anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PURPOSE:To produce the titled novel compound resistant to hydrolysis and having excellent stability, by copolymerizing a vinyl monomer to a vinylspiropyran derivative prepared from chloromethyl-substituted salicylaldehyde by a specific process. CONSTITUTION:The chloromethyl-substituted salicylaldehyde of formula I or formula II (R&lt;1&gt; is H, nitro, etc.) is made to react with triphenyl phosphite, and the resultant phosphonium salt is made to react with excess formaldehyde in the presence of an alkali to obtain a vinylsalicylaldehyde derivative. The objective copolymer of formula V or Vi (M is vinyl monomer unit; m and n are positive integer) can be produced by reacting the above derivative with the quaternary iodide of formula III (R2 is H, halogen, etc.) (e.g. substituted indolium iodide) and copolymerizing the obtained vinylspiropyran derivative with a vinyl monomer.
The invention relates to the preparing method and application of the total triterpene extracts from American solidago decurense. The total triterpene glycosides in the total triterpene extracts include Solidago decurense saponin 1,2,3 and 4, which can prevent and/or treat esophageal cancer, senile dementia, respiratory tract disease caused by different kinds of inflammation such as laryngopharyngitis and tracheitis. The diseases mentioned has been the main pathogeny that influences the quality of human life. The preparing technology of the extract is very simple, the extracting efficiency is very high; the extracts have strong pharmacologic action, stable quality and controllable quality; it&#39;s safe with less toxicity. The American Solidago decurense has damaged Chinese natural resources and ecological environment seriously as foreign invasive plant, it has been removed as weeds in many places. The invention can change waste into treasure while providing a new medicine source for preventing, diagnosing, detecting, protecting, treating and researching the mentioned diseases.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a skin activity promoter that is inexpensive and easy to use and achieves considerable effects.  &lt;P&gt;SOLUTION: The skin activity promoter comprises a broth without no other additives as it is obtained by extraction from leaves of Bambusa glaucescens by boiling with water. A very small amount of a perfume or the like may be added thereto. The thus-obtained promoter is put into a container and is sold. The promoter is applied by pouring into a bath like a bathing agent or directly sprinkling as it is on the skin. Leaves of Bambusa glaucescens are most desirable as the leaves used for the promoter but leaves of other kinds of bamboos can be used. Thus, the skin activity-promoting effects of bamboo leaves, particularly leaves of Bambusa glaucescens are utilized to the maximum by a simple method. The skin activity promoter is inexpensive and easy to use and achieves notable effects.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
Methods, systems, and apparatus, including computer programs encoded on computer storage media for determining a color pigment mixing recommendation based on a sensor reading of a person&#39;s skin. One or more color value sets of a person&#39;s skin are determined. The one or more color value sets are evaluated. A color pigment mixing recommendation is generated. The color pigment mixing recommendation including one or more color pigments and an amount of the color pigments to be mixed. The color pigment mixing recommendation is displayed, via a user interface of a client device, the color pigment mixing recommendation.
558,470. Linings for dentures. KINNEAR, R. A., DAVISON, J. W., and IMPERIAL CHEMICAL INDUSTRIES, Ltd. July 3, 1942, No. 9196. [Class 81 (ii)] Dentures are provided during fabrication, or subsequent to fabrication, with a resilient lining comprising a plasticised polymer or interpolymer of vinyl chloride containing between 20 and 70 per cent of a plasticiser which is preferably dibutyl phthalate. The plasticised polymer or interpolymer of vinyl chloride may be applied as a film or by deposition on the denture from a solution or aquaeous emulsion, but, in the preferred process, a plasticised polyvinyl chloride paste is used. Preferred interpolymers are obtained from organic compounds which contain the group CH&lt;SP&gt;2&lt;/SP&gt;=C&lt;, e.g. vinyl acetate, methacrylic esters and styrene, such organic compound constituting not more than 20 per cent by weight of the polyerisable mixture. In an example, a waxed-up model of a full denture was invested to the gum margin in white plaster in a flask and the wax removed by boiling water. The plaster model on which the wax denture was built was then coated with five layers of tin 9.003 inches thick. The other half of the plaster mould was coated with 1 part of water glass in 1 part of water, and allowed to dry. The mould was then packed with a monomer/polymer dough prepared from &#34;Kallodent&#34; 222 (Registered Trade Mark), the two halves of the flask being separated by sheets of &#34;Cellophane&#34; (Registered Trade Mark) during trial closures. When the mould was completely filled with dough, the excess was cut away, the cellophane and tin foil removed and the plaster model coated with sodium silicate solution and allowed to dry. A thick paste comprising 60 parts of polyvinyl chloride and 40 parts of dibutyl phthalate was then spread on the surface of the dough, the flask partially closed, clamped and pressed until fully closed. The clamped flask was then immersed in water at 30‹C. brought to boiling temperature in 20 minutes and left therein for 40 minutes. After cooling slowly to room temperature, the denture was deflasked and the lining trimmed with a sharp blade. In a further example, the lining was applied as a self-sustaining film of 45:55 polyvinyl chloride/dibutyl phthalate composition to the Kallodent dough in the flask prior to polymerisation. Specification 500,298, [Group IV], is referred to.
&lt;P&gt;PROBLEM TO BE SOLVED: To efficiently execute medical service by an electronic medical chart method without using wasteful paper for a temporarily necessary document so as not to increase trash.  &lt;P&gt;SOLUTION: This electronic medical chart system uses electronic paper 10 rewritable plural times, capable of holding contents of electronically displayed information without electric power. In a medical institution, a computer executing management of a patient information database of a patient&#39;s case history, a medical treatment record or the like, or a service process of a receipt or the like is connected with a writing device 4 for writing the information into the electronic paper 10, the information about a patient having a medical examination is written into the electronic paper 10, and a medical worker executes the service while looking at the electronic paper 10. The temporarily necessary personal information or medical treatment information is written into the electronic paper 10 for use. Because the electronic paper 10 can be rewritten into the next information and be reused when the information becomes unnecessary, the trash of the wasteful paper is not generated.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
FIELD: medicine; gastroenterology. SUBSTANCE: patient&#39;s stomach subjected to lavage through duodenal probe using irrigating fluid containing medicinal agents. Probe comprises hollow olive having 16 openings with 1 mm dia. Openings are uniformly scattered all over olive surface. Duodenal probe olive accommodates concave plate occupying 2/3 of olive lumen and arranged do that concavity apex faces tube. Next stomach mucosa is irrigated with fluid having temperature 39-40 C and fed under pressure 40 mm Hg, irrigation being effected daily for 7-10 days. EFFECT: effective treatment for erosive gastritis cases. 1 tbl
&lt;P&gt;PROBLEM TO BE SOLVED: To treat cerebral aneurysm by using wound healing by the inflammatory response of a cell.  &lt;P&gt;SOLUTION: A separable coil includes biocompatible and biodegradable polymers and has a function of stimulating the cell, causing the inflammatory response which is controlled by the cell, and promoting the wound healing. The coil is arranged at a body part with the cerebral aneurysm to be treated through the use of a catheter which is separably connected to the coil. Polyglygolic acid, a polyglygolic acid/poly-L-lactic acid interpolymer, polycaprolactive, polyhydroxy butylate/hydroxy valerate interpolymer, poly-L-lactide, polydioxanone, polycarbonate, and polyanhydride are suitable for the polymers. The coil can be constituted by partially containing growth factors such as a vascular endothelial cell growth factor or a basic fibroblast growth factor.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
PURPOSE:To provide a novel protoplast hybrid cell having the drug component (antitumor active component) of Fomes japonicus and the proliferability and edibility of Pleurotus octreatus, and obtained by the cell fusion of Fomes japonicus and Pleurotus octreatus. CONSTITUTION:The pieces of the tissue of fruit body of Fomes japonicus and Pleurotus octreatus are implanted aseptically in Hamad&#39;s culture base for Armillaria edodes to effect the growth of mycelia. The mycelia are proliferated, transplanted in Hamada&#39;s liquid media for Armillaria edodes, subcultured, and treated with an enzyme liquid to separate the protoplast of respective fungi. The separated protoplast is filtered with a filter, and centrifuged at 700xg. The residue is added with 0.5-0.7M aqueous solution of NaCl, and the dispersion and centrifugal separation procedures are repeated three times. The protoplast suspensions prepared by the above process are mixed together and centrifuged. The residue is dispersed in 30% PEG solution at 30 deg.C, cultured, added with a sufficient amount of an aqueous solution of NaCl, and centrifuged to obtain the hybrid cell of Fomes japonicus and Pleurotus octreatus.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a hair cosmetic composition whose foamability can easily be enhanced, and to provide a hair cosmetic article.  &lt;P&gt;SOLUTION: The oxidizing hair-dyeing agent is processed into a foamy agent form, when used, and is applied to hair in the foamy agent form. The hair-dyeing article includes the oxidizing hair-dyeing agent 10 and a closable container 20. The oxidizing hair-dyeing agent 10 contains an amphoteric surfactant, and is shaken to give a foamed foamy agent form. The closable container 20 is shaken to perform a foaming operation.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
Non- familial late-onset Alzheimer&#39;s disease (LOAD), a condition associated with the accumulation of the amyloid precursor protein-derived (APP) Αβ fragment in the brain, can be the consequence of combined genetic and environmental risk factors. One of these risk factors is the presence of the apolipoprotein ε4 (APOE4) allele. Human induced neurons (hiNs) are generated by directed conversion of skin fibroblast cells from APOE4 carriers and non-carriers. hiNs carrying an APOE4 allele display APP processing and endosomal trafficking defects relative to hiNs not carrying the APOE4 allele. An antibody selective for APOE4 or excess APOE3 protein, a lower-risk variant of APOE, prevents these defects. This invention provides for a human neuron model of an APOE4-induced pre-LOAD state. This invention further provides for a neuron model that can be used to screen and identify compounds that can prevent the APOE4-induced pre-LOAD state. This invention provides for methods for the treatment and/or prevention of a neurodegenerative disorder by using an inhibitor of APOE4, such as an antibody inhibitor, or by using an excess of APOE3 protein.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a therapeutic agent for arthralgia for external use that is not sticky and excellent in analgesic effects and heating effects (persistency).  &lt;P&gt;SOLUTION: The therapeutic agent for arthralgia for external use comprises a non-steroid antiinflammatory agent and, incorporated therewith, nonanoic acids, a cool feeling-imparting component, powders, a thickening agent and a polyhydric alcohol, where the amount of the powders is 0.3-1.2 pts.wt. based on 1 pt.wt. of the polyhydric alcohol. The therapeutic agent for arthralgia for external use exhibits, in particular, both inflammation-soothing effects and blood circulation-facilitating effects, improves metabolism in an affected part and promises to exhibit tissue-restoring effects.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
The invention relates to the technical field of a traditional Chinese medicine preparation, and discloses a traditional Chinese medicine enema for treating exogenous fever of infants. The enema is prepared by taking radix scutellariae, honeysuckle, forsythia, dandelion, gypsum and rhizoma anemarrhenae as raw materials through the steps of soaking, decocting and filtering. The invention is characterized in that each dose of enema is prepared from the following raw materials in proportioning by weight: 2-5g of radix scutellariae, 5-8g of honeysuckle, 2-5g of forsythia, 5-8g of dandelion, 9-12g of gypsum and 2-5g of rhizoma anemarrhenae. The enema has the functions of clearing away heat and toxic material, diminishing inflammation and allaying the fever, and is a preferred medicament for allaying the exogenous fever of infants. Compared with the existing treatment method, the enema disclosed by the invention can be quickly absorbed through rectal administration, has a good treatment effect, reduces the &#39;first pass effect&#39; of general medicaments, has high bioavailability and low price, is convenient and easy to implement, does not have toxic side effects, has an obvious effect on allaying the fever, and also solves the problem that infants are afraid of needles and medicaments. Observed by 200 clinical cases, the antipyretic effective rate within 36 hours is 100%.
In the crystallization of insulin from aqueous solution the size of the resulting crystals is controlled by adding a predetermined quantity of insulin seed crystals of a predetermined size. Spontaneous crystallization may be suppressed as far as possible or slight spontaneous crystallization may be allowed.ALSO:A process of crystallizing insulin from an aqueous medium of pH 5 to 7 in the presence of a crystallization-promoting metal e.g. zinc, cobalt, nickel, cadmium, copper, iron, or manganese, comprises seeding the medium with insulin crystals in an amount given by the equation &lt;FORM:0766995/VI/1&gt; where P is the weight in grams of seed crystals used, I is the weight in grams of insulin to be crystallized, and dp and di are the greatest size and the desired upper limit for size in micron of the seed crystals and crystallized insulin respectively. The size of the crystal is defined as the length in micron of the longest diagonal of the crystal.  Crystals of uniform size are obtained by preventing spontaneous crystallization e.g. by addition of a buffer substance the anion of which does not bind the crystallization-promoting metal at neutral reaction, and by the use of seed crystals of mainly the same size.  Suitable buffers are borate, diethylbarbiturate, maleate or acetate buffers. Crystallization may take place in the presence of halogen in ionic form e.g. as the halide of ammonia, alkali or alkaline earth metals, or mixtures thereof, in a concentration above 0.2 mole per litre, as in Specification 733,740 in which case phosphate or citrate buffers may be used.  A basic or acidic solution of insulin which may or may not contain the required content of metals, may be adjusted to the crystallization pH by means of a buffer; the insulin may be precipitated amorphously and subsequently changed into crystalline form by the addition of seed crystals together with the necessary metals, e.g. as an aqueous solution of the metal salt or by the addition of the seed crystals which may themselves exhibit sufficient metal content. The seed crystals may be formed by the process of Specification 766,994 and may be added in the form of an aqueous suspension or in dry freeze dried form.  An injectable insulin preparation may be prepared in conjunction with the process of Specification 709,927.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a highly safe and naturally occurring antioxidizing substance having an excellent active oxygen scavenging ability.  &lt;P&gt;SOLUTION: It is shown for the first time that citrulline has an active oxygen scavenging ability. A new active oxygen scavenger comprising the citrulline as an active ingredient has the excellent active oxygen scavenging ability and is characterized as being highly safe. Thereby, a therapeutic agent or a prophylactic agent for diseases caused by active oxygen injury and comprising the citrulline as an active ingredient and an antioxidizing food additive comprising the citrulline as the active ingredient are provided. Furthermore, the citrulline has actions of protecting a DNA from the active oxygen injury, and a DNA cleavage preventive agent comprising the citrulline as the active ingredient is provided.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
The utility model relates to a tooth paste, including a soft plastic film and a base (1). A jelly with medicament is overlaid on one side of the soft plastic film. The side of the soft plastic film is laminated onto the base (1). A crack (6) is cut on the soft plastic film, dividing the soft film into two parts: main pasting film (4) and the anti-overflow part outside the main pasting film (3). The soft plastic film is divided into two parts: the main pasting film and the anti-overflow part outside the main pasting film. The main pasting film is the effective part. The overflow part of the jelly would not do any affect onto the main pasting film and the effective content would not be lost. What&#39;s more, the jelly overflowing from the cutting crack would make up for the soft plastic film from two sides of the crack. The medicament dosage on the edge of the main pasting film can be effectively ensured.
The invention which is named as &#34;fritillary and snow pear particle and preparation method thereof&#34; belongs to the technical field of composite traditional Chinese medicines. The fritillary and snow pear particle can mainly solve problems shown in the specification. The main characteristic of the fritillary and snow pear particle is that bulk drugs of a particulate agent (the particle) comprise 100-300 parts of a clear pear paste, 15-40 parts of Fritillaria cirrhosa, and 30-80 parts of Ophiopogon root. The preparation method comprises the following steps: preparing fresh pear into the clear pear paste with the relative density of 1.20-1.38; preparing Fritillaria cirrhosa into a percolate; decocting Ophiopogon root, lily, and tussilago, taking a supernatant, concentrating to a proper amount, adding the Fritillaria cirrhosa percolate and the clear pear paste, concentrating to a new clear paste (a stiff paste) with the relative density of 1.25-1.38; and preparing into the particle by taking 1-1.5 parts of the stiff paste, and adding 2-4.5 parts of sucrose, and 1-1.5 parts of dextrin. The fritillary and snow pear particle has the efficacies of lung moistening and cough relieving, and body fluid generating and throat disinhibiting. The particle of the present which has the characteristics of good cough relieving effect, accurate usage amount, and difficult bacterial contamination is mainly used in the fritillary and snow pear particulate agent for treating yin deficiency and lung heat, cough, tachypnea, and mouth and throat dryness and the preparation method of the particulate agent.
The present invention provides novel biomaterials comprising one or more of Mg, Zn and F ions in a carbonate-containing biphasic calcium phosphate (BCP) system. The biomaterial may contain Mg, Zn, F, Mg and Zn, Mg and F, Zn and F, or Mg, Zn and F. The biomaterial may be substantially similar in composition to bone mineral (a carbonate apatite). The biomaterial may feature slow release of Mg, Zn, F, Ca, and P ions. The biphasic calcium phosphate, BCP, may be a mixture of unsubstituted hydroxyapatite (HA) and unsubstituted.-TCP, Ca 3 (PO 4 ) 2 . BCP of varying HA/.-TCP ratios may be produced by sintering calcium-deficient apatite, for instance having a Ca/P&lt;1.5, 1.6, 1.67, 1.75 or 1.8 that has been prepared either by a precipitation or by a hydrolysis method or by a solid-state reaction. The amount of each component (by weight %) present in the biomaterials may be as follows: Mg 0.5 to 12 wt %, Zn 1 to 12 wt %, F 0.1 to 4 wt %, calcium 20 to 40 wt %, phosphate 10 to 20 wt %, and carbonate (CO 3 ) 1 to 20 wt %. The biomaterial may further comprise one or more other ion such as strontium, manganese, copper, boron or silicate, or one or more other organic moiety such as a protein, a peptide, or a nutraceutical which may provide antioxidant, anti-bacterial or anti-inflammatory properties. The invention also provides methods of inhibiting bone resorption, methods of treating osteoporosis or delaying the onset of osteoporosis, methods of treating a bone fracture, and methods of inhibiting osteoclast activity. Further, the invention provides methods of treating or reversing bone deficiencies such as bone loss, similar to osteoporosis, caused all or in part by a mineral deficient diet, a disease such as cancer or osteopenia, a treatment such as steroid therapy or radiation therapy, or a physical condition such as immobilization.
A glandular extract for subcutaneous injection in treating carcinoma, sarcoma, &amp;c., is prepared from the isolated cortical portion of suprarenal glands by means of a solvent, such as water, which is non-irritating to normal body tissue.  The glands are separated from fat and adhering tissue, placed for 3-4 minutes in a normal saline solution, then cut from pole to pole.  The medullary portion is dissected away with the inner third of the cortex.  The remainder of the cortex with the envelope, is macerated with 2 1/2 volumes of water, and the temperature gradually raised to 85 DEG  C. and then reduced to 65 DEG  C.  The mixture is slightly acidified with hydrochloric, acetic, or other acid, allowed to cool to 55 DEG  C. and strained into 95 per cent alcohol. A further quantity of alcohol is added to precipitate colloidal and other matter and after standing at room temperature the clear liquid is decanted and filtered. Filtration is repeated at intervals, and the alcohol is then distilled off, leaving an aqueous solution which is allowed to stand and filtered.  A preservative such as thymol or tricresol may be added, and the extract bottled for storage.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an implantable medical device, which can be coated to minimize a biological organism&#39;s reaction to an introduction of the medical device to the organism.  &lt;P&gt;SOLUTION: The medical device can be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds are mixed with the biocompatible materials. When the therapeutic agents are delivered to a region of a disease site, liquid formulations is desirable to increase efficacy and deliverability of the particular drug. The medical device includes various stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT