Intervention: Simvastatin
Trial phase: Phase 1
ATC code: A10BH51 | C10AA01 | C10BA02 | C10BA04 | C10BX01 | C10BX04
SMILES: CCC(C)(C)C(=O)OC1CC(C)C=C2C=CC(C)C(CCC3CC(O)CC(=O)O3)C21
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: Accepts Healthy Volunteers
Participants at risk: 62
Group description: Part 2, Cohorts B, Period 1, Participants will receive simvastatin 40 mg orally, once daily on Days 1 - 4.
Eligibility criteria:
Inclusion Criteria:

Are native Chinese and living in China.
Are overtly healthy males or females as determined by medical history and physical examination.

Female participants:

Women not of child-bearing potential
Women of child-bearing potential must correctly use 2 forms of reliable contraception to avoid getting pregnant during the study and for 3 months after the study is completed.
Body Mass Index: 19.0 to 24.0 kilogram per square meter (kg/m^2)
BP and pulse rate at both supine and standing positions of approximately a systolic BP ≤ 140 millimeter of mercury (mm Hg), and diastolic BP ≤ 90 mm Hg
Participants with untreated hypercholesterolemia may be included if not on an herbal or other traditional Chinese medicines (TCM)
Have no known liver disease
Have given written informed consent

Exclusion Criteria:

Are currently enrolled in a clinical trial involving an investigational product (IP) or off-label use of a drug or device, or are concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study.
Have known allergies to evacetrapib, simvastatin, or atorvastatin, related compounds or any components of the formulation
Have previously completed or withdrawn from this study or any other study investigating evacetrapib, and have previously received the IP within 3 months.
Have a history within the last year or presence of cardiovascular, respiratory, hepatic, renal, gastrointestinal, endocrine, hematologic, or neurologic disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the study medication; or of interfering with the interpretation of data.
Show evidence of significant active neuropsychiatric disease.
Regularly use known drugs of abuse
Are women with a positive pregnancy test or women who are lactating.

Have used or intend to use over-the-counter or prescription medications (including vitamins/mineral supplements) or TCM 14 days prior to the first dose and during the study.

Hormonal contraceptives are permitted.
Use of any drugs or substances that are known to be substrates, inducers, or inhibitors of organic anion transporting polypeptide 1B1 (OATP1B1), or of any other transporters involved in simvastatin or atorvastatin disposition, or of any drugs or substances that are known to be strong inducers or inhibitors of cytochrome P450 3A (CYP3A) within 30 days prior to the first dose and throughout the study.
Donated blood of >400 mL within the last month.
Drink alcoholic beverages with intake that exceeds 28 units per week (males) and 21 units per week (females), or are unwilling to stop alcohol consumption 48 hours prior to dosing until discharge from the clinical research unit (CRU) (1 unit = 12 oz or 360 mL of beer; 5 oz or 150 mL of wine; 1.5 oz or 45 mL of distilled spirits).
Are unwilling to comply with the dietary requirements/restrictions during the study