anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
Hair is treated with a composition comprising a mercaptan, a compound selected from the sulphites, bisulphites or metabisulphites of the alkali metals (sodium is mentioned) or ammonium, and a compound selected from formamide, thiourea or a compound derived from formamide by simple substitution of the carbon hydrogen atom, e.g. urea, acetamide or ethanol formamide. The hair may be &#34;cold-waved&#34; or, after application of the composition and winding the hair on curlers, the hair may be enclosed in a &#34;plastic&#34; cap and heated to 40 DEG  to 60 DEG  C., after which the hair is rinsed and may be exposed to facilitate aerial oxidation or may be treated with sodium perborate or hydrogen peroxide.  The composition may be in aqueous or aqueous-alcoholic solution and may also contain a vegetable or mineral oil, lauryldimethyl benzyl ammonium chloride, colouring matter or a perfume, and may be adjusted to a pH of above 7, e.g. from 9 to 10, with ammonia or sodium hydroxide.  The mercaptan may be thioglycollic acid or beta-mercapto-ethane sulphonic acid or their ammonium, amine, alkali metal or alkaline earth metal salts or glyceryl monomercaptan.  The composition may also be used in the straightening of curly hair.
NEW MATERIAL:The alcohol of formulaI(R is 1-3C alkyl) having a substituted norbornyl group. EXAMPLE:3-Methyl-4(tricyclo[5,2,1,0&lt;2&gt;,&lt;6&gt;]deca-8 and 9-yl)-butan-2-ol. USE:Useful as a perfumery component. It has mild woody perfume, e.g. similar to sandal-wood having green note, etc. It is colorless or pale yellow liquid having strong retainability and high compatibility with other perfumes, and is viscous oily material at room temperature. It improves the note of various perfumes when compounded therewith. PROCESS:The compound of formulaIcan be prepared by condensing the aldehyde of formula II with an ethyl alkyl ketone of formula III, followed by dehydration  and reduction.
An improved method and products for the hormonal treatment of breast cancer by breast implants of anti-estrogens and steroid hormones in formulations as fused with a lipoid carrier or encapsulated in microcapsules or in Silastic capsules is provided. Such breast implants renders a constant slow-release of their contents to the breast tissue for extended periods by biodegradation and diffusion. It facilitates higher breast tissue concentrations of anti-estrogen and hormonal compositions. Because of their high concentration in the breast and lower systemic distribution, tumor control is much improved and the their systemic toxicity is minimized. An added beneficial effect of these breast implants on breast cancer is mediated by the inhibition of hypothalamic-pituitary LHRH, FSH and LH secretion by these composition&#39;s systemic contents. It is also an effective prophylaxis against breast cancer. Furthermore, it reduces the cost of hormonal treatment of breast cancer. Anti-estrogen hormonal implants to the breast as concomitant hormonal treatment with conventional radiation therapy also facilitates improved tumor control and cure rates of breast cancer.
The invention provides a method for developing a new type of interactive information, diagnostic and rehabilitation services for people suffering from noise in the ear (tinnitus) and excessive sensitivity to sound (hyperacusis). The new type of service uses the possibilities offered by state-of-the-art computer technology and telecommunications. In particular, a multimedia computer software using the concept covered by the invention, installed locally or on a network computer, makes screening tests of ear noise possible. It uses an electronic questionnaire and presents examples of sounds that resemble ear noise to the subject. Thanks to its unique method of fitting masking sounds to the patient&#39;s needs, tinnitus patients can be rehabilitated using the masking or habituation method. The sounds selected to combat the patient&#39;s ear noise can be played back according to a shedule set up by the computer programme or downloaded into a miniaturised sound file player with earphones, worn by the patient. Alternatively, the sounds can be in the form of the high frequency dither noise generated in an external ultrasound generator and transmitted to the patient&#39;s ear using a miniature vibrational ultrasound probe.
Vaccines of the invention include at least four influenza virus strains. In some embodiments, the vaccines are produced in cell culture rather than in eggs. In some embodiments, the vaccines include an adjuvant. In some embodiments, the vaccines are not split or whole virion vaccines, but are live or purified glycoprotein vaccines. In some embodiments, the vaccines contain substantially the same mass of hemagglutinin (HA) for each of the influenza virus strains. In some embodiments, the four strains will include two influenza A virus strains and two influenza B virus strains (&#39;A-A-B-B&#39;). In other embodiments, the four strains will include three influenza A virus strains and one influenza B virus strain (`A-A-A-B&#39;).
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a carotinoid-containing emulsion composition being reduced in a smell such as oxidation smell and smell of fish, and also having excellent preservation stability; to provide a method for producing the composition, constituted of simple processes; to provide a food and an external preparation containing the composition; and to provide methods for producing them.  &lt;P&gt;SOLUTION: The carotinoid-containing emulsion composition contains at least the carotenoid, a deoxidized water and a metal-chelating agent. The method for producing the carotenoid-containing emulsion composition includes at least a step for preparing the emulsion by mixing the carotenoid with the deoxidized water and the metal-chelating agent. The food and the external preparation contains the carotenoid-containing emulsion composition. The methods for producing them are also provided.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
A method includes receiving (1704) characteristics of a patient to be administered a sedative for a medical procedure. The method also includes selecting (1706) one of multiple models (1514) based on at least one of the characteristics and a sedation technique to be used. The method further includes calculating (1708) an index to the selected model using one or more of the characteristics. In addition, the method includes identifying (1710) a specified dosage of the sedative using the selected model and calculated index. The characteristics of the patient could include a height, weight, age, and race of the patient. Selecting one of the models could include selecting one of the models based on the patient&#39;s race and the sedation technique. The models could include different models associated with different sedation techniques. Calculating the index could include multiplying the patient&#39;s height by the patient&#39;s weight and dividing a resulting product by the patient&#39;s age.
PROBLEM TO BE SOLVED: To produce a new compound, having strong hypoglycemic actions and useful as a therapeutic agent for diabetes and complications thereof. SOLUTION: This compound is represented by formula I (R&lt;1&gt; is a substituted phenyl, naphthalene which can be substituted with a lower alkyl or a substitutable 5- or 6-heterocyclic ring; R&lt;2&gt; and R&lt;3&gt; are each H or a lower alkyl; A is a lower alkoxy or =O; B is H, a lower alkyl, a lower alkoxy, etc.; either one of dotted line parts is a single bond and the other is a double bond), e.g. 5-[(1,3-benzodioxol-5-yl)methyl]-2-methylthio-6-trifluoromethyl-4(3H)- pyrimidinone. The compound represented by formula I is produced by reacting a β-keto ester derivative represented by formula II (R&lt;4&gt; is a lower alkyl) with a compound or a thiourea represented by formula III (R&lt;5&gt; is H, a lower alkylthio or a lower alkyl) in a solvent (e.g. methanol) at ambient temperature to the refluxing temperature of the solvent.
The invention provides a medical operation auxiliary system and method based on VR, algorithm and 5G technology, aiming at improving the immersion degree of VR. Through arranging the aerial view lens in the operating room, the panoramic video of the whole operating room can be collected, so that a user at the far end can feel the condition of the whole operating room in real time through VR glasses. In addition, the head of each doctor is respectively worn with a close-range lens, and when a user needs to observe the operation process at a close distance from the visual angle of a certain doctor, the user can click the target close-range lens worn by the head of the doctor in the panoramic video by utilizing the VR handle. The control module controls the target close-range lens to start to shoot the panoramic video of the operation at a close range, and the close-range panoramic video is sent to the VR glasses at the far end through the 5G communication module. As such, the user&#39;s perspective switches from the operating room global perspective to the surgical close-up perspective. The invention improves the immersion degree of VR by providing a flexible visual angle switching function.
