anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
The survey included questions addressing the following areas: 1.) Information that is important to know when learning to manage Nephrotic Syndrome. 2.) Preferred resources for the education of patients and caregivers with newly-diagnosed Nephrotic Syndrome. 3.) The time frame required to acquire confidence in the management of Nephrotic Syndrome. 4.) Disease-specific information such as diagnosis, length of disease duration, medications used, need for kidney biopsy, dialysis and/or transplant. 5.) Demographic data such as race/ethnicity and educational background.

The survey data is stored by the Rare Diseases Clinical Research Network's Data Management and Coordinating Center (DMCC) at the University of South Florida. The data is de-identified. Names or other personal health information were not collected. Upon conclusion of the study period, the data will be sent to the NEPTUNE consortium lead at the University of Michigan.
FIELD: cosmetic industry. SUBSTANCE: invention relates to the soap production, in part, to solid detergent compositions exhibiting the pediculicide effect. Pediculicide soap has palm and coconut oil fatty acid sodium salts, antioxidant, permethrin, vegetable oils or mink fat or palm oil fatty acids and water. Components are taken at definite quantitative ratios. EFFECT: stability, resistant pediculicide effect of soap, safety in using. 1 cl, 4 ex
Neurodegenerative diseases, like Alzheimer's, are associated with the presence of neurofibrillary lesions formed by tau protein filaments in the cerebral cortex. While it is known that different morphologies of tau filaments characterize different neurodegenerative diseases, there are few metrics of global and local structure complexity that enable to quantify their structural diversity rigorously. In this manuscript, we employ for the first time mathematical topology and geometry to classify neurodegenerative diseases by using cryo-electron microscopy structures of tau filaments that are available in the Protein Data Bank. By employing mathematical topology metrics (Gauss linking integral, writhe and second Vassiliev measure) we achieve a consistent, but more refined classification of tauopathies, than what was previously observed through visual inspection. Our results reveal a hierarchy of classification from global to local topology and geometry characteristics. In particular, we find that tauopathies can be classified with respect to the handedness of their global conformations and the handedness of the relative orientations of their repeats. Progressive supranuclear palsy is identified as an outlier, with a more complex structure than the rest, reflected by a small, but observable knotoid structure (a diagrammatic structure representing non-trivial topology). This topological characteristic can be attributed to a pattern in the beginning of the R3 repeat that is present in all tauopathies but at different extent. Moreover, by comparing single filament to paired filament structures within tauopathies we find a consistent change in the side-chain orientations with respect to the alpha carbon atoms at the area of interaction.
PROBLEM TO BE SOLVED: To provide a new compound produced by culturing a microorganism belonging to the genus Streptomyces and capable of producing a new compound A-74259, having remarkable glucosidase inhibiting action and useful as an antiviral agent, an anti-AIDS agent, an antitumor agent, etc. SOLUTION: The objective new compound A-74259 is expressed by the formula, exhibits a white powdery state, has a molecular formula of C7 H12 O6 (determined by high-resolution mass-spectrum), a molecular weight of 192 (determined by FAB-MS spectrum) and a specific rotation of [α]D<25> =+70 deg. (c=0.8, 25 deg.C, in H2 O) and is soluble in dimethyl sulfoxide, water and methanol and insoluble in ethyl acetate and chloroform. It has remarkable α-glucosidase inhibiting activity and is useful as an antiviral agent, an anti-AIDS agent, an antitumor agent, etc. The new compound can be produced by culturing a microbial strain belonging to the genus Streptomyces and capable of producing the new compound A-74259 (e.g. Streptomyces sp. SANK 62695) and separating the produced compound from the cultured product.
