Intervention: Pomaglumetad methionil
Trial phase: Phase 3
SMILES: CSCCC(N)C(=O)NC1(C(=O)O)CS(=O)(=O)C2C(C(=O)O)C21
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: No
Participants at risk: 110
Group description: 80 mg/day LY2140023: A 40-mg LY2140023 tablet, administered orally, BID for 6 weeks, post-randomization.
Eligibility criteria:
Inclusion Criteria:

Diagnosis of schizophrenia as defined in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR); and confirmed by the Structured Clinical Interview for DSM-IV-TR (SCID)
Non pregnant female patients who agree to use acceptable birth control
Participants must be considered moderately ill in the opinion of the investigator
Patients in whom a modification of antipsychotic medication or initiation of antipsychotic medication is acutely indicated in the opinion of the investigator
Willing to participate in a minimum of 2 weeks of inpatient hospitalization
One year history of Schizophrenia prior to entering the study
At study entry patients with a history of antipsychotic treatment must have a lifetime history of at least one hospitalization for the treatment of schizophrenia, not including the hospitalization required for study. Patients who have never taken antipsychotic treatment may enter the study even without a history of hospitalization.
At study entry patients with a history of antipsychotic treatment must have a history of at least one episode of illness exacerbation requiring an intensification of treatment intervention or care in the last 2 years, not including the present episode of illness. Patients who have never taken antipsychotic treatment may enter the study without a past history of illness exacerbation and intensification of treatment in the last 2 years.
At study entry patients must have experienced an exacerbation of illness within the 2 weeks prior to entering the study, leading to an intensification of psychiatric care in the opinion of the investigator. If exacerbation occurs in patients who are presently hospitalized, the patient must not have been hospitalized longer than 60 days at entry of the study.
Patients must be considered reliable and have a level of understanding sufficient to perform all tests and examinations required by the protocol, and be willing to perform all study procedures

Exclusion Criteria:

Patients who have a history of inadequate clinical response to antipsychotic treatment for schizophrenia
Diagnosis of substance dependence or substance abuse within 6 month of study entry
Diagnosis of substance-induced psychosis within 7 days of study entry
Currently enrolled in, or discontinued within 6 months from a clinical trial involving an investigational product or unapproved use of a drug or device
Participated in any clinical trial with any pharmacological treatment intervention for which they received a study-related medication in the 6 months prior to study entry
Previously completed or withdrawn from this study, or any other study investigating LY2140023 or any predecessor molecules with glutamatergic activity
Treatment with clozapine at doses greater than 200 mg daily within 12 months prior to entering the study, or who have received any clozapine at all during the month before study entry
Patients currently receiving treatment (within 1 dosing interval, minimum of 4 weeks, prior entering the study) with a depot formulation of an antipsychotic medication
Patients who are currently suicidal
Females who are pregnant, nursing, or who intend to become pregnant within 30 days of completing the study
Patients with uncorrected narrow-angle glaucoma, uncontrolled diabetes, certain diseases of the liver, renal insufficiency, uncontrolled thyroid condition or other serious or unstable illnesses
Have a history of one or more seizures
Electroconvulsive therapy (ECT) within 3 months of entering the study or who will have ECT at any time during the study
History of low white blood cell count
Medical history of Human Immunodeficiency Virus positive (HIV+) status.
Higher than normal blood prolactin levels
Abnormal electrocardiogram results