anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
&lt;P&gt;PROBLEM TO BE SOLVED: To enable to intuitively grasp the shape of a stent, and to design a stent model which matches the shape of an anatomical body tubular cavity of each patient while a relation to the peripheral organs is taken under consideration.  &lt;P&gt;SOLUTION: A body axis tomographic image which is formed based on a three- dimensional tomographic image of a patient is displayed on a monitor (S2). Then, selected points are designated on an anatomical body tubular cavity where a stent is made to reside and which is displayed on the body axis tomographic image (S3). Then, a multi-directional reconstructed image (MPR) is displayed on the monitor (S6), and on the MPR, the selected points, an interpolating point which interpolates the selected points, and a central axis L for a stent model which connects respective points are displayed (S8). Then, an operator performs a correction in such a manner that the central axis L may match the center of the anatomical body tubular cavity by moving the central axis L on the MPR (S9). Then, a cylindrical stent model with the central axis L as a center is displayed on the anatomical body tubular cavity (S10), and at the same time, a three-dimensional image is displayed (S11).  &lt;P&gt;COPYRIGHT: (C)2003,JPO
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a composition for reducing a blood urate level and to provide a new use of biotin which has been mainly used in a dermatological field.  &lt;P&gt;SOLUTION: The composition comprises biotin effective for hyperuricemia or diseases (gout, renal disorder, urinary calculus, cardiovascular disturbance, arteriosclerotic disease, metabolic syndrome, etc.) caused by hyperuricemia. The composition comprises biotin for preventing or treating stiffness in the shoulders, neck stiffness, hand and foot numbness, hand and foot chill. The compositions are used for a medicine and/or a food.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
FIELD: medicine, pharmaceutics. ^ SUBSTANCE: invention relates to compositions for intestine cleansing, which include sweetener, representing isomer of chlorinates sucrose and intestine cleanser which includes water, monobasic sodium phosphate and dibasic sodium phosphate. Preferably isomer of chlorinated sucrose is represented by sucralose. Invention also relates to methods of reducing salinity of substance introduced perorally and having perceived salinity, equivalent to amount from 0.2 to 2.6% of sodium chloride in water, by application of sweetener - isomer of chlorinated sucrose. ^ EFFECT: addition of sweetener to salty solution, such as composition for intestine cleansing, provides improved taste attraction to solution and considerably increased patients&#39; readiness to intake it. ^ 25 cl, 2 dwg, 11 tbl, 12 ex
The invention relates to a method and a product for cleaning and/or whitening of teeth. In oral hygiene products, cysteine proteinases have been shown to have a cleaning and whitening action on the teeth. However, tissues suffer damage from an extended action of cysteine proteinases. In this invention, natural human cysteine proteinases are employed for cleaning and whitening purposes and this activity can be blocked by natural cysteine proteinase inhibitors, which are released secondarily from the products at a later stage. In particular, the use of natural cysteine proteinases and their inhibitors provides the advantage that they are man&#39;s own proteins, and therefore the risk of allergization is minimized. In addition, their enzyme kinetics is presently well known.
An absorbent article worn by a wearer adjacent the skin comprises a chassis comprising an outer covering layer comprising a back sheet, liquid pervious top sheet joined to the back sheet and an absorbent core positioned between the back sheet and top sheet. A cuff joined to the chassis has a first surface and a second surface opposite the first surface and contains a skin care composition on the cuff. The composition is a solid or a semisolid at 20[deg]C and is at least partially transferable to a wearer&#39;s skin. The skin care composition preferably comprises: (i) 10-95% emollient having a plastic or fluid consistency at 20[deg]C and (ii) 5-90% of an agent capable of immobilising the emollient on the cuff. The emollient comprises petroleum based emollients, fatty acid ester emollients, polysiloxane emollients, sucrose ester fatty acid emollients, and/or alkyl ethoxylate emollients. The immobilising agent is selected from polyhydroxy fatty acid esters, polyhydroxy fatty acid amides, 14-22C fatty alcohols, 12-22C fatty acids, and/or 12-22C fatty alcohol ethoxylates.
