anand-s/m_qalm huggingface dataset:
Question: What part of what body organ controls the circadian clock?
Answer: the suprachiasmatic nucleus (SCN) of the hypothalamus acts as the central clock in mammals, the circadian expression of clock genes
Question: What part of what body organ controls the circadian clock?
Answer: The mammalian circadian system is composed of a hierarchical multi-oscillator structure, with the central clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus in the brain
Question: Which database is available for the identification of chorion proteins in Lepidopteran proteomes?
Answer: LepChorionDB
Question: Where is the protein Pannexin1 located?
Answer: The protein Pannexin1 is localized to the plasma membranes.
Question: What is the normal function p53?
Answer: Wild-type p53 can suppress tumour development by multiple pathways.
Question: Treprostinil is an analogue for which prostaglandin?
Answer: Treprostinil is a prostaglandin I(2) (PGI(2)) analog.
Question: Which biomarker is widely used in the diagnosis of Ewing sarcoma?
Answer: CD99 is a hallmark marker for Ewing sarcoma and primitive neuroectodermal tumors.
Question: Which cellular function is associated with transcription factors forkhead 1 and 2 (Fkh1 and Fkh2)?
Answer: Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae. Here we show that the yeast Forkhead transcription factors, Fkh1 and Fkh2, are global determinants of replication origin timing. Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan. Fkh1 and Fkh2 bind Fkh-activated origins, and interact physically with ORC, providing a plausible mechanism to cluster origins. Instead, we show that Fkh1 and Fkh2 are required for the clustering of early origins and their association with the key initiation factor Cdc45 in G1 phase, suggesting that Fkh1 and Fkh2 selectively recruit origins to emergent replication factories.
Question: Which cellular function is associated with transcription factors forkhead 1 and 2 (Fkh1 and Fkh2)?
Answer: Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae. Fkh1 and Fkh2 are required for the clustering of early origins and their association with the key initiation factor Cdc45 in G1 phase. Fkh1 and Fkh2 selectively recruit origins to emergent replication factories. They both bind Fkh-activated origins, and interact physically with ORC, providing a plausible mechanism to cluster origins.
Question: Which cellular function is associated with transcription factors forkhead 1 and 2 (Fkh1 and Fkh2)?
Answer: Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae. Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan. Fkh1 and Fkh2 bind Fkh-activated origins, and interact physically with ORC, providing a plausible mechanism to cluster origins. Here we describe the remaining two genes, fhl1 and fkh2, that code for proteins containing fork-head-associated domains (FHA) besides their FKHs. This may reflect a general feature of gene regulation in eukaryotes.
Question: Which cellular function is associated with transcription factors forkhead 1 and 2 (Fkh1 and Fkh2)?
Answer: Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae.
Question: Which cellular function is associated with transcription factors forkhead 1 and 2 (Fkh1 and Fkh2)?
Answer: Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae. Here we show that the yeast Forkhead transcription factors, Fkh1 and Fkh2, are global determinants of replication origin timing. Fkh1 and Fkh2 bind Fkh-activated origins, and interact physically with ORC, providing a plausible mechanism to cluster origins. Instead, we show that Fkh1 and Fkh2 are required for the clustering of early origins and their association with the key initiation factor Cdc45 in G1 phase, suggesting that Fkh1 and Fkh2 selectively recruit origins to emergent replication factories. Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan.
Question: Which cellular function is associated with transcription factors forkhead 1 and 2 (Fkh1 and Fkh2)?
Answer: Instead, we show that Fkh1 and Fkh2 are required for the clustering of early origins and their association with the key initiation factor Cdc45 in G1 phase, suggesting that Fkh1 and Fkh2 selectively recruit origins to emergent replication factories. Fkh1 and Fkh2 bind Fkh-activated origins, and interact physically with ORC, providing a plausible mechanism to cluster origins. Here we show that the yeast Forkhead transcription factors, Fkh1 and Fkh2, are global determinants of replication origin timing.
Question: Which cellular function is associated with transcription factors forkhead 1 and 2 (Fkh1 and Fkh2)?
