anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Nitroxyl is used to inhibit COX-2 activity and particularly to selectively inhibit COX-2 activity. Nitroxyl also is used to treat conditions that respond favorably to inhibition of COX-2 activity in subjects having such conditions. In some cases nitroxyl is used to treat conditions that respond favorably to inhibition of COX-2 activity in subjects having such conditions and who also have at least one other condition for which inhibition of COX-1 activity is disadvantageous.  
     Nitroxyl can be provided directly, but typically is provided with the use of a nitroxyl donor. Nitroxyl donors include any agent or compound (or combination thereof) that donates HNO or NO − . Diazeniumdiolates are used in some cases as nitroxyl donors. In particular instances, diazeniumdiolates having a primary amine group are used as nitroxyl donors. Nitroxyl-donating compounds also are screened for selective COX-2 inhibition for identification as therapeutic agents.
Cognitive Processing Therapy is a \~12 session trauma-focused therapy that teaches cognitive restructuring skills to help clients change beliefs and process emotions related to a specific traumatic event, which can be generalized to other traumatic experiences as well as everyday stressors. After initial psychoeducation and practice with cognitive restructuring skills, patients use skills to identify and challenge maladaptive beliefs about the traumatic event itself as well as those related to five themes thought to be affected by trauma-safety, trust, power, control, esteem, and intimacy.
OBJECTIVES: Obesity is a risk factor for chronic diseases. The prevalence of obesity is rapidly increase and a significant social inequality exists. This study aimed to analyse obesity prevalence and complications in different regions and occupations in China.
STUDY DESIGN: Multicentre cross-sectional study.
METHODS: Data from 62,893 adults in 10 Chinese provinces were collected in 2022. Measures included body mass index (BMI), metabolic status and complications. Analysis was stratified by gender, age, region and occupation, with results adjusted for age and gender.
RESULTS: The average BMI was 23.81 ± 3.42 kg/m2, with overweight and obesity prevalence at 34.29 % and 11.24 %, respectively. North China had the highest obesity rate (27.93 %), followed by West (26.64 %), South (25.37 %) and East China (20.06 %). Functionaries (e.g. as civil servants, corporate executives) had higher BMI than employees or intellectual professionals, while workers had higher BMI than farmers. Intellectual professionals had the lowest rates of metabolically healthy obesity (MHO) at 4.90 % and metabolically unhealthy obesity (MUO) at 3.47 %, followed by employees (MHO 6.63 %, MUO 4.45 %) and functionaries (MHO 6.74 %, MUO 4.94 %). Workers had the highest MHO prevalence rate at 8.51 %, while farmers had the highest MUO rate at 6.16 %. Obesity-associated complications were 1.5-3 times more common among obese individuals than those in the normal BMI category, with inequality observed across different occupational groups.
CONCLUSIONS: In China, a large number of adults with obesity have poor metabolic health, highlighting the importance of considering metabolic status when addressing obesity-related chronic diseases. Addressing the inequality in obesity rates can inform public health strategies to tackle the increasing problem of obesity and its associated complications in China.
Primary and metastatic tumor specimens are collected during lymphadenectomy and used for tissue microarray analysis, mutational analysis of T-synthase and Cosmc, immunohistochemical staining of Tn antigen and sialyl Tn antigen, and customized gene expression array analysis of 400 genes associated with glycobiology. Pre-lymphadenectomy blood is collected from patients at baseline for customized glycan array analysis of 300 carbohydrates.
The invention discloses an application of a wheat bran polyphenol extract in preparing a blood fat reducing medicine. Belongs to the technical field of medicine. The wheat bran polyphenol extract can reduce the food effect ratio of obese rats and inhibit the weight increase of the rats; reducing fat, Lee's index and obesity index of fat rat. Reduce liver weight and liver factor. Can obviously reduce the levels of TG, TC, HDL-C, LHL-C, ALP, ALT, AST and TBA in the serum of obese rats. Reduce ADPN and LEP level in liver homogenate, and increase LPL and HL level. Reduce the level of IL-6, IL-1 beta and TNF-alpha in liver homogenate of obese rats and increase the activity of GSH-PX. The pathological results show that the wheat bran polyphenol extract can reduce the degree of liver injury caused by hyperlipidemia to different degrees.
In a plastic composition for taking dental impressions as described in Specification 754,375, the zinc fluoride is replaced by lead fluoride.  U.S.A. Specification 2,657,971 also is referred to.ALSO:In a plastic composition for taking dental impressions as described in Specification 754,375 the zinc fluoride is replaced by lead fluoride. In an example 5.0 gm. of lead fluoride is added to a mixture of 72 gm. alkali metal alginate, 220 gm. diatomaceous earth, 7 gm. tetrasodium pyrophosphate, and 40 gm. calcium sulphate hemi-hydrate. U.S.A. Specification 2,657,971 also is referred to.
OBJECTIVE: To describe the prevalence of routine white noise exposure in children who undergo sound field audiometry.
METHODS: A retrospective cohort study was conducted at a pediatric otolaryngology clinic affiliated with an academic tertiary care hospital. The medical records of children who underwent sound field audiometry were reviewed and data was collected regarding demographics and audiogram results. The group was divided into two cohorts based on routine exposure to white noise. Children exposed to white noise were tested with warble tones, while those not exposed were tested with narrow-band noise.
RESULTS: 127 patients underwent sound field audiometry testing, of which 96 (75.6%) were reported by their parents to use white noise for sleep. The mean age at time of testing was 1.6 years (95% Confidence Interval [CI] 1.5-1.7). 104 (81.9%) children were able to respond to at least four of the sound field thresholds, and there was no significant difference between the children exposed to white noise and those who were not (P = 0.459). Mean pure tone average (PTA) was 26.2 dB (95% CI 25.2-27.2) and mean speech reception threshold (SRT) was 19.2 dB (95% CI 18.2-20.2). The sound field response rate, PTA, and SRT were similar between these two groups.
CONCLUSIONS: The routine use of white noise therapy was extremely common in this pediatric population. The use of warble tones as the audiometric stimuli for children exposed to white noise resulted in similar testing success compared to the use of narrow-band noise in children not exposed to white noise.
BACKGROUND: Enteroatmospheric fistula (EAF) is an abnormal communication between the gastrointestinal tract and the atmosphere. This phenomenon is still considered one of the most significant challenges faced by general surgeons after abdominal surgery. Primary goals of managing EAF include controlling and diverting intestinal contents outside the abdominal cavity, protecting surrounding tissues from retraction, and promoting wound healing. Achieving these goals is not easy. EAF has a 40% mortality rate. Several techniques have been proposed for managing this problem, including negative pressure wound therapy. The use of bladder catheters, nipples, endoscopic stents, vascular grafts, and fistula funnel, among other options, in the management of EAF has also been described.
CASE REPORT: The patient in the current report underwent Hartmann reversal surgery. On postoperative day (POD) 5, he had an anastomotic leak with ischemia of the descending colon and the transverse colon. Resection of the ischemic colon was performed, followed by creation of a terminal ileostomy on the last ileal loop on the right side. The first small orifice of EAF appeared on POD 23, the second on POD 28, and the third on POD 45. On POD 253, the patient underwent resection of the fistulated loop, extensive vitreolysis of the entire small intestine, and mechanical jejunojejunal laterolateral anastomosis to reestablish the canalization toward the previous terminal ileostomy on the right side. Complete closure of the skin was evident on POD 358.
CONCLUSION: There is no ideal treatment approach that is valid for all cases of EAF. Spontaneous closure of an EAF is unlikely but feasible in the setting of a single, deep lesion with limited output and when intestinal continuity is preserved.
Investigators plan to treat patients with paclitaxel weekly for a total of approximately 16 weeks (8 weeks before ultrasonography for response assessment and 8 weeks before surgery in good responders). Paclitaxel 80mg/m2 will be given on days 1, 8, 15 and so on for a total of 8 doses.
FIELD: medicine, neuroreanimation, neurosurgery, neurology. SUBSTANCE: method involves intravenous administration of alphoscerate choline in the dose 8-10 g/24 h and clophelin in the dose 0.4-0.6 mcg/kg/h is administrated simultaneously in the process of infusion into the same or other vein. Method provides elimination of vegetative instability and maintenance high and stable concentration of alphoscerate choline and it metabolites in blood plasma and in brain tissue. Invention can be used for treatment of post-ischemic disorders of brain. EFFECT: improved and enhanced treatment method. 1 tbl, 2 dwg, 1 ex
A method of coding drug pills in which a machine readable code is placed on the outer surface of the drug pills. The code includes the name and dosage of the pill. The code is a linear bar code, a radial bar code, a code on the outer peripheral edge of a tablet, or a coaxial code extending completely around a capsule. The code is applied to the pill by a) engraving the outer surface of the pill, b) by applying a code label, or c) by painting the code on the pill. In a method of distributing coded drug pills, the identification information is read from the pill. A desired drug delivery information file for a patient is also read. The identification information for the drug pill is compared to the desired drug delivery information prior to delivery of the pill to the patient. An alarm is generated upon detection of discrepancies between the pill identification information and the desired drug delivery information. A drug delivery system includes: a code reader for reading identification information from individually coded drugs and from patients; an input device for retrieving the desired drug delivery information; a comparator for comparing the identification information for an individually coded drug with the desired drug delivery information for the patient; and an alarm signal that is initiated upon detecting a discrepancy between the identification information for a drug to be delivered to a patient and the desired drug delivery information.
PROBLEM TO BE SOLVED: To obtain a cosmetic having ultraviolet light absorbing function in a wide wavelength, a free radical eliminating function and an additional function such as allergy suppressing function, containing a polyphenol derived from a rosaceous fruit. SOLUTION: This cosmetic contains a polyphenol derived from a rosaceous fruit (preferably an immature apple fruit). The polyphenol is preferably obtained by treating a squeezed fruit juice or an extracted solution of the rosaceous fruit with adsorbent, eluting the adsorbed fraction with a hydrous alcohol such as ethanol. For example, a method for washing a raw material, grinding/ compressing the raw material while adding sulfurous acid, then adding a pectinase to the ground/compressed material and obtaining a clear fruit juice by centrifugal separation, filtration, etc., may be cited as the method for squeezing the fruit juice. A styrene-divinylbenzene-based resin may be cited as the adsorbent. A 50% alcohol solution is preferable as hydrous alcohol used for the elution of the polyphenol.
SSc-ILD subjects will be defined by those who fulfill 2013 American College of Rheumatology SSc criteria and have forearm modified Rodnan skin scores (mRSS) ≥1 (a validated, semi-quantitative scoring system for dermal fibrosis) and clinically relevant SSc-interstitial lung disease (ILD). A subject will be defined as having ILD if they have radiographic evidence for ILD and a forced vital capacity \<70% on pulmonary function test (PFT).
The purpose of this study is to evaluate the effect of access to nutrition services on pregnancy outcomes in the obese urban population. Approximately one fourth of women in the United States are overweight and nearly one third are considered to be obese. Pregnancy places obese women at increased risk for several adverse events in the antepartum, intrapartum, and postpartum period. There are many studies that have shown that obesity in pregnancy has a negative impact on pregnancy. However, currently there are few studies in the United States that specifically look at ease of access to nutrition services in an obese urban population and the effect this has on pregnancy outcomes. This study will be a randomized controlled study that will compare two groups of pregnant women with a BMI of 30 or greater one of which has access to nutritional services along with routine prenatal care while the other gets only routine prenatal care. The investigators hypothesize that the obese parturient who has access to nutritional services will have decreased weight gain during pregnancy and ultimately have improved pregnancy outcomes. This will help to guide future care for the obese parturient in the urban population who may have limited access to services.
PURPOSE: The long-term need for biliary duct intervention following Roux-en-Y gastric bypass surgery (RYGB) is uncertain. We investigated the rate of laparoscopic assisted retrograde cholangiopancreatography (LAERCP) following RYGB. Also, the pre-LAERCP diagnostic workup together with the true rate of choledocholithiasis in patients with or without prior cholecystectomy was investigated.
MATERIALS AND METHODS: Retrospective cohort study of RYGB and LAERCP performed at the Hospital South West Jutland, University Hospital of Southern Denmark, from 1 January 2013 to 31 May 2022.
RESULTS: One percent of patients (n = 13) with a history of RYGB (n = 1363) underwent LAERCP at our facility during a median follow-up of 60.6 months. The stone extraction rate was 66.7% in patients with in situ gallbladder and 12.5% in patients with prior cholecystectomy. Cannulation of the common bile duct was achieved in 96.7% of cases. Postoperative complications were observed in 22.6% of the cases.
