anirudh1112/corrected-tobacco-dataset-with-ocr huggingface dataset:
Document type: Email

—-Original Message----- From: Gémez, Frank Sent: Wednesday, August 09, 2000 3:58 PM To: Fernandez, Henry L.; Garcia, Rafael (NYO); Honeycutt, Jodi Ce: Levy, Carolyn J.; Daragan, Karen M.; Chaikin, Karen; Comes, Cheryl M.; Corwin, Ginny; Spear, Kathleen K.; Brosius, Karen Subject: RE: Fires in Montana Yes, we do. But our Regional Government Affairs people take the lead in recommending actions. Ergo, I'm copying Ginny Corwin in Denver whoa recently has had experience in Los Alamos and confronts fires in several states. Normally we would not act unless there is widespread damage and victims numbering in the thousands. Were we to respond, we would need to have the particulars (tax 1.D., address, contact, phone, etc.) for the grantee. Also, we would probably check with the Red Cross to see what the needs are so we do not duplicate. Finally, we could consider a shipment of food from Kraft. So for that reason, I'm also copying Kathy Spear, who is our Task Force leader for KFNA. Let's see what Ginny says. . Thanks, Gracias, Merci, Obrigado Frank Gomez, PHC 917/663-3494 FAX 663-5475 E-Mail: Frank. Gomez@PMMC. com g9SS0Slosoz
Document type: Memo

MEMORANDUM . To: J. W, Groome = ce: A. RL Nagle 4. A. Wroughton R, fl. Sachs D. P. Christensen C, Middteton B. ly McCafferty E. A, Kully FROM: W. L. Schermerhorn DATE: Septamber 17, 1978 Purpose The purpose of this memorandum la to recommend the implementation of the FACT “one pack Iree" offer in selected markets in A Background " On August 4, 1978, a recommendation to A. R. Nagte concerning the FACT Wave 1 neeond promotion event waa approved. This recommentiation recommended that we tmptement and malntatn FACT brand awareness at the store level via LMP, SMP, and collateral point of sale material and that this emphasis be focused on package promotions and other devices which cause both conumer trial and adequate levels F of store presence. Il was further recommended that we run one pack free” coupons ! in the entire Sunday Supplement itet utilized for the first run with the exception of New York, Cleveland, and Detroit. Thia recommendation was approved; and as of the werk of September £3, 1978, Fleld implementation began on the LMP, SMP, and collateral point of anle events. | Recommendation * It is recommended that the “one pack tree" coupon event be implemented in the ROP | newspapers indicated in Exhibit f attached) early during the week of October 4, 1076. it ie furthor recommended that this coupon not be inserted on a "best food day. % NOTICE IF THE FILM IMAGE IS LESS CLEAR HAM TAI3 NOTICE, IT Is DUE TO THE WALLTE OF THE DOCUMENT AEING FILMED,
Document type: Letter

THE BERNARD M. BARUCH COLLEGE OF THE CITY UNIVERSITY OF NEW YORK 17 LEXINGTON AVENUE « NEW YORK, N.Y. 10010 533-7460 HERBERT ARKIN Professor Emeritus March 10, 1982 Mr. H. Thomas Austern Covington & Burling lal Pennsylvania Avenue N.W. P.O. Box 7566 Washington, D.C. 20044 Dear Mr. Austern: As requested, I have examined the date records consisting of labora- tory determination calculation sheets and statistical summary sheets which you represented to me to be copies of the original laboratory data sheets compiled by the Federal Trade Commission and used as the basis for figures on "tar" TPM (Dry) and nicotine yields of various brands of cigarettes as well as the final reports on these data released by the Federal Trade Com- mission. It was the laboratory data sheets for the "tar" and nicotine figures released by the Federal Trade Commission under the date December 1981 which I examined and upon which I report in this letter. TITLOQO-03493
Document type: Email

From: Jones, Lance on Tue, Nov 3, 1998 10:00 AM Subject: RE: Marlboro Leather backpacks To: Campbell, Stuart Great, that will do..Lance Ac1LO088L0z
Document type: Memo

PHILIP MORRIS U. S. A. INTER-OFFICE CORRESPONDENCE Richmond, Virginia To: A. Sanders ; Date: October 2, 1989 From: .R. Prasad Subject: .PLANNING MEETING: ABSTRACT OF PRESENTATION - PROJECT ART Attached is an abstract of the Project ART presentation at the Planning Meeting on September 21, 1989. This covers the presentation of three Speakers (R. Prasad, H. Spielberg, D. Leyden). “4 a aeel attachment Ro. cc: H. Alonso D. Knudson 29 T60ce202
Document type: Report

REPORT B1033 / P 0500/3204 940105 PAGE 33 LOCATION EPITHE- FINDING STAT. CONTROL 1R4F URSUS-35 left lung respi-~ goblet cell M 0 ratory hyperplasia SE 0. TEST incidence 1/8 1/7 4/8 3/8 3/8 TABLE 12 HISTOPATHOLOGICAL FINDINGS, LUNG, END OF POSTINHALATION PERIOD Remarks: Cochran-Mantel-Haenszel test followed by Cochran-Mantel-Haenszel test, 1R4F versus sham, URSUS-35 versus sham 931111 15:37:50 P. 1 USER DISK: {MMA]HIST CMHR 3204.LIS;3 BvETE41 902
Document type: Memo

Ko ollard, MEMORANDUM 7/13/95 TO: M. Borsini FROM: K. Paitakis SUBJECT: Style Special POS Pricing - Texas Test Market The following is a list of cost estimates for the Vinyl Decal and 3 piece Mobile which we are considering for the Texas test market. I have also received projected quantities from Sales Planning as listed below. The costs are as follows: Item Quantity Cost Per Unit Total Cost 10 1/2" Vinyl Decal 6,600 $7.25 $47,850 3 Piece Mobile 6,000 $5.38 $32,280 The cost per unit listed above is based on a quantity of 2,500. Therefore, the actual cost per unit will probably be slightly lower. As you are aware, mechanicals for the decal, mobile and dummy pack are currently being developed by Bob DeBlasio. Receipt of the decal and mobile mechanicals are expected by July, 24, 1995. Please feel free to give me a call if you have any questions! Kp ce: A, Sadovnick C. Humphrey C, Lucente j. Tatulli K. Sparrow C. Sanfilippo L. Giordano B. DeBlasio zezenete
Document type: Report

: | W. ALTON JGNeS CELLSCIERCe CENTER Leonard FE. Benade, Ph.D. Grant #1719 Description: Dr. Benade proposes to isolate and characterize a gene which suppresses the action of the oncogene Kirsten RAS. He will do this by first isolating human cells, HOS, with two copies of RAS so that mutants which lose oncogenecity will not be due to loss of RAS. He will then look for revertants which no longer express the transformed phenotype after mutagenesis. He will partially select for such cells using oubain. Revertants are more resistant. He will check these revertants for rescuabable virus, inability to grow in agar and inability to produce tumors in nude mice. Such cells will be fused with mouse NIH 3T3 cells which have been transformed with Kirsten sarcoma virus. Hybrids with suppressed oncogenecity will be selected with oubain. Since human chromo- somes are preferentially lost in mouse-human hybrids, the suppressed cells should with time have Tess and less human DNA. Human DNA will be isolated from such cells, using alu sequences as a probe. This DNA will be used to transfect Kirsten transformed mouse cells and suppressed cells will be selected with oubain. Dr. Benade expects to eventually clone the suppressor gene. Critique: The idea is a good one and the isolation of a gene which sup-. presses an oncogene will add greatly to our understanding of carcinogenesis. He has a very good publication record. Overlap with pending NIH application should be examined. Recommendation: Approval - Merit A. Par H. Sato, > per 50244186
Document type: Email

-----Original Message-—- From: Van Malssen, Mark A. Sent: Friday, August 18, 2000 1:15 PM . To: Cummings, Lewis M.; Herald, Earl N.; Montgomery, Charles T.; Jones, Dick E.; Green, Diane F.; Parrish, Milton E.; Tobey, Becky As Matthews, Clay T. Ge: Miller, Doug; Davis, Gail Subject: Records Coordinator Training As you are aware PM USA is implementing a new records management program and the people listed in the attached file have been appointed Records Coordinators for your respective areas. Records Coordinator training which lasts a full day will begin in mid September. The training consists of a half day on the new process and a half day on using the Electronic Récords Management computer system (ERMS). Because hands on computer training space is limited and therefore scheduling is a little difficult, I need some input from you all on your Records Coordinators availability. Please review the dates and times below and let me know which of these sessions they cannot attend.Please let me know by Tuesday 8/22.. After | here from you all | will notify you and the Records Coordinators on the sessions they have been scheduled for. If there are any changes fo the list of Records Coordinators please let me know by 8/30. On August 30th I will be giving the Records Coordinator list to IS so they may begin the process of granting system permissions to these people. When attending training, each Records Coordinator should bring a list of people for the departments they will support. This list will be used by them to begin granting system permission to there people during the hands on ERMS training. Please help your Records Coordinator procure this list prior to attending the training. Records Process Training: September 13, 8:30 -12 Records Process Training: September 21, 8:30 -12 ERMS Training:September 13, 1-4:30 ERMS Training:September 22, 8:30 - 12 ERMS Training:September 22, 1-4:30 Thank you for your help. Mark << File: Records Coordinators.xls >> ASTI LE0P8OZ
Document type: Resume

Kaprio 1 CURRICULUM VITAE Personal Information: Name in full . Jaakko Arthur Kaprio Date of birth April 23, 1952 Place of birth Helsinki Sex Male Marital status Married Department address University of Helsinki Department of Public Health Science Haartmaninkatu 3 SF ~ 00290 Helsinki 29 : Finland Department phone 90-418 511/326 Education: High School General Certificate of Education , (Cambridge) Advanced Level, 1970 University University of Helsinki Lic. Med 1976 Positions Held: 1983 - Research assistant, Finnish Medical Research Council 1976 — Assistant, Dept. of Public Health Science, University of Helsinki Membership in Professional Societies: scmpersnip in Professional Societies International National International Society for Twin Studies Chairman of Nominating Committeé 1984-1986 European Society for Human Genetics Finnish Medical Association Duodecim Association for Medical Genetics Finnish Antropological Society 50106572
Document type: Report

REYNOLDS TOBACCO CALLS FOR COMMON SENSE REGARDING ADVERTISING ISSUES The debate over cigarette advertising in magazines needs a big dose of common sense. Critics of our advertising don’t want children to see cigarette ads in magazines published for and read by adults. However, the only way to guarantee that no child ever saw a cigarette ad would be to completely ban cigarette advertising. The real issue is whether cigarettes should be treated as legal products for adults, and whether manufacturers have the right to communicate with adult smokers. Cigarettes are already the most restricted consumer product in terms of marketing and advertising, but we have the legal right to advertise in adult smokers in publications that are not youth-oriented. Does seeing a cigarette ad cause children -- or adults -- to begin smoking? Common sense tells you no. Government and university studies show that peer pressure and family influence are the primary factors in smoking initiation. And common sense tells you that the vast majority of tobacco messages that youth are exposed to today are anti- smoking messages. So what would further restricting cigarette advertising — or banning it — accomplish? It would be one more step in attempting to make smoking more socially unacceptable — and once again, treating a legal product as if it were illegal. It would deprive cigarette manufacturers of a constitutional right, but it would not resolve the youth smoking issue. Our standard is to advertise only in publications in which at least two-thirds of the readership is age 18 or older. Further, we evaluate the editorial content of the publications over time to be sure the topics covered are of interest to predominantly adult audiences. We review the other advertisers who appear in those publications to ensure that most are for products which primarily are purchased by adults. We also review factors such as the publications’ circulation dynamics and method of distribution. The same magazines we advertise in carry ads for other adult products — such as alcohol, household appliances, and furniture. In 1998, the major tobacco companies signed an agreement with the States’ attorneys general that enacted sweeping bans and restrictions on cigarette marketing. This agreement does not prohibit us from communicating with adults who choose to smoke. £980 bOtCcS
Document type: Memo

PHILIP MORRIS U.S.A. INTER-OFFICE CORRESPONDENCE 120 PARK AVENUE, NEW YORK, N.Y 10017 TO: Daniel Tso . pate: September 18, 1986 From: _.. Karen Eisen. . ; . 7 cw QZ: Reopee PM Blues Pack Test HP Fos Toe SUBJECT: ues Pack Tes . Y’, Sey wr Oe This memo reviews the study design and rationale behind conducting a package design test which includes Leo Burnett's suggested pack for PM Blues. While an ad/pack test is planned, a package design test would provide Marketing with results in a shorter time frame and serve as an early read of smoker interest and choice within the packaging alternatives. “The test would follow the same format as previous Blues pack test. 300 full flavor menthol smokers would be interviewed with 75% 18-34 years of age and 25% 35-54 years of age. The sample would be evenly divided by sex and size of cigarette smoked. Eligible respondents would be exposed to each of the three packs, one at a time, on a rotated basis. Following the exposure and rating.of the packs monadically, participants would be shown the three Blues packs — side-by-side and questioned as to their preference and reasons why. Consumers would then be exposed to a few unfinished ads; more specifically, just pictures of people smoking, and then they would be asked to select the one pack which best fits with the pictures of the people. Daniel, I will need six sets of packs. I already have the ad pictures needed for this test. KE/isw Sats Pe qe SO0vsgerOZ ‘
Document type: Email

207278 14S Printed By: Kelly Rubin MAY CONTAIN CONFIDENTIAL WORK PRODUCT, JOINT DEFENSE, OR PRIVILEGED ATTORNEY-CLIENT COMMUNICATIONS IN CONNECTION WITH ONGOING AND THREATENED LITIGATION 2 Susanne Addy == 03/30/99 01:04 PM COOKER ECD EHO SHEET EHEC HOHE To: Kelly Rubin/PhilipMostis/Bravo@Bravo cc. Subject: New Madel Protective Order Keily: this is the resend, as we discussed.
Document type: Email

2085793441 Townsend, Sue V. From: Burnley, Harold G. Sent: Tuesday, January 08, 2002 12:44 PM To: Stariha, Craig E. Subject: RE: RTO Summary data for last production week 12/30/01 - 1/6/02 How about some time tomorrow morning (Wednesday)? Harold
Document type: Email

From: Engel, James M Sent: Tuesday, January 08, 2002 10:30 AM To: Nothofer, Mike Subject: Discount Share Trends ilk DsctShiTrends.xls James Engel Marketing & Sales Decision Support 100 Park Avenue 14th Floor 917.663.3227 2714401005
Document type: Email

-----Original Message----- From: King, Valerie A. Sent: 7 mars 2001 00:32 To: Andriot, Michelle D.; Carmines, Edward L.; Dempsey, Ruth; Elves, Robert G.; Gaworski, Charles L.; Hirnikel, Daniel J.; Kinser, Robin D.; Lau, Raymond W.; McKinney, Willie J; Nixon, Gerry M.; Podraza, Ken F.; Reininghaus, Wolf; Sanders, Edward; Tricker, Anthony; Walk, Roger A.; Werley, Michael S.; Viol, Brigitte Subject: Milestone Status Report 1/1 - 3/1 Dear all: As promised, attached please find the milestone status report for the period 1/1/01 - 3/1/01. The attachment details those project milestones due to be completed by March ist. As with last year, we will continue to use reporting by exception. If the milestones were met, there is no need to respond. If, however, you have a missed or delayed milestone, | need from you by noen on : * anew target daie for the missed milestone, and ¢ a brief but specific explanation of why the milestone was not met. lt a delay is related to a resource issue (internal or external) please be sure to indicate this in your feedback. Those milestones in the attachment for which | do not receive any indication of a delay will be marked “complete” in the database after 3/14. Keep in mind that if a delayed milestone is causing other target dates in your project to slip, you need to provide me with updated dates for those milestones as well. You can include that in your feedback to this report or send me that information separately (email or updated project sheet; either is fine). Let me know if questions. Thanks, Valerie Frau Viol: Could you please circulate this to the INBIFO project leaders as appropriate. Thanks. x | Milestone 1-4_01 report.xls V88092bS0S2
Document type: Email

From: Arce, Miguel Sent: Monday, November 29, 1999 12:37 PM To: Bayliss, Elissa L. Ce: Murillo, Joe; Garcia, Elisa Subject: MIAMI GRAND PRIX RACING SUBJECTS Importance: High Elissa: As per your instructions of this morning attached please find samples of what was done with Indy transparencies concerning last years Miami Grand Prix promotion in Latin America. As described to you on my note of the 23rd, we would like to use new photos for posters, banners, counter displays and print (in Latin America only; Mexico, Central America, Colombia, Ecuador and the Dominican Republic). Please reply as soon as possible as this is a time sensitive issue for us. Thank you for your help and support. Best regards, Miguel V0OZ890L0202
Document type: Memo

RIRT INTEROFFICE MEMORANDUM Subject: Freon 123/Freon 11 Date: April 10, 1990 Residue Decay Study in Packaged Cigarettes To: Michael F. Borgerding From: Rhenda H. Steele At RJRT, once tobacco is expanded, this tobacco can be used to make cigarettes in approximately two to six hours. Once cigarettes are made, the cigarettes can be in the consumer's hand in as little as three to four weeks, although the industry average is three to four months. With these times in mind, the following sampling points have been chosen for the packaged cigarette residue decay study: Day 0 (remove cigarettes from freezer) Day 1 Day 4 Day 7 (1 week) Day 14 Day 21 Day 28 (1 month) Day 42 Day 56 (2 months) Day 70 Day 84 (3 months). These data are needed in order to estimate smoker exposure to Freon 123 by the August decision date. It is understood that this study will probably need to be repeated once PT&D optimizes the Freon 123 expansion process in order to obtain a more accurate curve for consumer exposure assessment. , cc: A. W. Hayes ui R. L. Suber > D. S. Saunders e D. C. Rees a D e Fox = uw Ww 95°F / 609, CH a “7 GCmsD | Pak ot tat don pert ( ne i cal
Document type: Email

-----Original Message---- From: Sent: To: Subject: Sensitivity: fyi Piskor, Stephen K. Tuesday, September 26, 2000 14:05 AM Rush, Sonya C. FW: Age Verification/Gamet Bar Pam. Confidential . V66ELPLS80Z
Document type: Report

| os 2! APT SUPPORTING PROCESSES Tie WEEKLY STATUS ats Ta JUNE 29 - JULY 3° CEO DET : SEU Ed ADDR SEE ONLY Neo LK ms tte VW. SUBSTRATE DEVELOPMENT: Fn GRACE: A technical meeting is scheduled for this Thursday, July 9, with Mr. Joe Porinchak. The primary topics of discussion are: 1. Results of RJRT's physical and performance analysis of recent samples. These results will be used to plan future technical development direction. 2. Determine a schedule for future development. 3. Discuss results with flow agents and plana development schedule for obtaining production quantities of Syloid with larger particle size. An extended test run on the Bosch capsule filling machine started this morning, 7/6. The test run is using Grace D2 substrate, with the Tox. II load. Grace Syloid 63 FF is applied, by hand at 0.6% by weight, as a flow agent just before actual use. The material was loaded in Shed 112. ALCOA: The material produced by Alcoa at Fuller, early in June, was received at Lawrence Transfer, late last week. A total of nine drums were received, equalling a little less than 3,100 lbs. This material will be brought to 602-4 early this week and drum samples will be submitted for complete physical analysis. KAISER: A technical meeting was held at Kaiser's facility in Baton Rouge, on June 30. The discussion resulted in the following development schedule: ITEM KAISER RJR COMPLETION FEEDBACK 1. Matrix Three Screening 7/21 8/25 2. Computer Program Matrix 9/5 10/23 3. Manufacture Feed/500 lb. test 9/3 4. 500 lb. Sintering via Magneco 9/22 10/13 5. Manufacture Feed/i0,000 lb. test 11/13 6. 10,000 lb. Sintering via Magneco 11/24 12/26 7. RIRT Receives 10,000 lb, 12/5 1/5 8. Full Qualification . 1/5 6$20 £0995 page 1
Document type: Report

¢ LM aa he Aesth Coumats om LMA: Mia € i helt brkchon 17 August 1998 Comments on Risk Mitigation Measures for Phosphine Fumigants Peepared by: Inventa Corp., Pestcon Systems, Inc., & Degesch America, Inc. Introduction . ‘The present Applicator’s Manuals for metal phosphide fumigants were developed in the late 1980's as part of the Label Improvement Plan of the Reregistration Process. Substantial technical input for these Manuals was provided by the food industry, registrants and EPA. Hours of discussions, careful thought and written communications, and arguments, led to the final document. The registrants believe that the Manuals have served well for their intended purpose - the safe and effective usc of phosphine fumigants for protection of stored commodities and for control of burrowing pests. Further, we believe that the present Manual and regulations do not need extensive revision and new risk mitigation measures should not be incorporated unless a need for them has been established on a scientific basis. Critical comments on the data base used in development of risk mitigation measures proposed by EPA have been made in the registrants’ 7 August 1998 submission to EPA entitled “Comments on EPA's Human Health Risk Assessment", dated 22 June 1998. We feel that the present Manuals are readable, delineate all present-day requirements and, along with the certification program for training of persons applying restricted-use pesticides, have enabled the attainment of an excellent safety record, especially when compared with other fumigants. L Establishment of a Competent Person Most or all of the suggested requirements listed by EPA in this section are already covered in the existing Applicator’s Manuals, Present labels require pre- inspection of the site and development of an overall plan for the fumigation by a certified applicator. This plan, in order to be a good plan must include placarding, notification, monitoriog and other tasks necessary for the safe and effective use of the fumigant. The registrants would have no objection to rewording sections of the present Manuals which, perhaps, might place more emphasis on this requirement. Copies of current Manuals can be provided to EPA, if requested. There are two chilling suggestions made by EPA in this section on which the registrants would like to comment. The first is making the “competent person" legally liable for safe and effective use of the fumigant. Is EPA suggesting fines, ale 10 ‘d SeehecObS ‘ON XI 6°69 poets HOSHI3d «Hd @P:20 SM 86-90-100 es i mm iim iii A mi iia atta ci
Document type: Letter

September 29, 1992 Dr Harmon McAliister Council for Tobacco Research 900 Third Avenue New York, NY 16022 Dear Dr. McAllister J am writing this letter to inquire about the possibility of a phase out fund for the CTR grant 2003 about the purification of the adipogenic factor. I am aware that the renewal of this application was not funded. However, since the submission of the proposal, we have made considerable progress towards the complete purification of the hepatocyte-derived adipogenic factor. If we could obtain a phase out fund of 15,000 dollars, this will allow me to continue supporting for 6 months the visiting scientist from Japan who has been carrying out this project. This will give him the opportunity to complete the very difficult but very important purification of the adipogenic factor for which he has worked so hard. Unfortunately, the Cell Science Center is going through a financially very difficult time so that people that would be otherwise supported in the interim by the institutional fund do not have this opportunity anymore. This will also allow us to obtain additional data so that we can write application to support the whole project. I am aware that this is a very exceptional request but because of the long standing interest of the Council for innovative research, I am hopeful that this request will be favorably evaluated. I will be very happy to provide you with additional data on the progress of the purification of the adipogenic factor if you need them. I would like to thank you for your kind consideration in this matter. Sincerely yours, f GOb2hk Pe —— ; Ob epg ir ane : : iid)” Ginette Serrero PhD Lan A wi yi {7 wf Senior Scientist S vip of Wy, i fi AN AFFIRMATIVE ACTION/EQUAL OPPORTUNITY EMPLOYER 40015160
Document type: Resume

