genetically predisposed individuals by dietary proteins from wheat (gluten). Its frequency reaches 1% in Europe.

In celiac patients, gluten induces small intestinal villous atrophy and, as a consequence, malnutrition. Celiac disease treatment relies on a long-life strict gluten-free diet that allows clinical and histological recovery and prevents long-term complications (autoimmune diseases, osteoporosis and malignancies). Remission is attested by total villous recovery on duodenal biopsy performed after one year of gluten free diet. Yet, in adults, systematic follow-up of biopsies for several years after gluten free diet initiation has recently revealed persistent villous atrophy in more than 40 % of cases with an increased risk in older patients (up to 56%). Lack of mucosal healing has been associated with the risk of complications in celiac, notably a risk factor for fractures and lymphoma. It is therefore necessary to define strategies to obtain and accelerate full recovery. Iron deficiency is strongly associated with celiac disease and is generally viewed as a consequence of small intestinal lesions and a symptom of malnutrition. Our preliminary clinical retrospective study showed more frequent iron deficiency anemia in celiac patients with (20/70; 29%) than without (11/88; 12.5%) villous atrophy (p = 0.015; OR: 2.78). Our previous experimental study suggests that iron deficiency may sustain tissue damage and delay mucosal recovery in celiac disease. Indeed the transferrin receptor (CD71) is overexpressed in the gut epithelium in case of iron deficiency and can interact with secretory IgA1 present in large amounts in the intestinal lumen of CD patients. Crosslinking of CD71 by polymeric IgA1 can induce production of inflammatory cytokines. Our working hypothesis is therefore that iron deficiency maintains aberrant expression of CD71 at the gut epithelial surface that sustains intestinal inflammation and epithelial damage. Iron supplementation of celiac patients with villous atrophy and iron deficiency may accelerate mucosal healing, villous recovery and remission.
Cancer remains one of the leading causes of death worldwide and poses a significant challenge to effective treatment due to its complexity. Angiogenesis, the formation of new blood vessels, is one of the cancer hallmarks and is a critical process in tumor growth and metastasis. The pivotal role of angiogenesis in cancer development has made antiangiogenic treatment a promising strategy for cancer therapy. To develop an effective therapy, it is essential to understand the basics of the physiological and tumor angiogenesis process. This review presents the primary factors related to physiological and tumor angiogenesis and the mechanisms of angiogenesis in tumors. We summarize potential molecular targets for cancer treatment by focusing on the vasculature, with the VEGF/VEGFR pathway being one of the most important and well-studied. Additionally, we present the advantages and limitations of currently used clinical protocols for cancer treatment targeting the VEGF/VEGFR pathway.
Participants in this group will receive a matching placebo on a daily basis for 6 months. To maintain masking, there are two doses of the matching placebo provided to participants depending on participant body weight at randomization: 1.) less than 30kg will receive 15mg po once daily or 2.)greater or equal to 30kg 30mg po once daily.
Participants randomized to the Treatment as Usual (TAU) group will continue to receive outpatient medical treatment of encopresis according to best practice guidelines by the pediatric gastroenterologist. Additionally, participants in the TAU group will receive a 2-hour long individual appointment with a doctoral level clinician with extensive experience in behavioral treatments for encopresis.
In order to observe temporal trends in management of VTE a first cohort of 5000 consecutive unselected patients treated for acute VTE will be recruited. This cohort will take approximately 9 months to recruit. Potential patients must be assessed for eligibility within 30 days of their acute VTE diagnosis. They will be followed prospectively for 36 months.
Participants received deoxycholic acid 2 mg/cm\^2 administered in 0.2 mL SC injections, up to 10 mL per treatment session at intervals of approximately 1 month for up to a maximum of 6 treatments. Participants with CR SMFRS Grade 4 (extreme).
The purpose of this study is to establish the esophageal pathology findings as imaged with tethered capsule microscopy in subjects with Parkinson Disease. Images from patients with Parkinson disease will be compared to our previously obtained images in healthy subjects to establish the spectrum of esophageal pathologies occurring in patients with Parkinson disease by OCT imaging.

In the case of imaging internal luminal organs, like the esophagus, OCT light is delivered via a long catheter. We have developed a new technique termed Tethered Capsule Endomicroscopy (TCE). TCE involves swallowing a tethered capsule that acquires cross-sectional microscopic images of the entire esophagus as it traverses the luminal organ via peristalsis or is pulled up towards the mouth using tether. The catheter is connected to the imaging system, and the side-viewing optical beam rotates either proximally by a motorized rotary joint or distally by a micro-motor, effectuating circular scanning of the lumen wall. Three-dimensional OCT of the entire length of the lumen can be acquired by simultaneous rotation and translation of the focused OCT beam creating a helical pattern.
