anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Parkinson's Disease (PD) patients with motor fluctuations will be screened for the presence of Small Intestinal Bacterial Overgrowth (SIBO) using two hydrogen breath tests. SIBO-positive individuals will be eligible to enroll, and randomized to receive either rifaximin or placebo. This study includes two treatment regimens (including a placebo control), designed so that all patients will receive the active drug at some point during the trial. Motor outcomes will be followed for 3 or 6 months following enrollment, depending on the treatment arm to which the subject has been assigned. The primary endpoint is to assess the effect of rifaximin treatment to decrease "off" time in SIBO-positive PD patients.

This pilot study will support the design of a larger, randomized controlled trial investigating the effect of SIBO eradication on reducing motor complications in PD patients with motor fluctuations. The current proposal is designed to demonstrate our ability to detect and treat SIBO in PD patients with motor fluctuations, to inform selection of the best SIBO detection method, to determine the optimal timeline for assessing motor endpoints, and to estimate the duration of benefits after treatment.
PURPOSE:To provide the titled controlling agent containing a substance composed of the constituent component of eurocidin and exhibiting a specific absorption peak in ultraviolet absorption spectrum, as an active component. CONSTITUTION:An agent for controlling the function of mastocyte is obtained by using a substance composed of the constituent component of eurocidin and exhibiting an absorption peak (including shoulder) at about 300-350nm in ultraviolet absorption spectrum, as an active component. The above substance can be separated from eurocidin or a filtrate of a cultivation product of an eurocidin-producing microorganism using a high-performance liquid chromatography (HPLC). As an alternative method, the substance can be produced by culturing Streptoverticillium albireticuli in a conventional medium and separating from the culture medium by conventional method. The separation of the substance from the culture liquid can be carried out e.g. by ion-exchange resin process, or an adsorption and desorption using an adsorbent.
An omega-7 fatty acid composition from a raw material  Tribonema  sp. obtained under heterotrophy and/or mixotrophy and a method of cultivation of  Tribonema  sp. by way of heterotrophy and/or mixotrophy. The content of omega-7 fatty acid in the omega-7 fatty acid composition is 30% to 70%. The method of cultivation involves nutrient composition of a culture medium, cultivation conditions, and operation steps of a cultivation process. An application of the method in the production of  Tribonema  biomass, lipid rich in omega-7 fatty acid, products with the biomass and/or the lipid as the raw material, etc.
Patients with metabolic dysfunction-associated fatty liver disease (MAFLD) often present with concomitant metabolic dysregulation and alcohol consumption, potentially leading to distinct clinical outcomes. We analyzed data from 8043 participants with MAFLD in the Thai National Health Examination Survey with linked mortality records. According to the MAFLD criteria, 1432 individuals (17.2%) were categorized as having the diabetes phenotype, 5894 (71.0%) as the overweight/obesity phenotype, and 978 (11.8%) as the lean metabolic phenotype. Over 71,145 person-years, 916 participants died. Using Cox proportional hazard models adjusting for physiological, lifestyle, and comorbid factors, both diabetes (adjusted hazards ratio [aHR] 1.59, 95% CI 1.18-2.13) and lean metabolic phenotypes (aHR 1.28, 95% CI 1.01-1.64) exhibited significantly higher mortality risk compared to the overweight/obesity phenotype. A J-shaped relationship was observed between daily alcohol consumption and the risk of all-cause mortality. Daily alcohol intake exceeding 50 g for women and 60 g for men increased the all-cause mortality risk among MAFLD individuals with the lean metabolic phenotype (aHR 3.39, 95% CI 1.02-11.29). Our study found that metabolic phenotype and alcohol consumption have interactive effects on the risk of all-cause mortality in patients with MAFLD, indicating that evaluating both factors is crucial for determining prognostic outcomes and management strategies.
Myeloablative regimens are the backbone of hematopoietic stem cell transplantation (HSCT) and are associated with prolonged periods of cachexia/anorexia, nausea/vomiting, mucositis, and compromised gut integrity (CGI). The toxicities associated with HSCT often lead to prolonged periods of poor oral intake and may result in overt malnutrition. CGI decreases oral tolerance to foods, reduces Quality of Life (QOL) and functional status, delays the transition from the hospital to home setting, and increases the risk of the development of gut-derived infections. Probiotics are nutritional supplements that contain a defined amount of viable microorganisms and upon administration confer a benefit to the host. Clinical trials in adults receiving organ transplants have found probiotics decrease the incidence of infection, the duration of antibiotic use, the incidence of multiorgan failure and systemic inflammation. Children and adolescents undergoing HSCT, experience similar clinical challenges suggesting probiotics may have a therapeutic value in the setting of HSCT. This study is to evaluate the safety and feasibility of administering probiotics to children and adolescents undergoing HSCT.
PURPOSE: To obtain a washing liquid for destroying the in-vivo foreign matter deposits in the celom by the impulsive waves formed via the breakdown induced by a laser by dissolving a mixture composed of the metals of the iron family of a periodic system and the salt or complex compd. of magnesium or calcium and incorporating the soln. thereof into this liquid. CONSTITUTION: The aq. soln. contg. the mixture composed of the metals of the iron family of the periodic system and the salt or complex compd. of the magnesium or calcium an such salt or complex compd. are dissolved at the max. 50mmol/l conc. is used as the washing liquid for destroying the in-vivo foreign matter deposits in the human or animal tissues or celom by the impulsive waves formed via the breakdown induced by the powerful pulse laser beams in the liquid. Cobalt, manganese and nickel in a bivalent form as well as bivalent or tervalent iron are used as the iron family metals. The pH value of the soln. is recommended to be adjusted to a range of 4 to 8 and more particularly recommended 4.5 to 6.5 when the destruction of the calculus in the vital tissues and more particularly the human vital tissues is executed.
Aligned with the NIH priority of addressing disparities in new HIV infections and the UNAIDS call for implementing combination HIV prevention approaches, the proposed study will examine the impact and cost associated with Suubi4Her, an innovative combination intervention that aims to prevent HIV risk behaviors among 14-17 year-old girls living in communities heavily affected by poverty and HIV/AIDS in Uganda. In sub-Saharan Africa (SSA), family financial stress can compromise the support available to adolescents, with girls living in poverty exhibiting higher rates of risky sexual behavior increasing their vulnerability in acquiring HIV and other STIs. At the same time, internalizing mental health disorders such as depression and low self-esteem disproportionately affect girls and may be contributing to HIV risk behavior. Against that backdrop, support over and above health and sex education is needed to help adolescent girls in SSA successfully transition into young adulthood. The proposed study is informed by two previously tested interventions - asset-based matched savings accounts (YDA) and family strengthening through Multiple Family Groups (MFG) which have successfully been implemented with younger primary school-going adolescents. Suubi4Her will test the theory that youth cognitive and behavioral change is influenced by economic stability while examining if enhanced intra-familial support and communication are needed to maintain positive behavioral health functioning and reinforce engagement in protective health behaviors. Nested within 47 secondary schools across four districts of Uganda heavily impacted by HIV/AIDS, 1260 older girls (ages 14-17 at enrollment) will be randomly assigned (at school level) to one of three study conditions: 1) Savings (Youth Development Accounts - YDA)- with a 1:1 incentive match rate - for education and microenterprise development; 2) Savings (YDA) + MFG intervention; 3) Control condition receiving standard health and sex education provided in schools. The intervention will be provided for 24 months. Assessments at baseline,12, 24, and 36-months will include biomedical data to measure our primary sexual-risk outcome:1) proportion of girls' biologically confirmed STIs (Gonorrhea, Trichomonas and Chlamydia); and secondary outcomes: 2) the proportion of new HIV infections during the study period, and 3) for HIV+ girls, viral load and CD4 as markers of ART adherence. The study aims are to: 1) Examine whether the Suubi4Her intervention is effective in protecting adolescent girls against known HIV risk factors (including economically-motivated sex and intimate partner violence). 2) Elucidate the effects of the Suubi4Her intervention on behavioral health functioning (i.e., depression, self-efficacy and hopelessness) and examine the effects of these variables as potential mechanisms of change, mediating the relationship between each intervention and HIV risk reduction. 3) Evaluate the cost-effectiveness of each intervention condition. The study will also use the Child Depression Index and Beck Hopelessness Scale to examine the efficacy of interventions in improving mental health in this vulnerable population.
Vitamin D is known to be related with calcium and bone metabolism. Recently, vitamin D has been shown to play an important role in innate and acquired immunity, cytokine release, inflammatory response, and may be associated with a reduced risk of infection. Studies have reported that serum 25-hydroxyvitamin D concentrations are significantly lower in COVID-19 infected patients than in uninfected patients. In addition, it has been shown that people with higher serum 25-hydroxyvitamin D level would produce significantly more antibodies after COVID-19 vaccination.Thus, it is clear that vitamin D plays a pivotal but still not well understood role in the immune response to COVID-19 infection and vaccination.

Patients with inflammatory skin diseases (e.g., psoriasis, atopic dermatitis, acne vulgaris, hair loss, idiopathic urticaria, etc.) are often observed to have deteriorated skin condition after COVID-19 vaccination, which not only affects the patient's quality of life, but also seriously affects the patient's willingness to complete vaccination. Since many studies have shown a high negative correlation between the severity of inflammatory disease and serum 25-hydroxyvitamin D levels, it is likely that the COVID-19 vaccination also impacts serum 25-hydroxyvitamin D levels. Therefore, this study aimed to analyze the changes in serum 25-hydroxyvitamin D levels and acne severity in patients with acne vulgaris before and after the third dose of COVID-19 vaccine.
Conventional post-prostatectomy radiation therapy (COPORT) over 7 weeks. Patients may also receive optional androgen deprivation therapy per doctor recommendation.
The invention relates to a method for treating skin diseases using live “ Penicillium notatum ” fungus. There is still little known about the “ Penicillium notatum ” fungus. Live “ Penicillium notatum ” fungus has the following functions in the treatment process: 1) as a biological producer to develop the most effective antibiotic against (particular) pathological microorganisms acting as the causative agents of a particular disease; 2) as a biological therapeutic instrument for the rational delivery of an antibiotic individually to each pathogenic microorganism; 3) as a biological instrument for the removal of dead and infected human body tissues; 4) as a biological immunizing agent protecting young regenerating skin; 5) as a biological immunizing agent protecting young skin tissue that has not succeeded to establish immunity after regeneration against a repeated attack from the disease. The treatment period for certain infectious skin diseases using live “ Penicillium notatum ” fungus lasts from three to five days. In the future, it may be possible to use live “ Penicillium notatum ” fungus for augmenting the immunity lost by people under various specific circumstances: specific conditions of work and day-to-day activity, long-time presence in space, loss of or removal from constant gravitational weight, impaired individual immunity caused by space-related factors, and the emergence of new diseases. It can supplement or replace the immunizing microflora of human internal organs. It is likely that the fungus will be domesticated and new species thereof will be bred artificially and specifically for each organ of the human body. It is essential that mankind learns how to use the live “ Penicillium notatum ” fungus in the field of medicine in view of the fact that its resilience exceeds the resilience of all life forms known to mankind, including the resilience of the microorganisms of the immunizing human microflora.
Participants will be cooled using an individualized cooling protocol with a water-perfused vest for two hours while resting. Afterwards, participants will drink 75g of D2-glucose dissolved in water and DMI will be performed.
A cell-polymeric solution is injected into an animal where the polymer crosslinks to form a polymeric hydrogel containing dispersed cells and the cells form new tissue in the animal. The polymer is biodegradable and is a natural polymer such as alginate or a synthetic polymer. The cells are chondrocytes, osteoblasts, muscle cells, fibroblasts or cells acting primarily to synthesize, secret or metabolize materials. Crosslinking of the polymer results from using cations or anions, altering the pH or changing the temperature. A polyion such as polyethyleneimine or polylysine can be added before injection to stabilize the polymeric hydrogel. A kit for tissue formation is provided by combining the cell-polymeric solution with a means for injecting the solution into an animal.
