anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a composition which is excellent in hypoglycemic action and solves the problem associated with a composition containing three active ingredients wherein the degree of contribution of the each active ingredient to the total physiological activity of the composition was unclear.  &lt;P&gt;SOLUTION: This composition contains Ganoderma lucidum and a root of Panax japonivus as active ingredients. Each of the active ingredients can comprise a hot-water extract and/or an extract of a water-alcohol mixture. The composition contains 15-20 pts.wt. root of Panax japonivus based on 100 pts.wt. Ganoderma lucidum.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
PURPOSE:To obtain a new type hair dye consisting essentially of an acid dye used in a semipermanent hair color, further a high-molecular weight silicone, a dissolvent therefor and a polyoxyalkylene type surfactant without any problems. CONSTITUTION:This hair dye consists essentially of an acid dye used in a semipermanent hair color (e.g. an azo-based, a triphenylmethane-based or a nitro-based acid dye), further a high-molecular weight silicone compound (a compound having 100000-4000000 molecular weight and polysiloxane bond as a main chain), a dissolvent therefor (e.g. an isoparaffinic hydrocarbon or a low-molecular weight silicone compound) and a polyoxyalkylene type surfactant (e.g. a surfactant having a polyoxyalkylene chain in the molecule and &gt;=4 HLB). The hair dye is improved in dyeability and excellent in touch after dyeing the hair and hardly falls off even by washing without any damage to the hair or contact dermatitis. The hair dyeing step is short and buildup properties are good. Furthermore, the resistance to shampoos or fastness to water is improved.
The present disclosure relates to aggregating and sharing health data. The wellness data may be received by the user device from any number of sensors external or internal to the user device, manually entered wellness data from the user, or from other users or entities. The user device may securely store the health data on the user device and transmit the health data stored on the remote database. A user of the device may share some or all of the health data with friends, relatives, caregivers, healthcare providers, and the like. The user device may also display the health data of the user in an aggregated view of different types of health data. In the event that authorization is received from other users, the other users&#39; health data may also be viewed.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide biological reagents and conjugates that can be used to detect and isolate target components from complex mixtures such as nucleic acids from biological samples, cells from bodily fluids, and nascent proteins from translation reactions.  &lt;P&gt;SOLUTION: Biological reagents comprise a detectable moiety bound to a photoreactive moiety. Conjugates comprise biological reagents coupled to substrates by covalent bounds which can be selectively cleaved with the administration of electromagnetic radiation. Targets substances labeled with detectable molecules can be easily identified and separated from a heterologous mixture of substances. Exposure of the conjugate to radiation releases the target in a functional form and completely unaltered. Using photocleavable molecular precursors as the conjugates, label can be incorporated into macromolecules, the nascent macromolecules isolated and the label completely removed.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
PURPOSE:To obtain a solvent-based nail enamel improved in gloss and retaining property with lapse of time by combining a specific silicone resin with nitrocellulose or high-volatile solvent or the both. CONSTITUTION:The aimed nail enamel contains a silicone resin [e.g. resin in which R is a mixture of phenyl group and methyl group having a molar ratio of phenyl group to methyl group of 2.5 and a is 1 or 2 and molecular weight is about 3000) having average composition formula expressed by the formula (R is (un)substituted monovalent hydrocarbon and (a) is integer of &gt;=0.8 and &lt;=1.8) and 11-25wt.% nitrocellulose or contains 25-50wt.% silicone resin and high volatile solvent (e.g. toluene, xylene, ethyl acetate, etc.) or contains silicone resin and 11-25wt.% nitrocellulose and 25-50wt.% high volatile solvent. The enamel has merits capable of readily applying and having good gloss and retaining property with lapse of time and quick dryness and capable of eliminating pressing feeling of finger tip.
1,177,400. Dobbies. STAUBLI &amp; CO. GEB. 28 Sept., 1967 [7 Oct., 1966], No. 44212/67. Heading D1E. In a dobby as disclosed in Specification 1026389, in which pusher rails 12a, 12b operate baulks 9 carrying hooks 10a, 10b engageable by arrester hooks 18a, 18b, lost motion is provided between the arrester hooks and their tails 17a, 17b which are acted on by the pattern mechanism; the arrester hooks can therefore be positioned in the path of the hooks on the baulk before the pusher rails reach the end of their stroke, the lost motion allowing the hooks to snap into engagement under the action of springs 24a, 24b. As shown, the tails 17a, 17b are operated by pegs on opposite sides of the pattern chain 16. In another arrangement, the tail 17a points vertically downwards and the tail 17b points upwards, so that they are side-by-side and are operated by pegs on the same lag; alternatively, they may be operated by a paper pattern through pusher needles.
