anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
&lt;P&gt;PROBLEM TO BE SOLVED: To improve convenience when inspection data related to a specimen are captured into a server.  &lt;P&gt;SOLUTION: An inspection data capturing apparatus 70 acquires inspection data from an analyzer 80 via a communication network N2. Then, the inspection data capturing apparatus 70 acquires a patient ID based on an operation signal by user operation from an operation unit. Then, the inspection data capturing apparatus 70 transmits an acquisition request for patient attribute information with the patient ID as a retrieval condition to a medical image server 40, an inspection data management server 60, an electronic medical chart server 30 and the like. Then, the inspection data capturing apparatus 70 acquires patient attribute information matching the retrieval condition. The inspection data capturing apparatus 70 adds the acquired patient attribute information as an identifier to the inspection data. The inspection data capturing apparatus 70 transmits (outputs) the inspection data as HL7-compliant specimen inspection result data to the inspection data management server 60.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PURPOSE:To provide the titled water-based coating liquid, by dispersing an alkali metal salt of an acid having a specific acid dissociation constant and a specific water-insoluble hydroxycarboxylic acid cellulose derivative as essential components in water or an aqueous solution of an alcohol. CONSTITUTION:The objective enteric coating liquid is produced by dispersing (A) an alkali metal salt of an acid having an acid dissociation constant (pKa) of &gt;=3 at 25 deg.C (e.g. acetic acid) and (B) a water-insoluble hydroxycarboxylic acid cellulose derivative of formula (Glu is glucose anhydride unit of cellulose and represented by C6H7O2; R1 is H or 1-5C carboxyalkyl; at least one of R2 and R3 is carboxy, etc. when R1 is H) (e.g. carboxymethylethylcellulose) as essential components in (C) water or an aqueous solution of an alcohol containing &lt;=20 wt% 1-3C lower alcohol. The objective water-based enteric coating liquid can be produced highly economically and safely.
The present invention describes the application of specifically derived stress proteins in the modulation of certain specific immune responses in the human and animal body. This application under certain conditions may require the in vitro (out of body) treatment of certain tissues (including cells of all lineages) derived from the intended recipient body or specific donor body, in the case of organ or cell transplantation. The intracellular activity and the subsequent protection against mortality in a cell or tissue has been described in another U.S. patent, U.S. Pat. No. 5,348,945 entitled &#34;Method of treatment with HSP70&#34;. The present invention differs from the aforementioned patent in that it does not describe a method for non-specific or specific protection against mortality. The invention may be employed to suppress allograft rejection and the rejection of xenografts, transplanted into human and/or animals.
NEW MATERIAL:The compound of formula I [X is H, halogen or lower alkyl; R is (substituted) alkyl, (substituted) naphthyl or heteroaryl] or its salt. EXAMPLE:(+ or -)-trans-3-(2-Chloro-3-hydroxyphenyl)-4-(3,4-dihydroxyphenyl)pyrrolidine hydrobromide. USE:A drug. A remedy and preventive for diseases to which dopamine 1 agonist action is effective. A remedy and preventive for hypertension or remedy and preventive for cardiac insufficiency. PREPARATION:The trans-isomer of the compound of formula I can be produced by adding a compound of formula IV (R&lt;6&gt; is OH-protecting group; R&lt;7&gt; is lower alkyl) to a compound of formula V to produce a compound of formula VI as an addition reaction product, reducing the compound to a compound of formula VII, cyclizing the product to obtain a compound of formula VIII, isomerizing to a transisomer, reducing the isomer and finally removing the protecting groups.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a new elastase inhibitor derived from a natural substance having high safety, a skin care preparation for external use and a health food both containing the same.  &lt;P&gt;SOLUTION: The elastase inhibitor is an elastase inhibitor containing an extract of pine bark, especially the elastase inhibitor containing an extract of pine bark obtained by extraction with hot water has high effect. The skin care preparation for external use is obtained by using the extract that is also useful due to its moisture retaining effect. The health food is obtained by using the extract. Since the elastase inhibitor is derived from the natural substance, the skin care preparation for external use and the health food using the elastase inhibitor are safe ones.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a simple method for producing a super mineral material by which the super mineral components in a clean state without contamination are gathered from a natural world at a low cost entirely without hazard.  &lt;P&gt;SOLUTION: This method for producing the super mineral material comprises adding citric acid to a rock pulverized into a granular shape, or soaking the pulverized rock in the citric acid to elute the super mineral components. The rock pulverized into the granular shape preferably has a cube shape of about 3 mm size, and the rock pulverized into the granular shape is previously heated for several hours. Preferably, the heating is boiling with hot water. An original water of a hot spring having a strong acidity and an efficacy of a medicine is preferably added to the eluted super mineral components.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
Clearing the free radicals in the body and suppressing the specific marker MAO-B&#39;s activity are the special dedication to human being by American scientists. Defering senility and raising life quality are the original pursue of the human being, and looking for a drug for deferring senility is the American dream for long. The four plant compound wares use the WLD resin for absorption, elution and separation and purifying the plant component under the careful and strict condition. Quatity measure with high efficiency liquid phase chromatography meter ensure the equal and stable product. The pharmacological experiment show that the four plant compound wares have the pharmacological activities of raising SOD activity in the old moice&#39;s livers, increasing SOD content in the blood notably, supressing MAO-B&#39;s vitality significantly, adding up the catalase vitality in the erythrocyte. It gets to the unimagble effect. The extensive use of the compound wares in the medical domain is according to its pharmacological activity.
1480189 Mixing screws BAYER AG 4 April 1975 [6 April 1974] 53147/75 Divided out of 1480187 Heading B1C [Also in Division B5] A melt-spraying device for the production of granules of phenacetin comprises intermeshing self-cleaning screws 3, 4 mounted for rotation in the same direction in a heated housing, the clearance between adjacent parts of the screws and of the housing being 4-30 x 10&lt;SP&gt;-3&lt;/SP&gt; times the screw diameter, a spray nozzle, and a heated pump for feeding melt from the heated housing to the spray nozzle. Water or steam are passed through a heating jacket 9 and cooling fluid through a jacket 8 at the inlet 5 to prevent premature melting. The screws 3, 4 may be heated. The heated surfaces may be much hotter than the temperature to which the phenacetin is heated due to the short residence time e.g. at from 150 to 303C. The molten phenacetin at 140C is passed through a line 10 (Fig. 1 not shown) and pumped by a piston pump (11) through a vortex nozzle 12 to be atomised and acidified in air or water at 20C.
The risk with introducing manipulated T-cell is unforeseen adverse events. During the development of chimeric antigen receptor (CAR) T-cell therapies almost all clinical trial has shown some adverse events ranging from cytokine mediated toxicities to tissue damage and death. By the present invention, we aim to induce multiple layers of safety checkpoints. As a last resort we will be able to induce suicide in all cells which we have introduced to the body. Here we describe the scientific background to the parts of our suicide switch and the details regarding the proteins which are included. Safety switches are being tested on CAR-T cells, but they have a few drawbacks. Due to the limited space on the CAR vector, there is only room for one gene switch. Presently the results show they induce apoptosis in around 70-90% of cells, while the desired target is for all cells to be removed from the tissue. By utilising the space available on a synthetic chromosome, we can include multiple genes under Tet operons which allow us to turn multiple genes on/off. Life or death of a cell depends on the balance of the pro and anti-apoptotic proteins. The scale is always shifting a bit back and forth but only when tipped completely over the apoptotic cascade is initiated. By fine tuning the balance we aim to ensure that the hSync carrying cells have a survival advantage in the tumour in the absence of inducing agent. On the other hand, the moment that agent is administrated the cells will undergo apoptosis and express &#34;find me&#34; and &#34;eat me&#34; markers making sure they are removed without risk of tissue damage. The present invention encompasses compositions and methods for use in cellular gene therapeutics using a modular approach to genetically engineer cells to carry a synthetic chromosome having a regulatable system including one or more safety switches.
The invention provides a sunscreen formulation including conventional UVB  sunscreening agents and zinc oxide having an average particle size in the order of 150 to 800 nm. Preferably the zinc oxide used is pigment grade. Most preferably, zinc oxide prepared by the French process is used, although that produced by the American process is also suitable. The average particle size of the zinc oxide is most preferably in the order of 200-400 nm. Throughout this specification, the term &#34;pigment grade&#34; is used to define zinc oxide that has been produced by the French or American process. A further embodiment of the invention is a method of reducing or preventing the harmful effects of solar radiation on skin by applying the inventive sunscreen formulation. A  further embodiment of the invention relates to a sunscreen composition having a sun protection factor greater than 30 including zinc oxide having an average particle size of 150 to 800 nm. A still further embodiment of the invention relates to a sunscreen composition which is susbstantially transparent upon application to the skin including zinc oxide having an average particle size of 150 to 800 nm.
The invention discloses an orally disintegrating tablet containing Istradefylline and a preparation method thereof. The tablet contains a water-soluble filler, a binder, a disintegrating agent, a lubricant, and an odor mask. A solid dispersion technology is employed to improve the taste. The tablet has the characteristics of good taste, good oral compliance, rapid onset, and is applicable to the treatment of Parkinson&#39;s disease. The invention also provides a preparation method. The method has simple process and low cost, and belongs to the medical technical fields of medical science and pharmacy.
A method for decreasing nicotine and other substance use in humans is disclosed. Tetrahydroberberine (THB) and its analogs, l-Tetrahydropalmatine (l-THP) and l-Stepholidine (l-SPD), are present in and can be isolated from several plants in the Magnoliidae superorder. According to the disclosed method, THB and its analogs are used to block nicotine-induced DA release, and modulate heterologous or homoeric expression of human nicotinic acetylcholine receptors (nAChR) in humans. Specifically, THB exhibits bi-directory modulation of α4β2-nAChR-mediated currents induced by nicotine. THB also shows predominant inhibition on homologously expressed α7-nAChR function. Thus, according to the disclosed method, THB is used to simultaneous blockade midbrain DA system function, the brain reward center, and neuronal α4β2- and α7-nAChR function, the major nicotine targets in the brain. Therefore, THB and its analogs serve as a novel class of natural compounds to decrease nicotine dependence in humans. Furthermore other substances, such as alcohol, cocaine, and opiates, also operate by triggering the brain reward center, resulting in a cycle of substance or alcohol abuse. THB and its analogs can be used to decrease use of substances such as alcohol, cocaine, and opiates. Finally, because THB and its analogs are DA antagonists, THB and its analogs can also be used as a treatment for Parkinson&#39;s Disease, Alzheimer&#39;s Disease and Schizophrenia.
Carotenoid compositions of enhanced solubility and bioavailability are described that contain at least one carotenoid with at least one solubility-enhancing polymer. In one embodiment, the carotenoid is a provitamin A carotenoid such as β-carotene. In another embodiment the carotenoid is a non-provitamin A carotenoid such as lycopene or lutein. Described methods to produce the bioenhanced products include dry blending and solvent spray drying. In accordance with certain embodiments of the invention, the method includes the steps of providing a mixture comprising the carotenoid, a solubility-enhancing polymer and a solvent and removing the solvent to produce an amorphous form of the carotenoid. Products made by the invention&#39;s compositions and methods include pharmaceuticals, nutraceuticals, cosmetic, and personal care products for man and animal.
PURPOSE:To obtain the titled growth promoting adjuvant water, consisting of silver ion water at a specific pH or below and ion concentration within a specific range, having soil improvement, control of pathogenic germs, etc., as well as growth of symbiotic germs, growth and maturing promotion, etc., of fruits and useful as growth promoting adjuvant water for cultivating plants, e.g. field crops, etc. CONSTITUTION:Growth promoting adjuvant water, consisting of Ag ion water having &lt;=5pH and 30-2,000ppb Ag&lt;+&gt; ion concentration and useful for cultivating plants, e.g. field crops, etc., particularly growth promoting adjuvant water consisting of Ag ion water having 350-2,000muV/cm&lt;3&gt; electric conductivity and 12-30ppm dissolved oxygen content and useful for cultivating plants, e.g. field crops, etc. The Ag ion water is safe for the human body without danger such as agricultural chemicals and growth of resistant germs against bacteriostatic effect of the Ag ion. The above-mentioned adjuvant water is capable of remark ably growing parts of plant roots, thickening leaves and stems and promoting the growth and maturing of fruits to increase the yield.
PURPOSE:To obtain the titled contrasting agent capable of constantly giving a satisfactory contrast echo, by using a perfluorocarbon emulsion having a specific particle diameter as a main component. CONSTITUTION:A perfluorocarbon (e.g. perfluorodecalin, perfluoro-N- methyldecahydroisoquinoline, etc.) is added to a prescribed amount of a salt solution containing 1-6%(W/V), preferably 2-5% main emulsifier such as phospholipid, polymeric nonionic surfactant (preferably having a molecular weight of 2,000-20,000), etc. The mixture is agitated by a mixer to obtain a rough emulsion liquid, which is converted to the objective emulsion having particle diameter of 1-10mum, especially 2-5mum by emulsifying with an emulsifier under an emulsifying pressure of 5-50kg/cm&lt;2&gt; at 50-60 deg.C for 1-30min. The amount of the perfluorocarbon is selected to give the objective emulsion containing 2-100% perfluorocarbon. The emulsion can pass through capillary vessel of lung, develops a contrast echo even at left ventricle and is usable as a myocardial contrast echo agent for the diagnosis of ischemic part of cardiac muscle by intraaortic infusion.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a diagnostic reading support apparatus capable of facilitating the input work of a diagnostic reading report, keeping the degree of freedom of input and performing highly accurate retrieval.  &lt;P&gt;SOLUTION: In the diagnostic reading support apparatus 10, an aneurysm candidate is detected from an inputted head part image in a candidate detection part 16 and the feature amount of the aneurysm candidate is calculated. A control part 11 generates index information made to correspond to the feature amount and stores it in an information analysis system DB 21. Also, the control part 11 generates a template sentence of the diagnostic reading report using the feature amount, corrects the template sentence corresponding to correction input and generates diagnostic reading report information using the corrected sentence. The generated diagnostic reading report information is made to correspond to the index information and stored in a job system DB 22.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
Alopecia means that hairs abnormally or excessively fall out, and reasons are numerous. When mental pressure is excessive, incensement of hairs lost can frequently occur. Under the action of mental pressure, arrector pili muscle of human body is contracted, hair follicle papilla changes and is malnourished, hairs enter a resting phase, and alopecia occurs. Endocrine abnormality can further cause alopecia, such as postpartum alopecia and climacteric alopecia. Malnutrition of body and pathobolism can further cause change of hair quality and hair color. The drug is prepared by combining dragon&#39;s bone, American ginseng ganoderma lucidum, hairy antler, broom cypress, whitebackleaf mallotus root, oriental wormwood, deer-horn gelatin, chinaberry fruit, pcuises and testes of an ursine seal, flower bud of lilac daphne, gecko, fruit of Chinese magnoliavine, Chinese caterpillar fungus, black sesame, yeradetajo, walnut meat, mulberry, cynomorium, radix rehmanniae preparata, indianmulberry, actinolite, epimeddium, cuscuta chinensis, curculigo rhizome, flatstem astragalus seed, bark of eucommia, bitter cardamom, radix dipsaci, psoralea fruit and drynaria, and the drugs are combined to ensure that efficacies of all the drugs generate a synergistic action, so that alopecia can be effectively treated.
PURPOSE:To provide an antitumor composition composed of 5-fluoro-2&#39;-deoxy-beta- uridines and a thymidine compound, having a reduced side effects keeping the antitumor effect of the uridine compound. CONSTITUTION:The objective antitumor composition is produced by compounding the 5-fluoro-2&#39;-deoxy-beta-uridines of formula I [R&#39; is acyl; R2-3 are (protected) OH] with thymidine compound of formula II [R&lt;4&gt; is H or acyl; R&lt;5-7&gt; is (protected) OH]. The amount of the thymidine of formula II is 0.3-8mol, preferably 0.5-5mol per 1mol of the compound of formula I . The side effect of the compound of formula I , e.g. the disorder of digestive organs, etc. can be mitigated while keeping the antitumor activity of the compound of formula I , by using the thymidine compound of formula II together with the compound of formula  I . Furthermore, the toxicity of the compound of formula I can be mitigated.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a photopolymerizable composition having a low polymerization shrinkage and excellent fluidity even when the compounding ratio of an inorganic filler is relatively high in order to provide excellent mechanical properties of a cured product after curing, and suitably usable as a flowable composite resin.  &lt;P&gt;SOLUTION: This dental photopolymerizable composition comprises 100 pts. mass of a polymerizable monomer, 100-400 pts. mass of the inorganic filler and an effective amount of a photopolymerization initiator. In the dental photopolymerizable composition, ≥60 mass% of particles having ≥0.03 to &lt;0.1 μm particle diameter in the inorganic filler are silica-zirconia spherical inorganic oxide particles.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
FIELD: medicine. SUBSTANCE: this medicine named &#34;Retrovir&#34; is competitive inhibitor of reverse transcriptase. This drug administered in case of viral hepatitis B reduces activity of DNA-polymerase and retards synthesis of DNA minus chain. Consequently, this medicine steps down replicating activity of hepatitis B virus, which is accompanied by rapid disappearance of intoxication syndrome, reduction of icteric period, normalization of biochemical processes, disappearance of superficial antigen, and shortening of hospitalization period. Data obtained point to the fact that disclosed drug produces positive therapeutic effect when administered in dose of 660 mg/day and 750 mg/day to patients suffering from moderately severe form of acute viral hepatitis B. EFFECT: excellent means for treating acute viral hepatitis B. 3 tbl
The invention &#34;use of biomarker or biomarkers combination in preparing a diagnostic reagent for fulminant myocarditis and a drug for fulminant myocarditis&#34; belongs to the field of disease diagnostic reagents and drugs. The use is characterized in that the biomarker comprises Siglec-5. The biomarkers combination is further selected from the group consisting of sST2, PAI-1, Siglec-5, CD163, CD40, P-Cadherin, CD14, CTLA4. The invention finds that the levels of the biomarker in plasma of patients with fulminant myocarditis is increased, and proves that the biomarker plays a role in diagnosing fulminant myocarditis and a role as a drug target in relieving and/or improving fulminant myocarditis. The level of the biomarker can be detected to forecast or auxiliary diagnose fulminant myocarditis or estimate prognosis of fulminant myocarditis. Meanwhile, level of the biomarkers is controlled through drugs, more intensified diagnosis and follow-up treatment can be carried out on diseases, and the biomarkers have huge clinical application value.
The invention relates to the milk of a transgenic non-human mammal. The milk is characterized in that it contains heterologous components produced as the secondary gene products of a heterologous gene contained in the genome of the transgenic non-human mammal. The heterologous gene encodes a heterologous catalytic entity such as a human enzyme selected from the group consisting of glycosyltransferases, phosphorylases, hydroxylases, peptidases and sulfotransferases. Especially useful in the practice of the invention are human glycosyltransferases. The desired heterologous components include oligosaccahrides, glycoconjugates. Specifically exemplified, is the production of 2&#39;-fucosyl-lactose in the milk of transgenic mice which contain and express a transgene encoding α-1,2-fucosyltransferase operatively linked to a mammary gland specific promoter. The oligosaccahrides and glycoconjugates may be isolated from the milk of the transgenic mammals and used in the preparation of pharmaceuticals, diagnostic kits, nutritional products and the like. The whole transgenic milk may also be used to formulate nutritional products that provide special advantages. The transgenic milk may also be used in the production of specialized enteral nutritional products.