anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
The present invention relates to a method for preparing a sol-gel derived Si02 with a very fast bioresorption rate wherein a sol- gel derived Si02 is prepared from a sol comprising water, an alkoxide or inorganic silicate and a lower alcohol using a mineral acid or a base as a catalyst and said sol is aged and dried. Characteristic for the method is that pH is from 1.5 to 2.5, molar ratio of water to the alkoxide or inorganic silicate is 0.5 to 2.5, of alcohol to the alkoxide or inorganic silicate is &gt;= 0.5; and the sol is either let to gel without induced changes of composition and without forced drying of the sol, or a change of composition are induced; and within a time of &lt;= 30 minutes, from the induced change forced drying of the sol is carried out or initiated. The present invention also relates to a method for adjusting the bioresorption rate of sol-gel derived Si02. Characteristic for the adjusting method is that a Si02 with a very fast bioresorption rate is obtained according to the method referred to above; and a Si02 with a slower bioresorption rate than the fastest bioresorption rate is obtained by deviating any of the parameters: pH, molar ratio of water to the alkoxide or inorganic silicate and/or molar ratio of alcohol to the alkoxide or inorganic silicate; carrying out induced changes by addition of a component or components and/or optional addition of the biologically active agent or agents, said changes affecting any of the values by not carrying out forced drying, or carrying out or initiating forced drying of the sol later; and/or deviating the temperature for letting the sol gel spontaneously. The invention further relates to bioresorbable sol-gel derived Si02 obtainable by the methods of the invention and to their use in administration of biologically active agents. ® KIPO &amp; WIPO 2007
PCT No. PCT/US93/08708 Sec. 371 Date Mar. 28, 1995 Sec. 102(e) Date Mar. 28, 1995 PCT Filed Sep. 13, 1993 PCT Pub. No. WO94/06280 PCT Pub. Date Mar. 31, 1994Compositions and methods for treating a patient infected with a metazoan parasite by inhibiting the enzymatic action of the metazoan parasite protease. The compositions comprise at least one metazoan protease inhibitor which binds to the S2 subsite and at least one of the S1 and S1&#39; subsites of the metazoan parasite protease. The methods comprise administration to a patient infected with a metazoan parasite of at least one metazoan protease inhibitor in an amount effective to inhibit the protease of the metazoan parasite, thereby killing the parasite.
1392763 Adhesive composition JOHNSON &amp; JOHNSON 7 Sept 1972 [10 June 1971] 41613/72 Divided out of 1343190 Heading C1A [Also in Division C3] A filler for use in the preparation of cements using cyanoacylate binders comprises finely divided inorganic solid particles containing a basic amine actuator superimposed on a coating, on the solid particles, of a silyl compound which is non-catalytic towards the polymerization of cyanoacylates and which is triphenylsilane or a trialkoxysilyl compound having a terminal group represented by the formula where any of R, R 1  or R 2  is a methyl group or an ethyl group, the basic amine activator having a pKb. in water of 1-10 and no nitrogen having more than one attached group exceeding 5 carbon atoms. Preferred inorganic solids are quartz or alumina, and suitable amine activators are N,N-dimethyl-p-toluidine or N,N-dimethylaniline. Material for making adherent cements comprises a polymerizable binder component which is a monomeric ester of α-cyanoacrylic acid having the general formula where R is an alkyl group of 2-16 carbon atoms, a cyclohexyl or a phenyl group, and a finely divided solid filler inert with respect to the ester (e.g. as described above), and containing a basic amine activator having a pKb. in water of 1-12 and no nitrogen having more than one attached group exceeding 5 carbon atoms. The preferred filler to binder ratio is 1 part by wt. binder for 1-4 parts of filler.
The bovine milk oral albumin supplement is provided. The bovine milk oral albumin supplement includes whey protein which includes 80% to 90% w/w whey protein concentrate. The whey protein also includes 10% to 15% w/w whey protein isolate. The whey protein also includes 5% to 10% w/w whey protein hydrolysate. The bovine milk oral albumin supplement being in a powder form. The bovine milk oral albumin supplement is suitable to be consumed orally and via tube feeding, thereby avoiding painful injections to user or patient. The invention provides cost-effective oral albumin supplement using vegetarian source. The consumption of the bovine milk oral albumin supplement helps in critical conditions such as inhibits growth of cancerous cells in cancer treatment, regenerates liver cells in liver disease, supports mental health and helps in Alzheimer&#39;s and Parkinson&#39;s disease during neuro surgeries, fasten recovery of cells in burns and trauma conditions, overcomes albumin losses caused during dialysis and nephritic syndrome, and inhibits the activity of HIV Type 1 virus and enhances immunity.
This invention provides a Herpesvirus of Turkeys vaccine which comprises per dose an effective immunizing amount of a modified live Herpesvirus of Turkeys, an amount of an acemannan effective to enhance the immunogenicity of the Herpesvirus of Turkeys and a suitable carrier. This invention also provides a vaccine which comprises per dose an effective immunizing amount of a modified live virus, an amount of an acemannan effective to enhance the immunogenicity of the modified live virus and a suitable carrier. This invention further provides a vaccine which comprises per dose an effective immunizing amount of a modified live virus, an amount of a complex carbohydrate effective to enhance the immunogenicity of the modified live virus and a suitable carrier. Still further provided are a method of immunizing a chick against Marek&#39;s Disease and methods of immunizing an animal against viral disease. This invention provides a bacterin which comprises per dose an effective immunizing amount of a bacterial antigen, an amount of an acemannan effective to enhance the immunogenicity of the bacterial antigen and a suitable carrier. This invention also provides methods of immunizing an animal against bacterial disease.
The invention relates to a fatigue-resisting immunity-enhancing healthcare wine and a method for preparing the same. The fatigue-resisting immunity-enhancing healthcare wine is prepared from the following raw materials: 6-8 parts by weight of antler, 10-12 parts by weight of stiff silkworm, 8-12 parts by weight of ginseng, 10-12 parts by weight of fructus rosae laevigatae, 7-8 parts by weight of epimedium, 4-6 parts by weight of radix angelicae, 15-18 parts by weight of Chinese wolfberry fruit, 5-6 parts of clove, 10-14 parts by weight of human placenta, 8-10 parts by weight of white paeony root, 5-6 parts of saururus chinensis, 6-8 parts by weight of fructus cnidii and 1,000 parts by weight of 38-degree white wine. The raw materials are all Chinese herbal medicines which are approved by the Ministry of Health of the People&#39;s Republic of China and used for preparing healthcare food. The fatigue-resisting immunity-enhancing healthcare wine is prepared according to the theory of traditional Chinese medicine and the scientific formula by selecting and fine processing the raw materials, is natural, nutritious and delicious and can provide a variety of healthcare nutrients needed by the human body. One people is suggested to drink the healthcare wine of 30-50ml every day or a proper amount. The healthcare wine can be drunken for a long time to take the effect of enhancing the immunity of human body, resisting fatigue and strengthening bones and muscles. The healthcare wine also has the efficacy of clearing and activating channels and collaterals, soothing nerves, tonifying qi, promoting metabolism and improving the activity of organs of the human body.
A pharmaceutical composition for preventing and treating dementia, which contains a ginsenoside-F2(F2) and ginsenoside-CK as a main ingredient is provided to treat mild congnitive impairment and prevent degenerative brain diseases (Alzheimer disease, parkinson&#39;s disease, etc.). A pharmaceutical composition for preventing and treating dementia comprises a ginsenoside-F2 of the chemical formula 1 and ginsenoside-CK of the chemical formula 2 as main ingredient. In the chemical formulas 1 and 2, Glc indicates glucose. The content ratio of ginsenoside-F1 and ginsenoside-CK is 1:0.01~2. The content of the ginsenoside F2 and CK is 0.1~50 weight% based on the total weight. The amount of the composition in a health functional food is 0.01-15 weight% based on the total food weight.
PURPOSE:To obtain a preparation for nasal administration efficiently absorbing interferon from nasal mucosa, low damage of nasal mucosa tissue and high safety, containing an interferon and a sucrose fatty acid ester. CONSTITUTION:An interferon preparation for nasal administration containing an interferon (e.g. interferon alpha, interferon beta or interferon gamma) and a sucrose fatty acid ester as an absorption promoter. A sucrose fatty acid ester comprising 8-22C, especially preferably 12-18C fat component, an ester constituent component thereof is used as the sucrose fatty acid ester. The amount of the interferon blended in the preparation is about 10&lt;3&gt;-10&lt;9&gt; international unit(IU). The concentration of the sucrose fatty acid ester blended is usually 0.05w/v%-10w/v%, preferably 0.1-5.0w/v%.
&lt;P&gt;PROBLEM TO BE SOLVED: To deal with various patterns including complicated patterns and fine patterns without causing insufficient strength.  &lt;P&gt;SOLUTION: Cosmetic powder or slurry is preliminarily compacted to form a first cosmetic 3 having a prescribed shape. The first cosmetic 3 is set in a part in a cosmetic pan 2. A second cosmetic 4 that is different in color from the first cosmetic 3 and obtained by granulating cosmetic powder is packed in a packing space corresponding to a part in which the first cosmetic 3 is not present in the cosmetic pan 2. Then, the first cosmetic 3 and the second cosmetic 4 in the cosmetic pan 2 are compacted.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
A medicinal antipressor is prepared by the interaction of hippuric acid and urobilinogen or an extract containing urobilinogen. According to an example, urine of horses or other liver-bearing animals is agitated with butyl ether for several hours.  After standing two layers separate, the upper butyl ether layer containing fat &amp;c. being discarded while the lower aqueous layers is slowly evaporated at a temperature not above 170 DEG  F. to reduce its volume.  The aqueous layer is then slightly acidified p  with acetic acid and the evaporation is continued to produce a semi-fluid black mass.  The black mass is extracted with ethyl acetate, the extract being filtered and evaporated to dryness. The residue is dissolved in a mixture of alcohol and chloroform and the solution after filtering is mixed with distilled water. The resulting lower chloroform layer is evaporated to dryness to produce a urobilinogen concentrate.  The concentrate is mixed with hot water and hippuric acid, the mixture being heated until all the urobilinogen concentrate dissolves.  The hot solution is filtered and on cooling, crystals of the antipressor composition separate.  The Specification as open to inspection under Sect. 91 comprises also the preparation of an antipressor composition by reacting benzoic acid with urobilinogen or an extract containing urobilinogen.  This subject-matter does not appear in the Specification as accepted.ALSO:A medicinal anti-pressor composition is prepared by the interaction of hippuric acid and urobilinogen or an extract containing urobilinogen.  According to an example urine of horses or other liverbearing animals is agitated with butyl ether for several hours.  After standing two layers separate, the upper butyl ether layer containing fat &amp;c. being discarded while the lower aqueous layer is slowly evaporated at a temperature not above 170 DEG F. to reduce its volume.  The aqueous layer is then slightly acidified with acetic acid and the evaporation is continued to produce a semi-fluid black mass.  The black mass is extracted with ethyl acetate, the extract being filtered and evaporated to dryness, the residue is dissolved in a mixture of alcohol and chloroform and the solution after filtering is mixed with distilled water.  The resulting lower chloroform layer is evaporated to dryness to produce a urobilinogen concentrate.  The concentrate is mixed with hot water and hippuric acid, the mixture being heated until all the urobilinogen concentrate dissolves.  The hot solution is filtered and on cooling crystals of the anti-pressor composition separate.  For injection the composition may be dissolved in a solution of sodium bicarbonate, the solution being slightly warmed to eliminate generated carbon dioxide; it may also be administered orally in the dry form.  The Specification as open to inspection under Sect. 91 comprises also the preparation of an anti-pressor composition by reacting benzoic acid with urobilinogen or an extract containing urobilinogen.  This subject-matter does not appear in the Specification as accepted.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a system that automatically analyzes the part of clipped words in a document and indicates or corrects the part.  &lt;P&gt;SOLUTION: The part of clipped words is automatically analyzed and indicated in the creation of a document for which accuracy is required, such as a radiogram interpretation report. In particular, the part of the clipped words is automatically analyzed by using s-structure as a semantics structure to be obtained by LFG (Lexical Functional Grammar), and its analysis result is output. Further, processing for analyzing words to be input into the part of the clipped words and supplementing with the words and candidate word presentation are performed. These structures can reduce a load on a user and properly correct the document.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
A physical and mental health status monitor, analyze and follow up clothing system. Whose purpose is to monitor the user&#39;s body fat distribution, muscular activity and position changes to diagnose health status. Regularly giving suggestions to the user to achieve proper exercise and posture to reduce body fat and prevent muscular atrophy. While correcting the user&#39;s life style to promote better health, this system also works to reduce mental and emotional stress. Providing better healthcare and reducing the chance of disease. This system includes sensors, a close range monitoring system and long range monitoring stations, through the sensors it collects data for the monitoring system and monitoring stations to observe, analyze, diagnose and follow up on the user&#39;s physical and mental state. This system also allows the user and the long range monitoring stations to communicate with each other through the close range monitoring system.
The present invention opens the Chinese medicine composition of a kind of oral administration and externally treatment hepatitis, belongs to the technical field of Chinese herbal medicine processing.Use Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz., Channa argus, Radix Fici beecheyanae, Herba Pteridis Semipinnatae, Herba Desmodii Styracifolii, Flos Chrysanthemi, Herba Rabdosiae glaucocalycis, Folium et Cacumen Artemisiae Halodendri seed and the on-demand use of EM original solution.Channa argus removing toxic substances is reduced phlegm and internal heat, row water eliminating dampness by diuresis, the yin nourishing of strong sun, has not only had additional nutrients but also the preventing and treating of suitable hepatitis, Radix Fici beecheyanae invigorating the spleen and benefiting QI promoting blood circulation to remove obstruction in the collateral, has cured mainly expelling wind and removing dampness, and overstrain is weak, lack of appetite, invigorating the spleen and replenishing QI, is suitable for taking a tonic or nourishing food to build up one&#39;s health of icterohepatitis patient.Compatibility Ampelopsis cantoniensis （Hook. et Arn.） Planch. var. grossedentata Hand.-Mazz. is inducing diuresis and reducing edema, has the effect that anti-inflammatory and antalgic protects the liver, 3 medicine compatibilities to become the core drug of the damp and hot hepatitis for the treatment of.Medicine oral administration and externally treatment hepatitis is more beneficial for physical rehabilitation.Inexpensive, draw materials easily, the most popular.
The inventive derivatives of N,S-substitutions N&#39;-1 [(hetero)aryl] alkyl-N&#39;-[hetero) aryl] methyl isothioureas including bases and salts thereof with pharmacologically acceptable acids and individual optical isomers of said compositions or the mixtures thereof are represented by the following general formula (I):    where R?1, R2, R3¿, X,Y and Z have the values detailedly defined in the description thereof. The inventive compositions exhibit the properties of efficient neuroprotectors-blockers of the glutamate-induced transport of calcium ions. The inventive methods for producing said compositions, including stable bases and optical isomers thereof are also disclosed. The inventive physiologically active compositions of the formula (I) embodied in the form of the efficient neuroprotectors-blockers of the glutamate-induced transport of calcium ions and the method for producing a glutamatergic system with the aid thereof are also disclosed. The inventive method for curing several diseases (including Alzheimer&#39;s disease and Huntingdon&#39;s chorea) consists in prescribing to patients an efficient quantity of the formula (I) compositions. The inventive pharmaceutical compositions containing the therapeutically acceptable quantity of the composition (I) and acceptable inert auxiliary agents are also disclosed.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a powder-containing water-in-oil type emulsion cosmetic having good extensibility on the skin, excellent in emollient properties and moisture retention and duration of their effects and having no stickiness and oiliness.  &lt;P&gt;SOLUTION: The powder-containing water-in-oil type emulsion cosmetic contains an ester of a branched fatty acid with a branched alcohol. The ester is isostearyl pivalate. The cosmetic contains 0.1-30 mass% isostearyl pivalate based on the total amount of a composition. The cosmetic contains one or more species of titanium oxide, zinc oxide and cerium oxide.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a medicine bag wearing tool capable of sufficiently demonstrating medicine effects that Chinese herbs have, easily putting a medicine bag on an abdominal part or the like using a medicine bag holding body without troublesomeness or the like, and improving a wearing feeling or the like.  &lt;P&gt;SOLUTION: The medicine bag wearing tool is provided with the medicine bag 20A for housing the Chinese herbs which emit medicine effective components as a gas and the medicine bag holding body 30 for holding the medicine bag 20 in the state of being applied to the abdominal part (the navel 5 and the peripheral part). The medicine bag holding body 30 is composed of a belt-like body (band) which can be wound around the abdominal part (body part). On an inner peripheral surface side near one end part of the medicine bag holding body 30, an inner pocket 40 for housing the bag in a rectangular shape for housing the medicine bag 20 filled with the Chinese herbs, which is slightly larger than the medicine bag 20A and whose upper side part is opened is provided. On the inner peripheral surface side at the other end part of the medicine bag holding body 30, a fastener 35 for length adjustment composed of a hook-and-loop fastener for tightening and fixing the medicine bag holding body 30 matched with the length of a waistline is provided.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
The invention relates to a process and a device for preserving extracts (primary extracts) produced from Serenoa repens fruits. The preservation is carried out by treating the primary extracts in a high-pressure column with zones at various temperatures in the horizontal and vertical direction. A fractional extraction and deposition thus takes place in the column. The capric and caprylic acids which reduce the stability, and the unwanted odour and taste substances in the primary extract, are removed in a deposition vessel located outside the column. The secondary extracts obtained after the fractional extraction in the column can be kept for considerably longer than the starting materials used and are suitable as active substances for pharmaceutical and cosmetic purposes. &lt;IMAGE&gt;
PURPOSE:To safely obtain N-solanesyl-N,N&#39;-bis(3,4-dimethoxybenzyl) ethylenediamine through a short process by reaction of e.g. a solanesyl halide with a reaction product from veratraldehyde and ethylenediamine. CONSTITUTION:Firstly, a reaction is made at 10 deg.C to room temperature between a compound of formula I and ethylenediamine at a molar ratio of 2:1 in a solvent such as methanol or THF either in the presence of NaBH4 or under hydrogenation conditions using Pd catalyst to prepare a compound of formula II. Thence, this compound is reacted with a solanesyl halide or solanesyl tosylate at a molar ratio of (3-5):1 at 10 deg.C to room temperature in a solvent to obtain the objective compound of formula III. In the latter reaction, to suppress the formation of a byproduct, a compound of formula IV, it is preferable that a great excess of the compound of the formula II be used. The present compound of the formula III is useful as a medicine having carcinostatic activity- enhancing effect, carcinostatic tolerance-surmounting effect, antiviral effect, etc.
A portable system for reminding a patient and keeping track of the prescription and use of medications. The system comprises a portable unit and a software application program loaded in a PC-type computer. The portable unit consists mainly of a compact portable housing which contains an LCD display; audible alerts; pushbutton controls; battery power; and electronic circuitry to receive, store and display data. The portable unit can be programmed with dosage information regarding the particular medication, track when a particular medication has been taken, and sound an alarm when time to take another dose. The portable unit also checks for contraindications and warns of adverse reactions the patient would have with a particular drug or if a particular drug cannot be mixed with another drug presently being taken by the patient. The portable unit can receive, store, and display a patient&#39;s medical history, which can be downloaded from a PC-type computer loaded with the software application program that allows the computer to receive, store and download information regarding a patient&#39;s medical history and contraindication table. An enhancement is possible for the blind such that an audible voice informs the patient to take a particular pill number.