The utility model discloses an oral insulin particle. The utility model uses the traditional Chinese medicine dragon&#39;s blood as a carrier, and uses a micro solid particle of the insulin as a core; the core is embedded in the carrier to form a nanometer insulin microsphere, and the average diameter of the nanometer insulin microspheres is smaller than 80 nanometer. Because the core (the micro solid particle) of the insulin is embedded in the carrier (the traditional Chinese medicine dragon&#39;s blood), when the utility model is taken orally, the core (the micro solid particle of the insulin is not directly contacted with buccal liquifying enzyme or gastrointestinal digestive enzyme, and the activity of the insulin can not be disturbed. After taken, the micro particle of the insulin can be directly absorbed by intestinal villi in intestinal tract, and can join blood circulation. In the process of degradation and absorption, the insulin becomes steady and begins to release slowly, the medicine comprises both western medicine and traditional Chinese medicine, and the utility model is the mixture of the two. The western medicine and the traditional Chinese medicine are matched with each other, and the disease can be completely cured. The utility model is convenient to take, and is an ideal medicine for curing diabetes.
NEW MATERIAL:A compound of formula I [R is 10-16C alkyl which may have a substituent (halogen, OH, carbamoyl, 1-5C alkylamino, 2-6C dialkylamino, 2-6C acylamino, 1-5C alkylthio, SH, 2-6C acyloxy, 6-12C aryl, etc.) or 0-16C alkenyl having one or more vinyl groups]. EXAMPLE:4-Dodecylpyrrole-2-aldehyde. USE:The compound of formula I exhibits an effective triglyceride and choresterol- reducing activity and is useful as hypertension remedy and antiarteriosclerosis drug. PREPARATION:For example, methyl pyrrole-2-carboxylate is reacted with an acyl chloride of formula III (R&lt;1&gt; is alkyl, alkenyl) in the presence of a Lewis acid to prepare the compound of formula IV. The keto group of the compound is reduced and subjected to three steps by Mc Pherdin.Stevens method to provide the compound of formula I.
A mechanism for generating information usable for identifying a risk of arrhythmia. A plurality of heart models are constructed from medical imaging data of a subject&#39;s heart. each heart model being defined by a set of different values for one or more modifiable properties. The modifiable properties are those used in the generation of the heart model or in the definition of the heart model, and influence or affect simulation results using the heart model. Each heart model undergoes a plurality of simulations, each simulation being a simulation of a response of the heart model to a (simulated) stimulation of electricity at a different pacing location of the heart. Output data is generated containing indicators of all simulation results.
A system and method of managing and maintaining electronic health care records on a web based database controlled by the patient where the electronic health care records are updated on the web based database immediately at the point of service. A user patient logs into the system and authorizes health care providers to have access to that user patient&#39;s medical records database. These health care providers generate electronic medical records pertaining to the user patient. These electronic medical records are uploaded onto the user patient&#39;s database and sorted by HL7/FHIR resource code in that database. The electronic medical records are immediately available to the patient and authorized health care providers through the patient&#39;s medical records management system database. Additionally, the electronic medical records of all patients on the medical records management system database are available to be searched as a function of medically relevant data stored on the database.
PURPOSE:To detect a cancer-associated antigen with good sensitivity by crushing cells to liberate the cancer-associated antigen or the antigen in the cells and detecting the liberated antigen. CONSTITUTION:A pancrea structure lump 1 is cleaned with a Hanks soln. and is transferred into a petri disch 2. The lump is then cut to fragments by a surgeon&#39;s knife or scissors. The tissue fragments 3 thereof are transferred into a flask 4 contg. a disperse or trypsine liquid 5 and the liquid is shaken. The enzyme liquid 5 is removed by centrifugal sepn. or filtration, by which the suspension 6 of the cells is obtd. Antigen CEA8a exists on the film surface of the cancer cells 7 and the antigen is produced in the cells as well if the cells are cancerized. An antigen CEA antibody 9 is added to the liquid 6 to induce the antigen antibody reaction with all of the CEA on the film. The antibody 9 is preliminarily labeled by FITC10. The unreacted FITC-anti-CEA antibody is then removed. The cells 7 are crushed by a blender and the antigen is dissolved in a nonionic surface active agent soln. The soln. is passed through a solid phase 12 bound with an anti-rabbit IgG antibody 11 and the fluorescence of the solid phase 12 is measured.
