Document type: Resume

Principat Investigator/Program Director (Last, first, middie); RAPPAPORT. JAY. BIOGRAPHICAL SKETCH Give the following information for the key personnel and consultants and collaborators. Begin with the principal investigator/program director. Photocopy this page for each person. NAME POSITION TITLE Jay Rappaport Associate Professor EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training. YEAR INSTITUTION AND LOCATION DEGREE CONFERRED FIELD OF STUDY University of Pennsylvania, Phila., PA BA 1979 Biology University of Pennsylvania, Phila., PA Ph.D. 1986 Microbiology RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Concluding with Present position, list in chronological order previous employment, exparience, and honors. Key personne! include the principal investigator and any other Individuals who participate in the scientitic development or execution of the project. Key personnel typically will include all individuals with doctoral or other professional degrees, but in some Projects will include individuals at the mastars or baccalaureate level provided they contribute in a substantive way to the scientific development or execution of the project. Include present membership on any Federal Government public advisory commitiee. List, In chronelogital order, the titles, all authors, and complete references to all publications during the Past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. Professional Experience: 1979-1981 Research Technician, Wistar Institute of Anatomy and Biology, Philadelphia, PA. 1981-1986 Graduate Student, Department of Microbiology, University of Pennsylvania, Philadelphia, PA. 1987 Staff Fellow, Laboratory of Molecular Virology, Nationat Cancer Institute, Bethesda, Maryland. 1987-1989 Staff Fellow, Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland. 1990-1991 Assistant Research Microbiologist, Department of Medicine, UCSD, La Jolla, California. 1992 Assistant Research Professor, Department of MedicineGeorge Washington University, Washington, D.C. Special Volunteer, Laboratory of Oral Medicine, National Institute of Dental Research 1992-1994 Senior Staff Fellow Laboratory of Oral Medicine/Laboratory of Developmental Biology National Institute of Dental Research, Bethesda, Md. 1994-present Associate Professor, Mount Sinai Medical Center, New York, NY Honors and Awards: 1979 Graduated Summa cum Laude, University of Pennsylvania 1979 Phi Beta Kappa Society 1981-1986 Fellowship, National Institute of Health (Training Program in Cancer Research) 1991 University of California AIDS Task Force Individual Investigator Award. 1995 National Kidney Foundation (New York) Young Investigator Award Bibliography: Ts Knowles, B., Rappaport, J., and Solter, D.: Murine embryonic antigen (SSEA-1) is expressed on human cells and structurally related human blood group antigen I is expressed on mouse embryos. Dev. Biol. 93: 54-58, 1982. 2. Rappaport, J., Reinberg, D., Zandomeni, R., and Weinmann, R.: Purification and functional characterization of transcription factor SII from calf thymus. Role in RNA polymerase II elongation. J. Biol. Chem. 262; 5227-5232, 1987. Rappaport , J. and Weinmann, R.: Purine triphosphate beta-gamma bond hydrolysis requirements for RNA polymerase II transcription initiation and elongation. J. Biol. Chem. 262: 17510-17515, 1987, Khalili, K., Rappaport, J., and Khoury, G.: Nuclear factors in human brain cells bind specifically to the JCV enhancer sequence. EMBO J. 7: 1205-1210, 1988. Sadaie, M.R., Josephs, .F., Rappaport, J., Willis, R., Benter, T., Gallo, R.C., and Wong-Staal, F.: Functional analysis of the (at and trs genes of human —_ immunodeficiency virus by site directed mutagenesis. In Ginsberg, H., Brown, F., Lerner, R.A., and Chanock, R.M. (Eds.): Modern Approaches to New Vaccines. New York, Cold Spring Harbor Press, 1988, pp.311-316, Rappaport, J., Cho, K., Saltzman, A., Prenger, J., Golomb, M., and Weinmann, R.: Transcription elongation factor SII interacts with a domain of the large subunit of human RNA polymerase II, Mol. Cell Biol. 8: 3136-3142, 1988. Sadaie, M.R., Rappaport, J., Benter, T., Josephs, S.F., Willis, R., and Wong- Staal, F.: Missense mutations in an infectious human immunodeficiency viral genome: Functional mapping of tat and identification of the rev splice acceptor. Proc. Natl. Acad. Sci. USA 85: 9224-9228, 1988. Tada, H., Lashgari, M., Rappaport, J., and Khatili, K.: Cell type-specific expression of JC virus early promoter is determined by positive and negative regulation. J. Virol. 63: 463-466, 1989. PHS 398 (Rev. 9/91) (Form Page 6) Page __ 6 Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. 50654827