RO4929097 and Whole-Brain Radiation Therapy or Stereotactic Radiosurgery in Treating Patients With Brain Metastases From Breast Cancer
Status: TERMINATED
Study type: INTERVENTIONAL
Conditions: Estrogen Receptor-negative Breast Cancer|Extensive Stage Small Cell Lung Cancer|HER2-negative Breast Cancer|HER2-positive Breast Cancer|Male Breast Cancer|Recurrent Breast Cancer|Recurrent Melanoma|Recurrent Non-small Cell Lung Cancer|Recurrent Small Cell Lung Cancer|Stage IV Breast Cancer|Stage IV Melanoma|Stage IV Non-small Cell Lung Cancer|Tumors Metastatic to Brain|Unspecified Adult Solid Tumor, Protocol Specific
Interventions: DRUG: Gamma-secretase/Notch signalling pathway inhibitor RO4929097|RADIATION: Whole-brain radiation therapy (WBRT)|RADIATION: Stereotactic radiosurgery (SRS)|PROCEDURE: Cognitive assessment|OTHER: Laboratory biomarker analysis
Sponsor: National Cancer Institute (NCI)