anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PURPOSE:To obtain a new sulfated sugar-containing polymer useful as an anticoagulant and an anticoagulative material for blood by using a polymer containing a (meth)acrylic acid derivative as a base skeleton and binding sulfated sugar to the side chain of the skeleton. CONSTITUTION:The polymer consisting of 100-1mol% polymerizable unit of formula I (A is O, NH, etc.; B is CH2, CH2CH2, etc.; R&lt;1&gt; and R&lt;2&gt; are H or 1-4C alkyl; G is sugar residue having sulfate group or its salt) and 0-99mol% copolymerizable unit, or its salt. The polymer is preferably obtained by reacting a polymer consisting of 100-1mol% unit of formula II (G&#39; is sugar residue) and 0-99mol% copolymerizable unit with a sulfating agent (e.g. chlorosulfonic acid) in a solvent (e.g. DMF). Furthermore, the raw material polymer is preferably obtained by reacting an acrylic acid derivative of formula III with an alkyl glycoside of the formula G&#39;-R (R is 1-4C alkyl) to afford the compound of formula II and polymerizing the compound of formula II and as necessary, a polymerizable monomer.
PURPOSE:To provide an antilipemic agent composed mainly of a strongly basic anion exchange resin having a polymeric quaternary salt and an imidazolium salt as functional groups. CONSTITUTION:The objective antilipemic agent contains, as a main component, a strongly basic anion exchange resin which is a copolymer of (A) the polymeric quaternary salt of formula I (R1 is H, 1-17C alkyl, etc.; R2 and R3 are H or 1- 3C alkyl; R4 is H or methyl; Y&lt;-&gt; is halogen ion, hydroxyl ion, etc.; n is integer of &gt;=1; Ar is group of formula II, formula III, etc.; X is halogen, group of formula IVor group of formula V) and (B) a polyfunctional epoxy compound having two or more oxirane rings, and containing an imidazolium salt as a functional group having a counter ion selected from halogen ion, hydroxyl ion, etc. The above ion exchange resin is free from ill odor, and has high adsorption activity to bile acid. The particle size of the agent is finer than 50 mesh, preferably 50- 325 mesh.
666,463. Hemophilus pertussis antigens. SHARP &amp; DOHME, Inc. Nov. 22, 1949 [June 28, 1949], No. 29909/49. Class 81 (i). A pertussis toxin-containing solution is detoxified by exposing it to a solution of an aliphatic alcohol having 2 to 4 carbon atoms in its molecule, the alcoholic concentration being 20 to 80 per cent by volume. According to an example, H. pertussis is grown for 48 hours at 37‹ C. on a casein hydrolysate base medium. The culture is centrifuged and the pertussis cells suspended in distilled water. The suspension is subjected to sonic oscillations and the supernatant liquid is centrifugally separated from the cell debris. The solution is cooled to 2-5‹ C. and anhydrous ethanol having a temperature of -50‹ C. is added until the alcohol concentration is 40 per cent by volume. The mixture is maintained at -10‹ C. for 24 hours. After dilution with distilled water to an alcohol concentration of 4 per cent, potash alum is added. After standing, the resulting precipitate is filtered, washed with distilled water and suspended in an isotonic phosphate buffer solution having a pH of 7.4. According to other examples ethanol is replaced by propyl, isopropyl or butyl alcohol. Specification 643,546 is referred to.
