anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
The invention discloses an oral miracle drug, in particular to a concretion decomposing powdered medicine, belonging to a Chinese medicine preparation in curing renal calculus, capable of decomposing a solid renal calculus into liquid state and being discharged out of a human body with emiction successfully, indolence, and curing the diease completely in a short curative effect. The medicine is characterized in: the endothelium corneum gigeriae galli, Glauber&#39;s salt, climbing fern spore, rhizome dioscoreae hypoglaucae, turtleback and buffalo horn are mixed together and be made into powdereds or troches by being comminuted. The formula is bitter and cold, wherein the endothelium corneum gigeriae galli and climbing fern spore are capable of decomposing concretions and dredging emiction, the rhizome dioscoreae hypoglaucae, Glauber&#39;s salt and buffalo horn are capable of separating limpidity from turbidity, removing heat and damp, removing blood-heat and stopping bleeding, with all the medicine components working together, all kinds of concretion is capable of being decomposed into liquid state in immateriality and be drainaged successfully till all symptoms disappear. The turtleback in the formula is capable of nourishing Yin and Yang, invigorating the kidney, strengthening bones to prevent too much drainaging. Treating and nourishing are both used to work together in decomposing concretions, with an effect of benefiting for circulation and emiction. The beneficial effect is: indolence, fast curative effect and complete curing.
PROBLEM TO BE SOLVED: To obtain the subject composition usable by massage through taking it on one&#39;s hand without any tool and useful as a cleansing agent composition especially for the body by designing the composition to have a specific viscosity and specific pseudoplasticity. SOLUTION: This composition is such as to have a viscosity with the number of revolutions of 0.5 s-1 at 30 deg.C as 800-20,000 mPa.s, and the ratio of viscosity η1 with the number of revolutions of 0.1 s-1 to viscosity η2 with the number of revolutions of 1 s-1 (η1 to η2) as &gt;=3. The above viscosity and pseudoplasticity can be realized, for instance, by formulating a surfactant-containing liquid such as of a polyoxyethylene alkyl ether sulfate salt with a thickening agent capable of imparting pseudoplasticity (e.g. an alkyl acrylate/methacrylate copolymer). It is preferable to include e.g. powder, particles, beads in this composition.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a cleansing cosmetic which exhibits a transparent liquid state, has excellent cleansing power and causes neither reduction in cleansing power nor deterioration of appearance and sense of use even in the case of application to the wet skin.  &lt;P&gt;SOLUTION: The transparent liquid cleansing cosmetic is a composition comprising (A) a 12-18C fatty acid residue-containing monoglycerol fatty acid ester, (B) a 12-18C fatty acid residue-containing polyglycerol fatty acid ester, (C) a water-soluble nonionic surfactant except the component (A) and the component (C), (D) an oily component liquid at 25°C and (E) 1-12 wt.% of water in the weight ratio of the component A: the component (B) of 20:80-80:20 and causes no white turbidity when 50 parts wt. of water is added to 100 parts wt. of the composition. The cleansing cosmetic has excellent sense of use and excellent storage stability at a low temperature, is usable for the skin wet with water and is suitably useful especially in a bathroom.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
The invention provides a special wet tissue for blowing one&#39;s nose. The wet tissue is composed of a carrier and preparations attached onto the carrier. The wet tissue is characterized in that the preparations comprise ethylene diamine tetraacetic acid, xanthan gum, PEG-40 or hydrogenated castor oil, dimethyl silicone polymer, Dermasoft LP, citric acid, sodium citrate, NaCl, aloe extract, honeysuckle extract, and the balance water. The invention also protects a preparation method of the wet tissue. The wet tissue is free from preservatives, is advantaged by environmental protection, hygiene and safety. The wet tissue can wipe off snot, mucus or the like. The wet tissue is advantaged by sterilization and bacteriostasis, can prevent the red and swollen symptom or the like caused by repeated wiping, and is suitable for any people.
The method of event-driven health and wellness decision support considers an individual&#39;s medical records and lifestyle; applies healthcare best practices; and recommends next steps. Medical and lifestyle records are input, converted to events and inserted in timestamp order in an event queue. Events are processed in queued order by handlers, and results recorded in a data structure called a “person state”. Some handlers create additional events and insert them in the event queue in timestamp order. Those events are in turn processed in timestamp order. Other handlers create no events, allowing processing of all queued events to eventually complete. After events representing actual occurrences are processed, events representing postulated activities are created, queued, and processed until a specific patient state representing a health and wellness goal obtains. This allows several activity paths to be compared to determine the best path to an optimal health goal. Next steps are recommended as output.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a highly bioadherent cultured periodontal ligament cell sheet having good adherence to the dental root surface.  &lt;P&gt;SOLUTION: The cultured periodontal ligament cell sheet is produced by a process comprising culturing cells on a cell culture support composed of a base material whose surface is coated with a temperature-responsive polymer having an upper limit or lower limit critical dissolution temperature in water of 0 to 80°C. under specified conditions, (1) regulating the temperature of a culture fluid to the upper limit critical dissolution temperature or higher or to the lower limit critical temperature or lower, (2) allowing a cultured periodontal ligament cell sheet resulting from the culturing to adhere to a carrier and (3) detaching the sheet intact together with the carrier. This cultured periodontal ligament cell sheet has a syndesmotic microstructure, exhibits extremely high bioadherence to the dental root surface and achieves high density transplantation of target cells and positive reconstruction of periodontal tissues. Moreover, through lamination of cell sheets to be transplanted and donation of a three-dimensional polarity, highly efficient reconstruction of an adhesion apparatus can be accomplished and clinical application thereof to moderate periodontitis, severe peridontitis, gingival recession and the like is highly promising.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
The invention discloses a disease analysis system based on daily voice data, which can detect various nervous system diseases simultaneously. The system utilizes the user&#39;s daily speech data in conjunction with audio MFCC features in a two-stage multi-classification module to construct an accurate speech-based disease prediction model. The first stage captures fine-grained details of these diseases and their sequential patterns of change in health discrimination module for basic disease detection, i.e. health and non-health. In the second stage, the detected pathological samples are further analyzed by a disease diagnostic module to identify the disease type. The system can detect various diseases simultaneously, and has high detection efficiency and convenient use.
PROBLEM TO BE SOLVED: To obtain a ceramics capable of freely controlling its particle size or pore diameter, excellent in carrying property for a medicine, affinity to a live body, sustained release property for a medicine and absorption property for live body and useful as a bone filler and a sustained release carrier for medicine by dropping a ceramic material onto a low temp. medium to freeze-dry the material and then sintering. SOLUTION: The ceramics consisting preferably of calcium phosphate, more preferably of hydroxyapatite, tricalcium phosphate, calcium secondary phosphate, tetracalcium phosphate, octacalcium phosphate or the mixture thereof is pulverized, for example, preferably to &lt;=100μm particle size. Then the ceramic material is mixed with a binder slurry (such as PVA soln.) and dropped onto a low temp. medium (such as liquid nitrogen) to freeze while its spherical shape is maintained. The frozen material is dried to remove the water content while preventing defrosting, and further sintered at 800 to 1,500 deg.C, preferably 1,000 to 1,400 deg.C.
The present invention discloses a new class of highly fluorescent indicator dyes that are specific for calcium ions. The new fluorescent indicator dyes combine a stilbene-type fluorophore with a tetracarboxylate parent Ca2+ chelating compound having the octacoordinate pattern of liganding groups characteristic of EGTA and BAPTA. Preferred forms contain extra heterocyclic bridges to reinforce the ethylenic bond of the stilbene and to reduce hydrophobicity. Compared to their widely used predecessor, &#34;quin2&#34;, the new dyes offer up to thirty-fold brighter fluorescence, major changes in wavelength (not just intensity) upon Ca2+ binding, slightly lower affinities for Ca2+, slightly longer wavelengths of excitation, and considerably improved selectivity for Ca2+ over other divalent cations. These properties, particularly the wavelength sensitivity to Ca2+, make the dyes useful indicators for many intracellular applications, especially in single cells, adherent cell layers, or bulk tissues. The present invention also discloses an improved method for synthesizing alpha-acyloxyalkyl bromides wherein the bromides so synthesized are free of contaminating bis(1-bromoalkyl)ether. The improved method is exemplified herein in the synthesis of acetoxymethyl bromide, a compound useful in preparing the acetoxymethyl esters disclosed herein as novel Ca2+ specific fluorescent indicators.
PURPOSE: A pharmaceutical formulation containing 2-hydroxy benzoic acid derivatives is provided to ensure safety and to effectively prevent or treat cell injury and inflammatory diseases. CONSTITUTION: A pharmaceutical composition for treating or preventing inflammatory disease contains 2-hydroxy benzoic acid derivatives of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. The inflammatory diseases are inflammatory pain, nephritis, hepatitis, Alzheimer disease, or Parkinson&#39;s disease. The pharmaceutical composition is manufactured in the solid formulation or liquid formulation. The solid formulation includes powders, granules, tablets, capsules, and suppositories. The liquid formulation includes water, solutions such as propylene glycol solution, suspension, and emulsion.
One embodiment of the present invention relates to a system for obtaining real time financial information utilizing a bar code or RF ID reader on a handheld device. A bar code or RF ID reader is used to obtain the product identity of a particular product in a retail environment. The product identity is correlated with the particular retailer&#39;s product price. This information can then be analyzed versus current financial budgets or recorded as part of a financial plan. In addition, real time financial advice and information can be given on the product including whether a competitor offers a lower price on a similar product, consumer reviews of the product, value rating, etc. The bar code or RF ID reader may be incorporated into any existing handheld device including a PDA, media player, cell phone, calculator, watch, or shopping device.
A two-stage medicine delivery system provides an initial dose of medicine and a second dose of medicine. The initial and second doses are capable of achieving a rapid pharmacological effect and a prolonged pharmacological effect, respectively. The two-stage medicine delivery system preferably delivers a craving reduction substance, in which case, the rapid and prolonged pharmacological effects include a rapid and prolonged craving reduction. Preferably, the delivery system is a nicotine delivery system which is provided in chewing gum form or lozenge form and which provides the nicotine in a transmucosally absorbable form. The two-stage medicine delivery system preferably releases a buffering agent which increases a pH level in a user&#39;s mouth to facilitate absorption of the medicine when the delivery system is placed in the user&#39;s mouth. A method of making the medicine delivery system also is provided. The system and apparatus can be adapted to reduce cravings for alcohol, food, drugs (e.g., cocaine, opiates and the like) and tobacco products, especially tobacco products containing nicotine.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a sustained-release carrier that is derived from a naturally occurring substance, has a film-forming property and exerts excellent water retention even in the presence of a salt, a drug using the sustained-release carrier, and a drug delivery system using the drug.  &lt;P&gt;SOLUTION: The sustained-release carrier is prepared by dissolving sacran derived from Aphanothece sacrum in water or a solvent containing water, and adding a trivalent cation to the resulting solution so as to form gel. The drug can be carried by the resulting gel. The drug is prepared using the sustained-release carrier. In the drug delivery system, the amount of the drug released can be adjusted by first administering the drug to a living body and subsequently administering a preparation containing a chelating agent, a trivalent cation or an enzyme that cleaves a sugar chain in sacran so as to act on the sacran gel.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;amp;INPIT
A microRNA (miRNA) inhibitor, being able to form a stable DNA-RNA double-stranded structure with a miRNA. The double-stranded structure comprises: (i) a miRNA unit sequence, and (ii) an RNA zipper unit sequence. The 5&#39;-end of the RNA zipper unit sequence is connected to the 5&#39;-end of the miRNA unit sequence. The 3&#39;-end of the RNA zipper unit sequence is connected to the 3&#39;-end of the miRNA unit sequence. The RNA zipper can connect the head of the miRNA molecule to the tail of the miRNA molecule to form a stable long-chain structure. The RNA zipper unit sequence contains 1-3 nucleotides not connected to the miRNA unit sequence. The DNA-RNA double-stranded structure can be used to inhibit biological activities of a miRNA unit, does not have biological toxicity, and has the advantages of high affinity, high specificity and high stability.
FIELD: organic chemistry, vitamins. SUBSTANCE: invention describes the novel analogs of vitamin D of the general formula (I)   where values  , X, Y, Y&#39; are given in p. 1 of the invention claim. Compounds show selective activity with respect to cellular functions. Invention describes also method of their synthesis and pharmaceutical composition based on compounds of the formula (I). EFFECT: improved method of synthesis. 24 cl, 16 dwg, 3 tbl
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a receptor that can be produced easily and used advantageously for pharmaceutical or diagnostic applications, and to provide applications thereof.  &lt;P&gt;SOLUTION: Recombinant soluble Fc receptors include no transmembrane domains, signal peptides or glycosylation. Such Fc receptors can easily be obtained by expressing respective nucleic acids in prokaryotic host cells and renaturation of the obtained inclusion bodies, which procedure leads to very homogenous and pure products. The products can be used for diagnostic as well as pharmaceutical applications and also for the generation of crystal structure data. Such crystal structure data can be used for the modeling of artificial molecules. A further embodiment includes coupling of the Fc receptors to solid-state materials like chromatography materials that can be used to separate and/or enrich antibodies.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To obtain an agent performing actions of stimulating the synthesis of collagen, reducing a sign of skin aging, stimulating the astringency of the skin and/or mucous membrane, etc., by formulation thereof with a cosmetic by using cinnamic acid (derivative). SOLUTION: This agent for reducing a sign of aging of skin by application thereof to a cosmetic is composed of cinnamic acid (derivative). The cinnamic acid is present in the trans-form in an essential oil of a cocoa leaf, Peruvian balsam and a cinnamon or a basil. The ci-form is present in an oil of Alpinia malacensis. For example, mono- and polyhydroxycinnamic acids or alcohols are cited as the cinnamic acid derivative. The cinnamic acid derivative may be a natural product of the one derived from synthesis however, the cinnamic acid is preferably used. The amount of the formulated cinammic acid is preferably 10&lt;-6&gt; to 10%, more preferably 10&lt;-3&gt; to 5% based on the total weight of the cosmetic.
The patent of invention of the hemodiluted stent utility with medicament metformin for prevention of intracoronary reestenose, is resumed in the combination of a endoprotese hemodiluted to a modulator of insulin resistance, utilized against the cardiovascular diseases that are the main cause of death in globalized world. The are neat correlation between the ponderal again and weight excess with risk of cardiovascular diseases. The weight excess predisposes to these illnesses due to abnormalities in the metabolism of lipides, glucose and arterial pressure. The insulin resistance/ hyperinsulinemia seems to be an independent risk factor of other associated risk factors, as the obesity, hyperlipidemia and hypertension, either in men or in women The insulin and the growth factors similar to insulin estimulate the activity of the smooth muscle cells and are involved the atherogenese and even in the reestenose that follow to the coronary repair by angioplasty. Other effects of the insulin are related to the mechanism that contribute for the development either from hypertension, miocardial hypertrophy, coagulation processes, dyslipidemia, contributing for the intracoronary reestenose pos implantation of endoprotese. The patent of invention of the hemodiluted stent utility with medicament metformin for prevention of intracoronary reestenose, diminishes sensitively this vascular dangers process, for, the union of the local vascular flux, and the modilators functions of resistance of hemodiluted medicament, that&#39;s the perfect combination, for the diminution of cardiovascular events myocardial infarction and death.
PROBLEM TO BE SOLVED: To obtain the coating powder resistant to the moisture-absorbing solidification and the evaporation of components in processing and storage and keeping the effect of a core substance over a long period in eating by coating a core substance exhibiting solid state at normal temperature with a powdery lipid having a melting point of &gt;=40 deg.C in the presence of a specific oil and fat. SOLUTION: A core substance which is solid at normal temperature (e.g. perfume, acidulant, vitamin, etc., taking crystalline or powdery state at normal temperature) is coated with a powdery lipid having a melting point of preferably &gt;=40 deg.C (preferably a hardened animal or vegetable oil such as hardened rapeseed oil) in the presence of a molten resin having a melting point of &gt;=40 deg.C (preferably 40-100 deg.C). Preferably the sum of the powdery lipid and the molten oil and fat is 0.1-5 pts.wt. based on 1 pt.wt. of the core substance and the amount of the molten oil and fat is 0.1-5 pts.wt. based on 1 pt.wt. of the powdery lipid. The particle size of the core substance is preferably 30-150 mesh and the particle diameter of the powdery lipid is preferably 10-100μm.  A flavor-improving effect having excellent quick and durable effect can be attained by adding a perfumery substance to the molten resin.
PROBLEM TO BE SOLVED: To obtain a composition for an oral cavity capable of preventing dental caries by neutralizing an acid produced in a dental plaque. SOLUTION: This composition for an oral cavity comprises fine calcium carbonate containing &gt;=50wt.% particles having a size of primary particles as a particle diameter within the range of 0.04-3μm. Since the calcium carbonate having the specific particle diameter is capable of reaching even a narrow site readily causing dental caries and is hardly soluble in water, the calcium carbonate easily stays in a dental plaque. Thereby, the neutralizing reaction is initiated only when an acid is produced in the dental plaque to prevent teeth from being decalcified. Calcium ions are released therefrom to promote the recalcification. The calcium carbonate is blended in an amount of especially preferably 1-30% based on the whole product due to the manifestation of high viscosity characteristics when the blended amount is too large.
FIELD: medicine, gastroenterology, pharmacy. SUBSTANCE: invention relates to a pharmaceutical composition for peroral administration and method of treatment of patients with enteric diseases. The proposed composition has 5- aminosalicylic acid as an active component that is adapted for modified release of drug from envelope in order to obtain clinically important localized effective pattern of 5-aminosalicylic acid by release of the required amount of 5-aminosalicylic acid in small and large intestine. Invention relates to also a method of treatment of patients with inflammatory enteric diseases of Crohn&#39;s disease type and ulcerative colitis also. Invention provides favorable release of drug in clinically required doses. The latter effect is provided by the following pattern: nonsignificant release of 5-aminosalicylic acid in stomach and its significant release in small and large intestine for the corresponding time. EFFECT: enhanced effectiveness of composition, improved method of treatment. 12 cl, 12 dwg
A real-time exercise feedback system of the present invention accurately measures a user&#39;s maximum oxygen intake and provides the user with the same, regardless of the altitude at which the user takes exercise. The real-time exercise feedback system comprises a wearable device and a server. The wearable device is worn on a part of the user&#39;s body to measure the user&#39;s body and the user&#39;s exercise status. The wearable device includes a sensor module, a control module, and an output module. The sensor module generates sensing data including the user&#39;s heart rate, a breathing rate, and motion information. The control module receives the sensing data and generates prescription data including an exercise intensity guide and a breathing control guide. The output module converts the prescription data into at least one of vibration, sound, and image forms and provides the user with the same.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an antitumor agent containing a fatty acid or its derivative having excellent antitumor activity, high safety and low side action as an active component and provide a food, drink and feed for antitumor use.  &lt;P&gt;SOLUTION: The antitumor agent and a food, drink or feed for antitumor use contains 9-trans-11-trans-conjugated linoleic acid as an active component. The 9-trans-11-trans-conjugated linoleic acid is used in the form of e.g. a fatty acid, its ester or metal salt, other pharmacologically permissible form or their mixture. The antitumor agent having antitumor action and a food, drink or feed for antitumor use contain the 9-trans-11-trans-conjugated linoleic acid.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI