anand-s/m_qalm huggingface dataset:
Question: List four features of the WHIM syndrome.
Answer: The Warts, Hypogammaglobulinemia, Infections, Myelokathexis (WHIM) syndrome is an immunodeficiency caused by mutations in chemokine receptor CXCR4.
Question: List factors that promote lymphangiogenesis.
Answer: VEGF-C
VEGF-D
VEGF-R3
Question: List two indications of Letermovir?
Answer: Letermovir is approved for the prophylaxis of CMV infection and disease in adult CMV-seropositive recipients of an allogeneic haematopoietic stem cell transplant (HSCT).
Question: Which genes/proteins have been found to inhibit cyclin dependent kinase 4 (CDK4)?
Answer: The p15(ink4b) and p16(ink4a) CDK4 inhibitor genes map within the chromosome band 9p21 region deleted frequently in various cancers.The Cdk4 inhibitor p18(Ink4c) is a tumor suppressor. Recent studies of Cyclin D1/Cdk4 have proposed that p21(Waf1/Cip1/Sdi1) plays a key role as a potent Cdk4 inhibitor. p27KIP1 is also a cdk4 ihibitor.
Question: Which signaling pathways have been associated with medulloblastoma formation and growth?
Answer: Medulloblastoma comprises approximately 20% of all primary pediatric brain tumors. Multiple signaling pathways have been associated with disease formation and growth. These include the developmental pathways Hedgehog, Notch, and Wnt, as well as pathways in which the receptor tyrosine kinases (RTK) c-Met, erbB2, IGF-R and TrkC, and the oncoprotein Myc are involved.
Question: List clinical trials for prevention of sarcopenia
Answer: Several clinical trials with androgen replacement therapy. 
Study was to evaluate the effect of omega-3 fatty acid supplementation on the rate of muscle protein synthesis. This trial was registered at clinical trials.gov as NCT00794079
Question: Which are the common symptoms of Cushing's syndrome?
Answer: Cushing syndrome is the constellation of signs and symptoms caused by protracted exposure to glucocorticoids. Presenting features commonly include weight gain, growth retardation, hirsutism, obesity, striae, acne and hypertension.
Question: List features of the Currarino triad.
Answer: Currarino syndrome is a congenital malformation syndrome typically characterized by sacral agenesis, anorectal malformation, and presence of a pre-sacral mass.
Question: Which symptoms comprise Abdominal aortic aneurysm rupture Triad?
Answer: Classic triad of Abdominal aortic aneurysm rupture include shock, acute abdominal pain, and pulsatile abdominal mass.
Question: List the core SNARE complex proteins.
Answer: VAMP2
Syntaxin
SNAP25
Question: List polyubiquitin binding proteins involved in NF-kappaB signaling.
Answer: NEMO
A20
ABIN-1
ABIN-2
optineurin
p62
Question: Which are the inhibitors of histone methyltransferases?
Answer: In general, histone methyltransferases (HMTs) have no widely approved high-throughput screening assay format, and therefore reference inhibitors are not available for many of the HMTs. However, there are several selective HMT inhibitors: Trichostatin A (TSA), BIX-01294 and its derivative TM2-115, 2,4-pyridinedicarboxylic acid (2,4-PDCA), 3-deazaneplanocin A (DZNep), Psammaplin A (PsA) and Sulforaphane (SFN).
Question: List the human genes encoding for the dishevelled proteins?
Answer: DVL-1
DVL-2
DVL-3
Question: Which are the components of the pre-replication complex (pre-RC) in eukaryotes?
Answer: The components of the pre-replication complex (pre-RC) in eukaryotes are:
1) Cdc6/Cdc18, 
2) MCM, 
3) ORC1-6,
4) Cdt1 and
5) Sap1/Gi.
Question: List targets of classical analgesics.
Answer: Patient phenotypes in pharmacological pain treatment varies between individuals, which could be partly assigned to their genotypes regarding the targets of classical analgesics (OPRM1, PTGS2)
Question: List critical regions for 7p22.1 microduplication syndrome
Answer: 7p22.1 microduplication syndrome is mainly characterized by developmental and speech delay, craniofacial dysmorphism and skeletal abnormalities. The minimal critical region includes two OMIM genes: ACTB and RNF216.
Question: List critical regions for 7p22.1 microduplication syndrome
Answer: 7p22.1 microduplication syndrome is mainly characterized by developmental and speech delay, craniofacial dysmorphisms and skeletal abnormalities. The minimal critical region includes two OMIM genes: ACTB and RNF216.
Question: What are the five traits associated with metabolic syndrome?
Answer: Metabolic syndrome is the concurrent presentation of multiple cardiovascular risk factors, including obesity, insulin resistance, hyperglycemia, dyslipidemia and hypertension.
Question: What are the five traits associated with metabolic syndrome?
Answer: Metabolic syndrome is the concurrent presentation of multiple cardiovascular risk factors. These factors include obesity, insulin resistance, hyperglycemia, dyslipidemia and hypertension.
Question: What are the five traits associated with metabolic syndrome?
Answer: Metabolic syndrome is the concurrent presentation of multiple cardiovascular risk factors, including obesity, insulin resistance, hyperglycemia, dyslipidemia and hypertension
Question: What are the five traits associated with metabolic syndrome?
Answer: Metabolic syndrome is the concurrent presentation of multiple cardiovascular factors, including obesity, insulin resistance, type 1 diabetes, type 2 diabetes, and hypertension.
Question: What are the five traits associated with metabolic syndrome?
Answer: Metabolic syndrome is a cluster of conditions that occur together, increasing your risk of heart disease, stroke and type 2 diabetes. These conditions include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.
Question: What are the five traits associated with metabolic syndrome?
Answer: Metabolic syndrome (MetS) is a disorder of energy utilization and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity, insulin resistance, hypertension, dyslipidemia and hyperglycemia.
Question: What are the five traits associated with metabolic syndrome?
Answer: Metabolic syndrome is a disorder of energy utilization and storage, diagnosed by a co-occurrence of three out of five of the following medical conditions: abdominal (central) obesity, insulin resistance, hypertension, dyslipidemia and hyperglycemia.
Question: List the two most important synaptic markers.
Answer: postsynaptic density 95
synaptophysin
Question: List the two most important synaptic markers.
Answer: Synaptic markers include acetylcholine, gamma-aminobutyric acid (GABA), glutamine, glycine and synaptophysin.
Question: Which cell types are known to be driving Rheumatoid Arthritis?
Answer: Macrophages, T cells and their respective cytokines play a pivotal role in RA. Rheumatoid arthritis synovial fibroblasts (RASFs) constitute a quite unique cell type that distinguishes RA from other inflammatory conditions of the joints. Activated synovial fibroblasts (SFs) have the ability to invade joint cartilage, actively contributing to joint destruction in RA.
Question: Please list symptoms of measles.
Answer: The leading symptoms of the disease are high fever that presents after an incubation period of 9-10 days and the red rash that begins several days after the fever starts. Beyond specific generalized symptoms, measles may have ocular symptoms. The most commonly occuring satellite symptoms are conjunctivitis, coryza and cough.
Question: Which markers are screened with the triple test for the detection of syndromes in fetus?
Answer: The markers that are screened with the triple test for the detection of syndromes in fetus are:
1) alpha-fetoprotein (AFP), 
2) beta-chorionic gonadotrophin (beta-CG) and 
3) unconjugated oestriol (uE3).
Question: List core circadian clock genes.
Answer: The core circadian clock genes are CLOCK, BMAL1, Per, and Cry.
Question: Please list 7 classes of drugs that interact with Warfarin.
Answer: The number of drugs reported to interact with warfarin continues to expand. There are reports of interactions with azole antibiotics, macrolides, quinolones, nonsteroidal anti-inflammatory drugs, including selective cyclooxygenase-2 inhibitors, selective serotonin reuptake inhibitors, omeprazole, lipid-lowering agents, protease inhibitors, amiodarone, fluorouracil, psychotropics, and oral corticosteroids.
Question: Please list 7 classes of drugs that interact with Warfarin.
Answer: Seven drugs/drug classes (ibuprofen, morphine, warfarin, bupropion, paroxetine, rosiglitazone, ACE inhibitors) with known ADEs were selected to evaluate the system. This study was aimed to determine the prevalence of drug-related problems (DRPs), identify the most common drugs, and drug classes involved in DRPs as well as associated factors with the occurrence of DRPs.A prospective cross-sectional study was conducted on 225 patients admitted to medical wards of Tikur Anbessa Specialized Hospital, Addis Ababa from March to June 2014. Analysis of the data showed that albumin possesses a single strong binding site for warfarin with an association constant of 154,000 at 3 degrees C and secondary classes of several sites with a much lower affinity. Four medications or medication classes were implicated alone or in combination in 67.0% (95% CI, 60.0 to 74.1) of hospitalizations: warfarin (33.3%), insulins (13.9%), oral antiplatelet agents (13.3%), and oral hypoglycemic agents (10.7%). Drugs such as gentamycin, warfarin, nifedipine, and cimetidine have the highest probability of causing DRP. Drugs with the highest drug risk ratio were gentamycin, warfarin, nifedipine, and cimetidine. The drugs most frequently causing a DRP were angiotensin-converting enzyme inhibitors/angiotensin II receptor blockers, diuretics, warfarin, spironolactone, and β-blockers.
Question: List metalloenzyme inhibitors.
Answer: Foscarnet
VT-1129
VT-1161 
BB-3497
hydroxamate molecules
siderophores
Question: List symptoms of Heerfordt syndrome.
Answer: Heerfordt syndrome (also known as Heerfordt-Waldenström or uveoparotid fever)  is a rare presentation of sarcoidosis characterized by the presence of parotid gland enlargement, facial palsy, anterior uveitis, and fever.
Question: List symptoms of Gradenigo's syndrome.
Answer: Gradenigo's syndrome is a rare but life threatening complication of acute otitis media, which includes a classic triad of otitis media, deep facial pain and ipsilateral abducens nerve paralysis.
Question: List programs suitable for protein docking
Answer: Macromolecular docking is the computational modelling of the quaternary structure of complexes formed by two or more interacting biological macromolecules. Protein–protein complexes are the most commonly attempted targets of such modelling, followed by protein–nucleic acid complexes.
The ultimate goal of docking is the prediction of the three-dimensional structure of the macromolecular complex of interest as it would occur in a living organism. Docking itself only produces plausible candidate structures. These candidates must be ranked using methods such as scoring functions to identify structures that are most likely to occur in nature.
Nowadays there a lot of programs suitable for proteins docking  such as CSBB-ConeExclusion, HADDOCK, ZDOCK, GalaxyDock, PHASE, DockRank, HotLig, SOL, AutodockVina, DockoMatic, DockoMatic, DockTrina, CAVITY, LiGenDock and DOCK.
Question: What is included in the Mentzer index?
Answer: Mentzer index (MCV/RBC) is mean corpuscular volume (MCV) and red blood cell count (RBC) ratio. It is used for differentiation of thalassemia and iron deficiency anemia.
Question: Mutations in which genes have been associated with Aicardi-Goutieres syndrome?
Answer: Aicardi-Goutières syndrome (AGS) is an inflammatory disorder caused by mutations in any of six genes (TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR).
Question: Which forms of cancer is the Tpl2 gene associated with?
Answer: Tpl2/Map3K8, also known as tumor progression locus 2 has been identified as an oncogene, its mutation or overexpression is reported in a variety of human cancers. Types of cancer associated with Tpl2 include skin and epithelial cancers, ADI prostate cancer, gastric and colon adenocarcinomas, colitis-associated cancer (CAC), breast cancer, Hodgkin lymphomas, nasopharyngeal carcinomas and several types of T-cell neoplasias.
Question: List mediators that are released from mast cells?
Answer: tryptase
histamine
heparin proteoglycan
chymase
cytokines
2,3-dinor-11β-PGF2α
leukotriene (LT)E4
Question: What is being measured with an accelerometer in back pain patients
Answer: Accelerometer assessment measuring overall physical activity (PAL), constant strain postures (CSP), standing time (ST) and lying time (LT)...
The following parameters of physical activity were recorded: time upright (standing or walking), time standing, time walking, and step count.
Question: Which disease can be treated with Relugolix.
Answer: Relugolix has a role in treatment of prostate cancer, uterine fibroids, endometriosis and uterine myomas.
Question: Which agents are included in the FLAMSA chemotherapy regimen?
Answer: Fludarabine, cytarabine and amsacrine are included in the FLAMSA chemotherapy regimen.
Question: List major features of TEMPI Syndrome.
Answer: TEMPI syndrome includes telangiectasias, erythrocytosis with elevated erythropoietin, monoclonal gammopathy, perinephric fluid collections, intrapulmonary shunting. It is a newly described clinical entity that is generally considered a plasma cell dyscrasia with multiple system involvement.
Question: What is the active ingredient in the most common hand sanitizer?
Answer: Evaluation of a benzalkonium chloride hand sanitizer in reducing transient Staphylococcus aureus bacterial skin contamination in health care workers.
Question: What is the active ingredient in the most common hand sanitizer?
Answer: The active ingredient in the most common hand sanitizer is ethanol, benzalkonium chloride, isopropanol, alcohol, bzk, 70% ethanol.
Question: What is the active ingredient in the most common hand sanitizer?
Answer: The active ingredients in most hand sanitizers include ethanol, benzalkonium chloride, isopropanol, alcohol, bzk, 70% ethanol and soap.
