Intervention: Verubecestat
Trial phase: Phase 1
SMILES: CN1C(N)=N[C@](C)(c2cc(NC(=O)c3ccc(F)cn3)ccc2F)CS1(=O)=O
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: Accepts Healthy Volunteers
Participants at risk: 8
Group description: Single oral dose of MK-8931 (40 mg tablet) in healthy matched participants in fasted state (Part I)
Eligibility criteria:
Inclusion Criteria: Participants with HI

Adult male or female participants, 45-85 years of age, inclusive, at screening.
Body Mass Index (BMI) ≥ 19 and ≤ 40 kg/m^2, at screening.
Continuous non-smokers or light smokers (< 10 cigarettes/day or the equivalent).
Baseline health is judged to be stable based on medical history (except for the hepatic insufficiency condition).
Participant has a diagnosis of chronic (> 6 months), stable (no acute episodes of illness within the previous 2 months due to deterioration in hepatic function) HI with features of cirrhosis due to any etiology.
Part 1 only: Participant's score on the Child-Pugh scale must range from 7 to 9 (moderate HI) at screening.
Part 2 only: Participant's score on the Child-Pugh scale must range from 5 to 6 (mild HI) at screening.
Participants must be completely informed of the unknown risks of pregnancy and agree not to become pregnant or father a child during the time they are participating in this study.
For a female of childbearing potential: either be sexually inactive (abstinent) for 14 days prior to dosing and throughout the study or be using an acceptable birth control method.

Females of non-childbearing potential must have undergone one of the following sterilization procedures at least 6 months prior to the first dose:

hysteroscopic sterilization;
bilateral tubal ligation or bilateral salpingectomy;
hysterectomy;
bilateral oophorectomy; or be postmenopausal with amenorrhea for at least 1 year prior to dosing and have follicle-stimulating hormone (FSH) serum levels consistent with postmenopausal status as per Investigator or designee's judgment.
Non-vasectomized male participants must agree to use a condom with spermicide or abstain from sexual intercourse from dosing until 90 days after dosing.
Male participants must agree not to donate sperm from dosing until 90 days after dosing.
Understands the study procedures in informed consent forms (ICFs), be willing and able to comply with the protocol, and provides written informed consent for the trial, including for Future Biomedical Research. Future Biomedical Research participation is voluntary and is not required in order to participate in the trial.

Inclusion Criteria: Healthy Control Participants

Healthy adult male or female participants, 45-85 years of age, inclusive, at screening.
BMI ≥ 19 and ≤ 40 kg/m^2 at screening.
Continuous non-smokers or light smokers (< 10 cigarettes/day or the equivalent).
Medically healthy with no clinically significant medical history, physical examination, laboratory profiles, vital signs, or electrocardiograms (ECGs), as deemed by the Investigator.
Participants must be completely informed of the unknown risks of pregnancy and agree not to become pregnant or father a child during the time they are participating in this study.
For a female of childbearing potential: either be sexually inactive (abstinent) for 14 days prior to dosing and throughout the study or be using an acceptable birth control method.

Females of non-childbearing potential must have undergone one of the following sterilization procedures at least 6 months prior to the first dose:

hysteroscopic sterilization;
bilateral tubal ligation or bilateral salpingectomy;
hysterectomy;
bilateral oophorectomy; or be postmenopausal with amenorrhea for at least 1 year prior to dosing and have FSH serum levels consistent with postmenopausal status as per Investigator or designee's judgment.
Non-vasectomized male participants must agree to use a condom with spermicide or abstain from sexual intercourse from dosing until 90 days after dosing.
Male participants must agree not to donate sperm from dosing until 90 days after dosing.
Understands the study procedures in ICFs, be willing and able to comply with the protocol, and provides written informed consent for the trial, including for Future Biomedical Research. Future Biomedical Research participation is voluntary and is not required in order to participate in the trial.

Exclusion Criteria: Participants with HI

Participant is mentally or legally incapacitated or has significant emotional problems at the time of the screening visit or expected during the conduct of the study.
History or presence of clinically significant medical or psychiatric condition or disease in the opinion of the Investigator.
History of any illness that, in the opinion of the Investigator, might confound the results of the study or poses an additional risk to the participant by their participation in the study.
History or presence of alcoholism or drug abuse within the past 2 years prior to dosing.
History or presence of hypersensitivity or idiosyncratic reaction to the study drug or related compounds.
Female participants who are pregnant or lactating.
Positive results for the urine drug and/or alcohol screen at screening or check-in, unless the positive drug screen is due to prescription drug use and is approved by the Investigator and the Sponsor Medical Monitor.
Positive results at screening for human immunodeficiency virus (HIV) or hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV; i.e., HCV antibody positive, HCV ribonucleic acid (RNA) positive) with decompensated liver disease.
Seated blood pressure is less than 90/40 mmHg or greater than 180/105 mmHg at screening.
Seated heart rate is lower than 40 bpm or higher than 99 bpm at screening.
Fridericia's correction of the QT interval (QTcF) is > 480 msec or has ECG findings deemed abnormal with clinical significance by the Investigator or designee at screening.
Abnormal hemoglobin level deemed clinically significant by the Investigator at screening.
Unable to refrain from or anticipates the use of any medication or substance (including prescription or over-the-counter, vitamin supplements, natural or herbal supplements).
Has been on a diet incompatible with the Clinical Research Unit (CRU) -provided standard meals/snacks, in the opinion of the Investigator, within the 28 days prior to dosing of study drug, and throughout the study.
Donation of blood or had significant blood loss within 56 days prior to dosing of study drug.
Plasma donation within 28 days prior to dosing of study drug.
Is or has an immediate family member (e.g., spouse, parent/legal guardian, sibling or child) who is investigational site or Sponsor staff directly involved with this study.
Participation in another clinical trial within 28 days prior to dosing.
Participant who dosed in one part (e.g., Part 1) will not be enrolled in the other part (e.g., Part 2).

Exclusion Criteria: Healthy Control Participants

Participant is mentally or legally incapacitated or has significant emotional problems at the time of the screening visit or expected during the conduct of the study.
History or presence of clinically significant medical or psychiatric condition or disease in the opinion of the Investigator.
History of any illness that, in the opinion of the Investigator, might confound the results of the study or poses an additional risk to the participant by their participation in the study.
History or presence of alcoholism or drug abuse within the past 2 years prior to dosing.
History or presence of hypersensitivity or idiosyncratic reaction to the study drug or related compounds.
Female participants who are pregnant or lactating.
Positive results for the urine drug and/or urine or breath alcohol screen at screening or check-in.
Positive results at screening for HIV or HBsAg or HCV with decompensated liver disease.
Seated blood pressure is less than 90/40 mmHg or greater than 140/90 mmHg at screening.
Seated heart rate is lower than 40 bpm or higher than 99 bpm at screening.
QTcF is > 480 msec or has ECG findings deemed abnormal with clinical significance by the Investigator or designee at screening.
Abnormal hemoglobin level deemed clinically significant by the Investigator at screening.
Unable to refrain from or anticipates the use of any medication or substance (including prescription or over-the-counter, vitamin supplements, natural or herbal supplements).
Has been on a diet incompatible with the CRU-provided standard meals/snacks, in the opinion of the Investigator, within the 28 days prior to dosing of study drug, and throughout the study.
Donation of blood or had significant blood loss within 56 days prior to dosing of study drug.
Plasma donation within 28 days prior to dosing of study drug.
Is or has an immediate family member (e.g., spouse, parent/legal guardian, sibling or child) who is investigational site or Sponsor staff directly involved with this study.
Participation in another clinical trial within 28 days prior to dosing.