anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
A three-part method of cleaning a user&#39;s teeth and/or gums is disclosed. First, a user applies a tonic of essential oils to the user&#39;s teeth and/or gums by either brushing, rubbing, rinsing and/or flossing with the tonic thereby destroying harmful bacteria. Second, the user brushes with a toothpaste having nano-hydroxyapatite being particles of 50 nanometers or smaller. The nano-hydroxyapatite is absorbed into the surface opening inside dentinal tubules of the teeth. Third, the user seeds their mouth with an oral probiotic having beneficial bacteria. The third step must come after both the first and second steps.
Novel 6-methylene tetracycline derivatives of the general formula &lt;FORM:1108310/C2/1&gt; wherein X is H or Cl, B is H or Cl and X1 is H or OH, X and X1 being H when B is Cl, and R is amino, o -carboxy (lower, i.e. up to 6 carbon atoms) alkylamino, o -amino-o -carboxy (lower) alkylamino, o  - carboxamido (lower) alkylamino, o -amino-o -carboxamido (lower) alkyl amino or NR1R2 wherein R1 is alkyl of 1-17 carbon atoms, benzyl, phenethyl, cyclohexyl, hydroxyalkyl of 2-4 carbon atoms, o -amino (lower) alkyl, o  (lower) dialkylamino (lower) alkyl; R2 is H or R1; R1 and R2 in combination with the amino group are piperidino, pyrrolidino, morpholino, piperazino, N - methylpiperazino, 2,6 - dimethylmorpholino, N - (b -hydroxyethyl) piperazino or &lt;FORM:1108310/C2/2&gt; and their acid addition and base salts are prepared by reacting a compound of formula &lt;FORM:1108310/C2/3&gt; wherein X, B and X1 are as above defined either with a compound having the formula ZR or its acid addition salt, in which R is as above defined, and Z is H or H2NCH2- in the presence of formaldehyde or paraformaldehyde or, with an addition product of formaldehyde or paraformaldehyde and the compound ZR, and, if desired, forming an acid or a base salt of the product with an inorganic or organic acid or base.  The reaction may be carried out in an aqueous medium to which a water-soluble organic solvent may be added at a temperature from 0 DEG  to 30 DEG  C., the reactants being present in equimolar proportions.  Salts of the tetracyclines may be formed with HCl, H2SO4, H3PO4, CH3CO2H, butyric, palmitic, oleic, citric, gluconic, lactic, tartaric, ascorbic or pantothenic acids, penicillins, succinic half ester of D-(-)-threo-2-dichloroacetamino-1-p-nitrophenyl-1,3-propanediol, phytic and maleic acids and also with inorganic or organic bases e.g. alkali metal, alkaline earth metal, ammonium or organic amine salts. The novel 6-demethylene tetracycline derivatives of general Formula I and salts thereof may be formulated into pharmaceutical compositions. Reference has been directed by the Comptroller to Specification 995,031.
An enhancer of immunological functions is in the form of a composition comprising powdered  Lactobacillus brevis  subsp.  coagulans . The powdered  Lactobacillus brevis  subsp  coagulans  may comprise 2 × 10&#39; - 5 × 10¹⁰ of bacteria per 1 g and may be formed into a powder, tablet, capsule or granulated power. The  Lactobacillus brevis  subsp.  coagulans  may be obtained from  Brassica japonica  var.  Suigukina  fermented by  Lactobacillus .
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a plaster that maintains excellent percutaneous absorption of tulobuterol over a long period and can stably be applied to skin over the long period with slight skin irritation.  &lt;P&gt;SOLUTION: The plaster is provided with a medicated layer on one surface of a support. The medicated layer comprises 1-30 wt.% of a resolvent, 40-98 wt.% of a pressure-sensitive adhesive and the tulobuterol. The resolvent comprises an aliphatic alcohol having a double bond in an 8-30C carbon chain. The pressure-sensitive adhesive is a copolymer obtained by copolymerizing monomers containing ≥70 wt.% of an alkyl (meth)acrylate in which the carbon number of the alkyl group is 6-20.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To obtain the subject new compound having a methylene chain between functional groups and having ether bond and anionic ester group in long- chain alkyl chain part and having wide application range and excellent in general-purpose properties as a component of liposome, etc., or as drug delivery system agent for chemical modification. SOLUTION: This compound is represented by formula I [R&lt;1&gt; and R&lt;2&gt; are each an alkyl or a group obtained by substituting carbon-carbon single bond of an alkyl with carbon-carbon double bond; R&lt;3&gt; is a lower alkyl or hydrogen; (n) is &gt;=2], e.g. 7,8-dioleyloxy octanoic acid. The compound is obtained by reacting, e.g. a compound of formula II with an alkylating agent such as an alkyl chloride to afford 1,2-dioldialkyl ether, hydroboronizing a terminal carbon of the terminal olefin thereof with a hydroboronizing agent such as diborane and subjecting the reaction product to oxidation reaction with preferably hydrogen peroxide to afford a terminal alcohol of formula III and subjecting the compound of formula III to oxidation reaction with e.g. Jones reagent.
PURPOSE:To obtain a new compound useful as a preventing and a therapeutic agents for hypoxemia due to diseases in respiratory organs. CONSTITUTION:This compound is expressed by formula I [R&lt;1&gt; is H, alkyl, alkenyl or aralkyl ; R&#39;&#39; is alkyl, alkenyl or aralkyl; Y is cyclic amino (G&lt;1&gt; and G&lt;2&gt; are each 1-6C alkyl) such as formula II bound through N to the pyrimidine ring], e.g. 2-allylamino-4-(2,6-dimethylpiperidino)-7-methyl-7H-pyrrlo[2,3- d]pyrimidine. The compound expressed by formula I is obtained by reacting a compound expressed by formula III (X is halogen) with an amine expressed by the formula Y-H under alkaline conditions. The compound expressed by formula I is capable of enhancing the respiratory function in the lungs. Some thereof are capable of raising only the partial pressure of oxygen mainly in arterial blood and some have action on reduction in the partial pressure of gaseous carbon dioxide in the arterial blood together with a rise in the partial pressure of oxygen in the arterial blood.
Cosmetic and/or dermatological composition for treating keratinic fibres comprises a carrier, at least one 2-electron oxidoreductase enzyme, at least one substrate for the enzyme, and at least one anionic amphiphilic polymer derived from at least one hydrophilic monomer and at least one fatty alkyl allyl ether. Preferably the enzyme is an animal, microbial or recombinant uricase and is present in an amount of 0.01-20 (preferably 0.1-5) wt.%. The substrate is selected from uric acid and its salts and is present in an amount of 0.01-20 (preferably 0.1-5) wt.%. The hydrophilic monomer is acrylic acid and/or methacrylic acid. The allyl ether is of formula CH2=CR&#39;CH2OBnR; R&#39; = H or Me; B = CH2CH2O; n = 0-100; and R = 8-30C alkyl, aralkyl, aryl, alkaryl or cycloalkyl, preferably 10-24C alkyl or alkaryl. The allyl ether is especially steareth-10 allyl ether. The polymer is prepared by emulsion polymerisation of 20-60 wt.% (meth)acrylic acid, 5-60 wt.% lower alkyl (meth)acrylate, 2-50 wt.% of the allyl ether and 0-1% of a crosslinking agent. The polymer is a crosslinked copolymer of 40 wt.% methacrylic acid, 50 wt.% ethyl acrylate and 10 wt.% steareth-10 allyl ether. The composition contains 0.05-10 (preferably 0.2-5) wt.% of the polymer. Used for bleaching human hair by applying the composition, optionally containing an auxiliary oxidising agent, and then rinsing; for dyeing human hair by applying a composition as above containing an oxidation dye precursor and optionally a coupler; for permanent waving of human hair by applying a reducing composition, putting the hair under tension, optionally rinsing the hair, applying a composition as above, and optionally rinsing the hair.
PROBLEM TO BE SOLVED: To obtain the subject product capable of determining and/or qualitatively measuring impurity removed on attached surface with one&#39;s own eyes and notifying necessary and enough coating frequency and kind of treatment necessary for the skin to users by providing a colored layer in a patch for removing impurity from skin. SOLUTION: In this patch having a polymer matrix (hereinafter referred to as PM) containing an active ingredient [preferably 5-(n-octanoyl)salicylic acid, etc.], on a supporting supporting layer and having adhesive patch surface which comes in contact with the skin, the patch has a colored layer capable of determining and qualitatively measuring impurity removed by the adhesive surface with one&#39;s own eyes. The colored layer is preferably dark color such as black and preferably formed of PM. Coloring pigment which is not transferred to skin is preferably introduced to PM to color the PM. Zirconium oxide is preferable as the coloring pigment. For example, as a material using polyurethane as a base is exemplified as the PM.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a makeup cosmetic naturally and three-dimensionally improving eyelashes or eyebrows in appearance and pleased by anyone in use on beauty culture.  &lt;P&gt;SOLUTION: This makeup cosmetic is composed by filling fiber powder and a fluid coating material each in different container. The fiber powder is composed of hydrophilic fibers having 10-50 μm cross-sectional dimensions, 200-700 μm fiber length, 5-40 aspect ratio and ≥3% official moisture regain. A nonvolatile ingredient having ≥40°C evaporation temperature is formulated in the fluid coating material and the viscosity thereof is regulated to ≤500,000 poises viscosity thereof. The makeup cosmetic is used by taking out the fluid coating material from the container for the coating material with a brush body, applying the coating material onto the eyelash or eyebrow part, taking out the fiber powder from the container for the powder with a rodlike carrier and applying the fiber powder onto the formed coated film.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
PROBLEM TO BE SOLVED: To provide a solubilizor, an emulsifier and a dispersing agent capable of improving concn. of a matter to be solubilized, a matter to be emulsified and a matter to be dispersed in a water-containing solvent by incorporating the polymer of monomer composition containing a hydrophilic monomer having the group expressed y specified formula at side chain as effective component. SOLUTION: In the solubilizer, emulsifier and dispersing agent the polymer obtained by polymerizing the monomer composition containing the hydrophilic monomer having the group expressed by formula I (wherein, each of R&lt;1&gt; , R&lt;2&gt; and R&lt;3&gt; is hydrogen atom or 1-4C alkyl group and may be the same or different with each other) at the side chain is incorporated as effective component. Then in the hydrophilic monomer, the polymer obtained by polymerizing 100-20wt.% 2-(methacryloyloxy)ethyl-2&#39;-(alkyl substd. or unsubstd. ammonio)ethylphosphate expressed by formula II (wherein, each of R&lt;1&gt; , R&lt;2&gt; and R&lt;3&gt; is hydrogen atom or the 1-4C alkyl group and may be the same or different with each other) and a hydrophobic monomer is incorporated as the effective component.
The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions. The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for use, and their pharmaceutical compositions. A generic means for synchronizing information about a user&#39;s view of a document or other content within an application across native client and web applications is provided. Attendees of an online broadcast are enabled to see what the presenter is seeing within their own application. In addition, meeting-specific information such as the meeting time and notes may be synchronized enabling nearly real time synchronization. Moreover, by enabling attendees to view the presented document within their own applications, the attendees are afforded the capabilities provided by that application, such as navigating through the document manually.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a wiper as one which is impregnated with a chlorine dioxide solution by which the antiseptic effect and disinfecting effect of chlorine dioxide is hardly reduced.  &lt;P&gt;SOLUTION: In the wiper constituted by impregnating the same with the chlorine dioxide solution, the base material of the wiper mainly contains (50% by mass or more of) cellulosic fibers such as of cotton or rayon. Thereby a high chlorine dioxide concentration can be maintained over a long period. Further the deterioration of the wiper itself does not proceed in a certain degree. The wiper can be used for a cleaning and wiping article.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
