anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a medicinal composition containing an arachidonic acid- containing fatty oil or fat as an essential ingredient and capable of practically and effectively preventing and treating liver diseases such as liver cancer. SOLUTION: This medicinal composition for preventing and treating liver cancer contains an arachidonic acid-containing fatty oil or fat as an essential ingredient. The medicinal composition preferably further contains a docosahexaenoic acid-containing fatty oil or fat and an oyster flesh extract. The content of the docosahexaenoic acid is preferably 0.5-10 times that of the arachidonic acid. The medicinal composition is preferably prepared in the form of soft capsules or tablets. The medicinal composition is administered to an adult so that the daily intake of the arachidonic acid is preferably 400-1,000 mg/day, while the medicinal composition is preferably administered to a mammalian except to the man so that the daily intake of the arachidonic acid is preferably 5-10 mg/kg.  The arachidonic acid-containing fatty oil or fat is added so that the content of the arachidonic acid is preferably &gt;=10 wt.% based on the medicinal composition.
Hair dye composition and method of dyeing hair that targets only at least one grey part using a permanent hair dye component comprising a specific volume percentage of a particulate pigment to permanent hair dye component. The purpose of some embodiments of the invention is to delay the need for women to dye their hair in full. At least one pigment particle (about 0.0770 ml or about I/64th of a teaspoon) may be added to a bottle of 71 ml of permanent hair dye, which allows the permanent hair dye composition to become visible and allows for more accuracy during application. Using small quantities of 5 cc per application (hair dye: 2.5 ml; developer: 2.5 ml reduces the amount of dye applied to needless areas of the hair. The use of a make-up sponge stick allows for better accuracy. The composition is multi-use, and provides for 28 applications (71 ml bottle of dye and 71 ml of developer), and will save users time and money. All these characteristics provide for a hair dye composition that significantly reduces the amount of harmful chemicals applied to users&#39; hair.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a cosmetic good in feeling in use as a foam cosmetic or pack cosmetic.  &lt;P&gt;SOLUTION: The foaming cosmetic contains (1) xanthan gum and (2) quince seed extract. As a formulation of this cosmetic, an aerosol cosmetic extruding foam together with gas is preferable. This cosmetic is preferably a pack cosmetic. Owing to a combination of the above two ingredients(1) and (2), this cosmetic gives foam of high firm texture and stability, and such foam properties improve feeling in use of the cosmetic.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
FIELD: cosmetic compositions. SUBSTANCE: balsam contains complex of biologically active substances of vegetable and/or animal origin, citric acid, glycerine, flavor and water, polyethylene oxide gel, yolks of hen&#39;s eggs and sodium benzoate. As flavor may be used chocolate, mango and pear essence. Complex of biologically active substances may contain propolis extract, honey and cocoa, birch leaf extract, oat straw decoction, sweetflag root extract, nettle extract, millet, pine and mint oils. All ingredients are taken in preset quantitative ratio. EFFECT: hair strengthening; antiinflammatory action on head skin with simultaneous removal of dandruff and skin itch. 4 cl, 2 tbl
PROBLEM TO BE SOLVED: To provide a method for producing an injection or dialysis solution containing a hydrogen carbonate having pharmaceutically permissible pH value and smallest fluctuation of respective regulated pH values by adding a specific compound to a solution containing the hydrogen carbonate and further performing a heat treatment thereof. SOLUTION: The objective injection or dialysis solution is produced by adding 2mmol/L, preferably 3mmol/L of at least one kind of carboxylic acid esters to a solution containing hydrogen carbonate and further heating the solution at &gt;=100 deg.C, preferably 121 deg.C in the method for producing an injection or dialysis solution containing a hydrogen carbonate. An ethanol ester, an isopropanol ester, a glycerol ester, a lactone, a carbonate ester, etc., are preferable as the carboxylic acid ester to be added. The objective solution contains hydrogen carbonate, especially sodium hydrogen carbonate, a pharmaceutically permissible carboxylic acid (e.g. acetic acid, propionic acid and lactic acid) and a pharmaceutically permissible alcohol and has pH6.9-7.8. The solution is used for a peritoneal dialysis by further adding a permeation-activating material (e.g. glucose).
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a factor promoting neovascularization, especially a factor promoting the wandering of endothelial cell.  &lt;P&gt;SOLUTION: The factor is a compound having the following properties(a) to (f), being useful as a neovascularization promoter or as a target molecule against a neovascularization inhibitor: (a) Being obtained by culturing HeLa cell in an EBM(-) medium at 37°C for 1-2 day, and found in the resultant culture supernatant. (b) Significantly promoting the wandering of normal human umbilical cord venous endothelial cell in chemotaxel assay. (c) Substantially promoting no proliferation of normal human umbilical cord venous endothelial cell. (d) Having a molecular weight of 10,000 or less. (e) Causing no substantial own deactivation by incubation at 60°C for 20 min. (f) Causing no substantial own deactivation when incubated at 37°C for 2 h in the presence of trypsin.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a film guard preparation capable of forming film on the skin for protecting hands and feet subject to physical shocks.  &lt;P&gt;SOLUTION: The film guard preparation is such as to be obtained by dissolving nitrocellulose in a dissolving agent, i.e. 3-methylbutyl acetate, isobutyl acetate or acetone, or a mixture thereof, followed by addition of ethyl alcohol. For the purpose of controlling the coefficient of friction and/or mechanical strength of film to be formed, an appropriate amount of a water-soluble polymer such as polyvinyl alcohol or polyvinylpyrrolidone may be incorporated in this preparation. Following applying this preparation onto the skin, the solvent is volatilized to form transparent or translucent film is formed on the skin as applied site(s) to seal up the affected site(s) and protect the applied site(s) with the film, thus mitigating or reducing external physical shocks on the skin and also protecting the skin from chemical irritation and/or bacterial infection.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
Antibodies that specifically bind the extracellular domain of IRT A3 immunoglobulin superfamily receptor translocation associated or that specifically bind the extracellular domain of IRTA5 are disclosed herein. Antibodies &#39; that specifically bind to IRT A3 do not specifically bind IRTAl, IRT A2, IRTA4, IRTA5, or IRTA6. Antibodies that specifically bind to IRTA5 do not specifically bind IRTAl, IRTA2, IRTA3, IRTA4, or IRTA6. The antibodies can be conjugated to effector molecules, including detectable labels, radionucleotides, toxins and chemotherapeutic agents. Nucleic acid molecules encoding these antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. Methods also are provided for detecting IRTA5 or for detecting IRT A3, as well as methods for treating various B cell malignancies. Methods are disclosed for assessing the efficacy of a therapy for an autoimmune disease.
The invention relates to medicine. The device for energy-information exchange between objects, the one of which represents an information source and the second object an information receiver, contains an electrical circuit (1), having a supply source (2), and the first contact element (3), for example a plate consisting of a conductive material which is electrically connected to the circuit (1), on which an information source - an ampoule with an original drug - is arranged. The device likewise contains a second contact element - an inductance coil (4a) - which is connected in the circuit (1). The information receiver - the carrier (6) - is arranged in the vicinity of the end of the coil (4a) such that the rotation axis cuts through the carrier (6). The device is preferably suitable for the production of homeopathic preparations having a different potency. &lt;IMAGE&gt;
FIELD: biotechnology. SUBSTANCE: probiotic, antibioticoresistant strain of Bacillus subtilis 3H &#34;ГИСК&#34; N 248 is obtained. Cell sizes: 1.5-4.0 mcm on 0.4-0.6 mcm. Cells are gram-positive, form spores but not - capsules, aerobic respiration. Strain grows on the different nutrient media. Strain splits glucose, sucrose, mannitol, maltose; it hydrolyzes starch, casein, urea, peptonizes milk, liquefies gelatin, reduces nitrates to nitrites, utilizes citrate, forms ammonia and hydrogen sulfide; strain does not split tyrosine, does not form hemolysin and fibrinolysin. Strain inhibits the growth of staphylococci, proteus, klebsiellae, Escherichia coli, yeast fungi, streptococci and pyocyanic bacterium. Strain shows resistance to polymixin and rifampicin, low sensitivity to penicillin, lincomycin and streptomycin. Strain can be used for preparation making from antibiotic group which can be used together with antibiotics. Preparation can be used for treatment of different infections, food allergy, disbacteriosis, enzyme insufficiency. EFFECT: preparing strain indicated above. 3 tbl
A sulphuric acid ester of oxytetracycline is prepared by reacting oxytetracycline or a salt thereof with a sulphur trioxide sulphonating agent in an anhydrous reaction-inert organic solvent at a temperature of from -50 DEG C. to 100 DEG C., the mole ratio of sulphur trioxide present in the reaction mixture to oxytetracycline being at least 1 : 1.  The sulphonating agent may be sulphur trioxide or a sulphur trioxide complex of N,N-dimethylaniline, dioxane, pyridine, N,N-dimethylformamide or of a tertiary base such as triethylamine or trimethylamine.  The ester has the formula &lt;FORM:0896452/IV (b)/1&gt; and can serve as intermediate for the preparation of a variety of substituted derivatives of tetracycline. It can, for example, be nitrosated in the D-ring or in the 4-position to give a nitroso derivative which can be converted to an amino derivative which can be converted to diazonium salts and various coupling products thereof.  The amino group can also be replaced by halogen, hydroxyl, nitro or arsonic acid by known methods.  The sulphuric acid ester can also be directly brominated, nitrated or sulphonated.ALSO:Pharmaceutical preparations comprise a pharmaceutical carrier and a sulphuric acid ester of oxytetracycline prepared by reacting oxytetracycline or a salt thereof with a sulphur trioxide sulphonating agent (see Group IV (b)) and having the formula &lt;FORM:0896452/VI/1&gt; The preparations may be in the form of capsules, tablets, aqueous or alcoholic solutions, ointments or salves.
PURPOSE:To obtain an application agent for external use with remarkably reduced occurrence of contact dermatitis and hardly any skin irritation, by blending a specific amount of a water absorbing high polymer in a plaster component. CONSTITUTION:An application agent for external use obtained by blending 1-20wt.%, preferably 1-8wt.% water absorbing high polymer as an essential ingredient in a plaster containing a tacky high polymer, drug effective ingredient, etc. The water absorbing high polymer absorbs water in an amount of 10 times or more based on the own weight to gel and swell and, e.g. a polymer prepared by introducing slight crosslinkages in an aqueous polymer, is used and blended as particles having &lt;=100mu, particularly &lt;=30mu particle size. The above-mentioned application agent is capable of sufficiently absorbing sweat causing the contact dermatitis without swelling and breaking the plaster even after absorbing the sweat. The whole plaster is moderately gelatinized by absorbing the sweat to reduce physical action, such as pulling out of hair.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for promoting nerve cell growth or myelination increase; to provide a pharmaceutical preparation for therapy of nerve or myelin drop diseases in nervous tissues; to provide a pharmaceutical preparation for treating central nervous system or peripheral nervous system neuron degenerative diseases; and to provide a pharmaceutical preparation for treating retinal nerve disorders.  &lt;P&gt;SOLUTION: Prosaposin and peptide derivatives derived therefrom promote neurite outgrowth in vitro. A peptide consensus sequence is determined by comparing the active neurite outgrowth-inducing saposin C peptide sequence with that of various hematopoietic and neuropoietic cytokines. These cytokine-derived peptides promote the same processes as their corresponding cytokines. In addition, prosaposin and saposin C promote increased nerve cell myelination ex vivo.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
PURPOSE:To provide a suppository having excellent sustained release effect, capable of freely regulating its sustained release extent, and capable of selecting the kinds of medicinal substances to be formulated from a wider range. CONSTITUTION:The objective sustained release suppository can be obtained by formulating (A) a suppository base with (B) a granular agent prepared by dispersing a medicinal substance in a sucrose fatty acid ester. The sucrose fatty acid ester, which is pref. &lt;=5, esp. 1-2 in HLB number, is used at 2-60 (pref. 3-20) wt.% of the final suppository. This suppository can be produced through the following processes: the sucrose fatty acid ester is heated to 70-90 deg.C to effect melting, the medicinal substance is then dispersed in the melt followed by cooling to effect solidification, the resultant solid is ground and the resultant granular agent is dispersed in the suppository base having been heated and melted in advance, the resultant dispersion is filled in a container and cooled. The sustained release extent of this suppository can be altered as desired through selecting the amount of the sucrose fatty acid ester be formulated, the HLB number of the sucrose fatty acid ester and the granular size of the granular agent.
