anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain an external preparation for skins which shows an excellent stability and safety, is highly effective in moisturizing skins, producing beautiful skins and alleviating rough skin problems and fits comfortably to skins, by sufficiently improving physiological functions of the skins.  &lt;P&gt;SOLUTION: The external preparation for skins is allowed to contain an extract mixture comprising extracts from Matricaria chamomilla L., Foeniculum vulgare Miller, Humulus lupulus L., Achillea millefolium L., Melissa officinalis L. and Viscum coloratum Nakai var. lutescens Miyabe et Kudo or Viscum album L. var. lutescens Makino, extracts from Foeniculum vulgare Miller, Aesculus turbinata Blume and/or Aesculus hippocastanum L. and Daucus carota L., extracts from Matricaria chamomilla L., Achillea millefolium L., at least one Hypericum spp., Tussilago farfara L., Althaea officinalis L. and Salvia officinalis L. and/or its variant, or extracts from Salvia officinalis L. and/or its variant, Hamamelis virginiana L., Thymus vulgaris L., Potentilla tormentilla and Rosmarinus officinalis L., in combination with at least one extract chosen from a group consisting of extracts of specific plant species. At least two preparations chosen from these are used for treating skins.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a material produced from clay of the marl (sea silt, Kucha) which is distributed in the southern part of the Okinawa main island, not only by utilizing such a property of the clay that the clay comprises very fine mineral particles and has a cleaning effect in which the clay particles adhere to the dirt components of the skin and the dirt of the teeth through the strong adsorptivity thereof and make the dirt components and the dirt able to be easily washed away by water rinsing, but also by making use of such a property of the clay that the clay naturally has a relatively strong electric charge possessed by the above mineral fine particles; and production method thereof.  &lt;P&gt;SOLUTION: Among the above clay mineral particles, particles which are charged more clearly are accelerated to settle down by electrophoresis for agglomerating the particles and accelerating the precipitation of the particles by an electrophoresis device. Further, as a result of the electrophoresis, reduction of water can be accelerated. By a method in which a product, such as a poultice is produced by incorporating a few % of an electrolyte into the composition of the product, a new type of an analgesic poultice in which the analgesic effect is more strengthened by enhancing the ion-exchanging properties and the electric conductivity of the poultice can be developed. By utilizing the absorptivity of the mineral particles, not only the cosmetics for the skin pack of the face or the like, a cleansing gel for the skin and a shampoo for the hair, but also a toothpaste and a cleanser for the kitchen can be produced. Since by applying an electric current to the clay particles suspension using an electrophoresis device, the suspension is strongly reduced, the production of a reduced water utilizing this reduction reaction can be performed.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a recombinant human interleukin-3 (hIL-3) variant or mutant protein (mutein).  &lt;P&gt;SOLUTION: The hIL-3 mutein contains amino acid substitutions and may also have amino acid deletions at both the N- and the C-termini. A pharmaceutical composition comprises the hIL-3 mutein. A method for using the same is provided. Furthermore, a recombinant expression vector comprising a nucleotide sequence encoding the hIL-3 mutein, a related microbial expression system and a method for producing the hIL-3 mutein using the microbial expression system are provided. Deleted muteins of the hIL-3 in which 1-14 amino acids are deleted from the N-terminus, 1-15 amino acids (119-133) are deleted from the C-terminus, and in which the amino acid substitutions are contained in the polypeptide are provided. The hIL-3 multiple mutation polypeptide may have a biological activity similar to or better than that of the hIL-3 and may have an improved adverse effect profile.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a solid powdery cosmetic effectively suppressing the oozing and spreading of a volatile solvent absorbed in an absorption sheet and having good appearance.  &lt;P&gt;SOLUTION: The interior of a housing pan 1 is initially filled with a fluid filler 2 prepared by dissolving a cosmetic base with a volatile solvent and the absorption sheet 5 for absorbing the volatile solvent oozed out of the filler 2 is interposed between the housing pan 1 and a pressing plate 4. Furthermore, the pressing plate 4 in such a state that the absorption sheet 5 is interposed therebetween is pushed down. Thereby, the filler 2 filled in the housing pan 1 is compression molded. An absorption sheet having ≥400 to ≤1,600 g/m&lt;SP&gt;2&lt;/SP&gt;absorption rate of the volatile solvent per unit area is used as the absorption sheet 5.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
The invention provides a novel vehicle for vaccination, in particular peptide vaccination. The new vehicle has been termed an exosome. Exosomes are vesicles derived from MHC class II enriched compartments in antigen presenting cells.  The exosomes possess MHC II and/or MHC I molecules at their surface and possibly peptides derived from processed antigens in said MHC&#39;s. Thus the exosome is a perfect vaccination vehicle in that it presents the peptide in a natural setting. The peptides present in the exosome in the MHC molecule may be processed by the antigen presenting cell from which the exosome is derived.  Empty MHC molecules on exosomes may also be loaded with peptides afterwards.
The invention belongs to the technical field of traditional Chinese medicine preparation, and discloses a pharmaceutical composition for preventing and treating stomach diseases and a preparation method thereof, wherein the pharmaceutical composition for preventing and treating stomach diseases comprises 1-2 parts by weight of pericarpium citri reticulatae and 1-2 parts by weight of fried chicken&#39;s gizzard-membrane. The invention regulates qi, strengthens spleen, stimulates appetite, and neutralizes accumulation; can be used for treating qi stagnation of spleen and stomach, abdominal distention, anorexia, etc. The invention adopts two medicinal and edible varieties of pericarpium citri reticulatae and endothelium corneum gigeriae galli, has reliable safety and no toxic or side effect or adverse reaction, is suitable for the old and the young, and is a good medicine for treating stomach diseases. Meanwhile, the medicine source is wide, the process is simple, and the price is lower than that of other treatment medicines. Is expected to provide a safe and reliable pure Chinese medicinal preparation for treating gastropathy. The invention has unique prescription, can directly attack the focus and expel pathogenic factors, and has low recurrence rate and lasting curative effect. The invention is proved by clinical verification to be safe and effective to take and has obvious curative effect on treating the gastropathy.
The present invention relates to a one-course three-plaster plaster for treating cure. The plaster is composed of a No. 1 plaster, a No. 2 plaster and a No. 3 plaster, wherein the No. 1 plaster contains huechys, realgar, mylabris and calomel and is compounded into paste by adding honey with the right amount; the raw materials of the No. 2 plaster contain raw arisaema, calcined gypsum powder, borneol, menthol, qingdai and gamboge, and medical powder is stirred evenly into paste with the mixture of vaseline and honey respectively with quality of a half; the No. 3 plaster contains tuber of hyacinth bletilla, dahurian angelica, dragon&#39;s blood, frankincense, myrrh, flos caryophyllata, cinnabar and musk, and the medical powder is prepared into paste with the mixture of vaseline and honey respectively with the quality of a half. In treatment, one course of treatment is divided into three times with different plasters. The present invention has good therapeutic effect on, cervical spondylosis, local pain of body surface tissues caused by wind, cold, moisture, factor, fatigue and injury and radioactive pain caused by intervertebral disk hernia, hyperostosis stimulation and oppressive nerve root.
Through a physician&#39;s portal, a platform calculates efficacy ratings for patient records matching a medical condition and generates reports. The physician uses the reports to create a cannabis treatment prescription for the patient, which is stored in the patient&#39;s record. An electronic notification message is sent to the patient with a unique access code, which the patient may use to retrieve the cannabis treatment prescription via a patient&#39;s portal. After the patient obtains cannabis products, the patient inputs cannabis treatment data via the patient&#39;s portal, including cannabis profile of the cannabis products and a patient efficacy rating, which are stored in the patient&#39;s record. The physician retrieves the cannabis treatment data via the physician&#39;s portal and optionally modifies the prescription. The patient retrieves the modified prescription via the patient&#39;s portal. In this manner, networking communication channels between physician and patient for cannabis treatment and result data are provided.
&lt;P&gt;PROBLEM TO BE SOLVED: To automatically collect scheduled medical acts and give a warning when an error occurs.  &lt;P&gt;SOLUTION: The scheduled medical acts inputted by a portable information input device 100 are collated with information held by a medical plan information management system 200. When there is any discrepancy, the warning is given and the discrepancy is stored as part of medical record log information 10. A system for collecting medical accident prevention information 300 extracts record information of medical accident prevention from the medical record log information 10, transmits the record information to a medical accident prevention information recorder 500 as medical accident prevention record information 20 and the medical accident prevention information recorder 500 processes the record information of medical accident prevention by making it into a format common to other reports inputted from a medical accident information entry system 400 and stores the resultant record information in a medical accident prevention information DB 600. A medical information analyzing apparatus 700 properly reads the medical accident prevention record information 20 and analyzes the tendency of the occurrence of medical accidents, etc.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
PURPOSE:To provide an easily producible water-based bile acid agent for internal use, which is an easily drinkable clear liquid having masked intrinsic bitter taste of bile acid and useful as a cholagogue, by compounding a specific amount of dextrin to bile acid. CONSTITUTION:The objective water-based bile acid agent for internal use can be produced by compounding a dextrin (e.g. amylodextrin, erythrodextrin, etc.) to a bile acid (e.g. ursodeoxycholic acid, chenodeoxycholic acid, etc.). The weight ratio of dextrin to bile acid is &gt;= 30 and the concentration of dextrin in the agent is &lt;= 35% (W/W). It can be prepared either by fluidized layer granulation method or dispersion method. The hazard of bile acid scattering is suppressed compared with the conventional process for preparation of a water-based agent using a bile acid cllathrate compound. A clear agent free from bitter taste can be produced with simple procedure. The nature of dextrin is weakly acidic and, accordingly, the requirement of a water-based internal agent can be satisfied without pH adjustment.
1/ Dietetic applications A release of the micronutrients at the appropriate point in the digestive tract is brought about by the technique of coacervation in gelatin followed by crosslinking. This results in:     - increased tolerance,   - lack of competition between micronutrients,   - protection of the micronutrients against gastric acidity,   - intact bioavailability,   - sequential absorption of the micronutrients.   2/ Pharmaceutical applications The invention enables therapeutic active principles previously chelated around a metal to be protected, transported and released at will. When performed in the absence of oxygen, the method makes it possible to bring about a better balance of the intestinal flora using strict anaerobic ferments. It permits the simultaneous administration of water-soluble and fat-soluble medicaments. Depending on the degree of crosslinking of the gelatin and the nature of the coatings carried out, the invention enables the release of the active principles to be staggered over time. This is the meaning of the term &#34;differential timed release&#34;.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an isolated monoclonal antibody with high affinity which specifically binds with a Programmed Death 1 (PD-1), particularly a human monoclonal antibody.  &lt;P&gt;SOLUTION: An isolated human monoclonal antibody cross competitively binds with a reference antibody including human heavy- and light-chain variable areas composed of specific amino acid sequences and PD-1 or its binding site. An immunocomplex containing an antibody, a double specific molecule and a pharmaceutical composition are prepared to make possible a PD-1 detection method and curable various diseases including cancer and infectious diseases. Furthermore, highly proliferative diseases such as cancer can also be treated by a concurrent immunotherapy such as a combination of anti-CTLA-4 and anti-PD-1 antibodies. Harmful phenomena related to each therapy of such antibodies are modified.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
A method provides statistically reliable life experiences to guide a user to achieve personal goals related to education, career, and other life choice options. Based on the user&#39;s specific query, the method conducts searches and analyzes the search results for statistical significance. Internal anonymized databases containing life experiences and extensive external databases are used in the search and analysis. Subsequently the method sends the most relevant life experiences to the user with optional link to specific providers related with the query to the user for achieving the user&#39;s personal goals. The method may notify the user for lack of records/data and creates a survey to all users to contribute answers and/or life experiences to the specific query. Further, the method allows service providers and law enforcement personnel to conduct queries with specific purposes such as medical survey or criminal investigation with a subpoena.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for sythesizing and using oligomeric compounds including oligoribonucleotides and oligoribonucleosides, useful for cleaving strand of target RNA.  &lt;P&gt;SOLUTION: Oligomeric compounds including oligoribonucleotides and oligoribonucleosides are provided that have subsequences of 2&#39;-pentoribofuranosyl nucleosides that activate dsRNase. Also provided are mammalian ribonucleases, i.e., enzymes that degrade RNA, and substrates for such ribonucleases. Such ribonuclease is referred to herein as a dsRNase. The oligoribonucleotides and oligoribonucleosides can include substituent groups for increasing binding affinity to complementary nucleic acid strand as well as substituent groups for increasing nuclease resistance. The oligomeric compounds are useful for diagnostics and other research purposes, for modulating the expression of a protein in organisms, and for the diagnosis, detection and treatment of other conditions susceptible to oligonucleotide therapeutics.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
The invention relates to a GDNF gene-polycation nano-particle composition, a preparation method and an application thereof. The nano-particle composition comprises a GDNF gene substance and polycation. The polycation is polyspermineimidazole-4,5-diimine or polyspermineimidazole-4,5-diamide. A mass ratio of the polycation to the GDNF gene substance is 5-100. The nano-particle composition is less in toxin, is high in transfection efficiency, can achieve both stability before arriving a target cell and a biologically-responsibility after entering the target cell during an in-vivo circulation process. Polycation itself can be metabolized toxic-free in-vivo so that the nano-particle composition can be used for treating Parkinson&#39;s disease and complications thereof through intracranially local injection.
PROBLEM TO BE SOLVED: To obtain an enteric nutritional supplementary composition effective in treatment and prevention of inflammatory diseases of the gastrointestinal duct, e.g. Crohn&#39;s disease. SOLUTION: This composition comprises (a) casein rich in TGF-β2, (b) a lipid source which supplies approximately 35 to 50% of energy, and (c) a carbohydrate source. One of the preferred embodiments of the composition is as follows: the casein contains 1.2 to 2.0μg/g of TGF-β2, or 10 to 40μg of TGF-β2 is present in 100g of the composition. The lipid source is composed of a mixture of 20wt.% or less of medium-chain triglyceride and long-chain triglyceride, and contains polyunsaturated essential fatty acids which supply 10% or less of the lipid energy. The composition has an energy content in a range from 800 to 1200kcal/l, of which 10 to 14.5% is supplied by the casein.
