anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PURPOSE:To obtain a vascular hyperplasia suppressor and a smooth muscle cell migration suppressor each containing a 7-thiaprostaglandin E1 compound as an active ingredient. CONSTITUTION:These agents contain each a compound of the formula (R&lt;1&gt; is H, an alkyl or a cation: R&lt;2&gt; is H or methl; R&lt;3&gt; is an alkyl or a cycloalkyl; (n) is 0 or 1; * is an asymmetric C). e.g. (17R)-17,20-dimethyl-7-thiaprostaglandin E1 methyl ester as an active ingredient. This compound is useful as a suppressor for vascular hyperplasia or obstruction mainly caused by migration or proliferation of a vascular smooth muscle cell after various angioplasties such as percutaneous coronary artery plastic operation, artery bypass ans grafting of organs. The administratoin of the compound is preferably per oral or intravenous and the daily does of the 7-thaipristaglandin E1 compound is 1 mug-1 mg/adult.
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to dentistry, and can be used for treating chronic generalized periodontitis. For this purpose patient is removed with ultrasound apparatus solid and soft dental deposits, with subsequent polishing of teeth. Periodontal pockets are washed with diluted 1:2,000 Vagothyl solution. Marker &#34;HELBO BLUE Photosensitaiser&#34; is placed on the affected periodontal pocket for 1–3 minutes. Then liquid is washed from periodontal pockets and exposed to therapeutic diode laser &#34;HELBO&#34; 2075 F/Theralite&#34; with wave length 670–690 nm and power density 75 mWt/cmfor 1–2 minutes. After the laser exposure on the affected periodontium, a gingival dressing is applied for 20 minutes from a mixture of substances kneaded by a spatula on a glass ex tempore for 1–2 minutes to a consistence of thick sour cream consisting of 2 g of acetylsalicylic ointment, 2 g of Argosulfan ointment, 2 g oflomelid ointment, 2 g of aqueous dentine, 2 g of zinc oxide, and one tablet of trichopol pre-ground.EFFECT: method provides high therapeutic effect and prolonged remission, reduced treatment period.1 cl
PURPOSE:The titled remedy, containing a dithiol derivative or a salt thereof as an active constituent, having specific promoting action on the synthesis of proteins, and capable of improving the lipid metabolism without directly affecting the synthesis of cholesterol, and useful for treating hepatitis, etc. CONSTITUTION:A remedy for hepatic diseases containing a dithiol derivative of the formula (R&lt;1&gt; and R&lt;2&gt; are lower alkyl) or a salt thereof as an active constituent. The remedy can be administered by either one of the oral and parenteral routes, but usually is administered by the oral route. Preferably, the daily dose thereof is 12.5-100mg/kg by the oral administration for humans, and 12.5- 50mg/kg by the parenteral administration. In the case of an animal as an object, the daily dose within 12.5-200mg/kg body weight range is effective. A typical compound of the active constituent of the formula is disodium 2,2-bis(isopropoxycarbonyl)ethylene-1,1-dithiolate, etc.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a dry type fiber web for wiping a body, which eliminates malodor, has excellent ability to absorb a liquid such as body fluid in use and heat absorption property, and has a good texture.  &lt;P&gt;SOLUTION: In the dry type fiber web for wiping the body, 100 pts. mass of a hydrophilic fiber web having a basis weight of 15-50 g/m&lt;SP&gt;2&lt;/SP&gt;is impregnated with 1-80 pts. mass of a dispersion liquid prepared by adding 10-300 pts. mass of sugar alcohol powder having a particle diameter of 0.01-300 μm to 100 pts. mass of a glycol. The fiber web can contain a transdermal drug or skin barrier such as an ultraviolet screen.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
The present invention relates to a method for predicting neurodegenerative decline and/or its severity for a patient, especially of cognitive impairment (CI). Strokes and Parkinson&#39;s disease are frequently associated with occurrence of long-term cognitive impairment or dementia with still incompletely resolved mechanisms. The discovery of diagnostic and predictive biomarkers thus remains a major challenge. The method of the invention uses radiomics corresponding to texture features extracted from a plurality of previously-acquired medical brain images and correlated with previously-acquired clinical and/or biological data. A classifier is trained beforehand for learning these radiomics, and then operated on radiomics computed from at least one brain image of a patient to generate a score representative of its risks of neurodegenerative decline. By applying this method on a cohort of 160 MCI and non-MCI patients, the inventors show that MCI patients could be early predicted with a mean accuracy of 88%. In the same way, the method was able to discriminate very early stages of cognitive decline in a Parkinson&#39;s disease population of 100 patients.
