anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a product which avoids problematic points of products and methods known beforehand and which is efficient and effective for delivering nicotine to the lungs, being an object in principle; and a method and apparatus, both for producing the product.  &lt;P&gt;SOLUTION: A buffered liquid nicotine composition is provided, which consists of a 7 liquids medicinal preparation including nicotine in anyone shape for administration into lung in principle. The medicinal preparation is acidified and/or alkalized by buffering and/or pH adjustment and brings about t&lt;SB&gt;max&lt;/SB&gt;of nicotine in arterial blood of an objective instantly after administration. Preferably, the administration includes spraying an aerosol agent into oral cavity in principle for further delivery into lungs. Similarly, a method for producing the medicinal preparation and the use of the medicinal preparation in a treatment method, for example, for treating tobacco dependence, are included.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
A method of treating avascular necrosis (&#39;AVN&#39;) comprising administering one or more osteoinductive formulations to the site of AVN disease progression. The method involves the combination of a core decompression technique, followed by the introduction of one or more osteoinductive formulations into the decompression core, and concluding with capping of the ateral aspect of the decompression core with a femoral core cap. The osteoinductive formulations of the invention comprise one or more osteoinductive agents and suitable carrier molecules. The femoral core cap retains the osteoinductive formulation within the decompression core, thereby preventing leakage of the osteoinductive formulation from the decompression core. The method of the invention optionally comprises introduction of autograft or allograft with the osteoinductive formulations of the invention. The method of the invention further optionally comprises incorporation of sustained release compositions to provide extended periods of osteogenesis.
The novel positively charged prodrugs of acetylsalicylic acid and its analogues in the general formula(1) &#39;Structure 1&#39; were designed and synthesized. The compounds of the general formula(1) &#39;Structure 1&#39; indicated above can be prepared from functional derivatives of ASA or its analogues,(for example acid halides or mixed anhydrides), by reaction with suitable alcohols, thiols, or amines. The positively charged amino groups of these pro-drugs not only largely increases the solubility of the drugs, but also bonds to the negative charge on the phosphate head group of membranes and push the pro-drug into the cytosol. The experiment results suggest that the pro-drug, diethylaminoethyl acetylsalicylate.AcOH, diffuses through human skin ~400 times faster than acetylsalicylic acid itself and ~100 times faster than ethyl acetylsalicylate. In plasma, 80% of these pro-drugs can change back to the drug in a few minutes. The pro-drugs can be used medicinally in treating any aspirin-treatable conditions in humans or animals and be administered not only orally, but also transdermally for any kind of medical treatments and avoid most of the side effects of aspirin, most notably GI disturbances such as dyspepsia, gastroduodenal bleeding, gastric ulcerations, and gastritis. Controlled transdermal administration systems of the prodrug enables the aspirin to reach constantly optimal therapeutic blood levels to increase effectiveness and reduce the side effects of aspirin.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for producing a polyclonal antibody against specific antigen, etc.  &lt;P&gt;SOLUTION: A cDNA is prepared from multiple kinds of cells expressing an antibody. Multiple kinds of genes encoding an antibody against a specific antigen are separated from the cDNA to prepare a gene mixture composed of the genes. The gene mixture is brought into contact with a vector to prepare multiple kinds of recombinant vectors containing inserted genes encoding an antibody against a specific antigen and prepare a vector mixture composed of the recombinant vectors. The vector mixture is brought into contact with a host cell to prepare multiple kinds of recombinants containing the introduced recombinant vectors and prepare a recombinant mixture composed of the recombinants. The recombinant mixture is cultured by mix culture and a mixture of multiple kinds of antibodies against a specific antigen is collected from the cultured product.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a moisturizing plant extract with sustainable moisturizing effect for a long time, and to provide an external care preparation, a cosmetic, a bathing agent and a cleanser composition each containing the extract.  &lt;P&gt;SOLUTION: The moisturizing plant extract consists of an extract from a mixture of Zizyphus jujuba Miller var. inermis Rehder, Glycyrrhiza uralensis Fisher or Glycyrrhiza glabra Linne, Platycodon grandiflorum A. De Candolle and Zinziber officinale Roscoe. The external preparation, cosmetic, bathing agent and cleanser composition each containing the extract are also provided, respectively. A product made by decocting a prescribed ratio of the above-mentioned crude drugs is called Hainoutou in the traditional Chinese medical science, being identical to a composition with medicaments regarded as being used in the early stages of suppurative dermatoses by oral administration. The above extract contains moisturizing plant components with sustainable moisturizing effect for a long time, and exhibits effects, by external use, on preventing, mitigating or ameliorating dry skin, rough skin, chapped skin, itching and inflammatory diseases, and on the hair, in curing dryness, rough feeling, split hair and broken hair and imparting gloss, and the like.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
PURPOSE:To prepare the titled composition containing glycerol, D-sorbitol and xylitol as active components, and exhibiting sufficient effect at low dose. CONSTITUTION:The objective transparent liquid laxative composition having mitigated undesirable taste and smell and agreeable to take, is prepared by mixing glycerol, D-sorbitol and xylitol at weight ratios of (1-3):(1-3):(1-5). The effect of the above composition can be attained only by using two or three kinds of the above compounds in combination. When two of the above compounds are used in combination, the ratio of the compounds is same as defined above. The composition may be used as a solution by dissolving in a proper solvent (e.g. water, mixture of ethanol and water, etc.) at an active component concentration of 50-100% (excluding 100%). Dose: 0.1-0.5g of the active component per kg daily. The LD50 of the above composition is &gt;20g/kg, and the composition has high safety.
PROBLEM TO BE SOLVED: To obtain a skin beautifying promoter capable of raising water holding properties of the skin and affording the moist skin with a fine texture by oral ingestion. SOLUTION: This skin beautifying promoter is obtained by including an enzymic hydrolyzate of a swallow&#39;s nest as an active ingredient. The enzymic hydrolyzate is preferably a hydrolyzate with a protease. The molecular weight of the enzymic hydrolyzate is preferably 2,000-70,000. The skin beautifying promoter preferably contains collagen and/or its enzymic hydrolyzate and further preferably contains at least one kind selected from glucosamine, a nucleic acid, an SOD like substance, an SOD activity inducer and lactoferrin. Furthermore, at least one kind of a cultured product obtained by culturing lactic acid bacteria, enterococci, yeasts or fungi is preferably contained.
Methods and compositions are provided for inhibiting, preventing and treating amyloid depositions, e.g. in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. Accordingly, the compositions and method of the invention are useful for inhibiting diabetes. The invention also provides a process for the preparation of cells suitable for transplantation into a mammal, which cells are capable of forming fibrils, said process comprising contacting the cells with an inhibitor of fibril formation. In particular the process prepares cells for use in a method of treating diabetes. Also provided are a culture medium comprising the inhibitor more particularly selected from the group consisting of 3-(3-hydroxy-1-propy)amino-1-propanesulfonic acid; DL-2-amino-5-phosphovaleric acid; 4-Phenyl-1-(3&#39;-sulfopropyl)-1,2,3,6-tetrahydropyridine, cyclohexylsulfamic acid, O-phospho-L-serine, hexafluoroglutaric acid, 8-methoxyquinoline-5-sulfonic acid, 3-amino-2hydroxy-1-propanesulfonic acid, and 3-dimethylamino-1-propanesulfonic acid and 1,2,3,4-tetrahydroisoquinoleine.
NEW MATERIAL:A compound of formula I [X is -O-mycinose or di(lower alkyl) amino; R&lt;1&gt; is H or lower alkanoyl; R&lt;2&gt; is lower alkyl, cycloalkyl-lower alkyl, etc.; R&lt;3&gt; is H or OH] or a salt thereof. EXAMPLE:9-Dihydro-9-O-methyldesmycosin. USE:An infectious disease remedy. The compound exhibits an excellent infectious disease-treating effect when orally administered. PREPARATION:The aldehyde group of a desmycosin derivative of formula II is first protected and the protected product is reduced with an alkali borohydride such as sodium borohydride in a solvent such as methanol. The prepared compound of formula III (R groups are lower alkyl, respectively, or two of the R groups form a lower alkylene) is reacted with an alcohol of a formula: R&lt;2&gt;-OH in the presence of an acidic catalyst, followed by removing the aldehyde-protecting group of the reaction product.
The efficacy of plant and animal active substances, especially hormones, regulatory factors, transmitters, enzymes, and of vitamins and trace elements is improved by binding them to polypeptides, peptides and/or nucleotides as carriers and additives which are obtained from microbial, plant and/or animal macromolecules by chemical hydrolysis or enzymatic degradation. Alkalisation of the loaded carriers and additives, also using trace elements and possibly surface-active substances, counteracts the environmental damage of the flora. It is also possible to use energy-transferring systems. &#34;Tree death&#34; resulting from difficulty in adapting to environmental changes is a preferred area of use, but also likewise the improvement of the utilisation and efficiency of feedstuffs and resistance to infections and stress in the rearing of productive livestock and the prophylaxis and therapy of damage from ionising radiation and cytotoxic substances. The efficacy of drugs in human and veterinary medicine is improved and protracted. The products are added to the nutrient media in bacteriology to stimulate the growth of microorganisms, and in tissue culture to improve the growth of cell cultures and to retain the specificity and the cell-division capacity.
The invention relates to instruments for auscultation and can be used for real-time telemedicine consultations and telemedical monitoring. A digital stethoscope comprises a device for detecting analog acoustic signals from a patient, and a data processing system implemented via a safe encrypted web application on a portable computing device of the patient and/or the doctor with headphones connected. Software processing of data is carried out on the device of the doctor and/or the patient. Information about the patient is obtained and stored. Digital data is converted into an audio signal. The audio signal is displayed in the form of an audiogram in the window of the doctor&#39;s web browser. The audio signal is processed on the basis of user settings. The processed audio signal is output to the headphones. Data about the digital filters applied is stored. The result is in an increase in the quality and speed with which a signal is processed, while reducing energy consumption and allowing the safe auscultation of patients with highly infectious diseases such as, for example, COVID-19. The stethoscope can be used with several wireless headsets simultaneously on several user devices, taking into account the individual psychoacoustic profiles of the users and the different psychoacoustic perception of sounds by different specialists.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a lipid metabolism-improving composition having a high lipid metabolism improvement function using only a Vitaceae plant without adding an additive.  &lt;P&gt;SOLUTION: The lipid metabolism-improving composition is extracted using a Vitaceae plant as a raw material. The composition is extracted using a fruit of a wild vine and/or a squeezed residue of the fruit and dried to obtain a powder. The powder contains 5 wt.% or more of polyphenol as an active ingredient, wherein the weight ratio of coexisting carbohydrate to the polyphenol is 0.1-19. The polyphenol contains procyanidin in an amount of 40 wt.% or more. The average polymerization degree of the procyanidin is 6 or less.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
PURPOSE:To exactly measure the specific antibodies of various classes and to enhance the ease and rapidness of operations by previously removing immune globulins, exclusive of the class of the specific antibody to be measured. CONSTITUTION:The immune globulins exclusive of the specific class to be measured are previously removed from the body fluid specimen. The immune globulins to be removed are in principle IgG, IgA, IgM when the specific antibody to be measured is IgE, are IgG, IgA, IgE when the antibody to be measured is IgM, are IgG, IgM, IgE when the antibody to be measured is IgA, and are IgA, IgM, IgE when the antibody to be measured is IgG. The serum concns. of these immune globulins are IgG&gt;&gt;IgA&gt;IgM&gt;&gt;IgE. Only the immune globulins of the other classes having the large probability to affect the measured value of the antibody to be measured are, therefore removed.
No intervention will be made to individuals participating in this group. The VAS form will be filled out at the 10th, 24th, 48th and 72nd postoperative hour. The patient\&#39;s total mobilization time and the number of breathing exercises will be recorded. The postpartum comfort scale will be filled in at the 10th and 72nd hours.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a technique for improving an elastic index as a visco-kinetic characteristic in a cosmetic such as massage cosmetic.  &lt;P&gt;SOLUTION: This cosmetic is an emulsifying composition containing 10-60 mass% oil and fat component having fluidity under conditions of 1 atmospheric pressure and 37°C. In the cosmetic, (1) 0.1-20 mass% of the oily component is an ester of a dimer acid and (2) 0.1-20 mass% of the oily component is one or more kinds of substances selected from a glycerol fatty acid adipic acid condensation product, a castor oil isostearate and a diester of 5,7,7-trimethyl-2-(1,3,3-trimethylbutyl)-octane-1-ol and a malic acid diester. The cosmetic is preferably an oil-in-water type emulsifying agent and the cosmetic is preferably a massaging agent. A dimer dilinolic acid dimer dilinoleyl is preferable as the dimer acid ester.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
PURPOSE: To obtain an antiviral agent having potent antiviral, action, thus effective for various viral diseases such as herpes virus infectious diseased and AIDS, containing, as active ingredient, a cyclobutane derivative having specific structure. CONSTITUTION: This antiviral agent contains as active ingredient a (1R,2R,3S) cyclobutane derivative of formula I (B is a purine base; R&lt;4&gt; is H or a protecting group) e.g. 9-[(1R,2R,3S)-2,3-bis(hydroxymethyl)cyclobutan-1-yll-adenine}. The compound of formula I is obtained, for example, by reaction between a compound of formula II (X is an eliminable group) and a purine base such as adenine, guanine or 2-aminopurine. It is preferable that the above reaction be carried out at room temperature to 170 deg.C in a solvent such as DMF using 1-5 equivalents of the purine base per equivalent of the compound of formula II. The compound of formula I can be orally, intravenously or percutaneously administered, its dose being normally 0.1-500mg/kg b.w. a day.
PURPOSE:To obtain the titled lens having an excellent thermal resistance by polymerizing a mixture of a styrene monomer and a radical polymerizable monomer having two or more than two ethylenic bonds in a specific ratio and casting it and by molding the obtd. cast plate having more than a prescribed values of a refractive index and total transmittance of light using a mold for the lens with heating under a pressure. CONSTITUTION:The polymer plate is prepared by polymerizing the mixture composed of &gt;=0.4 wt.% monomer shown by formula I wherein R and R&#39; are each H or CH3 group, R and R&#39; can not be both CH3 group, and 0.001-0.3 wt.% monomer having two or more than two ethylenic bonds in the molecule and optionally an another monomer such as methylmethacrylate, and casting it. The lens is prepared from the obtd. polymer plate using the mold having a fresnel lens surface 10 and a lenticular lens surface 11 by heating under the pressure. By treating the polymer plate as mentioned above, the lens having advantage capable of making a depth of a projection type television small, and having the high refractive index and the excellent chemical resistance, is obtd.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide coated spherical powder having high light-scattering effect, blurring wrinkle, liver spot, etc. and preventing powdery feeling, shininess, etc. and a cosmetic composition in which the powder is formulated.  &lt;P&gt;SOLUTION: The above problem is solved by using the coated spherical powder obtained by coating the surface of spherical resin powder with flaky titanium oxide. The cosmetic composition in which the powder is formulated is effective, because the composition has extremely high effects of blurring wrinkle and liver spot and preventing powdery feeling and shininess, etc.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
Substantially pure Vitamin B12 is separated from impure aqueous concentrates containing it together with undesired accompanying factors predominantly of an electroneutral character, by extraction from the concentrate with a mixture of a non-polar solvent and a solvent containing a phenolic hydroxyl group, adsorption from the solvent phase on to a microporous inorganic adsorbent and elution from the adsorbent with a polar solvent from which the Vitamin B12 is crystallized.  When using a mixture of phenol and chloroform in the initial extraction, the ratio of these components is preferably 1:6. Alternatively as phenolic solvent there may be used cresol or chlorophenol and as the non-polar solvent there may be used carbon tetrachloride, ethylene chloride and benzene.  As adsorbent, aluminium oxide, fuller&#39;s earth, diatomaceous earth and silica gel may be employed.  The aqueous polar solvent employed in the final elution may be acetone, ethanol or propanol.  Adsorption may be effected by adding the adsorbent directly to the solvent phase. The adsorbent is separated therefrom, e.g. by filtration.  An example describes the process in detail.  Specifications 675,247 and 677,487 are referred to.
A specially effective method for treating external wounds with stropanthus divericatus belongs to the technical field of disease treating with Chinese herbal medicines for external use. The specially effective method includes decocting stropanthus divericatus, elephant hide, common bletilla pseudobulb and small amount of L-Cystine to wash scald wounds, and grinding stropanthus divericatus seeds, cutch, dragon&#39;s blood, red halloysite and L-Cystine into fine powder to apply to wounds with infected ulcer. By the method, wounds heal fast, the effects of diminishing inflammation, preventing bacterial, dispelling pus and toxin, relieving swelling and pain, promoting tissue regeneration and healing are achieved, and no scars are remained. Most external wounds inflame with constant percolate or infected ulcer, is covered with impetigo, and aches a lot, which belongs to heat-toxin in traditional Chinese medicine. Stropanthus divericatus with relatively large toxicity is used as monarch drug for treating scalds and wound ulcer, toxin is used to combat toxin, and fine effect is achieved. Drugs having the effects of diminishing inflammation, preventing bacterial, relieving pain, relieving swelling, astringing, promoting tissue regeneration and healing, such as elephant hide, common bletilla pseudobulb, dragon&#39;s bone, red halloysite, L-Cystine, cutch and dragon&#39;s blood, are used as ministerial drugs.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a cosmetic that is used for a face pack in gel, has a layer of an exothermic composition, is heated to a temperature suitable for application to the skin in a short time by bringing the exothermic composition into contact with oxygen in air and by continuing the temperature suitable for application to the skin during a use time of the pack cosmetic.  &lt;P&gt;SOLUTION: The sheetlike pack cosmetic comprises a pouched part having an air-permeable side and an air-impermeable side, a substrate layer for gel formed on the external surface of the air-impermeable side and a gel layer formed on the substrate layer for gel. The exothermic composition is sealed in the pouched part. The air permeability of the air-permeable side is 300-2,300g/m&lt;SP&gt;2&lt;/SP&gt;×24 hours measured by a Lyssy method (40°C, 90%RH). The temperature of the gel layer reaches ≥38°C within 10 minutes and then the temperature of 38-45°C is kept for ≥20 minutes measured by a temperature measurement method on the basis of JIS S 4100.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a medical education network system that allows taking courses on medical techniques in the form of classes by utilizing the Internet and mobile terminals.  &lt;P&gt;SOLUTION: The medical education network system comprises training equipment having a training server, an image measuring and diagnostic device, a camera, a microphone and speakers, and installed in a training center; and mobile terminals connected to the training server via a communication means. The training server includes a communication interface connected to the communication means; a digital data input/output part; a course execution control means; a data management control means; and a data storage device. The data storage device has a medical image database, a camera image database, a diagnosis support information database, a patient information database, a question/right answer information database, and a teaching video database, all constructed therein. The course execution control means sends explanations or questions using medical images to the mobile terminals in accordance with the content of a predetermined course selected from the question/right answer information database.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT