Document type: Resume

DUPLICATE co® - USE IF NEEDED FR 7 PRINCIPAL INESTIGATORPROGRAM DIRECTOR: BIOGRAPHICAL SKETCH Give the following information for the key personnel and consultants listed on page 2. Begin with the Principal Investigator/Program Director. Photocopy this page for each person. NAME ~ |posmion TITLE ~ TBIRTHDATE (Mo, Day, Yr) _ Veronique Kruys, Ph.D, | Associate 9/16/63 EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training) YEAR 7 INSTITUTION AND LOCATION DEGREE CONFERRED FIELD OF STUDY Free Univeristy of Brussels B.A. 1985 Chemistry Free University of Brussels Ph.D. 1989 Chemistry RESEARCH AND PROFESSIONAL EXPERIENCE: Concluding with present position, list, in chronological order, previous employment, experience, and honors. include present membership on any Federal Government public advisory committee. List, in chronological order, the titles and com- plete references to all publications during the past three years and to representative earlier publications pertinent to this application. DO NOT EXCEEO TWO PAGES. October 1985 to October 1987, employed by the Institute of the Encouragment for Scientific Research In Industry and Agriculture (Brussels). October 1987 to February 1990, employed by the Free University of Brussels as Research Assoclate with teaching activity in undergraduate programm (Brussels). February 1990 - Present, employed by the Howard Hughes Medical Institute at Dallas as Research Associate. PUBLICATIONS (Partial List) Kruys, V., Wathelet, M., Poupart, P., Contreras, R., Fiers, W., Content, J.. and Huez, G. (1987). The 3’ untranslated region of the human interferon-8 mRNA has an inhibitory effect on translation. Proc. Natl. Acad. Sei. U.S.A. 84, 6030-6035. Poupart, P., Vandenabeele, P., Cayphas, S., Van Snick, J., Haegeman, G., Kruys, V., Fliers, W., and Content, J. (1987). B-cell growth mobulating and differentlating activity of recombinant human 26 kDa protein. EMBO J. 6, 1219-1224. Kruys, V., Wathelet, M., and Huez, G. (1988). Identification of a translation inhibitory element (TIE) in the 3’ untranslated reglon of the human interferon-8 mRNA. Gene 72, 191-200. Kruys, V., Marinx, O., Shaw, G., Deschamps, J., and Huez, G. (1989). Translational blockade imposed by cytokine-derived UA-rich sequences. Science 245, 852-855. Kruys, V., Beutler, B. and Huez, G. (1991). Translation Control Mediated by Cytokine derived UA-rich Sequences. In: Translationally regulated genes in higher eukaryotes. Ed. Robert E. Thach, published by S. Karger AG, Basel/New York, Enzyme 44, 193-202. Kruys, V., Kemmer, K., Shakhov, S., Jongeneel, V., and Beutler, B. (1992). Constitutive activity of the TNF promoter is canceled by the 3’-untranslated region In non-macrophage cell lines; a transdominant factor overcomes this suppressive effect. Proc.Natl.Acad.Scl. 89:673-677. de Sauvage, F., Kruys, V., Marinx, O., Huez, G., and Octave, J.N. (1992). An alternative polyadenylation of the 8 amyloid protein precursor MRNA regulates the translation. EMBO J. In Press. PHS 398 (Rev. 10/88) (Reprinted 9189) “Page. * ~~ ~ EF “Nuniber pages consecutively at the bottom throughout the application. Do not use suffixes such as 5a, Sb. 50294272