Intervention: Verapamil
Trial phase: Phase 1 | Phase 2
ATC code: C08DA01 | C08DA51 | C09BB10
SMILES: COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: Accepts Healthy Volunteers
Participants at risk: 81
Group description: Subjects will be randomized to receive a single injection of IA Verapamil or IA Placebo at a ratio of 1:1.

Verapamil
Eligibility criteria:
Inclusion Criteria:

Subjects must meet all of the following inclusion criteria to participate in the study:

Be 35-75 years of age and in good general medical and psychological health.
Be able to speak, read, write, and understand English, understand the consent form, complete study-related procedures, and communicate with the study staff.

Have OA of at least 1 knee (target knee) for at least 6 months and meet all the following criteria:

OA documented by standing X-rays anterior-posterior patella-femoral view taken within 1 month of screening visit indicating Kellgren-Lawrence Grade 2 to early-stage Grade 4 radiographic stage of the knee;

Have pain associated with OA of the target knee for at least 25 of the last 30 days; c. Meet the American College of Rheumatology clinical classification criteria, defined as having pain in the target knee and at least 3 of the following 6 items:

Age > 50;
Morning stiffness <30 minutes;
Crepitus on active motion;
Bony tenderness;
Bony enlargement;
No palpable warmth of synovium.
Target knee does not have any type of orthopedic and/or prosthetic device.
Based on standard physical examination of the target knee, does not have any neurovascular deficits, any skin abnormalities, any meniscal abnormalities, or any ligament instability.
At treatment visit 2 prior to randomization, have a score of at least 20 on the WOMAC pain subscale (questions 1-5) for the target knee and an in-clinic average pain intensity score of at least 4/10 on the 0-10 NRS for the 24-hour recall.
Be willing to maintain any present stable treatment modalities (e.g., acupuncture or physical therapy) and be willing to refrain from initiating any new treatment modalities.
Be willing to stop taking nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids for the duration of the study.
If female of child-bearing potential (ie, not medically or surgically sterilized or not post-menopausal more than 1 year) or fertile male with sexual partner of childbearing potential, be willing to use adequate and reliable contraception throughout the study (eg, abstinence or barrier with additional spermicidal foam or jelly, or the use of intrauterine device or hormonal contraception by female subjects and partners of male subjects).
Not be enrolled in any other clinical trial and not have used any investigational drug within 1 month.

Exclusion Criteria:

Subjects who meet any of the following criteria will not be eligible to participate:

Have a Kellgren-Lawrence Grade 1 radiographic stage of the knee or have Kellgren-Lawrence Grade 4 radiographic end stage of the knee with bone on bone, ie, less than 2 mm joint space.
Be a candidate for knee replacement within next 6 months.
Have a body mass index > 35 kg/m2.
Have a Hospital Anxiety and Depression Scale score >12 on either subscale or have an established history of major depressive disorder not controlled with medication.
Have, in the Investigator's opinion, clinically significant abnormalities in clinical laboratory tests (hematology, clinical labs, urinalysis).
Have a positive urine drug test for illegal drug substances at screening.
Have, in the Investigator's opinion, clinically significant abnormalities in electrocardiogram readings
If a female of childbearing potential, have a positive pregnancy test at screening.
Have significant pain outside the target knee, including significant hip or back pain (bilateral knee OA will be allowed as long as target knee pain can be distinguished from contralateral knee pain and contralateral knee does not require treatment).
Have pain affecting the target knee that is due to any etiology other than OA.
Have documented history of inflammatory arthritis, including rheumatoid arthritis.
Have a meniscal tear in the target knee.
Have had viscosupplementation with hyaluronic acid products within 6 months prior to screening.
Have failed to respond to prior treatment with viscosupplementation with hyaluronic acid products.
Have had IA corticosteroid injections within 12 weeks or intramuscular or oral steroids within 4 weeks prior to screening.
Have had surgery of the target knee within 6 months prior to screening.
Have used opioids 4 or more days per week during in the past month prior to screening.
Are allergic to, or intolerant of, acetaminophen.
Have used verapamil within the past 4 weeks or are allergic or intolerant to verapamil.