anand-s/m_qalm huggingface dataset:
Question: Which species is the carrier of the SFTS ( severe fever with thrombocytopenia syndrome) virus?
Answer: The possibility that SFTSV transmission may occur by both the transstadial and transovarial routes was suggested by the fact that viral RNA was detected in Haemaphysalis longicornis at all developmental stages. Tick-derived sequences shared over 95.6% identity with human- and animal-derived isolates. This study provides evidence that implicates ticks as not only vectors but also, reservoirs of SFTSV.
Question: Which species is the carrier of the SFTS ( severe fever with thrombocytopenia syndrome) virus?
Answer: Seroprevalence in animal species were: goats (66.8%), cattle (28.2%), dogs (7.4%), pigs (4.7%), chickens (1.2%), geese (1.7%), rodents (4.4%) and hedgehogs (2.7%). The possibility that SFTSV transmission may occur by both the transstadial and transovarial routes was suggested by the fact that viral RNA was detected in H. longicornis at all developmental stages. Tick-derived sequences shared over 95.6% identity with human- and animal-derived isolates.
Question: Which species is the carrier of the SFTS ( severe fever with thrombocytopenia syndrome) virus?
Answer: The possibility that SFTSV transmission may occur by both the transstadial and transovarial routes was suggested by the fact that viral RNA was detected in H. longicornis at all developmental stages. Severe fever with thrombocytopenia syndrome (SFTS) is a new emerging zoonosis.
Question: Which disease is treated with lucinactant?
Answer: Lucinactant us used for the prevention of respiratory distress syndrome in premature infants.
Question: Which method is available for whole genome identification of pathogenic regulatory variants in mendelian disease?
Answer: Genomiser
Question: What organism causes Rhombencephalitis?
Answer: Rhombencephalitis caused by Listeria monocytogenes
Question: What organism causes Rhombencephalitis?
Answer: Rhombencephalitis is caused by Listeria monocytogenes
Question: Which R package is used for the detection of chromosomal abnormalities from microarray data?
Answer: CAFE is an R package for the detection of gross chromosomal abnormalities from gene expression microarray data.
Question: What is the function of LOX proteins in the ECM?
Answer: Lysyl oxidases (LOX) are copper-dependent enzymes that oxidize primary amine substrates to reactive aldehydes. The best-studied role of LOX enzymes is the remodeling of the extracellular matrix (ECM) in animals by cross-linking collagens and elastin
Question: Which syndrome is caused by deletion of Pds5b in mice?
Answer: Mice lacking sister chromatid cohesion protein Pds5b exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.
Question: Which syndrome is caused by deletion of Pds5b in mice?
Answer: Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.
Question: Which syndrome is caused by deletion of Pds5b in mice?
Answer: Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome
Question: Which syndrome is caused by deletion of Pds5b in mice?
Answer: mice lacking sister chromatid cohesion protein pds5b exhibit developmental abnormalities reminiscent of cornelia de lange syndrome.
Question: What is the function of Plasminogen activator inhibitor 1?
Answer: Plasminogen activator inhibitor-1 (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and plays a critical role in fibrinolysis.
Question: What is the target of the drug Olmesartan?
Answer: Olmesartan (OL) is the pharmacologically active metabolite of Olmesartan medoxomil (OM), an FDA-approved angiotensin II receptor antagonist for administrating cardiovascular diseases
Question: What is the target of Volanesorsen?
Answer: Volanesorsen is a second-generation antisense oligonucleotide inhibiting apoC-III (apolipoprotein C-III) transcription/translation that has been recently approved in Europe for Familial Chylomicronemia Syndrome (FCS) treatment.
Question: What receptor is associated with the protein encoded by the Spätzle gene?
Answer: Currently, as a ligand for the Toll-1 receptor, only Spatzle (Spz) has been identified and characterized.
Question: What receptor is associated with the protein encoded by the Spätzle gene?
Answer: Currently Spatzle (Spz) has been identified and characterized as a ligand for the Toll-1 receptor
Question: What receptor is associated with the protein encoded by the Spätzle gene?
Answer: Spatzle (Spz) is the toll-1 receptor gene encoding a protein subunit of a multisubunit membrane protein complex that plays a central role in the remodeling of the cytoskeleton and its association with the membrane.
Question: What receptor is associated with the protein encoded by the Spätzle gene?
Answer: The  Drosophila  Toll-1 receptor is involved in embryonic development, innate immunity, and tissue homeostasis. Currently, as a ligand for the  Toll-1 receptor, only  Spatzle ( Spz) has been identified and characterized.
Question: HER-2 belongs to what family of proteins?
Answer: Her-2 belongs to the family of the human epidermal growth factor receptors (EGFRs).
Question: HER-2 belongs to what family of proteins?
Answer: HER-2 belongs to the human epidermal growth factor receptor family, which is a family of proteins that also includes EGF, EGF1, HER3, HER4, HER5, and HER6.
Question: HER-2 belongs to what family of proteins?
Answer: HER-2 belongs to the human epidermal growth factor receptor family, which is a family of proteins that also includes EGF, EGF1, HER2, HER3, HER4, HER5, HER6, and HER8.
Question: HER-2 belongs to what family of proteins?
Answer: HER-2 belongs to the human epidermal growth factor receptor family, which is a family of proteins that also includes EGF, EGF1, HER2, HER3, HER4, HER5, and HER6.
Question: HER-2 belongs to what family of proteins?
Answer: HER-2 belongs to the human epidermal growth factor receptor family, which is a family of proteins that also includes EGF, EGF1, HER2, HER3, HER4, HER5, HER6, HER7, HER8, and HER9.
Question: HER-2 belongs to what family of proteins?
Answer: HER-2 is also known as human epidermal growth factor receptor 2 and is a member of the Epidermal growth factor receptor (EGFR) family, members of which are: EGFR, HER2, HER3, and HER4.
Question: HER-2 belongs to what family of proteins?
Answer: HER-2 belongs to the human epidermal growth factor receptor family, which is a family of proteins that also includes EGF, EGF1, HER2, HER3, HER4, HER5, HER6, HER7, and HER8.
Question: HER-2 belongs to what family of proteins?
Answer: Her-2 belongs to the human epidermal growth factor receptor 2 (EGF) family of proteins.
Question: HER-2 belongs to what family of proteins?
Answer: Herceptin-2 belongs to the human epidermal growth factor receptor 2 (HER2) family of proteins.
Question: What does the human ABCC gene  product do?
Answer: The important drug resistance-conferring members belong to three subfamilies of the human ABC family; these are ABCB1 (MDR1/P-glycoprotein of subfamily ABCB), subfamily ABCC (MRPs), and ABCG2 (BCRP of subfamily ABCG), which are expressed in various organs. The ATP-binding cassette (ABC) transporters constitute a large family of membrane proteins, which transport a variety of compounds through the membrane against a concentration gradient at the cost of ATP hydrolysis
Question: What is targeted by monoclonal antibody Pembrolizumab?
Answer: Pembrolizumab inhibits the programmed cell death 1 (PD-1) immune checkpoint and has antitumor activity in patients with advanced melanoma. Pembrolizumab is approved by the US Food and Drug Administration for the treatment of advanced melanoma, and additional regulatory approvals are expected across the oncologic spectrum for a variety of other agents that target these pathways.
Question: How many TAp73 isoforms have been identified in humans?
Answer: The TP73 gene, due to the presence of two promoters (P1 and P2) in its 5' flanking region, encodes a fully transcriptionally active domain (TAp73) and the amino terminus deleted (ΔNp73). TAp73 possesses pro-apoptotic properties, while deltaNp73 has anti-apoptotic functions. Alternative 3'-end splicing results in generation of at least seven TAp73 distinctive isoforms ( α, β, γ, etc ).
Question: How many TAp73 isoforms have been identified in humans?
Answer: The Trp73 gene belongs to the p53 family of transcription factors and, like the other members, is transcribed into different isoforms [1-4]. TP73 gene contains two promoters, encoding the transcriptional domain-containing (TAp73) and the amino deleted (DNp73) isoforms [5, 6]. Furthermore alternative splicing at the 3'-end (to generate a, b, g, etc isoforms) and 5'-end (to generate D2, D3 and D2-3 isoforms) results in generation of at least 14 different transcripts, with different abilities to promote or repress apoptosis [7, 8]. (PMID: 22388545)
Question: A herd immunity of what percentage of the population is required to prevent sporadic outbreaks?
Answer: A herd immunity of 95% of the population is required to prevent sporadic outbreaks.
Question: What is the mode of administration of AZD8601?
Answer: AZD8601 is administered intradermally.
Question: Which JAK (Janus kinase) inhibitor is approved for treatment of rheumatoid arthritis?
Answer: Tofacitinib (or CP690.550) is an oral JAK (Janus kinase) inhibitor that is approved for treatment of rheumatoid arthritis. Tofacitinib inhibits JAK family kinase members, in particular JAK1 and JAK3, achieving a broad limitation of inflammation by interfering with several cytokine receptors. Tofacitinib has also a proven efficacy as an immunosuppressive regimen after renal transplantation.  
GLPG-0634 and INCB18424 are other JAK kinase inhibitors that are being studied for treatment of rheumatoid arthritis.
Question: What is the SLC25A20 protein transporting?
Answer: The carnitine/acylcarnitine transporter (CACT; SLC25A20) mediates an antiport reaction allowing entry of acyl moieties in the form of acylcarnitines into the mitochondrial matrix and exit of free carnitine.
Question: What is the method FASP used for?
Answer: Filter Aided Sample Preparation (FASP), a type of proteomic reactor, in which samples dissolved in sodium dodecyl sulfate (SDS) are digested in an ultrafiltration unit.
Question: How many different miRNAs can be upregulated by LB-100?
Answer: LB-100 has been reported to upregulate one miRNA, namely miR-181b-1.
Question: PDQ39 questionnaires is design for which disease?
Answer: PDQ39 is Parkinson's Disease Questionnaire that is used for assessment of quality of life in patients with Parkinson's Disease.
Question: What is the preferred orientation of CTCF binding sites for chromatin looping?
Answer: chromatin loops preferentially form between CTCF binding sites oriented in a convergent manner. CTCF sites at loop anchors occur predominantly (>90%) in a convergent orientation, with the asymmetric motifs "facing" one another.
Question: What is the preferred orientation of CTCF binding sites for chromatin looping?
Answer: As recently reported, our data also suggest that chromatin loops preferentially form between CTCF binding sites oriented in a convergent manner. Recent studies identified a correlation between the orientation of CTCF-binding sites  and chromatin loops. Recent reports have suggested that CTCF binding is more dynamic during development than previously appreciated.
Question: What is the preferred orientation of CTCF binding sites for chromatin looping?
Answer: As recently reported, our data also suggest that chromatin loops preferentially form between CTCF binding sites oriented in a convergent manner CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function.
Question: Which is the function of ubiquilins?
Answer: Ubiquilins, a family of ubiquitin-binding proteins, are involved in all protein degradation pathways. Ubiquilin (UBQLN) proteins are adaptors thought to link ubiquitinated proteins to the proteasome.
Question: What is the genetic basis of tuberous sclerosis?
Answer: The genetic basis of tuberous sclerosis has been attributed to mutations in one of two unlinked genes, TSC1 and TSC2. The functions of the TSC1 and TSC2 gene products, hamartin and tuberin, respectively, have remained ill defined until recently. Genetic, biochemical, and biologic analyses have highlighted their role as negative regulators of the mTOR signaling pathway. Tuberin, serving as a substrate of AKT and AMPK, mediates mTOR activity by coordinating inputs from growth factors and energy availability in the control of cell growth, proliferation, and survival. Emerging evidence also suggests that the TSC 1/2 complex may play a role in modulating the activity of beta-catenin and TGFbeta. These findings provide novel functional links between the TSC genes and other tumor suppressors.
Question: What is the genetic basis of tuberous sclerosis?
Answer: The genetic basis of this disease has been attributed to mutations in one of two unlinked genes, TSC1 and TSC2.
Question: What is the genetic basis of tuberous sclerosis?
Answer: We previously found TSC2 loss of heterozygosity in 7 of 13 (54%) of angiomyolipomas from sporadic LAM patients, suggesting that LAM and TSC could have a common genetic basis. In this study, we report the identification of somatic TSC2 mutations in five of seven angiomyolipomas from sporadic LAM patients. Our data demonstrate that somatic mutations in the TSC2 gene occur in the angiomyolipomas and pulmonary LAM cells of women with sporadic LAM, strongly supporting a direct role of TSC2 in the pathogenesis of this disease. The study of hereditary tumor syndromes has laid a solid foundation toward understanding the genetic basis of cancer.
Question: What can be predicted with the Wells criteria?
Answer: Wells criteria are used to determine clinical probability of pulmonary embolism.
Question: What is the sedimentation coefficient of the mammalian mitoribosome?
Answer: The mammalian mitochondrial ribosome (mitoribosome) has a highly protein-rich composition with a small sedimentation coefficient of 55 S, consisting of 39 S large and 28 S small subunits.
Question: How is bladder wall thickness measured?
Answer: Ultrasound
Question: What are 'vildagliptin', 'sitagliptin', 'saxagliptin', 'alogliptin', 'linagliptin', and 'dutogliptin'?
Answer: "Sitagliptin," "vildagliptin," "saxagliptin," "alogliptin," "linagliptin," and "dutogliptin" are dipeptidyl peptidase-4 (DPP-4) inhibitors.
Question: What is the localization of the protein encoded by the gene DNAJC11?
Answer: mitochondrial inner membrane
Question: Which R/bioconductor package utilizes the Hilbert curve in order to visualize genomic data?
Answer: The so-called Hilbert curve visualization can complement genome browsers and help to get further insights into the structure of one's data. An open-source application, called HilbertVis, has been developed for R/bioconductor that allows the user to produce and interactively explore such plots.
Question: Mention the only available genomics and developmental transcriptomics resource for the urochordate Oikopleura dioica
Answer: OikoBase (http://oikoarrays.biology.uiowa.edu/Oiko/) is a tiling array-based genome browser resource for Oikopleura dioica, a metazoan belonging to the urochordates, the closest extant group to vertebrates. OikoBase facilitates retrieval and mining of a variety of useful genomics information and will provide a valuable resource for research in chordate development, genome evolution and plasticity and the molecular ecology of this important marine planktonic organism.
Question: Which is the main calcium pump of the sarcoplasmic reticulum?
Answer: Sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) is the pump crucial for calcium homeostasis. SERCA is a membrane protein that belongs to the family of P-type ion translocating ATPases and pumps free cytosolic calcium into intracellular stores.
Question: What is the cause of Krabbe disease?
Answer: Globoid cell leukodystrophy (GLD), or Krabbe disease, is an inherited, neurologic disorder that results from deficiency of a lysosomal enzyme, galactosylceramidase.
Question: What is hyperosmia
Answer: Hyperosmia is increased olfactory acuity
Question: What is hyperosmia
Answer: increased olfactory acuity
Question: What protein complex is altered in "Coffin-Siris syndrome"?
Answer: he genes causative of CSS mainly encode the SWI/SNF complex, which contributes to chromatin remodeling and regulates the access of transcriptional factors to specific gene sites.
Question: What protein complex is altered in "Coffin-Siris syndrome"?
Answer: Report. Mutations in the BAF-Complex Subunit DPF2 Are Associated with Coffin-Siris Syndrome. Variants affecting the function of different subunits of the BAF chromatin-remodelling complex lead to various neurodevelopmental syndromes, including Coffin-Siris syndrome.
Question: Which is the neurodevelopmental disorder associated to mutations in the X- linked gene mecp2?
Answer: The neurodevelopmental disorder named Rett syndrome, originally termed as cerebroatrophic hyperammonemia. Although most exclusively affects females, has also been found in male patients.
Question: Sclerostin regulates what process?
Answer: Sclerostin plays a critical role in bone homeostasis and its deficiency or pharmacological neutralization increases bone formation
Question: Which annotated database of A-to-I RNA editing is available?
Answer: RADAR is a rigorously annotated database of A-to-I RNA editing. RADAR includes a comprehensive collection of A-to-I RNA editing sites identified in humans (Homo sapiens), mice (Mus musculus) and flies (Drosophila melanogaster), together with extensive manually curated annotations for each editing site. RADAR also includes an expandable listing of tissue-specific editing levels for each editing site, which will facilitate the assignment of biological functions to specific editing sites.
Question: Which annotated database of A-to-I RNA editing is available?
Answer: The identification of A-to-I RNA editing sites has been dramatically accelerated in the past few years by high-throughput RNA sequencing studies. RADAR includes a comprehensive collection of A-to-I RNA editing sites identified in humans (Homo sapiens), mice (Mus musculus) and flies (Drosophila melanogaster), together with extensive manually curated annotations for each editing site.
Question: What is the effect of NFIA on astrocyte differentiation?
Answer: NFIA promotes astrocyte differentiation from neural precursor cells.
Question: Which particular intersex phenotype is related to steroid reductase?
Answer: Steroid reductase mutations are associated with both sex-determining and non-syndromic hypospadias
Question: Which particular intersex phenotype is related to steroid reductase?
Answer: Virilization of the external genitalia in the male fetus requires testosterone and dihydrotestosterone (DHT), which is formed from testosterone by the action of the enzyme, 5alpha-reductase type 2 (5alphaR-2). Numerous cases of male pseudohermaphroditism due to 5 alpha reductase-2 deficiency have been identified.
Question: Which particular intersex phenotype is related to steroid reductase?
Answer: Mutations in the steroid 5 alpha-reductase 2 gene are the cause of 5 alpha reductase deficiency. In the 20 yr since it was established that impairment of dihydrotestosterone formation is a cause of a rare form of human intersex, a wealth of information has accumulated about the genetics, endocrinology, and variable phenotypic manifestations.
Question: Which particular intersex phenotype is related to steroid reductase?
Answer: Hypospadias is a rare form of intersex due to reduced activity of steroid reductase 5 alpha-reductase.
Question: Is fingolimod a drug or a pro-drug?
Answer: FTY720 is a prodrug.
Question: Where is base J found in the genome of Leishmania tarentolae?
Answer: Base J (β-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. Base J is found predominantly in repetitive DNA and correlates with epigenetic silencing of telomeric variant surface glycoprotein genes in Trypanosoma brucei.
Question: Where is base J found in the genome of Leishmania tarentolae?
Answer: Base J (-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. Base J is found predominantly in repetitive DNA and correlates with epigenetic silencing of telomeric variant surface glycoprotein genes in Trypanosoma brucei. J is enriched at sites involved in RNA polymerase (RNAP) II initiation and termination.
Question: Where is base J found in the genome of Leishmania tarentolae?
Answer: Base J (Î²-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. Base J is found predominantly in repetitive DNA and correlates with epigenetic silencing of telomeric variant surface glycoprotein genes in Trypanosoma brucei.
Question: Where is base J found in the genome of Leishmania tarentolae?
Answer: Base J (β-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops.
Question: Where is base J found in the genome of Leishmania tarentolae?
Answer: j (β-d-glucosyl-hydroxymethyluracil) replaces 1% of t in the leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. . j is found predominantly in repetitive dna and correlates with epigenetic silencing of telomeric variant surface glycoprotein genes in trypanosoma brucei. .
Question: Where is base J found in the genome of Leishmania tarentolae?
Answer: base j (β-d-glucosyl-hydroxymethyluracil) replaces 1% of t in the leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops.
Question: Which receptors does bimagrumab block?
Answer: Bimagrumab blocks the activin type II receptors.
Question: What gene is mutated in Sickle Cell Anemia?
Answer: Sickle cell anemia (SCA) is an autosomal recessive disease caused by by the HBB:c.20A>T mutation that leads to hemoglobin S synthesis.
Question: What gene is mutated in Sickle Cell Anemia?
Answer:  sca patients present clinical and hematologic variability that cannot be only explained by the single mutation in the beta-globin gene.
Question: Neurostimulation of which nucleus is used for treatment of dystonia?
Answer: Neurostimulation of globus pallidus internus is effective for treatment of dystonia. Ventral intermediate thalamic nucleus has also been tested for neurostimulation in dystonia patients.
Question: Where, in what US state, was there a measles outbreak in an Amish community
Answer: The measles outbreak started an Amish community in Ohio
Question: Which gene test can be used for the X-linked myotubular myopathy?
Answer: Genetic testing of the MTM1 gene can be used for the X-linked myotubular myopathy.
Question: What is the trade name of sildenafil?
Answer: The trade name of sildenafil is Viagra.
Question: Which is the enzyme that degrades decapped mRNAs?
Answer: The removal of the 5'-cap structure by the decapping enzyme DCP2 and its coactivator DCP1 shuts down translation and exposes the mRNA to 5'-to-3' exonucleolytic degradation by XRN1
Question: Which is the enzyme that degrades decapped mRNAs?
Answer: The removal of the 5'-cap structure by the decapping enzyme DCP2 and its coactivator DCP1 shuts down translation and exposes the mRNA to 5'-to-3' exonucleolytic degradation by XRN1.
Question: How many genes belong to the KRAB-ZNF family in the human genome?
Answer: The KRAB-ZNF family is a multisubunit protein family comprised of 70 co-regulated genes, denoted KLR1-ZNF15, that is represented by multigene families in the human genome.
Question: How many genes belong to the KRAB-ZNF family in the human genome?
Answer: There are 70 human KRAB-ZNFs.