anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
Pharmaceutical compositions for the treatment of migraine contain as at least one of the active ingredients a 6a -trifluoromethyl-17a -acyloxyprogesterone of the formula &lt;FORM:1070594/A5-A6/1&gt; wherein R is H, or an alkyl or cycloalkyl radical containing less than 7C atoms, or a 3-alkyl or cycloalkyl-enol ether thereof containing less than 6C atoms in the 3-alkyl or cycloalkyl radical, together with a carrier.  Other active ingredients which may be present include diuretics e.g. benzothiadiazine diuretics, antihistamines e.g. diphenhydramine hydrochloride, analgetics and antipyretics e.g. acetylsalicylic acid, aminopyrine, phenacetin, phnylbutazone and monophenylbutazone.  The compositions may be administered orally, parenterally, or rectally in conventional forms.
This invention provides external use lactic acid ointment, which has long cure effect, safe and without stimulation, easy acceptabel by patients for curing ichthyosis etc, xeroderma diseases. The title lactic acid ointment comprising lactic acid, proper ammonia liquor made into salt, urea as assistant osmosis agent, cholesterol etc, as emulsifier, stabilizer, antioxidant and other additional materials, is prepd, into stabal ointment of water-in-oil type. The product ointment has characters of prescription design reasonable, process mature, quality std. being able to control moduct quality, good effect during clinical practice, no toxic and stimulation and sensitive to skin. It&#39;s an effective and safe medicine for curing xeroderma etc. diseases.
FIELD: medicine. SUBSTANCE: method involves preparing the ether concentrate containing mint oil and one or some oils from the following order: fennel, caraway, anise, dill, coriander, bergamot, nutmeg-sage, rose, lavender, lemon, orange, eucalyptus and ylang-ylang oil. Oily extract of plant raw is prepared that contains wormwood herb, peppermint leaves, Saint-John&#39;s-wort herb and other wound-healing and antiseptic plant raw. Oily extract is prepared by extraction of each component or mixture in medium of organic solvent or liquid gas followed by removing the extractant. The obtained extracts were filtered, combined and diluted with food vegetable oil. Ether concentrate, oily extract and camphor were mixed at the following ratio of components, wt.-%: camphor 0.3 (not less); ether concentrate 0.3 (not less), and oily extract - the rest. EFFECT: improved method of preparing. 1 tbl
PROBLEM TO BE SOLVED: To induce the subject cells by adding an antibody against a cell surface antigen to human cells in their culturing stage, or the like, so as to utilize the subject cells in efficient and side effect-free therapeutic systems for diseases involving immune system&#39;s abnormal sthenia. SOLUTION: Antigen-specific cytotoxicity inhibitory cells are induced by adding to human cells, during or after culturing them in vitro in the presence of an antigen as a cause of e.g. an autoimmune disease such as multiple sclerosis, rheumatism or insulin-dependent diabetes, an antibody against a cell surface antigen such as anti-CD2 antibody, e.g. an antibody bindable to a segment involved in binding CD2 to LFA-3, or bindable to another segment, wherein the anti-CD2 antibody to be added is pref. anti-CD2 antibody TS2/18 or anti-CD2 antibody 35.1. Furthermore, it is preferable that cells derived from patients suffered from autoimmune diseases are cultured in vitro in the presence of an antigen and antibody thereto to produce autoimmune inhibitory cells transferable into such patients.
Disclosed is a method of obtaining selectable transgenic stem cells of a vertebrate by transfecting a male germ cell with a transfection mixture comprising a nucleic acid construct containing a transcriptional unit of a stem cell-specific promoter, for example, a cyclin A1 promotor, operatively linked to a gene encoding a fluorescent or light-emitting reporter protein. The transfection mixture is a composition for transfection, in vivo or ex vivo, of a vertebrate&#39;s male germ cells, which comprises a nucleic acid or transgene, and a gene delivery system, and optionally a protective internalizing agent, such as an endosomal lytic agent, a virus or a viral component, which is internalized by cells along with the transgene and which enhances gene transfer through the cytoplasm to the nucleus of the male germ cell. In stem cells, other than germ cells, grown in vivo, expression of the reporter gene from a cyclin A1 promoter is facilitated by preventing methylation of promoter DNA by the use of flanking insulator elements in the nucleic acid construct. Alternatively, inhibitors of DNA methylation can be used in an in vitro growth medium. A kit contains components of the transfection mixture. Selectable transgenic stem cells have stably integrated the DNA, and non-human transgenic vertebrates comprise these selectable transgenic stem cells.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents.  &lt;P&gt;SOLUTION: This invention pertains to methods, mixtures, kits and/or compositions for the determination of analytes by mass analysis using unique labeling reagents or sets of unique labeling reagents. The labeling reagents can be isomeric or isobaric and can be used to produce mixtures suitable for multiplex analysis of the labeled analytes. Analytes can be labeled by reaction of the analyte with a labeling reagent of the formula: RP-X-LK-Y-RG, or a salt thereof. Sets of isomeric or isobaric labeling reagents can be used to label the analytes of two or more different samples.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
The present invention relates to a compound &#39;Changning&#39; tablet and a preparing technology thereof. The compound &#39;Changning&#39; tablet is used for treating diseases of chronic non-specificity colonitis, irritable colon, intestine dysfunction, bacillary dysentery, enterophthisis, etc. The present invention is composed of pilose asiabell root, white atractylodes rhizome, coptis, red sage root, natural indigo, catechu, olibanum (fried), aucklandia root, borneol, chlorhexidine hydrochloride, hericiumwhite, 654-2, chlortrimeton and valium. The present invention has a preparing method that impurities are removed from the traditional Chinese medicines which are pulverized and sieved by a sieve of 120 meshes. Borneol is porphyrized for preparation, and the western medicine is porphyrized, sufficiently mixed, and sieved by a sieve of 100 meshes. The Chinese medicine and the western medicine are added with 10% of starch paste, and are sieved by a sieve of 12 meshes to make particles which are dried. Then, borneol fine powder is added for mixing, and 2% of magnesium stearate is added and uniformly mixed for making tablets. The curative effect of the medicine is good, and the side effect is slight. The present invention can be used for killing enteric bacteria, controlling infection, improving internal environment of the segmented intestine and reinforcing the autoimmunity function.
PROBLEM TO BE SOLVED: To obtain the subject cosmetic derived from a naturally occurring substance, having excellent adhesivity to the skin by making the cosmetic include a specific amount of a cellulose fine particle or a cellulose complex fine particle having a specified particle shape. SOLUTION: This cosmetic comprises 1.0-40 wt.% of a cellulose fine particle having 0.2-20 μm average particle diameter and &lt;=1.30 L/D (L is the major axis of the fine particle; D is the minor axis of the particle) and is obtained by dissolving (A) an oily raw material (e.g. palmitic acid, squalane, etc.), under heating, adding (B) a sufficiently mixed and ground pigment (e.g. talc, kaolin, etc.), granulating/drying (C) a cellulose suspension by a spray dry method, sufficiently kneading and then deaerating. The component C is obtained by dispersing one or more of an ultraviolet screening agent, a dye, a pigment, a perfume and a silica compound to the suspension according to required performances.
The invention relates to ophthalmology and can be used to cure child&#39;s and adolescent myopia. The inventive method consists in using a spiruline preparation in a quantity of 0.5-1.0 g three times per day. Said preparation is orally applied 25-20 minutes prior to meals, per os, during 1 month. A refresher course of treatment is repeated in three months. The inventive preparation improves the metabolic and immunological state of the organism, thereby stabilising the myopia, improving functions of the visual organ with respect to said pathology. The inventive method makes it possible: 1) to prevent the progression of myopia; 2) to stabilise the child&#39;s and adolescent myopia; 3) to improve the functions of the visual organ of children and adolescents.
NEW MATERIAL:A 4,5-dihydroxy-1,3-dithiolan-2-ylidenemalonic acid derivative expressed by formula I (R&lt;1&gt; and R&lt;2&gt; are lower alkyl). EXAMPLE:Diisopropyl 4,5-dihydroxy-1,3-dithiolan-2-ylidenemalonate. USE:A medicine for humans and animals, having the activating action on the hepatic function, useful as a hepatic function activator and a remedy for hepatic diseases, and usable for acute chronic hepatic diseases of the humans and animals, e.g. fatty liver, alcoholic hepatitis, hepatitis, toxic hepatic disorder, congestive liver, bile stagnatory hepatic disorder, or cirrhosis which is a terminal statue thereof. PROCESS:A dilower alkyl malonate compound expressed by formula II is reacted with CS2 in an inert solvent in the presence of a base, e.g. KOH, to form a compound expressed by formula III, which is then reacted with glyoxal and acetic acid in an inert solvent to afford the aimed compound expressed by formula I .
FIELD: medicine. SUBSTANCE: method deals with treating diseases associated with different genetic disorders obtained during patient&#39;s life or caused as a result of inherited pathology. The method deals with applying either lactoferrin (LF) and/or its conjugates as a carrier of foreign genetic information for gene therapy. At injecting laboratory animals with complexes of intact LF and plasmid DNA, containing different marker genes, genetic material penetrates tissues possessing membranous LF receptors and is expressed there. Moreover, synthesis of end products of introduced genes&#39; expression is observed in different groups of muscular fibers. Expression of marker genes in different tissues takes place, also, at injecting complexes of DNA along with LF derivatives containing either DNA-condensing polycation or DNA-condensing polycation and high-molecular polymeric carrier - dextran or phycol. Efficiency of complex-formation with LF or with its derivatives and subsequent delivery of genetic material into cells depends upon plasmid nature. Advantage of the present innovation is in the fact that the mentioned product could be used in the field of gene therapy of different human and animal diseases. EFFECT: higher efficiency. 2 cl, 3 dwg
PURPOSE:To remove noises exclusive of heart beat information and to improve the detection accuracy of the heart beats by providing a bioinformation detecting means to be embedded into a seat and vibration sensing means installed in the position different from the position of this means and determining the difference of the output signal of the both means. CONSTITUTION:A piezoelectric element 2 of the bioinformation detecting means 1 converts the various pressure changes, such as rider&#39;s heart beats applied to the embedded part, to electric signals. A filter circuit 3 filters the signals of the frequency bands corresponding to the heart beats. An amplifier circuit 4 amplifies the electric signals past the filter circuit 3 and a smoothing circuit 5 rectifies and integrates the amplified signals. A piezoelectric element 7 of the vibration sensing device 6 converts the vibrations, exclusive of the bioinformation of the rider, to electric signals. The filter circuit 8, the amplifier circuit 9 and the smoothing circuit 10 act similarly as the bioinformation detecting means 1. A subtracting means 11 subtracts the signals outputted by the vibration sensing means 6 from the signals outputted by the bioinformation detect means 1. A heart beat detecting means 12 detects the heart beat information included in the signals outputted by the subtracting means 11.
Recombinant immunotoxins are fusion proteins composed of the Fv domains of antibodies fused to bacterial or plant toxins. RFB4 (Fv)-PE38 is an immunotoxin that targets CD22 expressed on B cells and B cell malignancies. The present invention provides antibodies and antibody fragments that have improved ability to bind the CD22 antigen compared to RFB4. Immunotoxins made with the antibodies and antibody fragments of the invention have improved cytotoxicity to CD22-expressing cancer cells. Compositions that incorporate these antibodies into chimeric immunotoxin molecules that can be used in medicaments and methods for inhibiting the growth and proliferation of such cancers.; Additionally, the invention provides a method of increasing the cytotoxicity of forms of Pseudomonas exotoxin A (&#34;PE&#34;) with the mutation of a single amino acid, as well as compositions of such mutated PEs, nucleic acids encoding them, and methods for using the mutated PEs.
