anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
FIELD: medicine. ^ SUBSTANCE: invention refers to medicine and may be used in neurology, traumatology, physiotherapy, orthopaedics, in stepped therapy of protrusions, herniated disks, scoliosis, kyphosis, kyphoscoliosis, spondylolisthesis, osteochondrosis, myofascial syndrome, myositis, vertebrogenic (discogenic) torticollis, intercostal neuralgia, lumbago, lumbar ischialgia. The I stage consists in intravenous blood exposure to UV and red low-intensity laser emission, graduated uniform extension of all spinal segments in a traction apparatus with no fixation devices with considering patient&#39;s anthropometric data in complete muscular relaxation. The stage II consists of two alternating series of procedures. The series I implies paravertebral vacuum cup massage from both side upwards from a lumbar to cervical spine along massage lines of the back with a cup tightly pressed to skin. It is followed with vacuum gradient therapy with using a number of cups of different volumes and sections simultaneously along a venous outflow. Further, a leech therapy (LT) covering an umbilicus, a swing therapy (ST) in the SWING MACHINE training facility. The series II includes a one-day acupress therapy of the spinal muscular frame with using ebonite rollers along massage lines of the back, then - manual exposure on its musculo-ligamentous apparatus and joints in the form of various massage types, a yumeiho therapy, a postisometric relaxation, further the LT and the ST on the back area. The days free from the manual exposure and the LT on the back area; the ST is followed by physical exercises based on the system of traditional Cigun, Nishi, yoga techniques The stage III provides diagnosis and orthopaedic feet correction. ^ EFFECT: therapeutic effect is ensured by exposure on all the pathogenesis patterns of the spinal diseases: cell, immune, humoral, neuromuscular, mechanical, reflex, at the level of the integrated system, including principal drug-free recovery of the spinal health. ^ 6 cl, 5 dwg, 5 ex
The rhizomes of Ruscus aculeatus L. (Lileaceae) (butcher&#39;s broom or knee holly) are extracted with a satd. aqs. soln. of n-butanol, the butanolic phase is evaporated, the residue is taken up in an alcohol, pref. MeOH, and the saponins precipitated with a suitable agent. The agent used to precipitate the saponins is pref. a mixture of ether and acetone. The crude saponins may be purified by chromatography on an alumina column. Saponins are of use in the pharmaceutical industry.
PURPOSE:To obtain a new substance D329, having excellent antitumor activity and high water solubility and useful as an anticancer agent with hardly any toxicity by culturing a microorganism, belonging to the genus Streptomyces and having the ability to produce the substance D329. CONSTITUTION:A microorganism [e.g. Streptomyces.chartreusis D329-185 strain (FERM BP-3269)], belonging to the genus Streptomyces and having the ability to produce the substance D329 expressed by formula I (R&lt;1&gt; is a group expressed by formula II, etc.; R&lt;2&gt; is a group expressed by formula III, etc.) or its derivative is inoculated into a culture medium and cultured at 30 deg.C for 4 days by shaking to prepare a primary culture solution, which is then inoculated into a culture medium and cultured at 30 deg.C for 16 days by shaking. The obtained culture solution is subsequently centrifuged to collect microbial cells. Acetone is then added to the resultant microbial cells and the prepared mixture is stirred at ambient temperature for 5hr to carry out the extraction. The resultant extract solution is concentrated under reduced pressure and the obtained concentrate is subsequently extracted with n-butanol to concentrate the extract solution under reduced pressure. The obtained crude extract is then purified by chromatography to afford the substance D329 (derivative), having the antitumor activity and expressed by formula I.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an assay for identifying beta-secretase inhibitor, and to provide a screening method.  &lt;P&gt;SOLUTION: This assay for identifying inhibitors of beta-secretases comprises the steps of immobilizing a beta-secretase protein on a solid support, contacting it with a test compound in the presence of a tagged beta-secretase inhibitor, and comparing the extent of binding of the tagged beta-secretase inhibitor in the presence and in the absence of the test compound in order to evaluate if the test compound is an inhibitor of beta-secretases. A method of screening for inhibitors of beta-secretases. Novel beta-secretase inhibitors and their use as tagged beta-secretase inhibitors for identification of inhibitors of beta- secretase. A kit for identifying beta-secretase inhibitors. Novel beta-secretase inhibitors for use in the treatment of Alzheimer&#39;s disease and other cerebrovascular amyloidosis.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an expression vector capable of efficiently expressing an allergen protein in a leguminous plant, to provide a method for producing a transformant plant transduced with the expression vector, to provide the resulting transformant plant, and to provide uses of the plant.  &lt;P&gt;SOLUTION: The allergen protein can be produced/accumulated in a leguminous plant by transducing the expression vector into e.g. a Lotus japonicus plant. By oral administration of the leguminous plant, the plant can be used in the oral hyposensitization therapy for allergic diseases. One example of the allergen protein is DerfI protein derived from Dermatophagoides farinae.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
FIELD: medicine.SUBSTANCE: invention relates to medicine, namely to oncology, and can be used to treat metastatic cancer in patients. For this purpose, percentage of T-cytotoxic lymphocytes of the peripheral blood CD8 subpopulation with receptors of programmed cell death (PD-1) in relation to the total number of lymphocytes of this subpopulation (the content of PD-1-positive T-lymphocytes). Therapy is three-staged. At the first stage, a complex procedure is carried out, including the impact on the patient&#39;s skin surface by pulsed-periodic laser radiation and subsequent administration to the zone of said effect of the composition containing the Sendai virus, or the introduction of recombinant human HSP70 (Preparation-1 HSP70). In the second stage, these complex procedures are reassigned and additional fusion protein is introduced based on rchHSP70 and Fc fragment of human immunoglobulin G (Preparation-2 HSP70). In the third stage, depending on the size of the tumor, the metabolic activity of the tumor tissue, the content of PD-1-positive T-lymphocytes, the patient is additionally assigned a positron-emitting radionuclide conjugated to a tumor-specific substance.EFFECT: invention provides treatment of metastatic cancer in a patient.23 cl, 22 tbl, 8 ex
A system for managing prescriptions. The system includes a server to operate a prescription manager, and a client. The server includes a processing device and a memory. The prescription manager includes an attachment receiver to receive an audio recording from a prescription signatory authority. The audio recording indicates approval of a prescription for a patient. The client interacts with the prescription manager and is in communication with the server via a network. The client includes a microphone to convert the prescription signatory authority&#39;s voice to an electronic signal to generate the audio recording.
The invention relates to a dosage form that is suitable for releasing an active ingredient over a long period of time. For this purpose, the active ingredient is released in two-stages in order to do away with an excessively frequent ingestion of the dosage form. The dosage forms according to the invention are for treating dizziness in humans. They are administered with or after a meal. The concept according to the invention provides that the pharmaceutical form has a dimensionally stable portion which, after ingestion of the dosage form by the patients, does not dissolve in the chyme-filled stomach for a number of hours. In this way, this dimensionally stable portion remains in the stomach until same is evacuated by the so-called &#34;housekeeper waves&#34;. Another portion of the dosage form is formed in such a way that it dissolves within a short time of the patients ingesting same. In this way, a quick invasion of the active ingredient with corresponding plasma levels is ensured.
PURPOSE:To produce an oiling gel useful as a base for cosmetics and endermic medical goods by adding hydrogenated lecithin to liquid paraffin, heating the same to melt, and allowing the melt to cool thereby solidifying the melt to a gel. CONSTITUTION:&gt;=5pts.wt. lecithin such as hydrogenated soybean lecithin is added to 100pts.wt. mixture of 1 or &gt;=2 kinds among hydrocarbon oils such as liquid paraffin, squalene, alpha-olefin oligomer, liquid polyisobutyrene or the like or a liquid oily mixture prepd. by mixing vegetable oil such as olive oil and liquid higher fatty acid ester such as isopropyl myristate or the like with the same a mt. or above of hydrocarbon oil and after both are uniformly mixed, the mixture is heated to about 60 deg.C to melt the hydrogenated lecithin, then the melt is allowed to cool. A virtually transparent oily gel is obtd. and is adaptable as a base for cosmetics and endermic medical goods.
Self-assembling peptides or self-assembling peptidomimetics (&#34;SAP&#34;) can treat inflammation or inflammatory diseases, or reduce one or more symptoms of diseases and disorders associated with undesirable inflammation. Topical and injectable compositions of SAP for local administration to a site of inflammation for reduction or prevention of symptoms of inflammatory diseases and disorders are described. The compositions include one or more SAP in an amount and concentration effective to reduce or prevent one or more symptoms of undesirable inflammation. The SAP can assemble prior to or after the composition is administered. The SAP form a structure within or at the surface of the body that prevents and/or reduces symptoms associated with inflammation and other dysregulated immune processes. The peptides can assemble upon contact with bodily fluids ( e.g. , synovial fluid), or can be contacted with ionic solutions to initiate assembly.
Emergency access procedure for defibrillators. The invention refers to a procedure for accessing defibrillators from the remote opening of an access door or sending access door opening codes: 1. The user requests to communicate the emergency and a computer system obtains the location of the defibrillator. user thanks to the GPS positioning of the user&#39;s mobile device. 2. Indicates how to get to the nearest defibrillator. 3. The computer system remotely sends an opening signal to the access door or a code to open the access door. 4. The computer system sends a notification about the situation to certain pre-established contacts.  (Machine-translation by Google Translate, not legally binding)
The invention discloses a loading medicine adipose-derived mesenchymal stem cell polypeptide hydrogel support and a preparing method thereof. The preparing method includes the steps that (1) ultrapure water is used for preparing a citric acid tamoxifen solution with the concentration ranging from 1.836x10&lt;-5&gt; M to 2. 651x10&lt;-5&gt; M; (2) polypeptide hydrogel containing citric acid tamoxifen with the concentration ranging from 1.836x10&lt;-5&gt; M to 2. 651x10&lt;-5&gt; M is formed in a culture plate; (3) a solution in the polypeptide hydrogel obtained in the step (2) is replaced through the citric acid tamoxifen solution with the concentration ranging from 1.836x10&lt;-5&gt; M to 2. 651 x10&lt;-5&gt; M in a washed manner until the PH is 7.0; and (4) adipose-derived mesenchymal stem cells of a person are taken according to the standard that each milliliter contains 1.0x105 adipose-derived mesenchymal stem cells, 500 microliters of adipose-derived mesenchymal stem cells are added into each hole, cultivation is carried out for 3 days, and then the loading medicine adipose-derived mesenchymal stem cell polypeptide hydrogel support is obtained. The polypeptide hydrogel support contains both anti-cancer medicine citric acid tamoxifen and the adipose-derived mesenchymal stem cells of the person, and can be used for constructing the living tissue.
PURPOSE:To simultaneously satisfy mechanical strength, durability and feeling of transparency, by partially replacing a calcium component of crystallized glass of calcium phosphate type with magnesium to give a specific composition. CONSTITUTION:The crystallized glass for dental material contains 40-75mol.% calculated as P2O5 of phosphorus oxide, 20-50mol.% calculated as CaO of calcium oxide and 2-20mol.% calculated as MgO of magnesium oxide. Further the glass may be optionally blended with 1-15mol.% calculated as Al2O3 of Al oxide, 1-15mol.% calculated as Ce2O3 of Ce oxide and 1-15mol.% calculated as La2O3 of La oxide. In the glass, when P2O5 is &lt;40mol.%, strength and transparency are low and when P2O5 exceeds 75mol.%, durability is low. When CaO is &lt;20mol.%, durability is low and when CaO exceeds 50mol.%, strength and transparency are low. When MgO is &lt;20mol.%, durability is low and when MgO exceeds 20mol.%, the glass becomes opaque.
NEW MATERIAL:The proteinous substance antitumor factor ATF (molecular weight, 45,000+ or -5,000; isoelectric point, 4.8+ or -0.3; strongly active to dissolve the mouse L-929 cell and kill &gt;=1/2 of the L-cell at a concentration of 500unit/ml within 48hr but inert to the fibroblast cell of normal human fetus, dermatic fibroblast cell of adult, and V-79 and DON cells, etc. of Chinese hamster, and has high tumor specificity; acidic protein containing sugar; deactivated with trypsin; partially deactivated by heating at 56 deg.C for 30min; etc.). USE:An antitumor agent. PREPARATION:In the cultured cell series of mammalian tumor calturable by subculture, only the histiocyte having phagocytic capability is cloned, proliferated in a medium containing bovine fetus serum, and cultured in a serum-free medium. The objective proteinous substance ATF can be separated from the supernatant liquid of the cultured product. When a BALB/c mouse belonging to the same system is affected with Me+n-A sarcoma, and is administered with &gt;=72 unit of ATF per head by intravenous injection, a hemorrhagic necrosis takes place in the tumor tissue.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a system for managing clinical history sheet capable of improving quality of medical care and improving service to a patient.  &lt;P&gt;SOLUTION: A reception counter 11 instructs a medical chart storage section 13 to retrieve an electronic medical chart of a patient to be re-examined from a request of the patient, and the electronic medical chart of the patient is transferred to an examination room 12 from the medical chart storage section 13. After a process, medication, doctor&#39;s questions, findings are described in the electronic medical chart in the examination room 12, treatment in a treatment room 17, inspection in a laboratory 18, and photography in an x-ray room 19 are instructed, and the electronic medical chart is transferred. After an examination result and a treatment result in the treatment room 17, the laboratory 18, and the x-ray room 19 are described, the electronic medical chart is transferred to the examination room 12. When medication is necessary, instruction for the medication is conducted to a pharmacy 15, and the electronic medical chart is transferred. Finally the electronic medical chart is transferred to the accounting counter 16 to settle an account and a receipt is calculated.  &lt;P&gt;COPYRIGHT: (C)2003,JPO
Keratinous fibres, e.g. wool, fur or especially human hair, are dyed by a process which comprises reducing some of the disulphide linkages of the cystine in the fibres to -SH groups while breaking hydrogen bonds by applying a suitable reducing agent, a hydrogen bond breaker for keratinous fibres and an aqueous solution of a water-soluble reactive dye.  The preferred dyestuffs contain vinyl sulphone, mono- and di-chlorotriazine or trichloropyrimidine groups (many listed). The specified reducing agents are thioglycollic acid (preferred), thiolactic acid thioglycerol, mercaptopropionic acid, sodium bisulphite, ammonium bisulphide, zinc or sodium formaldehyde sulphoxylate, sodium metabisulphite, potassium borohydride and hydroquinone and the specified hydrogen bond breakers are lithium bromide, urea, a mixture of lithium bromide and urea or resorcinol, catechol, dihydroxyacetone, formamide, potassium chloride and magnesium chloride.  The reducing agent and the hydrogen bond breaker may be applied before or together with the reactive dyestuff solution. In the case of the former a rinsing step may be included before the dyestuff solution is applied.  The aqueous compositions of the parent invention are usually of slightly alkaline reaction which may be achieved by the addition of ammonium hydroxide.  The compositions may also include the detergents: alkyl aryl sulphonates, sodium lauryl sulphate, triethanolamine lauryl sulphate, triethanolamine lauryl ether sulphate, alkanolamide fatty acid esters, polyoxyethylene fatty alcohol, polyhydric alcohol fatty acid esters, nonyephenoxy polyoxyethylene alcohols, soluble amine fatty acid soaps or soluble metallic fatty acid soaps as well as perfumes of the thickeners: guar, acacia and arabic gums, gelatin, polyvinyl alcohol, ethyl or methyl cellulose derivatives or alkylarylphenoxyethylene oxide condensates.  The present process may also be used for simultaneously &#34;permanent waving&#34; and dyeing human hair by employing known techniques combined with the present process. Examples are given. Specification 589,956 and U.S.A. Specification 2,564,722 are referred to.
PURPOSE:To obtain a granular agent for dental metal coating, by carrying out the calcination and pulverization process of the mixture of fine gold powder and porcelain component at a specific ratio, at least once, thereby equalizing the ratios of the gold and the additive in each fine particle to those of the raw material. CONSTITUTION:A mixture of 50-75wt% fine gold powder and at least one kind of porcelain component is calcined at a temperature lower than the melting point of the gold, and pulverized. The calcination and pulverization process is carried out at least once to obtain the objective fine granules for metal coat ing having a diameter of 20-50mum. The ratios of the gold and the porcelain component constituting each fine particle are made to be equal to the mixing ratios of the raw material by this process. The fine powder of gold is preferably particles having a diameter of &lt;=10mum. EFFECT:The metal cast surface is integrated to the metal coating agent, and the mechanical bonding force can be increased. USE:An agent for bonding a metal with a porcelain material in the preparation of a porcelain crown in dental work.
The present invention relates to methods and compositions for eliciting an immune response and the prevention and treatment of primary and metastatic neoplastic diseases and infectious diseases. The methods of the invention comprise administering a composition comprising an effective amount of a complex, in which the complex consists essentially of a heat shock protein (hsp) noncovalently bound to an antigenic molecule. Optionally, the methods further comprise administering antigen presenting cells sensitized with complexes of hsps noncovalently bound to an antigenic molecule. &#34;Antigenic molecule&#34; as used herein refers to the peptides with which the hsps are endogenously associated in vivo as well as exogenous antigens/immunogens (i.e., with which the hsps are not complexed in vivo) or antigenic/immunogenic fragments and derivatives thereof. In a preferred embodiment, the complex is autologous to the individual. In a specific embodiment; the effective amounts of the complex are in the range of 0.1 to 9.0 micrograms for complexes comprising hsp70, 5 to 49 micrograms for hsp90, and 0.1 to 9.0 micrograms for gp96.
PURPOSE:To provide an external agent for skin, composed of a specific ultraviolet absorber in combination with an oil having an iodine value of higher than a specific level, having improved compatibility to base, preventing the deterioration caused by the precipitation of crystals and having excellent ultravioletshielding effect and high quality. CONSTITUTION:The objective agent can be produced by adding an oil having an iodine value of &gt;=70 (e.g. drying oil such as linseed oil, nondrying oil such as sesame oil, fish oil such as sardine oil, etc.) to a dermatic agent for external use containing preferably 0.01-10% 4-(1,1-dimethylethyl)-4&#39;- methoxydibenzoylmethane as an ultraviolet absorber capable of absorbing sunlight, especially ultraviolet ray having relatively long wavelength and harmful to the skin (UV-A). the amount of the oil is &gt;=1/2 of the UV-absorber. The obtained external agent for skin has improved compatibility of the above UV- absorber to the base of the external agent and excellent ultraviolet-absorbing effect and quality and is storable stably for a long period with little deterioration.
The invention discloses a lung-heat clearing drink and a preparation method and application thereof, wherein the formula comprises 3-4 parts of fructus momordicae, 3-4 parts of lily, 2 parts of rhodiola rosea, 2 parts of fructus chebulae immaturus, 2 parts of lotus seed, 2 parts of cordate houttuynia and 1 part of peppermint. The prescription is mainly used for treating symptoms, and mainly comprises cough, shortness of breath, pharyngalgia, pharyngoxerosis, uncomfortable expectoration, dry mouth and bitter taste. Fang Zhongluo fructus Siraitiae Grosvenorii and fructus Canarii albi are monarch and slightly sweet in nature, and can dispel heat and clear lung, moisten throat and relieve sore throat, relieve cough and resolve phlegm. Lily is sweet and cold, can nourish yin and moisten lung, and has the effects of clearing heart fire and tranquillizing; rhodiola rosea Gan Hanwei is astringent and can tonify qi and lung. Lily is used as a ministerial drug for moistening lung, and rhodiola root is used for tonifying lung, so that the effect of clearing lung and relieving sore throat of monarch drugs is better. The lotus seed is sweet and astringent in taste, can tonify spleen, replenish kidney and arrest spontaneous emission, astringe lung and relieve cough and tranquilize mind, and is an adjuvant drug through the purgation of &#39; earth &#39; to generate gold &#39;. Yu xing Cao enters lung meridian and is cold in flavor and cool in nature, and helps to clear lung heat. Mint, herba Menthae, pungent and cool, can promote the flow of qi through the throat. The combination of the herbs can clear heat and moisten lung, and treat the joint with rights and generate body fluid.
PROBLEM TO BE SOLVED: To obtain a rice bran-derived composition for beautiful skin protecting the skin from pigmentation such as dermal stains, dullness and ephelides and suppressing aging of the skin. SOLUTION: This composition for the beautiful skin is characterized as comprising an extract from rice bran with a polar solvent. The composition having preventing actions on skin aging is the extract from the rice bran with the polar solvent and is characterized as comprising the extract composed of a high-molecular fraction having about 30,000-40,000 molecular weight. The composition for the beautiful skin having bleaching actions is the extract from the rice bran with the polar solvent and is characterized as comprising the extract composed of the high-molecular fraction having &lt;=50,000 molecular weight. A raw bran, a defatted rice bran or a fermented rice bran is preferably used as the rice bran. The skin care preparation, food and drink or chemical is characterized as comprising the composition for the beautiful skin.