anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
The present invention provides solid crystalline forms of apomorphine free base or a hydrate, solvate, or co-crystals thereof. Such crystalline forms may be advantageous over amorphous forms of apomorphine,  e.g. , amorphous salt forms such as acid addition salts of apomorphine, because of their increased/greater stability and/or improved pharmacological properties,  e.g. , decreased adverse reactions at the site of administration. The invention further provides liquid formulations obtained by dissolving said crystalline forms of apomorphine in a solvent, as well as a method for treatment of a neurological or movement disorder,  e.g. , Parkinson&#39;s disease, or a condition associated therewith, by administration of said liquid formulations.
&lt;P&gt;PROBLEM TO BE SOLVED: To prevent a medical accident, especially an accident caused by a misidentification of patients.  &lt;P&gt;SOLUTION: An electronic medical chart comprises a personal identification function part, a personal information storage function part, and a medical device information exchange function part. The personal identification function part comprises a biometrics sensor and a central processing unit. At least biometrics information for personal identification and personal health information are stored in the personal information storage function part. The central processing unit compares the biometrics information obtained by the biometrics sensor and the biometrics information for personal identification. When the two match, information exchange between the medical device information exchange function part and an external medical device is made possible in a predetermined period, whereby the personal health information is read by the external medical device, or the personal health information is updated by the external medical device.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
PURPOSE:To provide an agent for imparting excellent iridescent luster to cosmetics, and keeping the luster stably for a long period even at a high temperature, by using a straight-chain alkanediol diester as a main component. CONSTITUTION:The objective iridescent luster agent contains at least one compound of formula (R and R&#39; are 13-23C straight-chain alkyl; n is integer 3-10) pref. having a melting point of &gt;=50 deg.C. The agent gives very beautiful and thermal- ly stable iridescent luster to liquid or pasty cosmetics such as shampoo, rinsing agent, lotion, cream, etc., by conventional compounding process. The use of a mixture of two or more kinds of the above compounds or the use of a compound wherein R is different from R&#39; gives more desirable iridescent luster than the use of a  compound wherein R is R&#39;. Since larger molecular weight of R and R&#39; results in  higher melting point of the compound, desired thermal stability according to the purpose can be attained by selecting proper R and R&#39;.
An oral analgesic composition comprises harmine (7 - methoxy - 1 - methyl - 9 - pyrid [3,4-l]indole) of formula &lt;FORM:0970894/A5-A6/1&gt; and an extract of red Cinchona bark.  The harmine may contain up to 10% of hydrogenated harmine, e.g. 3,4-dihydro harmine or tetrahydro harmine, and may be synthetic or extracted from Banislleria coapi spruce (family malpighiaceae).  The stems of the plant are powdered, extracted with dilute hydrochloric, acetic or sulphuric acid and active material precipitated by adding ammonia to pH 7.5 to 11.5. The Cinchona extract is obtained by extracting the bark with 80% ethyl alcohol and evaporating to dryness.  The solids are preferably mixed with starch and filled into capsules.
PURPOSE: A pharmaceutical composition for injection and a method for manufacturing the same are provided to control pH and/or bivalent cation concentration and to reduce patient&#39;s pain. CONSTITUTION: A pharmaceutical composition for injection comprises: a water soluble particle containing alkali earth metal or alloy or compounds of the alkali earth metal; and biocompatible fluid. The pharmaceutical composition has an activity of controlling pH or bivalent cation concentration. The alkali earth meal is Be, Mg, Ca, Sr, Ba, or Ra. The alloy is combination of two or more kinds of Be, Mg, Ca, Sr, Ba, or Ra. The compounds are oxide, hydroxide, sulfur oxides, or chloride of the alkali earth metal. The pharmaceutical composition is used for treating and preventing bone damage, osteoporosis, rheumatitc arthritis, or Paget&#39;s disease.
