Document type: Resume

PERSONAL BIBLIOGRAPHIC SKETCHES MICHEL CHRETIEN_ (Co-Investigator) - Effort on this project: 10% EDUCATION: Institution Degree Year Field of Study University of Montreal, Montreal M.D. 1960 Medicine McGill University, Montreal M.S. 1962 Experimental Medicine Hétel-Dieu de Montreal Hospital Fellow 1960-62 Clinical Research McGill University, Montreal Fellow 1960-62 Experimental Medicine Peter Bent Brigham Hosp. & Harvard University Resident 1962-64 Medicine University of California, Berkeley Research Fellow 1964-67 Biochemistry ACADEMIC POSITIONS: Professor, Dept. of Medicine, Univ. of Montreal, 1967- Director, Dept. of Molecular Neuroendocrinology, Clinical Research Institute of Montreal, 1967- Physician, Hétel-Dieu de Montreal Hospital, Montreal, 1967- Associate Member, Dept. of Experimental Medicine, McGill University, 1967- Scientific Director & CEO, Clinical Research Institute of Montreal, 1984-94 HONOURS & MEMBERSHIP: Order of Canada (OC) Officer, Ordre du Quebec Fellow of The Royal Society of Canada (FRSC) Fellow of the American College of Physicians (FACP) Fellow of the Royal College of Physicians and Surgeons of Canada (FRCP) Izaak Walton Killam Memorial Price, 1995 McLaughlin Medal, Royal Society of Canada, 1993 D.Sc. (Honoris Causa), Universite Rene Descartes, Paris, France, 1992 D.Sc. (Honoris Causa), Universite de Liege, Belgique, 1980 PUBLICATIONS: TOTAL; 471; Last 5 years: 1992-96: Referred Papers: 66, Book Chapters: 9 Selected Relevant publications for the past 5 years: Benjannet S, T Reudelhuber, C Mercure, N Rondeau, M Chrétien, and NG Seidah (1992) Pro-protein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity and intracellular environment. J.Biol.Chem. 267:11417-11423. Copeland NG, DJ Gilbert, M Chrétien, NG Seidah, and NA Jenkin (1992) Regional localization of three convertases PCI (Nec-1), PC2 (Nec-2), and Furin (Fur), on mouse chromosomes. Genomics 13:1356-1358. Day R, MK-H Schafer, SJ Watson, M Chrétien, and NG Seidah (1992) Distribution and regulation of the prohormone convertases PC] and PC2 in the rat pituitary. Mol.Endocrinol. 6:485-497. Seidah NG, J Hamelin, AM Gaspar, R Day, and M Chrétien (1992) The cDNA sequence of the human pro-prohormone and pro-protein convertase PCI. DNA Cell Biol. 11:283-289. Seidah NG and M Chrétien (1992) Pro-protein and pro-hormone convertases of the subtilisin family - recent developments and future perspectives. Trends Endocrinol.Metab. 31:133-140. Seidah NG, H Fournier, G Boileau, S Benjannet, N Rondeau, and M Chrétien (1992) The cDNA structure of the porcine pro-hormone convertase PC2 and the comparative processing by PCI and PC2 of the N-terminal glycopeptide segment of porcine POMC. FEBS Lett. 310:235-239. Seidah NG, R Day, J Hamelin, A Gaspar, MW Collard, and M Chrétien (1992) Testicular expression of PC4 in the rat: molecular diversity af a novel germ cell-specific Kex2/subtilisin-like proprotein convertase. Mol.Endocrinol. 6:1559-1570. Watson SJ, WE Cullinan, MK-H Schafer, R Day, M Chrétien, and NG Seidah (1992) Anatomical studies of neuropeptide precursor processing enzymes. Clin.Neuropharmacol. 15:315-316. Benjannet S, N Rondeau, L Paquet, A Boudreault, C Lazure, M Chrétien, and NG Seidah (1993) Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PCI and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PCI and PC2. Biochem.J. 294:735-743. Day R, MK-H Schafer, WE Cullinan, SJ Watson, M Chrétien, and NG Seidah (1993) Region specific expression of furin mRNA in the rat brain. Neurosci.Lett. 149:27-33. Jean F, A Basak, N Rondeau, S Benjannet, GN Hendy, NG Seidah, M Chrétien, and C Lazure (1993) Enzymic characterization of murine and prohormone convertase-I (mPC1 and hPC1) expressed in mammalian GH,C, cells. Biochem.J. 292:891-900. 1-2 ~~ 50557910