anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE:To obtain the subject composition containing inositol nicotinate or a derivative therefrom, suppressing the development and progression of the local inflammation of the gingival tissue, thus useful for preventing and treating periodontosis. CONSTITUTION:This composition contains, as active ingredient(s), 0.001-5 (pref. 0.005-3)wt.% of inositol nicotinate and/or a derivative therefrom (e.g. inositol hexanicotinate). Other ingredients to be formulated in this composition are as follows: abrasive agent, caking agent, thickening agent, surfactant, sweetener, preservative, colorant, etc. The composition is prepared into toothpaste, tooth wash, other dentifrice, pasta for oral cavity, mouthwash, troche for oral cavity, etc.
Patients receive oral anastrozole as in arm I. Patients also receive fulvestrant intramuscularly on days 1, 14, and 28 during course 1 and then on day 28 of the subsequent courses.
Methylene Blue 100 mg capsules. Patients will receive Methylene blue (MB) capsules of 100mg every 12 hours for a total of 5 days.
Hemorrhagic pleural effusion (PE) is common in clinical practice. According to the guidelines, the etiological diagnosis of PE should focus on the identification of common diseases. In most cases, the etiology of PE can be determined by clinical history, physical examination, laboratory and imaging examinations, and pleural biopsy or video-assisted thoracic surgery (VAST). We reported a rare case of a 32-year-old woman with recurrent unilateral hemorrhagic pleural effusion (highly correlated with menstrual cycle) and chest pain that was diagnosed as thoracic endometriosis syndrome (TES) by pathological biopsy and immunohistochemistry. Later she underwent surgery combined with hormone therapy. During the follow-up, the right PE decreased, and she had no chest pain. Therefore, women of reproductive age with regular unilateral bloody pleural effusions should be alert to TES.
PURPOSE: We aimed to evaluate the effect of cervical disc herniation (CDH) and lumbar disc herniation (LDH) on female sexual functioning before and after surgical intervention.
METHODS: The current study was conducted from February 2022 to February 2023. A total of 100 sexually active female patients in their reproductive phase who were diagnosed with CDH and LDH based on physical examination and previous magnetic resonance imaging (MRI) results, as well as 50 healthy females, were enrolled. The female subjects were evaluated using the validated Arabic version of the female sexual function index (ArFSFI), a 0 to 10 visual analogue scale (VAS), the Oswestry disability index (ODI) and Beck's depression index (BDI).
RESULTS: The baseline ArFSFI domains and total scores were greatest in the controls, followed by the CDH group. The ArFSFI domains and total scores were greatest in the control group, followed by the postoperative ArFSFI domains and total scores in the cervical group. The variations in satisfaction, pain, and overall ArFSFI ratings were significant across research groups. The difference in desire, arousal, lubrication, and orgasm was substantial in the lumbosacral group, but there were no significant changes between the cervical and control groups. Postoperatively, ArFSFI domains and overall scores improved in both of the cervical and lumbar groups. Both research groups' ODI score and grade improved after surgery. Finally, both groups' BDI score and grade improved after surgery.
CONCLUSION: Female sexual dysfunctions caused by CDH and LDH improved considerably after surgery.
The medicament is a drug for curing constipation. Said drug is made up by using the Chinese medicinal materials of lianghuang (a Chinese herbal medicine), refined mirabilite, morning glory seed, Chinese angelica root, unripe bitter orange and borneol, etc.. The above-mentioned medicinal materials are proportioned, mixed, ground into fine powder, and then mixed with an appropriate quantity of sesame oil into paste, so that said drug can be used. ADVANTAGE-. The source of raw material is extensive. Said drug is easy to use, and its therapeutic effect is good.
BACKGROUND: Subclinical pulmonary tuberculosis, which presents without recognisable symptoms, is frequently detected in community screening. However, the disease category is poorly clinically defined. We explored the prevalence of subclinical pulmonary tuberculosis according to different case definitions.
