Document type: Resume

FF Principal Investigator/Program Director: Samuel E. George, M.D. BIOGRAPHICAL SKETCH Give the following information for the key personnel and consultants and collaborators Begin with the principal investigator/program director. Photocopy this page for each person. GEORGE, Samuel Everett Assistant Professor EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) YEAR DEGREE CONFERRED BA 1976 Biochemistry MD 1980 Medicine Univ. of Utah, Salt Lake City, UT Fiecent 4982-85 Internal Medicine Baylor Coll. of Med., Houston, TX 1985-87 Cardiology RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience and honors. Key personnel include the principal investigator and any other individuals who participate in the scientific development or execution of the project. Key personnel typically will include all individuals with doctoral or other professional degrees, but in some projects will include individuals at the masters or baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on any Federal Govemment public advisory committee. List, in chronological order, the titles, all authors, and complete references to all publications during the past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. INSTITUTION AND LOCATION FIELD OF STUDY Univ. of California, Berkeley, CA Washington Univ. St. Louis, MO 1980-82 Research Fellowship, Department of Medicine, Division of Cardiology, Washington University School of Medicine, St. Louis, MO 63110, 1982-85 Residency in Internal Medicine, Department of Medicine, University of Utah College of Medicine, Salt Lake City, UT 84112. 1985-87 Clinical Cardiology Fellow, Baylor College of Medicine, Houston, Texas 77030. 1987-89 American Heart Association-Bugher Foundation Research Fellow, Baylor College of Medicine, Houston, TX 77030. 1989-91 Assistant Professor, Department of Medicine, Division of Cardiology, Baylor College of Medicine, Houston, TX 77030. 1991-present Assistant Professor, Departments of Medicine and Pharmacology, Cardiovascular Division, Duke University Medical Center, Durham, NC 27710. Honors and Awards Fellow, AHA-Bugher Foundation for Molecular Biology in Cardiovascular Diseases, 1987-89; Clinical Investigator Award, NHLBI, 1990-93; American Heart Association, Western Regional Peer Review Committee, 1990-92; American Heart Association, North Carolina Affiliate Research Review Subcommittee, 1992-94; Henry Christian Award for Excellence in Research, American Federation for Clinical Research, 1993 (Neuroscience); American Heart Association, North Carolina Affiliate Research Oversight Committee, 1995-98; Established Investigator, American Heart Association, 1995-2000. Professional Societies Diplomate, American Board of Internal Medicine, 1985 (Cardiovascular Disease, 1987); Basic Science Council, Clinical Council, American Heart Association; American Federation for Clinical Research. Publications George, S. E., Ishikawa, Y. L, Perryman B., and Roberts, R. (1984) Purification and characterization of naturally occuring and in vitro induced multiple forms of MM-creatine kinase. J. Biol. Chem. 259, 2667-2674. Kleiman, N., Verani, M., George, S. E., Lawrie, G. (1987) Pericardial constriction and right to left shunting following coronary artery bypass surgery. Am. Heart J. 114, 431-433, Verani, M., George S. E., Leon, C., Whisennand, J., Noon G., Short D., DeBakey, M. E., and Young, J. (1988) Systolic and diastolic ventricular performance at rest and during exercise in heart transplant recipients. J. Heart Transplant. 7, 145-151. Means, A. R., and George, S.E. (1988) Calmodulin regulation of smooth muscle myosin light chain kinase. J. Cardiovascular Pharmacology 12, $25-29.