Potato late blight is the most devastating pre- and post-harvest crop disease in the world, which is widespread and difficult to control, causing serious economic losses. Cultivating resistant varieties is a major way to prevent and control late blight in a green way. However, due to the rapid evolution of pathogens, the plant resistance is losing. Therefore, mining effective and durable genes involved in disease resistance is crucial for breeding resistant varieties against late blight. In this study, we took "potato-Phytophthora infestans" as the "host-pathogen" model system to discover the potential disease resistance-related genes and elucidate their molecular functional mechanism. Through yeast two-hybridization, bimolecular fluorescence complementation, Co-immunoprecipitation assays, and gene function validation etc., we found that ribosomal protein S6 kinase 2 (StS6K2) is a key resistant protein, which is interacted with StWRKY59 transcription factor. Overexpression of StS6K2 and StWRKY59 both enhanced the plants resistance to P. infestans, and promoted the host immune response, such as ROS burst and callose deposition. In OEStWRKY59 lines, DEGs involved in secondary metabolites synthesis, plant hormone signaling transduction and plant-pathogen interaction were significantly enriched. These findings provide novel genetic resources for the breeding of resistant varieties.
PURPOSE: Growing rods are the gold-standard for treatment of early onset scoliosis (EOS). However, these implanted rods experience frequent fractures, requiring additional surgery. A recent study by the U.S. Food and Drug Administration (FDA) identified four common rod fracture locations. Leveraging this data, Agarwal et al. were able to correlate these fractures to high-stress regions using a novel finite element analysis (FEA) framework for one patient. The current study aims to further validate this framework through FEA modeling extended to multiple patients.
METHODS: Three patient-specific FEA models were developed to match the pre-operative patient data taken from both registry and biplanar radiographs. The surgical procedure was then simulated to match the post-operative deformity. Body weight and flexion bending (1 Nm) loads were then applied and the output stress data on the rods were analyzed.
RESULTS: Radiographic data showed fracture locations at the mid-construct, adjacent to the distal and tandem connector across the patients. Stress analysis from the FEA showed these failure locations matched local high-stress regions for all fractures observed. These results qualitatively validate the efficacy of the FEA framework by showing a decent correlation between localized high-stress regions and the actual fracture sites in the patients.
CONCLUSIONS: This patient-specific, in-silico framework has huge potential to be used as a surgical tool to predict sites prone to fracture in growing rod implants. This prospective information would therefore be vital for surgical planning, besides helping optimize implant design for reducing rod failures.
The embryonic chicken is a valuable model for studying the maturation of cardiovascular physiology and the responses of this organ system to environmental manipulations such as acute hypoxia. Hypoxia determines not only the general cardiovascular response but also is a tool to determine the system's maturation of reflexive control. Several studies suggest embryonic chicken's regulation of the cardiovascular response to hypoxia, but no studies have measured the blood chemistry changes that accompany these responses. To clarify the changes in blood parameters accompanying cardiovascular function changes during acute hypoxia, we designed a study to investigate the blood chemistry (pO2, pCO2, pH, lactate, glucose, and blood ions) in developing embryos during acute hypoxia (O2 = 10 %). Embryos ranging from day 13 to 21 of incubation were sampled during a control period and at the end of a 5-min of hypoxia. Hypoxia caused bradycardia on all days of incubation. The maximal blood hypoxic response occurred on day 15, with lactate increasing 7-fold (2.5 to 16.6 mmol/l) while glucose levels decreased by 50 % (136 to 63 mg/dl). Furthermore, hypoxia reduced pH (7.40 to 7.26), which peaked on day 15. These data indicate that a 5-min exposure to 10 % O2 is sufficient to induce dramatic changes in blood chemistry however chorioallantoic arterial blood pO2 was unchanged on most days of the study. Therefore, given the cardiovascular response to hypoxia and the increase in blood lactate prior to airbreathing in the chicken embryo, the embryonic tissues experienced an acute stress that may be the basis for the change in cardiovascular function during the exposure.
DT-I is a quasidesensitization treatment presented as a means of eliminating the "conditioned arousal," which prolongs nocturnal awakenings. DT-I has been validated as an active-placebo control condition. Therapists help each DT-I recipient develop a chronological 12-item hierarchy of common activities he/she does on awakening at night (e.g., opening eyes, clock watching). Therapists also help them develop 6 imaginal scenes of themselves engaged in neutral activities (e.g., reading the newspaper). Each session, DT-I recipients are taught to pair neutral scenes with items on the 12-item hierarchy so, by the end of the sixth session, all hierarchy items have been practiced with therapist assistance. Each session, the exercise is tape recorded and the patient is given this tape locked in a player. The patients are told to practice their exercises at home once each day, no less than 2 hours before bedtime, but to avoid using the tape or exercise during sleep periods.
