anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PROBLEM TO BE SOLVED: To obtain a coating solution having inhibitory effects on a foul breath for many hours, useful for teeth or artificial crowns, coloring in white or in an arbitrary color, by using both a specific resin excellent in water resistance and foul breath inhibitor or a perfume. SOLUTION: This coating solution comprises N-methacryloyloxyethyl N,N- dimethylammonium/α-N-methylcarboxybetaine/butyl methacrylate copolymer, a &lt;=4C alcohol and a deodorant, a germicide or a perfume having inhibitory effects on a foul breath. The coating solution is especially preferably obtained by blending 5-95% sthanol with 0-25% (most preferably 20-27%) of the copolymer and 0-10% of powder of a colored pigment or extender pigment. The coating solution may be mixed with chlorophyll or its derivative. The coating solution may be blended with an antienzyme such as sodium lauroylsarcosine. The coating solution may be incorporated with sodium lawrylsulfoacetate.
BACKGROUND AND PURPOSE: <p>Syringomyelia is a neurological condition in which a longitudinal fluid-filled cavity is formed within the spinal cord. It usually occurs in the cervical region and is associated with Chiari malformation, infections, trauma, and tumors of the spinal cord. However, syringomyelia associated with cervical disc disease (SCD) is very rare and only a few cases have been reported so far. This case report presents the clinical and radiological findings of 13 cases of SCD to describe the properties of SCD and explore the nature of the relationship between syringomyelia and cervical disc disease.</p>.
METHODS: <p>SCD was diagnosed in 13 using MRI findings, including coexistence of syringomyelia and cervical disc disease, presence of narrowed cervical subarachnoid space secondary to the cervical disc herniation or cervical local kyphosis associated with cervical disc degeneration or herniation, and the cervical disc herniation or segmental kyphosis and syrinx should be located within the same levels. The MRI findings were used to grade the syrinx and determine whether the cervical disc herniation or local kyphosis was located at the proximal or distal end of the syrinx.</p>.
RESULTS: <p>All patients had single-level disc herniation or kyphosis, the most common level being C5&ndash;6 (n = 6), followed by C6&ndash;7&nbsp;(n = 4) and C4&ndash;5 (n = 3). Eight patients had a distal type (disc disease located in the proximal end of the syrinx) SCD while five had the proximal variety (cervical disc disease located in the distal end of the syrinx). The average length of the syrinx was two vertebral segments. Surgery was performed in five cases and some degree of syrinx resolution was observed in all of them.<br>Discussion &ndash; The main cause of syringomyelia is obstruction of cerebrospinal fluid (CSF) pathways; total obstruction could cause distal syrinx, whereas partial obstruction could cause proximal or distal syrinxes. Restoration of CSF pathways may result in some degree of resolution of syringomyelia. A causal association may exist between cervical disc disease and cervical syringomyelia but needs further exploration.</p>.
CONCLUSION: <p>SCD is a mild form of syringomyelia with symptoms primarily arising due to disc herniation or local kyphosis. The surgical treatment of the cervical disc disease is sufficient and results in a syringomyelia resolution of some degree.</p>.
PURPOSE:To detect exactly the antibody in a sample to be inspected by an enzyme immunological measurement method, etc. in the stage of using an antigen associated to the adult T cell leukemia (ATL) to measure an ATL virus antibody by using the sample prepd. by adding the ATL virus antigen to the sample to be examined as a contrast sample. CONSTITUTION:The antigen associated to ATL obtd. by treating the MT-2 cell obtd. by the mixed culture with the leukemia cell sampled from the peripheral blood of an ATL patient with a surface active agent is conjugated at a substantial amt. to the inside surface of a cup for immunological measurement. A specified amt. of the ATL virus antigen obtd. from the MT- 2 cell cultured liquid and the serum to be inspected is added to one group (b) of the cup. Only the serum to be inspected is added to the other one group (a) and only the serum of the normal rabbit to be used for dilution of the serum to be inspected or the ATL virus antigen is added to another one group (c). After the respective groups are incubated, the ATL virus antibody labeled by enzyme, radioactivity, etc. is added to the cup to effect a reaction and then to effect the reaction of enzyme with a substrate. The coloration and radioactivity, etc. after specified time are measured and the coloration and radioactivity of the cup groups (a), (b), (c) with the substrate are measured. The rate of inhibition expressed by the formula is calculated from the measured values A, B, C thereof, and &gt;=50% rate of inhibition is determined as antibody positive and &lt;=50% rate as negative.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for identifying a domain having binding affinity for a preselected epitope.  &lt;P&gt;SOLUTION: The method for identifying a binding-site domain that retains the capacity of binding to an epitope when positioned at the C-terminal of at least one further domain in a recombinant bi- or multivalent polypeptide, is provided. A kit is also provided, comprising components such as panels of recombinant vectors of bacterial libraries transfected with recombinant vectors. Furthermore, binding site domains and fusion proteins as well as antibody-like molecules comprising such domains and proteins are provided. Besides, pharmaceutical and diagnostic compositions containing the fusion proteins and polypeptides are provided.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT
A method to optimize learning based upon ocular information of a subject includes providing a video camera for recording a close-up view of a subject&#39;s eye. A first electronic display shows a plurality of educational subject matter to the subject. A second electronic display shows an output to an instructor. Changes in ocular signals of the subject are processed through the use optimized algorithms. A cognitive state model determines a low to a high cognitive load experienced by the subject. The cognitive state model is evaluated based on the changes in the ocular signals for determining a probability of the low to the high cognitive load experienced by the subject. The probability of the low to the high cognitive load experienced by the subject is displayed to the instructor.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a set of one-pack composed of a safe, simple, convenient and effective dental cleaning agent and an applicator to remove contaminants from tooth surface.  &lt;P&gt;SOLUTION: The tooth cleaning agent and the applicator are composed of an extended shaft type tubular container 1, a tooth cleaning preparation 4 sealed in the extended shaft type tubular container 1 and a tip of the applicator 6 fixed at the end of the extended shaft type tubular container 1 in which the tooth cleaning preparation 4 containing an acid selected from the group consisting of hydrochloric acid, phosphoric acid and citrus acid is sealed. The extended shaft type tubular container 1 is a single disposable plastic container having a sealing side. A neutralizing agent of the acid may be an alkaline preparation of soda water to neutralize or simple water to dilute the acid. The set of the tooth cleaning agent and the applicator has the tooth cleaning agent, the applicator, the acid neutralizing agent and a small mirror.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
PURPOSE: To obtain an easily handleable and, comparatively stable thermocataplasm relatively mild to human body with slight side effects, high in safety, and good in preservability, by using a crude drug as medicine. CONSTITUTION: This thermocataplasm is obtained by providing one side of an exothermic element with a medicine-contg. layer of dermal tack incorporated with a medicine, i.e., a crude drug derived from a natural matter by drying a part of the natural material or being subjected to simple processing. The exothermic element is made by encapsulating an exothermic composition capable of generating heat by the presence of air, pref. comprising 40-75wt.% of iron powder, 1-10wt.% of active carbon, 1-10wt.% of a chloride, 10-40wt.% of water and 1-40wt.% of a water-holding agent in an opening-free flat bag-shaped form with at least one side representing air-permeable film. The moisture permeability of the air-permeable film is controlled to 50-600g/m&lt;2&gt; .24h determined by the ASTM (E-96-80D), its temperature on generating heat being set within the range between 38 and 43 deg.C.  For the medicinal content, it is preferable that 0.5-30 (esp. 1-15) pts.wt. of the crude drug be formulated in 100 pts.wt. of the tacky base material.
The invention belongs to the field of traditional Chinese medicines and particularly relates to an enema for treating hyperemesis gravidarum and a preparing method thereof. The enema is prepared from following traditional Chinese medicine raw materials by weight: 8-15 parts of bamboo shavings, 8-15 parts of ginger processed pinellia, 8-15 parts of dried tangerine peel, 8-15 parts of Indian bread, 10-15 parts of radix codonopsis, 5-10 parts of radix aucklandiae, 2-3 parts of villous amomum fruit, 60-100 parts of terra flava usta, 2-5 parts of liquorice root and 8-15 parts of largehead atractylodes rhizome. The enema and the method are advantageous in that traditional Chinese medicines used in the enema meet regulations of the &#39;Pharmacopoeia of China&#39; and are safe and reliable. The medicines are compatible and have functions of depressing the abnormal rising of qi, arresting vomiting, tonifying the spleen, normalizing the function of the stomach, and the like. The enema has the characteristics of a low cost, definite curative effects, rapid production of desired effects, capability of not spoiling one&#39;s appetite, simple and convenient administration, capability of being easily acceptable by patients, a high curative rate, no side effects, and the like when the enema is used for treating the hyperemesis gravidarum. The enema is particularly suitable for patients with immediately vomiting after eating and difficult in medicine taking.
This is a product/application that allows you, the consumer, to connect with personal trainers anywhere you are based on your geographical location. The product/application allows you to set your personal physical targets and goals. After the personal setup, you will be able to search your location for the personal trainer of your choosing based on the trainer&#39;s profile and user reviews of said trainers. After choosing your personal trainer, you will receive a response from your chosen trainer within three hours of selecting them; which will include a schedule session with location and length of time to confirm. Upon confirmation, your payment will be processed for the future scheduled appointment with your chosen trainer. The product/application will also allow you to create a community of like-minded individuals; be it family, friends, or found friends who are physically engaged like you are in an attempt to create your own community for inspiration and accountability. Once you, the user, registers their account, you will be able to see anyone in a geographical area to interact with in the context of your fitness targets and goals. You will be able to motivate each other through posts, emojis, shared practices, food suggestions, comments, etc.
PURPOSE:A hemostatic agent, obtained by fixing thrombin and blood coagulation factor VIII on a carrier which is fibers, etc. made from a biologically absorbable substance having a specific water absorption as a material, and having a diameter, thickness and fiber length within specific ranges, and having high hemostatic ability. CONSTITUTION:A hemostatic agent obtained by fixing thrombin and blood coagulation factor VIII on a carrier which is flakes having &lt;=5,000mu major axis, &lt;=3,000mu minor axis and &lt;=2,000mu thickness or fibers having &lt;=30 deniers fiber fineness and &lt;=10mm. fiber length, made from a biologically absorbable substance, expressed by the formula as a material, e.g. collagen. The above-mentioned hemostatic agent is most suitably used for hemostasis for hemorrhage by puncture method or after operation of biopsy to give rapid hemostatics. The hemostatis is obtained by using the above-mentioned agent after the operation even in the case in which the operation cannot be carried out due to recognized increase in the hemorrhagic tendency in a preoperative test, and the operation is possible. The agent is suitably used as an embolic material in the vascular obstruction therapy.
A system (10) is disclosed for gathering, processing, storing and reporting pharmacy data. Data from individual pharmacies is transmitted regularly to a data repository via an electronic communications network (45). Upon receipt at the data repository, the data first must pass through an access security screen (80) wherein data failing to meet predetermined criteria are rejected. If the data are determined to be valid, it is added to a data warehouse database by a computer data server (55). Authorized users may issue requests to the data repository based on current and/or historical data. Such requests may be made at any time via the electronic communications network (45) to create reports based on current data. The user first sends a request to the data repository for access. Once access to the data repository is granted, the user is able to obtain various types of information residing within the data warehouse (50). The amount and types of data available to the user may be limited by the user&#39;s predetermined security level clearance (80) and need-to-know, in order to protect patient privacy. The data may be presented to the user in a variety of predetermined report formats (90), as established by the type of data and the function of the user.
PURPOSE:To obtain a bath tone (preparation) capable of washing off the dirt exudated from the human body thoroughly, by cultivating and enzyme lipase in rice bran. CONSTITUTION:Rice bran is put into a dry sterilized vessel with a cotton plug and covered with a sheet of parchment or oiled paper, and then sterilized in a Koch steam sterilizer. An enzyme lipase is dissolved in distilled water, cast all over the resulting sterile rice bran in a thin layer with stirring, and then dried in the sun to give a bath tone (preparation). In finishing, 10g (a desert spoonful) of the resulting bath tone is placed in a cloth bag, sealed, put into water in a home bathtub and heated. Taking the bath without haste hydroluyes the dirt deposited on the whole skin by the lipase to provide a refreshing feeling, and a day&#39;s fatigue is relieved. Particularly, the good blood circulation after the bathing promotes the health.
The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase. By doing so, these compounds are effective in treating diseases associated with the dysregulation of the kynurenine pathway. A variety of diseases can be treated using these compounds and include diseases which are characterized by abnormal immune suppression, abnormal cellular proliferation and/or inflammation. In one embodiment, the disease is cancer. In another embodiment, the disease is a viral infection. In a further embodiment, the disease is depression. In a still further embodiment, the disease is Alzheimer&#39;s disease.
Detecting spatial positioning between a user&#39;s hands and an object, using a wearable device, to provide feedback to a user. Motion data of a person&#39;s body motion while performing an action can be received at a computer. The motion data can include sensor data from sensors at a location where the sensors detect the person&#39;s body motion. The sensors can include a wearable device on the person&#39;s body. The computer can be used to model the person&#39;s body motion using the motion data. A set of parameters for acceptable motions is determined based on an action risk assessment of the action. Feedback can be initiated to the person, using the wearable device, based on the person&#39;s body motion exceeding a body motion threshold based on the set of parameters for the acceptable motions and the model.
The invention relates to a universal mobile interactive information equipment that is used, in particular, to monitor a dependent elderly person.  The inventive piece of equipment is characterised in that it comprises an autonomous portable unit which can operate independently of all other communication and connection means and which can also be connected to said means.  The aforementioned portable unit comprises a carrying case containing a portable computer which manages an information system and which contains different software programs.  Access to the computer is authorised with a triple chip card reader comprising a reader for the dependent elderly person&#39;s (P.A.D.) personal card, called the patient card, a reader for the  Sesame Vitale  card and a reader for the professional health care card (C.P.S) of a person identified as a health care professional or any related card.  A numeric keypad is used to enter information and control the program(s).
PURPOSE:To simply obtain the titled medicine free from thermal decomposition in an active ingredient at a low cost, by cutting crude drugs and dried product thereof into thin piece having a specific thickness. CONSTITUTION:Crude drugs (e.g. Ginseng Radix, platycodi Radix, Cnidii Rhizoma, etc.) and dried product thereof are cut into thin piece having &lt;=0.5mm, normally about 0.1mm thickness to provide the herb medicine. For example, water content is absorbed to or heated with Ginseng Radix (e.g. commercial HAKUSAN or Ginseng Radix Rubia, etc.) which is difficult to cut into thin piece having &lt;=0.7mm even thickness and an article to be cut fixed on a belt can be cut to a prescribed thickness, by vertically moving a blade made of a superhard metal, ceramics, etc., and synchronizing the blade with the belt intermittently running toward the blade. According to the above-mentioned method, ingredient contained in the crude drug is readily extracted and filtrated without clogging because of being no powdery form.
NEW MATERIAL:The compound of formula (X&lt;-&gt; is HSO4&lt;-&gt; or H2PO4&lt;-&gt;). EXAMPLE:13-Propylberberine bisulfate. USE:Intestine conditioning agent and antidiarrhetic agent. It is highly stable, and soluble easily in water, and has excellent drug action. PREPARATION:For example, 13-propylberberine base is added with more than equimolar amount of sulfuric acid or phosphoric acid in a solvent such as methylene chloride, the components are dissolved optionally by heating, and the crystal of the objective compound is precipitated by adding a poor solvent such as ether. The starting material can be produced e.g. by converting acetoneberberine to 13-allylberberine with allyl bromide, etc., and reducing the allyl group by catalytic reduction, etc.
NEW MATERIAL:The maytansinoid compound of formulaI(one of R&lt;1&gt; and R&lt;2&gt; is OH or lower acyloxy, and the other is H; Y is H or methyl). USE:An antiprotozoal and antitumor agent having low toxicity. PROCESS:Bacterial belonging to Nocardia genus and capable of producing a maytansinoid compound of formula II (one of R1&#39; and R2&#39; is OH and the other is H),[e.g. Nocardia sp. No.N-1231 strain, IFO 13963,]etc. are cultured, and the produced and accumulated compound of formula II is separated from the cultured product. To obtain a large amount of the objective compound, the cultivation is pref. carried out in a liquid medium by submerged technique under aeration and agitation.
PURPOSE:To obtain the titled derivative having low dusting tendency and excellent redispersibility in water, economically, by preparing an oxycarboxylic acid- type cellulose derivative insoluble in water, separating into solid and liquid from a hydrated solvent solution, pulverizing in wet state, and drying the product. CONSTITUTION:The objective derivative can be produced by preparing a water- insoluble oxycarboxylic acid-type cellulose derivative (e.g. a carboxyalkyl methylcellulose, carboxyalkyl ethylcellulose, etc. having 1-5C alkyl group), separating into solid and liquid from a hydrated solvent solution (e.g. an aqueous solution of a 1-4C alkanol), pulverizing in wet state to &lt;=100mu, preferably &lt;=10mu without drying, and drying the product. USE:Effective for the preparation of a water-based enteric coating liquid.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a gastric acid secretion inhibitor in relation to the inhibition of the secretion of gastric acid in the medical field.  &lt;P&gt;SOLUTION: Objects are achieved as follows. Pastureland grass ground ivy (Glechoma hederacea var. grandis) is collected, then dried, pickled in ethanol, incubated for 3 months, mixed with rice flour, etc., changed into a semi-paste state and dipped in boiling hot water. The resultant material is dried to provide a finished product. The obtained product adjusted on the basis of 6 tablets three times a day is administered to thereby suppress the secretion of the gastric acid and dilute the gastric mucus. As a result, the growth environment of Helicobacter pylori is destroyed.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as &#39;lipophilic vehicle&#39; or &#39;LV&#39; and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. In the preferred embodiment, the formulation is a gel. The LV may contain a penetration enhancer, most preferably one with membrane disruptive properties. The formulation may be applied to or impregnated into a gauze, wrap, bandage, cotton-tipped stick, adhesive bandage strip, or other support wrap or medical bandage or wound cover. For example, the compositions may be are incorporated onto or into disposables such as hemorrhoid wipes, sponge, mouth guards, dental trays; needles or catheters; adult diapers; gloves, socks or wrist bands, for ease of application. The composition is applied topically to a site at or adjacent to a painful region. The composition is reapplied as necessary. Pain relief is typically obtained within minutes and lasts for periods of variable duration ranging from minutes to several hours and even, in some cases, days. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.