anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PCT No. PCT/EP94/04230 Sec. 371 Date Aug. 18, 1995 Sec. 102(e) Date Aug. 18, 1995 PCT Filed Dec. 14, 1994 PCT Pub. No. WO95/18091 PCT Pub. Date Jul. 6, 1995   &lt;IMAGE&gt;  (I)  The invention relates to compounds of formula (I), R1 and R2, each independently of the other, are selected from lower alkyl that is unsubstituted or substituted by one or more fluorine atoms which are not linked to the carbon atom of R1 or R2 bonding the nitrogen; from lower alkenyl wherein the double bond does not originate from the carbon atom that is bonded to a nitrogen bonding R1 or R2; from lower alkynyl wherein the triple bond does not originate from the carbon atom that is bonded to a nitrogen bonding R1 or R2; from cycloalkyl; and from cycloalkyl-lower alkyl; with the proviso that not more than one of the two radicals R1 and R2 is methyl; or salts thereof. The mentioned compounds are pharmacologically active against disorders that are responsive to a recuction in intracellular polyamines, such as tumours or protozoal diseases.
The present invention relates to an edible product for enhancing immunity. Some efforts have been made to make food/medicament composition from natural sources. Still there is a need for an edible product or food supplement which provides for improving immunity within the people to fight against these common diseases and develop a &#39;self prevention&#39; and self treatment system within them. It is an object of the present invention to provide an edible product which enhances immunity by using a polysaccharide other than what has been disclosed in the art. The present inventors have surprisingly found that an edible product comprising a polysaccharide (derived from one or more plants belonging to the family of Camellia sinensis var. sinensis and/or Camellia sinensis var. assamica) other than what has been disclosed in the art which is comprised of galacturonic acid is particularly useful in modulating immune response.
Disclosed is a method for characterising tinnitus in a subject. The method comprises receiving data comprising cortical activity data indicative of cortical activity in one or more regions of the subject&#39;s brain, and cardiac activity data indicative of cardiac activity in the subject, at a processor device. The cortical activity data is derived from one or more functional near-infrared spectroscopy (fNIRS) signals. The received data is processed using the processor device by inputting feature values into a model, where the feature values include one or more features of the cortical activity data and one or more features of the cardiac activity data. The model is configured to provide one or more classification results based on the feature values, the classification results being indicative of at least one characteristic of tinnitus in the subject. Also disclosed is a system for applying the disclosed method.
PROBLEM TO BE SOLVED: To provide a process for producing a vitamin K supplement compsn. for food having a high vitamin K content without the occurrence of problems in safety and palatability in spite of addition of this vitamin to the food by a relatively simple processing method using natural materials as raw materials and a method for extracting the vitamin K having no possibility of remaining and forming (denaturation) of harmful materials. SOLUTION: The leaf parts of dark green and yellow vegetables having green leaf blade parts are used as the materials to be treated and are heated to soften the plant tissues and, thereafter, the leaf parts are subjected to a solid liquid sepn. of liquid mesophyll parts, solid petile parts and veinparts, thereby the compsn. consisting of the mesophyll parts and having the high vitamin K content is obtd. According to another method for production, the dry matter of the leaf parts is pulverized and the pulverized matter is classified to the mesophyll parts, the petiole parts and the vein parts to separate the dry matter of the mesophyll parts. The vitamin K content of the resulted compsn. is &gt;=1000μm per 100g.  The selective extraction of the vitamin K is made possible if the dark green and yellow vegetables are extracted by using liquid carbon dioxide existing in a supercritical state.
PURPOSE:To provide a physiologically active substance useful for preventing and treating hypertension, hyperlipidemia and obesity, comprising a thermally unstable component extracted from Polyporales grifola or Tricholomo flammulina. CONSTITUTION:A physiologically active substance containing as a main ingredient a protein extracted and separated from the fruit body or hypha of Aphyllophorales Polyporaceae grifola or Agaricales Tricholomataceae flammulina exhibits vasodepressor activity, serum lipid lowering activity and body weight decreasing activity and is employed as an active ingredient for the preventing and treating agent of hypertension, hyperlipidemia and obesity. For example, the fruit body of the Polyporales grifola is dried, crushed and extracted with water. The extract solution is vacuum-concentrated as such or at &lt;=40 deg.C and lyophilized. The product is passed through a column to adsorb an active ingredient, which is eluted with sodium chloride fractionated by a chromatography to provide the active ingredient. Since the active ingredient is thermally unstable, the active ingredient is processed into a granular or tablet-like food or drug, alcoholic drink, medicated wine, tea-like drink, etc.
PROBLEM TO BE SOLVED: To obtain the subject composition enabling to directly administer a liquid oral cavity composition into an oral cavity and god in usability by charging the liquid oral cavity composition into a specific container. SOLUTION: This composition for oral cavities is obtained by charging a ligquid oral cavity composition into a container equipped with an extrusion nozzle and enabling to directly administer the liquid composition into the oral cavities through the nozzle. The liquid composition for the oral cavities comprises e.g. 0.001-20wt.% of an antifungal agent and/or an antibacterial agent [e.g. a compound of the formula (A&lt;m+&gt; is an antimuicrobial nitrogen-containing cation; the counter anion X&lt;-&gt; is a 8-20C linear or branched monoalkyl phosphate ion, a monoalkenyl phosphate ion, etc.; (m) is the valency of the cation A)], a perfume (e.g. spearmint oil), a water-soluble fluoride compound (e.g. sodium fluoride), an alcohol (e.g. ethanol), a humectant, etc., and, if necessary, a surfactant and/or a defoaming agent, an oval cavity vehicle, etc.  The extrusion nozzle preferably has an inner diameter of 0.5-4.5mm, an outer diameter of 2-10mm, and a length of 5-60mm.
PURPOSE:To provide a skin cosmetic or making fair skin, e.g. beauty wash, cream, milky lotion, pack, etc., by using a compound such as sodium diethyldithiocarbamate, ammonium pyrrolidinedithiocarbamate, etc. as a component. CONSTITUTION:The objective skin-whitening cosmetic contains 0.01-1% compound of formula (R and R&#39; are lower alkyl or together form lower alkylene; M is alkali metal or ammonium). The compound of formula is a colorless and odorless substance having high safety and easily soluble in water and alcohol. It is free from side effects undesirable to the human body, and suppresses the formation of melanin pigment causing the dark skin.
PURPOSE:To obtain a detergent compsn. which has a high detergency, hardly irritates or injures the skin, can be washed away easily and is excellent in feeling during use by compounding high-molecular particles having a specified particle size, particle size distribution, and specific gravity into the compsn. CONSTITUTION:The detergent compsn. contains high-molecular particles having a mean particle size of 50-500mum, a coefficient of variation of particle size of 25% or lower, and a specific gravity of 1 or lower. A mean particle size lower than 50mum gives an insufficient detergency; one higher than 500mum causes a sense of incongruity and skin irritation. A coefficient of variation higher than 25% requires a large amt. of particles to be compounded to obtain a sufficient detergency, resulting in problems such as skin irritation, a sense of incongruity, and coming into an eye. A specific gravity higher than 1 makes the removal of the particles from the skin or eye during washing difficult and sometimes causes a sense of incongruity. The particles pref. have a modulus of elasticity of 1X10&lt;3&gt;-5X10&lt;5&gt;dyn/cm&lt;2&gt; in terms of irritation and injury to the skin.
PURPOSE:To prepare fine inorganic oxide particles having improved various characteristics, by adding a mixed solution containing a specific organosilicon compound and a metallic compound to an alkaline solvent, hydrolyzing the compounds, and depositing the reaction product. CONSTITUTION:An hydrolyzable organosilicon compound, e.g. an alkoxysilane, and a hydrolyzable organic compound of a metal selected from Group III in the periodic table, e.g. Al, B or Y, are added to an alcoholic solution and mixed. The resultant mixed solution is then added to an alkaline solvent, capable of dissolving both organic compounds, but incapable of dissolving the reaction product to hydrolyze both organic compounds. Thus, the aimed fine particulate inorganic oxide, having 0.1-10mum particle diameter, &lt;=1.30 standard deviation value of the particle diameter distribution, &gt;=100m&lt;2&gt;/g specific surface area and &lt;=20mol% composition ratio of the above-mentioned metallic oxide, consisting essentially of the silica and metallic oxide, and widely usable is obtained.
