anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PURPOSE: To provide a novel compd. which has an excellent pharmacological activity and is useful e.g. as a remedy for hypercalcemic diseases, Paget&#39;s diseases, etc., and as an inhibitor aganist ovulation or spermatogenesis.  
     CONSTITUTION: This compd. is an LHRH antagonist peptide having, in the form of being combined with amino groups, a sugar residue (A) and a residue of (B) formula I (wherein Y 1  and Y 2  are both H or either one is H and the other is OH; and f and g are each 0 or 1) or formula II or a physiologically tolerable ether or ester thereof (provided when the LHRH antagonist peptide has residue A, then this residue is an Amadori sugar residue attached by a coupling other than a direct N-glycosidic bond to an ω-amino group of an ω-amino-substd. side chain at the 8 position) in free form or in salt or complex form. An example is a compd. of formula III. The compd. having a residue of formula I is obtd. by reducively aminating a compd. of formula IV (wherein Z 4  is -CHO or the like) with a compd. of the formula: P-NH 2  (wherein P is an LHRH antagonist residue or the like) to give an isomer mixture and separating and recovering an optically active isomer from the isomer mixture. 
     COPYRIGHT: (C)1995,JPO
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a functional composition containing a functional substance exhibiting functionality, and having respondency to stimulation, to provide a method for forming images by using the same, and to provide a device for forming the images.  &lt;P&gt;SOLUTION: This functional composition contains a nonionic amphiphatic block copolymer, an ionic polymer, a functional substance comprising a colorant, and a solvent. Thus, the functional composition has the respondency to the stimulation. An ink composition for inkjet use is formed out of the functional composition. The method for forming the images comprises conducting recording by discharging ink from an ink discharge part and applying the discharged ink to a recording medium, wherein the ink composition is used as the ink. The device for forming the images uses the ink composition as the ink.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
PURPOSE:The titled pharmaceutical preparation having extremely improved dissolution properties of nifedipine, useful for remedying angina pectoris or hypertension, obtained by blending nifedipine with hydroxypropyl cellulose, followed by crushing them together. CONSTITUTION:The titled pharmaceutical preparation containing ultrafine composition obtained by crushing nifedipine [chemical name: 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester] in combination with hydroxypropyl cellulose in a mixed state. In a blending ratio of the composition, 1pt.wt. nifedipine is usually blended with &gt;=0.65pts.wt. hydroxypropyl cellulose in case of hydroxypropyl cellulose alone and they are preferably crushed. The composition has extremely improved dissolution properties, and shows no reduction in dissolution ratio in a long period preservation.
506,095. Vaccines and the like. CHEMICAL WORKS. April 26, 1938, No. 12467. Convention date, May 8, 1937. [Class 81 (i)] Material for inoculation purposes is prepared by freeing cultures of bacteria &amp;c. from water by exposure to a high vacuum at temperatures below 0 C. and killing the bacteria &amp;c. in the dry state by treatment with anhydrous cell poisons or radiations of short wave length. The cultures are frozen rapidly by immersion in a mixture of carbon dioxide and ether, or liquid air, and dried in a vacuum of less than 0À001 mm. of mercury. The dehydrated organisms are then killed by treatment with anhydrous cell poisons such as hydrocyanic acid, hydrogen sulphide, carbon disulphide or formaldehyde, or by ultra violet light, the process being carried out preferably in a solvent, for example benzene, xylene, halogenated hydrocarbons or ether. The product after being freed from solvent may be taken up in physiological salt solution or in a non-aqueous oil or fat, e.g. paraffin oil, olive oil, wool fat. Example 1. Staphylococci after freezing and drying are killed by a solution of hydrocyanic acid in benzene. The dry product is suspended in a mixture of anhydrous wool fat and olive oil. Example 2. Streptococci, after separation from a culture, freezing and drying, are killed by means of a solution of formaldehyde in benzene. The product is dispersed in physiological salt. solution containing a trace of pyridine. Example 3. Dehydrated tubercle bacilli are killed by extraction with carbon disulphide. Example 4. A culture of tubercle bacilli obtained by culture in a collodion sac inserted in the abdonimal cavity of a guinea pig is treated according to the method of example 2. Example 5. The brain of a fowl infected with fowl plague virus is rubbed to a paste and treated according to examples 1-3.
Dibutylaminoethyl ester of 4 - n - butylamino - 2 - hydroxy benzoic acid is prepared by heating a mixture of 4-n-butylamino-2-hydroxy-benzoic acid, p-toluene sulphonic acid and dibutylaminoethanol on a steam bath for 5 hours, making alkaline with potassium carbonate and extracting the ester so formed with ether. The hydrochloride is produced by dissolving the ester in hydrochloric acid.  Specifications 736,960 and 760,003 are referred to.ALSO:A pharmaceutical composition having activity against gram-negative bacteria, e.g. E. coli and B. proteus, comprises penicillin in admixture with a salt of an ester of general formula &lt;FORM:0790300/VI/1&gt; in which R1 and R2 are alkyl groups each containing 1 to 4 carbon atoms, X is hydrogen or a hydroxyl group, and R is an alkyl group containing 2 to 6 carbon atoms, the acid addition salt of the ester being present in an amount sufficient to increase the range of activity of the penicillin.  Esters specified are (a) dimethylaminoethyl ester of 4-n-butylamino-2-hydroxybenzoic acid; (b) diethylaminoethyl ester of 4 - n - butylamino - 2 - hydroxybenzoic acid; (c) dimethylaminoethyl ester of 4-n-butylamino-benzoic acid; and (d) dibutylaminoethyl ester of 4-n-butylamino-2-hydroxybenzoic acid. The hydrochloride is the preferred salt of these esters, but salts with tartaric acid, lactic acid or the sulphamic acid salt of p-aminosalicylic acid may be used. The penicillin may be any penicillin, penicillin G being preferred. The compositions may be used as aqueous solutions containing not more than 0.5 per cent of the ester salt.  Specifications 736,960 and 760,003, [both in Group IV (b)], are referred to.
PURPOSE:The titled dried material obtained by evaporating an aqueous solution containing a proteinic physiologically active substance and a polysaccharide having maltotriose residues as main repeating units to dryness. CONSTITUTION:A water-soluble dried material obtained by evaporating an aqueous solution containing a proteinic physiologically active substance, e.g. lymphokine or proteinic hormone, and a polysaccharide having maltotriose residues as main repeating units, e.g. pullulan or ercinan, at &lt;=30 deg.C under reduced pressure, preferably freeze-drying treatment, etc. to dryness, and containing the proteinic physiologically active substance. The resultant material is capable of retaining the activity of the physiologically active substance very stably, readily soluble in water, and effectively utilizable as a test reagent, injection, external drug, and internal medicine, etc. containing the above-mentioned physiologically active substance for prevention, treatment, etc. of human diseases.
An entry system includes a plurality of first user devices, such as key fobs, ID cards and the like. A plurality of second user devices are maintained by users, and may include mobile phones, smart watches and tablets. A main entry system controls a barrier to allow entry to approved individuals. An authorization system is configured to validate the first and second user devices, and to send an electronic questionnaire to the second user device. The user must complete the questionnaire and transmit it to the main entry system. The second user device, the main entry system, and the authorization system communicate with each other over a computer network. If the user successfully completes the questionnaire and the user&#39;s identity is authenticated, the main entry system allows the barrier to be opened so that the user may enter the facility.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an edible film for preventing sleepiness, while simply preventing the sleepiness and also having sustainability.  &lt;P&gt;SOLUTION: This edible film for preventing sleepiness is obtained by blending an edible film-constituting component, a sleepiness-preventing component and a cyclodextrin. The edible film for preventing sleepiness can prevent the sleepiness by the stimulation of the sleepiness-preventing component on putting it in a mouth in order to prevent the sleepiness generated during driving, working or studying at night/all night. For this purpose, it is possible to simply prevent the sleepiness by only putting the edible film for preventing the sleepiness into the mouth. Also, in the edible film for preventing the sleepiness, since the stimulation of the sleepiness-preventing component lasts, it is possible to prevent the sleepiness for a long period. Further, by the edible film for preventing the sleepiness, it is possible to prevent the adhesion of each of the edible films for preventing the sleepiness with each other even on preserving the edible films for preventing the sleepiness as a piled state.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
The invention discloses a traditional Chinese medicine for invigorating spleen and increasing appetite for animals. The traditional Chinese medicine is prepared from the following medicinal raw materials, by weight, 50-70 parts of haw, 30-40 parts of dried orange peel, 50-60 parts of malt, 20-40 parts of betel nut, 30-50 parts of Poria cocos, 10-30 parts of white peony root, 10-30 parts of licorice, 40-60 parts of Radix Astragali, 20-35 parts of wheat bran, 40-50 parts of apricot kernel, 15-30 parts of magnolia cortex, 40-60 parts of sophora flavescens and 30-50 parts of radish seed. In comparison with the prior art, haw, dried orange peel and malt are used as monarch drugs, betel nut, Poria cocos, white peony root and licorice are used as ministerial drugs, Radix Astragali, wheat bran and apricot kernel are used as adjuvant drugs, and magnolia cortex, sophora flavescens and radish seed are used as conductant drugs in the invention. The invention provides a traditional Chinese medicine for invigorating spleen and increasing appetite for animals. The traditional Chinese medicine has characteristics of promoting digestion, relieving stasis, replenishing qi to invigorate the spleen, regulating qi-flowing and stimulating one&#39;s appetite, and has no toxic or side effect. Meanwhile, production cost is low, and the processing technology is simple. By the use of the traditional Chinese medicine, immunity of livestock and poultry can be effectively raised, and yield of livestock and poultry can be increased.
The present invention relates to &#39;Buxueyimu Particles&#39; which are compound Chinese medicinal preparations for nourishing both qi and blood and removing blood stasis for promoting tissue regeneration. A making method of the present invention comprises the following steps: preparing Donkey-hide Gelatin powder, preparing a paste made from angelica and dried tangerine peel and preparing a paste made from milkvetch root and motherwort herb. After the two kinds of pastes are mixed to form the fine powder of the dry paste by spraydrying, the donkey-hide gelatin powder is mixed, and then the granulating step, the drying step, the checking step and the subpackaging step are carried out. The Buxueyimu Particles produced according to the present invention has refined recipe and outstanding curative effects and has the functions of vigorating qi, replenishing the blood and removing blood stasis for promoting tissue regeneration. The Buxueyimu Particles are new Chinese medicines for treating the deficiency of qi and the blood, blood stasis, etc. After operations and parturition, has low manufacturing cost and is worthy of being widely popularized and applied.
Medicinal tablets, intended to dissolve only on reaching a predetermined part of the digestive tract, are coated with a water-insoluble and indigestable base composition having incorporated therein an agent which, when acted upon by moisture, expands or is effervescent so as to disrupt the coating.  Bases specified are stearic acid, carnauba wax, petroleum jelly, mixtures of these three substances, hydrogenated vegetable oil, shellac, cellulose products such as nitro cellulose lacquer or a solution of celluloid in methyl acetone or solutions such as are used for preparing &#34;Cellophane&#34; (Registered Trade Mark), gum mastic, and gum benzoin.  Substances causing disintegration of the coating are agar, powdered elm, cinnamon bark, corn-meal, thyme, kaolin, and mixtures of tartaric acid with sodium bicarbonate. Choice of particular bases and of the added ingredients and the proportions in which they are mixed permit the period between ingestion and disruption of the coating to be varied.  According to one example, agar is mixed with a melted base consisting of carnauba wax, petroleum jelly and stearic acid.  The tablets may be coated by dipping, or the mixture may be allowed to set, pulverized and applied, in a rolling pan to tablets which have been coated with an adhesive such as shellac.  More than one such coating may be applied and the coated tablets may be used directly, or may be passed under a flame to seal them by fusing the surface of the coating.  In other methods, the tablets are coated with shellac and rolled in a pan with powdered agar, or are dipped in a solution of celluloid in methyl acetone to which tartaric acid and sodium bicarbonate have been added.  Reference has been directed by the Comptroller to Specification 427,106,
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a new medicine which inhibits protein kinase.  &lt;P&gt;SOLUTION: There is provided the compound of formula I or a pharmaceutically acceptable derivative thereof. These compounds are inhibitors of protein kinases, (particularly inhibitors of GSK3, Aurora2, and Syk mammalian protein kinases). There are also provided a pharmaceutically acceptable composition comprising the compound and methods of utilizing those compounds and compositions in the treatment of various protein kinase-mediated disorders. There is also provided a composition comprising the compound in an amount detectably inhibiting the GSK3, Aurora2, and Syk mammalian protein kinases activity, and a pharmaceutically acceptable carrier, adjuvant or vehicle.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PURPOSE:To obtain an antiviral polysaccharide substance useful as a drug, a food additive, a feed and a functional food, by refining the substance comprising as the component thereof polysaccharides including specific contents and having specific properties from an extract of Spirulina with boiling water. CONSTITUTION:An antiviral polysaccharide substance refined from an extract of Spirulina with boiling water (1) is polysaccharides contg. rhamnose, glucose, fructose, ribose, galactose, xylose, mannose, glucuronic acid, and galacturonic acid; (2) shows an absorption at 480nm in a phenol-sulfuric acid reaction; and (3) has a mol.wt. of 250,000 to 300,000 as measured by a gel filtration method. The word &#39;Spirulina&#39; means algae which belong to the genus of Spirulina, among which all species contg. an antiviral substance soluble in boiling water can be used. Use of algae which belong to Spirulina platensis, which have heretofore been used in many foods, is pref. in the above-mentioned polysaccharide substance as well.
The present invention relates to functional food with the action of blood sugar reduction and a preparation method of the functional food. The functional food with the action of blood sugar reduction The present invention relates to a functional food with the function of reducing blood sugar and its preparation method. Said preparation method includes the following steps: (1), pulverizing 2-4 portcan be prepared by the following method: 1) 2 to 4 portions of dry humifuse euphorbia herbs are taken and pulverized, water whose volume is 2 to 5 times of the volume of the dry humifuse euphorbia herions of dried humifuse euphorbia, adding water, boiling for 20-40 min, stirring and filtering, remaining filtrate, continuously boiling residue and repeating the above-mentioned steps, combining filtrb is added, and after the dry humifuse euphorbia herbs are boiled, boiling is kept for 20 to 40 minutes; a mixture of the dry humifuse euphorbia herb and the water is stirred continuously and filteredates; (2), extruding and dewatering ang-kak distillers&#39; grains, mixing 1-1.5 portions of ang-kak distillers&#39; grains with the above-mentioned humifuse euphorbia extract uniformly; and (3), vacuum-dryin, filter liquid is reserved, water of 1 to 3 times continues to be added in residue, and the residue is decocted; the steps are repeated, and finally, the filter liquid is merged; 2) 1 to 1.5 portionsg the above-mentioned mixture at 80 deg.C, pulverizing to obtain fine powder with 120 meshes so as to obtain the invented product.                                                                       of red infested rice grain stillage in which liquid is removed by extrusion is taken and is evenly mixed with humifuse euphorbia herb extraction liquid obtained in step 1), 3) a mixture of the red infested rice grain stillage and the humifuse euphorbia herb extraction liquid is dried in vacuum at the temperature of 80DEGC and is pulverized to fine powder of 120 meshes. The functional food with the action of blood sugar reduction can be capsules or tablets. The preparation method of the functional food with the action of blood sugar reduction is described. The present invention has the advantages of development of the blood sugar reduction function of the red infested rice grain stillage, changing of waste into valuable things, development of the humifuse euphorbia herb into the ingredient of health food for blood sugar reduction, simple formulation, cheap raw materials and simple manufacturing process; the humifuse euphorbia herbs can benefit to diabetic patients, and the compatibility of the humifuse euphorbia herbs and red infested rice grain stillage is proved to have good function of blood sugar reduction by experiments.
A user’s performance of an exercise, especially physiotherapeutic exercise, is directed and monitored. Body movements of a user (e.g. skeletal joint angles) are measured using a portable console having a range imaging sensor. The sensor measures the user during performance of the exercise and outputs resultant three-dimensional image data. The data is processed involving detecting the user in the image data and obtaining user biomechanical data representing skeletal movement. An on-screen user avatar is generated which moves in accordance with the measured data thus representing the user&#39;s exercise performance. Trainer biomechanical data representing body movement during proper performance of an exercise is stored, and used to generate an on-screen virtual trainer avatar. During performance of exercise by the user the virtual trainer avatar and the user avatar are displayed concurrently. Trainer and user movements may be compared to provide feedback to the user on their exercise performance. A peripheral device (e.g. handheld, attached to user or attached to an object) monitoring motion/orientation may also be provided.
A medicine containing Ampelopsis grossedentata(Hand.Mazz.)W.T.Wang[A.cantoniensis(Hook.etArn.)Planch.var.grossedentata Hand.Mazz.] and for prevention and treatment of hepatitis belongs to the technical field of Chinese herbal medicine processing. The medicine is prepared from Ampelopsis grossedentata(Hand.Mazz.)W.T.Wang[A.cantoniensis(Hook.etArn.)Planch.var.grossedentata Hand.Mazz.], scandent hop, radix angelicae, polygonum cuspidatum, pig&#39;s bile, Artemis sphaerocephala Krasch and EM original liquid, etc. By compatibility of the above medicines, the definitely effective medicine for treating hepatitis with syndrome of dampness-heat exuberance and jaundice is prepared. The medicine can be used for oral administration and external use, is more beneficial to rehabilitation of diseases, has excellent prevention and treatment effects, has high quality with reasonable price, and is very popular with people. Raw materials of the medicine are easily available. scandent hop has effects of clearing away heat and toxic materials and inducing diuresis for treating strangurtia, mainly treating dampness-heat obstruction syndrome, removing blood stasis and smoothing tri-jiao and benefiting the five internal organs. Ampelopsis grossedentata(Hand.Mazz.)W.T.Wang[A.cantoniensis(Hook.etArn.)Planch.var.grossedentata Hand.Mazz.] has effects of inducing diuresis and reducing edema, diminishing inflammation, easing pain and protecting liver. radix angelicae has effects of dispelling wind and eliminating dampness, opening orifice and relieving pain, and is good for eliminating liver diseases.
To provide a design and a synthesis of a novel positively-charged prodrug of a retinoid of a general formula (31)&#39; structure 31&#39; or a retinoid-like compound.SOLUTION: Positively charged amino groups of these prodrugs not only remarkably increase solubility of a drug in water but also couple with negative charge in a phosphate head part group of a film. The coupling disturbs slightly the film and can generate a space for a lipophilic part of the prodrug. When the film molecule moves, a little &#34;crack&#34; is generated in the film for coupling of the prodrug. Thereby, the prodrug is inserted into the film. The prodrug may be medically used to remedy a state remedial with the retinoid or retinoid-like compound in human beings or animals. The prodrug may be percutaneously administered to all kinds of medical remedies and can avoid almost all side-effects of the retinoids or retinoid-like compounds.SELECTED DRAWING: Figure 2
Systems and methods are provided for assessing competency of a health-care professional using a linear-narrative progression. The system includes a virtual console and an assessment tool. The virtual console is configured to present a clinical vignette to the health-care professional and display a series of digital images and questions to the health-care professional based on the clinical vignette. The virtual console is further configured to receive a response to each of the questions. The virtual console is also configured to display corrective instructions to the health-care professional after receiving a response to critical questions, wherein subsequent digital images and questions are based on the corrective instructions. The assessment tool is configured to assess the health-care professional&#39;s interpretation of each of the plurality of digital images.
PROBLEM TO BE SOLVED: To obtain a UV absorber having ability to absorb UV of both long and short wavelengths and giving no whitish appearance by forming a multiple metal oxide having a spinel or inverse-spinel structure. SOLUTION: The multiple metal oxide has a spinel or inverse-spinel structure represented by the formula AB2 O4 such as MgFe2 O4 and contains &lt;=0.5 mol one or more metals, based on 1 mol A, selected from among alkali metals, alkaline earth metals, transition metals, Al group metals and rare earth metals besides A and B. An aq. soln. of a water-soluble salt of A such as chloride, an aq. soln. of a water-soluble salt of B such as chloride, an aq. soln. of water- soluble salts of the selected metals such as chlorides and an aq. soln. of alkali ions or an acid are mixed in an autoclave, brought into reaction by heating, aged and optionally fired at &gt;=300 deg.C to obtain the multiple metal oxide. In the formula, A and B are selected from among Mg, Mn, Fe, Co, Cu, Zn, Al, Cr and Ti.