anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This protocol defines a prospective, open-label, multi-institutional, non-interventional study for the purpose of examining the Assay's clinical use and potential to impact patient outcomes. This Study will establish a registry of clinical parameters, including clinical response, clinical outcomes, Assay performance and potential utilization across multiple types of advanced cancers in consenting patients who have their tumor tissue tested by the Assay. Physicians may have access to Assay results which which predict therapeutic response to cancer drugs most often prescribed to treat the specified indications. For cancers with standard of care (SOC) cancer drug treatments, the Assay panel tests SOC systemic agents per NCCN guidelines, some of which may include both FDA approved and off-label FDA approved therapies. The Assay currently assesses the most common cancer drugs across multiple tumor types. It requires freshly obtained tumor specimen that has not been previously preserved for traditional histologic analysis. The Registry will focus initially on tumor types and agents which have been analytically validated with the Assay and determined to meet strict laboratory qualifications and standards. The Registry will collect data on a limited number of cancer types to include epithelial ovarian cancer (EOC), high-grade gliomas (HGG) limited to anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM), and high-grade rare tumors (RT).
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common severe dose-limiting side effects that accompany treatment with different chemotherapeutic agents. Patients with CIPN often experience a reduction in quality of life and an increase in fall risk due to symptoms such as pain, sensory loss, paresthesia (tingling, numbness), and gait disturbances. Treatment of CIPN is based on pharmacotherapy, which may in turn cause side effects such as nausea, dizziness, fatigue and others. In addition, various approaches from integrative medicine are used, e.g. acupuncture, touch therapies, mind-body medicine, dietary supplements, and aromatherapy. Little is known about the effect of rosemary oil, applied to hands and feet, on CIPN. The present study is a feasibility study to determine the feasibility of a future clinical trial to investigate the efficacy of topical application of rosemary oil in cancer patients undergoing chemotherapy who develop CIPN.
Individual researchers and consortia have been studying rare diseases for several decades. However, the rare disease community can be very fragmented mainly due to the large heterogeneity of rare diseases. Indeed, for many diseases, there is a very limited amount of researchers and resources available. Concerted efforts to organize the rare disease community and funding were emerging in several countries but so far, international coordination was rather limited. The International Rare Diseases Research Consortium (IRDiRC) aims to correct this. A part of this requires bringing rare disease researchers together for an international conference.
Chronic hepatitis B virus (HBV) infection can lead to advanced liver pathology. Here, we establish a transgenic murine model expressing a basic core promoter (BCP)-mutated HBV genome. Unlike previous studies on the wild-type virus, the BCP-mutated HBV transgenic mice manifest chronic liver injury that culminates in cirrhosis and tumor development with age. Notably, agonistic anti-Fas treatment induces fulminant hepatitis in these mice even at a negligible dose. As the BCP mutant exhibits a striking increase in HBV core protein (HBc) expression, we posit that HBc is actively involved in hepatocellular injury. Accordingly, HBc interferes with Fis1-stimulated mitochondrial recruitment of Tre-2/Bub2/Cdc16 domain family member 15 (TBC1D15). HBc may also inhibit multiple Rab GTPase-activating proteins, including Rab7-specific TBC1D15 and TBC1D5, by binding to their conserved catalytic domain. In cells under mitochondrial stress, HBc thus perturbs mitochondrial dynamics and prevents the recycling of damaged mitochondria. Moreover, sustained HBc expression causes lysosomal consumption via Rab7 hyperactivation, which further hampers late-stage autophagy and substantially increases apoptotic cell death. Finally, we show that adenovirally expressed HBc in a mouse model is directly cytopathic and causes profound liver injury, independent of antigen-specific immune clearance. These findings reveal an unexpected cytopathic role of HBc, making it a pivotal target for HBV-associated liver disease treatment. The BCP-mutated HBV transgenic mice also provide a valuable model for understanding chronic hepatitis B progression and for the assessment of therapeutic strategies.
For application of the Dry Needling the individual should be in the supine position. To facilitate the approach and adhesion of the Sternocleidomastoid Muscle, the person's neck is placed ipsilaterally in the slightly lateral flexed position. Consequently, the therapist identified the active Trigger Points in the Sternocleidomastoid Muscle and cleansed the surface using an antiseptic solution. Using the insertion pipe, the dry needle inserted into the muscle. For the separation of neurovascular structure from muscle belly the needle is carried out in an anterior-posterior direction. A compression of 90 secs with a cotton swab will be applied at the needling site immediately after removing the needle to reduce the intensity and duration of pain. The variables will then be measured immediately following the processing session. Six sessions of Dry Needling will be applied to each patient and there will be a gap of at least 48 hours between each session.
