anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
The present invention relates to &#34;structured synthetic antigen libraries&#34; (SSAL) composed of related peptides synthesized simultaneously in a single peptide synthesis. This &#34;stuctured&#34; library contrasts to those libraries previously described as &#34;random peptide libraries&#34; in that the order or structure within a synthetic antigen is provided by invariant amino acid residues that define the framework sequence of the synthetic antigen. The specific amino acids and their frequency of appearance at a variant locus within aligned peptide sequences is defined by the primary sequences of the several variants that make up the alignment used to construct the antigen peptide library. A method of constructing an open diagnostic, vaccine or therapeutic for a mutational infectious agent is also provided. The invention further provides the SSAL in diagnostic methods, kits vaccination methods, vaccine compositions and pharmaceutical compositions. The libraries are prepared from variable domains in proteins and provide improved vaccines, diagnostics and therapeutics for infectious agents, etc., from such proteins.
&lt;P&gt;PROBLEM TO BE SOLVED: To make active compounds that have a very-low bioavailability into more bioavailable form.  &lt;P&gt;SOLUTION: A pharmaceutical composition includes a molecular dispersion which comprises a tricyclic amide compound of formula I. The compound is molecularly dispersed in a polymer matrix. In one embodiment, the polymer matrix can contain a water-soluble polymer. Further in another embodiment, the polymer used for the polymeric matrix is selected from the group consisting of polyvinylpyrrolidone, hydroxypropylmethylcellulose, hydroxypropyl cellulose and polyethylene glycol.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
PURPOSE: A system for digital scale designed to output diet information transmitted through the internet is provided to display and print the diet information transmitted through the internet. CONSTITUTION: A user&#39;s weight is measured(S702) and the user inputs the user input information through a keyboard, which is installed on a digital scale(S704). A server computer&#39;s communication interface receives the user&#39;s weight and input information from the digital scale. The server computer&#39;s user identifier identifies the user by determining whether the user ID from the transmitted user information is identical to the stored user ID(S706). If the user ID is not identified by the user identifier, the digital scale user registers one&#39;s user ID in the server computer(S708). The server computer&#39;s weight difference calculator calculates the difference between the transmitted weight and the weight stored in a DB(S710). The weight difference calculator calculates the necessary daily calory amount based on the daily calory consumption amount and the body fat level that are stored in the DB(S712). The server computer&#39;s diet information generator responds to the necessary daily calory consumption level and transmits the diet information through the internet(S714). The received diet information is displayed on an LCD screen or printed by a printer(S716).
Automatic test tracking analysis and reporting are provided by an automated process and computer system, which can provide a global communications network, for the convenience of patients, health care providers and public health agencies to lower health care costs. Advantageously, the speedy accurate process and system can be used to detect many types of infectious diseases, chronic diseases, genetic diseases, nutritional deficiency, environmental and general health problems, fertility, mental disorders, drug abuse, allergies, etc., as well as to automatically administer non-invasive tests, such as vision tests, hearing tests, and cognitive function tests to monitor the progress of Alzheimer&#39;s disease. Samples to be tested can be conveniently collected by the patient or by others and placed in a test kit at the patient&#39;s home or other location remote from a medical facility. The sample can be tested in a laboratory or at the patient home or other remote site. The test results and patient profile medical history can be inputted into the system or network and compared with data bases of diseases, disorders, treatments, care plans, nutritional supplements, and medicine. The process and system can transmit an analysis and proposed treatment to the patient&#39;s physician or health care provider for approval or change before the test report and recommended medicine and treatment are sent to the patient. The process and system are also useful for automatic test tracking and reporting to public health organizations.
