Document type: Resume

BIOGRAPHICAL SKETCH POSITION TITLE Professor "NAME Marcelo Jacobs-Lorena YEAR . INSTITUTION AND LOCATION CONFERRED FIELD OF STUDY University of Sao Paulo, Sao Paulo, Brazil B.S, 1964 Chemistry University of Osaka, Japan M.S. 1967 Biochemistry Massachusetts Institute of Technology, Cambridge Ph.D. 1972 Biology University of Geneva, Geneva, Switzerland Postdoc. | 1972-1977 Biolog PROFESSIONAL EXPERIENCE 1965-68. Graduate research (Master's) at the University of Osaka, Osaka, Japan. Advisor: Dr. A. Tsugita. Elucidation of the amino acid sequence of wild type and double-frameshift mutant lysozyme from T4 phage. This work confirmed for the first time the genetic code via in vivo experiments. 1968-72. Graduate research (Ph.D.) at M.LT., Cambridge, Massachusetts. Advisor: Dr. C. Baglioni. Majors areas of research: a) Mechanisms of protein synthesis using cell-free systems; b) Characterization of globin and histone mRNAs; c) Demonstration and characterization of maternal messenger RNAs in unfertilized sea urchin eggs. 1972-77. Postdoctoral research at the University of Geneva, Geneva, Switzerland, Advisor: Dr. M. Crippa. Developed a method for the mass fractionation of Drosaphila egg chambers. Initiated experiments on gene expression durin g Drosophila oogenesis. 1977-83. Assistant Professor, Department of Developmental Genetics & Anatomy, Casc Western Reserve University, Cleveland, Ohio. 1983-93. Associate Professor, Department of Genetics, Case Western Reserve University, Cleveland, Ohio. 1993-present. Professor, Department of Genetics, Case Westem Reserve U niversity, Cleveland, Ohio. FELLOWSHIPS , - Fellowship, Japanese Ministry of Education (1965-68). - EMBO long-term postdoctoral fellowship (1972-75). SERVICE - Ad hoc reviewer for the following journals: Biochimica Biophysica Acta, Chromosoma, Development, Developmental Biology, Insect Molecular Biology, Journal of Biological Chemistry, Molecular and Cellular Biology, Molecular Reproduction and Development, Nucleic Acids Research, Proceedings of the National Academy of Sciences, Science, Wilhelm Roux's Archives of Developmental Biology. - Member of the Advisory Board for the CRC Year Book of Developmental Biology (1988-1991). - Ad hoc reviewer of National Science Foundation and Research Council of Canada grant applications, - Ad hoc reviewer, NIH study section to review Fogarty International Fellowship applications (Mar 80). - Ad hoc reviewer (Feb 1985) and member (1986-90), NIH Genetics Study Section, - Ad hoc reviewer, NIH General Medical Sciences Minority Review Committee (Feb 92, Oct 92). - Ad hoc reviewer, NIH Tropical Medicine and Parasitology Study Section (Oct 92). PUBLICATIONS The following were selected from a list of 50 publications. - Housman D, Jacobs-Lorena M, RajBhandary UL and Lodish HF ( 1970) Initiation of haemoglobin synthesis. Nature 227, 913-918. - Jacobs-Lorena M and Baglioni C (1972) Messenger RNA for globin in the postribosomal supernatant of rabbit reticulocytes. Proc. Natl. Acad. Sci. USA 69, 1425-1428. - Gross KW, Jacobs-Lorena, M, Baglioni C and Gross PR (1973) Cell-free translation of matemal messenger RNA from sea urchin eggs. Proc. Natl. Acad. Sci. USA 70, 2614-2618, - Jacobs-Lorena M and Crippa M (1977) Mass fractionation of Drosophila egg chambers. Dev. Biol. 57, 385- 392, - Mermod J-J, Jacobs-Lorena M and Crippa M (1977) Changes in rate of RNA synthesis and ribosomal gene number during oogenesis of Drosophila melanogaster. Dev. Biol 57, 393-402. ‘Biographical Sketch ~~ page 1