anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
Compositions and methods for making cDNA from RNA templates, including double-stranded RNA (dsRNA) and single-stranded RNA (ssRNA), are provided. The composition and methods include a recombinant or purified or modified or recombinant RNA dependent RNA polymerases (RdRp&#39;s). The RdRp has an amino acid sequence that shares identity to a contiguous segment of the amino acid sequence of one or more Partitiviridae virus RdRps, and includes a reverse transcriptase (RT) domain. Kits including dNTPs for use in generating cDNAs are included. The RdRps can function efficiently at lower temperatures than previously available RT enzymes. Methods of making cDNAs are provided using an RdRp are also provided. RdRps can also be used to identify candidate reverse transcriptase inhibitors.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a skin care preparation having excellent effects for preventing and ameliorating rough skin.  &lt;P&gt;SOLUTION: This skin care preparation contains a metal-doped barium sulfate powder obtained by reacting a barium ion with a sulfate ion in the coexistence of a metal ion. Preferably, the molar ratio of the barium ion, the sulfate ion and the metal ion is 1:(0.5-2):(0.001-10). Preferably, the metal ion is one or more kinds selected from the group consisting of lithium ion, sodium ion and zinc ion. The content of the metal-doped barium sulfate powder based on the amount of the skin care preparation is preferably 3-40 wt.%.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
NEW MATERIAL:A compound SA3097 expressed by formula I (R&lt;1&gt; is H or lower alkyl; R&lt;2&gt; is lower alkyl) and pharmaceutically acceptable salts thereof. EXAMPLE:A compound expressed by formula II. USE:A carcinostatic agent. PREPARATION:A microorganism, e.g. Streptomyces.sp. SA-3097 strain (FERM P-11481), belonging to the genus Streptomyces and having the ability to produce the compound SA3097 expressed by formula I is cultured and the compound expressed by formula I is then collected from the resultant culture thereof according to a well-known method.
PROBLEM TO BE SOLVED: To obtain a hair cosmetic slight in lowering in setting power/setting durability caused by plasticity of an oil component and a little in reduction in smoothness resulting from a polymer resin compound, by combining an oil-in- water type emulsion with the polymer resin compound. SOLUTION: A hydrophilic nonionic surfactant to which &gt;=15mol ethylene oxide is subjected to addition polymerization, for example, is dissolved in a water-soluble solvent. Thereafter, an oil phase is added to the solution, the hydrophilic nonionic surfactant is efficiently orientated in the interface by taking advantage of weak surface tension and water is gradually added to the resulting solution to give an oil-in-water type emulsion. A polymer resin compound dissolved in water or a lower alcohol is added to the emulsion. An ampholytic polymer resin compound, a cationic polymer resin compound or a nonionic polymer resin compound is preferable as the polymer resin compound. The amount of the compound blended is preferably 0.1-10wt.%, especially about 1.0-5.0wt.%. The hair cosmetic is usable as an aerosol type hair cosmetic by using a liquefied gas propellant.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a sustained release pharmaceutical preparation specifically deliverable to the large intestine and sustainedly releasing an effective amount of a medicinally effective ingredient.  &lt;P&gt;SOLUTION: The sustained release pharmaceutical preparation comprises a high-temperature swelling gel-like polymer (A) and a drug (b) absorbed for acting in the large intestine. The gel-like polymer is preferably swelled at a temperature in the large intestine. The surfaces of the gel-like polymer (A) and the therapeutic agent (b) for the diseases in the large intestine are preferably coated with an enteric film. The gel-like polymer (A) is preferably a polymer composite having an interpenetrating network structure of a cross-linkable polymer containing (a-1) an acrylamide or a methacrylamide unit (i) and an N-alkyl-substituted (meth)acrylamide unit (ii) as essential constituent units with (a-2) a cross-linkable polymer containing (a-2) an acrylic or a methacrylic acid unit (i) and the N-alkyl-substituted (meth)acrylamide unit (ii) as essential constituent units.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
The present disclosure is directed towards systems and methods built for predictively timing the inflation and/or deflation of an intra-aortic balloon pump. A controller operates in three states: (1) initialization state, (2) learning state, and (3) peak detection state. The controller decomposes a patient&#39;s electrocardiogram signal to a power signal. It then learns characteristics of the patient&#39;s electrocardiogram signal during the learning state and computes adaptive threshold parameter values. During the peak detection state, the controller applies the learnt threshold parameter values on a current electrocardiogram signal to identify occurrence and timings of R peaks in the electrocardiogram signal. The R-to-R peak timings are then used to trigger inflation of an intra-aortic balloon pump.
PURPOSE:An ointment base for the skin, prepared by adding a very small  amount of a perfume to incrustations of hot-spring water naturally occurring in  large amounts and an extract of a plant of the genus aloe, capable of cleaning  the surface of the skin in a short time, showing the skin beautifying effects, and preparable at a low cost without side effects. CONSTITUTION:An ointment base prepared by adding a very small amount of a perfume to a kneaded mixture of incrustations of hot-spring water with an extract from a plant of the genus Aloe. The resultant mixture prepared by kneading the incrustations of hot-spring water with the extract from a plant of the genus Aloe and vaseline is rubbed fully into an affected part of athlete&#39;s foot, insect bites, chilblain, cuts, hemorrhoids, etc. to alleviate the pain or itching. The surface of the skin is smoothed, and the skin beautifying effect can be produced by repeating the pack of the base diluted with a solvent, e.g. vaseline, on the roughened part of the skin, e.g. a pimple. EFFECT:The pharmacological effect of the hot spring is obtained at a low cost though indirectly.
PURPOSE: To obtain through rapid polymerization the subject composition excellent in aethetics, mechanical strength, wear resistance, water resistance and curability by using in a dental composite resin a specific sulfur-contg. monomer presenting the refractive index at a specified level or higher when polymerized. CONSTITUTION: This dental material contains a sulfur-contg. monomer presenting the refractive index at &gt;=1.56 when polymerized. The other objective resin composition is obtained by polymerizing this dental material. The sulfur-contg. monomer is pref. a (meth)acrylic ester of formula I (A is 0 or S; R1 is H or methyl; R2 and R5 are each an alkylene or cycloalkylene; R3 and R4 are each the same as R2 or R5 , phenyl or naphthalene; n and n&#39; are each 0-3) or formula II. When the sulfur-contg. monomer is used in a dental composite resin, the resin is rapidly polymerized, and there is no turbidity in the resultant polymer at all even if any X-ray contrast medium is contained in the resin.
BACKGROUND AND PURPOSE: <p>Body mass index (BMI) is positively correlated with the frequency of carpal tunnel syndrome (CTS). However, there are different types of obesity, and the localization of adipose tissue differs between the genders. In this study, we purposed to investigate whether there was an association between the amount of local adipose tissue thickness and anthropometry in upper extremity with the presence and/or electrophysiological severity of CTS on both genders.</p>.
METHODS: <p>Our study included 150 patients who were diagnosed with CTS clinically and electrophysiologically and 165 healthy controls. The biceps and triceps skinfold thickness, the diameters of the wrist and metacarpal joints, and the upper arm circumferences over the belly of the biceps muscle were measured by using skinfold caliper and measuring cylinder. All data were analyzed by using the Statistics Open For All package (SofaStats) programme. To detect the role of anthropometric indexes, we used multivariable multinomial logistic regression models.&nbsp;</p>.
RESULTS: <p>We revealed that BMI, biceps and triceps adipose tissue thicknesses were higher in females and also in patients with CTS. There was a positive correlation between electrophysiological grades of CTS and BMI with logistic regression analyzes. The mean Wrist circumference/Metacarpo&shy;ph&shy;arengeal Circumference ratio and biceps circumference were higher in moderate CTS groups. Metacarpofarengeal circumference was smaller in mild and moderate CTS cases compared to healthy ones.</p>.