PURPOSE: A stick for whitening tooth surfaces containing tooth whitening substance in a solid stick which is in the form of O/W, W/O, W/O/W and O/W/O is provided. It can be selectively applied to a desired tooth without falling down during coating and foreign body sensation. CONSTITUTION: The stick for whitening tooth surfaces comprises: a tooth whitening substance selected from peroxides, a chlorine-based bleaching agent, a polyphosphate, vitamin E, enzyme and sodium bicarbonate; and titanium dioxide, hydroxy apatite, titanated mica or pigments of various colors. The stick has a hardness of 40 to 150 and is made using an emulsion system. The peroxides are selected from hydrogen peroxide, urea peroxide, sodium carbonate peroxide, sodium perborate, calcium peroxide and sodium pyrophosphate peroxide. The emulsion system is O/W, W/O, W/O/W and O/W/O.
PROBLEM TO BE SOLVED: To provide a liquid hair treatment agent capable of suppressing hair-hitching due to deterioration in finger-combing and combing.SOLUTION: The liquid hair treatment agent of the present invention is a liquid hair treatment agent compounded with a hydrolysis protein and an anionic compound. The anionic compound is preferably at least one of anionic surfactants and dilauroyl glutamic acid lysine salts. The viscosity of the liquid hair treatment agent is, for example, 100 mPa s or less. The compounded amount of the anionic compound is preferably 1 mass% or less. The compounded amount of the hydrolysis protein is, for example, 10 mass% or less. The liquid hair treatment agent is preferably further compounded with water. The compounded amount of the water is, for example, 85 mass% or more.
Phytus (Cisti, thyme and Ivy leaves) given to patients on day 1 and day 4. On 4th day, night and day cough score along with adverse event will be assessed. Sponsor will bear the treatment cost during the study time period.
Pre-school children and residential seniors will receive two weekly exercise training sessions lasting 45 minutes each. All exercise training sessions are conducted by professional exercise coaches and are planned in a progressive and variable manner. The training sessions focus on balance and fundamental movement skills.
The invention discloses a tryptophan and tryptophan cross-chain interaction beta-hairpin antibacterial peptide, a preparation method and application thereof, and belongs to the field of bioengineering. The sequence of the antibacterial peptide WWL is shown as SEQ ID No. 1. The preparation method comprises the following steps: the antibacterial peptide template XWRYRPGRWRYX-NH  2  is obtained by stabilizing a beta-hairpin structure through interaction between a pair of cross chains formed by tryptophan and tryptophan by taking PG as a corner unit, wherein X is hydrophobic amino acid, Y is tryptophan, and when X=L, Y=W, the antibacterial peptide is named as WWL. The antibacterial peptide disclosed by the invention not only maintains better stability, but also reduces the toxicity of the antibacterial peptide on the premise of replacing disulfide bonds, and the survival rate of the pig small intestine epithelial cells reaches more than 90% under all detection concentrations. On the premise of keeping good antibacterial activity, no hemolysis phenomenon is found in the detection range, and the therapeutic index is as high as 95.52. In conclusion, the antibacterial peptide WWL has higher application value.
BACKGROUND: The myostatin gene has played an important role in the genetic improvement of the main species of economic importance; however, it has not yet been described for some Neotropical fish essential for aquaculture. This study aimed to characterize the myostatin gene of pacu, Piaractus mesopotamicus, and investigate the association of a microsatellite marker in this gene with the weight of fish.
METHODS AND RESULTS: The myostatin gene sequence was obtained after following a RACE-PCR strategy based on a partial mRNA sequence available in the GenBank database and the alignment of myostatin sequences from other fish species. The obtained sequence for the P. mesopotamicus gene was analyzed for short tandem repeats, and one dinucleotide was observed at the 3´untranslated region. A short tandem repeat polymorphism was verified in a wild population. Subsequently, the STR was evaluated in a test population of 232 animals in two 220 m² concrete tanks at the Aquaculture Center of Unesp. Eight alleles and 22 genotype combinations were identified. A significant association was observed between microsatellite marker polymorphisms and the weight traits (WEIGHT1 and WEIGHT2). Alleles 210, 222, 226, and 230 were found to favor weight gain.
