anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PURPOSE: A pharmaceutical composition and health functional food containing crude drug extract is provided to prevent and treat neurodegenerative diseases. CONSTITUTION: A pharmaceutical composition for preventing and treating neurodegenerative diseases contains mixture crude drug extract containing Dioscorea Rhizoma and Dioscorea nipponica as an active ingredient, and pharmaceutically acceptable carriers. The neurodegenerative diseases include Alzheimer&#39;s disease, Creutzfeldt-Jakob disease, Huntington&#39;s disease, multiple sclerosis, guillain-Barre syndrome, or Parkinson&#39;s disease. A health functional food composition for preventing and treating neurodegenerative diseases contains the crude drug extract. The crude drug extract is prepared in the form of powder, granules, tablets, capsules, syrups, or drinks. [Reference numerals] (AA) Control group; (BB) Dioscorea Rhizoma/Dioscorea nipponica=3.5:1 mixed extract
A system and method for planning and performing an interventional procedure based on the spatial relationships between identified points. The system includes a storage device ( 102 ) having an image ( 104 ) which includes a plurality of targets ( 107 ). A spatial determination device ( 114 ) is configured to determine distances and/or orientation between each of the targets. The system is configured to compare the distances and generate a warning signal if at least one of the distances is less than a minimum threshold ( 128 ). An image generation device ( 116 ) is configured to generate a graphical representation for display to the user which shows the spatial information between a selected target with respect to the other targets. A planning device ( 126 ) is configured to modify or consolidate targets automatically or based on a user&#39;s input in order to more effectively plan or execute an interventional procedure.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a soap bar which contains a microorganismic culture having no alkali resistance and is capable of preventing the microorganismic culture from deadening in the soap bar, furthermore capable of securely exerting the operation the microorganismic culture has, and to provide a method of delivery using the same.  &lt;P&gt;SOLUTION: This soap bar has the microorganismic culture having no alkali resistance, a gelatin layer covering the microorganismic culture, and a soap body circumscribing the gelatin layer. The microorganism preferably contains at least lactic acid bacteria. Preferably, a layer material in which the microorganismic culture is laminated between a pair of gelatin layers may be arranged so as to divide the soap body into at least two pieces. By this method for delivery utilizing the soap bar, that is a method for delivering a microorganism onto the surface of the person, the microorganism is delivered in an active condition onto the surface of the person.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To enable anyone to easily and promptly record an electronic medical chart.  &lt;P&gt;SOLUTION: A pen type input device (e.g. a liquid crystal pen tablet) is adopted to a hospital computer in creation of the electronic medical chart. Templates for sketching various affected areas are preregistered in the hospital computer. A doctor touches entered affected area figure display areas 27a, 27b of an affected area figure sheet 27 twice with a pen in the case of sketching the affected area figure and sketches the affected areas with a liquid crystal pen using the entered affected area figure or the forms for sketching as design. The doctor performs DO input by displaying a DO input sheet 100 by touching a desired display column of a medical examination act sheet 25 twice with the pen, or touching a DO input button 13 with the pen and touching check boxes of the medical examination act developed in the DO input sheet with the pen in performing the DO input.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
A composition for inducing and stimulating hair growth and/or reducing hair loss comprises at least one alkylpolyglycoside and at least one compound having formula (I) in a physiologically acceptable medium.    &lt;IMAGE&gt;  (I)  In compound (I) , R1 represents the group   &lt;IMAGE&gt;   where in R3 and R4 may be selected from hydrogen, alkyl, alkenyl or cycloalkyl. R3 and R4 may also form a heterocycle with the nitrogen atom to which they are bonded. The heterocycle may be an aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, hexahydroazepinyl, heptamethyleneimine, octamethyleneimine, morpholine or 4-low alkylpiperazidinyl group. These heterocycles may be substituted at the carbon atoms by one to three alkyl, hydroxy or alkoxy groups. R2 is selected from hydrogen, alkyl, alkenyl, alkylalkoxy, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl and/or haloarylalkyl. The physiologically acceptable acid addition salts of the compound may also be used.