It is well known regular exercise produces both physical and cognitive benefits. Emerging evidence suggests that physical movements or exercise that have concurrent cognitive demands may have more profound effects on cognitive and brain health outcomes. One training program that incorporates these components is the square stepping exercise (SSE). First demonstrated in Japan, this community-based paradigm has already shown to reduce falls risk and presents as a convenient exercise modality for older adults, that can be conducted in a group setting or even the home. The current project aims to examine the efficacy of this SSE community programme in a Singapore context on cognitive and physical health in older adults. This study also aims to quantify the neural correlates underpinning any observed improvements in cognitive and physical function. Specifically, this project will measure indices of neuroplasticity via structural and functional magnetic resonance imaging, transcranial magnetic stimulation, and electroencephalography.

Sample size estimation: n=80 for behavioural primary outcome measures and n=40 subset of larger sample for neuroimaging and neuroplasticity secondary outcome measures \[anticipated\].
Parkinson's Disease (PD) affects about 1 million individuals in the United States. In addition to the typical motor dysfunction, PD also affects cognition and vision, even in early stages of the disease, impairing instrumental activities of daily living such as driving. Reduced cognitive speed of processing, or bradyphrenia, strongly contributes to cognitive decline in PD. Recent research has demonstrated that interventions can enhance cognitive speed of processing, protect against further cognitive decline, and improve the everyday functioning of relatively healthy, older adults. However, the potential of such training techniques to enhance cognitive functions among subpopulations with different disease states, such as PD, has not been thoroughly investigated. The proposed study will further examine the feasibility and test the efficacy of a well-established cognitive training tool among individuals in the early stages of PD who have not been diagnosed with dementia. A variety of factors have been found to influence cognitive performance among persons with PD and may moderate their ability to benefit from cognitive training such as age at disease onset, disease duration, manifestation, severity, and medication use as well as concomitant depression. These factors along with demographic variables will be evaluated as moderators of training benefit. Baseline cognitive assessments will be completed among seventy-five individuals with PD who will be randomized to cognitive training or a treatment-delayed control condition. The efficacy of training to immediately enhance cognitive functioning will be evaluated through a post-training (or equivalent delay) assessment. Disease and demographic factors that may impact the efficacy of cognitive training for persons with PD will be examined in relation to training gains. Considering that cognitive function among individuals with PD is a strong predictor of everyday functioning and subsequent need for long term care, enhancing cognitive function of individuals with PD through training has great potential to prolong such persons' productivity, independence, and quality of life. The information gained from this study will be useful for identifying individuals with PD who are most likely to benefit from cognitive training as well as the development, refinement, and implementation of appropriate cognitive interventions for this population.
A germicidal composition for the care of the oral cavity comprises particles of water insoluble plastics material with a size of less than 50 microns, which contain absorbed germicide. Suitable plastics materials are thermoplastic resins, e.g. polyvinyl chloride, polyethylene, polypropylene, polymethyl methacrylate and copolymers of polyvinylchloride and polyvinyl alcohol. Germicides may be hexachlorophene, chlorhexidene, tyrothricin, or quaternary ammonium compounds. The composition may be a dentifrice in the form of a liquid, paste, powder, tablets or a solid block, or may consist of a mouthwash conventional other ingredients for such forms are preferably present. The compositions are prepared by contacting particles of plastics material with a solution of the germicide in a solvent capable of being absorbed by the plastics material, (e.g. propylene glycol, glycerine, cineole, or mixtures thereof), separating the particles from excess solution and, if required, washing with the solvent. 'The absorption is preferably performed at an elevated temperature.
This invention relates to 10-hydroxycamptothecin arginine salt like the structure of formula (I). The preparation of this compound is in anhydrous solvent. 10-hydroxycamptothecin arginine reacts with arginine, obtaining related arginine salt and its compound. The quantity of adding arginine can be from 1 to 10 times of molar ratio. The water solubility of 10-hydroxycamptothecin arginine salt and its association object is obviously better than 10-hydroxycamptothecin, and possessing conspicuous liver target. It overcomes flaws such as noxious property of camptothecin sodium is high, stability is bad. It provides a medicine of which curative effect is reliable, medication is safe and cost is low for tumor patient.
No intervention will be made to the patients in the control group (n = 30). Patients in the control group will receive standard care and discharge education provided by the hospital. Discharge training consists of verbal information about the postoperative period. The "MMD Scale" will be applied to patients who meet the criteria 1 day before the surgery. Patients with a "BCS Scale" ≥ 89 will be included in the study. Patients will be interviewed face to face and written consent will be obtained. Sociodemographic and descriptive data will be obtained with the "Descriptive Patient Form". Discharge day after surgery (3rd day); Functional status level will be measured with KOOS. 3rd and 6th weeks after surgery; Functional status and self-care ability levels will be measured using the KOOS and Self-Care Power Scale, respectively.