METHODS: We did a one-stage individual participant data meta-analysis of nationally representative surveys that were conducted in countries with high incidence of tuberculosis between 2007 and 2020, that reported the prevalence of pulmonary tuberculosis based on chest x-ray and symptom screening in participants aged 15 years and older. Screening and diagnostic criteria were standardised across the surveys, and tuberculosis was defined by positive Mycobacterium tuberculosis sputum culture. We estimated proportions of subclinical tuberculosis for three case definitions: no persistent cough (ie, duration ≥2 weeks), no cough at all, and no symptoms (ie, absence of cough, fever, chest pain, night sweats, and weight loss), both unadjusted and adjusted for false-negative chest x-rays and uninterpretable culture results.
FINDINGS: We identified 34 surveys, of which 31 were eligible. Individual participant data were obtained and included for 12 surveys (620 682 participants) across eight countries in Africa and four in Asia. Data on 602 863 participants were analysed, of whom 1944 had tuberculosis. The unadjusted proportion of subclinical tuberculosis was 59·1% (n=1149/1944; 95% CI 55·8-62·3) for no persistent cough and 39·8% (773/1944; 36·6-43·0) for no cough of any duration. The adjusted proportions were 82·8% (95% CI 78·6-86·6) for no persistent cough and 62·5% (56·6-68·7) for no cough at all. In a subset of four surveys, the proportion of participants with tuberculosis but without any symptoms was 20·3% (n=111/547; 95% CI 15·5-25·1) before adjustment and 27·7% (95% CI 21·0-36·4) after adjustment. Tuberculosis without cough, irrespective of its duration, was more frequent among women (no persistent cough: adjusted odds ratio 0·79, 95% CI 0·63-0·97; no cough: adjusted odds ratio 0·76, 95% CI 0·62-0·93). Among participants with tuberculosis, 29·1% (95% CI 25·2-33·3) of those without persistent cough and 23·1% (18·8-27·4) of those without any cough had positive smear examinations.
INTERPRETATION: The majority of people in the community who have pulmonary tuberculosis do not report cough, a quarter report no tuberculosis-suggestive symptoms at all, and a quarter of those not reporting any cough have positive sputum smears, suggesting infectiousness. In high-incidence settings, subclinical tuberculosis could contribute considerably to the tuberculosis burden and to Mycobacterium tuberculosis transmission.
FUNDING: Mr Willem Bakhuys Roozeboom Foundation.
Use of a cosmetic composition comprising at least ethylene oxide/propylene oxide-block copolymer (I), for the inactivation and/or elimination of mites on the skin, is claimed. Use of a cosmetic composition comprising at least ethylene oxide/propylene oxide-block copolymer of formula (A-B1-A) (I), for the inactivation and/or elimination of mites on the skin, is claimed. A : polyethylene oxide block; and B1 : polypropylene oxide. An independent claim is included for cosmetic, non-therapeutic method for optical improvement and/or preservation of the appearance of human skin, comprising the cosmetic composition to inactivation and/or elimination of mites on the skin, and optionally rinsing with water after a contact time of 30 seconds to 24 hours. ACTIVITY : Acaricide. MECHANISM OF ACTION : None given.
The present invention discloses new quinolone antimicrobial medicine, and a synthetic method and the application thereof. The present invention particularly discloses sparfloxacin salts, and a synthetic method and the application thereof. Sparfloxacin reacts with polyhydroxyl monocarboxylic acid for forming the sparfloxacin salts. The sparfloxacin salts are crystalloid, and can be dissolved in water easily. A water solution of the sparfloxacin salts has high stability. The sparfloxacin salts can be prepared into an infusion solution and an injection for antimicrobial treatment. The sparfloxacin salts overcome the defects of the existing sparfloxacin salts such as unstability of a water solution of lactic acid sparfloxacin, etc.
An operator will identify the saphenous vein by using ultrasound with a linear transducer (L15-7io) in short axis view. A 22 or 24 G catheter will be advanced until the tip of the needle is seen on the ultrasound image. The needle is then advanced until blood appears in the hub. The catheter is then advanced into the saphenous vein.
The invention relates to a process for enriching the presence of H.pylori NAP  in a mixture or proteins, comprising the step of salting-out other proteins. NAP has been found to remain soluble at ammonium sulphate concentrations of 80 % and above. The process preferably comprises the further step of metal-chelate chromatography. The combination of salting-out and metal-chelate chromatography results in very pure NAP. The NAP preferably has the same sequence as NAP as naturally occurring in H.pylori and is free from sequences typically associated with recombinant protein production. The processes and NAP of the invention can be used in diagnostic and therapeutic products and processes.