The invention discloses a novel silicon-phenanthroline derivative, a method for preparing the compound and application thereof. The compound takes a silicon atom as a core, takes phenanthroline or a derivative thereof and 4,4 &#39;-dinonyl-2, 2&#39; -bipyridyl as a coordination structure, and has the following structure: r is hydrogen, alkyl (methyl, ethyl) or aryl (phenyl, tolyl or ethylphenyl). The structural compound can form stable salt with inorganic acid or organic acid. The preparation method of the silicon-phenanthroline derivative is simple and feasible and is suitable for expanded production. Has antibacterial effect on bacteria such as Staphylococcus aureus and Escherichia coli, and fungi such as Cryptococcus and Candida albicans. The compound can be accepted by pharmacyThe carrier or excipient of (1) is prepared into antibacterial and/or antifungal medicines.
In ornamental plants, artificial polyploidization has enabled the creation of new cultivars. Due to their high commercial value in the international flower market and their ornamental characteristics, such as the shape, size, color, and durability of their flower, orchids have received great attention in studies of artificial polyploidization. Here we described the protocol used for polyploid induction in Oncidium crispum, an epiphyte species native of southeastern Brazil, of great ornamental interest and widely sold in flower shops. The species stands out for having inflorescence with large flowers, brown in color with yellow spots. In addition, O. crispum has great potential for use in genetic improvement programs since the species is widely used in interspecific crosses. Closed capsules containing mature O. crispum seeds were subjected to running sterilized water for 10 min and then to a 1.5% sodium hypochlorite solution for 10 min. Small portions of seeds were introduced into 50 mL of water-soluble fertilizer with macro- and micronutrients (B&GTM) plus 0.7% agar. Explants originating from seeds previously in vitro germinated were submitted to 0.05% and 0.1% of colchicine for 4 days and 8 days. Flow cytometry and chromosome counts confirmed that the protocol successfully produced synthetic polyploid plants.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain an active oxygen scavenger comprising a degraded substance of an anthocyanine pigment and to provide a method for producing the same.  &lt;P&gt;SOLUTION: The active oxygen scavenger comprises the degraded substance of the anthocyanine pigment derived from an acerola as an active ingredient. The method for producing the same is provided. The active oxygen scavenger comprises the degraded substance of the anthocyanine pigment with vitamin C and/or a metal. The method for producing the same is provided.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
1,257,190. Anilino-acetic acids. J. R. GEIGY A.G. 19 Dec., 1968 [20 Dec., 1967 (2)], No. 60497/68. Heading C2C. Compounds of Formula I wherein R 1 is Cl, Br, F, CF 3 , C 1-4 alkyl or C 1-4 alkoxy, R 2 and R 3 are each H, Cl, Br, F or C 1-4 alkyl and R 4 is H, Cl, Br, F; C 1-4 alkyl or C 1-4 alkoxy and at least one of R 1 , R 2 and&#39; R 3 is other than H and is ortho to the NH group, and salts thereof, are&#39; prepared from the isotins of Formula IV either by reduction with hydrazine or semicarbazide and an alkali metal hydroxide or alcoholate according to the Wolff - Kishner method or by hydrolysis to a glyoxylic acid V which is then reduced by the same method and in each case optionally converting thesalt obtained into the free acid or other salts. Compounds of Formula IV above are prepared by cyclization of the compound of Formula III / prepared by reaction of oxalic acid chloride and the corresponding N-arylanaline derivative, some of which are obtained by decarboxylation of the corresponding ortho-carboxylic acids obtained by copper/KOH fusion of an orthochlorobenzoic acid and a substituted analine.
[GB1257190A]
These and other objects of this invention are achieved by providing a novel method and compositions for the clinical treatment of chronic inflammatory diseases. This invention involves use of systemically administered compositions which include primary amine derivatives of benzoic acid as carbonyl trapping agents. These primary therapeutic agents act by chemically binding to and sequestering the aldehyde and/or ketone products of lipid peroxidation. Increased levels of lipid peroxidation have been repeatedly demonstrated as a part of the non-enzymatic &#34;inflammatory cascade&#34; process which underlies the secondary etiology of chronic inflammatory diseases. p-Aminobenzoic acid (or PABA) is an example of the primary therapeutic agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group that reacts with carbonyl-containing metabolites under physiological conditions and is tolerated by the body in relatively high dosages and for extended periods. The carbonyl sequestering agents are used in combination with at least one co-agent so as to produce an additional beneficial physiological effect of an anti-inflammatory nature. Such compositions are administered systemically entirely via the oral route. Co-agents of the present invention include anti-oxidants and free radical trapping compounds (e.g., alpha-tocopherol), compounds having indirect anti-oxidant activity (e.g., selenium), vitamins (e.g., pyridoxine HCl), compounds which facilitate kidney drug elimination (e.g., glycine), metabolites at risk of depletion (e.g., pantothenic acid), sulfhydryl containing chemicals (e.g., methionine), compounds which facilitate glutathione activity (e.g., N-acetylcysteine), and non-absorbable polyamine co-agents (e.g., chitosan).
The present invention relates to medicine. A hardware/software system for rehabilitation of patients with cognitive impairment after upper limb stroke comprises virtual reality gloves, a controller with sensors, an electroencephalograph and a computer provided with a task-specific game. The glove is equipped with built-in sensing elements that track finger and hand movements in space. A controller is located on the shoulder joint to gather information about the motion of the shoulder joint during the performance of an exercise in the game. The computer is configured to receive information from the aforementioned device; performing computer analysis of the received information about the patient&#39;s brain, arm muscles and fine motor skills; determining the degree of fatigue of the patient; automatically adjusting the exercises in the game and selecting the most effective exercise; and storing the patient rehabilitation results in a database. The invention provides more effective rehabilitation for the patient with cognitive impairment after upper limb stroke.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a permanent wave agent decreasing damage of hair and easily usable, and to provide a permanent-waving method.  &lt;P&gt;SOLUTION: The permanent wave agent is used with a second agent containing hydrogen peroxide and a third agent containing a bromate salt as oxidizers. Thereby, as the irritation on the hair due to the oxidizer is moderated than that of hydrogen peroxide single use so the damage caused on the hair is decreased. And, as the treating time can be shortened than that of bromate salt single use, so treatment can be performed without forcing long time endurance to a subject and occurrence of damage caused by hair exposure to chemicals is suppressed. A forth agent composed mainly of a treatment oil agent is preferably used therewith. And, after treatment using the first agent/second agent and the third agent, a fifth agent composed mainly of glyoxylaldehyde and for removing remaining oxidizers and reductants is preferably used.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
PURPOSE:To obtain the objective modified powder giving soft and smooth feeling to the skin and easily removable from the skin with a soap by coating powder particles with a mixture of methylhydrogenpolysiloxane and a silicone compound having one terminal modified with methacrylic group and heat-treating the coated powder particles. CONSTITUTION:The objective powder can be produced by coating powder particles with a mixture of (A) methylhydrogenpolysiloxane, (B) at least one kind of a silicone compound modified at one terminal with methacrylic group, having short chain length and expressed by formula I (a is integer of 15-25; R is organic modifying group containing methacrylic group) and (C) at least one kind of a silicone compound modified at one terminal with methacrylic group, having long chain length and expressed by formula II (a is integer of 30-60) and heating the coated powder particles at 110-200 deg.C for 1-24hr, preferably at 120-150 deg.C for 4-8hr. The amount of the component A is preferably &gt;=10 pts.wt. based on 100 pts.wt. of B+C and the total amount of A, B and C is preferably 2-18 pts.wt., especially 3-12 pts.wt. based on 100 pts.wt. of the powder.
PURPOSE:To efficiently purify the subject substance which is a specific antibody to a high purity by bringing an immunoglobulin-containing sample into contact with an anion exchanger having DEAE groups, developing the adsorbed substances with a buffer solution in a specific common salt concentration and eluting the adsorbed substance with a buffer solution in a higher common salt concentration. CONSTITUTION:A mouse.hybridoma capable of producing a specific antibody (e.g. monoclonal antibody against colic cancer) is transplanted into the abdominal cavity of a mouse. After 10 days, an ascitic fluid containing immunoglobulin is collected. A 100% aqueous solution of saturated ammonium sulfate is then added to centrifuge formed precipitates. The obtained precipitates are subsequently dissolved in a buffer solution, dialyzed, brought into contact with an anion exchanger having diethylaminoethyl(DEAE) groups and then developed with the first buffer solution containing 100-130mM NaCl. The resultant adsorbed substances are then eluted with the second buffer solution containing NaCl in a higher concentration of &lt;=160mM to afford the immunoglobulin purified to a high purity.
The present disclosure relates to computer technology for the accurate diagnosis of genetic material of various states, such as genes sequenced from cell-free DNA in a sample. The state may include a somatic homozygous deletion, a somatic heterozygous deletion, a copy number variation, or other state. The computer system may generate competition probability models, each of which outputs a probability that the genetic material is in a certain state. Each model may be trained on a training set of samples to output probabilities that genetic material is in a respective state. In some embodiments, the computer system may generate a model using various probability distributions. For example, the computer system may use a β -binomial distribution, a normal (also referred to as &#34;gaussian&#34;) distribution, or other types of probabilistic modeling techniques.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for repairing a fiber-reinforced composite structure using a carbon nanotube, a fiber and a thermosetting resin while maintaining original electromagnetic and lightning strike protection.  &lt;P&gt;SOLUTION: The method according to an embodiment of the present invention comprises preparing a damaged area to be repaired, preparing a repair patch made of a nanotube for the damaged area, adhering the repair patch to the damaged area and curing the repair patch, wherein the repair patch is that for a composite structure having a conductive layer. According to the embodiment, the repair patch includes a binder and a nanotube and is a repair resin for repairing a composite structure having a conductive layer. According to the embodiment, the repair layer includes a resin and a nanotube and is a putty for repairing a composite structure having a conductive layer. According to the embodiment, the putty includes a base and a conductive carbon nanotube.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To obtain a lepidocrocite particle excellent in dispersibility, coloring property and covering property by allowing a ferrous sulfate aq. solution to react with an alkali hydroxide aq. solution in the presence of a specific compound to prepare a suspension containing a hydroxide of iron and blowing an oxygen-containing gas into the suspension. SOLUTION: The suspension containing the hydroxide of iron and having pH 7-9 is prepared by mixing the ferrous sulfate aq. solution, the alkali hydroxide aq. solution with 0.1-5.0mol% phosphorus compound, citric acid compound or their mixture at 25-55 deg.C. A lepidocrocite particle is obtained next by blowing the oxygen containing gas into the suspension at 25-55 deg.C while adjusting to pH 7-9 to oxidize the hydroxide of iron. The lepidocrocite particle exhibits a rectangular parallelepiped having 0.045-0.5μm minor axis diameter, 0.05-1.0μm major axis diameter and 0.001-0.3μm thickness and the geometric standard deviation of the major axis diameter is &lt;=1.7.
1330360 Steroid talomethylosides DR KARL THOMAE GmbH 2 Nov 1971 [2 Nov 1970 25 Sept 1971] 50939/71 Heading C2U The invention comprises compounds of formula wherein R 1  and R 2  are each H or C 2-4  alkanoyl, or together represent a -C(A)(B)- group in which A is H or Me and B is Me or Ph, or A, B and the intervening carbon atom together form a 6- or 7-membered cycloaliphatic ring; R 3  is H, C 2-4  alkanoyl or the acyl radical of a heterocyclic carboxylic acid; R 4  is CH 3 , CHO or CH 2 OH; R 5  is a 20(22)-cardenolide or 20, 22-bufadienolide lactone ring; R 6  is H and R 7  is H or OH or R 6  and R 7  together represent an additional 4,5- bond; with the provisos that (i) when R 5  is a cardenolide lactone ring and R 4  is CHO or CH 2 OH, then at least one of R 1 , R 2  and R 3  is other than H; and (ii) when R 5  is a bufadienolide lactone ring, then R 7  is other than H. Compounds I are prepared (a) by reduction of the 4&lt;SP&gt;1&lt;/SP&gt;-oxo group in compounds of Formula II or (b) by reacting a compound of Formula III with a compound of Formula IV wherein R 4 &lt;SP&gt;1&lt;/SP&gt; is CH 3  or CHO, Hal is Cl or Br and Ac is acyl. Method (a) (which may also be used for the preparation of compounds I which violate proviso (i) above) may be effected with a complex metal hydride and may result in partial or complete reduction of any 19-oxo group to hydroxy. Method (b) may be effected in the presence of Ag 2 O, Ag 2 CO 3 , Hg(CN) 2 , pyridine or 2,6-lutidine, and, when the groups Ac are other than as defined for R 1 , R 2  and R 3 , they must be removed. The products of methods (a) and (b) are convertible into other compounds of Formula I by esterification, acetalization, ketalization, hydrolysis of ester, acetal and ketal groups, and reduction of 19-oxo to hydroxy. Compounds II wherein R 1  and R 2  together represent a -C(A)(B)- group as defined above, are prepared by oxidation of the corresponding acetalized or ketalized α-L-rhamnosides. Compounds I are said to be cardioactive, and may be made up with carriers into pharmaceutical compositions for oral, rectal or parenteral administration.
PURPOSE:To obtain a hair rearing agent containing a phthalid derivative as an active ingredient, having excellent hair rearing effect and effective against almost alopecia regardless of difference of disorder and individual difference. CONSTITUTION:The aimed hair rearing agent containing a phthalid derivative expressed by formula I (R&lt;1&gt; is 3-16C straight-chain or branched alkyl or 3-4C straight-chain or branched alkoxy; R&lt;2&gt; is H, hydroxy or methoxy) as an active ingredient. When used, hair nursing medicines ordinarily used, e.g. antiphlogistic agent, cell activating agent and vitamins are as necessary properly blended in addition to the above-mentioned active ingredient. The hair rearing agent is preferably formulated to coating agent such as ointment, lotion or emulsion. Furthermore, every substance of natural substance extracted from Oenanthe plant or synthetic substance obtained by reacting according to the reaction formula may be used as the compound expressed by formula I.
FIELD: medicine. ^ SUBSTANCE: invention belongs to manufacture of highly dispersed powders of organic medicinal substances and can be used for new medicinal forms preparation. Manufacture method of pharmaceutical composition in form of microencapsulated particles of N-carbamoil-methil-4-phenyl-2-pyrrolidon includes following stages. In the neutral gaseous atmosphere are simultaneously evaporated N-carbamoil-methil-4-phenyl-2-pyrrolidon and non-ionic superficially active substance (SAS). Vapors of both components cocondense on deposition surface. During components&#39; cocondensation, condensation rate vectors of N-carbamoil-methil-4-phenyl-2-pyrrolidon and SAS are directed to the centre of deposition surface. The angle between condensation rate vectors of the components and inclination angle of this angle&#39;s bisectrix to deposition surface are 5-170 and 10-90 respectively. Process of microcapsulation can be performed at above zero deposition surface temperature during cocondensation or, in case of deposition surface negative temperature, by heating it up to positive temperature. ^ EFFECT: new method allows to perform one-step manufacture of water-dispersible pharmaceutic composition with narrow range of particles size, not exceeding 1,5 mcm, which, being mixed with water, is able to form fine suspensions and colloidal solutions. ^ 4 cl, 5 dwg, 4 ex
&lt;P&gt;PROBLEM TO BE SOLVED: To provide sodium phlogopite powder scarcely containing impurity, having high cation exchange capability and swelling property and hardly causing elution of fluoride ion.  &lt;P&gt;SOLUTION: The synthetyic sodium phlogopite exhibits 50 meq/100g cation exchange capacity (CEC) and ≤1,000 ppm fluoride ion elution in a hot water elution test at 100°C for 1 hr. The powder is manufactured by melting a raw material mixture by high frequency induction heating. In the method, an oxide, carbonate or fluoride of Na, Mg, Al and Si are mixed so that the ratio of Na, Mg, Al, Si and F in the raw material mixture is 95 to 105 mol% of the theoretical formula composition of the synthetic sodium phlogopite to be used. The elution of fluorine ions is controlled to ≤20 ppm by further heating the resultant synthetic sodium phlogopite powder to 600 to 1,350°C.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI