anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
NEW MATERIAL:The compound of formula and its salt, having the following characteristics. Appearance and nature, amphoteric white powder; experimental formula, C13H21N3O6; molecular weight, 315; color reactions, positive to ninhydrin reaction and xanthoprotein reaction; solubility, easily soluble in water, and hardly soluble in methanol, ethanol, acetone, etc.; melting point, &gt;=200 deg.C. USE:Carcinostatic agent and antimycotic agent. PREPARATION:A microbial strain belonging to Streptomyces genus and capable of producing G0069 substance (FERM BP-706) is cultured preferably in a liquid medium under aeration and agitation at 25-40 deg.C usually for 50-100hr. The microbial cells are removed from the culture liquid by filtration, and the objective substance is separated and purified from the filtrate by conventional method. The cultivation under aeration and agitation is carried out preferably by stirring the medium at a revolutional speed of 200-400rpm while blasting sterilized air at a rate of 0.3-0.6pt.vol/min per 1pt.vol. of the nutrient medium.
The invention discloses a kind of method of the extract total alkaloids from shepherd&#39;s purse, its operating procedure is as follows：1. pretreatment of raw material, shepherd&#39;s purse is crushed and powdered makees raw material for standby；2. weigh above-mentioned Shepherdspurse herb to be wrapped with filter paper, put in apparatus,Soxhlet&#39;s, a few hours are heated to reflux after adding ethanol, ethanol extract is evaporated on the rotary evaporator, the jelly for extracting is poured into beaker with distilled water diluting, add watery hydrochloric acid regulation pH value, stir, filter；3. filtrate again ammonification water regulation pH value, with chloroform extract, collect chloroform layer, with Rotary Evaporators reclaim chloroform, residue be coarse biometric alkali；4. alkaloid crude product is poured into beaker, with distilled water diluting, and pH value is adjusted with watery hydrochloric acid, extracted with ether and remove depigmentaton, discard ether layer；5. ammoniacal liquor regulation pH value is added in water layer, then is extracted with chloroform, merge chloroform layer, evaporated with Rotary Evaporators and reclaim chloroform, residue is purer alkaloid.This method has the advantages that yield is high, purity is high, extraction rate is fast, is adapted to industrialized production, has broad application prospects.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an antiinflammatory agent, a beautifying and whitening agent, or an anti-ageing agent comprising extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae, and a skin cosmetic comprising these.  &lt;P&gt;SOLUTION: The antiinflammatory agent comprises extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae. The beautifying and whitening agent comprises the extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae. The anti-ageing agent comprises the extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae. The skin cosmetic comprises as effective ingredients extracts of Polygonum filiforme belonging to the genus of Polygonum of the family of Polygonaceae.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
PURPOSE:To provide the titled base containing casein and/or its salt, urea, and water as main components, capable of keeping high adhesivity for a long period, peelable without leaving the plaster on the skin, resistant to sagging with sweat because of high water-retainability and having little temperature dependency of the properties. CONSTITUTION:The titled base contains 0.5-10wt% casein and/or its salt, 0.5-20% urea, and 5-80% water as main components. The base has strong adhesivity to the skin, and is peelable from the skin without leaving the plaster on the skin because of strong autohesive power, free from the flow-out of the plaster with water, and resistant to sagging by the softening of the plaster at a high temperature. Any casein produced from various animal milk as well as cow&#39;s milk meets the purpose. Various proteins (e.g. gelatin, albumin, etc.) can be added to casein. The characteristic of the above base can be maintained stably at 5-8pH.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a cleansing agent which is reduced in the probability of stimulated expression, by elucidating the mechanism of the expression of stimulation in the cleansing agent.  &lt;P&gt;SOLUTION: The foam for cleansing the skin is prepared by foaming an aqueous cleansing agent and the form in which fatty acid amount per mL volume is ≤0.01 g is selected for cleansing. The foam is preferably that being used for cleansing a sensitive skin. In the foam, lowering of horny layer barrier function in cleansing behavior is suppressed. In average use aspect, the foam is obtained by including a foaming means as a constituent into an aqueous cleansing agent. A foaming net, a pump foamer or a foam aerosol by gas component is preferably used as the foaming means.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a medicine for curing or preventing inflammatory bowel diseases (IBD) such as ulcerative colitis.  &lt;P&gt;SOLUTION: The inventor found for the first time that bowel inflammation can be efficiently inhibited by inhibiting the formation or accumulation of chondroitin sulfate proteoglycan. That is, by inhibiting the expression of versican which is one of the chondroitin sulfate proteoglycans using siRNA, inflammation in the large bowel could be inhibited. A compound such as a nucleic acid to be used for such an siRNA can be used as an agent effective in the inhibition of bowel inflammation. Further, this also indicates that the agent for inhibiting bowel inflammation can be found by screening a compound inhibiting the formation or accumulation of chondroitin sulfate proteoglycan.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
An osmotic device (10) for the controlled systemic delivery of nicotine through an oral mucosal membrane of a human patient is disclosed. The device (10) has a size and shape adapting it to be comfortably retained in the mouth for extended periods of time. The device (10) comprises a semipermeable wall (12) surrounding a compartment (13) containing a nicotine salt (14) and optionally an alkaline salt which is capable of reacting with the nicotine salt in the presence of water to form nicotine base. The conversion of nicotine salt to nicotine base may take place within the device (10) and/or outside the device and in the patient&#39;s mouth. Nicotine base and/or salt is delivered from the compartment (13) through a passageway (17) in the wall (12). The nicotine salt exhibits good stability and shelf life while the nicotine base exhibits excellent absorption through oral mucosal membranes.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide dog food preventing dogs from suffering from joint disorder or herniated disk.  &lt;P&gt;SOLUTION: The dog food comprises being mixed with heat-resistant vitamin C (L-ascorbic acid-2-phosphate-ester magnesium), glucosamine and chondroitin. Production of collagen is promoted by refilling vitamin C when giving the dog food in a period of puppy to the beginning of adult dog even if vitamin C is consumed by production of anti-stress hormone because of the environment with much stress. As a result of this, a dog grows to be a strong dog with firmly formed cartilage and intervertebral disk. Glucosamine and chondroitin perform growth promotion, fracture prevention and restoration of damage of cartilage.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
PURPOSE:To provide the subject derivative containing the octapeptide unit of formula Glu-I le-Leu-Asp-Val-Pro-Ser-Thr, having activity to inhibit the adhesion of animal cell and the coagulation and cohesion of platelet and useful for suppressing cancer metastasis. CONSTITUTION:The objective peptide derivative of formula II ((n) is 1-3) or its salt can be produced by reacting a dialkyl (diacyl) glycerol (e.g. 1,2- dihexadecylglycerol) with a cyclic acid anhydride (e.g. succinic anhydride) in an organic solvent capable of dissolving the above components (e.g. methylene chloride) in the presence of a base at room temperature to obtain a dialkyl (diacyl) glycerol derivative of formula I (R&lt;1&gt; and R&lt;2&gt; are H, 8-24C acyl or alkyl;(m)is 1-5), separately preparing a protected peptide by successively bonding protected amino acids according to the amino acid sequence of the objective peptide in the presence of a condensation agent and condensing the above compound with the protected peptide in the presence of a carbodiimide in an organic solvent (e.g. chloroform) at room temperature.
FIELD: cosmetology. SUBSTANCE: a cosmetic gel stick contains a liquid carrier, antiperspirant salt diluted in a carrier, dibenzylidene aldite, hydroxyalkylcellulose and/or a chelate component. The suggested stick contains (weight%) 70-95% liquid carrier, 1-22% antiperspirant salt diluted in a carrier, 0.5-3% dibenzylidene aldite, 0.1- 0.5% hydroxyalkylcellulose and 0.05-3% chelate component. A liquid carrier includes a polyatomic alcohol and alkali, such as sodium or potassium hydroxide. The suggested stick has got pH above 4.7, turbidity below 100 NTU and hardness ranged within 60-150. Due to decreasing the content of dibenzylidene aldite it is possible to improve the stick&#39;s transparency and flavor. Stick&#39;s hardness is maintained due to addition of hydroxyalkylcellulose. Its color is improved as a result of chelate component supplementation. EFFECT: improved properties. 22 cl, 9 ex
Apparatus for the creation, editing and utilising a knowledge base which contains textual information, quantitative information and pictorial images. A computer system comprised of text and image input devices, a display, a mass storage unit for the knowledge base and a programmed processor. When used as an expert authoring system, for example, in medical applications, features which are characteristic of respective conditions in a disease are established by the author and values are assigned thereto, thus creating a knowledge base of features having associated values. This created information is used by the author to evaluate what he observes in a patient or histological sample. The &#34;valuing&#34; of these previously established features within the parameters for values that also were established previously form a case record that also includes one or more pictorial images of valued features. The retrievability of case records and editing of valued features insures internal consistency of the knowledge base.
An influenza Status Registry (ISR) that provides a method of acquiring, storing and displaying a person&#39;s status regarding influenza, particularly the COVID-19 coronavirus, as well as vaccination information. The ISR uses a software program that operates on a computer or a wireless device such as a smart phone or tablet computer. A person will have an influenza/COVID-19 test performed by a medical professional. The test results, which show the person&#39;s status, are then displayed on the computer or wireless device. Any business or other entity where multiple people congregate in a limited space then uses the ISR to determine if it is safe to allow each person to enter the location. The status will be displayed as never had, previously had or currently has influenza/COVID-19, and appropriate action can be taken based on the test results. Additionally, the ISR will display information pertaining to a person&#39;s vaccination status.
PURPOSE:To obtain a visible image by coherent light of laser light, etc. by providing a photoreceptive layer consisting of a specific Si photosensitive layer and surface layer having multi-layered constitution on a base and arranging many non-parallel boundary faces in the direction perpendicular to the layer thickness within the very small part thereof. CONSTITUTION:The photoreceptive member 100 provided with the photoreceptive layer having the photosensitive layer 102 consisting of an amorphous material incorporated therein with Si and Ge or/and An and the surface layer 103 of the multi-layered constitution having at least a wear resistant layer on the outermost shell and an antireflection layer in the inside on the base 101 has &gt;=1 pairs of the non-parallel boundary faces in the short range in the photoreceptive layer (very small part within one period of a rugged shape: SR). Such non-parallel boundary faces are arranged in &gt;=1 directions within the plane perpendicular to the layer thickness direction. Since such surface layer 103 is provided, the reflection of the incident light at the boundary faces of the layer 103 and the layer 102 is prevented. The generation of the interference patterns and uneven sensitivities arising in the stage of forming the surface layer or from the uneven layer thickness by wear is thus prevented.
Recombining plasmid (A), allowing transformation of a bacterial host and its use as a cloning vector, comprises (a) a regulon (R) homologous to the bacterial host in its non-transformed state, and (b) in &#39;reading phase&#39; with R an inserted DNA which codes for the amino-acid sequence of a heterologous polypeptide (I). Bacteria transformed with (A) can express this amino-acid sequence in a recoverable form. Also claimed are the plasmids, cloning vectors, transformed bacterial cultures and polydeoxyribonucleotides consisting of the codons for (I). Used esp. where (I) is a mammalian hormone or intermediate e.g. human pre-pro- or pro-insulin; insulin chains A or B; luteinising hormone; human or bovine growth hormones; ACTH; pancreatic polypeptide or somatostatin. Immunogenic substance contg. polypeptide haptens can also be produced.
The specification discloses a method, a device, a storage medium and electronic equipment for information display. First, the patient&#39;s visit text data and the patient&#39;s medical image data are acquired. And secondly, selecting a knowledge graph corresponding to a target operation scheme to be executed of the patient from knowledge graphs corresponding to various operation schemes constructed in advance, and taking the knowledge graph as a target knowledge graph. Then, for each surgical risk corresponding to the target surgical scheme, the diagnosis text data, the medical image data and the target knowledge graph are input into a pre-trained prediction model corresponding to the surgical risk, and the probability that the surgical risk occurs to the patient when the target surgical scheme is executed is predicted. And then constructing a fusion knowledge graph corresponding to the patient. And finally, displaying the fusion knowledge graph. The method can improve the communication efficiency between doctors and family members.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a liquid cosmetic composition containing a uniformly and stably dispersed coloring material of a black color.  &lt;P&gt;SOLUTION: This liquid cosmetic composition contains (1) water in an amount of 50-90 wt% and (2) charcoal in an amount of 1-10 wt%. The charcoal is so controlled as to have an average particle diameter of 0.05-1 μm. The charcoal preferably comprises officinal charcoal specified by Japanese Pharmacopeia. The charcoal is preferably formed by grinding and dispersing a charcoal powder of which the particle diameter is distributed in a range of 10-100 μm with at least two kinds of vehicles having diameters different from each other in the presence of an aqueous carrier by using a sand mill. The liquid cosmetic composition is preferably free from carbon black.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
FIELD: chemical-pharmaceutical industry, phytopreparations showing antibacterial activity. SUBSTANCE: Saint-John&#39;s-wort herb is subjected for firstly extraction with acetone. Plant raw remained after extraction is dried and extracted with 70% ethanol at ratio 1:10 by percolation method. Plant raw remained after extraction with 70% ethanol is dried and then extracted with 30% ethanol at ratio 1:10. Obtained extracts were combined and dried. EFFECT: high yield of bioactive substances showing antibacterial activity.
PURPOSE:To obtain a specific medicine for athlete&#39;s foot, by drying and crushing both or either one of SUGI (Japan Cedar) leaves and pine leaves to give a powdery or granular material, dipping the resultant powdery or granular material in acetic acid solution to swell the material. CONSTITUTION:SUGI leaves or pine leaves are collected dried thoroughly in the sun or in a dryer, and the dried leaves are crushed into a powdery or granular material in a crusher, etc. The resultant powdery or granular material is then dipped in an acetic acid solution, preferably an aqueous solution of about 3- 8wt% concentration and swelled to give the aimed agent. The mixing weight ratio between the aqueous solution of the acetic acid and the SUGI or pine leaves is about 6:4, and the powdery or granular material is dipped in the aqueous solution and allowed to stand for 2-3 days for swelling. The above-mentioned agent is applied uniformly to the affected part, and covered with a bandage,. etc. to permeate the active constituent into the affected part for about a half day. The resultant dried coated surface is removed to cure completely the itching of the skin and expel the trichophytes. The resuscitation of the skin in the state close to the natural cure is carried out without disavantages of damaging the skin by excessive irritation.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a wet sheet which readily wipes out dried stool and sticky dirt, and prevents rash and inflammation of the skin.  &lt;P&gt;SOLUTION: The wet sheet, which has a sheet base material with a water retention property impregnated with liquid, is impregnated with the liquid in an amount of 300-600 wt.% based on the weight of the sheet base material. An anti-inflammatory agent is employed as the liquid, and the anti-inflammatory agent is blended in an amount of 0.02-1.0 wt.% based on the total weight of the liquid. The sheet base material has a three-layered structure of a middle layer, and front and back layers. A single layer of hydrophilic fibers is used for the middle layer, and a layer containing hydrophilic fibers in an amount of at least 60% is used for the front and back layers, respectively.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for culturing for solid culture of Zang Zhi, a solid cultured product obtained from the method for culturing, a processed product of the solid cultured product and uses thereof.  &lt;P&gt;SOLUTION: The method is to culture the slid Zang Zhi. The method comprises a step of inoculating a hyphal mass into a Bag Log and culturing the hyphal mass into a mycelium and a step of removing the Bag Log and completely exposing a sawdust culture medium to air during a period until a conical fruit body is formed. The Bag Log comprises the sawdust culture medium containing 10-70% of a cellulose derivative substance, 10-30% of a starch supply source, 5-15% of grains, 1-10% of a saccharide, 0.5-2% of a phosphate and 0.1-1% of a sulfate. The relative humidity is maintained at 60-80% and the pH of the culture medium is regulated to neutral.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
