anand-s/m_qalm huggingface dataset:
Question: What is the enzymatic activity of the breast cancer associated gene BRCA1?
Answer: E3-ubiquitin ligase activity is the only known enzymatic activity of BRCA1, which is mediated by the N-terminal RING finger domain.BRCA1 nuclear transport and ubiquitin E3 ligase enzymatic activity are tightly regulated by the BRCA1 dimeric binding partner BARD1 and further modulated by cancer mutations and diverse signaling pathways.
Question: What is the enzymatic activity of the breast cancer associated gene BRCA1?
Answer: Discovering the precise function of the breast and ovarian specific tumor suppressor, BRCA1, has proven to be quite complicated. The protein encoded by BRCA1 interacts in vivo with the related BARD1 protein to form a heterodimeric complex that acts as a ubiquitin E3 ligase. E3-ubiquitin ligase activity is the only known enzymatic activity of BRCA1, which is mediated by the N-terminal RING finger domain.
Question: What kind of mutations cause GRK1 associated Oguchi disease?
Answer: Biallelic mutations in G-Protein coupled receptor kinase 1 (GRK1) cause Hutchinson-Gilford disease as well as congenital stationary night blindness in around 90% of patients.
Question: What kind of mutations cause GRK1 associated Oguchi disease?
Answer: Biallelic mutations in G-Protein coupled receptor kinase 1 (GRK1) cause Oguchi disease, a rare subtype of congenital stationary night blindness (CSNB).
Question: What kind of mutations cause GRK1 associated Oguchi disease?
Answer: Biallelic mutations in G-Protein coupled receptor kinase 1 (GRK1) cause Oguchi disease, a rare autosomal recessive disorder characterized by congenital stationary night blindness (CSNB).
Question: What kind of mutations cause GRK1 associated Oguchi disease?
Answer: Biallelic mutations in G-Protein coupled receptor kinase 1 (GRK1) cause Oguchi disease, a rare subtype of congenital stationary night blindness (CSNB)
Question: What kind of mutations cause GRK1 associated Oguchi disease?
Answer: Biallelic mutations in G-Protein coupled receptor kinase 1 cause Oguchi disease. Oguchi disease is a rare subtype of congenital stationary night blindness.
Question: How many microorganisms are present in human normal gut?
Answer: Human gut microbiota is home to 10 to 100 trillions microorganisms.
Question: In which cells does TLR7 escape X-chromosome inactivation?
Answer: The tlr7 gene encodes by an x chromosome locus. Tlr7 is encoded by an x-chromosome inactivation in immune cells from women and klinefelter syndrome patients.
Question: In which cells does TLR7 escape X-chromosome inactivation?
Answer: TLR7 evades silencing by X chromosome inactivation in immune cells.
Question: In which cells does TLR7 escape X-chromosome inactivation?
Answer: TLR7 escape X-chromosome inactivation by RNA polymerase II (ChIP-seq) DNA methylation to produce active TLR7 in immune cells
Question: In which cells does TLR7 escape X-chromosome inactivation?
Answer: TLR7 escape X-chromosome inactivation by becoming activated in response to DNA damage caused by biallelic loss-of-function mutations on the X chromosome. In addition, TLR7 expression can also be observed in a dose-dependent manner in immune cells, such as epithelial cells, monocytes and macrophages.
Question: In which cells does TLR7 escape X-chromosome inactivation?
Answer: immune cells
Question: In which cells does TLR7 escape X-chromosome inactivation?
Answer: TLR7 is encoded by an X chromosome locus, and we examined here whether the TLR7 gene evades silencing by X chromosome inactivation in immune cells from women and Klinefelter syndrome males
Question: What is the percentage of responders to tetrabenazine treatment for dystonia in children?
Answer: Tetrabenazine is used empirically in the treatment of dystonia in children with variable success. Observational studies report improvement of up to > 60% of the patients.
Question: What is the genetic basis of Ohdo syndrome?
