anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a hair cosmetic excellent in humectant effects or treatment effects on hair and having excellent treating effects and high safety. SOLUTION: This hair cosmetic is obtained by respectively formulating a hair treating composition comprising deep sea water and a water-soluble partially deacetylated chitin with a cleaning ingredient, a hair growth ingredient, a hair color agent, a perming agent and a hairdressing ingredient. The amounts of the respective formulated ingredients based on 100 pts.wt. of the hair treating composition are 1-100 pts.wt. in the case of the cleaning ingredient, hair color agent, perming agent and hairdressing ingredient and 0.01-30 pts.wt. in the case of the hair growth agent. The degree of deacetylation of the water-soluble partially deacetylated chitin is preferably &gt;=20% and &lt;40%.
Methods and compositions are provided for the treatment of Parkinson&#39;s Disease. Aspects of the methods include administering Mirol reducer. Also provided are reagents and kits for practicing the subject methods. In some embodiments, a method is provided for reducing undesirable levels of Mirol in a cell having depolarized or otherwise damaged mitochondria. In some embodiments the cell is in vivo, e.g. in an animal model for PD, in an individual diagnosed with PD, in a clinical trial for treatment of PD, and the like.
Blood cholesterol levels are correlated with production of amyloid B protein (AB), and risk of developing AD. Increasing HDL-cholesterol levels, HDL-apoA-I levels, or HDL function, decrease production of AB. Compounds which function as HDL include synthetic HDL which contains lipid such as phosphatidyl choline, phosphatidyl serine, phosphatidyl ethanolamine. Compounds which enhance HDL function include HDL associated proteins such as apo A1 or variants, reverse lipid transport peptides, apoE, enzymes associated with HDL such as paraoxonase, and LCAT, preferably, formulated in combination with liposomes or emulsions. These compositions can also be administered with compounds that increase HDL levels specifically, and thereby improve the HDL cholesterol to total cholesterol ratio or the apoA-I to total cholesterol ratio, and/or with compositions which are effective to improve the HDL or apoA-I to total blood cholesterol levels. Alternatively, cholesteryl ester transfer protein inhibitors can be used to treat Alzheimer&#39;s.
A process and resulting product for producing large unilamellar phosphatidylserine vesicles (LUV) in the diameter of about 2,000-12,000 A which may additionally encapsulate a drug. The large vesicles are prepared from an initial phosphatidylserine aqueous solution which is subjected to ultrasound or sonicated which produces small unilamellar vesicles (SUV) in the diameter range of 200-500 A. After the addition of calcium ion (Ca 2+ ) in the molar concentration of about 1-10 mM (threshold 1-2 mM) and incubating for 30-60 minutes at room temperature above 10° C and preferably 37° C, intermediate cochleate lipid cylinders form. Finally, addition of a calcium chelating agent such as EDTA or EGTA to these cochleate cylinders produces by fusion the desired large closed spherical unilamellar vesicles (LUV). The intermediate cochleate form appears specific to the phospholipid serine utilized and to the calcium ion (Ca 2+ ) incubating agent. Specific examples of drugs encapsulated in the phosphatidylserine LUV vesicles are Actinomycin D, cyclic 3&#39;5&#39;-adenosine monophosphate, Poly I Poly C, RNA, DNA, and arabinose cytocine and its phosphorylated analogs.
ABSTRACT OF THE DISCLOSURE This application relates to hair spray compositions having improved holding ability and feel when sprayed onto the hair.  Thus the present specification discloses two different specific resin combinations providing a complete  range of advantageous properties.          These specific resin combinations are based on the discovery that when each of two resins with a good curl-holding ability but each having a feel on the hair, are each combined with a modifying resin to make the feel acceptable, the quality of the curl-holding abilities of the resulting mixture of resins is, surprisingly, essentially equival-ent to the curl-holding ability of the component having a good curl-holding ability in itself.  This is so even if the modifying resin in itself has inferior curl-holding characteristics.  The stiff holding resin is either an octylacrylamidelacrylic acid/ methylmethacrylate copolymer (sold by The National Starch Co. under the trade designation Resin 28-4961, and is referred to hereinafter as &#34;Resin 28-4961&#34;) and/ or an octylacrylamide/acrylates/butyaminoethyl methacrylate copolymer wherein the acrylates include to or more monomers consisting of acryl-ic acid, methacrylic acid or any of their simple esters, such as methyl methacrylate and hydroxypropyl methacrylate (sold by The National Starch Co.), having the CTFA name Amphomer in combination with a mod-ifying resin.  The latter is an acrylate/acrylamide copolymer (sold by Ciba-Geigy Corporation under the trade name Ultrahold-8) having the CTFA name Acrylate/acrylalllide copolymer.  A combination of at least one of the aforementioned stiff-holding resins with the Acrylate/ acrylamide copolymer modifying resin is the principal ingredient of the hair spray compositions of the present invention.
PURPOSE:To provide the preventive for gingivitis, by using an organic solvent- soluble fraction of a crude drug of Zingiberaceae family. CONSTITUTION:One or more kinds of crude drugs of Zingiberaceae faimly [e.g. SHOKYO (rhizome of Zingiber officinale), KANKYO (dried rhizome of Zingiber officinale), SHUKUSHA (fruit of Amomum xanthioides), YAKUCHI (fruit of Alpinia oxyphylla), SHOUZUKU (fruit of Elettaria cardamomum), KOUZUKU (fruit of Alpinia galanga), etc.] are extracted with an organic solvent, preferably a polar solvent (e.g. ethanol, acetone, ethyl acetate, etc.). The amount of the solvent is preferably &gt;=3pts.wt. per 1pt. of the dried crude drug, and the extraction is carried out preferably at 25-45 deg.C for &gt;=1hr, especially for 12-24hr. The extraction is repeated preferably twice or thrice to obtain the Zingiber crude drug fraction soluble in an organic solvent. The objective preventive for gingivitis can be prepared by using the fraction as a component. In the case of using the agent as a composition for oral cavity application, the amount of the agent is preferably 0.001-10wt% of the whole composition in terms of the extract. It can be used in the form of tooth paste, tooth powder, mouth wash, troche, tablet for gargling, etc.
PURPOSE:To obtain an antilipemic agent, containing a specific benzoxazole derivative or salt thereof as an active ingredient, capable of raising high-density lipoprotein(HDL)-cholesterol value while reducing blood serum cholesterol value and useful for preventing and treating hyperlipemia and arteriosclerosis. CONSTITUTION:An antilipemic agent containing a compound expressed by formula I (R is phenyl, naphthyl, cycloalkyl or heterocyclic group optionally having a substitutent group; Alk is single direct bond, lower alkenylene, lower alkynylene or lower alkylene optionally having a substitutent group; the dotted line indicates that the bond may be double bond), e.g. 5-[(2,4-dioxothiazolidin-5-yl) methyl]-2-[4-(dimethylamino)benzyl]benzoxazole, as an active ingredient. The dose of the above-mentioned compound is 5-200mg/kg, preferably 10-20mg/kg a day. The compound expressed by formula I is novel and obtained by condensing a compound expressed by formula II (R&lt;1&gt; is OH, alkoxy, etc.; Y is O or NH) with a compound expressed by formula III.
Composite materials that can be used to block ultraviolet radiation of a selected wavelength range are disclosed. The materials include dispersions of particles that exhibit optical resonance behavior, resulting in absorption cross-sections that substantially exceed the particles&#39; geometric cross-sections. The particles are preferably manufactured as uniform nanosize encapsulated spheres, and dispersed evenly within a carrier material. Either the inner core or the outer shell of the particles comprises a conducting material exhibiting plasmon (Froehlich) resonance in a desired spectral band.  The large absorption cross-sections ensure that a relatively small volume of particles will render the composite material fully opaque (or nearly so) to incident radiation of the resonance wavelength, blocking harmful radiation.  The materials of the present invention can be used in manufacturing sunscreens, UV filters and blockers, ink, paints, lotions, gels, films, textiles, wound dressing and other solids having desired ultraviolet radiationabsorbing properties. The materials of the present invention can be used in systems consisting of reflecting substances such as paper or transparent support such as plastic or glass films. The particles can be further embedded in transparent plastic or glass beads to ensure a minimal distance between the particles.
PROBLEM TO BE SOLVED: To obtain the subject composition which decomposes plaque efficiently and gives excellent dental caries preventive effect on malocclusion having a high dental caries risk and on children by formulating fine particles of calcium carbonate with dextranase. SOLUTION: The composition for oral cavity is obtained by mixing (A) preferably 0.1-7 wt.% of fine particles of calcium carbonate, which possesses BET specific surface area of 10-50 cm&lt;2&gt; /g and average grain size of 1 μm or less in the primary grain, based on the whole weight of the composition, (B) 1.5-200 units of dextranase and preferably (C) 0.01-0.5 wt.% of an alkyloyl sarcosinate (e.g. lauroyl sarcosinate and the like). This composition can be prepared as toothpastes, liquid dentifrices, mouth washes and troches. It the case of, for example, dentifrices, the composition can be formulated with abrasives (e.g. silica gel, precipitated silica, etc.), viscosity-increasing agents (e.g. glycerol, sorbitol, etc.), surfactants, sweetening agents, antiseptics, pigments and perfumes.
&lt;P&gt;PROBLEM TO BE SOLVED: To solve conventional problems of falling of a disk-shaped portion and inconvenience when peeling.  &lt;P&gt;SOLUTION: This mount 1 for fixing patch sheets has a peel-off layer to which an adhesive face of the patch sheet 2 is peelably stuck, on its one surface, and is formed into a long rectangular shape so that a plurality of patch sheets 2 are alignedly stuck to the peel-off layer. A patch area S of each patch sheet 2 is formed with cuts 3a and 3b traversing each patch area S and reaching the edge. Each of the cuts 3a and 3b includes a linear portion 30 and an arcuate portion 31 extending half around the center C of the patch area S of the patch sheet 2. The arcuate portion 31 is adapted to be cut open and raised when being folded along the linear portion 30.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PURPOSE:To obtain a 3-exo-methylenecepham deriv. of high purity by electrolyzing a 3-halomethylcephem compound having a specified structure in an org. compound contg. water. CONSTITUTION:A 3-halomethylcephem compound represented by formula II(where R&lt;1&gt; is arylacetylamino or the like, R&lt;2&gt; is a group protecting the carboxyl group, and X is halogen) is used as a starting material. A mixture consisting of ethers such as dioxane and water in 100:1-1:100 ratio is used as an org. solvent. The org. solvent contg. water is used by amount (weight) 0.3-1,000 times the amount of the 3-halomethylcephem compound. A supporting electrolyte such as an alkali metallic salt of perchloric acid is added to the solvent by 0.1-10% of the amount of the solvent, and the 3-halomethylcephem compound is electrolyzed. After the electrolysis, concn. and extraction are carried out. A desired 3-exo- methylenecepham deriv. of high purity represented by formula I can be obtd. without causing the problem of handling or disposal.
PURPOSE:To obtain the titled compound useful as pharmaceuticals such as analgesic, etc., in high purity, by recrystallizing 2-(10,11-dihydro-10-oxobenzo[b, f]thiepin-2-yl)propionic acid with acetone-water. CONSTITUTION:1pt.wt. of 2-(10,11-dihydro-10-oxobenzo[b,f]thiepin-2-yl)propionic acid of formula is mixed with 3-10pts. (W/V), preferably 4-8pts. of acetone and 50-60% water based on the acetone. Preferably after seeding nuclei of the compound of formula, the mixture is vigorously agitated and added dropwise with water of an amount of 1.4-2.0 times the volume of the acetone. The water is preferably dripped little by little at the initial stage. After the completion of dripping, the agitation of the mixture is continued and the precipitated crystal is separated by filtration, washed with acetone-water mixture and dried at &lt;=60 deg.C to obtain the objective compound.
A high-intensity pulsed-electrical-field (HIPEF) apparatus chemically induces lysis of ocular tissue within a localized portion of an eye. Instead of broadly applying a lysis affecting solution (e.g., plasmin) to the eye, the apparatus delivers solution to only a portion of the eye. The apparatus then alters the effectiveness of the solution delivered by applying a HIPEF to that solution. In some embodiments, the apparatus delivers a solution that does not substantially affect lysis of ocular tissue and then enhances the solution&#39;s effectiveness by applying a HIPEF. As the apparatus applies the HIPEF with high precision, the HIPEF only enhances the effectiveness of the solution within select and localized portions of the eye. The apparatus is especially advantageous for vitreoretinal surgery, whereby the apparatus may selectively induce lysis of vitreous within a localized portion of the vitreous cavity, without significantly affecting adjacent retinal tissue.
The invention discloses an enzyme mask, and belongs to the technical field of traditional Chinese medicine cosmetic mask production. The mask is composed of a zeolite soft peel-off enzyme mask, a pallas pit viper&#39;s gall and spirulina powder enzyme mask, a big bryozoatum paste enzyme mask, a snake oil formed enzyme mask, a medical stone and pottery clay enzyme mask, and vegetable and fruit extract and enzyme nano powder. Mask is a multi-functional cosmetic having integrated functions of cleaning, skin caring, nourishing, beautifying, wrinkle preventing, and aging resisting. The mask is painted on the facial skin, then a membrane is formed on the skin after the mask is dried for a while, and finally the mask is removed or washed away. Through the steps mentioned above, the mask can achieve the functions of nourishing the facial skin, promoting the skin metabolism, nourishing the facial skin cell, and enhancing the cell activity. Moreover, the mask also has the functions of dispelling and removing toxin, removing scurf and dirt, softening the epidermal layer, moistening and softening the skin, preventing skin wrinkles, resisting aging, beautifying, and maintaining young and beautiful.
Nanostructures, compositions and methods for treating cancers and other conditions are provided. In some cases, the nanostructures and/or compositions may be used to treat cancers or other diseases or conditions at least in part by controlling cholesterol metabolism in cells. The nanostructures and compositions may be used, for example, to control cholesterol influx and/or efflux in cells. In some cases, the nanostructures or compositions may be used to kill the cells. Examples of cancer cells that may be affected by the nanostructures and compositions described herein include those having scavenger receptor type B-I (SR-B1), B-cell lymphoma cells, non-Hodgkin&#39;s lymphoma cells, melanoma cells and/or others. In some embodiments, the nanostructures may be mimics of natural high-density lipoprotein (HDL).
PROBLEM TO BE SOLVED: To obtain a therapeutic drug for damaged spinal code of high safety which contains a specific compound as an active ingredient, has treating and improving effects on the damage to spinal code, preventing the shift from the imperfect damage to the perfect damage and minimizes the troubles caused by the damage to spinal code such as acroparalysis. SOLUTION: This therapeutic agent contains (±)-N,N&#39;-propylene-di(nicotinamide) (generic name: nicaraven) or its salt as an active ingredient. The agent is preferably given intravenously or intraperitoneally in the form of a solution or suspension. The dose of the nicaraven or its salt is preferably an amount that its concentration becomes 10&lt;-5&gt; -10-&lt;3&gt; mol/ml in blood or spinal fluid. It is used together with a steroid preparation such as methylprednisolone and other drugs for treatment of neurological disorder, or they may be mixed or given at a time difference mode. In addition, it can be combined with a low spinal code warm therapy.
FIELD: medicine. SUBSTANCE: method involves administration of medicinal herb infusion at therapeutic doses taken at equal ratios by mass for 0.5-2 months in combination with enterosorbent. Herbal species has common immortelle flowers, marjoram herb, Jerusalem-sage herb, nettle herb, pot-marigold flowers, tormentil roots, peppermint leaves, wild carrot seeds, colt&#39;s foot herb, common wormwood herb, matricary flowers, milfoil herb, dill seeds, hop cones, sage leaves, trefoil leaves, erva woolly herb, rose fruits and coriander seeds. Method can involves additional bile duct clearing with the use of vegetable oil. Before oil administration patient takes enterosorbent and spasmolytic and after vegetable oil taking heat is applied on reflexogenic zones (start point of liver and gall bladder meridians, first and ring finger of foot). Maize oil is taken as vegetable oil. Method ensures to soft, grind and dissolve gallstones partially and remove their from organism being without surgery operation. EFFECT: enhanced effectiveness of method. 3 cl, 1 tbl
This invention relates to stents coated with hydrophilic polymers containing S-nitrosothiols, which are able to provide local delivery of both nitric oxide and S-nitrosothiols by diffusion. This device is intended for coronary angioplasty applications with the purpose of inhibiting acute and chronic restenosis and refers to processes of stent coating with hydrophilic polymers containing incorporated S-nitrosothiols. This invention refers to an intracoronary implant device used in medical procedures, and introduces new S nitrosothiol-eluting stents coated with hydrophilic polymer multilayers. The hydrophilic polymers used for coating are polyvinyl alcohol, polyvinylpirrolidone and polyvinyl alcohol/polyvinylpirrolidone, polyvinyl alcohol/polyethylene glycol, polyvinylpirrolidone/polyethylene glycol and polyvinyl alcohol/polyvinylpirrolidone/polyethylene glycol blends. The S-nitrosothiols incorporated to the polymer coatings are mainly primary S-nitrosothiols, characterized by the fact of the nitric oxide (NO) molecule being covalently bound to a sulfur (S) atom which, in turn, is linked to a primary carbon in the molecule&#39;s structure, thus constituting the S—NO chemical group. The coating processes include immersion of the stents in polymer solutions containing S-nitrosothiols and nebulization processes of the polymer solutions containing S-nitrosothiols onto the stent surface.
FIELD: medicine. SUBSTANCE: proposed method is based upon use of disposable bandages coated with thin layer of finely dispersed herb tea comprising lin seeds, sweet clover seeds, ginger and kurkuma plant. Said herbs are taken in weight ratio that cannot vary. Phytobandages are applied onto biologically active areas of patient&#39;s forearm and crus. Following areas are biologically active in influenza cases and in acute respiratory diseases: - on feet - one third of crus (shin) starting from malleolus, i.e. third of crus; - on arms - one half of forearm starting from wrist, i.e. distal half of forearm. Bandages thus-applied must be worn for two days, followed by six-hour break. Next fresh bandages coated with same herb tea composition are applied. Recovery is observed at second-sixth day. EFFECT: effective and mild method of treatment.
PURPOSE:To obtain a new phenanthrene derivative and a salt thereof having inhibitory activity against interleukin-1 and useful as an adjuvant arthritis depressor. CONSTITUTION:A compound shown by formula I [group A-B is group shown by formula II (R&#39; is H or lower alkyl) or formula III (R&lt;2&gt; is H or lower alkanoyl), etc.], such as 3,4,4a,5,8,9,10,10a-octahydro-1,4a-dimethyl-7-(1- methylethyl)-5,8-dioxo-2phenanthrenecarboxylic acid. The compound is obtained by extracting and isolating from Tripterygium wilfordii Hookfil var. regelii Makino or reacting a corresponding compound wherein R&lt;1&gt; is H with an alcohol in a proper inert solvent (e.g. diethyl ether) in the presence of acid catalyst (e.g. aluminum chloride) at room temperature to reflux temperature for 1-72 hours.
PURPOSE:To obtain a skin-protecting agent having excellent water-resistance and liquid chemicals resistance and capable of protecting the skin from water or liquid chemicals over a long period. CONSTITUTION:This skin-protecting agent is produced by compounding (A) a skin agent, preferably a high-polymer having a molecular weight of 2,000-300,000, e.g. a polydimethylsiloxane polymer or polyvlnyl pyrrolidone polymer with (B) a hydrophobic powder having a contact angle of preferably 90-180 deg. to water and (C) a volatile oil component, e.g. a volatile cyclic silicone solution or a light hydrocarbon oil. The compounding amounts of the components are 1-20wt.%, preferably 5-15wt.% for the component A, 1-10wt.%, preferably 2-5wt.% for the component B and &gt;=30wt.% based on the total compounding oil components and 5-30wt.%, preferably 10-25wt.% based on the total protecting agent for the component C. The film-forming property and the water-repellency of the protecting agent can be improved by decreasing the content of the humectant to &lt;=5wt.%.
PURPOSE:The titled enhancer containing XVAU or its ester or salt as an active ingredient. CONSTITUTION:An enhancer for antitumor effect, containing a compound (XVAU) shown by the formula (R is OH, or phosphoric acid residue; X is halo gen, such as Br, Cl, I, etc.) or its 5&#39;=monophosphoric ester or its salt (XVAUP) as an active ingredient. In a field of remedying malignant antitumors, a target to be applied by actiontherapeutics or by therapy of antitumor agent, the enhancer is used with the remedy treatment, to raise antitumor effect. When it is used as a radiation sensitizer, it is administered before or after irradiation. Action-therapeutics with a lower dose range 4than a conventional one by the use of the enhancer in the therapy. Also in chemotherapy, the enhancer as an enhancer for increasing antitumor effect is administered simultaneously with an antitumor agent or before or after administration of the antitumor agent. A dose is 0.5-50mg/kg/day.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers.  &lt;P&gt;SOLUTION: The diagnostic, prognostic, and therapeutic uses for detecting COP1 overexpression in a variety of cancers are provided. The methods and uses can further include detecting p53 expression. Also, reagents and kits for use in screening for test compounds that interfere with COP1 and p53 binding are provided. A method is for diagnosing a cancer in a subject. The method includes detecting COP1 levels or COP1 activity in the cancer in the subject.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT