Document type: Resume

PRINCIPAL (INVESTIGATOR /PROGRAM DIRECTOR: BIOGRAPHICAL SKETCH Give the following information for key professional personnel listed on page 2, beginning with the Principal Investigator/Program Director, Photocopy this page for each person. TITLE Professor of Biochemistry Member, The Cancer Center EDUCATION (Begin with baccalaureate or other initial professional education and include postdoctoral training) DEGREE (circle YEAR highest degree) CONFERREO NAME Louise T. Chow 9/30/43 INSTITUTION AND LOCATION ty T965 cultural Chem. California Institute of Technology 1973 Chemistry Univ. of CA, San Francisco Med. Ctr. 1/73-7/74 w. H. Goodman California Institute of Technology 8/74-2/75 w. N. Davidson BIRTHDATE [Mo., Day, Yr.) FIELO OF STUDY RESEARCH AND/OR PROFESSIONAL EXPERIENCE: Concluding with present position, list in chronological order previous employment, experi- ence, and honors. Include present membership on any Federat Government Public Advisory Committee. List, in chronological order, the titles and complete references to ell publications during the past three years and to representative earlier publications pertinent to this application. DO NOT EXCEED TWO PAGES. Cold Spring Harbor Laboratory: Research Fellow, 2/75-2/76; Staff Investigator, 3/76-6/77; Senior Staff Investigator, 7/77-6/79; Senior Scientist, 7/79-7/84. University of Rochester School of Medicine, Associate Professor of Biochemistry and Member of the Cancer Center, 8/84-2/89; Professor of Biochemistry & Oncology, 3/89-present. Virology Study Section, NIH, 1985-1989; 1989-93 NIH Reviewers Reserve. Assoc. Editor, Virology, 1991- ; ASM Foundation for Microbiology Lecturer, 1990-91. PUBLICATIONS: 23 additional on Thomas Broker's c.v. and 35 others not listed. Chow, L.T., J.M. Roberts, J.B. Lewis and T.R. Broker. 1977. A cytoplasmic RNA transcript map of adenovirus-2 determined by electron microscopy of RNA:DNA hybrids. Cell 11: 819-836. Chow, L.T., R.E. Gelinas, T.R. Broker and RJ. Roberts. 1977. An amazing sequence arrangement at the 5° ends of adenovirus-2 messenger RNA. Cell 12: 1-8. Kamp, D., R. Kahmann, D. Zipser, T.R. Broker and L.T. Chow. 1978. Infectivity of phage Mu depends on the orientation of the invertible G DNA segment. Nature 271: 577-580. Dunn, A., M.B. Mathews, L.T. Chow, J. Sambrook and W. Keller. 1978. A supplementary adenoviral leader sequence and its role in messenger translation. Cell 15; 511-526. Chow, L.T., T.R. Broker and J.B. Lewis. 1979. Complex splicing patterns of RNA from the early regions of adenovirus-2. J. Mol. Biol. 134: 265-304. Broker, T.R., and L.T. Chow. 1979. Alternative RNA splicing patterns and the clustered transcription and splicing signals of human adenovirus-2. UCLA Symp. 14: 611-637. Klessig, D.F. and L-T. Chow. 1980. Incomplete splicing and deficient accumulation of the fiber messenger RNA in monkey cells infected by human adenovirus type 2. J. Mol. Biol. 139: 221-242. Stillman, B.W., J.B. Lewis, L.T. Chow, M.B. Mathews and J.E. Smart. 1981. Identification of the gene and mRNA for the adenovirus terminal protein precursor. Cell 23: 497-508. Chow, LT. and T.R. Broker. 1981. Electron microscopic mapping of RNA:DNA heteroduplexes. In, Electron Microscopy in Biology, Vol. 1, ed. J.D. Griffith. John Wiley and Sons, N.Y. pp. 139-188. Cowan, NJ., C.D. Wilde, L.T. Chow and F.C. Wefald. 1981. Structural variation among human beta-tubulin genes. Proc, Natl. Acad. Sci. USA 78: 4877-4881, Wilde, C.D., L.T. Chow, F.C, Wefald, and NJ. Cowan. 1982. Structures of two human alpha-tubulin genes. Proc. Natl. Acad. Sci., USA 79: 96-100, Broker, T.R. and L.T. Chow. 1981. Visualization of the adenovirus DNA terminal protein, its gene, and messenger RNA. Proc. Electron Microscopy Soc. Amer. 39: 658-661. Lopata, M.A., J.C. Havercroft, L.T. Chow and D.W. Cleveland. 1983. Four unique genes required for beta-tubulin expression in vertebrates. Cell 32: 713-724. Chow, L.T. and T.R. Broker. 1984. Human papilloma virus type 1 RNA transcription and processing in COS-1 celts. Prog. Cancer Res. Therapy 30: 125-134. Kurkinen, M., M.P. Bernard, D.P. Barlow and L.T. Chow. 1985. Characterization of 64-, 123- and 182-base-pair exons in the mouse alpha2(IV) collagen gene. Nature 317: 177-179. Soininen, R., L. Tikka, L-T. Chow, T. Pihlajaniemi, M. Kurkinen, D.J. Prockop, C.D. Boyd and K. Tryggvason. 1986. Large introns in the 3’ end of the gene for the pro-alphai(IV) chain of human basement membrane PHS 398 (Rev. 5/82) PAGE___ 50296092