Document type: Resume

FF PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR: 1, ° BIOGRAPHICAL SKETCH Give the following information for the key personnel and consultants listed on page 2. Begin with the Principal Investigator/Program Director. Photocopy this page for each person. - gueira, Christine P. NAME POSITION TITLE BIRTHDATE (Mo., Day, Yr.) DOUGLAS V. FALLER Professor 08/18/52 EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) INSTITUTION AND LOCATION DEGREE YEAR FIELD OF Stupy Massachusetts Institute of Technology B.S. 1973 Biochemistry Harvard Medical School M.D. 1979 Medicine Massachusetts Institute of Technology Ph.D 1978 Cell Biology M.I.T. Center for Cancer Research Post.Doc. 1979 Virology RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and honors. Include present membership on any Federal Government public advisory committee. List, in chrenological order, the titles and complete references to all publications during the past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. HOSPITAL APPOINTMENTS: 1979-1981 Resident in Internal Medicine, University of California, San Francisco, CA 1981-1982 Fellow of American Cancer Society, Brigham and Women's Hospital, Boston, MA 1981-1983 Fellow in Medicine, Hematology/Oncology, Children’s Hospital, and Dana-Farber Cancer Institute, Boston, MA 1981-1983 Research Fellow, Harvard Medical School ACADEMIC APPOINTMENTS: 1983-1984 Instructor, Harvard Medical School, Boston, MA 1983- Associate in Medicine, (Hematology/Oncology) Children’s Hospital 1985- Associate Physician, Dana-Farber Cancer Institute 1984-1987 Assistant Professor, Harvard Medical School, Boston, MA 1984-1987 Associate Professor, Harvard Medical School, Boston, MA 1991- Professor of Medicine, Biochemistry, Pediatrics, Microbiology, Pathology and Laboratory Medicine Boston University School of Medicine 1991- Director of Cancer Research: Center, Boston University Schoo! of Medicine 1991- Vice-Chairman, Division of Medicine, Boston University School of Medicine Awards and Honors: 1973, Phi Beta Kappa (Massachusetts Institute of Technology); 1973, Phi Lambda Upsilon; 1979, M.D. granted with honors; 1981, American Cancer Society Fellow; 1983, Boston Blood Club Young Investigator Award; 1983, American Cancer Society Faculty Award; 1983, John and George Hartford Foundation Feliowship; 1983, Anna Fuller Award; 1987, American Cancer Society Senior Faculty Award MEMBERSHIPS, OFFICES AND COMMITTEE ASSIGNMENTS IN PROFESSIONAL SOCIETIES (Selected) 1975- American Society for Microbiology; 1981- American College of Physicians, Member; 1983-1989, NIH Study Section; 1985- American Society for Hematology; 1985- Harvard Committee on Virology; 1988- American Association for Cancer Research; 1988- American Federation for Clinical Research; 1989- American Society for Clinical Investigation; 1991- Director, The Medical Foundation; 1991- Board of Directors, American Cancer Society; PusBucaTions (Selected from 139) 23. Flyer, D.C., Burakoff, S.J. and Faller, D.V.: Cytotoxic T lymphocyte recognition of transfected cells expressing a cloned retroviral antigen. Nature, 1983, 305:315-318. 28. Flyer, D.C., Burakoff, S.J. and Faller, D.V.: Retrovirus-induced changes in MHC antigen expression influence susceptibility to lysis by cytotoxic T lymphocytes. Journal of Immunology. 1985, 135:2287-2292. 37. Lichtman, A.H., Reynolds, D.H., Faller, D.V. and Abbas, A.K.: Immortalization of mature, hapten-specific murine B cells by Kirsten sarcoma virus. 1986, Nature, 324:489-491. 39. Flyer, D.C., Burakoff, S.J.and Faller, D.V.: The immune response to Moloney murine leukemia virus induced tumors: Induction of CTL specific for tumor-associated antigens. 1986, J. Immunol. 137:3968-3971. 49. Lichtman, A.H., Williams, M.E., Paul, W.E., Faller, D.V. and Abbas, A.K.: Retrovirus infection alters growth factor responses in T lymphocytes. 1987, Journal of Immunology, 138:3276-3284. 52. Wilson, L.D., Flyer, D.C. and Faller, D.V.: Murine retroviruses control class | Major Histocompatibility Antigen gene expression via a trans effect at the transcriptional level. 1987, Molecular and Cellular Biology, 7:2406-2415. 55. Faller, D.V., Kourembanas, S., Ginsberg, D., Hannan, R., Collins, T.: Immortalization of human endothelial cells by murine sarcoma viruses, without morphologic transformation. 1988, J. of Cell Physiology, 134:47-56.