Document type: Resume

FF Principal Investigator/Prgram Duvctor (Last, first, middk): Witte, Pamela L. a BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed on Form Page 2. Photocopy this page or folow this format for each person. NAME POSITION TITLE Deborah A. Lill-Elghanian, Ph.D. Postdoctoral Fellow EDUOCATION/TRAINING @ezin with baccaliureats or other intial profssional education. such as nursing. and chide postdoctoral taming) DEGREE E INSTITUTION AND LOCATION GFapplicable) YEAR(s) FIELD OF STUDY Southem Illinois University, Edwardsville, IL B.A. 1986 Chemistry Southern Illinois University, Edwardsville, IL MS. 1987 Chemistry Michigan State University, East Lansing PhD. 1993 Biochemistry Michigan State University, East Lansing Postdoc 1993-1995 Immunology RESEARCH AND PROFESSIONAL EXPERIENCE: Conctuding with present position, Est, in chronological order, previous employment, experince, and honors. Inckide present membershp on any Federal Govemment pubic advisory committee. List, m chronological order, the ties, ail authors, and compkte re£rences to all pubkeations during the past thive years and to mpmsentative carer publications pertinent to this appication. Ifthe list of pubbcations in the bast three years exceeds two pages, select the most pertinent publications. DO NOT EXCEED TWO PAGES. Research and Professional Experience: 1979-1984 Medical Laboratory Technician, Bares Hospital, $t. Louis, MO Richmond, Virginia 1985-1987 Graduate Research Assistant, Department of Chemistry, Southern Illinois University, Edwardsville, IL © Investigated alternative methodologies for synthesis of substituted and fused ring : pyrrolidines 1987-1992 Graduate Assistant, Department of Biochemistry, Michigan State University, East Lansing. Mentor: Dr. RI. Hollingsworth ® Investigated the mechanism of endotoxic action of LPS with a variant lipid A structure e Determined the structure of the variant lipid A form 1993-1995 Postdoctoral Rescarch Associate, Department of Biochemistry, Michigan State University, East Lansing. Mentor: Dr. PJ. Fraker ® Investigated the effects of glucocorticoids on B-lymphocyte production and apoptotic cell death in human bone marrow « Investigated role of apoptosis in aging of B-lineage precursor cells PUBLICATIONS: 1. Holiingsworth, R.I., and Lill-Elghanian, D.A., “Isolation and Characterization of the Unusual Lipopolysaccharide Component, 2-amino-2-deox y-2-N-(27-hydrox yoctacosanoyl)-3-0-)3- hydroxtetradecanoy!)-gluco-hexuronic Acid, and its De-O-Acylation Product From the Free Lipid A of Rhizobium trifolii ANU843", (1989) J. Biol. Chem. 264: 14039 -14042. 2. Hollingsworth, R.1., and Lill-Elghanian, D.A., "Endotoxin Structure and Activity: An Old Problem From a New Perspective”, (1990) In "Cellular and Molecular Aspects of Endotoxin Reactions”, Vol. 1, (Nowotny, A., Spitzer, J.J., and Zeigler, E.J., eds.), Elsevier Science Publishers B.V., Amsterdam, pp. 73-84. 3. Kim, K., Lill-Elghanian, D.A., and Hollingsworth, R.I., "Design, Synthesis and Biological Properties of Structurally Non-Related Endotoxin Inhibitors", (1994) Bioorg. & Med. Chem. Lett. 4: 1691-1696. 4, Gazzano-Santoro, H., Parent, J.B., Conlon, P.J., Kasler, H.G., Tsai, C., Lill-Elghanian, D.A., and Hollingsworth, R.I., “Characterization of the Structural Elements in Lipid A Required for Binding of a Recombinant Fragment of Bactericidal/Permeability-Increasing Protein rBP1,,", (1995) Infect. Immun. 63: 2201-2205. PHS 398 (Rev. 5/95) . (Form Pave 6) Pave 12 FF Nurnber pages conseeutvely at the bottom throughout the application, Do not use suliacs such as 3a, 3b.