anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
Compositions for use in the regulation of subnormal pH values in the intestinal tract and for treatment of bowel diseases. The compositions comprise a coating and a substantially insoluble alkaline material confined within said coating, the composition being adapted so as to ensure the availability of an amount of said pH regulating alkaline material in the lumen of the gastrointestinal tract exhibiting subnormal pH values. E.g. in the proximal small intestine, the mid small intestine, the distal small intestine, the caecum, the ascending colon, the transverse colon, the descending colon, the sigmoid colon and/or the rectum. The compositions may also comprise a medicament for treatment of bowel diseases, e.g. 5-aminosalicylic acid for the treatment of Crohn&#39;s disease and colitis ulcerosa. The administration may be oral compositions or enemas or suppositories.
279,445. I. G. Farbenindustrie Akt.- Ges. Oct. 20, 1926, [Convention date]. Medicines for internal use. - Hormones, influencing the action of the heart, which are soluble in water but not in strong alcohol, are obtained from the hearts of warm-blooded animals by extraction with water or with aqueous organic solvents, ballast substances such as albumens and lipoids being removed from the extracts by known methods. According to an example, comminuted hearts are extracted with water, the solution is concentrated if necessary, impurities are removed by adding alcohol up to 60 per cent strength and by cooling, the filtrate is desiccated, lipoids are dissolved out by high strength alcohol, and the hormone remaining is dissolved in water and sterilized by heating or by adding an antiseptic. Reference is made to a known alcohol-soluble heart hormone obtained from the hearts of coldblooded animals, to an alcohol-soluble substance obtained by extracting heart tissue with Locke&#39;s solution according to Specification 250,230 (as open to inspection under Sect. 91 of the Acts), and to Specifications 306,606 and 306,608. The Specification as open to inspection under Sect. 91 (3) (a) contains also the subject-matter of Specifications 306,606 and 306,608 and states that lipoids removed from an aqueous solution of heart hormone by treatment with a solvent such as methylene chloride may be freed from solvent by evaporation and from phosphatides by treatment with acetone. This subject-matter does not appear in the Specification as accepted.
PURPOSE:An improve for serum lipid useful as a food, or a drug, having improved reducing effect on free cholesterol and LDL cholesterol by a synergistic action, containing a specific triterpene alcohol and an a highly unsaturated oil. CONSTITUTION:The titled composition containing a triterpene alcohol selected from cycloartanol, 24-methylcycloartanol, and 24-methyulenecycloartanol and a highly unsaturated oil containing &gt;=3 double bonds in the molecule. Eicosapentaenoic acid, eicosatetraenoic acid, linolenic acid, squalene, etc., may be cited as the highly unsaturated oil. An animal or vegetable oil containing them can also be used. The titled composition reduces extremely free cholesterol and LDL cholesterol, raises HDL cholesterol ratio in the-blood, and has good improving action on serum lipid. It also has high safety.
PROBLEM TO BE SOLVED: To obtain a skin protecting agent consisting of a neutral solution of a chitosan, good in feeling in use and high in safety, while holding a humidity maintaining property. SOLUTION: This skin protecting agent is obtained by dissolving a highly deacetylated chitosan, preferably a squid chitosan having &gt;=75% deacetylation ratio, with 0.01-5wt.% organic acid buffer solution (e.g.; glutamic acid) and then neutralizing with the addition of an aqueous alkaline solution (e.g.; NaOH) to prepare a preparation fitted to pH4.5-6.5. It is prepared as a lotion, cream, etc. In contrast to the chitosan derived from a crab or a shrimp induces an allergy, the squid chitosan does not induce the allergy and is preferable in view of its safety. The chitosan as an inexpensive natural polymer is used as an industrial waste water treating agent, a growth promoter for agricultural products, a covering membrane for an injured skin, etc.
The invention discloses a traditional Chinese medicine foot-bath life-cultivation and health preservation formula for invigorating blood circulation, dispelling wind and relieving itching. According to the life-cultivation principle of &#39;&#39;protecting root before planting trees and protecting foot before cultivating people&#39;&#39;, seven raw materials including 15-20 g of Angelica sinensis, 15-20 g of rheum officinale, 15-20 g of radix sophorae flavescentis, 15-20 g of common cnidium fruit, 15-20 g of clematis root, 10-15 g of Amomum villosum Lour shell and 8-12 pieces of onion are selected for preparation of the formula. The preparation and application method comprises the following steps: firstly chopping raw materials, pouring the raw materials into a marmite, adding 1000-1200 ml of water, decocting for about 30-40 min, pouring into a nonmetal foot basin, adding 3-5 kg of 38-40 DEG C hot water obtained after two times of boiling and one time of cooling until the product is over the ankle joint for foot bath. Foot bath generally lasts for half an hour. Users also can seat on the foot basin to immerse scrotum in the product. Then, the effect is better. The formula for foot bath and hip bath is applied 1-2 times a day, and 3-5 days of application is a treatment course. The formula has effects of invigorating blood circulation, dispelling wind and relieving itching, and can cure scrotum rot disease, etc.
A total of 50 patients were included in the study. Deep paravertebral periforaminal ozone injection was administered to the patients in the ozone injection group 4 times under ultrasound guidance, 10 ug/ml 5ml twice a week in the first week and 15 ug/ml 5ml twice a week in the second week. In the transforaminal epidural steroid injection group, steroid (dexamethasone 8mg/2ml 2ml) injection was performed under the guidance of fluoroscopy. The patients in both groups were offered a home exercise program for therapeutic waist and abdominal muscles to do during the treatment follow-up period. Patients\&#39; quality of life was evaluated with SF-36(Short Form-36), pain scores with VAS(Visüel Analog Scala) and functional evaluations with ODI(Oswestry Disability Index) at 15 days, 1 month, and 2 months. Physical examination findings were evaluated before starting the treatment and at the 2nd month follow-up.
PURPOSE:To provide a reverse transcriptase-inhibiting composition exhibiting a reverse transcriptase-inhibiting activity and useful for inhibiting the multiplication of retro virus by containing a protoberberine type alkaloid. CONSTITUTION:The composition contains a protoberberine type alkaloid such as a compound of the formula (R&lt;1&gt; and R&lt;2&gt; are H, methyl, etc., R&lt;3&gt; and R&lt;4&gt; are H, methyl, etc.; X&lt;-&gt; is anion). The compound of the formula, etc., may be used singly or as a mixture of two compounds or more. The composition can be employed for the prevention and treatment of the acquired immunodeficiency of a mammal animal, particularly human immunodeficiency virus or adult T cell leukemia. The dose is 5-500mg, preferably 20-400mg, a day for an adult as the active ingredient.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a new molecule for immuno-regulatory and enhancing actions.  &lt;P&gt;SOLUTION: An isolated peptide or polypeptide containing an amino acid sequence: VSIGLSFPMLP or its analog or derivative, wherein the peptide or polypeptide has a characteristic for enhancing an immuno-response against an antigen, when administered in a mammal. In an embodiment, the peptide or polypeptide has a length of 11 amino acid bases to 200 amino acid bases. In another embodiment, the peptide or polypeptide has a length of 11 amino acid bases to 20 amino acid bases. In the other embodiment, the peptide or polypeptide contains the amino acid sequence.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
NEW MATERIAL:A germanium-alkali mixed salt of an organic acid composed of an alkali metal germanate and an organic acid. EXAMPLE:Germanium sodium citrate. USE:A component of herb used as a remedy for cancer, etc. It has excellent absorbability in living body, especially in vegetable because the germanium acts as an organic substance in place of inorganic substance. PREPARATION:An aqueous solution of an alkali metal germanate is produced by boiling germanium oxide and an alkali (e.g. sodium hydroxide) usually in water under agitation. 1mol of the produced alkali metal germanate is made to react with usually &gt;=6 base equivalent of an organic acid (e.g. malic acid, citric acid, etc.).
A cap, e.g. a mobcap, comprising an acid which is chemically not bonded thereto, may be used to neutralize ammonia released during hair coloration by: &lt;SL&gt; &lt;LI&gt;(a) applying to hair an oxidative dye composition comprising aqueous ammonia and &lt;LI&gt;(b) subsequently cover the hair with such a cap. &lt;/SL&gt; A package comprising such a cap and an oxidative hair colorant product is also provided. Suitable acids include citric acid, formic acid, lactic acid, acetic acid, malic acid, hypochloric acid and sulphuric acid. The cap may comprise an absorbent layer, e.g. of a cellulosic (such as paper), wool, cotton or suitable polymeric material. The cap may also comprise a pH-sensitive colour indicator (to indicate when the hair colouration process has finished), a perfume and a malodour counteracting agent.
This invention discloses a process for making nanopanticles of amphiphilic copolymers by flash precipitation. Nanoparticles may be of amphiphilic copolymer alone or may contain an additive target molecule, preferably an organic active. The inclusion of additive target molecules in amphiphilic copolymer nanoparticles can alter their water solubility characteristics, fluid dynamics, and/or stability. Changing an additive target molecule&#39;s solubility and stability in an nanoparticle can make a water insoluble compound suitable for pharmaceutical administration as well as specifically target the molecule to a specific area of a patient&#39;s body. The process affords the production of nanoparticles at high absolute active content, at high yield, high productivity, and high processing rates while using unusually low amounts of amphiphilic copolymers. Furthermore, the resulting particles exhibit sufficient stability for post processing as desired. The invention also discloses two apparatuses for the production of nanoparticles of amphiphilic copolymers by flash precipitation.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a medical mistake preventing system and a composite photographing device for preparing a chart photograph.  &lt;P&gt;SOLUTION: In the medical mistake preventing system, the entry fields of a reception card are provided with a patient&#39;s attribute information description field including the data of birth, sex, and the name of a patient. Prescribed items with an autograph by the patient or a person interested are described in the description field. The composite photographing device automatically collates the patient&#39;s attribute information with the reception card with the contents of the reception card confirming or collates the patient&#39;s attribute information previously memorized by a receptionist with the reception card. After confirming agreement, the reception card is photographed. In addition, a photographic camera is moved to an appropriate location for adjustment to photograph the face photograph of the patient. The appropriate sheets of the sealed chart photographs integrating the patient&#39;s attribute information on the reception card with the face photograph are printed on a sheet of paper. The chart photographs are stuck on a medical information means requiring personal confirmation.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
A system and method for communicating data from a medical device to a lighting device is provided. The system may include the medical device, the lighting device, and/or one or more interface devices. The medical device may be configured to transmit data to the lighting device, which for example, may include information relating to the medical device, dosage information, diagnostic data, medical device training feedback, health monitoring information, and/or air quality information. The lighting device may be configured to receive data from the medical device and control one or more lighting characteristics based on the received data. A characteristic of the light may include one or more of color, color temperature, intensity, flashing or steady-state, on or off, and/or the like. The system may provide for a home based adherence and/or compliance monitoring system, in which a patient&#39;s interaction with a medical device may be monitored and an alert/indication provided.
NEW MATERIAL:A compound expressed by formula I (R represents H, OH or hydroxysulfonyloxy) exhibiting the following various characteristics. Color reaction; positive to Ehrlich&#39;s reagent, chloroplatinic acid reaction and molybdic acid reaction and negative to ninhidrin reaction. Paper chromatography; Rf value 0.03(developing solvent; acetonitrile, HCl and EDTA). High-voltage filter paper electrophoresis: 11-12cm to the anode. USE:An antibacterial agent having strong antibacterial potency and beta-lactamase inhibitory activity. PREPARATION:A material prepared by washing cultured bacteria of Brevibacterium.ammoniagenes (ATCC 6871) is reacted with a substrate of an antibiotic OA-6129 A, B or C expressed by formula II under normal enzymic reaction conditions in the presence of adenosine-5&#39;-triphosphate.
PURPOSE:A hair rinse composition having improved easy hairdressing and set retaining ability, containing a monoalkyl quaternary ammonium salt, and a phosphoric ester of an addition polymer of a compound containing active hydrogens with a polyoxyalkylene oxide. CONSTITUTION:A hair rinse composition containing (A) 0.1-20wt% monoalkyl quaternary ammonium salt, and (B) 0.1-30wt% phosphoric ester of addition polymer of a compound containing 2-6 active hydrogens with a polyoxyalkylene (0-50wt% oxyethylene content). The hair rinse has both rinse providing effect such as flexibility and hairdressing providing effect. A compound shown by the formula (R&lt;1&gt; is 8-22C alkyl, or hydroxyalkyl; R&lt;2&gt;-R&lt;4&gt; are alkyl, benzyl, etc.; X is halogen, etc.) is used advantageously as the component A, and an alcohol, polyalkylene polyamine, etc. is preferable as the compound containing active hydrogens of the component B.
NEW MATERIAL:A compound shown by the formula I (R is anthracycline compound residue; wavy line is double bond of E form or Z form or their mixture). EXAMPLE:An acid amide of dl-DELTA&lt;7&gt;-Prostaglandin A1 and daunomycin. USE:Having carcinostatic action, antiviral action, and antimicrobial action. Showing improved cancer cell multiplication inhibitory action especially on L-1210 leukemia. PREPARATION:DELTA&lt;7&gt;-Prostaglandin A1 shown by the formula II and an amine shown by the formula R-NH2 are subjected to an acid amide formation reaction in the presence of a condensation agent (e.g., dicyclohexylcarbodiimide) in a solvent such as dichloromethane, etc. at 0-30 deg.C to give a compound shown by the formula I.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide formulations and methods for administration to thereby improve the compliance and amenity for patients during treating disorders or troubles of breasts and thoracic parts.  &lt;P&gt;SOLUTION: Formulations for topical or local administration of drugs directly to the breast or chest to produce a regional or local effect with lower systemic drug levels than when an effective amount is administered systemically are disclosed herein. In a preferred embodiment, the drug is administered to the surface of the breast, areola, or directly to the nipple. The formulation provides increased patient comfort, increased bioavailability and a relatively high blood level in the region to be treated with a reduction in side effects compared to that administered systemically. A preferred formulation includes drugs in the form of micro or nanoparticles, which may be formed of a single drug or in combination with an excipient or carrier.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PURPOSE:To obtain an immunostimulant containing a diglyceride compound as an active component, having excellent immunostimulating activity and safety and capable of effectively stimulating immune response at infection, etc. CONSTITUTION:This immunostimulant contains, as an active component, a diglyceride of the formula (two groups of R&lt;1&gt; to R&lt;2&gt; are acyl groups derived from saturated or unsaturated aliphatic acids of 12-22C and the rest of them is H). The immunostimulant can be formulated as a tablet, a capsule, powder, granules, syrup, an injection, an enteral formulation, etc. The daily dose for an adult is conventionally 1-70g as diglyceride. A diglyceride of the formula is obtained by subjecting a mixture of fat and oil and glyceral to transesterification in the presence of a hydroxide compound of an alkali metal and/or an alkaline earth metal. The immunostimulant is free from a side effect even at daily administration or intake and free from an influence on the taste when added to foods, etc.
Provided are methods for optimizing therapy of, treating a patient having, or selecting (identifying) patients who will benefit from treatment for, a cancer (e.g., a non-hematological cancer; e.g., a gynecological cancer). The methods comprise determining whether the patient will benefit from treatment with an ErbB3 inhibitor (e.g., an anti-ErbB3 antibody), with or without either a taxane or an aromatase inhibitor, or with a taxane or an aromatase inhibitor in the absence of an ErbB3 inhibitor, based on levels of particular biomarkers and combinations of biomarkers measured in a biological sample obtained from the patient. The methods further comprise optimizing the patient&#39;s therapy, selecting the patient for treatment, or treating the patient accordingly. In various aspects the biological samples are sections of a biopsy (e.g., a formalin fixed paraffin embedded biopsy). In oth6er aspects the biomarkers are proteins and/or nucleic acids. In other aspects the biomarkers function in ErbB-mediated signal transduction.
The present invention is directed to the induction and characterization of a humoral immune response targeting &#34;entry-relevant&#34; gp41 structures. In its broadest aspect, the present invention is directed to methods of raising a neutralizing antibody response to a broad spectrum of HIV strains and isolates. The present invention targets particular molecular conformations or structures that occur at the cell surface of HIV during viral entry into host cells. Such a humoral response can be generated in vivo as a prophylactic measure in individuals to reduce or inhibit the ability of HIV to infect uninfected cells in the individual&#39;s body. Such a response can also be employed to raise antibodies against &#34;entry relevant&#34; gp41 structures. These antibodies can be employed for therapeutic uses, and as tools for further illuminating the mechanism of HIV cell entry.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide polynucleotide binding complexes comprising sterols and saponins.  &lt;P&gt;SOLUTION: The invention relates to complexes comprising sterols and saponins. The complexes can bind a genetic determinant, for example a polynucleotide. The complexes may further comprise a lipophilic moiety, optionally a lipophilic moiety comprising a contact group and/or a targeting ligand and/or a saccharide moiety. The complexes may further comprise an immunogenic determinant and/or an antigenic determinant and/or a medicament and/or a diagnostic compound. The complexes may in further embodiments be encapsulated by an encapsulation agent, for example, a biodegradable microsphere. The invention also pertains to pharmaceutical compositions and methods of treatment of an individual by therapy and/or surgery, methods of cosmetic treatment, and diagnostic methods practiced on the human or animal body.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
A cotton wool pad produced by water jet needling has a surface pattern on one side with recesses comprising at least 55 %, preferably 85 to 95 %, of the area, separated by narrow, e.g. less than 95 mm wide, ridges. The internal strength is at least 0.55 N, preferably 0.75 N per 25.5 cm2&gt;. Preferably the area of a recess is 20 to 40 mm2&gt;, the ridge spacing 0.5 to 1.5 mm, the ridge depth 0.1 to 0.2 mm, the pad 3 mm thick with a weight of 220 to 260 g/m2&gt;. An independent claim is also included for the manufacturing process consisting of wetting a fiber layer with a pressure of 3 to 7 bar and then water-jet punching on both sides at 8 to 12 bar. This is followed by further water-jet punching on one side at 22 to 30 bar through a steel stencil or mask with the required pattern etched or laser cut in it, and which is mounted on a rotating drum.
Recombinant cultivable mycobacteria capable of expressing DNA of interest which encodes at least one protein antigen against which an immune response is mycobacteria.   In the recombinant mycobacteria, the DNA of interest is stably maintained extrachromosomally or is stably integrated into genomic DNA.  Such recombinant mycobacteria are useful as vehicles to be used as vaccines to provide immunity against a pathogen, as anti-fertility &#34;vaccines&#34; and as a means to nonspecifically augment immune responses to foreign antigens expressed by BCG or to treat human cancers. The present invention also relates to recombinant vectors useful in introducing DNA of interest into mycobacteria, where it is expressed.  One type of vector is a recombinant phasmid capable of replicating as a plasmid in E. coli and of lysogenizing a mycobacterial host.  A second type of vector is a recombinant plasmid which can be introduced into mycobacteria, where it is stably maintained extrachromosomally.  A third type of recombinant vector is one which replicates in E. coli but not in mycobacteria.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for producing a cancer cell by using a cancer gene, a method for detecting cancers by using the cancer gene, a method for screening a compound having an effect for treating and/or preventing the cancers and to provide a medicinal composition for treating and/or preventing the cancers.  &lt;P&gt;SOLUTION: The method for producing the cancer cell comprises excessively expressing a CD39L4 gene with cell and selecting a cell strain in which proliferation ability of the cell is changed. The method for detecting the cancers uses expression of CD39L4 as an index. The new method for screening the compound having effect treating and/or preventing the cancers comprises using CD39L4. The medicinal composition comprises an antibody specifically recognizing CD39L4.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
A method of providing halotherapy to the upper portion of the lower respiratory tract includes the steps of operating a dispenser and inhaling. The dispenser contains a dry sodium chloride powder. The user operates the dispenser to release a dosage of the powder for inhalation when the dispenser is aimed into the user&#39;s mouth. The user then inhales the dosage of powder through the mouth. Because the powder has a particle size range enabling the powder to target the upper portion of the lower respiratory tract without entering the user&#39;s lungs, the dosage of the dry powder provides a concentration at the upper portion sufficient to provide effective halotherapy. The preferred particle size range is from about 5 microns to about 20 microns. The preferred dosage is about 3 milligrams of powder.