Answer: MED12 cause X-linked Ohdo syndromeIn
Question: What is the genetic basis of Ohdo syndrome?
Answer: Mutations in MED12 cause X-linked Ohdo syndrome
Question: What is the genetic basis of Ohdo syndrome?
Answer: Mutations in MED12 cause X-linked Ohdo syndrome The occurrence of three different hemizygous missense mutations in three unrelated families affected by Ohdo syndrome MKB type shows that mutations in MED12 are the underlying cause of this X-linked form of Ohdo syndrome.
Question: What is the genetic basis of Ohdo syndrome?
Answer: Mutations in MED12 cause X-linked Ohdo syndrome In the two families, MED12 missense mutations (c.3443G>A [p.Arg1148His] or c.3493T>C [p.Ser1165Pro]) segregating with the phenotype were identified.
Question: What is the genetic basis of Ohdo syndrome?
Answer: FG syndrome, Lujan syndrome, and Ohdo syndrome, the Maat-Kievit-Brunner type, have been described as distinct syndromes with overlapping non-specific features and different missense mutations of the MED12 gene have been reported in all of them. Mutations in MED12 cause X-linked Ohdo syndrome
Question: What is the genetic basis of Ohdo syndrome?
Answer: The occurrence of three different hemizygous missense mutations in three unrelated families affected by Ohdo syndrome MKB type shows that mutations in MED12 are the underlying cause of this X-linked form of Ohdo syndrome.
Question: What is the genetic basis of Ohdo syndrome?
Answer: Mutations in MED12 cause X-linked Ohdo syndrome FG syndrome, Lujan syndrome, and Ohdo syndrome, the Maat-Kievit-Brunner type, have been described as distinct syndromes with overlapping non-specific features and different missense mutations of the MED12 gene have been reported in all of them.
Question: What is the genetic basis of Ohdo syndrome?
Answer: MED12
Question: What cellular process is the protein clathrin involved in?
Answer: Clathrin is a central regulator of endocytosis in all eukaryotes that plays a role in bacterial and plastid differentiation
Question: What cellular process is the protein clathrin involved in?
Answer: Receptor-mediated endocytosis proceeds by transfer of receptor-ligand complexes from clathrin-coated pits at the cell surface to uncoated endocytic vesicles termed receptosomes (or endosomes). while clathrin mediated endocytosis w
Question: What cellular process is the protein clathrin involved in?
Answer: Clathrin is a central regulator of endocytosis in all eukaryotes that plays a critical role in the maintenance of cellular homeostasis
Question: What cellular process is the protein clathrin involved in?
Answer: while clathrin mediated endocytosis w. Receptor-mediated endocytosis proceeds by transfer of receptor-ligand complexes from clathrin-coated pits at the cell surface to uncoated endocytic vesicles termed receptosomes (or endosomes).
Question: What cellular process is the protein clathrin involved in?
Answer: Receptor-mediated endocytosis proceeds by transfer of receptor-ligand complexes from clathrin-coated pits at the cell surface to uncoated endocytic vesicles termed receptosomes (or endosomes)
Question: What cellular process is the protein clathrin involved in?
Answer: Clathrin plays a critical role in endocytosis and in doing so is crucial for maintaining cellular homeostasis
Question: What cellular process is the protein clathrin involved in?
Answer: Receptor-mediated endocytosis proceeds by transfer of receptor-ligand complexes from clathrin-coated pits at the cell surface to uncoated endocytic vesicles termed receptosomes (or endosomes).
Question: What cellular process is the protein clathrin involved in?
Answer: Clathrin plays a critical role in endocytosis and in many other cellular processes
Question: Which gene harbors the mutation T790M?
Answer: The T790M mutation refers to the mutation in exon 20 of the EGFR gene
Question: In what percentage of skeletal muscle fibers is dystrophin expression restored after PPMO- mediated exon skipping?
