anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
The invention discloses an application of a Chinese patent drug to preparation of a medicament for restraining BGC-823 cell proliferation. The Chinese patent drug refers to Shuanghu liver clearing particles, which comprise Wuling bacterium powder serving as a major component, contain 19 kinds of amino acids such as adenosine, polysaccharides, sterol and glutamic acid, Y-aminobutyric acid, lysine and the like, further contain a plurality of components such as vitamins (VitE, B1, B6, K1 and the like), trace elements (Zn, Fe, Ca and the like) and the like. The Chinese patent drug has the effects of reinforcing the kidney and brain and nourishing the heart to calm the mind, and is suitable for heart-kidney imbalance of neurasthenia with manifestations of insomnia, amnesia, general lassitude, soreness and weakness of waist and knees, soft pulse or myasthenia gravis and the like. The Chinese patent drug is suggested to be taken orally three times every day, by three particles at one time, or is taken by following the doctor&#39;s advice. Every particle is o.33g by weight. According to tests, the Chinese patent drug can be used for restraining BGC-823 cell proliferation.
&lt;P&gt;PROBLEM TO BE SOLVED: To find out a gene encoding a protein having the possibility of participating in development and aggravation of tumor diseases and to provide a means for regulating actions of the protein and a means useful for preventing and treating diseases caused by an abnormality of the protein.  &lt;P&gt;SOLUTION: A DNA in which the expression is accelerated in a tumor tissue is found out and the protein encoded with the DNA is found to exhibit the dephosphorylating activity, bind to CSE1L (chromosome segregation gene 1-like) and dephosphorylate the CSE1L and participate in the cell proliferation. On the basis thereof, a method for inhibiting cell proliferation and an inhibitor characterized as inhibiting the expression and/or function of the protein are provided. A method for inhibiting dephosphorylation of the CSE1L and a dephosphorylation inhibitor thereof, a method for preventing and treating the tumor diseases and a preventing and treating agents are provided. A method for identifying a compound inhibiting the cell proliferation, a compound inhibiting the binding of the protein to the CSE1L and a compound inhibiting the dephosphorylation of the CSE1L with the protein, a method for judging the tumor tissue by measuring the expression level of the DNA in the tissue and a reagent kit are provided.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
The invention provides a pharmaceutical composition for treating a Heyi sexual disease, a nerve-soothing pillow and a preparation method thereof, and belongs to the technical field of Chinese (Mongolia) medicaments. The pharmaceutical composition comprises the following components in parts by weight: 400-600 parts of aquilaria sinensis, 90-120 parts of juniper and 4-6 parts of white sandalwood. The invention also provides a pillow with functions of calming nerves and helping sleep, which comprises a pillowcase, a pillow core and pillow core fillers, wherein the pillow core fillers comprise the pharmaceutical composition. The invention takes the aquilaria sinensis as a monarch drug, has cool nature, and has the efficacies of relieving &#39;heyi&#39;, clearing heat, relieving pain and relieving asthma; the juniper is taken as a ministerial drug, has cool property and has the effect of clearing heat; sandalwood is used as a guiding drug and has the effect of clearing heat due to cold nature. The invention has the functions of clearing heat, soothing the nerves and hypnotizing after the compatibility of the medicines. The medicine composition or the pillow has obvious curative effect on patients with the Heyi disease who have symptoms of dizziness, headache, palpitation, asthma, insomnia and the like.
Disclosed herein are compositions for use as a sunscreen or sunblock which, in some embodiments, may provide long-acting, waterproof or water-resistant, broad spectrum topical sun protection with activity up to weeks without reapplication. In some embodiments, the compositions may include a base and one or more active ingredients. In some embodiments, the base may include an adhesive component, which upon application to a user&#39;s skin, adheres the base to the user&#39;s skin. In some embodiments, the adhesive component is adapted to hold the active ingredients on the user&#39;s skin for at least about 8 hours, such as at least about 24 hours, such as at least about 3 days, or even at least about 2 weeks. Furthermore, in some embodiments, the composition may be waterproof or water-resistant. In some embodiments, the one or more active ingredients may include a photodamage protective ingredient, and/or a photodamage reparative ingredient.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a Chinese herbal composition for improving blood circulation, capable of preventing diseases which involves cardiovascular and cerebroavscular diseases or retarding aging by activating the blood from a congestive state and improving the cardiovascular and the cerebrovascular functions and to provide a method for producing the composition.  &lt;P&gt;SOLUTION: This herbal composition is obtained by extracting active ingredients of Radix Angelicae sinensis, Radix Ligustici Chuanxiong and Radix Ginseng with an extracting agent. The herbal composition comprises 30-50 wt.% of Dang Gui root (Radix Angelicae sinensis), 35-65 wt.% of Chuan Xiong root (Radix Ligustici Chuanxiong), and 7-13 wt.% of Ginseng root (Radix Ginseng). FIG. 1 shows the chronic toxicity test of the herbal composition obtained when the composition is administered into Wistar rats.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
The present invention provides a new method for synthesizing compounds 1 and 2 with wide spectrum antiviral activity and analogues thereof. A compound 3 is dissolved in pyridinium and reacts with 4, 4&#39;dimethoxy trityl chloride for obtaining a compound 9 with a high yield. The hydrogen chloride is removed from the compound 9 by butanol potassium, and a compound 10 with a high yield can be obtained. The compound 10 is oxidized by m-chloroperoxybenzoic acid, and a compound 11 with high selectivity can be obtained. Rf values of the compound 11 and a compound 12 are obviously different, so the compound 11 can be separated from the compound 12 by a common silica gel column. The compound 11 and the compound 12 respectively react with basic groups so as to obtain a compound 13 and a compound 15 with a moderate yield. 4, 4-dimethoxy triphenmethyl of the compound 13 or the compound 15 is removed by acetic acid, and the compound 1 or the compound 2 or a compound 14 or a compound 16 with a high yield can be obtained. The compound 1, the compound 2 and analogues thereof with higher yields can be obtained by the same raw materials by the present invention. The operation of the present invention is simple and feasible.
PROBLEM TO BE SOLVED: To obtain a 1α,25-dihydroxycholecalciferol metabolism-improving agent containing activated carbon as an active ingredient and capable of effectively treating renal osteodystrophia and vitamin D3 activation failure. SOLUTION: This 1α,25-dihydroxycholecalciferol metabolism-improving agent contains activated carbon, preferably spherical activated carbon, as an active ingredient. The spherical activated carbon preferably has a diameter of 0.1-1 mm, a specific surface area of 700-1,500 m&lt;2&gt; /g, a fine pore radius of 100-75,000 Åand a porosity of 0. 05-0. 8 ml/g. The spherical activated carbon includes granulated spherical activated carbon obtained from carbonaceous powder, spherical activated carbon obtained by calcining an organic polymer and spherical activated carbon originating from a petroleum-based hydrocarbon (petroleum- based pitch). The inhibitor is preferably orally administered. The improving agent is administered at a daily dose of 0.2-20 g (as the amount of the spherical activated carbon) with one or several portions for a human adult.  The preparation of the activated carbon is preferably capsules, sticks or divided packages.
PURPOSE:To obtain an anticarious substance, consisting of purified gymnemic acid prepared from Gymnema sylvestre, having high inhibitory effects on formation of bacterial plaques and capable of remarkably suppressing growth of cariogenic bacteria. CONSTITUTION:Dried leaves of Gymnema sylvestre are extracted with hot water and the resultant extract solution is adjusted to pH3 with 2N sulfuric acid to provide precipitates containing crude gymnemic acid. The precipitates are collected by centrifugal settling and the aggregates are washed with water and extracted with ethanol. The extract is then concentrated under reduced pressure and acetone in a volume of 2 times is added to the concentrate to carry out centrifugal settling. The supernatant liquid is subsequently concentrated to dryness under reduced pressure and extracted with diethyl carbonate as a solvent as the boiling point. Substances deposited from the above-mentioned solvent are collected and evaporated to dryness, subjected to high-speed liquid chromatography to afford the aimed purified gymnemic acid. The resultant purified gymnemic acid has action of inhibiting formation of glucan by cariogenic bacteria as well as surely preventing formation of bacterial plaques and is preferably used by containing in an amount of &gt;=10mM.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain an ameliorant for sleep disturbance, which has excellent effect on symptoms such as sleep disorder or sleep induction disturbance, sleep regulation action (regulation of period of REM sleep and non-REM sleep and amelioration of arousal dysfunction) on promotion of natural sleep and security of deep sleep and no adverse effect.  &lt;P&gt;SOLUTION: The ameliorant for sleep disorder having action on sleep promotion/sleep regulation comprises an extract of a plant of the genus Lepidium of the family Cruciferas. Concretely, the plant of the genus Lepidium of the family Cruciferas is Lepidium meyenii Walp. The ameliorant for sleep disorder comprises an extract of Lepidium meyenii Walp as an active ingredient. The liquors or the food or beverage having action on sleep promotion/sleep regulation comprises any of the ameliorants for sleep disorder.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
PURPOSE:To provide a glass in which radioelement ions are stably implanted by distributing element ions which can radiate beta ray by radiation of neutron near the surface of the glass body, by forming a membrane of oxide series glass around this ions, and by making on oxide nitride exist in the neighbourhood of the ions. CONSTITUTION:Charged P&lt;+&gt; ion particles are implanted into a silica glass on a specified condition, N&lt;+&gt; ions are also implanted. At this step, the ions are colloidal and a crack is created in the silica glass accompanied by the ion passing. In succession, when the silica glass is primary-heated for example at 400 deg.C in hydrogen gas, P colloid grows big in the silica glass without sublimation. Thereafter, when the silica glass is secondary-heated for example at 900 deg.C in oxigen gas, an SiO2-P2O5 series glass membrane is formed surrounding the P colloid, and as a result, the crack of the silica glass is closed. Therefore, the presence of this membrane makes P hard to elute into liquid as well as hard to sublimate.
&lt;P&gt;PROBLEM TO BE SOLVED: To fundamentally inhibit mechanism of unwanted hair growth (i.e. unwanted hair) on human body, to realize safe epilation using a major naturally occurring substance, and to enable simultaneous achievement of skin beautification and weight reduction effects.  &lt;P&gt;SOLUTION: A hair growth inhibitor is composed of a pineapple-derived enzyme, i.e. bromelain, derived from a natural fruit which is hardly harmful to human body, actinidin enzyme, i.e. kiwi fruit extract, a fermented solution of soymilk and bittern. Further addition of aloe extract, kudzu root extract, chlorella extract water-soluble collagen, royal jelly extract, propolis extract, etc., which are compatible with the above-mentioned components, as skin beautification components enables simultaneous achievement of epilation and skin beautification. Further addition of noni extract, guarana extract, perilla oil, Coleus Forskohlii etc., which are safe, highly effective and compatible with the above-mentioned components, realizes weight reduction. Through this invention, hair growth inhibition, skin beautification and weight reduction, which are the three major beauty elements especially for women, can be extremely easily and effectively achieved.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
1339256 Bleaching oils and fats HENKEL &amp; CIE GmbH 30 July 1971 [31 July 1970] 35853/71 Heading C5C [Also in Divisions A5-A6 D1-D2 and C6-C7] Oils, fats and waxes are bleached using a peroxy-compound activated by the addition of a 1,4-diacylated 2,5-diketopiperazine activator having the Formula I in which R 1  and R 2  are preferably the same and each represent a hydrocarbon group having 1 to 8 carbons which may be substituted and  R 3  and R 4  are preferably the same and each represent a hydrocarbon group having 1 to 3 carbons which may be substituted. Preferred groups R 1 , R 2  are methyl ethyl, n- or isopropyl, phenyl, tolyl or xylyl residues, optionally substituted by C 1-3  alkoxy, halogen, nitro, or cyano groups. Preferred groups R 3 , R 4  are methyl or ethyl residues, optionally substituted by hydroxyl, halogen, nitro, cyano, methoxy or ethoxy groups. Specified peroxy-compounds include hydrogen peroxide, addition products of hydrogen peroxide and urea or melamine, peroxyhydrates such as perborates, percarbonates, persilicates and perortho-, perpyro- and perpoly-phosphates, and salts of peroxymono- or peroxydisulphuric acid. The activator and peroxy compound may be formulated as a bleaching and/or oxidizing liquid, which may also contain anionic, cationic, non- ionic or amphoteric detergents, alkaline substances and complex forming substances for binding water hardening substances and heavy metal ions. The liquid preferably has a ratio of 0À5-6 acyl residues per active oxygen atom, and may be used at a pH from 7-13. Bleaching may be effected at ambient or elevated temperatures, or in two stages at different temperatures. Examples describe the activation of perborate in the presence of sodium pyrophosphate with 1,4-diacetyl-2,5-diketo piperazine, 1,4-dipropionyl-2,5-diketo piperazine or 3,6-dimethyl-1,4-diacetyl-2,5-diketo piperazine, and the activation of hydrogen peroxide with the first two activators.
This Washable Scrub Cream Polish Remover uses O/W surfactants combined with fine particles and solvent&#39;s acrylates thickener. This mainly uses the solvent that has the characteristics of high boiling point, low volatility, hydrophilic, odorless and which can effectively dissolve the nitrocellulose resin in the nail lacquer. In the ingredient, there are O/W surfactants and fine particles to more effectively remove nail lacquer and easier to wash off with water. Acrylates thickener are used to achieve the cream shape. This product is different to regular lacquer remover which has high volatility, very dehydration, and dryness characteristics. Instead, this washable scrub cream polish remover replenishes the nails and cuticles.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a solid composition applicable to a human skin and gellable on contact with water.  &lt;P&gt;SOLUTION: The composition contains hyaluronic acid, very fine inert powder and a small amount of water as essential components. The inert powder is selected from a group consisting of mica, talc, silica, polymethylmethacrylate, lauroyl lysine and corn starch. At least one further component selected from a group consisting of emulsified materials, moistened materials and pharmaceutical materials may be contained. The composition is prepared as a solid flexible thin film and is usable as cosmetics and/or therapeutic purposes.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
PURPOSE:To provide the remedy for rheumatoid arthritis exhibiting significant suppressing effect to the collagen arthritis and adjuvant arthritis in animal experiment, by using an IRA fraction as an active immuno-suppressing component. CONSTITUTION:The objective remedy for rheumatoid arthritis can be produced by using an IRA fraction obtained e.g. from the blood and placenta blood of man and mammals, Cohn&#39;s fraction IV, etc., as an active component. The IRA fraction has significant suppressing effect to the collagen arthritis and adjuvant arthritis which are animal experiment models of human rheumatoid arthritis. Especially, an IRA fraction having a molecular weight of &lt;=50,000 is preferable as a remedy for rheumatoid arthritis. It is administered especially preferably by intravenous injection in a dose of 0.1-20mg/kg daily.
The invention belongs to the field of biomedical materials. In particular to a naringin cleaning reagent for titanium surface bacterial biofilms and a preparation method and application thereof. The invention provides application of naringin in removing bacterial biofilms on the surfaces of oral implants, and provides a bacterial biofilm cleaning agent and a preparation method thereof. The bacterial biofilm cleaning reagent disclosed by the invention is simple in preparation process, easy to process and low in cost. Has the characteristics of restoring the surface characteristics of the oral implant, high cleaning efficiency and good biocompatibility. Compared with the chemical flushing agent hydrogen peroxide and the &#39;gold standard&#39; chlorhexidine which are commonly used for oral diseases, the naringin and the bacterial biofilm cleaning agent can effectively remove the biofilm of staphylococcus aureus which is formed on the surface materials of oral implants such as rough titanium and the like, recover the microcosmic characteristics of the surface, have lower cytotoxicity, can promote the adhesion and proliferation of osteoblasts, are beneficial to osseointegration again, and prevent and treat peri-implantitis.
Biologically active fission products of the adrenocorticotropic hormone are obtained by hydrolysing the hormone and simultaneously dialysing the reaction solution, the fission products being isolated from the dialysate.  The hydrolysis vessel is preferably a tube of flexible semipermeable material e.g. &#34;Cellophane&#34; (Registered Trade Mark) closed at one end, capable of being rotated, and arranged within a somewhat larger glass tube which is immersed in a water bath at a predetermined temperature.  The external liquid used for dialysis has approximately the same pH as the internal liquid, and the external liquid is continuously renewed.  Preferred hydrolytic agents are proteolytic agents such as pepsin or trypsin, but other agents such as dilute hydrochloric acid may be used.  In examples (a) the adrenocorticotropic hormone from pig pituitaries is hydrolysed with 0.05 N hydrochloric acid containing pepsin at 37 DEG  C. and the external liquid is 0.05 N hydrochloric acid continuously stirred. Every 30 minutes the external liquid is replaced by fresh liquid previously heated to 37 DEG  C.  The active material is obtained by freeze drying the dialysate; (b) Crude extract from whale pituitaries is hydrolised in 0.05 N hydrochloric acid containing pepsin and saturated with toluene.  The external liquid 0.05 N hydrochloric acid is continuously renewed.  The process is interrupted after three hours for a further addition of pepsin; (c) a crude extract from sheep pituitaries is treated as in (b).
PROBLEM TO BE SOLVED: To obtain an ultraviolet light screening cosmetic capable of producing ultraviolet light screening effects in spite of a transparent feeling possessed thereby without using a fine particle ingredient by using at least one of pigments having the surface coated with a specified polymer. SOLUTION: This ultraviolet light screening cosmetic is obtained by using at least one of pigments having the surface coated with at least one of polyarylate compounds of the formula [R&lt;1&gt; and R&lt;2&gt; are each an alkyl, an allyl or an aryl; (n) is a number of &gt;=5 expressed in terms of number-average molecular weight]. The compound of the formula is an ester condensation polymer compound of bisphenols with terephthalic acid and isophthalic acid. The composition of the terephthalic and isophthalic acid residues in the compound is preferably (80:20)-(20:80), especially preferably (60:40)-(40:60) expressed in terms of molar ratio. The powder of the polyarylate compound is preferably blended in an amount of 10-20wt.%. The powder size of the polyarylate compound is preferably &lt;=50μm, especially preferably 1-20μm expressed in terms of median diameter.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a new and safe elastase activity inhibitor and cosmetic composition.  &lt;P&gt;SOLUTION: The elastase activity inhibitor and the cosmetic composition contain an extracted or pressed material of at least one kind of a plant of the family Orchidaceae selected from varieties of Epipactis papillosa Franch et Savat., Neottia nidus-avis (L.)L.C. Rich. var. manshurica Komar, Cephalanthera longibracteata Blume and Dacrylorhiza incarnata (L.) Soo. These components have excellent elastase activity inhibiting action and high safety and are usable as an elastase activity inhibitor and a cosmetic composition imparting the skin with luster and springiness and preventing the aging of the skin.  &lt;P&gt;COPYRIGHT: (C)2004,JPO