Intervention: INSULIN DETEMIR
Trial phase: Phase 4
ATC code: A10AE05
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Sex: All
Age groups: Older Adult
Healthy volunteers: No
Participants at risk: 38
Group description: Individually adjusted dose of insulin detemir once daily
Eligibility criteria:
Inclusion Criteria:

Type 2 diabetes
Insulin naive
Treatment with oral anti-diabetic drugs (OADs) for at least 3 months and not achieving therapeutic targets
HbA1c between 8% - 10.5%

Exclusion Criteria:

Secondary diabetes, MODY (Maturity Onset Diabetes of the Young)
Previous treatment with insulin (except for short-term treatment with insulin for intercurrent illness as judged by the Investigator)
Proliferative retinopathy, maculopathy requiring treatment,
Hypoglycaemia unawareness as judged by the Investigator, recurrent major hypoglycaemia
End stage liver disease (increased liver enzymes 4 fold), end stage renal disease assessed by MDRD (Modification of Diet in Renal Disease) less than 30 ml/min or dialysed patient, acute heart failure, any acute cardiovascular event or cerebrovascular event less than 6 months
Acute disease with poor prognosis
History of alcoholism, drug abuse, or psychiatric disease or personality disorders likely to invalidate voluntary consent or to prevent good compliance with the trial protocol
Mental incapacity, unwillingness or language barrier precluding adequate understanding or co-operation (patients having a score of less than 15 in a previous MMSE (Mini-Mental State Examination) in the last six months) and any conditions as judged by the investigator
Legal incapacity or limited legal capacity (patients under guardianship or curatorship)
Concomitant medication for Alzheimers treatment (Memantine, Anticholinesterasique treatment)
Participation in another clinical trial less than one month before inclusion in this trial
Illness requiring repeated hospitalisation
Known or suspected allergy to the insulin or any compositional component
Anticipated change or new use in concomitant medication known to interfere with glucose metabolism, such as systemic corticotherapy more than 5 mg/day (prednisone)
Any other condition that the Investigator feels would interfere with trial participation or evaluation of results
Terminal illness