anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
Intrauterine fetal growth restriction (IUGR) is an affliction of a disparaging spectrum, placental insufficiency being the major inciting pathology. The resultant fetal hypoglycemia is alleviated by intravenous hypertonic D-glucose 25-50% maternal supplements, by improving the V max  of placental substrate transfer, as per Michaelis-Menten model. Fetal normoglycemia so restored in turn surprisingly improves fetal hypoxia, hypercapnia if any, lactic acidemia, acidosis, oliguria with/without oligohydromnios, hypertriglyceridemia, and the fetal nutrient, mineral and vitamin acquisition. The list being phenomenal can only convince an inquiring reader by a biochemical sojourn into the aquatic world of the fetus, herein described. Maternal carbohydrate predominant, essential amino acids/fatty acids rich IUGR-diet incorporating maximal amounts of vitamin and minerals are highly beneficial for attainable placental V max . Transamniotic isotonic D-glucose supplement via minimally invasive ‘Suprapubic extraperitonial pelvic approach’ for amniotomy (Sumathi Paturu&#39;s technique) with a Subcutaneously Implanted Pregnancy Port (SIPP) catheter is the additional therapy advocated.
A curative for rheumatism and other complaints is produced by culturing in solid or in liquid media fluorescent microbes isolated from sea animals, e.g. cuttle fish, or fresh water animals, or sea water, extracting the active substance with distilled water containing or not antiseptics, e.g. phenol, or with an organic solvent, e.g. methanol, ethanol, butanol, benzene, or aqueous solutions thereof, or with physiological salt solution or with acid or alkali solutions, separating protein and lipoid material when present, and recovering the active substance, including a final stage of evaporating to dryness in vacuum at low temperature.  When extraction is effected by non-organic solvents, protein, amino acids and lipoid material are separated by filtration through asbestos treated with sodium silicate and magnesium silicate.  After filtration, the pH is adjusted to 2-6, the active substance is adsorbed on, say kaolin or active carbon and the adsorbate treated, e.g. with caustic soda solution at pH 8-12 to elute the active substance.  After concentration, alcohol is added to precipitate substances insoluble therein, and the filtrate is dried in vacuum at low temperature.  As an alternative to the adsorbtion procedure, silver nitrate, lead acetate, &amp;c. is added to precipitate a heavy metal salt of the active substance, which is recovered by precipitating the metal with hydrogen sulphide.  The filtrate is concentrated to dryness and the active substance dissolved in carbolic acid, alcohols, acetone, benzene, or aqueous solutions thereof.  The culture medium may be dried at low temperature and lipoid extracted with ether prior to extraction of the active substance.  Prior to or during extraction, the microbe may be destroyed by physical means, e.g. by heat or pressing, or by chemical means, using acid or alkali.
A compound of the formula &lt;IMAGE&gt; or a pharmaceutically acceptable salt thereof, wherein: G is hydroxymethylene or carbonyl; R is hydrogen or alkanoyl having from one to seven carbon atoms; R1 and R2 are each methyl or ethyl; R3 is an alkyl of from five to seven carbon atoms; m is 0 or 1; and n is 1, 2 or 3. A preferred compound is one in which m is zero, n is one or G is hydroxymethylene. Also preferred are compounds in which R1 and R2 are methyl. Additional preferred compounds include those where R is hydrogen or acetyl. A preferred compound is Z-3-(4&#39;-(dimethyl-n-hexylsilyl)-2&#39;-hydroxyphenyl)cyclohexanol. The invention further comprises pharmaceutical compositions containing these compounds. In accordance with the present invention, these compounds when administered in an effective amount to mammals are useful as CNS agents including analgesics, tranquilizers, sedatives, anticonvulsants, antidiarrheals, antiemetics and antianxiety agents.
[US4379783A]
PROBLEM TO BE SOLVED: To obtain a wrinkles improver containing a guanidine derivative having a specific structure or its acid addition salt as an active ingredient, capable of suppressing occurrence of wrinkles without impairing normal skin physiology and excellent in effect for eliminating wrinkles and having good feeling to users. SOLUTION: This wrinkles improver is obtained by using a guanidine derivative of formula I [A and B are each a 2-8C alkylene; D is a direct bond or a 1-6C alkylene; E is H, an alkyl, an aralkyl or an aryl; (m) is 1-6; (n) is 0-6; R&lt;1&gt; is H, an alkyl or (AO)m (BO)n -D-E] or formula II [(k) is 1-10; G is H, OH, COOH, sulfonic acid or phosphoric acid] or its acid addition salt. The wrinkles improver is useful as a cosmetic for preventing aging. The content of the active ingredient is preferably 0.001-50wt.%. An organic acid or its ester in an amount of 0.001-30wt.% is preferably further added to the system. A dicarboxylic acid is preferably used as the organic acid. The compound of formula I is obtained by reacting, e.g. a compound of formula III with a guanidination reagent.
PURPOSE: A composition containing Cinnamomum cassia extract, fraction thereof, trans-cinnamaldehyde isolated from the same is provided to protect dopamine neural cell damage. CONSTITUTION: A composition for preventing and treating Parkinson&#39;s disease contains Cinnamomum cassia extract as an active ingredient. The extract is obtained from branch or bark of Cinnamomum cassia using water, low alcohol of C1-C4, or mixture solvent. A composition for preventing and treating Parkinson&#39;s disease contains Cinnamomum cassia organic solvent fraction which is obtained by using organic solvent. The organic solvent is ethylacetate or butanol. A composition for preventing and treating Parkison&#39;s disease contains trans-cinnamaldehyde or pharmaceutically acceptable salt as an active ingredient.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a structure-stabilizing technique excellent in safety which can replace heretofore-known structure-stabilizing means.  &lt;P&gt;SOLUTION: A cream-like detergent containing a fatty acid potassium salt is caused to contain a polyoxyethylene branched fatty acid glyceryl ester as a detergent component. An isostearic acid residue is particularly preferable as the branched fatty acid residue. In a preferable form, the detergent component is a combination of the polyoxyethylene monobranched fatty acid glyceryl ester and a polyoxyethylene tribranched fatty acid glyceryl ester. In a particularly preferable form, the detergent component is a combination of the glyceryl polyoxyethylene(20)triisostearate and a glyceryl polyoxyethylene(20)monoisostearate.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a new osteogenic agent.  &lt;P&gt;SOLUTION: The bone around a site neighboring a bone tissue can be easily made by sustainedly releasing statin at the site. The osteogenic agent comprises 1. preparing a topically sustainedly releasing preparation from the statin or a derivative thereof, and 2. having the component of a carrier for the topically sustainedly releasing preparation selected from (1) calcium sulfate, (2) calcium phosphate and (3) calcium carbonate. The statin or the derivative thereof is topically administered. The topical administration comprises directly filling the preparation into a bone-deficient site such as a tooth-extracted recess and a cavity of pustule, a fracture site, the surrounding of an artificial implant such as an artificial dental root, and an absorbed alveolar bone site.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
FIELD: medicine. ^ SUBSTANCE: invention relates to field of pharmacy, in particular to phytotherapy, and can be applied for treatment of drug hepatitis. Medication represents herbal mixture, including 29 herbs: herbal part of woodland strawberry, herbal part of common dandelion, inflorescences of pineapple weed, leaves of stinging nettle, inflorescences of tansy, inflorescences of pot marigold, fruits of common juniper, peppermint leaves, herbal part of St John&#39;s wort. Medication additionally contains: lime tree flowers, herbal part of heartsease, herbal part of Centaurium, flax seeds, dill seeds, burdock root, herbal part of common chicory, herbal part of common knotgrass, collective fruits of common hop, herbal part of cornflower, leaves of cowberries, leaves of Arctostaphylus, corn stigma, herbal part of immortelle, root and rhizome of Acorus, herbal part of Menyanthes, garden angelica root, herbal part of yellow sweet clover, Inula root, herbal part of common horsetail. ^ EFFECT: mixture reduces terms of hepatitis treatment, as well as improves clinico-laboratory indices due to normalisation of liver function tests and functional state of liver. ^ 4 ex, 2 tbl
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an anticancer agent having safe and excellent anticancer activity and producible by a simplified production process, and to provide a food and drink.  &lt;P&gt;SOLUTION: The anticancer agent contains a cultured product obtained by culturing a mycelium of Basidiomycete and/or Ascomycete in a medium prepared from a raw material containing algae, or an extract prepared from the cultured product as an active ingredient. Chlorella and/or Spirulina is preferable as the algae, and shiitake mushroom or Ganoderma lucidum is preferable as the Basidiomycete and/or the Ascomycete. The cultured product is preferably collected as an extract obtained by autolysis by an enzyme contained in the mycelium of the Basidiomycete and/or the Ascomycete. The anticancer agent can be added to various kinds of foods and drinks.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a meningococcal vaccine.  &lt;P&gt;SOLUTION: The invention relates to a vaccinal composition or immunogenic composition comprising a mixture of a meningococcal capsular polysaccharide, an adjuvant amount of interleukin-12 and an aqueous suspension of alum, and optionally comprising a physiologically acceptable vehicle. The interleukin-12 is adsorbed onto the suspension of alum. The alum is aluminum hydroxide or aluminum phosphate. The meningococcal capsular polysaccharide may be conjugated to a carrier molecule such as tetanus toxin, diphtheria toxin, pertussis toxin and non-toxic variants thereof.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PCT No. PCT/AU90/00025 Sec. 371 Date Jul. 3, 1991 Sec. 102(e) Date Jul. 3, 1991 PCT Filed Jan. 29, 1990 PCT Pub. No. WO90/08783 PCT Pub. Date Aug. 9, 1990.The present invention provides a membrane the conductivity of which is dependent on the presence or absence of an analyte. The membrane comprises a closely packed array of self-assembling amphiphilic molecules and two ionophore components. A receptor molecule reactive with the analyte is provided on one of the ionophore components. The binding of the analyte to the receptor molecule causes a change in the relationship between the ionophore components such that the flow of ion across the membrane is prevented or allowed. The ionophore components are preferably selected from the group consisting of amphotericin B, gramicidin A monomers and combinations thereof, with gramicidin A monomers being particularly preferred. The present invention also provides a membrane including receptors directed against the Fc region of antibodies. These receptors are preferably derived from polyclonal antibodies. These membranes provide a &#34;generic&#34; surface which will bind antibodies in a manner such that the antigen binding regions of the antibody are not hindered. The present invention further provides a device adapted for implantation in a mammalian body, the device being characterized in that it is coated with a membrane comprising a closely packed array of self-assembling amphiphilic molecules and receptor molecules, the receptor molecules being such that the attachment of specific cells to the membrane is enhanced or avoided. It is particularly preferred that the receptor molecules are directed against fibronectin, vitronectin, endothelial cells, or epithelial cells. It is further preferred that the membrane coating the device also includes a plurality of ion channels such as gramicidin.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a communication terminal with high operability allowing an aged person to easily input the situation of the person&#39;s own medical treatment from a remote place; a processing system for presenting indexes for evaluating the person&#39;s condition based on the primary processing of the input data; and a method of processing thereof.  &lt;P&gt;SOLUTION: The remote nursing system is constituted by a patient terminal, a data processing main server and a nurse terminal, all of which are connected to each other. The patient terminal is for a patient undergoing home oxygen therapy to periodically transmit measured data and answers to a doctor&#39;s questions at home by the input operation of a touch panel while undergoing the medical treatment. The data processing main server receives the transmitted measured data and answers to the doctor&#39;s questions, tallies and primarily analyzes the received data, stores the data by patient, and presents the result of the tally and primary analysis to a nurse in charge and a doctors in such a way as can be browsed. The nurse terminal is for the nurse in charge browsing the data to transmit the findings for nursing for the situation of the medical treatment of the patient and to additionally write in a recording file for each patient in the data processing main server in a remote nursing monitor data center.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
PURPOSE: To provide an agent for preventing or inhibiting the progress of dental caries and containing the extract of KOBOKU (bark of Magnolia officinalis REHD. et WILS.), OREN (rhizome of Coptis chinensis FRANCH.) etc. or magnolol and honokiol which are the active components of the above extract.  
     CONSTITUTION: The objective agent contains the extract of KOBOKU, OREN, GOBAISHI (gall of Rhus chinensis MILL), GENNOSHOKO (whole grass of Geranium thunbergii SIEB. et ZUCC.), OBAKU (bark of Phellodendron amurense RUPR.), etc. and/or their active components (e.g. magnolol or formula I,  honokiol of formula II, berberine, etc.). The agent inhibits remarkably the  growth of Streptomyces mutans which is a cariogenic bacterium having the  strongest cariogenicity. The agent has somewhat milder activity than erythromycin, and lower side effects than antibiotic substances, and is suitable for administration for a long period. It also exhibits remarkable effect at a low concentration in a short time. Administered directly in the oral cavity, or by mixing with  tooth paste, or in the form of troche or sublingual tablet. 
     COPYRIGHT: (C)1982,JPO&amp;Japio
PURPOSE:To obtain a herb medicine in a solid form by packaging a herb medicine compressed with a certain pressure with a synthetic resin film. CONSTITUTION:One of herb medicines which are cut into pieces measuring 5-8mm such as geranium herb or Japanese angelica root or a formulated herb medicine such as KAKKONTO (decoction of Kudzu) is molded with a compression molding press under 170-230kg/cm&lt;2&gt; and packed with a synthetic resin film (for example, a nylon-polyethylene-vinylidene chloride laminated film) to give a herb medicine to be used as a decoction preparation. The preparation is made easily foldable by forming creases 3 every dose a day or administration and packaged. It may be formed into disks corresponding to every dose. Since the herb medicines are compressed, the bulk volume is reduced and the storage, transportation and display on the shelf become advantageous and convenient. Further, the quality is kept good.
To provide a compound capable of obtaining a labeled biomaterial exhibiting excellent fluorescence intensity in a solution and a membrane state, and a labeled biomaterial.SOLUTION: There are provided a compound represented by the following general formula (1) and a labeled biomaterial using the same. RH-L1-Q general formula (1) (wherein, RH represents a hydrophilic group. Q represents a carboxy group, a substituent capable of binding to a biomaterial or a substituent capable of binding to a solid support. L1 is a linking group for linking RH and Q and represents a divalent linking group that is a combination of one or two more of each group of an alkylene group, an alkenylene group, an alkynylene group, a divalent ring group, -O-, &gt;NRa1, &gt;C=O, &gt;S=O, -S(=O)2- and &gt;P(=O)ORa2. Ra1 and Ra2 represent a hydrogen atom or a monovalent substituent. Provided that L1 has at least one group containing a phosphor part as a substituent.SELECTED DRAWING: None
Detergent compositions having therapeutic properties comprise (1) one or more anionic surface-active agents, and (2) an aqueous suspension of a selenium sulphide complex of a carboxypolymethylene compound. The carboxypolymethylenes are cross-linked copolymers of mono-olefinically unsaturated monomers containing at least 25% of an acid, e.g. acrylic acid, with up to 10% of a poly-unsaturated cross-linking agent.  Suitable components (1) are alkaryl sulphonates and alkyl sulphates. Other components of the compositions mentioned are coal tar extract, water-soluble alkaline substances, perfumes, and preservatives. The compositions may be prepared, for example, by adding the suspension (2) to an aqueous solution or dispersion of the component (1).ALSO:A suspension of a complex of selenium sulphide and a high molecular weight carboxypolymethylene compound in an aqueous medium is preferably such that the complex contains 50 to 97% by weight of selenium sulphide and 35 to 15% by weight of said carboxypolymethylene compound.  The carboxypolymethylene compound, which is a cross-linked copolymer of at least 25% of an olefinically unsaturated carboxylic acid and up to 10% of a polyunsaturated cross-linking agent, particularly of acrylic acid with polyalkenyl polyethers of polyhydric alcohols, as specified in U.S.A. Patent 2,798,053, in which further exemplified comonomers include styrene, vinyl acetate, divinyl ether, maleic anhydride, N-methylacrylamide and other vinyl ethers, may be unneutralized, partially neutralized or wholly neutralized.  The suspension may be prepared by (1) grinding selenium sulphide and the carboxypolymethylene compound together until the selenium sulphide particles are of the desired size, preferably 1 to 25 microns, and then suspending the resulting powder in an aqueous medium or (2) grinding selenium sulphide and the carboxypolymethylene compound together in the presence of the aqueous medium.  Therepeutic compositions comprising the above suspension of a selenium sulphidecarboxypolymethylene complex in an aqueous medium, preferably water, together with one or more anionic surface-active agents, the pH of the composition preferably being adjusted to 4.5 to 7.0, may be prepared by adding the suspension to an aqueous solution dispersion of the anionic wetting agent.  Other active ingredients such as a coal tar extract, may be added as well as perfumes &amp;c.  In the examples shampoo compositions are formed.ALSO:Therapeutic compositions comprise (1) an aqueous suspension of a selenium sulphide complex of a carboxypolymethylene compound, and (2) one or more anionic surface active agents.  The carboxypolymethylenes are cross-linked copolymers of mono-olefinically unsaturated monomers containing at least 25% of an acid, e.g. acrylic acid, with up to 10% of a polyunsaturated cross-linking agent.  Suitable components (2) are alkaryl sulphonates and alkyl sulphates.  Other components of the compositions mentioned are coal tar extract, water-soluble alkaline substances, perfumes and preservatives.  The compositions may be prepared, for example, by adding the suspension (1) to an aqueous solution or dispersion of component (2).
The present invention belongs to the field of pharmacy, which more specifically relates to a compound Chinese medicinal preparation for treating abortion caused by abnormal immune regulation and/or incretion function deficiency. The present invention uses pilose asiabell root, dodder seed, Chinese taxillus twig, eucommia bark, white atractylodes rhizome, white peony root, baical skullcap root, perilla stem, etc. as raw medicinal materials to prepare the compound preparation for treating spontaneous abortion according to the Chinese medicine theories of &#39;etiology and pathogenesis&#39;, &#39;determining the treatment based on differentiation of symptoms and signs&#39; and &#39;kidney controlling reproduction&#39;. The successful rate of tocolysis can reach 90%. The present invention performs the tocolysis function by regulating the protective immunity function of foetuses and improving the level of endocrine hormone, and is beneficial to the growth and development of the foetuses. The present invention can be applied to all stages of gestational periods, and can be taken for a long time without obvious side effect.
The earliest lesion of atherosclerosis is development of the fatty streak lesions which contain lipid-laden macrophages and lipid-laden smooth muscle cells. Macrophages do not take up native low density lipoprotein (LDL) but do take up modified, i.e., acetylated LDL or oxidized LDL via acetyl-LDL or &#34;scavenger&#34; receptors to form the foam cells of atherosclerotic plaque. Arterial smooth muscle cells generate superoxide and oxidize LDL in the presence of micromolar concentrations of Cu+2 or Fe+2. The way LDL can be modified by endothelial cells can be mimicked in vitro by incubation of the lipoprotein in the presence of CuCl2. The compounds of this invention inhibit copper mediated oxidation of LDL in vitro and are thus useful in the prophylaxis and treatment of clinical conditions for which inhibition of the oxidative modification of lipids is indicated, for example, atherosclerosis. The compounds of this invention are represented by the formula 1 below    &lt;IMAGE&gt;  I  wherein: R1 is hydrogen, C1-C6 alkyl, phenyl or naphthyl; R2 is OH, NH2, OR3, or NHCO2R4 wherein R3 and R4 are independently selected from C1-C6 alkyl, phenyl or naphthyl; or a pharmaceutically acceptable salt thereof.
PURPOSE:To obtain an anti-inflammatory drug suppressing side effects related to gastrointestinal disorder, containing a melanin-based substance obtained from ink of cuttlefish or octopus. CONSTITUTION:Ink of cuttlefish or octopus is incorporated with an alkalizing agent such as caustic soda or potash soda, adjusted to pH6-12, homogenized by a homogenizer, filtered by filter cloth, dialyzed and lyophilized to give a melanin-based substance. The substance is pharmaceutically manufactured by a conventional procedure as it is or blended with a carrier and an excipient for proper preparation and pharmaceutically manufacture to give the aimed substance. The substance can be made into a dosage form such as powder, granule, tablet, capsule or injection and a dose is 50-500mg/day per adult. Properties of the melanin-based substance; black amorphous powder; solubility; slightly soluble in water and insoluble in ethanol, ethyl acetate and benzene; melting point: &gt;=300 deg.C; elemental analysis value: C 47-50%, H 3-4%, O 38-41%, N 8-9% and ash 0.06-0.08%; molecular weight: mixture of substance having 25,000mol.wt. and substance having &gt;=160,000.