FIELD: cosmetology, balneology, pharmaceutics, food industry. SUBSTANCE: the method deals with separate preparing formula&#39;s foundation and concentrate of nutritive and biologically active components, its total osmotic activity being not less than 2000 mOsm/l due to introduction of osmotic activity regulators and containing homogenate of drone bee brood, or spermatic homogenate and/or roe of gray sea urchins, and either caviar and/or sperm of ascidia and soft roe and/or fish caviar, or cock&#39;s sperm, or homogenate of poultry embryos and/or components of poultry eggs, or whole mammalian colostrum, or homogenate of Bivalvia gonads, or male and/or female gonads of mussels, or nutritive medium obtained from cellular culture of human leukocytes and/or animal leukocytes being at the stage of logarithmic growth. The mentioned parts of preparation should be packed and kept separately: the foundation - at room temperature, concentrate - either at room temperature or in refrigerator. Right before application these mentioned parts of preparation should be mixed at certain quantitative ratio. The method enables to store the product under positive temperatures at no usage of any biocidal additives. EFFECT: higher efficiency. 8 cl, 20 ex
Method and system for the analysis and source localization of the dynamical patterns in medical and health data, and linking such dynamical patterns with the individual&#39;s genetic and/or molecular data. The invention makes use of optimally positioned sensors (sensor arrays) providing input data for signal processing, time-series analysis, pattern recognition and mathematical modeling to facilitate dynamical tracking of systemic arterial pressure without a pressure cuff, local vascular activity, electrocardiographic (ECG), respiratory, physical, muscular, gastrointestinal and neural activity, temperature and other physiological/health data. The invention also facilitates separation of local signals (such as local aneurisms or local vascular activity) from non-local, central or systemic patterns (e.g. systemic blood pressure). In addition, the invention improves identification of dynamical patterns associated with a specific genotype/disorder for screening, personalized risk assessment, diagnosis and treatment control. The system can be implemented in a specialized processor, such as an ambulatory blood pressure monitor, Electrocardiograph, Holter monitor located outside subject&#39;s body or implanted inside the body, mobile/cell phone or Smart Phone/Personal Digital Assistant, computer or computer network (the Internet), including wireless or mobile network. The system can be also linked to the electronic health/medical records and other databases.
FIELD: veterinary medicine. SUBSTANCE: method deals with improving the immune status of iron deficiency anemia in farm animals. For this purpose, animal is given a preparation of complex compounds of zinc and iron and unrefined caned sugar at 0.5-4 ml/kg body weight. For the treatment, 1-mo-aged calves and piglets are given the preparation once daily for 10-15 d up to normalization of hemoglobin level. The method enables to normalize the immune status due to metabolic restoration and decrease the expenses for animals&#39; treatment. EFFECT: higher efficiency. 1 cl, 2 tbl
The present invention describes reagents and methods for using a concatemerized double-stranded oligonucleotide molecules (CODN) for transcription factor decoys. In one embodiment, the concatemers consist of a variable number of end-to-end repeated copies of a short (more than 5, 10, 15, 20, 2, 3035, 40, 45, 50, 75, 100, or more by but generally less than about 3 kb) dsDNA containing a sequence or sequences that act as transcription factor decoys. The present invention also provides for the use of the polymers for CODN/polymer complexes to a specific cell type; thus the agent can be made organ, tissue and/or cell-type specific. In another embodiment, the present invention provides for use of the CODN&#39;s in vitro or in vivo, in isolated cells or intact animals in which specific blockade of transcription factors or delivery of DNA or other biological effector is desirable. In one embodiment, this includes use as a research tool, including studies of specific genes and studies to identify specific genes regulated by the transcription factors targeted. In another embodiment, the present invention provides for using polyamides for NF-kB-specific CODN delivery in the treatment of myocardial ischemia/reperfusion and myocardial infarction, heart failure and hypertrophy, cardioprotection, stroke, neuroprotection, sepsis, arthritis, asthma, heritable inflammatory disorders, cancer, heritable immune dysfunctions, inflammatory processes, whether caused by disease or injury or infection, oxidative stress to any organ whether caused by disease, surgery or injury. The decoys may be any transcription factors, including, but not limited to, NF-kB, AP-I, ATF2, ATF3, SP 1 and others.
Pharmaceutical compositions comprise one or more compounds of general formula &lt;FORM:0863719/VI/1&gt; wherein R represents hydrogen or an alkyl, alkenyl, aralkyl, acyl or carbamyl radical and wherein X and Y which may be the same or different, are hydrogen or one or more halogen atoms or cyano radicals together with non-toxic excipients. The compositions may be in conventional pharmaceutical forms, e.g. plain and coated tablets and pills, aqueous dispersions, oily suspensions or emulsions, sterile dispersable powders, parenterally-acceptable forms, e.g. sterile aqueous suspensions or sterile oily emulsions, such forms containing conventional diluents, lubricating, granulating, binding, suspending, dispersing and emulsifying agents.  Many examples of compounds of the above general formula are given, those preferred being 2 - phenylbenzamide; 2 - (p - bromophenyl) - 5-bromobenzamide and 2-(p-bromophenyl)-5-chlorobenzamide.  The Provisional Specification refers to compounds of general formula &lt;FORM:0863719/VI/2&gt; wherein R is hydrogen, or a hydrocarbon or acyl radical. Specification 859,342 is referred to.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for preparing a pharmaceutical composition containing a GPR119 agonist having activity of GIP (glucose-dependent insulinotropic polypeptide) secretagogue.  &lt;P&gt;SOLUTION: The invention relates to a method of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual. Agonists of the GPR119 receptor are useful as therapeutic agents for treating or preventing a state characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. The agonists of the GPR119 receptor promote bone formation in an individual. In a certain embodiment, the individual is a human.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
PURPOSE:To produce easily a finely divided chitin suspension which is stable only by mechanical operation without using any chemical agents, by treating a coarsely powdered chitin suspension with a high-pressure homogenizing apparatus. CONSTITUTION:A high-pressure homogenizing apparatus is used which is operated in such a manner that a suspension which is caused to flow into a valve device 1 in the direction of an arrow is passed through a small-diameter orifice 3 between a valve seat 2 and a valve 4 to apply pressure to the suspension and to rapidly accelerate it and is made to collide with a collision ring 5 to rapidly reduce the speed. Chitin obtd. from crab or shrimp, refined and crushed to small pieces (the longest being 1-2mm.) is dispersed in water (concn. being 10wt% or below). The suspension is introduced into the homogenizing apparatus and passed therethrough while applying a pressure of at least 200kg/cm&lt;2&gt;, pref. 350- 560kg/cm&lt;2&gt; to the suspension. By repeating this stage, a chitin suspension is produced in which the content of the stabilized suspension is at least 50% after 0.5wt% suspension having a water retention value of at least 200% is left to stand for one hr.
A dentrifice comprises a water-soluble chlorophyll derivative and a polishing agent mixture including a calcium or magnesium phosphate or carbonate and a water-insoluble salt of a polymetaphosphoric acid, which may contain up to 4 per cent. of water-soluble polymeta phosphates.  The dentrifice contains 0.01 to 2.0 per cent. chlorophyll (based on pure chlorophyll derivative) and (a) for tooth pastes 50 to 60 per cent polishing agent (b) for tooth powders 95.5 to 98 per cent. polishing agent, is preferred. 5 to 50 per cent of the insoluble polymeta phosphate is replaced by the other polishing agents.  The dentrifice is buffered at pH 6 to 7.  Specified chlorophyll derivatives are chlorophyllins, isochlorophyllins, pheophorbides, phytochlorins and phytorhodins prepared from natural chlorophylls a and b e.g. sodium and potassium magnesium chlorophylls, sodium and potassium copper or iron chlorophyllins; chlorophyll extracts preferably of 70 to 100 per purity; chlorophyll preparations containing the sodium and potassium salt of the copper, magnesium or iron complexes of phytochlorin e and phytorhodin g. Preferred polymetaphosphoric acid salts are the water-insoluble alkali metal salts especially those of sodium or potassium e.g. Maddress salt and Kurrol&#39;s salt.  Specified essential polishing agents are calcium carbonate, magnesium carbonate, dicalcium phosphate, tricalcium phosphate, dimagnesium phosphate and trimagnesium phosphate.  Optional ingredients are (a) other polishing agents e.g. bentonite, kaolin, ground bone meal, calcium sulphate, alumina gel, pumice, silica, whiting, tin oxide, hydrated magnesia, magnesium trisilicate, magnesia and talc; the wetting agents e.g. soap, diglycol laurate, diglycol stearate, sulphonated alcohols e.g. sodium lauryl sulphate, sulphonated oils and glycostearin; (c) buffers; (d) flavouring and sweetening agents e.g. saccharin; (e) preservatives (f) oxygen releasers such as puborates; (g) binders such as gum acacia and tragacanth, Indian gum, Irish moss, agar agar starch, locust bean gum, silica gel, pectin, clays and petrolatum; and (h) carriers and softeners such as water, glycerin, ethyl alcohol, mineral oil, syrup, glucose, invert sugars, glycols and honey.  Specification 601,801 is referred to.