CONCLUSIONS: In summary, this study contributes to the characterization of the myostatin gene in pacu fish and identifies an association between a STR and weight traits. Thus, this gene could be used as a target for genetic breeding using molecular strategies such as CRISPR and quantitative strategies such as marker-assisted selection, which would contribute to improving the production of the species.
Disclosed herein are platforms, systems, software, and methods for evaluating social behavior. Speech or audio data can be analyzed to identify elemental language and acoustic components of speech that are used to determine higher order effects such as social behavior. Disclosed herein are models developed to address the assessment of mental health status (e.g. diagnosis and assessment of neurocognition and symptom ratings). In some embodiments, disclosed herein are models configured to predict performance on social and functional competency assessments. The present disclosure demonstrates the ability of a set of language features to provide several relevant upstream and/or downstream clinical assessments on audio derived data such as transcripts that were never seen during model training and showed consistent performance on all tasks of interest.
PURPOSE: A composition containing Phellinus linteus hot water extract is provided to reduce oxidative stress, to suppress neural cell apoptosis, and to prevent alcoholic brain diseases. CONSTITUTION: A composition for preventing or treating alcoholic brain diseases contains Phellinus linteus hot water extract as an active ingredient. The hot water extract suppresses neural cell death. The composition contains 10-300 ug/ml of the hot water extract. The alcohol is ethanol. A health functional food for relieving hangover contains the hot water extract.
Trabectedin will be delivered by infusion on day 1 followed by 2 doses on irinotecan delivered by infusion for one hour on day 2 and day 4 of 21 day cycles. Some patients will receive an 18F-FLT Imaging scan prior to the first administration of trabectedin and once after administration of trabectedin.
Pain is a multidimensional experience that includes sensory, cognitive, emotional, and social factors. The International Association for the Study of Pain defines chronic pain as pain that lasts longer than three months, besides the lack of a clear description. Chronic pain is a critical developmental health issue that can be recurring or persistent, causing significant disruption in everyday life. Children with chronic pain that is continuous or recurrent may be unable to attend school, may withdraw from social activities, and may develop internalizing symptoms as a result of their discomfort. Given these findings, researchers and clinicians must focus on concerns connected to pediatric chronic pain in order to reduce these challenges and develop appropriate methods. Adults are reported to suffer from 19 percent of chronic pain, with two-thirds describing their pain as "persistent" and 50% describing it as "unbearable." Chronic pain has emerged as a significant problem in children, affecting around one out of every four children, while approximately 3% of children require intense pain therapy.

Psychosocial factors interact with physiological processes to influence pain outcomes such as pain perception and impairment, according to the biopsychosocial model of chronic pain. Fear of pain is a psychological mechanism that has been shown to be effective in predicting chronic pain and accompanying disability in adults. When pain-related sensations are viewed as dangerous, fear of pain develops. The Fear Avoidance Model of Pain outlines how fear of pain influences the outcomes of people who are in chronic pain. Many elements of the condition, including experimentally generated pain severity, pain during dental treatment, chronic pain behavior, and pain-related disability, have been linked to fear of pain. Simultaneously, in the Fear Avoidance Model of Pain, if pain is seen as threatening, pain-related fear develops, leading to avoidance. Simultaneously, in the Fear Avoidance Model of Pain, if pain is seen as threatening, pain-related fear develops, leading to avoidance behaviors and hypervigilance. After that, there's incapacity and depression. These negative outcomes aggravate the fear and avoidance loop. While assessing fear of pain is critical, assessing fear of re-injury is more difficult because it can entail movement, physical activity, or a mix of these things. Furthermore, patients frequently do not report or subjectively sense pain, but rather have trouble performing the actions or activities that have been required of them.

In the adult literature, various scales have been established to assess fear of pain. Fear of pain has been shown to have a role in adult chronic pain research, but it has gotten less attention in pediatric chronic pain research. The Fear of Pain Questionnaire for children and parents (FOPQ-C SF, FOPQ-P) is a questionnaire that addresses this knowledge gap. As a result, the purpose of this study is to see if the Fear of Pain Questionnaire for Children \& Parents (FOPQ-C, FOPQ-P) Scale is valid in the Turkish community and how effective it is in therapeutic practice.
