Document type: Report

DRAF'?-DRAFT-DRAFT—-DRAFT-DRAFT-DRAFT-DRAFT—-DRAFT—DRAFT—-DRAFT—-DRAFT HIGHLIGHTS DATE: April 24, 1990 BIOBEHAVIORAL RESEARCH “3 Psychophysiology of Smoking - Integration of analytical chemistry data with EEG, heart rate, task-performance, and mood/feeling rating data from the 1989 EEG study was begun. Subjects were segregated into 3 groups based on pre- to post-smoking plasma nicotine ‘rise’. Appropriate analyses of Variance are underway. Drs. Reynolds, Robinson, and Pritchard met discuss a study to determine the optimal structure for DFC (Desire For Cigarette) measurement. Ina subsequent meeting, Drs. Robinson and Pritchard planned the detailed experimental design. Basic Sensory Research - Evoked brain potentials, respiration, and sensory data were collected from one subject during exposure to nicotine. This session completed collection of required evoked potential data for 6 subjects. Collection of data from subject 5, an in-house volunteer, is all that remains for the completion of this phase of the work. Mr. Roger Jennings prepared computer files of sensory attribute data on ETS chemicals from recently published reports. Sensory information on chemicals in ETS will be incorporated into a relational database that contains other information on the compounds. The data base will be used to answer end-user questions on specific chemicals or sensory characteristics. UNIFY database software, currently on the Biobehavioral Division’s SUN computer, was evaluated by Mr. Jennings for use with the ETS data. Dr. Jim Walker attended the 12th annual meeting of the Association of Chemoreception Sciences. He presented a paper entitled "Effects of Odorants on Respiratory Behavior and Nasal Patency." It was timely, owing to a great deal of interest by meeting participants in the question of perceived irritation in humans. The following were noted at the meeting: an increase in research on primate gustatory and olfactory systems, renewed interest in "taste" sensations mediated by the olfactory system, increased representation of manufacturers of fragrances and others who use fragrances to enhance product appeal, increased competition among NIH-funded chemosensory centers, increased interest in the "olfactory deficit" in Alzheimer’ Ss disease, sophisticated use of voltage-sensitive dyes and video- imaging techniques, interest in the measurement of human respiratory behavior, an increase in the number of industrial chemosensory scientists conducting psychophysical studies, an increase in the number of chemosensory scientists in consumer product R&D, and increased interest in odorant-evoked potentials. Smoke Component Dose - Mr. Davis sought information from Dr. Brian Lawrence and Mr. Brian Smeeton (P&AT) about tea cultivation and the use of nicotine sulfate as a pesticide. Mr. Davis is preparing to survey a number of teas for potential nicotine content. We and others have observed nicotine in teas previously. Nicotine Receptor Pharmacology - Dr. Eric Fluhler continued to characterize the effects of nicotine on calcium flux in synaptosomes prepared from adult ~~ rat brain. Results indicate that micromolar concentrations of nicotine Significantly increase intrasynaptosomal concentrations of calcium. Modulation of calcium levels is thought to help regulate the release of neurotransmitters from nerve terminals in vivo. The abilities of several T8OG 66L0g