Question: What is the active ingredient in the most common hand sanitizer?
Answer: The active ingredient is isopropyl alcohol, which is an alcohol-based hand sanitizer.
Question: What is the active ingredient in the most common hand sanitizer?
Answer: While there is a new commercially available hand sanitizer using 0.12% benzalkonium chloride (BZK) as the active ingredient in hand sanitizer, most hand sanitizers are 70-80% ethanol-based or 75% isopropanol
Question: List the 6 genes associated with the autosomal recessive form of Osteogenesis imperfecta
Answer: There are at least 6 genes associated with osteogenesis imperfecta, Sp7/Osx, FK506-binding protein, Hsp47/SERPINH1, WNT1, CRTAP, P3H1, and PPIB, LEPRE1,PLOD2, TMEM38B
Question: List 3 features of IRVAN syndrome.
Answer: Idiopathic retinal vasculitis, aneurysms, and neuroretinitis is coined as IRVAN syndrome.
Question: The protein neprilysin  has an positive effect on Alzheimer disease, how can it be delivered to the brain?
Answer: The protein neprilysin can be deliverered to the brain (crossing the blood brain barrier) through: gene tranfer, transgenesis, gene induction, ex-vivo gene therapy, intracardiac (peripheral) administration of viral neprilysin construct, syringe-focused ultrasound device, convection-enhanced delivery and the use of human adipose tissue-derived mesenchymal stem cells that secrete functional neprilysin-bound exosomes
Question: List 3 NK3R antagonists.
Answer: NK3 receptor antagonists include MLE4901 (also known as AZD4901), SB222200 and ESN364.
Question: List 3 indications for Bupropion
Answer: Bupropion is used to treat Obesity, for smoking cessation and for depression
Question: List Mcl-1 inhibitors.
Answer: A-1210477
S63845
Question: Name 3 diseases for which lucatumumab is being tested?
Answer: Lucatumumab is being tested as treatment for malignancies such as chronic lymphatic leukemia (CLL), Multiple Myeloma (MM), and non-Hodgkin's lymphoma (NHL).
Question: Which methods infer 3D genome structure without proximity ligation?
Answer: SPRITE is a method that enables genome-wide detection of higher-order interactions within the nucleus.
Transposase-mediated analysis of chromatin looping (Trac-looping) for simultaneous detection of multiscale genome-wide chromatin interactions among regulatory elements and chromatin accessibility.
Genome architecture mapping (GAM) can be used for measuring chromatin contacts and other features of three-dimensional chromatin topology on the basis of sequencing DNA from a large collection of thin nuclear sections.
Question: Which methods infer 3D genome structure without proximity ligation?
Answer: To investigate three-dimensional (3D) genome organization in prokaryotic and eukaryotic cells, three main strategies are employed, namely nuclear proximity ligation-based methods, imaging tools (such as fluorescence in situ hybridization (FISH) and its derivatives), and computational/visualization methods.
Question: Which methods infer 3D genome structure without proximity ligation?
Answer: Proximity ligation assays commonly known as chromosome conformation capture (3C) and 3C based methodologies (e.g., GCC, HiC and ChIA-Pet) are increasingly being incorporated into empirical studies to investigate the role that three-dimensional genome structure plays in the regulation of phenotype. By combining 3C and high-throughput sequencing, the Hi-C method reveals genome-wide interactions within topological domains and global genome structure as a whole. Here we report a genome-wide method, genome architecture mapping (GAM), for measuring chromatin contacts and other features of three-dimensional chromatin topology on the basis of sequencing DNA from a large collection of thin nuclear sections. We describe a genome architecture assay, tethered multiple 3C (TM3C), that maps genome-wide chromatin contacts via a simple protocol of restriction enzyme digestion and religation of fragments upon agarose gel beads followed by paired-end sequencing. Using SPRITE, we recapitulate known structures identified by proximity ligation and identify additional interactions occurring across larger distances, including two hubs of inter-chromosomal interactions that are arranged around the nucleolus and nuclear speckles. We now report transposase-mediated analysis of chromatin looping (Trac-looping) for simultaneous detection of multiscale genome-wide chromatin interactions among regulatory elements and chromatin accessibility.
Question: Which methods infer 3D genome structure without proximity ligation?
Answer: Proximity ligation assays commonly known as chromosome conformation capture (3C) and 3C based methodologies (e.g., GCC, HiC and ChIA-Pet) are increasingly being incorporated into empirical studies to investigate the role that three-dimensional genome structure plays in the regulation of phenotype. By combining 3C and high-throughput sequencing, the Hi-C method reveals genome-wide interactions within topological domains and global genome structure as a whole. Here we report a genome-wide method, genome architecture mapping (GAM), for measuring chromatin contacts and other features of three-dimensional chromatin topology on the basis of sequencing DNA from a large collection of thin nuclear sections. We describe a genome architecture assay, tethered multiple 3C (TM3C), that maps genome-wide chromatin contacts via a simple protocol of restriction enzyme digestion and religation of fragments upon agarose gel beads followed by paired-end sequencing. Using SPRITE, we recapitulate known structures identified by proximity ligation and identify additional interactions occurring across larger distances, including two hubs of inter-chromosomal interactions that are arranged around the nucleolus and nuclear speckles.
Question: In which tissues is the lincRNA Xist expressed?
Answer: Relative expression of X-linked genes was examined in liver, kidney and brain tissue by real-time PCR in adult XX(Y)* and XY* males and XX females. X-chromosome inactive specific transcript (Xist) was expressed only in female adipose tissue. X-chromosome inactive specific transcript (Xist) was expressed only in female adipose tissue. It was also expressed in duodenum and testis.
Question: List the cancers that are associated with SBLA syndrome.
Answer: Li-Fraumeni syndrome is an autosomal dominant inherited disorder also known as the SBLA cancer syndrome (sarcoma, breast, leukemia, and adrenal). Li-Fraumeni syndrome (LFS) is characterized by a pleth
Question: List the cancers that are associated with SBLA syndrome.
Answer: SBLA cancer syndrome (sarcoma, breast, leukemia, and adrenal).
Question: List the cancers that are associated with SBLA syndrome.
Answer: Li-Fraumeni syndrome is an autosomal dominant inherited disorder also known as the SBLA cancer syndrome (sarcoma, breast, brain, lung, lymphoma, leukemia, laryngeal and adrenal).
Question: Which curated databases exist for spider-venom toxins?
Answer: ArachnoServer and its updated version ArachnoServer 2.0 are manually curated databases providing information on the sequence, structure and biological activity of protein toxins from spider venoms.
Question: Name 4 side effects of enasidenib
Answer: Enasidenib is found to be associated with certain adverse effects like elevated bilirubin level, diarrhea, differentiation syndrome, decreased potassium and calcium levels etc.
Question: Which diseases can Oncotype DX be used for?
Answer: Oncotype can be used for predicting breast cancer and colon cancer recurrence.
Question: List disorders that are caused by mutations in the mitochondrial MTND6 gene.
Answer: Mitochondrial MTND6 gene mutations are the cause of Leigh syndrome and Leber's hereditary optic neuropathy and/or dystonia.
Question: List disorders that have been associated to the polymorphism rs2535629.
Answer: schizophrenia and major depressive disorder.
Question: Which molecules are targeted by Trastuzumab Deruxtecan?
Answer: Trastuzumab deruxtecan is a HER2-directed antibody and DNA topoisomerase I inhibitor conjugate being developed for the treatment of HER2-expressing solid tumours, including breast cancer, gastric cancer, colorectal cancer and non-small cell lung cancer
Question: List BET proteins.
Answer: BRD2
BRD3
BRD4
Bdf1
Question: Which chromosomes are implicated in the Emanuel syndrome?
Answer: Emanuel syndrome is associated with supernumerary chromosome t(11;22)(q23;q11), which consists of the extra genetic material from chromosomes 11 and 22.
Question: Which organs are primarily damaged in SLE?
Answer: The patients with SLE are mostly affected by renal, peripheral vascular, musculoskeletal and neurological damage. The skin and heart are also damaged very frequently.
Question: Which organs are primarily damaged in SLE?
Answer: In systemic lupus erythematosus (SLE), brain and kidney are the most frequently damaged organs. The heart is one of the most commonly damaged organs in SLE. Any part of the heart can be affected, including the pericardium, myocardium, coronary arteries, valves, and the conduction system
Question: Abnormalities in which chromosomes were linked to the Moyamoya disease?
Answer: chromosomes 3, 6, 8, 12, 15, 17, 21, X and Y were implicated in the Moyamoya disease.
Question: Which variables are included in the SPAN-100 score?
Answer: SPAN-100 score includes patient's age and NIH Stroke Scale score. SPAN-100 is used for prognostication of stroke patients.
Question: Which hormone abnormalities are common in Williams syndrome
Answer: Elevated Thyrotropin - TSH
Low FT4
Growth Hormone deficiency
Calcitonin deficiency
Elevated Prolactin
Elevated Cortisol
Elevated Oxytocin
Elevated Vasopressin