PURPOSE:To provide the subject patch agent for external use containing a specified glycoside monomer as its base component, excellent in softening of skin irradiation, reduction of pain in peeling, reduction of side effects such as madness, adhesion to the skin and peeling and useful for application to the outer skin. CONSTITUTION:A glycoside monomer represented by the formula (R is H or lower alkyl), e.g. glycosylethyl methacrylate is used as its base component and, as necessary, a (meth)acrylate polymer soluble in a water soluble polyvalent alcohol and water or in an organic solvent and capable of radical polymerization is used in combination therewith. Water and the polyvalent alcohol are blended therewith in a prescribed ratio and a specified amount of active components such as a skin irritant, an analgesic and antiphlogistic agent, a central nervous system-acting agent and an antihistamine are added thereto. The resultant mixture is irradiated with light such as ultraviolet rays in the presence of a polymerization initiator, especially a photopolymerization initiator for polymerization and crosslinking, thus giving the objective patch agent for external use. The resultant agent is capable of providing a preparation having excellent physical properties and excellent in adhesion characteristics, safety, softening of pains, etc., in use for human body.
The vitamin C2 group will receive 2 g of vitamin C intravenously administered after the induction of epidural labor anesthesia. The infusion speed will be set at 5ml/min.
Influenza A virus isolates resistant to rimantadine have been selected in cell culture and in vivo as a result of treatment. Rimantadine-resistant strains of influenza A virus have emerged among freshly isolated strains in closed settings where rimantadine has been used. Resistant viruses have been shown to be transmissible and to cause typical influenza illness (Ref. 3, 9). Substitutions at any one of five amino acid positions in the transmembrane domain of M2 confer resistance to rimantadine. The most common substitution causing resistance among influenza A (H1N1) and A (H3N2) is S31N. Other less common substitutions that cause resistance include substitutions A30F, V27A, V30A, and L26F.

Rimantadine resistance has been observed in circulating seasonal influenza and pandemic isolates from individuals who have not received rimantadine. Swine-origin influenza A (H1N1) (S-OIV) viruses that were resistant to rimantadine have been shown to contain the S31N substitution. Existing primers used for detection of adamantine resistance in seasonal viruses do not work with all tested S-OIVs (Ref. 11). The CDC should be consulted for questions regarding resistance to rimantadine in circulating influenza strains.
Atrial fibrillation, the most prevalent cardiac arrhythmia, has witnessed significant advancements in treatment modalities, transitioning from invasive procedures like the maze procedure to minimally invasive catheter ablation techniques. This review focuses on recent improvements in anesthetic approaches that enhance outcomes in catheter atrial fibrillation ablation. We highlight the efficacy of contact force sensing catheters with steerable introducer sheaths, which outperform traditional catheters by ensuring more effective contact time and lesion formation. Comparing general anesthesia with conscious sedation, we find that general anesthesia provides superior catheter stability due to reduced respiratory variability, resulting in more effective lesion formation, and reduced pulmonary vein reconnection. The use of high-frequency jet ventilation under general anesthesia, delivering low tidal volumes, effectively minimizes left atrial movement, decreasing catheter displacement and procedure time, and reducing recurrence in paroxysmal atrial fibrillation. An alternative, high-frequency low tidal volume ventilation using conventional ventilators, also shows improved catheter stability and lesion durability compared to traditional ventilation methods. However, a detailed comparative study of high-frequency jet ventilation, high-frequency low tidal volume ventilation, and conventional mechanical ventilation in catheter ablation for atrial fibrillation is lacking. This review emphasizes the need for such studies to identify optimal anesthetic techniques, potentially enhancing patient outcomes in atrial fibrillation treatment. Our findings suggest that careful selection of anesthetic methods, including ventilation strategies, plays a crucial role in the success of catheter ablation for atrial fibrillation, warranting further research for evidence-based practice.
AIMS: While prognosis of acute myocarditis with uncomplicated presentation is perceived as benign, data on long-term outcomes are scarce. We evaluated rates of myocarditis-associated cardiovascular events after a first-time hospitalization with uncomplicated acute myocarditis in patients without known heart disease.
