anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
A resin drug adsorbate comprises a cross-linked polystyrene/divinyl benzene nuclear sulphonic acid cation exchange resin, e.g. in micropowdered form, in which at least some of the cations, e.g. 25-38%, present are cations of amprotropine:-  &lt;FORM:0925890/IV(a)/1&gt; The adsorbate may be made by charging at 15-25 DEG C. an aq. solution of an amprotropine salt, e.g. phosphate or a water-soluble mineral acid (e.g. HCl) salt, to the resin, which may be in an alkali metal, e.g. Na, or H2 cycle, until the mixture reaches equilibrium; the mixture is then filtered and the resin dried, e.g. at 45 DEG C., and may then be ground in a mill.  An pharmaceutical adjuvant may be used in admixture with the adsorbate.  Specification 577,707 is referred to.ALSO:Pharmaceutical compositions for slow oral injestion comprise a cross-linked polystyrene/divinyl benzene nuclear sulphonic acid cationexchange resin in which at least some of the cations present are those of amprotropine having the formula &lt;FORM:0925890/VI/1&gt; Examples of compositions relate to tablets comprising the above resin/drug adsorbate alone and together with (a) an antacid composition comprising aluminium hydroxide and magnesium trisilicate and which may also comprise phenindamine tartrate; (b) an antacid composition comprising dihydroxy aluminium aminoacetate and which may also comprise phenobarbitol or acetyl salicylic acid; (c) acetyl-salicylic acid, acetophenetidin and caffeine and which may also comprise phenindamine tartrate alone and with phenylephrine hydrochloride and (d) acetophenelidin, caffeine and isopropyl-antipyrine.  Specification 577,707 is referred to.
Transparent oil-in-water emulsion with oil globules having an average size of &lt;100 nm, comprises an amphiphilic lipid phase contg. at least one non-ionic amphiphilic lipid which is liq. at &lt; 45 degrees C, the oil : lipid phase wt. ratio being 2-10. The non-ionic lipid is pref. an ester or a mixt. of esters of at least one polyol chosen from polyethylene glycol having 1-60 ethylene oxide (EO) units, sorbitan, glycerol (2-30 EO), polyglycerols (2-15 glycerol units) and at least one opt. satd. 8-22C fatty acid. The oil to lipid phase wt. ratio is 3-6. The lipid phase pref. additionally includes at least one ionic amphiphilic lipid present in an amt. of 2-10 wt.% and are chosen from e.g. alkali salts of dicetyl- and dimyristylphosphate and cholesterol sulphate or phosphate. The compsn. has a transparency of 30-90% (as determined by the transmittance coefficient measured at a wavelength of 600 nm).
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain an acetaldehyde metabolism promoting agent and medicines or food products effective for preventing and ameliorating the symptom of sick from drinking and hangover by promoting the metabolism of acetaldehyde.  &lt;P&gt;SOLUTION: The acetaldehyde metabolism promoting agent contains phytic acid and/or its salt and myo-inositol as active components. The medicine and food product effective for preventing and ameliorating the symptom of sick from drinking and hangover contain each phytic acid and/or its salt and myo-inositol as active components. The phytic acid and/or its salt can be obtained as a synthesized material or from an extract of wheat embryo, rice embryo, soybean, corn, or the like. The myo-inositol is produced by decomposing phytic acid and/or its salt.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
FIELD: molecular biology, medicine, pharmacy. SUBSTANCE: invention relates to method of specific &#34;targeting&#34; and transfer of DNA in mammalian repair cells in vivo. DNA to be transferred can include any DNA encoding the required healing protein. Repairing mammalian cells proliferate and migrate to wound region where they absorb and express DNA actively. Invention relates to also pharmaceutical compositions that can be used for transfer of required DNA. These compositions include any suitable matrix in combination with required DNA and kits. Invention provides rational method of proteins delivery which are released in the point of their action in physiological amounts required for wound healing. EFFECT: improved method of gene transfer, valuable medicinal properties. 27 cl, 8 dwg, 13 ex
