anand-s/m_qalm huggingface dataset:
Question: What bacteria is associated with Gastric cancer and peptic ulcers?
Answer: Helicobacter pylori (H. pylori), a gram-negative microaerophilic bacterial pathogen that colonizes the stomachs of more than half of all humans, is linked to chronic gastritis, peptic ulcers and gastric cancer.
Question: What bacteria is associated with Gastric cancer and peptic ulcers?
Answer: Peptic ulcer and gastric cancer are caused by the same bacteria, Helicobacter pylori.
Question: Approximately how many recombination hotspots have been found in the yeast genome?
Answer: In the fission yeast genome DSBs are located within 194 prominent peaks separated on average by 65-kbp intervals of DNA that are largely free of DSBs.
Question: In which chromosome are transgenes inserted in the case of the LiPS-A3S line?
Answer: Transgenesis of human pluripotent stem cells (hPSCs) can enable and empower a variety of studies in stem cell research, including lineage tracing and functional genetics studies. While in recent years much progress has been made in the development of tools for gene targeting, little attention has been given to the identification of sites in the human genome where transgenes can be inserted and reliably expressed. One cell line/clone, LiPS-A3, has an integration site in chromosome 15 maintaining robust expression without silencing. Different transgenes can be inserted therein rapidly and efficiently through recombinase-mediated cassette exchange (RMCE). The LiPS-A3 line can greatly facilitate the insertion of reporter and other genes in hPSCs. Targeting transgenes in the LiPS-A3S genomic locus can find broad applications in stem cell research and possibly cell and gene therapy.
Question: In which chromosome are transgenes inserted in the case of the LiPS-A3S line?
Answer: The LiPS-A3S line of human pluripotent stem cells is inserted via transgenesis from chromosome 15.
Question: In which chromosome are transgenes inserted in the case of the LiPS-A3S line?
Answer: The LiPS-A3S line of human pluripotent stem cells is inserted into chromosome 15.
Question: In which chromosome are transgenes inserted in the case of the LiPS-A3S line?
Answer: Human pluripotent stem cells (hPSCs) can enable and empower a variety of studies in stem cell research, including lineage tracing and functional genetics studies. In recent years much progress has been made in the development of tools for gene targeting, little attention has been given to the identification of sites in the human genome where transgenes can be inserted and reliably expressed. The LiPS-A3S line of chromosome 15 is one of the few genes with an integration site in chromosome 15.
Question: Name monoclonal antibody against SLAMF7.
Answer: Elotuzumab is a humanized monoclonal antibody specific for signaling lymphocytic activation molecule-F7 (SLAMF7, also known as CS1, CD319, or CRACC) that enhances natural killer cell-mediated antibody-dependent cellular cytotoxicity of SLAMF7-expressing myeloma cells.
Question: Through which molecular pathway does LB-100 reduce hepatic steatosis?
Answer: PP2A inhibition by LB100 significantly ameliorates hepatic steatosis by regulating hepatic lipogenesis and fatty acid oxidation via the AMPK/Sirt1 pathway.
Question: What is the association of the protein RAB10 and Alzheimers disease?
Answer: The genes SEC22B, RAB10 and FLT1 may be potential biomarkers of AD.
Question: Which ultraconserved element is associated with Embryonic Stem Cells (ESC) self-renewal?
Answer: Ultraconserved elements (UCEs) show the peculiar feature to retain extended perfect sequence identity among human, mouse, and rat genomes. Most of them are transcribed and represent a new family of long non-coding RNAs (lncRNAs), the transcribed UCEs (T-UCEs). Despite their involvement in human cancer, the physiological role of T-UCEs is still unknown. A lncRNA containing the uc.170+, named T-UCstem1, was identified with in vitro and in vivo evidence that it plays essential roles in embryonic stem cells (ESCs) by modulating cytoplasmic miRNA levels and preserving transcriptional dynamics.
Question: Which tumor suppressor is referred to as "the guardian of the genome"?
Answer: The major tumour suppressor protein, p53, is one of the most well-studied proteins in cell biology. It plays a crucial role in regulating the transcription of numerous genes responsible for cells cycle arrest, DNA repair, angiogenesis, cell senescence, or apoptosis in response to various stress signals, and is considered one of the most important players in the development of cancer. p53 contributes to the maintenance of genomic stability. Thus, p53 has been described as "the guardian of the genome".
Question: Which disease of the central nervous system is characterized by the presence of Lewy bodies?
Answer: Parkinson s disease (PD) is one of the most common degenerative disorders of the central nervous system that produces motor and non-motor symptoms. The majority of cases are idiopathic and characterized by the presence of Lewy bodies containing fibrillar α-synuclein
Question: Which disease of the central nervous system is characterized by the presence of Lewy bodies?
Answer: Parkinson's disease (PD) is one of the most common degenerative disorders of the central nervous system that produces motor and non-motor symptoms. The majority of cases are idiopathic and characterized by the presence of Lewy bodies containing fibrillar α-synuclein.
Question: Which disease of the central nervous system is characterized by the presence of Lewy bodies?
Answer: Parkinsons disease (PD) is one of the most common degenerative disorders of the central nervous system that produces motor and non-motor symptoms. The protein α-synuclein is well recognized to contribute to the pathogenesis of Parkinson disease and is the major component of Lewy bodies and Lewy neurites
Question: Which tool exist for predicting drug synergy with deep learning?
Answer: Deep Learning has had an impact in many research areas by achieving new state-of-the-art model performance. DeepSynergy has been developed as a tool that uses chemical and genomic information as input information, a normalization strategy to account for input data heterogeneity, and conical layers to model drug synergies.
Question: Which tool exist for predicting drug synergy with deep learning?
Answer: DeepSynergy is an online tool for predicting drug synergy with deep learning. It is a method for predicting anti-cancer drug synergy based on a semi-supervised learning algorithm that is trained on a corpus of k-nearest neighbor data and combines pharmacological, structural and pharmacological features extracted from a large variety of biological datasets.
Question: Which is the primary interacting protein of BLK?
Answer: The B cell adaptor protein with ankyrin repeats (BANK1) and the B lymphoid tyrosine kinase (BLK) have been genetically associated with autoimmunity. The proteins of these genes interact physically and work in concert during B-cell signaling.
Question: Which is the primary interacting protein of BLK?
Answer: Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK.
Question: Which is the primary interacting protein of BLK?
Answer: BLK interacts with at least two of the three kinases in the B-cell/proteasome pathway, namely the transcription factor BANK1 and the chromatin-associated transcription factor 1 (CACGT1).
Question: Which is the primary interacting protein of BLK?
Answer: Primary interacting protein of BLK (also known as BANK1)
Question: Which is the primary interacting protein of BLK?
Answer: Primary interacting protein of BLK is Cdk1-binding protein 1 (Bik1/Nbk1).
Question: Which is the primary interacting protein of BLK?
Answer: The genes BANK1 and BLK were recently described as associated with SLE a genetic interaction between BANK1 and BLK, and demonstrates that these molecules interact physically.
Question: Which is the primary interacting protein of BLK?
Answer: BLK activity is regulated by two interacting proteins, BANK1 and BANK2.
Question: Which is the primary interacting protein of BLK?
Answer: a genetic interaction between BANK1 and BLK, and demonstrates that these molecules interact physically.
Question: Which is the primary interacting protein of BLK?
Answer: Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. a genetic interaction between BANK1 and BLK, and demonstrates that these molecules interact physically.
Question: Which is the primary interacting protein of BLK?
Answer: A The genes BANK1 and BLK were recently described as associated with SLE
Question: Which is the primary interacting protein of BLK?
Answer: Autophagy-related gene 5 (ATG5), ATG7, B-lymphoid tyrosine kinase (BLK) and B-cell scaffold protein with ankyrin repeats 1 (BANK1) are involved in B-cell signaling;
Question: Which is the primary interacting protein of BLK?
Answer: bank1
Question: Which mutation is associated with PLMS (periodic limb movements in sleep)?
Answer: missense substitution, Met1Val (M1V), was identified in the DCX gene
Question: Which is the catalytic activity of the protein encoded by the gene KMT2C? 
Answer: The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene enhancers.
Question: Which is the E3 ubiquitin ligase of Hsp90?
Answer: Carboxyl terminus of hsc70-interacting protein (CHIP) can mediate ubiquitination of the 90 kDa heat-shock protein (hsp90) in vitro, with subsequent proteasomal degradation of the chaperone.
Question: Which protein is regulated by Tudor interacting repair regulator (TIRR)?
Answer: Tudor interacting repair regulator (TIRR) regulates P53-binding protein 1 (53BP1) by masking its histone methyl-lysine binding function.
