anthonyyazdaniml/gliner-biomed-curated-corpus huggingface dataset:
Superantibodies having enhanced autophilic, catalytic, and/or membrane- penetrating properties are prepared by affinity-based conjugation of a photoactivatable organic molecule to a target immunoglobulin. The photoactivatable organic molecule bears a chromophoric aromatic hydrocarbon moiety, which has affinity for the immunoglobulin. Upon photolysis, the organic molecule is covalently linked to the immunoglobulin. A preferred organic molecule is a peptide and a preferred aromatic hydrocarbon moiety is a tryptophan residue. The photoactivatable organic molecule need not bear a purine, pyrimidine or azido group to effect binding to the immunoglobulin and/or photoactivation. The superantibodies can enhance the potency and expand the targeting range of target antibodies. Autophilic superantibodies can promote apoptosis of target cells and/or enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Exemplary of such diseases are atherosclerosis and cardiovascular disease. Membrane-penetrating superantibodies can prevent apoptosis by binding to intracellular anti-caspase signal proteins. Compositions containing the superantibodies, as well as methods of making and using them, are disclosed.
INTRODUCTION: The challenge of treating Glioblastoma (GBM) tumors is due to various mechanisms that make the tumor resistant to radiation therapy. One of these mechanisms is hypoxia, and therefore, determining the level of hypoxia can improve treatment planning and initial evaluation of its effectiveness in GBM. This study aimed to design an intelligent system to classify glioblastoma patients based on hypoxia levels obtained from magnetic resonance images with the help of an artificial neural network (ANN).
MATERIAL AND METHOD: MR images and PET measurements were available for this study. MR images were downloaded from the Cancer Imaging Archive (TCIA) database to classify glioblastoma patients based on hypoxia. The images in this database were prepared from 27 patients with glioblastoma on T1W + Gd, T2W-FLAIR, and T2W. Our designed algorithm includes various parts of pre-processing, tumor segmentation, feature extraction from images, and matching these features with quantitative parameters related to hypoxia in PET images. The system's performance is evaluated by categorizing glioblastoma patients based on hypoxia.
RESULTS: The results of classification with the artificial neural network (ANN) algorithm were as follows: the highest sensitivity, specificity, and accuracy were obtained at 86.71, 85.99 and 83.17%, respectively. The best specificity was related to the T2W-EDEMA image with the tumor to blood ratio (TBR) as a hypoxia parameter. T1W-NECROSIS image with the TBR parameter also showed the highest sensitivity and accuracy.
CONCLUSION: The results of the present study can be used in clinical procedures before treating glioblastoma patients. Among these treatment approaches, we can mention the radiotherapy treatment design and the prescription of effective drugs for the treatment of hypoxic tumors.
BACKGROUND: Voice outcome after carbon dioxide transoral laser microsurgery (CO2TOLMS) for glottic cancer is of prime importance. However, a comprehensive overview according to the European Laryngological Society (ELS) classification of cordectomies is still lacking. The aim of this systematic review is to summarize data on voice outcome associated with individual types of ELS glottic cordectomy after CO2TOLMS.
MATERIALS AND METHODS: A systematic review of the literature was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. The initial search identified 936 records of which 25 publications were then included. Voice outcome data (Voice Handicap Index [VHI] version 30, grade of dysphonia [G] and maximum phonation time [MPT]) were extracted per resection type. Weighted averages were calculated.
RESULTS: Data show a gradual increase in the VHI scores although they were still similar for all cordectomy types (range 14.2 to 21.5). The grade of dysphonia showed a gradual increase with increasing resection depth (range 1.0 to 1.9). There was a gradual decrease in the MPT (range 15.2 to 7.2).
CONCLUSION: Voice outcome is related to cordectomy type with mild dysphonia characterizing ELS type I, II and III cordectomies, while more extended cordectomies (ELS type IV, V and VI) result in moderate dysphonia and shortness of breath during phonation. The voice handicap experienced by patients is limited even in the more extended cordectomies.
Polycystic ovary syndrome (PCOS) is a complex reproductive endocrinological disorder influenced by a combination of genetic and environmental factors. Linoleic acid (LA) is a widely consumed ω-6 polyunsaturated fatty acid, accounting for approximately 80% of daily fatty acid intake. Building upon the prior investigations of our team, which established a connection between LA levels in the follicular fluid and PCOS, this study deeply examined the specific impact of LA using a granulosa cell line. Our findings revealed that LA exerts its influence on granulosa cells (GCs) by binding to the estrogen receptor (ER). Activated ER triggers the transcription of the FOXO1 gene. Reactive oxygen species (ROS)-related oxidative stress (OS) and inflammation occur downstream of LA-induced FOXO1 activation. Increased OS and inflammation ultimately culminate in GC apoptosis. In summary, LA modulates the apoptosis and inflammation phenotypes of GCs through the ER-FOXO1-ROS-NF-κB pathway. Our study provides additional experimental evidence to comprehend the pathophysiology of PCOS and provides novel insights into the dietary management of individuals with PCOS.
Supine hypertension is a common problem that affects at least 50% of patients with primary autonomic failure. Supine hypertension can be severe and complicates the treatment of orthostatic hypotension. Drugs used for the treatment of orthostatic hypotension (eg, fludrocortisone and pressor agents), worsen supine hypertension. High blood pressure may also cause target organ damage in this group of patients. The pathophysiologic mechanisms causing supine hypertension in patients with autonomic failure have not been defined.

This study will test the hypothesis that continuous positive airway pressure (CPAP) has an acute lowering-BP effect in autonomic failure patients with supine hypertension. CPAP is a widely-used treatment for sleep-related breathing disorders including sleep apnea, that uses mild air pressure to keep the breathing airways open. It involves using a CPAP machine that blows air into a tube connected to a mask placed over the nose, or nose and mouth. For these studies, a commercial CPAP device will be used to apply pressure sequentially at 0, 4, 8, 12 and 16 cm H2O for 1-20 minute each. Depending on the BP response and tolerability to CPAP, CPAP may be applied during the night using a CPAP level that was tolerable and showed a BP-lowering effect during the acute test.
After a complete mobilization of the colon, a resection 2-3cm distal to the ileocecal junction and at the upper part of the rectal ampulla are conducted; the cecum is then lowered into the pelvis, without any rotation, and an antiperistaltic cecorectal anastomosis is performed between the cecal fundus (after appendectomy) and the rectum, after introduction of a stapler through the cecal resection line. Use a Pfannestiel incision to perform the anastomosis and to remove the resected colon. The cecal-rectal anastomosis is performed by introducing the stapler via the anus, with the intention of carrying out a ''cleaner,'' ''tensionless'' procedure.
The invention discloses a kind of method that saponin(e is extracted from the Radix Astragali, its operating procedure is as follows：1. crush, the Radix Astragali is shredded, grind to form powdery；2. refluxing extraction, round-bottomed flask is added by the powder raw material after crushing, adds ethanol, loads onto reflux, is extracted；3. concentrate, the filtrate that will be extracted carries out suction filtration, with vacuum pump pressure it is whole go out ethanol until brownish red syrupy shape；4. crystallize, add acetate dissolution, suction filtration to remove insoluble matter, add hydrochloric acid to solution muddiness, to there is yellow needles saponin(e to separate out, suction filtration obtains crystal crude product.5. recrystallize, crystal crude product adds hot water dissolving to continue suction filtration, plus hydrochloric acid adjusts pH, suction filtration to be dried in baking oven and weigh this.Extracting method of the invention has the advantages that extraction time is short, method is simple, recovery rate is high, recovery is easy, is adapted to industrialized production.