PROBLEM TO BE SOLVED: To shorten a treating time while suppressing the generation of lump particles. SOLUTION: One or plural spray nozzles 8 for spraying a spray soln. in mist-like by spray air are provided in a treating chamber 4a. The spray nozzle 8, enables a high volume soln. injection of &gt;=700 NL/min spray air flow rate and 360 g/min spray soln. flow rate per one spray nozzle. The treating time per one batch can be shortened compared with the conventional method while suppressing the generation of the lump particles by executing high concn. soln. injection and the high volume soln. injection by using the high volume spray nozzle 8.
An inclusion complex comprising coenzyme Q10 and β-cyclodextrin, its manner of preparation, and its use in products, such as, for example, pharmaceuticals, cosmetics, and aliments is disclosed. β-cyclodextrin is dissolved in water at a temperature elevated above room temperature, such as, for example, between 55° C. and water&#39;s boiling temperature. While stirring the β-cyclodextrin-water solution, coenzyme Q10 is added either in a solid form or a solution. Stirring is continued at the evaluated temperature and, then, either at room temperature or a temperature lower than room temperature. The complex enhances the water solubility of the coenzyme Q10 significantly. Also, the complex improves the bioavailability and prophylactic or therapeutical effectiveness of coenzyme Q10. Thus, the inclusion complex solves the problem of poor water-solubility of coenzyme Q10 that renders difficult a manufacture of effective preparations with this enzyme on a non-lipophilic base, as well as its addition to various alimentary, cosmetic, and/or pharmaceutical products.
The invention discloses a preparation technology of a green hata Beta lymphocyte stimulator (BAFF) gene and a protein and relates to the technology of cloning, expression, protein purification and activity identification of the green hata BAFF gene. The overall length cDNA (complementary deoxyribonucleic acid) of green hata BAFF is obtained through RT-PCR (Reverse Transcription-Polymerase Chain Reaction) and RACE (Rapid-Amplification of cDNA Ends) technologies. The BAFF has the sequence shown in SEQ ID NO.1, and the protein encoded by a gene CDS open reading frame has the amino acid sequence shown in SEQ ID NO. 2. An extracellular functional zone can be fusibly linked to a pET28a pronucleus plasmid and be transferred to an escherichia coli BL21 (DE3) to be expressed, and an obtained protein is purified by an Ni&lt;+&gt;-NTA column to obtain a recombinant protein His6-EasBAFF. Experiments prove that the fusion protein is capable of obviously promoting survival of green hata lymphocytes and Beta lymphocytes of a mouse.
Process for the obtaining of substitute 4-fluorophenil-piperidins in position 3 and of their physiologically compatible acid addition salts, of formula (I), where r is hydrogen or alcohil c &lt;003&gt;; and the atom of fluor can occupy any available position. It consists of the reaction of 3,4-methylendioxypenol with a derivative of formula (II) pyridine, where r is the same as in formula (I), and x is halogen, group ester or hydroxyl. When x is chlorine or ester group, the reaction is carried out in methanol, in the presence of sodium at a temperature between 0ºc and lade reflux. When x is hydroxyl the reaction is carried out through a coupling reagent at a temperature between 160ºc and 180ºc. These compounds have pharmacological applications as antidepressive and anti-perkinsonian agents. (Machine-translation by Google Translate, not legally binding)
A novel composite for internal application within wounds, incisions, and the like, for the prevention of biofilm growth therein is provided. Such a composite includes an antibiotic introduced within a sponge-like chitosan delivery product with electrically conductive nanomaterials present. Such a delivery product is also lyophilized subsequent to nanomaterial introduction but prior to antibiotic inclusion. The inventive lyophilized composite permits delivery of needed antibiotics internally within a patient with the simultaneous exposure to a sufficiently strong electrical current to permit a synergistic effect of increased antibiotic efficacy. In such a manner, relatively low amounts of antibiotic may be utilized to reduce the propensity of biofilm formation and/or growth within a wound or incision, or on the surface of an implant. Additionally, the lyophilized chitosan/nanomaterial composite allows for a maximum amount of antibiotic to be introduced with maximum elution therefrom as well. Lastly, the chitosan degrades over time within the subject&#39;s body, thereby avoiding any further invasive removal procedures. The method of such a manner of delivering improved antibiotic efficacy for biofilm prevention is encompassed within this invention as well.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a human glucagon-like peptide-1(GLP-1) derivative with a protracted profile of action.  &lt;P&gt;SOLUTION: The GLP-1 derivative is such that a lipophilic substituent such as an alkyl or ω-carboxylic acid group is added to the N-terminated or C-terminated amino acid residue. An analogue of this derivative wherein part of the amino acid sequence in this derivative is transformed is also provided. In this derivative, a 2nd lipophilic substituent may be bound to an amino acid residue other than the terminal. The derivative and the analogue each have a more protracted profile of action than the parent GLP-1(7-37).  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
Systems and techniques that facilitate background monitoring of eye health are provided. In various embodiments, a system can comprise a sensor component of a device. In various aspects, the sensor component can detect one or more physical characteristics associated with an entity. In various embodiments, the system can further comprise a diagnostic component of the device. In various instances, the diagnostic component can estimate in a background of the device a health condition of an eye of the entity based on the one or more physical characteristics. In various cases, estimating the health condition in the background of the device can facilitate real-time monitoring of the eye health of the entity without interrupting the entity&#39;s normal use of the device.
&lt;P&gt;PROBLEM TO BE SOLVED: To minimize radiation of electromagnetic waves when making a radio communication between a terminal and an apparatus.  &lt;P&gt;SOLUTION: In this health control system, transmission and reception means 100 and 200 where a communication distance can be controlled to two or more stages (e.g. long distance communication of several tens meters and short distance communication of one meter and several tens centimeters) are provided respectively at the terminal 1000 and the apparatus 2000. When transmission is instructed by a transmission instruction means (transmission start button 120) provided at the terminal 1000, biological information obtained by a biological information obtaining means 130 provided at the terminal 1000 is transmitted through the long distance communication. When a transmission request signal sent through short distance communication by the apparatus 2000 is received by the terminal 1000, the biological information is transmitted from the terminal 1000 to the apparatus 2000 through the short distance communication.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
PURPOSE:A composition useful as toothpaste, filler kiss paste, etc. having proper polishing properties by itself, showing improved luster imparting effect on the teeth, having proper polishing power, cleaning power, obtained by blending an oral cavity composition with anhydrous alpha-alumina having a specific crystal size. CONSTITUTION:An oral cavity composition is blended with alpha-alumina anhydride having 0.1-2.5mum average crystal size. alpha-Alumina comprising particles having 0.1-4.5mum secondary aggregation particle diameters, containing no particles having &gt;=5mum secondary aggregation particle diameter, is preferably used as the alpha-alumina anhydride. The composition for oral cavity obtained reduces surely scratch, has no feeling of roughness to the tongue, and has good feeling in use. An amount of alpha-alumina anhydride blended is 0.1-60wt% based on total amount of the composition, and especially 0.1-10wt% when it is mixed with another polishing material. EFFECT:Even if the alpha-alumina anhydride is mixed with a polishing agent having high polishing power such as Al(OH)3, calcium hydrogenphosphate containing no hydrate, polishing silica, etc., it can make the teeth smooth without damaging them.
NEW MATERIAL:The bisbenzylisoquinoline derivative of formula I (R is 3-10C acyl or p-nitrobenzoyl) or its acid addition salt. EXAMPLE:12&#39;-O-propionylcepharanoline. USE:Useful as a carcinostatic agent. PREPARATION:The compound of formula I can be produced by reacting a compound of formula II (e.g. cepharanoline) with a compound of formula III (X is halogen or OH) or with a compound of formula IV. In the case of reacting the compound of formula II with the compound of formula III wherein X is halogen atom or with the compound of formula IV, the reaction is preferably carried out in a basic solvent such as pyridine. When the group X in the compound of formula III is hydroxyl group, the reaction is preferably carried out in a solvent in the presence of a binder.
There is provided a herpes virus vaccine produced in in the seeds of a cereal crop and a method of producing the vaccine. The method comprises: a) obtaining a nucleic acid sequence encoding a herpes virus antigen; b) introducing the nucleic acid sequence into cereal plant tissue competent to form seeds; c) permitting said cereal plant tissue to develop; and, d) directing preferential expression of the antigen encoded by the nucleic acid sequence in seeds formed by the cereal plant tissue. Herpes viruses antigens of particular interest include all or antigenic portions of gB (from human cytomegalovirus (&#34;HCMV&#34;)), gH (from HCMV), and gD (from herpes simplex virus 1 or 2), as well as antigens from Epstein Barr virus and varicello-zoster virus-8. Envelope glycoproteins from herpes viruses are antigens of interest. Cereal crops of particular interest include rice, wheat, oats, barley, and corn. Vaccines produced according to the invention are very stable and may be administered by a variety of routes, including injection and contact with mucosal membranes, such as by oral administration in purified or unpurified form.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide method for rapidly and efficiently preparing protein-polymer conjugates.  &lt;P&gt;SOLUTION: The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the present invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB 1. The present invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide muscle cells and the use of the muscle cells in cardiac repair.  &lt;P&gt;SOLUTION: Muscle cells and methods for using the muscle cells are provided. In one embodiment, the invention provides transplantable skeletal muscle cell compositions and their methods of use. In one embodiment, the muscle cells can be transplanted into patients having disorders characterized by insufficient cardiac function, (e.g., congestive heart failure), in a subject by administering the skeletal myoblasts to the subject. The muscle cells can be autologous, allogeneic, or xenogeneic to the recipient.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
PURPOSE:To obtain a member for external use having improved uniformity and releasability of a chemical without depositing a water-soluble chemical, by coating the surface of a support material with a mixture containing an aqueous or alcoholic solution of the water-soluble chemical dissolved in a solution of a specific adhesive high polymer. CONSTITUTION:An aqueous and/or alcoholic solution of a water-soluble chemical, e.g. &#39;&#39;Clonidine hydrochloride&#39;&#39; or quinidine hydrochloride, is incorporated with and dissolved uniformly in a solution of an adhesive high polymer consisting essentially of an alkyl acrylate or methacrylate, preferably having &lt;=10wt/ wt%/24hr water absorption at 25 deg.C, and the resultant mixture is then applied onto the surface of a support material, e.g. a plastic film, nonwoven fabric or cloth. 0.5-20wt%, expressed in terms of solid, chemical is suitably added to the high polymer solution. A functional monomer, e.g. acrylic or methacylic acid, is copolymerized with the above-mentioned adhesive high polymer to impart more cohesiveness, and a hydrophilic alkoxyalkyl acrylate is copolymerized therewith to improve the compatibility with the chemical.
PURPOSE:To obtain the titled preparation capable of controlling release of drug, by dissolving a water-soluble drug having a specific molecular weight and polyvinyl alcohol in water, freezing and thawing. CONSTITUTION:0.05-1.0wt% based on the total amounts of a water-soluble drug having 200-1,000mol.wt., preferably clonidine hydrochloride, dibucaine hydrochloride, etc., having 200-500mol.wt. and 10-20wt% based on the total amounts of polyvinyl alcohol are dissolved in water and operation of freezing and thawing the aqueous solution is carried out once or more to give drug- containing polyvinyl alcohol hydrogel. An endermic absorption preparation containing the hydrogel. The preparation controls release of the drug by changing hardening of the hydrogel. The polyvinyl alcohol has high saponification degree and has preferably &gt;=97 saponification degree. The hydrogel has different physical properties such as modulus of elasticity of storage, etc., depending upon grade of polyvinyl alcohol and difference in freezing and thawing operation.