The study will be performed in the Cardiac Rehabilitation Center at Assaf Harofeh Medical Center. Patients with coronary artery disease will be eligible to enroll.

Patient will undergo an exercise test on a stationary bicycle. TWA will be measured at heart rate of 105 and 115 BPM. The test will be repeated one week later in the same fashion. The patient will continue follow-up in the rehabilitation center as dictated by the rehabilitation program. Patients will be kept on their regular medications and there will be no change of the medications from the first TWA measurement to the second.
South Africa has one of the worst and fastest growing HIV epidemics in the world. Highly active antiretroviral therapy (HAART) has been shown both at the individual and public health levels to reduce morbidity, mortality, and vertical and possibly horizontal HIV transmission. However, expenses, feasibility, long-term adherence, and effective delivery of HAART remain formidable barriers, particularly in developing nations. Recently, international initiatives have provided hope for widespread use of HAART at affordable cost in sub-Saharan Africa. Simplified, once-daily HAART regimens with directly observed therapy (DOT) may help to achieve high levels of treatment adherence, a key component for long-term viral suppression and treatment success. Peer advocates have been used to improve adherence with medical therapies in a variety of settings. This study will evaluate the effectiveness and feasibility of DOT using patient-nominated peer supervisors to improve adherence to HAART in HIV infected adults in South Africa.

Participants will be randomly assigned to either Peer-DOT-HAART or self-administration of a once-daily combination of the Western Cape Province ART program medications for 24 months. Study measures will include CD4 cell count and HIV viral load, adherence questionnaires, genotypic HAART resistance testing, and incidence of new or recurrent opportunistic infections.
The invention discloses an oral traditional Chinese medicine preparation for treating dysmenorrhea. The preparation is prepared from the following active pharmaceutical ingredients in parts by weight: 8-10 parts of radix astragali, 15-20 parts of motherwort herb, 5-8 parts of fennel, 8-10 parts of largehead atractylodes rhizome, 8-12 parts of inner membrane of chicken gizzard, 15-20 parts of dried ginger, 10-15 parts of hawthorn, 10-15 parts of peach kernels, 15-20 parts of Chinese yam and 10-15 parts of dangshen. A preparation method comprises the steps of taking the active pharmaceutical ingredients, adding water to immerse the active pharmaceutical ingredients, decocting the active pharmaceutical ingredients for 1-2 hours, filtering the decoction, then adding water to the dregs to immerse the dregs, decocting the dregs for 0.5-1.5 hours, filtering the decoction and merging the two filtrates, thus obtaining the oral preparation. When used for treating dysmenorrhea, the preparation is taken orally once a day, a dose once for seven days. One course of treatment lasts seven days. Generally, the preparation takes an effect after being taken for two-three courses of treatment and cures dysmenorrhea after being taken for three-four courses of treatment. Through many years of clinical verifications, the preparation for treating dysmenorrhea has good curative effects, takes an effect quickly, does not have toxic or side effects, is simple to prepare and convenient to take, is low in price and is mainly used for treating primary dysmenorrhea.
PURPOSE:To decide in a short time on an oral material for medical treatment in a deciding device for the oral material for medical treatment by providing an input device which inputs data on the illness of a person to be treated medically and a deciding means which decides on the oral material for medical treatment from constitution and illness. CONSTITUTION:A CPU1 after initialization displays processing contents about six items on a display device 13 and indicates the numbers of the processing items. When No.1 is inputted on a keyboard 14, the code, examination date, age, and sex of an examinee by consultation are inputted to decide on the constitution of the examinee, thereby deciding on the prescription, therapeutic prescription, and prescription number of oral material for medical treatment which is effective to the examinee. When No.2 is inputted, answers and processes of consultation are displayed in a consultation list on the display device 13, and when No.3 is inputted, they are printed out on a printer 15. When No.4 is inputted, the prescription, therapeutic prescription, and prescription number of the oral material are displayed in a decision list, and when No.5 is inputted, they are printed out. When No.6 is inputted, whether display data are correct or not is confirmed and the operation is completed.
Subject that meet inclusion and exclusion criteria will be consented and enrolled in this study. Initial screening includes blood and urine testing, questionnaires, physical examination, specialized bladder function testing and review of medical history. At the next visit a small sample of each subject's own thigh muscle is obtained by needle biopsy. This cell biopsy is sent to a specialized lab for growth and processing. Approximately ten weeks later the frozen cells will be sent back to the treatment site for thawing, diluting and injection under lighted instrumentation into the subject's bladder wall. The subject will be followed for 6 months and at that time may be eligible for a second injection of cells. The study doctor will determine if the second injection may be beneficial to the subject. All subjects will be followed for up to 12 months. The follow-up assessments at 12 months will include questionnaires, urine and blood testing, specialized bladder function testing and visualizing the inside of the bladder with a lighted instrument.