Pulmonary arterial hypertension (PAH) is a mean pulmonary artery pressure of 25 mmHg or more at rest. Since the diagnosis of PAH can be made mostly in the late phase of the disease, severe functional and hemodynamic problems are prevalent in patients. In addition, patients commonly present with dyspnea, fatigue, weakness, general exercise intolerance, chest pain, syncope, and abdominal distension. These signs and symptoms are due to reduced oxygen consumption and decreased cardiac output. Activity dyspnea is evident in patients in the early stages of the disease. There is limited number of studies in pediatric PAH patients investigating exercise intolerance. While the cardiopulmonary exercise test can be safely performed in pediatric PAH patients, the six-minute walk test is both an independent predictor of prognosis and reflects the severity of the disease in these patients. However, there are no studies in the literature investigating and comparing exercise capacity, respiratory muscle strength, respiratory functions, dyspnea, and physical activity levels in pediatric PAH patients compared to age- and sex-matched healthy children. For this reason, in this study, the level of physical impairments of children with pediatric PAH was investigated for the first time compared to healthy children. In addition, there has been no study in the literature investigated the relationship between dyspnea, which can be seen significantly from the early stages of the disease in pediatric PAH patients, with exercise capacity, respiratory function, respiratory muscle strength, physical activity levels and blood count parameters.

It is a cross-sectional study. At least 15 PAH patients and 15 age-and sex-matched healthy controls were aimed to include in the study. Individuals' exercise capacity using six minute walk test, respiratory muscle strength using a mouth pressure device, pulmonary function using spirometry, dyspnea using Modified Borg scale, physical activity using multi-sensory activity monitor were evaluated. The assessments were completed in two days.
Participants will report daily symptom as above. The SCH system will notify the study NP for any of the following symptoms measured by the NTSS6: aching, allodynia, burning, lancinating, numbness, and prickling that are concerning. Participants will receive a NP call back either the same day or the next day, depending on the time they reported their symptoms. The NP will follow a standardized script to elicit details about the CIPN symptoms and recommend and prescribe CIPN treatment per the treatment algorithm.
In-person+internet; Individuals in this condition receive a behavioral weight loss intervention over the internet weekly for 24 weeks and monthly for the following 12 months. Every month during the first 24 weeks and every third month during the following year they have an in-person meeting.
This is a multicentre, stratified, randomized, sham-controlled clinical trial. 180 eligible participants will be randomly allocated into verum acupuncture group or sham acupuncture group, in a 1:1 ratio. The verum acupuncture group will receive 16 sessions of manual acupuncture treatments over an eight-week period, while the sham acupuncture group will receive sham acupuncture treatments with non-penetrating needling. Health education will be provided to participants in the two groups. The primary outcomes will be the changes in the mean levels of serum uric acid 8 weeks after randomization. The secondary outcomes will be the changes in the mean levels of serum uric acid 4, 12, 16, and 20 weeks after randomization. Other secondary outcomes included effective rates, the proportion of patients with acute gouty arthritis, changes in body weight and BMI, safety evaluation and deqi evaluation. The central randomization and data collection will be conducted by an electronic data management system.
In addition to standard prenatal care the COPE-P intervention group will also receive 1.5 hours each week for 6 weeks the cognitive-behavior skills building program driven by CBT as the theoretical framework by health care providers trained in COPE-P by Dr. Melnyk. The content of the COPE program is driven by the literature review, the theoretical framework, previous studies of COPE interventions with mothers of preterm infants and prior work with pregnant minority women by our team.
PURPOSE OF COMMENTARY: This commentary aims to offer a perspective on the effect of tirzepatide on hypoxic burden and provide indirect evidence of cardiovascular risk reduction after tirzepatide for the treatment of obstructive sleep apnea and obesity. It also discusses the role of tirzepatide-induced weight loss in the management of obstructive sleep apnea.
RECENT FINDINGS: In the SURMOUNT-OSA phase 3 trials, tirzepatide, a new GIP/GLP-1 receptor co-agonist, reduced the apnea-hypopnea index, hypoxic burden, and body weight in adults with moderate-to-severe obstructive sleep apnea and obesity. The change in apnea-hypopnea index is clinically relevant, but its impact on cardiovascular mortality remains unclear. Conversely, hypoxic burden predicts cardiovascular mortality across populations independent of AHI. We attempted to postulate the magnitude of cardiovascular benefits of tirzepatide based on the reduction in hypoxic burden. Tirzepatide treatment for obstructive sleep apnea and obesity seems to result in hypoxic burden values associated with a lower cardiovascular mortality rate and thus might attenuate the negative cardiovascular impact of hypoxic burden.
The purpose of this study is to assess if chemotherapy using docetaxel and cytoxan (TC) or hormonal therapy using exemestane can shrink the size of your breast tumor and allow you to preserve your breast or have less extensive surgery on your breast. Additionally, by receiving chemotherapy or hormonal therapy before surgery, we will be able to determine if the treatment you receive is effective in treating your cancer. Prior to entering this study, a special test, called the Oncotype DX assay, will be performed on a small amount of your cancer from the biopsy you had at the time you were diagnosed with breast cancer, to determine the likelihood that your cancer will benefit from and shrink with chemotherapy and hormonal therapy. You will only be eligible to enter this study if the recurrence score of your cancer determined using the Oncotype DX assay is less than or equal to 24. Patients with hormone receptor-positive breast cancers with recurrence scores less than or equal to 24 have been previously demonstrated to obtain a larger benefit from hormonal therapy, compared to chemotherapy, when these agents are given after surgery. The ability of hormonal agents and chemotherapy to shrink cancers prior to surgery has not been specifically examined in hormone receptor-positive cancers with recurrence scores less than or equal to 24.
The invention discloses a method and a device for determining pneumothorax, wherein the method comprises the steps of obtaining medical images, wherein the medical images comprise multi-frame cross-section images. Pneumothorax in each frame of cross-sectional image is segmented to obtain a first region. And screening a second region from the first region based on the position and the area of the first region in each frame of cross-sectional image. A saccade in the multi-frame cross-sectional image is determined. And removing the capsule in the second region to obtain a third region. And when the third areas exist in the cross-sectional images with the continuous preset frames and the sum of the areas of the third areas is larger than or equal to a second threshold value, determining that the third areas in the cross-sectional images with the preset frames are pneumothorax. The method and the device improve the speed and accuracy of determining the pneumothorax in the chest image.
The invention provides a traditional Chinese medicine formula used for treating urticaria. The formula comprises components of, by weight: 7 to 11 parts of Chinese wolfberry root-bark, 7 to 11 parts of slenderstyle acanthopanax root-bark, 12 to 18 parts of white mulberry root-bark, 4 to 8 parts of dried ginger, 6 to 12 parts of areca peel, 12 to 18 parts of dictamni cortex, 6 to 12 parts of cortex moutan, 12 to 18 parts of red tuckahoe peel, 12 to 18 parts of Chinese waxgourd peel, 12 to 18 parts of white hyacinth bean, and 6 to 12 parts of shrubalthea bark. Compared to existing technologies, the urticaria-treating traditional Chinese medicine formula provided by the invention is aimed at inner pathogenic factors of urticaria. With the formula, urticaria is treated based on syndrome differentiations. The formula has advantages of fast effect, low cost, and no toxic or side-effect. With the formula, both symptoms and root causes are treated.
BACKGROUND: Recurrent respiratory tract infections (rRTIs) are a common reason for immunodiagnostic testing in children, which relies on serum antibody level measurements. However, because RTIs predominantly affect the respiratory mucosa, serum antibodies may inaccurately reflect local immune defences. We investigated antibody responses in saliva and their interplay with the respiratory microbiota in relation to RTI severity and burden in young children with rRTIs.
METHODS: We conducted a prospective cohort study including 100 children aged <10 years with rRTIs, their family members and healthy healthcare professionals. Total and polyreactive antibody concentrations were determined in serum and saliva (ELISA); respiratory microbiota composition (16S rRNA sequencing) and respiratory viruses (quantitative PCR) were characterised in nasopharyngeal swabs. Proteomic analysis (Olink) was performed on saliva and serum samples. RTI symptoms were monitored with a daily mobile phone application and assessed using latent class analysis and negative binomial mixed models.
RESULTS: Serum antibody levels were not associated with RTI severity. Strikingly, 28% of salivary antibodies and only 2% of serum antibodies displayed polyreactivity (p<0.001). Salivary polyreactive IgA was negatively associated with recurrent lower RTIs (adjusted OR 0.80, 95% CI 0.67-0.94) and detection of multiple respiratory viruses (adjusted OR 0.76, 95% CI 0.61-0.96). Haemophilus influenzae abundance was positively associated with RTI symptom burden (regression coefficient 0.05, 95% CI 0.02-0.08).
CONCLUSION: These results highlight the importance of mucosal immunity in RTI severity and burden, and suggest that the level of salivary polyreactive IgA and H. influenzae abundance may serve as indicators of infection severity and burden in young children with rRTIs.
Patients in the experimental group will receive OrthoPAT drains, which will be used to collect and retransfuse postoperative blood loss. Drains will be removed after 48 hours.
The present invention discloses a feed for treating small water turtle saprolegniasis and a preparation method thereof, and belongs to the technical field of terrapin feed processing. The feed includes the following raw materials: pomaceacanaliculata powder, locust powder, pumpkin powder, corn flour, salt, dimethyl-beta-propiothetin, betaine, phenylalanine, adenine nucleotides, sodium diacetate, sodium guanylate and Chinese medicine preparations. The feed is prepared by drying, grinding, sieving, mixing, granulating, drying, sterilization and other steps. The present invention combines the effectiveness of a variety of traditional Chinese medicine, and has effects of resisting to bacteria, diminishing inflammation, clearing away heat and toxic materials, improving immune function and the like. The small water turtles have good absorption efficiency of the feed, the small water turtle mortality rate caused by the saprolegniasis can be effectively reduced, and farming risks are reduced. The feed has reasonable formulation and rich nutrition, can increase intake of the small water turtles with saprolegniasis, can improve growth rate, and can shorten growth period. The preparation method has simple operation and low production costs, and is conducive to application promotion.
CES 100µA for one hour daily, five to seven days per week. Rating scales will be administered at baseline (i.e., pre-treatment), twice a week and at the end of the study.
The invention discloses a traditional Chinese medicine composition with an anti-tumor effect. The composition is prepared from the following raw materials: dragon's blood, stigma croci, arisaema cum bile, prunella vulgaris, radix scrophulariae, sweet broomwort herbs and amorphophallus dunnii. The raw materials are prepared into dosage forms in pharmacy, comprising granules, capsules or tablets. To verify the pharmacology effect of the composition, the capsules, namely the anti-tumor capsules, are researched through pharmacological experiments, and the researched result proves that the anti-tumor capsules have an obvious anti-tumor effect in the body, and have no adverse effects on obviously changing the weight of mice. For the composition, anti-tumor in-vitro experiments are also carried out, and the experiment result indicates that the anti-tumor capsules have a certain inhibiting effect on culture in vitro cells of human hepatoma cell lines 7404 and ascitic tumor cell lines S180 of the mice. Compared with cyclophosphamide, the cyclophosphamide is a traditional anti-cancer drug but has the side effects of causing mutagenesis, teratogenesis and the like, but the anti-tumor capsules have better in-vitro anti-tumor effect and higher safety.
The present invention relates to a psychotherapeutic device capable of measuring a brainwave signal, to provide mental stability and psychological treatment. According to the present invention, the psychotherapeutic device comprises: a body; a band wearing the body on a face; and a shock absorption member coupled to the inner surface of the body. The body comprises: an operation button controlling operation of the device; a voice output means outputting a voice signal; and an LED bar disposed on a position corresponding to user′s eyes. The LED bar has a first LED row disposed at a position corresponding to the user′s left eye and a second LED row disposed at a position corresponding to the user′s right eye. A protection film is disposed on the side surface of the LED bar corresponding to the user′s eyes and includes a diffused reflection prevention film and a window film. Moreover, the psychotherapeutic device comprises: a brainwave measurement sensing means including a pair of brainwave measurement electrodes installed on both eye portions inside the body having the LED bar installed therein to measure a brainwave, which is a kind of a biometric signal, and one earth electrode; and a USB interface connecting a person computer or a smartphone. Accordingly, the psychotherapeutic device is connected to the person computer or the smartphone to be operated in accordance with a measurement request signal of a user′s brainwave by using the person computer or the smartphone so as to transfer the sensed brainwave signal to the person computer or the smartphone.