PROBLEM TO BE SOLVED: To obtain a polyvinyl alcohol hydrogel composition which has high mechanical strengths and an excellent cleaning force. SOLUTION: This polyvinyl alcohol hydrogel composition for oral cavities comprises the complex of polyvinyl alcohol with a compound containing at least two acid anhydride structures in the molecule. The polyvinyl alcohol (PVA) includes the conventional polyvinyl alcohol. The PVA has a number- average polymerization degree of preferably &gt;=500, more preferably &gt;=700. The upper limit of the number-average polymerization degree is preferably not limited, but is usually about 5, 000. The mol.wt. of the compound containing at least two acid anhydride structures in the molecule is especially not limited, but is preferably limited to a range exhibiting a solid state at the ordinary temperature.
The invention relates to an acidified albumin and a preparation method thereof, and an application of the acidified albumin in inhibiting beta-amyloid protein aggregation. According to the invention, diglycolic anhydride is modified on the amino group on the surface of serum albumin, such that a product with isoelectric point of 3.8-4.3 and with diglycolic anhydride average modification number between 3 and 14.5 is obtained. The product is the acidified albumin. Diglycolic anhydride powder is added into a solution of serum albumin dissolved in deionized water and with a concentration of 1-20mg/mL; a sodium hydroxide solution is dropped in at a same time, such that the pH value of the reaction liquid is stably maintained at 6.0-7.0; a stirring reaction is carried out for 0.5-5h under room temperature; and free diglycolic anhydride is removed, such that acidified serum albumin with a stable molecular structure is obtained. According to the acidified serum albumin provided by the invention, serum albumin surface negative charge amount is improved, such that the interaction of serum albumin and Abeta is promoted, and thus Abeta aggregation is inhibited, and beta-amyloid protein aggregate cytotoxicity is reduced. The acidified albumin is used in medicines used for treating Alzheimer&#39;s disease and beta-amyloid protein aggregation-related diseases.
FIELD: veterinary science, agriculture. SUBSTANCE: invention relates to production of vaccines used for an intramuscular immunization of agriculture animals against Aujeszky&#39;s disease. Vaccine is prepared by using the strain MK-25. The strain is grown in transplanted cultures of piglet or Asiatic ibex kidney cells. Obtained suspension of virus is mixed with stabilizing medium. Stabilizing medium has peptone and lactose. Vaccine is poured into ampoules and lyophilized. Activity of obtained vaccine is 10 6,75 -10 7,25  TCD 50 /ml. After a single immunization vaccine induces the expressing immunity in 100% of agriculture animals. EFFECT: enhanced effectiveness of immunization. 1 tbl, 2 ex
The invention relates to walnut oil intralipid and process for preparation, belonging to the technical field of food and drug. The formulation comprises pure walnut oil, refining lecithin, pure glycerin, caustic soda and pyrogen-free pure water. The basic preparing procedures are as follows: pure walnut oil, refining lecithin, glycerin and water are vigorously stirred into primary milk and the pH value of the primary milk is adjusted to 7.5-8.5 through little caustic soda solution, and then high-pressured and homogenized, filtered by a filter, bottled, sealed and sterilized. The walnut oil intralipid is an artificial chyle product which is prepared by simulating natural chyle granules existing in blood and can be intravenously injected as &#39;parenteral nutrient solution&#39; to rescue lives of some severe patients, (such as severely burned patients, traffic accident injured patients, patients with great operations, patients with advanced tumor and cachexia, etc.) and furthermore can be used for complementarily curing some dystrophic diseases and also can be orally taken as nutrition supplementary and auxiliary treatment. The invention can increase essential energy for body metabolism, provide biological film for body and essential &#39;polyunsaturated fatty acid&#39; for biologically active substance metabolism, and prevent and correct deficiency of essential fatty acid for body. The invention has a plurality of therapeutic functions of blood sugar reduction, anti-oxidative damage, anti-anaphylaxis, anti-cell senescence, and anti-cardiovascular hardness and the like, and provides a new direct and convenient way through which edible and medical walnut effective component can enter human body.