BIOGRAPHICAL SKETCH ANN KATHERINE DALY Date of Birth October 17, 1957 i ion BA in Biochemistry (1978, University of Dublin); PhD in Biochemistry (1982, University of Dublin), Present appointment Senior Rescarch Associate Department of Pharmacological Sciences University of Newcastle upon Tyne UK (since March 1989) Previous appointments Research Associate, Medical Molecular Biology Group and Department of Dermatology, University of Newcastle upon Tyne, UK (1984-1989). Postdoctoral Rescarch Assistant, Department of Molecular Biology, University of Geneva, Swilserland (1982-1984). Postdoctoral Research Fellow, Department of Biochemistry, Trinity College, Dublin, Ireland (1981-1982). Selected Publications Daly A.K. & Mantle T.J. (1981). Multiple forms of aldchyde reductase in ox kidney. Biochem Sov Trans 9, 295, Daly A.K. & Mantle T.J. (1982) Purification and characterisation of the multiple forms of aldehyde reductase in ox kidney. Biochem J 208: 373- 380. Daly A.K. & Mantle TJ. (1982). The kinetic mechanism of ox kidney aldehyde reductase with D-glucuronic acid. Biochem J 205: 381-388. Tipton K.F., Rivett AJ., Daly A.K. & Mantle T.J. (1982). Kinetic studies with aldehyde reductases In: Enzymology of carbonyl metabolism: aldehyde dehydrogenase and uldo/keto reductase. (Weiner, H. & Wermuth, B. eds), Alan Liss, New York, Lewis C.D., Lebkowski J.S., Daly A.K. & Laemmli U.K. (1984). Interphase nuclear matrix and metaphase scaffolding structures. J Cell Sci Suppl 1; 103-122. Daly A.K. & Redfern C.P.F, (1985). The binding of retinoic acid to nuclei and nuclear subfractions. J Javest Dermatol 84: 446, Worrall D.M., Daly A.K. & Mantle T.J. (1986). Kinetic studics on the major form of aldehyde reductase in ox kidney: a general mechanism to explain substrate-dependent mechanisms and the inhibition by anticonvulsants, J Inzyne Inhib1: 163-168.
Document type: Memo

at iy February 20, 1975 _ MEMORANDUM TW: Fred Panzer FROM: Marvin Kastenbaum RE: Meeting of Washington Statistical Society Date: February 12, 1975 . Place: Building 31, NI Speaker: Dr. Max Halperin, Chief of Biometrics ° National Heart Lung Institute Chairman: Tavia Gordon ; Topic: Problems at the Interface of Epidemiology and Clinical Trials: the. Design of the Multiple Risk Factor Intervention Trial (MRFIT) The announcement of this meeting had the following explanation appended: . "The MRFIT, which is a study of the effectiveness of lowering blood pressure, serum cholesterol and cigarette smoking in reducing the incidence of heart attacks is based on prospective experience in human populations. The method by which the observed experience is used for designing the trial, and the methodological diffi- culties involved, are the subject of this talk." In his introduction,. Tavia Gordon said that the topic which Dr. Halperin was going to discuss is “complex and messy.” Dr. Halperin's opening statement went something like this. “only two people in the world understand the problems of MRFIT, and {turning to Gordon) I am not sure about you. (Turning to the audience) and I'm not sure about me." “TIFL 0406048 -—
Document type: Email

From: Mitchell, Marilyn To: Braxton, Paul; Campbell, Donna S.; Fansler, Susan; Hickman, Tommy L.; Laughter, Sandy V.; Lyons, Mary M.; Mize, Kaye; Parduc, Annette; Stabler, Belinda A.; Tinsley, Skip CC: Allen, John S.; Armstrong, Sicphen T.; Beard, Ken; Brown, Lisa; Burcham, J. Randall; Carpenter, Carolyn; Cook, William (Rudy); Davis, Cindi; Edgell, Glenda L.; Gilchrist, Steve N.; Guess, Hal; Hauser, Fedrecia U.; Hutchens, Ronald; King, Ricky L.; Martin. Timothy G.: McElveen, R. Donnie: Norman, Steven M.; Phillips, Percy: Potter, Denny: Roberts, Diane; Robinson, Wesley E.: Sanders, Karen; Simmons, Alan: Wilhcim, Douglas E. BCC: Primary Date: 4/12/2000 1:20:18 PM Last Modified Date: 2000-May-15 16:48:52 Last Touched Date: Sent Date: 2000-Apr-12 13:20:11 Received Date: 2000-Apr-12 13:20:18 Subject: For Review/Approval - Procedure Note 99-15R2 Attachments: 99-15R2 brown L.doc PN 99-15R2: Adjustment to Pack Menthol Spccifications-Revision of Menthol Extraction Procedure (Lisa Brown) RJR0000001315002811 70027 9442 Glel ¢e6ees
Document type: Report

OSHA The Occupational Safety and Health Administration (OSHA), of the United States Department of Labor, has issued a Notice of Proposed Rulemaking on indoor air qualitiy (IAQ) and tobacco smoke. It would impose broad requirements on employers regarding air quality and the operation and maintenance of heating, ventilation, and air conditioning (HVAC) systems. It would effectively prohibit smoking in indoor public places. ‘ Smoking would be banned in restaurants, bars, private clubs, retail establishments,, office buildings, government buildings, bingo parlors, bowling alleys, casinos, hotels and motels, sports arenas, and every other indoor space except residences. It is the most far-reaching proposed smoking restriction in history, and would override every less restrictive state and local restriction currently on the books. It would apply to EVERY workplace, regardless of size, with the exception of sole proprietorships (one self-employed person, with no employees) . The only “concession" to the reality that 45 million adult Americans smoke is a provision for smoking areas which is so burdensome they are unlikely to be provided by more than a handful of employers, if any. Smoking could legally take place only in ‘separate, designated pon-work areas, which are maintained (ventilated) at a negative pressure compared to surrounding areas and separately exhausted to the outside. Further, no employees could enter the area for work purposes. In other words, they could go into the designated area for a “break," and smoke a cigarette, but not to work. Thus, a restaurant or bar could not have a smoking room in which food or drinks were served, or from which dirty dishes or glasses were removed by workers. Even routine cleaning of the designated area/room would have to be done during hours in which no smoking were taking place. In other words, if this rule is allowed to take effect, there will no longer be a single bar or restaurant anywhere in America (with the possible exceptions of Indian reservations, the United Nations, and foreign embassies and consulates) in which you can be served food or drink while smoking a cigarette (or pipe, cigar, whatever). ezee Loses
Document type: Email

~-—--Original Message—-—- From: Muller, Christine Sent: Friday, December 03, 1999 12:07 PM ; ; . To: Bertram, David; de Nijs, Daan; Dragomirescu, loana; Abidjan, Office; Dubois, Thomas; Fabrio, Sanja; Fraser, Duncan; Kocdag, Kursat; Mand, Surinder; Nelson, Chris; Ronat, Luc; Pantet, Raymond; Ballout, Jihad; Bamboukian, Albert; Baroudi, Bisharah G.; Chytil, Jakub; David, Peter; Duzel, Cahit; Erten, Cagatay; Golab, Elzbieta; Houminer, Akiva; imre, Peter, Jackson, James; Janku, Ales; Kiss, Emese; Kollarova, Ivana; Krajnc, Barbara; Paquier, Louis; Reavey, Richard: Sivakova, Danica; Szeker, Judit, Tuzecan, Temucin; Withwer, Thierry; Wyszynski, Robert Gc: Berlind, Mark; Hurwitz, Even; Little, Greg; Nunley, Chip (new Retix); Reardon, Michael; Child-Villiers, Roddy; Csakanyi, Edit; Ozugul, Nurtac; Petruzzi, Margherita; Coffey, Kathy; Pabst, Joanne; Maiolatesi, Dagmar; Rossier, Gloria; Micenko, Elfen; Blanc, Janet; Currat, Karen; Mora, Susana; Groux, Corinne; Wanner, Madeleine; Buchillier, Anne Subject: CEMA ISSUES AND COMMUNICATION WORKSHOP - 8-10 DECEMBER 1999 Please find hereunder further information regarding the workshop as well as the final agenda which now includes the direct numbers to the office on site. Also attached is the list of participants (Barbara / Akiva - your group has changed). For those of you interested, attached is also the link to the Railirack site with the timetables for trains between Wokingham and London and a map locating Wokingham. Piease review the transportation arrangements attached and get back to me if you have any changes. The hotel has a fitness center and free car park facilities The dress code throughout the meeting will be casual (no ties needed) You will be expected to cover for your room charges and extras (rooms are at GBP 150-165) Transporiation and meals will be covered by the masterbill Because of the numbers involved the hotel has requested the following arrangements for dinners: Dinners: 7th December dinner has been organized in the Conservatory between 19:00-20:00 (set menu) Dinners: 8th December dinner has been organized for 19:30 in the Conservatory (set-menu) | a | | Aw-4 con towne agendadoc Transportation.doc: particip-jist.doc. ig Railtrack Travel 12866000. TIF Timetable.uri,.. to://195.92.214. inf Looking forward to seeing you in Wokingham Christine VZLZE0907202
Document type: Email

From: Berman, Michelle [michelleberman@hfmmag.com] Sent: Friday, March 02, 2001 4:27 PM To: ‘nancy.w.conrad@pmusa.com' Subject: Procedures- Discussion Points procedures & guidelines.doc Hi Nancy, In advance of our phone call on Monday | thought | would send the attached. It is our recommendation on procedures. | would like to review it with you and add or eliminate based on the outcome of our phone discussion. Thanks <<procedures & guidelines.dac>> Michelle S. Berman VP Group Publisher Hachette Filipacchi Custom Publishing 460 West 34th Street New York, NY 10001 (212) 560-2101 2702800465
Document type: Email

---—Original Message---— From: Levy, Carolyn J. Sent: Friday, January 26, 2001 9:53 AM To: Ostern, Eric; Chaikin, Karen; Fernandez, Henry L. Ce: Hayes, Kim; Manning, Michelle P.; Daragan, Karen M.; Cusato, Denise Subject: your 2001 plan presentations could | pis get a copy of each of the presentations you have presented to the YSP group thus far? 135 HLOTL69S80C
Document type: Email

2078346945 From: Becker, Deborah on Mon, Dec 9, 1996 7:58 AM Subject: FW: Vent. Guidelines 11/26/96 To: Berlind, Mark; Winokur, Matt Mayada is correct in her statement regarding conflict of these draft ventilation guidelines with respect to "adapted" individuals. The ASHRAE comments state "There is no justification or clarification of why adapted occupants became the basis for determining ventilation rats. The strongest scientific basis for determination of ventilation rates is based on unadapted persons, There is no standard method to determine how an adapted occupant of a space can be satisfied or dissatisfied with the indoor air quality, particularly in relationship to other confounding indoor environmental factors..... We need to resolve this difference. Otherwise I think the guidelines look great. They sure are expanded in content since our meeting together.
Document type: Report

as ‘ A, dochebt Grant Application # 1124, Peter V. Tishler, M.D., Peter Bent Brigham Hospital, Boston, Massachusetts. "Aryl Hydrocarbon Hydroxylase and Occupationa! Exposure to Asbestos"! This tnvestiaator intends tn measure Tymohobsast AHH Inductbility tn subjects with known heavy exposure to asbestos for many years. Thelr findings will be compared with an age-matched u.exposed control population. The exposed group will tnelude 145 smokers and 55 non-smokers, a number which they belleve will be sufficient to provide prospective assessments of the relationships between AHH Enducibility and the development of disease known to be related to asbestos (lung cancer, and mesotheliomata) . Spectrofluoromet ric methods will be usd for the determination of AHH In cultured lymphoblasts. Studies will be rer-:ated on a sub-sample of the total population. Finally, Dr. Selikoff, a physician with extensive experience with the asbestos problem, will be a pare! clnant in the study through the provision of follow-up, presumably over a long perlod of time, on the subjects so that any correlation between asbestos associated lung disease and AHK fnducibl lity might be determined. Investigations will be conducted at the Channing Laboratory of the Harvard Medical School which Is located at the Boston City Hospital. The laboratory facilities appear to be adequate. , . Samples will be collected by Dr. Self koff and his associates and there is a letter Indicating the collabcration agreement with Dr. Seltkoff. There is only one technical point that | would like to ralse and thts pertains to the budget justification. Specifically, the specimens will be obtained In New York City by Dr. Seltikoff during the course of reqular examinations on the subject populathn. The fnmvestiaator ralses a problem about safe arrival of samples in Boston and 1! assume by this that he Ts concerned about the shipping and viability of these lyrmhocytes. | do not foresee that this should be a serfous problem since we have shipped samples success fully on nurerous occastons. f would think that this minor problem could be resolved with the saving of stonificant funds which miaht otherwise be expended through Boston to New York and return trips by personnel. This project appears to be well thought out, and the investiaator definitely appears to have Insight Into pertinent aspects of the Issue. Finally, It would be of value to learn about the imortant problem of/f pres os, AHH, cigarette smoking, and asbestos related diseases. sn tig?
Document type: Report

ROJECT GT ° PrRoDUCT oP T e | - + MOKERS - RESULTS OF FIRST WAVE OF TESTING WERE PRESENTED TO BRAND AND Red. THESE PROTOTYPES (WITH SHORT-TERM TECHNOLOGIES) MET ACTION STANDARD ON ATTRIBUTE PERFORMANCE, RUT NOT ON OVERALL oot ACCEPTANCE: . win sow / 1) ALL THREE GT PROTOTYPES WERE PERCEIVED TO BE AT LEAST ie \ COMPARABLE TO MARLBORO LTS; ON SMOOTHNESS AND TOBACCO TASTE: L j 2) ALL PROTOTYPES HAD LOWER THERMOMETER RATINGS ~ 49% to 52% versus MaRLRORO’S 582- AMONG MARLBORO SMOKERS THE RESULTS WERE SIMILAR- can SECOND WAVE OF TESTING (INTERMEDIATE TECHNOLOGIES) WAS MAILED or wt ~ out 5/18; RESULTS TO RE PRESENTED WEEK OF 6/29. t ut a “s ey i ‘ w gi my Ayo — e a oe c y j e FF Taste at FFLT - 18+ FENM SMOKERS - FIRST WAVE OF TESTING WAS MAILED OUT 5/4; RESULTS TO BE PRESENTED WEEK OF 6/15- | es 3 * nd i} lo oo Y . A re ante | K Ee wile ° je? oe a wt \ / we | fe ia 2 ’ . ot i a) oP aw / . \ a Oo \\ e : a p” aa be oe y" cot ll Lf 15 a ‘) a i , “> ~o7 co _ a) Uv ad ~ Oo 4 \~- (er a ore . oO “ T x - , c ,
Document type: Email

From: Pham, Xuan Sent: Wednesday, September 29, 1999 11:36 AM To: Ware, Keith Ce: Wrenn, Sue; Smith, Barry S.; Chemla, Mare R.; Lovett, Ron; Joshi, Manju D; Brown, Janelle P.; Green, Diane F.; Jeter, Kirk FW: BETA-EUROPE alo below and advise us on quan Philip Morris USA Phone: (804) 752-5643 Page : (804) 215-5643 Fax : (804) 752-5600 2078637110
Document type: Email

From: Lenling, Amy Sent: Thursday, August 09, 2001 9:57 AM To: Desel, Paula; Whidden, Roger; Suter, Eric Subject: Senate Confirms OSHA Nominee VEESITIS80C
Document type: Report

4yG-Chromo-Sister Chrom-In Vitro Setooer, 1983 PURPOSE The sister chromatid exchange (SCE) assay detects the ability of a chemical to enhance the exchange of DNA between two sister chromatids of a duplicating chromosome. The test may pe performed in vitro, using, for example, rodent or human ‘cells, or in vivo using mammals, for example, rodents such as mice, rats and hamsters. Il. DEFINITION Sister chromatid exchanges represent reciprocal interchanges af the two chromatid arms within a single chromosome. These exchanges are visualized during the metaphase portion of the cell cycle and presumably require enzymatic incision, translocation and ligation of at least cvo DNA helices. IIL. REFSRENCE SUBSTANCES Not applicable. IV. TEST METHCD Ae Principle Following exposure of cell cultures to test chemicals, they are allowed to replicate in the presence of promodeoxyuridine (3rdU), followed by treatment with colchicine or colcemid to arrest cells in a metaphase- like stage of mitosis (c-metaphase). Cells are then harvested and chromosome preparations made. Preparations are stained and metaphase cells analyzed for SCEs. : 3. Description In vitro SCE assays may employ monolayer or suspension cultures of established cell lines, cell strains or primary cell cultures. Cell cultures are exposed to test chemical and are allowed to replicate in the presence of BrdU. Prior to harvest, celis are treated with a spindle inhibitor (e.g. Colchicine or Colcemid *) to accumulate cells in c-metaphase. Chromosome preparations from cells are made, stained and analyzed for SCEs. 1 SO88 O860S
Document type: Report

SEDRPTO3 SENSORY EVALUATION TEST REQUEST NO. 1302 Page % 11:47:19.7 11/09/90 Project Name: XA/QC PROTOTYPE Program No.: 222 CHARACTERIZATION - PETS VISITOR EVALUATION Requested by: Daniel B Kurtz Request Date: 11/08/90 SED Proj Leader: Daniel Kurtz Prod Location: SEE DESCRIP Make Date: 11/01/90 Results Needed: 12/20/90 Test Objective: To determine if there are differences in how visitors perceive machine generated ETS from eight different products (a conventional product, six XA prototypes, and one QC prototype). The results from this test will provide the XA project with product development direction. Product Descriptions: PD04009-AB - CAMEL LIGHTS 85 product. PDO3886-AB - XA prototype with 30% charcoal inner wrap, 6 Coresta CMC outer wrap and CAMEL Lts. blend. PD03988-AA - XA prototype with 50% charcoal inner wrap, 3 Coresta outer wrap (TOD5560) and CAMEL Lts. blend. PDO03988-AB - XA prototype with Tobacco inner wrap, Ecusta TOD5504 outer wrap and CAMEL Lts. blend. PD04022-AB ~ XA prototype with tobacco inner wrap with 6% cutrate, K-C CMC outer wrap and CAMEL Lts. blend. XA prototype with 2 Coresta CMC paper, 70% CAMEL Lts. blend with 97-B filer (G7 process, tobacco/charcoal/CaCo3). FL900254-AA FL900266-AB XA prototype with Ecusta 5560 paper, 50% CAMEL Lts. blend with cast sheet filler containing 70% tobacco and 30% charcoal. QC prototype with Ecusta 5505 paper (30% CacO3, 11% magnesium hydroxide, 6% KCl, 6% potassium malate, 2 malic acid, and 2.5% irritation reducer) and CAMEL Lts. 85 blend. CT02119-AD Products will be smoked at a rate of 10 per hour from 9:00 am until 11:30 an. Chambers will be set at four air changes per hour on the day before testing. Products will be conditioned prior to testing. Testing Methodology: Panel: PETS VISITOR TESTING OF TBC ETS FROM SMOKING MACH. (DESCRIP) Total Resources Required: 96.00 man hours . Amount used so far: 10.00 man hours ai rey ~ Ss ow ND W ~ ts]
Document type: Memo

PHILIP MORRIS COMPANIES INC. INTER-OFFICE CORRESPONDENCE 120 PARK AVENUE, NEW YORK, N.Y. 10017 TO: RECORDS COORDINATORS AND DATE: July 28, 1994 INFORMATION SYSTEMS DEPTS.: PHILIP MORRIS COMPANIES INC., PHILIP MORRIS INCORPORATED, PHILIP MORRIS INTERNATIONAL and PHILIP MORRIS MANAGEMENT CORPORATION FROM: Charles R. Wall RE: Modification of May 4, 1994 Document Disposal Suspension Notice Requiring Retention of Electronic Mail and Other Electronic Récords in Their Original Electronic Media On May 4, 1994, the attached document disposal suspension notice (“suspension notice”) was issued as a result of a court order in pending litigation. The suspension notice required, among other things, that electronic mail and other .. electronic media be retained in their original electronic form for the categories of records described in the suspension notice. | __ ‘The court order requiring the retention of electronic media has been modified by limiting the obligation to. retain electronic records subject to the suspension notice to those written or generated on or before March 29, 1994. Effective on receipt of this memorandum, the procedure specified in the suspension notice for retaining electronic mai! and other electronic records in their original electronic form may be discontinued prospectively for those electronic records capable of being printed. From receipt of this memorandum onward, electronic mail and other electronic records, if any, should now be retained, by printing and retaining a paper copy only, in accordance with the usual retention practice for electronic records subject to each Records Management Manual’s Appendix entitled Topics Subject to Disposal Suspension. However, electronic records subject to disposal suspension that are incapable of being printed must continue to be maintained in electronic form. Except as modified in this memorandum, prior document suspension notices and the Appendix entitled Topics Subject to Disposal Suspension in each Records Management Manual remain in effect without change. 0062267PS02
Document type: Letter

~ Robinson Maites .—_—>————— Oainson. | Malis Pah he September 3, 1992 LD) ant ) Ms. Jayne K. Appleyard SJ. R. J. REYNOLDS TOBACCO COMPANY 401 North Main Street Winston-Salem, North Carolina 27102 Dear Ms. Appleyard: Enclosed is the agency's signed copy of Job Assignment Addendum No. 2021-04-00. Please note that the Estimated Compensation for the last item on the page (art & mechanicals for sleeve, coupons and POS for test) is $3,726, not $3,443. I have attached a copy of the revised fee authorization, signed by Jennifer Cc. Pierre. I'm sorry we took so long to get this back to you. Sincerely, Conde, All, | Cordier Shilling Senior Account Coordinator fi) ul YW cy: A. Maites W. A. Robinson R. Winston c. Crilly 66T2 9ZETS RJR-1t93 ROBINSON & MATEES, INC 35 bust Wacker Drive, Suite 200 Chicago, Hlinois 60601-2104 312/372-9333 FAX: 312/372-0682
Document type: Email

From: Hook, Twyna To: Smith, Jan Fulton; Carter, Peggy C.; Spainhour, Sheryl F. ce: BCC: Primary Date: 8/26/1996 1:54:00 PM Last Modified Date: 2001-Nov-20 11:08:48 Last Touched Date: Sent Date: 1996-Aug-26 13:54:00 Received Date: 1996-Aug-26 13:54:00 Subject: _xganvencuannaennannn nen in nunen sees aa SR pn R ARAMA EASA SHASEAAASA BARNA RGSS APAUARUA AUN NAUSEA USUAL UUAUA MASUR UST SAAR DNR Attachments: 08-23.D0C RJRO000000507 166148 70057 2356 sess 9b0esS
Document type: Memo

Tée From: Seoject: ae 4 dé PHILIP MORRIS U.S.A. INTER-OFFICE CORRESPONDENCE RICHMOND, VIRGINIA * PM USA Records Coordinators Date: May 5, 1994 * Lewis Cummings * DOCUMENT DISPOSAL SUSPENSION NOTICE The Legal Departzent has asked me to distribute the attached Document Disposal Suspension Notice to all PM USA Records Coordinators. The disposal of all records relating to the manufacturing, testing and composition of tobacco, tobacco products, paper, filter or any other material contained in, relating to or used in the manufacture, testing and composition of tobacco products relating to the nicotine content of tobacco, tobacco products (cigarettes, filler, reconstituted tobacco, expanded tobacco, etc.) and cigarette smoke is suspended. Please assure these records, as well as those outlined in Appendix A of the Records Management Manual, are not disposed and are retained in their original form recardless of the medium (i.e., paper, E-Mail, electronic, magnetic, microfilm, etc.). Twill notify you upon the release of any of these records from disposal suspension. If you have questions, please let me know. Attachment ec: C. C. Purcell K. W. VandensSroek FILE: P0581 ESTE Gav a0e