Neratinib and Paclitaxel With or Without Pertuzumab and Trastuzumab Before Combination Chemotherapy in Treating Patients With Metastatic or Locally Advanced Breast Cancer
Status: ACTIVE_NOT_RECRUITING
Study type: INTERVENTIONAL
Conditions: Breast Inflammatory Carcinoma|Locally Advanced Breast Carcinoma|Metastatic Breast Carcinoma|Stage III Breast Cancer AJCC v7|Stage IIIA Breast Cancer AJCC v7|Stage IIIB Breast Cancer AJCC v7|Stage IIIC Breast Cancer AJCC v7|Stage IV Breast Cancer AJCC v6 and v7
Interventions: DRUG: Cyclophosphamide|DRUG: Doxorubicin|OTHER: Laboratory Biomarker Analysis|DRUG: Neratinib|DRUG: Paclitaxel|BIOLOGICAL: Pertuzumab|BIOLOGICAL: Trastuzumab
Sponsor: M.D. Anderson Cancer Center
Collaborators: National Cancer Institute (NCI)