anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
This study is a prospective 2-arm parallel controlled trial. The study sites will be conducted in the emergency departments and medical wards of two similar regional general hospitals. It is estimated using GPower that a sample size of 64 participants per group is adequate to detect an effect size of 0.5 on the primary outcomes at a post-intervention time point with 80% power at a 5% level of significance. Participants will be assigned to either an intervention group or a control group. Participants in the intervention group will receive a Mental Health Literacy Program consisting of six 30-minutes online educational sessions and one 60-minutes face-to-face session. No active intervention will be given to the control group. Outcome measures will be measured by the Mental Health Literacy Scale, the Behavioral Health Care Competency survey, the Workplace Stress Scale, and Hospital Patient Satisfaction Survey at baseline, immediately after intervention, and one-month after intervention.
The invention makes available a keratin coating of a support substrate and a method for the production thereof. This keratin coating is suitable particularly for the in vitro or in vivo culturing of epithelial or endothelial cells and, because of its optical transparency, for microscopy. The keratin coating is prepared by applying or coating keratin in the form of nanoparticles from an aqueous keratin solution or keratin suspension. The solution or suspension does not contain any reducing compounds. The keratin solution is prepared preferably from hair, such as human hair. For the preparation of the coating, keratin is brought into solution or into a suspension of nanoparticles by mixing the keratin with an aqueous composition which contains thiourea, urea, and mercaptoethanol.
According to the present invention, a mixed non-liquid skin gel pack is a self-produced customized skin gel pack which is customized in real-time by a purchasing user. The mixed non-liquid skin gel pack comprises a base product. The base product comprises a base composition and a base storage part storing the base composition. The base composition contains a designated base component, is stored in a non-liquid state that can be liquefied, is converted into a liquid state by water in a designated temperature range, and then solidified under designated conditions to become a gel state and be molded into a skin gel pack detachably attached to a designated skin area. When N functional products, in which N (N>=1) functional compositions containing designated functional components are stored in designated N functional storage parts, are prepared, the base composition is put into a designated mixing vessel, into which water within a designated temperature range is introduced, liquefied, and mixed with n (1<=n<=N) functional compositions that are designated by a purchase user from among N compositions corresponding to the N functional products and put into the mixing vessel before, during, or after the liquefaction. According to the present invention, a user can produce a customized skin gel pack optimized for his or her current skin condition.
Embodiments of reduced pressure systems and methods for operating the systems are disclosed. In some embodiments, a system can include a source of negative pressure and a controller configured to present GUI screens for controlling and monitoring operation of the system. The controller can be configured to receive, via the GUI, an adjustment of a negative pressure therapy parameter and adjust (or cause adjustment) of the operation of the negative pressure source based on received adjustment. The controller can be further configured to record historical data parameters associated with negative pressure therapy parameters. The controller can also be configured to transmit (or cause transmission) over a communication channel at least some of recorded historical data. The system can be configured to provide external connectivity for accomplishing various activities, such as location tracking, compliance monitoring, tracking of operational data, remote selection and adjustment of therapy settings, etc.
This non inferiority trial shouts to adress whether the CompuFlo® technology to identify the thoracic epidural space is less efficacious to the gold standard loss of resistance technique (LOR). After informed signed consent patients that will be subjected to gynecological operations and meet the inclusion criteria will be eligible to participate. All operations will be performed under general anesthesia and thoracic epidural analgesia regardless of study arm. Patients will be randomly allocated into two study groups. In the first study group (Group LOR) the thoracic epidural space will be identified by the LOR technique and in the second study group (Group C) by the CompuFlo® technology. The primary outcome is the percentage of thoracic epidural space identification success in either study group.
This study uses a prospective non-randomized, non-controlled design. Five-hundred (500) subjects having previously received a peripheral intravenous therapy will be enrolled into a single treatment group. The purpose of the study is to evaluate the safety, feasibility, and cursory utility of a low-light source integrated into an existing peripheral intravenous catheter. The absence of a control group is based on the following reason: This is a pilot investigation to establish a baseline understanding of the safety, feasibility, and cursory utility of polychromatic light emitting diodes integrated into an existing 20-gauge 1.0 inch peripheral intravascular catheter to improve self-reported overall subject energy levels based on the change in Epworth Sleepiness scores.