The present invention provides methods of treating a coronavirus, COVID-19 disease. COVID-19 disease is caused by the coronavirus, SARS-COV-2.Treatment of the SARS-COV-2 infection could be achieved by administering a single element or a combination of elements in the protocol of therapies comprising of1) A laxative2) A Nutritious Meal followed by a cup of green tea, raw honey, lemon. milk and a dessert of pear d&#39;anjou and strawberries3) Administering drugs and vitamins. These drugs could be anti-parasitic, antiviral, antibacterial and/or immunomodulatory.4) Providing for the subject infected with the SARS-COV-2 to enjoy the treat of a plain water hot bathtub bath. Some Epsom Salt should be added to the plain water hot bathtub bath. The subject should be encouraged to spend at least 30 minutes in the hot bathtub bath.5) A Physical Exercise session.6 Claims, 0 Drawing Sheets.
The invention belongs to the field of antisense nucleic acid medicaments, and relates to a macrophage inflammatory protein (MIP) 3 alpha antibody to nuclear antigen (ANA) 6 and preparation thereof to the preparation of immunosuppressive medicaments. The immune response of an organism plays a key role in autoimmune diseases and the exclusive reaction of the transplantation of organs and tissues. The invention provides the antisense nucleic acid molecule MIP3 alpha ANA6 used for preparing the immunosuppressive medicaments. The MIP3 alpha ANA6 is a double-stranded nucleic acid molecule. The sense strand of a DNA sequence of the MIP3 alpha ANA6 is 5&#39;-ATATATTGTGCGTCTCCTC-3&#39;, and an antisense strand is 5&#39;-GAGGAGACGCACAATATAT-3&#39;. Under the condition of culture with the addition of inflammatory cytokines, the MIP3 alpha ANA6 can remarkably reduce many kinds of cell expressing MIP3 alpha mRNA and generating MIP3 alpha proteins, and functions in immunosuppression by suppressing antigen presenting cells and T cells. The invention provides the novel antisense nucleic acid medicament for treating MIP3 alpha-related immune diseases.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a medicine for improving or preventing (A) diarrhea and/or (B) digestive symptoms due to intestinal abnormal fermentation, characteristic to sugar alcohols taken as medicines or foods.  &lt;P&gt;SOLUTION: One or more polysaccharides are compounded as an active ingredient in a constant ratio to sugar alcohols or separately taken to reduce or eliminate side effects consisting of (A) diarrhea and/or (B) digestive symptoms, such as gastrointestinal symptoms, due to intestinal abnormal fermentation, characteristic to the sugar alcohols, as main complaints. The characteristics of the polysaccharides are utilized, and the two or more polysaccharides are combined. Both an antidiarrheic action and an intestinal function-controlling action can simultaneously be realized in a smaller amount than that in a case using a polysaccharide singly. The medicine can be changed into a form capable of being easily taken.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To obtain a cosmetic composition by incorporating a Bertholletia extract so as to promote collagen VII synthesis and/or vitamin C intake into the chrotoplast. SOLUTION: This composition contains, as active ingredient, 0.0001-1 (pref. 0.01-0.25)wt.% of an extract from Bertholletia belonging to the genus Lecythidiaceae, a kind of tree found in South America. The extract promotes esp. epidermis-corium conjugation for collagen VII secretion by normal subject&#39;s epidermal keratinocytic culture, also having transport effect of vitamin C into the chrotoplast, esp. fibroblast, thus being useful as cosmetic, medicinal, esp. dermatological composition. Furthermore, the extract is incorporated at 0.1-10μg/mL into a cell culture medium, esp. human chrotoplast culture medium to prepare a cell culture fluid composition. The extraction is carried out by the use of water, methanol, ethanol, or a mixture thereof.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an external preparation for skin having enhanced antipruritic actions and moisture retention and to provide a method for enhancing the antipruritic actions and moisture retention of the external preparation for the skin.  &lt;P&gt;SOLUTION: The external preparation for the skin having the further enhanced antipruritic actions of an antipruritic agent and moisture retention of hyaluronic acid is obtained as follows. A tocopherol derivative is further used with the external preparation for the skin prepared by formulating the hyaluronic acid and the antipruritic agent and having remarkably suppressed drying of skin and pruritic feeling in combination. The method for enhancing the antipruritic actions and moisture retention by using the tocopherol or its derivative, hyaluronic acid or its salt and the antipruritic agent in combination is provided. The external preparation can be applied to any sites if in the case of the skin and can suitably be used even in delicate sites with a thin horny layer of the skin and easily affected by irritation or affected regions subject to high humidity.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
PROBLEM TO BE SOLVED: To easily produce a glucide containing trehalose having a refined and good sweetness, properties for regulating an osmotic pressure, a formativeness, moisture retention, properties for preventing precipitation of other glucide, etc., in high yield by allowing a maltose-trehalose converting enzyme to act on a solution containing sucrose. SOLUTION: This glucide containing trehalose is obtained by allowing a maltose-trehalose converting enzyme to act on a solution containing sucrose. An enzyme produced by a microorganism such as Pseudomonas putida H262 (FERM BP-4579) is preferably used as the before maltose-trehalose converting enzyme. The objective glucide containing trehalose is obtained by allowing the maltose-trehalose converting enzyme, preferably &gt;=10 unit enzyme per gram solid, to act on the solution containing sucrose. The content of the trehalose is preferably increased by allowing an invertase to act on the liquid obtained by the enzymatic reaction and further treating the resultant liquid with a column chromatography by using a salt-type strong acid cation exchange resin.  Moreover, the reaction under the maltose-trehalose converting enzyme is preferably performed at 0-70 deg.C and within the pH range of 6-8.5.
