Intervention: SODIUM CHLORIDE
Trial phase: Phase 4
ATC code: A12CA01 | B05CB01 | B05XA03 | S01XA03
SMILES: [Cl-].[Na+]
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: No
Participants at risk: 9
Group description: Bacteriostatic 0.9% Sodium Chloride (vehicle): Intramuscular injection
Eligibility criteria:
Inclusion Criteria:

Patients must meet all of the following inclusion criteria to be eligible for enrollment:

Ability to understand the risks, benefits, and alternative to participation and give informed consent
Have biopsy proven skin cancer on the medial forehead that is amenable to Mohs surgery. Medial forehead is defined as the area superiorly from the hairline, inferiorly at the eyebrow, and laterally to the tip of the lateral brow (see diagram).
Undergoing elective reconstruction of biopsy proven skin cancer that is amenable to Mohs surgery with defect size measuring 1.0 cm or greater
If female, not currently pregnant, no potential for pregnancy, or if of child-bearing age, must agree to use adequate contraception (e.g., hormonal or barrier method of birth control; abstinence) for 30 days after the last dose of study drug. A negative urine pregnancy test is required at study entry for female subjects of childbearing potential: a woman is considered to be of child bearing potential unless she has had a tubal ligation, total hysterectomy, bilateral oopherectomy, or is postmenopausal (without a menstrual period for at least one year)
Agrees to not use disallowed concomitant medications (retinoids)

Exclusion Criteria:

The presence of any of the following will exclude a patient from study enrollment.

Pregnant women, women who are breastfeeding, or women of child bearing age who are unwilling to use adequate contraception (described above) during the study period
Current or past history of a neuromuscular disease (such as myasthenia gravis, amyotrophic lateral sclerosis, Eaton-Lambert syndrome)
Currently taking aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like agents)
History of radiation therapy or chemotherapy
History of keloid or other hypertrophic scar formation
Current or past history of scleroderma
Has used botulinum toxin in the forehead area within one year.
Has significant resting eyebrow ptosis
Has used any topical retinoids to the forehead area within the past 4 weeks
Undergo any scar revision procedure for the duration of the study including intralesional kenalog, laser treatment, and/or scar revision surgeries
Any hypersensitivity to any component of abobotulinumtoxinA (i.e. cow milk protein) or any previous hypersensitivity to any botulinum toxin A or related product.
Non-English speaking: These patients are excluded since translation of the informed consent into other languages is time-consuming and expensive as it requires a bona fide translator for the particular language of interest and this type of person may be difficult to locate.
House staff and students, medical students on a clerkship, and employees related to study personnel or who work for any study personnel, and members of the study team are not eligible to participate in this study as a subject.
The investigator feels that for any reason the subject is not eligible to participate in the study