anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
PURPOSE:To obtain a skin external preparation having excellent beautiful effects, effective in prevention and improvement of blackening of skin due to sunburn and stain and ephelis and capable of using without anxiety because of its stability and safety. CONSTITUTION:The objective skin external preparation is characterized by containing (A) one or two or more kinds of extracts of plants selected from dried flower bud of Rosa rugosa var. plena Regel, dried seed of Prunus japonica Thunb. and dried fruit of Chaenomeles lagenaria Koidz. and (B) B1: N,N&#39;- diacetylcystindimethyl or B2: one or two or more kinds of extract of plants selected from seed of Coix lacryma-jobi L. var. ma-yuen Stapf, Bistorta mgior S.F. Gray var. niteus Hara, Sophora angustifolia Sieb., Sophora angustifolia Sieb. et Zucc., Crataegus cuneata Sieb. et Zucc., Humulus lupulus L., Rosa polvantha Sieb et Zucc. var. genuina Nakai and white lily.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a powdery deodorant composition exhibiting high safety and having excellent deodorant effects without adversely affecting a flavor, an aroma or a texture of chewing gum when formulated in the chewing gum by using a plant tissue body of the family Labiatae as a raw material.  &lt;P&gt;SOLUTION: The powdery deodorant composition is obtained as follows. At least one species of the plant tissue body of the family Labiatae is freed of essential oil components causing an unpleasant odor in the plant tissue body, deodorized and sterilized by a steam treatment. A polyphenol component flowing out into a steam treatment vessel residue is readded to at least the one species of the plant tissue body of the family Labiatae to provide a mixture. The resultant mixture is dried, pulverized and sieved. As a result, the powdery deodorant composition having at least 3.5 mass% of polyphenol content and a particle size wholly passing through any sieve opening ranging from 100 mesh (150 μm) to 10 mesh (11.7 mm) is prepared by seasoning, flavoring and coloring the plant tissue body of the family Labiatae prior to the drying treatment after the deodorizing and sterilizing treatments by the steam treatment of the plant tissue body of the family Labiatae.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
Model systems have shown that shifting a cell&#39;s reliance from oxidative phosphorylation (OXPHOS) to glycolysis can protect against cell death. Exploiting the therapeutic potential of this strategy, however, has been limited by the lack of clinically safe agents that remodel energy metabolism. The present invention identifies non-toxic small molecules (e.g., drug-like compounds) that are capable of modulating oxidative metabolism. One identified compound comprises meclizine. As described herein, meclizine, and its enantiomer S-meclizine, redirects OXPHOS to glycolysis. Such compounds could be protective or therapeutic in degenerative disorders such as diabetes, Huntington&#39;s, Parkinson&#39;s, and Alzheimer&#39;s disease and/or ischemic disorders including, but not limited to, stroke, heart attack, or reperfusion injuries.
PURPOSE:To control the contraction during polymerization with oxide particles and to improve the characteristic of the title sol after curing by using a reactive monomer having a polymerizable unsaturated bond as &gt;=80% of a dispersion medium to prepare the oxide sol. CONSTITUTION:The reactive monomer having a polymerizable unsaturated bond in the molecule is blown into the hydrosol of an oxide or the organosol using a nonpolymerizable org. solvent as the dispersion medium. Then water or the org. solvent is distilled under reduced pressure to substitute the dispersion medium for the reactive monomer and the oxide sol is prepared. In this case, &gt;=80% of the dispersion medium must be substituted for the reactive monomer. An ethylenic unsaturated bond is preferably used as the polymerizable unsaturated bond and acrylic acid, acrylic ester, or alpha-substituted acrylic ester are preferably used as the reactive monomer.
Predefined lists of selected variables are created and interrelated to produce incident reports. The lists are created and modified through the use of formatted computer screens or input forms, and the reports are produced through the use of formatted computer outputs or output formats. The lists include accident-related information such as industry types, occupations, safety teams, attendance codes, types of injuries, body parts affected, types of incidents, site conditions, accident causes and safety reminders. The input forms often correspond directly to the types of lists, so that there is a form through which the list of industry types is created and/or modified, and another form through which the list of occupations is created. In addition, there are input forms that allow creation and/or modification of several lists at one time, particularly when each element in one list is directly associated with one element from another list. The output formats include agency-related formats such as an OSHA (Occupational Safety &amp; Health Administration) No. 200 report, and statistical summaries used for managerial decision making. The statistical summaries may be textual or graphical, or a combination of textual and graphical.
The invention provides a kind of fast and the method for health by shell terrapin, unedible, change over and possess tortoise shell powder mixture useful taste and attractive smell, edible and extremely valuable fermentation. The present invention has retained turtle shell nutrition to greatest extent, and any stimulation that the tortoise shell powder of being manufactured by conventional method is produced reduces to minimum. In addition, the present invention has strengthened digesting and assimilating of described powder, thereby effectively improves people&#39;s health and appearance. Not yet observe any passive side effect of this product. The invention provides the various steps of the positive benefits that strengthens described powder. The present invention has broken traditional tortoise shell powder to deficiency-cold in spleen and stomach, taboo cold and that forbid without hot person.
PROBLEM TO BE SOLVED: To obtain a gray hair inhibitor excellent in effectiveness and safety by formulating a specific benzophenone derivative as an active ingredient. SOLUTION: This inhibitor contains a benzophenone derivative of formula I [R&lt;1&gt; is a bonding group of the formula: O-R&lt;2&gt; -O-G (R&lt;2&gt; is an alkylene and the like; G is H, a saccharide residue, etc.) as an active ingredient. The compound of formula I is obtained by preparing a benzophenone derivative of formula III (R&lt;3&gt; is a bonding group of the formula: O-R&lt;2&gt; -OH) by etherification from 2,4-dihydroxybenzophenone of formula II and then, for example, canying out various reactions (e.g. Koenigs-Knorr reaction and the like) used for glucosylation. It is preferable that the above-stated benzophenone derivative of formula I is formulated in an amount of 0.001-20.0 wt.% based on the whole gray hair inhibitor.
A compound comprising a target cell-specific portion and a directly or indirectly cytotoxic portion, characterised in that the target cell-specific portion recognises the target cell with high avidity. The cytotoxic portions of the compound may be a subunit of an oligomer, may contain a binding site for a small molecule, may be streptavidin, may be a dimeric ribonuclease or may be DNAse-I. The target cell-specific portion may comprise two or more binding sites for the target cell, may be an antibody or fragment thereof, or may be a ScFv. A compound suitable for cell agglutination, particularly haemagglutination. A compound comprising a mediator portion and a directly or indirectly cytotoxic portion wherein the mediator portion recognises a target cell-specific molecule and provides a means of indirect targeting. &lt;IMAGE&gt; &lt;IMAGE&gt; &lt;IMAGE&gt; &lt;IMAGE&gt;
The present invention relates to a blood fat regulating Chinese medicine composite and preparing and using methods thereof. The Chinese medicine composite has the compound and the proportioning as follows: 15 to 30% of ginkgo leaves, 15 to 25% of wild chrysanthemum flowers, 25 to 45% of milkvetch root companion and 10 to 30% of Gynostemma pentaphylla. The present invention has the preparing method that all the Chinese herbal medicines in the compound are sorted, cleaned and dried. The preparing method is characterized in that the milkvetch root is prepared into fried-with-honey milkvetch by adopting the fried-with-honey technique, and the cleaned and dried Chinese herbal medicines are treated with the superfine grinding technique and are then proportioned and packaged. The using method is characterized in that the Chinese medicine composite is carried out in tea-drinking and dietotherapy modes, the Chinese medicine composite is made and drunk by utilizing boiling water at the same time of tea drinking, and the Chinese medicine composite is made and drunk by utilizing boiling water for a few times like drinking tea; at the time of dietotherapy, the fine powder of the Chinese medicine composite is tucked in a steamed bread or put into rice for boiling, so that the Chinese medicine composite can be eaten. The product of the present invention has obvious effects of reducing blood fat, reducing blood sugar and stabilizing blood pressure so as to effectively prevent and cure thrombus diseases, such as cerebral infarction, cerebral hemorrhage, blood infarction, etc. The present invention changes people&#39;s traditional habits of taking medicine, body-building and nourishing at the time of sickness by drinking tea and dietotherapy so as to realize low price and high efficiency, and thus, the present invention is a popular health-care medicine for lengthening people&#39;s lives.
PROBLEM TO BE SOLVED: To obtain the subject cosmetic fouling neither finger nor the like, easily applicable, capable of suitably absorbing sebum and useful for improving and preventing greasiness of the sebum and messy makeup by including a specific amount of a specific oil absorbent powder. SOLUTION: This cosmetic is obtained by including 10-60 wt.% (A) oil absorbent powder having &gt;=1 ml/g squalane absorption. Especially, the component A is preferably included 15-40 wt.%. This cosmetic preferably includes additionally (B) a hydrous gel comprising (i) water-soluble polymer and (ii) a crosslinking agent. The component i is preferably formulated 1-30 wt.% especially 2-25 wt.% per whole composition. The component ii is preferably compounded 0.01-5 equivalent especially 0.1-2 equivalent per closslinkable position of the component i. The component A is preferably a porous powder having 0.005-30 μm mean particle diameter and preferably &gt;=90 wt.% component A has 0.005-30 μm particle diameter.
Extracorporeal cell-based therapeutic devices and delivery systems are disclosed which provide a method for therapeutic delivery of biologically active molecules produced by living cells in response to a dynamic physiologic environment. One embodiment includes long hollow fibers in which a layer of cells are grown within the intraluminal volume or within a double hollow-filled chamber. Another embodiment includes a wafer or a series of wafers providing a substrate onto which cells are grown. The wafer(s) are inserted into a device. A device may deliver a pre-selected molecule, for example, a hormone, into a mammal&#39;s systemic circulation and/or may deliver a member of different cell products. The device is adapted to secure viable cells which produce and secrete the pre-selected molecule into blood or fluid. The invention also provides a minimally invasive method for percutaneously introducing into a preselected blood vessel or body cavity the device of the invention.
FIELD: medicine.SUBSTANCE: invention refers to medicine, specifically urology. A method involves the complex postoperative rehabilitation. From the 10postoperative day, the patient is exposed to electric myostimulation at current intensity to pelvic floor muscle contraction, frequency 30-50 Hz, modulation depth 100% for 10-15 minutes. The therapeutic course is 12-20 daily procedures. In one month from the operation, the ischiocavernous and bulbospongiosus muscles are trained. That involves doing three exercises thinking of &#39;penis contraction&#39;. The first exercise represents 5 tensions with maximum intensity (100%), length 5 seconds and tension pauses 90 seconds. The second exercise represents 5 tensions with intensity 50% of maximum intensity, length 15 seconds and tension pauses 20 seconds. The second exercise represents 5 tensions with intensity 30% of maximum intensity, length 30 seconds and tension pauses 20 seconds. The exercises are done min. 3 times, once a week in the morning and evening. They are added with doing the interval exercises for lower extremity muscles. The exercises include 15-minute warm-up activities and doing the exercises of intensity 70-80% of maximum intensity, 50-60% of maximum heart rate, repeated for 5 times with 3-minute pauses. The exercises are done not less than 3 times. From the second postoperative month, a phosphodiesterase-5 inhibitor is administered.EFFECT: method provides improving the quality of erection ensured by erection compression of the superficial veins of penis and blood outflow blocking from the cavernous body and prolonged therapeutic effect.4 cl, 1 ex
This invention describes human parathyroid hormone analogues that have increased bone regeneration activity and increased bio-availability. The described peptides are hPTH-(1-31) formations that are cyclic, for instance, in formation of lactams or between Glu&lt;22&gt; and Lys&lt;26&gt; or between Lys&lt;26&gt; and Asp&lt;30&gt;. In addition, the natural Lys&lt;27&gt; can be substituted by Leu or other hydrophobic remnants, like Ile, norleucin, Met, Val, Ala, Trp or Phe. Usually these analogues have increased ability to stimulate adenylyl cyclase in rat osteosarcoma cells and have an increased ability to restore bone mass in female rats with their ovaries removed.  These analogues have increased activity and bio-availability, which is evident in their hypotensic effect on rats.  There is also a description of an experiment in which hypotensic activity is correlated with osteogenic activity.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a compound exhibiting excellent conglutinant effect for ectocornea injury in subocular region.  &lt;P&gt;SOLUTION: The tPA (tissue plasminogen activator) exhibits excellent ectocornea extension promoting action. The ectocornea injury is corneal ulcer, ectocornea ablation, keratitis, dry eye, keratoconjunctivitis sicca, xerophthalmia, chronic superficial keratitis, corneal erosion or prolonged corneal epithelial loss. The dosage form is an ophthalmic solution or an ophthalmic ointment. The ectocornea injury therapeutic agent is administrated orally or parenterally.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
&lt;P&gt;PROBLEM TO BE SOLVED: To provide formulations for protecting, preventing, improving or treating diseases or conditions relevant to abnormalities or low levels of n-3 or n-6 PUFA (polyunsaturated fatty acid) in blood.  &lt;P&gt;SOLUTION: Edible formulations comprise arachidonic acid (ARA). They are adapted to deliver from 150 mg to 1 g per day of ARA and may contain other PUFAs, for example docosahexaenoic acid (DHA). The DHA dosage is from 400 to 600 mg per day, and the ratio of ARA:DHA may be from 1:5 to 5:1. The formulations are pharmaceutical compositions comprising ARA and DHA at a ratio of ARA:DHA of 1:1 to 1:2, and are foodstuffs comprising 0.1 to 5% ARA. Such formulations can be used to increase ARA levels in vivo, for example in pregnant women or for people who have diseases or conditions associated with low ARA levels.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
FIELD: medicine, biotechnology. SUBSTANCE: preparation is obtained by liquid-phase culturing yeast Saccharomyces cerevisiae, enrichment yeast cells with iron and the following separation of biomass from nutrient medium. Preparation has 1-1.5% iron (as measured of dry matter content) and shows capability to normalize the level of serum blood iron and improve immune status of organism. Yeast cells are enriched with iron by addition of Mohr&#39;s salt (concentration is 1-2 mM) to nutrient medium at concentration of Mg (II) in medium 0.5-0.8 mM. To prevent pollution of biomass with substances of oxidation and hydrolysis of ions Fe (II) food gelatin at concentration 0.1-0.2% is added as a colloid stabilizing agent. Proposed preparation is an effective source of iron. EFFECT: enhanced effectiveness of preparation, absence of adverse effects. 11 cl, 3 ex, 1 tbl
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a composition, particularly a cosmetic composition, without generating phase separation or decantation and generally heterogenous composition even when using two incompatible polymers in the same composition.  &lt;P&gt;SOLUTION: A block polymer contains at least one monomer of the following formula (I) in a block having Tg of ≤20°C. In formula (I), Z preferably is COO or CONH, R&lt;SB&gt;2&lt;/SB&gt;is a divalent 1-30C group, n is an integer of 3-300, R3 is hydrogen or a 1-30C carbon-based group. The cosmetic composition contains the block polymer in a cosmetically acceptable medium. The composition is used to exhibit good adhesion for treatment of keratinous material, and good retention capacity.  &lt;P&gt;COPYRIGHT: (C)2010,JPO&amp;INPIT
Mutations in leucine-rich repeat kinase-2 (LRRK2) are the most common genetic cause of Parkinson&#39;s disease (PD). PD-associated LRRK2 mutants induce the formation of intracellular filaments which can be visualized and quantified. The invention provides cell- based screening assays and methods for identifying inhibitors of PD-associated LRRK2 mutants. Inhibitors can be identified by assessing intracellular distribution of LRRK2 protein. Identified inhibitors are potential therapeutic agents which may be useful for treating PD or other neurodegenerative disorders. The methods of the invention were used to identify 14-3-3Θ and the inhibitor of HSP90 geldanamycin, as inhibitors of LRRK2 toxicity in cells. The invention provides methods for preventing or decreasing neurotoxicity in a subject by administering a LRRK2 inhibitor.
PURPOSE:To provide the subject composition usable as a food material, or food additive, etc., containing, as active ingredient, a peptide produced by partial degradation of gelatin by a protease. CONSTITUTION:The objective composition containing, as active ingredient, a peptide &lt;=14000 in molecular weight which is produced by partial degradation of gelatin by a protease. The protease to be used is pref. a collagenase produced by microorganisms belonging to Achromobacter (esp. Achromobacter iophagus). This composition, which can be used as a medicine or food material such as for general foods, health foods, or functional foods, can also be combined with any food or medicinal materials.
