anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
The invention relates to a method for preparing insulin dry powder for oral administration from insulin and derivatives thereof and an application thereof, and solves the problems that insulin is easy to oxidize, can not be orally administered and is inconvenient for carrying. The method comprises the following steps: heating insulin and derivatives thereof (any content), a propolis antioxidant or a colloidal matter, vitamin E, vitamin C or derivatives thereof, fatty acid and an emulsifier, emulsifying in a sealed condition, and performing spray-drying to obtain insulin dry powder for oral administration. The insulin dry powder for oral administration is administered with water at a proportion at half hour before meal, and can replace synthesized insulin and derivatives thereof or other antihyperglycemic agents for intramuscular injection. The method adopts the advanced &#39;micro capsulation&#39; principle in bioengineering, and basically solves the problem of insulin oxidation through spray embedment of insulin. The insulin dry powder can gradually stimulate slow recovery of islet cells of patients by use of the active substances of a natural propolis antioxidant while supplementing external insulin and derivatives thereof. The insulin dry powder produced by using the method provided by the invention has good oxidation resistance and low production cost, and is easy for carrying and large-scale production. Compared with the prior art, the method conducts oxidation resistance treatment of insulin by using the principle of bioengineering. The method provided by the invention can be widely used in pharmaceutical industry, and brings in the most essential progress for the relief and recovery of diabetic patients.
The invention belongs to health caring medicine domain, supplying selenium and germanium as biologic trace element and immunocyte component to human body to enhance the function of immunocyte, therefore the immunity and the ability against disease are enhanced. The invention can prevent and cure highly pathogenic avian influenza, as well as can be admitted to patients in the form of jujube tea paste by taking tea and eating paste. The high concentration is sustained for 24 hours, so that the course of diseases is greatly shortened, wiht a good name&#39; haodekuai (quick)&#39;. The economic benefit and social benefit are all good.  The status is changed that killing the goose that lays the golden eggs destructively attacks the birds. The invention promots the health growth and development of birds, greatly promots the development of fish breeding and poulitry raising and obtains the desired econimic effect.
PURPOSE:The titled tape or sheet, obtained by using a base material prepared by bonding an extensible woven or knitted fabric to an extensible plastic film with a pressure-sensitive adhesive, capable of extending according to the movement of the skin with the tape or sheet applied thereto, and having airtightness. CONSTITUTION:A remedial adhesive tape or sheet obtained by using a base material prepared by bonding an extensible woven or knitted fabric 1 to an extensible plastic film 3 with a pressure-sensitive adhesive 2 and an adhesive layer 4 for application to the skin, positioned on the plastic film side of the above-mentioned base material, and containing a remedial agent. The above- mentioned woven or knitted fabric 1 has &gt;=40% elongation in at least one of the longitudinal and lateral directions and &lt;=200g/cm tension at 20% elongation. The adhesive in the above-mentioned adhesive layer 4 contains &gt;=60wt% polymer of an alkyl acrylate, etc. The tape or sheet will not be peeled even by the movement of the skin nor deteriorating the extensibility by the application for a long term nor excessive stretching of the surface. Thus, a wound or KABURE (rash) is hardly caused.
The invention relates to a method for pre-doctor diagnosis of a person on the basis of indices of the electrical resistance of the skin and to a method for pre-doctor resonance therapy. In order to carry out a diagnosis, areas of the skin cover for mounting 2-6 sensors in biologically active areas (BAA) are predetermined. The electrical resistance is measured using a combined connection of the sensors to the BAA and changing the polarity of test signals. The biological signals picked up are processed, both from each sensor individually, and also by synchronizing the signals between the sensors, thus simulating a process of &#34;electronic anamnesis&#34; with a tolerance of the diagnostic results of 2-3%. A pre-doctor diagnosis is formed on the basis of the relationship of the following indices: the overall number of measurements in a patient database, the overall number of matches of measurements in the patient database, the number of individual matches of measurements with measurements of patients from the database who have a confirmed diagnosis, and error rates. In order to carry out pre-doctor therapy, a frequency range of the pathology is determined on the basis of the results of the pre-doctor diagnosis, and a therapeutic action is carried out on the patient by creating a frequency resonance. Furthermore, the resonance error is not more than 0.03-0.06% of the measured value, and the duration and/or periodicity of exposure is established on the basis of the &#34;electronic anamnesis&#34; data.
The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer&#39;s disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3β or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3β protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3β protein or GSK-3β protein complexes.
PURPOSE:To obtain a carrier which can be preserved for a long period of time by adjusting a soln. contg. gelatin, water soluble polysaccharides, sodium polymetaphosphate, as well as a hydrophilic org. solvent and water in a specific pH range by adding acids thereto to form particles then cooling the same to temp. lower than specific temp. and effecting crosslinking agents therewith. CONSTITUTION:Acids (acetic acid, etc.) are added to a soln. contg. gelatin, water soluble polysaccharides (gum arabic, etc.), sodium polymetaphosphate, and a hydrophilic org. solvent (alcohol, etc.) and water under stirring at temp. higher than the gelling temp. of the gelatin to adjust 2.5-6.0pH and to form a dispersion of gel particles. After the formation of the particles, the soln. is cooled and when the temp. thereof drops to &lt;=10 deg.C, crosslinking agents (glutaraldehyde, CH3CHO, etc.) are added thereto to obtain crosslinked particles. The crosslinked particles are centrifugally separated and washed, whereby the carrier to be deposited thereon with antigens, etc. for serodiagnosis, etc. is obtained. This carrier is obtained in optional grain sizes according to production conditions, is good in yield, permits preservation for a long period of time and is usable anytime without liberation of antigens, etc. even when the carrier is bound with the antigens, etc. and is frozen and preserved.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a single component liquid pharmaceutical composition for administration to a mucosal surface, able to gelate at a site of application or be constituted to gelate.  &lt;P&gt;SOLUTION: The liquid pharmaceutical composition comprises a therapeutic agent and a pectin with a low degree of esterification and gelates at the site of application in a condition of the absence of an extraneous source of divalent metal ions. The mucosal surface is preferably the nasal cavity, the vagina, the rectum, the back of the throat or the eye. The degree of esterification is &lt;50%. The concentration of pectin is 1-100 g/L. The therapeutic agent is an antiviral agent, a vaccine, a decongestant, a contraceptive or the like.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a means for neutralizing development of toxicity, for the purpose of curing gastritis, a gastric ulcer, etc., caused by Helicobacter pylori.  &lt;P&gt;SOLUTION: A binder to a vacuolation toxin VacA of the Helicobacter pylori comprises at least one kind selected from a group consisting of ganglioside, a lyso form thereof, and a chemically modified product thereof (ganglioside and the like) as an active ingredient. A method for treating or preventing a disease in which the bacterium participates comprises neutralizing VacA activity by using the binder to the VacA. A method for screening a remedy or a prophylactic for the disease in which the bacterium participates comprises using the binder to the VacA and the Vac A. At least one kind of compound selected from the group consisting of the ganglioside and the like is used for producing the remedy or the prophylactic for the gastritis, the gastric ulcer, and a gastric cancer. A food for controlling action of the bacterium contains at least one kind selected from the group consisting of the ganglioside and the like.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
1,171,183. Compositions containing enzymes. CENTRE D&#39;ETUDES POUR L&#39;lNDUSTRIE PHARMACEUTIQUE. 12 Jan., 1967 [20 Jan., 1966], No. 1785/67. Heading A5B. Pharmaceutical compositions, having antiinflammatory and anti-oedematous activity, comprise a mixture of amylase and lysozyme (muramidase) together with a pharmaceutically acceptable vehicle. The amylase may be of bacterial, animal or vegetable origin, suitably being prepared from mushrooms. Lysozyme, which may be found in nasal mucus, saliva, tears, human milk or egg white, is suitably prepared from the latter, in aqueous solution, by absorption on bentonite, with elution of the enzyme with aqueous pyridine of pH 5.0, followed by precipitation with ammonium sulphate, dialysis and desiccation of the product. The compositions preferably also contain chymotrypsin, and mucopolysaccharidases (chondrosulphatase and hyaluronidase), or other depolymerising or hydrolytic enzymes. They may be in the forms for oral or topical administration, such as tablets, coated tablets, sublingual tablets, syrup, unit dosage packets, ointments, or spray solutions for use in an atomiser.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a skin melanocyte proliferation inhibitor, a sunscreen agent and a bleaching agent, to prepare a sunscreen cosmetic or a bleaching cosmetic.  &lt;P&gt;SOLUTION: The melanocyte proliferation inhibitor utilizing an information-communicating mechanism from skin epidermal cells is characterized by containing an extract of Paeonia Lactiflora Pallas and/or Zizyphus jujuba Miller var. inermis Rehder. The sunscreen cosmetic or bleaching cosmetic contains the extract of Paeonia Lactiflora Pallas and / or Zizyphus jujuba Miller var. inermis Rehder as the melanocyte proliferation inhibitor.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
High affinity relaxin receptors, polypeptide compositions related thereto, as well as nucleotide compositions encoding the same, are provided. These proteins, herein termed LGR7 and LGR8, are orphan leucine-repeat-containing, G  protein-coupled receptors. These receptors have a wide and a unique tissue expression pattern. The receptors, particularly soluble fragments thereof, are useful as therapeutic agents capable of inhibiting the action of relaxin and InsL3. The receptors and fragments thereof also find use in the screening and design of relaxin agonists and antagonists. Conditions treatable with relaxin agonists or antagonists include prevention or induction of labor, treatment of endometriosis, treatment of skin conditions such as scleroderma that require collagen or extracellular matrix remodelling. Additionally, relaxin has been implicated in the dilation of blood vessels&#39; smooth muscle cells directly and through release of nitric oxide and atrial natriuretic peptide. Relaxin has also been used in the treatment of severe chronic pain, particularly pain arising from stretching, swelling, or dislocation of tissues.
The present invention provides medicine for treating neonatal jaundice and a taking method thereof, which relates to the field of traditional Chinese medicine. In order to solve the problems of high risk and obvious side effect on the aspect of treating neonatal jaundice in the prior art, the present invention provides the medicine having the advantages of high safety and high efficiency for treating neonatal jaundice. The medicine is prepared from raw materials of the following proportion by weight: 10 to 90% of muskmelon base, 10 to 90% of small centipeda herb, 0 to 70% of Chinese gall and 0 to 20% of borneol. The taking method is realized by putting the medicine for treating neonatal jaundice into neonatal patients&#39; nasal cavities. The medicine avoids harm of oral medicine to neonatal weak viscera by adopting the safe and efficient medicine for external use, and also has the advantage of simple medicine application. The medicine performs favorable functions by taking Chinese medical theories as guidance through the cooperation of medicine; the application of more than 1000 neonatal patients shows that the effective rate of the medicine is as high as 99.9%, and recovery is achieved only by medicine application to nasal cavities at the same time; the bilirubin of more than 80% neonatal patients can restore to a normal range within a week.
Non-reusable, medicament-dispensing applicator electrodes (10) adapted for use with an iontophoresis device or an ionosonic device for facilitating delivery of medication across the cutaneous membrane into adjacent underlying tissues, and blood vessels. The embodiments of the iontophoresis electrode include an open mesh (12) having cells (12a) in the medicament dispensing portions (11) of the electrode which retain a medicament in the form of liquid, gel or ointment. The cells are adapted to contain, to iontophoretically dispense, and deliver medicament. The medicament-dispensing electrodes (70) are composite or unitary in construction and may be useful in the treatment of acne, and also genital herpes simplex infection. The delivery electrode (71), when used in accordance with the medicated electrode, and method described herein, demonstrated &gt; 90 % treatment efficacy in clinical trials for the treatment of genital herpes. The applicator electrode may also be used with an ionosonic handpiece (40).
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a production method of sesame and green wheat granules capable of obtaining a food material excellent in taste, storage stability and beautiful skin effect by combining green leaves of wheats and sesame.  &lt;P&gt;SOLUTION: A dry powder of green leaves of wheats, sesame and food fibers are mixed in a proper ratio to produce a sesame and green wheat compound and this compound is molded into granular shape. In the mixing process, the dry powder of green leaves of wheats and sesame are set to a weight ratio of 5 : 1 to 1 : 2 and sesame is mixed so that sesame becomes at most 30 wt.% in sesame and green wheat granules. In this case, the mixing process includes a process for mixing a vehicle. Further, green leaves of wheats are young leaves of barley.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 5-substituted-3-oxadiazolyl-1,6-naphthyridine-2(1H)-one of the formula (I)   where Het is oxaziazolyl; R 1  is H, lower alkyl, cyclo-lower alkyl, trifluoromethyl, lower alkenyl, lower alkynyl, lower alkoxy-group, lower alkoxy-lower alkyl, hydroxy-lower alkyl, substituted or unsubstituted aryl group or unsubstituted heteroaromatic group; R 2  is H, lower alkyl, lower cycloalkyl, cyclo-lower alkylmethyl, lower alkenyl, cyclo-lower alkenyl, lower alkynyl, substituted to unsubstituted aryl group or unsubstituted heteroaromatic group. Invention relates to also pharmaceutically acceptable additive acid salts that show highly selective affinity to benzodiazepine receptors and they are especially useful, for example, as a psychoanaleptic agent or a medicinal agent for treatment of dysmnesia, senile disease or Alzheimer&#39;s disease. Invention describes also a pharmaceutical composition and intermediate compounds used in synthesis of compounds of the formula (I). EFFECT: valuable medicinal properties of compounds and pharmaceutical composition. 7 cl, 31 tbl, 370 ex
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for producing a new moist cake cosmetic product having excellent definite quantity filling property and giving uniform filling density while suppressing cost increase.  &lt;P&gt;SOLUTION: An inner pan 2 is set in a holding space 1a of a holding member 1 to hold the inner pan 2. A filling nozzle 3 is placed above an opened part of the inner pan 2 held by the holding member 1 without closing the opened part. A slurry filling material is extruded through the filling nozzle 3 into the inner pan 2. Finally, the filling material in the inner pan 2 held with the holding member 1 is pressed without striking the surface of the filling material.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
PCT No. PCT/GB93/00711 Sec. 371 Date Dec. 5, 1994 Sec. 102(e) Date Dec. 5, 1994 PCT Filed Apr. 5, 1992 PCT Pub. No. WO93/20103 PCT Pub. Date Oct. 14, 1993A method of identifying peptides of an antigen of interest which are capable of recognition by or induction of cytotoxic T lymphocytes, comprises the steps of: ascertaining a &#34;motif&#34; of peptides which bind to a chosen HLA class I allele; providing peptides having this motif which are present in the known sequence of the antigen of interest; screening the peptides using an HLA assembly assay; and screening the resulting peptides for recognition by or induction of cytotoxic T lymphocytes. The above peptides have been identified by this method, and the peptides and vaccines containing them are also claimed.
PROBLEM TO BE SOLVED: To prepare a gummy preparation easily takable without using water, effective for masking the bitter taste and disagreeable smell of medicine and capable of improving compliance. SOLUTION: A carbohydrate is heated together with water and mixed with a gelling agent composed mainly of gelatin. A medicine is added to the mixed liquid and optionally an acidulant, a colorant, a flavor, etc., are added to the mixture to obtain a gummy preparation base. The objective gummy preparation is prepared by cooling and solidifying the base. The obtained gummy preparation is usually coated with edible oil and fat or granulated sugar to prevent the agglomeration of the gummy preparation. The gummy composition is a gelatinous candy composition composed of 65-87-wt.% of a carbohydrate, 3-10wt.% of a gelling agent composed mainly of gelatin and 10-25wt.% of water, having Aw (water activity at 20 deg.C) of &lt;=0.7, free from the problem of the proliferation of microorganisms and preservable over a long period.  It can be used as various pharmaceuticals such as antianxiety agent, antiepiletic agent, antipyretic analgesic agent, agent for psychoneurosis, antispasmodic agent, cardiotonic agent, antiarrhythmic agent, diuretic agent, hypotensor, hypolipidemic agent, etc.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a hair growth promoter containing reduced amount of tourmaline powder from the viewpoint of economy and having hair growth promoting effect superior or comparable to conventional agent containing relatively expensive pulverized tourmaline in a viscous product in an amount of as much as 40-50 wt.%.  &lt;P&gt;SOLUTION: The first embodiment of the invention is the use of ultrafine powder of tourmaline having a maximum diameter of ≤10μm and produced by finely pulverizing tourmaline powder sieved with a 325 mesh sieve. The hair growing effect is supposed to be increased by prolonging the retention time of tourmaline on the scalp skin and increasing the activation effect on the scalp skin. An improved viscous product having high dispersibility of fine powder, uniformity and stability can be produced by the use of highly viscous polyethylene glycol 240 in combination with hyaluronate sodium, etc. The content of tourmaline fine powder is reduced to 2-4 wt.% by adding Panax ginseng extract and Swertia japonica extract for promoting the hair growing effect.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
PURPOSE:To obtain a cosmetic for hair restoration and hair growth continuously usable without strong irritation, having excellent effects, containing an active ingredient extracted from a crude drug of Ligustrum lucidum Ait., Angelica dahurica Benth, et Hook, or Curcuma zedoaria Rosc. with a water-insoluble organic solvent or a hydrous solvent thereof. CONSTITUTION:100g crude drug of Ligustrum lucidum Ait., Angelica dahurica Benth. et Hook. or Curcuma zedoaria Rosc. is extracted with 1l organic solvent such as primary alcohol (e.g. methanol or butanol), acetone, THF or dioxane alone or hydrous organic solvent containing &gt;=50wt.% the organic solvent for 2hr each time 3 times, the extracted essence is put together, filtered by suction and concentrated under reduced pressure to give viscous essence of crude drug. 0.5-5.0wt.% of the essence as an active ingredient is directly added to a base or dissolved or dispersed in a proper solvent and diluted and added as the active ingredient to the base to give a promoter for hair restoration and growth.