anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
NEW MATERIAL:A polyacetylene compound of formula I (R is -CH2OCOCH3 or formyl). EXAMPLE:2Z, 9Z-Pentadecadiene-4,6-diyne-1-yl acetate. USE:It is useful as a drug such as antiallergic, anti-inflammatory, or circulatory drug, because it has 5-lipoxygenase inhibitor and cyclooxygenase inhibitor activity. It can be orally given. PREPARATION:For example, crude drug, &#39;SAIKO&#39;, its original plant, MISHIMASAIKO (Bupleuram facatum L.) or a similar plant is extracted with a solvent such as hexane, and the solvent is distilled off. The remaining is fractionated by chromatography of cellulose column as a carrier using a solvent such as hexane as an eluent to collect the compound of the formula. In another process, a kind of polyacetylene is acetylated to give the subject compound.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a system capable of selectively and efficiently processing only a part of an object to be processed at a molecular level without influencing the object to be processed by combining a tra-hertz wave with other energy supplying means.  &lt;P&gt;SOLUTION: In this system, when an object is irradiated by a tera-hertz wave with an intrinsic frequency of the object to be irradiated, a position to be irradiated is set to prescribed temperature by cooling/heating means. Irradiating an electromagnetic wave with a prescribed frequency, the tera-hertz wave irradiation system irradiates the object by a prescribed mode. Applying a prescribed voltage, the tera-hertz wave irradiation system irradiates an object by a prescribed mode. Applying a prescribed magnetic field, the tera-herts wave irradiation system irradiates an object by a prescribed mode. Applying a prescribed dynamic stimulation, the tera-herts wave irradiation system irradiates an object by a prescribed mode. Supplying prescribed enzymes etc., the tera-hertz wave irradiation system irradiates an object by a prescribed mode. The system uses these manners in a combination. The tera-hertz wave irradiation system uses an optimally structured metallic antenna to widen the action of a tera-hertz wave.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
PURPOSE:A mild remedy for hyperpigmentation disease, acting selectively on melanine-forming cell, showing improved decoloring effects, comprising cysteinylphenol, cysteiaminylphenol, or its derivative as an active ingredient. CONSTITUTION:A remedy containing cysteinylphenol or cysteiaminylphenol shown by the formula (R is cysteinyl or cysteiaminyl) or its derivative as an active ingredient. To be concrete, 4-S-cysteinylphenol, 2-s-cysteinylphenol may be cited as the derivative. The compound shown by the formula is milder than hydroquinone, acts selectively one a melanine-forming cell, and shows improved decoloring effects. The compound shown by the formula is usable in the form or cream, lotion, ointment, etc., by a conventional procedure. It is also effective against hyperpigmentation diseases such as chloasma facial, melasma. Addition&#39;s disease, etc.
NEW MATERIAL:A neutral saccharide-containing luteinized hormone containing &gt;=18% of the neutral saccharide chain component in the saccharide chain component composition of the beta-subunit thereof. USE:A kidney growth-accelerating agent. PREPARATION:For example, a swine pituitary is homogenized in an ammonium sulfate aqueous solution, adjusted to a pH of 3.0 and centrifuged to collect a supernatant solution, which is adjusted to a pH of 6.5-7.0, mixed with ammonium sulfate to become 0.5 saturation, cooled and centrifuged. The resultant precipitates are collected, suspended in a buffer solution, dialyzed and subsequently lyophilized. The lyophilized powder is dissolved in a buffer solutions and fractionated with ConA-sepharose column to collect a fraction eluted with 0.2M methylmannoside. The fraction is purified with a column for isoelectric point electrophoresis to provide a kidney growth factor.