PURPOSE:A material for releasing a volatile substance for a long time without causing change in quality, comprising sodium polyacrylate, a compound containing an epoxy group in a molecule, a cationic surface active agent, a volatile substance and water, containing the volatile substance in an emulsified state, prepared at room temperature. CONSTITUTION:A material for slow releasing a volatile substance, comprising sodium polyacrylate, a compound (e.g., polyethylene glycol diglycidyl ether, ethylene glycol diglydidyl ether, etc.) having at least one epoxy group in a molecule, a cationic surface active agent (preferably, benzalkonium chloride, etc.), a volatile substance and water, wherein the volatile substance is emulsified. The amount of water based on the material is 40-95wt%, the amount of the epoxy compound is 0.01-5wt%, and the amount of the volatile compound is &lt;= about 30wt%. The weight ratio of sodium polyacrylate to the volatile substance is preferably (0.2-8):1.
1453198 Phenolic disinfectant composition COALITE &amp; CHEMICAL PRODUCTS Ltd 21 Jan 1974 [23 Jan 1973] 3435/73 Heading A5E A disinfectant composition comprises an aqueous solution of a phenolic component and a surface active component, the phenolic component comprising one or more alkylphenols together with one or both of an aralkyl halophenol and an arylphenol and the surface active component comprising an anionic non- soap surface active agent which is one or more of a secondary alcohol sulphate, a salt of a sulphate of a C 8 -C 18  fatty alcohol ethoxylate and an alkaryl sulphonate. The composition remains clear on dilution with tap water. Typical components are xylenols (e.g. from a tar acid fraction), o-benzyl-p-chlorophenol, ophenyl phenol, sodium lauryl ether sulphate and sodium dodecylbenzene sulphonate. Optional ingredients are soaps (e.g. castor oil soap), and water-miscible alcohols such as isopropanol and methylated spirit.
NEW MATERIAL:5-Nitro-4-trifluoromethylthiazole derivative of formula I (X is halogen, lower alkyl, trifluoromethyl or trifluoromethoxy; m is 0 or 1-2; n is 0 or 2). EXAMPLE:2-(Phenylthio)-5-nitro-4-(trifluoromethyl)thiazole. USE:A fubngicide. Useful especially as an agent effective to the pathogen of human body such as candidasis, trichomoniasis, and athlete&#39;s foot, and to the blight of agricultural and horticultural plants. PREPARATION:The objective compound of formula I can be prepared by reacting 5-nitro-4-trifluoromethyl-2-halogenothiazole of formula II (Y is halogen) with the compound of formula III (Z is SH or SO2Na). The starting compound of formula II is also novel, and can be synthesized e.g. by reacting 2-amino-5- nitro-4-trifluoromethylthiazole with a halogenation agent.
Over time, cultured mammalian cells aggregate into an artificial tissue with 10% homologous serum and nicotinamide. Neonatal porcine islets alone have a SGS index of 4.6. Co-culture with neonatal porcine Sertoli cells formed free-floating islet-like structures, 300-600 microns in diameter (SGS index 21). Basal secretion of insulin remains high for islets in a heavily confluent mixed cell culture. Re-seeded cultures were very responsive to glucose (SGS index 21.8). Co-culture with fibroblasts also provides a high SGS index, permitting use of the recipient&#39;s fibroblast line as support/trophic cells for an xenotransplantable graft, as for treatment of diabetes.
Automated diagnosis archetypes based on a complete list of library of medical illnesses are used dynamically to help prioritize health data that is relevant to a physician&#39;s medical diagnosis for a patient. A super plurality of diagnoses patient archetypes are narrowed to match a patient profile based on information collected from different sources. Based on dynamic physician&#39;s diagnosis, the patient profile is mapped to a subset of plurality of patient archetypes. An automated agent is employed to customize a user interface to emphasize order selections to support eliminating a false positive in the proper subset of the plurality of patient persons, a false negative in the plurality of patient archetypes, or to increase a predicted applicability of a set of patient archetypes to the patient profile. The subset of patient archetypes ranking is updated based on received order results. A confirmed dynamic physician diagnosis is made available.