anand-s/m_qalm huggingface dataset:
Question: What classes of drugs does Retapamulin belong to?
Answer: Retapamulin is a member of the pleuromutilin family of antibiotics.
Pleuromutilins have a potential to be developed as a new class of antibiotics for  use in humans. This class includes valnemulin, tiamulin, and retapamulin.
Retapamulin belongs to the class of gentamycin-resistant antibiotics.
Question: What is a miR?
Answer: The discovery of microRNAs (miRNAs) has opened an entire new avenue for drug development. These short (15-22 nucleotides) noncoding RNAs, which function in RNA silencing and posttranscriptional regulation of gene expression, have been shown to critically affect numerous pathways in both development and disease progression.
Question: What is the mode of inheritance of short QT syndrome?
Answer: The short QT syndrome has an autosomal dominant mode of inheritance.
Question: What is the effect induced by sympathetic nervous system on pupil size?
Answer: Pupil size is determined by the interaction of the parasympathetic and the sympathetic nervous system. The sympathetic nervous system acts either directly on the dilator muscle (peripherally) or centrally by inhibiting the Edinger-Westphal nucleus. Thus, the sympathetic nervous system mediates pupillary dilatation.
Question: Which is the main epigenetic difference between poised and constitutive enhancers?
Answer: We find that histone H3K27ac distinguishes active enhancers from inactive/poised enhancer elements containing H3K4me1 alone.
Histone H3K27ac separates active from poised enhancers and predicts developmental state.
. The poised enhancer signature, involving H3K4me1 and low levels of H3K27ac, has been reported to mark inactive enhancers that are poised for future activation.. Histone H3K27ac separates active from poised enhancers and predicts developmental state.. We find that histone H3K27ac distinguishes active enhancers from inactive/poised enhancer elements containing H3K4me1 alone.. These chromatin domains, mostly constitutive, may have been used as genomic niches where novel regulations could evolve due to both the preexistence of a structural backbone poised to integrate novel regulatory inputs, and a highly adaptive transcriptional readout. These results support a model in which the PRC2 complex is redistributed to poised enhancers in H3.3K27M mutant cells and contributes to tumorigenesis in part by locally enhancing H3K27me3, and hence silencing of tumor suppressor genes
Histone H3K27ac distinguishes active enhancers from inactive/poised enhancer elements containing H3K4me1 alone.
Question: How many cysteines have alpha-defensins?
Answer: Alpha defensins contain six cysteines, which form three well defined disulfide bridges under oxidizing conditions.
Question: When was Fluzone Intradermal replaced with Fluzone Intradermal Quadrivalent?
Answer: Fluzone Intradermal was replaced with Fluzone Intradermal Quadrivalent vaccine in advance of the 2015-2016 season.
Question: Which is the main calcium binding protein of the sarcoplasmic reticulum?
Answer: Calsequestrin is the major calcium-binding protein of cardiac and skeletal muscles whose function is to sequester Ca(2+ )in the lumen of the sarcoplasmic reticulum (SR).
Calsequestrin is the major calcium-binding protein of cardiac and skeletal muscles whose function is to sequester Ca(2+ )in the lumen of the sarcoplasmic reticulum (SR).
Question: Name a CFL2 mutation which is associated with nemaline myopathy?
Answer: A mutation in CFL2 was identified in a family with nemaline myopathy, namely a homozygous missense mutation in exon 2 (c.19G>A, p.Val7Met).
Question: What is the purpose of the 123 dihydrorhodamine assay?
Answer: detection of inheritance pattern in thirty-three mexican males with chronic granulomatous disease
Dihydrorhodamine assays measure oxidative bursts and are used to quantify cell activation via respiratory bursts. Nitroblue-tetrazolium dye reduction test and 123 dihydro-rhodamine assay by flow cytometry are the screening tests for Chronic Granulomatous Disease.
Dihydrorhodamine assay (DRB) is a simple, reliable, and valid method for studying oxidative stress, in particular oxidative stress and reactive oxygen species.
We detected the female relatives within the families of male patients with CGD, and carried out the 123 dihydrorhodamine (DHR) assay in all female participants. Detection of inheritance pattern in thirty-three Mexican males with chronic granulomatous disease through 123 dihydrorhodamine assay.
Question: Sweat Chloride Testing is used  for which disease?
Answer: Sweat Chloride Testing is used to diagnose cystic fibrosis. CFTR dysfunction can be demonstrated using sweat chloride testing.
Question: Which Python tool has been developed for network-based stratification of tumor mutations?
Answer: PyNBS is a modularized Python 2.7 implementation of the network-based stratification (NBS) algorithm for stratifying tumor somatic mutation profiles into molecularly and clinically relevant subtypes.
Question: Which type of analysis does DeSeq2 perform?
Answer: DeSeq2 is a software for differential gene expression analysis of RNA sequencing data.
Both TMM and DESeq2 are widely used for differential gene expression analysis.
DeSeq2 performed differential gene expression analysis of paired-end tag sequencing data.
DeSeq2 supports differential gene expression analysis by combining multiple sources of evidence.
DeSeq2 enables differential gene expression analysis of multiple cellular origins.
DesSeq2 is widely used for differential gene expression analysis.
DESeq2 is a method for differential analysis of count data. It is used for the calculation of fold change and dispersion of RNA-seq data.
Question: What is the lay name of the treatment for CCSVI (chronic cerebro-spinal venous insufficiency)  in multiple sclerosis.
Answer: The so-called "LIberation therapy" is in fact Endovascular Treatment and consists of PTA (Percutaneous Transluminal Angioplasty), which is dilatation of the internal jugular and/or azygous veins by a catheter venography. Stent placement is optional but has been strongly advised against as being dangerous.
Question: How many genes are in the gene signature screened by MammaPrint?
Answer: Mammaprint has a 70 gene signature.
Question: Which peptide plays a pivotal role in human cystatin C fibrillization?
Answer: Human cystatin C (HCC) is a low molecular weight member of the cystatin family (type2). HCC consists of 120 amino acids. Normally it is an inhibitor of cysteine proteases, but in pathological conditions it forms amyloid fibrils in brain arteries of young adults. An 'aggregation-prone' pentapeptide ((47)LQVVR(51)) was located within the HCC sequence using AmylPred, an 'aggregation-prone' peptide prediction algorithm developed in our lab. This peptide was synthesized and self-assembled into amyloid-like fibrils in vitro, as electron microscopy, X-ray fiber diffraction, Attenuated Total Reflectance Fourier-Transform Spectroscopy and Congo red staining studies reveal. Thus, the (47)LQVVR(51) peptide seems to have an important role in HCC fibrillization.
Human cystatin C (HCC) is a low molecular weight member of the cystatin family (type2). HCC consists of 120 amino acids. Normally it is an inhibitor of cysteine proteases, but in pathological conditions it forms amyloid fibrils in brain arteries of young adults. An 'aggregation-prone' pentapeptide ((47)LQVVR(51)) was located within the HCC sequence using AmylPred, an 'aggregation-prone' peptide prediction algorithm. This peptide was synthesized and self-assembled into amyloid-like fibrils in vitro, as electron microscopy, X-ray fiber diffraction, Attenuated Total Reflectance Fourier-Transform Spectroscopy and Congo red staining studies reveal. Thus, the (47)LQVVR(51) peptide seems to have an important role in HCC fibrillization.
Question: What is the generic name of Gliolan?
Answer: 5-aminolevulinic acid (or 5-ALA) is the generic name of Gliolan. It is approved for fluorescence-guided resections of adult malignant gliomas.
Question: Which workflow in Bioconductor has been developed for accessing human RNA-seq samples?
Answer: The recount2 resource is composed of over 70,000 uniformly processed human RNA-seq samples spanning TCGA and SRA, including GTEx.
Question: What is drug target for olaparib?
Answer: Olaparib(Lynparza) is a PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
Olaparib is a Poly(ADP-ribose) Polymerase (PARP) Inhibitor
Question: Which intoxication is associated with Burton's line?
Answer: Burton's line is characteristic for lead poisoning.
Question: Rachmilewitz Index is used for which diseases?
Answer: Rachmilewitz Index is used for assessment of endoscopic disease activity of patients with ulcerative colitis.
Question: Losigamone can be used for treatment of which disease?
Answer: Losigamone is sometimes used as an add-on therapy for epilepsy.
Question: How is the STING protein activated?
Answer: During DNA virus infections, detection of cytosolic DNA by the cGAS-STING pathway leads to activation of IFN-β.
Question: What is an exosome?
Answer: Exosomes are a subset of extracellular vesicles (EVs) that have important roles in intercellular communication. They contain and carry bioactive molecules within their membranes which are delivered to target cells.
Question: What molecule is targeted by Avelumab?
Answer: Avelumab is a monoclonal antibody that binds programmed death-ligand 1 (PD-L1).
Question: What disease in Loxapine prominently used for?
Answer: The best indication of loxapine is paranoid schizophrenia.
Question: What is trichotillomania?
Answer: Trichotillomania is a hair pulling disorder.
Question: What is the indication of Daonil (Glibenclamide)?
Answer: Glibenclamide is an antidiabetic and antiglycemic, used in severe NIDDM, and increasingly viewed as a rational alternative to insulin therapy.
Question: What is the role of 3,4-diaminobenzoic acid derivatives in the immune system?
Answer: 3,4-diaminobenzoic acid derivatives are inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties. Cell-based analysis indicated that the lead compounds can be effective in downregulating macrophage activation induced by lipopolysaccharide and interferon-γ as well as cross-presentation by bone marrow-derived dendritic cells.
Question: Which tissue secretes vaspin?
Answer: Visceral adipose tissue-derived serine protease inhibitor (Vaspin) is an adipocytokine that has been shown to exert anti-inflammatory effects and inhibits apoptosis under diabetic conditions.
Question: What was the purpose of the FANTOM3 project?
Answer:  The FANTOM3 annotation system, consisting of automated computational prediction, manual curation, and final expert curation, facilitated the comprehensive characterization of the mouse transcriptome, and could be applied to the transcriptomes of other species
Functional Annotation Of Mouse 3 (FANTOM3), an international collaboration research project focusing on expanding the transcriptome and subsequent analyses. The FANTOM3 annotation system, consisting of automated computational prediction, manual curation, and final expert curation, facilitated the comprehensive characterization of the mouse transcriptome, and could be applied to the transcriptomes of other species.
Question: Which domain of the MOZ/MYST3 protein complex associates with histone H3?
Answer: The double PHD finger domain of MOZ/MYST3 induces a-helical structure of the histone H3 tail
The double PHD finger domain of MOZ/MYST3 induces a-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification In addition to sampling H3 and H4 modification status, we show that the DPF cooperates with the MYST domain to promote H3K9 and H3K14 acetylation, although not if H3K4 is trimethylated
MOZ/MYST3 complex associates with histone H3 with high affinity and specificity. Both proteins share a PHD finger domain.
The double PHD finger domain of MOZ/MYST3 induces a-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification.
In conclusion, our data show that Moz regulates H3K9 acetylation at Hox gene loci and that RA can act independently of Moz to establish specific Hox gene expression boundaries. The double PHD finger domain of MOZ/MYST3 induces a-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification
MOZ/MYST3 complex associates with histone H3 with PHD finger domain.
ere we report novel insights into histone H3 tail structure in complex with the double PHD finger (DPF) of the lysine acetyltransferase MOZ/MYST3/KAT6A.
ere we report novel insights into histone H3 tail structure in complex with the double PHD finger (DPF) of the lysine acetyltransferase MOZ/MYST3/KAT6A. In addition to sampling H3 and H4 modification status, we show that the DPF cooperates with the MYST domain to promote H3K9 and H3K14 acetylation, although not if H3K4 is trimethylated
In conclusion, our data show that Moz regulates H3K9 acetylation at Hox gene loci and that RA can act independently of Moz to establish specific Hox gene expression boundaries. The double PHD finger domain of MOZ/MYST3 induces a-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification ere we report novel insights into histone H3 tail structure in complex with the double PHD finger (DPF) of the lysine acetyltransferase MOZ/MYST3/KAT6A.
Question: The virus that causes FIP, Feline Infectious Peritonitis belongs to what family?
Answer: The virus that causes FIP, Feline Infectious Peritonitis belongs to the family coronavirus.
Feline coronavirus (fcov) is an etiological agent that causes a benign enteric illness and the fatal systemic disease feline infectious peritonitis (fip).
Feline coronavirus (FCoV) is an etiological agent that causes a benign enteric illness and the fatal systemic disease feline infectious peritonitis (FIP)
Feline Infectious Peritonitis (FIP) belongs to the family of coronavirus.
Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats.
Feline infectious peritonitis (FIP) is a common and highly lethal coronavirus disease of domestic cats
Feline Infectious Peritonitis virus (FIP) belongs to the coronavirus family of the genus Flavivirus which cause central nervous system disease.
Feline infectious peritonitis (FIP) is a cat virus caused by a member of the coronavirus family coronaviruses.
Question: Which cancer is associated with increased levels of Serum alpha fetoprotein (AFP) ?
Answer: Serum alpha fetoprotein (AFP) is a marker of germ cell neoplasms,
Serum α-Fetoprotein (AFP) is a widely used diagnostic biomarker, but it has limited sensitivity and is not elevated in all HCC cases.
