anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
PURPOSE: Up to 90% of people with Parkinson's disease (PD) develop communication difficulties over the course of the disease. While the negative effect of dysarthria on communicative participation has been well-documented, the impact of the occurrence of acquired stuttered disfluencies on communication in different speech situations is unknown. This study aimed to determine if the frequency of occurrence of stuttered disfluencies affects communicative participation in individuals with PD, and whether such a relationship is mediated by examiner- and self-rated measures of disease severity.
METHOD: Conversational speech samples were collected from 100 people with PD aged 53-91 years to calculate the frequency of occurrence of stuttered disfluencies. Participants completed the Communicative Participation Item Bank to assess participation in communicative situations. Information on overall speech, cognitive, and motor performance was collected using both self-rated and examiner-rated methods.
RESULTS: Participants with PD presented with 0.2%-9.9% stuttered disfluencies during conversation. Overall, participants with PD reported their communicative participation to be impacted "a little" (19.5 ± 7.0), but there was considerable interindividual variation. A higher frequency of stuttered disfluencies was associated with significantly lower communicative participation (ρ = -0.32, p < .01). In addition, examiner-rated frequency of stuttered disfluencies (p < .01), speech (p < .01), and motor severity (p = .04) were all significant predictors of communicative participation. Using self-ratings, speech (p < .01) and cognitive (p < .01) measures significantly predicted communicative participation.
CONCLUSIONS: In people with PD, communicative participation was significantly worse for those with a higher frequency of stuttered disfluencies. Examiner- and self-rated measures of disease severity contributed different information related to communicative constraints. Together, these results highlight the importance of individualized and holistic speech therapy that considers a wide variety of symptoms, including stuttered disfluencies, to ensure positive functional outcomes.
SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.26850169.
The invention relates to the field of biology, in particular to a recombinant protein and a gel preparation containing the same. In some embodiments, the amino acid sequence of the recombinant protein is SEQ ID NO. 7 or SEQ ID NO. 8. The recombinant protein with the sequence of SEQ ID NO. 7 is recombinant I-type humanized collagen (Fu Huo factor). The recombinant protein can greatly improve the content of the I-type procollagen. The gel dressing containing the recombinant protein can be used for treating pelvic floor dysfunction of model animals, and has remarkable effect.
This is a randomized, sham-controlled, parallel group study. The study will last up to 5 weeks. After informed consent, subjects with idiopathic hypersomnia with an MSLT mean sleep latency of \>8 minutes will undergo actigraphy and those with an average sleep time of \>10 hours per day will continue with the study while those with \<10 hours sleep time will be excluded. In addition, OSA subjects with complaints of hypersomnia with an ESS score \<10 will also be excluded. Female subjects of child bearing age and not menopausal will have a pregnancy test performed as pregnancy is an exclusionary criteria.

Subjects will be randomized to receive either active tDCS or sham stimulation for 30 minutes daily for 4 sessions. The randomization will be generated by means of a computer-generated random-number table. An unrestricted randomization scheme will be followed. Subjects will be blinded as to whether they are receiving sham or active tDCS treatments. The investigator who will conduct the analysis of all outcomes will be blinded as to subject treatment assignment.

All stimulation visits will be completed within a five-consecutive day period; that is one stimulation visit may be missed provided a total of four stimulation visits are completed within a five-day period. Outcome measures will include: psychomotor vigilance test (PVT), subjective measures of sleepiness, and the Center for Epidemiologic Studies Depression (CES-D) scale. PVT will be performed pre- and post- stimulation during the first and last stimulation sessions. Subjective measures of sleepiness include the following: Epworth Sleepiness Scale (ESS), Stanford Sleepiness Scale (SSS), Functional Outcomes of Sleep Questionnaire-10 (FOSQ-10), and Visual Analogue Scale (VAS).
Many different strategies have been used to minimize the hemodynamic responses to skull pin placement with varying results. Local anesthetic infiltration at pin application sites has been used but was always unsuccessful in obtunding the hemodynamic responses to skull pin placement. Dexmedetomidine, an alpha-2 adrenoceptor agonist, has been recently introduced as a sedative for patients on mechanical ventilation. In addition to its sedative effect; Dexmedetomidine has significant analgesic qualities and has been labeled as "analgesia-sparing". To the best of the investigator's knowledge, few studies investigated Dex use to suppress hemodynamic responses to skull pinning. The aim of the current study was to evaluate the lowest effective dose of Dexmedetomidine in attenuating the hemodynamic responses to skull pin placement for craniotomies. Lidocaine, administered subcutaneously at the head-holder pin sites, was more effective in preventing the blood pressure response to skull-pin than was deepening the level of anesthesia.
Chemotherapy is the current standard treatment for unresectable recurrent cervical carcinoma after radiotherapy or distant metastasis of cervical carcinoma. The most effective regimens are cisplatin-based chemotherapy. After failure of the cisplatin-based chemotherapy, there is still no treatment that has been proved to be effective.

Human papilloma viruses (HPV) have been consistently implicated in causing cervical cancer especially those high-risk types (HPV 16,18,31,45) have been strongly associated with cervical cancer. HPV 16 was found in more than 50% of cervical cancer tissues. Results from many animal tumor models have indicated that immunization with tumor antigen-pulsed dendritic cells can trigger a long-lasting anti-tumor immune response and significantly inhibit the growth of implanted tumor cells. Recently, many clinical trials have been conducted to evaluate the feasibility and safety of immunizing cancer patients with tumor antigen-pulsed dendritic cells. No severe toxicity has been reported and some patients were shown to respond to the treatment. Based on previous animal and clinical studies by other investigators, we propose to evaluate the potential of immunizing cancer patients with antigen-pulsed autologous dendritic cells as a cancer vaccine to treat for recurrent cervical cancers after failure of cisplatin-based chemotherapy treatment or refusing chemotherapy. In this study, we will generate dendritic cells by culturing patient's autologous PBMC with GM-CSF and IL-4 in vitro. These dendritic cells will be pulsed with synthetic peptides representing the CTL epitopes on HPV Type 16 E7. Antigen-pulsed dendritic cells will be injected into inguinal lymph nodes under the guidance of real-time sonography. Each patient will receive four injections and 12 patients in total will be recruited for this study.
Aphasia is a language disorder caused by brain injury that often results in difficulties with speech production and comprehension, significantly impacting the affected individuals' lives. Recently, artificial intelligence (AI) has been advancing in medical research. Utilizing machine learning and related technologies, AI develops sophisticated algorithms and predictive models, and can employ tools such as speech recognition and natural language processing to autonomously identify and analyze language deficits in individuals with aphasia. These advancements provide new insights and methods for assessing and treating aphasia. This article explores current AI-supported assessment and treatment approaches for aphasia and highlights key application areas. It aims to uncover how AI can enhance the process of assessment, tailor therapeutic interventions, and track the progress and outcomes of rehabilitation efforts. The article also addresses the current limitations of AI's application in aphasia and discusses prospects for future research.
Participants receive MK-8777 100 mg BID for 27 days followed by one day of 100 mg QD. Participants receive MK-8777 for a total of 28 days.
Evidence shows that moderate and regular physical activity is associated with the prevention of non-communicable diseases, increased bone density, reduced risk of dementia, and prevention of falls among older adults. Despite the numerous benefits of physical activity, many older adults do not meet the recommended physical activity guidelines of 150 min/week of moderate-to-vigorous intensity physical activity in Canada. MI is a client-centered counselling style for strengthening a person's own motivation and commitment to change. MI helps evoke the person's own motivation for changes through reflective listening, engaging, evoking, and planning. MI has shown to be promising in the general adult population for improving physical activity levels, however, there were mixed results for the effectiveness of MI among older adults. In addition, based on the available evidence, there are no studies evaluating the potential long-term effects of MI on physical activity levels among older adults. This feasibility study is necessary to explore possible challenges that may be encountered in the future larger trial with a two-month follow-up. Due to the recent pandemic (COVID-19), the intervention will be conducted virtually through the videoconferencing platform (Zoom). Therefore, the purpose of this study is to determine the feasibility of VIrtual Motivational INTerviewing (VIMINT) to promote physical activity levels among older adults; post-intervention and at two-month follow-up.

The participants will receive five sessions of the virtual MI over a five-week period through the Zoom platform and each session will last between 45 to 60 minutes. The intervention will be delivered by trained personnel in MI. The MI strategies will include evoking change and guiding participants in establishing goals for improving physical activity. After the 2-month evaluation, counsellors and participants will be invited for a one-on-one Zoom interview. The aim is to explore the perception of the counsellors and participants about the VIMINT study including, views about virtual MI, benefits, and challenges.
* Do not mix or dilute KORSUVA prior to administration.
  * Inspect KORSUVA for particulate matter and discoloration prior to administration. The solution should be clear and colorless. Do not use KORSUVA vials if particulate matter or discoloration is observed.
  * KORSUVA is supplied in a single-dose vial. Discard any unused product.
  * Injection volume to be administered is determined by patient’s target dry body weight in kilograms (one patient may use less than the full contents of the vial or use more than one vial). See Table 1
In addition to alendronate sodium tablets, your doctor may suggest one or more of the following lifestyle changes:

  * Stop smoking. Smoking may increase your chance of getting osteoporosis.
  * Reduce the use of alcohol. Too much alcohol may increase the risk of osteoporosis and injuries that can cause fractures.
  * Exercise regularly. Like muscles, bones need exercise to stay strong and healthy. Exercise must be safe to prevent injuries, including fractures. Talk with your doctor before you begin any exercise program.
  * Eat a balanced diet. Having enough calcium in your diet is important. Your doctor can advise you whether you need to change your diet or take any dietary supplements, such as calcium or vitamin D.



Rx only
Chlorambucil can cause fetal harm when administered to a pregnant woman. Unilateral renal agenesis has been observed in 2 offspring whose mothers received chlorambucil during the first trimester. Urogenital malformations, including absence of a kidney, were found in fetuses of rats given chlorambucil. There are no adequate and well-controlled studies in pregnant women. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant.
PURPOSE:To provide a blood substitute having excellent oxygen-transporting capability, by reacting hemoglobin with a polyalkylene glycol in the absence of oxygen or in an atmosphere having low oxygen concentration, and using the resultant adduct as an oxygen carrier. CONSTITUTION:In a blood substitute containing a hemoglobin-polyalkylene glycol adduct as an oxygen carrier, said adduct is prepared by the reaction of hemoglobin with a polyalkylene glycol (e.g. polyethylene glycol) in the absence of oxygen or in an atmosphere having low oxygen concentration. The bonding is carried out through an amide bond formed by the dehydrative condensation of the amino group of hemoglobin and the carboxyl group of polyalkylene glycol imparted with carboxyl group. An oxygen transporting substance having high oxygen supplying capability can be prepared by substituting the air in the reactor with an inert gas such as nitrogen, argon, etc. to reduce the partial pressure of oxygen to 0-30mm.Hg.
The immediate and long term success of coronary surgery is dependent on the construction of a high quality anastomosis with a durable conduit to an appropriate target coronary vessel. Significant advances in medical therapy including early post-operative aspirin administration and increased use of arterial grafting have improved early, midterm and late graft patency. However, modern coronary bypass series continue to report perioperative graft occlusions rates as high as 11%. These very early graft failures have been predominantly ascribed to technical problems at graft anastomosis sites and may be preventable. New intraoperative graft assessment technologies have recently become available which can identify technical problems such that they can be repaired in the operating room. However, these techniques increase the length of the bypass operation and may have false positives, which may lead to unnecessary and potentially damaging graft revisions. The primary objective of the proposed study is to determine if a strategy of intraoperative patency assessment and graft revision can decrease the rate of graft occlusion or significant stenosis(\>50%) at 6-12 weeks after coronary artery bypass grafting (CABG) versus traditional operative management without routine intraoperative patency assessment.
