anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
After cleaning the area with antiseptic solution, the sterilized linear USG probe (Esaote MyLab30®, CA631 high-frequency probe, United Kingdom) was covered. The flat probe was placed between two transverse processes on the paramedian plane; transverse processes, superior costotransverse ligament and pleura were consecutively visualized. The linear ultrasound probe was fixed to the T3-T4 vertebra level. The skin and subcutaneous tissue were anaesthetized with 2% lidocaine, then 22 gauge 100 mm needle (Stimuplex ®; B Braun, Melsungen, Germany) was led in a cranial-cephalic direction to the paravertebral gap. Trapezius, rhomboid, erector spinae muscles were crossed by seeing the tip of the needle. Transverse processes were reached and the intercostal muscles were passed. When the needle reached the paravertebral level, a 20 mL of 0.25% bupivacaine was applied as a single administration.
A system for improving worker's compensation programs. Employee presence is detected by using proximity sensors at different places in the workplace. For example, where a company has different workshops, offices, rooms, or other areas, detection of a worker's presence in one or more of the areas allows more accurate information to be used to calculate liabilities such as risk of injury. Data about a worker's presence, duration of presence, repeated presence, or other characteristics of a worker in an area are sensed and logged by a digital system. The system can store and process the data locally, or the data (or a derivative of the data) can be transferred to other entities for storage, processing, analysis or other purposes. For example, the presence data can be sent to insurance providers for calculation of accurate premiums, risk, payouts, etc.
Patients who have been treated in the ICU for a prolonged period of time often have a high degree of immobility. In this context, a state of generalized weakness associated with muscle atrophy (ICUAW) develops in approximately 40% of ICU patients. The severity of generalized weakness may be individual in each patient. It is certain that especially elderly patients and patients with prolonged immobilization have an increased incidence of ICUAW. Symptoms can be highly variable depending on the severity of the course. Some patients report weakness of the extremities to paresis and weakness of the respiratory muscles. Weakness of the respiratory musculature can lead to a prolonged weaning process of mechanical ventilation, prolonging the stay in the ICU. Functional impairments due to ICUAW may also persist many years after the ICU stay. If ICUAW is diagnosed promptly, outcome can be improved by targeted early mobilization. Early mobilization is defined as mobilization in the first 72 h from ICU admission. However, there are numerous barriers to the implementation of early mobilization in critically ill patients, so this remains a major challenge.

Various studies have shown that patients can benefit from a high level of mobilization. For example, Scheffenbichler et al. showed that a high dose of mobilization was associated with increased independence of patients after discharge. The level of mobilization showed positive effects not only in this study, but also in Paton and colleagues. They were able to show that achieving a higher level of mobility (according to the Intensive Care Mobility Scale) was associated with improved outcome at six months. They found that achieving a higher level of mobilization positively affected the health status of patients, whereas increasing the number of mobilizations did not.

With device-assisted mobilization, patients could be mobilized to standing position early and more frequently. The aim of this pilot study is to test whether mobilization of critically ill patients with ventilatory support using device-assisted mobilization leads to increased mobilization to standing (IMS 4) or beyond.
PROBLEM TO BE SOLVED: To obtain an gent for ophthalmic diseases having excellent ocular tension lowering action by using an alkylenedioxybenzene derivative as a component. SOLUTION: This agent contains a compound of the formula I [X is single bond, O, CO or CHOH; Y is a group of the formula II (Z is pyridyl or phenyl), etc.; (m) is 2-5; (n) is 1-3], its salt or its hydrate as an active component. The compound of the formula I is e.g. 5- 4-[4-(2-methoxyphenyl)-1- piperazinyl]butoxy}-1,3-benzodioxol. The agent is useful for the prevention and treatment of glaucoma, ocular hypertension, etc., especially high-tension glaucoma. It can be formed in the form of oral drug, injection, eye lotion, ointment, etc., and is administered usually at a daily dose of 0.001-10mg/kg.
Skeletal disorders encompass a wide array of conditions, many of which are associated with short stature. Among these, Desbuquois dysplasia is a rare but severe condition characterized by profound dwarfism, distinct facial features, joint hypermobility with multiple dislocations, and unique vertebral and metaphyseal anomalies. Desbuquois dysplasia is inherited in an autosomal recessive manner, with both the DBQD1 (MIM 251450) and DBQD2 (MIM 615777) forms resulting from biallelic mutations. Specifically, DBQD1 is associated with homozygous or compound heterozygous mutations in the CANT1 gene, while DBQD2 can result from mutations in either the CANT1 or XYLT1 genes. This review synthesizes the findings of 111 published case reports, including 54 cases of DBQD1, 39 cases of DBQD2, and 14 cases of the Kim variant (DDKV). Patients in this cohort had a median birth weight of 2505 g, a median length of 40 cm, and a median occipitofrontal circumference of 33 cm. The review highlights the phenotypic variations across Desbuquois dysplasia subtypes, particularly in facial characteristics, joint dislocations, and bone deformities. Genetic analyses revealed a considerable diversity in mutations, with over 35% of cases involving missense mutations, primarily affecting the CANT1 gene. Additionally, approximately 60% of patients had a history of parental consanguinity, indicating a potential genetic predisposition in certain populations. The identified mutations included deletions, insertions, and nucleotide substitutions, many of which resulted in premature stop codons and the production of truncated, likely nonfunctional proteins. These findings underscore the genetic and clinical complexity of Desbuquois dysplasia, highlighting the importance of early diagnosis and the potential for personalized therapeutic approaches. Continued research is essential to uncover the underlying mechanisms of this disorder and improve outcomes for affected individuals through targeted treatments.
Solution Focused Approach (SFA) interview technique is an approach that can be used by nurses who have important roles in the protection, maintenance and promotion of health in healthcare services. Because the SFA interview technique can be integrated into all dimensions of health, it enables children and adolescents to be aware of their own strengths and skills and to improve their skills. This raised awareness encourages individuals to start and maintain change. The earlier the awareness of individuals is raised, the higher the achievement level of the approach will increase. Further studies can be conducted in which the duration of the SFA interview technique follow-ups is longer. Moreover, it can be suggested that studies be conducted to analyze the cost-effectiveness of this approach.

All health professionals in general and, specifically nurses, should be educated about the SFA interview technique strategies. Nurses who carry out the SFA interviews conducted using the SFA interview technique should enable individuals to realize their own strengths. The number of interviews can be determined in accordance with the topic and the data obtained from individuals. If the interviews are carried out with school children-adolescents, attention should be paid to conduct interviews with their families. Enabling individuals to reach a solution using the SFA interview technique strategies is the major point of interviews. This result may not appear immediately. Interviews should be continued with patience to find what works in resistant individuals.

After these interviews are completed, interviews should be continued with the individuals periodically. To enable individuals to maintain their nutrition and exercise behaviors, interviews should be carried out with adolescents and their families at least twice in a month after the SFA interviews. Nurses who conduct SFA interviews can carry out individual interviews or group interviews in Endocrinology Polyclinics, Family Health Centers, or at schools as a school nurse.
In a double-blind, randomized, treatment-withdrawal study, 35 pediatric patients less than 1 year of age who were diagnosed with GERD, primarily by history of vomiting (spitting up) and irritability (fussiness), were treated for up to 4 weeks with famotidine oral suspension 0.5 mg/kg or 1 mg/kg administered once daily for patients less than 3 months of age and administered twice daily for patients 3 months to less than 12 months of age. Caregivers were instructed to provide conservative treatment including thickened feedings. After 4 weeks of treatment, patients were randomly withdrawn from the treatment and followed an additional 4 weeks for vomiting (spitting up), irritability (fussiness) and global assessments of improvement. The study patients ranged in age at entry from 1.3 to 10.5 months (mean 5.6 ±2.9 months), 57% were female, 91% were white and 6% were black. Most patients (27/35) continued into the treatment-withdrawal phase of the study. Most patients improved during the initial treatment phase of the study. Results of the treatment-withdrawal phase were difficult to interpret because of small numbers of patients.
Macrophages play a central role in initiating, maintaining, and terminating inflammation. For that, macrophages respond to various external stimuli in changing environments through signaling pathways that are tightly regulated and interconnected. This process involves, among others, autoregulatory loops that activate and deactivate macrophages through various cytokines, stimulants, and other chemical mediators. Adaptor proteins play an indispensable role in facilitating various inflammatory signals. These proteins are dynamic and flexible modulators of immune cell signaling and act as molecular bridges between cell surface receptors and intracellular effector molecules. They are involved in regulating physiological inflammation and also contribute significantly to the development of chronic inflammatory processes. This is at least partly due to their involvement in the activation and deactivation of macrophages, leading to changes in the macrophages' activation/phenotype. This review provides a comprehensive overview of the 20 adaptor molecules and proteins that act as negative regulators of inflammation in macrophages and effectively suppress inflammatory signaling pathways. We emphasize the functional role of adaptors in signal transduction in macrophages and their influence on the phenotypic transition of macrophages from pro-inflammatory M1-like states to anti-inflammatory M2-like phenotypes. This endeavor mainly aims at highlighting and orchestrating the intricate dynamics of adaptor molecules by elucidating the associated key roles along with respective domains and opening avenues for therapeutic and investigative purposes in clinical practice.
Saline (rest controlled) will be induced by i.v. injection of 25 mL of saline over 3 minutes with the subject supine. Includes blood draws and fasting requirements.
The present invention relates to a jianling contraceptive medicine for contraception, which is a contraceptive physic liquor prepared by dichlorine biguanide ethyl hydride, benzene bromoamine solution, gentian violet and distilled water. When in use, the physic liquor is installed in a bottle with holes at a tubular top end for preparation, and after the ejaculation, the bottle provided with physic liquor enters the vagina in 3 to 5 minutes and is extruded, so the physic liquor instantly flows into the vagina through the holes at the tubular top end. The bottle stops for a moment, the bottle stops being pressed, and a mixed liquor of physic liquor and the sperm are absorbed from the bottle. Through the certification of a plurality of years of clinical application, the results have none example of pregnancy by using the medicine. The medicine has the advantages of convenient operation, low cost, safety, sanitation and reliability. The contraception efficiency can reach 100%, and the present invention is a specially effective medicine of the present contraceptive medicines.
BACKGROUND: Instrumentation failure (IF) is a major complication associated with growth-sparing surgery for pediatric spinal deformities; however, studies focusing on IF following each surgical procedure are lacking. We aimed to evaluate the incidence, timing, and rates of unplanned return to the operating room (UPROR) associated with IF following each surgical procedure in growth-sparing surgeries using traditional growing rods (TGRs) and vertical expandable prosthetic titanium ribs (VEPTRs).
METHODS: We reviewed 1,139 surgical procedures documented in a Japanese multicenter database from 2015 to 2017. Of these, 544 TGR and 455 VEPTR procedures were included for evaluation on a per-surgery basis. IF was defined as the occurrence of an implant-related complication requiring revision surgery.
RESULTS: The surgery-based incidences of IF requiring revision surgery in the TGR and VEPTR groups were 4.3% and 4.0%, respectively, with no significant intergroup difference. Remarkably, there was a negative correlation between IF incidence per surgical procedure and the number of lengthening surgeries in both groups. In addition, rod breakage in the TGR group and anchor-related complications in the VEPTR group tended to occur relatively early in the treatment course. The surgery-based rates of UPROR due to IF in the TGR and VEPTR groups were 2.0% and 1.5%, respectively, showing no statistically significant difference.
CONCLUSIONS: We found that IF, such as anchor related-complications and rod breakage, occurs more frequently earlier in the course of lengthening surgeries. This finding may help in patient counseling and highlights the importance of close postoperative follow-up to detect IF and improve outcomes.
DNF training along with conventional treatment. In this programme, emphasis was placed on first attaining the correct craniocervical flexion action, with minimal activity of the superficial cervical flexor muscles. The craniocervical flexion action involves a specific craniocervical movement (nodding - "yes" movement) of head such that it remains in contact with the supporting surface. Once the correct action had been achieved, participants were instructed in the use of the sphygmomanometer to guide the training of the CCF muscle contraction at the various incremental levels of pressure (22 to 30 mmHg, progressively inner range positions).
Patients receive Akt inhibitor MK-2206 PO on days 2, 9, 16, and 23; anastrozole PO daily on days 1-28; and goserelin acetate SC on day 1 (premenopausal patients only). Treatment repeats every 28 days for 4 courses in the absence of disease progression or unacceptable toxicity.
This study will use a randomised controlled trial to assess the impact of a case-finding strategy for vertebral fractures on bisphosphonate and other drug prescribing in primary care. A sample of postmenopausal women aged 65-80 years from Bristol will be invited to take part. They will be individually randomised into either the intervention or control arm in a 2:1 ratio in favour of controls. The participants in the intervention arm will attend their GP practice to receive a simple 15 minute assessment, and if found to be at high risk of vertebral fractures will have a thoracolumbar X-ray; those randomised to the control arm will receive current standard methods used to identify women at high risk of vertebral fractures (no active intervention). Follow-up will be for three years.

Baseline measurements will be taken from women in each arm via self-completion postal questionnaire, including current prescriptions of any bisphosphonate or other osteoporosis medication. The women in the intervention arm will attend their GP practice and receive a simple 15 minute assessment, and if found to be at high risk of vertebral fractures will have a thoracolumbar X-ray arranged for them. They will be given a leaflet on lifestyle interventions aimed to improve bone health. Women in the control arm will be sent the same leaflet. Post-intervention questionnaires will be sent to all women asking about fractures and current prescriptions of any bisphosphonate or other osteoporosis medication. The primary outcome will be the proportion of women prescribed medication for secondary fracture prevention in the intervention arm compared to the control arm. Secondary outcomes will include the proportion of fractures in the intervention versus control arm, and compliance with bisphosphonate or other drug prescribing.

This study will be performed subject to Research Ethics Committee (REC) approval, including any provisions of Site Specific Assessment (SSA), and local Research and Development approval. This study will be conducted in accordance with the Research Governance Framework for Health and Social Care and Good Clinical Practice.
Child secondhand smoke exposure (SHSe) is a significant public health problem that has been linked to asthma, acute respiratory illnesses, otitis, and SIDS, and is associated with increased risk of cancers, cardiovascular disease, and behavior problems. This project will test the effectiveness of a comprehensive multilevel intervention to reduce young children's SHSe in minority and medically underserved communities known to have the highest SHSe-related morbidity and mortality risk. First, we will provide a clinic-level quality improvement (CQI) intervention to improve the care of pediatric patients with SHSe in four pediatric clinics in North and West Philadelphia. We will then randomize eligible parents visiting the CQI clinics into either a home-level behavioral counseling intervention (CQI+BC) or a home-level attention control intervention (CQI+A). In addition to clinic-level intervention, CQI+BC provides personalized, behavioral counseling with intensive skills training and support where SHSe occurs (in the home), as well as systems navigation to facilitate access to and effective use of reimbursable nicotine replacement therapy and smoking cessation medication. Participants will complete assessments at pre-treatment, 3-month end of treatment, and 12-month follow-up.
Placebo matching to 10 mg BI 474121 administered as uncoated tablets with 240 milliliter of water after subjects fasted overnight for at least 10 hours. This arm was part of Part 1: randomised, placebo-controlled, single-blind.
BACKGROUND AND OBJECTIVE: To evaluate long-term posterior segment findings in children recovering from multisystemic inflammatory syndrome (MIS-C) associated with severe acute respiratory syndrome coronavirus 2.
PATIENTS AND METHODS: Our study included 22 patients who were admitted to an intensive care unit with a diagnosis of MIS-C between November 2021 and March 2022, and 25 healthy controls. The study included pediatric patients who had an eye examination an average of 12.35 ± 2.18 months after recovery from MIS-C. Detailed eye examinations and measurements of all participants were obtained retrospectively from patient files. Posterior segment parameters were measured using swept-source optical coherence tomography (OCT) and OCT-angiography (OCT-A); these parameters included peripapillary retinal nerve fiber layer (pRNFL) thickness, central macular thickness (CMT), subfoveal choroidal thickness (SCT), macular vascular densities (VD), and foveal avascular zone (FAZ) area.
RESULTS: Mean age was 9.7 ± 3.6 years in the MIS-C group and 10.6 ± 2.8 years in the healthy control group (P = 0.316). There were no statistically significant differences between the MIS-C group and the healthy control group in terms of pRNFL thickness, CMT, and SCT. However, in the MIS-C group, the macular superficial vascular plexus and deep vascular plexus showed significantly lower VD in the superior, inferior, nasal, and temporal quadrants compared to the healthy controls (P < 0.05 for all). A comparison of the superficial and deep FAZ area parameters of both groups showed no statistically significant difference (P > 0.05).
CONCLUSIONS: We showed that patients who had recovered from MIS-C had retinal vascular damage at the long-term follow-up. Following up with these patients after recovery with OCT and OCT-A, which are noninvasive methods commonly used in the detailed evaluation of the posterior segment of the eye, could be beneficial for understanding the long-term effects of MIS-C on retinal microvasculature. [Ophthalmic Surg Lasers Imaging Retina 2024;55:518-526.].
OBJECTIVE: To analyze the physical fitness characteristics of elite freestyle skiing aerials athletes, thereby enhancing the understanding of exercise physiologists, sports scientists, and coaches regarding the demands in this discipline.
METHODS: After health screenings, 29 athletes from the Chinese National Freestyle Skiing Aerials Team were divided into elite and general groups, including males and females. Physical fitness indexes were determined through literature reviews, expert interviews, and the Delphi method, followed by physical fitness tests assessing body morphology, physiological function, and physical quality. Data normality was verified using the Shapiro-Wilk test. Differences between the two groups were then evaluated using independent sample t-tests or Mann-Whitney U tests, after which effect sizes were calculated to assess the magnitude of the differences.
RESULTS: Significant body morphology differences were noted between elite and general groups in fat-free body weight, leg, and waist circumferences (P < 0.05). Male athletes in the elite group exhibited a significantly lower percentage of body fat (P < 0.05), whereas the reduction in body fat percentage among female elite athletes was not statistically significant. In terms of physiological function assessment, elite athletes demonstrated superior performance in both maximum anaerobic capacity and relative maximum anaerobic capacity compared to their counterparts in the general group (P < 0.05). Notably, the difference in maximum anaerobic capacity was highly significant among male athletes (P < 0.01), and the relative maximum anaerobic capacity among female athletes was also markedly significant (P < 0.01). Regarding physical quality indexes, elite athletes outperformed those in the general group in all aspects except for the quick v-up and 12-minute run tests (P < 0.05 or P<0.01).
CONCLUSION: Elite athletes exhibit superior physical fitness characteristics compared to general athletes, attributable to differences in age, years of training, and their participation in ongoing specialized physical training within structured, cyclical programs. Specifically, elite athletes demonstrated higher fat-free body weight, larger waist and leg circumferences in terms of body morphology. Particularly, male athletes showed a trend towards lower body fat percentage. Physiologically, they exhibited stronger anaerobic metabolism capabilities. In terms of physical quality, elite athletes displayed superior limb strength, lower limb explosive power, and specialized core strength, along with better speed, agility, and overall coordination.