anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
Deep learning-based Parkinson&#39;s Disease (PD) decision models, methods and apparatus. Mainly solves the problem that the mode of judging PD patients is not good at present. The method is characterized in that: the image processing device comprises a feature extraction module and a time sequence processing module, wherein the feature extraction module is used for extracting features from image data, the features comprise low-level features and high-level features, the low-level features comprise colors, and the high-level features comprise one or more of facial contours, eyes, nose and mouth; the time sequence processing module is used for performing time sequence processing and classification on the characteristics output by the characteristic extraction module. The invention provides a parkinsonism judgment model, a parkinsonism judgment method and parkinsonism judgment equipment based on deep learning, and designs a method for diagnosing parkinsonism hypomia symptoms by analyzing facial videos through the deep learning. Facial expression videos of PD patients and matching control groups are collected on network open source resources, and after video frame preprocessing, hypomimia is diagnosed by using a deep learning algorithm. Experimental results show that our model achieves an average accuracy of 81.73% in the classification task of Hypomimia.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a pharmacokinetic simulation device for reducing a burden on a user, and suppressing an occurrence of errors.  &lt;P&gt;SOLUTION: An arrangement means 2 is for inputting a compartment and arranging it. A type input means 4 is for inputting a type for each compartment. A term determination means 6 is for determining a term that appears in a differential equation of a drug that flows into the compartment or flows out to the compartment based on the type of each compartment. A coefficient input region display means 8 is for displaying an input region for inputting a coefficient and a flow-in source compartment or a flow-out destination compartment for each term determined by the term determination means 6. A coefficient input means 10 is for inputting a coefficient from the input region displayed by the coefficient input region display means 8. In this manner, an equation is determined by selecting a compartment type, and a user has only to input a coefficient for settings with few errors.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
PURPOSE: To measure the condition of hairs simply and quickly by immersing the hairs in a specific aqueous solution of dye, and measuring the color density of the solution. CONSTITUTION: Hairs are immersed in an aqueous solution of pH1-5 containing at least one sort of anion dye, and the change in the color density of the solution is measured ocularly. As the anion dye, a dye which develops color at a pH between 1-5 and is capable of being adsorbed to a damaged hair, for example, 1-(4-sulfo-1-phenylazo)-2-naphthol-6-sulphonic acid or its disodium salt particularly suitable for measurement of the damaged degree of the hairs after being subjected to oxidation processes frequently, is cited. The concentration of the dye in a solution to measure the acid-bonding ability of keratin fiber on the surfaces of a non-damaged hair should preferably be 10&lt;-3&gt; -10mM, while the pH of the aqueous solution of the dye be approx. 2.5. Further, adding of various solvents may heighten the measuring accuracy for the condition of dyed hairs.
A computer-implemented method of controlling operator interaction with one or more operator devices is disclosed. The one or more operator devices include one or more analysis devices configured to analyze a biological sample. The method includes, in response to any of the one or more analysis devices being triggered by an operator to perform analysis of the sample, obtaining information regarding any processing errors associated with the sample detected by the triggered analysis device in association with an identifier of the operator. The method further includes dynamically updating process error data associated with the operator&#39;s identifier based on the information about the detected process error, and controlling interaction with at least one of the one or more operator devices based on the process error data associated with the operator&#39;s identifier for the operator&#39;s identifier. A computer-implemented method of an analysis device is also disclosed. The method includes detecting any processing errors associated with the sample in response to the analysis device being triggered by an operator to perform analysis of the sample. The method further includes, in response to detecting the processing error, providing information regarding the detected processing error in association with an identifier of the operator for dynamically updating processing error data associated with the identifier of the operator. Corresponding apparatus, servers, storage devices, analysis devices, operator devices, systems and computer program products are also disclosed.
PURPOSE: To obtain a novel compound which is useful as an antimicrobial agent against diseases induced by a variety of pathogenic microorganisms including MRSA because it manifests antimicrobial action to inhibit the proliferation of these microorganisms. CONSTITUTION: A compound of the formula or its salt. This compound is obtained by aerobically culturing a microorganism belonging to Actinoplanes sp. or its mutant (FERM-P-14069) in a medium containing nutrient sources, extracting the culture mixture with a solvent and isolating it by purification. The substance BE-40665D has the following properties: appearance: yellow amorphous solid or crystals; molecular formula: C22 H21 O7 Br; mass spectrography: 477.0549 (calculated value); specific rotatory power: [α]&lt;20&gt; D=-34.0 deg. (c=0.10 in CHCl3 ); solubility: readily soluble in organic solvents such as chloroform, slightly soluble in water; discrimination between acidic, neutral and basic: neutral; color reaction: positive to sulfuric acid reaction.
NEW MATERIAL:A compound of formula 1 (R is lower alkyl, phenyl, naphthyl or phenyl bearing 1-3 substituents selected from lower alkyl, halogenated lower alkyl, lower alkoxy, nitro and cyano groups; Y is O, S; n is 2, 3) and its salt. EXAMPLE:2,3,5,6-Tetrahydro-2-(4-methylphenoxymethyl)imidazo[2,1-b]oxaz ole. USE:Local anesthetic. Or its used as a preventive or remedy for thrombosis. PREPARATION:A halide of formula 2 (X is halogen) or epoxy compound of formula 3 is made to react with a diamine of formula 4 to give a compound of formula 5. Then, the product is made to react with carbon disulfide to form a compound of formula 6. Further, an alkyl halide of formula 7 (R&#39; is halogen) is made to act on the product to give a compound of formula 8, on which a base is made to act to give the compound of formula 1.
In accordance with embodiments of the invention, a food scoring system is provided. A centralized data processing server is provided and hosts a database of nutrition information of foods and genetic testing information of a patient. The genetic testing information includes recommended consumption of macronutrients and levels of micronutrients based on the patient&#39;s genetic composition. A software application is operable for the patient to enter food consumed or food to be consumed into the application. The software application communicates with the centralized data process server. By operation of the processing server, the efficacy of the nutrition of the meal relative to the patient&#39;s recommended intake of macronutrients and micronutrients is analyzed. By operation of the processing server, a meal rating score and a micronutrient rating score are calculated based on the nutrition of the meal. The meal rating score and the micronutrient score are displayed via the software application.
A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R&lt;sup&gt;1&lt;/sup&gt;, R&lt;sup&gt;2&lt;/sup&gt; and R&lt;sup&gt;3&lt;/sup&gt; are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed. A compound of Formula I, enantiomers, diasteriomers, tautomers or pharmaceutically acceptable salts thereof, wherein R&lt;sup&gt;1&lt;/sup&gt;, R&lt;sup&gt;2&lt;/sup&gt; and R&lt;sup&gt;3&lt;/sup&gt; are defined herein, are useful as inhibitors of one or more Janus kinases. A pharmaceutical composition that includes a compound of Formula I and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient are disclosed. A compressed-air energy storage system according to embodiments of the present invention comprises a reversible mechanism to compress and expand air, one or more compressed air storage tanks, a control system, one or more heat exchangers, and, in certain embodiments of the invention, a motor-generator. The reversible air compressor-expander uses mechanical power to compress air (when it is acting as a compressor) and converts the energy stored in compressed air to mechanical power (when it is acting as an expander). In certain embodiments, the compressor-expander comprises one or more stages, each stage consisting of pressure vessel (the &#34;pressure cell&#34;) partially filled with water or other liquid. In some embodiments, the pressure vessel communicates with one or more cylinder devices to exchange air and liquid with the cylinder chamber(s) thereof. Suitable valving allows air to enter and leave the pressure cell and cylinder device, if present, under electronic control.
PURPOSE: To obtain a cosmetic capable of sufficiently exhibiting a characteristic feature of natural water to the skin and giving excellent usability on it such as soft and moist feeling after use by adjusting pH of the natural water into a specific range within a specific period after collection. CONSTITUTION: This cosmetic is produced by compounding a natural water whose pH is adjusted into 2.5-4 or 8.7-11 within 7 days, preferably within 3 days after collection. The natural water is preferably collected from the foot of Mt. Fuji, Rokkou mountain in Hyogo prefecture, etc. Further, the compounding ratio of the natural water is preferably &gt;=3wt.% for a cosmetic lotion and &gt;=2wt.% for a solid cosmetic having a stick-shape, a pencil-shape, etc., such as a lipstick based on the total amount of the cosmetic. Concretely, the adjustment of pH is performed e.g. with hydrochloric acid or NaOH adding in an amount of 0.001wt.%.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a magnetism irradiation device having biocompatibility, long-period stability and high degree of design freedom.  &lt;P&gt;SOLUTION: The magnetism irradiation device includes a magnet, a space and a sealed casing for holding the magnet in the space. The casing is made of materials that are biocompatible and are not biodegradable. Directivity may be given by applying a shield to a part of the magnet. Suitable materials for the casing include any one of titanium-based materials, ceramics, oxynium and ultrahigh-molecular-weight polyethylene or a combined material of these materials.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
A method of visualization during orthopaedic surgery. The method includes the step of a pre-operative planning step comprising displaying an initial three-dimensional image depicting anatomical features of a patient&#39;s bone. The image is retrieved by undertaking imaging or scanning of the patient&#39;s bone. The image is processed using a processor operable to carry out one or more image processing steps to generate a modified three-dimensional image. A mixed reality visualization device receives the modified three-dimensional image. The method also includes the step of displaying the modified three-dimensional image, via the mixed reality visualization device, and overlaying the modified three-dimensional image on or adjacent the anatomical features of the patient&#39;s bone to provide a visual guide to a surgeon while conducting surgery.
NEW MATERIAL:A compound formula I [A is S or O; R1 is (substituted)amino, hydrazino or 6- or 7-membered heterocyclic group containing one or more N atoms; R2 and R3 are halogen, (substituted)alkyl or aryl; m is 0-2; n is 0-4] and salts thereof. EXAMPLE:N-(2-Aminoethyl)-benzo[b]thieno[2,3-c]pyridine-3-carboamide hydrochloride. USE:A medicine and psychotropic agent having antianxiety and learning improving action. PREPARATION:For example, a compound expressed by formula II is reacted with a compound expressed by formula VIII (R4 is H or R2) to form a compound expressed by formula III, which is then reacted with a compound expressed by formula IX to afford a compound expressed by formula IV. The resultant compound expressed by formula IV is subsequently reacted with Fe and HCl to form a compound expressed by formula V, which is then reacted with a compound expressed by formula X (R4&#39; is same as R4) to provide a compound expressed by formula VI. The obtained compound expressed by formula VI is subsequently reacted with a compound expressed by the formula HX1 (X1 is leaving group, etc.) and then dehydrosulfurized with NaHCO3 and S to provide the aimed compound expressed by formula I.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a hospital information system for accurately grasping even the case of a medical practice which takes time.  &lt;P&gt;SOLUTION: A sub-system 4A provided with a non-portable PC terminal 6 for performing order registration or the like, and a PDA system 4B provided with a portable PDA 8 capable of inputting and outputting data, are connected to a hospital internal information management system 2 for managing information in a hospital, through a LAN 3. A nurse refers to a work schedule list of instillation or the like set in a work schedule, by carrying the PDA 8, and performs work of starting the scheduled instillation at the place of a patient at the bedside which is a practice place. After the practice of the work, the nurse inputs the practice which is accurately registered in a database of the hospital internal information management system 2, and this information can be rapidly obtained even at the occurrence of such a situation that the actual starting time is put off from the scheduled time. Subsequent work scheduled practices can thereby be easily coped with.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
PURPOSE:To obtain a fluorine-contained monomer useful as artificial denture base, etc., having one double bond in the molecule, by reacting a fluorine-contained multiple telomer having one hydroxyl group at the end of a molecular chain and a specific molecular weight with (meth)acrylic acid chloride. CONSTITUTION:Two or more fluorine-contained monomers (e.g., vinylidene fluoride, vinyl fluoride, etc.) and any primary tertiary alcohol as a telogen are subjected to telomerization in an alcohol, to give a fluorine-contained multiple telomer having &lt;=1,500mol.wt. and one hydroxyl group at the end of a molecular chain. The telomer is esterified with (meth)acrylic acid chloride in a solvent such as carbon tetrachloride, etc., to give the desired substance. USE:An artificial denture base, weather-resistant paint, etc.
&lt;P&gt;PROBLEM TO BE SOLVED: To resolve defects of a conventional radiological image managing system wherein information concentrates in a trunk server, such a system is expensive, communication is slow due to concentration of information and communication is usually carried out by using thinned information.  &lt;P&gt;SOLUTION: One personal computer is respectively connected to each image pickup machine, and it is connected to a telecommunication network. Sets are placed for only a number of necessary divisions. A viewing side connects to the telecommunication network and reads an image from the personal computer of a division to which one belongs, and uses the image in actual medical care. As a result, a system with high security, fast speed, superior convenience and a high medical level due to usage of un-thinned data, allowing management of data by a patient by handing over data to the patient is inexpensively constructed.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a body weight-reducing agent for a mammal, especially a weight-reducing agent for a mammal utilizing Clostridium botulinum exoenzyme C3.  &lt;P&gt;SOLUTION: By dosing a mammal with Clostridium botulinum exoenzyme C3 as a weight-reducing agent, the weight reduction of the mammal is attained without affecting the external eucrasia of all the body of the mammal. This body weight-reducing agent is used basically by oral administration and can be made into a pharmaceutical preparation by properly compounding with medicinally allowable vehicle, stabilizer, diluent, or the like. Since the effective component is protein, the agent can be made into a storable pharmaceutical preparation by the addition of the vehicle/stabilizer, the diluent, and other additives followed by freeze drying. When given to an organism, the agent is reconstituted to be used.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
PURPOSE:To obtain a solid powdery cosmetic capable imparting waterresistance and oil resistance to a cosmetic film without deteriorating the usability in wet state and dry state by compounding a fluorine-based oil, a specific polyhydric alcohol, a nonionic surfactant and cosmetic powder at specific ratios. CONSTITUTION:This solid powdery cosmetic usable in wet state as well as dry state is produced by combining 0.1-12wt.% of a fluorinebased oil of formula (R1 to R5 are F, a perfluoroalkyl or an oxyperfluoroalkyl; p to r are an integer of &gt;=0 to give a molecular weight of 500-100,000l p, q and r are not 0 at the same time), 0.1-3wt.% of a polyhydric alcohol having &gt;=2 OH groups in one molecule, 0.01-2 pts.wt. of a nonionic surfactant and powder for cosmetic use. The fluorine-based oil is e.g. Fonbrin HC-25 (product of Montefroth Co.), the polyhydric alcohol is glycerol, propylene glycol, etc., the nonionic surfactant is polyoxyethylene sorbitan monooleate, etc., and the cosmetic powder is talc, sericite, etc. The cosmetic is easily transferable to an application tool in wet state and uniformly dispersible in water.
The invention relates to medical microbiology and can be used for producing vaccine preparations. A method for preparing a conjugate Haemophilus B-type vaccine is proposed. The method comprises culturing Haemophilus influenzae B-type &#34;GKPM-Obolensk&#34; B-7884 strain in a liquid nutrient medium supplemented with ribose, inactivating the culture by heating to 55±5°С and maintaining at this temperature for 15±3 minutes, separating the biomass using a centrifuge and isolating polyribosylribitol phosphate (PRP) by precipitation with a 10% solution of cetyltrimethylammonium bromide (CTAB). The method further comprises the steps of concentration, purification, clarification, activation of PRP and mixing thereof with tetanus toxoid. The substance produced is then purified and sterilised, pharmaceutically acceptable excipients are added thereto, and it is dispensed and freeze-dried. The method provides for an increased yield of the target product.
The invention relates to a solvent used for treating Parkinson&#39;s disease. The invention belongs to the technical field of Chinese and Western medicine combined preparation. The solvent is mainly composed of 10 traditional Chinese medicines such as tall gastrodia rhizome, sharpleaf uncaria stem with hooks, salvia miltiorrhiza, Chinese quince, scorpion, lumbricus, and red berry jackinthepulpit tuber; 2 Western medicines such as musk injection and levodopa injection; and an auxiliary material which is distillate spirit. The ratio of the traditional Chinese medicine to the Western medicine to the auxiliary material is 1.2-0.5:1. The medicine liquid is an external solvent, and provides functions such as meridian dredging, wind subduing, qi benefiting, blood nourishing, refreshing, resuscitation, blood circulation activating, phlegm expelling, dopamine receptors direct exciting, and dopamine release promoting. The solvent has good treatment against Parkinson&#39;s disease, and caused no toxic or side effect. Therefore, a novel approach for treating Parkinson&#39;s disease is developed.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to pulmonology, and can be used in treatment of pneumonia. For this purpose antibacterial, anti-inflammatory, symptomatic therapy and physiotreatment are carried out. As antibiotic selected is ceftriaxone which is introduced by indirect lymphotropic therapy. In case when superior or medial lobe of lung is affected, needle is stuck on the border of mammary gland region and lateral chest region on anterior axillary line of the side of affected lung. In case when inferior lobes of lung are affected - on the border of subscapular and scapular region on scapular line on the side of affected lung. Needle is stuck subcutaneously to the depth 1.0 cm and lidase solution in dose 32 UNITS is injected. 2-3 minutes later, without removing the needle, solution of 0.5 g ceftriaxone is introduced with the following massage of the region along the course of lymphatic channel. Introduction is performed once a day. ^ EFFECT: invention allows to reduce dose of introduced antibiotic, increasing at the same time treatment efficiency due to creation in patient&#39;s lymphatic system, in direct vicinity from inflammation focus, of optimal medication concentration. ^ 2 ex
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an improved bandage for aiding a traumatotherapy process.  &lt;P&gt;SOLUTION: A composition including a bioactive peptide is disclosed. An active peptide is isolated from fragments derived from human hair keratin protein or sheep wool keratin protein. The composition is prepared for pharmaceutical or topical administration or for use in cosmetic preparations. The activity of the peptide is shown by capability of stimulating the growth of skin fibroblasts in comparison with heretofore known fibroblast growth factor. Therefore, the composition including the peptide is useful for treating the conditions including an injured organization and skin, an aged organization and skin, or a morbid organization and skin.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PURPOSE: To obtain an adhesive composition containing a polymerizable (meth) acrylate monomer, a specific coated inorganic particle and a polymerization initiator, enabling sure inspection of the restoration status in dental therapy and having excellent bonding operability and restoration effect, in the bonding of dentine and restoration material. CONSTITUTION: This adhesive composition contains (A) a polymerizable (meth) acrylic monomer, (B) X-ray contrasting coated inorganic particles produced by coating (i) 100 pts.wt. of inorganic particles with (ii) 1-10 pts.wt. of a methacrylate polymer containing &gt;=50wt.% of an acryl methacrylate unit by mechanical treatment, (C) a polymerization initiator composed preferably of a trialkylborane or its partial oxidate and preferably further (D) a conventional filler for dental use. The amounts of the components A, B and C are preferably 80-40 pts.wt., 20-60 pts.wt. and 0.01-30 pts.wt. based on 100 pts.wt. of A+B and that of the component D is preferably 5-40 pts.wt. based on 100 pts.wt. of the sum of the components A to D.