Novel bis-quaternary compounds of the formula &lt;FORM:1036090/C2/1&gt; wherein R1 is a halosubstituted phenyl radical, R2 and R3 are each hydrogen or a phenyl radical which may be halo-substituted, R4 is a hydrogen atom or a halosubstituted phenyl or benzyl radical, R5 is an amino or alkyl group, which may be substituted, R6 and R7 are each C1- 4 alkyl groups which may be substituted or R6 and R7 together with the nitrogen atom form a saturated heterocyclic ring which may be substituted, or R5, R6 and R7 together with the nitrogen atom form an unsaturated heterocyclic (e.g. pyridine) ring which may be substituted and A(-) is the anion of an acid yielding physiologically tolerable salts with the triamines, which may be a component of the radical R5, are prepared by reacting a reactive ester of the bis-hydroxyethylamine &lt;FORM:1036090/C2/2&gt; amine NR5R6R7.  Suitably NR5R6R7 may be a pyridinium, triethylammonium, tributylammonium, N - hydroxyethyl - N,N - diethylammonium, N - cyanomethyl - N,N - dimethylammonium, N - aminopiperidinium, N - carbethoxymethyl - N,N - diethylammonium or N - acetylaminoethyl - N,N - diethylammonium residue.  The preparation of bis chlorethylamines used as reactive ester starting materials is described.ALSO:Antibacterial preparations for technical disinfection e.g disinfection of floors or sanitary fixtures, or medicinal disinfection e.g. disinfection of the skin and of wounds, comprize a bis-quanternary compound of the formula wherein R1 is a &lt;FORM:1036090/A5-A6/1&gt; halo-substituted phenyl radical R2 and R3 are each hydrogen or a phenyl radical which may be halo-substituted, R4 is a hydrogen atom or a halo-substituted phenyl or benzyl radical, R5 is an amino or alkyl radical which may be substituted, R6 and R7 are each C1-6 alkyl groups which may be substituted for R6 and R7 together with the nitrogen atom form a saturated heterocyclic ring which may be substituted, or R5, R6 and R7 together with the nitrogen atom form an unsaturated heterocyclic (e.g. pyridine) ring which may be substituted and A\s8 is the anion of an acid yielding physiologically tolerable salts with the triamines and which may be a component of the radical R5, together with a carrier.  The preparations may suitably take the form of a solution, jelly, powder, ointment, paste, mixture requiring shaking, lincture or suspension.
NEW MATERIAL:Polysaccharide TRS having the following properties. [alpha]D&lt;29&gt;= +190.1 (1.8w/v% aqueous solution); molecular weight, 14,000+ or -3,000; sugar constitution, 70.3% glucose, 13.7% rhamnose, and rest part of uronic acid; neutral. USE:An agent to lower the blood triglyceride level and an antiarterioscelerotic agent. PREPARATION:A microbial strain belonging to Streptococcus genus [e.g. Streptococcus faecium (FERM-BP No.296), etc.] is cultured aerobically, e.g. in Rogosa medium, and centrifuged. The obtained microbial cells are suspended in physiological saline water, heated, and disintegrated with ultrasonic radiation to obtain the suspension of disintegrated cells. The suspension is defatted, centrifuged, and treated with a proteolytic enzyme such as pronase. The treated liquid is centrifuged, the supernatant liquid is added with a protein precipitator, etc. to precipitate and remove the protein fraction, and the nucleic acid component and protein component are decomposed and removed by using respective decomposition enzymes.
The invention discloses traditional Chinese medicine composition for treating laryngitis and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition for treating laryngitis comprises following ingredients including 10 grams of indigo naturalis, 10 grams of rhizoma acori graminei, 10 grams of pangolin scales, 10 grams of safflower carthamus, 10 grams of kelp, 10 grams of stiff silkworm, 10 grams of radix clematidis, 10 grams of asarum and 1000 milliliters of vinegar. The usage method includes that after being soaked into the vinegar for 30 minutes, medicine is decocted for 20 minutes, slag is removed, liquid is taken, and a patient gargles by a small quantity of medicines at a time, and gargles by the medicine for six times every day. The curative effect includes that after the medicine is taken for one to two courses of treatment, effectiveness rate achieves 96.4%. Chronic sore throat is chronic inflammation of the upper respiratory tract of the patient and is calls as &#39;deficiency fire pharyngitis&#39; in the traditional Chinese medical science. The course of the chronic sore throat is long, and the chronic sore throat needs to be treated by means of nourishing Yin and falling fire. The traditional Chinese medicine composition clears the throat of the patient so as to effect a permanent cure, detoxifies, diminishes inflammation, engenders liquid and moisten so as to take temporary solution, prevents and cures the laryngitis, removes pathogenesis and leads the patient to recover from the laryngitis.
A method of placing a ligament graft in a surgical procedure is described. A surgical system receives kinematic information related to a range of motion of a knee joint and registers one or more surfaces of a bony anatomy of the knee joint. The surgical system further generates a three-dimensional model of the knee joint. The surgical system determines a surgical plan including parameters of a graft tunnel based on the kinematic information and the three-dimensional model. A graft tunnel planning system is also described. A plurality of tracking markers are affixed to the patient&#39;s bones and a tracking unit captures their location through a range of motion of the patient&#39;s knee joint. A point probe captures the geometry of a bony surface of the patient. A computing module receives the location data and geometry data, and determines a surgical plan including parameters of a graft tunnel.
FIELD: medicine; ophthalmology.SUBSTANCE: invention relates to ophthalmology and medicine. A polymer-based eye inlay has been developed for medicine delivery by non-invasive injection into the superior or inferior fornix of eye conjunctiva. The inlay has a spherical shape and includes at least one polymer layer containing at least one medicine contained in the central core and/or dispersed in at least one polymer layer. The insert allows delayed release of at least one medicine over a release period of up to 300 days. The inlay has a symmetrical spherical shape with a diameter of 2 to 8 mm or an asymmetric spherical shape with a large radius (y) within the range of 0.5 to 4 mm and a smaller radius (y&#39;) within the range of 0.0 to 4.0 mm. The polymer layer includes a polyether, such as polycaprolactone, polylactic acid, polyhycolic acid or their copolymers, and a polyol, such as polyethylene glycol, castor oil or polyvinyl alcohol, and the polyol content in the finished mixture is from 0 to 50%. The medicine can be selected from antibiotics, antiviral, anti-allergic, anti-inflammatory, decongestants, pupil constricting agents, anticholinesterase agents, pupil dilating agents, sympathomimetic, immunological, hormonal agents, beta-adrenergic receptor blockers, growth factors, carbonic anhydrase inhibitors.EFFECT: invention provides a higher and longer medicine release.12 cl, 11 ex, 4 dwg
&lt;P&gt;PROBLEM TO BE SOLVED: To provide uniform crushable gel beads for topical delivery of biologically or cosmetically active agents in formulations such as cosmetics and pharmaceuticals.  &lt;P&gt;SOLUTION: Formulations are produced by injection of a hot gelling agent liquid into a cold moving stream of oil contained in a conduit employing a T-piece. Cold oil can be recirculated, and the beads 48 produced can be separated with a screen. Preferred beads are agar beads 48 containing an active agent retained in the bead by a restraining polymer. Desired organic solvent adjuvants can be adsorbed on oil-absorbent microspheres and included in the beads.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a health management system, an information processing unit, a health management method and a control program capable of securely contributing to the health management of a user.  &lt;P&gt;SOLUTION: In a mobile terminal, a health management information acquisition means acquires health management information, including biometric information and exercise information of the user. A health management information transmission means transmits the health management information to the information processing unit via a network. In the information processing unit, a health management information storage means stores the received health management information of the user. A meal menu information generation means generates a meal menu of the user based on the health management information. A meal supply source information supply means supplies meal supply source information corresponding to the user to the mobile terminal, based on the meal menu generated by the meal menu information generation means and the supply source information stored in the meal supply source information storage means.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
Devices for cerebral and systemic cooling via a patient&#39;s nasopharyngeal cavity are described. Cooling assemblies include at least one elongate tubular member having first and second lumens, a source of liquid coolant, a gas source communicating with the first lumen, and a switch for alternately connecting the liquid coolant source to the second lumen. The first lumen transports a compressed gas and the second lumen transports a volatile liquid. The pressurized fluid may be a perfluorocarbon. The perfluorocarbon may be perfluorohexane, perfluoropentane, or 2-methyl-perfluoropentane. The gas may be air, oxygen, or a combination.
PURPOSE: To dye keratinous fibers in intense colors by reacting a composition containing an iodine, an oxidant and an oxidation dye with a keratinous fiber in a single process. CONSTITUTION: This composition is obtained by mixing a first solution comprising a dye base (e.g. water or ethanol), an iodide (e.g. potassium iodide) and a dye precursor with a second solution comprising an oxidant (e.g. hydrogen peroxide). The dye precursor comprises a primary intermediate product (e.g. p-phenylene diamine) and a coupler (e.g. m-aminophenol). The composition is used for dyeing a keratinous fiber having extremely deep color tone, especially human hair. The composition is alkanized so as to become pH &gt;=9 and the first solution is mixed with the second solution immediately before being used for hair so as to carry out dyeing at the same time.