PURPOSE: To provide a milk-like food which has a protein component, such as natural whey protein, phosphate component, fats, carbohydrate and mineral materials which are respectively decreased to prescribed ratios and is low in protein and phosphorus and high in calcium content in spite of a high energy content. CONSTITUTION: This diet therapy food for renal failure patients has the decreased protein component and phosphate component and has the fats, carbohydrate and mineral materials. The protein component of this food is intrinsically formed of the natural protein obtd. from the whey. The food from the natural whey protein, the fats, such as vegetable fats, the carbohydrate, such as dextrin, and the mineral materials is composed to resemble cow&#39;s milk in terms of sensation and cooking technique and has a total energy content of 50 to 500kcal/100ml, of which 1 to 10% of the total energy content is formed of the protein component. The phosphorus component of the desired food is below 10mg/protein g. The calcium component may be incorporated into this food up to 300mg/100ml.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an additive for imparting pseudo-spa water quality to daily life water such as city water, ground water or the like which is used as bath water.  &lt;P&gt;SOLUTION: The additive for bath comprises an alkaline inorganic component and a polycarboxylic acid salt similar to those in a natural spa. As the alkaline inorganic component, any carbonate salt such as sodium hydrogen carbonate, sodium carbonate, sodium sesquicarbonate, potassium hydrogen carbonate, potassium carbonate and potassium sesquicarbonate are used as a simple substance or a mixture thereof, wherein the compounding ratio thereof is adjusted so that the pH value of the resultant mixture as a hot bath falls within the range of 9-11. In addition to the alkaline inorganic component above, a sodium or potassium salt of an organic polycarboxylic acid bearing at least two carboxy groups in one molecule is used in an amount within 0.00005-2% by weight in a water bath finally used. Thus, hot bath effects on bathing are enhanced and a spa-like feeling is attained.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a water-in-oil type emulsified cosmetic that has a high internal water phase ratio to allow good serviceability and exhibits good emulsion stability though it is a water-in-oil type solid emulsified cosmetic exhibiting good makeup sustainability and having a refreshing feeling to the skin.  &lt;P&gt;SOLUTION: The water-in-oil type emulsified cosmetic contains the following components (A), (B), (C) and (D), and satisfies the requirements (1) and (2) below. Components: (A) one or two or more selected from among glycerin monooleate, glycerine monoisostearate and polyoxyethylene glyceryl monostearate; (B) an aqueous component; (C) an oily component; and (D) a powder. Requirements: (1) The internal water phase ratio which is obtained by dividing the sum of the mass of the component (A) and the component (B), the aqueous component, by the sum of the mass of the component (A), the component (B), the aqueous component, and the component (C), the oily component, is at least 50%. (2) For the component (A), the purity of glycerine monooleate is at least 90 mass% based on the total amount of glycerin monooleate, glycerine dioleate and glycerine trioleate; the purity of glycerine monoisostearate is at least 90 mass% based on the total amount of glycerine monoisostearate, glycerine diisostearate and glycerine triisostearate; and the purity of polyoxyethylene glyceryl monostearate is at least 90 mass% based on the total amount of polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate and polyoxyethylene glyceryl tristearate.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
A device for diagnosing and treating psychiatric disorders is described. The device may be configured to provide a graphical user interface that enables a user to select at least one of: entering information related to a diagnosis of the psychiatric disorder and alleviating symptoms caused by the psychiatric disorder. Upon a user selecting entering information related to the diagnosis of a psychiatric disorder, the device may receive information related to the diagnosis of the psychiatric disorder. The device may determine the severity of a user&#39;s condition based at least in part on the received information. The device may provide a treatment based on the determined severity of the user&#39;s condition. A treatment may include providing feedback to a user.
The invention belongs to microbial medicine field, it relates to a kind of bacterial strain and application thereof producing herbimycin, is this bacterial strain through morphological specificity, cultural characteristic, physiological and biochemical property and 16S? rDNA genetic analysis, identify its be a strain streptomyces hygroscopicus (&lt;i&gt;streptomyces? hygroscopicus&lt;/i&gt;). Register on December 6th, 2013 in China General Microbiological culture presevation administrative center, deposit number: CGMCC? No.8544. In this bacterium fermented supernatant fluid after activeconstituents organic solvent extraction, through ultra-violet absorption spectrum, infrared absorption spectrum, NMR (Nuclear Magnetic Resonance) spectrum and mass spectrometric detection analysis, confirm that its activeconstituents is Herbimycin? A(Antibiotic TAN 420F), belong to benzoquinones Ansamycin, fermentation level can reach 1500 more than �� g/mL, it may be achieved industrialization, and it is convenient to extract, component is single, good product quality. Herbimycin? A has important biologic activity, can be used as organ transplantation anti-rejection drugs, has broad-spectrum weed-killing activity, has faint antibacterium and anti-mycotic activity. In addition, Herbimycin? A is inhibited to kinds of tumor cells.
