anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: Active smoking is a well-established risk factor for developing Crohn's disease (CD) and negatively impacts overall disease progression. Patients who start or continue smoking after CD diagnosis are at risk for poor outcomes, higher therapeutic requirements, and have higher rates of relapse. However, it remains unclear if the exposure to smoking leads to increased sequencing through treatment therapies, especially biologics.
METHODS: The Study of Prospective Adult Research Cohort with IBD (SPARC IBD) registry has been collecting patient-reported outcomes data in real-time, as well as laboratory, endoscopic, and pathologic samples from 17 tertiary referral centers since 2016. In this study, we conducted a retrospective review of the SPARC clinical registry collected between December 2016 and January 2021 from 1 participating site, the University of Maryland School of Medicine's Inflammatory Bowel Disease Program. A total of 619 patients were enrolled in the SPARC IBD database. Four hundred twenty-five patients with CD were included for initial review of completeness of data; of these, 144 patients were excluded due to missing data on smoking status and/or biologic treatment, resulting in a final cohort of 281 patients. We collected and analyzed baseline demographic and clinical characteristics. The final cohort was categorized into 3 exposure groups: current, former, and never smokers. Our outcome of interest was number biologics used, categorized into 3 groups: 0, 1, or ≥2 biologics.
RESULTS: One hundred seventy-two never smokers, 70 former smokers, and 39 current smokers were identified. Current, former, and never smokers had no statistically significant differences in number of biologics used (ie, biologic sequencing). However, statistically significant independent risk factors for increased sequencing of biologics were identified. These risk factors included female sex, ileocolonic disease location, younger age at diagnosis, and prolonged disease duration; none of these factors remained significant in adjusted analyses.
CONCLUSION: To date, this is the first study assessing the association of smoking and sequencing of biologics. Although current or former smokers were not found to sequence through more biologics when compared with never smokers, smoking is a well-established risk factor for poor health outcomes, and efforts should be made to counsel patients to quit. Further, additional research must be done to stratify risk to patients based on amount of tobacco exposure.
Following a 10-hour overnight fast, subjects will be administered one dose of SHR1459 orally with 240 mL of ambient temperature water on Day 1. D2-D3 was the cleaning period. Itraconazole will be administered orally 200 mg/time/day form D4 to D8 after meal. On D7 following a 10-hour overnight fast, subjects will be administered SHR1459 and itraconazole 200 mg with 240 mL of ambient temperature water.
To support guidance to improve lifestyle for a medical examinee.SOLUTION: A medical information processing apparatus according to an embodiment comprises: an acquisition unit; a setting unit; an extraction unit; a classification unit; and an output unit. The acquisition unit acquires medical data in which the state of the body of a medical examinee and the history of lifestyle of the medical examinee are recorded. The setting unit sets the name of the medical examinee's disease. The extraction unit extracts, from the medical data of the other medical examinee in which information on the onset or suspected onset of the name of a disease is recorded, medical data similar to the data characteristics of the medical data acquired by the acquisition unit. The classification unit classifies the medical data extracted by the extraction unit for every group similar in data characteristics. The output unit outputs information representing the relationship between the state of the body and the lifestyle based on the medical data belonging to the groups.SELECTED DRAWING: Figure 5
All patients received preoperative long-term concurrent chemoradiotherapy: radiotherapy for five weeks, five days a week (pelvic 2 Gy/ time, GT50 Gy), during which capecitabine (1650mg/m2/ day, orally divided twice). Intensity modulated radiotherapy was used. CT and rectal MRI were evaluated again 8-12 weeks after radiotherapy, followed by radical resection of rectal cancer plus LLND (unilateral or bilateral LLND was performed according to LLN metastasis before treatment).
In these seven communities, we plan to perform monitoring visits at 12 months and 24 months, in order to assess clinically active trachoma, ocular chlamydia infection, nasopharyngeal macrolide resistance, soil transmitted helminths, and childhood growth (height and weight). We will also perform assessments of the adequacy of the intervention, by conducting household surveys to assess hygiene behavior, access to water and latrines, and fly density.
A pharmaceutical compsn. contg. isoboride dinitride (I) for oral admin. for acute and long-term treatment of angina pectoris, characterised in that a core consisting of (I) and a surrounding signal layer of a physiologically acceptable carrier material, is coated with (I)-contg. layer, alone or in combination with suitable inerting agents in a polymer soln. or other additives for fixing the active agent. Pref. the core comprises 20-120mg (I). The signal layer comprises an acid (esp citric acid) and a binder. The polymer soln. comprises polyvinylpyrrolidone, polyvinyl alcohol, methylcellulose, hydroxypropylmethylcellulose, hydroxypropylcellulose and/or polyethylene glycol. ADVANTAGE - The object of the invention is to provide a dosage form for (I) that prevents or stops an angina attack and also maintains long-lasting plamsa levels of (I).