The present invention discloses an upper limb rehabilitation evaluation system, which includes a rehabilitation sensing unit and a rehabilitation evaluation unit. The stage has a start position and an end position. Each sensing element includes a start sensing piece set at the start position and an end sensing piece set at the end position. The rehabilitation evaluation unit has built-in rehabilitation teaching data displayed on the display module as rehabilitation teaching information. When the subject performs the upper limb movement of picking up the object from the start position to the end position, the start sensing piece and the end sensing piece generate a start signal and an end signal respectively. After the signals are collected and processed, data analysis is performed, and the corresponding electronic evaluation scale information is outputted, so that the rehabilitation movement can be sensed without sticking the sensing element on the limb during the evaluation process. Therefore, it has the following advantages: small size and easy to carry, easy to operate due to the combination of software and the universal design, and that the system can be evaluated and recorded by professional medical staff before the stroke patients can perform operation training by themselves, which greatly improves the patient&#39;s willingness to train independently and accelerates the recovery of the patient&#39;s independence in daily life.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a solid preparation containing ethenzamide that is suppressed in sublimation of ethenzamide.  &lt;P&gt;SOLUTION: The solid preparation includes ethenzamide, polyvinyl alcohol and silicic acid. The solid preparation has an inner layer containing ethenzamide and an outer layer containing polyvinyl alcohol. More preferably, silicic acid is contained at least in the outer layer. As a concrete example of the solid preparation, a film-coated tablet having the outer layer can be mentioned.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To obtain an acrylic acid polymer which is excellent in safety and is useful as a macromolecular emulsifier having good application feeling by copolymerization of (meth)acrylic acid and (meth)acrylic ester at a prescribed ratio. SOLUTION: This polymer contains 50.0-99.0 pts.wt. of at least one kind of monomer of formula I (R&lt;2&gt; is H, methyl; R&lt;2&gt; is a 1-22C alkyl) and 1.0-50 pts.wt. of at least one kind of monomer of formula II. In addition, this polymer contains a cross-linking agent in an amount of 0.001-10.0 pts.wt. When this polymer is measured the FT-IR by KBr method, the absorption attributed to carboxylic acid and the absorption attributed to carboxylic ester are shown. This polymer is soluble in any oil including silicone, nonpolymer and polar oils and insoluble in water. This polymer can be emulsified to form the oil-in-water type emulsion which is kept stable at 50 deg.C for 1 month. Thus, this emulsion can be used over a wide range of fields including cosmetics and medicines.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a cleansing agent that can simply and easily ameliorate in a short period, skin darkening, discoloration of the skin caused by cosmetics and skin blackening caused by sunburning, all of which cannot be removed with cleansing soap, a packing agent and a keratin removing agent.  &lt;P&gt;SOLUTION: This cleansing agent comprises a resin emulsion that has a particle size of ≤ 0.10 μm and a film-forming temperature of 0°C to 10°C and comprises one or two or more kinds of resin-curing accelerators and one or two or more kinds of resin-curing retarders. The resin-curing accelerators are needed by 1 to 10 % of the resin weight, while the resin-curing retarders are needed by 2 to 20 % of the resin weight. The retarders increase the cleansing effect when used in combination with a polyhydric alcohol. The cleansing agent is applied to a body part that is wanted to be cleansed once a day and the formed resin film is peeled off at 4 to 5 minutes after application whereby the dirty on the skin is removed together with the resin film peeled. The daily application is repeated for 4-5 days to remarkably clean the dirty skin.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
FIELD: virology. SUBSTANCE: strain of Newcastle virus disease &#34;M-VNIIVViM&#34; is obtained from epizootic virus isolated from broiler chickens in poultry plant in town Murmansk by selection for trait of maximal accumulation in transplantable cellular culture VNK-21/13. Strain obtained on the level of 6-15 passages can be used as living cultural vaccine for poultry immunization against Newcastle disease in poultry plants. Vaccine is safety and shows areactogenic and immunogenic properties based on checking experimental series of vaccine. A single vaccination of poultry provides 75-100% protection from control infection with epizootic Newcastle disease virus in the dose 3000-5000 ELD 50 /head. EFFECT: valuable properties of vaccine. 1 tbl
