anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a taste-concealing microcapsule composition for performing the administration of a medicine.  &lt;P&gt;SOLUTION: This composition consists of the medicine and microcapsules of a substantially water insoluble polymeric material, typically a cellulose-based polymer. The microcapsule composition can be incorporated into a medicinal blend including a chewable tablet, a foaming tablet, powder, liquid dispersion, etc. The method for concealing the taste of the medicine is also provided, and the method requires a relatively high level of a phase separated coacervation technology coated with a polymeric material. These high level coating can perform an effective taste-concealment, and since the medicine is allowed to be released for a desired objective, the medicine is released immediately after passing through mouth.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
A method for mapping functionally related brain regions of a subject. The method includes receiving a structural brain image and a dataset of resting-state functional MRI (rs-fMRI) three-dimensional (3D) image frames of a brain of the subject includes 3D image frames of the subject&#39;s brain over time. A functional connectivity map identifying groupings of functionally connected voxels is overlaid on the structural brain image. Spontaneous brain activations associated with each voxel in a grouping of functionally connected voxels are time-correlated with spontaneous brain activations in one or more other voxels in the grouping of functionally connected voxels. A reference location map for a pre-defined resting state network is generated, including reference information output. The reference location map includes brain reference locations that are informative of the one or more resting-state networks to assist a user in identifying the resting state network of the functional connectivity map.
A method is provided for producing a solid dispersion of a sparingly water-soluble medical substance comprising the step of heat treating a mixture of the sparingly water-soluble medical substance, an amorphous state-inducing agent and an amorphous state-stabilising agent using a hot air dryer, a fluidized bed dryer, a gyro-dryer or a powder dryer at a temperature of not more than the melting point of the sparingly water-soluble medical substance for 20-120 minutes whereby the sparingly water-soluble medical substance is converted to the amorphous state. &lt;??&gt;Also provided is a method for producing a solid dispersion of a sparingly water-soluble medical substance comprising the step of microwave heating a mixture of the sparingly water-soluble medical substance, an amorphous state-stabilising agent and an amorphous state-inducing agent at a frequency of 915, 2450, 5800 or 22125 MHz for 3-40 minutes whereby the medical substance is converted to the amorphous state. &lt;??&gt;These processes make it possible to make sparingly water-soluble medical substance amorphous at a temperature lower than those employed in the conventional methods. The solid dispersions of the amorphous sparingly water-soluble medical substances thus obtained have an improved mucosal or rectal absorption rate, which makes it possible to elevate their bioavailability.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a less-invasive, safe and effective sustained-release preparation which is administered through the inner ear, eye, brain or spinal cord and can be applied to human clinical settings.  &lt;P&gt;SOLUTION: The sustained-release preparation for neurotization and neuroprotection contains a neurotrophic factor or a DNA encoding the same and a bioabsorbable polymer hydrogel. Particularly, the sustained-release preparation is suitable for administration through the inner ear, eye, brain or spinal cord. Preferably, the bioabsorbable polymer hydrogel is a gelatin hydrogel. The sustained-release preparation is useful for protecting or regenerating cochlear sensory cells or spiral ganglion cells in the ear, and optic nerves, cerebrospinal nerves, or the like in the eye.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
