anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
<P>PROBLEM TO BE SOLVED: To provide a lipase activity promoter, a melanin formation inhibitor, an antiallergic agent or a histamine liberation inhibitor, a cosmetic composition or a food and drink which is each new and safe.  <P>SOLUTION: The lipase activity promoter, melanin formation inhibitor, antiallergic agent or histamine liberation inhibitor, cosmetic composition or food and drink comprises an extract from Thamnolia vermicularis, promotes the lipase activity, significantly inhibits even the formation of melanin, has bleaching effects and significantly inhibits the liberation of the histamine. Furthermore, the lipase activity promoter, melanin formation inhibitor, antiallergic agent or histamine liberation inhibitor, cosmetic composition or food and drink ameliorates oily skin/acne vulgaris/eczema/skin inflammatory disease (e.g. flare or edema) and skin roughening, further ameliorates stains/ephelides of skin, imparts tenseness/luster to the skin and is effective for aging prevention of the skin or scalp and aging prevention for diseases such as life style related diseases. The lipase activity promoter, melanin formation inhibitor, antiallergic agent or histamine liberation inhibitor, cosmetic composition or food and drink is safe even for internal use or external use in humans or animals and can be applied to pharmaceutical preparations in all forms (medicines, quasi-drugs, cosmetics or foods).  <P>COPYRIGHT: (C)2006,JPO&NCIPI
The present disclosure describes functional oligomers or functional polymers. The functional oligomers or functional polymers may contain functional groups,  e.g. , -OH and/or -CHO. The functional oligomers or functional polymers may be obtained from hydrolyzing certain copolymers and may be soluble in commercially available solvents. The copolymers may be thermosetting polymers. The functional oligomers and functional polymers may be useful for recycling thermosetting polymers and may be useful as starting materials for preparing additional oligomers or polymers.
PURPOSE: Data on the effects of obesity on drug exposure of oral targeted oncolytics is scarce. Therefore, the aim of this study was to investigate the influence of body weight and body mass index (BMI) on trough levels of oral oncolytics with an exposure-response relationship. The oral oncolytics of interest were abiraterone, alectinib, cabozantinib, crizotinib, imatinib, pazopanib, sunitinib and trametinib.
METHODS: This retrospective cohort study included patients treated with the selected oral oncolytics at the standard dose, with a measured trough level at steady state and with available body weight. The Spearman's correlation test was used to determine the correlation between body weight and trough levels. The Fisher's exact text was used to compare the frequency of inadequate trough levels between BMI categories.
RESULTS: 1265 patients were included across the different oral oncolytics. A negative correlation coefficient was observed between weight and trough levels for crizotinib (n = 75), imatinib (n = 201) and trametinib (n = 310), respectively, ρ = - 0.41, ρ = - 0.24 and ρ = - 0.23, all with a p-value < 0.001. For crizotinib, a higher percentage of patients with a body weight > 100 kg had inadequate trough levels. No statistically significant differences were observed in the frequency of inadequate trough levels between BMI categories.
CONCLUSION: Higher body weight was only correlated with lower plasma trough levels for crizotinib, imatinib, and trametinib. Therefore, patients with a high body weight may require dose escalation to obtain adequate target levels when treated with these oral oncolytics.
PROBLEM TO BE SOLVED: To obtain an aqueous nail enamel excellent in adhesivenless in long- term water-immersion, resistance to whitening due to water and lasting of makeup. SOLUTION: This aqueous nail enamel is obtained by using emulsion consisting mainly of an acrylic resin obtained by emulsion polymerization using a phosphate-based emulsifier. The phosphate-based emulsifier is used in a range of >=0.5 pt.wt. to <=10 pts.wt. based on 100 pts.wt. total resin component. The acrylic resin is obtained by copolymerizing a hydrophilic monomer with a hydrophilic monomer. The average particle diameter of dispersoid of the emulsion is >=30 nanometer and <=200 nanometer. A film-forming auxiliary in an amount of >=0.5 pt.wt. and <=50 pts.wt. based on 100 pts.wt. total resin component is added to the aqueous nail enamel.
PURPOSE:To obtain the subject highly safe inhibitor having activity to improve blood lipid level balance, thus excellent in effect of inhibiting arteriosclerosis. CONSTITUTION:This arteriosclerosis inhibitor consisting of an extract from root of Astragalus huantchy. The extract can be obtained by the following processes: root of Astragalus huantchy, pref. its root rich in medicinal ingredient(s) is dried and cut into fine pieces, and then immersed in water and/or a polar organic solvent at room temperature for 1-3 days, or at the boiling point of the extraction solvent for 1-5hr, followed by, if needed, removing insolubles through filtration, or concentration under reduced pressures or by ultrafiltration and then evaporating the solvent to dryness. The extract can be pref. obtained by warm water extraction, filtration and then lyophilization. This inhibitor is used as a medicinal composition for treating circulatory diseases, or as a health food or functional food.
The preferable method of use is to apply Salycim™ Cream thoroughly to the affected area and to cover the treated area at night after washing and before retiring. Preferably, the skin should be hydrated for a least five minutes prior to application. The medication is washed off in the morning and if excessive drying and/or irritation is observed, a bland cream or lotion may be applied. Once clearing is apparent, the occasional use of Salycim™ Cream will usually maintain the remission. In those areas where occlusion is difficult or impossible, application may be made more frequently; hydration by wet packs or baths prior to application apparently enhances the effect. (See WARNINGS.) Unless hands are being treated, hands should be rinsed thoroughly after application. Excessive repeated application of Salycim™ Cream will not necessarily increase its therapeutic benefit, but could result in increased local intolerance and systemic adverse effects such as salicylism.
The invention relates to skin oils containing fat, containing one or more oil soluble components, one more W/O emulsifiers with a hydrophilic-lipophilic balance of 2-6, preferably 5.9, one of more vesicle forming lipids and , optionally, one or more additive selected from etherical oils, antioxidants, perfumed materials, preservatives, active ingredients, UV filters, vitamins, consistency modulators and solubilizers. The invention also relates to the production and the use of the said skin oil, particularly as a skin care oil, sport oil, massage oil or sun protection oil. Said skin oils can be applied on dry skin and particularly on wet skin. Said oil is self-emulsifying and spontaneously forms liposomes. Said oil also has the advantage as it can easily penetrate the skin without leaving a disturbing layer of fat thereon. 17 claims, 3 figures
Ergothioneine (EGT) is a sulfur-containing amino acid with strong antioxidant activity. In this study, a D-galactose induced mouse aging model was used to investigate the anti-aging effects of EGT. EGT intervention could significantly improve the recognition memory of aging mice. Additionally, it improved the D-galactose induced decrease in the number of neurones, enhanced the levels of cAMP and BDNF in the brain, and increased the density and expression of PSD95 in aging mice. Meanwhile, EGT could attenuate oxidative stress by reducing the content of MDA and enhancing T-SOD activity via the Nrf2/HO-1 pathway. In addition, EGT could alleviate mitochondrial function by regulating the AMPK/SIRT1/PGC-1α pathway, which in turn attenuated D-galactose induced hippocampal neuronal injury and improved the learning and memory abilities in mice. This study provides a potential dietary strategy to improve age-induced memory impairment.
This arm involves the wear of a daily disposable soft contact lens (nesofilcon A) designed as a regular optical device to compensate for refractive error. In the case of this study, this lens will be made available from -1.00D to -4.00D. This lens is already in regular use in the US (K113703) and Canadian markets. Its design includes a central optical zone of 8mm that is powered to correct distance vision. The rest of the lens is supported on the ocular surface and has no power.
Hydroxyurea is used alone or in conjunction with other antitumor agents or radiation therapy to treat neoplastic diseases. Individualize treatment based on tumor type, disease state, response to treatment, patient risk factors, and current clinical practice standards.

Base all dosage on the patient’s actual or ideal weight, whichever is less.

Hydroxyurea is a cytotoxic drug. Follow applicable special handling and disposal procedures [see References (15)]. 

Swallow hydroxyurea capsules whole. Do NOT open, break, or chew capsules because hydroxyurea is a cytotoxic drug.

Prophylactic administration of folic acid is recommended [ see Warnings and Precautions (5.7)]. 

Monitor blood counts at least once a week during Hydroxyurea capsules therapy. Severe anemia must be corrected before initiating therapy with Hydroxyurea capsules.
During the procedure, the distal part of the stomach is resected, but a pyloric cuff 2-3 cm wide is preserved. The right gastric artery and the infrapyloric artery are preserved to maintain the blood supply to the pyloric cuff. In addition, the hepatic and pyloric branches of the vagal nerves are preserved to maintain pyloric function. The celiac branch of the posterior vagal trunk is sometimes preserved. All regional nodes except the suprapyloric nodes (No. 5) should be dissected as in the standard D2 procedure. However, there are technical challenges associated with completing all of these procedures.The five-year survival rate after PPG with modified D2 lymph node dissection ranges from 95% to 98%. This rate is comparable to the five-year survival rate after gastric resection for EGC, which ranges from 90% to 98%. In terms of oncologic safety, PPG seems reasonably safe for EGC when the accuracy of preoperative diagnosis can be assured
The invention discloses an andrographolide sulfonate and a preparation method and application thereof, and relates to the technical field of pharmacy. The method comprises dissolving andrographolide in a first solvent; dissolving sulfur trioxide in a second solvent, wherein the second solvent is a nonaqueous aprotic solvent; adding sulfur trioxide into andrographolide for reaction to obtain a reaction solution, regulating the pH value of the reaction solution to be neutral, and removing a solvent to obtain a crude product; dissolving the crude product with distilled water, filtering to obtain filtrate, removing solvent to obtain solid, and drying. The method uses sulfur trioxide as sulfonating agent of andrographolide, and has the characteristics of high reaction activity and mild condition. The reaction system is a non-aqueous system, and can effectively avoid the generation of concentrated sulfuric acid by sulfur trioxide and water, so that the hydrolysis damage and dehydration carbonization of the product are avoided, and the yield and quality of the product are ensured. The method has simple process and convenient operation, and is suitable for industrial production. The andrographolide sulfonate prepared by the method has the effects of prolonging the antibody protection period, increasing the weight and resisting tumors.
Linkages between alcohol use and HIV/sexual risk behaviors have been observed in multiple groups and each behavior has been successfully treated individually. Indeed, some studies suggest these behaviors can be successfully treated together. The Emergency Department (ED) provides a venue through which many patients with multiple risks are treated. Yet, to date no study has addressed these behaviors together in an ED, where admission may represent an opportunistic moment when patients are particularly willing to discuss these risky behaviors. Motivational Interviewing (MI) has demonstrated promise with alcohol risk in the ED in several of our previous studies, and has shown promise with sexual risk populations as well. Accordingly, this study (N=302) will address whether a one session multiple risk MI can more effectively decrease and maintain reduction in alcohol use, alcohol related problems, and sexual risk taking following discharge from the ED than Brief Advice (BA). Baseline, MI Session 1 and BA will be administered in the ED. Follow-ups will be conducted at 3, 6 and 9 months. This project will allow us to address the next phase of our program of research that has been designed to develop easily disseminable treatments for high-risk populations in medical settings. This study will also address potential mediators (motivation to change risk taking, self-efficacy) of MI effects. We will also examine whether reductions in sexual risk associated with MI compared to BA are accounted for by reduced drinking. A tertiary aim will examine the moderating effect of co-occurring substance use on outcomes. The cost-effectiveness of the interventions will also be addressed. Thus, this study will address two significant Public Health problems and provide significant information about MI mechanisms that may be relevant to the treatment community.
Aster proteins mediate the nonvesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER). However, the importance of nonvesicular sterol movement for physiology and pathophysiology in various tissues is incompletely understood. Here we show that loss of Aster-B leads to diet-induced obesity in female but not in male mice, and that this sex difference is abolished by ovariectomy. We further demonstrate that Aster-B deficiency impairs nonvesicular cholesterol transport from the PM to the ER in ovaries in vivo, leading to hypogonadism and reduced estradiol synthesis. Female Aster-B-deficient mice exhibit reduced locomotor activity and energy expenditure, consistent with established effects of estrogens on systemic metabolism. Administration of exogenous estradiol ameliorates the diet-induced obesity phenotype of Aster-B-deficient female mice. These findings highlight the key role of Aster-B-dependent nonvesicular cholesterol transport in regulating estradiol production and protecting females from obesity.
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     Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum required. Follow patients for signs and symptoms of respiratory depression and sedation (see WARNINGS and PRECAUTIONS and PRECAUTIONS, Drug Interactions).
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     The use of benzodiazepines, including chlordiazepoxide hydrochloride, a component of Librax, exposes users to risks of abuse, misuse, and addiction, which can lead to overdose or death. Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes. Before prescribing Librax and throughout treatment, assess each patient’s risk for abuse, misuse, and addiction (see WARNINGS).
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     The continued use of benzodiazepines, including Librax, may lead to clinically significant physical dependence. The risks of dependence and withdrawal increase with longer treatment duration and higher daily dose. Abrupt discontinuation or rapid dosage reduction of Librax after continued use may precipitate acute withdrawal reactions, which can be life-threatening. To reduce the risk of withdrawal reactions, use a gradual taper to discontinue Librax or reduce the dosage (see WARNINGS and DOSAGE AND ADMINISTRATION).
Duplication of all genes associated with X-linked intellectual disability (XLID) have been reported but the majority of the duplications include more than one XLID gene. It is exceptional for whole XLID gene duplications to cause the same phenotype as sequence variants or deletions of the same gene. Duplication of PLP1, the gene associated with Pelizaeus-Merzbacher syndrome, is the most notable duplication of this type. More commonly, duplication of XLID genes results in very different phenotypes than sequence alterations or deletions. Duplication of MECP2 is widely recognized as a duplication of this type, but a number of others exist. The phenotypes associated with gene duplications are often milder than those caused by deletions and sequence variants. Among some duplications that are clinically significant, marked skewing of X-inactivation in female carriers has been observed. This report describes the phenotypic consequences of duplication of 22 individual XLID genes, of which 10 are described for the first time.
CC-type chemokines belong to a family of polypeptides which have been shown to mediate immune reactions and have recently attracted attention because of their antiviral activity against HIV. The invention relates to the cloning and molecular characterisation of a human tandem gene which contains closely linked coding sites for two new CC-type chemokines whose sequences are similar to a high degree to those of MIP-1 alpha . The transcription of the tandem gene leads to a bicistronic mature transcript which contains the non-overlapping open reading frames for the recently described HCC-1 factor and for a hitherto unknown CC-type chemokine, named CC-2. Moreover, by alternatively splicing the primary transcript, at least one other CC-type chemokine, the CC-3 cytokine, is obtained. Within the tandem gene two functional promoter sites could be identified. The disclosed data give fundamental information about the structure and expression of the new human CC-2/HCC-1 tandem gene and describe a mechanism which could be used to regulate the co-expression of closely linked genes in higher eukaryotes.
Patients in Group PCS (patient-controlled sedation) received intravenous (IV) propofol via a patient controlled analgesia (PCA) infusion pump. The machine was set to deliver a demand bolus dose of 0.25 mg/kg with 1-minute lockout interval, without basal infusion.The patient was instructed to press on a hand-held device as often as required, to achieve their desired level of comfort or sedation.
Eight sessions of education with content designed to mirror the information covered in the intervention condition. The content will be as follows: 3 sessions focusing on medication adherence; 3 sessions focusing on the dangers of methamphetamine use; 1 session addressing sexual risk; and 1 session addressing poly-substance use.
Qingwanzi Pills (QP) were first mentioned in the "Puji Fang" of the Ming Dynasty, with a history of approximately 600 years. The formula consisted of Gypsum Fibrosum and Indigo Naturalis. It is a famous classical formula with antipyretic effects frequently utilized in ancient China, although our knowledge about the overall antipyretic mechanism of QP remains limited. Therefore, we replicated the fever model in New Zealand rabbits induced by lipopolysaccharide, performed the pharmacodynamic evaluation of QP, identified the differential metabolites among QP groups, and performed pathway enrichment analysis to comparatively analyze the effects of QP on fever-related metabolic pathways by ultra-performance liquid chromatography-mass spectrometry. The results showed that the antipyretic effect of QP was superior to that of each disassembled prescription, with Gypsum Fibrosum primarily contributing to the efficacy, followed by Indigo Naturalis and Junci Medulla. QP had an effective antipyretic effect, which was related to lowering the levels of TNF-α, IL-6, IL-1β, and calcium in rabbit serum, lowering the levels of PGE2 and cAMP in rabbit cerebrospinal fluid, and increasing the level of calcium in rabbit cerebrospinal fluid. A total of 27 endogenous biomarkers were screened by serum metabolomics for the treatment of fever with QP. It is hypothesized that the antipyretic mechanism of QP may be related to regulating α-linolenic acid, sphingolipid, tryptophan, and bile acid metabolism. In summary, QP exhibited a significant antipyretic effect in rabbits with lipopolysaccharide-induced fever.
The intervention consists of a physical activity educational workshop and consultation. The child care health consultants (CCHCs) conduct the educational workshop for the child care center directors and providers on physical activities center policies and best practices over 7 months. The workshop includes a Physical Activity Toolkit and toolbox. The (CCHCs) meet with center directors to review the results of the Baseline observational Checklists and to identify center-specific intervention goals. The intervention also includes 7 monthly child care health consultation visits where the CCHC and director review the center's progress towards the intervention goals, discuss problems, and share resources.
An aqueous sucrose containing suspension for coating cores, e.g. chewing gum cores, to produce dragees, comprises 45 - 85% by weight sucrose, 5 - 20% by weight fillers, and 0.01 to 10% by weight fat or fatty oil and/or ester wax.  Substances which may be present in the composition include glucose, maltose, dextrines, starch, chalk, titanium dioxide, palmitin, cocoa-butter, butter, cream, beeswax, parting wax, olive oil, lecithin, sodium alginate, margarine, peppermint oil, comprisuate wax and milk powder.  The cores are placed in a dragee making kettle and periodically sprayed with the suspension, drying periods being provided between each spraying, and the various steps in the process being carried out automatically. Warm air is used in the drying steps.  The process may be carried out in the device described in Specification 968,442.ALSO:An aqueous sucrose containing suspension for coating cores, e.g. chewing gum cores, to produce dragees, comprises 45-85% by weight sucrose, 5-20% by weight fillers, and 0.01 to 10% by weight fat or fatty oil and/or ester wax.  Substances which may be present in the composition include glucose, maltose, dextrines, starch, chalk, titanium dioxide, palmitin, cocoa-butter, butter, cream, beeswax, parting wax, olive oil, lecithin, sodium alginate, margarine, peppermint oil, comprimate wax and milk powder.  The cores are placed in a dragee making kettle and periodically sprayed with the suspension, drying periods being provided between each spraying, and the various steps in the process being carried out automatically.  Warm air is used in the drying steps.  The process may be carried out in the device described in Specification 968,442.
Hyperuricaemia (HUA) is an abnormally high concentration of serum urate caused by either an excess of uric acid production or decreased excretion capacity in the body. Serum urate concentration forms sodium salts that deposit in the soft tissues of the joints, ultimately leading to gout. Additionally, HUA is strongly associated with several acute and chronic illnesses. In various clinical guidelines and practices, xanthine oxidase inhibitors, such as allopurinol and febuxostat, are commonly used as the initial medication for treating HUA. However, extended usage of urate-lowering drugs may have risks, including cardiovascular thrombotic events and hepatic impairment. Implementing a scientifically informed fitness diet in conjunction with appropriate exercise may decrease HUA. Unfortunately, there is currently a shortfall in exercise intervention trials for individuals suffering from HUA. Most of the previous evidence suggesting that exercise improves serum urate levels comes from intervention trials in other populations, and serum urate is only one of the outcomes observed. This opinion article analyses the causes of HUA, offers dietary and exercise guidance with the aim of furnishing a point of reference for individuals with HUA or fitness enthusiasts.