anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
In Hong Kong, 3.9% of adolescents were diagnosed as having Attention Deficit/Hyperactivity Disorder (ADHD). The primary symptoms of ADHD include inattention, hyperactivity, and impulsivity, which limit learning and socioemotional development. ADHD has been associated with poor family functioning, increased stress within the family, higher rates of parental psychopathology, and conflicted parent-child relationships. More than 70% of children with ADHD experience improvements after treatment with psychostimulant medication but some children demonstrate side effects. Behavioral interventions have been found to be effective in enhancing motivation and decreasing the disruptive behaviors of children with ADHD. However, some parents of children with ADHD experience high levels of stress, and the children's symptoms and reactions often complicate their application of the techniques taught in parent behavioral training programs. Moreover, while children benefit from behavioral training in short-term improvements, its long-term effects are uncertain, as children with ADHD cannot learn self-regulation without parental supervision. In recent reviews and randomized controlled trials, mindfulness-based intervention (MBI) has shown its benefits in improving ADHD symptoms and parent's mental health. Practitioners and researchers have collaborated to apply technology and convert face-to-face MBIs into online or app-based MBIs. Our research team modified the ordinary MBI program structure by integrating short daily online psychoeducation videos with audio mindfulness guidance. In view of the poor engagement and high dropout issues of many online programs, our program is strengthened by incorporating four weekly, real-time online meetings with instructors. The content of MBI includes mindfulness and attention, mindfulness and physical sensation, mindfulness and parental stress, and mindfulness and self-care. The majority of the exercises are for parents, but additional guidance for child-parent mindfulness exercises is included. One module will target children with ADHD and the length of video and audio of mindfulness exercises for children. This study will investigate the effects of an online MBI, with a randomized controlled trial. A total of 208 parents will be recruited, and randomly assigned to online MBI and psychoeducation. The effects of the MBI will be investigated in comparison with the effects of psychoeducation and outcomes on child ADHD symptoms, parent mental health, and family expressed emotions will be measured. Immediate effect at post-intervention, and 6-month follow-up maintenance effect will be investigated.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent condition with a broad spectrum defined by liver biopsy. This gold standard method evaluates three features: steatosis, activity (ballooning and lobular inflammation), and fibrosis, attributing them to certain grades or stages using a semiquantitative scoring system. However, liver biopsy is subject to numerous restrictions, creating an unmet need for a reliable and reproducible method for MASLD assessment, grading, and staging. Noninvasive imaging modalities, such as magnetic resonance imaging (MRI), offer the potential to assess quantitative liver parameters. This review aims to provide an overview of the available MRI techniques for the three criteria evaluated individually by liver histology. Here, we discuss the possibility of combining multiple MRI parameters to replace liver biopsy with a holistic, multiparametric MRI protocol. In conclusion, the development and implementation of such an approach could significantly improve the diagnosis and management of MASLD, reducing the need for invasive procedures and paving the way for more personalized treatment strategies.
A computing system for generating a delayed electronic prescription for a controlled substance is disclosed herein. A server computer device receives precursor data for an electronic prescription for a controlled substance that is to be prescribed to a patient from a client computing device operated by a healthcare worker. The server computing device transmits the precursor data to a second server computing device. The second server computing device then transmits a request for an identity of a pharmacy that is to provide the controlled substance to a patient computing device operated by the patient. The patient computing device receives input causing the identity for the pharmacy to be received by the server computing device. The server computing device constructs the electronic prescription using the precursor data and the identity of the pharmacy and signs the electronic prescription with an electronic signature for the healthcare worker.
NEW MATERIAL:A fluorine-containing phenone based compound expressed by formula I (R is lower alkyl). EXAMPLE:2-Chloro-4,5-difluoroacetophenone. USE:Useful as an intermediate for synthesizing benzoic acid and further as an intermediate capable of driving to a quinone carboxylic acid useful as synthetic antigerm gent synthesized by well-known reactions having several steps. PREPARATION:1-Chloro-3-difluorobenzene expressed by formula II is reacted with a carboxylic acid chloride such as acetyl chloride or a carboxylic anhydride such as acetic anhydride in the presence of an acylating catalyst at 0-200 deg.C, preferably 10-150 deg.C to provide the compound expressed by formula I. The acylated catalyst includes Bronsted acid such as AlCl3 or HPOF2 and used at an amount of 0.1-500mol.% based on the compound expressed by formula II. The reaction temperature is 0-200 deg.C, preferably 10-150 deg.C.
Participants in the physical activity program will participate in 12 weekly 1.5-hour sessions focused on increasing physical activity. The group sessions will include participating in physical activity as well as group discussions on the barriers and opportunities for increasing physical activity in their daily life. The 12-week program covers educational topics related to physical activity (e.g. overcoming barriers to activity, exercising safely, relapse prevention strategies) and the program gradually increases the amount of physical activity completed during the group sessions over the course of the 12 weeks. Over a 3-month wait period, individuals in the wait-list control group will be offered monthly sessions on health and wellness topics before being offered the physical activity program. Measurement visits will occur at baseline, at the end of the12-week program, and approximately 12-weeks after the end of the intervention. During the measurement sessions participants will complete assessments related to their physical activity and other health behaviors.
Insulin Lispro A 20 units (U) of strength 200 units per milliliter (U/mL) (U-200)administered subcutaneously (SC) once in two of four study periods.(Two doses of test \[T\]).
In clinical studies, diarrhea developed in 60 of 603 (10%) and 16 of 400 (4%) of patients treated with 200 mg Comtan and placebo, respectively. In patients treated with Comtan, diarrhea was generally mild to moderate in severity (8.6%) but was regarded as severe in 1.3%. Diarrhea resulted in withdrawal in 10 of 603 (1.7%) patients, 7 (1.2%) with mild and moderate diarrhea and 3 (0.5%) with severe diarrhea. Diarrhea generally resolved after discontinuation of Comtan. Two patients with diarrhea were hospitalized. Typically, diarrhea presents within 4 weeks to 12 weeks after entacapone is started, but it may appear as early as the first week and as late as many months after the initiation of treatment. Diarrhea may be associated with weight loss, dehydration, and hypokalemia.

Postmarketing experience has shown that diarrhea may be a sign of drug-induced microscopic colitis, primarily lymphocytic colitis. In these cases, diarrhea has usually been moderate to severe, watery, and non-bloody, at times associated with dehydration, abdominal pain, weight loss, and hypokalemia. In the majority of cases, diarrhea and other colitis-related symptoms resolved or significantly improved when Comtan treatment was stopped. In some patients with biopsy confirmed colitis, diarrhea had resolved or significantly improved after discontinuation of Comtan but recurred after retreatment with Comtan.

If prolonged diarrhea is suspected to be related to Comtan, the drug should be discontinued and appropriate medical therapy considered. If the cause of prolonged diarrhea remains unclear or continues after stopping entacapone, then further diagnostic investigations including colonoscopy and biopsies should be considered.
The recommended dose of ERLEADA is 240 mg administered orally once daily. This could be administered as one 240 mg tablet or four 60 mg tablets. Swallow the tablet(s) whole. Do not crush or split tablet(s). ERLEADA can be taken with or without food.

Patients should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had a bilateral orchiectomy.
Healthy children, 6-12 years old, will undergo screening for H. pylori infection by measuring anti-H. pylori and CagA IgG antibodies in the serum. The status of H. pylori infection will be confirmed using breath test (UBT). Children will be classified as i) H. pylori negative, if they test negative on UBT ii) H. pylori positive- CagA negative, if they test positive on UBT, but lack serum CagA IgG antibodies iii) H. pylori positive- CagA positive, if they are positive for H. pylori on UBT and CagA IgG antibodies.
The invention discloses a hospitalization ward data supervision and processing system, a use method and application thereof. The data supervision and processing system comprises at least one group of RFID tags, at least one group of radio frequency readers, an STM32 single chip microcomputer and an upper computer. The RFID tag is used for recording basic information of the inpatients and corresponds to the inpatients one to one. The radio frequency reader is used for reading and collecting the information of the RFID label. The STM32 singlechip is used for receiving and processing the information collected by the radio frequency reader. And the upper computer and the STM32 single chip microcomputer communicate with each other to transmit and gather data. The inpatient area data supervision and processing system has the advantages of networked management, high working efficiency in the aspects of inpatient area management, diagnosis and treatment nursing, logistics support, patient flow regulation, safety monitoring and the like, and the RFID tag is applied to the inpatient area based on the radio frequency identification technology, so that the patient data information is updated and displayed in real time, and the medical staff can provide real-time help and navigation prompt conveniently.
The invention relates to a water-soluble active extract derived from fruit peels, the preparation method and the application thereof. The fruit peel is treated by the steps of drying, pulverization, extraction, flocculation, separation and concentration, to prepare a water-soluble active extract. Then, the extract is added in cosmetic matrixes to allow a cosmetic to have skin-whitening and anti-skin ageing functions. The fruit peel extract is obtained after the screening of tyrosinase-inhibiting, antioxidant and free radical-scavenging activities in the water-soluble extracts of fruit peels such as Citrus peels, and has skin-whitening and anti-skin ageing effects. The water-soluble active extract has the advantages of easily-accessible raw materials, renewable resources and simple preparation method. The obtained extract has good stability and durable effect and serves as cosmetic additives in any stage of cosmetic production, without the risks of solvent residue and microbial contamination.
Disclosed is a composition for oral care which comprises the following natural substances: unrefined sodium chloride; Zanthoxylum schinifolium Sieb. et Zucc.; Saposhinkovia divaricata (Turcz) Shicschk; Angelica dahurica; and Asarum heterotropoide Fr. Schimidt var. mand shuricurn (Maxim.) Kitag. The compound natural substance is a prescription that has the effects of treating oral diseases, whitening, and removing tartar.
Temsirolimus injection is supplied as a kit consisting of the following: 

Temsirolimus injection (25 mg/mL). The Temsirolimus injection vial contains temsirolimus at a concentration of 25 mg/mL. The vial contains an overfill of 0.2 mL to ensure the ability to withdraw the recommended dose. 

DILUENT for Temsirolimus injection. The DILUENT vial includes a deliverable volume of 1.8 mL. This vial contains an overfill in order to ensure that the appropriate volume can be withdrawn.
The invention discloses an ointment for therapy of sores and ulcers on body surface and a preparation method thereof. The ointment comprises, by weight, 10-15 parts of centipedes, 10-15 parts of pangolins, 100-200 parts of sesame oil, 15-20 parts of sodium carboxymethylcellulose, 15-20 parts of gelatin and 15-20 parts of colloid. The invention solves the defects that conventional traditional Chinese medicine ointments cannot absorb wound exudation and has high side effect due to long-term application of antibiotics for therapy. The ointment has good anti-inflammatory and pain-relieving effects, can eliminate edema on wound surface, can absorb the wound exudation and has excellent breathability and comfort. The ointment has simple formula, scientific and reasonable ingredients, has unique production process, can treat both exterior and interior, is easy to apply, has no toxic and side effects, and has wide indications. With oil as a substrate, the ointment is gentle and can lubricate the wound surface, is free of discomfort feelings, such as caking, hardening and sticking and has no irritation; by means of the added auxiliary materials, the ointment can absorb 5-10 times of the wound exudation.
Healing caps will be placed until loading. The minimum waiting time is 4 weeks, but not before "try ins" to ensure a perfect fit. The implants must be restored (loaded) with a permanent screw retained fixed partial denture (FPD) within 42-56 days (6 to 8 weeks) of surgery.
<P>PROBLEM TO BE SOLVED: To provide a medical chart form No.1 issuance system for simultaneously issuing a chart form No.1 and a consultation card, wherein the issued consultation card displays information on other medical institutions.  <P>SOLUTION: A chart form No.1 issuance system 2 includes a data processor 4 for performing processing such as issuing the chart form No.1. The data processor 4 is connected to an input unit 6 for inputting patient information on a patient, insurance information on medical insurance of the patient, and information on other medical institutions presented by the patient; and to a data storage unit 8 for storing the insurance information and the other institution information so as to correspond with a patient identification code. The data processor 4 is further connected to a printer 10. The printer 10 prints, at a predetermined position on the consultation card integrated with the chart form No.1, a name or an institution code of a medical institution issuing the consultation card, the patient identification code, predetermined information selected from the patient information, and the other institution information. The printer 10 also prints, at a predetermined position on the chart form No.1, the patient information and the insurance information.  <P>COPYRIGHT: (C)2004,JPO
Placebo pill is made up of a certain amount of starch and glucose, and is shaped like GSATP according to the National Drug Standards of the State Food and Drug Administration of China. Placebo pill was required to be taken orally, 6g three times daily combined with vaginal progesterone (90 mg/day Crinone, Merck) from the day of embryo transfer until 10th gestational week.
The protocol for the deep breathing practice will be adapted from the procedure outlined in (Cheng et al., 2019). Participants randomized to the deep breathing group will undergo mindful deep breathing practice. Participants will be required to follow an instructional video and perform mindful deep breathing. The video guide will be sent to each participant in the deep breathing group, and they will be instructed to perform the exercise once a day at any time of their choice for the 14-day period.
BACKGROUND: Androgen deprivation therapy (ADT) is the mainstay treatment for advanced prostate cancer. But ADTs with orchiectomy and gonadotropin-releasing hormone (GnRH) agonist are associated with increased risk of cardiovascular diseases, which appears less significant with GnRH antagonist. The difference of follicle-stimulating hormone (FSH) in ADT modalities is hypothesized to be responsible for ADT-associated cardiovascular diseases.
METHODS: We administered orchiectomy, GnRH agonist, or GnRH antagonist in male ApoE-/- mice fed with Western diet and manipulated FSH levels by testosterone and FSH supplementation or FSH antibody to investigate the role of FSH elevation on atherosclerosis. By combining lipidomics, in vitro study, and intraluminal FSHR (FSH receptor) inhibition, we delineated the effects of FSH on endothelium and monocytes and the underlying mechanisms.
RESULTS: Orchiectomy and GnRH agonist, but not GnRH antagonist, induced long- or short-term FSH elevation and significantly accelerated atherogenesis. In orchiectomized and testosterone-supplemented mice, FSH exposure increased atherosclerosis. In GnRH agonist-treated mice, blocking of short FSH surge by anti-FSHβ antibody greatly alleviated endothelial inflammation and delayed atherogenesis. In GnRH antagonist-treated mice, FSH supplementation aggravated atherogenesis. Mechanistically, FSH, synergizing with TNF-α (tumor necrosis factor alpha), exacerbated endothelial inflammation by elevating VCAM-1 (vascular cell adhesion protein 1) expression through the cAMP/PKA (protein kinase A)/CREB (cAMP response element-binding protein)/c-Jun and PI3K (phosphatidylinositol 3 kinase)/AKT (protein kinase B)/GSK-3β (glycogen synthase kinase 3 beta)/GATA-6 (GATA-binding protein 6) pathways. In monocytes, FSH upregulated CD29 (cluster of differentiation 29) expression via the PI3K/AKT/GSK-3β/SP1 (specificity protein 1) pathway and promoted monocyte-endothelial adhesion both in vitro and in vivo. Importantly, FSHR knockdown by shRNA in endothelium of carotid arteries markedly reduced GnRH agonist-induced endothelial inflammation and atherosclerosis in mice.
CONCLUSIONS: FSH is responsible for ADT-associated atherosclerosis by exaggerating endothelial inflammation and promoting monocyte-endothelial adhesion.
Exercise may differently affect the expression of key molecular markers, including skeletal muscle and circulating miRNAs, involved in cellular and metabolic pathways' regulation in healthy individuals and in patients suffering from non-communicable diseases (NCDs). Epigenetic factors are emerging as potential therapeutic biomarkers in the prognosis and treatment of NCDs and important epigenetic factors, miRNAs, play a crucial role in cellular pathways. This systematic review aims to underline the potential link between changes in miRNA expression after different types of physical activity/exercise in some populations affected by NCDs. In June 2023, we systematically investigated the following databases: PubMed, MEDLINE, Scopus, and Web of Science, on the basis of our previously established research questions and following the PRISMA guidelines. The risk of bias and quality assessment were, respectively, covered by ROB2 and the Newcastle Ottawa scale. Of the 1047 records extracted from the initial search, only 29 studies were found to be eligible. In these studies, the authors discuss the association between exercise-modulated miRNAs and NCDs. The NCDs included in the review are cancer, cardiovascular diseases (CVDs), chronic obstructive pulmonary disease (COPD), and type 2 diabetes mellitus (T2DM). We evidenced that miR-146, miR-181, miR-133, miR-21, and miRNA-1 are the most reported miRNAs that are modulated by exercise. Their expression is associated with an improvement in health markers and they may be a potential target in terms of the development of future therapeutic tools.
A method, program product, and system for application of an electronic prescription object to food preparation. In an exemplary embodiment, the method includes accessing a prescription object. Further, communications are established between the prescription object and an information repository by use of at least one of a communication network or a server provided by the information repository. Prescription object data is sent to the information repository. The information repository searches for information in response to the prescription object data sent to the information repository by the prescription object. Search information is related to at least one of food preparation or drug and food interactions. Search results are sent to the prescription object from the information repository.
The invention comprises compounds of formula <FORM:0899051/IV (b)/1> wherein R is an alkyl, aryl, alkylaryl or cycloalkyl group which may be substituted, especially by hydroxyl, alkoxy, amino, alkylamino and dialkylamino groups.  They are prepared by reacting 1 : 2 : 4-trihydroxy-benzene with a primary amine R-NH2 in an aqueous medium protected from the air and then isolating the reaction product or a salt formed therefrom by reaction with an inorganic acid.  The compounds are used as hair dyes (see Group IV (c)).  In examples the preparation of 1-cyclohexylamino-, -phenylamino-, -o- or -p-methoxyphenylamino-, -o-, -m- or -p-methylphenylamino-, o- or -p-hydroxyphenylamino-, -methylamino-, -n-pentylamino-, -p-amino- or -dimethylaminophenylamino- and -diethyl-aminoethylamino-2 : 4-dihydroxy-benzenes is described.  The triacetyl derivatives of the first seven compounds listed above are prepared.ALSO:Hair and fur are dyed by impregnating them with an aqueous solution of a compound of the formula <FORM:0899051/IV (c)/1> wherein R is an alkyl, aryl, alkaryl or cycloalkyl group, which may be substituted, especially by hydroxyl, alkoxy, amino, alkylamino and dialkylamino groups (see Group IV (b)), and oxidizing the compound on the fibre.  The oxidation may be effected by atmospheric oxygen, preferably after treatment of the fibre with an alkaline solution, e.g. of ammonia, ammonium carbonate or dimethylamine.  Solutions of oxidising agents such as hydrogen peroxide, a hypochlorite, a bromate, a persulphate or a perborate may also be used to effect the oxidation.  Furs may be mordanted with metals such as copper, iron or chromium before dyeing. Examples of the dyeing processes are given.
Methods and compositions are provided for the treatment and repair of defects or lesions in the cartilage of humans and other animals. The defect or lesion in the cartilage may be first treated with an enzyme to remove proteoglycans from the defect area. To induce cartilage formation, the defect is filled or otherwise dressed with a biodegradable matrix having pores sufficiently large to allow repair cells to populate the matrix. The matrix filling the defect contains a proliferation agent at a concentration sufficient to stimulate proliferation of repair cells and a transforming factor in an appropriate delivery system to release the transforming factor at a concentration sufficient to transform repair cells in the matrix and defect area into cartilage-producing chondrocytes. The matrix may also contain a chemotactic agent to attract repair cells. The entire treatment may be carried out in a single arthroscopic or open surgical procedure.
Patients with β-thalassemia major and transfusion-dependent E-beta THAL. 16 years or older with 10-20 years of chronic transfusion (defined above), 0 to 9 years old at the initiation of chronic transfusions, iron overload documented by either liver biopsy, MRI or SQUID with estimated LIC of greater than 7 mg/g dry wt in the previous 6 months.