anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a cell therapy method for treating tumors.  &lt;P&gt;SOLUTION: Artificial antigen presenting cells [AAPC; (Drosophila melanogaster)] transfected with human HLA class I and defined accessory molecules are used to stimulate CD8+T cells from both normal donors and cancer patients. The class I molecules expressed to a high density on the surface of the Drosophila cells are empty, and allow for efficient addition of a plurality of peptides that brings the generation of polyclonal responses recognizing tumor cells endogenously expressing the specific peptides. The generated responses are robust, antigen-specific and reproducible when the peptide epitope is a defined immunogen. The artificial antigen expression system can be adapted to treat most cancers in a significant majority of the population.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
The present invention relates to a method for preparing digestion-promoting spleen-invigorating soymilk powder with micron chicken&#39;s gizzard-skin powder, micro coix seed powder, micron white hyacinth bean powder, micron yam powder and micron pine pollen. The digestion-promoting spleen-invigorating soymilk powder is formed by that the micron chicken&#39;s gizzard-skin powder, the micro coix seed powder, the micron white hyacinth bean powder, the micron yam powder, the micron pine pollen and oligosaccharide raw material through high-technology airflow superfine grinding processing are added into different soymilk powder and combined and processed. The digestion-promoting spleen-invigorating soymilk powder has the obvious functions of promoting digestion and invigorating spleens and also has the effects of alloying fatigue, enhancing immunity, etc. The old, the middle-aged and the young with spleen deficiency and general deficiency can obtain scores of nutrient substances such as abundant protein, vitamins, mineral substances, active ferment, etc., and the digestion-promoting spleen-invigorating soymilk powder simultaneously strengthens the health-care functions of promoting digestion, invigorating spleens, alloying fatigue, regulating immunity, reducing blood fat, etc. because the ingredient of the pine pollen which is extolled as a Chinese special product and a miniature nutrient treasury is added. Therefore, the present invention is a favorable method for preparing the digestion-promoting spleen-invigorating soymilk powder which has Chinese characteristics and is especially designed for the old, the middle-aged and the young with incoordination between spleens and stomachs, constitutional deficiency, indigestion or poor appetite all over the world.
NEW MATERIAL:A clavulone derivative expressed by formula I [R&lt;1&gt; and R&lt;2&gt; are H or lower alkanoyl; X is -CH2OR&lt;3&gt; (R&lt;3&gt; is H or lower alkanoyl) or formula II (R&lt;4&gt; and R&lt;5&gt; are H, lower alkyl or lower alkoxycarbonyl)]. EXAMPLE:A compound expressed by formula III. USE:The above-mentioned dervative has antitumor action and is useful as an antitumor agent. PREPARATION:A compound expressed by formula IV is e.g. reduced with sodium borohydride in the presence of cerium chloride and then a protecting group is introduced into the reaction product to afford a compound expressed by formula V, which is then reduced in the next process and acetylated and successively a protecting group is removed to give a compound expressed by formula VI. The resultant alcohol expressed by formula VI is oxidized using an oxidizing agent, preferably pyridinium chlorochromate to provide the compound expressed by formula VII (Ac is acetyl) among formula I.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide multiphase personal washing bars having artisan-crafted appearance.  &lt;P&gt;SOLUTION: In such bars the hardness of a discontinuous phase is greater than 2 times the hardness of a continuous phase. A manufacturing method of these by a high speed extrusion process comprises extruding a composition e.g. at least about 200 bars/minute, preferably in excess of 300 bars/minute. The bars made by the method comprise a discontinuous phase having its longest dimension between about 3 and about 75 mm that is dispersed in a continuous phase containing a cleansing base.  &lt;P&gt;COPYRIGHT: (C)2011,JPO&amp;INPIT
The present disclosure describes a novel therapeutic apheresis system and, more specifically, methods and an apparatus for performing therapeutic apheresis. The present disclosure provides highly efficient methods for therapeutic apheresis that modulate the immune system, thereby resulting in treatment of one or more underlying immunological disease processes. In some embodiments, the disclosed methods return at least a portion of blood from an extracorporeal circuit to a patient in pulsatile flow, where the portion of blood that is returned is augmented. In other embodiments, the disclosed methods and apparatus use the central arterial system to exchange volumes of plasma to immunomodulate disease processes. The disclosed methods combine concepts of intermittent flow and continuous flow therapeutic apheresis with established cardiovascular concepts. In addition, the disclosed methods reduce the amount of time spent by patients in therapeutic apheresis sessions and decrease patients&#39; dependence on immunological drugs that may have detrimental adverse effects.
