anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PURPOSE:To obtain the subject cosmetic useful for treatment after shampooing by blending an amphoteric surfactant having high safety with a cationic polymer, adding an oil agent and an organic acid or an inorganic acid and controlling pH to &lt;=5. CONSTITUTION:An amphoteric surfactant (especially preferably amidoamino acid type amphoteric surfactant or imidazoline type amphoteric surfactant) is combined with a cationic polymer (e.g. cationic cellulose derivative or quaternized polyvinyl pyrrolidone derivative), an oil agent (e.g. dimethylpolysiloxane or dimethylcyclopolysiloxane), a germicide (e.g. piclotolamin or triclosan) and an organic acid or an inorganic acid and the whole composition is adjusted to pH &lt;=5 to give an emulsion cosmetic for scalp and hair. This cosmetic provides hair with excellent smoothness and flexibility, splendidly keeps scalp healthy, has low irritation and good emulsion stability.
The invention relates to a novel influenza virus strain and to the influenza virus vaccine containing said strain. The new strain, which is the DNCM No. I-099 strain, is prepared by recombination of the influenza A/PR/8/34 virus strain with the influenza A/California/10/78 (CNCM No. I-098) virus strain. The vaccine is prepared by allowing the CNCM No. I-099 strain to grow in the allantoic cavity of fertile hen&#39;s eggs, harvesting and freeze-drying the yielded virus material. The strain and the vaccine deriving therefrom are valuable for the immunization against influenza caused by influenza type A (H1N1) virus strains.
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, namely to children&#39;s anesthesiology and resuscitation science, and can be used as prevention of bronchopulmonary dysplasia in newborn babies with very low and extremely low body weight. For this purpose, to newborn babies, who have been for not less than 7 days of life on non-invasive ALV in mode Biphasic/DuoPAP through nasal cannulas or in mode CPAP through nasal cannulas and on invasive ALV, introduced is &#34;Surfactant BL&#34; in single dose 53-75 mg/kg. Introduction is performed from 8 to 27 days of life inclusive, in sessions 10-15 minutes long depending on volume of Surfactant BL suspension by nebuliser with aerosol generator OnQ Aeroneb« Pro. At most 5 sessions are carried out. ^ EFFECT: method makes it possible to prevent development of bronchopulmonary dysplasia in said category of patients due to introduction of surfactant BL, which contains surfactant-associated proteins by means of nebuliser, making it possible to introduce medication at rate, optimal for alveolar deposition, preserving its molecular integrity. ^ 4 tbl, 4 ex
&lt;P&gt;PROBLEM TO BE SOLVED: To produce a conventionally unknown heterooligosaccharide by utilizing a sugar-transfer reaction of an α-amylase (EC 3,2,1,1) which is a hydrolytic enzyme.  &lt;P&gt;SOLUTION: The method for producing an oligosaccharide composition comprises reacting the α-amylase with a mixed sugar liquid containing a starch and/or a hydrolyzed product of the starch, and oligosaccharides which are an enzymically hydrolyzed product of a sugar alcohol, a monosaccharide except glucose, or the starch, and which contain the oligosaccharides except the oligosaccharides having the glucose bonded thereto by α-1,4 bond and/or α-1,6 bond. The method for producing an oligosaccharide composition involves reacting a β-amylase or a glucoamylase with the oligosaccharide composition produced by the method. The oligosaccharide compositions are produced by the methods. The heterooligosaccharide is obtained from the oligosaccharide compositions. The sugar composition contains the oligosaccharide composition or the heterooligosaccharide. The food, beverage, seasoning, taste quality-improver, composition for dental health, cosmetic, fodder or composition for shampooing contains the oligosaccharide composition, the heterooligosaccharide or the sugar composition.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a therapeutic agent for dementia patients, which is effectively used in aromatherapy and suppresses delirium combined with dementia and/or BPSD (Behavioral and Psychological Symptoms Of Dementia).  &lt;P&gt;SOLUTION: The therapeutic agent for dementia patients includes an awakening essential oil such as tea tree essential oil, and is applied to dementia patients in daytime. Preferably the therapeutic agent for dementia patients is sprayed in air and introduced into the bodies of dementia patients through breathing, mucous membrane and percutaneous absorption. The therapeutic agent for dementia patients is used together with an efficacy modulator utilized at night. The therapeutic agent for dementia patients dominantly suppresses delirium and/or BPSD in a short period.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
PURPOSE:To prevent the incorrect issue of prescriptions by supplying the prescriptions to a transmission equipment through a terminal which can process the picture information and by collating the proper graphics such as a signature, etc., included in the picture information with the information on a specific person that is previously stored after recognition of the proper graphics. CONSTITUTION:A pair of facsimile terminals FAX-A and FAX-B are installed at an outpatient clinic, and the terminal FAX-A is used for transmission of prescriptions and the terminal FAX-B is used for reception of medicine coupons respectively. Meanwhile a facsimile terminal FAX-C is installed at an accounts/pharmacist&#39;s office. These three facsimile terminals are connected to an automatic prescription transmission equipment 1 containing an issuer deciding function via a circuit. A doctor transmits in facsimile the prescriptions written by himself to the equipment 1 through the terminal FAX-A. The equipment 1 combines together the information on the contents, the serial numbers and the issues (doctors) of prescriptions and transmis them to the terminal FAX-C as a prescription indicating form 4C. Then each doctor writes his proper signature, etc., on an input prescription form, and the picture information on these prescription forms are collated with the collating information on issuers which are previously registered in the device 1. Thus the incorrect issue of prescriptions can be prevented to the outsiders.
PURPOSE: An antipruritic composition containing quercetin and astragalin is provided to ensure suppress and relieve skin itching and to relieve atopic dermatitis. CONSTITUTION: An external use skin composition for treating atopic dermatitis contains 0.001-10 wt% of each quercetin of chemical formula 1 and astragalin of chemical formula 2. Qeurcetin is a natural compound belonging to polyphenol flavonoid of fruits, vegetables, and various plants. Astragalin is a flavonoid glycoside compound contained in plant leaves including persimmon leaves. The composition is manufactured in the form of a pharmaceutical compositon of a cream, essence, lotion, ointment, paste, liniment, external use liquid, aerosol, and plaster. [Reference numerals] (AA) Structure of 3.3&#39; .4&#39; .5.7-pentahydroxy flavone(quercetin); (BB) Structure of kampferol-3-0-glucopyranoside(astragalin)
Techniques for generating recommendations using machine learning with respect to semantic concepts defined in a knowledge graph. A hair profile is determined for a user based on inputs related to the user. Determining the hair profile includes extracting attributes of the user from the inputs using natural language processing, computer vision, or both, and identifying respective nodes for the extracted attributes in the knowledge graph. The knowledge graph is created via machine learning using population data including hair-related data in order to identify relationships between semantic concepts represented by nodes of the knowledge graph. The nodes include discrete properties such as individual hair attributes, ingredients of products, or otherwise discrete characteristics of factors that may affect a user&#39;s hair or related health conditions. A generalized recommendation is generated based on the hair profile. A personalized recommendation may be generated based on the generalized recommendation and progress logged by the user.
The invention provides a method of inducing a protective response in ceils by activating a heat shock response, via heat shock transcription factor (HSF), without stressing the ceils. The invention is based on the surprising discovery that HSF can be activated in non-stressed ceils by disrupting interaction with the repressive cognate protein, Hsc70. As described herein, non-steroida! anti-inflammatory drugs (NSAID), inciuding salicylic acid and ibuprofen, can stimuiaie HSF DNA binding, Hsp70 transcription and Hsp70 protein synthesis in non-stressed ceils. By activating HSF, the degenerative effects of certain neurodegenerative proteins such as pαiyglutamine repeat proteins (Huntington&#39;s disease) and the α-synucleiπ protein (Parkinson&#39;s disease) can be offset. The invention thus provides a method of ameliorating symptoms of neurodegenerative disease.
NEW MATERIAL:A compound of formula I (R is H, methyl; X is formula II, H3C-N; Y is formula II, formula III, or N-CH3). EXAMPLE:Tetradrine-2-N-beta-oxide. USE:Analgesic, anti-inflammatory, antiallergic or hypotensor. PREPARATION:For example, &#39;FUNBOUYI&#39; (roots of a plant in Meni spermaceae) is extracted with methanol. Then, methanol is removed from the extract to obtain the essence. The essence is dissolved in a methanol-water mixture, extracted with n-hexane to remove components soluble in lipid, then the solvent is distilled off under reduced pressure. Aqueous ammonia is added to the residue and the mixture is extracted with chloroform. The extracted essence is purified with column chromatography to give the compound of formu la I.
In previous studies, Copolymer 1 given at a dose of 20 mg daily has been shown in a controlled study to decrease the relapse rate in multiple sclerosis (MS) by about 30 % over placebo. In our clinical studies, daily subcutaneous (SC) administration has decreased the relapse rate by 73.4 % from baseline. In the present study, relapsing MS patients were treated with 20 mg Copolymer 1 on alternate days. Sixty eight patients were recruited: 51 and 40 patients completed one and two years respectively. The relapse rate during the two years of treatment decreased by 80.8 % compared to the two years prior to treatment (means 0.56±1.02 vs 2.91±1.10, respectively, P&lt;0.0001). The Expanded Disability Status Scale (EDSS) did not differ from baseline following the first year of treatment, but increased somewhat at the end of the second year (baseline=2.72±1.55, one year 2.71±1.59, two years 2.97±1.80, P&lt;0.008). The drug was very well tolerated. This study suggests that alternate day therapy has beneficial effects and is well tolerated in relapsing Multiple Sclerosis, comparing favourably with the effects of daily injections of Copolymer 1.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a new signal transduction protein participating in signal transduction of proinflammatory cytokine (interleukin-1) IL-1: a method for screening a compound inhibiting the signal transduction of IL-1 using the protein: and an IL-1 signal transduction inhibitor containing a compound separable by the screening as an active component.  &lt;P&gt;SOLUTION: There is provided a new signal transduction factor TAB2 acting as an adaptor molecule of TRAF6 and TAK1 and mediating activation of TAK1 in signal transduction of IL-1. TAB2 induces activation of NF-κB and JNK by IL-1. The signal transduction of TAB2 by IL-1 is inhibited by inhibiting the signal transduction of TAB2 by a dominant negative mutant of TAB2. There is further provided a medicine inhibiting signal transduction of TAB2 and having anti-inflammatory action.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To contrive expansion of usage of the stems and leaves of sweet potatoes and to provide a new anti-obesity agent and food, by finding a new function of the stems and leaves of sweet potatoes.  &lt;P&gt;SOLUTION: The invention provides the anti-obesity agent comprising a processed material of the stems and leaves of sweet potatoes, γ-aminobutyric acid or its derivative. The anti-obesity agent of this invention has superior fat accumulation suppressing action and exhibits anti-obesity effect. Furthermore, the invention provides the food containing this anti-obesity agent. The anti-obesity agent and the food of the invention can prevent obesity by exhibiting anti-obesity effect.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a hyaluronidase inhibitor derived from hyaluronic acid contributing to moisture retention of the skin etc., and a wrinkle formation inhibitor containing the inhibitor.  &lt;P&gt;SOLUTION: The hyaluronidase inhibitor includes a phosphorylcholine group-containing hyaluronic acid derivative. There may be a case in which the phosphorylcholine group-containing hyaluronic acid derivative is phosphorylcholinehyaluronic acid. The derivative maintains moisture retaining property being a main function of hyaluronic acid and has increased hydrophilicity and biocompatibility by introduction of phosphorylcholine group and ability of inhibiting hyaluronidase activity to decompose hyaluronic acid. The wrinkle formation inhibitor includes the hyaluronidase inhibitor.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
The present invention relates to a method of using 17alpha-dihydroequilenin and metabolic conjugates thereof to prevent and reduce atherogenesis in males and females without causing endometrial proliferation in females and without producing feminizing changes in males. 17alpha-dihydroequilenin was evaluated for its effects on plasma lipid and lipoprotein, glucose, insulin concentrations, coronary artery vasomotor function, and reproductive organ and mammary gland proliferation in atherosclerotic mammals. 17alpha-dihydroequilenin was found to prevent endothelium-dependent vasoconstriction in males (p&lt;0.05) and ovariectomized females (p&lt;0.08). 17alpha-dihydroequilenin treatment increased plasma apolipoprotein A-1 concentrations (p&lt;0.05) and lowered fasting insulin concentrations (p&lt;0.05) without changing fasting plasma glucose concentrations in males. 17alpha-dihydroequilenin had no other effects on plasma lipid and lipoprotein concentrations in either males or females. Also, 17alpha-dihydroequilenin exhibited no trophic effects on the uterus, endometrium, or breast, and no effect on either prostatic or testicular weight. Thus, 17alpha-dihydroequilenin may prevent breast and prostatic hyperplasia and neoplasia, and has no feminizing effects on the male urogenital system or mammary gland.
PURPOSE:To efficiently obtain the titled compound having inhibitory action on cell division in high yield, by extracting tissues of a leguminous plant with a specific solvent, removing the solvent fro the aqueous solution layer, adjusting the pH of the aqueous solution layer, extracting the adjusted layer with a specific solvent to separate and purify the titled compound. CONSTITUTION:Tissues of a leguminous plant, e.g. white clover (Trifolium repens L.) are extracted with an aqueous solution of a water-soluble solvent having &lt;=95 deg.C boiling point, e.g. ethanol or acetone, which is then removed from the treated solution by evaporation or distillation under ordinary pressure or reduced pressure. The resultant residual aqueous solution layer is adjusted to 6.5-8.5pH by adding sodium bicarbonate thereto and the solvent extraction is carried out by using a polar solvent slightly soluble in water, e.g. ethyl acetate or dichloromethane. The extracted solution is then subjected to gel filtration with preferably an oleophilic gel column, e.g. sephadex column LH-20, separated and purified to separate the aimed compound. EFFECT:The aimed compound can be readily separated and purified in a large amount rapidly in a short time and the method is industrially advantageous.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a stable metastin derivative having excellent bioactivity (cancer metastasis inhibiting activity, cancer growth inhibiting activity, etc.).  &lt;P&gt;SOLUTION: This metastin derivative is improved in stability in blood, etc. than natural-type metastin, and shows excellent cancer metastasis inhibiting activity and cancer growth inhibiting activity by modifying the constituting amino acid of metastin with a specific modifying group. This metastin derivative has gonadotropic hormone antisecretory activity, sex-hormone antisecretory activity, etc. which are completely different from the activities known currently.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To obtain a massage cream which can remove positive static electricity and activate the cells constituting human body and humor such as blood by using silicon oxide in the cream. SOLUTION: This massage cream contain 0.3-85wt.% of silicon oxide which is SiO2 and composed of sphere particles with a particle size of &lt;=3μm. Anions are ejected from the silicon oxide to neutralize the positive static electricity on the body surface or inside the body to convert to minus charge. In addition, the released anions activate the oxygen in the peripheral air. These activated oxygen or anions directly activate cells and body fluid such as blood. The silicon oxide is desirably ionized negatively and larger effect is attained as the degree of anionization becomes higher. Coupled with the pointillage, the ionization effect enables the recovery to healthy body.
FIELD: medicine, pharmacology. SUBSTANCE: invention relates to an antithrombosis agent and a method of its preparing. An antithrombosis agent consists of heparin and peptide &#34;Semaks&#34; taken at the definite ratio of components. Method of preparing an agent involves mixing the complex preparation of high-molecular heparin with regulatory peptide &#34;Semaks&#34; at weight ratio = 1:1 and incubation at 37 C for 50-60 min. Invention provides preparing the preparation showing the broad spectrum of an anticoagulating and antithrombosis properties. The preparation is used by an intranasal administration in an organism. EFFECT: enhanced effectiveness of an agent. 2 cl, 1 tbl, 4 ex
PURPOSE:A vaccine for animals comprising an oily adjuvant using both a surface active agent and liquid paraffin. CONSTITUTION:A hydrophilic oily adjuvant of water-in-oil type obtained by blending anhydrous mannitol oleic ester (molecular weight: 428, elemental ratio of C:H:O=24:44:6), a surface active agent sown by the formula, with liquid paraffin in the ratio of 1:9 is used to give a vaccine for animals. The amount of an antigen (stock solution of vaccine) to be blended wit the adjuvant is preferably 30% antigen based on 70% adjuvant. EFFECT:Only a small amount of stock solution of vaccine is used and the vaccine can be rationally produced. The viscosity of AMOE adjuvant has 1/50 the viscosity of existing Freund&#39;s adjuvant and the vaccine is extremely readily processed into emulsion and injection. The vaccine will not change for a long period (&gt;=one year) and maintains a good emulsified state. The vaccine is observed to have significant difference in terms of rise in antibody titer and sustained release compared with other vaccines.
PURPOSE: Provided is Compounds useful for the treatment of conditions and diseases which are characterized by unwanted MP activity, potent inhibitors of metalloproteases, pharmaceutical compositions comprising such inhibitors and a method of treatment for metalloprotease related maladies. CONSTITUTION: A &#34;safe and effective amount&#34; of a Formula (I) compound is an amount that is effective, to inhibit metalloproteases at the site(s) of activity, in a mammal subject. Formula (I) compound that is suitable for administration to an animal, preferably mammal subject, in a single dose, according to good medical practice. These compositions preferably contain from about 5 mg (milligrams) to about 1000 mg, more preferably from about 10 mg to about 500 mg, more preferably from about 10 mg to about 300 mg, of a Formula (I) compound. The inhibitors of the invention can be targeted to specific locations where the metalloprotease is accumulated by using targeting ligands. The compounds are relatively small, they are advantageously coupled to neutral carriers such as the conventionally used keyhole limpet hemocyanin (KLH) or serum albumin carriers.
FIELD: medicine. SUBSTANCE: method deals with treating polyposis by using H + , K + -ATPase inhibitor and glucocorticoid, if necessary. The innovation refers, also, to pharmaceutical preparation for simultaneous, separate or successive introduction at treating Widal&#39;s syndrome, and at treating asthma, as well. The innovation in question provides new method in treating nasal polyps, especially in cases when all known ways are useless. EFFECT: higher efficiency of therapy. 14 cl, 10 ex, 1 tbl
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a medical image processing apparatus for performing matching decision between pieces of collateral information without considering a slight difference.  &lt;P&gt;SOLUTION: A control unit 21 (cooperation between the control unit 21 and a matching decision program 251) acquires DICOM (Digital Imaging and Communication in Medicine) image data from an external apparatus through a communication unit 24. The control unit 21 acquires patient information that is a comparison target from a DICOM image data management DB 252. The control unit 21 compares character formats or character notations of the acquired patient information and patient information included in the collateral information of the DICOM image data acquired from the external apparatus, and decides matching between the respective pieces of the patient information. When deciding that the matching is performed, the control unit 21 registers the DICOM image data acquired from the external apparatus into the DICOM image data management DB 252, and stores them in a storage unit 25.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
The present invention relates to a multifunctional Baikuangkangtiji which is suitable for healing a human body by combining various natural minerals. The present invention is characterized in that a certain amount of jade dust, magnetite, Precambrian deterioration hot liquid type polymetallic ore, rare earth ore, late Proterozoic era shore neritic facies leuco leptite with C and S, table salt and mica are mixed and are bagged after being pulverized to obtain a finished product. The present invention is used by scalding, soaking, washing, drinking, wiping, rubbing, smearing, kneading, wearing, taking, parceling, etc. according to patients&#39; purposes. The present invention using self favorable infrared radiation effects, biologic field, magnetic effects and heat effects achieves the effects of conditioning the viscera, stretching the channels and activating vitality by the infiltration and the absorption of the skin cell membranes of a human body. The present invention has the functions of warning the loin, protecting the kidney, replenishing vital essence to tonify the kidney, dispelling cold, nourishing belly, activating blood circulation, lowering lipid, dropping pressure, nourishing skin, slimming the body, lighting weight, protecting skin, nourishing heart, whitening the skin, clearing the eyes, refreshing mind, blackening the hairs, removing splash, eliminating wrinkles, removing blain, eliminating trace, nourishing the face, etc.