Biocompatible polyhydroxyalkanoate compositions with controlled degradation rates have been developed. In one embodiment, the polyhydroxyalkanoates contain additives to alter the degradation rates. In another embodiment, the polyhydroxyalkanoates are formed of mixtures of monomers or include pendant groups or modifications in their backbones to alter their degradation rates. In still another embodiment, the polyhydroxyalkanoates are chemically modified. Methods for manufacturing the devices which increase porosity or exposed surface area can be used to alter degradability. For example, as demonstrated by the examples, porous polyhydroxyalkanoates can be made using methods that creates pores, voids, or interstitial spacing, such as an emulsion or spray drying technique, or which incorporate leachable or lyophilizable particles within the polymer. Examples describe poly(4HB) compositions including foams, coatings, meshes, and microparticles. As demonstrated by the examples, these polyhydroxyalkanoate compositions have extremely favorable mechanical properties, as well as are biocompatible and degrade within desirable time frames under physioogical conditions. These polyhydroxyalkanoate materials provide a wider range of polyhydroxyalkanoate degradation rates than are currently available. Methods for processing these materials, particularly for therapeutic, prophylactic or diagnostic applications, or into devices which can be implanted or injected, are also described.
The invention provides a method of extracting polysaccharide, volatile oil and lignans from Schisandra chinensis. The method comprises the steps of compound enzyme treatment, deionized water extraction, ethanol extraction, condensation, ethanol precipitation, separation, vacuum freeze drying and the like. According to the method, cellulase and pectase of a certain weight ratio are used for pretreatment of Schisandra chinensis, then a steam distillation method is utilized so as to extract volatile oil and polysaccharide, and ethanol extraction and separation are carried out so as to obtain an extract product containing lignans; the method enables three effective components to be obtained simultaneously. Since cell walls of Schisandra chinensis undergo enzymolysis because of enzyme treatment, yield of all the components is high, and the content of effective components in extract products is also high. Furthermore, integrated extraction of effective components in Chinese magnoliavine is favorable for promoting high valuation of the resource of Chinese herbal materials and benefits the cause of human health. The method provided in the invention has the advantage of a simple process.
LEAD consists of behavioral activation (BA) and motivational interviewing (MI), as well as discussions of masculinity and a family focus throughout to target father's depression symptoms and common comorbidities, like drinking. LEAD is guided by a manual (in Swahili and English). It includes five, 60-90-minute weekly sessions. LEAD was adapted for context based on formative work. Each session begins with MH assessment and review of activity completion and ends with homework to monitor activities. LEAD uses MI strategies to engage men in the treatment and increase commitment to addressing problems. MI strategies are then integrated throughout. (Session 1-5) to enhance father motivation to complete activities as well as to build self-efficacy (e.g., when reviewing homework, peer-father counselors reflect successes).
Over 450,000 women in the united states suffer from the medical disorder cystitis and several hundred in addition to this number, from urinary tract infections and premenstrual syndrome. Hundreds of clinical studies have shown the benefits of Kava Kava, Dandelion and L Arginine, each individually, as the relief for the many unpleasant symptoms that accompany cystitis, urinary tract infection and premenstrual syndrome. These beneficial results have been published in several prominent medical journals. Fem-Ease is a unique combination of all three ingredients together in one caplet. A light brown, cylinder shaped caplet with rounded corners, provides ease for the symptoms of cystitis, urinary tract infection and premenstrual syndrome. Two caplets in the morning and two caplets in the evening, provides a daily dose of 3000 mg of L Arginine, 790 mg of Kava Kava and 475 mg of Dandelion recommended to take at the first onset of symptoms.
Embodiments of the present application discloses a method and a related system for detecting medical conditions. In the method, a mobile computing device collects data (visual, sensor, etc.) from a user. A feature extraction circuit preprocesses the collected data to extract a feature. Based on the extracted feature, a prediction circuit determines a probability of the presence of a medical condition in the user. The embodiments provide a cost-effective and convenient approach to diagnosing certain health conditions that are visibly identifiable.
Radiotherapy with 2 Gy per fraction 5 or 6 times a week to 68-84 Gy to the planning target volume due to normal tissue tolerance constraints. Dose to lung tissue, esophagus and spinal cord will be considered. Three courses of cisplatin 75 mg/m2 day 1 and vinorelbine 25 mg/m2 day 1+8 will be given, two courses concomitant with radiation.