PURPOSE:To produce a beauty lotion, by mixing refined water with honey, muscovado, and lemon juice to obtain a stock solution, separately preparing a natural activated granular enzyme from a medium composed of the juice of natural fruit, glucose, and starch, adding the enzyme to the stock solution, and filtering and recovering the mixture. CONSTITUTION:Refined water is mixed with honey, muscovado and lemon juice and heated until the mixture reaches the boiling point, when the heat source is removed and the mixture is maintained at &lt;=60 deg.C to obtain the stock solution of the beauty lotion. Separately, fruit juice extracted from a natural fruit (e.g. papaya, apple, etc.) is mixed and kneaded with glucose and starch at a ratio of 10:1, and the obtained culture medium is fermented and dried to obtain a natural activated granular enzyme. The stock solution is added with the enzyme, maintained at &lt;=60 deg.C, and filtered to obtain the objective beauty lotion. The beauty lotion is effective to keep smoothness, fairness and elasticity of the skin by the synergistic effect of the stock solution to protect and grow the skin and the enzyme to promote the metabolism.
PCT No. PCT/FR94/00914 Sec. 371 Date Mar. 6, 1996 Sec. 102(e) Date Mar. 6, 1996 PCT Filed Jul. 21, 1994 PCT Pub. No. WO95/03272 PCT Pub. Date Feb. 2, 1995The present invention relates to novel organic products resulting, for example, from the condensation of a dicarboxylic acid with a sulfur-containing amino acid or one of its derivatives. These products contain reactive thiol SH functions which can be oxidized to form disulfide bridges, resulting in polymers, which may or may not be crosslinked. These novel organic products correspond to the following formula:    &lt;IMAGE&gt;  (I)  The invention also relates to the polymers and/or networks deriving from the products of formula (I) and to one of the methods for obtaining these products and their derivatives. Applications as biomaterials: sutures, ligatures, prostheses, adhesives or systems for the controlled release of active principles.
The system described herein enables clinicians and researchers to use aggregated genetic and phenotypic data from clinical trials and medical records to make the safest, most effective treatment decisions for each patient. This involves (i) the creation of a standardized ontology for genetic, phenotypic, clinical, pharmacokinetic, pharmacodynamic and other data sets, (ii) the creation of a translation engine to integrate heterogeneous data sets into a database using the standardized ontology, and (iii) the development of statistical methods to perform data validation and outcome prediction with the integrated data. The system is designed to interface with patient electronic medical records (EMRs) in hospitals and laboratories to extract a particular patient&#39;s relevant data. The system may also be used in the context of generating phenotypic predictions and enhanced medical laboratory reports for treating clinicians. The system may also be used in the context of leveraging the huge amount of data created in medical and pharmaceutical clinical trials. The ontology and validation rules are designed to be flexible so as to accommodate a disparate set of clients. The system is also designed to be flexible so that it can change to accommodate scientific progress and remain optimally configured.
FIELD: medicine, gastroenterology, phytotherapy, parapharmaceutical industry. SUBSTANCE: preparation for prophylaxis and accessory therapy in treatment of gastritis, duodenitis and colitis comprises milfoil leaves infusion dry concentrate, matricary flowers infusion dry concentrate, peppermint tincture dry concentrate, sea-buckthorn fruits syrup dry concentrate, dioecious nettle leaves extract dry concentrate, fenestrate Saint-John&#39;s-wort herb tincture dry concentrate and also starch, wheat bran, calcium state and sugar. Supplement shows the general tonic effect on function of alimentary tract. Invention can be used for prophylaxis and treatment of gastritis, duodenitis and colitis of different etiology. EFFECT: valuable medicinal properties of supplement. 1 tbl, 4 ex
As described herein, a system includes an optical sensor, and a controller that detects progression of obstructive coronary artery disease using a sensor signal from the optical sensor. For example, the system is used for detecting an occlusion in a cardiovascular system of a user. A computer-implemented method for detecting the occlusion includes generating a light within a predetermined spectral range, the light directed towards a reflective element at a predetermined angle. The method further includes receiving a reflected light caused by a reflection of the light off of a reflecting element that is in contact with the user&#39;s epidermis. The method further includes detecting a concentration of a predetermined biomarker in a biofluid in the cardiovascular system based on variations in amplitude of the reflected light. The method further includes determining an occlusion in the cardiovascular system based on the concentration of the predetermined biomarker.
A gold salt of a mercapto compound in which two molecules of the mercapto compound is combined with one atom of gold, is prepared by mixing a solution of an ionizable gold compound with a dimercapto compound to form a soluble product at a pH of at least 7, and preferably 9 to 11.  The gold compound may be isolated by evaporating the gold solution to dryness in vacuo and extracting the gold compound from the solid so formed with acetone. Preferred dimercapto compounds are 2,3-dimercaptopropanol and 2,3-dimercaptopropionic acid; other suitable dithiols are 2,3-dimercapto ethyl ether, aromatic o-dithiols, especially phenyl ethane dithiol-1,2 and 1,2-dimercapto-benzene, and aliphatic dithiols which contain at least three carbon atoms and have the -SH attached to vicinal carbon atoms. The gold mercapto compound is soluble in water, methanol, ethanol, acetone, propylene glycol and methyl acetamide.  The Specification as open to inspection under Sect. 91 comprises also gold salts of aliphatic dithiols of general formula &lt;FORM:0662015/IV (b)/1&gt; p where R=aliphatic chain of up to 17 carbon atoms; Z=-OH, -COOH, -COO alkyl, -CH3 or a glucose radical.  This subject-matter does not appear in the Specification as accepted.
The invention provides a composition for treating and preventing Alzheimer&#39;s diseases, which consists of monacolins, an anti-inflammatory agent and an antioxidant according to a specific weight ratio, wherein the monacolins, the anti-inflammatory agent and the antioxidant are extracted from fermented red yeast rice, and the fermented red yeast rice is prepared from Oryzasati VaL. (Japonica) serving as a raw material by an appropriate controlled fermentation process. The invention further provides a preparation method of the composition for treating and preventing Alzheimer&#39;s diseases. The Oryzasati VaL. can be fermented into the fermented red yeast rice by the appropriate controlled fermentation process, and the fermented red yeast rice is ground and then used as the composition for treating and preventing Alzheimer&#39;s diseases. According to the composition for treating and preventing Alzheimer&#39;s diseases and the preparation method thereof, the composition consisting of the monacolins, the anti-inflammatory agent and the antioxidant has the effect of treating and preventing Alzheimer&#39;s diseases.
501,496. Liver extracts. KEIL, H. L. June 29, 1938, No. 19250. [Class 81 (i)] Liver extracts are freed from impurities, in particular from small amounts of proteins, glycogen, dextrins, glucose and lipoids, by mixing a paste of the water-soluble constituents of liver with aqueous alcohol of 60-80 per cent by volume and cooling the mixture to at least -15‹ F., preferably to 20‹F., and removing the insoluble substances which separate. The alcohol used is preferably of the strength of 70 per cent by volume. The alcoholic solution is evaporated in vacuo to. a thick syrup ; this is warmed and to each 100 grams &#39; are added about 800 cc. absolute alcohol; the mixture is allowed to settle, the alcohol decanted off and the residue dried under vacuum to a pasty consistency.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a novel extraction method wherein ginseng saponins are converted into saponins unique to red ginseng and extracted.  &lt;P&gt;SOLUTION: The method comprises a step of pressurizing and heating water or 1-6C alcohol to produce a high-pressure liquid solvent and a step of treating ginseng with the solvent to extract saponins. Alternatively, the method for converting the saponins in ginseng into the saponins unique to red ginseng and extracting the same comprises a step of extracting the saponins through acid treatment or treatment with a mixture of alcohol and acid. The method enables effective extraction of saponins and also enables extraction of ginsenosides Rg&lt;SB&gt;3&lt;/SB&gt;and Rh&lt;SB&gt;2&lt;/SB&gt;, compound K and PPD from ginseng lacking the saponins unique to red ginseng, e.g. ginsenosides Rg&lt;SB&gt;3&lt;/SB&gt;, Rh&lt;SB&gt;2&lt;/SB&gt;, etc., by producing the unique saponins through conversion. The extraction method is a batch-type method which enables easy extraction of saponins and can be used for more efficient, more economical production of an extract of the saponins unique to red ginseng.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide at least one double-stranded oligoribonucleotide (dsRNA) designed to inhibit the expression of a target gene.  &lt;P&gt;SOLUTION: One strand of the dsRNA is at least in part complementary to the target gene. The target gene can be selected from the following group: cancer cells, cytokine genes, Id protein genes, developmental genes, and prion genes. The target gene can express in pathogenic organisms (especially Plasmodium). The target gene can preferably also be a part of a virus or viroid which is pathogenic to human.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
The present invention discloses a dynamic plantar pressure sensing system. The dynamic plantar pressure sensing system includes a pressure sensing insole, a signal processing device and a cloud server. The pressure sensing insole is placed inside a shoe body and has a signal collector. The pressure sensing insole senses a plantar pressure signal of a user and transmits the sensed plantar pressure signal to the signal processing device through the signal collector. The signal processing device is used to receive pressure information transmitted by the signal collector and upload the pressure information to the cloud server. The cloud server analyzes the foot status of the user based on the plantar pressure signal, and then sends it back to the signal processing device for the user&#39;s reference.
PURPOSE:To obtain a coronary vasodilator applicable without causing the increase of pulse rate and blood pressure by using leaf of nicotineless tobacco and/or a water-soluble component of the combustion smoke tar of the leaf as active components. CONSTITUTION:The objective agent contains leaf of nicotineless tobacco having a nicotine-content of &lt;0.30wt.% and/or a water-soluble component of the combustion smoke tar of the leaf (hereinafter called simply as component A) as active components. The component may be used as a peroral drug by conventional process of as a parenteral injection using distilled water, physiological saline water, aqueous solution of glucose, etc. It is administered at a dose of 0.1-5mg of the component A per 1kg of body weight. The component A may be added to a combustible material to form a cigarette or to a food to be used as a chewing gum. It is useful for the remedy and prevention of heart stroke by increasing the coronary blood flow without accompanying side actions undesirable to coronary function, e.g. increase of blood pressure and pulse rate and the contraction of peripheral vessel.
Therapeutic index (TI) is a measure of drug safety based on the differential between minimal effective dose and maximal tolerable dose. Many small-molecule drugs show limited TI (below 10). Given patient variability, such a limited range can become further narrowed for a drug in practice, complicating its real-world use. Epigenetic drugs such as nuclear receptor ligands (NRLs)—which must reach the target cell&#39;s nucleus in order to function—pose a particular challenge because small-molecule drugs typically lack the evolved biological “intelligence” that natural molecules employ in order to reach their intracellular targets efficiently. Methods and compositions are disclosed herein for the treatment of peripheral immune tissues (PIT) using NRLs covalently attached to immodulin peptides. PIT includes surface draining lymph nodes of the upper and lower limbs and adjacent skin tissues. Dramatic improvements in the TI of NRLs can be gained from the immodulin scaffold&#39;s anatomic specificity (natural homing to PIT), precise organelle targeting (efficient cellular uptake and nuclear transport), and tunable mechanism of transcriptional action (immodulins themselves drive intranuclear RXR heterodimer formation naturally, thereby placing NRLs in close proximity to their RXR-heterodimer targets). The combined effect of such improvements is a 2-100-fold improvement in functional TI for small-molecule NRL drugs. This invention discloses three key components of that observed improvement: a preferential anatomical distribution of immodulins to the peripheral immune system when administered via a transdermal route, addition of hyaluronic acid to the diluent to enhance homing, and the novel use of transferrin for enhancing NRL-liganded immodulin recovery from a polymer-protected transdermal formulation.
Apparatus and associated methods relate to provide transient access rights to entities for creating, accessing, and/or sharing digital health content (DHC). In an illustrative example, a health content distribution system (HCDS) may generate a time-limited access token (TLAT) for authenticated users to access DHC. The TLAT, for example, may be generated based on a predetermined association of a corresponding DHC with a patient, a predetermined association of a requestor with the patient, a predetermined role of the requestor with relation to the patient, and a predetermined association between the requestor and a creator of the content. The TLAT may be further generated based on a predetermined association between the requestor and an organization associated with the patient. The HCDS may, for example, upon receiving the TLAT, transmit the corresponding DHC to be displayed at the requestor&#39;s device. Various embodiments may advantageously provide a secure on-demand health content access system.
The invention provides a method for producing a sterile and pyrogen-free column coupled to protein for use in removing a predetermined substance from the blood of a human subject. The method abrogates sterilization of the finished protein-containing product by providing sterile and pyrogen-free raw materials at each production step. The method provides a pathogen-free, purified solution of protein which binds to a predetermined substance in human blood such as LDL or immunoglobulin. Typically, the protein is anti-human LDL immunoglobulin or anti-human Ig immunoglobulin. The method also provides a sterile and pyrogen-free column matrix material such as an agarose which is chemically activated, either using CNBr and triethylamine or using 1,1&#39;-carbonyldiimidazole. The sterile and pyrogen-free, activated matrix material and the pathogen-free, purified protein solution are combined under aseptic conditions to effect the coupling of the protein to the matrix material, and the protein-coupled matrix material is filled under aseptic conditions into a sterile and pyrogen-free housing to produce a sterile and pyrogen-free column.
PROBLEM TO BE SOLVED: To evaluate the effect of a medicine which is effective to diabetes- related diseases and diseases caused by aging by measuring the pyridinium derivative or it salt contained in a tissue from a living body separated from human bodies, an extract of a tissue from a living body, body fluids, etc., and expressed by specific formulae. SOLUTION: The pyridinium derivative or its salt contained in a tissue from a living body separated from human bodies, an extract of a tissue from a living body, body fluid, urine, etc., and expressed by formulae I-IV is measured. In the formulae, R and R&#39; respectively represent an amino group, or an alkyl group which may have an amino group having a protecting group and/or a carboxyl group, and X represents a low alkyl group which may have hydrogen or a hydroxyl group. The alkyl groups represented by R and R&#39; include 1-6C alkyl groups, such as the methyl, ethyl, propyl. The protecting group of the amino group include acetyl, benzyl oxycarbonyl, p-chlorobenzyl oxycarbonyl, etc. In addition, the low alkyl group represented by X includes a 1-3C alkyl group, such as the methyl, ethyl, propyl, etc.
This invention relates to galanin and its uses. In particular, the invention provides a knockout mouse which lacks a functional galanin gene. The mouse may be used to investigate the effects of galanin. &lt;??&gt;It has also been unexpectedly discovered that galanin antagonists may be used in the management of pain, particularly painful neuropathies, the supression of pain, in the supression of location, in the treatment of prolactinoma and in anaesthesia. Additionally, the use of galanin agonists may be used in the treatment of Alzheimer&#39;s disease, in improving memory and cognition and in the treatment of nerve damage, such as the promotion of nerve regeneration.