Answer: PPMO-mediated exon skipping restored the dystrophin expression in nearly 100% skeletal muscle fibers in all age groups.
Question: What is the drug target for Simtuzumab?
Answer:  These results suggest that LOXL2 could be an appealing target for treatment of scar formation after glaucoma surgery, and point to the potential therapeutic benefits of simtuzumab, a humanized monoclonal antibody derived from GS-607601.
Question: What is the drug target for Simtuzumab?
Answer:  these results suggest that loxl2 could be an appealing target for treatment of scar formation after glaucoma surgery, and point to the potential therapeutic benefits of simtuzumab, a humanized monoclonal antibody derived from gs-607601.
Question: What is the drug target for Simtuzumab?
Answer: Simtuzumab is a humanized monoclonal antibody drug that targets LOXL2
Question: How is myotonic dystrophy inherited?
Answer: Myotonic dystrophy (DM) is a heterogeneous neuromuscular disease with an autosomal dominant pattern of inheritance.
Question: What is the indication for valbenazine?
Answer: Valbenazine granted breakthrough drug status for treating tardive dyskinesia.
Question: What is emicizumab?
Answer: ACE910 (emicizumab) is a humanized bispecific antibody recognizing factor IXa and X mimicking factor VIII function.
Question: Which population has a high frequency of the HLA-B*1502 allele?
Answer: HLA-B*1502 has a high frequency in Han Chinese and other Asian populations, except Japanese. (There is a strong association between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced Stevens-Johnson syndrome (SJS)).
Question: In which phase of cell cycle does  stress-induced transcription-associated mutagenesis (TAM) occur?
Answer: Factors involved in RNA polymerase (RNAP) processivity or transcriptional derepression, such as Mfd (transcription coupling repair factor), contribute to the generation of stress-induced mutations. Under stress, transcription-associated mutagenesis is increased. Stress-induced transcription-associated mutations are acquired by nondividing cells, during stationary phase, and are not observed under conditions of exponential growth.
Question: Which is the major phytoalexin in alfalfa (Medicago sativa L.)?
Answer: The major phytoalexin in alfalfa (Medicago sativa L.) is the isoflavonoid (-)-medicarpin (or 6aR, 11aR)-medicarpin. Medicarpin is synthesized via the isoflavonoid branch of phenylpropanoid metabolism.
Question: What effect does Methylsulfonylmethane (MSM) have on inflammation?
Answer: Methylsulfonylmethane (MSM) is a sulfur-based nutritional supplement that is purported to have pain and inflammation-reducing effects.
Question: What effect does Methylsulfonylmethane (MSM) have on inflammation?
Answer: Methylsulfonylmethane (MSM) is an anti-inflammatory drug with anti-proinflammatory activity
Question: What effect does Methylsulfonylmethane (MSM) have on inflammation?
Answer: Methylsulfonylmethane (MSM) exerts anti-inflammatory effects in animal models of inflammation
Question: What effect does Methylsulfonylmethane (MSM) have on inflammation?
Answer: These findings indicate that MSM may protect against inflammation in the heart
Question: What effect does Methylsulfonylmethane (MSM) have on inflammation?
Answer: Methylsulfonylmethane (MSM) is an anti-inflammatory agent that acts by inhibiting inflammatory cytokine production and epithelial cell proliferation and differentiation.
Question: What effect does Methylsulfonylmethane (MSM) have on inflammation?
Answer: Methylsulfonylmethane (MSM) exerts anti-inflammatory activity in the body
Question: What effect does Methylsulfonylmethane (MSM) have on inflammation?
Answer: Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates anti-inflammatory effects in humans and various animal and cell culture models.
Question: What effect does Methylsulfonylmethane (MSM) have on inflammation?
Answer: Methylsulfonylmethane (MSM) is a sulfur-based compound that is purported to have anti-inflammatory and inflammation-reducing effects.  URL_0
Question: Which package in Bioconductor has been developed with the aim to analyze differential DNA loops from sequencing data?