Answer: Here we show that the yeast Forkhead transcription factors, Fkh1 and Fkh2, are global determinants of replication origin timing. Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan.
Question: Which cellular function is associated with transcription factors forkhead 1 and 2 (Fkh1 and Fkh2)?
Answer: Forkhead transcription factors establish origin timing and long-range clustering in S. cerevisiae. Here we show that the yeast Forkhead transcription factors, Fkh1 and Fkh2, are global determinants of replication origin timing.
Question: How many genes are screened by the FoundationOne companion diagnostic?
Answer: FoundationOne CDx comprises a 324-gene panel.
Question: Which cells secretes alpha defensin 5?
Answer: Human enteric α-defensins (HD5 and HD6), major antimicrobial peptides produced by Paneth cells in the intestine, play important roles in intestinal innate immunity.
Question: What is the frequency of mutations induced spontaneously through Ethylnitrosourea (ENU) mutagenesis?
Answer: Theoretical considerations and empirical analysis suggest that the per-base mutation frequency for a fractionated-dose treatment protocol is on the order of 1 sequence change per 10(5) bp.
Question: What type of mutation is causing the industrial melanism phenotype in peppered moths?
Answer: The mutation event giving rise to industrial melanism in Britain was the insertion of a large, tandemly repeated, transposable element into the first intron of the gene cortex.
Question: Approximately how many genes are contained in the X chromosome's non-pseudoautosomal region (non-PAR)?
Answer: The total number of genes contained in the X chromosome's non- pseudoautosomal region (PAR) is 783.
Question: Approximately how many genes are contained in the X chromosome's non-pseudoautosomal region (non-PAR)?
Answer: There are 783 non-pseudoautosomal region (PAR) X-chromosome genes.
Question: Approximately how many genes are contained in the X chromosome's non-pseudoautosomal region (non-PAR)?
Answer: Six of 783 non-pseudoautosomal region (PAR) X-chromosome genes harbored loss-of-function mutations more frequently in males.
Question: Approximately how many genes are contained in the X chromosome's non-pseudoautosomal region (non-PAR)?
Answer: There are 783 non-pseudoautosomal region X-chromosome genes harbored loss-of-function mutations more frequently in males.
Question: Approximately how many genes are contained in the X chromosome's non-pseudoautosomal region (non-PAR)?
Answer: The number of genes contained in the X chromosome's non-pseudoautosomal region (non-PAR) is 783.
Question: Approximately how many genes are contained in the X chromosome's non-pseudoautosomal region (non-PAR)?
Answer: The number of genes contained in the non- pseudo-autosomal region (PAR) X chromosome is 783.
Question: What disease is associate with defects in both the KDM6A (lysine specific demethylase 6A) and KMT2D (lysine methyltransferase 2D)
Answer: Over the last 20 years, mutations in five key COMPASS complex genes have been linked to three human congenital syndromes: Kabuki syndrome (type 1 [KMT2D] and 2 [KDM6A]
Question: What disease is associate with defects in both the KDM6A (lysine specific demethylase 6A) and KMT2D (lysine methyltransferase 2D)
Answer: Kabuki syndrome is a rare genetic disorder, caused by mutation in the KMT2D or KDM6A genes, which affects several organs in the majority of patients, among which are the eyes.
Question: Which receptor is inhibited by bimagrumab?
Answer: Bimagrumab is a fully human monoclonal antibody that blocks the activin type II receptors, preventing the activity of myostatin and other negative skeletal muscle regulators.
Question: Which type of sarcoma has been associated with members of the oral microbiome?
Answer: Alterations in the oral microbiota in the immunosuppressed population may be associated with diseases such as Kaposi's sarcoma.
Question: What is the meaning of the acronym "TAILS" used in protein N-terminomics?
Answer: TAILS stands for "Terminal Amine Isotopic Labeling of Substrates"
Question: Which is the cellular target of gefitinib?
Answer: The specific cellular target of Gefitinib (Iressa) is the epidermal growth factor receptor (EGFR).
Question: What is the first line treatment for sarcoidosis?
Answer: Sarcoidosis is a systemic granulomatous disease that affects numerous organs, commonly manifesting at the lungs and skin. Corticosteroids remain the first line of treatment.
Question: Which complex is bound by estrogen-related receptor β (Esrrb)?
Answer: Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells.
Question: Which complex is bound by estrogen-related receptor β (Esrrb)?
Answer: Knockdown of Mp1 redirected FGF4 signaling from differentiation toward pluripotency and up-regulated the pluripotency-related genes Esrrb, Rex1, Tcl1, and Sox2. Dax1 associates with Esrrb and regulates its function in embryonic stem cells. Here, we identified an orphan nuclear receptor, Esrrb (estrogen-related receptor beta), as a Dax1-interacting protein.
Question: What is plantar fasciitis
Answer: Plantar fascia (PF) disorders like plantar fasciitis commonly cause heel pain and disability and are thought to be degenerative rather than inflammatory in nature
Question: Which enzyme is inhibited by Imetelstat?
Answer: Imetelstat works by inhibiting telomerase.
Question: Which human tissue synthesize CRP?
Answer: CRP is predominantly produced in the liver in a native pentameric form (nCRP).
Question: How many proteins have been queried for protein partners by the Drosophila protein interaction map (DPiM)?
Answer: Over 5,000 proteins have been queried for protein partners by the Drosophila protein interaction map (DPiM).
Question: How many proteins have been queried for protein partners by the Drosophila protein interaction map (DPiM)?
Answer: 5,000 proteins have been queried for protein partners by the Drosophila protein interaction map (DPiM).
Question: How many proteins have been queried for protein partners by the Drosophila protein interaction map (DPiM)?
Answer: Defining protein-protein interactions in protein complexes, and establishing the when, what and where of potential interactions, is crucial to understanding the cellular function of any protein-especially those that have not been well studied by traditional molecular genetic approaches. In the Drosophila protein interaction map (DPiM) protein partners of nearly 5,000 Drosophila melanogaster proteins have been identified.
Question: Which drug should be used as an antidote in benzodiazepine overdose?
Answer: Flumazenil should be used in all patients presenting with suspected benzodiazepine overdose. Flumazenil is a  potent benzodiazepine receptor antagonist that competitively blocks the central effects of benzodiazepines and reverses behavioral, neurologic, and electrophysiologic effects of benzodiazepine overdose. Clinical efficacy and safety of flumazenil in treatment of benzodiazepine overdose has been confirmed in a number of rigorous clinical trials. In addition, flumazenil is also useful to to reverse benzodiazepine induced sedation and to and to diagnose benzodiazepine overdose.
Question: Which is the largest metabolic gene cluster in yeast?
Answer: The DAL cluster is the largest metabolic gene cluster in yeast and consists of six adjacent genes encoding proteins that enable Saccharomyces cerevisiae to use allantoin as a nitrogen source.
Question: Which is the largest metabolic gene cluster in yeast?
Answer: the dal cluster is the largest metabolic gene cluster in yeast and consists of six adjacent genes encoding proteins that enable saccharomyces cerevisiae to use allantoin as a nitrogen source.
Question: Which is the largest metabolic gene cluster in yeast?
Answer: The DAL cluster is the largest metabolic gene cluster in yeast and consists of six adjacent genes encoding proteins that enable Saccharomyces cerevisiae to use allantoin as a nitrogen source. The DAL cluster is located in a domain of modified chromatin involving both H2A.Z histone exchange and Hst1-Sum1-mediated histone deacetylation, and it may be a coadapted gene complex formed by epistatic selection.
Question: Which is the largest metabolic gene cluster in yeast?
Answer: The DAL cluster is the largest metabolic gene cluster in yeast and consists of six adjacent genes encoding proteins that enable Saccharomyces cerevisiae to use allantoin as a nitrogen source. Six of the eight genes involved in allantoin degradation, which were previously scattered around the genome, became relocated to a single subtelomeric site in an ancestor of S. cerevisiae and Saccharomyces castellii.
Question: What is the indication for zolmitriptan?
Answer: Development of a novel zolmitriptan intracutaneous microneedle system (Qtrypta™) for the acute treatment of migraine
Question: What is the indication for zolmitriptan?
Answer: Zolmitriptan is an effective medicine used in the treatment of migraine.
Question: What is the indication for zolmitriptan?
Answer: zolmitriptan is approved for the treatment of migraine.
Question: What is the indication for zolmitriptan?
Answer: zolmitriptan is approved for migraine treatment.
Question: What are common variants at 12q14 and 12q24 associated with?
Answer: Common variants at 12q14 and 12q24 are associated with hippocampal volume. Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors.
Question: What are common variants at 12q14 and 12q24 associated with?
Answer: Common variants at 12q14 and 12q24 are associated with hippocampal volume. As we age, our hippocampus (the part of the brain that is responsible for memory and cognition) becomes less and less efficient at storing information. As a result, the volume of the hippocampus shrinks.
Question: What are common variants at 12q14 and 12q24 associated with?
Answer: Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Question: What are common variants at 12q14 and 12q24 associated with?
Answer: Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Common variants at 12q14 and 12q24 are associated with hippocampal volume.
Question: What is situs inversus?
Answer: Situs inversus totalis is a rare congenital anomaly with a complete mirror image of the thoracic and abdominal organs.
Question: What is the presumed key event in Fanconi anemia pathogenesis?
Answer: Monoubiquitination of the Fanconi anaemia protein FANCD2 is a key event leading to repair of interstrand cross-links. Failure of FANCD2 monoubiquitination by the nuclear FA protein complex has a severe impact on the DNA repair functions of cells.
Question: Where is the metaxin complex localized?
Answer: The metaxin complex is localized to the outer mitochondrial membrane.
Question: Falciform ligament sign is characteristic to which disease?
Answer: The falciform ligament sign (gas outlining the falciform ligament) is characteristic to pneumoperitoneum due to intestinal perforation.
Question: Which protein pathway is regulating SGK1-mediated phosphorylation of FOXO3a to control cell proliferation?
Answer: mTORC1, in coordination with mTORC2, controls cell proliferation by regulating FoxO3a gene expression and SGK1-mediated phosphorylation of FOXO3a at Ser314.
Question: Which infection can be prevented with Dapivirine?
Answer: Vaginal ring containing Dapivirine is used for HIV prevention in women.
Question: What is the chromosomal abnormality associated with Klinefelter Syndrome
Answer: About 1 in 650 boys are born with an extra X chromosome (47,XXY or Klinefelter syndrome). 47,XXY
Question: What is the chromosomal abnormality associated with Klinefelter Syndrome
Answer: About 1 in 650 boys are born with an extra X chromosome (47,XXY or Klinefelter syndrome)
Question: What tissue is most affected in Ehlers-Danlos syndromes?
Answer: the ehlers-danlos syndromes (eds) are a group of connective tissue disorders characterized by triad of joint hypermobility, skin extensibility, and tissue fragility.
Question: What tissue is most affected in Ehlers-Danlos syndromes?
Answer: The Ehlers-Danlos syndromes (EDS) are a group of connective tissue disorders characterized by triad of joint hypermobility, skin extensibility, and tissue fragility.
Question: Which algorithm has been developed for prediction of protein subcellular localization using deep learning?
Answer: DeepLoc is an algorithm which has been developed for prediction of protein subcellular localization using deep learning.
Question: What is commotio cordis?
Answer: Commotio cordis is a term used to describe cases of blunt thoracic impact causing sudden death without structural damage of the heart
Question: DX-88 is investigational name of which drug?
Answer: DX-88 is investigational name of a drug Ecallantide, a 60-amino acid recombinant protein discovered through phage display technology, that is a highly specific, potent inhibitor of human plasma kallikrein that has been used successfully in the treatment of patients experiencing acute hereditary angioedema attacks.
Question: Which DNA repair system is involved in HNPCC?
Answer: In HNPCC families, germline mutations in any of four genes encoding proteins of a specialized DNA repair system, the mismatch repair, predispose to cancer development.
Question: Inhaled Molgramostim can be used for treatment of which disease?