A honeyed pill for treating infantile hernia is disclosed. The infantile hernia is common to children. The &#39;peritoneum processus vaginalis&#39; at the groin of children is not fully closed, and therefore small intestine, omentum, ovary, oviduct, and the like in the abdominal cavity can enter the processus vaginalis to generate hernia. The honeyed pill mainly comprises following raw materials by weight: 7-9 parts of parasitic chinaberry fruit, 7-9 parts of corydalis tuber and 2-5 parts of costus root. The honeyed pill is prepared by steps of: smashing the raw materials, sieving with a sieve having a size of 80 meshes, uniformly mixing refined honey and the raw material medicine powder according to a weight ratio of 1:1-1.5 to obtain a soft material, rubbing the soft material into strips, and preparing medicine pills with each pill containing 5-10 g of the crude drug, and packaging. The honeyed pill has functions of dispelling dampness, clearing away heat, promoting blood circulation to remove stasis, and promoting qi circulation to relieve pain, and is used for treating the hernia caused by body weakness, insufficiency of middle-warmer energy and stagnant qi-blood circulation. By clinical application and verification, the effective rate is 96.3% when the honeyed pill is used for treating 100 patients with the hernia, local and whole-body side effects are not found during the administration period, and the honeyed pill is safe to use.
FIELD: medicine, particularly, medico-biological studies. SUBSTANCE: preparations for integral correction of metabolic acidosis and alkalosis are not described in literature. Object of invention is use of preparation &#34;Namacyte&#34; (carbostimulin) for integral correction of metabolic acidosis and alkalosis. This object is accomplished owing to capability of above said preparation to normalize acidic-alkaline status and metabolic processes occurring in tissues. EFFECT: normalization of acidic-alkaline status and metabolic processes. 4 tbl
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a bARE composition which is stable in storage and has sequentially a long-term activity.  &lt;P&gt;SOLUTION: The composition contains a substantially integral bARE class protein and in one embodiment, the composition contains a stabilizer which comprises a charged amino acid or the analog thereof. In another embodiment, the stabilizer contains an arginine or a phosphoarginine which is present in an amount of approximately 100-400 mM. In a further embodiment, the composition contains an uncharged substance or the analog thereof or an amphoteric substance. The amphoteric substance is an amphoteric surfactant which comprises 3-(3-cholamidopropyl)-dimethylammonio-1-propanesulfonate (CHAPS).  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a composition of a metal oxide or hydroxide having a fine particle form, excellent in dispersibility in an organic dispersant.  &lt;P&gt;SOLUTION: This fine particle metal oxide or hydroxide-fatty acid complex is produced by passing through the processes of reacting a metal salt with an alkali in the presence of the fatty acid and/or its salt to form the complex of the metal oxide or hydroxide with the fatty acid, then cleaning products other than the complex and drying. As the fine particle metal oxide in the fine particle metal oxide-fatty acid complex, zinc oxide is preferable. As the fatty acid, that of a 6 to 30C is preferable. By passing through such the production processes, the metal oxide/hydroxide complex having a scale like form and easily dispersing in the organic dispersant can be obtained.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
The invention discloses a scolopendra polysaccharide-protein composition troche, which can prevent and cure hepatic trauma diseases. The tablet comprises scolopendra polysaccharide-protein composition (SPPC), filling agent, adhesives, disintegration agent, humectant and lubricant with constant proportion with reasonable prescription and convenient application. The steps of preparation is: &lt;1&gt;after the filling agent, the adhesives and the disintegration agent are added into SPPC separately, the humectant is added and mixed homogeneously and soft strip is prepared; &lt;2&gt; the homogeneous soft strip is screened through nylon sieve with 50-200 holes, dried under 70-80 DEG C and granule through iron sieve; &lt;3&gt;finally, adding into the lubricant and prepare troche. The medicinal composition has highly effective anti-liver damage activity and has effective improvement and recovery action to a plurality of experimental liver damage through proving. Acute and toxicity test indicates that toxin toxic and side effects are low. Therefore, the invention is applied in preventing and curing the hepatic trauma diseases, which is characterized by high property in protecting liver activity, and innocuity etc.
PURPOSE:To obtain a dispersion of solid in liquid in which an oil-soluble substance is homogeneously and stably dispersed in an aqueous solution in a solid state. CONSTITUTION:In this dispersion of solid in liquid, an oil-soluble substance is dispersed in an aqueous solution of a watersoluble hemicellulose in a solid state. The oil-soluble substance is a substance which has a solid content of &gt;=90wt.% at 20 deg.C and a melting point of &gt;=40 deg.C, especially, &gt;=100 deg.C and is insoluble or slightly soluble in water. The oil-soluble substance is e.g. a chemical which is effective as an agrochemical or an insecticide (e.g. 1-naphthyl-N-methyl carbamate or tetrachloroisophthalonitrile) or a high-melting oil and fat which is effective as an indigestible oil and fat. A bean e.g. soybean, especially, originated from a cotyledon is preferable as the above mentioned water-soluble hemicellulose. Preferably 0.05-25 pts.wt., especially, 1-20 pts.wt. of the oil-soluble substance is dispersed against 1 pts.wt. of the water-soluble hemicellulose. The oil-soluble substance is preferably pulverized into fine particles having an average particle diameter of &lt;=40mum, especially, &lt;=10mum. By dehydrating the dispersion of solid in liquid, a hydrate capable of easily being wetted and dispersed into water is obtained.
PURPOSE:A hypertension preventive that contains, as an active ingredient, a high-molecular-weight substance which is obtained by removing cell bodies and casein from fermented milk, thus being a labor-saving product with good hypotensive action without side-effects. CONSTITUTION:Cell bodies and casein are removed from fermented milk to give a substance of 5,000 or more molecular weight and it is used as a hypotensor. The fermented milk is produced by fermentation of animal or soybean milk with a lactobacillus or a combination thereof with yeast until the count of cell bodies reaches over 10&lt;7&gt;/ml. The resultant fermented milk is adjusted in its pH nearly to the isoelectric point of casein to effect the precipitation of casein, then filtration is carried out to remove casein and cell bodies. The supernatant is subjected to ultrafiltration, then dialysis to collect the fraction corresponding to 5,000 or more molecular weight. The resultant fraction or its processed products are used as a medicine or health food.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a drink and a supplement which each is prepared from natural materials as raw materials, is little in side effects, can be taken over a long period, and is effective for improving metabolic syndrome.  &lt;P&gt;SOLUTION: The drink or supplement having a metabolic syndrome-improving action contains a processed Eucommia ulmoides Oliver, a processed Monascus and a Larix sibiricia Ledeb.(Pinaceae) extract. The processed Eucommia ulmoides Oliver is a Eucommia ulmoides Oliver extract, and the Larix sibiricia Ledeb.(Pinaceae) extract is the extract of the cambium layer or wooden portion extract of Larix sibiricia Ledeb.(Pinaceae). A drink prepared by combining the processed Eucommia ulmoides Oliver with the processed Monascus and the Larix sibiricia Ledeb.(Pinaceae) extract is effective for improving metabolic syndrome.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
PURPOSE:To obtain the subject new compound useful for imaging a brain. CONSTITUTION:A compound of formula I (R is H, a 1-8C alkyl excluding methyl or propyl, a 1-8C aminoalkyl, a 2-16C alkoxyalkyl, a 4-13C alkyl-cycloalkyl, a 2-5C alkenyl or a 2-5C alkynyl), e.g. 1-N-(2-mercapto-2-methyl-1-oxopropyl)-2-N &#39;-[2-(S-ethylthio)phenyl@9147/28} diaminoethane. The compound of formula I is obtained by deacetylating a compound of formula II in the presence of sodium hydroxide equivalent to the compound. The compound of formula I is made to react with a radioactive metal to provide a radioactive metal complex and the metal complex is useful as a radioactive diagnostic agent. The compound of formula I is also high in stability after formation of its chelate compound and rapidly incorporated into a brain after administration and retained for proper time and the compound has low blood level after in vivo administration as well as good clearance.