CONCLUSION: <p>We suggest that the differen&shy;ces between the anatomical bone structure and local adiposity between the genders may play an important role in the occurrence of CTS. Moreover, the structures of proximal muscle groups and distal metacarpal joints may contribute both to the development and severity of CTS.</p>.
Compsns. for treating multiple sclerosis, lateral sclerosis, disorders of the peripheral nervous system and diseases other than tooth inflammations and ostitis of the jaw, e.g. epilepsy, blood clotting disorders and hair loss, comprise finely divided teeth (with nerves removed) and/or jaw bone fragments (attacked by ostitis) taken from one or more patients with the same sort of illness as that to be treated. - The teeth (esp. wisdom teeth) and/or jaw bone fragments are finely ground, sterilised, and diluted by the Korsakow method, in which the ground material is placed in a beaker, a liq. (e.g. water) is added, the beaker is &#39;dynamised&#39;, the beaker is emptied, and the prod. remaining on the walls of the beaker is diluted with fresh liq., this being repeated 30 times. The prod. may be formulated as drops, tablets or pills.
A user inputs information identifying a person and the user. A computer system analyzes the user&#39;s voice to verify or determine the user&#39;s identity, and allows only valid users to access the system. The input information is compared to benefits information stored in the system to make automatic determinations concerning the benefits, and those determinations are transmitted to the user. The user is prompted to provide information in a format specified by the user and receives information in a format specified by the user. Other users, such as benefit organizations, also receive information in a format that they specify. When automatic authorization (or communication) by a facilitator computer is not appropriate, information is transmitted to a benefit organization computer, and further computer analysis or manual analysis is performed, and determinations concerning benefits are transmitted to the user. In a preferred embodiment, the user inputs diagnosis codes and action codes, and either a facilitator computer or a benefits organization computer or a benefits organization operator makes the determination that is sent to the user.
The present invention relates to a traditional Chinese medicine preparation for quickly setting a broken bone, particularly to a traditional Chinese medicine preparation for quickly setting a broken bone, which is prepared by Chinese herbal medicines and belongs to the technical field of traditional Chinese medicines. The preparation is mainly composed of muskiness, angelica, saffron, dragon&#39;s blood, panax pseudo-ginseng, hemlock parsley, notopterygium roots, dipsacus roots, natural copper, psoralea, frankincense, myrrh, dragon bones, earthworms, soil insects, rehmanniae roots, prepared rehmanniae roots, epimedium herb, caesalpinia sappan and corresponding channel medicines. The present invention selects different corresponding channel medicines according to different fracture parts, and leads channels of affected parts and enhances the permeability of capillaries by the corresponding channel medicines. The medicine suppresses the infiltration and exudation of partial inflammation, resists concretion and thrombus, and quickens the restoration of damaged tissues and fracture concrescence. The present invention has the efficacy of activating blood circulation to dissipate blood stasis, relieving inflammation, eliminating tumefaction, alleviating pains and setting a broken bone and veins. Patients can walk after taking the medicine for 3 to 4 weeks. Because the guiding medicine of the present invention enters channels, the present invention has the advantages of short therapeutic course, high therapeutic effect, quick bone junction, safety, no toxic and side effect and low medicine cost.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a release sheet (a liner) for a plaster, capable of raising operability in applying a sticking plaster so that the plaster is made easy to put, and a user can apply the plaster by him/herself, especially, to the rear surface (a back side surface) of his/her body without sticking adhesive surfaces.  &lt;P&gt;SOLUTION: The liner with a double structure by folding is used for the release sheet. The contact surface of the doubled liner and the liner is kept being stuck, but, can be easily released as necessary. When an operation is performed by picking the distal end of the released and developed liner, the liner is stuck onto a body surface to which a hand does not easily reach. The liner with the double structure is also used so as to cover a part of or the whole of the plaster (a conventional single liner can be used for the remaining part). As an example for the usage, there is such a form that the folding part of the respective liner parts in the double structure is brought into contact with a part at the longitudinal center of support bodies (a non-woven fabric and a base fabric).  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
A technique for predicting bone resection issues during robotic surgery is provided. The technique includes accessing robotic surgery resection parameters and receiving landmarks from the distal end of a patient&#39;s femur. A 3D model of the distal femur is generated based on the landmarks. A virtual robotic resection of the distal femur is simulated using the model and parameters. Analysis of the simulated resection predicts possible issues like notching of the trochlea. Warnings are generated if problems are predicted, allowing the surgeon to adjust the plan pre-operatively. By simulating the robotic bone resection, potential problems can be anticipated and avoided through appropriate changes to the surgical plan.
PROBLEM TO BE SOLVED: To obtain a transparent emulsion of an oil-in-water type giving skin moisture, useful in treating oily skin and sensitive skin by adding a specific surfactant to an oil-in-water dispersion system. SOLUTION: A silicone surfactant is admixed to an oil-in-water dispersion system including oil particles with an average size of &lt;100nm. The silicone surfactant is particularly a compound of formula I (R1 to R3 are each an alkyl; R4 is H, an alkyl; A is 0-200; B is 0-50), formula II (A is 20-105; B is 2-10; y is 10-20) and formula III (A&#39; and y are each 10-20). The amount of the silicone surfactant is 1-15wt.%, particularly 3-6wt.% based on the total weight of the emulsion. The oil phase is 5-40wt.%, particularly 10-30wt.% based on the whole weight of the emulsion. Moreover, an ionic and amphiphatic lipid may be added.
Embodiments of the disclosure provide compositions, kits, and methods for allogeneic hematopoietic cell transplantation (alloHCT) to patients. In an embodiment, a therapeutic composition for alloHCT includes at least first and second populations of isolated CD45+ cells (ICC). At least a portion of the CD45+ cells in the first population may have an antibody bound to a marker on the cell surface which is used to separate CD34+ cells from a mixture of nucleated cells (MNC) from donor or invitro produced blood. The MNC may comprise various cell types in various amounts, for example, about 70% CD34+ cells, less than about 5% CD3+ cells and less about 20% granulocytes. The ICC&#39;s in the second population include regulatory T cells which are typically at least about 50% of the population. Embodiments of the disclosure are particularly useful for treatment of hematologic cancers (e.g., leukemia, lymphoma), sickle cell anemia, GVHD, autoimmune and other diseases.
PROBLEM TO BE SOLVED: To obtain a hair care cosmetic capable of imparting luster, glow and gloss to hair and excellent in a hair-protecting effect against UV light. SOLUTION: This hair care cosmetic is compounded with inorganic compound particles having a refractive index of &gt;=1.8. The inorganic compound particles are preferably titanium dioxide particles or inorganic oxide particles containing the titanium dioxide, and includes the particles of TiO2 -SiO2 , TiO2 -Al2 O3 , TiO2 -ZrO2 , TiO2 -SiO2 -ZrO2 , and TiO2 -SiO2 -Al2 O3 . The average particle diameter of the inorganic oxide particles is 1-100nm, especially 2-80nm. When the average particle diameter is &gt;100nm, the particles are often unevenly adhered to hair, and can not impart naturally beautiful luster to the hair. When the average particle diameter is &lt;1nm, the stability of the particles themselves is lowered, and the dispersibility of the particles into the cosmetic is deteriorated.
A DSSE architecture network enables multi-user such as data owners and data users to conduct privacy-preserving search on the encrypted PHIs stored in a cloud network and verify the correctness and completeness of retrieved search results simultaneously is provided. The data owners and data users may be patients, HSPs, or combination thereof. An IoT gateway aggregates periodically collected data into a single PHI file, extract keywords, build an encrypted index, and encrypt the PHI files before the encrypted index and PHI files are transmitted to a cloud network periodically for storage thus enable the DSSE architecture network to achieve a sub-linear search efficiency and forward privacy by maintaining an increasing counter for each keyword at the IoT gateway. Since the PHI files are always transmitted and added/stored into the cloud storage over the cloud network, file deletion, file modification is eliminated. The cloud network therefore does not need to learn whether the newly stored PHI files contain specific keywords. Any number of HSPs such as data users provides healthcare services for the patient by searching, querying, and/or retrieving user&#39;s encrypted PHIs incrementally stored on the cloud network in a privacy and verifiable manner. The patient delegated verifiability is derived from a combination of a Bloom filter and aggregate message authentication code.