PROBLEM TO BE SOLVED: To obtain a composition for coating teeth, instantly curing in the oral cavity, providing a coating film of small thickness having antimicrobial activity itself. SOLUTION: This coating composition is obtained by dissolving 10-100 pts.wt. of a shellac in 100 pts.wt. of &gt;=50% ethyl alcohol solution to give a solution of shellac in alcohol and dissolving one or two of 0.001-30 pts.wt. of a basic amino acid and 0.001-30 pts.wt. of a pH adjuster in the solution and can provide a surface having lost tack immediately after curing and showing a lubricant sensation.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a new antiseptic, especially the antiseptic expressing excellent antiseptic action when used for water-based compositions such as an ophthalmic agent and the like, and a water-based composition provided with excellent antiseptic action.  &lt;P&gt;SOLUTION: The antiseptic comprises (A) at least one species of compounds selected from diphenhydramine, chlorpheniramine or their salts combined with (B) boric acid and/or a boric acid salt. The antiseptic is prepared by combining 1 pt.wt. diphenhydramine or its salt as the total amount and 0.5-10,000 pts.wt. boric acid and/or its salt as the total amount, or 1 pt.wt. chlorpheniramine or its salt as the total amount and 0.5-10,000 pts.wt. boric acid and /or its salt as the total amount.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a novel family of enzymes.  &lt;P&gt;SOLUTION: The invention relates to the discovery of a novel family of enzymes designated in specification concerned as mRNA interferases that exhibit endoribonuclease activity. The novel finding presents new applications for which mRNA interferase nucleic and amino acid sequences, and compositions thereof may be used to advantage. The invention also includes screening methods to identify compounds/agents capable of modulating mRNA interferase activity and methods for using such compounds/agents. There is also provided a kit comprising mRNA interferase nucleic and/or amino acid sequences, mRNA interferase activity compatible buffers and instruction materials.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
Adenocarcinomas display and circulate immunosuppresive mucins such as epiglycanin. Pretreatment with cyclophosphamide or other suppressor T cell-inhibitory agents enhances the specific immune response to a synthetic glycoconjugate presenting the T-alpha hapten. Tumor-bearing mice received this tumor vaccine formulation were able to achieve approximately 90 % long-term survival (&gt; 90 days). When mice were treated with the same vaccine formulation without cyclophosphamide, 25 % survival for the same length of time was observed. Many surviving mice had good delayed-type hypersensitivity responsiveness to the synthetic conjugate and among them a few also had good IgG antibody titer against the same conjugate. Upon further intraperitoneal challenge with 1 x 104 live Ta3-Ha tumor cells, approximately 30 % of the surviving animals which had been pretreated with the complete vaccine formulation were still able to sustain long-term survival or complete care. Circulating immunosuppressive mucins may also be removed by pheresis.
&#34;LATEX NAIL COATING&#34; Hector J. Gonzalez and Janiana Z. Pilch ABSTRACT OF THE DISCLOSURE An aqueous latex nail coating emulsion of copolymers of at least three monomers and methods of formulating such coating are disclosed. One monomer comprises at least one or .beta. mono ethylenically unsaturated mono or polycarboxylic acid monomer having from 3-10 carbon atoms. A second monomer comprises at least one ethylenically unsaturated ester. The third monomer comprises at least one additional monomer of an ethylenically unsaturated ester other than the last mentioned ester monomer, a monovinylidene, a vinyl ester or an acrylamide. Emulsifying agents may be added to emulsify these monomers in the aqueous emulsion and at least some of these emulsifiers may be copolymerizable with the monomers. Following copoly-merization, a salt of a di- or trivalent metal is added to the emulsion for crosslinking the copolymers. Following copoly-merization, one or more alkali soluble resins, plasticizing agents, coalescing agents, antifoaming agents, viscosifying agents, leveling aids and pigments may also be added, as desired, to form the nail coating.