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an oily thickened gel-like composition presenting extremely low skin irritancy, rich in oily component, and suitable for cleansing cosmetics, humectant cosmetics and the like, to provide a method for preparing an emulsified composition by using the oily thickened gel-like composition, to provide the emulsified composition, and to provide a cosmetic comprising the emulsified composition or the oily thickened gel-like composition.  &lt;P&gt;SOLUTION: This oily thickened gel-like composition comprises an anionic surfactant having lipopeptide structure, water and/or a polyhydric alcohol and an oily component. The emulsified composition is obtained by incorporating the above composition with water. The method for preparing the emulsified composition is provided. The cosmetic comprises the oily thickened gel-like composition or the emulsified composition.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
The invention provides traditional Chinese medicine calculus removing capsules, which are prepared from traditional Chinese medicine materials of: christina loosestrife herb, cluster mallow fruit, medicinal cyathula officinalis root, wenchow turmeric root tuber, chicken&#39;s gizzard-membrane, rhubarb, Baikal skullcap root, akabia stem, submature bitter orange, tuckahoe, largehead atractylodes rhizome, Chinese taxillus herb, Chinese thorowax root, different leaves pseudostellaria root tuber, white peony root, cattail pollen, trogopterus dung, licorice root, garden radish seed, officinal magnolia bark, nutgrass galingale rhizome, common burreed tuber, and weeping forsythia fruit. The calculus removing capsules provided by the invention has the functions of meridians warming, pain relieving, qinourishing, body fluid promoting, blood nourishing, liver nourishing, heat clearing, detoxifying, stasis removing, qi promoting, and the like. With the calculus removing capsules, calculus moving canbe promoted, and calculus can finally be discharged out of the body. Traditional Chinese medical science contains extensive disease-controlling experiences and theories of the Chinese people, handed down from thousands of years. The calculus removing capsules provided by the invention are composed of Chinese herbal medicines with the functions of inflammation resisting, toxin resisting, diuresis,cholaneresis, spleen strengthening, kidney invigorating, liver protecting, calculus degrading, and calculus removing. As a result of clinical applications, the calculus removing capsules provide unique curative effects against various calculosis.
Hair-dyestuff compsn. for the oxidation-dyeing process contains as a coupling component a deriv. of 4-hydroxy-quinolone-2 having the formula (I) (in which R is H or a 1-4C alkyl; R&#39; is H, a 1-4C alkyl; a halogen atom, OH, lower alkoxy gp., beta-hydroxyethyl or a dialkylamino gp. contg. 1-4C alkyls). The dyestuff is applied in the form of a soln., emulsion, cream or gel, wt. 15-40 degrees C. Alkaline reaction is pref. Intensive colouration in various shades is obtained; the exhaustion is very good; fast colours are produced; they may be eliminated by means of a reducing agent. The colour range is from pale blonde to dark brown, and from green to blue and violet.
The invention discloses laium domesticum flesh jelly and a production method thereof. The production method takes laium domesticum fruits as raw materials; and the following auxiliary materials are added: wallich swallowwort roots, fruits of fruitcose gomphocarpus and cymbidium pendulum stems and leaves, so that the laium domesticum flesh jelly is prepared. Nutritive values of the laium domesticum fruits are fully utilized; moreover, the laium domesticum fruits and the traditional Chinese medicines are mutually matched so as to synergistically enhance the effects; thus, the prepared laium domesticum flesh jelly has the functions of nourishing the liver, benefiting the kidney, promoting urination and eliminating the swelling. Laium domesticum juice is preliminarily fermented by using fruit-wine distiller&#39;s yeast, so that a mellow fragrance is added to the final products. Traditional Chinese medicine syrup is preliminarily fermented by using sweet-wine distiller&#39;s yeast, so that the bitter and astringent taste of the traditional Chinese medicine syrup is removed; thus, the prepared final products are aromatic, sweet and delicious in taste. The prepared laium domesticum flesh jelly is glittering and translucent in appearance as well as elastic, and has outstanding health-care functions. The laium domesticum flesh jelly is convenient to store, and is capable of obviously improving discomfort of the people with sore and pain in waist and knee caused by long-term staying in humid environment when the laium domesticum flesh jelly is taken for a long term. The laium domesticum flesh jelly is simple in preparation technology, easy to realize, vast in market, and suitable for batch production.
PROBLEM TO BE SOLVED: To simply obtain a hair rinse agent composition capable of uniformly applying to hair by combining a cationic surfactant with a specific component so that almost portion of a rinse component can be separated from a water phase when diluted with water. SOLUTION: This hair rinse agent composition is obtained by combining (A) 1-15wt.% cationic surfactant with (B) 1-20wt.% higher alcohol, (C) 30-98wt.% organic solvent soluble in water and contains &lt;=15wt.% water content. The composition is prepared so that &gt;=98wt.% rinse component is separated from water phase, when the composition is diluted into &gt;=1.8 times by water. Further, an oily component which is insoluble to water or slightly soluble to water may be added to the system. A compound of formula I or II [R&lt;1&gt; is an alkyl, etc.; R&lt;2&gt; is H, methyl, etc.; R&lt;3&gt; and R&lt;4&gt; are H, methyl or ethyl; R&lt;5&gt; is an alkylene; A is a halogen or an organic anion; (n) is 1-10] is used as the component A. The rinse agent composition has high rinse effect and is excellent in feeling to users and persistency of effect.
In alternative embodiments, probiotic formulations for the treatment and alleviation of metabolic and oxidative stress, inflammation and neurodegeneration and methods of using the same, including compositions, formulations, articles of manufacture and kits comprising the same, are provided. In alternative embodiments, the probiotic formulation as provided herein comprises or consists of: any combination of Lactobacillus fermentum (Lactobacillus fermentum) NCIMB 5221, Lactobacillus plantarum (Lactobacillus plantarum) NCIMB8826, and bifidobacterium longum infantis (bifidobacterium longum spp. infarnatum) NCIMB 702255. In an alternative embodiment, the probiotic formulation as provided herein is combined with a sanguobao. In alternative embodiments, the probiotic formulations as provided herein are used to treat metabolic diseases such as diabetes and obesity, inflammatory diseases such as IBD, IBS, arthritis; and neurodegenerative diseases such as alzheimer&#39;s disease and parkinson&#39;s disease. In alternative embodiments, the probiotic formulations provided herein are used to combat oxidative stress, reduce inflammation, lower blood and total glucose levels, lower triglyceride levels, and manage insulin resistance.
Dentyme, will be a simple web application developed using a web framework such as Ruby on Rails or NodeJS. This application will be accessible from any modern Internet browser and will feature SSL encryption. Dentyme will be leveraging dental fee guides across various provinces as a standard for what the appropriate allotment of time for various dental services should be. Fee guide data will be stored in the application&#39;s database and can be updated as rates change each year. Inputted data will be analyzed to provide the service provider with reports on their individual performances, whether or not they have met the standard of time allotted for specific services applicable to their industry. The application will also report on the revenue lost due to mismanagement of time when providing services.
The onset of Parkinson&#39;s disease (PD) is a serious concern for elderly people and it is necessary to identify the risk for PD in an individual as early as possible. A system and method for risk assessment of an individual for Parkinson&#39;s disease (PD) has been provided. The system is using a non-invasive method for risk assessment of PD through prediction of metabolic potential of the bacteria residing in gastrointestinal tract of the individual. The system 100 is configured to calculate a score, which is evaluated from the gut bacterial taxonomic abundance profile, which is indicative of its metabolic potential for production of a particular neuroactive compound. This score is subsequently used to assess the risk of an individual of being affected by PD. Further, the present disclosure also provides microbiome based therapeutic approaches that can potentially minimize the side effects through maintaining the healthy cohort of bacteria in gut.
PURPOSE:To provide a hemocathartic agent composed of an emulsion of a perfluorocarbon compound used as an oxygen-carrier transfusion, and capable of effectively cleaning the blood containing toxic substances. CONSTITUTION:The objective hemocathartic agent is composed of a perfluorocarbon compound emulsion obtained by emulsifying a perfluorocarbon compound such as perfluorocylcoalkane, perfluoroalkylcycloalkane, perfluoro-N-methyl perhydroquinoline, etc. to a particle size of &lt;=0.3mu using a polymeric nonionic surface active agent (e.g. polyoxyethylene-polyoxypropylene copolymer) and/or a phospholipid (e.g. egg yolk phospholipid) as an emulsifier and a 8-22C fatty acid compound (e.g. caprylic acid) as an assistant for emulsification. The hemocathartic agent can be applied to the diseases such as hepatic insufficiency, icterus gravis, incompatibility of the blood group in transfusion, drug intoxication, etc. The blood contaminated by intoxication, etc. is released from the body, and at the same time, the perfluoro compound emulsion is infused in the vessel.
The invention relates to a pharmaceutical composition for treating Hashimoto&#39;s thyroiditis and a preparation method thereof. The pharmaceutical composition is composed of bupleurum, radix curcumae, prunella vulgaris, rhizoma Dioscoreae Nipponicae, thunberg fritillary bulb, radix scrophulariae, edible tulip, astragalus, dark plum and other components, and can be made into granules, capsules, tablets or pills by the conventional pharmaceutical processes. The pharmaceutical composition has the effects of soothing liver-qi stagnation, reducing phlegm, removing stasis, and softening hardness to dissipate stagnation, and applies to patients with Hashimoto&#39;s thyroiditis and thyroid nodules. Clinical studies have shown that the pharmaceutical composition can significantly improve the symptoms of Hashimoto&#39;s thyroiditis, reduce the thyroid volume and isthmus thickness, and reduce the level of TgAb and TPOAb, and the total effective rate is 97.22%. In addition, for patients with thyroid nodules, nodules can be significantly reduced or even disappeare, no significant adverse reactions are presented in the course of treatment. Experimental studies have shown that the pharmaceutical composition reduces the level of TgAb and TPOAb, and reduces inflammatory infiltration and thyroid follicular damage.
Formulations for promoting hair growth, preventing or mitigating hair loss, or enhancing skincare include a GHK peptide and a fullerene, such as C60, that has been processed to be safe for human consumption. In examples, the fullerene includes ESS60. In examples, the GHK peptide includes a GHK-Cu peptide, such as UTH29. Such therapeutic formulations may be applied to a person&#39;s skin or hair. In some embodiments, the peptide is dissolved in a polar solvent. In some embodiments, the fullerene is dissolved in a lipid solution. The formulations, when administered topically or introduced into the top layers of the epidermis, are effective in preventing or mitigating hair loss and graying that arises from age or elevated DHT levels. The formulations are also effective for use in the lightening of skin blemishes and prevention or mitigation of certain skin cancers that arise from age and UV damage.
PCT No. PCT/EP93/01774 Sec. 371 Date Feb. 21, 1995 Sec. 102(e) Date Feb. 21, 1995 PCT Filed Jul. 3, 1993 PCT Pub. No. WO94/01436 PCT Pub. Date Jan. 20, 1994The invention provides compounds of formula I    &lt;IMAGE&gt;  I  and pharmaceutically acceptable salts thereof; wherein R50 is hydrogen or C1-4 alkyl, A51 is oxygen, sulphur or a group of the formula -NR52- wherein R52 is hydrogen or C1-4 alkyl; A50 comprises i) a mono or bicyclic aromatic ring optionally containing one or more nitrogen, oxygen or sulphur atoms, ii) a cycloalkendiyl group, or iii) an acyclic bridging group having a chain of one, two or three atoms between the cyclobutenedione group and X50, said chain being a chain of one or two carbon atoms or a chain of one carbon atom and one or more nitrogen, oxygen or sulphur atoms or iv) a bond; X50 is either a bond or a spacer group providing a chain between A50 and B50 of one or two atoms length; B50 is a mono or bicyclic aromatic-ring optionally containing one or more nitrogen, oxygen or sulphur atoms; r is an integer from 1 to 6; and Het is a ring system optionally containing one or more nitrogen, oxygen or sulphur atoms or is a phosphonate, phosphinate or amine derivative (wherein each of A50, X50, B50 and Her are optionally substituted). The compounds have angiotensin II antagonist activity and are useful in the treatment of cardiovascular disorders such as hypertension.
PURPOSE:Separately dried burdock (Arctium lappa L.) and potatoes are powdered and mixed at a specific ratio to give the medicine that can cure stomach cancer by taking after meals. CONSTITUTION:60% of dried burdock powder and 40% of dried potato powder are mixed to give the medicine able to cure stomach cancer. When it is taken after meal in an amount of teaspoon full, stomach cancer is cured. Inventor&#39;s mother told him when he was a child that stomach cancer can be cured by taking a powder of raw burdock seeds three times a day after meal and the inventor tried it on several persons and they were relieved really without surgery. Since publication of this kind is legislatively restricted in Japan (by newspaper, ministry of Public Welfare, University Hospitals, etc.), the inventor has announced it in the form of an invention.
PURPOSE:To provide the title material easy in mass production, usable in various fields, consisting of granules each of which is made up of porous skin of water-insoluble matter and a single nearly spherical hollow space. CONSTITUTION:The surface of a core material consisting of a water-soluble matter (e.g. saccharide, organic acid, inorganic salt) is coated with water- insoluble film followed by dissolving out the core material with water, thus giving the objective hollow material having the following characteristics; (1) average diameter: &gt;=0.1 (pref. 0.1 - 4, esp. 0.5 - 1.5) mm; (2) made up of water- insoluble skin and a hollow space, being nearly spherical as a whole; (3) said hollow space is a single and nearly spherical; (4) the skin is porous; (5) when plunged into water with no agitation, being suspended for at least 24 hr; and (6) if its mean size is &lt;= 4 mm, its suspendability remains even if tableted together with other shaping agent. By providing the surface of the present material with a useful substance, a product suspendable in a liquid can be obtained.
&lt;P&gt;PROBLEM TO BE SOLVED: To allow a medical doctor to intuitively grasp the consultation history of a patient.  &lt;P&gt;SOLUTION: A history information storage part 182 stores history information including a patient ID; a clinical department of the patient; and clinical date specifying information which indicates a clinical date in the clinical department of the patient in a prescribed period, which is specified by the patient ID. A display color storage part 1831 stores the display color of each clinical department and the display color of non-clinical date. When a consultation history display request including the patient ID is transmitted from a terminal apparatus, a consultation history display data generating means 15 generates consultation history display data for displaying a consultation history display graph, based on the history information of the applicable patient stored in the history information storage part 182 and the content of the display color storage part 1831. The consultation history display graph is a band graph for the portion of the prescribed period with one day as a unit length, where an area corresponding to the clinical date is made to be the display color corresponding to the department of a clinical examination performed on the day.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
NEW MATERIAL:The compound of formula I (R is OH bonded in the form of exo or endo). EXAMPLE:3-Exo-hydroxy-endo-tricyclo[6.2.1.0&lt;2.7&gt;]undecane. USE:A perfume component of a perfumery composition having strong fragrance. The compound of formula II has menthol-like and the compound of formula IIIhas woody and camphor-like fragrance mixed with slight patchouli-like flavor, and is useful for the flavoring of lavender-type perfumery. Since the compound has a polycyclic aliphatic structure similar to natural sesquiterpene alcohols, the compound is expected to have pharmacological activities such as antiviral, antibacterial and plant-hormone activities. PREPARATION:The compound of formula I wherein R is OH bonded in exo-form (the compound of formula II) is produced by dehydrating 2-exo-hydroxy-endo- tricyclo[6.2.1.0&lt;2.7&gt;]undecane of formula IV, and hydroborating the product with B2H6 and H2O2.
PROBLEM TO BE SOLVED: To improve the dispersibility and preservable stability at the time of well dispersing the inorg. particulates to be used for a UV shielding agent into an aq. medium by preparing a dispersant from saccharose fatty acid ester having an HLB and carbon atoms of constituting fatty acid of specific values. SOLUTION: The dispersant used at the time of preparing the inorg. particle dispersion for UV shielding used for cosmetics, medicaments, coating materials, etc., for preventing UV rays is prepd. by using the saccarose fatty acid ester having the HLB of &gt;=10 and the carbon atoms of the constituting fatty acid of &lt;=16 and adding an anionic surfactant thereto at need. The examples of the anionic surfactant include a fatty acid salt, fatty acid ester lactate salt, monoglyceride citrate, monoglyceride succinate, diacetyl monoglyceride tartrate, stearyl ester sodium fumarate, etc. Titanium oxide, etc., are used as the inorg. particle for UV shielding and are preferably the particulates subjected to a hydrophilicity impartation treatment an their surfaces.