PURPOSE: A pharmaceutical composition containing Ecklonia cava-derived phloroglucinol derivative is provided to suppress HIV-1(human immunodeficiency virus type-1) causing cell fusion without cytotoxicity. CONSTITUTION: A pharmaceutical composition for anti-HIV-1 suppression contains Ecklonia cava extract as an active ingredient. The Ecklonia cava extract is an ethanol extract. A pharmaceutical composition for anti-HIV-1 suppression contains Ecklonia cava-derived phloroglucinol derivative as an active ingredient. The phloroglucinol derivative is 6,6&#39;-bieckol of chemical formula 1. The pharmaceutical composition further contains a carrier, excipient, and diluents. A health food for anti-HIV-1 suppression contains the Ecklonia cava-derived phloroglucinol derivative as an active ingredient. The health food is used in the form of tablet, capsule, powder, granule, liquid, or pill.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide an image forming element having improved mechanical strength and other physical characteristics, and comprising a flexible thermoplastic base.  &lt;P&gt;SOLUTION: A sprayed material comprises a sprayed layered material with particles having a diameter of ≤3 μm. A practicing embodiment includes an article comprising a matrix and the sprayed layered material with a polymer particle dispersed in a medium. A producing method of these materials comprises mixing and grinding particles, and emulsifying the polymer supported in a solvent with a surfactant. As an alternative method, a producing method of a nanocomposite material comprising forming spraying agent particles by incorporating a non-dispersible emulsion polymerization monomer in a medium with a dispersible surfactant in the medium, and then producing the nanocomposite material therefrom, is disclosed.  &lt;P&gt;COPYRIGHT: (C)2004,JPO
1324618 Hemophilus gallinarum vaccine SHIONAGI &amp; CO Ltd 23 Dec 1971 [29 Dec 1970] 60111/71 Heading A5B A killed vaccine suitable for use with poultry comprises killed hemophilus gallinarum prepared by cultivation on a natural nutrient medium, inactivation and harvesting. The medium may comprise (a) poultry meat bouillon, leaf extract or potato extract, (b) sodium chloride, (c) polypeptone, casamino acid or yeast extract and (d) poultry serum, sheep serum or diphosphopyridine nucleotides. Alternatively the medium may comprise an embryonated egg. The culture may be inactivated by thimerosal, #-propiontactone, tylosin, salicylic acid, crystal violet, benzoic acid, polymyxin, gramicidin or benzethonium chloride. The vaccine may also include killed infections bronchitis virus, e.g. of the Beaudette, Massachusetts or Connecticut type, killed Newcastle disease virus, e.g. of the Sato or Miyadera type, one of the above inactivating agents as antiseptic, aluminium hydroxide gel, aluminium phosphate gel, calcium phosphate gel or an alum. The vaccine may be administered intracutaneously, subcutaneously or intramuscularly.
PROBLEM TO BE SOLVED: To obtain a dermal preparation for external use, capable of improving a rough skin and excellent in beautiful skin maintaining effect by blending a specific compound having a humidity maintaining effect and an activity of preventing a stratum corneum from a stratification with a saikosaponin extracted from a plant such as Buplenri radix. SOLUTION: This dermal preparation for external use is prepared by concurrent use of a saikosaponin with a low molecular weight betaine. As the saikosaponin, saikosaponin b1 and/or saikosaponin b2 are preferable. As the low molecular weight betaine, a quaternary ammonium salt of the formula [R&lt;1&gt; to R&lt;3&gt; are each a 1-6C alkyl; (n) is 0 or positive integer, provided that the total of the total carbon number in R&lt;1&gt; to R&lt;3&gt; and (n), is &lt;=8] is preferable. The saikosaponin is blended by 0.0001-20wt.%, especially 0.001-10wt.% based on the total amount of the dermal preparation for external use. The low molecular weight betaine is blended by 0.01-30wt.%, especially 0.1-20wt.% based on the total amount of the dermal preparation for external use.  Since this dermal preparation for external use has the excellent effects of preventing and improving skin roughness by a synergistic effect, and also humidity maintaining effect, the beautiful skin maintaining effect is obtained, and also powdery feeling in its use is suppressed.
The invention relates to the medicine, namely to psychoneurology and is intended for treating the conversion movement disorders. According to the invention, first the slow intravenous administration of Phenazepam (0.2-0.4 ml of 3% Phenazepam solution diluted to 20 ml with saline solution) is performed. As soon as the patient loses the voluntary control over the movements of the paretic limb, the suggestive therapy begins aimed at the focusing of the patient&#39;s attention upon the recovery of the movements of the affected limb. The suggestion continues until the patient falls asleep. The suggestive therapy comprises 3-5 sessions. Starting from the third day of the therapy, Ceprolex at a dose of 10 mg is prescribed for six weeks. At the same time, 8-10 session of darsonvalization is performed. On the Day 3-5, pulse psychotherapy follows.
The invention relates to a piece of water lily flower interesting handmade soap for children and manufacturing technology of the same. The handmade soap comprises effective components of natural plant oil such as water lily flower oil, tea tree oil, olive oil, coconut oil, and palm oil, and is carefully prepared by a series of processes. The handmade soap containing a low content of an alkaline component and containing a natural plant component of pigment and fragrance can nourish skin, can keep skin in normal physiological environment, and is safe and stable. The handmade soap can be manufactured by children, can be made into soaps with different kinds and colors, and has a natural and quietly elegant smell. The formula of the handmade soap can be selected according to the individual skin. The handmade soap has a full and mellow surface, is not easy to shrink and crack after storage, can be used while being manufactured, enables less moisture to be loss, and can keep a soap effect. Forced hand washing is changed into conscientious hand washing for children by using the handmade soap while children playing happily. The multi-function water lily flower interesting handmade soap for children has anti bacteria function, is suitable for children and people who suffer from skin allergy, provides fine, impact and stable foam while the soap is used, and makes the user&#39;s body feel fresh and cool.
ABSTRACT OF THE DISCLOSURE        A method of treating humans suffering from central nervous system diseases, such as Alzheimer&#39;s disease, cerebral atrophy, Parkinson&#39;s disease, senile dementia, senile tremor, essential tremor, multiple schlerosis, cerebovascular accidents, and cerebellar atrophy, as well as diseases where dementia is present.          The treatment consists of inducing into the patient&#39;s blood stream at least one from the group consisting of: sex hormones and anabolic hormones. (HGH, NCG, trophobostic hormone). Ergolid myselates, dopamine, cathecoline, serotonin, amphetamine may be used in conjunction with the hormone, as well as a vasodilator and non-steroid anti-inflammatory. Growth hormone may also be used in those patients in advanced stages of the disease, or in those patients where it has been determined that a low level o growth hormone is present, clinical deterioration not having been corrected by other hormones.        A method of diagnosing Alzheimer&#39;s disease, senile dementia, by the determination of the levels of the hormones somatotropin  (human growth hormone) and somatomedin-C (IGF-I) after the administration of the Aroonsakul-Allen provocative test. Blood-sera samples are taken every thirty minutes for a two hour period after the administration of L-Dopa, and the samples are tested for the levels of these hormones. These levels are then compared against the levels for normal subjects in the age group of between fifty years and sixty years. If the levels of the patient being diagnosed falls below the statistical mean corrected for error, then a diagnosis of Alzheimer&#39;s disease is indicated what is equivalent to severe HGH deficiency, mild and moderate, HGH deficiency indicating senile dementia in early and late stage.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method which does not act on microorganisms on a healthy skin, effectively controls proliferation of microorganisms on a skin part having reduced barrier functions, is not germicidal, does not concentrate resistant microorganisms and makes the skin healthy and to obtain an external preparation for skin used therefor.  &lt;P&gt;SOLUTION: The external preparation for skin comprises a protein that is derived from a bacterium selected from bacteria belonging the genus Lactobacillus, Bifidobacterium, Escherichia, Salmonella, Aeromonas, Streptococcus, Staphylococcus, Helicobacter, Campylobacter and Yersinia and has adhesivity to an extracellular matrix. The method for preventing adhesion of microorganisms harmful to the skin comprises using the external preparation for skin. The method for preventing proliferation of microorganisms harmful to skin comprises using the external preparation for skin. The method for producing the external preparation for skin comprising a protein having adhesivity to the extracellular matrix is provided.  &lt;P&gt;COPYRIGHT: (C)2006,JPO&amp;NCIPI
A pharmaceutical composition for intraperitoneal delivery of an anti-neoplastic agent is provided for treating cancers associated with aberrant mucin expression, preferably ovarian cancer and pancreatic, prostate, metastatic breast, bladder and lung cancers. The composition comprises nanomicelles loaded with the anti- neoplastic agent, and antibodies such as anti-MUC16, anti-MUC1 or anti-MUC4 are conjugated to these nanomicelles. The antibody-bound nanomicelles are optionally embedded in a biodegradable pH- and thermo-responsive hydrogel capable of sol- gel transition at body temperature. The pharmaceutical composition is implantable in the peritoneum, where it transforms into a semi-solid gel at the body&#39;s core temperature. In response to pH, the hydrogel swells and releases the antibody-bound nanomicelles. The nanomicelles specifically target mucin antigens on cancer cells. The anti-mucin antibodies can be internalized by the tumour cells, enabling the drug- loaded nanomicelles to gain entry and deliver the chemotherapeutic drugs inside the tumour cell.
Disclosed are guide RNAs (gRNAs) that specifically bind the 5&#39; LTR human immunodeficiency virus -1 (HIV-1) sequence comprising TTGGATGGTGCTTCAAGTTA (SEQ ID NO: 1). Disclosed are gRNAs that specifically bind the 5&#39; LTR HIV-1 sequence comprising CTACAAGGGACTTTCCGCTG (SEQ ID NO:2). Disclosed are gRNAs that specifically bind the 5&#39; LTR HIV-1 sequence comprising TCTACAAGGGACTTTCCGCT (SEQ ID NO: 3). Disclosed are nucleic acid sequences comprising a nucleic acid sequence encoding one or more gRNAs, wherein said one or more gRNAs hybridize with a target sequence in HIV-1, wherein the target sequence is selected from the group consisting of SEQ ID NO: 1, SEQ ID NO:2, and SEQ ID NO:3. Disclosed are vectors comprising a nucleic acid sequence encoding one or more gRNAs, wherein the one or more gRNA hybridizes with a target sequence in HIV-1, wherein the target sequence is selected from the group consisting of SEQ ID NO: 1, SEQ ID NO:2, and SEQ ID NO:3. Disclosed are methods for inhibiting the function of a target HIV-1 DNA sequence in a cell or removing a target HIV-1 DNA sequence from a cellular genome comprising contacting a cell comprising a cellular genome and harboring a HIV-1 genome comprising a target HIV-1 DNA sequence integrated into the cellular genome with one or more gRNAs, or nucleic acids encoding said one or more gRNAs, and a Clustered Regularly Interspaced Short Palindromic Repeats-Associated (cas) protein, or nucleic acid sequence encoding a cas protein, wherein the one or more gRNAs uniquely hybridizes with the target HIV-1 DNA sequence, wherein the target HIV-1 DNA sequence is selected from the group consisting of SEQ ID NO: 1, SEQ ID NO:2, and SEQ ID NO:3; thereby inhibiting the function or presence of the target HIV-1 DNA sequence.
PROBLEM TO BE SOLVED: To obtain a liquid formulation excellent in stability and useful for drink formulations, etc. by containing a specific ratio of a thiamin and taurine and bringing the alcohol concentration in the formulation lower than a predetermined value. SOLUTION: In this thiamin-mixed liquid formulation, the blended amount of taurine is 300-10,000 pts.wt. based on 1 pt.wt. of a thiamin such as thiamin nitrate, thiamin hydrochloride, etc., taurine is blended in 3.0-15 W/V% of total amount of the liquid formulation, and an alcohol concentration in the liquid formulation is &lt;=0.1 V/V%. It is preferable to add substantially no crude drug derived from animals in the liquid formulation and bring the pH of the formulation to 2.0-6.0.
A injection dosage form containing pure peanut oil in controlling disorders that arise in cells, or correct errors in the genetic code that cause mental, and physical disorders also in the process Mitosis cells divide, or forms identical cells, restore cells hereditary material that&#39;s scattered throughout the nucleus, restore aging, DNA restore torn tissue, muscle, alter the code and erase hundreds of inherited mental, and physical aids, deadly diseases, by enlarge cells, asthma, heart problems, child bearing, enlarge nose, lip, breast, penis, ear lobe, hearing, lungs, veins, gallstones, alter mature nerve cells, reproduce, or replace damage, or destroyed cells, replace worn out, or disease tissue, muscles, heart, cataracts, a stump of an amputated limb to re-grow. This will change the hereditary process of humans with diseases. These disorders are provided in an acceptable form. The dosage form comprises pure peanut oil which is applies in an amount that provides for a relatively period during which the composition is being excepted by a patient, but which allows substantially immediate release of the pure peanut oil after the composition has been injected. This will correct diseases that result from foreign invader organisms call pathogens, also that threaten our homeostasis-identified molecules or outer surfaces the membrane.  
     The development of DNA technology and a good function gene can be inserted into the cells of a patient, and can correct genetic defects, also give new function to the cell. This is the way type of viruses attack humans cells. The adjacent tissue this cell is the basic building block fundamental unit of the body chromosomes of cell membranes and the nucleus, cytoplasm within the cell membrane and the nucleus holds the genetic material chromosomes this will cure all defects, disorders, diseases of all kind, like cataracts and cancer.
The present invention relates to a pharmaceutical composition. The composition has a high stability and comprises an HMG-CoA reductase inhibitor (E)-3,5-dihydroxy-7-[4¦-4&#34;-fluorophenyl-2&#39;-cyclopro pyl-quinolin-3&#39;-yl]-6-heptenoic acid, or its salt or ester. The composition’s stability varies depending on its pH. The pharmaceutical composition of the present invention can be produced according to any ordinary methods employable in producing peroral solid preparations. First, NK-104, a basic substance, a vehicle, a binder and a disintegrator are mixed. Next, water is added to the resulting mixture, than granulated with stirring, dried and dressed to give dry granules. Further, the granules are mixed with a lubricant, and pelletized with a pelletizer into pellets.
PURPOSE:To obtain the titled phospholipid useful as an emulsifier and in the medical and pharmacological fields, etc., easily in high yield, using only small amount of fatty acid and catalyst, by reacting a glycerophosphorylcholine, etc. with a fatty acid and a carbodiimide condensation agent in the presence of a catalyst. CONSTITUTION:The objective phospholipid of formula II can be prepared according to the reaction formula, by reacting (A) glycero-phosphorylcholine of formula I or its salt with (B) a fatty acid of formula RCOOH (R is aliphatic chain) and (C) a carbodiimide condensation agent [e.g. N, N&#39;-dicyclohexylcarbodiimide (DCC), etc.] in the presence of a catalyst [e.g. 4-dimethylaminopyridine (DMAP)] in anhydrous solvent such as dichloromethane, usually at normal temperature for 6-72hr under stirring. The amount of the component C is &gt;=1 mol per 1 mol of the component B. The component B is preferably a 10-24C fatty acid such as palmitic acid, and if necessary, a fatty acid having polymerizable group. The condensation agent may be added at a proper stage during the reaction.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a fermented liquid of tomato capable of rapidly exhibiting hypotensive action, having good flavor and taste, capable of being easily taken continuously for a long period, to provide a hypotensive agent, to provide an eating and drinking composition, and to provide food and drink.  &lt;P&gt;SOLUTION: This hypotensive agent contains the fermented liquid of the tomato. A method for using the hypotensive agent comprises taking the hypotensive agent in an amount of 0.4-2.5 g per day converted into acetic acid. A method for producing the hypotensive agent includes a fermentation process in which a processed liquid of the tomato is at least subjected to acetic acid fermentation. The food and drink contain the fermented liquid of the tomato. The eating and drinking composition contains the fermented liquid of the tomato, at least any one of an edible organic acid and its salt, and sugar alcohol.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a scanning suspension comprising a particle having a diameter of at least 1 μm and capable of disturbing a magnetic field at least partly, and the use thereof for obtaining a scanning image.  &lt;P&gt;SOLUTION: Preferably, the particle comprises holmium and a composition capable of essentially maintaining its structure during irradiation. The particle is suitable for preparing a kit of parts, comprising a diagnostic composition and a therapeutic composition, both of which comprise the particles with essentially the same chemical structure, wherein the therapeutic composition is more radioactive than the diagnostic composition. The kit of parts is especially suitable for treatment of tumor. Firstly, the distribution of the particles within an individual can be determined with a scanning image obtained with a scanning composition. Subsequently, a radioactive therapeutic composition can be administered, wherein a suitable dose of the therapeutic composition is derived from the scanning image.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To protect the privacy of a patient without impairing the efficient operation environment of a doctor.  &lt;P&gt;SOLUTION: A medical examination support device manages inspection information. An inspection list display screen 36 is displayed on the monitor. On the inspection list display screen 36, personal information such as a patient name, birth date, sex, and address and inspection information including such items as inspection dates, inspection classifications, and inspection progress circumstances are displayed in a list for every inspection. This medical examination inspection support device is linked with an electronic medical record device. When the medical record information is displayed on the monitor, this electronic medical record device transmits a trigger signal as well as patient ID corresponding to the medical record information to the medical examination support device. When receiving the trigger signal while this inspection list is displayed, the medical inspection support device sets the personal information of any patient other than the designated patient in a non-display state.  &lt;P&gt;COPYRIGHT: (C)2009,JPO&amp;INPIT