CONCLUSION: Approximately 1% of RYGB patients needed LAERCP during a median follow-up of 5 years. In patients with a history of cholecystectomy, the LAERCP rate of stone extraction was very low (12.5%).
The present invention discloses a medicine for treating intestinal diseases, which is a Chinese patent medicine prepared from the raw materials with the following proportion by weight: 7 to 1.3 portions of digua fig stem and leaf and 9 to 17.5 portions of lightyellow sophora root according to conventional preparation technologies. The medicine is prepared according to miao medical theories. The medicine adopts common Chinese herbal medicines in folk as the raw materials, so the cost is low. The medicine has the functions of clearing heat, drying damp and relieving diarrhea. The medicine has the characteristics of easy preparation, low cost and favorable curative effect. Thereby, the medicine can be used for abdominal pain, diarrhea, etc. caused by damp-heat in large intestines.
A total of 20 term newborn infants with a median gestational age of 40 weeks (range: 37-42 weeks) will be selected from the Gynecology and Obstetrics Hospital (Assiut University). All control infants should have an Apgar score of \> 9 at 1, 5, and 10 minutes.
Trauma-related guilt is common and impairing among trauma survivors, particularly among treatment seeking Veterans with posttraumatic stress disorder (PTSD). Although evidence-based trauma-focused PTSD treatments such as Cognitive Processing Therapy (CPT) are effective to treat PTSD and trauma-related guilt, many still experience symptoms or maintain their diagnosis after treatment, and dropout from these generally 12+ session protocols is high. Veterans show lower response and higher dropout than others with PTSD. Delivering protocols that are generally 12 or more sessions challenges the Veterans Affairs (VA) healthcare system given high demand for mental health care. For these reasons, additional and less burdensome approaches are needed. Brief treatment that targets mechanisms that are distressing and associated with multiple problems and disorders may be an understudied but promising way to treat PTSD and other posttraumatic psychopathology. The investigators' work shows that a brief treatment targeting trauma-related guilt and shame, Trauma Informed Guilt Reduction Therapy (TrIGR), can reduce guilt, PTSD, depression, and distress among Veterans and help them reengage with activities they find meaningful. Whether TrIGR is no less effective than longer, more resource heavy evidence-based PTSD treatments disseminated across by VA, like CPT, is the next critical question.

The proposed randomized clinical trial (RCT) will be the first non-inferiority trial of TrIGR and the first to compare TrIGR to a first tier PTSD treatment, specifically CPT. It will also be the first to evaluate TrIGR with Veterans from all eras with guilt from any type of traumas, as the investigators previous work was exclusively with Veterans of the conflicts in Iraq and Afghanistan with deployment-related traumas. 158 Veterans across two VA sites will be randomized to TrIGR or CPT. Exclusion criteria will be minimal so that generalizability will be high. Treatment will be delivered in VA mental health clinics. The primary aim is to evaluate if TrIGR is non-inferior to CPT in reducing PTSD symptom severity among Veterans with PTSD who endorse trauma-related guilt. Secondary aims are to evaluate TrIGR's non-inferiority relative to CPT regarding depression severity. The investigators will explore potential mechanisms of treatment, such as the relationship between change in guilt and shame change in PTSD symptoms. The study is critical to establish whether TrIGR is effective for a much larger group of Veterans and whether it is as effective as longer treatments already available in VA to inform if TrIGR warrants further study and dissemination in VA.
The installation of the orthodontic appliances promotes an increase in the retentive area available for microbial aggregation, difficult the oral health promotion and, in addition, promotes the artificial selection of biofilms containing a higher load of pathogenic microorganisms. In this way, it becomes of critical importance, the development of techniques that might aid in the reduction of the oral microbial load. One possible approach is the use of the Antimicrobial Photodynamic Therapy (APDT). In this direction, the objective of this study was to assess the clinical utility of the APDT and the association of the APDT with the SDS surfactant as oral decontamination agents in orthodontic patients. The selected patients (n=24) were randomly distributed within seven experimental groups: G1 - Negative control, G2 - Curcumin mouthwash, G3 - Curcumin mouthwash+SDS, G4 - light irradiation, G5 - APDT, G6 - APDT+SDS and G7 - Positive Control (Chlorhexidine mouthwash). Nonstimulated saliva samples were collected from each one of the patients in three steps (S), as follows: S1- Initial condition, S2 - Treatment with mouthwashes (water, Chlorhexidine or Curcumin) and S3 - After APDT treatment. The efficacy of the proposed treatment protocols was assessed in function of the survival fraction observed in each group. The obtained results were statistically analyzed using variance analysis (ANOVA) and the Kruskal-Wallis test.
FIELD: medicine. SUBSTANCE: proposed strain of human rhotavirus - a producer of high-active specific animal serum (for diagnosis) and lactoserum of cows (for prophylaxis of rhotaviral infection). Strain of human rhotavirus 568 is deposited in State Virus Collection of Virology Institute at number GKV 2288. Proposed strain is isolated from sick child with acute gastroenteritis. Strain shows high reproductive activity with development of ЦПД and complete cell destruction after 18-48 h and high immunogenic properties. Strain is stable at laboratory conditions at cultivation at the level of 15 passages. Strain used for immunization of animal (guinea pig, rabbit, cow) can be used for preparing of high-active specific sera. EFFECT: improved method of sera preparing.
Tissues are exposed to diverse inflammatory challenges that shape future inflammatory responses. While cellular metabolism regulates immune function, how metabolism programs and stabilizes immune states within tissues and tunes susceptibility to inflammation is poorly understood. Here, we describe an innate immune metabolic switch that programs long-term intestinal tolerance. Intestinal interleukin-18 (IL-18) stimulation elicited tolerogenic macrophages by preventing their proinflammatory glycolytic polarization via metabolic reprogramming to fatty acid oxidation (FAO). FAO reprogramming was triggered by IL-18 activation of SLC12A3 (NCC), leading to sodium influx, release of mitochondrial DNA, and activation of stimulator of interferon genes (STING). FAO was maintained in macrophages by a bistable switch that encoded memory of IL-18 stimulation and by intercellular positive feedback that sustained the production of macrophage-derived 2'3'-cyclic GMP-AMP (cGAMP) and epithelial-derived IL-18. Thus, a tissue-reinforced metabolic switch encodes durable immune tolerance in the gut and may enable reconstructing compromised immune tolerance in chronic inflammation.
Individuals in the Deposit COntract group will be required to put down a 200$ deposit but will earn it back, as well as a bonus, contingently for meeting alcohol reduction requirements. For this study, this is counted as having a Transdermal Alcohol COntent below equal to .02 g/dl. They will be monitored using the Transdermal Alcohol Monitoring device.
The invention belongs to the field of traditional Chinese medicines, and particularly relates to traditional Chinese medicine decoction for treating the coronary heart disease and a preparation method thereof. The traditional Chinese medicine decoction is prepared from, by weight, 25-35 parts of Radix Salviae Miltiorrhizae, 25-35 parts of rhizome corydalis, 10-20 parts of roots of pilose asiabell, 10-20 parts of Ginkgo biloba Linn. fruit, 10-20 parts of Lilium brownii var. viridulum Baker, 10-20 parts of radix curcumae, 5-10 parts of root peel of Lycium chinense Mill., 10-20 parts of Hedyotis diffusa, 10-20 parts of radix astragali, 5-10 parts of eucommia bark, 5-10 parts of poria cocos, 10-20 parts of Puncturevine Caltrop fruit, 3-5 parts of rhizoma polygoni cuspidate, 10-20 parts of cassia twigs, 5-10 parts of Schisandrachinensls (Turcz.) Baill, 5-10 parts of cortex moutan and 3-5 parts of fructus piperis longi. The traditional Chinese medicine decoction has the functions of promoting blood circulation to remove blood stasis, promoting coronary circulation to relieve pain and tonifying qi and yin. The medicinal materials can be used in cooperation for effectively improving the coronary blood flow and enhancing the cardiac muscle oxygen content, the requirement of cardiac muscles for blood is increased, the functions of dredging coronary arterial blood vessel walls, promoting coronary artery repair and the like are achieved, and the traditional Chinese medicine decoction has the advantages of being remarkable in treatment effect, safe, reliable, free of toxic and side effects, rapid in effect and the like when used for treating the coronary heart disease.