Intervention: Tetracycline
Trial phase: Phase 2
ATC code: A01AB13 | A02BD02 | A02BD08 | D06AA04 | J01AA07 | J01AA20 | J01RA08 | S01AA09 | S02AA08 | S03AA02
SMILES: [H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c1c(O)cccc1[C@@]2(C)O
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: No
Participants at risk: 107
Group description: Patients will receive tetracycline 250mg every 12 hours for 1 month plus general dermatological recommendations (sunscreen and emollient cream)

Tetracycline: The experimental group will receive tetracycline 250mg every 12 hours for 1 month the same day at initiation of BIBW 2992
Eligibility criteria:
Inclusion Criteria:

Diagnosis of non-operable, locally advanced, recurrent or metastatic, histologically or cytologically documented non-small cell lung cancer (stage IIIB or IV).

Patients should have an evidence of measurable disease.
18 years or older
Eastern Cooperative Oncology Group - Performance Status 0-3
At least 12 weeks of life expectancy
Patients with non-small cell lung cancer stages IIIB/IV who have received at least one cycle of platinum-based, first or second line systemic standard chemotherapy, and have a documented failure for this treatment.
More than 2 previous chemotherapy regimens are not allowed. The patients should have recovered from any toxic effect and at least 2 weeks should have elapsed from last dose before their entry (14 days for vinorelbine and other vinca alkaloids or gemcitabine). Patients who in the investigator's opinion are fully recovered from surgery for at least 4 weeks may also be considered for the study. Patients should have recovered from any severe toxicity (CTC > 1) caused by any previous therapy.
Granulocyte count > 1.5x 109/L and platelet count > 100x 109/L.
Serum bilirubin > 1.5 upper limit of normal (ULN)
AST and/or ALT > 2 ULN (or >5 x ULN when clearly attributable to presence of hepatic metastases).
Serum creatinine > 1.5 ULN or creatinine clearance < 60 mL/min
Capability to fulfill the study and follow-up procedures.
A negative pregnancy test should be obtained from all women of childbearing potential within 72 hours previous to therapy beginning.
Patients of reproductive potential should use effective contraceptive methods.
Written (signed) informed consent to participate in the study

Exclusion Criteria:

Patients allergic to the antibiotic therapy used.
Any unsteady systemic disease (including active infection, uncontrolled hypertension, unsteady angina, congestive cardiac failure, hepatic, renal or metabolic disease).
A previous treatment using a systemic anti-tumor therapy with EGFR inhibitors (tyrosine kinase inhibitors).
Any other malignant pathology within 5 previous years (except for carcinoma in situ of cervix or basal-cell type skin cancer appropriately treated).
Patients with cerebral metastases or spinal marrow compression recently diagnosed and/or definitely surgery and/or radiation naïve-treatment patients are excluded. Those with previously diagnosed and treated metastasis to Central Nervous System (CNS) or spinal marrow compression, having an evidence of steady disease (clinically steady in imaging studies) are accepted for at least 2 months.
Any significant ophthalmologic abnormality, especially severe dry-eye syndrome, keratoconjunctivitis sicca, Sjögren's syndrome, severe exposure keratitis and any other disorder that may increase the risk for corneal epithelial injure. Contact lens use during the study is not recommended. The decision to continue to use contact lens should be discussed with the oncologist responsible for patient treatment and the ophthalmologist.
Patients who cannot take oral medication, requiring intravenous nutrition, who underwent previous surgical procedures affecting absorption, or with active peptic ulcer.
Nursing women.