PURPOSE:To retrieve and extract picture data or approximate picture data related to original picture data stored in a large capacity device easily and rapidly by adding plural additional information to plural picture data and retrieving and extracting the picture data related to optional added information or the approximate picture data of said picture data. CONSTITUTION:An operator commands a retrieval request by operating a console to write the original picture data of a subject in a memory 23. When the original picture data is read out, the data is displayed on a screen part of a display screen 26 of a CRT 25. Then, the operator operates the console 28 to display a relative picture corresponding to the original picture number on the screen part of the CRT 25. In this case, the original picture data is retrieved by using the additional information of the original picture No. &#39;&#39;1&#39;&#39; as its key word through a large capacity memory 29 and a controller 31 which are operated on the basis of a control command from a CPU 30. Namely, relative picture No.s &#39;&#39;1-123&#39;&#39; corresponding to the original picture No. &#39;&#39;1&#39;&#39; are retrieved on a picture retrieval table in the order of 1-m of related degree on the basis of the coincidence of comparison of the original picture No., additional information, picture data location, etc.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a composition wherein sterilizing power and/or detergent power of a chlorous acids compound are considerably enhanced.  &lt;P&gt;SOLUTION: This water-based composition contains a chlorous acids compound, glycerol, and a phosphoric acid compound. The water-based composition is used for a sterilizing solution for contact lenses, an antiseptic solution for contact lenses, a washing solution for contact lenses, a rinsing solution for contact lenses, or a saline solution for contact lenses. The water-based composition is used for a multi-purpose solution for contact lenses. The water-based composition is used for an ophthalmic solution, in particular, an ophthalmic solution for dry eyes.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
The present invention provides an improved process for preparing modafinil, whereby it may be isolated in high purity by a single crystallization. The process produces modafinil free of sulphone products of over-oxidation and other byproducts. The invention further provides new crystalline Forms II-VI of modafinil and processes for preparing them. Each of the new forms is differentiated by a unique powder X-ray diffraction pattern. The invention further provides pharmaceutical compositions containing novel modafinil Forms II-IV and VI. ® KIPO &amp; WIPO 2007
The invention discloses a bandage with an application tape for pelvic floor dysfunction. Belongs to the technical field of medical appliances. The method comprises the following steps: the bandage main part of &#34;worker&#34; style of calligraphy, paste part, pubis calibration reference point, solid fixed ring can dismantle and apply ointment or plaster. The medicine in the detachable application comprises the following raw materials: raw astragalus, fructus psoraleae, fructus alpiniae oxyphyllae, mantis egg-case, semen cuscutae, cherokee rose fruit, cinnamon, dendrobium officinale extract, carbomer gel and propylene glycol. The invention realizes the comprehensive treatment of the pelvic floor dysfunction by comprehensive application of biomechanics and pharmacology. Under the action of maximum external force, the closed reduction of the pelvic floor within 30 days reaches 90%, and the supporting effect of I type collagen of rectus abdominis and pelvic floor muscles and the tissue elasticity of III type collagen are effectively improved through the transdermal absorption of the medicine application. Can obviously improve the mechanical property of the pelvic floor support structure and repair the rectus abdominis, pelvic floor muscles and connective tissues.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a skin ageing-improving cosmetic which contains the extracts of a relaxing action galenical (Lilium brownii F. B. Brown varcolchesteriWils), a blood flow-improving action galenical (Paeonia suffruticosa Andr bark), and a water distribution-leveling action (Paeonia lactiflora Pall), as main action ingredients to improve the outstanding wrinkle or looseness states of aged face skins, further selectively contains galenical ingredients to increase the proper skin ageing-improving effects, and can surely improve the aged skin state.  &lt;P&gt;SOLUTION: This skin ageing-improving cosmetic is characterized by containing the extracts of the relaxing action galenical (Lilium brownii F. B. Brown varcolchesteri Wils), the blood flow-improving action galenical (Paeonia suffruticosa Andr bark), and the water distribution-leveling action galenical (Paeonia lactiflora Pall). Further, on the basis of the discrimination of a prominent aged skin state as an index, the extracts of a relaxing action galenical such as Pueraria pseudo-hirsuta Tang et Wang, and/or a blood flow-improving action galenical such as Phellodendron amurens Rupr, and/or a water distribution-leveling action galenical such as Astragalus menbranaceus Bge are added to enable a proper skin ageing improvement.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
FIELD: medicine. 