PURPOSE: To obtain the subject composition excellent in stability, capable of substantially preventing coloration on the surface of tooth, comprising an antimicrobial dental plaque inhibitor causing coloration on the surface of tooth and an aminoguanidine as a coloration inhibitor compatible with the dental plaque inhibitor. CONSTITUTION: This antimicrobial composition for oral cavity comprises (A) a vehicle (e.g. aqueous solution of an alcohol) acceptable for oral cavity, (B) a cationic antimicrobial dental plaque inhibitor (e.g. chlorhexidine free base or its salt) having tendency to cause coloration on the surface of tooth or a long-chain tertiary amine antimicrobial dental plaque inhibitor (e.g. a tertiary amine containing two polyoxyethylene groups bonded to one aliphatic alkyl group and a nitrogen atom) and (C) an aminoguanidine free base capable of substantially preventing coloration on the surface of tooth, compatible with the component B or its water-soluble salt (e.g. aminoguanidine gluconate) at a ratio of 0.001-15wt.% of the component A, 0.01-10wt.% of the component B in the molar ratio of the components B:A of 0.2:1 to 6:1.
For each of the 9 renally impaired subjects a healthy control subject (as defined by a Clcr\>80mL/min matched to the severe subjects based on gender, ethnicity, body mass index (±15%) and age (±5 years)) will be recuited. They will receive FF/ GW642444M (200/25mcg) once daily for 7 days.
In this arm- 15 Patients with heart disease and hypercholesterolemia will receive standard statin treatment as determined by the Cardiologist. In addition, these patients will be on ezetimibe.
Patients receive usual care consisting of physical therapy once weekly, receiving pre-surgical information, instruction on the use of a spirometer device, and wearing a Fitbit to track activity. Patients then undergo video-assisted thoracic surgery or laparoscopic surgery. Patients continue to track activity using the Fitbit for 3 months post-surgery.
The occipital emissary foramen (OEF) located on the occipital bone transmits the occipital emissary vein, which connects the occipital vein to the confluence of cranial venous sinuses. The OEF varies in incidence, number, size, and location. Knowledge of this foramen is essential for carrying out suboccipital and transcondylar surgeries without clinical implications. Hence, the study was planned. The aim of the present study is to elaborate on incidence, location, and morphometry consisting of the number and size of this foramen in light of clinical bearing in the context of the Indian population. The study was carried out in the Department of Anatomy using 80 skulls of unknown age and sex. The occipital bone of the skull was observed for the incidence, number, size, and location of the occipital emissary vein and associated clinical implications were elaborated. The incidence of occipital foramen was 36.25% and detected in 29 skulls. All these occipital foramina were patent. The mean diameter of this foramen was 0.6 mm. The most common location of these foramina was the left side of the foramen magnum, followed by the left side of the external occipital crest. The information about the incidence, number, size, and location of OEF is important to prevent catastrophic bleeding during surgery in the region of the occipital bone. The awareness of differential morphometry and morphology of occipital foramina is of great importance for neurosurgeons during suboccipital craniotomy and skull base surgeries, including far lateral and transcondylar approaches to access posterior cranial fossa for management of pathologies in the cranial cavity.
PURPOSE: A pharmaceutical composition containing apigenin is provided to treat insomnia and dizziness. CONSTITUTION: A pharmaceutical composition for treating insomnia contains Cirsium japonicum extract as an active ingredient. The extract is crude extract or non-polar solvent soluble extract. The pharmaceutical composition for treating insomnia contains apigenin of chemical formula 1 as an active ingredient. Apigenin is isolated from Cirsium japonicum and induces deep sleep through interaction of GABA receptors and a GABAergic system. A health functional food for treating insomnia contains Cirsium japonicum extract or apigenin as an active ingredient. The health food is manufactured in the form of powder, granule, tablet, capsule, or beverage.