PROBLEM TO BE SOLVED: To obtain a new compound, capable of manifesting excellent antiemetic actions based on strong antagonistic actions on serotonin S3 and dopamine D2 receptors, having low toxicity and useful as an antiemetic agent. SOLUTION: This (R)-5-bromo-N-(1-ethyl-4-methylhexahydro-1H-1,4-diazepin-6- yl)-2-methoxy-6-methylamino-3-pyridinecarboxamide represented by formula I or its acid addition salt. The compound is obtained by reacting, e.g. a compound represented by formula II with (R)-6-amino-1-ethyl-4-methylhexahydro-1 H-1,4-diazepine represented by formula III. The compound represented by formula II is prepared by starting from, e.g. 2,6-difluoropyridine and the compound represented by formula III is a new substance and is obtained from, e.g. N&#39;- methyl-N-(3-methylbenzyl)ethylenediamine. Furthermore, the reaction is preferably carried out by using 1mol compound represented by formula II and 1-1.5mol compound represented by formula III.
The present invention relates to skin cream for treating intractable dermatoses, which belongs to the technical field of medicine. The technical problem which needs to be solved is to provide the skin scream for treating intractable dermatosis for treating chronic eczema, eczema rhagadiforme, neurodermatitis, amyloidosis, Hyde&#39;s disease and psoriasis. The medicine mainly comprises more than ten kinds of ingredients, such as clobetasol propionate, mentholum, etc. The present invention has the main action that the present invention can treat intractable dermatoses which are frequently suffered by middle-aged people and the elderly, such as, chronic eczema, amyloidosis, etc., which are usually seen in both lower extremities. If patients use the medicine of the present invention, the patients can be restored to original conditions within no more than one month. The present invention has the advantages of no cracking, no itching, lichenification annihilation, normal presentation of local skin, permanent effect by long use and no medicine tolerance. The curative ratio of the present invention can achieve more than 95 %.
PURPOSE:To obtain an external preparation of skin for improving chapped skin by blending a blend of a steroid glycoside and/or triterpenoid glycoside and sphingoglycolipid with a steroid hormone at a specific ratio and adding an anti-inflammatory agent, cell-activating agent, humectant, etc., thereto. CONSTITUTION:The objective external preparation of skin containing a steroid glycoside (e.g. campesteroid glycoside) and/or triterpenoid glycoside (e.g. cycloartenol glycoside) and (B) a sphingoglycolipid (e.g. monohexosylceramide) at an amount of 0.0005-90wt.% based on the total amount (at a weight ratio of the ingredient A/the ingredient B of 90/10 to 10/90) and further containing a steroid hormone at an amount of &lt;=0.5% based on the total amount. The external preparation of skin can recover regularity of arrangement of keratin cells and improve chapped skin by normalizing and retarding turnover of skin keratin layer. The chapped skin-improving effects are further enhanced by adding an anti-inflammatory agent, cell activating agent, lipoperoxide-producing inhibitor, humectant, etc., thereto.
A hair rejuvenating lotion applied to a user&#39;s hair to treat and relieve symptoms caused by seborrheic dermatitis. Through use of plant extracts and other supplemental active ingredients, the hair rejuvenating lotion restores hair to a healthy condition, retains color and prevents hair loss. The plant extracts included are from the genera  echinops, alchemilla, staphylea,  and  scorzonera,  as well as the plants  sophora japonica  and nettle. The other supplemental active ingredients include sulfur, ammonium chloride, lead acetate, and castor oil. The base of the hair rejuvenating lotion consists of distilled water, glycerin, and ethyl alcohol. The plant extracts from the genera  echinops, alchemilla, staphylea, scorzonera  are dissolved into the ethyl alcohol to create a tincture solution. The tincture solution is mixed with the distilled water, glycerin, sulfur,  sophora japonica  extracts, nettle extracts, ammonium chloride, and castor oil to form the hair rejuvenating lotion.