     SUBSTANCE: invention refers to medicine, namely to - arthrology, physiotherapy, balneology. The method involves physical methods of therapy, therapeutic exercises, massage, acupuncture and phytotherapy. The patients are trained to give a self-massage of the knee joints additionally during the resort therapy and after the termination of the rehabilitation. From the 1 st  to 10 th  day of the therapeutic course patient&#39;s knee joint is exposed to polychromatic polarised light at 20 cm for 6 minutes. The patients take 10 iodine-bromine baths at temperature 37°C for 10 minutes. From the 1 st  to 5 th  therapeutic days, the patients do combined therapeutic exercises; their lower extremities are massaged manually for 10 minutes. From the 6 th  to 15 th  days, the knee joints are exposed to sinusoid modulated currents (SMC) at modulation frequency 100 Hz, at a depth of 50 - 70%, current intensity to moderate vibration for 7 minutes. From the 6 th  to 10 th  days, the braking acupuncture follows by giving a 1-2-minute massage of the points 10RP, 9RP, 36E, 34E by introducing a needle for 30 seconds and by giving a point massage of cheng-fu, cuan, yang-lin-cuan, zu-sang-li, wei-yang, cheng-shan, chung-feng, hun-lun, nei-ting. The patients take a herbal infusion. From the 11 th  to 15 th  days, the knee joints are exposed to decimetric waves (DMW). That is followed by a hydro-massage of the lower extremities and lumbar region for 15 minutes up to 3 atm. Thereafter, the 10-minute post-isometric relaxation of the quadriceps muscle of thigh is applied. The patients do the complex of weight reduction exercises and take the herbal infusion. From the 16 th  to 20 th  day, the mud applications on the knee joints are prescribed at temperature 42°C for 30 minutes. If suffering gonarthrosis, the patients do the complex of therapeutic exercises. That is followed by the paravertebral vacuum therapy of the vertebral column. The 10-minute knee joint traction is applied. The patients take 20 g of the herbal infusion. 
     EFFECT: method recovers the joint mobility, improves the exercise tolerance of the lower extremities. 
     1 tbl, 2 ex
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for producing Tensho Hurora water.  &lt;P&gt;SOLUTION: Metasilicate mineral spring water in compliance with hot springs law, Article 2. Appendix, can be obtained artificially by mixing Tenshoseki and fluorite ore with raw water such as running water, spring water, or underground water which can be used as drinking water and by heating the mixture up to (90-100°C). The metasilicate mineral spring water as drinking water can go through the fifty prescriptions of the water quality standard, which is good to drink even when cold, but gets thickened like Kudzu vine water when warmed. The water also has a moisturing effect for a hair and a skin and a good effect on a skin cure such as an insect bite, eczema, or atopic dermatitis. Such water containing much metasilicate for drinking and moisturing can also be produced by mixing the raw water with fluorite ore, Bincho charcoal, or rocks having a high far infrared emissivity and a high measured amount of minus ions, and then by heating the mixture. Hereafter we can make such mineral water at homes and institutions and enjoy a mood in a hot spring.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
The present invention relates to nanosilver-containing antibacterial and antifungal granules (“NAGs”). The NAGs have longlasting inhibitory effect on a broad-spectrum of bacteria and fungi, which include, but are not limited to,  Escherichia coli , Methicillin resistant  Staphylococcus aureus, Chlamydia trachomatis, Providencia stuartii, Vibrio vulnificus , Pneumobacillus, Nitrate-negative bacillus,  Staphylococcus aureus, Candida albicans, Bacillus cloacae, Bacillus allantoides , Morgan&#39;s bacillus ( Salmonella morgani ),  Pseudomonas maltophila, Pseudomonas aeruginosa, Neisseria gonorrhoeae, Bacillus subtilis, Bacillus foecalis alkaligenes, Streptococcus hemolyticus  B, Citrobacter, and  Salmonella paratyphi  C. The NAGs contain ground stalk marrow of the plant  Juncus effusus  L. which has been dispersed with nanosilver particles. The nanosilver particles are about 1-100 nm in diameter. Each of the nanosilver particles contain a metallic silver core which is surrounded by silver oxide. The present invention also provides a process for making the NAGs. The NAGs can be used in a variety of healthcare and industrial products. Examples of the healthcare products include, but are not limited to, ointments or lotions to treat skin trauma, soaking solutions or cleansing solutions for dental or women hygiene, medications for treating gastrointestinal bacteria infections, sexual related diseases, and eye diseases. Examples of industrial products include, but are not limited to, food preservatives, water disinfectants, paper disinfectants, construction filling materials (to prevent mold formation).
&lt;P&gt;PROBLEM TO BE SOLVED: To provide fermented black garlic extract liquid and fermented black garlic powder each as a fermented black garlic processed product obtained by subjecting raw garlic to self-fermentation, causing no garlic smell on expiration after eaten, and excellent in bioactivation: to provide a method for producing the processed products: and to provide food and drink containing the liquid or the powder.  &lt;P&gt;SOLUTION: The fermented black garlic extract liquid comprises fermented black garlic extract obtained by causing self-fermentation on raw garlic. The fermented black garlic powder comprises dried and pulverized fermented black garlic obtained by subjecting raw garlic to self-fermentation. The products comprising the fermented black garlic extract liquid or the fermented black garlic powder are obtained by aging the raw black garlic at 55-80°C in a humidity of 70-95% to subject the raw black garlic to self-fermentation. The method for producing the fermented black garlic extract liquid and the fermented black garlic powder each comprises a process of subjecting raw garlic to self-fermentation, a process of forming the obtained fermented black garlic into pasty one, a process of extracting the pasty fermented black garlic and a process of condensing the extract.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide drug-containing micro-particles having a small particle diameter and effectively inhibiting bitterness and controlling elution properties of the drug even when the coating amount is small and to provide a method for producing the micro-particles.  &lt;P&gt;SOLUTION: The drug-containing micro-particles having 10-100 μm average particle diameter are produced by coating drug particles having 1-25 μm average particle diameter during flowing with a coating liquid containing a water-insoluble polymer with 10-50 μm average mist diameter under 0.1-0.3 MPa spray pressure. Cellulose ethers and acrylic acid-based copolymers can be used as the water-insoluble polymer. The spraying ratio of the coating liquid based on 100 pts.wt. of the drug particles is 0.02-0.6 pt.wt./min converted into solid contents.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
Described herein are fluorinated poly(lactic-co-glycolic acid) polymers (&#34;PLGA&#34;). Also described herein are fluorinated PLGA nanoparticles, drug encapsulated fluorinated PLGA nanoparticles, and corresponding dispersions. Relative to corresponding non-fluorinated PLGA nanoparticles, the fluorinated PLGA nanoparticles have desirable  19 F nuclear magnetic resonance (&#34;NMR&#34;) activities and concomitant relaxation times for use as  19 F magnetic resonance imaging (&#34;MRI&#34;) probes. It was surprisingly found that, for some fluorinated PLGA nanoparticle embodiments, the  19 FNMR activity (and therefore the  19 FMRI activity) could be tuned ( e.g.  turned on an off) by changing the pH of the nanoparticle dispersion. It was also surprisingly discovered that the  19 FNMR activity could also be tuned by adjusting the relative concentration of the polar organic solvent to water in the formation medium, as described in detail below. Because the fluorinated PLGA nanoparticles include, by definition, fluorine, dmg loading and encapsulation efficiency is also significantly increased for fluorine containing drugs, relative to corresponding non-fluorinated PLGA.
1434044 Resin-drug composites BIOREX LABORATORIES Ltd 2 July 1974 [17 July 1973] 34040/73 Headings C3A C3P C3R and C3U [Also in Divisions C2 and D1] The invention comprises pharmaceutically active pentacyclic triterpenes which have been immobilized by chemical attachment to a polymeric organic or inorganic carrier; and their preparation by reacting the triterpene with the carrier, either of which may be chemically activated as appropriate. Specified triterpenes are glycyrrhetinic, 3-dehydroglycyrrhetinic, oleanolic, 11-oxo-oleanolic and ursolic acids and the hemisuccinates, hemiglutarates and amides thereof, and hederagenin. The examples relate exclusively to glycyrrhetinic acid hemisuccinate which may be activated by reaction with isobutyl chloroformate. The carrier may be a polysaccharide, e.g. agarose, a cross-linked dextran, starch, cellulose or cellulose acetate, these being activated by successive reactions of the diol system thereof with cyanogen bromide and 1,6-hexanediamine (R = hexamethylene). The carrier may also be chloromethylated &#34;hydrocarbon&#34; beads (activated by reaction with 1,6 - hexanediamine) chloromethylated polystyrene beads (unactivated), nylon (activated by reaction with 3-(dimethylamino)- propylamine), polyacrylamide (activated by diazotization followed by reaction with 1,6- hexanediamine), polyethylene terephthalate or ethylene-maleic anhydride copolymer (activated by reaction with 1,6-hexanediamine and cyclohexylcarbodiimide) or polyvinyl alcohol (activated by reaction with p-nitrobenzoyl chloride followed by reduction of the nitro group to amino with sodium dithionite).