anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a physiologically active composition by paying attention to the cell activating action, flood purifying action, blood flow ameliorating action, antiulcer action, and active oxygen-elimination action of an extract of bamboo grass and using an extract of soybean and/or an extract of Juncus in combination to obtain a fermented liquor by Bacillus subtilis, and a cosmetic and a food and drink containing the same.  &lt;P&gt;SOLUTION: The composition comprises a fermented liquor obtained by fermenting an extract of bamboo grass, an extract of soybeans and/or an extract of Juncus with Bacillus subtilis. The cosmetic for preventing rough dry skin comprises this composition. The health food and drink comprises this composition. The composition, cosmetic, and food and drink use Sasa senanensis or Sasa veitchii as the bamboo grass.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To solve the problem that since the current law of Japan makes it obligatory to manage the medical chart information of a patient by a paper medium, it is difficult to completely integrate the medical charts into electronic one, and it is necessary to execute the double management of paper medical charts and electronic medical charts obtained by integrating the medical chart content into electronic information.  &lt;P&gt;SOLUTION: A paper medium embedded with an RFID chip 231 for enabling the reading/writing of electronic data without contact is used as paper medical charts 230, and medical chart information in the RFID chip 231 is read by an RFID reader/writer 201 in an RFID controller 200, and displayed on a medical examination room PC250 so as to be provided to a person 251 in charge of medical examination. Also, the medical chart information updated by the person 251 in charge of medical examination is additionally recorded in an RFID chip 231 in the same way. Thus, electronic medical charts are obtained by an RFID chip 231 integrated with the paper medical charts 230. Therefore, it is possible to execute the unitary management of the paper medical charts and the electronic medical charts, and to attain the authentication of a patient and the efficient administrative operation of the personal information.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
The present invention relates to a method and system for planning a stability study of a pharmaceutical composition. According to the current invention a new statistical principle for designing studies is provided. It addresses directly that the aim of the stability study is to derive more precise and efficient specification limits. The method involves making estimates of the needs that might be encountered and in that way determine whether a given stability study model can provide the precision necessary to derive appropriate shelf-life specifications. The approach is based on utilizing normal distribution calculations of the obtainable specifications in Allen&#39;s formula. The terms that are estimated include the degradation rates such that in the estimated model, the specifications arrived at have at least a 90% chance of being better than projected by other methods. In addition the standard evaluation of the uncertainty of the slope is performed. Data at accelerated temperatures are other conditions may also be included to increase precision.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a means for improving the stability of urea with time, suppressing a greasy feeling of use and stabilizing a coating on an inner wall of a spraying can in an aerosol preparation containing the urea formulated at a high concentration and further a chemical insoluble or sparingly soluble in water and soluble in a lower alcohol formulated therein.  &lt;P&gt;SOLUTION: The urea is combined with a specific substance, concretely a higher fatty acid, an acidic amino acid, salicylic acid or a salicylic acid derivative and resultant mixture is contained in a stock solution of the aerosol preparation. Furthermore, the chemical insoluble or sparingly soluble in water and soluble in the lower alcohol is formulated together with water and the lower alcohol to provide a soluble or solubilized stock solution. Dimethyl ether, or the like, are preferably used as a propellant. Thereby, it is found that a refreshing feeling of use stable with time without greasiness is obtained and even corrosion of the coating on the inner wall of the spraying can is suppressed.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide the use of a molded contact lens in combination with a pharmaceutical composition suitable for delivering to the eye.  &lt;P&gt;SOLUTION: The molded contact lens is preferably marketed and is not specially designed for orthokeratology. A factor (e.g. hyaluronidase) in the pharmaceutical composition forms the cornea of the eye to correct ametropia of the eye. The contact lens and the pharmaceutical composition cause change of the radius of curvature of the front surface of cornea to correct ametropia of the eye. One of advantages of the technique of the invention is to control the treatment for individual patients having visual necessity to satisfy the necessity to near visual acuity and distance visual acuity of the patient. A kit is also provided. The kit includes the molded contact lens, the pharmaceutical composition suitable for a system for delivering to the eye and an instruction.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
The present invention relates to a safflower yellow orally disintegrating tablet and a preparation process thereof. The safflower yellow orally disintegrating tablet has the effects of coronary arteriae dilation, antioxidation, myocardium protection, blood pressure decrease, immunodepression and brain protection, etc. The present invention aims at making up for the preparation insufficiency of existing safflower yellow preparation and providing a safflower yellow orally disintegrating tablet and a preparation process thereof for all patients and medical workers; the safflower yellow orally disintegrating tablet has the advantages of convenient use and rapid absorption and effect-taking. Safflower yellow is used as raw material; filling agents, disintegrating agents, corrigents, flow aid, lubricating agents, etc. are used as auxiliary materials; adhesives or coating materials can also be used according to different situations; appropriate quantity of effervescent agents can be added on specific situation; the orally disintegrating tablet is prepared by a specific preparation method and obtained after tabletting by tabletting machines. The orally disintegrating tablet of the present invention has the characteristics of good friability, rapid disintegration, good taste, no gravel feel, no need of specific production condition, low production cost, convenient carry, storage, transportation and use, etc.; most of all, the orally disintegrating tablet can be taken without water and takes effect quickly, and therefore, the present invention improves the patient&#39;s compliance and enhances the curative effect of the medicine.
PURPOSE:To obtain an aerosol preparation for nasal cavity application, having durable activity, effective at a small amount of application and free from side effects, by suspending oxaprozin powder in liquefied propellant gas. CONSTITUTION:Oxaprozin powder having particle diameter of 1-50mum preferably 5-25mum is added to a liquefied propellant gas such as liquefied petroleum gas or chlorofluorocarbon (e.g. flon 12 or flon 22) which are conventional propellant gases for medical aerosol agent. The amount of the powder is 0.5-10wt.% based on the whole composition. The particles are suspended in the liquefied propellant gas by mixing the propellant gas with a liquid produced by dissolving (A) a nonionic liquid surfactant (e.g. higher fatty acid sorbitan ester such as Span 80 or Span 83) having an HLB of &lt;=10 sand giving low irritancy to nasal mucosa in an amount of 0.1-1wt.% (based on the whole composition) in (B) a solvent (e.g. flon 11) compatible with the liquefied propellant gas.
FIELD: veterinary science. SUBSTANCE: the present innovation deals with immunological diagnostics of larval cestodoses, echinococcoses, in particular. The suggested method deals with simultaneous preparing primary cell culture out of protoscoleces of cestodes and cultivating protoscoleces&#39; cells. Then one should obtain passaged cell culture and select diagnostically active series of cellular metabolites by applying immunoenzymatic reaction. Also, the method deals with possibility for cryoconservation of passaged culture cells followed the stage of its obtaining. The method in question enables to obtain antigen at 87.09- 95.30% sensitivity and 81.9-90.2% specificity. It could be applied in medicine for obtaining highly sensitive and highly specific antigen for predicting echonococcoses. EFFECT: higher efficiency. 4 ex, 2 tbl
PROBLEM TO BE SOLVED: To obtain a preparation for external use for skin excellent in effect capable of protecting skin from ultraviolet light and satisfactorily controlling condition of skin after sunburn by combinedly using an ultraviolet light protecting agent and an extract from tree sprout of a specific plant. SOLUTION: This preparation is obtained by combining an extract obtained by extracting tree sprout belonging to the genus Fagus of the family Fagaceae with a solvent such as water, ethanol or methanol with one or two or more kinds of ultraviolet light protecting agents. Young sprout is highly effectively used as the sprout of the plant of the genus Fagus. The extract is preferably blended in an amount of 0.0001-30.0wt.%, especially 0.001-10.0wt.% based on the preparation. The ultraviolet light protecting agent is preferably blended in an amount of 0.01-30.0wt.%, especially 0.1-20.0wt.%. The ultraviolet light protecting agent includes 2-(2&#39;-hydroxy-5&#39;-methylphenyl)benzotriazole.
PCT No. PCT/JP96/03015 Sec. 371 Date May 29, 1998 Sec. 102(e) Date May 29, 1998 PCT Filed Oct. 17, 1996 PCT Pub. No. WO97/14705 PCT Pub. Date Apr. 24, 1997Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P&#39;-bistocopheryl hypophosphate and/or a salt thereof (P,P&#39;-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P&#39;-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P&#39;-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P&#39;-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.
&lt;P&gt;PROBLEM TO BE SOLVED: To simply form a fine marble pattern having high sensuousness on the surface of a cosmetic.  &lt;P&gt;SOLUTION: A plurality of slurry cosmetics having different color tones are packed into a cosmetic dish 2. Wire rods 4b arranged facing the opening part of the cosmetic dish 2 are inserted into the cosmetic dish 2. The packed material in the cosmetic dish 2 is stirred by relative displacement between the wire rods 4b and the cosmetic dish 2 to form a marble pattern. After removal of the wire rods 4b inserted into the cosmetic dish 2, the stirred packed material in the cosmetic dish is pressed.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PURPOSE:To provide an enzyme-containing foamable bath agent having good and persistent foamability, mild waste product-decomposing action and mild skin cleansing action by compounding a N-acyl-N-methylmelamine salt, etc., as a foaming base material. CONSTITUTION:The subject agent contains an enzyme and a N-acyl-N- methylalanine salt or a N-acyl-N-methyltaurine salt as a foaming base material. The agent may further contain an inorganic salt such as sodium bicarbonate or sodium sulfate. a protease or lipase is preferably compounded in an amount of &gt;=0.1wt.% as the enzyme. the foaming agent is compounded in an amount of 30-80wt.%, preferably 40-60wt.%. The base material does not lower the foamability thereof even in hard water, does not unstabilize the enzyme and does not affect the activity of the enzyme.
PURPOSE: To obtain a medicament containing tilmicosin and used for the treatment of mastitis in ruminants. CONSTITUTION: This medicament for the treatment of mastitis in ruminants contains a compound of formula I [R is a secondary amino group expressing a carbon cyclic system selected from a monocyclic ring group of formula II having 5-16 cyclic members excluding the N atom, a 8-20 membered bicyclic or tricyclic group, and a cyclic group substituted by a 1-4C alkyl, a 2-4C alkenyl, a 1-4C alkoxy, cyano, amino or phenyl; R&lt;3&gt; is hydroxy, a 1-5C alkanoyloxy, etc.], as an active ingredient. The compound of formula I or its acid adduct is hypodermically injected into a female ruminant in relation to pregnancy &gt;=25 days ago from the birth. When the ruminant already secretes milk, the ruminant is not milked and maintained until the birth.  The medicament is used for the ruminants, especially cows, and hypodermically administered at a dose of 0.5-10mg/kg body without limiting to cows of non-milking periods.
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors, of the kainate binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commerical significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation. &lt;IMAGE&gt;
Therapeutic compositions for application to the skin in the treatment of acne comprise a suspension of an inorganic abrasive having a harness greater than 7, as measured by Moh&#39;s index, being non-piezo-electric and having a particle size distribution within the range of 125 microns to 710 microns, in a non-oleaginous paste comprising a surface active agent and a solvent therefor, which is non-poisonous and non-irritating to the skin.  The preferred abrasive is fused, synthetic aluminium oxide and the surface active agent may be cationic, anionic or non-ionic.  The solvent is preferably water but may also be an organic liquid.  An emollient may be included in the non-oleaginous paste, e.g. lanolin, glycerine, polyethylene glycol or a fatty acid ester of polyethylene glycol.  Other optional ingredients which may be included are pigments, bentonite, and bactericides, e.g. hexachlorophene, 3, 4, 41-trichlorocarbanilide and bithionol.  In a course of treatment for acne, a coordinated series of compositions according to the invention may be used, in which the proportion of coarse to fine particles of the abrasive and the proportion of abrasive to non-oleaginous paste are both successively increased in successive stages of the treatment.
This uses for the soaking-bath to bathe the package, the use agalloch eaglewood, the honey suckle, the Chinese mugwort, the commeeina, chang the water&#39;s edge, the lophantusrugosus, the frankincense natural herb union becomes, most mainly may 1. Relieve fstigue: Extends after detachably, causes the whole body to be happy. 2. Help sleep: The affable mood, helps you to rest fragrantly. 3. Maintains the skin: When soaking-bath will perspire massively, but the draw-off plug in pore waste, will let the skin thorough clean, will become has the gloss. 4. To is sensitive to cold the physique to have the improvement: In the winter the hands and feet ice-cold person, is helpful to improve the physique frequently Simply speaking, it is in the tepid water, joins has the benefit fragrant herbaceous raw material for medicine regarding the human body, because of the hot compress and the hydrotherapy way, promotes human body&#39;s health and beautiful, and can transport the body and mind, the command spiritedly peaceful, to fumigate stimulates, the happy physique, to evade fragrant eliminates unlucky, bathes only filthily, achieves the health care keeping in good health the effect, then the guard or is not suitable for however.
Disclosed are human K+ channel polypeptides and DNA (RNA) encoding such K+ channel polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques. Agonists for such K+ channel polypeptides are also disclosed. Such agonists may be used to treat epilepsy, stroke, hypertension, asthma, Parkinson&#39;s disease, schizophrenia, anxiety, depression and neurodegeneration. Also disclosed are antagonists against such polypeptides which may be used to treat AIDS, SLE, diabetes, multiple sclerosis and cancer. Also disclosed are diagnostic assays for detecting mutations in the polynucleotide sequences of the present invention.
PURPOSE:To obtain the subject drug capable of improving the growth, etc., of domestic animals due to participation in keeping the balance of gut flora and capable of pelletizing by blending a hydrocarbon component derived from grains and tubers with spore-forming viable cells belonging to Bacillus genus. CONSTITUTION:An aqueous dispersion is prepared by using a hydrocarbon component derived from grains (corn powder, rice bran, etc.) and tubers in an amount of 0.01 pts.wt. (preferably 0.1-10 pts.wt.) based on 1 pts.wt. spore- forming cells belonging to Bacillus genus (preferably Bacillus toyoi) containing &lt;=about 10&lt;13&gt;-10&lt;15&gt; viable cell per 1kg cell weight) and subsequently subjected to spray drying, etc., to obtain the objective drug. By mixing the above- mentioned drug into a feed, etc., for animals and pelletizing the resultant mixture by a pelletizer, the subject pellet-shaped feed can be obtained.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a cleaning agent useful for stainings by a mineral oil, animal and vegetable oils, paint and the like by using a scrubbing agent which does not lose cleaning effect and selecting a scrubbing agent which does not clog piping and is soluble in water in a natural environment such as a river.  &lt;P&gt;SOLUTION: The cleaning agent for stainings by a mineral oil, animal and vegetable oils, paint and the like comprises a solvent, a surfactant and a water soluble abrasive, and optionally comprises a thickening agent, a neutralizer, a moisturizer and purified water. The solvent includes an alcohol solvent, an ester solvent, a ketone solvent, a hydrocarbon solvent and a nitrogen-based solvent. The surfactant includes a nonionic surfactant or an anionic surfactant. The water soluble abrasive includes sodium chloride, sodium sulfate, ammonium chloride, potassium chloride, ammonium sulfate, sodium hydrogen carbonate, aluminum ammonium sulfate, aluminum potassium sulfate, borax, ammonium borate and the like.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
The invention relates to new chemical compounds which can be used as analgesic drugs and their preparation. The new chemical compounds have the general formula: &lt; IMAGE &gt; in which: R is a lower alkyl R1, which is always other than H, is a linear or branched lower alkyl, an allyl, amino alkyl of type &lt; IMAGE &gt; in which n=2 to 4, R2R3 represent a lower alkyl they may also form a heterocycle with the nitrogen atom. Y is a hydrogen, halogen, lower alkyl, alkoxy, &lt; IMAGE &gt; R being a lower alkyl. The position of Y is variable on the ring. X=oxygen or sulfur atom. The drugs containing these active principles may be used in the treatment of rheumatismal disturbances and various pains.
Systems and techniques that facilitate automated localization of large vessel occlusions are provided. In various embodiments, an input component can receive computed tomography angiogram (CTA) images of a patient&#39;s brain. In various embodiments, a localization component can determine, via a machine learning algorithm, a location of a large vessel occlusion (LVO) in the patient&#39;s brain based on the CTA images. In various instances, the location of the LVO can comprise a laterality and an occlusion site. In various aspects, the laterality can indicate a right side or a left side of the patient&#39;s brain, and the occlusion site can indicate an internal carotid artery (ICA), an M 1  segment of a middle cerebral artery (MCA) or an M2 segment of an MCA. In various cases, a visualization component can generate and display to a user a three-dimensional maximum intensity projection (MIP) reconstruction of the patient&#39;s brain based on the CTA images to facilitate visual verification of the LVO by the user.
The present invention relates to a loosestrife compound preparation for treating liver lithiasis and gallbladder lithiasis and a formulation thereof. The formulation is composed of honeysuckle flower, loosestrife, spora lygodii, chicken&#39;s gizzard membrane, southern radix curcumae, dandelion, baikal skullcap root, radix bupleuri, immature orange fruit, common prism tuber, zedoray rhizome, hemlock parsley, red peony root, red sage root, radix clematidis, radix et rhizoma rhei from Sichuan of China and sodium sulfate. The active ingredients in the medicines are extracted by using the water decocting extraction technology to be decocted and concentrated so that the preparation of the present invention is prepared. The preparation of the present invention can be the medicinal broth, the pill, the powder or other types of preparations. The present invention also is called as hardware niter soup. The present invention is used for treating intrahepatic bile duct lithiasis, choledocholithiasis, gallbladder lithiasis and cholecystitis, and one preparation is taken in five times to realize the effect of relieving pain. Particularly, the compound preparation of the present invention has effect on rapidly dissolving the stones according to the administration method required by the present invention. A large amount of medicine liquid is orally taken in five to six hours to make the blood concentration and the medicine concentration rapidly reach the peak. Thus, the present invention eliminates pain caused by lithiasis in a short time to cure patients with lithiasis.