Peripheral intravascular therapy has been used for decades as an effective therapy to maintain proper hydration and electrolyte levels, and has been deemed a non-significant medical procedure. Peripheral intravascular therapy can be infused with various molecular agents such as supplements (Vitamin B12) for the purpose of improving energy levels and overall quality of life. However, the use of normal saline as a standard alone helps improve hydration and cell function. Low-energy light therapy has been established as an alternative treatment for a myriad of medical conditions. Light-based therapy stimulates photoreceptors found within cells and can improve overall cellular bioenergetics. The concurrent administration of low-light therapy and peripheral intravascular normal saline therapy may serve as a viable therapy for the treatment for improvement in subject quality of life and energy levels Accordingly, this study is designed to assess the safety, feasibility, and cursory improvement in self-reported energy levels following intervention of low-light therapy integrated into a standard peripheral intravascular catheter.
No cases of overdose have been reported with BEVESPI AEROSPHERE. BEVESPI AEROSPHERE contains both glycopyrrolate and formoterol fumarate; therefore, the risks associated with overdosage for the individual components described below apply to BEVESPI AEROSPHERE. Treatment of overdosage consists of discontinuation of BEVESPI AEROSPHERE together with institution of appropriate symptomatic and/or supportive therapy. The judicious use of a cardioselective beta-receptor blocker may be considered, bearing in mind that such medication can produce bronchospasm. Cardiac monitoring is recommended in case of overdosage.

Glycopyrrolate

High doses of glycopyrrolate, a component of BEVESPI AEROSPHERE, may lead to anticholinergic signs and symptoms such as nausea, vomiting, dizziness, lightheadedness, blurred vision, increased intraocular pressure (causing pain, vision disturbances or reddening of the eye), obstipation or difficulties in voiding. 

Formoterol Fumarate

An overdose of formoterol fumarate would likely lead to an exaggeration of effects that are typical for beta2-agonists: seizures, angina, hypertension, hypotension, tachycardia, atrial and ventricular tachyarrhythmias, nervousness, headache, tremor, palpitations, muscle cramps, nausea, dizziness, sleep disturbances, metabolic acidosis, hyperglycemia, hypokalemia. As with all sympathomimetic medications, cardiac arrest and even death may be associated with overdosage of formoterol fumarate.
PURPOSE:To produce the titled substance which is a simple substance separated from T-leukemia cell strain, inducing the expression of interleukin 2 receptor and useful for the remedy of immunoinsufficiency, cancer and autoimmune infectious diseases. CONSTITUTION:The expression-inducing substance (abbreviated as ADF) for interleukin 2 receptor has the following characteristics. Molecular weight, 20-10Kd (Sephacryl-S200 gel-filtration); isoelectric point, pI 5.5-4.5; amino acid sequence (from N-terminal), shown in the formula. ADF has been found in a supernatant liquid of the cultured T-leukemia cell strain (ATL cell) established from a human adult-type T-leukemia patient. Although known ADF fraction is a mixture of several proteins, the ADF of the present invention corresponds to the simple substance having lower molecular weight in two ADF activity peaks obtained by the fractionation of a concentrated ATL cell liquid using a Sephacryl S-200 column. The ADF can be used as a remedy singly or in combination with IL2 or other lymphokine.
Basketball is a sport that changes very fast and quickly on the court and involves being always ready and mobile to pass, shoot, dribble or rebound. Some performance-related physical fitness parameters of basketball are: speed, flexibility, endurance, body composition, strength, agility, coordination. Some performance-related physical fitness parameters of basketball are: speed, flexibility, endurance, body composition, strength, agility, coordination.As a result of the high thrust forces generated during jumping and the eccentric forces applied to the lower body during landing, these athletes place great stress on their ankles and knees and require a high degree of force application and the ability to safely control eccentric landing forces.These functional changes are mainly controlled by the lower limbs, but lower limb control is influenced by range of motion, which affects flexibility when strength is reduced." It is easy to see why flexibility is so important for effective basketball sport efficiency.Flexibility is important in both prevention and rehabilitation of musculoskeletal injuries. When looking at sports performance, the hamstring and gastrocnemius muscles have a fundamental role in the myofascial chain defined by Myers. Myofascial release is a series of manual therapy techniques that involve applying pressure to soft tissue (fascia) to achieve structural and mechanical adaptation.The therapist applies a continuous, slow and steady pressure on the restricted tissue barrier and when the tissue relaxes, a new tissue barrier is applied.While continuous pressure applied to fascia tissue is called direct treatment and traction applied is called indirect treatment, another treatment method is self-myofascial release. Self-Myofascial Release (SMR) is performed by applying pressure on restricted fascia tissue using various materials and one's own body weight in different body positions. The material used can be foam roller, vibrating foam roller.
PURPOSE: A complex containing cyclodextrin or cyclodextrin derivative and low molecular halogenated ether is provided to enable controlled release of narcotic and to be used as a somnifacient. CONSTITUTION: A complex contains cyclodextrin or cyclodextrin derivative and low molecular halogenated ether mixed in a ratio of 1:1, 2:1, or 3:1. The halogenated ether has 4 or less of carbon atoms and is sevoflurane, isoflurane, or desflurane. The cyclodextrin is alpha, beta, or gamma-cyclodextrin. The cyclodextrin is methyl, sulfobutyl ether, and hydroxypropyl derivative of the alpha, beta, or gamma cyclodextrin. A method for preparing the complex comprises: a step of mixing an aqueous formulation and halogenated ether in a ratio of 4:1-35:1; a step of charging the aqueous formulation; and a step of adding halogenated ether. A pharmaceutical composition contains the complex and is manufactured in the form of tablet, coated tablet, or aqueous formulation.
The urine albumin (Alb)-to-creatinine (Crn) ratio (UACR) is a sensitive and early indicator of chronic kidney disease (CKD) and cardiorenal syndrome. This study developed a portable and wireless electrochemical-sensing platform for the sensitive and accurate determination of UACR. The developed platform consists of a carbon nanotube (CNT)-2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)(ABTS)-based modified UACR sensor, a miniaturised potentiostat, a cup holder embedded with a magnetic stirrer and a smartphone app. The UACR sensing electrode is composed of two screen-printed carbon working electrodes, one screen-printed carbon counter electrode and a screen-printed AgCl reference electrode. The miniaturised potentiostat, which is controlled by the developed app, performs cyclic voltammetry and amperometry to detect Alb and Crn, respectively. Clinical trials of the proposed system by using spot urine samples from 30 diabetic patients indicate that it can accurately classify all three CKD risk statuses within 30 min. The high accuracy of our proposed sensing system exhibits satisfactory agreement with the commercial biochemical analyser TBA-25FR (Y = 0.999X, R2 = 0.995). The proposed UACR sensing system offers a convenient, reliable and affordable solution for personal mobile health monitoring and point-of-care urinalysis.
The patient will be placed in the lateral decubitus position according to the selected site of surgical intervention. After sterilization of the skin and draping, the high frequency linear probe of Sonosite M Turbo ultrasonography ( FUJIFIM sonosite, Inc., Bothell, WA, USA) will be placed horizontally midway between tip of the scapula and posterior axillary line to identify the view of latissimus dorsi(lying superficial) and serratus anterior muscle(lying deep) over either the sixth or seventh rib. A 22-gauge, 80 mm needle (Stimuplex D, B-Braun, Germany) will be inserted in plane relative to the ultrasound probe from posteromedial to anterolateral direction toward posterior axillary line till reaching the interfacial plane between latissimus dorsi and serratus anterior muscle . After confirming negative aspiration of blood, 1 ml normal saline will be injected for hydro-dissection sign to verify the needle tip, then a volume of 25 ml 0.25% bupivacaine will be injected .
XELOX / Bevacizumab will be administrated for 3 cycles over a 9 week period. XELOX without Bevacizumab will be administrated for an additional cycle over a 4 week period. Patients will undergo re-staging within 3 weeks of their 4th cycle of XELOX. This will include MRI of the pelvis. If the reassessment reveals that there has been no disease progression compared to the pre-treatment evaluation and the patient remains a candidate for an R0 resection, the patient will proceed to definitive rectal cancer surgery within 4 weeks from the last chemotherapy dose. If the surgical oncologist's reassessment reveals that the patient is not a candidate for an R0 resection, the patient will proceed to standard pre-operative radiation with synchronous Capecitabine.
Treatment of patients with ISR remains a challenge. Currently both drug-eluting stents (DES) and drug-coated balloons (DCB) are considered as the strategies of choice in this setting. However, data on the value of BVS in patients with ISR is scarce. BVS are very effective to inhibit neointimal proliferation and they avoid the need of implanting a new permanent metal layer. Accordingly, currently, there is a major interest to elucidate the potential value of BVS in patients with ISR.

This prospective Spanish multicenter study will assess the clinical and angiographic outcome of patients with ISR treated with BVS. BVS will be implanted in selected patients (fulfilling inclusion and exclusion criteria) presenting with either BMS-ISR or DES-ISR. Care will be paid to ensure device optimization. Angiographic follow-up will be obtained at 6-9 months. A centralized angiographic corelab will be used to provide QCA measurements. Clinical follow-up will be also obtained at 1 year and then yearly. Clinical events will be adjudicated by an independent Clinical Event Committee.
The object of the present invention is to create a novel indazole derivative having spirocyclic structure in the side chain which is useful as a medicament and to find out novel pharmacological effect of the derivative. The compound of the present invention has the excellent Rho kinase inhibiting activity and has the following formula [I], (wherein, cyclic X represents a benzene ring or a pyridine ring; R1 and R2 each represents a halogen atom, a hydrogen atom, a hydroxyl group, an alkoxy group, a cycloalkoxy group, an aryloxy group, an alkyl group, a cycloalkyl group etc,; R3 represents a halogen atom, a hydrogen atom etc.; R4 and R5 each represents a halogen atom, a hydrogen atom etc.; R6 and R7 each represents a hydrogen atom, an alkyl group etc.; m, n, p and q each represents an integer of 0 to 3. Each group maybe optionally substituted.
HS applied to a newborn baby makes the baby feel completely safe, as if in the womb. After laying the soft fabric or baby blanket, it was placed in the supine position. Half swaddling was done so as not to restrict the baby's arm and leg movements. HS was performed 15 minutes before each sleep during the day until the 3rd month.The application was applied at twice a day and for 60 min, every day for 6 months in a row. During KC, the mother placed her baby between two breasts, and the baby's breast was placed on the mother's breast in an upright position. During the application of KC, a quiet, calm and suitable environment was created so that comfort of the baby and mother would not be disturbed. The mother and baby are covered with a blanket. In the continuation of the KB application, the mother was asked to breastfeed her baby.
The control of bacterial growth is key to the prevention and treatment of tuberculosis (TB). Granulomas represent independent foci of the host immune response that present heterogeneous capacity for control of bacterial growth. At the whole tissue level, B cells and CD4 or CD8 T cells have an established role in immune protection against TB. Immune cells interact within each granuloma response, but the impact of granuloma immune composition on bacterial replication remains unknown. Here we investigate the associations between immune cell composition, including B cell, CD4, and CD8 T cells, and the state of replicating Mycobacterium tuberculosis (Mtb) within the granuloma. A measure of ribosomal RNA synthesis, the RS ratio®, represents a proxy measure of Mtb replication at the whole tissue level. We adapted the RS ratio through use of in situ hybridization, to identify replicating and non-replicating Mtb within each designated granuloma. We applied a regression model to characterize the associations between immune cell populations and the state of Mtb replication within each respective granuloma. In the evaluation of nearly 200 granulomas, we identified heterogeneity in both immune cell composition and proportion of replicating bacteria. We found clear evidence of directional associations between immune cell composition and replicating Mtb. Controlling for vaccination status and endpoint post-infection, granulomas with lower CD4 or higher CD8 cell counts are associated with a higher percent of replicating Mtb. Conversely, changes in B cell proportions were associated with little change in Mtb replication. This study establishes heterogeneity across granulomas, demonstrating that certain immune cell types are differentially associated with control of Mtb replication. These data suggest that evaluation at the granuloma level may be imperative to identifying correlates of immune protection.
Subjects undergoing anterior cruciate ligament surgery will be randomized to receive 20 mL of ropivacaine 0.5% in the adductor canal. Subjects will also receive standard of care Percocet 7.5/325 and naprosyn following surgery.
A compound isolated from Antrodia camphorate is provided for producing anticancer pharmaceutical drugs in order to inhibit growth of cancer cells such as breast cancer, lung cancer, liver cancer and prostate cancer. A compound isolated from Antrodia camphorate has a structure represented by the formula 1. In the formula 1, x is a hydroxyl(-OH) or methoxy(-OCH3) group. If the x represents the hydroxyl group, the compound is antroquinonol B. If the x represents the methoxy group, the compound is antroquinonol C. The compound inhibits growth of cancer cells associated with breast cancer, lung cancer, liver cancer and prostate cancer. The breast cancer cell is selected from the group consisting of breast cancer cell strain MCF-7 and breast cancer cell strain MDA-MB-231.
The intervention administered in this study is ADAS-integrated driver simulation training. Participants in this arm will undergo training sessions using a high-fidelity driving simulator equipped with Lane Departure Warning (LDW), Cruise Control (CC), and Forward Proximity Warning (FPW) technologies. These technologies are designed to assist older drivers (≥65 years of age) in improving their driving performance and reducing critical driving errors. The training will simulate real-world driving scenarios to help participants become familiar with and effectively use these ADAS features.
Oligonucleotides directed against the hypoxia-inducible factor-l.alpha.. (HIF-1.alpha.)- gene are provided for modulating the expression of HIF-1.alpha.. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the HIF-1.alpha.. Methods of using these compounds for modulation of HIF-1.alpha.. expression and for the treatment of diseases associated with the hypoxia-inducible factor-1.alpha. are provided. Examples of diseases are cancer and pre-eclampsia. The oligonucleotides may be composed of deoxyribonucleosides, a nucleic acid analogue, or Locked Nucleic Acid (LNA) or a combination thereof.
OBJECTIVE: To evaluate the efficacy of erector spinae plane block (ESPB) on intraoperative hemodynamic stability, opioid and inhalation anesthetic requirements and postoperative analgesic effects in patients undergoing surgical stabilization of rib fractures (SSRFs).
METHODS: We retrospectively reviewed 173 patients who underwent surgical stabilization of rib fractures between May 2020 and December 2023. The patients were allocated into the ESPB group or the control group. Demographic data, intraoperative hemodynamic parameters, total intraoperative opioid consumption, the average minimum alveolar concentration (MAC) of inhalational anesthetics, postoperative simple analgesics and opioid consumption and the length of hospital stay were included in the analysis.
RESULTS: Compared with the control group, the ESPB group had a lower heart rate (HR) in the first 90 min after surgical incision and lower systolic blood pressure (SBP) and mean arterial pressure (MAP) at the beginning of surgery. Intraoperatively, a notable reduction in fentanyl consumption was observed in the ESPB group (p = 0.004), whereas no significant difference was observed in the average MAC of inhalational agents (p = 0.073). Postoperatively, the ESPB group required fewer doses of simple analgesics in the first 24 h (p < 0.001) and 48 h (p = 0.029). No statistically significant difference in the length of hospital stay (p = 0.608) was observed between the groups.
CONCLUSION: ESPB was shown to enhance intraoperative hemodynamic stability, reduce opioid consumption and decrease postoperative analgesic consumption in patients who underwent SSRF. These results suggest that ESPB may serve as a valuable component of multimodal analgesia protocols for SSRF. Larger prospective studies are warranted to confirm the results and evaluate long-term outcomes.