anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Clostridioides difficile sequence type (ST) 35 has been found in humans and animals worldwide. However, its genomic epidemiology and clonal transmission have not been explored in detail. In this study, 176 C. difficile ST35 isolates from six countries were sequenced. Genomic diversity, clonal transmission and epidemiological data were analyzed. Sporulation and virulence capacities were measured. Four ribotypes (RT) were identified including RT046 (97.2%), RT656 (1.1%), RT427 (0.6%), and RT AI-78 (1.1%). Phylogenetic analysis of 176 ST35 genomes, along with 50 publicly available genomes, revealed two distinctive lineages without time-, region-, or source-dependent distribution. However, the distribution of antimicrobial resistance genes differed significantly between the two lineages. Nosocomial and communal transmission occurred in humans with the isolates differed by ≤ two core-genome single-nucleotide polymorphism (cgSNPs) and clonal circulation was found in pigs with the isolates differed by ≤ four cgSNPs. Notably, interspecies clonal transmission was identified among three patients with community acquired C. difficile infection and pigs with epidemiological links, differed by ≤ nine cgSNPs. Toxin B (TcdB) concentrations were significantly higher in human isolates compared to pig isolates, and ST35 isolates exhibited stronger sporulation capacities than other STs. Our study provided new genomic insights and epidemiological evidence of C. difficile ST35 intraspecies and interspecies clonal transmission, which can also be facilitated by its strong sporulation capacity.
Lung adenocarcinoma (LUAD) is the most widespread cancer in the world, and its development is associated with complex biological mechanisms that are poorly understood. Here, we revealed a marked upregulation in the mRNA level of C1orf131 in LUAD samples compared to non-tumor tissue samples in The Cancer Genome Atlas (TCGA). Depletion of C1orf131 suppressed cell proliferation and growth, whereas it stimulated apoptosis in LUAD cells. Mechanistic investigations revealed that C1orf131 knockdown induced cell cycle dysregulation via the AKT and p53/p21 signalling pathways. Additionally, C1orf131 knockdown blocked cell migration through the modulation of epithelial-mesenchymal transition (EMT) in lung adenocarcinoma. Notably, we identified the C1orf131 protein nucleolar localization sequence, which included amino acid residues 137-142 (KKRKLT) and 240-245 (KKKRKG). Collectively, C1orf131 has potential as a novel therapeutic marker for patients in the future, as it plays a vital role in the progression of lung adenocarcinoma.
The adverse reactions in overdose cases are similar to the adverse reactions encountered in normal clinical experience (see ADVERSE REACTIONS). Oral doses of up to 640 mg/day have been given to adult patients with pathological hypersecretory conditions with no serious adverse effects. In the event of overdosage, treatment should be symptomatic and supportive. Unabsorbed material should be removed from the gastrointestinal tract, the patient should be monitored, and supportive therapy should be employed.   
  
The oral LD50 of famotidine in male and female rats and mice was greater than 3000 mg/kg and the minimum lethal acute oral dose in dogs exceeded 2000 mg/kg. Famotidine did not produce overt effects at high oral doses in mice, rats, cats and dogs, but induced significant anorexia and growth depression in rabbits starting with 200 mg/kg/day orally. The intravenous LD50 of famotidine for mice and rats ranged from 254 to 563 mg/kg and the minimum lethal single I.V. dose in dogs was approximately 300 mg/kg. Signs of acute intoxication in I.V. treated dogs were emesis, restlessness, pallor of mucous membranes or redness of mouth and ears, hypotension, tachycardia and collapse.
<P>PROBLEM TO BE SOLVED: To provide a hair-growth pack preparation and a hair restoration preparation with high efficacy rate and realizing powerful hair-growth and hair restoration beyond common sense, and a safe and cheap hair-growth and or hair restoration stimulating supplement.  <P>SOLUTION: The hair-growth pack preparation, hair-growth and hair restoration preparation contain a mucous membrane protecting/repairing agent, a large amount of protein, isoquercitrin and hydrotalcite. The preparation is a supplement increasing number and volume of hair made solely from natural foods and excellent in safety that can be used for a long term. The preparation raises hair even places without hair pore (does not raise other than scalp). A number of hairs can be raised at one time (10,000/once in average). The preparation is a new type hair-growth/growth restoration clearly observable with naked eyes in an hour by any body.  <P>COPYRIGHT: (C)2008,JPO&INPIT
Participants will receive \>=10 mg/week methotrexate orally along with 2 times 1 gram (g) rituximab IV infusions on Days 1 and 15. Participants will also receive placebo infusions on Days 3 and 17 in place of cyclophosphamide.
Between July 2009 and December 2020, medical records of all women with lower urinary tract symptoms but without cystocele who visited the urogynecological department of a medical center for urodynamic evaluation were reviewed. Those women who have no complete data of a 3-day bladder diary were excluded from this study. Bladder oversensitivity was diagnosed if the volume of strong desire was less than 300mL. We compared the urodynamic parameters to bladder diary parameters in order to find the best correlation between these 2 measurements for the diagnosis of bladder oversensitivity.

STATA software was used for statistical analysis. Chi2 test, univariate and multivariable logistic regression tests were used for statistical analysis as appropriate. A p \< 0.05 was considered as statistically significant.
Gluten free diet during 18 months. The subjects will be referred to a nutritionist every 6 months. Vitamin D 800 U Daily, Omega 3 fatty acids and probiotics as nutritional supplements.
The invention provides a novel strain of Bacillus radiatus (Radioactive sp.), and the Bacillus radiatus (Radioactive sp.) 80 with the collection number of GDMCC 61438 is provided. The bacillus radiatus (Radiobacillus sp.) 80 provided by the invention can be directly used as a gene donor of UV radiation resistant transgenic organisms, and an excellent resistance gene of the bacillus radiatus can be transferred into other organisms, so that the bacillus radiatus can obtain an excellent stress resistance character. And meanwhile, the method can also be used for developing high UV radiation protection articles. Has important significance for researching the UV resistance mechanism of the DNA and promoting the development of new DNA technology in environmental protection, biological repair, human health and the like.
The invention relates to a method for extracting wormwood flavone from isopropanolamine organic acid ionic liquid, and belongs to the technical field of biochemical engineering. Firstly, adding isopropanolamine into a certain amount of water, uniformly mixing, and then slowly adding organic acid into the solution under a certain condition to fully dissolve the organic acid, thereby obtaining the ionic liquid extractant. Soaking the treated folium Artemisiae Argyi into the obtained ionic liquid at a certain ratio, and performing ultrasonic-assisted extraction and solid-liquid separation to obtain extractive solution. And performing secondary extraction, column chromatography, recrystallization and the like on the extracting solution to obtain the wormwood flavone. The method is simple to operate and easy for industrial production. The ionic liquid is safe and nontoxic, and can be directly used as raw materials of medicines, daily chemicals and the like or regenerated by resin after being recycled. Solves the problems of pollution discharge and toxic residue in the traditional wormwood extraction method.
The invention discloses a traditional Chinese medicine product for moxibustion therapy and a preparing method, preparing device and application thereof. The product comprises a moxa stick and a gasket. The moxa stick comprises litsea cubeba, folia perillae acutae and folium artemisiae argyi. The gasket comprises raw rhubarb, borneol and cinnamon. By adding the gasket through which heat generated from burning of the moxa stick is transmitted, scalding of the skin of patients can be avoided; meanwhile, by transmitting heat through the gasket, heat transmission is more uniform and milder, and moxibustion therapy effect is improved; besides, the efficacy of traditional Chinese medicine components in the gasket can be fully realized by means of heat generated from burning of the moxa stick, and the effect of moxibustion therapy is improved greatly. The traditional Chinese medicine product can be used for treating rheumatism, insomnia and qi-blood deficiency, and can achieve cold dispelling and exterior syndrome relieving.
BACKGROUND: In Sweden, surgical treatment of Hirschsprung's disease (HSCR) was centralized from four to two pediatric surgery centers 1st of July 2018. In adults, centralization of surgical care for complex or rare diseases seems to improve quality of care. There is little evidence supporting centralization of pediatric surgical care. The aim of this study was to assess surgical management and postoperative outcome in HSCR patients following centralization of care.
METHODS: This study retrospectively analyzed data of patients with HSCR that had undergone pull-through at a pediatric surgery center in Sweden from 1st of July 2013 to 30th of June 2023. Patients managed from 1st of July 2013 to 30th of June 2018 (before centralization) were compared with patients managed from 1st of July 2018 to 30th of June 2023 (after centralization) regarding surgical treatment, unplanned procedures under general anesthesia or readmissions up to 90 days after pull-through as well as complications classified according to Clavien-Madadi up to 30 days after pull-through.
RESULTS: In the 5-year period prior to centralization, 114 individuals from 4 treating centers were included and compared to 83 patients from 2 treating centers in the second period. There was no difference regarding age at pull-through or proportion of patients with a stoma prior to pull-through. An increase of laparoscopically assisted endorectal pull-through (8.8% to 39.8%) was observed (p < 0.001). No significant differences were seen in postoperative hospital stay, unplanned procedures under general anesthesia, or readmissions up to 90 days after pull-through. There was no difference in severe complications (Clavien-Madadi ≥ 3); however, HAEC treated with antibiotics increased following centralization (10.5-24.1%; p = 0.018).
CONCLUSION: Centralization of care for HSCR does not seem to delay time to pull-through nor reduce severe complications, unplanned procedures under general anesthesia or readmissions up to 90 days after pull-through. The increased HAEC rate may be due to increased awareness of mild HAEC.
LEVEL OF EVIDENCE: Level III.
Although inroads in the study of acupuncture for acute pain conditions have been made, there are still critical gaps in the literature in both basic/mechanistic and clinical areas. Very little is know about what impact conservative, easily transportable and administered treatments, such as acupuncture, might have in preserving military battlefield readiness. The proposed research proposal is an incremental step with the ultimate goal to increase the knowledge base and expand clinical applications of acupuncture for acute pain conditions that are relevant to military personnel and operations.The purpose of this proposal is to conduct a scientifically rigorous investigation of auricular acupuncture for the treatment of acute pain in the emergency room setting at a military hospital using a two phase clinical trial design. This pragmatic investigation will provide a unique opportunity to develop clinically relevant questions that can be further evaluated in the context of basic science and more robust clinical trial designs. The specific aims of this study are to 1) Determine the feasibility of conducting a clinical trial of auricular acupuncture in the treatment of military personnel with acute pain who present to the emergency room at Andrews Air Force Base, using a pilot two phase clinical trial approach and 2) Gather data on the effect size of auricular acupuncture in treating acute pain conditions. Persons presenting to the emergency room at Malcolm Grow with acute pain syndromes that do not require medical attention beyond pain management strategies will be invited to participate in the study and asked for informed consent. The study will involve a preliminary pilot test period during which 20 persons are entered into a consecutive case series study to test the feasibility of collecting data and implementing the treatment procedures in the busy emergency room setting. Treatment will involve auricular acupuncture using SEDATELEC Aiguille Semi-Permanent (ASP) needles bilaterally at two acupuncture points - Cingulate Gyrus and Thalamic Nuclei. Baseline demographic and pain indicator information will be collected prior to treatment. Follow-up data on pain levels and medication use will occur prior to leaving the ER and 24 hours following treatment. The primary endpoint is change in pain levels at 24 hours, as measured by the verbal Numerical Rating Scale (NRS). 24 hour follow-up will occur via the telephone. Following successful completion of the preliminary study, a two arm, randomized clinical pilot trial of 100 participants (N = 50 per arm) will be conducted using the same protocol as the case series study. Patients will be randomized to either usual emergency medical care or acupuncture + medical co-management. Follow-up data will be collected on the schedule outlined above by assessors blinded to treatment assignment.
Multiple myeloma (MM) is a hematologic malignancy notorious for its high relapse rate and development of drug resistance, in which cell adhesion-mediated drug resistance plays a critical role. This study integrated four RNA sequencing datasets (CoMMpass, GSE136337, GSE9782, and GSE2658) and focused on analyzing 1706 adhesion-related genes. Rigorous univariate Cox regression analysis identified 18 key prognosis-related genes, including KIF14, TROAP, FLNA, MSN, LGALS1, PECAM1, and ALCAM, which demonstrated the strongest associations with poor overall survival (OS) in MM patients. To comprehensively evaluate the impact of cell adhesion on MM prognosis, an adhesion-related risk score (ARRS) model was constructed using Lasso Cox regression analysis. The ARRS model emerged as an independent prognostic factor for predicting OS. Furthermore, our findings revealed that a heightened cell adhesion effect correlated with tumor resistance to DNA-damaging drugs, protein kinase inhibitors, and drugs targeting the PI3K/Akt/mTOR signaling pathway. Nevertheless, we identified promising drug candidates, such as tirofiban, pirenzepine, erlotinib, and bosutinib, which exhibit potential in reversing this resistance. In vitro, experiments employing NCIH929, RPMI8226, and AMO1 cell lines confirmed that MM cell lines with high ARRS exhibited poor sensitivity to the aforementioned candidate drugs. By employing siRNA-mediated knockdown of the key ARRS model gene KIF14, we observed suppressed proliferation of NCIH929 cells, along with decreased adhesion to BMSCs and fibronectin. This study presents compelling evidence establishing cell adhesion as a significant prognostic factor in MM. Additionally, potential molecular mechanisms underlying adhesion-related resistance are proposed, along with viable strategies to overcome such resistance. These findings provide a solid scientific foundation for facilitating clinically stratified treatment of MM.
The compound (DEAEITHHH) is used in the pharmaceutical industry. The method is performed when equivalent quantities of 2-diethylaminoethylchloridehydrochloride and thiocarbamide are heated in a medium of aliphatic alcohol for 4 h at 65-84 degrees C. The reaction mass produced is cooled, the crystals are separated by filtration and are dried. The filtrate produced is subjected to secondary concentration by evaporation in order to produce secondary crystals. The total yield of 2-diethylaminoethylisothiouronic cholidehydrochloride is over 93%. Its melting temperature is from 190 to 194 degrees C, and the product purity comes to over 95%. 1 claim
PURPOSE:To shorten the reading time of a digitized image by utilizing that the ratio of images to be inspected to be compared with the past examination images is small in the examination images of a subject. CONSTITUTION:Images recorded in a roll film for group medical examination are digitized and the several volumes of up-to-date examination images out of the digitized images are stored in a magnetic disk device (MD) 2 or a large capacity rapid memory (hereinafter simply called a memory). Simultaneously, the several volumes of the past examination images are similarly stored in a light disk device (LD) 3. Then, up-to-date examination images are read out from the MD 2 or the memory, displayed on image display devices 4a, 4b, and while reading out the images, images selected as the ones to be inspected are successively specified. The past examination images corresponding to the specified images to be inspected are read out from the LD 3 by another task and stored in the MD 2 or the memory. After ending the reading of all the up-to-date examination images, the past examination images corresponding to the specified images to be inspected are read out from the MD 2 or the memory and displayed on the display devices 4a, 4b so as to be compared and read out.
PURPOSE:To obtain a bathing agent giving smooth feeling to the skin in bathing and moist skin after the bath. CONSTITUTION:The characteristic of this bathing agent composition is the compounding of betaine. The compounding ratio of (oily component):(betaine) is 10:1 to 1:10, i.e., 0.1-10 pts.wt. of betaine is compounded based on 1 pt.wt. of oily component. Glycine betaine is used as the betaine and the oily component is selected from oil and fat, wax, hydrocarbon, higher fatty acid, higher alcohol, ester, essential oil, silicone, etc.
PURPOSE:To quickly and easily select a vascular smooth muscle proliferation inhibiting agent and a vascular smooth muscle contraction inhibiting agent avoiding the sacrifice of many animals by screening the proliferation inhibiting agent using a cultured vascular smooth muscle cell strain SM-3 having high proliferation rate. CONSTITUTION:A cultured vascular smooth muscle cell strain SM-3 cell is cultured in a medium containing 10% bovine fetus serum, transferred after 3 days at the latter half of the logarithmic proliferation period and subcultured to prepare a proliferation- type SM-3 cell having high proliferation rate. The cell is transferred to a medium and cultured for 2 days. An agent to be tested (e.g. staurosporin) is added to the medium, the cell form is observed with the lapse of time and the vascular smooth muscle proliferation inhibiting activity of the agent is screened by comparing the cell form with the cell free from the testing agent. As an alternative method, the agent to be tested is added to a medium planted with the proliferation-type SM-3 cell, a contraction-inducing agent such as prostaglandin F2alpha is added under a microscope and the cell contraction state is observed to screen the vascular smooth muscle contraction inhibiting activity of the testing agent.
The invention relates to a traditional Chinese medicine composition for treating alopecia and poliosis as well as a preparation method and application thereof. The traditional Chinese medicine composition comprises a preparation A and a preparation B, wherein the preparation A is prepared from the following raw materials: radix polygoni multiflori, mulberry fruit, glossy privet fruit, herba ecliptae, radix rehmanniae, angelica sinensis, cortex eucommiae, fructus psoraleae, radix astragali, rhizoma chuanxiong, rhizoma corydalis, rhizoma smilacis glabrae, rhizoma gastrodiae, herba agrimoniae and oncised notopterygium rhizome. The preparation B is prepared from the following raw materials: mulberry fruit, radix sophorae flavescentis, cortex moutan radicis, fructus crataegi, halloysitum rubrum, rhizoma alismatis and liquorice. The raw materials of the preparation A are crushed into coarse powder, then ethyl alcohol is added into the coarse powder for coldly soaking and put in sealed storage for more than two months so as to obtain a medicine liquid, and alums is added into the medicine liquid for filtering and obtaining a filtrate. The filtrate is daubed on the overall scalp for twice a day. The preparation B is decocted and taken hotly for one dose a day in two times. The traditional Chinese medicine composition disclosed by the invention has the functions of relieving exterior syndrome and clearing heat, calming liver wind, activating blood circulation and nourishing blood, activating proliferation and the like, is obvious in effect of treating alopecia and poliosis and conducive to the relief of symptoms such as anxiety, psychentonia and the like caused by alopecia and poliosis. The traditional Chinese medicine preparations of the traditional Chinese medicine composition have no toxic and side effect and are easy to take.
Consent will be obtained from at least 20 randomly selected patients with each of the following self-identified diagnoses in the VCRC Patient Contact Registry: Behçet's disease, EGPA, GCA, GPA, MPA, PAN and TAK that have already completed the VCRC Diagnostic Questionnaires. Permission will be obtained to contact subjects' primary vasculitis care providers to request that the providers complete an online version of this questionnaire (or print copy, if they prefer), and request specific chart items from their office to further verify the data.
Patients who do not wish to be randomized or who meet the randomization-specific exclusion criteria will be offered enrolment into the non-randomized, prospective observational arm of the study. The participant and their surgeon will collaboratively decide which of the 2 treatments the participant will receive.