The invention discloses an immunity enhancement taking Japanese hop as a main ingredient. Recently, people gradually find that chemically synthesized medicaments, particularly antibiotics and the like, have toxic and side effects which causes medicament resistance and &#39;three changes&#39; (canceration, distortion and mutation) and severely threatens animal husbandry production and human beings. The invention provides the immunity enhancement taking Japanese hop as the main ingredient. The immunity enhancement comprises 80 weight parts of Japanese hop flavone and 20 weight parts of soybean flavone and consists of 5 to 30 weight parts of active ingredient, 69 to 94 weight parts of carrier and 1 weight part of surfactant, wherein the carrier is starch, anhydrous dextrose and maltodextrin; and the surfactant is lauryl sodium sulfate. The immunity enhancement taking Japanese hop as the main ingredient is applied to animals having low immunity, is used in combination with vaccine injection and can prevent and treat viral infectious diseases and bacterial infectious diseases. The immunity enhancement is an immunity enhancement taking Japanese hop as the main ingredient for the first time.
Physiologically active substances suitable as cardiac remedies are obtained from albuminous materials such as serum, blood, glands, organs (other than hearts), tanned or fresh animal skins, yeast, &amp;c., by hydrolysis at a pH of 7-10, treatment of the solution with organic water soluble solvents and, after removal of the latter in vacuo, removal of the lipoids and separation of deleterious substances by treatment with a saponifying agent. According to one example serum is mixed with dilute caustic soda and acetone and stirred for four hours, the precipitated albumen squeezed off and further extracted with acetone, the whole extract frozen and the liquid separated by filtration.  The residue, after removal of the organic solvent in a vacuum, is shaken with ether and the ethereal layer removed.  The residue is then saponified with caustic soda, neutralized and the non specific substances are removed.  Other examples describe analogous treatments of fresh skin, leather scraps and pancreas.  Specification 306,608, [Class 81 (i), Disinfecting &amp;c.], is referred to.
The invention belongs to the field of medicaments, and particularly relates to a gastrointestinal tract administration medicament for ischemic and hypoxic brain injury and application thereof in preparing medicaments for preventing and treating the ischemic and hypoxic brain injury. The gastrointestinal tract administration medicine for ischemic and hypoxic brain injury contains fisetin as main active ingredient, and further contains catalpolide. When the medicaments are used in combination, the weight ratio of fisetin to catalpolide in the medicament for gastrointestinal tract administration used for ischemic and hypoxic brain injury is as follows: 17-25 parts of fisetin and 6-12 parts of catalpol. The gastrointestinal administration for ischemic and hypoxic brain injury is preferably an oral liquid formulation so that it can be intubated in a patient&#39;s involuntary state. The medicine of the invention has certain improvement effect on the behavioral function of ischemic and hypoxic brain injury. Wherein the effect of the combination administration of the fisetin and the catalpol is better than that of the single use of the fisetin.
PURPOSE:To remarkably improve the solubility of adipic acid useful as an antiseptic agent for food, pharmaceutical, etc., by adding an alkali metal or alkaline earth metal phosphate to an aqueous system containing adipic acid. CONSTITUTION:An aqueous system containing adipic acid is prepared beforehand. Since adipic acid has low solubility in water, it is precipitated in the form of powder. The aqueous system is added with one or more kinds of alkali metal phosphate and/or alkaline earth metal phosphate (e.g. sodium phosphate, carbonate, etc.). The amount of the additive is &gt;=1mol per 1mol of adipic acid. The precipitated adipic acid is converted to a state of molecular dispersion by this treatment to increase the solubility and improved the antiseptic effect to food, etc. In the case of treating a water-containing or aqueous food or pharmaceutical, adipic acid and the above phosphate may be directly added to the food without using an aqueous system.
PURPOSE:A hair treating agent, consisting of a combination of a solution of collagen in a dilute acid and a regenerating solution of collagen fibers, and capable of imparting a strong set holding power to hair without giving chemical changes to the hair. CONSTITUTION:A hair treating agent consisting of a solution of collagen in a dilute acid containing natural collagen extracted from animal tissues with a dilute aqueous solution of an acid (&gt;=10&lt;-3&gt;M acid concentration) in an amount within 0.01-2wt% range as the first agent and a regenerating solution of collagen fibers, e.g. an aqueous solution of a water-soluble salt, pH buffer agent, e.g. partial sodium salt of citric acid, alkaline substance and protein precipitating agent, e.g. picric acid or chromic acid, as the second agent. The first and the second agents are mixed just before the treatment of the hair, and brought into contact with the washed hair in the same manner as a hair rinse agent and allowed to stand for several minutes to regenerate the collagen fibers. The hair is then lightly rinsed to remove excess water, set in a favorite hair style and dried in hot air. Thus, waves having improved water resistance, strong set holding power and good feeling are obtained.
FIELD: medicine, pharmaceutical technology, pharmacy. SUBSTANCE: composition contains roxithromycin as a therapeutically active component and the following special additions: microcrystalline cellulose, primogel, hydroxypropylcellulose and stearate. Tablet-core is covered with film-forming envelope made of mixture of hydroxypropylmethylcellulose, polyethylene glycol, glycerol, talc and titanium dioxide or of ready mixture &#34;Opadry&#34; of the firm &#34;Colorcon&#34; (USA) based on hydroxypropylmethylcellulose. Method for making tablets is carried out by wetting granulation and the following covering tablet-core with film-forming composite. Roxithromycin tablets with cover satisfy all requirements of The State Pharmacopoeia XI, they release active substance easily that provides high bioavailability of roxithromycin. Fitness time for roxithromycin tablets is above two years. EFFECT: improved preparing method, valuable pharmaceutical properties of tablets. 7 cl, 1 tbl, 5 ex
&lt;P&gt;PROBLEM TO BE SOLVED: To develop a functional feed for prophylaxis and therapy of bovine articular diseases, absorbable with high efficiency at a low cost, and for further details, the functional feed containing an amorphized chitin for cattle.  &lt;P&gt;SOLUTION: The feed, a prophylactic and therapeutic agent for the articular diseases and an antiinflammatory agent comprise the amorphized chitin. The prophylactic and therapeutic agent for the articular diseases is a cartilage destruction inhibitor or a chondrogenesis promoter. The feed, prophylactic and therapeutic agent or antiinflammatory agent is produced by using the amorphized chitin. Furthermore, the amorphized chitin, feed and prophylactic and therapeutic agent for the articular diseases are used for the therapy or prophylaxis of the bovine articular diseases. The amorphous chitin, feed and antiinflammatory agent are used for the therapy or prophylaxis of bovine inflammations. A method for treating the bovine articular diseases comprises administering the amorphized chitin, feed and prophylactic and therapeutic agent for the articular diseases.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI
A method of processing drug prescriptions via a communications network includes registering doctors, pharmacies and patients as participants such that each registered participant&#39;s identity is uniquely defined and determinable. Registered doctors from which prescriptions are received via the communications network have their identities authenticated. Each of the received prescriptions indicates a respective registered patient&#39;s identity for whom the prescription is intended. Registered patients from which orders are received via the communications network also have their identities authenticated. Each of the received orders indicates the prescription being ordered. The method also includes forwarding the orders to registered pharmacies via the communications network.
&lt;P&gt;PROBLEM TO BE SOLVED: To extract observations and a location from a diagnostic reading report written by a free format.  &lt;P&gt;SOLUTION: Sentence structure of respective sentences included in the diagnostic reading report is analyzed by a syntax analysis means 2b. Sentences including designated wordings showing objective facts in a predicate are selected by an observation determining means 2c as observation sentences. The wordings showing an object of the predicate are extracted, and they are determined by the observation determining means 2c as observation sentences. The wordings showing a location of the object of the observation sentences are extracted by a part determining means 2d, and they are determined as an observation target part. Accordingly, results showed by the observation determined by the observation determining means 2c to the observation object part determined with the part determining means 2d are outputted.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
The present invention relates to a CpG DNA, particularly to special chicken CpG ODN and use of the CpG ODN as an H5 subtype bird flu DNA vaccine adjuvant. A CpG ODN sequence is particularly 5&#39;-TTGGAACGTTCCTTTCCAACGTTGGTTTGGAACGTTCCTT-3&#39;. The H5 subtype bird flu DNA vaccine with the CpG ODN as an adjuvant is used to directly immunize chickens by means of oral taking and nose dropping. A protection rate against challenge viruses after immunity for the H5 subtype bird flu DNA vaccine can be obviously intensified. The intestinal mucous membrane IgA antibody level of immune chickens can be enhanced. The constructed DNA vaccine of the present invention has the advantages of safety, no interference of the supervision of bird flu epidemic situations after the immunity, convenient use, etc. The interference of a maternal antibody can be overcome.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for making comb-type anti-thrombotic conjugate wherein substantially all side chains of water soluble PVA are extended by ring-opening polymerization to form a copolymer wherein substantially all terminals are conjugated to an anti-thrombotic molecule.  &lt;P&gt;SOLUTION: A method for applying a coating comprising a comb-type anti-thrombotic conjugate to at least a portion of an implantable device to prevent or reduce the formation of thrombosis on the surface of the device is also provided. A first or sub-layer of the coating is prepared by mixing a polymeric material and a biologically active agent with a solvent, thereby forming a homogeneous solution. A second or outer layer comprising a comb-type anti-thrombotic conjugate may be applied over the inner drug-containing layers using a dip coating or spray coating process. The comb-type anti-thrombotic conjugate may be used as a matrix material to encapsulate a pharmaceutical agent to form microspheres or nanospheres before depositing the microspheres or nanospheres onto a medical device.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
A silica gel abrasive having good cleaning and low abrasion is prepared by combining at least two silica gels before adjusting the pH of the abrasive to a pH in the range of 3-6. One of the gels is washed at relatively lower temperature compared to the wash temperature of a second gel. The two gels are then milled and dried to a median particle size in the range of 5 to 12 microns. The volatiles content of the gel combination is in the range of 20-40% by weight. The resulting mixtures have low abrasion as measured by Einlehner, e.g., in the range of 0.5 to 3 when measured using a brass screen. A dentifrice composition comprising 10 to 25% of the abrasive has a PCR of at least 80 and can obtain PCR&#39;s greater than 100.
PURPOSE:To obtain an antimicrobial composition, excellent in antimicrobial activity and useful as various industrial materials and industrial products by subjecting metal ions of an inorganic oxo acid salt with metal ions having antimicrobial properties. CONSTITUTION:The objective substance obtained by subjecting metal ions of an inorganic oxo acid salt (e.g. magnesium metasilicate aluminate) having &lt;=2mum grain diameter to ion exchange with metal ions (e.g. Ag, Cu or Zn) having antimicrobial properties according to a conventional method, washing and drying the resultant substance. The ratio of the antimicrobial metal ions to be subjected to ion exchange is preferably 0.1-90mol% of ion exchange capacity held by the oxo acid salt. The metal ions subjected to ion exchange in the antimicrobial composition are blended in an amount of 0.01-40wt.%. If the antimicrobial composition is mixed with a resin, remarkable effects excellent in heat and chemical resistance are provided with hardly any discoloration and only slight deterioration in antimicrobial activity.
&lt;P&gt;PROBLEM TO BE SOLVED: To identify the fourth neurotrophic factor belonging to an NGF family, and to obtain a nucleic acid encoding such the factor.  &lt;P&gt;SOLUTION: The novel polypeptide, designated neurotrophic factor-4 (NT-4), has been identified by PCR amplification of human genomic DNA. Provided herein is the nucleic acid encoding the NT-4 useful in diagnostics and in the recombinant preparation of the NT-4. Also provided herein are the nucleic acids encoding naturally occurring amino acid sequence variants of the NT-4, designated NT-4β, NT-4γ, and NT-4Δ. The neurotrophic factors of the invention are useful in the treatment of nerve cells and in diagnostic assays.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT