anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
FIELD: veterinary biology and immunology. SUBSTANCE: the present innovation deals with manufacturing and application of biological preparations for vaccination in animals. The suggested vaccine includes protective antigen of vaccine strain 55 VNIIVV&amp;M at concentration of 17,5±2,5 immunizing doses and alive spores of vaccine strain STI-1 at concentration of 2,5±0,3•10 7 /ml physiological solution. This vaccine is safe and provides tense antitoxic and antimicrobial immunity against anthrax. This innovation could be applied for specific prophylaxis of anthrax in animals. EFFECT: higher efficiency. 6 tbl
FIELD: biotechnology; microbiology.SUBSTANCE: group of inventions relates to biotechnology and medical microbiology and includes three objects: a method for producing a set of fluorescent rickettsial and query fever diagnosticums, use thereof for serological diagnostics of rickettsiosis and query fever, a method for serological diagnostics of rickettsiosis and query fever. Method for producing a set of fluorescent diagnosticums of rickettsiae of group of typhus (R.prowazekii, R. typhi), rickettsiae of groups of spotted fever (R.sibirica, R.conorii) and genus Coxiella (Coxiella burnetii) includes preparation of sorbent from formalized lactic acid bacilli with their labeling with inorganic fluorophores, extraction of active protein-lipopolysaccharide complex from corpuscular antigens Rickettsia prowazekii, R. typhi, R.sibirica, R.conorii, Coxiella burnetii combined methods of ultrasonic disintegration of corpuscles and chromatography, attachment of a protein-lipopolysaccharide complex to a fluorescent sorbent by means of a binding reagent and obtaining an end product – set of fluorescent rickettsial and query fever diagnosticums. Kit contains 5 lyophilically dried diagnosticums: fluorescent diagnosticum R.prowazekii, fluorescent diagnosticum R. typhi, fluorescent diagnosticum R.sibirica, fluorescent diagnosticum R.conorii, fluorescent diagnosticum C.burnetii. Obtained fluorescent diagnosticums are correlated by specificity and sensitivity with a reference preparation – &#34;gold standard&#34; of immunofluorescence – (indirect immunofluorescence reaction, IIFR) and are suitable for diagnosing said diseases. Method for serodiagnosis of rickettsiosis and query fever using a kit is carried out in the format of a single-step direct immunofluorescence method involving applying a test serum onto a slide, adding a fluorescent diagnosticum and incubating mixture at 37 °C for 60 minutes. Smear preparations are dried and viewed under the immersion lens of the fluorescent microscope, the results are evaluated by a four-cross system, documentation is carried out by preserving object glass with smears or preservation of photo from microscope on USB-carrier.EFFECT: proposed group of inventions enables accurate and effective serological diagnosis of rickettsiosis and query fever.9 cl, 10 dwg, 2 tbl, 9 ex
A two sided digital platform for medical patients and medical providers is described in this document. On the provider side, users are able to create digital healthcare assets and programs which prescribe a set of instructions to patients. These instructions may vary from a detailed long-term medical care-plan to a quick survey of questions to be filled. From the patient side, users may browse medical programs which are made open by providers, as well as be assigned personalized programs by their caregivers. Feedback is given to the system by both providers and patients, which feeds a recommendation mechanism that suggests patients relevant programs that may help them achieve healthcare and lifestyle goals. Users are able to view their programs in a compartmentalized view, whether it is providers editing their programs under both public and private settings or patients reviewing all of the programs they are enrolled in and assigned divided based on the programs&#39; inherent instructions. Patients&#39; adherence to programs is constantly reviewed, and intelligent notifications and motivations are presented to patients to ensure constant improvement and optimal progress.
3:4 - Dihydro - 1:2:4 - benzothiadiazine - 1:1 - dioxides of the formula: &lt;FORM:0946864/C2/1&gt; in which R1 is halogen, e.g. Cl or Br, or CF3, R2 is hydrogen or a C1-6 aliphatic hydrocarbon radical, a C3-6 monocyclic aliphatic hydrocarbon, e.g. cycloalkyl or cycloalkenyl, radical, an alkyl group substituted by a C3-6 monocyclic aliphatic hydrocarbon radical or a phenyl, phenylalkyl or phenylalkyl radical, all of which radicals may optionally bear halogen, nitro or esterified or etherified hydroxy or mercapto substituents, R3 and R4 are hydrogen or alkyl, phenyl, phenylalkyl or C3-6 monocyclic aliphatic hydrocarbon groups or alkyl groups substituted by a C3-6 monocyclic aliphatic hydrocarbon group, or R3 and R4 form with the N-atom of the sulphamoyl group a heterocyclic ring such as piperidine, pyrrolidine or morpholine and R5 is a hydrogen atom or a C1-6 alkyl or alkenyl group, are prepared by treating a disulphide of the formula: &lt;FORM:0946864/C2/2&gt; wherein X is an amino group and Y is a substituted or unsubstituted sulphamyl group or X and Y together with the two carbon atoms of the benzene ring form a dihydrothiadiazine ring (optionally bearing substituents R2 and R5), with oxidising and sulphonyl halide forming agents, e.g. (a) with hydrogen peroxide to give a sulphinic acid which is then treated with an aqueous solution of a halogen, (b) with an excess of hydrogen peroxide to give a suplhonic acid which is halogenated with an inorganic acid halide, or (c) in one step by treating the compound of formula II with chlorine; treating the 2 - sulphamoyl-aniline - 4 - sulphonyl halide if formed i.e. in the case where X is amino and Y is sulphamoyl with an aldehyde R2CHO to effect cyclization and condensing the resulting 3,4 - dihydrobenzo -thiadiazine - 7 - sulphonyl halide with ammonia or an amine R3-NH-R4.  Bis - (6 - R1 - 3,4 - dihydro - 1,2,4 - benzothiadiazine - 1,1 - dioxide-7) - disulphides corresponding to the formula II wherein X and Y form a dihydrothiadiazine ring, are prepared by treating a 5 - R1 - 2 - sulphamyl - aniline with thiocyanogen in acetic acid, treating the resulting 4-thiocyanate with ammonia to give a bis-(2-R1-4-amino-5-sulphamyl - phenyl) - disulphide and condensing with an aldehyde R2CHO.  Cyclopentyl - acetaldehyde - dimethylacetal is made by reaction of methylorthoformate with cyclopentylmethyl magnesium bromide.  Specifications 847,064, 861,367 and 863,474 are referred to.
An exemplary nasal inhaler band is fitted on the upper lip below the nasal openings of a user. The device provides minimal restriction of ambient airflow into the nostrils during inhalation, while also providing a flow of beneficial vapors into such airflow. A main body of the device has an outer layer adapted to hold vapor-releasing solids, liquids or gels. The outer layer is air-permeable and absorbent. The main body also has a base layer contacting the upper lip. The base layer is impermeable, so that volatile solids, liquids or gels do not come into contact with the user&#39;s skin. The main body is held in position in contact with the nose and upper lip by elastic straps extending back from ends of the main body to wrap around the user&#39;s ears.
PURPOSE:To provide a cosmetic composition containing the oil of Hippophac rhamnoides. L, etc., having a reduced content of tocopherol, not coloring with time and therefore having a high commercial value, the oil of the Hippophac rhammoides. L being prepared by dissolving the oil of the Hippophac rhamnoides. L or a hydrogenated product thereof in a non-polar solvent and subsequently passing the prepared solution through an adsorbing tower. CONSTITUTION:An oil obtained from the pericarp of Hippophac rhamnoides. L or a hydrogenated product thereof is dissolved in a non-polar solvent (e.g., petroleum ether, n-hexane or CCl4) and once or circulatively passed through an adsorbing tower filled with an adsorbing agent (e.g., silica or active China clay) to give the purified oil or the hydrogenated product thereof wherein the content of tocopherol is reduced to &lt;=200ppm. An cosmetic composition contains the purified oil or the hydrogenated product thereof. The solvent after treated is distilled off by a heating distillation process only or together with a steam- bubbling process under a reduced pressure. The cosmetic composition has excellent storage stability because of generating no coloration caused by the oxidation reaction of the tocopherol.
A condition visualization system includes a first acquisition unit, an estimation unit, a processing unit, an output unit, a second acquisition unit, and a correction information generation unit. The first acquisition unit acquires a user&#39;s biometric information. The estimation unit obtains, based on the biometric information, an estimated value representing the user&#39;s mental and physical condition. The processing unit generates, based on the estimated value, mental and physical condition information. The output unit outputs the mental and physical condition information to a display unit. The second acquisition unit acquires a subjective value with respect to the user&#39;s mental and physical condition. The correction information generation unit generates correction information by using a plurality of data sets, each including the estimated value and the subjective value. The processing unit generates the mental and physical condition information by making correction to the estimated value based on the correction information.
FIELD: medicine; surgery; urology; dermatology; stomatology; otolaryngology; gynecology; proctology; physiotherapy. SUBSTANCE: biologically active composition is turned out in form of balm and contains aqueous extracts from plants, namely: cudweed herb, yarrow, celandine, thyme, wild majoram and St.John&#39;s-wort; mint leaves; pine-tree buds; pot-marigold and matricary flowers; fruits and/or leaves of horse chestnut; liquorice root; essential oils selected from the group consisting of peppermint oil, coriander oil, anise oil, fir-tree oil and camphorated oil; aqueous ammoniacal solution; glycerol; oleic acid and distilled water. Essential oils are used as flavoring and oleic acid - as cosmetic agents, and distilled water - as extract. Flavoring component is used in combination with tonic additives in amount of not more than 0.2% based on total weight of composition base. Components may be taken in various combinations and in various weight ratios. Also proposed is method for producing composition. EFFECT: broadened range of therapeutic action. 3 cl
PURPOSE: To obtain a cosmetic composition useful as a cleaning mask and further capable of modifying gloss of the face by compounding polyamide particles which are dispersed in an aqueous gel as an essential cleaning agent and have roughly spherical shapes of specific sizes. CONSTITUTION: This cosmetic composition is obtained by compounding an aqueous gel with polyamide particles which are dispersed in the aqueous gel and have roughly spherical shapes of specific sizes, wherein the particles are contained in an amount of &gt;=12 wt.% (especially, 12-35 wt.%) of the total amount. It is preferable that the particles have densities of 1.0-1.84 g/cm&lt;3&gt; , especially 1.02-1.4 g/cm&lt;3&gt; and sizes of 5-50 μm, especially 10-30 μm. Regarding the gel, the gel contains at least one or more kinds of gelling agents in a water-soluble vehicle, and the gelling agent is preferably selected from a water-soluble polymer and a polymer which can give a colloidal solution in water. As the gelling agent, an acrylic polymer, a methacrylic polymer, a carboxyvinylpolymer, etc., is suitable. The composition can be removed simply by washing and rising.  Further, the composition can exhibit visual effect for reducing the depths of wrinkles.
PURPOSE: To obtain a cosmetic composed of an aromatic ring-containing polyol or a heterocyclic ring-containing polyol having a specific composition, having good balance of water resistance and oil resistance and excellent in persistency of make up effect and brightness of color and tough feeling. CONSTITUTION: This cosmetic contains 3-80wt.% of (A) a polyhydric alcohol ester of an aromatic polycarboxylic acid and/or (B) an alkylene oxide adduct of a heterocylic ring-containing acidic substance as active ingredient. The component A is obtained by subjecting 1 equivalent of an aromatic dicarboxylic acid (e.g. isophthalic acid) to esterification reaction with &gt;=2 equivalent ratio (OH/ carboxyl) of a polyhydric alcohol (e.g. ethylene glycol). The component B is obtained by adding about 3mol of alkylene oxide to 1 equivant of a heterocyclic ring-containing acidic substance (e.g. isocyanuric acid). The polyol having a specific composition has good solubility and dispersibility and especially effective in preparing make up cosmetic such as lipstick or foundation.
The invention comprises compounds of formula &lt;FORM:1016526/C2/1&gt; wherein R1 is lower (i.e. 1-7 C) alkyl, R2 is halogen, R3 is halogen, R4 is lower alkyl or phenyl optionally substituted by lower alkyl groups, and the broken lines denote optional substituents and their preparation by cyclizing compounds of formula &lt;FORM:1016526/C2/2&gt; wherein X is halogen, by treatment with N,N-dimethyl-formamide. Anthranilic acid derivatives II are preparable from the appropriate N-R4-anthranilic acids and haloalkanoyl halides. Pharmaceutical compositions comprise compounds I and carriers. Tablets, capsules, dragees, suppositories, solutions, suspensions and emulsions are mentioned for enteral and parenteral administration. The compounds are diuretics and choleretics.
PURPOSE: To provide a enteral nutrient prepn. of high protein, low fat and high calorie having advantages of maintaining the gastrointestinal tracts of an HIV infected person at a normal level and prohibiting the worsening of his immune systems. CONSTITUTION: This nutrient pharmaceutical prepn. for enteral nutrition supplementation for the HIV infected person consists of (A) a first protein source consisting of the soybean protein hydrolysis product(SPH) of which 30 to 60% of the particles have a mol.wt. distribution of 1500 to 5000 dalton measured by a steric exclusion chromatography and more preferably the SPH having a hydrolysis rate is preferably 14 to 17 and &lt;1% in the free amino acid in the amino acid compsn., (B) a second protein source consisting of the flawless (nondecomposed) protein (e.g.; sodium caseinate, whey protein separated matter) of the amt. sufficient for stable emulsification of the SPH and this flawless protein and (C) a fat source (e.g.; fish oil, canola oil) of 1.3:1 to 2.5:1 in the weight ratio of the total sum of n-3 fatty acid to the total sum of n-6 fatty acid.  Dietary fiber sources (e.g.; soybean protein) are further compounded with this prepn.
The present invention provides a method of treating or preventing a disease in a subject, which disease is a liver injury induced by acetaminophen, comprising the step 5 of: administering an effective amount of a composition comprising at least 15% by weight of flavonoids obtained from leaves of at least one species of Vaccinium (V.) based on the weight of the composition to the subject. Fig. 1A Fig. 1B Lig. 1 &amp;4 Fig 1 D Fig. IC Fig. ID
The present disclosure belongs to the field of health care products, disclosing a powder having effect on enhancing immunity, method for preparing the same and use thereof. The powder is made from synanthrin, Lycii Fructus, Poria, Lentinus edodes (Berk.) Sing, Mori Fructus, Chrysanthemi Flos, Codonopsis Radix, Flammulina velutipes, Hericium erinaceus and Tremella Fuciformis. The raw materials of the powder are all from natural Chinese herbal medicine without addition of excipient. It is clean and has natural components, in line with people&#39;s pursuit of natural and health foods. In addition, dosage required for the powder is small; it is easy to be taken and can be dissolved in water; it is soluble in cold water and can be absorbed quickly. The method for preparing the powder in the present disclosure is simple and suitable for large-scale production. Also, it is easy to be carried. The powder obtained has a good stability, long storage time, good taste. It melts in mouth and is soluble in cold water. Experiments show that the powder of the present disclosure can significantly enhance immunity, therefore can be used to prepare the health care foods having function on improving immunity.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a porous polymer particle having excellent touch feeling and high oil absorption; to provide a method for producing the porous polymer particle, a gel-shaped composition and a cosmetic containing the particle.  &lt;P&gt;SOLUTION: The porous polymer particle is obtained by allowing (A) 60-100 mass% monomer in the whole monomers to have &lt;8.8 solubility parameter, and (B) 0.02-15 pts. by mass of a crosslinking agent based on 100 pts. by mass of the whole monomers to be present in a W/O/W type emulsion, and polymerizing the monomers. The method for producing the porous polymer particle, the gel-shaped composition containing an oily component and the porous polymer particle, and the cosmetic containing the porous polymer particle are also provided.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to dentistry. The study is carried out 3 times in different visits with a frequency of once a week for three weeks. The study is carried out in the morning on an empty stomach, without preliminary brushing the teeth, smoking, rinsing the mouth with water. Stimulation of salivation is carried out 30 minutes before the study. The patient takes 8 drops of a 1% solution of pilocarpine hydrochloride orally. After 30 minutes, the mucous membrane of the lower lip is removed, isolated and dried with sterile gauze wipes. A sterile 2 x 2 cm frame made of nickel-titanium wire 1 mm in diameter is applied to the mucous membrane of the lower lip. A 2% solution of methylene blue is applied with a sterile cotton ball and the mucous membrane of the lower lip, bounded by a frame, is stained to the inner borders of the frame. The frame is removed. After 20 minutes, photographs are taken with a digital camera with a macro function. The digital image counts the number of drops of saliva secreted by the small salivary glands (SSG) within the colored mucosa. The average individual number of functioning SSG is calculated.EFFECT: method provides objectivity and accuracy of xerostomia diagnosis, increases information content of examination, makes it possible to store research results on electronic media, in patient&#39;s electronic medical record, allows tracking changes in the number of functioning small salivary glands in dynamics during therapy, using examination data in retrospective studies.1 cl, 5 dwg, 2 ex
&lt;P&gt;PROBLEM TO BE SOLVED: To effectively use electronic information representing handwriting-input medical information.  &lt;P&gt;SOLUTION: In a system 200 for medical information management, an electronic pen 12 acquires medical information data input to a form 10 by handwriting. A figure area specification part 62 specifies a figure area defined by a figure that figure data included in the medical information data, based upon the acquired medical information data. A comment area specification part 64 specifies a comment area at a specified position in the specified figure area. A comment data specification part 70 specifies comment data inputted into the comment area by handwritten in the acquired medical information data. A storage part 44 relates and stores the acquired medical information data and specified comment data.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
An integrated on-line and off-line interrogation system includes a physician-seeking system, an on-line interrogation system, a banking card transaction management system, an electronic health record management system, a (on-line) physician module, and a (off-line, in-hospital) physician module. The physician-seeking system allows patients to search for physicians. Patients can select on-line real-time interrogation and appointment, or select off-line interrogation and add-on or registration, or be referred to off-line interrogation from on-line referral. Patients&#39; image data and health records of off-line interrogation can be classified and managed using the electronic health record management system, thereby achieving convenient and paperless operation. Pairing (on-line) physicians and (off-line, in-hospital) physicians provides a basis for localization management of physicians and facilitates on-line and off-line referral. This system establishes a real-time, convenient interrogation channel between patients and physicians without spacial and temporal limitation, thereby maximizing possibility of interrogation and solving difficulty in physician seeking and queuing.
795,870. Surgical dressings. JOHNSON &amp; JOHNSON. July 26, 1956 [April 29, 1955], No. 12408/55. Addition to 640,541. Class 81 (2). A surgical dressing incorporates an X-ray opaque member, other than a filament, which comprises a non-tacky flexible resin or elastomer combined with X-ray opaque material. A gauze pad A is folded and stitched to form a pocket in which an X-ray opaque member E is inserted. The member E is an annulus of oval or rectangular cross-section or may be a narrow strip of square cross-section or in the form of a square or disc. The member E is made of polyisobutylene or vinyl acetate vinyl chloride polymer and includes 40-90 per cent by weight of X-ray opaque material. The X-ray opaque material is an element or derivative of an element having an atomic weight greater than 100, e.g. barium sulphate. Specification 716,923 is referred to.
The invention discloses a preparation method of hydrogel capable of loading various molecules and used for healing infected wounds. The invention prepares the poly (acrylamide-co-acrylic acid) hydrogel (PAM-AA) by simple one-pot method thermal initiation. Acrylamide (AM) and Acrylic Acid (AA) are used as raw materials, ammonium persulfate/tetramethylethylenediamine (APS/TEMED) is used as an initiating system, N&#39; -Methylene Bisacrylamide (MBA) is used as a cross-linking agent, and PAM-AA is formed by initiating polymerization under the heating condition. The polymerization reaction conditions are optimized, and the hydrogel with the lowest monomer residual rate is obtained. The prepared hydrogel can load and release various molecules through hydrogen bonds and electrostatic interaction. The doxycycline-loaded hydrogel has good in-vitro and in-vivo antibacterial activity on gram-positive bacteria and gram-negative bacteria. In a rat full-thickness skin defect wound model infected by methicillin-resistant staphylococcus aureus, the doxycycline-loaded hydrogel shows a good treatment effect and can remarkably promote wound healing. The invention has simple process flow, low production cost and good biological safety, and is expected to play a role in the field of medical antibacterial dressings.
A fluid sampling device and a method is provided for collecting body fluid samples such as blood without the intervention of medically trained personnel. The body fluid sampling device having a sample containment chamber made of a material having a thermal inertia permitting the maintenance of sample temperature over a known period of time. Optionally an isolating cover or sleeve may slide in place by a mechanism triggered by thermal contraction of an element after the device has reached a sufficiently low temperature in a patients refrigerator. Associated methods are provided to ensure hermetic transport of the collected body fluid sample to an analysis lab. Also disclosed is a device and app combination for drug or vaccine injection, the app including means to allow for verification of the patient&#39;s ID and/or the particular device used. The device my be equipped with geo-localization and long-range communication capabilities.