FIELD: medicine. ^ SUBSTANCE: invention concerns area of medicine and concerns therapeutic and preventive vaccines against hepatitis B and HIV. The essence of the invention: the offered composition includes a superficial antigen of hepatitis B (HBsAg) as the main component, received as a recombinant product of Pichia pastoris and the vaccine antigen representing polypeptide CR3, containing epitopic determinants of a human immunodeficiency virus. The offered composition can be applied at HIV treatment and during too time as a preventive vaccine against the virus of hepatitis B. ^ EFFECT: working out of a composition which can be applied at treatment HIV and during too time as a preventive vaccine against the virus of hepatitis B. ^ 3 cl, 5 dwg, 7 ex
In recent years, the importance of isolating single cells from blood circulation for several applications, such as non-invasive tumour diagnosis, the monitoring of minimal residual disease, and the analysis of circulating fetal cells for prenatal diagnosis, urged the need to set up innovative methods. For such applications, different methods were developed. All show some weaknesses, especially a limited sensitivity, and specificity. Here we present a new method for isolating a single or a limited number of cells adhered to SBS slides (Tethis S.p.a.) (a glass slide coated with Nanostructured Titanium Dioxide) by Laser Capture Microdissection (LCM) and subsequent Whole Genome Amplification. SBS slides have been shown to have an optimal performance in immobilizing circulating tumour cells (CTCs) from early breast cancer patients. In this work, we spiked cancer cells in blood samples to mimic CTCs. By defining laser parameters to cut intact samples, we were able to isolate genetically intact single cells. We demonstrate that SBS slides are optimally suited for isolating cells using LCM and that this method provides high-quality DNA, ideal for gene-specific assays such as PCR and Sanger sequencing for mutation analysis.
FIELD: medicinal virology. SUBSTANCE: method involves the use of triazide - (25S)-5α=3β, 22a, 26-triol-26-O-b-D-glucopyranoside (tomatoendo) at final concentration 0.005% and above for inactivation of rotaviruses. Inactivation is carried out by addition of tomatoside solution at indicated concentration to virus-containing material. Then mixture is kept at the room temperature for 1 hr and more. Manifestation of antiviral agent effect is detected by infectivity virus assay on the cultured cells. EFFECT: enhanced inactivation of viruses. 3 tbl
A portable remote ultrasound scanning system is disclosed. A master device includes a handheld device and a master computer. A slave device includes a slave scanning robot, a slave ultrasound device, a slave environment sensing unit, and a data transceiver unit. The handheld device is configured to send velocity information of a movement of the handheld device, angular velocity information of a rotation of the handheld device, and a pressing force to a controller of the slave scanning robot through the master computer and the data transceiver unit. The controller is configured to control a movement of the robotic arm in a horizontal plane, an orientation movement of the robotic arm in space, and a movement of the robotic arm along a normal direction of a scanning surface. The master computer displays an ultrasound scanning image. An entire movement process of the robotic arm is performed through a compliance control.
This is a randomized (the study medication is assigned by chance), double-blind (neither physician nor participant knows the identity of the assigned treatment), placebo-controlled (an inactive substance that is compared with a medication to test whether the medication has a real effect in a clinical study), single-ascending (increasing) dose and multiple-ascending dose study of JNJ-42721458 compound in healthy males. The study is divided in two parts. Part 1 is a single-ascending dose (SAD) study which will include up to 10 panels (using ascending doses starting from 0.1 mg) in which a single dose of the study medication will be administered on Day 1. Part 2 is a multiple-ascending dose (MAD) study which will include approximately 6 panels (using ascending doses starting from 5.0 mg) in which multiple doses of study medication will be administered once daily for 10 days.

Part 2 will be initiated after completion of dosing and all relevant evaluations from Part 1. In each panel of Part 1 and 2, 6 participants will be randomly assigned to receive JNJ-42721458 and 2 participants randomly assigned to placebo. Safety evaluations will include assessment of adverse events, physical examinations, laboratory tests, vital signs, electrocardiograms, cardiac telemetry and evaluation of injection sites which will be monitored throughout the study. The total study duration for each participant will be approximately 6-7 weeks in Part 1 and 7-8 weeks for each participant in Part 2.
This study aims to identify potential correlations of the severity of symptoms of children with autism spectrum disorder (ASD) with serum nutritional levels, body composition indicators, diet partiality, and sleep disturbances. The cohort of this cross-sectional study included 120 children with ASD and 110 typically developing (TD) children to assess symptoms of ASD, and to measure serum levels of vitamins and minerals and the body composition values. Diet partiality and sleep disturbances were assessed by administering questionnaires. The serum levels of folic acid, copper, and vitamin B were lower in children with ASD than in TD children, while magnesium and homocysteine were higher (p < 0.05). Children with ASD had greater chest circumference, abdominal skinfold thickness, and body mass index (BMI) than TD children (p < 0.05), and higher prevalences of diet partiality and sleep disturbances (p < 0.001). Lower vitamin A levels and higher vitamin D levels were related to social impairment in children with ASD. Moreover, there were significantly positive correlations of BMI, chest circumference, diet partiality, and sleep disturbances with severity of ASD symptoms (p < 0.05). Collectively, rational nutritional supplementation, dietary management, and behavioral interventions are essential for children with ASD.
The present invention relates to a new HPLC method for the analysis of the drug substance frovatriptan and related substances. In particular, the present invention relates to a new HPLC method for the analysis of the drug substance frovatriptan monosuccinate monohydrate and related substances. In a first method the mobile phase comprises two or more liquids and the relative concentration of the liquids is varied to a predetermined gradient. In other methods the stationary phase is reverse phase and the mobile phase comprises an alcohol and/or an alkylamine. In yet another method the mobile phase comprises a formate salt. A final method comprises the detection and optional quantification of specific impurities. The present invention also relates to frovatriptan and associated pharmaceutical compositions from which samples have been analysed by the methods of the invention and/ or which are substantially free of specific impurities.
A method for enhancing the overall beneficial immune system response in a host that works in conjunction with the host's natural immune system response to simultaneously enhance the host's ability to eliminate infectious microbes while suppressing the toxicity of the immune system response to the host. The method utilizes the non-enzymatic formation of allicin in response to the localized generation of H2O2 by immune system cells (such as neutrophils) to simultaneously increase the antimicrobial effect while reducing the cytotoxicity to the host. It is shown that enzymes can be reversibly inhibited that would not normally be sensitive to deactivation by a thiol-disulfide exchange reaction. This results in part from the recognition that deactivation of SH dependant enzymes by allicin does not take place by the previously attributed mechanism of thiol-disulfide exchange reactions. Allicin, cysteine, and related organosulfur compounds have a variety of antimicrobial and immunomodulatory properties that work together with the host's immune system in the prevention and treatment of disease. Prophylactic and therapeutic treatment is provided by administering an allium-related organosulfur compound such that a localized thiosulfinate is caused to be non-enzymatically formed in response to localized generation of H2O2 by the activated immune system cells. Allicin, cysteine and related organosulfur compounds may be simultaneously delivered in an efficient manner through the use of protein-bound S-AllylMercaptoCysteine (SAMC) or similar prodrugs.
A system and method for profiling electrical activity in smooth muscle of the gastrointestinal tract muscular of a patient are disclosed. The system includes electromyographic-sensing patches adapted for placement on the skin of the abdomen of the patient. Each patch has at least one bipolar electrode pair, or a multitude arranged in an array, and is enabled for communication of a signal indicative of a sensed electromyographic signal. The system further includes networked computing devices. The local patch device is configured for wireless communication between the EMG-sensing patches and a local computing device, to enable wireless transmission from the patch to the networked computing devices. The networked computing device is configured to process large aggregate collections of multi-hour or day signals received from the local computing device to yield diagnostically valuable physiological parameters of gastrointestinal smooth muscle electrical activity.
The present invention relates to providing molecular data based on CT images. The invention is based on a computer-implemented method for providing molecular data. The method includes receiving a computed tomography image of at least a portion of a lung of a patient, wherein the computed tomography image depicts at least one lung nodule. Molecular data is determined by processing the first input data with a first trained function, wherein the first input data is based on a computed tomography image, and wherein the molecular data is related to biomarkers within a genome of the patient, a transcriptome of the patient, a proteome of the patient, and/or a metabolome of the patient. In addition, molecular data is provided. Providing the molecular data may include displaying, transmitting, and/or storing the molecular data.
The technology disclosed relates to systems and methods for predicting digital twins. The system includes logic to use a machine learning model predict correlation between pairs of persons and save the results in an environmental and phenotypic correlation matrix. The inputs to the machine learning model can include data from individual-level and group-level datasets. The individual-level datasets include administration dataset including clinical data and person dataset including personal data. The group-level datasets include exposome dataset including environmental exposure and subpopulation dataset. The system includes logic to use the environmental and phenotypic correlation matrix as a random effect when determining associations between exposures and outcomes. The system includes a second machine learning model that can take a pair of exposure and outcome and the environmental and phenotypic correlation matrix as input to predict causal association between exposure and outcome.
Inner Mongolia cashmere goat is an excellent livestock breed formed through long-term natural selection and artificial breeding, and is currently a world-class dual-purpose breed producing cashmere and meat. Multi trait animal model is considered to significantly improve the accuracy of genetic evaluation in livestock and poultry, enabling indirect selection between traits. In this study, the pedigree, genotype, environment, and phenotypic records of early growth traits of Inner Mongolia cashmere goats were used to build multi trait animal model., Then three methods including ABLUP, GBLUP, and ssGBLUP wereused to estimate the genetic parameters and genomic breeding values of early growth traits (birth weight, weaning weight, average daily weight gain before weaning, and yearling weight). The accuracy and reliability of genomic estimated breeding value are further evaluated using the five fold cross validation method. The results showed that the heritability of birth weight estimated by three methods was 0.13-0.15, the heritability of weaning weight was 0.13-0.20, heritability of daily weight gain before weaning was 0.11-0.14, and the heritability of yearling weight was 0.09-0.14, all of which belonged to moderate to low heritability. There is a strong positive genetic correlation between weaning weight and daily weight gain before weaning, daily weight gain before weaning and yearling weight, with correlation coefficients of 0.77-0.79 and 0.56-0.67, respectively. The same pattern was found in phenotype correlation among traits. The accuracy of the estimated breeding values by ABLUP, GBLUP, and ssGBLUP methods for birth weight is 0.5047, 0.6694, and 0.7156, respectively; the weaning weight is 0.6207, 0.6456, and 0.7254, respectively; the daily weight gain before weaning was 0.6110, 0.6855, and 0.7357 respectively; and the yearling weight was 0.6209, 0.7155, and 0.7756, respectively. In summary, the early growth traits of Inner Mongolia cashmere goats belong to moderate to low heritability, and the speed of genetic improvement is relatively slow. The genetic improvement of other growth traits can be achieved through the selection of weaning weight. The ssGBLUP method has the highest accuracy and reliability in estimating genomic breeding value of early growth traits in Inner Mongolia cashmere goats, and is significantly higher than that from ABLUP method, indicating that it is the best method for genomic breeding of early growth weight in Inner Mongolia cashmere goats.
Pancreatic ductal adenocarcinoma (PDAC) poses significant clinical challenges, often presenting as unresectable with limited biopsy options. Here, we show that circulating tumor cells (CTCs) offer a promising alternative, serving as a "liquid biopsy" that enables the generation of in vitro 3D models and highly aggressive in vivo models for functional and molecular studies in advanced PDAC. Within the retrieved CTC pool (median 65 CTCs/5 mL), we identify a subset (median content 8.9%) of CXCR4+ CTCs displaying heightened stemness and metabolic traits, reminiscent of circulating cancer stem cells. Through comprehensive analysis, we elucidate the importance of CTC-derived models for identifying potential targets and guiding treatment strategies. Screening of stemness-targeting compounds identified stearoyl-coenzyme A desaturase (SCD1) as a promising target for advanced PDAC. These results underscore the pivotal role of CTC-derived models in uncovering therapeutic avenues and ultimately advancing personalized care in PDAC.
The invention discloses a Chinese medicinal extract for treating diabetic peripheral neuropathy and a preparation method thereof. The Chinese medicinal extract is extracted from the following seven traditional Chinese medicines serving as raw materials in parts by mass: 600-1,200 parts of astragalus root, 600-1,200 parts of salvia miltiorrhizae, 400-600 parts of rhizoma cibotii, 400-600 parts of root of bidentate achyranthes, 400-600 parts of pawpaw, 400-600 parts of corydalis tuber and 400-600 parts of red paeony root. Clinical test results show that clinical symptoms of a patient of diabetic peripheral neuropathy can be obviously improved and nerve conduction velocity of the DPN patient can be effectively increased by the Chinese medicinal extract, and the overall effectiveness ratio reaches 90.3 percent; meanwhile, the improvement in the aspects of numbness, seismesthesia, spasm, touch sensation, pain, pinprick sensation and ankle reflection is also superior to that of a control group. The overall curative effect evaluation is obviously superior to that of a vitamin preparation, namely methycobal (P is less than 0.05), which is generally used in clinical practice at present. Blood routine and liver and kidney functions before and after treatment do not obviously differ; and during treatment, two groups of patients have no adverse effect. The compound granules are shown to be safe and effective for treating the diabetic peripheral neuropathy.
<P>PROBLEM TO BE SOLVED: To provide a nose protector, inserted in the nasal cavity to adsorb snivel.  <P>SOLUTION: This nose protector is characterized in that the nasal cavity is blocked up with a cylindrical or columnar absorbing material sucking up snivel. Preferably the absorbing material has permeability. Preferably the absorbing material has warmth keeping or moisture keeping property. Preferably a medicine is applied to or adsorbed to the absorbing material. Preferably the material quality of the absorbing material is the material used in paper diaper such as a tissue, absorbent paper, cohesion paper, high absorptive polymer sheet, absorbing sheet, cotton-like pulp, and polymer water absorbing material, or the material formed of water absorptive sponge or filter system of a cigarette or a compound thereof. Preferably the absorbing material is a material which may be burnt up after use.  <P>COPYRIGHT: (C)2007,JPO&INPIT