An Example (7) pharmaceutical sugar dragees consisting essentially of a &#34;placebo&#34; of lactose and starch are first coated with a 10% ethanol/chloroform solution of an addition product of 2-amino-2-ethyl-1 :3-propane diol and a low molecular weight compared which is primarily the diglycidyl ether of bisphenol A, in a coating drum.  The coatings are then air dried. The dragees were finally coated with a polishing solution as above but also containing ethyl cellulose and a silicone oil. Specifications 737,310 and 811,797 are referred to.ALSO:1 mol. of an epoxy compound containing substantially 2 epoxide groups per mol is reacted with 1,125-1,5 mols of a saturated aliphatic primary monoamine containing at least two hydroxyl groups.  Long lists of suitable diepoxides are given including epoxidized dienes, epoxy esters and epoxy ethers: in the examples there are used the diglycidyl ethers of bisphenol A and hydroquinone and diglycidyl phthalate.  Similarly long lists of suitable polyhydroxy amines are given, of which the following are used in the examples: 2-amino-2-ethyl-1,3-propane diol, 2-amino-2-methyl-1,3-propane diol, and tris-(hydroxy methyl)-amino methane.  Solvents for the reaction products are mixtures of methanol or ethanol with ethylene chloride, methylene chlorides, chloroform, ethyl acetate, or acetone; and aqueous acetic acid. In Examples (7) and (8) pharmaceutical dragees and tablets are made (see Group VI) and the following compositions are disclosed: (7) A reaction product of the invention, ethyl cellulose, a silicone oil, ethyl alcohol, and chloroform, (8) A reaction product of the invention, reserpine (an alkaloid), lactose, starch, hydrolyzed starch, polyvinyl acetate, ethanol, chloroform, magnesium stearate, and talc.  At various stages of the preparation of the tablets the materials are granulated. Specifications 737,310 and 811,797 are referred to.ALSO:Medicament preparations, such as pills or tablets, for oral administration, which are water-resistant but not gastric juice-resistant, may contain or be coated with an addition product of (i) 1 mol. of a compound containing substantially 2 epoxide groups per mol., and (ii) 1.125-1.5 mols. of a saturated aliphatic primary monoamine containing at least 2 hydroxyl groups. The addition product is preferably used in the form of a solution in mixtures of alcohols containing 1 or 2 carbon atoms (e.g. methanol, ethanol) and other organic solvents such as ethylene chloride, methylene chloride, chloroform, ethyl acetate or acetone.  In Example (7) a dragee &#34;placebo&#34; consisting essentially of lactose and starch was coated with an addition product of 2-amino-2-ethyl-1 : 3-propane-diol and a low molecular weight diepoxide which is primarily the diglycidyl ether of bisphenol A.  In Example (8) a resapine-based powder was mixed with a solution containing the same addition product, and was worked up in conventional manner to form tablets.  Specifications 737,310 and 811,797 are referred to.
A method of setting up a wearable user device to allow a user to scan products and obtain product recommendations based on the user&#39;s personal biological/genetic data, using a cartridge to perform a test on the user&#39;s personal biological/genetic data via a desktop test control system into which the cartridge is plugged. A user account is associated with a cartridge ID read from the cartridge. The cartridge ID is also read using the wearable user device and passed to the server when the wearable user device is coupled to the test control system, associating the test with the user account. The test control system communicates test results to the server which analyses the test results to generate analysis results. The analysis results are then downloaded to the wearable user device. Product codes are also downloaded to the wearable user device, and stored in association with the product codes.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a cosmetic which is excellent in an action for making an active ingredient to arrive in hair to correct hair disorder caused by the changes of hydrogen bonds in the hair.  &lt;P&gt;SOLUTION: This cosmetic used for dressing hair and containing polyoxyethylenepolyoxypropylene glyceryl ether is used to correct hair disorder caused by the changes of hydrogen bonds in the hair. The average addition mole number of the oxyethylene group in the polyoxyethylenepolyoxypropylene glyceryl ether is preferably 10 to 30, more preferably 15 to 25. The average addition mole number of the oxypropylene group is preferably 10 to 30, more preferably 15 to 25. The cosmetic used for dressing the hair preferably furthermore contains a polyglycerol, a cationic polymer, and a basic amino acid.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
The present disclosure addresses this need by providing crystalline fine particle forms of PRX-3140 potassium salt, methods for preparation and the treatment for Alzheimer&#39;s disease (AD) and other dementias affecting the cholinergic and/or serotonergic systems including post-traumatic stress disorder (PTSD). In certain aspects, the present disclosure provides novel methods of preparing the compound of Formula I thereof, or PRX-3140 potassium salts, crystalline fine particle forms of PRX-3140 potassium salt, and compositions comprising them. In certain aspects, the present disclosure provides novel crystalline fine particle form of PRX-3140 potassium salt which may provide advantages including improved bioavailability and stability relative to other crystalline or amorphous forms. In other aspects, the present disclosure provides oral dosage forms of crystalline fine particle form of PRX-3140 potassium salt and excipients with improved stability. In additional aspects, the present disclosure provides novel methods of synthesizing novel crystalline fine particle form of PRX-3140 potassium salt, preparing crystalline PRX-3140 potassium salt particle delivery systems (PDS), and preparing novel final dosage forms (FDF) of crystalline fine particle PRX-3140 potassium salt. In certain aspects, the present disclosure provides novel crystalline forms of fine particle PRX-3140 potassium salt which may provide advantages including improved bioavailability and stability relative to other crystalline or amorphous forms.
The invention discloses rhodiola crenulata toner with whitening and moisturizing effects. The rhodiola crenulata toner is mainly prepared from black tea extract, rhodiola crenulata root extract, blueberry fruit extract and corresponding adjuvants. Rhodiola crenulata can nourish and moisturize skin and keep constant moisture and elasticity of the skin, has anti-oxidation and whitening functions and is called &#39;gold plant&#39; in the Compendium of Materia Medica. Blueberry is honored as a &#39;skin cosmetic taken orally&#39; and rich in anthocyanin which is a purely natural anti-aging nutrition supplement. Black tea can moisturize skin, promote blood circulation and activate cells, and also has antibacterial and refreshing functions and the like. The rhodiola crenulata toner, taking rhodiola crenulata as &#39;monarch&#39;, blueberry as &#39;minister&#39; and black tea as &#39;assistant&#39;, can promote skin metabolism, enhance activity, keep moisture, effectively contract pores, smoothen rough skin, improve skin gloss and enable the skin to become young, fine and smooth.
PROBLEM TO BE SOLVED: To obtain the subject composition useful for treating catabolic alimentary canal-related diseases including intestinal mucosa and pancreatic atrophy, intestinal hyperpermeability, host protective disorders and immunocompetence depression by including glutamine (GLN) or a functional analog of the GLN. SOLUTION: This pharmaceutical composition is obtained by including a therapeutically effective amount which is larger than that contained in a diet at normal times of GLN or a functional analog of the GLN. The resultant composition is administered to an animal. Methods for enterally administering (administering nutrients to a part of an alimentary canal between the stomach and the anus) and nonparenterally administering (administering the nutrients to a region other than the alimentary canal) are cited as the method for administering the composition. The daily dose expressed in terms of the GLN is preferably &gt;=0.3 g/kg body weight) in the case of the enteral method and preferably &gt;=0.1 g/kg body weight in the case of the parenteral method (e.g. intravenous administration).  In the case of oral administration, the GLN is preferably converted into a dry form such as an aseptic freeze-dried powder, aseptically dissolved in water and preferably mixed with other diet compositions at the time of administration.
A system for delivering a tooth whitening substance to a plurality of adjacent teeth, the delivery system comprising a strip of flexible material having a sufficient flexibility to form a curved shape on a plurality of adjacent teeth and a tooth whitening substance. The strip of material is readily conformable to the teeth surfaces and to interstitial tooth spaces without permanent deformation when the delivery system is placed thereagainst. The tooth whitening substance is applied to the strip of material such that when the delivery system is placed on the surface of the teeth, the substance contacts the surface providing an active onto the surface. The substance also provides adhesive attachment between the strip of material and the surface to hold the delivery system in place for a sufficient amount of time to allow the active to act upon the surface. The method of delivery includes pre-coating the strip of material or having the wearer apply substance to the strip of material and then applying the delivery system to the teeth surfaces. ® KIPO &amp; WIPO 2007
PCT No. PCT/JP95/00944 Sec. 371 Date Jan. 19, 1996 Sec. 102(e) Date Jan. 19, 1996 PCT Filed May 18, 1995 PCT Pub. No. WO95/32187 PCT Pub. Date Nov. 30, 1995A condensed-indan derivative represented by formula (1) and a pharmaceutically acceptable salt thereof:    &lt;IMAGE&gt;  (1)  wherein ring A represents an optionally substituted benzene ring or naphthalene ring, or a benzene ring having a lower alkylenedioxy group, ring B represents an optionally substituted benzene ring or a benzene ring having a lower alkylenedioxy group. Y represents -N=CR- or -CR=N-, R represents a -NR1R2 group, an optionally substituted nitrogen-containing heterocyclic group or a -OR3 group, wherein R1 and R2 are the same or different and each is a hydrogen atom; a phenyl group; an optionally substituted nitrogen-containing heterocyclic group; or a lower alkyl group which may be substituted by at least one selected from the group consisting of an optionally substituted amino group, a lower alkoxy group, a phenyl group, a nitrogen-containing heterocyclic group, an amine oxide group substituted by a lower alkyl group or a hydroxyl group(s); R3 represents a lower alkyl group optionally substituted by a substituted amino group, except when R represents an optionally substituted nitrogen-containing heterocyclic group; ring A and ring B are a benzene ring having no substituent group.
NEW MATERIAL:The compound of formula I (R&lt;1&gt; and R&lt;2&gt; are H, lower alkoxy or halogen; R&lt;3&gt; is H or lower alkyl; A is H, lower alkyl, etc.; n is 0-2) and its salt. EXAMPLE:2-Mercapto-4,5-diphenylimidazole-1-acetic acid ethyl ester. USE:An anti-inflammatory and analgesic agent. PREPARATION:The objective compound such as the compound of formula Ia can be produced by reacting a compound of formula II with a compound of formula III in a proper solvent in the presence of a base under heating to produce an amino ketone as an intermediate, adding a thiocyanic acid salt to the ketone and heating the mixture. The reaction solvent is e.g. methanol or ethanol.
PROBLEM TO BE SOLVED: To obtain the subject composition of an aromatic substance and a fragrance-emitting substance having high adhesivity and stability and strong smell and taste of a tropical fruit by using a specific 3-acylthiohexyl ester as an active component. SOLUTION: A 3-acyl-thiohexyl ester of the formula I (R&lt;1&gt; and R&lt;2&gt; are each H, an alkyl, furyl, thienyl or an aryl) is used as a component of the subject composition. The compound of the formula I can be used as a racemic mixture, an optically pure form, etc. Especially preferable compounds are 3- propionylthiohexyl propionate, 3-acetylthiohexyl propionate, 3-propionylthiohexyl acetate and 3-acetylthiohexyl acetate. The compound of the formula I can be produced e.g. by esterifying 3-mercaptohexanol of the formula II or 3- mercaptohexyl ester of the formula III. The composition is especially suitable as a fruit composition, fat composition, roast food, yoqurt, ice cream, cake and fruit juice composition.
The invention comprises compounds of the formula &lt;FORM:0893217/IV (b)/1&gt; (wherein R1 is hydrogen or an aliphatic or cycloaliphatic hydrocarbon radical of at most 7 carbon atoms which may be substituted by a free or alkylated hydroxyl or amino group, R3 is a hydroxyl or amino group, R4 is hydrogen or a hydrocarbon radical and R6 is a mercapto group which may be etherified by a hydrocarbon radical, which radical may be substituted by a tertiary-amino or alkoxy group) and salts thereof; and their preparation by reacting a 2-R6-4-halogen-5-X-6-R4-pyrimidine with an N-R1-hydrazine or an N-R1-N1-acyl- or -alkylidene-hydrazine, and simultaneously, or if necessary after hydrolysis of the acyl or alkylidene group, heating the reaction mixture to close the pyrazole ring, X being a free, esterified, halogenated or amidated carboxyl group or a nitrile group and, if desired, etherifying a resulting mercapto compound.  Examples are given and an extensive list of salt-forming organic and inorganic acids is provided.  Metal salts are also referred to.  2 - Alkylmercapto - 4 - chloro - 5 - cyano - pyrimidines are prepared by reacting s-alkyl-isothioureas with a -ethoxy-methylene-a -cyano-acetic acid ethyl ester to yield 2-alkylmercapto-4-hydroxy-5-cyano-pyrimidines and chlorinating these. Specifications 884,151 and 886,184 are referred to.ALSO:Pharmaceutical preparations comprise a compound of the formula &lt;FORM:0893217/VI/1&gt; (wherein R1 is hydrogen or an aliphatic or cycloaliphatic hydrocarbon radical of at most 7 carbon atoms which may be substituted by a free or alkylated hydroxyl or amino group, R3 is a hydroxyl or amino group, R4 is hydrogen or a hydrocarbon radical and R6 is a mercapto group which may be etherified by a hydrocarbon radical, which radical may be substituted by a tertiary-amino or alkoxy group) or an acid-addition or metal salt thereof, and carriers therefor.  They may take the form of tablets, dragees, solutions, suspensions or emulsions, and may contain preserving, stabilizing, wetting or emulsifying agents, and other therapeutically valuable substances. An extensive list of salt-forming organic and inorganic acids is provided.  Specifications 884,151 and 886,184 are referred to.