anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
Compounds (I) (A=2-furyl, substituted 2-furyl, 2-tetrahydrofuryl, substituted alkoxy or substituted phenoxyalkyl; B=B1, B2 or B3, but if B=B1 then A=substituted phenoxyalkyl) and their enantiomers, diastereoisomers and pharmaceutically acceptable salts are useful for the preparation of a medicament for the treatment of sexual dysfunction in males and females. Compounds II (I:B=B3, A &lt;&gt; 2-furyl) are novel and are claimed per se. Pharmaceutical compositions containing compounds II are also claimed, as are pharmaceutical compositions containing compounds I and one or more of a prostaglandin, a direct vasodilator and a 5 cGMP phosphodiesterase inhibitor (e.g. sildenafil). Compounds which bind to mammalian alpha1b adrenergic receptors with an affinity of at least about 10-8 M and which bind to mammalian alpha1b adrenergic receptors with an affinity at least 10-fold higher than the affinity with which the compound binds to mammalian alpha1a or alpha1d alpha1L adrenergic receptors are also useful for the preparation of a medicament for the treatment of sexual dysfunction in males and females. A method of identifying such compounds is also disclosed and claimed.
A composition and method of preventing a lysosomal leakage from eukaryotic cells is based on a 6-methyluracil based water-soluble compound. The cells are being exposed to a water solution of such compound for the duration of a sub-optimal condition such as a temperature shock, starvation, radiation, etc. The optimum concentration of the compound is ranging from 1 to 1000 micrograms per milliliter of a solution. The preferred concentration is from 10 to 500 mkg/ml. The most advantageous composition from the group is a complex of 2,4-dihydroxy-6-methylpyrimidine with N-methyl-D-glucamine. Besides cell preservation, the composition is useful for a treatment of a variety of medical conditions characterized by excessive or inappropriate apoptosis such as ischemia, type I diabetes, stroke, Alzheimer&#39;s, and Parkinson&#39;s diseases. The composition is also useful in yeast production, food preservation, and other applications.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a food and drink (health food), a pharmaceutical, an arteriosclerosis preventing agent and an agent for suppressing oxidative denaturation of LDL capable of effectively suppressing the oxidative denaturation of LDL (low-density lipoprotein) in blood.  &lt;P&gt;SOLUTION: The food and drink, pharmaceutical, arteriosclerosis preventing agent and agent for suppressing oxidative denaturation of LDL contain a flavonoid aglycone derived from lemon as an active component. Examples of the flavonoid aglycone are eriodictyol and diosmetin. These flavonoid aglycones can be produced by converting flavonoid glycosides derived from lemon into aglycone. The aglyconization is carried out e.g. by β-glucosidase treatment or microbial fermentation with microorganisms of the genus Aspergillus.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
Discrete capsules, each consisting of a single, substantially p water-insoluble core entity surrounded by an encapsulating wall consisting of a plurality of hydrophilic colloid materials, at least one of which is gellable, are prepared by forming a dispersion of the core material in an aqueous dispersion of the colloid material, causing complex coacervation of the said colloid material some of which coats the core particles, effecting decoacervation (i.e. redispersion) of the remnant colloid material, adding supplementary colloid material, and again causing complex coacervation whereby a further coating of colloid material is deposited on to the first coating.  The coating may subsequently be gelled, e.g. by chilling and, if desired, hardened or plasticized.  The core material may be liquid, e.g. an animal, vegetable, mineral or partly or wholly synthetic oil, a solid or a solid dispersed in a liquid and it may be a food, drug, dye, chemical reactant, perfume, flavouring, electrostatic or magnetic material.  Specified colloid materials are gelatin, gum arabic and ethylene-maleic anhydride copolymer (molecular weight about 1000 to 2000 and 50,000 to 70,000).  It is preferred that the latterly deposited colloid &#34;complex&#34; is similar but not identical to that deposited initially, e.g. the first may consist of the copolymer of molecular weight 1000 to 2000, gelatin and gum arabic and the second may differ in that the copolymer is of molecular weight 50,000-70,000.  Coacervation and decoacervation may be effected by known methods, e.g. variation of pH or temperature, the process being carried out under continuous stirring at a temperature above the gel point of the gelable colloid. Specification 757,100 is referred to.
