TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic, Persistent, Recurrent, or Progressive Solid Tumors
Status: TERMINATED
Study type: INTERVENTIONAL
Conditions: Colorectal Adenocarcinoma|Metastatic Pancreatic Adenocarcinoma|Recurrent Breast Carcinoma|Recurrent Colorectal Carcinoma|Recurrent Melanoma of the Skin|Recurrent Non-Small Cell Lung Carcinoma|Recurrent Pancreatic Carcinoma|Recurrent Renal Cell Carcinoma|Solid Neoplasm|Stage IV Breast Cancer|Stage IV Non-Small Cell Lung Cancer|Stage IV Renal Cell Cancer|Stage IV Skin Melanoma|Stage IVA Colorectal Cancer|Stage IVA Pancreatic Cancer|Stage IVB Colorectal Cancer|Stage IVB Pancreatic Cancer
Interventions: DRUG: Cyclophosphamide|OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Pegfilgrastim|OTHER: Pharmacological Study|DRUG: TLR8 Agonist VTX-2337
Sponsor: Mayo Clinic
Collaborators: National Cancer Institute (NCI)