Patients were treated with topical placebo for 1 hour, twice per day. The dosage was the same as the topical tripterygium group.
The original case-control study was planned to investigate the link of solar radiation with gene damage, host factors, including also genetic variants, and DNA repair proficiency in cutaneous malignant melanoma (CMM) risk, in subjects from the Mediterranean area, characterized by a wide range of pigmentary characteristics and intense sun exposure. This study was reviewed and funded as an R01 grant from the National Cancer Institute in 1995. Subject enrollment, which included clinical evaluation, epidemiologic questionnaires, and skin and blood sample collection, was completed in 1999 on approximately 180 melanoma cases and 180 controls identified in Italy. The study protocol and consent form both included the measurement of genetic and biochemical factors, and DNA repair capacity. DNA repair proficiency was measured in lymphocytes by the host cell reactiviation assay, and sun exposure was evaluated by means of a detailed questionnaire. Minimal erythemal dosage was measured in all subjects to estimate skin sun sensitivity 24 hours after skin's UVirradiation. Skin color was ascertained on the inner side of the forearm by means of a minolta chromometer.

The aim of this protocol was to continue the analysis of the biological samples and data already collected, as originally outlined in the study protocol. However, the original sample size was small and precluded specific analyses of gene-environment interaction crucial for the understanding of the etiology of melanoma. We have identified other collaborators willing to share their data and sample with us to increase the power for statistical analyses. We obtained approval (amendments to 02-C-N035 approved in November 2006, September 2008, December 2010, and June 2011) to use the DNA samples and data collected in four studies conducted by investigators at the University of L'Aquila, Italy, University of Genoa, Italy, Istituto Valenciano de Oncologia, Valencia, Spain, and the New York University School of Medicine, respectively. We have obtained approval with stipulations in August 2014 to also include samples and data collected from the Papa Giovanni XXII Hospital in Bergamo, Italy and the University of Athens, Greece. We are now responding to the stipulations and asking to further include samples from the University of Padua and the Hospital Clinic of Barcelona within the same study.

We are currently analyzing genes in several pathways, including pigmentation, DNA repair, immune-related functions and those involved in the transition from nevi to melanoma (genes in the cell cycle, telomere, signaling pathways, etc). With the additional samples we plan to conduct a GWAS analysis of melanoma in Mediterranean countries and a molecular analysis of melanoma tissue lesions for an improved classification of the disease and its association with melanoma progression.
Intravenous methylprednisolone bolus of 10mg/kg on day1, 2 and 3, then 1mg/kg/d for 1 week, and 0,75 mg/kg/d for 1 week, then 0,5 mg/kg/d for 1 week, and 0,25 mg/kg/d for 1 week, and 0,125 mg/kg/d until day 90. Shift to oral prednisone as soon as the oral route is available.
PROBLEM TO BE SOLVED: To obtain the subject pharmaceutical preparation, capable of improving even bronchi-related symptoms, essentially free of side effect, low in toxicity and safe by including ingredients of hatimi-ziogan, and fruit of Schizandra chinensis and Ophiopogon Tuber. SOLUTION: This pharmaceutical preparation contains, as the active ingredient, a concentrated product containing Schizandra chinensis and Ophiopogon Tuber which are included in hatimi-ziogan composed of rehmanniae radix, cornus fruit, Dioscorea rhizome, Alisma rhizome, Hoelen, Moutan Bark, cassia bark, and aconiti tuber. It can be made into tablets or fine granules by an excipient. It is preferable to include rehmanniae radix, cornus fruit, Dioscorea rhizome, Alisma rhizome, Hoelen, Moutan Bark, cassia bark, processed aconiti tuber, Schizandra chinensis and Ophiopogon Tuber in the ratio of 5:3:3:3:3:3:1:1:2:3.  This composition allows these ingredients to exhibit positive interactions for notably improving the bronchi-related symptoms in addition to the symptoms of low back pain, difficulty of urination and feebleness, while exhibiting essentially no negative interactions, e.g. side effects.