&lt;P&gt;PROBLEM TO BE SOLVED: To simply emulsify or solubilize a slightly water-soluble physiologically active substance in water with good dispersion stability and to improve the touch or/and stability of a physiologically active substance in water when used for a cosmetic or an external preparation for skin depending on the kind of the slightly water-soluble physiologically active substance.  &lt;P&gt;SOLUTION: A slightly water-soluble physiologically active substance-phospholipid composite, obtained by removing an organic solvent from a solution in which the slightly water-soluble physiologically active substance and a phospholipid are uniformly dissolved in the organic solvent and simultaneously depositing the slightly water-soluble physiologically active substance and phospholipid, is used. Furthermore, a slightly water-soluble physiologically active substance-sterol-phospholipid composite comprising the sterol is used. The slightly water-soluble physiologically active substance can simply be emulsified or solubilized in water by using the composite. The resultant emulsified or solubilized composition has high dispersion stability. The touch when used in the cosmetic or external preparation for skin or/and stability of the physiologically active substance in water are improved depending on the kind of the physiologically active substance.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a drug dissolving device in a tubular organ to be applied to occlusion or reocclution of the tubular organ such as a blood vessel irrelevant to an acute or chronic case.  &lt;P&gt;SOLUTION: This device is inserted into the tubular organ and prevents restenosis of the tubular organ. This device carries the drug is dissolved after positioned in the tubular organ and preventing the restenosis. This device, at least, includes a single type of drug, and the drug is fed to a necessary point at a controlled rate without excessively fed due to the systemic dosing. This device comprises a flexible tubular body and the body is fixed to the wall of the tubular organ by a mechanical operation.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
A foil for use in hair coloring is made of a substantially rectangular sheet of material. The upper edge of the foil is pinked, forming a zig-zag pattern. The upper surface of the foil contains a hair restraint in proximity to the foil&#39;s upper edge, formed of an elongated, rectangular strip of loop material which adheres to the hair. The lower surface of the foil contains a similar elongated rectangular strip of loop material, providing an attachment anchor, which adheres to the scalp of the subject without the stylist having to hold the foil during the entire coloring process. After the foil has been attached to the subject&#39;s hair in proximity to a part, hair strands are woven from under the foil, over the upper edge, and held in place by the hair restraint. Coloring is then applied, and the foil folded in half, retaining the hair within the folded foil.
A medical device, kit and method for conducting papanicolaou (pap) test is disclosed.  The device comprises a protective guide, an endoscopic device, a cell extraction device, and a computing device. The protective guide has an upper chamber and a lower chamber. The endoscope has a camera and a light emitting device assembly. The endoscope is securely positioned within the upper chamber. The cell extraction device has a handle at one end and a brush affixed at another end. The cell extraction device is slidably positioned within the lower chamber. The cell extraction device is configured to slide outward for positioning the brush around the user&#39;s cervix, thereby conveniently allowing for a cervical cell sample to be collected. The computing device in communication with the endoscope device and is configured to improve detection accuracy and visual examinations of the targeted cervical area, thereby enabling the user to collect the cervical cell sample for conducting the PAP test.
PROBLEM TO BE SOLVED: To obtain the subject composition with favorable deposition onto the trachea by including spherically formed medicinal fine particles coated with a biodegradable and bioadhesive polymer so as to extend the intratracheal persistence of the medicinal fine particles and sustain its efficacy. SOLUTION: This powdery medicinal composition is obtained by coating the surface of medicinal fine particles with a biodegradable and bioadhesive polymer (e.g. hyaluronate, chondroitin sulfate); wherein the weight ratio of the polymer to medicinal fine particles is pref. (2:98) to (10:90), and the medicinal fine particles is formed, e.g. by spray-drying process, to such a sphericity as to be &gt;=0.90 as a result of particle evaluation based on Wadell sphericity ψs, having a size of pref. 0.5-10 μm [wherein, the medicinal being highly lipophilic one, such as adrenal cortical hormone (e.g. beclometasone propionate), sex hormone (e.g. testosterone), activated vitamin D3 , prostaglandin].
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a medicinal composition effective for treating mood disorders.  &lt;P&gt;SOLUTION: This medicinal composition contains a carbostyril derivative and a serotonin reuptake inhibitor. The carbostyril derivative contains aripiprasol and its metabolic products. The serotonin reuptake inhibitor contains fluoxetine, duloxetine, venlafaxine, milnacipran, citaloplam, fluvoxamine, paroxetine, sertraline and escitalopram. The mood disorders such as depression are effectively treated by using the carbostyril derivative together with the serotonine re-uptake inhibitor.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI