Intervention: Ganetespib
Trial phase: Phase 2
SMILES: CC(C)c1cc(-c2n[nH]c(=O)n2-c2ccc3c(ccn3C)c2)c(O)cc1O
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: No
Participants at risk: 1
Group description: Patients enrolled into two possible cohorts based on tumor expression of BRAF: Cohort A - BRAF mutant disease or Cohort B - BRAF wild type. Cohort A patients received STA-9090 200 mg/m2 once weekly (d1, 8, 15 of 28 day cycle). Patients were treated until evidence of disease progression, unacceptable toxicity, intercurrent illness or withdrawal.
Eligibility criteria:
Histologically confirmed unresectable stage III or stage IV melanoma
Treatment of unresectable stage III or stage IV melanoma with a tyrosine kinase inhibitor within prior 4 months. Sorafenib for purposes of eligibility will not be considered acceptable prior therapy
Sufficient tumor available to determine if expresses wild-type or mutated BRAF if result not already known. The presence or absence of BRAF mutation needs to be determined at BWH, MGH, BIDMC, by Drs. Christopher Corless and Michael Heinrich at Cancer Pathology Shared Resource Oregon Health & Science University, or in context of eligibility assessment after signing consent to a previous clinical trial
Sufficient tumor available to determine if expresses a mutation KIT
Agreement to allow tumor to be evaluated for mutations in KIT and BRAF
ECOG performance status ≤ 1
Life expectancy of ≥ 6 months
Age ≥ 18 years
WBC ≥ 3 x 103/ul
ANC ≥ 1,500/ul
Platelets ≥ 100 x 103/ul
Hemoglobin ≥ 9 gm/dl
Serum creatinine ≤ 1.5 x ULN
Calculated creatinine clearance ≥ 60 mL/min
AST ≤ 2.5 x ULN; -OR- AST ≤ 5 x ULN in the presence of known liver metastases
ALT ≤ 2.5 x ULN; -OR- ALT ≤ 5 x ULN in the presence of known liver metastases
Total bilirubin ≤ 1.5 x ULN
Potassium within normal range or correctable with supplements
Magnesium within normal range or correctable with supplements
Corrected serum calcium within normal range, or correctable with supplements
Not pregnant or breastfeeding. Female subjects of childbearing age must have a negative serumpregnancy test at study entry
Women of childbearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation and for 6 months following last study drug administration
Agreement to provide blood samples for pharmacodynamic studies utilizing Peripheral Blood Mononuclear Cells (PMBCs) as outlined in protocol
At least one site of measurable disease as defined by at least 1 cm in greatest dimension. This site must be different from the sites to be used for biopsy. No prior radiation therapy or directed ablation to the site of measureable disease
Able to understand and willing to sign a written informed consent document
Willing and able to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures
No chemotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to study entry
No radiotherapy within 4 weeks prior to study entry
Subject has recovered from adverse events due to agents administered more than 4 weeks earlier
No tyrosine kinase inhibitor within 14 days prior to study entry
No major surgery within 4 weeks prior to first dose of STA-9090
No minor surgery within 7 days of first dose of STA-9090
No history of or current coronary artery disease, myocardial infarction, angina pectoris, angioplasty
or coronary bypass surgery
No current treatment with the following antiarrythmic drugs: flecainide, moricizine or propafenone
No NYHA class II/III/IV congestive heart failure with a history of dyspnea, orthopnea, or edema that requires current treatment with angiotensin convering enzyme inhibitors, angiotensin II receptor blockers, beta-blockers, or diuretics
No current or prior radiation to the left hemithorax
No embolization procedure or ablation procedure to treat tumor within 4 weeks of first dose of STA- 9090
Not receiving any other investigational agents
No poor venous access for study drug administration unless subject can use silicone based catheters
No history of brain metastases or of leptomeningeal involvement
No history of severe allergic reactions or hypersensitivity reactions attributed to compounds of similar chemical or biologic composition to STA-9090 (e.g. olyethylene glycol [PEG] 300 or Polysorbate 80)
Baseline QTc ≤ 470 msec
No previous history of QT prolongation while taking other medications
Ventricular ejection fraction (EF) > 55%
No treatment with chronic immunosuppressants
No melanoma of ocular primary
No prior treatment with hsp90 inhibitor
No uncontrolled intercurrent illness including, but not limited to ongoing or active infection, ventricular arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
No other medications, or severe acute/chronic medical of psychiatric conditions or laboratory abnormality that may increase the risk associated with the study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the subject inappropriate for entry into the study
No history of a different malignancy except for the following circumstances. Individuals with a history of other malignancies are eligible if they have been disease-free for at least 5 years and are deemed by the investigator to be at low risk for recurrence of that malignancy. Individuals with the following cancers are eligible if diagnosed and treated within the past 5 years: cervical cancer in situ, and basal cell or squamous cell carcinoma of the skin
No HIV-positive subject on combination antiretroviral therapy
No more than 3 prior systemic therapies for unresectable stage III or stage IV melanoma
No concomitant use of medications associated with a high incidence of QT prolongation as outlined