Answer: Inhaled Molgramostim was shown to be effective for Autoimmune Pulmonary Alveolar Proteinosis.
Question: What chromosome is affected in Turner's syndrome?
Answer: Turner's syndrome (TS) is a chromosomal defect with partial or total absence of the X chromosome.
Question: What chromosome is affected in Turner's syndrome?
Answer: turner's syndrome (ts) is a chromosomal defect with partial or total absence of the x chromosome.
Question: What chromosome is affected in Turner's syndrome?
Answer: Turner's syndrome (TS) is a chromosomal defect with partial or total absence of the X chromosome
Question: What organism causes hepatic capillariasis?
Answer: Hepatic capillariasis is a rare and neglected parasitic disease caused by infection with Capillaria hepatica in human liver.
Question: What organism causes hepatic capillariasis?
Answer: hepatic capillariasis, caused by the parasite Capillaria hepatica,
Question: What is a GPI anchor?
Answer: Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved posttranslational modification in the endoplasmic reticulum (ER). 	Glycosylphosphatidylinositols (GPIs) are lipid anchors allowing the exposure of proteins at the outer layer of the plasma membrane.
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: The Notch/Hes axis represses a cohort of transcription factor genes . In Drosophila, activation of the Notch receptor induces transcriptional repressors encoded by the hairy/Enhancer of split (HES) genes, which shut off achaete-scute transcription . The molecular details of how Hes and Hey proteins control transcription are still poorly understood .
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: Hes genes encode factors that mediate many of the activities of the Notch pathway. Hes genes are functionally classified into two groups: those that are regulated by Notch and those that are not.
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: Mammalian Hes genes encode transcriptional factors that mediate many of the activities of the Notch pathway. HES transcriptional repressors are important components of the Notch pathway that regulates neurogenesis from Drosophila to vertebrates.
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: In Drosophila, activation of the Notch receptor induces transcriptional repressors encoded by the hairy/Enhancer of split (HES) genes, which interact with the Groucho protein to shut off achaete-scute transcription.
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. Mammalian Hes genes encode transcriptional factors that mediate many of the activities of the Notch pathway.
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: HES transcriptional repressors are important components of the Notch pathway that regulates neurogenesis from Drosophila to vertebrates. Hes genes are responsible for co-ordinating the Notch response of a wide spectrum of other targets, explaining the critical functions these key regulators play in many developmental and disease contexts. Hes1, Hes5, and Hes7 are known as downstream effectors of canonical Notch signaling, which regulates cell differentiation via cell-cell interaction
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: The Notch/Hes axis represses a cohort of transcription factor genes . The molecular details of how Hes and Hey proteins control transcription are still poorly understood . In Drosophila, activation of the Notch receptor induces transcriptional repressors encoded by the hairy/Enhancer of split (HES) genes, which act as negative regulators in this process .
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. Hes1, Hes5, and Hes7 are known as downstream effectors of canonical Notch signaling, which regulates cell differentiation via cell-cell interaction
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. Based on these data, we propose a model in which Hes genes are responsible for co-ordinating the Notch response of a wide spectrum of other targets, explaining the critical functions these key regulators play in many developmental and disease contexts.
Question: Which transcription factor controls Drosophila's Hes genes?
Answer: Mammalian Hes genes encode transcriptional factors that mediate many of the activities of the Notch pathway . Hes1, Hes5, and Hes7 are known as downstream effectors of canonical Notch signaling . The Notch-Hes1 pathway regulates ovarian somatic cell development, which is necessary for oocyte survival and maturation .
Question: What is the effect of the direct interaction of Ikaros and Foxp1 in B-lymphocytes?
Answer: Direct interaction of Ikaros and Foxp1 modulates expression of the G protein-coupled receptor G2A in B-lymphocytes and acute lymphoblastic leukemia.
Question: What is the effect of the direct interaction of Ikaros and Foxp1 in B-lymphocytes?
Answer: The effect of the direct interaction of Ikaros and Foxp1 in B-lymphocytesis is modulation of expression of the G protein-coupled receptor G2A.