The present invention provides compositions and methods designed to increase value output of a fermentation reaction that yields a first product, intended for commercialization, such as ethanol, and a fermentation residual used, for example, as animal feed. The methods involve using microorganisms in the fermentation process that have been modified so as to yield a residual having greater value that a residual produced in the process by a microorganism not so modified. In particular, the present invention contemplates using microorganisms in a fermentation process that have been modified to increase production of a nutrient, such as an essential amino acid, thereby reducing the need to supplement the nutrient in the animal&#39;s diet. The present invention also provides a modified fermentation residual of higher commercial value. Also provided in the present invention are complete animal feeds, nutritional supplements comprising the subject ferment residuals. Further provided by the present invention is a method of performing fermentation, a modified fermentative microorganism and a genetic vehicle for modifying such microorganism.
A method is provided which facilitates diagnosis of any describable condition or event. One example is specialty related medical conditions and diseases. The method first provides, in a computer accessible data base, for the creation of a plurality of master maps using keywords and a new diagnostic mapping language. Then a medical description of a patient&#39;s history and physical information is input into a computer using simple medical file language. Chemical and test data information are displayed on the screen to prompt entry of available chemical and test data for the patient, and this may also be practiced for imaging selections which may be in a yes/no/empty format. Using a computer processor a data base of specialty medical information is searched to determine the degree of similarity between the information entered and the master maps, and the possible diagnoses are ranked based on the degree of similarity. The three most probable diagnoses are displayed on a monitor, such as in the form of horizontal bar graphics which bar graph is a first color in a horizontal field and the diagnosis corresponding to the bar graph is in the same field in a different color. Biopsy and imaging icons, which are miniature versions of actual biopsies or images exemplary of the disease or condition, may be selected. The computer and data base may be used in a catalog mode, in addition to the above-description analytical mode, by displaying on the screen options relating to the biopsy, imaging, management (a condensed opinion and textual information about how to understand and treat a particular disease or medical condition) and bibliography (a listing of suggested readings).
PURPOSE:To obtain a bathing agent composition having excellent skin care effect, by adding a component composed of an eggshell membrane to a bathing agent for foaming a carbon dioxide gas and controlling constant pH of bathing water in a bathtub. CONSTITUTION:A bathing agent for foaming a carbon dioxide gas, consisting essentially of a carbonate (e.g. sodium carbonate) and an organic acid (e.g. malic acid) is mixed with a membrane component existing inside of eggshell of a bird such as chicken, quail or duck. The concentration of the membrane component is 0.001-1,000ppm calculated as the membrane component (0.2mg-200g in 200l bathing water). The bathing agent is adjusted to have pH&gt;=6, preferably pH6-10 when dissolved in water in a bathtub, and prepared into tablets, powder or granule. The bathing agent has high skin care effect and is inexpensively obtained by adding an eggshell membrane component and controlling bathing water at pH&gt;=6.
Disclosed methodologies provide improved predictors of patient treatment adherence by using person-specific subjective experience and social-environmental factors. Methodologies combine emotion and data sciences. Advanced tools capture, measure, store, and analyze self-report of subjective experiences using digital applications and platforms. Patient-specific data is obtained regarding emotional or affective determinants and social determinants for generating a calculated composite score of the patient&#39;s probability of adherence or achievement relative to target outcomes, e.g. adherence to treatment plans, wellness activities, etc. for a subject individual. Internal/subjective factors are judged by self-report measures designed to validly judge tested factors based on a patient adjusting continuously-variable graphical interfaces to capture and measure subjective experiences. Emotional characteristics may include perception and intensity in each category of sickness versus wellness, stress, depression, anxiety, pain, and feelings about most recent health provider/staff interaction (with determined intensity for choices of Delighted, Satisfied, Meh, Disappointed, Frustrated). Emotional characteristics may be considered among health, and social characteristics in measuring potential obstacles to adherence.
PROBLEM TO BE SOLVED: To assist a medical doctor who has long used paper charts in preparing an electronic clinical chart in short time.SOLUTION: An electronic clinical chart preparation apparatus according to an embodiment is an apparatus for preparing an electronic clinical chart on which patient information is recorded. Voice analysis means analyzes voice and converts the voice to character information. Medical word storage means stores a plurality of medical words. Extraction means extracts entry character candidates from the character information obtained by the voice analysis means on the basis of the medical words stored in the medical word storage means. First presenting means displays the character information obtained by the voice analysis means, and also presents the entry character candidates included in the character information in a selectable manner. First recording processing means enters input character candidates selected by a user&#39;s operation to a plurality of entry items included in an electronic clinical chart.