Single pulse electrical stimulation (SPES) is an investigational direct electrical stimulation (DES) pattern. Direct cortical stimulation applied at a frequency of ∼1Hz can probe cortico-cortical connections by averaging electrocorticogram time-lock to the stimuli.
A device 22 for forming a cellular network is provided comprising a substrate, on which a plurality of hydrophilic sites 16, for occupation by cells, and a plurality of hydrophilic tracks, 10, for guiding formation of cell connections between sites, are provided. Examples of materials used to make the hydrophilic zones are gold or aminoalkylsilane. Also provided are a plurality of hydrophobic regions 6A, between which the hydrophilic sites and tracks are recessed. The hydrophobic regions may be made of photoresist, teflon, PFTE, UV cured epoxy, alkylsilane or NI-35 protein from myelin. The hydrophilic sites may be provided with a guidance cue 24, for guiding formation of the network, preferably the guidance cue being an extracellular matrix (ECM) protein, collagen, laminin, polylysine. Methods of making the device are described and the neural network may be used in assaying their response to test compounds or electricity.
CBT randomized arm consists of participants who are randomized to the random condition and are randomized to receive cognitive-behavioral therapy (CBT). CBT consists of 10 weeks of weekly treatment.
This trial will compare it's subjects to subjects who have previously undergone MIPS for evacuation of ICH using the BrainPath access device as part of the ENRICH trial (NCT02880878). These subjects will be enrolled at an ENRICH trial site independent of our Institution. Deidentified patient information from 20 subjects in this group, who will be matched to those in the ENRICH-PLUS group, will be provided to the principal investigator for comparison of outcomes.
Gastrointestinal tract symptoms including nausea, vomiting, anorexia and abdominal pain have been associated with cysteamine, sometimes severe. In addition, gastrointestinal ulceration and bleeding have been reported in patients on cysteamine therapy. If these develop, therapy may have to be interrupted and the dose adjusted. A cysteamine dose of 1.95 grams/m2/day (approximately 80 to 90 mg/kg/day) was associated with an increased number of withdrawals from treatment due to intolerance and an increased incidence of adverse events.

Cysteamine has occasionally been associated with reversible leukopenia and abnormal liver function studies. Therefore, blood counts and liver function studies should be monitored.

There have been reports of benign intracranial hypertension (or pseudotumor cerebri; PTC) and/or papilledema associated with CYSTAGON® treatment that has resolved with the addition of diuretic therapy. PTC may be more common in cystinotic patients because of concurrent medication and renal transplantation. Although a causal relationship of PTC to CYSTAGON® has not been established, physicians should monitor patients receiving CYSTAGON® for this condition. Physicians should instruct patients to report any of the following symptoms: headache, tinnitus, dizziness, nausea, diplopia, blurry vision, loss of vision, pain behind the eye or pain with eye movement. A periodic eye examination is needed to identify this condition early and timely treatment should be provided when it occurs to prevent vision loss. 

There have been reports of serious skin lesions in patients treated with high doses of CYSTAGON® or other cysteamine salts that have responded to cysteamine dose reduction. These skin lesions are purplish hemorrhagic lesions over the elbow area on both arms and have been described as molluscoid pseudotumors. Skin striae, bone lesions (that have been described as osteopenia, compression fractures, scoliosis and genu valgum) along with leg pain and joint hyperextension may also be present. One patient with serious skin lesions subsequently died of acute cerebral ischemia with marked vasculopathy. Physicians should routinely monitor the skin and bones of patients receiving CYSTAGON®. If similar skin or bone abnormalities appear, the dose of CYSTAGON® should be reduced.
A wearable health monitoring device is disclosed and comprises a monitoring main body, a wearable component and a bio-characteristic monitoring module. The wearable component connects with the outside of the monitoring main body. The bio-characteristic monitoring module is disposed within the monitoring main body and comprises a photoelectric sensor, a pressure sensor and an air-pressure-based blood pressure meter. The air-pressure-based blood pressure meter is embedded and fixed in an embedding slot portion of an embedding seat, and the air-pressure-based blood pressure meter comprises a gas-gathering actuator and an elastic air bag. The gas-gathering actuator transmits gas to the elastic air bag. The elastic air bag can thereby be inflated and elastically protrude out from the monitoring main body, so that the elastic air bag can stick on a user's skin. The pressure sensor measures the vasoconstriction pulsation under the user's skin and generate a detection signal accordingly. The detection signal is then converted to a health data information and is outputted. The health data information is provided to the photoelectric sensor for calibrating the calculation of detection thereof to output a precise health data information.
Phase Ib: L-NMMA and docetaxel will be given for 6 21-day cycles. L-NMMA at doses of 10 mg/kg will be administered IV on Days 1-5. Docetaxel will be administered at 75 mg/m2 as an IV 15 min after L-NMMA infusion Day 1.
The present invention discloses a Chinese medicine suppository with functions of removing heat and toxic materials, arresting bleeding and promoting granulation, alleviating pain and diminishing swelling. Main medicine, auxiliary medicine and matrix are made into a semi-finished product, and the product is injected into a suppository mold so as to get the Chinese medicine suppository. The main medicine includes 66.7-200g Duangumo, 26.7-80g coptis, 50-150g corktree, 316.7-950g honeysuckle, 333.3-1000g forsythia  and 166.7-500g gynura segetum. The auxiliary medicine includes 166.7-500g hairyvein agrimony, 66.7-200g gromwell, 66.7-200g india madder root, 66.7-200g burnet root, 66.7-200g charred human hair  and 33.3-100g borneol. The share by weight of the matrix includes 80 4.83-14.5ml of Polysorbate, 19.38-58.15g Lanolin, 15.5-46.52g sorbitol-palmitate  and 258-774.20g semi-synthetic fatty acid glyceride. The share by weight of the nine Chinese medicine extracts is 252-756g; the share by weight of Duangumo charred human hair and borneol after ultramicro grinding is 166.7-500g, which is matched with the matrix and made into 333.3-1000 particles. The invented anal suppository has the advantages of direct curative effect to the sick part, rapid curative effect, standardized and stable process and full play to the curative effect.
Tubular structures, apparatuses, and methods for making tubular structures are disclosed herein. Walls of the tubular structures can include a hydrogel. A luminal material extends through the tubular wall. A cell population can live in the luminal material, the tubular wall, and/or on an outer surface of a tubular structure. Apparatuses for making tubular structures can include one or more inner extrusion nozzles removably positioned coaxially within one or more outer extrusion nozzles. The outer extrusion nozzle can be removably or permanently positioned within a housing of the apparatus, positioned above a column-shaped container. Methods of making a tubular structure can include coextruding a wall solution and a luminal solution into the column-shaped container and polymerizing the wall solution into a tubular structure. In some aspects, a light source can be configured to illuminate a light-permeable wall of the container or the nozzles for the purpose of polymerizing the wall solution.
Subjects aged between 6 months and 50 years at the time of enrolment living in geographically-defined communities in Latin America and Southeast Asia. The study population comprised household members and should include between 30% and 50% of adults (aged 18 years or above) per site.The appropriate recruitment strategy was selected by each participating site. Two approaches might be considered: a school-based approach and a community-based approach without school involvement The expected period for recruiting the target sample size was approximately three months.
Plants fully depend on their immune systems to defend against pathogens. Upon pathogen attack, plants not only activate immune responses at the infection site but also trigger a defense mechanism known as systemic acquired resistance (SAR) in distal systemic tissues to prevent subsequent infections by a broad-spectrum of pathogens. SAR is induced by mobile signals produced at the infection site. Accumulating evidence suggests that reactive oxygen species (ROS) play a central role in SAR signaling. ROS burst at the infection site is one of the earliest cellular responses following pathogen infection and can spread to systemic tissues through membrane-associated NADPH oxidase-dependent relay production of ROS. It is well known that ROS ignite redox signaling and, when in excess, cause oxidative stress, damaging cellular components. In this review, we summarize current knowledge on redox regulation of several SAR signaling components. We discuss the ROS amplification loop in systemic tissues involving multiple SAR mobile signals. Moreover, we highlight the essential role of oxidative stress in generating SAR signals including azelaic acid and extracellular NAD(P) [eNAD(P)]. Finally, we propose that eNAD(P) is a damage-associated molecular pattern serving as a converging point of SAR mobile signals in systemic tissues.