The present invention is directed to compositions for noninvasively administering drugs having a sedative, analgesic, or anesthetic effect. A drug capable of absorption through mucosal tissues is incorporated into a candy matrix, which is then advantageously formed into a lollipop. A patient is put at ease when given the lollipop, and the drug rapidly enters the patient&#39;s bloodstream as the lollipop is sucked. When sedating or anesthetizing the patient, the physician can observe the patient&#39;s condition and remove the lollipop when it has had a desired effect on the patient. Alternatively, the physician can alter placement of the lollipop to slow the rate of the drug release for absorption into the patient&#39;s system. An analgesic-containing lollipop can be self-administered by a patient in response to his own subjective experience of pain and to the patient&#39;s susceptibility to the particular drug utilized.
The invention relates to an anti-human transferrin receptor human antibody and the application, which pertains to the field of molecular biology. The anti-human transferrin receptor human antibody has a single-chain antibody (scFv) amino acid sequence which is shown in a sequence table SEQ ID No.1. The anti-human transferrin receptor human antibody and the application have the advantages that: the human antibody solves the problem of immunogenicity of the target antibody, thus allowing the human antibody to carry out the long-term repeated drug administrations in the human body; the method for screening a genetic engineering antibody in a large-capacity antibody library which is adopted by the invention is easier than the monoclonal antibody preparation, the large-scale production is easy, the molecule of the antibody is small, and the antibody can enter tissues deeply, thus having obvious advantages. A pET-22b (plus) vector which is adopted by the invention contains a stronger T7 promoter, which can ensure the higher expression level of the target antibody. The induced expression conditions after the optimization can ensure that the antibody is expressed in a soluble form and the activity of protein is higher. The 3&#39; end of the pET-22b (plus) vector is provided with six His(histidine) labels, which can easily use the Ni-NTA agarose to carry out affinity chromatography and purification.
The present invention belongs to the technical field of Chinese medicine and particularly relates to an antivirus Chinese medicine preparation and a preparation method thereof. The antivirus Chinese medicine preparation comprises raw materials of dyers woad leaf, heterophylly false starwort root, weeping forsythia capsule, etc. The present invention is characterized in that the antivirus Chinese medicine preparation has the formula of 200 to 400g of dyers woad leaf, 200 to 400g of heterophylly false starwort root, 100 to 200g of weeping forsythia capsule, 100 to 200g of incised notoptetygium rhizome or root and 100 to 200g of hemlock parsley. Compared with the prior art, the present invention removes most of impurities and reduces patients&#39; dose by deeply studying the formula and precisely selecting an extraction and purification technique; the method of covering volatile oil is used for covering volatile components with heavy smell to make the extensive patients totally accept the antivirus Chinese medicine preparation. The present invention solves the defects that the past clinic medicine decoction has large prescription amount and is difficult to be manufactured into pills, capsules and tablets with small medicine loading amount. The antivirus Chinese medicine preparation has the advantages of the medicine decoction, can be rapidly absorbed by human bodies and rapidly takes effects; the antivirus Chinese medicine preparation has the advantages of precise prescription, outstanding curative effect, few but good medicinal ingredients, economy and easy acquirement, and has maximal social and economic benefit.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a cosmetic having protection effects and beautification effects on the skin and the hair by using algae of natural products as raw materials.  &lt;P&gt;SOLUTION: This cosmetic contains an alga protein, a peptide of a hydrolyzate thereof or a derivative such as an ester thereof in a usual skin cosmetic, hair cosmetic, bath medicine, or the like. Seaweeds such as Porphyra, Undaria pinnatifida, Chlorella pyrenoidosa and Spirulina are suitable as the algae, and the proteins are obtained from the algae by destroying the cell walls of the algae, e.g. by grinding, and extracting the protein therefrom with a solvent. The alga peptides are obtained by hydrolyzing the algae directly or hydrolyzing the proteins with an enzyme, an acid or an alkali, or by subjecting them to pressurized thermal extraction.  &lt;P&gt;COPYRIGHT: (C)2004,JPO&amp;NCIPI