anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PURPOSE:To widen a treatment range and to improve a treatment effect by integrally molding germanium and ceramics which radiates far IR rays by heating. CONSTITUTION:The molding for cutaneous contact treatment is formed by integrally molding the germanium and the ceramics. The integrally molded material exemplified by the molding formed by molding a mixture composed of the uniformly mixed germanium and the ceramics in the form of powder, the molding formed by discretely molding the germanium and the ceramics and integrally joining the moldings, etc. The germanium having &gt;=99.9% purity is preferable as the inorg. germanium. The far IR radiative ceramics is formed by mixing the fine powders or fine calcined powders of ZrO2, MgO, Al2O3, SiO3, Cr2O3, TiO2, and Fe2O3 alone or in adequate combination and sintering the mixture at need. The molding 1 is adhered to the center of a round shaped adhesive plaster 5 in the state of pressing the sticking side of aluminum foil 3 to the center in such a manner that the cutaneous contact surface 4 of this molding 1 comes into contact with the ill part of the &#39;Tsubo&#39; (an effective spot for applying moxa), etc. This adhesive plaster 5 is used by sticking the adhesive plaster to the body.
PROBLEM TO BE SOLVED: To obtain a stable, easily administrable medicinal preparation containing a specific protein, having factor VIII coagulation promoting activity and vWF binding activity, mitigating burden on patients involved because of long half-life, and useful for e.g. homophilia. SOLUTION: This medicinal preparation contains a protein having factor VIII coagulation promoting activity and vWF binding activity. The protein has an amino acid sequence derived from the amino acid sequence of a factor VIII protein and containing at least one mutation in at least one immunodominant domain such as C2- and/or A2-domain of the factor VIII. This protein exhibits factor VIII coagulation promoting activity &gt;=30%, pref. &gt;=50%, more pref. &gt;=80%, esp. pref. &gt;=100% higher than that of a mutation-free factor VIII protein.
The invention provides a method and materials for sorting polynucleotides with oligonucleotide tags. Oligonucleotide tags of the invention are capable of hybridizing to complementary oligomeric compounds consisting of subunits having enhanced binding strength and specificity as compared to natural oligonucleotides. Such complementary oligomeric compounds are referred to herein as &#34;tag complements.&#34; Subunits of tag complements may consist of monomers of non-natural nucleotide analogs, referred to herein as &#34;antisense monomers&#34; or they may comprise oligomers having lengths in the range of 3 to 6 nucleotides or analogs thereof, including antisense monomers, the oligomers being selected from a minimally cross-hybridizing set. In such a set, a duplex made up of an oligomer of the set and the complement of any other oligomer of the set contains at least two mismatches. Preferred antisense monomers include peptide nucleic acid monomers and nucleoside phosphoramidates having a 3&#39;-NHP(O)(O-)O-5&#39; linkage with its adjacent nucleoside. An important aspect of the invention is the use of the oligonucleotide tags for sorting polynucleotides by specifically hybridizing tags attached to the polynucleotides to their complements on solid phase supports. This embodiment provides a readily automated system for manipulating and sorting polynucleotides, particularly useful in large-scale parallel operations, such as large-scale DNA sequencing, mRNA fingerprinting, or the like, wherein many target polynucleotides or many segments of a single target polynucleotide are sequenced simultaneously.
PROBLEM TO BE SOLVED: To obtain a compound useful for producing a composition excellent in waving effects and persistence, low damaging properties to damaged hair, blending and low odor properties and safety when used as a reducing agent for a permanent waving composition. SOLUTION: This polyalkylene glycol monothiolactate of formula I [R&lt;1&gt; is ethylene or propylene; (n) is an integer of 2-4], e.g. diethylene glycol monothiolactate. The compound of formula I is obtained by reacting 1mol equiv. thiolactic acid or alkyl thiolactate of formula II (R&lt;2&gt; is H or a 1-4C alkyl) with preferably 1.5-3mol equiv. polyalkylene glycol of formula III at 80-180 deg.C. Water produced at this time is preferably removed. Furthermore, the compound of formula I as a reducing agent in a blended amount of 5-30% is mixed in an aqueous medium and the pH is preferably regulated to 6.5-8 to afford an excellent permanent waving composition.
PROBLEM TO BE SOLVED: To obtain the subject synthetic suppressant capable of suppressing the synthesis of heat shock protein in cells and curing diseases such as cancer and multiple sclerosis by containing a specific aloin derivative as an active ingredient. SOLUTION: This synthetic suppressant contains an aloin derivative of formula I (R&lt;1&gt; is a hexose residue excluding a hydroxy group at the 1-position of hexose; R&lt;2&gt; is a 1-3 C hydroxyalkyl). As this aloin derivative, aloin of formula II is preferable. Aloin is contained in a crude drug such as aloe and the like and obtained by extracting e.g. aloe with water (e.g. cold water, warm water or boiling water) or an organic solvent. By this suppressant, cancers relating to the change of normal cells to malignant tumors and the reduce of effect in the thermotherapy and autoimmune diseases such as multiple sclerosis and the like relating to the occurrence caused by heat shock protein from 16kDa to 40kDa in molecular weight can be effectively cured.
An anti-inflammatory substance is isolated from grape seeds by extn. with a mixture of &gt;=2 mutually miscible, plar organic solvents, to give a substance having an anti-inflammatory value 5. The anti-inflammatory value is the minimum quantity given orally in h/kg body weight, which causes a statistically significant decreases in carrageenin-induced oedema in rats. Typical solvent mixtures are of chloroform, methanol and opt. acetone, pref. as azeotropes. In an example, crushed grape seeds were extracted for 8 hours. At 53.5 degrees C with an aeotropic mixture of 87 pts. chloroform and 13 pts. of methanol. The solvent was evaporated and the residue had an anti-inflammatory value of 1.25.
Systems, methods, and computer program products that enable system-wide probabilistic forecasting, alerting, optimizing and activating resources in the delivery of care to address both immediate (near real-time) conditions as well as probabilistic forecasted operational states of the system over an interval that is selectable from the current time to minutes, hours and coming days or weeks ahead are provided. There are multiple probabilistic future states that are implemented in these different time intervals and these may be implemented concurrently for an instant in time control, near term, and long term. Those forecasts along with their optimized control of hospital capacity may be independently calculated and optimized, such as for a dynamic workflow direction over the next hour and also a patient&#39;s stay over a period of days. In the present application, a probabilistic and conditional workflow reasoning system enabling complex team-based decisions that improve capacity, satisfaction, and safety is provided. A means to consume user(s) judgment, implement control on specific resource assignments and tasks in a clinical workflow is enabled, as is the dynamical and optimal control of the other care delivery assets being managed by the system so as to more probably achieve operating criteria such as throughput, waiting and schedule risk. InI 0 cm 6. ra E (EN (0 7:
Carboxylic acid derivatives of the formula  &lt;IMAGE&gt;  R1 is alkoxy, alkylthio, alkylsulphinyl, alkulsulphonyl, alkylamino, cycloalkyl, or cycloalkoxy or optionally substituted aryl, aryloxy, arylthio, arylsulphinyl, arylsulphonyl or arylamino. R2 is optionally substituted aryl or, when B is alkylene also a hydrogen atom. A is a straight-chained or branched, saturated or unsaturated alkylene containing 3 to 10 carbon atoms which is optionally interrupted by a heteratom attached to a saturated carbon and has a chain length of at least 3 atoms. Y is S(O)n group or oxygen, n being 0, 1 or 2. B is a valency bond or a straight-chained or branched, saturated or unsaturated alkylene containing 1 to 18 carbon atoms. Physiologically acceptable salts, esters and amides thereof are also included. The compounds are useful in the treatment of metabolic diseases.
The cosmetic cotton pad for cleaning and peeling of skin, includes a fiber layer (2) having thermally-solidified synthetic fibers and a particle-free abrasive binder (7) connected with the fiber layer to one of its exterior surface (3, 4) that exhibits a subzone with the abrasive binder and a further subzone free of the abrasive binder. The abrasive binder is arranged along a circular, waveline-shaped, triangular, scale-shaped, straight, intersecting lines, courses, a logo, a special label and/or ornamentation. The cosmetic cotton pad for cleaning and peeling of skin, includes a fiber layer (2) having thermally-solidified synthetic fibers and a particle-free abrasive binder (7) connected with the fiber layer to one of its exterior surface (3, 4) that exhibits a subzone with the abrasive binder and a further subzone free of the abrasive binder. The abrasive binder is arranged along a circular, waveline-shaped, triangular, scale-shaped, straight, intersecting lines, courses, a logo, a special label and/or ornamentation, is applied by pressure- and/or spray- and/or foam application process and is structured at the surface. The abrasive binder exhibits a color that is different from that of the fiber layer. The abrasive binder is applied as an aqueous emulsion or dispensation of polymer droplets or particles. The abrasive binder contains peeling bodies and/or active substances. The abrasive binder penetrates into the entire depth of the fiber layer and into the superficially-lying regions of the fiber layer. The cotton pad exhibits a weight per unit area of 220-250 g/m 2&gt;. The abrasive binder exhibits a weight per unit area of 5-10 g/m 2&gt; and covers 10-30% of the exterior surface.
PURPOSE: To obtain a synthetic resin matrix system comprising a specific polymer, an organic solvent and a plasticizer, compounded with a cure-promoting medicine, and useful for storing the medicinal substance or releasing the medicinal substance for a long period. CONSTITUTION: This synthetic resin matrix system is obtained by compounding a matrix comprising a particulate, hydrophilic and water-swelling polymer [e.g. a hydroxy(2-4C alkyl) methacrylate polymer], an inactive nontoxic water- immiscible organic solvent (e.g. polyethylene glycol) and a hydrogen-bound plasticizer (e.g. dimethyl sulfoxide) with an epithelial cell growth factor or a cure-promoting medicine together with a treating article component. The matrix system comprises 15-50wt.% of the polymer, 30-65wt.% of the solvent and &lt;=20wt.% of the plasticizer. The matrix system is molded between a pair of transparent backing sheets to give a wound-treating article.
A respiratory or surgical humidifier having communication capabilities for communicating with other medical devices. The humidifier can obtain updates from the other medical devices and transmit and receive other data using the communication capabilities. The humidifier&#39;s operational state can be logged and its health can be assessed by another device. The humidifier&#39;s operation can be controlled based on data communicated from other medical devices. Also disclosed are other medical devices for communicating with the humidifier. Also disclosed are methods by which devices of a humidification and ventilation system can authenticate each other.
The invention describes the method allowing for efficient predictive ranking of clinical efficiencies of the existing targeted medicinal products for individual patient with proliferative or oncology disease. The method makes it possible to use a wide range of experimental data received from the patients&#39; pathological tissue samples and relevant control samples: information on gene mutations, transcription factor binding profile, protein (considering harmonization), mRNA (considering harmonization) and microRNA expression strength. The method also uses information on molecular targets of the medicinal products. This method can be automated to prevent potential errors associated with manual calculation and makes it possible to consider patient-specific changes in hundreds and thousands molecular pathways which include tens and hundreds of gene products. This method also considers the features and mode of action of various classes of target drugs. Using this method will enable selecting a medicinal product for the patient based on the analysis of objective individual changes occurred in the pathological tissue.
The invention relates to a Chinese medicinal powder for preventing and treating poultry diarrhea. The Chinese medicinal powder is composed of the following traditional Chinese medicines by weight: 2-3 parts of plantain seeds, 2-3 parts of radix bupleuri, 2-3 parts of radix puerariae, 2-3 parts of honeysuckle, 2-3 parts of coptis chinensis, and 1-2 parts of chicken&#39;s gizzard-membrane. The traditional Chinese medicines can be ground into a powder for use. And the Chinese medicinal powder accounts for 0.5-5% of the weight of poultry feed. The Chinese medicinal powder provided by the invention adopts cheap and easily available raw materials, is convenient to use, and can effectively reach the purpose of preventing and treating poultry diarrhea only by adding of the powder into daily feed of poultry. Also, the Chinese medicinal powder is safe and has no side effect.
The present invention relates to health food, particularly to a female cigarette type vanilla smoking product. The present invention uses ginkgo leaves, pyrola, etc., as main materials, and argyi leaves, loquat leaves, honeysuckle flowers, glycyrrhiza, etc., are added. A female cigarette type smoking product is designed according to female characteristics. The present invention has the advantages that the taste is clean, mellow and comfortable, and the aftertaste is clean and comfortable. When the present invention is always smoked, the present invention has the functions of relieving a cough, eliminating sputum, sterilizing, resisting viruses and restoring consciousness, and has the functions of preventing respiratory tracts and middle and old aged people&#39;s common disease symptoms. The epithelial cell regeneration can be promoted, the growing mechanism is maintained and promoted, and the present invention has the functions of promoting blood circulation, restoring menstrual flow, promoting urination, removing edema, etc. The effect of the present invention is obvious in the ways of regulating female irregular menstruation, dysmenorrhea, amenorrhea, persistent lochia, leukorrhagia, urinary tract infection, etc., and simultaneously, the present invention has the functions of skin beautification and senility delay.
NEW MATERIAL:A monoclonal antibody having specific reactivity to CD2 antigen of mouse or an active fragment of said monoclonal antibody. USE:A reagent for the investigation of the physiological function of mouse CD2. PREPARATION:For example, thymus is extracted from a BALB/c mouse and the thymus cell is isolated from the coating and mixed with complete Freund&#39;s adjuvant. The mixture is injected into the skin of a rat to effect the immunization of the rat. The spleen is extracted after the final immunization to obtain an antibody-producing cell. The cell is fused with a mouse myeloma cell and cultured in HAT medium to obtain a hybridoma. The hybridoma is screened to select a clone producing an antibody having specific activity against mouse CD2 antigen and the clone is monoclonized by cloning with limiting dilution analysis, etc., and cultured to obtain the objective monoclonal antibody.
PROBLEM TO BE SOLVED: To produce a nucleated granule, having a high granule strength and excellent in disintegrating properties by coating the granule with a spraying agent prepared by formulating a principal agent other than a benzimidazole- based medicine with a specific amount of a low-substitution degree hydroxypropyl cellulose. SOLUTION: This nucleated granule is obtained by coating the nucleated granule [e.g. Nonpareil (R) prepared by coating sucrose with corn starch and a spherical nucleated granule, using a crystalline cellulose and having 14-80 mesh average particle size] with a powdery spraying agent (having about &lt;=100 μm, preferably about &lt;=50 μm particle size) prepared by formulating a principal agent other than a benzimidazole-based medicine [preferably formulated in an amount of about 2-70 wt.% based on the spraying agent] with a low- substitution degree hydroxyopropyl cellulose (e.g. the one having about 4-20 wt.% hydroxypropoxyl group content and &lt;=200 μm average particle diameter) in an amount of 10-60% (wt./wt.) based on the powdery spraying agent while spraying an aqueous binder (e.g. a 0.1-80 wt./vol.% aqueous solution of a granulated sugar) thereon.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a new therapeutic system of heart disease and heart disorder, based on an entirely new concept taking the place of heart transplantation and an assistant system by medical equipment, especially a fundamental therapeutic method corresponding to intractable heart disease the fundamental therapeutic method of which is absolutely or substantially not present.  &lt;P&gt;SOLUTION: The composition and kit for regenerating the tissue of an organ of an organism and for treating disease are provided. The composition includes a cell bioactive substance and a cell in a shape suitable for importation to the heart. The kit has the cell bioactive substance, the cell and an instruction sheet. The method for regenerating the tissue of the organ of the organism, and the method for treating the disease are also provided. The method comprises a step of providing the cell bioactive substance and a step of providing the cell. As a result, the damaged tissue of the organ of the organism can be regenerated absolutely without using the organ transplantation and the assistant system by the medical equipment. Therefore, the intractable disease such as myocardial infarction and distention miocardiopathy can be treated by utilizing the invention.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a system for cooling and a method for producing a hot-filled softgel capsule.  &lt;P&gt;SOLUTION: The system for producing the hot-filled softgel capsule utilizes a chilled liquid. The chilled liquid is sent through a chilled liquid conveyor tray to a chilled liquid tank. The chilled liquid conveyor tray sets the direction of chilled liquid toward a chilled liquid layer that is flowing. The softgel capsule comprising heated and charged material is deposited in the cooling liquid layer that is flowing. The layer of chilled liquid cools the capsule by transmitting heat from the capsule to the chilled liquid. The chilled liquid layer that is flowing transfers the capsule out of the chilled liquid conveyor tray into the chilled liquid tank. A capsule carrying conveyor carries the capsule to a chilled liquid removing device out of the chilled liquid tank. The chilled liquid removing device removes the chilled liquid from the capsule.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
A Physician Study Manager may be a centralized or de-centralized data management system for medical industries, such as the sleep medicine and wellness industry. The manager may be administered by a web portal and offered as a software service. Data may be collected from relevant stakeholders of the sleep medicine and wellness industries in coordination with capable medical diagnostic equipment. The manager may improve medical care coordination by automating the workflow of medical processes in addition to improving a patient&#39;s treatment through streamlined data visualization and processing, record retainage, and diagnostic reporting. The manager may manage the needs of everyone involved in the diagnosis, treatment, and care of sleep related conditions by providing access to patient information. Users may generate diagnostic and therapy reports, and transmit them to external entities, such as insurance or medical equipment providers, directly from the manager. The software may feature electronic security measures.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a crude medicine for feed addition specialized for every classification of baby pigs, male pigs and female pigs.  &lt;P&gt;SOLUTION: The crude medicine for feed addition for baby pigs comprises dried leaves of Lycium chinense Miller, malt and dried leaves of Eriobotrya japonica Lindley as essential components. The crude medicine for feed addition for male pigs comprises dried root of Panax ginseng, dried leaves of Lycium chinense Miller, steamed rhizome of Polygonatum falcatum or Polygonatumsibiricum Redoute and dried rhizome of Dioscorea japonica Thunberg or Dioscorea batatas Decaisne as essential components. The crude medicine for feed addition for female pigs comprises dried root of Panax ginseng, dried root of Taraxacum officinale Weber, dried fruit of Zizyphus jujuba Miller var. inermis Rehder, dried rhizome of Dioscorea japonica Thunberg or Dioscorea batatas Decaisne and dried terrestrial part of Stellaria neglecta Weihe as essential components.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for producing a mucopolysaccharide in a short time at a low cost as possible.  &lt;P&gt;SOLUTION: The mucopolysaccharide is produced by degreasing, deodorizing, decoloring, filtering and drying an aqueous solution obtained by subjecting cartilages of fish to an enzymic treatment or an alkaline treatment. In other aspect, the mucopolysaccharide is produced by subjecting the aqueous solution obtained by pressurizing the cartilages of the fish to an enzymic treatment, and degreasing, deodorizing, decoloring, filtering and drying the treated product. As a result, the mucopolysaccharide such as chondroitin sulfuric acid can be produced in a short time at a low cost. The produced mucopolysaccharide can be utilized as, for example, a raw material for cosmetics, and a food material.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
A device for separating whole blood into blood components having a collecting container for collecting whole blood, a primary container, and one or a plurality of satellite containers downstream from the primary container. The collecting container is connected to the primary container via a branch line containing a leucocyte filter. In addition, provision is made for a bypass line between the collecting container and the primary container for creating a fluid connection, circumventing the filter. The primary container is, furthermore, connected, via an additive line, to an additive container containing an additive agent for storing a blood component. For extracting leucocyte-free erythrocyte concentrate, the donor&#39;s whole blood, collected in the collecting container is first conveyed, via the bypass line into the primary container. The whole blood located in the primary container is then separated by centrifuging into an erythrocyte layer and a mixed layer of blood plasma and thrombocytes. The mixed layer of blood plasma and thrombocytes is then conveyed from the primary container into the first satellite container. Subsequently, the erythrocytes resuspended in the additive agent are conveyed from the primary container, via the line path which contains the leucocyte filter, into the collecting chamber.