anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
NEW MATERIAL:A compound of formula I [R&lt;1&gt; is H, alkyl, phenyl which may be substituted;R&lt;2&gt; is H, alkyl;formula II is cyclic amine which may be substituted and may include N, S and O atoms] and its salts. EXAMPLE:6,8-Difluoro-1-methyl-4-oxo-7-(1-piperazinyl)-4H-[1,3]thiazet[ 3,2- a]quinoline-3-carboxylic acid ethyl ester. USE:Antibacterial against Pseudomonas aeruginosa, gram-positive bacteria and gram-negative bacteria. It has low toxicity. It can be used as a therapeutic agent for systemic infection and local infection such as urinary tract infection or biliary tract infection. PREPARATION:The cyclization reaction between a compound of formula III (R&lt;3&gt; is alkyl) and a dihalide of formula IV (Y, Z are halogen) such as methylene iodide is carried out in an inert solvent, in the presence of an acid acceptor at 0-120 deg.C. The compound of formula II, as a starting substance is novel.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an artificial tooth stabilizing agent, and an artificial tooth mounting method, by which a comfortable and favorable artificial tooth mounting state can be kept for a long period without causing pain, ulcers, or inflammation, in such a way as to be especially suitable to a toothless jaw patient.  &lt;P&gt;SOLUTION: The artificial tooth stabilizing agent comprises flexible adhesive having a polyvinyl acetate resin with low fluidity in an amount of 3-9 wt.%, dissolved in room temperature valcanizable (RTV) liquid silicone rubber, of de-acetic acid type. In the artificial tooth mounting method, an artificial tooth, to which the stabilizing agent is applied at a mucous membrane contacting part of an artificial tooth bed, is disposed on the mucous membrane after the mouth is rinsed with a saturated solution of pre-conditioned pharmacopeial sodium hydrogencarbonate to penetrate the mucous membrane. While acetic acid emitted from the artificial tooth stabilizing agent is neutralized, an alveolar ridge is modeled, and then it is taken out of the mouth. After the artificial stabilizing agent is vulcanized, the artificial tooth is mounted on the mucous membrane through the false tooth stabilizing agent.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
FIELD: medicine. SUBSTANCE: this medicinal preparation should be applied to penis skin in the form of ointment for either normalizing or improving sexual potency in males, especially erection. This ointment is effective means of treating vasculogenic, age and psychogenic disorders in erection mechanism and may be applied either once or during cure. Essence of this invention consists in that optimal proportioning of ointment ingredients and dosage of each ingredient and new method of application (external application directly to penis) produce fundamentally new curative effect. This novel ointment includes such components as nitroglycerin, papaverine hydrochloride, zufilline, dimexide, testosterone propionate and ointment base including polar fox fat, aqueous lanolin and aromatic additive, that is, citral oil. Disclosed ointment may be recommended for extensive use in medicinal practice on doctor&#39;s prescription. EFFECT: highly effective remedy helped actually improve sexual potency in 83 % of male patients, it is safe and available for effectively treating erection disorders in males.
PROBLEM TO BE SOLVED: To obtain a synthesis inhibitor capable of effectively improving and curing a physiological state of a patient having an autoimmune disease such as type I diabetes or rheumatoid arthritis by using a readily available specific extract. SOLUTION: This synthesis inhibitor uses a malt extract as an active component of a synthesis inhibitor of heat-shock protein having 57-68kDa molecular weight. As the malt extract, e.g. directly an article on the market, or preferably an article removed a low molecular weight fraction from the malt extract on the market by a dialysis, etc., can be used. Otherwise, an article obtained by saccharifying the malt, filtering, extracting the resultant residue with water, a hydrophilic solvent or their mixed solution and removing a low molecular weight compound fraction having &lt;=1×10&lt;4&gt; molecular weight may be used.  In this case, the extraction is performed under an alkaline condition, a precipitated substance is removed by neutralizing the resultant extract solution and a low molecular weight fraction is removed from the supernatant, then the resultant substance is more preferably used.
Currently used devices for manipulation with poultry in large-scale breeding facilities require altogether significant amount of hand manipulation with working boards or carriers for access to higher floors of breeding cages even with further equipment. The device according to this invention removes these disadvantages. Its principle consists in manipulation mechanism composed of travelling trolley with working board and travelling frame lead by pulleys on upper and lower guiding profile. The trolley is equipped with dogs for connection with frame. Therefore it is possible to use frame with trolley or the frame alone. Thanks to the above mentioned the easy accessibility in all the floors with breeding cages is ensured, with concurrent use of fixing appliance or eventually of a discharge plate on the travelling frame.&lt;IMAGE&gt;
PURPOSE:To obtain the subject O/W/O type cosmetic having a specific particle diameter with hardly any dispersion thereof by ultrasonically treating a mixed lipid composed of a phospholipid and a nonionic polyoxyethylenic surfactant at a specific molar ratio in an aqueous solution. CONSTITUTION:This cosmetic comprises O/W/O type mixed lipid vesicles, obtained by ultrasonically treating a mixed lipid composed of a phospholipid and a polyoxyethylenic surfactant at (5/95) to (95/5) molar ratio in an aqueous solution (e.g. distilled water, a phosphoric acid buffer solution or a physiological saline solution), e.g. at the phase transition temperature of the mixed lipid or above and 50-100W ultrasonic output for about 10-30min and having about 100-3000Angstrom  particle diameter and &lt;=10% dispersion thereof. For example, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, soybean phospholipid and egg yolk phospholipid are cited as the phospholipid. For example, polyoxyethylene sorbitan esters of fatty acids are cited as the nonionic polyoxyethylenic surfactant. The cosmetic can be prepared as dosage forms such as lotions, milky lotions, creams and ointments.
The present invention relates to a medicine &#39;Yiganjiangmeisan&#39; for treating hepatitis B and a preparation method thereof, which is a pure traditional Chinese medicine preparation mainly used for treating hepatitis B, transaminase raising and icteric index raising. In the prescription, artemisiae scopariae, rhubarb, giant knotweed, scutellaria root and forsythia fruit have the functions of liver protection, transaminase reduction, negative turning promotion, body immunity strengthening, effective hepatitis B resistance, virus prevention, etc.; white peony root, red peony root, rehmannia root, schisandra fruit and ophiopogon root have the functions of blood nourishing, blood stasis dissipation, liver kneading, yin nourishing, fluid promotion, etc.; glossy privet fruit, fleece-flower root and herba ecliptae have the functions of peripheral white cell raising and organism virus-resistant capability strengthening; atractylodes rhizome, aucklandia root, medicated leaven, fructus, calamus and glycyrrhiza have the functions of spleen reinforcing, spleen and stomach strengthening, digestion aid, chest stuffiness relieving, appetite promotion, qi regulation, etc.; kudzu root has the functions of muscles relieving, heat removing, etc.; dahurian angelica root and water plantain have the functions of wind expelling, pain alleviation and abdominal distention elimination; curcuma root and safflower have strong functions of promoting the circulation of qi, removing blood stasis, removing toxicity, improving body immunity, lowering transaminase and promoting negative turning. The clinical application of Dongrong hospital of Shuangyashan city mining group company in Heilongjiang proves that the curative effect is obvious.
A blockchain-based travel security system is provided. The system increases travel security. The system includes an electronically stored user&#39;s itinerary file with a user&#39;s pre-registered travel itinerary. The itinerary file can be stored on a blockchain. The system also includes an electronically stored user&#39;s medical history file stored on the blockchain. A single trusted information source provides the itinerary file and the medical history file to the blockchain. The system includes a dual track information storage and retrieval system which is configured to store the itinerary file and to store the recent medical history file. The dual track information storage and retrieval system comprises a first track related to the user&#39;s recent medical history file and a second track related to the itinerary file.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain an ameliorant for blood fluidity, which has high safety, is readily produced, usable as a food and beverage such as a health food, a health function food (food for specific health care or nutrient function food), a medicine, a quasi medicine, a cosmetic, or the like, and a composition containing the same.  &lt;P&gt;SOLUTION: The ameliorant for blood fluidity comprises a hydrophobic extract of licorice. The medicine or the food composition comprises the ameliorant for blood fluidity. A soft capsule is obtained by sealing the ameliorant for blood fluidity comprising the hydrophobic extract of licorice. The method for ameliorating human or mammalian blood fluidity comprises using the medicine, the food composition or the soft capsule composed of the ameliorant for blood fluidity containing the hydrophobic extract of licorice.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To improve an irritated skin and produce a skin whitening effect by utilizing an extract of star fruit effective for improving an irritated skin, freckles or the like, skin whitening and the like and to remove tea incrustation left on dishes and stains on clothes by utilizing the stain removing action of star fruit.  &lt;P&gt;SOLUTION: A cosmetic soap is made by blending a star fruit extract into a soap base. A skin lotion of star fruit is made by blending 25% star fruit extract, based on the total mass of the skin lotion. The effect of improving an irritated skin, freckles, a somber shade part of the skin color and the like can be produced by using the cosmetic soap and the skin lotion and gloss and tension can be imparted to the skin. A laundry soap is made by blending a star fruit extract into a soap base composed mainly of waste oil. Even tea incrustation and greasy/oily stains left on dishes, which would be difficult to be removed, can be completely removed by washing the dishes with use of the soap and gloss is imparted to the dishes. By using the soap for washing the laundry, stains such as a soy sauce, Worcester sauce and the like, which would be difficult to be removed, can be completely removed and the washed laundry is made softer to the touch.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To obtain a new compound useful as a medicine, a functional food, etc., having inhibitory activity against histidine decarboxylase. SOLUTION: This isoflavon derivative is shown by the formula (R is H or OH). The compound, for example, is obtained by culturing a fungus such as a strain belonging to the genus Aspergillus (e.g. Aspergillus oryzae IFO4206) in a medium and collecting the compound from the culture product. The objective histidine decarboxylase inhibitor participating in biosynthesis of histamine to cause inflammatory diseases such as tumor and allergic diseases comprises the compound of the formula as an active ingredient. A dose of the compound of the formula is 0.01-20g as an active ingredient per adult daily and can be properly mixed with another medicine, etc., and used.  When the compound of the formula is used as a functional food, the compound of the formula added is &gt;=0.01g, preferably 0.5-10g per kg of a food and is applicable to seasonings, marine product foods, processed foods of animal meat, liquors, beverages, cakes, cans, foods of daily dishes, etc.
1485268 Plant extracts S.E.R.T.O.G. SOC D&#39;ETUDES DE RECHERCHES DE TRAVAUX D&#39;ORGANISATION ET DE GESTION 4 June 1975 [4 June 1974] 24640/74 Heading ASB A pharmaceutical composition, with antiinflammatory, hormonal and muscular reactivation properties, contains as its active constituent an extract of a plant with an organic solvent, of the Meliaceae family of the genus Khaya selected from Khaya grandifolia, ivorensis or senegalensis. The extract is prepared by pre-drying and finely grinding the plant and extracting with an organic solvent selected from vegetable oils, e.g. palm or ground nut oil, hydrocarbons e.g. hexane chlorinated hydrocarbons e.g. chloroform or methylene chloride, ethers, alcohols or mixtures thereof.
Provided is a gene expression control method that employs a transcription termination sequence positioned within an intron. The transcription termination sequence is disruptable by the addition of a trans-acting factor. For example, in a &#39;dual splicing switch&#39;, the transcription termination sequence is flanked by recombination sites and can be excised by a recombinase. The Cre/LoxP recombination system may be used for this purpose. In use, the intron containing the disruptable transcription termination sequence is positioned within a reading frame of a target gene. Also provided is a nucleic acid containing this transcription control mechanism and a cell line harboring a gene containing the nucleic acid. In one example, the transcription control mechanism is used to produce a cell line containing a toxic gene, the AAV Rep gene. A cell line for producing recombinant AAV virus particles, or recombinant parvovirus particles, also is provided along with a method for producing the same.
PURPOSE:A toilet lotion composition, containing gibberellin and if necessary a proteolytic enzyme, and capable of dulling the hue caused by pigments deposited by the hyperfunction of melanoside of liver-spot or ephelis on the skin, e.g. the face. CONSTITUTION:A toilet lotion composition, containing gibberellin A1 of formula I , gibberellin A2 of formula II, gibberellin A3 of formula III, gibberellin A3&#39; of formula IV, gibberellin A4 of formula V, etc. produced by Gibberella fujikuroi Sawada of rice plants, and used for eliminating seeds or thickening berries of grapes or increasing the yield and quality of crops, e.g. thickening of fruits of cucumbers, as a plant growth regulating agent, etc. in an amount of 0.001- 5.0wt% in a toilet lotion composition or if necessary 0.001-3.0wt% proteolytic enzyme, e.g. papain produced from juice of a papaya, capable of dulling the hue of pigments deposited on the skin, and usable for all types of toilet lotions.
PURPOSE:To separate albumin from a solution containing blood plasma protein, by using a porous regenerated cellulose membrane. CONSTITUTION:An acidic organic solution, e.g. hydrochloric acid or trichloroacetic acid, etc., and an organic solvent, etc., is added to a solution containing blood plasma protein to form a compound of the blood plasma protein other than albumin with the acid, which is then filtered through a porous regenerated cellulose membrane having 0.02-0.2mum average pore diameter, &gt;=10% porosity and pore diameter distribution with &lt;=1.3 ratio of the fourth average pore diameter to the third average pore diameter to remove the compound of the blood plasma other than the albumin with the acid. The resultant filtrate is then neutralized to separate and recover the aimed albumin as precipitates. EFFECT:The resultant albumin exhibits the same properties as those of the original albumin and is applicable to separation of the albumin in the blood plasma pharmaceutical field, etc. Microbial particles fear to have been mixed in the blood plasma are removed from the recovered albumin.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a composition which protects a living organism from an outside factor.  &lt;P&gt;SOLUTION: This composition protects the living organism from the outside factor, and contains a hot-water extract of Agaricus blazei Murll. The composition protects the living organism by making a cell in charge of an immunization as a mediator. The cell in charge of the immunization preferably comprises a microphage, a T-cell or an antibody-generating cell. The composition protects the living organism by strengthing the humoral immunity. The humoral immunity is strengthing by activating a lymphocyte cell which is selected from a group comprising the activated T-cell and the macrophage, or by strengthing expression of an interleukin which is selected from a group comprising interleukin-1β and interleukin-6. The outside factor is ingested by smoking, or comprises an antigenic substance.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
The invention relates to a novel cosmetic product with special flexibility and stretching characteristics, so-called &#34;stretch-mascara&#34;. The mascara has an oil phase and an aqueous phase, said oil phase containing 2 to 10 wt. % of an unbranched polyethylene wax with a molecular weight of 400 to 1500 Dalton, in relation to the weight of the oil phase, and at least one other wax or oil or mixture thereof. The aqueous phase contains 0.5 to 5 % of a film former PVP/PVP-VA, polyquaternium-46 and mixtures thereof. The product also contains 0.5 to 20 wt. % of an external film former phase with a water-soluble film former selected from the group PEG/PPG-25/25 dimethicone/acrylates/t-butyl acrylates copolymer, polyurethane-1 and mixtures thereof.
Encapsulated or embedded medicaments are produced by (a) dissolving a hydrophobic wall matl. (pref. a non-toxic synthetic high-mol. polymer) in &gt;=1 water-immiscible org. solvent having a b.pt. is not &gt;100 degrees C, a vapour pressure greater than that of water and a dielectric constant is not &gt;10, (b) dissolving or dispersing in the resulting soln. a medicament which is water-insol. or has a low solubility in water, (c) dispersing the resulting soln. or dispersion in a carrier (pref. an aq. hydrophilic colloid and/or an aq. anionic surfactant) so as to form fine droplets, and (d) evapg. the org. solvent. The process gives microcapsules under mild conditions so that the medicament is not decomposed. The microcapsules give excellent masking of unpleasant flavours and odours and improve the stability of the medicament. The microcapsules are so fine that they can be treated as dust-fine powders, and individual microcapsules contain practically identical amts. of medicament, making them partic. suitable for medicinal use.
1,247,804. Antiseptic detergent composition. ETABS. CLIN-BYLA. 13 June, 1969 [28 June, 1968; 5 July, 1968], No. 30181/69. Headings A5B and A5E. [Also in Division C5] An antiseptic detergent composition comprises a stock solution of 3, 4, 4&#39;-trichlorocarbanilide which contains dodecylbetaine or oxy-ethylenated castor oil, as solubilising agent for the 3, 4, 4&#39;-trichlorocarbanilide, the solution remaining clear on subsequent aqueous dilution. The stock solution should preferably contain substantially 5% by weight, more preferably 0.5-5% by weight, 3, 4, 4&#39;-trichlorocarbanilide and may be prepared by adding to an aqueous solution of dodecylbetaine or oxy-ethylenated castor oil, sufficient 3, 4, 4&#39;-trichlorocarbanilide to saturate the aqueous solution and thereafter boiling the solution under reflux for more than 1 hour. These compositions are advantageously used as liquid soaps for disinfection and cleansing which may be diluted with water and further contain essential oils and anionic, cationic and non-ionic detergents. In addition the stock solution may be associated with various ingredients to constitute cosmetological and hygienic products. Examples based on a stock solution containing dodecylbetains describe deodorizing soap cakes which contain as the basic surface active ingredients soap, protein soap or sodium laurylsulphate and in addition polyethyleneglycol, perfume, stearic acid and starch; an after-shave lotion containing menthol, glycerine, perfume and ethyl alcohol; a massage lotion containing glycerine or sorbitol, perfume and ethyl alcohol; a liquid deodorizing and antiseptic soap containing aqueous dodecylbetaine, protein soap and perfume; an antiseptic cream shampoo containing aqueous dodecylbetaine, sodium laurylsulphate, protein soap, lauric acid diethanolamide, carboxymethylcellulose and perfume; a liquid antiseptic shampoo containing E.D.T.A. (sodium salt), aqueous dodecylbetaine and perfume; an antiseptic talc containing titanium dioxide and talc; an antiseptic and deodorizing gel containing ethylhydroxyethyl cellulose and perfume; an antiseptic and deodorizing alcohol bomb containing castor oil, perfume, ethyl alcohol and propellent gas; and an antiseptic and deodorizing cream containing perfume and polyethylene glycol ointment. Similar formulations may be obtained from stock solutions based on oxy-ethylenated castor oil and additionally containing E.D.T.A. (sodium salt), a triethanolamine salt of a condensation product of a fatty coconut acid with a polypeptide and amino acid complex and either lauric acid diethanolamide or sodium laurylsulphate.
The prepn. of coronary active 1, 4-dihydro-pyridines (I) in sorbed form contg. polyacrylate powder comprises dissolving or dispersing polyacrylate in a soln. of (I) in an organic solvent which is miscible with water and adding so much water that (I) is at least partially pptd. out on and/or in the dispersed polyacrylate particles or in the polyacrylate particles which form in the solvent/water mixt.; so that the resulting pseudo latex can be converted into a dry powder by sepn. of the liq. phase. USE/ADVANTAGE - Coronary active (I), such as Nifedipin (1, 4-dihydro-2, 6- dimethyl-4-(2&#39;-niphophenyl-3, 5-pyridine dicarboxylic acid dimethyl ester) can be used to treat disorders of the heart and circulation and to treat hypertonia. The (I) fixed on polyacrylate particles according to the invention are of high bioavailability with an excellent initial steep increase in plasma concn., with an initial peak lower than that given by conventional formulations but a level after 24 hrs which is markedly higher.
PROBLEM TO BE SOLVED: To prepare a cosmetic having excellent applicability and safety, free from blotting in application and useful as a lipstick, etc. SOLUTION: The objective cosmetic is produced by using a fluid oil component (e.g. liquid paraffin) and a solid oil component (e.g. ceresin wax) and adjusting the I.O.B (inorganic value/organic value) difference between the fluid oil component and the solid oil component to preferably &lt;=0.10 and the hardness of the mixture of both oil components to &gt;=12. The solid oil component preferably has an I.O.B of 0-0.15. The cosmetic preferably contains a powder (e.g. talc).
A protective varnish is provided for prophylactic treatment of exposed dentin.  The varnish offers mechanical protection from wear and prevents hypersensitivity by blocking the dentin tubules. The varnish comprises a matrix of curable resins. These resins penetrate the dentin and after curing enforce it, making the dentin more resistant to abrasion. The varnish may also offer an antimicrobial effect. This effect can be achieved by the varnish containing a broad spectrum antimicrobial agent such as 2,4,4&#39;-trichloro-2&#39;-hydroxydiphenyl ether.