Idiopathic normal pressure hydrocephalus (iNPH) affects mainly aged populations. The gradual shortening of telomere length (TL) is one of the hallmarks of aging. Whereas the genetic contribution of TL to the iNPH is incompletely understood. We aimed to investigate the causal relationship between TL and iNPH through the Mendelian randomization (MR) analysis. We respectively obtained 186 qualified single nucleotide polymorphisms (SNPs) of TL and 20 eligible SNPs of iNPH for MR analysis. The result of MR analysis showed that genetically predicted longer TL was significantly associated with a reduced odd of iNPH (odds ratio [OR] = 0.634 95% Confidence interval [CI] 0.447-0.899, p = 0.011). The causal association remained consistent in multivariable MR (OR = 0.530 95% CI 0.327-0.860, p = 0.010). However, there was no evidence that the iNPH was causally associated with the TL (OR = 1.000 95% CI 0.996-1.004, p = 0.955). Our study reveals a potential genetic contribution of TL to the etiology of iNPH, that is a genetically predicted increased TL might be associated with a reduced risk of iNPH.
PURPOSE:To provide the titled composition having improved oxidation stability of the drug component, by compounding isoprenyl-carboxylic acid useful as a carcinostatic agent, remedy for psoriasis, etc., with a specific antioxidant such as butylhydroxytoluene, etc. and/or ascorbic acid, etc. CONSTITUTION:The external remedy composition containing the compound of formula is compounded with (A) an antioxidant selected from butylhydroxy- toluene, butylhydroxyanisole, ascorbic acid, fatty acid ester, tocopherol and gallic acid ester and/or (B) an antioxidant selected from ascorbic acid, erythorbic acid, their sodium salts, cysteine, sodium bisulfite and sodium metabisulfite. The amount of the antioxidant is 0.005-0.5% of the composition. The oxidation of the compound of formula can be inhibited by the process. The base of the composition is oleaginous, aqueous or emulsion one, and the components (A), (B), and (A) and (B) are used as main additives for the oleaginous, aqueous and emulsion- type bases, respectively.
FIELD: medicine, oncology. SUBSTANCE: method involves the use of the conventional treatment of oncological patients involving chemotherapy and/or radiation therapy and additional use of viburnum, pagoda-tree japonica, garlic, mugwort alcoholic tinctures and befungin. Method shows the effectiveness in patients with cancer of breast, uterus, ovary, gastroenteric tract, lung and other organs. Method has no contraindications and complications and ensures to exclude relapses and obtain the complete tumor regression in some cases. EFFECT: enhanced effectiveness of treatment. 3 cl, 5 ex
PURPOSE:To obtain a composite forming a stable partition wall easily for the separation of blood serum or blood plasma by centrifugation, by forming the composite having specific gravity in a specified range and consisting of a mixture of a thixotropic agent, viscous liquid material and a water insoluble amine compound. CONSTITUTION:Pulverized powder of silica, alumina etc. is used for a thixotropic agent and a composite made by viscous liquid material (acrylic resin oligomer, maleic acid modified material of polybutadiene etc.) having a strong mutual action with said agent or the viscous liquid material (liquid paraffin, liquid polybutane etc.) not having the strong mutual action with said agent or a mixture of both viscous liquid material and a mixture of said material and >=8 carbon number water insoluble amine (dodecylamine etc.) and also, having 1.03- 1.08 specific gravity, is used for a blood plasma separation agent. When said  mixture is added to the sample blood and is centrifuged after the blood is coagulated, a partition wall is formed in the middle of blood serum and blood clot  and the blood serum is separated and is sampled easily without crumbling the partition wall at the time of taking out the blood serum by inclining spits. Also,  the composite is stable without aging.
Each patient will receive training for 4 weeks, 3 times per week. Each training session will last 30 minutes. Training will be performed by music therapists board-certified in RAS.
INTRODUCTION: This study analysed treatment outcomes in a patient cohort diagnosed with spondylodiscitis, who received adjunct hyperbaric oxygen treatment (HBOT) in addition to antibiotic therapy at our clinic. Important considerations included the timing of HBOT initiation on treatment success, and recurrence rates.
METHODS: We retrospectively reviewed the records of all patients diagnosed with spondylodiscitis who received HBOT at the Underwater and Hyperbaric Medicine Clinic in Gulhane Training and Research Hospital, between 1 November 2016 and 25 October 2022. The patients received HBOT at 243.2 kPa for a total of 120 minutes per session, once daily for five days a week for a total of 30 sessions.
RESULTS: Twenty-five patients with spondylodiscitis were evaluated before and after combination HBOT and targeted antibiotic treatment. After treatment, patients had lower median (range) visual analogue pain scores (8 [4-10] vs 3 [0-7], P < 0.001) and C-reactive protein (22.3 [4.3-79.9] mg·L⁻¹ vs 6.8 [0.1-96.0] mg·L⁻¹, P = 0.002) and lower mean (standard deviation) white blood cell counts (8.8 [3.5] x 109·L⁻¹ vs 6.1 [1.6] x 109·L⁻¹, P = 0.002). When patients were examined (median) 48 months (2-156 months) after the completion of treatment, there were no persistent cases of spondylodiscitis.
CONCLUSIONS: Combination HBOT with targeted antibiotic therapy effectively managed our cohort of patients diagnosed with spondylodiscitis. Hyperbaric oxygen treatment was safe, with no complications experienced. Moreover, HBOT may have helped to eliminate persistence and recurrence of symptoms with long term follow-up. A randomised controlled study with a larger number of patients is needed for more definitive conclusions.
In the US approximately 1.4 million men identify as transgender, a number that is likely to increase with greater recognition of this condition. Gender affirming hormone therapy (GAHT), which attempts to more align the physical appearance with the identified gender, is the primary medical intervention for transgender people and is recognized as medically necessary. GAHT has been associated with increased cardiovascular risk (increased blood pressure, dyslipidemia, and endothelial dysfunction) in transgender men receiving androgens, however little is known about the mechanisms for these changes and few interventions have been proposed. We hypothesize that the altered hormonal milieu is the major driver of increased cardiovascular risk in trans men, and the initiation of testosterone will have effects on lipid profiles, blood pressure and endothelial function. In addition, androgen exposure within the female vascular system is associated with sympathetic nervous system dysregulation. We propose this dysregulation is mediated through rapid dyslipidemia associated with GAHT in trans men receiving androgens. The first aim of this proposal is to test the hypothesis that testosterone treatment in trans men increases sympathetic activation, blood pressure and endothelial dysfunction. Recent studies have demonstrated that vascular endothelial cells are crucial to the pathogenesis of inflammatory disease. Thus, the cholesterol lowering effects of certain statins appear to be mediated, in part, by their action on the endothelium. Important to these studies, HMG-CoA reductase inhibitors (i.e. lipid dependent statins) not only lower LDL-C, but improve both central sympathetic and peripheral microvascular function. Therefore, our second aim is to test the hypothesis that lipid dependent statin therapy will decrease sympathetic activation and improve endothelial function in trans men taking GAHT indicating that the increased sympathetic activity and endothelial dysfunction are mediated by the increased LDL-C with androgens. Trans men undergoing GAHT and cisgender female controls will be examined twice: at baseline, and again following 30 days of treatment with the lipid dependent statin, atorvastatin, in a randomized cross over design. Using microneurography, measures of sympathetic nerve activity (SNA) in response to stressors will be quantified and analyzed within- and between groups and cardiovascular metrics including beat to beat blood pressure and conduit-level endothelial function will be assessed at baseline and with atorvastatin treatment. These novel and innovative studies will illuminate the sympathetic and vascular changes that accompany GAHT, and our atorvastatin intervention will provide insight into the mechanism for these changes as well as provide a method to reduce these risks in trans men undergoing GAHT. This is a critical gap in our knowledge; once these early changes can be identified and quantified, subsequent studies can track these changes over longer trajectories of treatment.
<P>PROBLEM TO BE SOLVED: To provide a melanin synthesis inhibitor, and to provide a cosmetic.  <P>SOLUTION: A melanin synthesis-inhibiting experiment using mouse B16 melanoma cells has been carried out as an indicator to find a substance having an excellent melanin synthesis-inhibiting effect. Consequently, a synergic effect for the melanin synthesis inhibition by a pine bark extract and a tea extract has been found. Namely, the present invention relates to a melanin synthesis inhibitor containing the pine bark extract and the tea extract. Preferably, the pine bark extract contains ≥20 mass% of OPC(oligomeric proanthocyanidin) and ≥5 mass% of catechin compounds. More preferably, the tea extract contains ≥60 mass% of catechin compounds. More preferably, the melanin synthesis inhibitor is prepared in a solid or solution form such as tablets, pills, capsules, powder, or solution. The present invention furthermore relates to a cosmetic containing the melanin synthesis inhibitor, preferably liquid cosmetics, skin lotions, beauty creams, lotions, packs, ointments, milky lotions, cleansing foams, cleansing gels, or soaps.  <P>COPYRIGHT: (C)2009,JPO&INPIT
This arm AGA patient receive 5%Minoxidil milky lotion to use for 6 month. Record efficacy and safety as described.