Intervention: Lanreotide
Trial phase: Phase 2
ATC code: H01CB03
SMILES: CC(C)C1NC(=O)C(CCCCN)NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(NC(=O)C(N)Cc2ccc3ccccc3c2)CSSCC(C(=O)NC(C(N)=O)C(C)O)NC1=O
Sex: All
Age groups: Adult | Older Adult
Healthy volunteers: No
Participants at risk: 9
Group description: Open label

Lanreotide: Dosage: 120mg Dosage form: subcutaneous injection, pre-filled syringe Dosage frequency: 3 injections over 12 weeks, each dose administered 4 weeks apart
Eligibility criteria:
Inclusion Criteria:

Consecutive patients with evidence of small bowel motility disorders, referred to (or) are patients of the Gastroenterology and Motility Center at Northwell Health System.
Aged between 18 and 70 years.
Subjects should be capable of understanding the study and be able to give informed consent.
Patient having small bowel motility disorder as evidenced by delayed small bowel transit by wireless motility capsule (WMC) testing to > 6 hours.
To participate in the study, patients will have to stop taking Octreotide (because it has the same mechanism of action as the study medication) if they are currently taking it; it should be stopped for at least 4 weeks before taking the first dose of this study medication.

General Exclusion Criteria

Age <18 or age >70
Pregnancy as assessed by urine pregnancy test.

Exclusion Criteria for performing wireless motility capsule testing

History of gastric bezoar
History of Disorders of swallowing
Known or suspected small bowel diverticula, diverticulitis, strictures, fistulas, Crohn's disease, or any other relevant medical comorbidity (e.g. chronic alcohol abuse)
Prior intestinal surgery, including Ileocecal(IC) valve resection or gastrointestinal surgeries that create a blind loop (e.g. Bilroth II or Roux-en-Y)
History of Severe dysphagia to food or pills
A participant who uses an implanted or portable electro-mechanical medical device such as a cardiac pacemaker or infusion pump
Inability to be off intestinal transit altering medication for at least one week (e.g. opiates, laxatives, etc.)
Any person unable or unwilling to undergo abdominal surgery.
BMI > 40.

Exclusion Criteria due to Lanreotide

Current use or recent (within last 7 days) use of acid suppressive therapy, prokinetic agents, laxatives, and opiates, or other agents known to affect gastrointestinal motility.
Disorders associated with presumed small intestinal motility disorders including: scleroderma, intestinal pseudo-obstruction, and autonomic visceral neuropathy (e.g. longstanding diabetes of more than 20 years and/or poorly controlled diabetes (glucose > 250, glycosylated hemoglobin (HbA1c) > 8.5%)
Current use of cyclosporine (Gengraf, Neoral, or Sandimmune), a medicine called bromocriptine (Parlodel, Cycloset), or medicines that lower heart rate, such as beta blockers.

Cardiac arrhythmia based on health history (palpitations, feeling a pause between heartbeats, lightheadedness, passing out, shortness of breath, or chest pain).

Bradycardia and Tachycardia are monitored during every visit to the clinic, using pulse rate.

ECG will be performed during screening visit and during 8th week of the study. The following are accessed with ECG.

Bradycardia <60 beats/min.
Tachycardia >100 beats/min.
Atrial Fibrillation - Rapid irregular atrial signal with no real P-waves and irregular ventricular rate.
Ventricular Fibrillation - Irregular ventricular waveforms.
Sinus Arrhythmia - Normal beats, but triggered at an irregular interval from 60 to 100 beats per minute, causing varying R-R interval.
Missed beats.
Chronic kidney disease (moderate and severe renal impairment as calculated by creatinine clearance of <50 mL/min)
Hepatic Impairment - Subjects with Child-Pugh Class B and Class C.
Significant electrolyte abnormalities: Anything outside of the normal range by +/- 20 % will be considered as abnormal.
Cholelithiasis (Total bilirubin >2x of normal)
Pancreatitis
Hepatitis (Aspartate transaminase (AST), Alanine transaminase (ALT) or Alkaline phosphatase (Alk Ph), greater than upper limit of normal(ULN), Serum albumin <3.0 g/dL unless prothrombin time is within the normal range)
Present cholecystitis
Uncontrolled congestive heart failure
Known hypersensitivity to the study drug