PURPOSE:To obtain a liposome, composed of a long-chain active amide and a lipid capable of forming the liposome, useful as drug carriers, immulological analytical reagents, etc., and capable of modifying surfaces. CONSTITUTION:The objective substance is obtained by mixing &lt;= 50 wt.% compound expressed by the formula [R1 is hydrophobic group; R2 and R3 are organic group (including H) or R2 and R3 may be linked to form a ring or double bond; X and Y are O or S] with a liposome constituent material and preparing a liposome according to a well-known method. The existing lipids except phosphatidylethanolamine and phosphatidylserine which are used as the constituent material of the liposome are cited as the constituent material of the liposome. Examples thereof are egg yolk lecithin and dipalmitoylphosphatidylcholine. Surface-modified liposomes immobilizing various substrates can be readily obtained by mixing the aforementioned lioposome with the substrates (e.g. amino acid-containing peptides or antigen- or antibody- containing proteins) having amino groups and/or thiol groups.
&lt;P&gt;PROBLEM TO BE SOLVED: To display the medical records of a patient continuously, and to create the medical records at any time during a medical examination.  &lt;P&gt;SOLUTION: When a patient is selected on a patient selection screen (not shown), a screen 40 for the medical records of the patient is displayed. A patient basic information display section 41 for indicating the related information of the patient, a section 42 for displaying observation information for entering the observations of a doctor, and an order display section 43 for entering a prescription, guidance, or the like are provided on the medical records screen 40. References, such as patient information and inspection results, to be referred to in a medical examination are superposingly displayed on the order display section 43 as a reference display section 45, and the section 42 for displaying information on the observations is being displayed as it is. As a result, the doctor can create medical records while seeing the references.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
The present invention relates to a keratinocyte growth factor fragment, KGFdes1.23, that is composed of a portion of an amino acid sequence of mature, full length keratilnocyte growth factor, KGF163. The portion possesses at least a 2-fold increaso in mitogenic activity as compared to a mature, recombinant keratinocyte growth factor, rKGF, but lacks a sequence comprising the first 23 amino acid residues, C-N-M-T-P-E-Q-M-A-T-N-V-N-C-S-S-P-E-R-H-T-R-of the KGFI63 N-terminus. The present invention also relates to a DNA molecule encoding KGFdes?-23, an expression vector and a transformed host containing the DNA molecule, and a method of producing KGFdes1-23 by culturing the transformed host. The present invention further relates to a conjugate of KGFdes1-23 and a toxin molecule, and the use thereof for treatment of hyperproliferative disease of the epidermis. Moreover, the present invention relates to a therapeutic composition containing KGF des1-23 and a pharmaceutically acceptable carrier and the use thereof for wound healing purposes. KGFd&#34;l 23 and a 1&#39; lly r F &#39;I carrier and the use thereof for wound hoaling purposes.
The invention discloses an organotin-tetraphenyl ethylene acylhydrazone compound with aggregation-induced emission (AIE) characteristics, a preparation method and anticancer application thereof. The structural formula is shown in formula (I), and R is phenyl, chlorine, bromine or iodine. By testing the growth inhibition rate of the target compound on human alveolar basal epithelial cancer cells (A549), cervical cancer cells (Hela) and human lung normal epithelial cells (BEAS-2B), and comparing the results, the target compound shows potential anticancer activity. The anticancer activity of the compound is effectively improved along with substituent Rphenyl- &amp; gt iodine- &amp; gt bromine- &amp; gt chlorine. In addition, the target compounds exhibit unique AIE luminescence properties and higher solid state absolute fluorescence quantum yields. The target compound can target mitochondria of A549 cells, and lead to the reduction of mitochondrial membrane potential and show anticancer activity.