A data-logger processes the data received from multiple sensors (e.g. gathering physiological data about a person) in accordance with priorities stored in memory. The data-logger may cause the sensors to transmit data in accordance with these priorities or may dynamically control the manner in which they sample and/or buffer data. It may also prioritise the storage, compression or encryption of data received from a sensor of relatively high priority over that of other sensors. Moreover, the data logger may dynamically allocate wireless channel bandwidth to each sensor according to the stored priorities and/or so as to prevent data transmission rates from exceeding processing rates. It may onward-transmit the sensor data to a remote server in a prioritised manner and/or in accordance with a power-management strategy. Thus sensor and data-logger battery-life may be prolonged; bandwidth allocation to sensors effectively managed; and `graceful&#39; gradual managed degradation of the service may be achieved in accordance with relative data criticality.
This invention relates to a Tongluo-Zhuifeng ointment prepared from Radix Saussureae Lappae, Taishen, Cyathula officinalis kuan and sesame oil etc. 12 kinds of Chines mecind. Said medicines are decocted by using sesame oil, filted to remove dreges and put into cold water to remove heat and toxicant. It&#39;s effective rate is 100% and the curative rate is 95%. Said ointment can be used for treating rheumatism, atrophic arthric hemiplegia and paralytic etc. and has no side and toxic effect and is convenient for use.
Compositions and immunoassays for detecting SARS-CoV-2 antigen-specific antibodies in a biological sample are provided. The compositions are antigens from SARS-CoV-2 such as the proteins N, M, S, S1, S2&#39;, NSP1, ORF3a, ORF3b, ORF7a, ORF7b and ORF8, fused to a light emitting protein. The compositions are useful in immunoassays for detecting antibodies to the SARS-CoV-2 antigens. A preferred immunoassay is the luciferase immunoprecipitation systems (LIPS) to detect SARS-CoV-2 antigen-specific antibodies with high sensitivity and specificity. The current or present exposure or infection with SARS-CoV-2 can be detected and/or diagnosed using the disclosed compositions and methods. Typically, the presence and/or elevated amount of SARS-CoV-2 antibodies in the individual&#39;s biological sample compared to a control is indicative of current or past exposure or infection with SARS-CoV-2 as discussed herein.
PROBLEM TO BE SOLVED: To obtain an immunostimulating agent prepared using a support, capable of supporting a super antigen of a factor to activate a T-cell without losing its bioactivity and having no toxicity against a living body. SOLUTION: This immunostimulating agent is obtained by absorbing a super antigen (e.g. a staphylococcal intestinal toxin) on a calcium phosphate compound (e.g. hydroxyapatite) having Ca/P ratio of 1.0-2.0. The calcium phosphate compound is a particulate material having an average particle diameter of 0.1-10,000μm, and the compound is used as it is without drying after the synthesis in a liquid phase or thermally treated at &lt;=700 deg.C before using. The calcium phosphate compound has strong absorption activity on a super antigen, and therefor can absorb the super antigen by bringing the calcium phosphate compound into contact with the super antigen. In this process, the super antigen is dissolved in an isotonic phosphoric acid buffer solution before using.  It is preferable that in the immunostimulating agent, an unabsorbed sites is optionally blocked with a blocking agent such as casein. In an immunotherapy of cancer, etc., the immunostimulating agent can enhance its therapeutic effect when used in a drug delivery system capable of effectively bringing the agent to a lesioned part.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely rehabilitation medicine, physiotherapy and urology and may be used for the purpose of rehabilitation of the patients suffering urolithiasis following lithitripsy. That is ensured by the intake of the herbal tea &#34;Veres&#34; containing wild camomile blossom, knotgrass herb, nosebleed herb and horsetail herb, juniper fruits, sage leaves, birch leaves, red bilberry leaves, linseeds taken in equal proportions. The infusion is taken in a dose of 100 ml 3 times a day 30 minutes before meals for 5-7 preoperative days. The common background therapy follows the lithotripsy procedure. That is combined with the additional intake of the herbal tea &#34;Veres&#34; for 10 days following the above procedure and hydrocarbonate sulphate calcium-magnesium mineral water &#34;Kazachinskaya&#34; of mineralisation 1.44g/l for 24 days following lithotripsy. The mineral water &#34;Kazachinskaya&#34; is taken in a dose of 200-250 ml 3 times a day before meals. Further, after the lithotripsy procedure, a projection of the involved kidneys and renal duct is exposed to the apparatus Bemer-3000 at AC field frequency 30-1000 Hz and magnetic field intensity 8.5-100 mcT. The exposure is generated by an intensive contact applicator from 2 fields in the mode-1 (2-4 stages) of 8 minutes. The therapeutic course makes 10 daily procedures. The background therapy is followed by another one-month intake of the herbal tea &#34;Veres&#34;, as well as by another exposure to the apparatus &#34;Bemer-3000&#34; at the same parameters of the electromagnetic field. The contact exposure also covers the kidneys and the lower one-third of the renal duct by means of the intensive application from 2-4 fields in the mode-2 (2-4 stages) of 12 minutes. The exposure is daily, two times a day.EFFECT: method provides reducing the length of calculus fragments discharge following the lithotripsy procedure, improving the clinical and biochemical blood and urine statuses, renal blood flow, treating and preventing the postoperative complications, recovering the immunological responsiveness and antioxidant protection.4 dwg, 3 tbl, 2 ex
The compositon is used as a vaccine, for example anti-tumourone. It contains at least one protein, or protein (fragment) withimmunomodulating effect with adjuvant, respectovely. The peptideoriginates from a peptogenous agent of disease or a tumourantigen. The adjuvant invreases the binding between the peptideand the patient&#39;s cells and improves its penetration in them byintensifying the immunomodulation effect of the peptide. Suitableadjuvants are basic polyaminoacids such as polyarginine orpolylysine. Optionally they are conjugated with cellular ligand,e.g. carbohydrate or transferrin.33 cliams, 18 figures
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for producing a lignin derivative that exhibits an excellent antiviral action with little side effects.  &lt;P&gt;SOLUTION: The lignin derivative exhibiting an excellent antiviral action with little side effects is one that exhibits an antiviral action and has an intramolecular cyclic structure. The derivative is composed of persimmon leaf-originated lignin and, bonded thereto, hydroxyapatite and chlorine. The production method thereof comprises the steps of adding hydroxyapatite and Monascus pilosus to a powder of a persimmon leaf followed by fermentation, adding diluted hydrochloric acid to the thus-obtained fermentation liquid followed by filtration, and subsequently subjecting the thus-obtained filtrate to alkali reduction. The main steps are the fermentation step by Monascus pilosus, the hydrochloric acid addition step and the reduction step. By these steps, calcium, phosphoric acid and chlorine stably bond to lignin.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
The present invention discloses a spray drying process characterized by continuous preparation and immediate spray drying of a solution comprising at least one active pharmaceutical ingredient and/or at least one excipient, and at least one solvent. The said active pharmaceutical ingredient(s) and solvent(s) are combined, alone or along with one or more excipients to form a first suspension. Said suspension is continuously fed to an intensifier pump that pushes said suspension through at least one micro-reaction chamber and/or at least one micro-channel where the suspension&#39;s solid(s) component(s) is(are) dissolved into said solvent(s) by means of high energy mixing / forced contact at micro, nano and molecular level to form a solution stream. The said solution stream is then immediately and continuously fed to the spray dryer through at least one atomization nozzle, drying said atomized stream to obtain solid particles and collecting said solid particles. Single component particles or multi-component particles, particulate amorphous solid dispersion and pharmaceutical compositions are also disclosed. The present invention also discloses amorphous solid dispersions obtained by the method of the invention as well as pharmaceutical compositions containing the same.
The common premise of synthetic implants in the restoration of diseased tissues and organs is to use inert and solid materials. Here, a porous titanium implant enables the delivery of microencapsulated bioactive cues. Control-released TGFβ1 promoted the proliferation and migration of human mesenchymal stem cells into porous implants in vitro. Upon 4-wk implantation in the rabbit humerus, control-released TGFβ1 from porous implants significantly increased BIC by 96% and bone ingrowth by 50% over placebos. Control-released 100 ng TGFβ1 induced equivalent BIC and bone ingrowth to adsorbed 1 μg TGFβ1, suggesting that controlled release is effective at 10-fold less drug dose than adsorption. Histomorphometry, SEM and μT showed that control-released TGFβ1 enhanced bone ingrowth in the implant&#39;s pores and surface. These findings suggest that solid prostheses can be transformed into porous implants to serve as drug delivery carriers, from which control-released bioactive cues augment host tissue integration.
It is intended to provide an agent against psychosocial stresses which is highly safe and can be continuously taken, in particular, a novel agent against psychosocial stresses by which psychosocial stresses can be prevented or reduced. Namely, it is intended to provide an agent against psychosocial stresses characterized by comprising, as the active ingredient, uridylic acid, uridine or uracil.  The active ingredient, i.e., uridylic acid, uridine or uracil is available at a low cost, has a high safety because of being a biological component, and thus can be continuously taken.  Therefore, the agent against psychosocial stresses as described above is efficacious in reducing, relieving and healing psychosocial stresses that have been a serious problem in today&#39;s society.  By taking this agent prior to the onset, it is also possible to prevent psychosocial stresses.  The effects thus established are superior to the effects of GABA which attracts public attention and is widely added to foods and the like in these days.
PURPOSE:To apply a human normal osteoblastic strain to osteoporosis, renal osteodystrophia, fracture, etc., of the aged with deteriorated osteogenetic ability and enable promotion of osteogenesis by obtaining the human osteoblastic strain from a human bone tissue. CONSTITUTION:A human bone tissue, such as infant long bone, is taken out and treated with a collagenase solution to remove fibroblasts and provide human osteoblasts. A human bone tissue is then cultured in a low-calcium culture solution or further culture solution used for normal tissue culture, such as BGJb or Eagle&#39;s minimum essential medium (MEM). Cell establishment (cloning) derived from one cell is then carried out to confirm that the cells are osteoblasts by positive to staining with an alkaline phosphatase. The positive ratio is enhanced from conventional 10-30% to 50%. Thereby, osteogenesis can be accelerated by application to osteoporosis, renal osteodystrophia or fracture, etc., of the aged with deteriorated osteogenesis. In the case of especially the aged, the method is advantageous in that dementia of the bedridden aged due to fracture can be prevented.
To provide a medical skill training device that efficiently trains the skills of a responder.SOLUTION: A medical skill training device 1 is a device that performs medical skill training for training the skills of a responder who deals with a patient. A response DB 200 stores response data 210-1 to 210-n for each of inquiry item. An item selection unit 100 obtains selection results of the inquiry item and selects response data 210 of the inquiry item corresponding to the selection results stored in the response DB 200. A voice recognition unit 110 acquires a voice signal of the responder, performs voice recognition, and outputs recognition data 220. A response generation unit 120 generates the patient&#39;s response based on the response data 210 acquired by the item selection unit 100 based on the recognition data 220 voice-recognized by the voice recognition unit 110. A response output unit 130 outputs the patient&#39;s response generated by the response generation unit 120.SELECTED DRAWING: Figure 2
Solutions of anthelmintic medicines suitable for administration in an aqueous liquid are prepared by dissolving ascaridol or chenopodium oil in a salt of a basic derivative of a higher fatty acid. Substances mentioned as suitable for the purpose are the organic acid salts of diethylaminoethoxy-oleylanilide, subsubstances of the formulae &lt;FORM:0429594/VI/1&gt; &lt;FORM:0429594/VI/2&gt; and of the amidine resulting from the condensation of stearic acid imino ethyl ether hydrochloride and ethylene-diamine hydrate. Specifications 308,218, 317,325 and 339,359, [all in Class 2 (iii)], are referred to.  The Specification as open to inspection under Sect. 91 includes the preparation of anthelmintics of the class of carbon tetrachloride and ethylene tetrachloride this forming subject-matter of Specification 429,498.  It also contains references to the use of the condensation products of oleic or stearic acid with a -diethylamino-b -hydroxypropyl amine or a -diethylamino-b  hydroxy-g -phenylamino propane and of compounds described in Specifications 346,387 and 357,250.  This subject-matter does not appear in the Specification as accepted.
A novel growth factor (BTC-CG) was purified from the conditioned medium of pancreatic beta tumor cells initially derived from transgenic mice (RIP1-Tag2). The purification scheme included BioRex 70 chromatography, phenyl-Sepharose chromatography, TSL-GEL heparin FPLC and C4 reverse phase HPLC. The peptide also stimulated proliferation of bovine smooth muscle cells. It was not inactivated by boiling, by 10 mM dithiothreitol or by exposure to 1M acetic acid. Biological activity of BTC-GF was recovered from a single band of protein which had a molecular weight of 32,000 on SDS-PAGE. The partial N-terminal amino acid sequence of this protein from BTC-3 and BTC-J10 cells was determined with an ABI 470A protein sequencer to be: &lt;IMAGE&gt;
Alopecia areata is in general known as &#39;&#39;Gui ti tou&#39;&#39; in folk, namely, hair loss in pieces of areas without being felt by patients. Alopecia areata not only affects appearance, but also strikes a serious blow at self-confidence, and affects the work, life and learning. Serious alopecia areata may deteriorate into alopecia totalis (total hair loss) or even universal alopecia (total loss of hair, eyebrows, beard hair and hair all over the body). The present invention discloses an externally-applied alopecia areata-treating medicine and a preparation method thereof. People are in desperate need of an externally-applied medicine using Chinese herbal medicines as raw materials and quick in curative effect, good in effect and high in rate of cure, up to now, no any externally-applied alopecia areata-treating medicine is reported. Through years of research and clinical verification, the externally-applied alopecia areata-treating medicine is completed. The aim of the invention is to provide an externally-applied alopecia areata-treating medicine which is less in toxic side effect, effective in oil control, detoxification, solidifying hair, nourishing hair and growing hair, low in recurrence rate, good in effect, high in cure rate, and capable of treating alopecia areata in a short period of time.
Red-shifted, water-soluble, fluorescent, monomerically-tetherable derivatives having the formula: ##STR1## 
     wherein, M represents either H 2  or is selected from among the following metals: aluminum, silicon, phosphorus, gallium, germanium, cadmium, scandium, magnesium, tin, and zinc. Each R 1  is independently selected from --XYW, --YW, and --W. X represents either a carbon, or heteroatom selected from among oxygen, nitrogen, sulfur, phosphorus, silicon, and selenium; Y represents a linking group; and W represents a water solubilizing group. The substituent R 2  is selected from among --A, --Y&#39;A, --XA, and --XY&#39;A, where A denotes a biological entity such as an antibody, antibody fragment, nucleotide, nucleic acid probe, antigen, oligonucleotide, deoxynucleotide, dideoxynucleotide, avidin, streptavidin or membrane probe, or R 2  is a reactive or activatable group suitable for conjugating to a biological entity. Y&#39; is a linking group that tethers the biological entity to the phthalocyanine or tetrabenztriazaporphyrin macrocycle. Z is either a nitrogen atom or a carbon substituted with hydrogen, alkyl, aryl, or aralkyl groups. Z may also be attached to R 2 . Also disclosed are derivatives of the compounds of the above Formula in which 1-4 of the benzo ring(s) contain 1 or 2 N atoms. Methods of sequencing DNA and detecting analytes, including cells, using these derivatives are disclosed, as are kits for carrying out assays for the analytes and flow cytometry. Methods of detecting DNA using cationic compounds of the above Formula, wherein R 2  =R 1  and W=-N +  D 1  D 2  D 3  are also disclosed. Further, compounds containing Tc, Gd, etc. as the metal in the above Formula may be used for imaging or therapy.
&lt;P&gt;PROBLEM TO BE SOLVED: To partly clear the mechanism of the generation of dark circles around the eye and provide a cosmetic product to ameliorate the dark circles.  &lt;P&gt;SOLUTION: The skin care preparation to be applied mainly to the dent part under the eye contains 5-15 mass% ascorbic acid and/or its salt. The skin care preparation has uniformizing action on the skin thickness and the blood flow rate. The uniformizing action on the skin thickness and blood flow rate is recognized as the amelioration action on dark circles. The variations of the values are determined on an examinee and compared with average variations of a specimen group, and the examinee is selected as a proper person to test the preparation when the variations of the examinee are larger than the average variations.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT