anirudh1112/corrected-tobacco-dataset-with-ocr huggingface dataset:
Document type: Email

2084391924 From: Ostern, Eric [mailto:Eric.D.Ostern@pmusa.com] Sent: Wednesday, February 21, 2001 6:48 PM To: Mao, Yugian Y.; Manning, Michelle P. Cc: ‘Cavicchio, Carolyn’ Subject: FW: YSP Conference Please work w/ Michelle to get on my calendar for next Wed to discuss---also, let's include Carolyn Cavicchio so we can discuss--- Michelle, please coordinate a 1 hr. meeting w/ me, CC, and Yen. Thanks- Eric Ostern, Manager, Youth Smoking Prevention Programs
Document type: Report

RJR CONFIDENTIAL DISCRIMINATION [4 OTHER. C] SENSORY EVALUATION DIVISION SY DESCRIPTIVE [] TEST REPORT NO. 226 _ piaGnostic §=« [_] PROJECT: Flavored Triacetin Plasticizer Study - WINSTON Light 100 Box TEST: Non-Menthol Discrimination YEAR OF REPORT: 1987 NO. OF PAGES: 5. OBJECTIVE: To determine if there is a perceptual difference between the current WINSTON Light 100 Box product and a WINSTON Light 100 Box prototype which has tow item made with additional flavorants added to the triacetin. SUMMARY AND CONCLUSION: Recently WINSTON Light 100 Box product was produced using either tow item or box material which had a high level of residual acetone. This product gave an “off" odor upon opening of the box. The Flavor Division recommends the addition of flavors to the WINSTON Light 100 Box tow item in order to mask high levels of residual acetone, should they occur in the product in the future. Discrimination results showed there was no perceptual difference between the current WINSTON Light 100 Box product and a WINSTON Light 100 Box prototype which has tow item made with additional flavorants added to the triacetin. These results show that the addition of the flavorants will not change the perception of the WINSTON Light 100 Box product, but does not indicate whether or not the additional flavorants would mask any “off" odors caused by high levels of residual acetones. STATUS: Sensory testing of the products was completed on September 14, 1987. Brands Development and the Flavor Division are investigating the possibility of creating products with high level of residual ecetone, in order to "create the problem" again. Half of the prototypes made with high levels of residual acetone will have no flavorants added to the triacetin and the other half will have the flavorants added. These two prototypes will then be submitted for discrimination testing. The hypothesis being that if the added flavorants mask the "off" odor the products should be perceptually different. This test would then be followed up with descriptive testing in order to describe and quantify these differences. KEYWORDS: triacetin, discrimination, WINSTON Light 100. Box, flavors, plasticizer, non-menthol, sensory evaluation O2ZZE 8S90S
Document type: Letter

‘WOMBLE CARLYLE SANDRIDGE & RICE A PROFESSIONAL LIMITED LIABILITY COMPANY, Mr. Jerry Williams 150 Fayetteville Street Mall, Suite 2100 Raleigh, NC 27601 Moiling Address Post Office Box 83! Raleigh, NC 27602 E. Lawrence Davis III Telephone: (919) 755-2100 Direct Dial: (919) 755-2103 Fax; (919) 755-2150 Direct Fax: (919) 755-6060 E-mail: |_davis@wesr.com December 4, 1996 North Carolina Restaurant Association Post Office Box 6528 Raleigh, North Carolina 27628 Re: Dear Jerry: Halifax County Board of Health Smoking Regulations The following is a list of the individuals to whom we have sent a letter and copy of the decision handed down by the North Carolina Court of Appeals on December 3, 1996 in the case of the City of Roanoke Rapids, et al. v. C: Douglas Peedin, Jr., et al. Wer ANWR WN Wayne F. Abele, Shoneys, Stuart Adcox, Chairman of the Wake County Board of Commissioners; Dusty Anderson, Vinnie’s Steakhouse and Tavern; John Converse, Wake County Commissioner, Van Eure, Agnus Barn; Brad Hurley, 42nd Street Oyster Bar, Jim Matthews, Carroll’s Foods, Inc.; Gary Pendleton, former Wake County Commissioner; Jackie Watkins, Raleigh Farmers Market Restaurant, Inc.; Steve Webb, Snead’s Ferry; Wayne Willard, Chairman Forsyth County Board of Commissioners; and Debbie Wray-Holt, Coopers Barbecue. Ifyou are aware of others to whom we need to send the letter and decision to please let me know. With best regards, ] am Yours sincerely, WOMBLE CARLYLE SANDRIDGE & RICE A Professional Limited Liability Company ff Lawrence Davis, II ac, Gricfins uw RHO200659.01 arLaNTta CHARLOTTE ¢ RALEIGH / RESEARCH TRIANGLE PARK / WINSTON-SALEM Z6TT FZ8TS
Document type: Letter

LAHTRILE IS LEGALLY DEAD NOW IN THe US BUT IT IS VERY MUCH ALIVE IN CANADA AND MEXICO, HOW DUMB CAN ONE GET? JOHN BEARD MEMORIAL FOUNDATION PONT OFFICE BOK 685 SAN FRANCINCO 1, CALIFORNIA VAuenora 41067 September 7, 1962 K i pe F nc D stopped the rebs Labs from making Laetrile and Dr. Howard H, Beard BLS about 2 months ago due to the Beard Biochemical Laboratory fact that the lab did not make 5220 Locke Avenue application for a new license to Fort Worth, Texas make these products. This letter given below from Dr. E.T.Krebs, Jr Dear Howard: gives the position of this matter as of September, 7, 1962. HHB, Many thanks for your letter of 30 August. I have been so busy of late that I have neglected writing my very best friends, most trusted associates, and loyal Beardians. Like the prophet, Abdullah, you head the list. One filing about sixty days ago was made with the Federal Food and Drug Administration, This consisted of about nineteen pages and could be considered a memorandum of information. Notice has been received that this filing is incomplete. I have prepared another fil- ‘ing that will amount to almost 400 pages, and I trust that this filing will be considered complete. The statutory limit for notification on a filing is sixty days, as you know; however, in some cases noti- fication is given earlier than this. You can advise your physician friends that a new drug application of almost 400 pages has been made to the Federal Food and Drug Admin- istration and that a similar filing will be made with the corresponding California agency within the next few days. I want to thank you for your intense and continuing efforts in the cause of Beardlanism. I appreciate very much what you say about the pressure you are receiving from doctors, since we are feeling a bit of this ourselves. As I may have told you, Doctor M.W. McDougall of 529 Bast 10th Street, Long Beach, California, is working on the Beard Anthrone - Test. Perhaps you would like to drop him a line to welcome him to the club, Cordially yours, | ~y. KA _ Ernst T. Krebs, Jr. JOHN BEARD MEMORIAL FOUNDATION K/1t
Document type: Letter

THE COUNCIL FOR TOBACCO RESEARCH-U.S.A., INC. i RE SUPPORTING BIOMEDICAL INVESTIGATION : . , ; 900 THIRD AVENUE ‘ New Yor«, NY 10022 . (12) 421-8885 GEORGE A. HASHM™, PH.D: ABBOCIATE RESEARCH DIRECTOR _ October 17, 1995 . Dr. Alan Chait Division of Metabolism Department of Medicine University of Washington Box 336026. Re: #4388 Seattle, WA 98195-6426 Subject: The 1996 Deuel Conference on Lipids -- Date: March 5-8, 1996 ~ Location: Borrego Springs, CA-. Dear Dr. Chait: The Scientific Director and CTR's staff have discussed your request for partial support of the conference named above. The program contains topics of interest to the Council, and the list of speakers ensures the scientific quality of the meeting. Iam pleased to inform you that we will make a contribution of $2,000 to help defray, in part, the costs . of the conference. A check for the noted amount, payable to The 1996 Dueul Conference. on Lipids is enclosed for your attention. It would assist fn our record-keeping if we could have a written acknowledgment of the contribution. We request only that these funds not be used to seimibHs expenses incurred by participants from the industrial sector... Sincerely yours, LI? KEP - George. = Haskins cc; ‘Dr. H. McAllister file 3 = Sms ROK, LP, AUDITORS, ADMINISTRATIVE ACTIONS -
Document type: Email

Kinser, Robin D. From: Jill Schultz {jill:schultz@covance.com] Sent: Monday, September 30, 2002 10:17 AM To: Mary Larson; Mary Wesirick; chad.briscoe@mdsps.com; kimberly.prchal@mdsps.com; bettie..nelson@pmusa.com; candace.r.adams@pmusa.com; Hans- Juergen.Rosthig@pmusa.com; Jan.Oey@pmusa.com; mohamadi.sarkar@pmusa.com; robin.d.kinser@pmusa.com; Shixia.Feng@pmusa.com; Valerie.A.King@pmusa.com Subject: Agenda for 09/30/02 Weekly TES Status Meeting A TEXT.htm Performance 093002 Markers.xls Agenda.doc Attached is the agenda and table of site performance markers for today's call. Till Confidentiality Notice: This e-mail transmission may contain confidential or legally privileged information that is intended only for the individual or entity named in the e-mail address. Tf you are not the intended recipient, you are hereby notified that any disclosure, copying, distribution, or reliance upon the contents of this e-mail is strictly prohibited. If you have received this e-mail transmission in error, please reply to the sender, so that we can arrange for proper delivery, and then please delete the message from your inbox, Thank you. CS@VLEL90~
Document type: Report

PME RESEARCH LABORATORY, FEBRUARY 1980 PROJECT TITLE : BIOTECHNOLOGY PERIOD COVERED 2 FEBRUARY lst ~ 29th, 1980 WRITTEN BY : D. SCHULTHESS meme Nitrate electrode (1) An Orion nitrate electrode is currently under test. The company claims that one can measure continuously the nitrate content in liquids. Acid consumption (2) © Trials of the pilot plant showed different results concerning the acid consumption in the NINO~process than those we have found in the laboratory. We therefore determine these values again at different pH-values and initial phosphate concentrations. We could confirm the consumption of 31 g phosphoric acid (35 %) per liter of denitrated extract ata PH of 4.0. This value is independent of the dilution rate. 0,/CO,~Measurement (3) wn Having still some troubles with our CO2/05 determination in the off-gas of fermenters we set up a continuous denitration using a synthetic culture medium. In this trial we could show that we need at least 3 days to reach true steady-state conditions. It however has to be mentioned that the denitration is also ® working without having a true steady-state. We try now to have analogous trials done in the laboratory and pilot plant fermenters Cellulase (4) The production of cellulase by Trichoderma viride DSM 769 was further tested. An addition of glucose at a maximal level of ‘0.2 % increases the yield of this enzyme. The same is true by using Tween 80 in a concentration between 0.1 and 0.5 3%. Freeze-dryer The freeze-dryer has been received and tested. We are able to produce freeze-dryed Ninomass and can now cover the needs of the Richmond flavor department. 4 - 2501124648
Document type: Resume

FF Principal Investigator/Program Director (Last, first, midala): Blanck, George BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed on Form Page 2. Photocopy this page or follow this format for each person. NAME POSITION TITLE George Blanck Associate Professor EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training). DEGREE INSTITUTION AND LOCATION FIELD OF STUDY University of Pennsylvania 1978 Biochemistry Columbia University 1984 Mol. and Cell. Biol. Harvard University (Strominger Lab) 1984-1988 HLA immunogenetics University of Paris (Charron Lab) 1989 HLA immunogenetics RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and honors. Include present membership on any Federal Government public advisory committee. List, in chranological order, the tities, all authors, and complete references to all publications during the past three years and to representative earlier publications pertinent to this application. If the list of publications in the last three years exceeds two pages, select the most pertinent publications. DO NOT EXCEED TWO PAGES. PROFESSIONAL EXPERIENCE 1993- Member, Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida. 1990- Assistant/ Associate (1995- ) Professor, Department of Biochemistry and Molecular Biology, University of South Florida College of Medicine, Tampa, Florida. PUBLICATIONS 2. G. Blanck, S. Chen and R. Pollack, Integration, loss and reacquisition of defective viral DNA in SV40 transformed mouse cell lines. Virology 126, 413-428 (1983). 3. S. Chen, G. Blanck and R. Pollack. Pre-crises mouse cells show strain specific covariation in amount of 54- kilodalton phosphoprotein and susceptibility to transformation by $SV40. Proc. Natl. Acad. Sci. 80, 5670-74 (1983). 4, §. Chen, D. Grass, G. Blanck, N. Hoganson, J. Manley, and R. Pollack. A functional origin of replication is required for the generation of 100K super T-antigen in transformed mouse cells. Virology 48, 492-502 (1983). 5. S. Chen, G. Blanck and R. Pollack. Reacquisition of a functional early region by a mouse transformant containing only defective viral DNA. Mol. Cell. Biol. 4, 666-670 (1983). 6. E, Diann Lewis, S. Chen, A. Kumar, G, Blanck, R. Pollack, and J. Manley. A frameshift mutation affecting the carboxy terminus of SV40 large T-antigen results in a replication and transformation defective virus. Proc. Natl. Acad. Sci., 80, 7065-69 (1983). 7, G, Blanck, S. Chen and R. Pollack. DNAse I sensitivity of integrated SV40 DNA. Mol. Cell. Biol. 4, 559-562 (1984). 9. A. Levitt, S. Chen, G. Blanck and R. Pollack. Two integrated partial repeats of SV40 together code for a super T- antigen. Mol. Cell. Biol. 5, 742-50 (1985). ee PHS 398 (Rev. 5/95) (Form Page 6) Page FF Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3.
Document type: Email

Nixon, Gerry M. From: Sent: To: Subject: auth080201.dec Nixon, Gerry M. Thursday, August 02, 2001 3:16 PM Jachimsky, Hedda; André Badstuber; Anthony Tricker; Bettie Nelson; Bruce Davies; Charles Gaworski; Daniel Hirnikel; Deborah Koller; Edward Carmines; Edward Sanders; Frank Gullotta, George Patskan; Hans-Juergen Roethig; Helmut Reif; Jan Oey; Ken Podraza; Kohji Takada; Lisa Merriman; Matthias Schorp; Michael Werley; Michelle Andriott; Mingda Zhang; Mitchell Ritter; Peter Lipowicz; Raymond Lau; Richard Carchman; Robert Elves; Robin Kinser; Roger Walk; Ruth Dempsey; Valerie King; Willie McKinney Author Search ] | 4 6£9679290z
Document type: Memo

t S Soe me mr oe mes mae ree en mr ee re een eet ee ce et ene eS te ee SS RP Se Se te Sr es we eet ee ee me ee cee mes ee tr er Attached is an updated set of project summaries to be inserted in A. P. Pasheluk S. R. Benson &erilid MEMORANDUM June 25, 1985 _ TRUE BRAND BOOK — your Brand Book. ‘fim Att ccs Ave Capra Daghlian DeLaura Farrell Jones Mau Moroz Smith Staub - Re B. LLb T&868
Document type: Email

2071863841 Chaikin, Karen From: Chaikin, Karen Sent: Monday, November 22, 1999 10:29 AM To: Farlow, Kimberlie J.; Darden, Bennie C. Ce: Sahakian, Marlyne (BURSON) Subject: RE: YSP Model Plant Cmties Conf Calt Kim and Bennie, Can you get updates from your respective colleagues and do a call with me this week or next? Next Friday isn’t good for me, and | know the week of Dec 6 is tight for everyone . [f not, I'll re-issue the activity reports and ask for written updates. Let me know, at which time I'll let everyone know how we will proceed. thanks. KC Youth Smoking Prevention
Document type: Email

Cusato, Denise aint es From: Levy, Carolyn J. Sent: Thursday, August 05, 1999 10:51 AM To: Chaikin, Karen Subject: RE: Focus Groups/debrief | have a conflict--sorry, but | would like to put in my 2 cents before we make changes Carolyn Levy ¥SP 917-663-2253 = Vcec6SV00L02
Document type: Letter

January 5, 2000 Henry L. Chung RJ. Reynolds Tobacco Co. P.O. Box 1487 Winston-Salem, N.C. 27102-1487 USA hdd Imperial Tobacco Limited /Limitée ¥ 3610, roe St-Antoine Street Moentiéal, BQ. HAC iis (514) 932-6161 P.O. Box 6500 CLP. Montréal, BQ. Ha 31.6 ble “Telimp’ < 055-60673 Fax (814) 939-0192 First, we apologize for the delay regarding the text or slides you had requested following the 53rd TSRC held in Montreal. Please find enclosed, a copy of the document on the above mentioned conference. We would like to take the opportunity to wish you and your colleagues all the best for the Year 2000. Best Regards, Jacques Dumont, André Morin Product Research Encl.
Document type: Resume

Name: Curriculum Vitae Alexei J. Likhachev Title/A ffiliation: Chief, Laboratory of Environmental Carcinogenesis N.N. Petrov Research Institute of Oncology St. Petersberg 189646, Russia Birthdate/Birthplace: 1940/Leningrad, USSR Citizenship: Russia Office Address: N.N. Petrov Research Institute of Oncology Department of Carcinogenesis 68 Leningradskaya Street Pesochny - 2 St. Petersburg, 189646, Russia Education: 1966 Ph.D., lst Leningrad Medical Institute Postgraduate Training: 1966 N.N. Petrov Research Institute of Oncology Laboratory of Experimental Tumors Prof. Nikolai P. Napalkov Leningrad, Russia Professional Appointments: 1980-1984 Staff Member International Agency for Research on Cancer Lyon, France Society Memberships: European Cancer Society Editorial Board, Carcinogenesis - 1986-1988 Editorial Board, Experimental Oncology - 1988-present Editorial Board, Problems in Oncology - 1988-present TARC Fellowship Committee - 1986-1990 Publications: 1. Likhachev AJ, Margison GP and Montesano R. Alkylated pruines in the DNA of various rat tissues after administration of 1,2-dimethy] hydrazine. Chemico-Biological Interactions 18: 235-240, 1977. Margison GP, Likhachev AJ and Kolar GF. In vivo alkylation of fetal maternal and normal rat tissue nucleic acids by 3-methyl-1-phenyl triazene. Chemico-Biological Interactions 25: 345-354, 1979. Margison GP, Likhachev AJ and Tomatis L. Incorporation of 5 bromodeoxy uridine into DNA in new born rat tissues. Chemico-Biological Interactions 30: 297-304, 1980. Tomatis L, Cabral RP, Likhachev AJ and Ponomarkov V. Increased cancer incidence in the progeny of male rats exposed to ethylnitroso urea before mating. Int. J. Cancer 28: 475-478, 1981. 50602461
Document type: Memo

PAGE: I PHILIP MORRIS USA ACTIVE RECORDS DISPOSAL NOTICE DATE: 07/01/95 TO: M/C MFG ENGINEERING & MAINTENANCE FROM: RECORDS MANAGEMENT DEPARTMENT THE FOLLOWING RECORDS ARE SCHEDULED FOR DISPOSAL AS OF JULY 1, 1995. RETURN THIS NOTICE TO THE RECORDS MANAGEMENT DEPARTMENT (M/C - EWB) WITHIN 30 DAYS. TOTAL RECORD RETENTION CREATION CATEGORY PERIOD DATE CODE RECORD CATEGORY M+6 12/94 M1512 - MAINTENANCE SCHEDULES I/WE APPROVE THE DISPOSAL OF THE ABOVE RECORDS AND I/WE CERTIFY THE RECORDS APPROVED FOR DISPOSAL HAVE BEEN REVIEWED AGAINST APPENDIX A OF THE PHILIP MORRIS USA RECORDS MANAGEMENT MANUAL AND ANY AND ALL APPLICABLE DISPOSAL SUSPENSION NOTICES AND NONE OF THESE RECORDS ARE SUBJECT TO DISPOSAL SUSPENSION (UNLESS AN EXPLANATION IS ATTACHED OF WHY ANY OF THESE RECORDS SHOULD NOT BE DISPOSED). PA Chew ssring 2019.5 (RECORDS COORDINATOR SIGNATURE) ZL : ° (DEPARTMENT MANAGER SIGNATURE) (DATE) z CERTIFY THE RECORDS APPROVED FOR DISPOSAL HAVE BEEN DISPOSED. OL A SO Wi2pias nn (RECORDS COORDINATOR SIGNATURE) (DATE)
Document type: Resume

i GRANT NUMBER: BIOGRAPHICAL SKETCH Give the following information far the key personnel, consultants, and collaborators listed on page 4. Photocopy this page for each person. BIRTHDATE (Mo., Day, Yr) e NAME POSITION TITLE Ira Jay Goldberg Assistant Professor of Med, 03/11/49 EOU CATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) YEAR INSTITUTION AND LOCATION CONFERRED FIELD OF STUDY Mass. Institute of Technology, Cambridge, MA. Life Sciences Harvard Medical School, Boston, MA. Medicine RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Concluding with present position, tist in chronological order previous employment, ex- berience, and honors. Include present membership on any Federal Government Public Advisory Committee. List, in chronalagical order, the titles and complete references to all publications during the past three years and to representative earlier publications pertinent to this ap- plication. DO NOT EXCEEO TWO PAGES. Professional Experiences Intern, NYU-Bellevue Medical Center, New York, NY, 1975-76, Resident, NYU-Bellevue Medical Center, New York, NY, 1976-78. Fellow, Endocrinology, Mt. Sinai Medical Center, New York, NY, 1978-79. Fellow, Arteriosclerosis & Metabolism, Mt. Sinai Medical Center, New York, NY, 1979-81. Instructor in Medicine, Mt. Sinai School of Medicine, New York, NY, 1981-82. Assistant Professor of Medicine, Columbia University, College of Physicians e@ and Surgeons, New York, NY, 1983-Present. Selected Publications (from a total of 27 original articles) 4, Goldberg, I.J., N.A. Le, J.R. Paterniti, H.N. Ginsberg. F.T. Lindgren and W.V. Brown. Lipoprotein metabolism during acute inhibition of hepatic triglyceride lipase in the cynomolgus monkey. J. Clin. Invest. 70:1184-1193, 1982. 2. Goldberg, I.J., N.A. Le, H.N. Ginsberg, J.R. Paterniti and W.V. Brown. Metabolism of apolipoprotein B in the cynomologus monkey. Am. J. Physiol. 244:£196-£201, 1983. 3. Ginsberg, H., I.J. Goldberg, P. Wang-Iverson, E. Gitler, N.A. Le, H.S. Gilbert and W.V. Brown. Increased non-receptor mediated catabolism of low density lipoprotein apolipoprotein-B in subjects with myeloprolifra- tive disease. Arteriosclerosis 3:233-241, 1983. 4. Goldberg, I.J., R.S. Rosenfeld, I. Pau) and B. Leeman. Generation of plasma free cholesterol from circulating lipoprotein associated cholesteryl ester, Am. J. Physiol. 250: £265-E£268, 1986, I PHS 3382590 (Rey. 9.26) Page ___ NRSA Substitute Page
Document type: Letter

UNIVERSITY of PENNSYLVANIA School of Medicine 2 Department of Biochemistry and Biophysics Philadelphia, PA 19104-6059 Dr. Harmon McAllister Research Director The Council for Tobacco Research - U.S.A, 900 Third Avenue New York, NY 10022 Gctober 2, 1989 Dear Dr. McAllister: I apologize for my belated submission of the preliminary outline for a grant application. Enclosed please find the following: 1. Brief CV and bibliographies (NIH format) 2, Three publications 3. A three page research proposal If I can provide you with any additional information, please don't hesitate to contact me at (215) 898-7671. Sincerely, Lew Ap— bah. Dr. Chiaho Shih Assistant Professor of Biochemistry and Biophysics
Document type: Email

—— Original Message-—-- From: Turner, Henry Sent: Thursday, July 26, 2001 10:07 PM To: Griffin, Leanne Subject: RE: Luxury Suites got the bill and will find the money CILOSTSLS80T
Document type: Memo

PARK 500 ; INTER-OFFICE CORRESPONDENCE CHESTER, VIRGINIA Mr. W. C. Holloman Date. November 7, 1988 J. W. Lusk je | Line III Evaporators ~ Soaking for Cleaning In reference to your question about soaking the evaporators as an alternative means of cleaning, I contacted Sirrine to see if the structural steel was designed to support this type of load. The attached letter from Jeffrey Reeves of Sirrine confirms that the és structural steel will support the flooded weight of all four evaporators. Since Mr. Reeves left open the question on the support lugs for the evaporator, I contacted Chemetron. Mr. Mike Martin of the Engineering ~ Department at Chemetron told me by phone on November 1, 1988, that all evaporators they build are designed to be flooded and the support lugs are designed to handle this type of load. He said that soaking is a common practice with many of their evaporator customers. He cautioned us not to run the main drive on the rotor as this would do damage to the unit. He mentioned that some users do have a "clean out drive" that turns the rotor very, very slowly to help agitate the soaking solution. He also said to not put any extra pressure on the unit while soaking (i.e. keep vent. valves open so pressure cannot build up). My recommendation based on the above is to only soak 1 evaporator at a time and ensure that the’ main rotor drive is locked out prior to filling the evaporator. Pulling the cover plate off the top of the mist eliminator and removing the eliminator screen will provide both a vent opening and an inspection port to allow your operator to see when the evaporator is full of water. With this cover off, you could fill the evaporator with process hot water and crack open the jacket steam just a little (5 PSIG or less) to keep the water hot while the unit is soaking. I understand you have a procedure being written for this operation which I will be reviewing with you prior to using the soaking method for cleaning. If you have any questions, please contact me. cc: A. 0. Hayes J. R. Lawrence F. E. Solesbee J. T. White 2031263025 ~
Document type: Email

-+~Original Message—— From: Ostem, Eric Sent: Wednesday, April 11, 2001 5:53 PM To: Hadel, Linda L. Subject: RE: Next Internet Content Meeting | think we should find out who attends these and what is there agenda---hate to sit in on a meeting unnecessarily--| think you can appreciate that given your 2 weeks here---how would you prefer we handle? Eric Ostern, Manager, Youth Smoking Prevention Programs VOL8LLLS802
Document type: Email

2074179164 Arbetter, Louis From: Sullivan, Rich M. Sent: Thursday, June 10, 1999 2:56 PM To: Quinn, Molly, Turo, Bob Ce: Suter, Mark F.; Owens, Stacey (Madden); Ledebuhr, Paul (Madden); Arbetter, Louis; Sullivan, Rich M: Nickel, Lynn A; Grace, Brian T. Subject: RE: 6' and 8' OPM Conversion As areminder, my recommendation is not to ship OPMs fo retail accounts with a missing panel in the OPM. Our accounts and FSF will be confused and we would have just created total chaos at field level. Additionally, by placing these items on hold we are confronted with potential rejected orders or confusion as we are just beginning the new allocation process. The plan we should be looking at is establishing a clear Game Plan & communications to Madden and HUB agents collectively. Harbor has about 100 message panels in spare parts and plans to ship them to Roselle on Monday (Bulk). Secondly, Bob met with Molly, an prepares a PO for 3,000 + (depending on open orders from Stacey and projected number at TPI ) Message panels for 6’ & 8' OPMs. Hub recaps to Madden the total number of OPMs they have at each TPI depot that needs to be retrofitted. A labor force is hired and is sent to Roselle to open aif 6' & 8' opms and remove the clocks and make one good OPM from 2 OPMs (marking each completed OPM with a retrofitted sticker). Additional panels would be shipped from Roselle to TP! depots to have agents retrofit them PRIOR to the day they are to be installed. {Documentation outline to follow) Once the production of the Panels are completed from Harbor they are shipped to Roselle and the remaining OPMs are made whole using the hired labor force again. | know this is not the complete process flow, but does present a solution with out upsetting our current process. Rich
Document type: Memo

PHILIP MORRIS U.S.A. » INTER-OFFICE CORRESPONDENCE RICHMOND, VIRGINIA To: *« PM USA Records Coordinators Date: February 23, 1994 From: e Lewis Cummings Subject: * NOTICE OF DISPOSAL SUSPENSION The attached Notice of Disposal Suspension lists certain records in addition to those listed in Appendix A of the PM USA Records Management Manual which ~* are suspended from disposal. This Notice of Disposal Suspension should be placed in your Records Management Manual and should be reviewed in addition to Appendix A prior to approving the disposal of any records. I will notify you upon the release of any of these records from the disposal suspension. If you have questions, please let me know. @ Attachment c: M. Z. DeBardeleben W. G. Insley Ww. Lynch, III J. L. Miller Cc. Cc. Purcell E. W. Reese K. W. VandenBroek J. R. Ward FILE: POS8l1 GOZOSITSOZ
Document type: Letter

GRAY AND COMPANY JOHN BERARD VICE PRESIDENT October 4, 1984 Mr. William D. Toohey, Jr. The Tobacco Institute 1875 I Street, NW Washington, D.C. 20006 Dear Bill: The perspective (and follow-up) afforded by a week seems sufficient for reporting, though not finally, on the results of our effort last Tuesday at the National Press Club and the announcement of "Helping Youth Decide." The event was, as you know, preceded by a week-long period of =;, “background briefings” with key media. The coverage based upone;. — these briefings, the event itself and follow-up fall into two ?h broad categories. These are Print and Electronic. = On the print side, we have verified the following: The Lowell (Massachusetts) Sun ran the story. Copy to come. The reporter was Tom Squitieri. Gannett News Service -- serving 86 newspapers in 37 states -- ran the piece. The reporter was Pat Ordovensky. Scripps-Howard -~ serving over 60 newspapers out of the Washington bureau -- filed the story. Ken Eskey is the reporter. A copy of this one has already been forwarded to your attention. USA Today ran with the story on the day of the event. As you know from my backtracking, the eventual three-line item which appeared in the National News section that day was culled from a larger, more comprehensive piece done for the Life section by reporter Barbara Zigli. The piece was deemed more national than lifestyle news by the Life section editors and it was shipped to National where it was snipped by Julia Wallace who is a national news editor. No follow-up by USA Today is planned, although Life editor Linda Kauss wants to see updates on program acceptance, usage, etc. (more) TINY 0011257 PUBLIC COMMUNICATIONS INTERNATIONAL THE POWER HOUSE WASHINGTON, D.C. 20007-3644 TLX: 440143 GRAY Ul 202-333-7400 TWX: 710-822-9282 GRAY CO WSH
Document type: Memo

Ge ~~ «e PHILIP MORRIS U.S.A. | INTER-OFFICE CORRESPONDENCE 120 PARK AVENUE, NEW YORK, NY 10017 TO: Field Sales Force DATE: July 31, 1996 FROM: Rich Lamanno/Sales Promotions SUBJECT: Cambridge August FSI As an incentive to smokers, an FSI featuring a coupon for $1.50 off Cambridge will appear in your market on August 25, 1996. Enclosed is a sample of the FSI and the markets in which it will appear. You may want to notify your retailers of this upcoming offer and take this opportunity to address distribution, low stock, or out-of-stock situations. Please contact your Region Trade Marketing Promotions Manager if you have any questions or comments. co" W. ller E. Schauer LECOTe290Z2 HARD COPIES PROVIDED BY NYO TO SELECT VPRSs, TMDs, SSDs, TMPs, TMMs, TMFs, NAMs, RFDs, HRDs, RMIAs, SOMs, DMs, SAMs, UMs, RFAs, TSMs, DSMs, SDAs, AND RTs in PARTICIPATING MARKETS. DOC. #395
Document type: Report

From: The Second Surgical Clinic of the University of Vienna Director: Professor Dr. W, Denk, Beitrage zur Klinischen chirurgie, Munich, 186:259-384, Nove 3, 1953. REMARKS ON BRONCHIAL CARCINOMA by W, Denk ‘ During the last years there have been many papers on lung cancer, It is therefore, unnecessary to review here consequently this very timely disease, In the following, we shall discuss a few aspects of the total problem and report a few observations which we have been able to make with the many patients of our Clinic. There seems to be no question that the absolute number of bronchial carcinomata has increased, This can be further proved by a few figures, : Gesell reports from Switzerland that the totel mortality from cancer has almost doubled (1.8:1) from 1904 to 1948, while the mortality from lung cancer has ine creased in the same period 20,7 times, In the United States in 1920, 1,1% of all deaths due to cancer were due to a bronchial carcinoma, while in 1948 the figure was already 8.3%, The figures for the population of the city of Vienna have been put at our dis- posal by the Central Statistical Office of the city, Total deaths due to cancer have increased from 1931 to 1938 (21 city districts) 15.3%, and from 1939 to 1951 (26 city districts), they have increased by 16.7%, The deaths from carcinoma of the respiratory system in men were 15.8% of all cancer deaths in 1931, 20.6% in 1938, and 31.76% in 1951, For men and women together, the percentage of deaths from cancer of the reapira- tory system as a percentage of the total mortality from cancer was 6.66% in 1931, 11.92% in 1938, and 17,94 in 1951, The total mortality of the population of the City of Vienna due to cancer has increased by one sixth during the last twenty years; the mortality from cancer of the respiratory system has doubled, In 1934, 440 people died per each 100,000 inhabitants of the City of Vienna due to cancer of the respiratory system; for 1939, the figure wis 584, and for. 1951, 1,014, These figures likewise prove that there was a mch greater increase in deaths due to lung cancer when referred to the total mortality due t. cancer. These conclusions, however, are somewhat limited by the fact that the mortality statistics do not give’as clear a picture as a morbidity statistic, which does not exist in Austria, It is certain that presently a greater number of other carcinomata than those of the lung are cured, and those naturally are not in- cluded in a mortality statistic for cancer. This arguement against the mortality statistics nevertheless, does not alter the fact of the absolute increase. How- ever, we shall not discuss these theories in detail, Here we shall discuss only the effects of cigarette smoking on bronchial carcinoma, since these relations are a great timeliness. We shall discuss this on the basis of patients in our Clinic, : LOLI 9BLOS
Document type: Email

-----Original Message----- From: Balgley, Annemarie Sent: Wednesday, September 13, 2000 2:24 PM To: Walsh, Molly Subject: RE: FW: Urban League Budget Thanks, did you find out which one is going to the Texas Wildlife Expo? Annemarie Baigley Youth Smoking Prevention O8egZPrg9esoe
Document type: Memo

INTER-OFFICE MEMORANDUM oto oz hes 2 & e '" April 3, 1986 Dr. G. R. Di Marco TO: SUBJECT: Weekly Highlights Process Technology & Development I. ADVANCED PROCESS TECHNOLOGY e Extraction Investigation The extraction/spray drying process line in 112 Shed is operational. Equipment characterization is in progress and minor modifications are being made as necessary. Several extended runs, 24 hours or more, are planned in order to achieve equilibrium operation and develop com- plete mass balance data. Spray dried extracts are being evaluated in products. The extracted tobacco is also being studied to determine its potential uses. Sa If. PROCESS DEVELOPMENT G-7 Pilot Line Qualification G-7 product has been prepared via the G-7 Pilot Line and will be evaluated against G-7 plant prod- uct to establish base line parity. Brand R&D and PT&D have finalized plans for separate extraction .G-7 prod- ucts which will be prepared during April. The plans consist of 12 products to determine the influences of stem, scrap, flue-cured and burley extract. Primary Processing Specifications The strategy for obtaining target and control limits has been developed. Brand R&D will determine the initial reject limits for casing, G-13, and top flavor application. 6545 79505
Document type: Email

From: Hennes, Bruce To: Cole, Ron W.; deButts, C. Read; Ellis, Jim; Goodyear, Douglas; Hensley, Robert W.; Hyde, Timothy N.; Marshall, M. Hurst; Phillips, Mike W.; Wold, Kent L.; Johnson, Emilie; Klein, Cheryl; Klein, Walt; Nelson, J. Byron CC: Ruffin, Ben S. BCC: Primary Date: 10/25/1995 9:46:00 AM Last Modified Date: 2001-Nov-20 11:21:46 Last Touched Date: Sent Date: 1995-Oct-25 09:28:00 Received Date: 1995-Oct-25 09:46:00 Subject: Hennes’ Weekly Report Attachments: BRUW1025.D0C A VERY brief weekly report to y'all this week...... RJRO000000507203058 70020 2608 1998 beezs
Document type: Report

The essential details in the article on tlhe Isolation of ce rednowents Mtterial from Cigarette Tar" by C. Seelkopf,( Z. LERENSM, UNTERSUCHUNG FORSCHUNG, 100(3), 218-222(1955)) are as follows: a) (44) (144) (iv) (v) (vi) (v}i) ‘The smoking apparatus employed was essentially stendardy the puff rete wes 2.5 seo; ,puff every 2245 seo, or a 2 puff followed by a 20 sec. Japse. The vemperatures observed during the stoking phoeosa-nIbit of. 68000)" high of 800%, average of 742%--are in agreement with temperature reported previously by Wy nder, Graham and Cr oningsr (CANCER RESEAROH 13, 855(1953)) and by Cooper, i ndsey and Waller (BRIT. MDs Nov. 18, 1964; CHEM. & IND., 2954, 1418). The quantity of tar obteined represented 5-t0 10% of the’ Weight’ or. a standard ] gm. cigarette. According to k¥XK Schmahl, Co nsbruch >. ° end Druckrey (ARZNEIMITWEI-FORSCH., 4, 71(1984)) 98% of: the ‘ter inhaled is absoebed by the smoker. Seolkopf onioulates that: d “‘shoking 30 ciparettes per dey for 20 years would absorb “from a 365,x £0 x 10 x 0.05 x 0.9&/3000 to “365 x 20 x 10 x 0.10 x 0. pee or 3.6 to 7. 2 kem. ter.in 20 years. The tar was fractionatdd into acidic, basic end neutral freotiones, wa The neutral fraction represented 37, be of the total tar, bistillation of this neutral fraction at reduced pressure gave.” 10 fractions boiligg from 70%/ 3 mm. to 290U/5 mm. and age a -residue of 9.8 of the Lotel. Weight. of the “ter. . Chromatographic analysis of these verious frections indieated. the | presence of naphthalene (noncarcinogenic), anthracene (noncarcdno- _ . genic) and $,4-benzpyrene (carcinogenic). : “ad The author estimates that 100 em. of cigarette tar contains 50 gene (estimated spectrophotometrically) of 3,4-benzpyrene. Cooper, lindsey and Waller (see above reference) estimate that & person smoking 40 cigarettes per day would absorb 150 gamma of 3,4-benzpyrene per year Whereas a calculation using Secikopf'ts date indjostes thet a person smoking 10 cigarettes per day would absorb S65 x 10 x 0.05 x 0.98 x 0/100 Lo ‘3.85 x 10 x 0.10 x 0:98 -x 50/100 or 90 to 180 gamma of 3 ,4-benzpyrene per year. Jt is interesting to note that the investigators (Cooper et al, soe” above; Seelkopf, this article; and vynder and wright, PROC. AM. ASSOC. | CANCER RESEARCH, ABSTRACTS, 46th sANN. whEVING, apr. 15-7(1 955), : 2(1), 65(1955)) who have employed a 2 t0 £,5 sec. puff every 20 sec, — or so have reported the presence of 5,4-benzpyrese whereas the invest-- igators (Kosak et al, Data presented at the sii, CHEM. SOC, Meeting, Cincinnati, Chio, March 29, 1955) who employed a 2 sec. puff Overy fonts 6Onseec. have not "ye ported any 3,4-benzpyrene in the tar. : CHEE FZEOS
Document type: Email

From: Byron Nelson To: Brinkley, Carolyn G.; Cole, Ron W.; Cook, Bruce A.; Cruz, Cynthia; Ellis, Jim W.; Goodyear, Douglas; Holland, Toussaint L., Hyde, Timothy N.; Loeser, Gary; Lowstetter, Jean S.; Marshall, M. Hurst; Mozingo, Roger L.; Murray, Joe S.; Phillips, Mike W.; Powers, David M.; Shore, Pat J.; Singleton, John W.; Smith, Mark D.; Speas, Vickic L.; Stokes, Henry S.; Suggs, Michael L.; Tompson, Randy; Walker, T. Nathaniel; Williams, Richard L.; Wold, Kent L.; 'Doug Anderson’; 'Michac] Cockman’; 'Read DeButts’; ‘Mike Harrell’; ‘Cheryl Klein’; ‘Walt Klein’; ‘Kim Logue’; 'Eric Lundgren’; 'Kar] Maher’; ‘John Morrow’; ‘Greg Osmon’; ‘LINDA PFAFF<PFAFFZL>’; ‘Matt Tilley’ CC: Gallagher, Elizabeth BCC: Primary Date: 7/30/1996 3:27:44 PM Last Modified Date: 2001-Nov-20 02:20:59 Last Touched Date: Sent Date: 1996-Jul-30 14:22:32 Received Date: 1996-Jul-30 15:27:44 Subject: Time: 3:40 PM Morning Team Notes 7/26 Date: 7/30/96 Cattaraugus County, NY--At recent public hearing, county legislators heard five retailers speak out against the self-service display ban proposal and only one citizen speak for it. The legislators decided to re-refer the bill to committee because they said it was too broad the way it was written. They won't bring it back until after Labor Day at the very earliest. Over in Chautauqua County, the legislators will consider exempting cigars and making a "3-foot from the register" exception for smokeless when an amendment is heard in the next month. This could give cigarette retailers an opportunity to go back in an maybe at least get some space on the the counter--not just behind it. The local Rite-Aid drug chain, with five stores in the county, is mainly pushing for the cigar, smokeless exception. | - RJR0000000507107257 | 70017 8131 O06r Loses
Document type: Memo

Dorillord MEMORANDUM November 1, 1984 TO: E. M. Kiernan FROM: J. B. Asher SUBJECT: MARKETING RESEARCH BUDGET (KENT FAMILY-MRD #5541) Following is a detailed analysis of as of September 30, 1984. Total 1984 Budget 5541/184 541/284 5541/384 5541/484 5541/584 5541/684 5541/984 5541/884 Study Kent, Family Portfolio Test West. Coast AAU Travel Promotion Qualitative Product Reformulation Corporate AAU - Travel Promotion Portfolio Test Conversion Study ($1 off/ carton-Milwaukee) Kent III Portfolio Test Total Committed/Actual Budget Balance* *TTL Less! Committed If you have any questions, please call. Burke . Farrell .- Jones Lamb - Moroz Staub QHmnhrAvSs Additional Questions $325,000.00 Amount Committed 49,500.00 25,500.00 21,000.00 103,800.00 4,500.00 20,800.00 11,000.00 11,600.00 247,700.00 $77,300.00 the: 1984 Kent Family budget Actual 49,000.00 25,500.00 12,046.00 69,200.00 13,900.00 169,646. 010 TPSs ¥928
Document type: Email

From:Reesc, Bonnic L. To:Bratton, Deborah B.; Montgomery, Nancy W. CC: BCC: Primary Date: 1/10/1997 12:24:01 PM Last Modified Date: 1997-Dec-29 09:32:54 Last Touched Date: Sent Date: 1997-Jan-10 12:24:00 Received Date: 1997-Jan-10 12:24:01 Subject: Mail Kits for Personal Selling in FL{F} Attachments: SSSA NENA RANA NENA NEAR AABN NEES HTSUS SD SDSS EET SE THN HSE STEERED Heard from Todd; this is in the works, he is currently working on it. Same as last year, two coupons. I'm still trying to get an answer from Camel. From: Reese, Bonnic L. To: Holbrook, Todd M.; Snyder, Lindsay D. Ce: Montgomery, Nancy W.; Bratton, Deborah B. Subject: Mail Kits for Personal Selling in FL Date: Friday, January 10, 1997 8:24AM Todd, do you know if any planning has taken place on the 97 mail kits for the two races in Florida where we will be doing personal selling? Last year the Winston Kit was a letter about the race, and two coupons. Both expired 12/31/96 - one was for $3 off 4 packs or 1 carton, and the other was a B1GIF. Lindsay's group provided a paragraph about the race to Brenda Granderson in Consumer Relations and she incorporated the paragraph into a letter. The letter was actually run on legal-size paper, with the two coupons as tear-offs on the bottom of the letter. I have a sample of the paper, coupons, and cnyclope uscd. Included with the letter was a survey about future purchase intent. Do you know who is in charge of planning for the mail kit this year? New coupons will have to be printed, and the survey may need to be revised. Pls let me know. Thanks. gZg¢ 6220S RJR1667071016 70000 7419
Document type: Email

Moore, Mary Ellen From: Colby, Dolly Sent: Thursday, January 29, 1998 7:21 PM To: Brenda Fleming; Colleen Keenan; Darienne Dennis; Heather Erskine; Jack Macauley; Jennifer Zadikow: Johan Puotila; John Galletta; John Sorrells; Karen Wallace; Kenneth Seda; Mary Ellen yee Patches Magarro; Peggy Roberts; Richmond Temple; Stephanie Davenport Davenport; ic Han Cc: Woodward, Ellis; Maher, Jayne; Parrish, Steve; Carnovale, Mary (PMUSA Mac Mail); Carraro, Tara (PMUSA Mac Mail); Daragan, Karen (PMUSA Mac Mail); Dawson, Nicole (PMUSA Mac Mail); McCormick, Brendan (PMUSA Mac Mail); Quast, David (PMUSA Mac Mail), Storan, Susan (PMUSA Mac Mail); Szumera, Michael (PMUSA Mac Mail); Tapie, Monique (PMUSA Mac Mail) Subject: AT/Public Radio Importance: — High Marge Kaplan of Public Radio called earlier, (617-492-2777 x2315) She wanted to know when the 30 million pages of documents that GCB talked about would be released, AT Referred to Sawyer Miller. d00r6sec40c
Document type: Letter

we ; October 23, 1961 Br. Ernest Sondheimer Associate Professor of Plant Biochemistry State University College of Forestry Syracuse University Syracuge 10, Hew York Dear Doctor Sondheimer: Iu reply to your letter of Oetober 10, 1961, we are glad to send you a set of the forme which we use for filing applications for grants«in-ald. You are probably aware that all mathers of research policy and all recommendations for grants are the responsibility of our Scientific Advisory Board, The names of its members are shawn in the enclosed copy of our last Aunual Report, The enclosed pamphlets will give some indication of the sub« jects which fall.within the general area of their interest. Whether support ean be furnished al, the present time will, depend upon relative priorities of interest as determined by the present status of the program and in relation to the budgetary situation. The best course will be to outline a proposal on the enclosed forms. The original is interded for this office and the carbon for your own files. Please note that the signature of an officer of administration is requested if a ' the work is to be carried out in a university, hospital or other Inatitution. Gur Board meets at approximately quarterly intervals. Applications are circulated to study groups or subcommittees for advance consideration and then are Listed on the agenda of the next meeting of the Board, following com- pletion of comaittee work, Sometimes a site visit is considered advisable in preparation of recommendations, We could expect an application which reaches us by November 1, 1961 to be poet on the agenda of the meeting which has been scheduled for Decexiber Buh, i9 ee We will be very glad to bring any proposal you wish to submit prompt- iy to the attention of the subconimittees and the Board. Sincerely yours > tek, rhisl Gh [ecelecer moles C. Hockett, Ph.D. Assoetate Sclentifie Director A RCH: tih eucle. (+) Annual — 2 pamphlets » application blanks P. S. Overhead is ordinarily allowed up to 15% of the budget total exclus+ ive of appropriations for expensive itema of a a og equipment. BR » He , onmet BE Sma RE Cet RT Sea ated fe Se Bg Oe PRO Pee ee oe ot FEE ee AE BE
Document type: Report

C. in) Fortified Smoke Studies Cigarette Fortificetion Equipment Capacity One Machine: 10 cigarettes/run x 7 runs/day x 7 day/wk = 490 cig. Four Machines: 490 cig/machine/7 day wk x 4 machines = 1960 maxium Anticipated usable cigarettes = 1800/wk Toxicity studies Scheduled for January In the Toxicity studies mice will be smoked with for- tified smoke for a period of 4 weeks, 10 cig/day, 10 mg/cig. At the end of the 4 week period we proposed to stop smoking and hold the mice for tumor occurrence at the time of mor- bidity. We propose to use the mice now adapted to smoke which have had Sendai infections. After they have been smoked with MCA or BaP or Benzene treated cigarettes, they will be moved from 4807 Laboratory to 4809 Laboratory for observation. This will allow 4807 to be decontaminated and new mice to be brought into the facility. MCA, 10 mg/cig, four - 7 day weeks. 60 mice/(12 mice/machine run) = 5 machine runs/day. 5 machine runs x 10 cig = 50 cig/day. 50 cig/day x 28 days = 1400 cig. . 1400 cig x 10 mg MCA/cig = 14 gm MCA. 1400 cig/(450 cig/one loading machine) = 3.1 -wks. 1400 cig/(1800 cig/4 machines) = 0.77 wks. BaP ~ same as MCA 1400 cig, 14 gm BaP, 0.77 wks to load on 4 Machines. Benzene treated cig. 1400 cig, 0.77 wks to load on 4 machines or 3.1 wks on oné machine, MCA Series of Fortified Smoke Studies Two Studies are proposed with MCA: We will combine [001A and B to determine if short term MCA exposure followed by long term Standard Smoke will induce tumors. This would aliow more fortified smoke studies to be undertaken by first exposing to fortified smoke on the Walton and then transfering to the SEM for long term smoking which may act as a promoter. The fol- lowing studies have not included a very important group of controls. We have not included mice which will re- ceive the MCA in smoke and then allowed to live without smoking. The inclusion of these mice required the re- thinking of the entire schedule, equipment capacity, personnel, etc. in most studies. We could include one such group with {001A and B, but not both the 3.25 and 7.0 week exposure period, I! want to suggest that we run one more group for 7 weeks on fortified smoke and no futher smoking. CTR CONTRACTS 019294