Document type: Resume

BIOGRAPHICAL SKETCH ~ Give the following informaticn for the kay personnel and conauitants ligted on page 2. Beyin with the Prinetpat Inveatiqator/Program Ohecter, Photocopy tng Page for wach person FF __PRINCIPAL INVESTIGATORIPROGRAM OinecTor: Victor A. Fried, Ph.D AME POSITION TITLE ~ ” TBIRTHDATE (Mo. Day, yr) Victor A, Fried Professor 9/23/43 wit reale oF other inital professional education, sucli a8 nursing, and meiuce postaoetoral training.) INSTITUTION AND LOCATION DEGREE ee — i on CONFERRED FIELO OF STUDY niversity of Chicago, Chicago, IL _ BS 1965 P ¢ : University of Oregon, Eugenes, OR Ph.D, 1970 Biochontareentt? Dagwersity of Oregon, Eugene, OR Postdoc 1970-73 Genet. /Mol, Biolog niversity of Connecticut, farmington Postdoc 1973-75 Membrane Blochemiatr Health Science Center ae i ce? ih RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with prasant puyition, Ils, in chronalagical order, previous smployenant; experience and honors. Include present membership on any Federal Government public advisory Committe. Lisi, In chronological ordar, the (itles and can plete references to alt publications during the past three years and to represaniative earli Heali i EXGEED UNE PRES p ier publi¢alions pertinent to this application. DO NUT 1975-81 Assistant Professor, Dept. of Microbiology, Univ. of Pittaburgh School ef Medicine, Pitteburgh, PA 1981 Research Aseiatant Professor, Dept. of Biological Sciences, Faculty of Arta and Sclences, Univ. of Pitteburgh, PA 1981-84 Assistant Member, Dept. of Blochemistry, St. Jude Childran’s Research Hospital, Memphia, TN 1984-90 Associate Member, Dept. of Biochemistry, St. Jude Children’s Research Hospital, Memphis, TN 1984-90 Director of Protein Structure Facility, St. Jude Children’s Research Hoapltal, Memphis, TN 1990-Pre Professor, Cell Blology & Anatomy, NY Medical College, Valhalla, HY Selected Publications MeKnight, J.L., and Fried, V.A. A novel proteolytic activity apparently initiating dagradation of B-galactosidase nonsense fragments in in vitro extracts of BE. coli. J. Biol. Chem. 258:7550-7555, 1983. Fried, V.A., Ando, M.E., and Bell, A.J. Protein quantitation at the Picomol level: An o-phthaldialdehyde-pra TSK column derivitization assay. Anal. Biochem. 146:271- 276, 1985. Siegelman, M. Bond, M.W., Gallatin, W.M., St. Jonn, T., Smith, H.T., Fried, V.A., arid Weiseman, I.L. Cell surfaca moleacula aggociated with lymphocyte homing ia a ublquitinated branched chain glycoprotein. Seience 231:823-829, 1986. St. John, T., Gallatin, W.M., Slegalman, M., Smith, H.T., Fried, V.A., and Weiasman, I.L. Expression cloning cf a lymphocyte homing receptor cDNA: Ubiquitin is the Feactive apecies. Science 231:845-850, 1986. Yarden, ¥., Bxcobedo, J.A., Kuang, W-J., Yang-Feng, T.L., Daniel, T.O., Tremble, P.M., Chen, E.¥., Ando, M.E., Harkins, R.A., Francke, U., Fried, V.A., Ullrich, A., and Williams, L.T. Structure of tha receptor for platelet~derlved growth factor helps define a family of closely related growth factor receptors. Nature 323:226-232, 1986. Deshpande, K.L., Fried, V.A., Ando, M.E., and Webster, R.G. Glycosylation affects Cleavage of an H5H2 influenza virus hemagglutinin and regulates virulence. Proc, Natl. Acad. Sci. USA 84:36-40, 1987, Wang, S.S., and Fried, V.A. Early steps initiating a degradation pathway in Be cols: Characterization of the first intermediate, J, Biol. Chem. 262:36357-6374, 1987, Fried, V.A., Smith, H.T., Hildebrandt, E., and Weiner, K. Ubiquitin hap intrinaie proteolytic activity: Its implicationa for cellular regulation. Proc. Natl. Acad. Sei. USA 84:3685-3689, 1927. Winkler, M.A., Fried, V.A., Merat, D.L., Cheung, W.Y. Differential reactivities of lysines in calmodulin complexed to phosphatase. J. Biol, Chem. 262)15466-15471, 1987. PHS 398 (Rev. 10/88) (Reprinted 9/89} “Number cages raneanitivaly at the Kaine then. abe ee coe eee