anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
The present invention relates to antigen-binding fragments that are specific for stressprotein-peptide complexes specifically associated with tumors, particularly human tumors, and compositions thereof. The compositions are suitable for diagnostic and pharmaceutical use. The invention further provides methods of making and screening for the antigen-binding fragments. The invention further encompasses compositions containing cancer-associated stress protein-peptide complexes (including derivatives thereof) and methods of use thereof. The cancer-specific stress protein-peptide complexes (&#39;SPPC&#39;s) are particularly useful in eliciting cancer-specific immunogenic responses against a plurality of cancers. The invention also provides novel phage display libraries for use in producing further SPPCs and anti-SPPCs of the invention.
Skin treatment compositions and methods provide a superficial depth skin peel and exfoliation utilizing a combination of four acids, a carrier gel, colorant(s), and a topical oxygen delivery system. The combination of acids, oxygen delivery, gel formulation and colorant(s) aid in the efficacy of the formulations to result in beneficial skin treatment compositions by creating an effective superficial peel without the use of BHA&#39;s and only using AHA&#39;s having a molecular weight greater than 100. The AHA&#39;s used in the present invention are intended to predominately impact the stratum corneum, the outermost layer of skin. The AHA&#39;s utilized in the present invention reduce corneocyte adhesion by impacting the ionic bonds in a manner that reduces the cohesion forces. The corneocytes are then more easily shed and replaced by the newer, bright layers underneath. This can give the skin a smoother and less scaly appearance.
To improve prediction accuracy of a machine learning model.SOLUTION: A medical information processing apparatus includes an adding section, a collection section, a first learning section, an acquisition section, and a second learning section. The adding section adds a correct answer label used for training a decision making model, which is used for decision making in medical care, in accordance with an operator&#39;s input instruction. The collection section collects status data which is data indicating an operator&#39;s status while doing work of adding the correct answer label. The first learning section trains a reliability determination model to which the status data is input and which outputs reliability of the correct answer label on the basis of the status data and the correct answer label. The acquisition section acquires input data on the decision making model. The second learning section trains the decision making model to which the input data is input and which outputs output data representing a result of decision making on the basis of the input data, the correct answer label, and the reliability.SELECTED DRAWING: Figure 2
A computer-implemented method for linking individuals&#39; datasets in a database may include receiving a target individual dataset of a target individual and a plurality of additional individual datasets. A computing server may generate a plurality of sub-cluster pairs of first parental groups and second parental groups. At least one of sub-cluster pairs includes a first parental group of matched segments and a second parental group of matched segments. A computing server may link the first parental groups and the second parental groups across the plurality of sub-cluster pairs to generate at least one super-cluster of a parental side. A computing server may assign metadata to one or more additional individual datasets of the plurality of additional individual datasets. The metadata may specify that the one or more additional individual datasets are connected to the target individual dataset by the parental side of the super-cluster.
Compositions for treatment of the skin are prepared by mixing with an oily or unguentous carrier an organic peroxidic or ozonidic compound. Acidic peroxides such as benzoyl, salicyl peroxides and the peroxides of butyric, lactic, caprylic, lauric, palmitic, stearic, phenylacetic, chaulmoorgric and &#34;hydrocarpic&#34; acids are suitable and also the derivatives of corresponding anhydrides, salts or esters. Peroxides of alcohols, esters, ketones, ethers and aldehydes may also be used. Mild oxygen splitting catalysts may be added.  Vehicles containing lanolin, spermaceti, beeswax, soaps, vegetable, animal and mineral oils, higher fatty acids, zinc oxide, boric acid, borax, gum tragacanth, gum acacia, and essential oils are suitable.  The compositions may be used as ointments, nasal sprays and toothpastes.
PURPOSE:To monitor the sleeping conditions of a number of persons all together in a centralizing fashion by constituting a sleep monitoring device of a plurality of beds each provided with bedding in which a filtering circuit, an amplifying circuit, a rectifying circuit, an integrating circuit, a comparing circuit, a timer, a judging circuit, and a piezoelectric element are disposed, and a display means for displaying the output signal of each judging circuit via a communicating means. CONSTITUTION:When a piezoelectric element 2 on each bed 1 is deformed by the motion of a user&#39;s body on a mattress 3, a voltage is generated from the piezoelectric element 2 by piezoelectric effects. Only frequency components of approximately 1 to 10Hz are allowed to pass through a filtering circuit 4, amplified by an amplifying circuit 5, rectified by a rectifying circuit 6, and integrated by an integrating circuit 7. When an output signal from a comparing circuit 8 is at Hi level a timer 9 starts measuring time and continues to do so. When the time measured by the timer 9 exceeds a predetermined level, a judging circuit 10 judges that the human body on each bed has fallen asleep. Data judged at each bed is integrally displayed in a display 13 via a communicating cable 12.
The invention belongs to the technical field of traditional Chinese medicines (TCMs) and provides a medicine used for treating eczema, aiming to solve the problem of treating eczema. The medicine is prepared from radix rehmanniae, Sichuan lovage rhizome, Chinese angelica, radix paeoniae alba, stiff silkworm, divaricate saposhnikovia root, cortex dictamni, cicada slough, amur corktree bark, oriental waterplantain rhizome, plantain seed, raw seeds of Job&#39;s tears, poria cocos, talc, tetrapanax papyriferus and atractylodes macrocephala according to a certain proportion. A preparation method of the medicine is characterized by comprising the following steps: after mixing the medicines, adding 600ml of water to a first dose to decoct the first dose until 200ml and adding 500ml of water to a second dose to decoct the second dose until 200ml. The medicine is taken on an empty stomach respectively in the morning and in the evening each day. In the TCM preparation, radix rehmanniae, Sichuan lovage rhizome, Chinese angelica, radix paeoniae alba, stiff silkworm and divaricate saposhnikovia root have the function of nourishing the blood to expel wind; cortex dictamni, cicada slough and amur corktree bark have the function of eliminating dampness to relieve itching; oriental waterplantain rhizome, plantain seed, raw seeds of Job&#39;s tears, poria cocos, talc, tetrapanax papyriferus and atractylodes macrocephala have the function of excreting dampness to transform turbidity. Through compatibility and synergy of the medicines, the medicine has good curative effects on eczema.
The utility model relates to a traditional chinese medicine package for orthopedics especially relates to a traditional chinese medicine package is used to treatment ankle injury, including package main part and inside chinese-medicinal material, the package main part is made up for square cotton and forms, the frenulum is made up respectively to the both sides of package main part, the package main part falls into the spacer, is used for the splendid attire chinese-medicinal material respectively, package main part one side is the feed inlet, the centre of package main part is the scissors mouth of certain interior angle, the two corners of the other end of the package main part that the scissors mouth is relative are retrieved and are the edge joint shape. The number of the spacer bushes is four to six. The internal angle of the scissors-shaped opening is 60 degrees. And the feed inlet is provided with a thread gluing or a zipper. The length of the packaging main body is 33cm, the width of the packaging main body is 26cm, the width of the bottom edge of the packaging main body is 20cm, and the width of the spacer sleeve is 4 cm. The utility model has the advantages that: the use is nimble changeable, and the package main part can both hug closely the ankle position, and furthest&#39;s performance traditional chinese medicine package detumescence is stopped pain and is acted on, reduces extravagantly.
PROBLEM TO BE SOLVED: To obtain a transparent oily gel composition for cleansing the skin, whose rinsing property is improved, by adding a fat phase and a specific ester to a system containing a polyol. SOLUTION: This composition is obtained by combining (A) a fat phase, (B) at least one ester of a fatty acid and a 5-7C carbohydrate, and (C) at least one polyol. In addition, (D) water may be contained in this composition. The component A is preferably an oil having a refractive index n&lt;0&gt; not higher than 1.45. The 5-7C carbohydrate of the component B is preferably glucose or an alkylglucoside derivative such as 1-methylglucoside. The component B is preferably an ester that is obtained by reacting a carbohydrate and an 8-30C saturated or unsaturated fatty acid. The component C is preferably ethylene glycol, glycerol, maltose, or the like. The proportion of each component to be formulated is: (A) 1-95wt.%, (B) 2-20wt.%, (C) 0.5-60wt.%, and (D) 0.01-30wt.%.
&lt;P&gt;PROBLEM TO BE SOLVED: To share information in real time by using an electronic pen and portable terminal equipment (e.g. cellphone, PDA) or the like, to shorten a time until collection, and to reduce mistake due to self-judgement in performing collection.  &lt;P&gt;SOLUTION: The server device 111 creates a draft based on first input data input from the outside through a network at first, and prints it on a business form for an electronic pen to create an entry business form. At the same time, a Web page based on the first input data is created. A user receives entry data entered on the entry business form by using an electronic pen. Each time the entry data and second input data input from the outside after the entry business form are acquired, it is added to the Web page.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
Abstract There are described ruthenium complexes to which an immunologically active material can be or is coupled. The ruthenium complex has the general formula                   I   wherein L1, L2 and L3 are the same or different and each signify a bi- or polycyclic ligand with at least two nitrogen-containing heterocycles, whereby at least one of these ligands is substituted with at least one group conferring water-solubility, and whereby at least one of these ligands is substituted, optionally via a spacer group, with at least one reactive group, and whereby the ligands L1, L2 and L3 are attached to the ruthenium via nitrogen atoms.     The ligands L1, L2 and L3 contain e.g. a 2,2&#39;-bipyridine, 1,10-phenanthroline, benzbathophenan-throline or bathophenanthroline group.     The spacer group is e.g. an alkylen group with a maximum of 8 C-atoms which is optionally substituted with -SO2-NH-, -S-, -O-, -COO- or -CO-NH-.     The active group, to which the immunologically active material is coupled is e.g. a -COOH, -I, -NH2, -NCS or -SO2Hal group.     As immunologically active material which can be coupled to the above mentioned ruthenium complexes come into consideration especially antigens, haptens or antibodies. e.g. antibodies to carcinoembryonic antigen.     The ruthenium complexes according to the present invention can be detected with great sensitivity by fluorescence spectroscopy.
PURPOSE: To obtain a hypotensive agent containing a peptide having a specific amino acid sequence or its salt as an active component, having high safety, exhibiting effective hypotensive action by the oral administration of a slight amount of the agent and utilizable as pharmaceuticals, functional foods, etc. CONSTITUTION: This agent contains a peptide having the amino acid sequence of the formula Lys Val Leu Pro Val Pro Gin and its salt as an active component. The objective agent can be produced from a component of animal milk such as cow&#39;s milk or goat milk by fermentation or proteinase treatment. The fermentation is preferably carried out by using Lactobacillus helveticus, etc., as a lactobacillus at 30-45 deg.C for 6-12hr until the fermented lactic acid concentration reaches 0.7-1.5wt.%. The proteinase treatment is carried out by mixing a lactobacillus-producing proteinase to an animal milk dissolved in a buffer solution and reacting at 30-50 deg.C for 1-12hr. The daily administration dose of the agent is preferably 1mg/kg-weight in terms of the active component.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a hemostatic material which is excellent in a hemostatic effect, in vivo decomposing and absorbing property, uniformity in quality, and stability, and which reduces the risk of mixing an animal-derived pathogen.  &lt;P&gt;SOLUTION: This hemostatic material contains thrombin and a synthetic polypeptide which can form a tri-helix structure. The molecular weight of the polypeptide can indicate a peak in the range of 5×10&lt;SP&gt;4&lt;/SP&gt;-100×10&lt;SP&gt;4&lt;/SP&gt;. The polypeptide may contain a peptide unit expressed at least by the formula, Pro-X-Gly (X indicates Pro or Hyp (hydroxyproline) in the formula). Thrombin can be a recombinant. The rate of thrombin can be a degree of 0.1-500 unit (U) with respect to the polypeptide in the hemostatic material. A binder component having in vivo decomposing and absorbing property can be contained in the hemostatic material. The material can be formed on a base material.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a gene of nontypeable strain of Haemophilus influenzae (NTHi) and uses thereof.  &lt;P&gt;SOLUTION: The polynucleotide sequence of a nontypeable strain of Haemophilus influenzae (NTHi) is provided. The polypeptide encoded by the polynucleotide and uses thereof are provided. The NTHi genes which are upregulated during or in response to NTHi infection of the middle ear or the nasopharynx are provided. The use of the NTHi polynucleotide and the NTHi polypeptide includes vaccine and a method of treating and preventing NTHi-associated disorders.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
PURPOSE:To obtain the titled water-soluble extract by extracting the water- soluble component from a vegetable oil such as soybean oil, concentrating the extract, mixing with concentrated alcohol to a specific alcohol concentration, removing insoluble materials from the mixture, and removing the alcohol from the product. CONSTITUTION:A water-soluble liquid extracted from a vegetable oil such as soybean oil, corn oil, etc. is concentrated. The concentrate is mixed with concentrated alcohol to attain an alcohol concentration of &gt;=85%, and insoluble materials are removed from the mixture. The alcohol is removed, and the active component is concentrated to obtain a water-soluble extract. The extract is added with water, treated with activated charcoal, and adjusted to a saccharinity of 50%. The precipitated magnesium lactate and inorganic salts are removed, and the mother liquor is dried to obtain the substance effective to hypertension, etc. as white powder. The substance exhibits the characteristic color development of sugar by alpha-naphthol reaction and orcinol reaction, and is negative to TCA reaction, etc. and positive to glycyrrhizin reaction. The hydrolyzed product has certain similarity to glucose and sorbose.
PURPOSE:To provide granules good in feeling when taken, quickly manifestative in medicinal virtues, made up of inner layer comprising an active ingredient and outer layer with a water-soluble polymer and saccharide dispersed therein. CONSTITUTION:The objective granules made up of (A) inner layer comprising an active ingredient giving offensive feelings such as bitter taste or irritation and (B) outer layer applied on the inner layer and comprising a water-soluble polymer (e.g. hydroxypropyl cellulose) and a saccharide (e.g. white sugar). The amounts of the water-soluble polymer and saccharide to be formulated are 1-50 pts.wt. based on the final granules and 50-2000 pts.wt. based on the polymer, respectively. Since the bitter or irritative medicinal substance is coated with both the water-soluble polymer and saccharide, when the granules are taken in the mouth, the saccharide is melted by the saliva, manifesting sweet taste, and the polymer is gelled, covering the inner layer, thus masking bitter taste or irritativity. On the granules&#39; passing through the mouth, the medicinal substance&#39;s melting begins, its medicinal virtues being quickly manifested. Thus, the granules can easily be taken by the old, infants, or children.
PCT No. PCT/EP91/02495 Sec. 371 Date Feb. 25, 1994 Sec. 102(e) Date Feb. 25, 1994 PCT Filed Dec. 21, 1991 PCT Pub. No. WO92/11279 PCT Pub. Date Jul. 9, 1992.New D-homo-(16-ene)-11 beta -aryl-4-estrenes of general formula I    &lt;IMAGE&gt;  (I)  as well as their pharmaceutically compatible addition salts with acids are described in which X stands for an oxygen atom, the hydroxyimino grouping &gt;N DIFFERENCE OH or two hydrogen atoms, R1 stands for a hydrogen atom or a methyl group, R2 stands for an hydroxy group, a C1-C10 alkoxy or C1-C10 acyloxy group, R11 stands for a fluorine, chlorine or bromine atom, and then R12 and R13 together mean an additional bond or R11 stands for a straight-chain or branched-chain C1-C4-alkyl radical or a hydrogen atom, and then R12 and R13 each mean a hydrogen atom or together mean an additional bond, and R3 and R4 have the usual meanings indicated in the description for competitive progesterone antagonists. The invention further relates to a process for the production of new compounds, pharmaceutical preparations containing these compounds, their use for the production of pharmaceutical agents as well as the new intermediate products necessary for the process. The new compounds have a strong affinity to the gestagen receptor and show strong antigestagen as well as antiglucocorticoid, antimineral corticoid and antiandrogenic properties.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an NMF (natural moisturizing factor) production promoter promoting the NMF production in an epidermal cell, raising the moisture retention functions of a horny layer and ameliorating drying or pruritus of skin.  &lt;P&gt;SOLUTION: This NMF production promoter comprises an extract from one or two or more species selected from Leonurus sibiricus L., Prunus armeniaca L. or Prunus armeniaca L. var. ansu Maximowicz, Lonicera japonica Thinberg, Asiasarum heterotropoides F. or Asiasarum sieboldi F., Angelica sinensis Diels or Angelica acutioba Kitagawa, Coix lacryma-jobi Linne var. ma-yuen Stapf, Prumus persica Batsch or Prumus persica Batsch var. davidana Maximowicz, Rubus suavissimus Shugan Lee and Tremella fuciformis B. The NMF production promoter raises the moisture retention functions of the horny layer and exhibits effectiveness in ameliorating the drying or pruritus of the skin by formulating thereof in a food, a cosmetic, quasi-drug or a medicine, and the like, and promoting the NMF production in the epidermal cell.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
FIELD: agriculture, veterinary science. SUBSTANCE: method involves administration to calves the probiotic &#34;RAS&#34; obtained on the basis of culture Bacillus subtilis by method of genetic recombinations. Probiotic is given to animals by oral route at the dose 1-4 ml/head, once per a day before morning feeding for 10 days. Method can be used for normalization of growth and development of newborn calves, enhancement of biological tone and resistance to diseases in the early age. EFFECT: improved method of breeding. 2 cl, 1 tbl, 2 ex
PURPOSE:To obtain an emulsified dispersion with high stability, storage stability, etc. by using modified PVA prepd. by saponifying a copolymer consisting of the specific three components as an emulsifying and dispersing agent for lipophilic nonaqueous materials. CONSTITUTION:The modified PVA prepd. by saponifying the copolymer of the three components; a monomer such as vinyl ester of fatty acid of &gt;=5 carbon numbers such as vinyl valerate, vinyl ether of alkyl groups of &gt;=4 carbon numbers such as butyl vinyl ether or the like, the monomer of the general formulaI (where R1=H or a lower alkyl group, R2= an alkyl group, R3-5=H or an alkyl  group, M= one equiv. of hydrogen or cation) and vinyl acetate is used as an  emulsifying and dispersing agent for liphophilic nonaqueous materials. The resultant emulsifying and dispersing agent has high stability, and outstanding  storage stability, mechanical properties, etc.
Pectin hydrolysis products are produced by the two-stage hydrolysis of a pectin or pectin-containing plant material with pectin-hydrolysing enzymes. Production of pectin hydrolysis products comprises: (a) treatment of a pectin or pectin-containing plant material in aqueous solution or suspension with a pectin-hydrolysing enzyme (A); and (b) treatment of the product with a pectin-hydrolysing enzyme (B). The products obtained contain galacturonides with at least one 4,5-unsaturated galacturonic acid molecule and are esterified with methanol to &gt;= 20%. An independent claim is also included for a pharmaceutical or dietetic preparation containing the pectin hydrolysis products and a carrier. ACTIVITY : Antibacterial. No data is given. MECHANISM OF ACTION : None given in the source material.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for reproducing a protein, a water-soluble formulation of TFPI (tissue factor pathway inhibitor), a method for modifying a solubility of a protein by using a charged polymer, and so on.  &lt;P&gt;SOLUTION: The method for modifying a solubility of a protein uses a polyionic polymer. This polyionic polymer promotes the solubilization, formulation, purification and reproduction of a protein, especially a protein which has been accidentally folded and a protein which has aggregated. The composition suitable for the formulation of TFPI is disclosed. The use of this composition allows to prepare the composition of TFPI which is permissible as medicines having a concentration of 0.2 mg/ml or more as well as that of 10 mg/ml or more.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
The invention relates to a preparation method of a preparation for treating breast cancer. Breast cancer is a normal malignant tumor, in the recent years, the breast cancer patients become younger and younger, and the reason may relate with the environment and food (pesticide). In the early stage, the breast cancer is hard to detect, and thus the breast cancer harms women&#39;s health badly. The provided preparation is developed by combining the traditional Chinese medicine syndrome differentiation principle and modern biological technology. The anticancer active substances are extracted from woodlouse and scorpion, and are capable of inhibiting the growth of cancer cells. Moreover, components having the functions of strengthening body resistance, eliminating evil, resolving stasis, and activating blood are extracted from poria cocos and radix codonopsis. The preparation for treating breast cancer can effectively and radically treat breast cancer and at the same time strengthen the human immunity.