PURPOSE:To obtain a spicy liquor, containing an extract of the whole herb and petals of Impatience balsamina L. as an active ingredient, having excellent analgesic and anti-inflammatory effects on ruptured disks, herniated disks, rhenmarthritis, etc., and a food containing the spicy liquor. CONSTITUTION:A spicy liquor containing an extract of the whole herb, that is leaf, stem and root and petals and seeds of Impatience balsamina L. as an active ingredient is presented. Examples of alcohols used for preparing the herb and petals as the spicy liquor include ethanol, brewed liquor, distilled liquor, blend liquor and synthetic liquor. The aforementioned spicy liquor is preferably produced by mainly utilizing the whole herb and petals of the Impatience balsamina L., ethanol with &gt;=30 deg. alcoholic strength and distilled liquor. The above-mentioned spicy liquor has the aforementioned characteristics without any odor peculiar to the Impatience balsamina L. or grassy smell.
FIELD: medicine, pharmacy. SUBSTANCE: invention relates to preparing preparation form sea buckthorn (Hippophae rhamnoides L.) leaves with content of gallo-elago-tannins &gt; 20% by method of pre-extraction of vegetable raw with polar organic solvent followed by extraction of end compounds with aqueous organic extractant. From sea buckthorn depleted raw with content of gallo-elago-tannins &gt; 20% active substances are extracted with anhydrous polar extractant, then with aqueous polar extractant followed by additional purification from by-side substances by extraction of aqueous vat residue after removal of extractant with binary mixture of solvents containing aliphatic alcohol and aliphatic hydrocarbon solvent of hexane type. Invention ensures to obtain standard preparation from raw of different types. EFFECT: improved method of preparing. 2 cl, 1 tbl
Disclosed are dry pharmaceutical preparations containing potent steroidal medicinal agents in combination with an excipient capable of binding the agent to an extent greater than 80% and a having a demixing potential of less than 10% for said agent. Such excipients include spray-dried polyalcohols, granulated  alpha -lactose monohydrate, or mixtures thereof. Also disclosed is a process of manufacturing stable tablets containing nearly identical amounts of at least one steroidal medicinal agent present in each tablet in an amount varying from 0.005 to 0.5 percent by weight of the tablet. Also disclosed is a dry mix consisting essentially of 1 to 100 parts, by weight, of at least one medicinal agent uniformly distributed throughout 2000 to 20,000 parts, by weight, of the described excipients. The mixture can be used to make dry dosage forms such as capsules, tablets, powders, and slugged granulates. &lt;IMAGE&gt;
The invention relates to drugs for treating lumbar disc herniation, in particular to a drug for treating the lumbar disc herniation and a preparation method thereof. The drug is formed by taking animal and plant Chinese medicinal herbs as raw materials and solves the problems of being poor in curing effect, curing the symptoms not the disease and the like, of the prior art. The drug comprises the following raw materials in parts by weight: 30-60 parts of rhizoma atractylodis, 50-80 parts of chaenomeles fruit, 50-80 parts of angelica, 50-80 parts of rhizoma dioscoreae, 30-60 parts of dodder seed, 50-80 parts of desertliving cistanche, 30-60 parts of ground beetle, 30-60 parts of dragon&#39;s blood, 50-80 parts of radix astragali preparata, 20-50 parts of pangolin, 30-50 parts of hairy deerhorn, 30-60 parts of panax pseudo-ginseng and 50-80 parts of achyranthes root. The preparation method of the drug for treating the lumbar disc herniation comprises the following steps of: firstly, drying the raw materials, crushing the raw materials into fine powder with the grain diameter of 100-200 meshes, and screening; then, mixing according to proportion, then, carrying out germicidal treatment, and evenly mixing to produce medicaments. The medicaments are water pills, the water pills are dried in shade or medicinal powder is directly encapsulated; or the water pills are prepared into honeyed pills by adding honey. The drug for treating the lumbar disc herniation is prepared by adopting purely-natural animals and plants, so that the drug has the advantages of mild nature, no toxic and side effects and adverse reactions and suitability for long-term medications of patients suffering from the lumbar herniation.
A drug delivery system for oral administration is provided. The drug delivery system includes an oral delivery carrier and a plurality of micelles attached to or dispersed in the oral delivery carrier. Each of the micelles includes a hydrophobic core and a hydrophilic corona targeted to a subject&#39;s kidney. A pharmaceutical payload is carried by the plurality of micelles. Another drug delivery system includes a plurality of micelles and a payload within each micelle. Each micelle has a kidney targeting peptide conjugated thereto with a polyethylene glycol linking group having a molecular weight less than 1800 Daltons.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a bleaching agent and a bleaching cosmetic containing an extract from at least one or more species of plants selected from among Schizandra chinensis Baill., Schizandra repanda (Sieb. et Zucc.) Radlk. and Kadsura japonica Dunal. or Kadsura longipendunculata Finet. et Gagnepen or Kadsura peltigera Rehd.  &lt;P&gt;SOLUTION: The bleaching agent and bleaching cosmetic have inhibitory actions on melanin formation and stability with time of the actions, excretion promoting actions on melanin and excellent bleaching effects and effectively inhibit and ameliorate pigmentation of skin such as dermal stains, ephelides, dullness or skin blackening caused by ultraviolet exposure. The bleaching agent and bleaching cosmetic are extremely highly safe even for human bodies and can be used over a wide range in the fields of medicines, quasi-drugs and cosmetics.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a purified gene encoding cytokine from a mammal, a reagent related thereto including a purified protein and a specific antibody and a nucleic acid encoding the molecule.  &lt;P&gt;SOLUTION: The purified gene encodes cytokine from a mammal. The reagent related thereto includes a purified protein and a specific antibody. The nucleic acid encodes the molecule. The method of using the reagent and the diagnostic kit are also provided. Especially, the composition comprises a combination of interleukin B30 (IL-B30) and IL-12 p40 subunit. The biological activity is provided. The nucleic acid encodes both a polypeptide and a fusion protein. The method for producing and using the same is provided.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
Bust d&#39;Odor Deodorant is a clear liquid roll-on deodorant for men and women with lemon juice and botanical extracts (honeysuckle and orange lemongrass). It is designed to remove strong underarm odor that may last up to 48 hours. There are no antiperspirants, which is the whole objective of this invention. It does not prevent sweating as do antiperspirants, because sweating is good for the human body. To prevent underarm sweat is to keep toxins or waste products in the body; and adding the chemicals in antiperspirants on top of this makes it very dangerous and unhealthy for the human body. This is a breakthrough invention for mankind, health-wise. It has no side effects except for minor itch caused by cuts from shaving. It leaves no residue or gummy, sticky feeling under armpit, and does not stain or discolor clothing.
668,131. Medicinal preparations. GONZALEZ-BARCENA Y FONSDEVIELA, F. Jan. 30, 1950 [Feb. 2, 1949], No. 2348/50. Class 81 (i). An antibiotic effective against hµmophilus pertussis and designated &#34;helicidine&#34; is obtained by extracting the secretions of animals of the mollusca type, such as the helicidµ, beating the secretions in liquid form, treating them with an antiseptic, and drying them to a powder. In the first stage the animals may be stimulated by mechanical, physical or chemical action to produce the secretions or they may be extracted from the crushed mollusca by means of warm water. The antiseptic may be ether, chloroform or a mixture thereof. The drying step may be effected at 60‹ C., the secretions being spread out on a glass plate in a stove. The dried powder may be further treated by dissolving in physiological serum, adding penicillin or other antibiotic, leaving the product to settle at 0-10‹ C. in hermetically sealed receptacles, filtering, heating the filtrate at 30-10‹ C. and then for a shorter period at 45-65‹ C., and finally drying. The process is preferably carried out in a neutral atmosphere and in the absence of air.
