anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
The disclosure provides improved methods for treating or preventing a class of undesired health events including multiple related maladies, such as a disease, condition, or syndrome or the like. The improvement results from optimization of energy metabolism by administering a therapeutically effective compound selected to a) modulate mitochondrial activity to correct for deficiencies resulting from the disease, b) to boost cell energy metabolism thereby improving the original method&#39;s efficacy, and/or c) to correct for metabolic disruptions resulting from therapies or medicaments used in the method to be improved. A combination therapy may be designed based on a disease, a group and/or an individual, said combination comprising one or more energy optimization booster combined with a medicament used in an original method is an exemplary embodiment. In some circumstances optimization may involve boosting energy metabolism throughout an organism or in selected cells, tissues or subcellular structures; in some circumstances optimization may involve diminishing energy metabolism throughout an organism or in selected tissues, cells or subcellular structures. In several circumstances diminishing energy metabolism in selected cells to zero or near zero may, by essentially destroying or eliminating mitochondrial functionality of these cells to impair or destroy adverse functionality of these cells or subcellular activity, be optimal for the organism. Biochemicals, including biotherapeutics, may be delivered by any effective method or device, including, but not limited to: injection, oral dosing, nanodelivery, suppository, patches, eye drops, nasal spray, ointment, cream, synthetic gene, conjugated molecule, catheter, timed or controlled release capsule or pill, subdermal implants, diet, etc.
Dental floss brushes, as described herein, are extremely difficult to coat with wax coatings. When conventional waxes are utilized, the floss brush becomes matted and gummy. We have developed an improved wax coating solution which results in a thin, uniform coating with good adhesion characteristics. This invention relates to an improved floss brash product and to a novel process for its manufacture. In particular this invention is directed to an improved floss brash made of a textured, high tenacity nylon yarn which provides the scraping functions of a floss under high tension and the brushing functions of a yarn under low tension. The present yarns require a wax coating to improve lubricity during use. The present product exhibits a uniform, thin wax coating. The present process imparts a thin coating by utilizing a &#34;viscosity lowering agent&#34; in the wax coating solution.
PURPOSE:To provide the title agent, also effective for relieving fatigue due to passive uneasiness, comprising a low-molecular peptide composition obtained by hydrolysis of protein using an enzyme. CONSTITUTION:The objective fatigue-relieving agent comprising a low-molecular peptide composition 200-550 in average molecular weight which can be obtained by hydrolysis at 40-60 deg.C for 18-48hr of protein derived from animals, plants or microorganisms (pref. lactoprotein or soybean protein) using an enzyme (pref. endoprotease active in neutral pH region). This composition consists mainly of dipeptides and tripeptides containing &lt;=20wt.% of peptides with a molecular weight of &gt;=700 and also containing &lt;=5wt.% of free amino acids. The present agent is effective for relieving fatigue due to passive uneasiness as well as active exercise.
In the production of hecogenin, a material of the class of steroidal sapogenins and of possible use in the preparation of hormones, leaves or other material of the plant Agave Sisalana or related plants, e.g. sisal waste obtained after the extraction of the fibre, which may first be defatted by percolation with light petroleum, ether &amp;c., is extracted with hot or cold alcohol, e.g. methyl or ethyl alcohol containing 0-50 per cent. water, a mineral acid is added to the extract to give a concentration of 1-2M, the mixture is refluxed, alcohol is removed, suitably by steam distillation, and an aqueous suspension produced, precipitated solids are separated and saponified by heating with alcoholic caustic alkali, alcohol is removed suitably by steam distillation, and hecogenin is recovered from the aqueous suspension.  Recovery is suitably effected by treating the suspension with an adsorbent such as charcoal, extracting the latter with ether, carbon tetrachloride, trichlorethylene, benzene, ethyl acetate &amp;c. and crystallizing the hecogenin from the solution.  Residual material in the mother liquor is recovered by further fractional crystallization or by chromatography, e.g. on alumina.ALSO:In the production of hecogenin, a material of the class of steroidal sapogenins and of possible use in the preparation of hormones, leaves or other material of the plant Agave Sisalana or related plants, e.g. sisal waste obtained after the extraction of the fibre, which may first be defatted by percolation with light petroleum, ether, &amp;c. is extracted with hot or cold alcohol, e.g. methyl or ethyl alcohol containing 0-50 per cent water, a mineral acid is added to the extract to give a concentration of 1-2M, the mixture is refluxed, alcohol is removed, suitably by steam distillation, and an aqueous suspension produced, precipitated solids are separated and saponified by heating with alcoholic caustic alkali, alcohol is removed suitably by steam distillation, and hecogenin is recovered from the aqueous suspension.  Recovery is suitable effected by treating the suspension with an adsorbent such as charcoal, extracting the latter with ether, carbon tetrachloride, trichlorethylene, benzene, ethyl acetate &amp;c. and crystallizing the hecogenin from the solution.  Residual material in the mother liquor is recovered by further fractional crystallization or by chromatography, e.g. on alumina.
