anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
BACKGROUND: About 15% to one third of migraineurs experience aura symptoms. Aura is a reversible focal neurological phenomenon involving visual, sensory, speech, and motor symptoms that usually precede migraine pain. Monoclonal antibodies against calcitonin-related peptide (anti- CGRP mAbs) are effective in preventing chronic and episodic migraine, but little is known about their effectiveness on specifically preventing migraine with aura.
METHODS: This is a pilot prospective observational cohort study, aiming at evaluating the effectiveness and safety of Erenumab, Fremanezumab or Galcanezumab for the treatment of migraine aura. We enrolled 14 patients at the Headache Centre of University Federico II of Naples. Duration of follow-up was 12 months. We assessed mean monthly days with aura symptoms, with or without subsequent headache, as well as mean monthly days with headache and mean monthly MIDAS score, by reviewing standardized paper patient headache diaries every three months.
RESULTS: A significant decrease in mean monthly aura days was observed throughout the observation period (median baseline: 13, interquartile range: 4-16; after 12 months: 1, interquartile range: 0-3, p < 0.001). We observed a statistically significant decrease in mean monthly headache days as well (median baseline 21, interquartile range: 16-30; after 12 months: 5, interquartile range: 4-7, p < 0.001). During the 12-month treatment period, none of the 14 patients reported mild or serious adverse events.
CONCLUSION: Our findings suggest that anti-CGRP mAbs are highly effective in migraine with aura, both in reducing mean monthly aura days and mean monthly days with headache.
FIELD: biotechnology. SUBSTANCE: method involves the cultivation of one of microorganism strain Streptomyces thermoarchaensis NCIB 12015, 12111, 12112, 12113 or 12114 under aerobic condition at 20-50 C and pH 5.5-8.5 for at least 2 days. Antibiotic is isolated from cultural fluid. Antibiotic formula is given in invention description. Antibiotic is purified by chromatography method if necessary. The end product shows antihelminthic activity. EFFECT: improved method of antibiotic preparing.
Pregnancy is associated with neural and behavioral plasticity, systemic inflammation, and oxidative stress, yet the impact of inflammation and oxidative stress on maternal neural and behavioral plasticity during pregnancy is unclear. We hypothesized that healthy pregnancy transiently reduces learning and memory and these deficits are associated with pregnancy-induced elevations in inflammation and oxidative stress. Cognitive performance was tested with novel object recognition (recollective memory), Morris water maze (spatial memory), and open field (anxiety-like) behavior tasks in female Sprague-Dawley rats of varying reproductive states [nonpregnant (nulliparous), pregnant (near term), and 1-2 mo after pregnancy (primiparous); n = 7 or 8/group]. Plasma and CA1 proinflammatory cytokines were measured with a MILLIPLEX magnetic bead assay. Plasma oxidative stress was measured via advanced oxidation protein products (AOPP) assay. CA1 markers of oxidative stress, neuronal activity, and apoptosis were quantified via Western blot analysis. Our results demonstrate that CA1 oxidative stress-associated markers were elevated in pregnant compared with nulliparous rats (P ≤ 0.017) but there were equivalent levels in pregnant and primiparous rats. In contrast, reproductive state did not impact CA1 inflammatory cytokines, neuronal activity, or apoptosis. Likewise, there was no effect of reproductive state on recollective or spatial memory. Even so, spatial learning was impaired (P ≤ 0.007) whereas anxiety-like behavior (P ≤ 0.034) was reduced in primiparous rats. Overall, our data suggest that maternal hippocampal CA1 is protected from systemic inflammation but vulnerable to peripartum oxidative stress. Peripartum oxidative stress elevations, such as in pregnancy complications, may contribute to peripartum neural and behavioral plasticity.NEW & NOTEWORTHY Healthy pregnancy is associated with elevated maternal systemic and brain oxidative stress. During postpregnancy, brain oxidative stress remains elevated whereas systemic oxidative stress is resolved. This sustained maternal brain oxidative stress is associated with learning impairments and decreased anxiety-like behavior during the postpregnancy period.
The invention relates to a compound medicine for treating autoimmunity thrombocytopenic purpura. The compound medicine comprises effective ingredients and adjuvant ingredients, wherein the effective ingredients are prepared from the following components in parts by weight: 6-12 parts of processed Rehmannia glutinosa, 10-20 parts of Rehmannia glutinosa, 10-25 parts of Gynura japonica, 10-20 parts of Scrophularia ningpoensis, 9-15 parts of Scutellaria baicalensis, 5-10 parts of Forsythia suspensa, 12-15 parts of Cirsium setosum and 9-15 parts of Gardenia jasminoides fruit. The adjuvant ingredients are prepared from the following components in parts by weight: 9-15 parts of Sophora tonkinensis root,10-15 parts of Cortex Lycii (Lycium chinense and/or Lycium barbarum), 30-60 parts of Imperata cylindrica root, 5-10 parts of Monochasma sheareri, 10-20 parts of Bubalus bubalis horn, 6-12 parts of Alisma orientalis, 10-15 parts of Rubia cordifolia, 6-12 parts of Angelica sinensis, and 6-15 parts of Paeonia suffruticosa root bark. The components of the effective ingredient and the adjuvant ingredient are reasonably compounded to take synergistic effect. Chinese medicinal materials with effects of eliminating pathogenic heat from the blood and promoting blood circulation are used. The compound medicine can be used for treating autoimmunity thrombocytopenic purpura and has the advantages of quick action, stable therapeutic effect, and so on.
Participants received mobile phone delivered intervention at enrollment. The intervention had a duration of 4 weeks. Each week participants received two text messages inviting them to view a short video (Monday) and brief written content (Wed). Each week, the material consisted of a culturally tailored theme related to COVID-19 vaccination. Participants also received information on how to get vaccinated.
This group will receive peritonitis treatment placed in Automated Peritoneal Dialysis. The initial antibiotic scheme will be with ceftazidime (1500mg/day) and vancomycin (20mg/kg every 3 days); adjusting the management according to the result of the culture, completing the antibiotic scheme for 14 to 21 days.
PURPOSE: A composition containing Diospyros blancoi A. DC. extract or fraction thereof is provided to prevent and delay aging. CONSTITUTION: A cosmetic composition for anti-aging contains Diospyros blancoi A. DC. extract or fraction thereof as an active ingredient. The extract is prepared using water, low carbon number alcohol, or a mixture solvent thereof. The fraction is prepared by fractioning the extract with n-hexane, chloroform, ethyl acetate, n-butanol, and water in order. A pharmaceutical composition for anti-aging contains the extract or fraction as an active ingredient. A health functional food composition for anti-aging contains the extract or fraction as an active ingredient.
AIM: Assess the prognostic ability of a non-highly malignant and reactive EEG to predict good outcome after cardiac arrest (CA).
METHODS: Prospective observational multicentre substudy of the "Targeted Hypothermia versus Targeted Normothermia after Out-of-hospital Cardiac Arrest Trial", also known as the TTM2-trial. Presence or absence of highly malignant EEG patterns and EEG reactivity to external stimuli were prospectively assessed and reported by the trial sites. Highly malignant patterns were defined as burst-suppression or suppression with or without superimposed periodic discharges. Multimodal prognostication was performed 96 h after CA. Good outcome at 6 months was defined as a modified Rankin Scale score of 0-3.
RESULTS: 873 comatose patients at 59 sites had an EEG assessment during the hospital stay. Of these, 283 (32%) had good outcome. EEG was recorded at a median of 69 h (IQR 47-91) after CA. Absence of highly malignant EEG patterns was seen in 543 patients of whom 255 (29% of the cohort) had preserved EEG reactivity. A non-highly malignant and reactive EEG had 56% (CI 50-61) sensitivity and 83% (CI 80-86) specificity to predict good outcome. Presence of EEG reactivity contributed (p < 0.001) to the specificity of EEG to predict good outcome compared to only assessing background pattern without taking reactivity into account.
CONCLUSION: Nearly one-third of comatose patients resuscitated after CA had a non-highly malignant and reactive EEG that was associated with a good long-term outcome. Reactivity testing should be routinely performed since preserved EEG reactivity contributed to prognostic performance.
BACKGROUND: Malignant phyllodes tumor (MPT) is a rare breast disease that is extremely rare in children. A few cases of pediatric malignant phyllodes tumors have been reported, including some with a poor prognosis.
CASE: A 14-year-old girl presented with a growing lump on her right breast. On the basis of imaging tests and a core needle biopsy, MPT was diagnosed, and right mastectomy was performed. The postoperative course was uneventful.
SUMMARY AND CONCLUSION: MPT is an infrequent disease in adult females and is extremely rare in pubertal females. It occasionally shows rapid growth, metastasis, and recurrence with a poor prognosis. Early surgical resection is necessary to obtain a cure. When a rapidly growing breast tumor is observed in pubertal females, MPT should be considered.
The mode of conventional PDF treatment group is CVVHDF in CRRT machine, and the duration of treatment is 3 hours. the application plasma volume 1500 ml . The replacement fluid flow rate is 500 ml/h, the dialysate flow rate is 3000 ml/h, the blood flow rate is 100-140 ml/min, and the ultrafiltration volume is 0 ml/h.
PURPOSE:To obtain a pharmaceutical for treating and preventing liver functional disease of domestic animal and livestock e. g., capable of lowering liver lipid content, liver triglyceride content and fatty hepatic score and suppressing occurrence of fatty liver of a domestic fowl, by containing a vegetable sterol as an active ingredient. CONSTITUTION:A vegetable sterol is contained as an active ingredient. As the vegetable sterol, e. g., stigmasterol obtained from soybean, coconut, cotton seed, bean, arrowhead, etc.; campesterol obtained from notch, wheat, soybean, rye, etc.; beta-sitosterol contained as glycoside, fatty acid ester, etc., in liberated state in bark, leaf, etc., of cereals or higher plant or gamma-sitosterol obtained from pea, carabal bean, etc., is used. When used, the vegetable sterol may be directly blended with a feed ingredient or the vegetable sterol dispersed in a diluent may be added to the feed ingredient, etc.
PURPOSE:To provide the titled growth accelerator containing growth hormone and/or prolactin of fish, utilizable for the proliferation of artificial seeds of shellfish and useful in the shellfish culture industry. CONSTITUTION:The objective shellfish growth accelerator contains a growth hormone and/or prolactin of fish (a metabolic hormone extracted from the pituitary gland of salmon, eel, etc., or obtained by integrating a gene coding the above compound into a bacterial cell of e.g. E.coli using a recombinant DNA technique and culturing the resultant transformation; molecular weight, about 20,000-30,000; number of amino acid residues, 180-190). The growth of shellfish (e.g. snails such as ear-shell, top shell, tokobushi abalone, etc., or bihalves such as hard clam, short-necked clam, ark shell, etc.) can be accelerated by immersing the shellfish in a solution of the agent or adding the agent to the feed for the shellfish. The immersion is carried out at a concentration of 0.5-50mg/l at <= 5 deg.C for 5min - 24hr once every 3-7 days from 30 days old shellfish to the end of growth.
The research team will take a reflectance measurement on the same location that the most recent pulse oximetry measurement was taken. In addition, a reflectance measurement will be taken bilaterally for the nailbed, dorsal and ventral side of the digits, dorsal and ventral side of the hand, dorsal and ventral side of the forearm, lower leg, foot, and either side for the ear. The most recent pulse oximetry and arterial oxygen saturation readings will be accessed through the electronic medical records, those readings are generally conducted simultaneously and will provide comparison. The duration anticipated for an individual participant's participation is 1 day.
Coagulation tests

TAKHZYRO can increase activated partial thromboplastin time (aPTT) due to an interaction of TAKHZYRO with the aPTT assay. The reagents used in the aPTT laboratory test initiate intrinsic coagulation through the activation of plasma kallikrein in the contact system. Inhibition of plasma kallikrein by TAKHZYRO can increase aPTT in this assay. In Trial 1, prolongation of aPTT (>1× ULN) was observed at one or more time points in 3, 9, and 11 patients treated with TAKHZYRO 150 mg q4wks, 300 mg q4wks, and 300 mg q2wks, respectively, compared to 5 placebo-treated patients. Only one patient in the 300 mg q2wks treatment group experienced transient aPTT prolongation ≥1.5x ULN which was confounded by ongoing heparin therapy. None of the increases in aPTT in patients treated with TAKHZYRO were associated with abnormal bleeding adverse events. There were no differences in INR values between treatment groups.
A 61-year-old woman was administered 35 cycles of pembrolizumab for the treatment of recurrent endometrial cancer, achieving a complete response. She presented with asymptomatic pancreatic enlargement and elevated hepatobiliary enzymes, but amylase and lipase levels were within the normal ranges. Intrapancreatic bile duct stenosis due to pancreatic enlargement was present, mimicking autoimmune pancreatitis on computed tomography performed before the onset of clinical manifestations. A histological examination of a biopsy specimen showed lymphocyte and plasma cell infiltration with dense fibrosis in the stroma. The patient was successfully treated with oral prednisolone. There were no manifestations of recurrent pancreatitis after tapering the prednisolone dose.
The present disclosure provides a process for the preparation of ixazomib citrate. An efficient, industrially feasible process for the preparation of ixazomib citrate of Formula I, optionally which the process can occur in a single pot.The present disclosure provides a process for the preparation of ixazomib citrate. An efficient, industrially feasible process for the preparation of ixazomib citrate of Formula I, optionally which the process can occur in a single pot. An illumination system is provided that includes a light source configured to emit a first handedness polarization of light onto a body, the first handedness polarization of light having at least one of a circular and an elliptical polarization. The body reflects a second handedness polarization of light. An optical filter is configured to at least one of absorb and reflect the second handedness polarization of light and transmit the first handedness polarization of light.
Colorectal polyp diagnosis is based on endoscopic resection and histological analysis. An accurate optical diagnosis could avoid histological lesion of smaller lesions, reducing the costs associated with histological diagnosis. However, it should be noted this policy could only be applied in diminutive polys considering high proposition of advanced adenomas in polyps more than 5 mm. In addition, optical diagnosis criteria of advanced adenomas have not been validated for finding advanced adenomas among adenoma polyps. If as many as advanced adenomas as possible could be differentiated from non-advanced adenomas and be further sent for histological examination, this policy could be generalized to small polyps.

Considering this situation, the investigators tried to develop computer-aided optical dignosis of advanced adenoma using non-magnified NBI image with preliminary, satisfied results. In this study, the investigators next validate the investigators' developed computer-aided system for detecting advanced adenomas by comparing endoscopists' optical detection of advanced adenomas with or without the investigators' computer-aided system.
This study investigated the role of Poly (ADP-ribose) Polymerase (PARP) in myocardial ischemia-reperfusion injury (MIRI) in elderly mice. It involves 30 elderly male KM mice divided into three groups: Sham, MIRI, and DPQ, where the MIRI and DPQ groups undergo myocardial ischemia-reperfusion with the DPQ group also receiving DPQ for PARP-1 inhibition. Over three weeks, assessments include histological analysis of myocardial lesions, left ventricular ejection fraction (LVEF) measurements, and evaluations of serum cardiac enzymes and inflammatory markers. This approach aims to understand the protective effects of DPQ in MIRI, focusing on its impact on cardiac health and inflammation via the JAK2/STAT3 pathway. The findings suggest that PARP activation exacerbates cardiac dysfunction and inflammation in MIRI by possibly modulating the JAK2/STAT3 signaling pathway. Inhibition of PARP-1 with DPQ mitigates these effects, as indicated by reduced myocardial lesions and inflammatory infiltration, improved LVEF, and altered levels of inflammatory markers and signaling molecules. However, the differences in STAT3 and p-STAT3 protein expression between the DPQ and MIRI groups were not statistically significant, suggesting that while PARP inhibition affects many aspects of MIRI pathology, its impact on the JAK2/STAT3 pathway may not fully explain the observed benefits. This study contributes to our understanding of the complex mechanisms underlying myocardial ischemia-reperfusion injury, particularly in the context of aging. It highlights the potential of PARP inhibition as a therapeutic strategy to attenuate cardiac dysfunction and inflammation in MIRI, though further research is necessary to fully elucidate the underlying molecular pathways and to explore the clinical relevance of these findings in humans.
The invention discloses a preparation method of novel compound antibacterial peptide, novel compound antibacterial peptide and application thereof. The novel composite antibacterial peptide is connected with n-decanoic acid through solid phase synthesis on the basis of the original antibacterial peptide. The interaction of the novel complex antibacterial peptide with DNA was studied by fluorescence spectroscopy. The minimum inhibitory concentration of the novel complex antimicrobial peptides against various bacteria was determined using a micro broth dilution method. The novel compound antibacterial peptide has a minimum antibacterial concentration of 7.81 mug/mL for escherichia coli, a minimum antibacterial concentration of 3.91 mug/mL for listeria, a minimum antibacterial concentration of 3.91 mug/mL for staphylococcus aureus and a minimum antibacterial concentration of 7.81 mug/mL for shigella flexneri. The novel compound antibacterial peptide has very good broad-spectrum antibacterial activity. And has no influence on the proliferation of mammal cells and cell morphology under the condition of minimum antibacterial concentration.
ARM D: WBRT with 36 Gy in the case of CR to primary chemotherapy or the same WBRT dose followed by a tumor-bed boost of 9 Gy with 1-2 cm of margin surrounding enhanced residual lesion (total tumor-bed dose 45 Gy) in patients who achieved a PR or SD after primary chemotherapy. Photons of 4-10 Mev, 180 cGy per day, 5 weekly fractions.
The diagnosis of bloodborne viral infections (viremia) is currently relegated to central laboratories because of the complex procedures required to detect viruses in blood samples. The development of point-of-care diagnostics for viremia would enable patients to receive a diagnosis and begin treatment immediately instead of waiting days for results. Point-of-care systems for viremia have been limited by the challenges of integrating multiple precise steps into a fully automated (i.e., sample-to-answer), compact, low-cost system. We recently reported the development of thermally responsive alkane partitions (TRAPs), which enable the complete automation of diagnostic assays with complex samples. Here we report the use of TRAPs for the sample-to-answer detection of viruses in blood using a low-cost portable device and easily manufacturable cassettes. Specifically, we demonstrate the detection of SARS-CoV-2 in spiked blood samples, and we show that our system detects viremia in COVID-19 patient samples with good agreement to conventional RT-qPCR. We anticipate that our sample-to-answer system can be used to rapidly diagnose SARS-CoV-2 viremia at the point of care, leading to better health outcomes for patients with severe COVID-19 disease, and that our system can be applied to the diagnosis of other life-threatening bloodborne viral diseases, including Hepatitis C and HIV.
Topical insulin (Humulin R) will be compounded under sterile conditions at a local pharmacy at a concentration of 25 IU / ml in sterile balanced saline solution (0.9%). Topical insulin will be administered four times per day to the affected eye. A bottle of topical insulin can be used for 14 days. Any remaining topical insulin will be discarded as waste after 14 days.
The present invention relates to an anti-cancer medicine composition containing chemotherapeutic synergist. Said anti-cancer medicine composition is a slow-release injection formed from slow-release microsphere and solvent. Said slow-release microsphere includes anti-cancer effective component and slow-release auxiliary material, and its solvent is a special solvent containing suspension adjuvant. The anti-cancer effective component is the combination of alkylation agent, purine analogues and/or hormones anti-cancer medicine and synergist, the slow-release auxiliary material is selected from one of polylactic acid and its copolymer, polylactic acid copolymer or mixture and sebacic acid or their combination. The suspension adjuvant is selected from carboxymethyl cellulose, etc. and its viscosity is 80 cp-3000 cp. Said medicine composition also can be made into slow-release implantation preparation.
Alzheimer's disease (AD), a neurodegenerative disorder characterized by cognitive impairment and a suspected dementia syndrome, is the most common type of dementia (\>50% of all cases), affecting millions worldwide, with no cure available at this time. Definite AD diagnosis currently relies on the post-mortem observation of the hallmarks β-amyloid peptides (Aβ) extracellular aggregates, Aβ plaques, and protein tau intracellular twisted strands (neurofibrillary tangles, NFTs). Earlier diagnosis could dramatically transform the design and execution of clinical trials to test new treatments. The eye offers a natural window to the brain as the retina, the light sensitive layer lining the interior of the eye is an extension of the brain. The presence of Aβ plaques in the retina of AD mice models and humans was recently reported opening the possibility of detecting this AD hallmark though a simple non-invasive eye scan. The proposed research aims to explore this avenue with the development of a spectrally-resolved optical retinal imaging platform to detect Aβ plaques in the retina of AD subjects and validate the method against brain Aβ plaques seen on amyloid PET imaging. The novel imaging platform is expected to help aid the early detection of AD and assist in monitoring efficacy of possible future therapeutic agents that target relevant molecular pathways.