Intervention: HYDROGEN PEROXIDE
Trial phase: Phase 2
ATC code: A01AB02 | D08AX01 | D11AX25 | S02AA06
SMILES: OO
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: No
Participants at risk: 17
Group description: A-101 40% with the identified DPN lesions medically abraded prior to treatment

A-101 Topical Solution 40%: A-101 Topical Solution 40%
Eligibility criteria:
Inclusion Criteria:

Provisions of written informed consent for participation in this study.
Male or female ≥ 18 years old.
Subject has a clinical diagnosis of dermatosis papulose nigra.
Fitzpatrick Skin Type of 5 or 6
Subject has 4 target DPN lesions located in an area that has not been previously treated.
Subject chemistry and complete blood count results are within normal limits for the central laboratory.
Woman of childbearing potential must have a negative urine pregnancy test within 14 days of the first application of study drug and agree to use an active method of birth control for the duration of the study
Subject is non-pregnant and non-lactating.
Subject is in good general health and free of any known disease state or physical condition.
Subject is willing and able to follow all study instructions and to attend all study visits.

Exclusion Criteria:

Subject has clinically atypical and /or rapidly growing DPN lesion.
Subject has current systemic malignancy.
Subject has a history of keloids
Subject has a history of post inflammatory hyperpigmentation lasting longer than 1 year.

Subject has used any of the following systemic therapies within the specified period prior to Visit 1:

Retinoids; 180 days
Corticosteroids; 28 days
Antimetabolites (e.g., methotrexate); 28 days

Subject has used any of the following topical therapies within the specified period prior to Visit 1 on, or in a proximity to any Target Lesion, that in the investigator's opinion interferes with the study medication treatment or the study assessments:

LASER, light or other energy based therapy (e.g., intense pulsed light [IPL], photo-dynamic therapy [PDT]; 180 days
Liquid nitrogen, electrodesiccation, curettage, imiquimod, 5-fluoruracil (5FU), or ingenol mebutate; 60 days
Retinoids; 28 days
Microdermabrasion or superficial chemical peels; 14 days
Corticosteroids or antibiotics; 14 days.

Subject currently has or has had any of the following within the specified period prior to Visit 1 on or in a proximity to any Target Lesion that, in the investigator's opinion, interferes with the study medication treatment or the study assessments:

Cutaneous malignancy; 180 days
Sunburn; currently
Pre-malignancy (e.g. actinic keratosis); currently
Body art (e.g. tattoos, piercing, etc.); currently
Excessive tan. The use of self-tanning lotions/sprays are prohibited.
Subject has a history of sensitivity to any of the ingredients in the study medications.
Subject has any current skin disease (e.g. psoriasis, atopic dermatitis, eczema, sun damage), or condition (e.g. sunburn, excessive hair, open wounds) that, in the opinion of the investigator, might put the subject at undue risk by study participation or interfere with the study conduct or evaluations.
Participation in another therapeutic investigational drug trial in which administration of an investigational study medication occurred with 30 days prior to Visit 1.