Intervention: Rigosertib
Trial phase: Phase 2
SMILES: COc1cc(OC)c(/C=C/S(=O)(=O)Cc2ccc(OC)c(NCC(=O)O)c2)c(OC)c1
Sex: Female
Age groups: Adult | Older Adult
Healthy volunteers: No
Participants at risk: 1
Group description: 3200 mg ON 01910.Na administered intravenously over 2 hours on days 1, 4, 8, 11, 15, and 18 of 28-day cycle
Eligibility criteria:
Inclusion Criteria:

Women with ovarian cancer at least 18 years old with measurable disease who have shown recurrent disease within 6 months of the last dose of cisplatin- or carboplatin-based chemotherapy. Measurable disease will be defined as lesions that can be accurately measured in at least one dimension with longest diameter ≥ 20 mm using conventional techniques or ≥ 10 mm with spiral CT scan.
Eastern Cooperative Oncology Group (ECOG) Performance Status 0, 1 or 2.
No more than 3 prior chemotherapy regimens.
Disease-free period of more than 5 years from prior malignancies other than ovarian (except curatively treated basal cell carcinoma, squamous cell carcinoma of the skin,or carcinoma in situ of the cervix).
All female patients of childbearing potential must use at least one form of contraception as approved by the Investigator prior to study entry and for up to 30 days beyond the last administration of study drug.
Women of childbearing potential must have a negative serum βHCG pregnancy test at screening.
Willing to adhere to the prohibitions and restrictions specified in this protocol.
Patient (or her legally authorized representative) must have signed an informed consent document.

Exclusion Criteria:

Evidence of complete or partial bowel obstruction.
Need for IV hydration or Total Parenteral Nutrition.
Inability to comply with study and/or follow-up procedures.
Life expectancy of less than 12 weeks.
Prior radiotherapy to greater than one third of hematopoietic sites.
Uncontrolled intercurrent illness including, but not limited to symptomatic congestive heart failure, unstable angina pectoris or cardiac arrhythmia.
Active infection not adequately responding to appropriate therapy.
Hyponatremia (defined as serum sodium value of <134 mEq/L).
Total bilirubin ≥ 1.5 mg/dL not related to hemolysis or Gilbert's disease, AST/ALT or alkaline phosphatase ≥ 2 X ULN.
Serum creatinine ≥ 2.0 mg/dL.
ANC < 1500/mm3, platelets < 100,000/mm3; hemoglobin less than 9 g/dL.
Ascites requiring active medical management including paracentesis for more than twice a month.
Women patients who are pregnant or lactating or have a positive serum βHCG pregnancy test at screening.
Major surgery without full recovery or major surgery within 3 weeks of ON 01910.Na treatment start.
Uncontrolled hypertension (defined as a systolic pressure ≥ 160 and/or a diastolic pressure ≥ 110).
New onset seizures (within 3 months prior to the first dose of ON 01910.Na) or poorly controlled seizures.

Brain metastases including any of the following:

Evidence of cerebral edema by CT scan or MRI.
Evidence of disease progression on prior imaging studies.
Requirement for steroids.
Clinical symptoms of brain metastases.
Any concurrent and/or within 4 weeks of the first dose of study drug investigational agent or chemotherapy, radiotherapy or immunotherapy.
Psychiatric illness/social situations that would limit the patient's ability to tolerate and/or comply with study requirements.