Intervention: Enstilar
Trial phase: Phase 4
SMILES: C=C1C(=CC=C2CCCC3(C)C2CCC3C(C)C=CC(O)C2CC2)CC(O)CC1O.CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(F)C(O)CC21C
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: Accepts Healthy Volunteers
Participants at risk: 20
Group description: Subjects will receive calcipotriene hydrate/betamethasone dipropionate (Enstilar) foam and apply to affected areas once daily. A target lesion located on elbow or knee will be identified by the Investigator for daily treatment with the medicated foam from Baseline through week 4.

Enstilar: Enstilar foam applied to affected area once daily
Eligibility criteria:
Inclusion Criteria:

Outpatient, male or female subjects of any race, 18 years of age or higher. Female subjects of childbearing potential must have a (-) urine pregnancy test (UPT) result within 7 days of the first dose of study drug and practice a reliable method of contraception throughout the study.

A female is considered of childbearing potential unless she is:

- postmenopausal >5 years, without a uterus and/or both ovaries, or has been surgically sterile for >6 months

Reliable methods of contraception are:

- hormonal methods or intrauterine device (IUD) in use > 90 days prior to study drug administration, barrier methods plus spermicide in use > 14 days prior, or vasectomized partner.

[Exception: Female subjects of child bearing potential (CBP) who are not sexually active are not required to practice a reliable method of contraception and may be enrolled at the Investigator's discretion provided they are counselled to remain sexually inactive for the duration of the study and understand the risks involved in getting pregnant during the study.]

Moderate plaque type psoriasis eligible for topical therapies.
Patients with a minimum of 3% BSA to a maximum of 20% BSA & bilateral symmetric psoriatic plaques of 2 to 4 cm in diameter.
Physician Global Assessment (PGA) score of 3.

Able to understand study requirements and sign Informed Consent/HIPAA forms.

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Exclusion Criteria:

Female subjects who are pregnant, breast-feeding, or who are of childbearing potential and not practicing a reliable method of birth control, or male subjects planning a pregnancy with their spouse or partner while in the study.
History of hypercalcaemia or vitamin D toxicity.
Patients with guttate, erythrodermic, or pustular psoriasis
Serious skin condition (other than psoriasis) or uncontrolled medical condition (in the opinion of the investigator.)
Topical steroids, topical immunomodulators, topical vitamin D derivatives, tar, salicylic acid, anthralin or any other topical treatment for psoriasis within 2 weeks of baseline.
Use of any biologics within 3 months of baseline.
Use of other systemic psoriasis treatments (ie, oral retinoids, methotrexate, cyclosporine, or other immunomodulators) within 4 weeks of baseline.
Use of ultraviolet B rays (UVB) or psoralen+ultraviolet a rays (PUVA) within 2 weeks of baseline.
Skin conditions (e.g. eczema) other than psoriasis that may interfere with evaluations of psoriasis.
Known hypersensitivity to Enstilar or any of its components.
Contraindications according to Enstilar.
Current drug or alcohol abuse (Investigator opinion.)
Subject unable to commit to all the assessments required by protocol. -