Retinal degenerative diseases affect the delicate layer of retina tissue that lines the inside back of the eye leading to gradual vision loss. The use of opioid anatgonists for the preparation of a medicament for the selective blocking of the body&#39;s opioid receptors sites is a method of treating this human suffering by daily administration to the patient of from about 0.5 to about 10 mg of drugs such as naltrexone, naloxone or nalmefene. They act primarily by normalizing derangements in the human complement system that may occur in the disease etiology. Therapeutical approach for macular degeneration and retinitis pigmentosa is primarily intended. Oral, parenteral uses as well as topical applications may all be considered. They may be administered in one or divided doses daily for the best receptor blocking activity, preferably in the evening hours. Low Dose Naltrexone suitable for oral administration is most preferred regimen at about 4.5 mg/day.
A new drug---&#34;shining pearl&#34; drop pills for quick acting heart tesurrection used to treat coronary heart disease and angina pectoris etc. is involved in the invention. The procedure to make the pills is as follows: medicinal materials of chuanxiong rhizome, and red sange root are cut into pieces with thickness 2-4 mm. The amount of these two kind of pieces are taken according to prescription description, then mixed evenly and extracted 2 times by using 60% alcohol, first time, 6 times alcohol is added, to reflux for 3 hours the second and third time, 4 times alcohol is used and reflux for 1 hour. Filtering these extracted liquids, putting them together, reducing pressure to recover alcohol and concentrate the matter into paste, which is dried and crushed into powder and sifted out. Boneol is crushed into powdered sifted. Musk is ground into powder in a mortar. The drop pills are produced finally after mixing these three powders fully with the extract from chuanxiong rhizome and red sange root, then this mixture being put together into dissolved carbowax. The pill provides efficiency of promoting blood circulation to dispel blood stasis, regulating of qi and the blood, etc. It can also apply to prevention and cure of angina, myocardial infarction, a stuffy feeling in the chest, short breath. It has features with easy to use, taking effect quickly, high curative ratio and short curing period.
The invention relates to a traditional Chinese medicine composition for treating suppurative skin diseases, which is prepared from the following raw material medicines in parts by weight: dandelion, common andrographis herb, wild chrysanthemum flower, weeping forsythia and purslane. The invention also provides application of the composition in preparing a medicament for treating purulent dermatosis and a preparation method of the medicament. Its advantages are: 1. on the basis of the combination of dialectical and disease differentiation, the raw material medicines are selected according to the principle of &#39;dialectical cause seeking and cause checking and treatment&#39; in traditional Chinese medicine, the dialectical is accurate and complete, the symptoms and root causes are treated simultaneously, and the dandelion and the forsythia are added in the formula, so that the effects of detoxifying and treating sores are achieved, the traditional Chinese medicine is used for treating carbuncles caused by heat toxin accumulation and red swelling and hot pain, and the curative effect is excellent. 2. The components of the traditional Chinese medicines and the proportion thereof are screened by experiments, and the traditional Chinese medicine has the advantage of remarkable effect. 3. The extraction and purification process is optimized, a water extraction and alcohol precipitation process is adopted, and the process parameters such as the optimal extraction temperature, the solvent adding amount, the heating time and the like are selected, so that the obtained medicine extract has high rate.
FIELD: medicine, pharmacology, dermatology, cosmetology. SUBSTANCE: new preparation is suggested for apoptosis rate increase in tumor cells, in pre- tumor cells and thymocytes. Such preparation is represented by an agonist-ligand specific for RAR-γ,- type receptors. The method enables to increase the number of medicinal preparations to treat and prevent the cancer, decrease effects resulting in transplant&#39;s detachment. Moreover, the present innovation could be used to prevent and treat skin aging. EFFECT: higher efficiency of therapy. 12 cl, 2 ex, 1 tbl