Therapeutic Lovenox dosing split into three times a day dosing for 5 day. Xa levels a measured.
The present invention relates to an anhydrous solid perfume primer cosmetic composition and a method for manufacturing the same and, more particularly, to an anhydrous solid perfume primer cosmetic composition containing 0.1-10 wt% of an incense capturing agent and 0.2-20 wt% of a thickening agent based on total weight of the composition. The average particle size of the incense capturing agent is 100-1000 um. The incense capturing agent is formed of one or more among silica, alumina, and zeolite. The thickening agent is formed of a mixture of inorganic ingredients and clay ingredients. The mixture contains 0.1-10 wt% of the inorganic ingredient based on total weight of the composition. The inorganic ingredient is formed of one or more selected among silica, alumina, and zeolite. The mixture contains 0.1-10 wt% of the clay ingredients based on total weight of the composition. The clay ingredient is formed of one or more among bentonite, montmorillonite, saponite, hectorite, biedellite, and stevensite. In the described present invention, the long-lasting property of incense is improved and oil turns into gel, thus spots on skin can be covered. Also, the shape is hardly changed by evaporation of the incense and a change of temperature and the hardness of wax of which predetermined amount is used is softened for maintaining the formulation. Thus, anhydrous solid perfume primer cosmetic composition is easy to fill and has soft texture.
Periodontitis and diabetes affect the course and outcome of each other. Many studies have shown that for patients with periodontitis, concomitant diabetes can aggravate the destruction of periodontal tissue and accelerate the progression of periodontitis, which is an important risk factor for periodontitis. Affected by diabetes, patients with poor glycemic control have worse periodontal status, and the prognosis of periodontitis treatment is more suspicious. Conversely, periodontitis also affects diabetic status, and periodontitis is associated with dysglycemia, increased insulin resistance, and increased risk of diabetic complications. After periodontal therapy, it is expected to reduce the level of systemic inflammation and ultimately improve glycemic control and overall prognosis of diabetes. However, the treatment of periodontitis with diabetes is still a challenge, and how to improve the prognosis of patients with periodontitis with type 2 diabetes remains to be studied.

BioGaia Prodentis is a probiotic chewable tablet containing Lactobacillus reuteri (combination of L. reuteri DSM 17938 and L. reuteri ATCC 5289). Studies have shown that the use of the probiotics has an additional effect on periodontal therapy. However, in the periodontitis patients with type 2 diabetes, whether the use of this probiotic can improve the effect of periodontal therapy, few relevant research have published.
Attention-matched control website with five modules to address an introduction to mindsets, growth mindsets of intelligence, growth mindsets of self-control, growth mindsets of people, and an integrative summary. Program takes approximately 30-45 minutes to complete.
Heart failure with preserved ejection fraction (HFpEF) comprises approximately one-half of all diagnoses of heart failure. There is significant overlap of this clinical syndrome with chronic kidney disease (CKD), with many shared comorbid conditions. The presence of CKD in patients with HFpEF is one of the most powerful risk factors for adverse clinical outcomes, including death and heart failure hospitalization. The pathophysiology linking HFpEF and CKD remains unclear, but it is postulated to consist of numerous bidirectional pathways, including endothelial dysfunction, inflammation, obesity, insulin resistance, and impaired sodium handling. The diagnosis of HFpEF requires certain criteria to be satisfied, including signs and symptoms consistent with volume overload caused by structural or functional cardiac abnormalities and evidence of increased cardiac filling pressures. There are numerous overlapping metabolic clinical syndromes in patients with HFpEF and CKD that can serve as targets for intervention. With an increasing number of therapies available for HFpEF and CKD as well as for obesity and diabetes, improved recognition and diagnosis are paramount for appropriate management and improved clinical outcomes in patients with both HFpEF and CKD.
Rotavirus is the most common cause of diarrhea in children worldwide. In 2016, rotavirus infection resulted in 258 173 300 episodes of diarrhea and 128 500 child deaths in the globe. The study aimed to assess the magnitude of Rotavirus vaccine dose-two dropout and associated factors among children who received rotavirus vaccine dose-one in sub-Saharan African countries. The appended and most recent demographic and health survey (DHS) dataset of 17 sub-Saharan African countries was used for data analysis. A total of 73,396 weighted samples were used. Factors associated with the outcome variable were considered significant if their p-values were ≤ .05 in the multilevel mixed-effect logistic regression model. The overall Rotavirus vaccine dose-two dropouts was 10.77% (95% CI 10.55%, 11.00%), which ranged from 2.77% in Rwanda to 37.67% in Uganda. Being younger, late birth order, having difficulty accessing health facilities, having no media exposure, having no work, having home delivery, having no antenatal follow-up, and having no postnatal checkup were factors significantly associated with the outcome variable. The overall Rotavirus vaccine dose-two dropout was higher in sub-Saharan African countries which implies that vaccine dropout is still a great issue in the region. Special attention should be given to those mothers who are young, who have no work, who give birth at home, who experienced difficulty in accessing health facilities, and late birth orders. Furthermore, targeted interventions should be considered for improving access and utilization of media, antenatal care, and postnatal care services.
FIELD: medicine. SUBSTANCE: invention relates to conservative treatment of polyarthritis using medicinal agents of natural origin. Invention proposes the group of claims combined with the united inventive project. Invention proposes two agents for normalization of homeostasis in treatment of polyarthritis using principle of steam phytotherapy. The proposed method of treatment using these agents provides the effective action on mechanism of development of arthrous diseases and align biochemical and serological blood indices and enhance the disease remission. EFFECT: enhanced effectiveness of agent and treatment. 6 cl, 2 tbl, 2 ex
The extract obtained from the expressed leaves of Rheum (see Group VI) is irradiated to form vitamin D.  Specification 552,704 is referred to.ALSO:Vitamin C and fat-soluble vitamins, pro-vitamins and other non-saponifiable constituents are recovered from the leaves of Rheum by pressing them.  The expressed juice contains the vitamin C and is recovered by precipitaing organic acids and then adding lead acetate at pH 7 to precipitate vitamin C.  The leaf residue is extracted (see Group III) and carotene, tocoferol, sterols, vitamins K and F, can be recovered.  Vitamin D may also be obtained by irradiation of the extract from the leaf residue. Specification 552,704 is referred to.ALSO:Leaves of Rheum are pressed to remove a substantial part of the juice which contains vitamin C, and the solid residue is extracted with a fat-dissolving agent, the agent being removed from the solution obtained, by evaporation to give fat-soluble vitamins, provitamins and other non-saponifiable constituents.  In an example, the expressed juice is atomised and dried and vitamin C recovered therefrom by precipitation with lead acetate at pH7 after organic acids have been removed.  The residue of leaves is dried and extracted with benzene and the latter subsequently evaporated.  This extraction residue may be used as such, or further treated as by dissolving in ethyl alcohol, saponifying with alcoholic sodium hydroxide in an oxygen free atmosphere, adding water-free calcium chloride in ethyl alcohol to precipitate the soaps, and removing the precipitate by centrifuge or filtration.  To remove excess calcium chloride, solid carbon dioxide is added.  The precipitate is washed and pet-ether added to dissolve the non-saponifiable constituents. Fat dissolving agents specified include ether, motor spirit or other hydrocarbons or mixtures thereof, whilst soap precipitating agents are halides of the alkaline earth metals or aluminium sulphate.  Specification 552,704 is referred to.  The Specification as open to inspection under Sect. 91 comprises also this treatment of other green vegetables generally. This subject-matter does not appear in the Specification as accepted.