PURPOSE:To provide the filter for capturing white blood cells which stably, efficiently and safely capture white blood cells irrelevant of a preservation temp. and number of days from blood and can be sterilized with high-temp. steam and the process for producing this filter. CONSTITUTION:The raw material compsn. consisting of at least one kind of polymer materials and the good solvent thereof and a pore forming material is formed and fixed on the surface of a porous base material selected from a group consisting of a woven fabric, non-woven fabric and knitted fabric consisting of fibers which have &lt;=10mum average diameter and do not denature the blood. This base material is immersed into a bath contg. the good solvent of the above-mentioned polymer material and a nonsolvent and is solidified; thereafter, the pore forming material is eluted away into this good solvent. The three-dimensional network-like open cellular porous body having 1 to 60mum pore size, 0.5 to 10m&lt;2&gt;/g specific surface area, 30 to 95% porosity, 0.08 to 0.30kg/cm&lt;2&gt; bubble point, 0.1 to 9.0mm thickness, and 6 to 90% surface opening rate is formed in this way.
1,243,321. 4 - Aminomethylbicycloheptane carboxylic acid derivatives. MERCK &amp; CO. Inc. 1 Jan., 1970 [13 June, 1969], No. 89/70. Addition to 1,209,799. Heading C2C. Novel compounds of Formula I and alkanoylamino esters and salts thereof wherein X is H 2  or 0 are prepared by reduction of a compound of Formula II  wherein Y is H 2  or -O-CH 2 -CH 2 -O followed if necessary by hydrolysis of the ketal groups to give the ketone and optionally followed by alkanoylation or ester or salt formation. Pharmaceutical compositions having antifibrinolytic activity being in conventional forms for oral and parenteral administration comprise an above novel compound or derivative and a carrier therefor.
The invention discloses a pill for cold blood disease. The pill is prepared by pure traditional Chinese medicines and is used for curing male and female sterility caused by &#39;cold blood&#39;. The &#39;cold blood&#39; is a main reason for male and female sterility in clinical summary. The cold blood is caused by three reasons. Firstly, the cold blood is inherited due to breast milk; secondly, a human is invaded by six climate exopathogens due to low physical quality when living at cold-dampness living and working environments; and thirdly, a woman likes cold drink, the representation is dysmenorrheal, the woman is afraid of cold extremely, the woman feels cold when others do not feel cold, and the woman is afraid of cold but does not have a sweat sense. The pulses of a human are low, unsmooth and slow. Medicines of the pill comprise 50 grams of rhizoma gastrodiae, 50 grams of Sichuan lovage rhizomes, 50 grams of cortex moutan, 50 grams of peach blossom petals, 50 grams of catkins, 50 grams of dried rehmannia roots, 50 grams of prepared radix rehmanniae, 50 grams of shizandra berries (denucleation ), 50 grams of white poria, 100 peach kernel grains, 500 grams of raspberries and 500 grams of dodders. Diseases of such type are increased gradually. The pill can cure diseases of both females and males.
PROBLEM TO BE SOLVED: To obtain a solid teprenone agent stably preservable over a long period. SOLUTION: Teprenone is used singly or in combination with &gt;=1.0wt.% of L-ascorbic acid or erythorbic acid or their salt, supported on a powdery carrier (e.g. light silica) and prepared in the form of a drug. The amount of teprenone to be supported on the powdery carrier is about 0.05-2 pts.wt. based on 1 pt.wt. of the carrier. The product is optionally compounded with arbitrary other components and prepared in the form of powder, fine particle, granule, etc. The decomposition of teprenone can be prevented and a stable solid agent can be prepared even by using water-soluble L-ascorbic acid, erythorbic acid, etc., as an antioxidant by supporting the acid on a powdery carrier at the aforementioned ratio.
PROBLEM TO BE SOLVED: To enable a user of a remote place to get access to information by incorporating a browser into an ultrasonic device. SOLUTION: A browser 100 by which a user of an ultrasonic device 10 can communicate with the other site through a hypertext link, is incorporated into the ultrasonic wave 10. The browser 100 contains software to enable an operator look at a hypertext document which exists in a remote place from the ultrasonic device 10 or is preserved in a server 30 on the ultrasonic device 10 itself. This browser 100 is connected to an ultrasonic device controller 18, and is made to perform mutual work with an ultrasonic device storage medium 24 and a display device. It is made operable by a user interface of the ultrasonic device 10. A hypertext link of a displayed HTML page is &#39;clicked&#39;, and a browser display is operated by a keyboard 22 or a track board 26, and desired information is selected by a selecting key 27. In this way, the information can be obtained in a remote place.
A method for grafting a cell in the brain of a mammalian subject is accomplished by attaching the cell to a support matrix so that the cell attaches to the matrix surface, and implanting the support matrix with the attached cell into the brain. Preferred support matrices are glass or plastic microbeads, either solid or porous, having a diameter from about 90 to about 125 μm. The method employs cells of different types, preferably cells of neural or paraneural origin, such as adrenal chromaffin cells. Also useful are cell lines grown in vitro. Cells not of neural or paraneural origin, such as fibroblasts, may also be used following genetic alteration to express a desired neural product such as a neurotransmitter or a neuronal growth factor. The method is used to treat neurological diseases such as Parkinson&#39;s disease, Alzheimer&#39;s disease, Huntington&#39;s disease, epilepsy, and traumatic brain injury.
PURPOSE: To obtain a skin temperature-increasing agent giving a warm feeling to skin by increasing skin temperature, preventing or moderating the oversensitivity to cold and cold feeling, and further activating the metabolism of skin by including a specific phthalide derivative or its salt as an active component. CONSTITUTION: This skin temperature-increasing agent contains a phthalide derivative or a salt thereof expressed by the formula (R&lt;1&gt; is H, OH, methoxy, amino or dimethylamino; R&lt;2&gt; and R&lt;3&gt; are each H or methoxy; R&lt;4&gt; is H, amino or dimethylamino; R&lt;5&gt; is H, an alkyl or an alkoxy; R&lt;6&gt; is H or an alkyl) (e.g. 3-octylphthalide) as an active component. The phthalide derivative or the salt thereof expressed by the formula may also be, e.g. an organic solvent extract with ethanol or hot water, etc., from a plant of family Apiaceae. Otherwise, it may also be synthesized by obtaining an alkylidene phthalide derivative, by a heating reaction of a phthalic acid anhydride derivative with an acid anhydride, followed by hydrogenation.  The skin temperature-increasing agent induces effects such as recovery from fatigue, improvement of beautifulness, prevention of aging and increasing of drug penetration into the skin.
PROBLEM TO BE SOLVED: To provide a terminal which can more efficiently input the physical situation of a patient and which can easily grasp a part where the physical situation is generated. SOLUTION: In the portable terminal, an operator indicates the part to which the physical situation is inputted on a human body diagram by tapping it with a pen. Then, the list of the physical situations which probably occur in the part is displayed in a pop up list. When the physical situation to be inputted is selected, the pop up list of the value of the physical situation is displayed. The value becomes a value showing the degree of &#39;heavy&#39; and &#39;light&#39;. When the operator selects the degree from the pop up list, the value is inputted as the physical situation. Thus, the operator can easily input the physical situation only by tapping with the pen and the like.
PURPOSE:To selectively remove the low-sp.gr. lipoprotein in the body fluid by forming the title adsorbent having a synthetic chain polymer having a carboxyl group and a sulfate or sulfonate group and having a specified range of mol.wt. on the surface of adsorbent, and using the adsorbent. CONSTITUTION:A carrier is activated, and covalent-bonded with the synthetic chain polymer having 5X10&lt;3&gt;-5X10&lt;6&gt;mol.wt. and having a carboxyl group and a sulfate or sulfonate group to form the low-sp.gr. lipoprotein adsorbent. The adsorbent has the synthetic chain polymer part having 5X10&lt;3&gt;-5X10&lt;6&gt;mol.wt. and having a carboxyl group and a sulfate or sulfonate group on the surface, and the ion exchange capacity is 1-300mueq/ml (wetting capacity). A cellulose- based gel, a dextran-based gel, etc., can be used as the carrier. Besides, the carrier is activated by a cyanogen halide method, an epichlorohydrine method, etc.
A new method of designing and generating compounds having an increased probability of being drugs, drug candidates, or biologically active compounds, in particular having a therapeutic utility, is disclosed. The method consists of identifying a group of bioactive compounds, preferably of diverse therapeutic uses or biological activities and built on a common building block. In this group of compounds, side chains modifying the building block are identified and used to generate a second set of compounds according to the proposed methods of &#34;hybridization&#34;, &#34;single substitution&#34; or &#34;incorporation of frequently used side chains&#34;. If the compounds in the second set built on the same building block contain an unusually large number of drugs, preferably with diverse therapeutic uses or biological activities, they constitute a &#34;hot spot&#34;. A focused combinatorial library of the &#34;hot spot&#34; is then generated, preferably by methods of combinatorial chemistry, and compounds of this library are screened for a variety of therapeutic uses or biological activities. The method generates drugs, drug candidates, or biologically active compounds with a high probability, without requiring any prior knowledge of biological targets.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a hair grower having greater hair growing effects than those of a hair grower using purified proanthocyanidin and having sufficient hair growing effects.  &lt;P&gt;SOLUTION: The hair grower comprises a plant body extract extracted from the plant body as an active ingredient. The hair grower comprises the proanthocyanidin and an ingredient other than the proanthocyanidin as the active ingredient. The ingredient other than the proanthocyanidin in an amount of ≥10 mass% is contained in the solid components. The hair grower having high effect is obtained by preferably using pine tree bark as the plant body.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
A device for controlled sequential delivery of a plurality of different medicaments in a predetermined sequence to humans or animals. A device for delivering one or more medicaments to a living body, the device comprising: a first layer 2 comprising graphene and a metal composite; a second layer 10 comprising graphene and/or a graphene composite; a third layer 8 comprising a medical dressing thats located between first and second layers 2&amp;10. The one or more medicaments are releasably contained within second layer 10. The one or more medicaments may be released upon applying an electrical charge to first and/or second layers 2,10. Where there is more than one medicament, they may be released sequentially by applying electrical charges of increasing strength to first and/or second layers 2,10. Applying electric charge to first and/or second layers 2,10 may structurally modify the graphene so releasing medicament. The device may be wrapped around a body part, possibly secured by a zip fastener 4, where the zip 4 may act as a power source for the device. An electric charge applied to first and/or second layers 2,10 may cause the device to increase pressure on a body part to which the device is applied. The metal composite may comprise one or more metals selected from copper, zinc, platinum, silver, gold, nickel, gallium, or cobalt.
The invention includes a wireless multifunction veterinary thermometer device that communicates with a mobile communication device running an app for recording animal temperature data and to display animal treatment options considering the recorded data and ambient weather conditions. Treatment options may be determined by logic programmed within the app or by another computer program associated with a remote server and database. Data transfer takes place between the mobile device and the remote server/database. A heat stress indicator is displayed for the user. If the indicator represents a high heat stress level, the app logic or remote computer program may automatically generate a recommended treatment option, or the user may determine an appropriate treatment.The invention includes a wireless multifunction veterinary thermometer device that communicates with a mobile communication device running an app for recording animal temperature data and to display animal treatment options considering the recorded data and ambient weather conditions. Treatment options may be determined by logic programmed within the app or by another computer program associated with a remote server and database. Data transfer takes place between the mobile device and the remote server/database. A heat stress indicator is displayed for the user. If the indicator represents a high heat stress level, the app logic or remote computer program may automatically generate a recommended treatment option, or the user may determine an appropriate treatment. The present disclosure is directed to apparatus, systems, and methods to allow a user to create virtual and real-world game content to provide players with physically engaging virtual content that is anchored to real-world locations. A content creator is provided a set of &#34;drag-n-drop&#34; modular assets (e.g., encounter tiles, content tiles, creatures, chests, rooms, vehicles, etc.) that can be aggregated together to form a complete content set (e.g., a dungeon, level, puzzle, etc.) through which a player is able to engage the game via the real-world. Each individual modular asset may include a set of in-game challenge criteria that must be satisfied to complete an in-game challenge associated with the asset.