anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The investigators hypothesize that sagittal alignment and thoracic volumes will predict successful treatment outcomes as measured by improved pulmonary function and health-related quality of life in adolescent idiopathic scoliosis patients at a minimum 20-year follow-up. Significant focus has been placed on the coronal plane in order to determine treatment indications for scoliosis, but with new understanding about the important of sagittal balance and pulmonary function, the treatment indications should be broadened. Thus, the investigators propose the following study to explore parameters associated with a durable and acceptable outcome following scoliosis treatment, minimizing the need for further surgery and to optimizing quality of life and pulmonary health. Beyond the standard radiographs and Scoliosis Research Society (SRS) scores, this study undertakes a comprehensive assessment of health-related quality of life, chest asymmetry and body satisfaction scoring, sagittal plane parameters, and 3D modeling of the childhood and current spinothoracic deformity. Thus, the investigators research team is uniquely poised to determine broader treatment indications for scoliosis. The overarching goal of this research effort is to determine new parameters based on thoracic volume and sagittal plane alignment in addition to coronal deformity in order to determine the appropriate treatment threshold for surgical intervention in children with adolescent idiopathic scoliosis.
The invention discloses a Chinese and western medicine composition for treating the breast cancer, and a preparation method and an application thereof. The Chinese and western medicine composition comprises, by weight, 3-7 parts of Hedyotis diffusa, 7-15 parts of barbed skullcap herb, 1-3 parts of nicotinic acid and 11-19 parts of inositol. The preparation method comprises the following steps: mixing the Hedyotis diffusa, barbed skullcap herb and inositol, adding deionized water with the mass 3.8 times the total mass of above three substances, and carrying out microwave treatment for 8 min to prepare a mixture A; and mixing the mixture A with nicotinic acid, carrying out ultrasonic treatment at 40 DEG C for 20 min, and stirring the obtained mixture at 45 DEG C until the mixture is dry in order to obtain the Chinese and western medicine composition. The Chinese and western medicine composition ahs substantial medicine effects and low toxic and side effects under the synergism of the raw materials when used in treatment of the breast cancer in order to obtain an unexpected technologic effect. The Chinese and western medicine composition has the advantages of simple and easily available raw materials, small taking dosage, high curative effect, and no toxic or side effects. The Chinese and western medicine composition used as an anti-breast cancer medicine has the characteristics of simple preparation method, low cost and suitableness for large-scale promotion.
PURPOSE:To provide a glucosyl transferase inhibitor containing a safe natural substance extracted from tamarind husk which is the seed skin of tamarind belonging to the family Leguminosae as an active ingredient and usable as an oral cavity agent and a food or drink having imparted anticarious action. CONSTITUTION:This agent utilizes tamarind husk separated and discarded in the production of tamarind seed gum useful as a thickening agent for food processing from the albumen of tamarind seed. Concretely, tamarind husk is extracted with water, monohydric or polyhydric aliphatic alcohol, lower aliphatic ketone, halogenated hydrocarbon, aliphatic hydrocarbon or their mixture to obtain a substance inhibiting the glucosyl transferase activity as the extract. The glucosyl transferase inhibitor is produced by using the extract as an active component. The active ingredient is used as an additive for the preparation of an oral cavity agent and a food or drink imparted with anticarious action. The agent, etc., can be applied to the feed of a caries-susceptible livestock and pet and the food and drink for man.
This study aimed to analyze the impact of the lockdown period due to COVID-19 pandemic on the mental health status of healthcare workers and identify the related risk factors of psychosomatic distress. We conducted an online questionnaire survey to investigate the general demographic characteristics, perceived stress level, adult attachment style (AAS), family cohesion and adaptability, social support, sleep state, emotional state, and physical health of healthcare workers during the lockdown period due to the pandemic in 2022. We compared the mental health status between doctors and nurses, and further analyzed the factors influencing sleep, emotions, physical symptoms, and severe psychosomatic distress separately. For factors that showed statistical significance in the univariate analysis, forward stepwise regression was used for logistic regression analysis to identify risk factors for the corresponding issues. A total of 622 healthcare workers participated in the survey. Among the participants, 121 (19.5%) reported sleep problems, 209 (33.6%) had negative emotional states, and 147 (23.6%) reported physical health problems. There were 48 (7.7%) healthcare workers with severe psychosomatic distress. Compared to the group of nurses, the group of doctors exhibit a higher prevalence of emotional issues, physical health problems and psychosomatic distress. Perceived stress was identified as a risk factor for sleep disturbance, while living with others during quarantine and family adaptability were identified as protective factors. Higher educational background and perceived stress were identified as risk factors for negative emotion, while subjective support was identified as a protective factor. Perceived stress and coming from a rural area were also identified as risk factors for physical health. Overall, for the comparison between the no psychosomatic distress and severe psychosomatic distress groups, perceived stress was identified as a risk factor for severe psychosomatic distress, while subjective support was identified as a protective factor. Healthcare workers' potential mental and physical health problems are related to their educational background, family cohesion and adaptability, perceived stress and social support. This makes it clearer on how to deal with and prevent adverse consequences when facing stressful situations.
An ebastine dispersible tablet comprises the following components: ebastine, disintegrating agent, filling agent, corrigent, glidant, lubricant and adhesive solution. The ebastine is dispersed in the adhesive solution in a hot-melt mode. The adhesive solution is taken as a carrier to form a hot-melt solid-liquid dispersoid. The ebastine dispersible tablet is obtained by tabletting the hot-melt solid-liquid dispersoid together with the disintegrating agent and the filling agent after wet granulation, drying and total mixing. A preparation method of the ebastine dispersible tablet includes the steps of proportionally dispersing the ebastine in the adhesive solution of 86-100DEG C in a hot-melt mode, wherein the dispersing time period is 5 to 20 minutes; mixing the filling agent, the disintegrating agent and the hot-melt adhesive together to pelletize; adding the disintegrating agent, the corrigent, the glidant and the lubricant after 30-45 meshes of wet granulation, 4-6 hours of drying at 45-55 DEG C and 35-40 meshes of granulation; and obtaining the ebastine dispersible tablet after total mixing and tabletting. The ebastine dispersible tablet is rapid in dissolution, high in dissolution rate, non-toxic, high in safety, capable of being rapidly disintegrated and dispersed, and good in flavor and taste.
Ventricular Tachycardia (VT) is a common complication of ischemic heart disease that is often life threatening. Ventricular tachycardia is defined as three or more beats of ventricular origin in succession at a rate greater than 100 beats per minute. There are no normal QRS complexes associated with VT, and the rhythm is usually regular. Patients with VT experience unpleasant heart palpitations, dyspnea, and syncope, all of which decrease their overall quality of life. They also suffer the consequences of impaired hemodynamics, loss of cardiac efficiency, and are at an increased risk of sudden cardiac death (SCD), which accounts for approximately half of all deaths from patients with cardiovascular disease.

Historically, antiarrhythmic medications served as the first line therapy for the treatment of VT, in spite of low efficacy and high recurrence rates. But in recent years, internal cardioverter defibrillators (ICDs) have become the treatment of choice. Although, ICDs are effective in terminating most arrhythmias, rarely does so without some episodes requiring poorly tolerated shock therapy. Ablative therapy offers an important option for frequent control with the potential for long-term VT elimination. Radiofrequency catheter ablation offers the ability to provide immediate control of recurrent VT. Since the early 2000's, strategies, tools, and techniques have been improving to identify key ablation sites and to deliver effective lesions.

Radiofrequency ablation is successful in treating some but not all arrhythmias. With non irrigated technology it has been difficult to ablate ischemic VT. This may be due to an inadequate lesion size. Irrigated electrodes were developed to create larger lesions. Open irrigation at the catheter tip not only produces larger lesions, but also helps reduce the risk of coagulum (clots) and charring due to high temperatures.
The present work aimed to evaluate the expression profile of genes related to stem cells (SC) characteristics during the acquisition of the multidrug resistance (MDR) phenotype in the chronic myeloid leukemia (CML). For this, the K562 (non MDR) and FEPS (MDR) cell lines were used. K562 cells had resistance induced by exposure to daunorubicin (DNR), and induction was confirmed by flow cytometry with an increase in ABCB1 expression in K562 cells treated at the highest concentration. Real-time PCR gene expression analysis showed a direct relationship in the expression of OCT4 and ABCB1 genes, with an increase in ABCB1 expression after exposure to DNR, followed by an increase in OCT4 gene expression. This direct relationship was confirmed in the MDR FEPS cells that had the ABCB1 gene silenced. For the ALOX5 gene, we observed an inverse relationship with ABCB1, with a decrease in the expression of ALOX5 in the DNR-transformed K562 cells, and an increase in the expression of this gene when ABCB1 was silenced in the FEPS cells. Thus, during the acquisition of the MDR phenotype by the K562 cells, it was possible to observe that there is an increase in the expression of ABCB1, accompanied by the expression of OCT4, while the expression of ALOX5 is decreased.
BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type‑2 inflammatory disease of the upper airways, with severe impairment of quality of life. Persons affected by NSAID-exacerbated respiratory disease (NERD) usually present with highly dynamic recurrence of polyps and disease despite prior treatment with sinus surgeries, oral corticosteroids, and aspirin desensitization (ATAD). Biologic therapy has fundamentally changed the choice of therapeutic concept; however, limited data exist on subgroups such as NERD patients. The aim of the current article is to report on a multicenter retrospective study on add-on therapy with dupilumab, omalizumab, and mepolizumab in patients with NERD.
METHODS: This is a retrospective cohort study of patients (NERD+, status after ATAD) in three reference centers in Germany (Munich, Mainz, Berlin). Subjective and objective parameters were collected at 4, 8, and 12 months after biologic therapy initiation in accordance with current EPOS/EUFOREA (European Position Paper on Rhinosinusitis and Nasal Polyps/European Forum for Research and Education in Allergy and Airway Diseases) guidelines. Biologic agents were chosen depending on availability and patient characteristics.
RESULTS: Treatment was commenced in 122 patients meeting the criteria for CRSwNP and NERD. The endoscopic polyp score, SNOT-22 questionnaire score, visual analogue scoring of total symptoms/severity of disease, and sense of smell (psychophysical testing with Sniffin'Sticks/Brief Smell Identification Test, B‑SIT; Sensonics, Inc., Haddon Heights, NJ, USA) improved significantly after 4 and 12 months of add-on therapy (p < 0.0001). All three biologic agents significantly improved one or more disease parameter. Adverse events were not life threatening but led to change of biologic agent in 4 cases. Patients rated biologic therapy significantly better than ATAD, with improved long-term disease control.
CONCLUSION: Add-on biologic therapy is effective, safe, and widely accepted among CRSwNP + NERD patients. Future studies might allow for personalized algorithms with sequential surgery, ATAD, and/or biologic therapy.
-The number of elderly population is increasing in the world and in Turkey. Dementia increases with age. The most common type of dementia is Alzheimer's disease. As the Alzheimer's disease stage progresses, patients' dependency level in daily living activities increases and they need care support. Alzheimer's patients are usually cared for at home by family members. Caregivers may experience many difficulties in the home environment due to lack of knowledge in disease management. This study will be conducted to determine the effect of the education given to caregivers of Alzheimer's patients registered to home health services on their knowledge and attitudes towards Alzheimer's disease. The research was planned as a single-blind randomized controlled experimental study. The research will be conducted on caregivers of Alzheimer's patients registered to Giresun Province Bulancak State Hospital Home Health Services between 20 December 2023 and 20 December 2024. The population of the research will be the caregivers of Alzheimer's patients registered to Giresun Province Bulancak State Hospital Home Health Services. The sample of the research will be the caregivers of 60 patients who meet the research criteria and agree to participate in the research. The data of the study will be collected with the "Patient and Caregiver Introduction Form", "Alzheimer's Disease Information Scale" and "Dementia Attitude Scale". Necessary institutional permissions and ethics committee approval will be obtained for the research. In the research, caregivers in the experimental group will be trained about Alzheimer's disease in 2 sessions, 15 days apart, in the training hall of the hospital. No intervention will be applied to caregivers in the control group during the research. Necessary institutional permission and ethics committee approval will be obtained for the research. The analysis of the data will be done in a computer environment by an expert statistician.
AIMS: There is limited information on the sex-specific longitudinal changes of left ventricular ejection fraction (LVEF) after an acute heart failure (AHF) hospitalization. We aimed to investigate whether LVEF trajectories over time and their impact on mortality and AHF readmission rates differ between men and women.
METHODS AND RESULTS: We conducted a retrospective sex-specific analysis of longitudinal LVEF measurements (n = 9581) in 3383 patients with an index hospitalization for AHF in a single tertiary-level hospital. Statistical techniques suited for longitudinal data analysis were used. The mean age of the sample was 73.8 ± 11.2 years, and 47.9% were women. The mean LVEF was 49.4 ± 15.3%. At a median follow-up of 2.58 years (interquartile range 0.77-5.62), we registered 2197 deaths (64.9%) and 2597 AHF readmissions in 1302 (38.5%) patients. The longitudinal analysis showed that women had consistently higher LVEF values throughout the follow-up with both trajectories characterized by an early peak-approximately at 1 year-followed by decreasing values in men but a plateau in women. Multivariate between-sex comparisons across LVEF categories revealed that women had lower rates of AHF readmissions when LVEF ≤40%. On the contrary, women displayed an excess risk of AHF readmissions when LVEF >60%. A trend in the same direction was found for cardiovascular and all-cause mortality.
CONCLUSION: Sex was a significant factor in determining the follow-up trajectory of LVEF and predicting differences in outcomes after an AHF admission. The findings suggest that women have a higher risk of AHF readmissions at higher LVEF values, while men have a higher risk at lower LVEF values. For all-cause and cardiovascular mortality, the same direction of the association was inferred but they were not significant.
To date most investigations of UE rehabilitation have examined single interventions. However, combining 2 efficacious interventions may enhance effectiveness. Both functional task training and strength training are beneficial for promoting improved upper extremity function, but they have seldom been studied as a coupled therapy. The research proposed in this project will examine the effect on UE function of adding UE resistive exercises to functional task training. Secondary aims are to examine the effect of stroke severity on the response to therapy, the interrelationship between therapy-induced neural changes and movement composition and functional changes with therapy, and test for retention of UE function gains over 6 months. Individuals with chronic hemiparesis from stroke will complete baseline testing and then be randomly assigned to either the functional task + strength training group or the functional task training alone group. Each group will train 4 hours/day, 3 days/week for 4 weeks. Each will perform 3 hours of functional task training per session. The strengthening group will then complete 1 hour of UE progressive resistance exercises while the functional task training alone group will complete gravity eliminated range of motion exercises for 1 hour. All subjects will be post-tested and then complete follow-up testing 6 months later.
BACKGROUND: In-stent restenosis (ISR) is a crucial factor that affects the long-term efficacy of intracranial bare metal stent (BMS) implantation for intracranial atherosclerotic stenosis (ICAS). Patients with intracranial ISR are at a high risk of recurrent ischaemic events. The NOVA intracranial drug-eluting stent (DES) trial demonstrates that a DES can reduce ISR and stroke recurrence after intracranial bare stent implantation. However, the application of balloon-expanded DES necessitates specific vascular conditions. The objective of this study is to assess the safety and efficacy of self-expanding DES for treating symptomatic ICAS (sICAS).
METHODS: This is a prospective, multicentre, randomised, controlled, superiority clinical trial that is conducted in 16 clinical trial centres in China. This study aims to recruit 208 patients with sICAS. Eligible subjects are randomly assigned to two groups at a ratio of 1:1. The experimental group is treated with DES (Xinwei intracranial DES system). The control group is treated with BMS (Wingspan intracranial stent system). All subjects are followed up within 7 days after surgery or before discharge; 30 days after surgery; and 6, 12 and 24 months after surgery. The primary outcome of the trial is the incidence of ISR at 6 months after surgery to verify the safety and efficacy of intracranial DESs. After 6 months of follow-up, the clinical summary report is issued for product registration application, and the follow-up of 12 months and 24 months after operation is conducted to evaluate the medium and long-term efficacy.
ETHICS AND DISSEMINATION: The study involving human participants is reviewed and approved by the Ethics Committee of Drugs (devices) Clinical Experiment in Henan Provincial People's Hospital (reference number: AF/SC-08/05.0) and other research centres participating in the clinical trial (supplemental file 2). The results yield from this study will be presented at international conferences and sent to a peer-reviewed journal to be considered for publication.
TRIAL REGISTRATION NUMBER: Registered on 2 November 2023 with Chinese clinical trial registry. Registration number is ChiCTR2300077271.
PURPOSE:To obtain a hair tonic cosmetic, capable of promoting peripheral bloodstream of the scalp, activating a hair-matrix cell and excellent in hair growth and preventing effects on alopecia and dandruff by blending an extract of a weeping golden bell known as an antidotal, a drainage, an antiphlogistic and a diuretic agent therein. CONSTITUTION:The hair tonic cosmetic is obtained by blending an extract of a weeping golden bell which is an ingredient extracted from a fruit of Forsythia suspensa Vahl. and Forsythia viridissima Lindl. native to China or Forsythia koreana Nakai native to the Korean Peninsula of the family Oleaceae with an extracting solvent therein. Oleanolic acid which is a triterpenoid, phillyrin, pinoresinol, arctiin, etc., which are lignans, forsythosidae A, etc., which are caffeic acid derivatives are cited as the extracted ingredient. A 10-90% aqueous solution of ethanol is preferred as the extracting solvent. This hair tonic cosmetic can be formulated into a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, etc.
Patients with unresectable HCC will be treated with TACE in combination with oral sorafenib administration. TACE will be accomplished with gelatin microspheres (Embospheres) following delivery of 125 mg/m2 of cisplatin. Oral sorafenib (400 mg BID) will start the next day after the first TACE treatment.
Mandibular asymmetry refers to dimensional differences between the left and right sides of the mandible in terms of size, form and volume. This condition may result in problems with functionality as well as appearance. Early intervention is often deemed optimal for addressing mandibular asymmetry; however, there is a lack of consensus regarding the diagnostic approach and strategy for identifying asymmetries in developing individuals. The purpose of this narrative review (NR) is to provide a clinician-focused update on the radiographic techniques for identifying mandibular asymmetries in orthodontic patients. Selective database searches were conducted until November 2023 to assess the available literature on mandibular asymmetry diagnosis. A health-sciences librarian developed a search strategy utilizing appropriate terms associated with mandibular asymmetry diagnosis. The databases used were Web of Science, Embase, Scopus, Liliacs and PubMed. Fifty-two studies were included in this review and data regarding the evaluation of mandibular asymmetries were presented with a narrative approach delineating clinical indications based on retrieved findings. There is no unanimous consensus on the method for diagnosing mandibular asymmetries. Cone beam computed tomography emerges as the preferred examination method for diagnosing mandibular asymmetry, thanks to the assessment of a 3D structure with a 3D image. However, the use of only orthopantomography could be advisable as a first-line diagnostic tool in children due to less radiation exposure.
The intervention for the entire cohort will be "Taking Charge of your Heart Health" Cardiac Education Classes, delivered via four 2.5-hour group-based classes at TotalCardiology Rehabilitation in Calgary, Canada. Classes review physiology, risk factors, medications, nutrition, exercise, and stress management. Patients are required to complete these classes prior to starting CR exercise sessions.