Question: Where is the TAZ (G4.5) is located in humans?
Answer: TAZ gene (G4.5) is located on Xq28 in humans.
Question: What is the typical rash associated with gluten ?
Answer: Dermatitis herpetiformis is a lifelong, gluten-sensitive, blistering skin disease with pathognomonic immunoglobulin (Ig)A deposits in the papillary dermis.
Question: Fecal transplantation is used to treat infection with what bacteria?
Answer: Fecal microbiota transplantation is used to treat Clostridium difficile infection
Question: Which gene is implicated in the metabolism of codeine, and its polymorphisms in the mother can pose a risk to breastfeeding children?
Answer: Mothers with a CYP2D6 ultrarapid metabolizer phenotype may expose their infants to risk of adverse events when taking codeine while breastfeeding, by producing more of the active metabolite, morphine.
Question: Which algorithm has been developed for detecting expansions of tandem repeats?
Answer: Identifying large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-genome sequencing (WGS) data. A solution to this problem is an important step toward integrating WGS into precision medicine. For that purpose, ExpansionHunter has been developed as a software tool that, using PCR-free WGS short- read data, can genotype repeats at the locus of interest, even if the expanded repeat is larger than the read length.
Question: Which algorithm has been developed for detecting expansions of tandem repeats?
Answer: Identifying large expansions of short tandem repeats (STRs), such as those that cause amyotrophic lateral sclerosis (ALS) and fragile X syndrome, is challenging for short-read whole-genome sequencing (WGS) data. A solution to this problem is an important step toward integrating WGS into precision medicine. ExpansionHunter has been developed as a tool which using PCR-free WGS short-read data, can genotype repeats at the locus of interest, even if the expanded repeat is larger than the read length. ExpansionHunter can be used to accurately detect known pathogenic repeat expansions and provides researchers with a tool that can be used to identify new pathogenic repeat expansions.
Question: Which is the conserved motif of DEAD box proteins?
Answer: The conserved motif is: Asp(D)-Glu-(E)-Ala(A)-Asp(D)
Question: What is the function of the protein Cuf1?
Answer: Cuf1 is a copper-sensing transcription factor.
Question: With which cancers has the loss of SMARCB1 been associated?
Answer: Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1 Loss of SMARCB1/INI1 expression is considered to be a hallmark for childhood chordomas (CCs)
Question: With which cancers has the loss of SMARCB1 been associated?
Answer: We therefore sought to identify novel mutations to better understand chordoma biology and to potentially identify therapeutic targets Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1
Question: With which cancers has the loss of SMARCB1 been associated?
Answer: The diagnosis is all the more challenging that other poorly differentiated cancers lose SMARCB1 expression, such as epithelioid sarcomas (ES), renal medullary carcinomas (RMC) or undifferentiated chordomas (UC) Loss of SMARCB1/INI1 expression is considered to be a hallmark for childhood chordomas (CCs)
Question: With which cancers has the loss of SMARCB1 been associated?
Answer: Loss of SMARCB1/INI1 expression is considered to be a hallmark for childhood chordomas (CCs).
Question: With which cancers has the loss of SMARCB1 been associated?
Answer: Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1. Loss of SMARCB1/INI1 expression is considered to be a hallmark for childhood chordomas . The diagnosis is all the more challenging that other poorly differentiated cancers lose SMARCB1 expression, such as epithelioid sarcomas .
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment.
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells. Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence.
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells.
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence.
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment. Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells.
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Instead, cLADs are universally characterized by long stretches of DNA of high A/T content.
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: In metazoans, the nuclear lamina is thought to play an important role in the spatial organization of interphase chromosomes, by providing anchoring sites for large genomic segments named lamina-associated domains (LADs). Some of these LADs are cell-type specific, while many others appear constitutively associated with the lamina. Constitutive LADs (cLADs) may contribute to a basal chromosome architecture. cLADs are universally characterized by long stretches of DNA of high A/T content. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level.
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment. Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level
Question: What is the nucleotide composition of the Lamin Associated Domains (LADs)?
Answer: Analysis of paralogs suggests that during evolution changes in A/T content have driven the relocation of genes to and from the nuclear lamina, in tight association with changes in expression level. Instead, cLADs are universally characterized by long stretches of DNA of high A/T content. Constitutive nuclear lamina-genome interactions are highly conserved and associated with A/T-rich sequence. This suggests that the A/T rule represents a default positioning mechanism that is locally overruled during lineage commitment. Cell-type specific LADs also tend to adhere to this "A/T rule" in embryonic stem cells, but not in differentiated cells.
Question: What nerve is involved in carpal tunnel syndrome?
Answer: Carpal tunnel syndrome (CTS) is a focal compressive neuropathy of the median nerve at the level of the wrist.
Question: What nerve is involved in carpal tunnel syndrome?
Answer: Carpal tunnel syndrome (CTS) is a medical condition due to compression of the median nerve as it travels through the wrist at the carpal tunnel.
Question: What does MetaHIT stand for?
Answer: Metagenomics of the Human Intestinal Tract (MetaHIT) project are focusing mainly on the human microbiome
Question: What is the effect of the absence of Saccharomyces cerevisiae Rrm3p?
Answer: The Saccharomyces cerevisiae RRM3 gene encodes a 5' to 3' DNA helicase. While replication of most of the yeast genome was not dependent upon Rrm3p, in its absence, replication forks paused and often broke at an estimated 1400 discrete sites, including tRNA genes, centromeres, inactive replication origins, and transcriptional silencers. These replication defects were associated with activation of the intra-S phase checkpoint. Activation of the checkpoint was critical for viability of rrm3Delta cells, especially at low temperatures.
Question: What is the effect of the absence of Saccharomyces cerevisiae Rrm3p?
Answer: The Saccharomyces cerevisiae RRM3 gene encodes a 5  to 3  DNA helicase. While replication of most of the yeast genome was not dependent upon Rrm3p, in its absence, replication forks paused and often broke at an estimated 1400 discrete sites, including tRNA genes, centromeres, inactive replication origins, and transcriptional silencers. These replication defects were associated with activation of the intra-S phase checkpoint. Activation of the checkpoint was critical for viability of rrm3Delta cells, especially at low temperatures
Question: To which family does the Zika virus belong?
Answer: The Zika virus belongs to the family Flaviviridae.
Question: Do origins of replication close to yeast centromeres fire early or late?
Answer: Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase we discovered that each centromere is associated with a replication origin that is the first to fire on its respective chromosome.
Question: Do origins of replication close to yeast centromeres fire early or late?
Answer: In yeast each centromere is associated with a replication origin that is the first to fire on its respective chromosome.
Question: Do origins of replication close to yeast centromeres fire early or late?
Answer: Epigenetically-inherited centromere and neocentromere DNA replicates earliest in S-phase we discovered that each centromere is associated with a replication origin that is the first to fire on its respective chromosome. a neocentromere became the first to replicate and became associated with origin recognition complex (ORC) components.
Question: On what chromosome is the gene for "SILVER" coat color found for the domestic cat?
Answer: Linkage mapping defined a genomic region for SILVER as a 3.3-Mb region, (95.87-99.21 Mb) on chromosome D2 in the domestic cat.
Question: On what chromosome is the gene for "SILVER" coat color found for the domestic cat?
Answer: the gene for "silver" coat color found for the domestic cat is located on chromosome d2.
Question: What is the Her2 status in Li-Fraumeni syndrome?
Answer: In the background of a germline TP53 mutation of the Li-Fraumeni syndrome, the Her2 status was found to be positive in 63-83% of the cases.
Question: Which gene is responsible for the Liebenberg syndrome?
Answer: Liebenberg syndrome is a genetic disease caused by heterozygous mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene. Patients present with prominent neurological, medical, and behavioral symptoms.
Question: Which gene is responsible for the Liebenberg syndrome?
Answer: We discuss the genetic abnormality that causes Liebenberg syndrome, the genomic rearrangement at the PITX1 locus on chromosome 5
Question: Which gene is responsible for the Liebenberg syndrome?
Answer: We re-define the phenotype of Liebenberg syndrome as a transformation of the upper limbs to reflect lower limb characteristics. We speculate that the area of deletion contains a regulatory sequence that suppresses the expression of PITX1 in the upper limb buds.
Question: Which gene is responsible for the Liebenberg syndrome?
Answer: Liebenberg syndrome is caused by genetic changes near the PITX1 gene. The protein produced from this gene plays a critical role in lower limb development by controlling the activity of other genes involved in limb development, directing the shape and structure of bones and other tissues in the legs and feet.