METHODS AND RESULTS: In this retrospective nationwide population-based cohort study from 2013 to 2020, hospitalized patients with uncomplicated acute myocarditis but without known heart disease were 1:1 propensity score-matched with surgical controls hospitalized for laparoscopic appendectomy. As assessed in time-to-event analyses, the primary outcome was a composite of rehospitalization for myocarditis, pericardial disease, heart failure and its complications, arrhythmias, implantation of cardiac devices, and heart transplant. After matching, we identified 1439 patients with uncomplicated acute myocarditis (median age of 35 years, 74.0% male) and 1439 surgical controls (median age of 36 years, 74.4% male). Over a median follow-up of 39 months, compared with surgical controls, the hazard ratio for the primary composite outcome was 42.3 [95% confidence interval (CI) 17.4-102.8], corresponding to an incidence rate of 43.7 vs. 0.9 per 1000 patient-years (py) and an incidence rate difference of 42.7 (95% CI 36.7-48.8) per 1000 py.
CONCLUSION: Patients hospitalized with uncomplicated acute myocarditis and no known prior heart disease were associated with substantial risk for cardiovascular events over a follow-up of up to 8 years. This calls for a more efficient therapeutic management of this population of patients.
Derivatives of amino-benzoic acids, hydroxy-benzoic acids, cinnamic acids, urocanic acids and benzimidazols have been synthetized. The photoprotector power of each class of compounds has been tested. It is the result of four different isolated or conjugate mechanisms. Mechanism 1: absorption of ultraviolet radiations between 360 nm and 260 nm (UVB and/or UVA). Mechanism 2: prolonged absorption of ultraviolet radiations between 360 nm and 260 nm by preferential fixation and in a prolonged way at the epiderm of the human skin of the compound and this by introducing into their chemical structure sulphured or not, peptidic, amino-acid groups. Mechanism 3: induction of the melanogenesis, natural protection system of the skin. Mechanism 4: selection of a compound which is either liposoluble or hydrosoluble according to the galenic form (solution, emulsion, spray). The present invention claims the chemical structure of new compounds, their synthesis, photoprotective activity and the utilization of all the disclosed compounds in order to avoid photodermatosis consecutive to the administration of medicaments, to the use of cosmetics and/or perfumes by man.
BACKGROUND: Calcification is common in chronic vascular disease, yet its role in pulmonary hypertension due to left heart disease is unknown. Here, we probed for the role of runt-related transcription factor-2 (RUNX2), a master transcription factor in osteogenesis, and its regulation by the HIPPO pathway transcriptional coactivator with PDZ-binding motif (TAZ) in the osteogenic reprogramming of pulmonary artery smooth muscle cells and vascular calcification in patients with pulmonary hypertension due to left heart disease. We similarly examined its role using an established rat model of pulmonary hypertension due to left heart disease induced by supracoronary aortic banding.
METHODS: Pulmonary artery samples were collected from patients and rats with pulmonary hypertension due to left heart disease. Genome-wide RNA sequencing was performed, and pulmonary artery calcification assessed. Osteogenic signalling via TAZ and RUNX2 was delineated by protein biochemistry. In vivo, the therapeutic potential of RUNX2 or TAZ inhibition by CADD522 or verteporfin was tested in the rat model.
RESULTS: Gene ontology term analysis identified significant enrichment in ossification and osteoblast differentiation genes, including RUNX2, in pulmonary arteries of patients and lungs of rats with pulmonary hypertension due to left heart disease. Pulmonary artery calcification was evident in both patients and rats. Both TAZ and RUNX2 were upregulated and activated in pulmonary artery smooth muscle cells of patients and rats. Co-immunoprecipitation revealed a direct interaction of RUNX2 with TAZ in pulmonary artery smooth muscle cells. TAZ inhibition or knockdown decreased RUNX2 abundance due to accelerated RUNX2 protein degradation rather than reduced de novo synthesis. Inhibition of either TAZ or RUNX2 attenuated pulmonary artery calcification, distal lung vascular remodelling and pulmonary hypertension development in the rat model.
CONCLUSION: Pulmonary hypertension due to left heart disease is associated with pulmonary artery calcification that is driven by TAZ-dependent stabilisation of RUNX2, causing osteogenic reprogramming of pulmonary artery smooth muscle cells. The TAZ-RUNX2 axis may present a therapeutic target in pulmonary hypertension due to left heart disease.