Question: What is the target of Inebilizumab?
Answer: Inebilizumab is an anti-CD19 antibody with enhanced antibody-dependent cell-mediated cytotoxicity against B cells, is currently being evaluated in multiple sclerosis and neuromyelitis optica.
Question: What is the most common monogenic cause of common variable immunodeficiency (CVID) in Europeans?
Answer: Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans.
Heterozygous loss-of-function variants in NFKB1 are the most common known monogenic cause of common variable immunodeficiency (CVID), which results in a temporally progressive defect in the formation of immunoglobulin-producing B cells.
Question: What is the route of administration of vaxchora?
Answer: Vaxchora is an oral vaccine.
Question: What is iodine thyroid blocking?
Answer: High doses of potassium iodide are effective to block radioiodine thyroid uptake and to prevent development of thyroid cancer years later.
Question: What is a SERM?
Answer: A SERM is a Selective Estrogen Receptor Modulator.
selective estrogen receptor modulator (SERM),
elective estrogen receptor modulator (SERM),
elective estrogen receptor modulator (SERM),.
Question: What is the most likely age of diagnosis of Crohn's disease (CD)?
Answer: Crohn's disease has a bimodal age distribution of disease onset diagnosis. The peaks (20 and 50 years) may represent different phenotypes or different genetic and/or environmental influences between younger- and older-onset individuals. When the age-related incidence of Crohn's disease was plotted for all countries from which such data were available, the peaks of greatest case frequency occurred at ages 15 to 25 years and paralleled a similar peak representing the number of Peyer's patches as a function of age. For those with biologic use, average age at time of diagnosis of Crohn's disease was 32.3 ± 12.2 years, compared with 43.7 ± 16.3 years for those who had not received biologics (P = 0.005).
Question: What kind of molecule is AZD8601?
Answer: AZD8601 is a modified mRNA.
Question: What is the clinical indication of cardiac T1 mapping magnetic resonance?
Answer: T1 mapping can quantitatively characterize myocardial tissue, in particular diffuse and interstitial fibrosis, edema in both overt and subclinical cardiophyopathies. However more research is required before a large-scale application for clinical decision-making can be recommended.
The clinical indication of cardiac T1 mapping magnetic resonance is the detection  of diffuse myocardial fibrosis in nonischemic cardiomyopathies
Question: Where can you find the annulus of Zinn?
Answer: Annulus of Zinn is in the orbit.
Question: What is the cause of Sandhoff disease?
Answer: Sandhoff disease (SD) is a genetic disorder caused by a mutation of the β-subunit gene β-hexosaminidase B (HexB) in humans, which results in the massive accumulation of the ganglioside GM2 and related glycosphingolipids in the nervous system.
Question: What is the normal body temperature in dogs?
Answer: According to the American Kennel Club (AKC), a temperature of 101 to 102.5 degrees Fahrenheit (38.3 to 39.2 degrees Celsius) is typical for dogs
Question: Which resource has been developed in order to study the transcriptional regulation of GABAergic cell fate?
Answer: Subpallial Enhancer Transgenic Lines is a data and tool resource to study transcriptional regulation of GABAergic cell fate.
Question: Which epigenetic mark is deposited by PRC2?
Answer: H3K27me3 is the major histone methyltransferase activity of PRC2.
The Polycomb Repressive Complex 2 (PRC2) has been identified as a key regulator of epigenetic mark H3K27me3.
There are data showing coordinate regulation between DNAme and H3K27me3, which are both involved in the establishment and maintenance of epigenetic gene silencing. We found that the Polycomb Repressive Complex 2 (PRC2), which is responsible for di- and trimethylation of H3K27 (H3K27me2/me3), binds to its own site of methylation.
H3K27me3 is the endogenous epigenetic mark deposited by PRC2.
H3K27me3 is an epigenetic mark deposited by PRC2 (Polycomb repressive complex 2).
polycomb repressive complex 2 (prc2 ) mediates trimethylation of lysine 27 on histone h3
Polycomb repressive complex 2 (PRC2) trimethylates histone H3 at lysine 27, which establishes H3K27me3 repressive epigenetic marks that promote tissue-specific differentiation by silencing ectopic gene programs.
PRC2 is H3K27me3 ubiquitously-associated and acts as an epigenetic mark deposition mechanism.
Question: What type of genome, (RNA or DNA, double stranded single stranded) is found in the the virus that causes blue tongue disease?
Answer: The Bluetongue virus (BTV) genome contains ten double-stranded RNA segments.
Bluetongue virus (BTV) genome contains ten double-stranded RNA segments. 
Bluetongue virus (BTV) genome contains ten double-stranded RNA segments.
Bluetongue virus (BTV) genome contains ten double-stranded RNA segments
bluetongue virus (btv) genome contains ten double-stranded rna segments.
Question: What is the relationship between thyroid hormone and inflammatory markers in heart failure patients?
Answer: There is an inverse correlation between inflammatory markers (IL-6 and TNF alfa and PCR) and FT3 levels in patients with heart failure
Question: Which protein is the main marker of Cajal bodies?
Answer: Coilin is widely known as the protein marker of the Cajal body, a subnuclear domain important to the biogenesis of small nuclear ribonucleoproteins and telomerase, complexes that are crucial to pre-messenger RNA splicing and telomere maintenance, respectively The Cajal body has now regained the interest of biologists, due to the isolation of a protein marker, coilin.
Coilin is widely known as the protein marker of the Cajal body, a subnuclear domain important to the biogenesis of small nuclear ribonucleoproteins and telomerase, complexes that are crucial to pre-messenger RNA splicing and telomere maintenance, respectively Extensive studies have characterized the interaction between coilin and the various other protein components of CBs and related subnuclear domains; however, only a few have examined interactions between coilin and nucleic acid.
Coilin is widely known as the protein marker of the Cajal body, a subnuclear domain important to the biogenesis of small nuclear ribonucleoproteins and telomerase, complexes that are crucial to pre-messenger RNA splicing and telomere maintenance, respectively. The Cajal (coiled) body is a discrete nuclear organelle that was first described in mammalian neurons in 1903.
coilin
Coilin is widely known as the protein marker of the Cajal body, a subnuclear domain important to the biogenesis of small nuclear ribonucleoproteins and telomerase, complexes that are crucial to pre-messenger RNA splicing and telomere maintenance, respectively
Coilin, more than a molecular marker of the cajal (coiled) body The Cajal body has now regained the interest of biologists, due to the isolation of a protein marker, coilin.
Coilin is widely known as the protein marker of the Cajal body, a subnuclear domain important to the biogenesis of small nuclear ribonucleoproteins and telomerase, complexes that are crucial to pre-messenger RNA splicing and telomere maintenance, respectively.
Question: How are Arboviruses transmitted?
Answer: Arboviruses are transmitted by arthropods.
Question: What is the BioArchive system?
Answer: A small-scale automated cryopreservation and storage system (Mini-BioArchive system) used in the banking of umbilical cord blood (UCB) units.
Question: What syndrome is associated with mutations in lysine methyltransferase 2D KMT2D?
Answer: Mutations in lysine methyltransferase 2D (KMT2D) cause Kabuko syndrome.
Mutations in lysine methyltransferase 2D (KMT2D) gene, which encodes the catalytic core of a multisubunit chromatin remodeling enzyme, are responsible for the neurodegenerative disorder Kabuki syndrome.
Kabuki syndrome is a rare autosomal dominant disorder caused by mutations in the lysine methyltransferase 2D (KMT2D) gene.
Kabuki syndrome (KS) is commonly caused by mutations in the histone-modifying enzyme lysine methyltransferase 2D (KMT2D).
Mutations in the lysine methyltransferase 2D (KMT2D) gene, which encodes the alpha-subunit of the kappaB gene, are associated with the autosomal dominant hemophagocytic syndrome type 4 or Ferroportin syndrome.
Question: Which enzyme is targeted by Evolocumab?
Answer: Evolocumab (AMG145) is a fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9) that demonstrated marked reductions in plasma low-density lipoprotein cholesterol concentrations in statin-intolerant patients.
Question: Which is the effect of the HP1a protein on chromatin?
Answer: Heterochromatin Protein 1 (HP1a) is a well-known conserved protein that is involved in heterochromatin formation and gene silencing through the reading of the heterochromatin mark methylation of histone H3 lysine 9 (H3K9me) in different species including humans.
Heterochromatin-associated protein 1 (HP1a) mediates silencing and switching at the mating-type loci and is essential for pluripotency in Drosophila. HP1a belongs to a homologous family of histone-deacetyltransferases that mediate chromatin organization through the binding of histones to chromatin. The ATP-dependent chromatin-remodelling activity of HP1A is mediated, in part, by its interaction with histone H3 methyltransferase 3 (H3K9me2/3).