This invention is to be applied to a person&#39;s ear. The Biophotonic Mask Instrument consists of an ear covering component, an ear attachment component, and multiple light emitting units. The Biophotonic Mask Instrument is connected to an external intelligent device with an application to control the operation of the light emitting units. The attachment component is to be clipped onto the body of the ear with the ear covering component connected to it. The multiple light emitting units are arranged to be 0.8mm to 1.2mm apart or 0.65mm to 1.5mm apart. The light emitting units are in a net design and their wave lengths are between 400nm to 1000nm. The Biophotonic Mask Instrument is wirelessly connected to the intelligence device.
A method of determining a pre-disposition of a subject to panic disorder is disclosed based on a modified cellular activity of the amiloride sensitive ion channels (ASICs). Other aspects of the invention relate to compounds for treatment of panic disorder (e.g. psalmotoxins, FMRF-amide and GsMTx4) and for methods of identifying candidate compounds for treatment of panic disorder. An association of amiloride sensitive ion channels and panic disorder is disclosed. More specially, polymorphisms have been identified that associate to a pre-disposition of panic disorder. The discovered polymorphisms are located in the 3&#39;UTR (untranslated region) an ACCN gene, and it is believed that the polymorphisms ultimately affect the cellular activity of the amiloride sensitive ion channel.
Live vaccine against theileriosis in cattle consists of cattle lymphoid cells infested with Schizota of the attenuated strain Theileria annulata KTa No. 7. Pref. the vaccine is administered as a dose contg. 0.1-3 million living, infested clles. The vaccine is prepd. by growing T. annulata CY-1 (isolated from the mite Hyalomma detritum) on cattle lymphoid cells in a nutrient medium for 20-100 days, esp. in 6-12 passages over 60-80 days at 37.5-38.5 degrees C. The schizota are then collected and frozen in presence of a suitable cryoprotectant, esp. glycerine, at is not &gt;-60 degrees C. The vaccine has high immunogenicity and is 10 times cheaper than known vaccines. It is only weakly reactogenic and induces no side effects in vaccinated cattle.
PURPOSE:To develop a synthetic apatite molding suitable as a filling material for the defective part of bones and teeth by discharging an aq. suspension of apatite contg. apatite crystals and binder from a nozzle having a specific size and shape, then spinning and drying the same. CONSTITUTION:5-70% apatite crystal by weight, 5-40% binder such as polyvinyl alcohol and 10-90% water are mixed to prepare a slurry which is then stored in a tank 2. The slurry is supplied through a pipeline 15 to the die which is shaped to 0.1-1.0mm bore and 10-100 ratio of the length/bore. This slurry is extruded from the nozzle 5 under 2.0-10kg/cm&lt;2&gt; extrusion pressure and the air from an air nozzle 7 around the nozzle 5 is simultaneously ejected from a blower 6 at 5-1,000m/sec velocity to form fine fiber flow 8 which is dried 10 by a heating means 9 such as IR heater and thereafter, the coiler 13. The apatite molding in which the apatite crystals are oriented in the C-axis direction is thus obtd.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a portable biomedical information collector which is mountable on human bodies and collects occasional mental conditions efficiently by timely consultation while continuously measuring biomedical information in the daily life.  &lt;P&gt;SOLUTION: The portable biomedical information collector 100 takes out the biomedical information as an electrical signal by a detection circuit 300 and a signal processing circuit 301 and further discretizes it with a conversion circuit 302. A control circuit 303 stores the discretized biomedical information into a memory unit 304 while questions about moods and mental conditions are displayed on a display device 305 periodically and when a substantial change occurs in the biomedical information. Persons each mounting the collector answer to the questions by an input means 307 and the responses are recorded into the same memory unit 304 as in the case of mental information. The biomedical information and the metal information recorded into the memory unit 304 and various set values are written or read out through an external personal computer and a communication circuit 308.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
PURPOSE: To obtain a stable two agent-mixing type cosmetic used by mixing the first agent with the second one just before used, and increasing the viscosity, when the agents are mixed and used. CONSTITUTION: The first agent contains an oxidation dyestuff as a main agent and other components such as an alkali agent, and has a pH of &gt;=5. The second agent contains an oxidizing agent such as hydrogen peroxide and 0.005-5wt.% of a carboxyvinylpolymer, and has a pH of &lt;=5. The first and second agents are mixed with each other so as to give a pH of &gt;=5. The main agent for the cosmetic may be added to one or both of the first agent and the second agent. Since the pH of the second agent is &lt;=5 before the use, the second agent is low in viscosity, does not adhere to the inner wall of the container, and can therefore effectively be used. When the first and second agents are mixed with each other to give the pH of &gt;=5, the viscosity of the mixture increases due to the increased viscosity of the carboxyvinylpolymer.  Thereby, the mixture easily stays at an application point on a human body, and does not limit the freedom of treatments. This two agent-mixing type cosmetic is used for a hair- dyeing agent, a hair-decoloring agent, a permanent wave agent, an epilation agent, etc.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an external preparation useful for treating melanogenesis-related diseases or conditions or skin roughness.  &lt;P&gt;SOLUTION: The external preparation comprises fungi belonging to genus Cordyceps. As the fungi belonging to the genus Cordyceps, Cordyceps sinensis, Cordyceps militaris, and Cordyceps sobolifera can be used. Of them, Cordyceps sobolifera is particularly a suitable example. It is particularly preferred that the fungi belonging to the genus Cordyceps is used as a hot water extract of a fruit body thereof. The hot water extract is incorporated into an external preparation in an amount of 10-1,000 ppm, preferably 25-500 ppm, and more preferably 50-250 ppm.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To provide a skin care preparation hardly providing frigid irritation in use and suitable for the therapy of hemorrhoid. SOLUTION: This skin care preparation for the hemorrhoid contains (1) a medicament and (2) &gt;=70 wt.% glycerol. A local anesthetic, an antiphlogistine, a painkiller, a wound-healing agent, an antioxidant, a hemostatic or the like is preferably cited as the medicament. A nonaqueous gel preparation is preferably exemplified as a dosage form. A polyhydric alcohol such as 1,2-pentanediol and dipropylene glycol is prefarably included therein besides the glycerol. A carboxyvinyl polymer and/or a salt thereof, and a 10-30C alkyl ester of (meth) acrylic acid and/or a salt thereof are preferably exemplified as a gelatinizing agent. An organic amine is preferable as the alkali for the gelatinization.
PURPOSE:To realize rejuvenation and life-prolongation of aged person, by extracting juvenile cell of a man of embryo period, infant or younger generation from every part of the body and injecting or transplanting the cell to the corresponding parts of the parent of the donor of the juvenile cell. CONSTITUTION:Juvenile cells of a man of embryo period, infant or about &lt;=20 years old are extracted from every part of the body. The extracted cells or their cultured cells are injected or transplanted to the corresponding parts of a parent of the donor of the juvenile cell. Prior to the injection or transplantation, half of the blood of the parent is exchanged with that of the child when they have the same blood type or half of the plasma of the parent is exchanged with that of the child when they have different blood type. The rejuvenation and life-prolongation of the parent can be carried out by this process suppressing the rejection reaction. If necessary, an immuno-suppressing agent such as cyclosporin is used in the above treatment. In the case of transplantation to grandfather or grandmother of donor, 3/4 of the plasma are uniformly exchanged among 4 grandfathers and grandmothers on the father&#39;s side and mother&#39;s side and optionally an immuno-suppressing agent is used to suppress the rejection reaction.
The method disclosed herein is applicable in traumatology for treatment of infected false joints, as well as some forms of osteomyelitis. The method consists in administering medicinal solutions to at least two areas in the locus of infection of the bone tissue, one of said solutions Medicinal Solution No. 1 having the following weight percentage composition: -monobasic calcium phosphate 0.0375 to 0.15 -Ca(H2PO4)2.H2O -calcium chloride CaCl2 0.05 to 0.2 -calcium hydroxide 1.5 to 6.0 -novocain 0.09 to 0.36 -sodium chloride 0.216 to 0.864 -antibiotic 1.65 to 6.6 -water to make up 100 percent, -  the pH value of said solution being within 6.0 and 6.4, while administered to the other area of said locus of infection is an antiseptic having the pH value within 7.5 and 8.1, both of said solutions being administered dripwise continuously for 5 to 14 days per treatment course. Applied as an antibiotic is a streptomycin-calcium chloride complex, and as an antiseptic, Saluzid, Solution No. 2. In the most preferable embodiment of the present invention the medicinal solutions are administered to the bone tissue locus of infection through the needles of the Seppo&#39;s construction.
A computerized system and method to allow patient to control and provide a safe, secure and efficient real-time access to the patient&#39;s private health records (PHR) stored in the encrypted uniform format in a Private Health Vault (PHV) database. The system utilizes patient&#39;s private encryption key for encrypting and decrypting PHR stored in the PHV. The patient (or patient&#39;s appointed agent) controls access to the PHR and authorizes by electronic communications with the PHV server to allow doctors to have access to the centrally maintained and structured medical data in the PHV. The access can be limited in duration.The patient&#39;s private keys may be stored in a remote Key Bank database, separately form the PHV database, and the location of the patient&#39;s PHV data may also require transmission of the location id from a separate Mapping server. Additional security is provided by determining digital proximity of the doctor&#39;s and patient&#39;s mobile devices to the node device in the doctor&#39;s office, and terminating access upon set condition. It also utilizes 2-way digital token or id exchange and confirmation between the patent and doctor, as well as digital authentication for access and identity verification. The centralized PHV stores patient data more efficiently and prevents unauthorized use of the patient data by separating the key(s) needed to decrypt patient data from the actual patient records in the PHV.
PURPOSE:To obain a drug effective to promote the restoration of patient, by removing the toxicity of swellfish liver oil having high acidity by a specific method, thereby utilizing the sterilizing activity of the fatty acid of the oil. CONSTITUTION:Raw leaves of a tree (especially cedar leaves) are boiled in water, and the decocted liquid is concentrated with heat. The concentrate is mixed with the liver oil of swellfish. The mixture is boiled for about 30 minutes, left to cool, poured into a glass cylinder, and allowed to separate into two layers. The liver oil mixture is decomposed by boiling producing an egg-yellow coagulate. The egg-yellow top layer is collected, and the pale red lower layer is discarded. The collected top layer liquid is free from glycerol, and nontoxic. A mixture of the liquid with iron powder magnetized to &lt;=1,000 Gauss is useful as an internal drug for tubeculosis, abdominal typhus, etc. or an external drug suitable for varios dermatitis and for sterilization.
The invention discloses a fabrication method of cellulose membrane of a drug loading breast cancer-targeting magnetic nanoparticles. The method includes the following steps: 1. Grant the folic acid of optical activity by chemical modification, fix the prepared acid on the magnetic hydrogel, which then is be used to absorb hematoporphyrin monomethyl and cancer therapeutic drug, and finally obtain the tumor-targeting nano-drug; 2. Produce cellulose membrane by cultivating acetobacter xylinum and static fermentation, add the tumor-targeting nano-drug solution made in step 1 into the container for the cellulose membrane under dark condition until it&#39;s submerged, and carry out vacuum freeze drying after processed by the oscillator. The cellulose membrane of a drug loading tumor-targeting magnetic nanoparticles has high efficient in targeting the breast caner cell and suppressing its growth. At the same time, it can significantly reduce the dosage of conventional photosensitizer. In addition, the transdermal drug delivery would enhance the the drug effects on caner, realizing the controlled-release of the drug and largely lowering the toxic and side effects to healthy tissues.
PURPOSE: To obtain a bathing agent giving a novel use feeling by sustainingly releasing fragrance, and capable of releasing a constant fragrance for a long period of time by containing a fragrance precursor material and an enzyme decomposing the precursor material in a bathing agent. CONSTITUTION: This novel bathing agent contains a fragrance precursor material (suitably a glycoside, a glyceride, a peptide derivative or an amino acid derivative of a fragrance material) and an enzyme decomposing the fragrance precursor material, and sustains the fragrance and has an excellent use feeling. As the glycoside, glucose, galactose, verdure&#39;s alcohol (cis-3-hexenol) or 3-octenol, etc., is exemplified. As the enzyme acting on the glycoside, α-glucosidase, etc., is exemplified. As the glyceride derivative, a monoglyceride between glycerol and a caboxylic acid-based fragrance material, etc., is exemplified. As the enzyme acting on the glyceride, lipase, etc., is exemplified. Besides, an enzyme acting on the amino acid or the peptide derivative, a protease such as a peptidase is exemplified.
PURPOSE: A crude drug composition containing Eucommia ulmoides Oliver and Ledebouriella seseloides WOLFF. is provided to ensure anti-inflammatory and analgesic effects. CONSTITUTION: A crude drug composition for preventing inflammatory bone diseases and nerve regeneration contains 60 parts by weight of Eucommia ulmoides Oliver, 50-60 parts by weight of Ledebouriella seseloides WOLFF., 50-60 parts by weight of Angelica koreana L., 50-60 parts by weight of Cibotium barometz, and 110-120 parts by weight of Paeonia japonica (Makino) Miyabe &amp; Takeda. The composition is prepared by heating a mixture of the ingredients using water, alcohol of 1-5 carbon atoms, or a mixture thereof at 85-105 deg. C. for 2-3 hours. [Reference numerals] (AA) Treated group; (BB) Non-treated group
PROBLEM TO BE SOLVED: To obtain the subject readily applicable and ultralight composition having extreme softness and capable of providing a good state after application and foaming when hydrated by including a binder and a specific powdery filler. SOLUTION: This composition is obtained by including (A) a binder and (B) a powdery filler containing (i) solid particles of a thermoplastic polymer and (ii) a surfactant in a powdery form insoluble in the component A and sufficient to provide a deformable solid appearance. The particle diameter of the component (i) is preferably 1-300 μm, more preferably 10-100 μm. The relative density of the component (i) is preferably &lt;0.09, more preferably &lt;0.04. A (co)polymer of vinylidene chloride, vinyl chloride, acrylonitrile and/or acrylic or styrene monomer is preferred as the material of the component (i). The amount of the component B is preferably up to 80 vol.% of the composition.
BACKGROUND AND PURPOSE: <p>&nbsp; &nbsp; &nbsp; &nbsp; Natural disasters, such as earthquakes, frequently result in mood disorders among affected individuals. It is established that neuropathic pain arising from traumatic neuropathies is also linked to mood disorders. This study investigates the influence of neuropathic pain on the development of mood disorders in earthquake survivors with peripheral nerve injuries, following the earthquake centered in Kahramanmaraş on February 6, 2023. Additionally, we aim to assess the electro&shy;physiological aspects of neuropathic injuries in these survivors.</p>.
METHODS: <p>The study comprised 46 earth-quake survivors with electrophysiologically confirmed peripheral nerve injuries, with 39 trauma-free survivors serving as the control group. Neuropathic pain, anxiety and depression were assessed using the Douleur Neuropathique 4 (DN4) questionnaire and the Hospital Anxiety and Depression Scale (HADS).</p>.
RESULTS: <p>Our findings revealed that the ulnar and peroneal nerves were the most commonly injured structures. Among the survivors with peripheral nerve injury, 31 out of 46 (67%) were found to experience neuropathic pain. Furthermore, plexopathy and multiple extremity injuries were associated with more severe neuropathic pain. However, there was no significant difference in anxiety and depression scores between the two groups and neuropathic pain was found to have no independent effect.</p>.
CONCLUSION: <p>The study indicates that the intensity of neuropathic pain varies based on the localization and distribution of peripheral nerve injuries. However, the presence of peripheral nerve damage or neuropathic pain was not directly associated with HADS scores, suggesting that mood disorders following disasters may have multifactorial causes beyond physical trauma.</p>.