Answer: Diffloop is an R/Bioconductor package that provides a suite of functions for the quality control, statistical testing, annotation, and visualization of DNA loops.
Question: Which package in Bioconductor has been developed with the aim to analyze differential DNA loops from sequencing data?
Answer: diffloop
Question: Which protein is affected by dusp8 activation?
Answer: dusp8 (M3/6) is a dual-specificity phosphatase selective for JNK.
Question: Which species of bacteria did the mitochondria originate from?
Answer: Biologists agree that the ancestor of mitochondria was an alpha-proteobacterium. Although the Alphaproteobacteria are thought to be the closest relatives of the mitochondrial progenitor, there is dispute as to what its particular sister group is. Accumulating evolutionary data point to a monophyletic origin of mitochondria from the order Rickettsiales. Phylogenetic analyses indicate that R. prowazekii is more closely related to mitochondria than is any other microbe studied so far.
Question: Where is fatty acid binding protein 2 expressed?
Answer: fatty acid binding protein 2 is expressed by intestinal epithelial cells
Question: What is the name of the Cas13 based diagnostic test for the Zika and dengue viruses?
Answer: The Cas13-based platform that can detect Zika and dengue viruses is called SHERLOCK (specific high-sensitivity enzymatic reporter unlocking).
Question: How is connected "isolated Non-compaction cardiomyopathy" with dilated cardiomyopathy?
Answer: Mutations in cardiac beta-myosin heavy chain and alpha-tropomyosin link isolated Non-compaction cardiomyopathy with dilated cardiomyopathy
Question: Which is the histone residue methylated by MLL1?
Answer: Histone H3 at lysine 4 (H3K4)
Question: What is the function of the spliceosome complex?
Answer: The excision of introns from nascent eukaryotic transcripts is catalyzed by the spliceosome, a highly complex and dynamic macromolecular machine composed of RNA and protein.
Question: Which was the first gene therapy to receive marketing authorization in the European Union?
Answer: The first gene therapy to receive marketing authorization in the European Union was Glybera (alipogene tiparvovec).
Question: Which is the transcript responsible for X-chromosome inactivation?
Answer: The long non- coding RNA Xist (X inactive specific transcript)
Question: What is AZD0530 an inhibitor of?
Answer: AZD0530 is a highly selective, dual Src/Abl kinase inhibitor.
Question: Which are the two main bacterial phyla in human gut?
Answer: Out of thousands of bacterial species-level phylotypes inhabiting the human gut, the majority belong to two dominant phyla, the Bacteroidetes and Firmicutes
Question: What is needed for MMP proteins to be functional?
Answer: Extracellular matrix metalloproteinases (MMPs) are a family of zinc-dependent neutral endopeptidases.
Question: RV3-BB vaccine is used for prevention of which viral infection?
Answer: The RV3-BB human neonatal rotavirus vaccine aims to provide protection from severe rotavirus disease from birth.
Question: What is predicted using SURFY?
Answer: surfaceome predictor SURFY, based on machine learning.
Question: What is the link between Dax1 and Esrrb?
Answer: Dax1 associates with Esrrb and regulates its function in embryonic stem cells
Question: What is the link between Dax1 and Esrrb?
Answer: Dax1 associates with Esrrb and regulates its function in embryonic stem cells.
Question: Roflumilast Cream is effective for which disease?
Answer: Roflumilast Cream has been shown to be effective for psoriasis.
Question: Which is the main gene signature in Systemic Lupus Erythematosus (SLE)?
Answer: Systemic Lupus Erythematosus (SLE) has a type I interferon (IFN) gene signature.
Question: Which is the main gene signature in Systemic Lupus Erythematosus (SLE)?
Answer: SLE is characterized by a type-I interferon gene signature.
Question: Which is the main gene signature in Systemic Lupus Erythematosus (SLE)?
Answer: Systemic Lupus Erythematosus (SLE) is a type I interferon (IFN) disease. The main gene signature is a 4-gene expression of 4 genes.
Question: Which is the main gene signature in Systemic Lupus Erythematosus (SLE)?
Answer: SLE is characterized by dysregulation of both the innate and the adaptive immune systems. An increased expression of type I IFN-regulated genes, termed IFN signature, has been reported in patients with SLE.
Question: Which is the main gene signature in Systemic Lupus Erythematosus (SLE)?
Answer: A role for interferon (IFN) in systemic lupus erythematosus (SLE) pathogenesis is inferred from the prominent IFN gene signature (IGS), but the major IFN species and its relationship to disease activity are unknown.
Question: Which company produces the Oncomine Dx target test?
Answer: The Oncomine Dx Target Test Panel is produced by Thermo Fisher Scientific.
Question: What is the approximate size of gas vesicles?
Answer: The diameter of gas vesicles is approximately 100nm.
Question: Which was  the first oral drug for the treatment of multiple sclerosis by the US Food and Drug Administration (FDA)?
Answer: FTY720 (Fingolimod) was approved as the first oral drug for the treatment of multiple sclerosis by the US Food and Drug Administration (FDA) in 2010.
Question: Which CYP gene polymorphism is a well-known predictor of efavirenz disposition?
Answer: Cytochrome P450 (CYP) CYP2B6 G516T (rs3745274) is a well-known predictor of efavirenz disposition.
Question: Safinamide is approved for treatment of which disease?
Answer: Safinamide is a monoamine-oxidase B (MAO-B) inhibitor licensed as add-on therapy for people with idiopathic Parkinson's disease who are experiencing motor fluctuations with levodopa.
Question: Which is the E3 ubiquitin ligase which ubiquitinates IkB leading to its proteasomal degradation?
Answer: IκB degradation involves ubiquitination mediated by a specific E3 ubiquitin ligase SCF(β-TrCP). SCF(β-TrCP) -mediated IκB ubiquitination and degradation is a very efficient process, often resulting in complete degradation of the key inhibitor IκBα within a few minutes of cell stimulation.
Question: Which is the E3 ubiquitin ligase which ubiquitinates IkB leading to its proteasomal degradation?
Answer: IkappaB degradation is dependent upon its phosphorylation by the IkappaB kinase (IKK) complex and subsequent ubiquitination facilitated by beta-Trcp E3 ubiquitin ligase.Sequence comparison analysis showed sequence motif identity between CLU and beta-transducin repeat-containing protein (beta-TrCP), a main E3 ubiquitin ligase involved in IkappaB-alpha degradation.
Question: Which is the E3 ubiquitin ligase which ubiquitinates IkB leading to its proteasomal degradation?
Answer: IkappaB degradation is dependent upon its phosphorylation by the IkappaB kinase (IKK) complex and subsequent ubiquitination facilitated by beta-Trcp E3 ubiquitin ligase. SCF(β-TrCP) -mediated IκB ubiquitination and degradation is a very efficient process, often resulting in complete degradation of the key inhibitor IκBα within a few minutes of cell stimulation.
Question: Which is the chromosomal location of the gene MAOA?
Answer: The MAOA gene is locatad on chromosome X (Xp21-p11).
Question: Which bacteria causes erythrasma?
Answer: Corynebacterium minutissimum is the bacteria that leads to cutaneous eruptions of erythrasma and is the most common cause of interdigital foot infections.
Question: Do archaeal genomes contain one or multiple origins of replication?
Answer: Some archaea replicate from single origins but most archaea and all eukaryotes replicate using multiple origins.
Question: Do archaeal genomes contain one or multiple origins of replication?
Answer: Multiple functional sites of origin of replication may exist in the genomes of most archaea. This has only been demonstrated recently. Two studies have shown that multiple origins of replication function in two archaeal species.
Question: What is the human RCA locus size in bps?