Abstract. The invention provides humanized and chimeric anti-CD20 antibodies for treatment of B-Cell associated diseases such as CD20 positive malignancies and autoimmune diseases, in particular dosage regimen. The present invention is directed to CD-20 antibodies with Fc region substitutions S298A or E333A or K334A or K326A or K326W or K322A, wherein these substitutions improve ADCC or CDC activity of the antibody. Certain aspects of the invention are directed to the use of the CD-20 antibody Rituximab@ (Rituxan@) in the treatment of diseases such as rheumatoid arthritis. The present antibodies are used in treating CD 20 positive cancers such as non-Hodgkin&#39;s lymphoma, treating autoimmune disease and inducing apoptosis in B-Cells. The invention is also directed to combination therapies with further chemotherapeutic agents such as doxorubicin, cyclophosphamide, prednisolone or CHOP, with further anti-rheumatic agents or with further immunosuppressive agents such as methotrexate. The invention also encompasses methods of producing CD-20 antibodies using vectors and host cells comprising nucleotide sequences encoding the CD-20 antibodies.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a food and drink composition which can be suitably used for comparatively mildly and effectively inhibiting weight gain, bone density decrease and the like in climacteric women.  &lt;P&gt;SOLUTION: The food and drink composition includes a fermented soybean embryo extract and an Acanthopanax senticosus Harms root extract. A food and drink composition for inhibiting weight gain in climacteric women and a food and drink composition for inhibiting bone density decrease in climacteric women comprises the food and drink composition. The fermented soybean embryo extract is an extract from a substance obtained by hydrolyzing a protein and an isoflavone glycoside which are contained in a substance produced by koji-making treatment of a soybean embryo, and contains 30 wt.% of an isoflavone aglycone. The Acanthopanax senticosus Harms root extract is extracted from an Acanthopanax senticosus Harms root part with hot water and ethanol.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To enable to transmit the living body information to the outside apparatus to store without awareness of a user.  &lt;P&gt;SOLUTION: A measuring means 101 measures the living body information of a living body. A first memorization means 103 memorizes the living body information. A detecting means 107 detects whether the living body contacts a living body information controlling device or not. A transmitting means 104 transmits the living body information to the living body information controlling device through the living body when the living body is detected to contact the living body information controlling device. A suspension means 102 suspends to transmit the living body information when the living body is detected not to contact the living body information controlling device. A second memorization means 108 memorizes a data suspension position of the suspended living body information. A living body information measuring device 13 is equipped with the above composition. The living body information controlling device 23 is equipped with a reception means 204 which receives the living body information from the living body information measuring device through the living body and a third memorization means 203 which memorizes the received living body information.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
The invention belongs to the fields of biology and medicine, and relates to a novel alpha-conotoxin peptide TxIE, a pharmaceutical composition thereof and application thereof. Specifically, the invention relates to an isolated polypeptide, which is a polypeptide with an amino acid sequence shown as SEQ ID NO. 1 or a mutant thereof; wherein the amino acid sequence of the mutant is that the 1 st glycine in the sequence shown by SEQ ID NO. 1 is replaced by glutamic acid or aspartic acid; and/or the methionine at position 15 in the sequence shown in SEQ ID NO. 1 is replaced by alanine, leucine or isoleucine. The polypeptide of the invention can specifically block acetylcholine receptors, particularly has high selectivity and strong blocking activity on drug target points alpha 6/alpha 3 beta 2 beta 3nAChR of addiction and Parkinson&#39;s disease and drug target points alpha 6/alpha 3 beta 4nAChR related to pain, and has the potential of preparing drugs for smoking cessation, drug rehabilitation or pain relief, or preparing drugs for preventing and/or treating Parkinson&#39;s disease, depression, dementia and schizophrenia.
