anand-s/m_qalm huggingface dataset:
Question: Which is the most common gene signature in Rheumatoid Arthritis patients?
Answer: a five gene type i ifn signature was assessed in these subjects to identify subpopulations showing both activation and concordance of the type i ifn pathway in the peripheral blood and disease-affected tissues of each disease and to correlate activation of this pathway in the wb with clinical measurements.
Question: Which is the most common gene signature in Rheumatoid Arthritis patients?
Answer: A five gene type I IFN signature was assessed in these subjects to identify subpopulations showing both activation and concordance of the type I IFN pathway in the peripheral blood and disease-affected tissues of each disease and to correlate activation of this pathway in the WB with clinical measurements.R
Question: Which software package is available for the analysis of conserved genomic loci?
Answer: PHYLUCE is a software package for the analysis of conserved genomic loci. It identifies targeted, enriched loci from the off-target background data; aligns enriched contigs representing conserved loci to one another; and prepare and manipulate these alignments for subsequent phylogenomic inference. PHYLUCE is an efficient and easy-to-install software package that accomplishes these tasks across hundreds of taxa and thousands of enriched loci
Question: Which software package is available for the analysis of conserved genomic loci?
Answer: PHYLUCE is a software package for the analysis of conserved genomic loci
Question: Which translocation is harbored in the Askin tumor cells?
Answer: The Askin tumor is a primitive malignant small-cell tumor of the chest wall mostly seen among children and adolescents. It is closely related to Ewing's sarcoma of the same location, with both tumors harboring reciprocal translocation t(11;22) (q24;q12).
Question: When is serum AFP used as marker?
Answer: Serum α-Fetoprotein (AFP) is a widely used diagnostic biomarker, but it has limited sensitivity and is not elevated in all Hepato cellular carcinoma (HCC) cases so, we incorporate a second blood-based biomarker, des'γ carboxy-prothrombin (DCP), that has shown potential as a screening marker for HCC.
Question: Galassi classification is used for which disorder?
Answer: Galassi classification system is used to classify arachnoid cysts.
Question: What drug cures hepatitis C?
Answer: Sofosbuvir-based therapy cures hepatitis C virus infection
Question: What is the prognostic role of alterred thyroid profile after cardiosurgery?
Answer: Altered thyroid profile after cardiosurgery is associated with high incidence of atrial fibrillation e delay in recovery (prolonged hospitalisation) in adults and higher score on The Pediatric Risk of Mortality (PRISM; P < 0.042) and a longer duration of ventilation in children.Impportantly in transplanted patients altered thyroid metabolism,low T3 syndrome, is characterized by highest mortality, highest incidence of acute rejection or reoperations and infections
Question: What is FeatureCounts used for?
Answer: featureCounts is a general purpose program for assigning sequence reads to genomic features. It is a read summarization program suitable for counting reads generated from either RNA or genomic DNA sequencing experiments.
Question: What is FeatureCounts used for?
Answer: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. We present featureCounts, a read summarization program suitable for counting reads generated from either RNA or genomic DNA sequencing experiments
Question: What is FeatureCounts used for?
Answer: featureCounts can be used to quantify reads generated from either RNA or DNA sequencing technologies in terms of any type of genomic feature. It implements chromosome hashing, feature blocking and other strategies to assign reads to features with high efficiency.
Question: What is FeatureCounts used for?
Answer: Featurecounts is a system that uses a novel Bayesian approach to calculate informative metrics at each depth required to inform a broad range of functional and evolutionary studies. The database is optimized to support fast interactive performance with the RNA-Seq platform.
Question: What is FeatureCounts used for?
Answer: featureCounts: an efficient general purpose program for assigning sequence reads to genomic features.
Question: What is FeatureCounts used for?
Answer: We present featureCounts, a read summarization program suitable for counting reads generated from either RNA or genomic DNA sequencing experiments.
Question: What histone modification is recognized by the bromodomain?
Answer: Acetylated lysines in histones (generally H3 and H4)
Question: Which individuals show preferential colonization of the Prevotellaceae bacteria in their guts?
Answer: Although the distinction of enterotypes as either discrete clusters or a continuum will require additional investigation, numerous studies have demonstrated the co-exclusion of the closely related Prevotellaceae and Bacteroides genera in the gut microbiota of healthy human subjects where Prevotella appears to be a discriminatory taxon for residence in more agrarian societies.
