anthonyyazdaniml/gliner-biomed-balanced-curated-corpus huggingface dataset:
FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to dentistry, and can be used for surgical management of chronic generalized periodontitis of severe degree. Method involves a preoperative local anti-inflammatory therapy, Cieszynski-Widmann-Neumann&#39;s flap surgery, wound washing after removal of granulation and de-epithelialization of flaps, replacement of bone defects with osteoplastic material and suturing in interdental spaces. Preoperative anti-inflammatory therapy is performed for 14 days. In the first two days, the alveolar process of both jaws is coated both from the vestibular and oral surfaces, wadding-gauze beads impregnated with a solution of a two-component probiotic containing Bacillus Subtilis 11B and Bacillus licheniformis 31 strains in amount of 1 to 5 billion cells, in 10 ml of normal saline with exposure of 30 minutes. On the following days, gauze turrets soaked with a two-component probiotic solution are introduced, which are introduced into periodontal pockets for 30 minutes. Wound is washed with a similar solution of a two-component probiotic. Bone defects between the dental roots are replaced with a wound healing plate containing, wt%: biomass of the B. subtilis 3H 30–50 strain, collagen 50–70, which is preliminarily cut in the form of a rectangular truncated pyramid corresponding to the size and shape of the bone defect, wherein when replacing the bone cavity, the small base of the pyramid should be at the level of the dental neck, and the large base adjoins the lower wall of the bone cavity. Layer of the wound-healing plate is applied above the alveolar part of the jaw so that it is adapted to the outlines of the alveolar crest and the neck of the teeth. Flaps are mobilized in the direction of the dental neck and sutures are applied.EFFECT: method provides stimulating reparative osteogenesis and preventing inflammatory postoperative complications.1 cl, 2 ex
PURPOSE:To obtain the titled cosmetic effective for lengthening and thickening the eyelashes and having improved characteristics such as feeling to the skin, etc., by adding a specific amount of a specific liquid polymer to an eyelash cosmetic containing a synthetic resin emulsion and/or wax and fibers. CONSTITUTION:The titled cosmetic is prepared by adding a polymer which is liquid at normal temperature and has an average molecular weight of &gt;=500, preferably &gt;=600, especially a liquid polybutene, to an eyelash cosmetic containing a synthetic resin emulsion and/or wax and fibers. The amount of the liquid  polymer is 0.5-20wt%, preferably 1-15wt%. The cosmetic thus obtains has excellent effect for lengthening and thickening the eyelashes and has various characteristics required as the eyelash cosmetic, e.g. applicability, state of finished eyelashes, removability, water-resistance, oil-resistance, useful life, etc.  The synthetic resin emulsion, wax and fiber may be known ones used in conventional eyelash cosmetics.
A pellet or bolus for administration to a ruminant by deposition in its rumeno-reticular sac where it is eroded away by rumen juices and releases active agent(s) and/or components, either continuously or in pulsed doses, comprises or incorporates a magnesium-based alloy which comprises at least 40% of magnesium, at least 30% zinc and up to 20% aluminium and, optionally, copper up to 5%, and trace elements, selected from cobalt, manganese, nickel and selenium up to 1%, the percentages being by weight. A paste can be made by heating the alloy to between its solidus and liquidus points, when it can be admixed with lead shot for weighting the bolus. The bolus may comprises a tubular sheath which contains alloy/iron shot filling. However, the alloy can be used for any appropriate component of a bolus, e.g. as illustrated. &lt;IMAGE&gt;
The invention provides apparatus for electrostatically coating a pharmaceutical tablet core with powdered coating material. The apparatus comprises a first rotary drum (12) on which a core is held in electrical isolation from its surroundings but at a potential difference to earth by an electrode which contacts the core. The core is carried past a coating station B at which particles of powder having an opposite potential difference to earth are held in a tray (18). The surface of the drum is held at the same potential difference to earth as the powder particles. The powder is attracted to the core, and not to the drum, coating the exposed surface of the core. The drum carries the coated core past a fusing station C at which a heater fuses the powder to form a continuous film coating. The core is then turned and transferred onto a second drum (12&#39;) where the other surface is coated in the same way.
The method for assessing the extent of pseudoaccommodation comprises the correction of the vision in the distance by the spherical lenses. The spherical reduction lens +0.5D is added to the correcting lenses. The projection of the anterior corneal surface to the zero mark of the horizontal ruler is estimated using the plumb line. The device is moved from the end of the ruler to 20-cm mark. Each 10 cm, Landolt rings are shown to the patient. The size of the rings is reduced until the patient is no more able to discern the direction of ring&#39;s break. Taking into account the size of the index and the distance to the eye recorded for this index size the minimal effective vision angle is calculated in the seconds of arc.
A computerized method for correlating features of a user&#39;s motion in a VR-based exercise with specified populations includes the step of tracking a user&#39;s motion in a VR-based exercise with a hand controller. Based on a set of datapoints obtained from a sequence of positions of the hand controller, the method extracts a dynamic range of the user&#39;s motion. Based on the dynamic range, the method determines a velocity, an acceleration of the user&#39;s motion. The method determines the coefficient of variation for the velocity and the acceleration. From the acceleration and velocity data, the method calculates an initiation of the user&#39;s motion. The method calculates a combinatorial statistic from the coefficient of variation for the velocity ad the acceleration. The method determines a set of features of the user&#39;s motion represented by the combinatorial statistic that correlates to another combinatorial statistic associated with a specified population.
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a method for preserving microorganisms and materials originating from an animal.  &lt;P&gt;SOLUTION: This method for preserving the microorganisms or the materials originating from the animal is provided by placing them under an electrostatic field atmosphere for preservation. The electrostatic field atmosphere is formed by impressing 100-5,000 V alternate or direct electric voltage on electrodes. The preserving temperature under the electrostatic field atmosphere is -20 to 40°C, and it is possible to preserve the microorganisms or materials originated from the animal including human without freezing at -12 to -1°C at which temperature such organisms or materials can be frozen unless under the electrostatic field atmosphere. The method for preservation is useful for the preservation of organs, internal organs, tissues, cells, blood, plasma, serum, a blood preparation, a purified protein, a recombinant protein, cultured cells, cultured tissues, etc., and can be utilized especially in a transplanting field, blood transfusion field, regenerative medicinal field, basic experimental field, genetic therapeutic field, clinical test field, pharmaceutical field, diagnostic field, etc.  &lt;P&gt;COPYRIGHT: (C)2005,JPO&amp;NCIPI
The invention refers to a fungicidal composition comprising two or three active components in which as an active element I is used metalaxyl containing more than 70 mass. % of R-enantiomer. In quality of the component II may be used: mancozeb (IIA), chlorothalonil (IIB), copper inorganic compounds (IIC), folpet (IID), fluazinam (IIE), zimoxanyl (IIF), utilized independently or as a third component of mixture with one of above mentioned component. In addition, it is claimed a process for control and prevention of plants Oomycetes infection. The technical result consists in improvement of the obtained composition fungicidal activity. Claims: 20 &lt;IMAGE&gt;
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a new mineral-filled soap mild to a skin and feeding nutrition to the skin.  &lt;P&gt;SOLUTION: This mineral-filled soap comprises a soap substrate, a humic shale (humus shale) extract, a herbal medicine extract and ceramide. The herbal medicine extract is preferably a mixture of liquids containing the herbal medicine component extracted by dipping glycyrrhiza, a sophora root and a coix seed in an alcohol or butylene glycol for 2-3 weeks. The mineral-filled soap can be made by mixing a desired amount of the humic shale extract, the herbal medicine extract and ceramide with the heated, liquified soap substrate, casting the resulting mixture, standing it to cool and solidify, and decasting it. The mineral-filled soap can also be made by mixing a required amount of the humic shale extract with an emulsified reaction product that is produced by saponification of a heated vegetable oil with an aqueous caustic soda solution under enough agitation, casting the mixture into a mold, standing it to cool and solidify, and demolding it.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
&lt;P&gt;PROBLEM TO BE SOLVED: To provide a slimming-assisting fragrance designed to enjoy fragrance and also suppress appetite and assist user&#39;s slimming by inhaling the fragrance.  &lt;P&gt;SOLUTION: The slimming-assisting fragrance is such that at least one of fennel essential oil and patchouli oil is served as an appetite-suppressive fragrant component and an appetite-suppressive fragrant component carrier consisting of at least one of charcoal powder and adsorbent adsorptively bearing the above component is included in a fragrant composition. In this fragrance, the fragrant composition comprises 5-60 wt.% of a woody base as solid component, ≤60 wt.% of inorganic base powder and 1-80 wt.% of the above carrier, wherein the carrier contains at least one of ≤80 wt.% charcoal powder and ≤50 wt.% adsorbent and at least one of fennel essential oil and patchouli oil is contained at 1-30 wt.% based on 100 pts.wt. of the above solid component, and as part of the solid component, at least one of fennel powder and Pogostemon cablin Benth. powder may be included at 1-40 wt.%.  &lt;P&gt;COPYRIGHT: (C)2007,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To obtain a cosmetic excellent in moisture-retaining effect and free from stickiness by compounding a polyhydric alcohol having two or more hydroxyl groups in the molecule with a specific amount of a specific amide compound. SOLUTION: This cosmetic is obtained by compounding 0.5-50wt.% polyhydric alcohol having two or more kinds of hydroxyl groups in the molecule and then, compounding one or two or more kinds of amine compounds of the formula (R is an alkyl or an alkenyl; A is an alkylene; B is n alkylene; Y is carboxyl, sulfone, sulfate, etc.) in a weight ratio of 0.01-4 based on the polyhydric alcohol therewith. The polyhydric alcohol includes e.g. dipropylene glycol, 1,3-butylene glycol or glycerol. The amide compound of the formula includes e.g. N,N&#39;-bis(2- myristoylamideethyl)ethylenediamine-N,N&#39;-di(sodium acetate).
FIELD: medicine. ^ SUBSTANCE: invention relates to chemical-pharmacological industry, namely to creation of medication for treatment of chronic kidney disease in predialystic and dialytic periods. Medication contains soy-bean isolate of &#34;Supro&#34; type, water-soluble fat, carbohydrate, emulsifier, food fibres, succinic and glutaminnic acids. Intake of given medication is carried out in predialytic period - in amount 1.3 g of medication per 1 kg of body weight per day, and in dialytic period - 1.7 g of medication per 1 kg of body weight per day, preliminarily dissolving it in water. ^ EFFECT: method and medication reduce infection complications and increase live quality. ^ 2 cl, 3 ex
Methods and compositions for treating urogenital tumors, and in particular, cancer of the prostate, bladder, and kidney, with BCNT, are disclosed. Any boron-containing compound that is sufficiently lipophilic to pass through the appropriate urogenital membranes in a quantity high enough to achieve therapy on irradiation with low-energy neutrons can be used. Carboranyl-containing nucleosides and oligonucleotides are particularly suited for use in BNCT of urogenital tumors.  Preferred compounds include 5-carboranyl-2&#39;-deoxyuridine (CDU) and 5-o-carboranyl-l-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)uracil (CFAU). Nucleosides and oligonucleotides bearing an -O-[(carboran-1-yl)alkyl]phosphate, S-[(carboran-1-yl)alkyl]phosphorothioate, or Se-[(carboran-1-yl)alkyl]phosphoroselenoate in place of the (carboran-1-yl)phosphonate moiety can be used. Oligonucleotides of specific gene sequences that include one or more 3&#39;, 5&#39;-linking-(carboran-1-yl)phosphonate moieties can also be used in antisense therapy in the selective modification of gene expression. Compounds can be used in urogenital BNCT therapy that contain boron clusters as a means to enhance lipophilicity wherein the boron is not enriched in 10B, but instead, in the 11B isotope. The therapy is accomplished by administering the boron-containing compound by any appropriate route, including by intravenous injection, oral delivery or by catheter or other direct means, in such a manner that the compound accumulates in the target tumor. After desired accumulation of the compound in the tumor, the site is irradiated with an effective amount of low energy neutrons.
&lt;P&gt;PROBLEM TO BE SOLVED: To obtain a dosage form comfortable with respect to its feeling of use, especially in feeling after use.  &lt;P&gt;SOLUTION: The skin care preparation comprises (1) an extract of fruit of Eugenia aromatica of the family Myrtaceae and (2) a polyether-modified methylpolysiloxane. The extract of fruit of Eugenia aromatica of the family Myrtaceae is prescribed to have eugenol as an index substance. Preferably the eugenol content is 1-10 mass% based on the total of the extract. Preferably the extract of fruit of the Eugenia aromatica of the family Myrtaceae is obtained by extracting a fruit of the Eugenia aromatica of the family Myrtaceae with an alcohol. Preferably the skin care preparation contains a polymer having a biocompatible group.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
PROBLEM TO BE SOLVED: To obtain the subject composition having high improving effects on skin roughening or dryness even in the case of dry skin or sensitive skin and high prophylactic and improving effects on atopic dermatitis, etc., and further capable of improving skin quality easily causing skin trouble by including one or more kinds selected from cedrol, cedrenol, farnesol, etc. SOLUTION: This composition is obtained by including one or more ingredients selected from cedrol, cedrenol, farnesol, patchouli alcohol, vetiverol and α-damascone. The amount of the formulated ingredients in the composition is preferably &gt;=10 ppm. Furthermore, an extract from a plant containing the ingredients (e.g. a cedar, a patchouli or a vetiver) or a steam distillied substance or a pressed material can be used in the composition. A horny layer-containing lipid or its analog (e.g. a natural ceramide, a ceramide analog, a phospholipid or a fatty acid ester of steroids) in addition to the ingredients may be contained in the composition.
Methods are disclosed herein for increasing the number of stem cells or precursor cells. The number of stem cells can be increased by increasing survival and/or cell proliferation of the cells. The methods include contacting the cells with an effective amount of a Notch ligand, an effective amount of a growth factor, and an effective amount of angiopoietin-2 (Ang-2). In several embodiments, the methods include contacting the cells with an effective amount of a Jak inhibitor. In several non-limiting examples, the growth factor is insulin or glial derived neurotrophic factor (GDNF), or a combination thereof. In additional non-limiting examples, the Notch ligand is Delta. The cells can be in vivo orin vitro. Methods are also disclosed here for the treatment of a neurodegenerative disorder or spinal cord injury in a subject. In several non-limiting examples, the subject has Parkinson&#39;s disease or Alzheimer&#39;s disease.
&lt;P&gt;PROBLEM TO BE SOLVED: To economically produce arachidonic acid and to provide a food formulated with the same.  &lt;P&gt;SOLUTION: Mortierella sect. schmuckeri microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. The arachidonic acid is important as a precursor of eicosanoid which is a nutrient for infant, and a food product which includes Mortierella sect. schmuckeri microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product for infant is produced.  &lt;P&gt;COPYRIGHT: (C)2008,JPO&amp;INPIT
PURPOSE:To obtain an injection agent by dissolving a pheophorbide derivative together with an aliphatic polycarboxylic acid in water. CONSTITUTION:This injection agent is obtained by dissolving a compound of the formula [Z is O or NH; (n) is 1-6; Y is NR&#39; or R&#39;&#39; (R&#39; and R&#39;&#39; each is a 1-4C alkyl); R1 is ethenyl, a 1-4C alkyl, etc.; R2 is CH3, CHO, etc.; R3 and R4. are such that one party is H and the other OH, or are combined into =O; R5 is H or COOCH3] and an aliphatic polycarboxylic acid at the molar ratio of 1 to (1.25-6) in water. For the polycarboxylic acid, aromatic ring-contg. ones and amino acids are excepted because of their poor ability to dissolve the compound of the formula in water, tartaric acid or maleic acid is preferable. The resultant aqueous solution is filtered and sterilized to obtain the objective injection agent. By evaporating this agent to dryness, a dried medicinal composition redissolvable easily and assuredly can be obtained. By the method of the present invention, the pheophorbide derivative can be dissolved in water without the need for any dissolving auxiliary or surfactant. The compound of the formula is useful as a photosensitizer in the photodynamic therapy for cancer.
PURPOSE:To obtain a cleaning agent compsn. with excellent foaming power and foam quality, reduced irritativeness to skins and hairs and furthermore improved cleaning properties by compounding a nonionic surfactant with a specified polyethyleneimine polymer. CONSTITUTION:A copolymer (A) with repeating units of formulas I and II (wherein R&lt;1&gt; is H, CH3 or C2H5; R&lt;2&gt; is a 4-15C alkyl, aryl or aralkyl) in a wt. ratio of formula I to formula II of 9/1 to 1/9 (polyethyleneimine polymer) and a nonionic surfactant (B) (e.g. polyoxyethylene alkyl ether) are compounded. Even though the nonionic surfactant has a feature of weak irritativeness to skins, there arises sometimes a problem on its inferior foaming power and foam quality to those of other surfactant. It is possible by the abovedescribed combination to obtain a cleaning agent compsn. with excellent foaming power and foam quality, reduced irritativeness to skins and hairs, and furthermore improve cleaning properties.
FIELD: apiculture. SUBSTANCE: invention relates to agent used in treatment of bees against varrhoatosis. Invention proposes the preparation comprising a mixture of amitraze species in compound 2,4- and 2,6-dimethylphenyl as an active substance and surface-active substance synthanol DS-10. The preparation is used as bands with applied acaricide by method of pouring into well. The application of preparation enhances effectiveness of &#34;Dilabik B&#34; and reduces immunity of mite to this preparation. EFFECT: enhanced effectiveness of treatment. 5 ex
PURPOSE:To obtain the titled cosmetic having excellent emulsified state in acidic region, high age stability and high safety to skin, by compounding an N&lt;alpha&gt;,N&lt;alpha&gt;-dimethyl-N&lt;epsilon&gt;-long-chain acyllysine as an emulsifier. CONSTITUTION:The titled cosmetic contains 0.01-10.0wt% compound of formula (R is 16-22C acyl). The compound of formula may be used singly or in combination or other surfactant may be used as an emulsifying assistant. The above cosmetic may be compounded properly with conventional humectant, ultraviolet absorber, alcohol, preservative, thickener, pigment, perfume, etc. Any oil-phase component used in conventional cosmetics may be used in the present cosmetic. The compound of formula may be added to the oil phase or the aqueous phase in the production of the above cosmetic.
PURPOSE:To prepare a cosmetic having remarkably improved effect for the prevention of the skin darkening, spots, freckles, etc. caused by the inhibition of tyrosinase activity, by compounding an S,S-diacyl lipoic acid to a cosmetic base. CONSTITUTION:An S,S-diacyl lipoic acid of formula (R is straight- or branched- chain fatty acid acyl residue; R&#39; is H or straight- or branched-chain alcohol alkyl residue) or its alkyl ester derivative, e.g. S,S-dibutanoyl lipoic acid, is compounded in a cosmetic composition in an amount of 0.01-5wt%, pref. 0.1- 1wt% of the cosmetic composition as a whole. The S,S-diacyl lipoic acid can be obtained by cleaving the disulfide bond of alpha-lipoic acid with a reducing agent in a solvent, and reacting the resultant dihydrolipoic acid with a desired fatty acid chloride in a non-polar solvent in the presence of a base.
Oil-in-water (O/W) and water-in-oil (W/O) microemulsions of fragrance product formulations are provided. The microemulsions are clear or at least translucent, sprayable, and non-sticky. Novel combinations of anionic surfactant components (a) and hydrophilic coactives (highly water soluble component (b) or a mixture of highly water soluble (b)(i) and less water soluble polar (b)(ii) components) are used to obtain fragrance product formulations that are free or substantially free of ethanol. The anionic surfactants have a hydrophilic-lipophilic balance (&#34;HLB&#34;) modified by the use of classes of anionic surfactant components (a) and commercially available hydrophilic component coactives ((b) or mixture of (b)(i) and (b)(ii)), not previously recognized as effective in this type of system. Highly, preferably infinitely, water soluble coactives (b) as well as mixtures of highly, preferably infinitely, water soluble coactives (b)(i) with other less water soluble polar coactives (b)(ii), modify the HLB of anionic surfactants in such a way as to enable the formation of stable, clear microemulsions of fragrance product compositions. These compositions contain lower ratios of surfactant to oil than conventional nonionic (or ionic surfactants with lipophilic coactives) aqueous or alcohol free compositions. As such, the present fragrance compositions are sprayable and nonsticky.
PURPOSE:To provide a new branched chain-type derivative capable of imparting fine particle carriers with high organotropism. CONSTITUTION:The derivative of formula I {n is 4 or 3; when n is 4, S&lt;4&gt; being of formula II or III (wavy bond is alpha or beta bond), etc.; when n is 3, S&lt;3&gt; being of formula IV, etc. [Y is (CH2)rN3, COR1 (r is 2-10; R1 is OH, NHNH2, etc.), etc.]; X is H, benzyl, carboxymethyl, of formula V, formula VI [T is of formula VII (R is H or acetyl), etc.; m is 2-8], etc.}, e.g. a compound of formula NIII. The compound of the formula I can be obtained, for example, by the following process: a bromoalkanol is made to react with an OH-protected saccharide in the presence of a Lewis acid such as boron trifluoride ether followed by reaction with sodium azide to introduce an azide chain into the 1-site of the saccharide to represent skeleton to form an azide derivative, which is, in turn, reduced by hydrogen in the presence of Lindlar catalyst into an amine modification, which is then made to react with a carbonyl compound in the presence of dicyclohexylcarbodiimide followed by deacetylation.