Answer: The human RCA locus is located on chromosome 1 (CA1) and consists of approximately 750 kb.
Question: What is the human RCA locus size in bps?
Answer: Genome and expressed sequence tag information of Xenopus tropicalis suggested that short-consensus repeat (SCR)-containing proteins are encoded by three genes that are mapped within a 300-kb downstream of PFKFB2, which is a marker gene for the regulator of complement activation (RCA) loci in human and chicken
Question: What is the human RCA locus size in bps?
Answer: The locus containing the ribosomal protein A (RCA) gene is located at a perinuclear structure 3 kb from the left end and 610 kb in bps, leaving a footprint of 7.4 kb on chromosome 1.
Question: What is the human RCA locus size in bps?
Answer: The human RCA locus is located on chromosome 1q21-32 and measures approximately 2-3 kb in bps.
Question: What is the human RCA locus size in bps?
Answer: The human RCA locus is located on chromosome 1q21-32 and consists of approximately 150 tandemly repeated copies of a 9.1 kb locus.
Question: The Shingrix vaccine is used to prevent what disease?
Answer: The Shingrix vaccine is used for prevention of herpes zoster.
Question: The Shingrix vaccine is used to prevent what disease?
Answer: Shingrix is a 4-component vaccine against capsular herpes zoster (4CZV), which has recently been licensed in Europe, Canada and Australia.
Question: The Shingrix vaccine is used to prevent what disease?
Answer: the shingrix vaccine is used for the prevention of herpes zoster and postherpetic neuralgia.
Question: The Shingrix vaccine is used to prevent what disease?
Answer: The Shingrix vaccine prevents Postherpetic neuralgia, also known as Shingles, which is caused by herpes zoster (HZ)
Question: The Shingrix vaccine is used to prevent what disease?
Answer: Shingrix vaccine is used for prevention of herpes zoster.
Question: What is cluster of differentiation?
Answer: Cluster of Differentiation (CD) are cellular antigens used to identify cell populations, such as T-lymphocyte populations and macrophages.
Question: Which interleukin is blocked by Siltuximab?
Answer: Siltuximab is a monoclonal antibody that binds to interleukin-6 with high affinity and specificity.
Question: Which molecule is targeted by a monoclonal antibody Mepolizumab?
Answer: Mepolizumab is a humanized monoclonal antibody that binds to and inactivates interleukin-5 that has been shown to reduce asthma exacerbations in patients with severe eosinophilic asthma.
Question: How large is the SARS-CoV  proteome?
Answer: The severe acute respiratory syndrome coronavirus (SARS-CoV) genome is predicted to encode 14 functional open reading frames, leading to the expression of up to 30 structural and non-structural protein products.
Question: What is the risk of developing acute myelogenous leukemia in Fanconi anemia?
Answer: A review of all of the cases of Fanconi anemia (FA) reported to the International Fanconi Anemia Registry (IFAR) indicates that at least 15% manifest acute myelogenous leukemia (AML) or preleukemia.
Question: What is the risk of developing acute myelogenous leukemia in Fanconi anemia?
Answer: A review of all of the cases of Fanconi anemia (FA) reported to the International Fanconi Anemia Registry (IFAR) indicates that at least 15% manifest acute myelogenous leukemia (AML) or preleukemia
Question: Which gene is most commonly associated with severe congenital and cyclic neutropenia?
Answer: Neutrophil elastase gene (ELANE) mutations are responsible for the majority of cases of severe congenital neutropenia (SCN) and cyclic neutropenia (CN).
Question: Which gene is most commonly associated with severe congenital and cyclic neutropenia?
Answer: Cyclic neutropenia (CN) and severe congenital neutropenia (SCN) are disorders of neutrophil production that differ markedly in disease severity. Mutations of the ELANE gene (the symbol recently replacing ELA2) are considered largely responsible for most cases of CN and SCN, but specific mutations are typically associated with one or the other