Question: What is the gold standard treatment for Iatrogenic male incontinence?
Answer: The artificial urethral sphincter has represented, until today, the gold standard but, in the recent years, sling systems have been investigated as minimally invasive alternative options.
Question: The formation of which inflammatory molecule is regulated by MAP3K8 (TPL2)?
Answer: MAP3K8 (Tpl2) regulates the formation of inflammatory molecule IL-1β
Question: The formation of which inflammatory molecule is regulated by MAP3K8 (TPL2)?
Answer: MAP3K8 (Tpl2) regulates the formation of IL-1β by masking its inflammatory function.
Question: The formation of which inflammatory molecule is regulated by MAP3K8 (TPL2)?
Answer: MAP3K8 (also known as Map3k8) regulates the formation of IL-1β
Question: The formation of which inflammatory molecule is regulated by MAP3K8 (TPL2)?
Answer: IL-1β formation is regulated by MAP3K8 (TPL2)
Question: The formation of which inflammatory molecule is regulated by MAP3K8 (TPL2)?
Answer: Tpl2 as an important mediator for collaboration of pattern recognition receptors with danger-associated molecular patterns to induce TNF and IL-1beta production and optimal host defense.
Question: The formation of which inflammatory molecule is regulated by MAP3K8 (TPL2)?
Answer: MAP3K8 is involved in local adipose tissue inflammation, specifically for IL-1β and its responsive cytokines IL-6 and IL-8, but does not seem to have systemic effects on insulin resistance.
Question: Which is the most common type of pediatric cerebellar tumor?
Answer: Medulloblastoma is the most common malignant cerebellar tumor seen in the pediatric age group, which has a known ability to metastasize extraneurally.
Question: Which is the most common type of pediatric cerebellar tumor?
Answer: Medulloblastoma is a malignant cerebellar tumor seen primarily in the pediatric age group that has a known ability to metastasize extraneurally
Question: Which algorithm has been developed for finding conserved non-coding elements (CNEs) in genomes?
Answer: CNEFinder is a tool for identifying CNEs between two given DNA sequences with user-defined criteria.
Question: Pridopidine has been tested for treatment of which disorder?
Answer: Pridopidine is a dopaminergic stabilizer that has shown promising results for treatment of Huntington disease patients.
Question: What is the indication for SLCO1B1 genotyping?
Answer: HMG Co-A reductase inhibitors, commonly known as statins, also display wide interindividual variability in plasma concentration, response and toxicity due in part to polymorphisms in transporter genes, including SLCO1B1 and ABCG2.  The SLCO1B1*5 variant is a risk factor for statin side effects and exhibits statin-specific effects: highest with simvastatin/atorvastatin and lowest with pravastatin/rosuvastatin.
Question: What does davunetide do to microtubules?
Answer: Davunetide or NAP is a microtubule-stabilizer.
Question: What is the clathrin triskelia structure?
Answer: The clathrin triskelion, which is a three-legged pinwheel-shaped heteropolymer, is a major component in the protein coats of certain post-Golgi and endocytic vesicles.
Question: Where in the cell does the proteins S100A4 and p53 interact ?
Answer: S100A4 interacts with p53 in the cell nucleus.
Question: What is caused by heterozygous lamin B1 and lamin B2 variants?
Answer: Heterozygous lamin B1 and lamin B2 variants cause primary microcephaly and define a novel laminopathy.
Question: What is caused by heterozygous lamin B1 and lamin B2 variants?
Answer: Heterozygous lamin B1 and Lamin B2 variants cause primary microcephaly and define a novel laminopathy.
Question: What is caused by heterozygous lamin B1 and lamin B2 variants?
Answer: Microcephaly is a rare autosomal recessive disorder caused by heterozygous lamin B1 and Lamin B2 variants.
Question: What is caused by heterozygous lamin B1 and lamin B2 variants?
Answer: Heterozygous lamin B1 and Lamin B2 variants cause primary microcephaly and define a novel laminopathy
Question: What is caused by heterozygous lamin B1 and lamin B2 variants?
Answer: Heterozygous lamin B1 and laminB2 variants cause primary microcephaly and define a novel laminopathy.
Question: Does the HercepTest use a polycloncal or monoclonal antibody?
Answer: The HercepTest uses a polyclonal antibody.
Question: Which is the most important prognosis sub-classification in Chronic Lymphocytic Leukemia?
Answer: The mutational status of the immunoglobulin heavy variable (IGHV) genes, defines two subsets: mutated and unmutated CLL. Unmutated CLL patients show a shorter progression-free and overall survival than mutated CLL patients.
Question: In which phase of the cell cycle arrest is impaired in Fanconi anemia?
Answer: In response to damage induced by DNA cross-linking agents, the S-phase checkpoint is inefficient in Fanconi anemia (FA) cells, leading to accumulation of secondary lesions, such as single- and double-strand breaks and gaps. The prolonged time in G2 phase seen in FA cells therefore exists in order to allow the cells to remove lesions which accumulated during the preceding abnormal S phase.
Question: How many genes constitute the DosR regulon, controlled by the dormancy survival regulator (DosR) in Mycobacterium tuberculosis?
Answer: The Mycobacterium dormancy survival regulator (DosR) regulon is composed of 48 co-regulated genes.
Question: How many genes constitute the DosR regulon, controlled by the dormancy survival regulator (DosR) in Mycobacterium tuberculosis?
Answer: During this phase, at least 48 genes, collectively named Dormancy survival regulator (DosR) regulon, are important for the long-term survival of bacilli under a non-respiring state, a condition that bacilli encounter inside granulomatous lesions.  DosR/DevR of M. tuberculosis is a two component dormancy survival response regulator which induces the expression of 48 genes.
Question: How many genes constitute the DosR regulon, controlled by the dormancy survival regulator (DosR) in Mycobacterium tuberculosis?
Answer: During this phase, at least 48 genes, collectively named Dormancy survival regulator (DosR) regulon, are important for the long-term survival of bacilli under a non-respiring state, a condition that bacilli encounter inside granulomatous lesions. The dormancy survival regulator (DosR) regulon, composed of 48 co-regulated genes, is held as essential for Mtb persistence.
Question: How many genes constitute the DosR regulon, controlled by the dormancy survival regulator (DosR) in Mycobacterium tuberculosis?
Answer: The dormancy survival regulator  regulon, composed of 48 co-regulated genes, is held as essential for Mtb persistence. The two component sensor/regulator dosRS is a major mediator in the transcriptional response of M. tuberculosis to hypoxia and controls a regulon of approximately 50 genes that are induced under this condition.
Question: How many genes constitute the DosR regulon, controlled by the dormancy survival regulator (DosR) in Mycobacterium tuberculosis?
Answer: During this phase, at least 48 genes, collectively named Dormancy survival regulator (DosR) regulon, are important for the long-term survival of bacilli under a non-respiring state, a condition that bacilli encounter inside granulomatous lesions.
Question: How many genes constitute the DosR regulon, controlled by the dormancy survival regulator (DosR) in Mycobacterium tuberculosis?
Answer: The dormancy survival regulator (DosR) regulon, composed of 48 co-regulated genes, is held as essential for Mtb persistence. During this phase, at least 48 genes, collectively named Dormancy survival regulator (DosR) regulon, are important for the long-term survival of bacilli under a non-respiring state, a condition that bacilli encounter inside granulomatous lesions.
Question: Which protein is mutated in Erythropoietic Protoporphyria?
Answer: Erythropoietic protoporphyria (EPP) is a rare inherited disorder of the heme biosynthesis pathway resulting in the accumulation of protoporphyrins in the blood, erythrocytes, and other tissues. Because of a gene mutation in the FECH gene, ferrochelatase, the enzyme involved in the final step of heme synthesis, is deficient in these patients.
Question: Which molecule is targeted by the drug Gevokizumab?
Answer: Gevokizumab is an allosteric anti-IL-1β monoclonal antibody.
Question: Oxantel is used for periodontitis treatment. How does it work?
Answer: Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms.
Question: What disease is the drug aducanumab targeting?
Answer: Aducanumab is an anti-Aβ antibody being developed for the treatment of Alzheimer's disease (AD).
Question: Which method is behind HipMCL?
Answer: HipMCL is a high-performance parallel implementation of the Markov clustering algorithm for large-scale networks. Despite its popularity, MCL's scalability to cluster large datasets still remains a bottleneck due to high running times and memory demands.
Question: Which method is behind HipMCL?
Answer: While various clustering algorithms have been proposed to find highly connected regions, Markov Clustering (MCL) has been one of the most successful approaches to cluster sequence similarity or expression networks. HipMCL is based on MPI and OpenMP and is freely available under a modified BSD license.
Question: Which method is behind HipMCL?
Answer: While various clustering algorithms have been proposed to find highly connected regions, Markov Clustering (MCL) has been one of the most successful approaches to cluster sequence similarity or expression networks. Despite its popularity, MCL's scalability to cluster large datasets still remains a bottleneck due to high running times and memory demands. High-performance MCL (HipMCL) offers a parallel implementation of the original MCL algorithm that can run on distributed-memory computers. By exploiting distributed-memory environments, HipMCL clusters large-scale networks several orders of magnitude faster than MCL and enables clustering of even bigger networks. HipMCL is based on MPI and OpenMP and is freely available under a modified BSD license.
Question: Which method is behind HipMCL?
Answer: While various clustering algorithms have been proposed to find highly connected regions, Markov Clustering (MCL) has been one of the most successful approaches to cluster sequence similarity or expression networks. Despite its popularity, MCL's scalability to cluster large datasets still remains a bottleneck due to high running times and memory demands. HipMCL is a high-performance parallel implementation of the Markov clustering algorithm for large-scale networks.
Question: Which method is behind HipMCL?
Answer: HipMCL (HipClustering) is a high-performance parallel implementation of the Markov clustering algorithm for large-scale networks.
Question: Which method is behind HipMCL?
Answer: HipMCL is a high-performance parallel implementation of the Markov clustering algorithm for large-scale networks.
Question: What does MVA85A stand for?
Answer: MVA85A is the Modified Vaccinia virus Ankara expressing Antigen 85A.
Question: What histone trimethylation has been associated to RNA splicing?
Answer: Mostly H3K36me3 but there is some evidence that H3K4me3 may also play a role in splicing
Question: Which metabolite activates AtxA?
Answer: Upon infection of a mammalian host, Bacillus anthracis responds to host cues, and particularly to elevated temperature (37°C) and bicarbonate/CO2 concentrations, with increased expression of virulence factors that include the anthrax toxins and extracellular capsular layer. Cultures grown with elevated CO(2) /bicarbonate exhibited increased AtxA dimer/monomer ratios and increased AtxA activity, relative to cultures grown without added CO(2) /bicarbonate, suggesting that this host-associated signal enhances AtxA function by shifting the dimer/monomer equilibrium towards the dimeric state. CO2-enhanced toxin gene transcription is not observed in atx4-null mutants. Overall data indicate a clear association of atxA with CO2-enhanced gene expression in B. anthracis and provide evidence that atxA regulates genes other than the structural genes for the anthrax toxin proteins.
Question: Which metabolite activates AtxA?
Answer: Comparison of the resulting protein patterns indicated that synthesis of non-toxin proteins is influenced by growth in elevated CO2 and the toxin gene regulator, atxA. The Bacillus anthracis toxin genes, cya, lef, and pag, can be viewed as a regulon, in which transcription of all three genes is activated in trans by the same regulatory gene, atxA, in response to the same signal, CO2. However, the steady-state level of atxA mRNA in cells grown in elevated CO2/bicarbonate at 37 degrees C is five- to sixfold higher than that observed in cells grown in the same conditions at 28 degrees C. A corresponding difference in AtxA protein was also seen at the different growth temperatures. All mutants multimerized, but one mutation, C402S, prevented cross-linking.
Question: What drug treatment can cause a spinal epidural hematoma?
Answer: Spinal epidural hematoma (SEH) is a rare disease that causes cord compression and neurologic deficit. Spontaneous SEH is related to minor trauma, bleeding disorders, and anticoagulant medications.
Question: What drug treatment can cause a spinal epidural hematoma?
Answer: Spinal epidural hematomas are rare entity in neurosurgery practice. Most of them are spontaneous due to anticoagulant therapy and called spontaneous spinal epidural hematomas (SSEHs).
Question: What drug treatment can cause a spinal epidural hematoma?
Answer: Spinal epidural hematoma (SEH) is a rare disease that causes cord compression and neurologic deficit.pinal subdural hematoma associated with antiplatelet therapy
Question: What is the name for anorexia in gymnasts?
Answer: Anorexia athletica
Question: What is the role of the IRE1a-XBP1 pathway?
Answer: The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response, playing an important role in the regulation of cell differentiation.
Question: What is the role of the IRE1a-XBP1 pathway?
Answer: The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response, playing an important role in the regulation of cell proliferation and differentiation.
Question: What is the role of the IRE1a-XBP1 pathway?
Answer: The inositol-requiring enzyme 1a (IRE1a)/X-box binding protein 1 (XBP1) pathway plays crucial roles in cell survival and cell death by upregulating UPR-associated genes involved in protein entry into the endoplasmic reticulum  and ER-associated degradation (ERAD).
Question: What is the role of the IRE1a-XBP1 pathway?
Answer: The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfold protein response.
Question: What is the role of the IRE1a-XBP1 pathway?
Answer: The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. The pathway is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity.
Question: What is the role of the IRE1a-XBP1 pathway?
Answer: The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response.
Question: What is the role of the IRE1a-XBP1 pathway?
Answer: Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation.
Question: What is the role of the IRE1a-XBP1 pathway?
Answer: The IRE1a-XBP1 pathway is a conserved adaptive mediator of the unfolded protein response. It is indispensable for the development of secretory cells by facilitating protein folding and enhancing secretory capacity.
Question: Which is the main ligand for the glucocorticoid receptor?
Answer: Glucocorticoids (GC) such as cortisol regulate multiple physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene in humans).
Question: Which are the coactivators of the Yes-associated protein (yap)?
Answer: The Yap protein forms complex with Tead (TEA domain) transcription factors.
Question: What is another name for the drug AMG334?
Answer: AMG334 is also called erenumab.
Question: Which disease is associated with the ectopic expression of the protein encoded by the gene DUX4?
Answer: Facioscapulohumeral dystrophy (FSHD) is a progressive muscular dystrophy caused by decreased epigenetic repression of the D4Z4 macrosatellite repeats and ectopic expression of DUX4, a retrogene encoding a germline transcription factor encoded in each repeat.
Question: Which protein has been found to interact with phospholamban (PLN) and is also an anti-apoptotic protein?
Answer: Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function.The discovery of the PLN/HAX-1 interaction therefore unveils an important new link between Ca(2+) homeostasis and cell survival, with significant therapeutic potential.
Question: Which protein has been found to interact with phospholamban (PLN) and is also an anti-apoptotic protein?
Answer: The HS-1 associated protein X-1 (HAX-1) is a mitochondrial protein with anti-apoptotic function and presents with numerous similarities to Bcl-2. and was identified as a phospholamban-binding partner. Using the yeast-two-hybrid system, HS-1 associated protein X-1 (HAX-1) was identified as a PLN-binding partner.
Question: Which protein has been found to interact with phospholamban (PLN) and is also an anti-apoptotic protein?
Answer: The sarco(endo)plasmic reticulum (SR) Ca(2+) transport ATPase (SERCA2a) and its inhibitor phospholamban (PLN) control the uptake of Ca(2+) by SR membranes during relaxation. Recently, the antiapoptotic HS-1-associated protein X-1 (HAX-1) was identified as a binding partner of PLN, and this interaction was postulated to regulate cell apoptosis.Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function.
Question: How is oprozomib administered?
Answer: Oprozomib is administered orally.
Question: What is the function of circular RNA?
Answer: Circular RNAs (circRNAs) are a novel type of RNA that, unlike linear RNAs, form a covalently closed continuous loop and are highly represented in the eukaryotic transcriptome. The biogenesis of circular RNA is an integral, conserved, and regulated feature of the gene expression program. Circular RNAs play a crucial role in fine tuning the level of miRNA mediated regulation of gene expression by sequestering the miRNAs. Recent research has revealed that circRNAs can function as microRNA (miRNA) sponges, regulators of splicing and transcription, and modifiers of parental gene expression.