Vaccine Therapy and Pembrolizumab in Treating Patients With Solid Tumors That Have Failed Prior Therapy
Status: ACTIVE_NOT_RECRUITING
Study type: INTERVENTIONAL
Conditions: Adult Solid Neoplasm|Bladder Carcinoma|Colon Carcinoma|Estrogen Receptor Negative|Head and Neck Squamous Cell Carcinoma|Hepatocellular Carcinoma|HER2/Neu Negative|Melanoma|Non-Small Cell Lung Carcinoma|Pancreatic Carcinoma|Progesterone Receptor Negative|Rectal Carcinoma|Renal Cell Carcinoma|Soft Tissue Sarcoma|Triple-Negative Breast Carcinoma|TP53 Gene Mutation|Unresectable Solid Neoplasm
Interventions: OTHER: Laboratory Biomarker Analysis|BIOLOGICAL: Modified Vaccinia Virus Ankara Vaccine Expressing p53|BIOLOGICAL: Pembrolizumab
Sponsor: City of Hope Medical Center
Collaborators: National Cancer Institute (NCI)