PURPOSE: To obtain a skin cosmetic capable of sustainedly manifesting excellent softness imparting effects on a horny layer without deteriorating the normal skin physiology for a long period and further imparting a good feeling of use to the skin without stickiness. CONSTITUTION: This skin cosmetic contains 0.001-50wt.%, especially 0.01-20wt.% guanidine derivative of formula I (formula II is a heterocyclic group selected from azetidine, pyrrolidine, piperidine, piperazine and morpholine; R&lt;1&gt; and R&lt;2&gt; are each H, an alkyl, a hydroxyalkyl, carboxyl, a carboxyalkyl or amidino) or its salt, e.g. N-amidino-L-proline. When an organic or an inorganic acid, preferably a dicarboxylic acid, especially succinic acid is blended in the cosmetic, softening effects can be enhanced. The amount thereof blended is within the range of 0.001-30wt.%. The compound of formula I is obtained by reacting a cyclic amine derivative of formula III with a guanylating reagent.
PROBLEM TO BE SOLVED: To obtain a new compound consisting of a specific xanthine derivative, effective for inhibiting the activity of a transcription factor NFκB and useful e.g. as an agent for the prevention and treatment of diseases to which the NFκB activity inhibiting action is effective, e.g. autoimmune diseases, inflammatory diseases and AIDS. SOLUTION: This compound is a new xanthine derivative (or its salt) expressed by formula I [W is a 5 to 7-membered heterocyclic group containing; N, having oxo group and optionally condensed with an aromatic ring; Y is single bond, a lower alkylene which may have CO group in the chain or on the chain terminal, etc.; L is a lower alkylene; R&lt;1&gt; and R&lt;2&gt; are each H or a lower alkyl; R&lt;3&gt; and R&lt;4&gt; are each H, a lower alkyl, an aryl or a (substituted)lower alkanoyl]. It has an activity-inhibiting action on transcription factor NFκB and is useful e.g. as an agent for the prevention and treatment of autoimmune diseases, inflammatory diseases, viral diseases, etc. The compound can be produced by reacting a compound of formula II or its salt with a xanthine compound expressed by formula III (Q&lt;1&gt; is a reactive residue) or its salt.
PROBLEM TO BE SOLVED: To obtain a safe antidiabetic derived from a natural substance excellent in inhibitory effect on sucrose absorption by using an extract of a specific edible plant as an active ingredient. SOLUTION: This antidiabetic comprises an extract of Momordica cochinchinensis as an active ingredient. Momordica cochinchinensis is widely used for food such as a nutritive tonic in the southern part of China, West and Southeast Asia and its seed is known as Momordica cochinchinensis. Flesh and seed of Momordica cochinchinensis are dried in shade, roughly cut, heated with a solvent such as an alcohol, e.g. methanol or ethanol and water or immersed in the solvent in a cold state to give an extracted solution. The solvent is distilled away from the extracted solution at &lt;=45 deg.C under reduced pressure to give a dried essence, which is used.
The present invention relates to novel connective tissue related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as &#39;connective tissue antigens&#39;, and the use of such connective tissue antigens for detecting disorders of connective tissue(s), particularly the presence of cancer and cancer metastases. More specifically, isolated connective tissue associated nucleic acid molecules are provided encoding novel connective tissue associated polypeptides. Novel connective tissue polypeptides and antibodies that bind to these polypeptides are provided. Also provided are vectors, host cells, and recombinant and synthetic methods for producing human connective tissue associated polynucleotides and/or polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing, treating, preventing and/or prognosing disorders related to connective tissue(s), including cancer, and therapeutic methods for treating such disorders. The invention further relates to screening methods for identifying agonists and antagonsits of polynucleotides and polypeptides of the invention. The present invention further relates to methods and/or compositions for inhibiting the production and function of the polypeptides of the present invention.