anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a technique for making distribution of a fibrous substance after coating in a powdery cosmetic readily uniform.  &lt;P&gt;SOLUTION: The powdery cosmetic containing a fibrous substance comprises a polyoxyalkylene-methylpolysiloxane copolymer. The fibrous substance is preferably a nylon fiber which may be colored and/or a hollow titanium dioxide fiber and the nylon fiber which may be colored is preferably a hollow nylon fiber having a cross section having a parallel crosses shape. The nylon fiber which may be colored is preferably colored with purple. The polyoxyalkylene-methylpolysiloxane copolymer is preferably a poly(oxyethylene-oxypropylene)-methylpolysiloxane copolymer.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
FIELD: medicine. ^ SUBSTANCE: group of inventions relates to the field of medicine, more precisely, to preparation of patients for various medical procedures such as surgery, which includes application of solution (or liquid) for local use, such as an antiseptic solution in order to disinfect the target area for medical procedures. Applicator device for application of local antiseptic to the skin contains a handle having a proximal end and distal end; base, connected with the proximal end of the handle; hydrophilic foam, which is connected to the base, and at least one abrasive layer is connected with a hydrophilic foam. Hydrophilic foam is designed to apply local antiseptic on the skin. The abrasive layer and the hydrophilic foam together are suitable for application of local antiseptic on the skin. Applicator system, in turn, contains the applicator device including hydrophilic foam designed to absorb local antiseptic and a case designed to keep at least part of the applicator device. Method of application of local antiseptic to the skin contains application of local antiseptic in the above-mentioned applicator device, and application of local antiseptic, using the applicator device by applying of the required portions of local antiseptic to the target area of skin by contacting the applicator with the skin. ^ EFFECT: invention enables to keep efficiently an antiseptic solution, excluding its leak, it is easy to distribute a required amount of solution to the target area, to facilitate treatment of the target area by scraping the epidermis of the patient&#39;s body to remove bacteria and increase the effectiveness of disinfection. ^ 67 cl, 1 ex, 1 tbl, 8 dwg
The invention comprises a compound designated &#34;previtamin D3,&#34; isomeric with vitamin D3 and convertible thereto without the action of light, and its esters with organic acids; p  the preparation of these substances by chromatography (followed, if desired, by alkaline saponification at a temperature not above 15 DEG  C.) from the mixture of esters of previtamin 3D and vitamin D3 obtained by (a) irradiating 7-dehydrocholesterol, separating unchanged 7-dehydrocholesterol and esterifying the residue, all at a temperature not above 25 DEG  C., or (b) heating an ester of vitamin D3 at a moderate temperature not substantially above 60 DEG  C. in a hydrocarbon solvent containing not more than 12 carbon atoms in the molecule (e.g. benzene); and the conversion of the products to vitamin D3 or its esters with organic acids by heating to a moderate temperature (preferably not above 80 DEG  C.) in a solvent such as benzene.  The chromatography may be effected by adsorption (e.g. from benzene solution) on neutral alumina and elution with ligroin, the previtamin D3 ester being obtained from the least strongly adsorbed fraction and, if desired, recrystallized from methyl ethyl ketone. The previtamin D3 obtained by saponification may be re-esterified by the action of acid chlorides or anhydrides. Examples describe the preparation of previtamin D3 3 : 5-dinitrobenzoate by methods (a) and (b), and its conversion to vitamin D3 3 : 5-dinitrobenzoate. Specification 668,114 is referred to.
PURPOSE:To provide a solid cosmetic containing fine powder of titanium oxide and truly spherical titanium oxide each having respective specific particle diameter, having unique structural characteristics and shear-embrittling property and excellent masking power, spreadable smoothly on the skin and having excellent adhesivity. CONSTITUTION:The objective solid cosmetic having excellent embrittling property and useful especially as a makeup cosmetic can be produced by coordinating (A) a fine particle of titanium oxide having the maximum particle diameter of &lt;=0.1mum and average particle diameter of 0.01-0.05mu in the space between (B) the truly spherical titanium oxide particles having an average particle diameter of 1-30mu, preferably 4-20mu. The weight ratio of A:B in the solid cosmetic base is 1:10-10:1, and the sum of both components is 5-80wt%. EFFECT:The cosmetic has excellent durability on the skin and gives powdery feeling free from oiliness to the skin. It has no stickiness and high adhesivity to the skin. In can be transferred to the cosmetic tool such as puff, brush, etc., or to the skin in the case of direct application.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a collagen peptide derived from fishes, suitably usable for a food and drink and a cosmetic, hardly having taste and smell peculiar to the fishes, and having excellent safety, and to provide a method for producing the collagen peptide, and the food and drink and the cosmetic containing the collagen peptide.  &lt;P&gt;SOLUTION: The collagen peptide derived from the fishes, containing ≤1.0 wt.% free amino acid and ≤2 ppm arsenic based on the solid is obtained by preparing an extract containing the collagen from fish skin and/or fish bone, enzymically hydrolyzing the extract, and concentrating and purifying the hydrolyzed product by using a reverse osmosis membrane. The food and drink, and the cosmetic are obtained by formulating the collagen peptide. Preferably, the collagen peptide has 1,000-10,000 average molecular weight. A step for decoloration or deodorization of the extract containing the collagen or the enzymically hydrolyzed product is preferably included. The reverse osmosis membrane preferably has 10-50% stopping ratio of sodium chloride.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
NEW MATERIAL:An organogermanium polymer expressed by formula I or II (n is an integer &gt;=3). USE:A drug for C.R.D. complexes related to mycoplasmas having very low toxicity such as acute oral toxicity &gt;=10,000mg/kg LD50 for the oral administration to rats. PROCESS:Germanium dioxide is treated with hypophosphorous acid or a salt thereof in a hydrohalogenic acid to give a halogermanium-phosphoric acid complex, which is then reacted with acrylic acid to afford a compound expressed by formula III (X is halogen). The resultant compound expressed by formula IIIis dissolved in acetone or another organic solvent miscible with water, e.g. ethanol, and water is then added to the resultant solution to afford the aimed compound expressed by formula I or II.
The invention discloses a traditional Chinese medicine tincture for treating tenosynovitis and a preparation method thereof. The traditional Chinese medicine tincture is prepared through the combination of radix angelicae sinensis, incised notopterygium rhizome, liquorice, Chinese fevervine herb and root, garden balsam stem, resina draconis and wild ginger, so that the synergistic effect is achieved, therefore, the effects of dispelling cold and removing dampness, dredging tendons and muscles, and promoting blood circulation and stopping pain are effectively achieved. The traditional Chinese medicine tincture prepared through the combination of traditional Chinese medicines conforms to the theory of traditional Chinese medicine, meets requirements of pharmacopoeia of the People&#39;s Republic of China, and has no toxic or side effects to human bodies. After the traditional Chinese medicine tincture is used at an affected part, the effective components of the traditional Chinese medicine tincture can fully permeate through pores so as to achieve the effects of regulating qi and blood, warming channel to remove coldness, and dredging tendons and relieving pain. The traditional Chinese medicine tincture is convenient to carry and use, low in preparation cost, and simple in preparation. Through clinical observation, the total effective rate of the traditional Chinese medicine tincture can reach 100% after being used for treating tenosynovitis for two courses of treatment.
PROBLEM TO BE SOLVED: To provide a new stereoisomeric indole compound having physiological activities such as lipid peroxidation suppressing activity and utilizable as pharmaceuticals and cosmetic materials, etc. SOLUTION: This stereoisomeric indole compound is expressed by formula I [X is a 1-5C alkyl which may be substituted with OH, COOH, benzyl, etc.; R is H, an alkyl, an aralkyl, a cycloalkyl, an aryl, a univalent metal, etc.; R1 and R2 are each H, an alkyl, an aralkyl, a cycloalkyl or aryl; * represents asymmetric carbon atom] or its salt, e.g. (1&#34;S,3&#34;S)-indole of formula II. The compound of the formula I can be produced by condensing L-tryptophan of formula III with a stereoisomeric α-amino acid of formula IV to obtain a compound of formula V and subjecting the compound to oxidative cyclization reaction to construct an oxazole ring at a stroke.
To reduce problems encountered in the &#39;intellectual processing&#39; of the data of haematoloqy by providing an instruction for retrieving a message applied to the parameter value of a patient from a memory means by the combination of the range in a stored execution instruction and supplying the message by a form for making the solution of the blood state of the patient possible.  This device is provided with a computer 10 such as a personal computer and the computer 10 is provided with a normal memory device 20, a central processing unit and peripheral devices such as a printer 14 and an examination screen 12. Then, inside the memory device 20, a so-called knowledge base applicable to blood diagnostics and a command based on which the device processes input data are stored. The device is also provided with a means 16 for inputting the input data inside the device. Thus, the device executes the command and prints out applicable haemotoloqy messages and diagnostic messages. At the time of the interpretation operation of the data of the haemotology, the help of the expert level of a computer base is given to a doctor.
PURPOSE:To obtain an agent capable of preventing ascites of broiler and improving the rearing rate by using a specific quinone compound as an active component. CONSTITUTION:A quinone compound of formula (Y and Z are H, CH3 or together form one covalent bond of the double bond between C and C&lt;2&gt;; n is 1-11) is used as an active component of an agent for preventing ascites of broiler and an agent for improving the rearing rate of broiler. A feed for broiler is produced by compounding one or more kinds of the compound of formula I. The ascites of broiler is prevented and the rearing rate is improved by feeding a broiler of &gt;=4 weeks old with one or more kinds of agents selected from the agent for preventing ascites of broiler, an agent for improving the rearing rate of broiler and the feed for broiler. When the agent is administered to a broiler having especially high oxygen demand, the energy requirement of the heart of the broiler is satisfied, the ascites is prevented and, as a result, the rearing rate is improved. The quinoline compound is preferably administered to a broiler at a rate of 0.05-50mg/kg body weight per day.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a clinical information management and delivery method and a clinical information management and delivery apparatus that ensure high convenience, universality and data continuity.  &lt;P&gt;SOLUTION: Clinical information data in a format other than universal image formats created on an input and editing terminal (1) is saved in an information repository (3). The clinical information data is read out from the information repository (3) and provided for the input and editing terminal (1), and is also provided through conversion into image data in a universal image format in a rendering part (4). The clinical information data completed on the input and editing terminal (1) is converted into image data in the universal image format in the rendering part (4) and saved in a management repository part (5). The image data is read out from the management repository part (5) and provided in response to a delivery request from a referring terminal (9).  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a sterol compound-containing powder composition which is easily dispersed in water and has good handleability, to provide a compression-molded article which can contain the sterol compound in a high content without causing a tableting trouble, by formulating the powder composition in a high content, to provide a production method, and to provide a use.  &lt;P&gt;SOLUTION: This sterol compound-containing powder composition comprising (A) the sterol compound and (B) a saccharide or protein as essential components is characterized by coating 0.01 to 85 pts. wt. of the component (A) with 1 to 50 pts. wt. of the component (B), wherein the total amount of the powder composition is 100 pts. wt.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
The invention relates to the testing of humans or other animals, such as horses, cattle or dogs, for allergic reaction or hypersensitivity to penicillins. The tests can be used both to predict and to diagnose allergy. The invention comprises new penicilloyl-polylysine (PPL) preparations, new materials for use in minor determinant mixture (MDM) compositions and novel test methods employing such materials. The new PPL preparations comprise homogeneous, high purity, maximally coupled,  alpha -diastereoisomeric, penicilloyl conjugates of low molecular weight PPLs. The PPL materials of the invention have the molecular structure in accordance with the following generic formula: &lt;IMAGE&gt;   wherein: R is selected from the group consisting of H and penicilloyl groups or similar groups derived from cephaolosporins or other  beta -lactam antibiotics; and n is an integer of from 4 to 10, at least about 66% and up to 100% of the R groups are other than hydrogen. Solutions containing this PPL material are useful in skin testing for penicillin allergy or hypersensitivity alone, but preferably are utilized in a two-part test with MDM solutions containing the novel MDM materials of the invention. The new MDM materials are N-penicilloyl amines of an aliphatic amine or  alpha -aminoacid having the following molecular structure:   &lt;IMAGE&gt; wherein: R1=a side chain which defines the type of penicillin-e.g., where R1=   &lt;IMAGE&gt;  the new material is a derivative of benzylpenicillin; and R2 is an alkyl group of C2-C6 length, preferably ethyl or propyl, or an aminoacid residue as described herein. The tests are preferably carried out by applying solutions of the materials to the skin of the patient or other test animal and pricking or scratching the skin, or by injecting the materials intradermally, and then observing for wheal and flare reactions. The preferred test method comprises a two-solution test using a solution of the novel PPL preparations applied on or into one area of the patient&#39;s skin and a separate solution containing the new minor determinant material alone or as part of an MDM solution with other constituents applied on or into another area of the patient&#39;s skin.
PURPOSE:To obtain a skin detergent, having a moderate viscosity and excellent in stability without any stickiness of the skin during washing and dryness of the skin after drying. CONSTITUTION:A skin detergent is obtained by blending (A) one or more anionic surfactants, especially alkyloylalkyltaurine salts with (B) one or more selected from amphoteric surfactants and semipolar surfactants used as usual cosmetic bases and (C) one or more higher fatty acids expressed by the formula R&lt;1&gt;COOH (R&lt;1&gt; is 7-25C saturated or unsaturated hydrocarbon group having straight-chain or branched chain or OH) as essential ingredients at 0.002-1, preferably 0.05-0.5 weight ratio of the ingredients [(C)/(A+B)]. The amounts of the blended ingredients in the whole skin detergent are 5-50wt.%, preferably 8-30wt.% total amount of the ingredients (A) and (B) and 0.1-5wt.% ingredient (C). The resultant skin detergent has the aforementioned effects. Furthermore, if an unsaturated fatty acid such as oleic acid is used as the ingredient (C), stability, especially the stability at low temperatures is remarkably improved. Thereby, the detergent can also be used in cold districts.
PROBLEM TO BE SOLVED: To obtain an anticariogenic composition capable of suppressing production of glucan due to bacterium causing dental caries by including α- mannooligosaccharide. SOLUTION: This anticariogenic composition comprises an αmannooligosaccharide. The α-mannooligosaccharide consists mainly of an oligosaccharide obtained by bonding 2-10 mannoses at α-position and the bonding includes α-1,1, α-1,2, α-1,3, α-1,4 or α-1,6 bond. Such α-mannooligosaccharide is obtained by a method decomposing mannan of cell wall, etc., of microorganism with oxygen or an acid, a method, etc., carrying out condensation reaction of α-mannosidase from mannose. Further, commercially available α- mannooligosaccharide can also be used as the α-mannooligosaccharide. A composition for oral cavity or beverage and food are exemplified as the anticariogenic composition and preferable concentration of the α-mannooligosaccharide in these compositions is 0.01-5 wt.%.  It is desirable to ingest the beverage or food in an amount of &gt;=1 g, preferably &gt;=5 g/day when the beverage or food is ingested in order to prevent caries.
PROBLEM TO BE SOLVED: To prepare a synthesis suppressant for a protein belonging to the HSP27 family comprising a malt extract. SOLUTION: This synthesis suppressant comprises 0.01-99wt.% malt extract as an active ingredient and has suppressing activities against the synthesis of a protein, belonging to the heat shock protein family (HSP27 family) and having 16-40 kDa molecular weight. Autoimmune diseases such as multiple sclerosis concerned with the onset of cancers in which the protein belonging to the HSP27 family is related to the malignant alteration thereof or reduction in hyperthermic effects can effectively be treated by administering the malt extract. Medicine resistance can be suppressed and chemotherapeutic effects can be enhanced by suppressing the expression of the protein belonging to the HSP27 family.  The malt extract is obtained by saccharifying malts, filtering the resultant saccharified malts, extracting the prepared filtration residue of the saccharified malts with water or a hydrophilic solvent or a mixture solution thereof and removing a fraction of a low-molecular compound having &lt;10000 molecular weight. The daily dose for an adult is 1mg to 10g expressed in terms of the malt extract.
NEW MATERIAL:A compound expressed by formula I (R1 is 8-20C long-chain alkyl, resin acid side chain, etc,; R2 is side chain of constituent amino acid of casein-derived polypeptide; n is an integer of 3-20; M is H, onium of alkali metal, etc.) or salt thereof USE:An additive for hairdressing cosmetics, e.g. shampoo, rise, etc., principal ingredient in cosmetics, e.g. lotion, etc., having excellent surface-active action and mild action as well as protecting action on the skin or hair, regenerating action on damaged hair, etc., with hardly any irritation to the skin and mucosae. PREPARATION:For example, cow&#39;s mild casein is dissolved in an aqueous solution in a high concentration, e.g. urea, etc., and hydrolyzed with a proteolytic enzyme, e.g. pepsine, etc., at 30-45 deg.C for 3-24hr. An acid chloride derivative of a higher fatty acid expressed by formula III is added to an aqueous solution of the resultant casein-deived polypeptide expressed by formula II which stirring at pH 8-10 to acylate the compound expressed by formula II.
An extract of Magnolia officinalis Rehd. et Wils. is provided to inhibit activity of beta and gamma-secretase concerned in other-amyloid formation, thereby being effectively used as a functional food or a pharmaceutical composition for treating or preventing amyloid-related diseases. A composition for treating or preventing amyloid-related diseases comprises 0.0001-90 wt.% of an extract of Magnolia officinalis Rehd. et Wils. as an effective ingredient, wherein the amyloid-related disease is Alzheimer&#39;s disease, Down&#39;s syndrome, cognitive disorder, memory impairments or amyloidosis.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a new glycoside or glycoside mixture which has a sweet taste similarly to α-glucosylglycerol, has low Maillard reactivity, dental caries resistance and high moisture retainability, a lower sweet degree than that of the α-glucosylglycerol, is stable in a wide pH range under heating, and further has a good α-amylase activity-inhibiting action, a good starch ageing-suppressing action, a good protein denaturation-suppressing action, a good vitamin-stabilizing action and a good calcium-solubilizing action, to provide a method for producing the glycoside or glycoside mixture, by which the glycoside or glycoside mixture can efficiently and simply be produced at low costs, and to provide the uses of the glycoside or glycoside mixture.  &lt;P&gt;SOLUTION: The glycoside comprises a maltooligosaccharide and glycerol in a ratio of one molecule : one molecule through an α-glucoside bond. The glycoside mixture. The method for producing the glycoside or glycoside mixture comprises treating a mixture of glycerol with α-glucan with a cyclodextrin-synthesizing enzyme. A drink, a food or the like contains the glycoside or glycoside mixture. The method for producing the α-glucosylglycerol comprises treating the glycoside or glycoside mixture with glucoamylase.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
PURPOSE:To obtain a diabetic remedy having excellent lowering activity against amount of blood sugar, comprising dried powder or an extract of earthworm as an active ingredient. CONSTITUTION:Castings in digestive tube of live earthworm are vomited, dirt attached to the earthworm is washed with water, removed or the above- mentioned operations are carried out in the reverse order. The earthworm is ground in a wet state to give a suspension, which is frozen at -10--60 deg.C. Then freezing and vacuum drying are carried out in a temperature range of -60-80 deg.C at &lt;=10mmHg degree of vacuum for 10-100hr while stepwise raising temperature and the final process of the freezing and vacuum drying is done at 70-80 deg.C for 0.01-0.5mmHg for 5-10hr to give dried powder of earthworm. The suspension or the dried powder in the operation is extracted with an extractant selected from an aqueous solvent, a water-miscible solvent or a water- immiscible organic solvent and the extracting solvent is removed to give an extract. A diabetic remedy contains the dried powder or the extract obtained by the operation.
PURPOSE: To obtain an oral compsn. contg. aminoalkylsilicone and a lipophilic compd., improving the holding of the lipophilic compd. on the surfaces of teeth and producing a residual effect for a long period of time. CONSTITUTION: This oral non-food compsn. contains a water-in-oil emulsion consisting of an oil phase (A) contg. acrylic hydrophobic aminoalkylsilicone (A1 ) preferably having a mol.wt. of &gt;=5,000, especially 5,000-30,000, an orally allowable lipophilic compd. (A2 ) soluble in the component A1 , preferably an antibacterial agent, and a flavor and an aq. phase (B) contg. such an effective amt. of an emulsifier as to disperse the oil phase in the aq. phase, preferably a nonionic or cationic emulsifier. The amts. of the components A1 and A2 and the emulsifier in this compsn. are preferably 0.1-20 wt.%, 0.01-10 wt.% and 0.05-10 wt.%, respectively.  When the component A1 forms a residual thin film on the surfaces of teeth, the component A2 is incorporated as part of the film, the deposition of the component A2 on the surfaces of the teeth is promoted and prolonged and a sustaining effect is produced.