Nucleic acid delivery vehicles and methods of their use are provided. One embodiment provides a virus having a lipid-polymer conjugate intercalated into the virus&#39;s membrane. The lipid-polymer conjugate includes a biocompatible polymer having first and second ends, a lipid conjugated to the first end, and a targeting moiety conjugated to the second end. The lipid is preferably a multi-chain lipid. The virus encodes one or more polypeptides that can help reduce or mitigate one or more symptoms of a disease or pathology. The lipid-polymer conjugate advantageously reduces non-specific binding of the virus while the targeting moiety enhances binding to specific cells or tissues.
The invention belongs to the technical field of pharmaceutical chemistry, and discloses an amide aromatic phenol antibacterial peptide mimic with anti-drug-resistant bacteria activity and no obvious toxicity and a preparation method thereof. The invention obtains the target product through 3-4 steps of reaction, and the main structure is shown as follows. In-vitro antibacterial activity experiments prove that most of compounds in the series have good activity on gram-positive bacteria staphylococcus aureus, enterococcus faecalis, gram-negative bacteria escherichia coli and stenotrophomonas maltophilia, and the compounds have excellent broad-spectrum antibacterial activity; meanwhile, in vitro erythrocyte hemolytic data show that the medicine has low toxicity and good selectivity. Some compounds also show excellent antibacterial activity against &#34;superbacteria&#34; including methicillin-resistant staphylococcus aureus (MRSA), clinical strains producing NDM-1 and KPC-2 enzymes, and the like. Therefore, the series of compounds are expected to be used as new antibacterial candidate drugs. 。
IN THE    CANADIAN           PATENT &amp; TRADEMARK OFFICE PATENT APPLICATION   entitled: Derivatives of 3-imino-pyridazine, process for obtaining them and pharmaceutical composi-tions containing them in the names of: Camille Georges WERMUTH, Gilbert SCHLEWER, Michel HEAULME   assigned to: SANOFI               ABSTRACT OF THE DISCLOSURE      The invention relates to derivatives of 2,3-dihydro 3-imino-pyridazine responding to general formula:     (I)   in which: - A represerts an atom of oxygen or of sulfur; - R1 represents a lower alkyl group, or an aromatic group selected from:      . the phenyl group; . the phenyl groups mono- or poly-substituted by a halogen group, a lower alkyl group, a lower alkoxy group, a nitro group, a hydroxy or methylene-dioxy group;      . the naphthyl group; . the furyl group; . the thienyl group or the pyridyl group; - R2 and R3 each designate independently hydrogen or a lower alkyl group; a phenyl group, or R2 and R3, taken together, constitute, with the 2 atoms of the pyridazinic cycle to which they are bonded, a benzene ring, and their pharmaceutically acceptable salts. Application: antidepressants or psychotonics.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a tool useful for developing a medicine that regulates immunoreaction through action or activity of Th1 cell-specific Txk or useful for diagnosing or treating immunological diseases and an application thereof.  &lt;P&gt;SOLUTION: The protein complex comprises at least two kinds of proteins selected from the group consisting of Txk, EF-1α and PARP-1. The index agent for regulation of immunoreaction comprises the proteins. The screening method for identifying a substance for regulating Th1/Th2 immunoreaction comprises supplying the index agent under a condition that the Txk, EF-1α and PARF-1 form a protein complex and using any process of (1) a process for assaying the degree of formation of the complex in the presence of a test subject, (2) a process of assaying the degree of phosphorylation of the complex in the presence of a test subject and (3) a process for assaying ability of combination of the complex with Txk RE DNA in the presence of a test subject. The diagnostic detects the complex. The medicine composition treats diseases through regulation of Th1/Th2 immunoreaction. The active ingredients of the medicine composition are used for producing the medicine.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a formulation for the treatment of asthma having desirable solubility, stability, low toxicity, accurate dosage, correct particle size and/or compatibility with a usual valve assembly of a dosage-metering inhaler and not containing CFC (chlorofluorocarbon), and a method for producing the same.  &lt;P&gt;SOLUTION: An aerosolized formulation for the treatment of asthma (which contains mometasone furoate and formoterol fumarate) and the method for preparing the same are disclosed. The invention relates to a process for producing the nontoxic formulation that does not substantially contain CFC and possesses improved stability and compatibility with medicines and is relatively easily produced. The formulation is produced according to an ordinary procedure in the art for other aerosol compositions. Typically, all components other than this atomizing agent are mixed and introduced in an aerosol can.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
A computational personalized cognitive therapeutic system for treating patients with Mild Cognitive Impairment, Alzheimer&#39;s Disease, dementia and related conditions is described. The system includes a patient clinical database, a data aggregation layer and data pre-processor module, a digital cognitive therapy delivery module, a cognitive analytics engine, and a personalised cognitive platform configured to personalize a personalised cognitive digital therapy model. The personalised cognitive digital therapy model defines specific digital treatments to be delivered to the patient using the digital cognitive therapy delivery module each with a different mechanism of action. A range of digital cognitive biomarkers are collected along with behavioural and physiological biomarkers from wearable and medical devices which are processed by the cognitive analytics engine and uses AI/ML methods which are configured to estimate metrics and generate alerts. The metrics are used to assess treatment progress and then personalize the personalised cognitive digital therapy model for the patient including adjustment of digital therapies and medication. Alerts may be generated if adverse side effects are observed. This process is iteratively repeated to provide improved treatment over time.
The present invention relates to a capsule preparation for treating skin rubella. Urticaria belong to hidden rash and wheals in traditional Chinese medicine. Rubella has characteristics of spot-like wheal on skin. Ephedra diaphoresis has effects of inducing sweat, dispelling exogenous evils,ventilating lung, relieving asthma, inducing diuresis to alleviate edema, warming channel to dredge skin, and relieving red spot toxin, and mainly cures a case of a physically strong patient running a high fever caused by cold, rubella and pruritus. A main symptom of urticaria is pruritus; the cause of urticaria is that wind evil in blood and viscera causes ying-wei disorders; and urticaria shows syndrome of complex in deficiency and excess in clinic. Codonopsis pilosula, licorice and Astragalus mongholicus can tonify qi, and ginger with hot nature can strengthen channel warm, restore Yang and consolidate superficies; the formula comprises smoked plum with acidity and astringency, and cinnamon, asarum and white paeony root capable of astringing Yin and regulating ying, and ephedra with hot nature and divergence; astringency and divergence adjust the ying-wei, dispel wind and cold, eliminate rash and itching, so as to cure manifestation cause; and Codonopsis pilosula, licorice and Astragalus mongholicus can tonify qi and consolidate superficies, so as to cure the root cause, according to a principle that &#39;&#39;curing blood before wind, and blood circulation killing the wind&#39;&#39;.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an anti-ulcer composition which is derived from an evening primrose and has high safeness and an excellent anti-ulcer action.  &lt;P&gt;SOLUTION: The anti-ulcer composition contains a solvent extract of an evening primrose. The solvent extract is preferably one of evening primrose seeds; more preferably, one of defatted evening primrose seeds. The solvent extract is preferably a water-containing ethanol extract, more preferably a water-containing ethanol extract with an ethanol concentration of 40-90% (wt/wt). The anti-ulcer composition is used preferably as a material for food and drink or for drugs.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
PCT No. PCT/US94/09172 Sec. 371 Date Feb. 6, 1996 Sec. 102(e) Date Feb. 6, 1996 PCT Filed Aug. 11, 1994 PCT Pub. No. WO95/05201 PCT Pub. Date Feb. 23, 1995An adenovirus wherein the adenovirus fiber protein includes a ligand which is specific for a receptor located on a desired cell type. The adenovirus may have at least a portion of the adenovirus fiber protein removed and replaced with a ligand which is specific for a receptor located on a desired cell type, or the adenovirus may include a fusion protein of the adenovirus fiber protein and the ligand. Such an adenovirus may also include a gene(s) encoding a therapeutic agent(s) and may be &#34;targeted&#34; in order to deliver such gene(s) to a desired cell type.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain an effect to promote recovery of a hairless scalp by enhancing an effect of blood circulation.  &lt;P&gt;SOLUTION: Two kg of Aloe arborescens is washed with water, is dried in the sun for one day, and is put in a vessel. 1.8 L of white liquor (35% alcohol) for a fruit wine is poured in the vessel and sealed. The vessel is preserved for 6 months. A solution synthesized and extracted in the vessel is all of contained components.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