A herbal composition and process for preparing a detoxifying herbal extract using the stem bark of the woody liana, Dalbergia horrida for treatment of snake bite specifically Cobra (Naja naja) and Russell&#39;s viper (Daboia russelli) in mammalians. The herbal composition can also be used to treat venomous bites of krait, bugarus caeruleus, Saw scaled viper, Echis carinatus, Monocelled cobra, Naja kaouthia and King cobra, Oohiophagus hannah. An extract (Dalbergia horrida) can be performed utilizing an ethanol solvent. Further, the extract can be performed utilizing a methanol solvent (an alcoholic solvent) separately. The ethanol extraction and methanol extraction of the herb can be performed using a common plant extraction approach (CPEA). The concentrated ethanol and methanol solvents can be pooled together in order to obtain a novel detoxifying herbal extract for treatment of snakebite.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a cosmetic mask which is hardly peeled off during it is used.  &lt;P&gt;SOLUTION: In the cosmetic mask, a mask body 1 and ear hanging parts 2 are connected. The ear hanging parts 2 are provided on the right and left of the mask body 1. By blanking a sheet of unwoven fabric, the mask body 1 and the ear hanging parts 2 of the same body are formed to obtain the cosmetic mask. Further, it is also possible to obtain the cosmetic mask by softening or melting the end edges of a mask body 1 made of the unwoven fabric and ear hanging parts 2 made of the unwoven fabrics separate from each other to connect the mask body 1 and the ear hanging parts 2 by fusion joint. On one surface of the mask body 1, a chemical layer 3 is applied. Then, the mask is used by sticking the mask body 1 to the lower part of the chin so as to make the chemical layer 3 abut on the lower part of the chin at the face surface, and engaging the right and left ear hanging parts 2 with the right and left ears, respectively. In this case, when the right and left ear hanging parts 2 are stretched and stuck to the lower part of the chin, extending stress works to the mask body 1 made of the unwoven fabric, and the mask body 1 is closely fitted to the lower part of the chin in the state of lifting the slack at the lower part of the chin.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
A biodegradable material for improving the regeneration of nerve cells is disclosed. The material includes a copolymer formed by reacting a first reactant selected from monomers, oligomers and polymers and a second charged reactant selected from charged monomers, charged oligomers and charged polymers. Nerve cells are contained within or attracted to the copolymer. The first reactant can be oligo(poly( ethylene glycol) fumarate). The charged reactant can be selected from unsaturated quaternary ammonium compounds. The material can include a photoinitiator such that the material is photocrosslinkable. The material can include a bioactive agent such as a nerve growth factor. In one form, the material is a hydrogel that can be injected as a fluid into a patient&#39;s body via minimally invasive arthroscopic techniques to form a scaffold for nerve tissue regeneration.
A computer-assisted and automatic identification of possible cranial positions for any kind of implant is presented. In this method, skull data of the individual patient&#39;s skull are used as well as statistical skull data which include so-called skull avoidance zones. Further, a digital template of the implant is used to find these possible positions. The implant may be e.g. an IPG and/or the screws of a fixation frame, but these are only embodiments of implants and other implants may be used with the present invention as well. The computer-implemented medical method of the present invention removes the uncertainty whether a given patient can safely receive an implant, like for example a cranial IPG, which was previously only possible on the basis of human judgement. Furthermore, the present invention removes the uncertainty whether a given patient can be safely fixated in a stereotactic frame or a Mayfield head clamp. The present invention supports the localization of optimal implant location as well as neuro-navigation guided execution of surgery. This enhances safety and speed of the entire medical procedure, as will be explained in more detail hereinafter. The advantages described hereinbefore are in the same way realized by the computer program, the medical system and the navigation system for computer-assisted surgery of the present invention.
FIELD: veterinary science and medicine. SUBSTANCE: invention relates to development of disinfectant agent - &#34;Theotropin&#34; of the formula (C 18 H 16 N 4 ). Preparation shows virulicide and Bactericidal effect, low toxicity level and chemical aggressivity. Disinfection is carried out with 0.1-5% aqueous solutions of preparation by methods of spraying or as an aerosol. Preparation does not exhibit toxic effect on animals and birds. It can be synthesized from the home raw and retains its disinfecting properties in aqueous solution for 120 days, not less. Preparation is used for disinfection of equipment, tools, devices and so on from pathogenic viruses. EFFECT: enhanced effectiveness of preparation. 4 tbl
NEW MATERIAL:A compound of formulaI(X is H, lower alkoxyl or lower alkyl; R&lt;1&gt; and R&lt;2&gt; are lower alkyl) and an acid addition salt thereof. EXAMPLE:4-Benzylidene-2- 4-(2-dimethylaminoethoxycarbonyl)phenyl -1, 3-oxathiolan-5-one. USE:A hypotensive agent. PROCESS:A novel acid halide of formula II(Y is halogen) is reacted with an alcohol of formula III to give an ester derivative of formulaI. The reaction is preferably carried out in a solvent, e.g. tetrahydrofuran (THF) or chloroform, advantageously by using the compound of formula III in an amount about equimolar with the compound of formula II at -20 deg.C-about the boiling point of the solvent.
PURPOSE:To separate the components of blood efficiently, by making the boold flow continuously at a suitable rising angle in the flow direction thereof, and transferring the blood stream to a multilayered stream consisting of the component layers. CONSTITUTION:Blood is separated into the components thereof by the settling action of the gravity.. In the process, the blood is made to flow through a blood path 2 at a rising angle &gt;=10 degrees and &lt;=45 degrees in the flow direction of the blood. The depth of the blood stream is 0.2-20mm., preferably 0.2-10mm. and the linear velocity of the blood stream is 0.5-200mm./min, preferably 1-100mm./ min. The blood stream is desirably kept at 30-42 deg.C,preferably 37-40 deg.C. The blood under the conditions described above is made to flow from a blood introductory path 3 to give the desired components of the blood from discharge paths 6 and 7 for separated components. The material of a closed vessel is required to be a hard nontoxic and antithrombotic material without changing by the internal pressure, e.g. polycarbonate resin.
PROBLEM TO BE SOLVED: To obtain a composition especially usable in a cosmetic and/or a demographic field, locally applicable to a face including the periphery of an eye, a body and a scalp. SOLUTION: This composition contains ascorbic acid and a polyol. The composition contains 0.05-10wt.% of ascorbic acid and 30-99.99wt.% of a polyol so as to make the water activity value of the composition &lt;=0.85, preferably &lt;=0.7 in order to avoid deterioration of ascorbic acid. The composition further comprises at least one selected from among a polymer and an oil. the polyol is selected from among glycerol and a glycol. The polymer is selected from among an acrylic polymer and a methacrylic polymer and further contains bound water. The composition has 70-99.99wt.% content of the polymer, the polyol and the bound water and 5-60wt.% content of the oil and is prepared in the form a gel or an emulsion.
The present invention provides a hemostatic material which is excellent in hemostatic property, biodegradability and bioabsorbability, uniformity and stability of the quality, as well as reduces a risk of contamination with a pathogenic organism derived from an animal. The hemostatic material comprises a thrombin and a synthetic polypeptide capable of forming a triple helical structure. The polypeptide may show a peak of the molecular weight in the range from 5x10&lt;SUP&gt;4 &lt;/SUP&gt;to 100x10&lt;SUP&gt;4 &lt;/SUP&gt;in the molecular weight distribution. The polypeptide may contain at least a peptide unit represented by the formula: -Pro-X-Gly- (in the formula, X represents Pro or Hyp). The thrombin may be a recombinant. In the hemostatic material, the proportion of the thrombin may be about 0.1 to 500 units (U) relative to 1 mg of the polypeptide. The hemostatic material may further comprise a binder component having biodegradability and bioabsorbability. The hemostatic material may be formed on a substrate.
The present invention relates to a composition for preventing or treating vascular disease, containing a Parthenocissus tricuspidata (Siebold &amp; Zucc.) Planch. extract or a compound isolated therefrom. The Parthenocissus tricuspidata (Siebold &amp; Zucc.) Planch. extract or the compound isolated therefrom can be useful for a composition for preventing or treating vascular disease owing to excellent thrombin inhibiting activity.