The oral administration and external application of the ginseng, poria, fragrant and wood toxin expelling soup has very poor curative effect on allergy caused by penicillin treatment of venereal disease viruses in gynecological clinical treatment, the problem of treating viruses is urgently needed to be solved by taking the answer in the traditional Chinese medicine, and the &#39;scouring rush&#39; is found by screening in the &#39;traditional Chinese medicine Daquan&#39;, the &#39;herbal compendium&#39; and the &#39;medical religious gold discriminator&#39;, i have treated my eye diseases with the &#39;scouring rush&#39; and the symptoms of redness and itching and are rubbed by me. The scouring and washing of the scouring liquor with the scouring liquor of the scouring rush herb are finished. Because of the red swelling, itching and erosion phenomena during the treatment of venereal disease virus infection, the characteristics of treating red swelling, itching and restoring erosion of the horsetail are utilized, and the following steps are added: (1) purple ginseng herba scutellariae barbatae: can resist virus, tumor and cancer. (2) And (3) rhizoma cyperi: it can regulate qi, regulate blood and enter triple energizer. (3) Rhizoma smilacis glabrae: removing heat and toxic materials, and resisting tumor. (4) Honeysuckle flower: clearing heat and diminishing inflammation, eliminating tumor and resolving sore. The Chinese medicine with the functions of promoting blood production, nourishing blood, nourishing yin and tonifying liver and kidney is added to form the effective prescription for curing venereal disease virus, and the treatment scheme of the oral administration and external application of the ginseng, poria, fragrant wood and toxin expelling soup is provided.
PROBLEM TO BE SOLVED: To obtain a low caloric food material containing starch, a gelling agent, a clouding agent, a specific agent for controlling intestinal function and water at specific ratios, having low caloric value, similar to cooked rice in appearance and texture and exhibiting excellent intestinal function controlling effect. SOLUTION: This food material contains (A) 1-35wt.% of starch (preferably modified starch such as crosslinked starch), (B) 0.1-7wt.% of a gelling agent, (C) 1-20wt.% of a clouding agent (preferably e.g. a powdery cellulose having an average polymerization degree of 100-300 and passing through a 60 mesh sieve), (D) 0.1-10wt.% of an intestinal function controlling agent selected from oligosaccharides and dietary fibers and (E) the remaining part of water. The component B is preferably a combination of refined powder of KONJAK (paste made from the starch of devil&#39;s-tongue) or KONJAK mannan with other gelling agent. The oligosaccharide of the component D is preferably lactosucrose and the dietary fiber is preferably a polydextrose.  The objective material is produced preferably by kneading the above components, extruding the obtained dough with an extruder, cutting the extrudate and gelling the obtained pellets.
The present disclosure relates to an immunologically active peptide-biliverdin conjugate (I), a preparation method therefor and an application thereof in cancer diagnosis, and/or tumor immunotherapy, and/or tumor &#34;photothermal immunotherapy&#34; (tumor photothermal therapy combined with immunotherapy). The conjugate to which the present disclosure relates not only may stimulate an organism to generate a tumor-immune effect, but also may relieve and/or eliminate tumor inflammation, remodel a tumor inflammatory microenvironment and achieve photothermal cancer immunodiagnosis and immunotherapy. The conjugate to which the present disclosure relates has high biocompatibility, good stability and an extended half-life. The conjugate is prepared from an immunologically active peptide and biliverdin by means of chemical synthesis. A peptide end of the conjugate exercises the function of immunoregulation, and a pigment end thereof exercises functions such as tumor imaging diagnosis, tumor photo-thermal ablation, immune inflammatory microenvironment regulation and the like. The conjugate may significantly enhance the anti-tumor effect and effectively inhibit tumor metastasis and recurrence.
An antibiotic, (l) - #Y - 1 - p - nitrophenyl - 2 - dichloroacetamidopropane-1 : 3-diol, is obtained by cultivating Streptomyces venezuelae in contact with a nutrient medium under aerobic conditions (i.e. on the surface of the medium, e.g. for 10-15 days at 25 DEG  C., or in the submerged condition with aeration and agitation, e.g. for 2-7 days at 25 DEG  C.).  The nutrient medium is preferably an aqueous medium containing an assimilable carbon source (a polyhydric alcohol or a mono-, di- or poly-saccharide, e.g. glucose, fructose, sucrose, inulin, dextrins, starches and especially sugar alcohols such as sorbitol and particularly glycerol) and a proteinaceous material (unmodified protein or protein degradation products such as proteoses, peptones, polypeptides, peptides and amino acids).  The carbon source or the proteinaceous material or both together may also be provided by various complex products, e.g. liquefied or modified starches, molasses, corn syrup; acid or enzyme hydrolysed casein, distillers&#39; grain slops, distillers&#39; solubles, soybean meal, acid hydrolysed corn or wheat gluten, peptone, brewers&#39; yeast, offals, synthetic mixtures of amino acids; whey concentrates, grain p  mashes, corn and wheat steep liquor.  The antibiotic may be isolated from the culture medium by the following series of steps: (a) clarifying the liquid below about pH 10; (b) extracting the solution with an organic solvent having a solvent-water distribution coefficient for the antibiotic above about 9 (e.g. cyclohexanone, butanol, ethyl acetate or methyl isobutyl ketone); (c) removing the solvent from the extract; (d) extracting the residue with an organic solvent having a distribution coefficient between about 1 and 9 (e.g. nitrobenzene, nitromethane, diethyl ether or ethylene dichloride); (e) washing the extract with dilute mineral acid and water (and preferably also with dilute alkali); (f) adding water to the organic solvent extract; (g) evaporating the organic solvent from the mixture; (h) extracting the aqueous solution with an organic fat solvent in which the antibiotic is substantially insoluble (e.g. benzene or petroleum ether); (i) evaporating the aqueous solution to the point of crystallization. Alternatively, steps (b) and (c) may be omitted, the clarified solution being directly extracted with the type of solvent used in (d).  Again, when the solvent used in (d) is a lower dialkyl ether, the washing step (e) may be replaced by passage of the solution over an aluminium oxide type adsorption column.  A further alternative consists in adsorbing the antibiotic from the clarified culture liquid on to activated charcoal, eluting it with ether or 80 per cent acetone, adding water, distilling of the organic solvent, removing any gummy material which separates and concentrating the aqueous solution to the point of crystallization. Examples illustrate various features of the invention.
PROBLEM TO BE SOLVED: To obtain the subject inhibitor having excellent α-glucosidase inhibiting activities useful for treatment of metastatis of cancer, virus disease, diabetes mellitus, etc., by including a pyrazolone-based compound or its salt having a specific structure. SOLUTION: This inhibitor includes a pyrazolone-based compound of formula I (R&lt;1&gt; is an alkyl, phenyl, etc.; R&lt;2&gt; is H, a halogen, etc.) or its salt. The compound of formula I in which R&lt;2&gt; is a group of phenylcarbonylamino or R&lt;1&gt; is a group of alkylcarbonyloxyalkyl is the new one. 4,4-Dibromo-3-benzoylamino-1-phenyl-2- pyrazolin-5-one is preferable as the former and 4,4-dibromo-1-(2-acetoxyethyl)-3- methyl-2-pyrazolin-5-one is preferable as the latter. The compound of formula I is, for example, obtained by reacting a compound of formula II with a brominating agent such as bromine at 5-100 deg.C for 0.5-24hr. The daily dose of the compound of formula I is usually 50-5,000mg for an adult.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method and product for characterizing and using polysaccharide.  &lt;P&gt;SOLUTION: There are provided a method and product for characterizing and using polysaccharide. Low molecular weight heparin product and method of use are described. The method for characterizing purity and activity of polysaccharid preparations including glycosaminoglycans such as heparin are also described. The method is for analyzing includes: (A) a step of generation the decorated polysaccharide applying an experimental restriction to the polysaccharide in a sample and having signature component; (B) a step of detecting existence of the signature component in the sample as an index showing that the polysaccharide exists in the sample; and (C) a step of determining the existence or nonexistence of the signature component and analyzing the sample.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT